diff --git a/tests/common/plugins/conditional_mark/tests_mark_conditions.yaml b/tests/common/plugins/conditional_mark/tests_mark_conditions.yaml
index 985f7fa0e..bc68faf1f 100644
--- a/tests/common/plugins/conditional_mark/tests_mark_conditions.yaml
+++ b/tests/common/plugins/conditional_mark/tests_mark_conditions.yaml
@@ -3628,9 +3628,7 @@ route/test_default_route.py:
 route/test_default_route.py::test_default_route_set_src:
   xfail:
     reason: "xfail for IPv6-only topologies, need add support for IPv6-only"
-    conditions_logical_operator: or
     conditions:
-      - "https://github.com/sonic-net/sonic-mgmt/issues/19925 and '-v6-' in topo_name"
       - "https://github.com/sonic-net/sonic-buildimage/issues/24537 and 't0-isolated-d256u256s2' in topo_name"
 
 route/test_default_route.py::test_default_route_with_bgp_flap:
diff --git a/tests/route/test_default_route.py b/tests/route/test_default_route.py
index 2e4d00c4d..50c23ebc7 100644
--- a/tests/route/test_default_route.py
+++ b/tests/route/test_default_route.py
@@ -10,6 +10,7 @@
 from tests.common.utilities import wait_until
 from tests.common.utilities import find_duthost_on_role
 from tests.common.utilities import get_upstream_neigh_type, get_all_upstream_neigh_type
+from tests.common.utilities import is_ipv6_only_topology
 from tests.common.helpers.syslog_helpers import is_mgmt_vrf_enabled
 
 
@@ -153,6 +154,9 @@ def test_default_route_set_src(duthosts, tbinfo):
     config_facts = asichost.config_facts(
         host=duthost.hostname, source="running")['ansible_facts']
 
+    ipv6_only = is_ipv6_only_topology(tbinfo)
+    logger.info("IPv6-only topology: {}".format(ipv6_only))
+
     lo_ipv4 = None
     lo_ipv6 = None
     los = config_facts.get("LOOPBACK_INTERFACE", {})
@@ -166,14 +170,16 @@ def test_default_route_set_src(duthosts, tbinfo):
                 elif ip.version == 6:
                     lo_ipv6 = ip
 
-    pytest_assert(lo_ipv4, "cannot find ipv4 Loopback0 address")
+    if not ipv6_only:
+        pytest_assert(lo_ipv4, "cannot find ipv4 Loopback0 address")
     pytest_assert(lo_ipv6, "cannot find ipv6 Loopback0 address")
 
-    rtinfo = asichost.get_ip_route_info(ipaddress.ip_network("0.0.0.0/0"))
-    pytest_assert(rtinfo['set_src'],
-                  "default route do not have set src. {}".format(rtinfo))
-    pytest_assert(rtinfo['set_src'] == lo_ipv4.ip,
-                  "default route set src to wrong IP {} != {}".format(rtinfo['set_src'], lo_ipv4.ip))
+    if not ipv6_only:
+        rtinfo = asichost.get_ip_route_info(ipaddress.ip_network("0.0.0.0/0"))
+        pytest_assert(rtinfo['set_src'],
+                      "default route do not have set src. {}".format(rtinfo))
+        pytest_assert(rtinfo['set_src'] == lo_ipv4.ip,
+                      "default route set src to wrong IP {} != {}".format(rtinfo['set_src'], lo_ipv4.ip))
 
     rtinfo = asichost.get_ip_route_info(ipaddress.ip_network("::/0"))
     pytest_assert(
@@ -263,7 +269,9 @@ def test_default_route_with_bgp_flap(duthosts, tbinfo):
         uplink_ns = get_uplink_ns(
             tbinfo, bgp_name_to_ns_mapping, config_facts['DEVICE_NEIGHBOR_METADATA'])
 
-    af_list = ['ipv4', 'ipv6']
+    ipv6_only = is_ipv6_only_topology(tbinfo)
+    af_list = ['ipv6'] if ipv6_only else ['ipv4', 'ipv6']
+    logger.info("IPv6-only topology: {}, testing address families: {}".format(ipv6_only, af_list))
 
     try:
         # verify the default route is correct in the app db