diff --git a/src/bria_client/toolkit/image.py b/src/bria_client/toolkit/image.py
index 0a2add0..21a5fcd 100644
--- a/src/bria_client/toolkit/image.py
+++ b/src/bria_client/toolkit/image.py
@@ -62,6 +62,8 @@ def _process_image(self, image: ImageSource) -> Base64String | str:
         if isinstance(image, str):
             if image.startswith("http"):
                 return image
+            if image.startswith("data:") and ";base64," in image:
+                return image.split(",", 1)[-1]
             if Image.is_base64(image):
                 return image
             # infer it is a local path
diff --git a/tests/unit/toolkit/test_image.py b/tests/unit/toolkit/test_image.py
index 01da2fc..156ba54 100644
--- a/tests/unit/toolkit/test_image.py
+++ b/tests/unit/toolkit/test_image.py
@@ -15,6 +15,15 @@ def test_image_on_init_should_work_for_all_image_source_types(self, image_source
         # Assert
         assert image.as_bria_api_input is not None
 
+    @pytest.mark.parametrize("prefix", ["data:image/png;base64,", "data:image/jpeg;base64,"])
+    def test_image_on_init_with_base64_data_uri_should_process_successfully(self, base64_image, prefix):
+        # Arrange
+        base64_with_header = f"{prefix}{base64_image}"
+        # Act
+        image = Image(base64_with_header)
+        # Assert
+        assert Image.is_base64(image.as_bria_api_input)
+
 
 @pytest.mark.unit
 class TestImageSource: