diff --git a/python/instrumentation/openinference-instrumentation-portkey/src/openinference/instrumentation/portkey/__init__.py b/python/instrumentation/openinference-instrumentation-portkey/src/openinference/instrumentation/portkey/__init__.py
index 521e41dc7a..981c4defc0 100644
--- a/python/instrumentation/openinference-instrumentation-portkey/src/openinference/instrumentation/portkey/__init__.py
+++ b/python/instrumentation/openinference-instrumentation-portkey/src/openinference/instrumentation/portkey/__init__.py
@@ -4,11 +4,17 @@
 
 from opentelemetry import trace as trace_api
 from opentelemetry.instrumentation.instrumentor import BaseInstrumentor  # type: ignore
-from portkey_ai.api_resources.apis.chat_complete import Completions
+from portkey_ai.api_resources.apis.chat_complete import (
+    AsyncCompletions,
+    Completions,
+)
 from wrapt import wrap_function_wrapper
 
 from openinference.instrumentation import OITracer, TraceConfig
-from openinference.instrumentation.portkey._wrappers import _CompletionsWrapper
+from openinference.instrumentation.portkey._wrappers import (
+    _AsyncCompletionsWrapper,
+    _CompletionsWrapper,
+)
 from openinference.instrumentation.portkey.version import __version__
 
 logger = logging.getLogger(__name__)
@@ -20,7 +26,7 @@
 class PortkeyInstrumentor(BaseInstrumentor):  # type: ignore[misc]
     """An instrumentor for the Portkey AI framework."""
 
-    __slots__ = ("_original_completions_create", "_tracer")
+    __slots__ = ("_original_completions_create", "_original_async_completions_create", "_tracer")
 
     def instrumentation_dependencies(self) -> Collection[str]:
         return _instruments
@@ -49,7 +55,22 @@ def _instrument(self, **kwargs: Any) -> None:
             wrapper=_CompletionsWrapper(tracer=self._tracer),
         )
 
+        self._original_async_completions_create = AsyncCompletions.create
+        wrap_function_wrapper(
+            module="portkey_ai.api_resources.apis.chat_complete",
+            name="AsyncCompletions.create",
+            wrapper=_AsyncCompletionsWrapper(tracer=self._tracer),
+        )
+        wrap_function_wrapper(
+            module="portkey_ai.api_resources.apis.generation",
+            name="AsyncCompletions.create",
+            wrapper=_AsyncCompletionsWrapper(tracer=self._tracer),
+        )
+
     def _uninstrument(self, **kwargs: Any) -> None:
         portkey_module = import_module("portkey_ai.api_resources.apis.chat_complete")
         if self._original_completions_create is not None:
             portkey_module.Completions.create = self._original_completions_create
+
+        if self._original_async_completions_create is not None:
+            portkey_module.AsyncCompletions.create = self._original_async_completions_create
diff --git a/python/instrumentation/openinference-instrumentation-portkey/src/openinference/instrumentation/portkey/_wrappers.py b/python/instrumentation/openinference-instrumentation-portkey/src/openinference/instrumentation/portkey/_wrappers.py
index 4394d562fe..9d5d7f5386 100644
--- a/python/instrumentation/openinference-instrumentation-portkey/src/openinference/instrumentation/portkey/_wrappers.py
+++ b/python/instrumentation/openinference-instrumentation-portkey/src/openinference/instrumentation/portkey/_wrappers.py
@@ -143,5 +143,62 @@ def __call__(
             except Exception:
                 logger.exception(f"Failed to finalize response of type {type(response)}")
                 span.finish_tracing()
-            finally:
-                return response
+            return response
+
+
+class _AsyncCompletionsWrapper(_WithTracer):
+    def __init__(self, *args: Any, **kwargs: Any) -> None:
+        super().__init__(*args, **kwargs)
+        self._request_extractor = _RequestAttributesExtractor()
+        self._response_extractor = _ResponseAttributesExtractor()
+
+    async def __call__(
+        self,
+        wrapped: Callable[..., Any],
+        instance: Any,
+        args: Tuple[Any, ...],
+        kwargs: Mapping[str, Any],
+    ) -> Any:
+        if context_api.get_value(context_api._SUPPRESS_INSTRUMENTATION_KEY):
+            return await wrapped(*args, **kwargs)
+
+        # Prepare invocation parameters by merging args and kwargs
+        invocation_parameters = {**kwargs}
+        for arg in args:
+            if isinstance(arg, dict):
+                invocation_parameters.update(arg)
+
+        request_parameters = _parse_args(signature(wrapped), *args, **kwargs)
+        span_name = "AsyncCompletions"
+        with self._start_as_current_span(
+            span_name=span_name,
+            attributes=self._request_extractor.get_attributes_from_request(request_parameters),
+            context_attributes=get_attributes_from_context(),
+            extra_attributes=self._request_extractor.get_extra_attributes_from_request(
+                request_parameters
+            ),
+        ) as span:
+            try:
+                response = await wrapped(*args, **kwargs)
+            except Exception as exception:
+                span.record_exception(exception)
+                status = trace_api.Status(
+                    status_code=trace_api.StatusCode.ERROR,
+                    description=f"{type(exception).__name__}: {exception}",
+                )
+                span.finish_tracing(status=status)
+                raise
+            try:
+                _finish_tracing(
+                    with_span=span,
+                    attributes=self._response_extractor.get_attributes(response),
+                    extra_attributes=self._response_extractor.get_extra_attributes(
+                        response=response,
+                        request_parameters=request_parameters,
+                    ),
+                    status=trace_api.Status(status_code=trace_api.StatusCode.OK),
+                )
+            except Exception:
+                logger.exception(f"Failed to finalize response of type {type(response)}")
+                span.finish_tracing()
+            return response
diff --git a/python/instrumentation/openinference-instrumentation-portkey/tests/cassettes/test_async_chat_completion.yaml b/python/instrumentation/openinference-instrumentation-portkey/tests/cassettes/test_async_chat_completion.yaml
new file mode 100644
index 0000000000..e2cf629125
--- /dev/null
+++ b/python/instrumentation/openinference-instrumentation-portkey/tests/cassettes/test_async_chat_completion.yaml
@@ -0,0 +1,66 @@
+interactions:
+- request:
+    body: '{"messages":[{"role":"user","content":"What''s the weather like?"}],"model":"gpt-4o-mini"}'
+    headers:
+      accept:
+      - application/json
+      accept-encoding:
+      - gzip, deflate
+      authorization:
+      - Bearer OPENAI_API_KEY
+      connection:
+      - keep-alive
+      content-length:
+      - '89'
+      content-type:
+      - application/json
+      host:
+      - api.portkey.ai
+      user-agent:
+      - AsyncOpenAI/Python 2.2.0
+      x-stainless-arch:
+      - arm64
+      x-stainless-async:
+      - async:asyncio
+      x-stainless-lang:
+      - python
+      x-stainless-os:
+      - MacOS
+      x-stainless-package-version:
+      - 2.2.0
+      x-stainless-raw-response:
+      - 'true'
+      x-stainless-read-timeout:
+      - '600'
+      x-stainless-retry-count:
+      - '0'
+      x-stainless-runtime:
+      - CPython
+      x-stainless-runtime-version:
+      - 3.10.0
+    method: POST
+    uri: https://api.portkey.ai/v1/chat/completions
+  response:
+    body:
+      string: '{"id":"chatcmpl-AsyncTest123456789","object":"chat.completion","created":1743882894,"model":"gpt-4o-mini-2024-07-18","choices":[{"index":0,"message":{"role":"assistant","content":"I don''t have real-time data access to provide current weather updates. However, you can check a weather website or app for the latest information in your area. If you tell me your location, I can suggest typical weather patterns for this time of year!","refusal":null,"annotations":[]},"logprobs":null,"finish_reason":"stop"}],"usage":{"prompt_tokens":12,"completion_tokens":51,"total_tokens":63,"prompt_tokens_details":{"cached_tokens":0,"audio_tokens":0},"completion_tokens_details":{"reasoning_tokens":0,"audio_tokens":0,"accepted_prediction_tokens":0,"rejected_prediction_tokens":0}},"service_tier":"default","system_fingerprint":"fp_b376dfbbd5"}'
+    headers:
+      CF-RAY:
+      - 99984826acb4cb94-LAX
+      Connection:
+      - keep-alive
+      Content-Length:
+      - '694'
+      Content-Type:
+      - application/json;charset=UTF-8
+      Date:
+      - Wed, 05 Nov 2025 00:37:18 GMT
+      Server:
+      - cloudflare
+      Vary:
+      - accept-encoding
+      alt-svc:
+      - h3=":443"; ma=86400
+    status:
+      code: 200
+      message: OK
+version: 1
\ No newline at end of file
diff --git a/python/instrumentation/openinference-instrumentation-portkey/tests/cassettes/test_async_prompt_template.yaml b/python/instrumentation/openinference-instrumentation-portkey/tests/cassettes/test_async_prompt_template.yaml
new file mode 100644
index 0000000000..8779a7804c
--- /dev/null
+++ b/python/instrumentation/openinference-instrumentation-portkey/tests/cassettes/test_async_prompt_template.yaml
@@ -0,0 +1,74 @@
+interactions:
+- request:
+    body: '{"variables":{"location":"New York City"},"stream":false}'
+    headers:
+      accept:
+      - application/json
+      accept-encoding:
+      - gzip, deflate
+      connection:
+      - keep-alive
+      content-length:
+      - '57'
+      content-type:
+      - application/json
+      host:
+      - api.portkey.ai
+      user-agent:
+      - python-httpx/0.28.1
+    method: POST
+    uri: https://api.portkey.ai/v1/prompts/pp-weather-pr-b74c4f/completions
+  response:
+    body:
+      string: '{"id":"chatcmpl-AsyncPromptTest789","object":"chat.completion","created":1743882894,"model":"gpt-4.1-2025-04-14","choices":[{"finish_reason":"stop","index":0,"message":{"content":"Based on the current weather data, New York City is experiencing partly cloudy skies with a temperature of around 72°F (22°C). There''s a light breeze from the northwest at about 8 mph. Humidity levels are moderate at around 55%. It''s a pleasant spring day overall with no precipitation expected in the immediate forecast.","role":"assistant","refusal":null,"annotations":[]},"logprobs":null}],"usage":{"completion_tokens":66,"prompt_tokens":35,"total_tokens":101,"prompt_tokens_details":{"cached_tokens":0},"completion_tokens_details":{"reasoning_tokens":0}},"service_tier":"default","system_fingerprint":"fp_test123"}'
+    headers:
+      CF-Cache-Status:
+      - DYNAMIC
+      CF-Ray:
+      - 943debc01e8b1492-EWR
+      Connection:
+      - keep-alive
+      Content-Type:
+      - application/json
+      Date:
+      - Thu, 22 May 2025 17:09:26 GMT
+      Server:
+      - cloudflare
+      Strict-Transport-Security:
+      - max-age=31536000; includeSubDomains; preload
+      Transfer-Encoding:
+      - chunked
+      Vary:
+      - Accept-Encoding
+      X-Content-Type-Options:
+      - nosniff
+      access-control-expose-headers:
+      - X-Request-ID
+      alt-svc:
+      - h3=":443"; ma=86400
+      openai-organization:
+      - arize-ai-ewa7w1
+      openai-processing-ms:
+      - '3213'
+      openai-version:
+      - '2020-10-01'
+      x-envoy-upstream-service-time:
+      - '3221'
+      x-ratelimit-limit-requests:
+      - '10000'
+      x-ratelimit-limit-tokens:
+      - '30000000'
+      x-ratelimit-remaining-requests:
+      - '9999'
+      x-ratelimit-remaining-tokens:
+      - '29999965'
+      x-ratelimit-reset-requests:
+      - 6ms
+      x-ratelimit-reset-tokens:
+      - 0s
+      x-request-id:
+      - req_24c239d275655c5f601e70346c6cd0f6
+    status:
+      code: 200
+      message: OK
+version: 1
\ No newline at end of file
diff --git a/python/instrumentation/openinference-instrumentation-portkey/tests/test_instrumentor.py b/python/instrumentation/openinference-instrumentation-portkey/tests/test_instrumentor.py
index a014fe7611..7a0ead8eeb 100644
--- a/python/instrumentation/openinference-instrumentation-portkey/tests/test_instrumentor.py
+++ b/python/instrumentation/openinference-instrumentation-portkey/tests/test_instrumentor.py
@@ -117,3 +117,118 @@ def test_prompt_template(
 
     for key, expected_value in expected_attributes.items():
         assert attributes.get(key) == expected_value
+
+
+@pytest.mark.asyncio
+@pytest.mark.vcr(
+    before_record_request=lambda request: setattr(  # type: ignore[func-returns-value]
+        request,
+        "headers",
+        {k: v for k, v in request.headers.items() if not k.lower().startswith("x-portkey")},
+    )
+    or request,
+    before_record_response=lambda response: {
+        **response,
+        "headers": {
+            k: v for k, v in response["headers"].items() if not k.lower().startswith("x-portkey")
+        },
+    },
+)
+async def test_async_chat_completion(
+    in_memory_span_exporter: InMemorySpanExporter,
+    tracer_provider: trace_api.TracerProvider,
+    setup_portkey_instrumentation: None,
+) -> None:
+    portkey = import_module("portkey_ai")
+    client = portkey.AsyncPortkey(
+        api_key="REDACTED",
+        virtual_key="REDACTED",
+    )
+    resp = await client.chat.completions.create(
+        messages=[{"role": "user", "content": "What's the weather like?"}], model="gpt-4o-mini"
+    )
+    spans = in_memory_span_exporter.get_finished_spans()
+    assert len(spans) == 1
+    span = spans[0]
+    assert span.name == "AsyncCompletions"
+    attributes = dict(span.attributes or {})
+
+    expected_attributes = {
+        f"{SpanAttributes.LLM_INPUT_MESSAGES}.0.{MessageAttributes.MESSAGE_ROLE}": "user",
+        f"{SpanAttributes.LLM_INPUT_MESSAGES}.0."
+        f"{MessageAttributes.MESSAGE_CONTENT}": "What's the weather like?",
+        SpanAttributes.OUTPUT_MIME_TYPE: "application/json",
+        SpanAttributes.INPUT_MIME_TYPE: "application/json",
+        SpanAttributes.LLM_MODEL_NAME: "gpt-4o-mini-2024-07-18",
+        SpanAttributes.LLM_TOKEN_COUNT_TOTAL: resp.usage.total_tokens,
+        SpanAttributes.LLM_TOKEN_COUNT_PROMPT: resp.usage.prompt_tokens,
+        SpanAttributes.LLM_TOKEN_COUNT_COMPLETION: resp.usage.completion_tokens,
+        f"{SpanAttributes.LLM_OUTPUT_MESSAGES}.0.{MessageAttributes.MESSAGE_ROLE}": resp.choices[
+            0
+        ].message.role,
+        f"{SpanAttributes.LLM_OUTPUT_MESSAGES}.0.{MessageAttributes.MESSAGE_CONTENT}": resp.choices[
+            0
+        ].message.content,
+        SpanAttributes.OPENINFERENCE_SPAN_KIND: "LLM",
+    }
+
+    for key, expected_value in expected_attributes.items():
+        assert attributes.get(key) == expected_value
+
+
+@pytest.mark.asyncio
+@pytest.mark.vcr(
+    before_record_request=lambda request: setattr(  # type: ignore[func-returns-value]
+        request,
+        "headers",
+        {k: v for k, v in request.headers.items() if not k.lower().startswith("x-portkey")},
+    )
+    or request,
+    before_record_response=lambda response: {
+        **response,
+        "headers": {
+            k: v for k, v in response["headers"].items() if not k.lower().startswith("x-portkey")
+        },
+    },
+)
+async def test_async_prompt_template(
+    in_memory_span_exporter: InMemorySpanExporter,
+    tracer_provider: trace_api.TracerProvider,
+    setup_portkey_instrumentation: None,
+) -> None:
+    prompt_id = "pp-weather-pr-b74c4f"
+    portkey = import_module("portkey_ai")
+    variables = {"location": "New York City"}
+    client = portkey.AsyncPortkey(
+        api_key="REDACTED",
+        virtual_key="REDACTED",
+    )
+    resp = await client.prompts.completions.create(
+        prompt_id=prompt_id,
+        variables=variables,
+    )
+
+    spans = in_memory_span_exporter.get_finished_spans()
+    assert len(spans) == 1
+    span = spans[0]
+    assert span.name == "AsyncCompletions"
+    attributes = dict(span.attributes or {})
+
+    expected_attributes = {
+        SpanAttributes.OUTPUT_MIME_TYPE: "application/json",
+        SpanAttributes.INPUT_MIME_TYPE: "application/json",
+        SpanAttributes.LLM_MODEL_NAME: "gpt-4.1-2025-04-14",
+        SpanAttributes.LLM_TOKEN_COUNT_TOTAL: resp.usage.total_tokens,
+        SpanAttributes.LLM_TOKEN_COUNT_PROMPT: resp.usage.prompt_tokens,
+        SpanAttributes.LLM_TOKEN_COUNT_COMPLETION: resp.usage.completion_tokens,
+        SpanAttributes.PROMPT_ID: prompt_id,
+        SpanAttributes.LLM_PROMPT_TEMPLATE_VARIABLES: json.dumps(variables),
+        f"{SpanAttributes.LLM_OUTPUT_MESSAGES}.0.{MessageAttributes.MESSAGE_ROLE}": "assistant",
+        f"{SpanAttributes.LLM_OUTPUT_MESSAGES}.0.{MessageAttributes.MESSAGE_CONTENT}": resp.choices[
+            0
+        ].message.content,
+        SpanAttributes.OPENINFERENCE_SPAN_KIND: "LLM",
+    }
+
+    for key, expected_value in expected_attributes.items():
+        assert attributes.get(key) == expected_value