diff --git a/.idea/gradle.xml b/.idea/gradle.xml
index 32397a7e..e1397141 100644
--- a/.idea/gradle.xml
+++ b/.idea/gradle.xml
@@ -13,6 +13,7 @@
             <option value="$PROJECT_DIR$/modules/products/gradle" />
             <option value="$PROJECT_DIR$/modules/products/idea" />
             <option value="$PROJECT_DIR$/modules/products/nodejs" />
+            <option value="$PROJECT_DIR$/modules/products/python" />
             <option value="$PROJECT_DIR$/modules/products/rider" />
             <option value="$PROJECT_DIR$/modules/products/toml" />
           </set>
diff --git a/build.gradle.kts b/build.gradle.kts
index 0e2de323..80556817 100644
--- a/build.gradle.kts
+++ b/build.gradle.kts
@@ -34,6 +34,7 @@ dependencies {
         pluginModule(implementation(project(":mise-products-gradle")))
         pluginModule(implementation(project(":mise-products-idea")))
         pluginModule(implementation(project(":mise-products-nodejs")))
+        pluginModule(implementation(project(":mise-products-pycharm")))
         pluginModule(implementation(project(":mise-products-rider")))
         pluginModule(implementation(project(":mise-products-toml")))
 
diff --git a/modules/products/pycharm/build.gradle.kts b/modules/products/pycharm/build.gradle.kts
new file mode 100644
index 00000000..afbf84ef
--- /dev/null
+++ b/modules/products/pycharm/build.gradle.kts
@@ -0,0 +1,21 @@
+import org.jetbrains.intellij.platform.gradle.IntelliJPlatformType
+
+fun properties(key: String) = project.findProperty(key).toString()
+
+plugins {
+    id("org.jetbrains.intellij.platform.module")
+    alias(libs.plugins.kotlin) // Kotlin support
+}
+
+dependencies {
+    implementation(project(":mise-core"))
+
+    // Configure Gradle IntelliJ Plugin - read more: https://github.com/JetBrains/gradle-intellij-plugin
+    intellijPlatform {
+        create(IntelliJPlatformType.PyCharmCommunity, properties("platformVersion"))
+
+        bundledPlugins("PythonCore")
+
+        jetbrainsRuntime()
+    }
+}
diff --git a/modules/products/pycharm/src/main/kotlin/com/github/l34130/mise/python/run/PythonCommandLineTargetEnvironmentProvider.kt b/modules/products/pycharm/src/main/kotlin/com/github/l34130/mise/python/run/PythonCommandLineTargetEnvironmentProvider.kt
new file mode 100644
index 00000000..5e820620
--- /dev/null
+++ b/modules/products/pycharm/src/main/kotlin/com/github/l34130/mise/python/run/PythonCommandLineTargetEnvironmentProvider.kt
@@ -0,0 +1,56 @@
+package com.github.l34130.mise.python.run
+
+import com.github.l34130.mise.core.command.MiseCommandLineHelper
+import com.github.l34130.mise.core.command.MiseCommandLineNotFoundException
+import com.github.l34130.mise.core.notification.MiseNotificationServiceUtils
+import com.github.l34130.mise.core.run.MiseRunConfigurationSettingsEditor
+import com.github.l34130.mise.core.setting.MiseSettings
+import com.intellij.openapi.components.service
+import com.intellij.openapi.project.Project
+import com.jetbrains.python.run.AbstractPythonRunConfiguration
+import com.jetbrains.python.run.PythonExecution
+import com.jetbrains.python.run.PythonRunParams
+import com.jetbrains.python.run.target.HelpersAwareTargetEnvironmentRequest
+import com.jetbrains.python.run.target.PythonCommandLineTargetEnvironmentProvider
+
+@Suppress("UnstableApiUsage")
+class PythonCommandLineTargetEnvironmentProvider : PythonCommandLineTargetEnvironmentProvider {
+    override fun extendTargetEnvironment(
+        project: Project,
+        helpersAwareTargetRequest: HelpersAwareTargetEnvironmentRequest,
+        pythonExecution: PythonExecution,
+        runParams: PythonRunParams,
+    ) {
+        if (runParams is AbstractPythonRunConfiguration<*>) {
+            val projectState = project.service<MiseSettings>().state
+            val runConfigState = MiseRunConfigurationSettingsEditor.getMiseRunConfigurationState(runParams)
+
+            val (workDir, configEnvironment) =
+                when {
+                    projectState.useMiseDirEnv -> project.basePath to projectState.miseConfigEnvironment
+                    runConfigState?.useMiseDirEnv == true -> {
+                        val pythonWorkDir = runParams.workingDirectory ?: runParams.projectPathOnTarget
+                        (pythonWorkDir ?: runParams.project.basePath) to runConfigState.miseConfigEnvironment
+                    }
+                    else -> null to null
+                }
+
+            val envVars =
+                MiseCommandLineHelper
+                    .getEnvVars(workDir, configEnvironment)
+                    .fold(
+                        onSuccess = { envVars -> envVars },
+                        onFailure = {
+                            if (it !is MiseCommandLineNotFoundException) {
+                                MiseNotificationServiceUtils.notifyException("Failed to load environment variables", it)
+                            }
+                            emptyMap()
+                        },
+                    )
+
+            envVars.forEach { (key, value) ->
+                pythonExecution.addEnvironmentVariable(key, value)
+            }
+        }
+    }
+}
diff --git a/modules/products/pycharm/src/main/kotlin/com/github/l34130/mise/python/run/PythonRunConfigurationExtension.kt b/modules/products/pycharm/src/main/kotlin/com/github/l34130/mise/python/run/PythonRunConfigurationExtension.kt
new file mode 100644
index 00000000..82ba1735
--- /dev/null
+++ b/modules/products/pycharm/src/main/kotlin/com/github/l34130/mise/python/run/PythonRunConfigurationExtension.kt
@@ -0,0 +1,78 @@
+package com.github.l34130.mise.python.run
+
+import com.github.l34130.mise.core.command.MiseCommandLineHelper
+import com.github.l34130.mise.core.command.MiseCommandLineNotFoundException
+import com.github.l34130.mise.core.notification.MiseNotificationServiceUtils
+import com.github.l34130.mise.core.run.MiseRunConfigurationSettingsEditor
+import com.github.l34130.mise.core.setting.MiseSettings
+import com.intellij.execution.configurations.GeneralCommandLine
+import com.intellij.execution.configurations.RunnerSettings
+import com.intellij.openapi.components.service
+import com.intellij.openapi.options.SettingsEditor
+import com.jetbrains.python.run.AbstractPythonRunConfiguration
+import com.jetbrains.python.run.PythonRunConfigurationExtension
+import org.jdom.Element
+
+class PythonRunConfigurationExtension : PythonRunConfigurationExtension() {
+    override fun isApplicableFor(runConfiguration: AbstractPythonRunConfiguration<*>): Boolean = true
+
+    override fun isEnabledFor(
+        runConfiguration: AbstractPythonRunConfiguration<*>,
+        runnerSettings: RunnerSettings?,
+    ): Boolean = true
+
+    override fun writeExternal(
+        runConfiguration: AbstractPythonRunConfiguration<*>,
+        element: Element,
+    ) {
+        MiseRunConfigurationSettingsEditor.writeExternal(runConfiguration, element)
+    }
+
+    override fun readExternal(
+        runConfiguration: AbstractPythonRunConfiguration<*>,
+        element: Element,
+    ) {
+        MiseRunConfigurationSettingsEditor.readExternal(runConfiguration, element)
+    }
+
+    override fun getEditorTitle(): String = MiseRunConfigurationSettingsEditor.EDITOR_TITLE
+
+    override fun <P : AbstractPythonRunConfiguration<*>> createEditor(configuration: P): SettingsEditor<P> =
+        MiseRunConfigurationSettingsEditor(configuration.project)
+
+    override fun patchCommandLine(
+        runConfiguration: AbstractPythonRunConfiguration<*>,
+        runnerSettings: RunnerSettings?,
+        cmdLine: GeneralCommandLine,
+        runnerId: String,
+    ) {
+        val project = runConfiguration.project
+        val projectState = project.service<MiseSettings>().state
+        val runConfigState = MiseRunConfigurationSettingsEditor.getMiseRunConfigurationState(runConfiguration)
+
+        val (workDir, configEnvironment) =
+            when {
+                projectState.useMiseDirEnv -> project.basePath to projectState.miseConfigEnvironment
+                runConfigState?.useMiseDirEnv == true -> {
+                    val pythonWorkDir = runConfiguration.workingDirectory ?: runConfiguration.projectPathOnTarget
+                    (pythonWorkDir ?: runConfiguration.project.basePath) to runConfigState.miseConfigEnvironment
+                }
+                else -> null to null
+            }
+
+        val envVars =
+            MiseCommandLineHelper
+                .getEnvVars(workDir, configEnvironment)
+                .fold(
+                    onSuccess = { envVars -> envVars },
+                    onFailure = {
+                        if (it !is MiseCommandLineNotFoundException) {
+                            MiseNotificationServiceUtils.notifyException("Failed to load environment variables", it)
+                        }
+                        emptyMap()
+                    },
+                )
+
+        cmdLine.withEnvironment(envVars)
+    }
+}
diff --git a/settings.gradle.kts b/settings.gradle.kts
index 9cb3f6dc..9d6af07c 100644
--- a/settings.gradle.kts
+++ b/settings.gradle.kts
@@ -22,6 +22,7 @@ include(
     "modules/products/gradle",
     "modules/products/idea",
     "modules/products/nodejs",
+    "modules/products/pycharm",
     "modules/products/rider",
     "modules/products/toml",
 )
diff --git a/src/main/resources/META-INF/mise-pycharm.xml b/src/main/resources/META-INF/mise-pycharm.xml
new file mode 100644
index 00000000..728265dc
--- /dev/null
+++ b/src/main/resources/META-INF/mise-pycharm.xml
@@ -0,0 +1,7 @@
+<idea-plugin require-restart="false">
+    <extensions defaultExtensionNs="Pythonid">
+        <runConfigurationExtension implementation="com.github.l34130.mise.python.run.PythonRunConfigurationExtension"
+                                   id="misePython"/>
+        <pythonCommandLineTargetEnvironmentProvider implementation="com.github.l34130.mise.python.run.PythonCommandLineTargetEnvironmentProvider"/>
+    </extensions>
+</idea-plugin>
diff --git a/src/main/resources/META-INF/plugin.xml b/src/main/resources/META-INF/plugin.xml
index 15d810c9..f69737e7 100644
--- a/src/main/resources/META-INF/plugin.xml
+++ b/src/main/resources/META-INF/plugin.xml
@@ -37,6 +37,7 @@
     <depends optional="true" config-file="mise-gradle.xml">com.intellij.gradle</depends>
     <depends optional="true" config-file="mise-idea.xml">com.intellij.java</depends>
     <depends optional="true" config-file="mise-javascript.xml">JavaScript</depends>
+    <depends optional="true" config-file="mise-pycharm.xml">com.intellij.modules.python</depends>
     <depends optional="true" config-file="mise-rider.xml">com.intellij.modules.rider</depends>
     <depends optional="true" config-file="mise-toml.xml">org.toml.lang</depends>
 </idea-plugin>