diff --git a/etor/src/main/java/gov/hhs/cdc/trustedintermediary/etor/ruleengine/transformation/custom/CopyOrcOrderProviderToObrOrderProvider.java b/etor/src/main/java/gov/hhs/cdc/trustedintermediary/etor/ruleengine/transformation/custom/CopyOrcOrderProviderToObrOrderProvider.java new file mode 100644 index 000000000..cb128efb7 --- /dev/null +++ b/etor/src/main/java/gov/hhs/cdc/trustedintermediary/etor/ruleengine/transformation/custom/CopyOrcOrderProviderToObrOrderProvider.java @@ -0,0 +1,43 @@ +package gov.hhs.cdc.trustedintermediary.etor.ruleengine.transformation.custom; + +import gov.hhs.cdc.trustedintermediary.etor.ruleengine.FhirResource; +import gov.hhs.cdc.trustedintermediary.etor.ruleengine.transformation.CustomFhirTransformation; +import gov.hhs.cdc.trustedintermediary.external.hapi.HapiHelper; +import java.util.Map; +import org.hl7.fhir.r4.model.Bundle; +import org.hl7.fhir.r4.model.DiagnosticReport; +import org.hl7.fhir.r4.model.Extension; +import org.hl7.fhir.r4.model.ServiceRequest; + +/** Updates the order provider (OBR-16) from the order provider (ORC-12) */ +public class CopyOrcOrderProviderToObrOrderProvider implements CustomFhirTransformation { + + @Override + public void transform(FhirResource resource, Map args) { + Bundle bundle = (Bundle) resource.getUnderlyingResource(); + DiagnosticReport diagnosticReport = HapiHelper.getDiagnosticReport(bundle); + if (diagnosticReport == null) { + return; + } + ServiceRequest serviceRequest = HapiHelper.getServiceRequest(diagnosticReport); + if (serviceRequest == null) { + return; + } + var practitionerRole = HapiHelper.getPractitionerRole(serviceRequest); + if (practitionerRole == null) { + return; + } + + // Extract or create the OBR-16 extension from the ServiceRequest + Extension obrExtension = + HapiHelper.ensureExtensionExists(serviceRequest, HapiHelper.EXTENSION_OBR_URL); + + // Extract or create the OBR-16 data type extension + Extension obr16Extension = + HapiHelper.ensureSubExtensionExists( + obrExtension, HapiHelper.EXTENSION_OBR16_DATA_TYPE.toString()); + + // Set the ORC-12 Practitioner in the OBR-16 extension + HapiHelper.setOBR16WithPractitioner(obr16Extension, practitionerRole); + } +} diff --git a/etor/src/main/java/gov/hhs/cdc/trustedintermediary/plugin/path/Hl7FhirMappingPath.java b/etor/src/main/java/gov/hhs/cdc/trustedintermediary/plugin/path/Hl7FhirMappingPath.java index 6e59fd47f..36680b55b 100644 --- a/etor/src/main/java/gov/hhs/cdc/trustedintermediary/plugin/path/Hl7FhirMappingPath.java +++ b/etor/src/main/java/gov/hhs/cdc/trustedintermediary/plugin/path/Hl7FhirMappingPath.java @@ -17,6 +17,14 @@ public enum Hl7FhirMappingPath { """ Bundle.entry.resource.ofType(ServiceRequest).extension.where(url = 'https://reportstream.cdc.gov/fhir/StructureDefinition/obr-observation-request').extension.where(url = 'OBR.2').value """), + ORDERING_PROVIDER_ORC_12( + "ORC.12", + "Bundle.entry.resource.ofType(ServiceRequest).requester.resolve().practicioner.resolve().name"), + ORDERING_PROVIDER_OBR_16( + "OBR.16", + """ + Bundle.entry.resource.ofType(ServiceRequest).extension.where(url='https://reportstream.cdc.gov/fhir/StructureDefinition/obr-observation-request’).extension.where(url='OBR.16').resolve().name + """), SENDING_FACILITY_NAMESPACE( "", """ diff --git a/etor/src/main/resources/transformation_definitions.json b/etor/src/main/resources/transformation_definitions.json index 9bd59f526..70d51d4ec 100644 --- a/etor/src/main/resources/transformation_definitions.json +++ b/etor/src/main/resources/transformation_definitions.json @@ -186,6 +186,22 @@ } } ] + }, + { + "name": "ucsdOruCopyOrcOrderProviderToObrOrderProvider", + "description": "Copies the value from ORC12 and uses this value to replace the value in OBR16", + "message": "", + "conditions": [ + "Bundle.entry.resource.ofType(MessageHeader).destination.receiver.resolve().identifier.where(extension.value = 'HD.1').value in ('R797' | 'R508')", + "Bundle.entry.resource.ofType(MessageHeader).event.code = 'R01'", + "Bundle.entry.resource.ofType(ServiceRequest).code.coding.where(code = '54089-8').exists()" + ], + "rules": [ + { + "name": "CopyOrcOrderProviderToObrOrderProvider", + "args": {} + } + ] } ] } diff --git a/etor/src/test/groovy/gov/hhs/cdc/trustedintermediary/etor/ruleengine/transformation/custom/CopyOrcOrderProviderToObrOrderProviderTest.groovy b/etor/src/test/groovy/gov/hhs/cdc/trustedintermediary/etor/ruleengine/transformation/custom/CopyOrcOrderProviderToObrOrderProviderTest.groovy new file mode 100644 index 000000000..d4e7b4f4d --- /dev/null +++ b/etor/src/test/groovy/gov/hhs/cdc/trustedintermediary/etor/ruleengine/transformation/custom/CopyOrcOrderProviderToObrOrderProviderTest.groovy @@ -0,0 +1,252 @@ +package gov.hhs.cdc.trustedintermediary.etor.ruleengine.transformation.custom + +import gov.hhs.cdc.trustedintermediary.ExamplesHelper +import gov.hhs.cdc.trustedintermediary.context.TestApplicationContext +import gov.hhs.cdc.trustedintermediary.etor.ruleengine.FhirResource +import gov.hhs.cdc.trustedintermediary.external.hapi.HapiFhirResource +import gov.hhs.cdc.trustedintermediary.external.hapi.HapiHelper +import gov.hhs.cdc.trustedintermediary.wrappers.MetricMetadata +import org.hl7.fhir.r4.model.Bundle +import org.hl7.fhir.r4.model.DiagnosticReport +import org.hl7.fhir.r4.model.Practitioner +import org.hl7.fhir.r4.model.ServiceRequest +import spock.lang.Specification + + +class CopyOrcOrderProviderToObrOrderProviderTest extends Specification{ + + final String PRACTITIONER_EXTENSION_URL = "https://reportstream.cdc.gov/fhir/StructureDefinition/xcn-practitioner" + + def transformClass + + def setup() { + TestApplicationContext.reset() + TestApplicationContext.init() + TestApplicationContext.register(MetricMetadata, Mock(MetricMetadata)) + TestApplicationContext.injectRegisteredImplementations() + + transformClass = new CopyOrcOrderProviderToObrOrderProvider() + } + + def "should return when diagnostic report is null"() { + given: + def bundle = createBundle(null) + + when: + transformClass.transform(new HapiFhirResource(bundle), null) + + then: + def serviceRequest = bundle.getEntry().find { it.getResource() instanceof ServiceRequest } + serviceRequest == null + } + + def "should return when service request is null"() { + given: + final String FHIR_ORU_PATH = "../CA/007_CA_ORU_R01_CDPH_produced_UCSD2024-07-11-16-02-17-749_1_hl7_translation.fhir" + def bundle = createBundle(FHIR_ORU_PATH) + def serviceRequest = createServiceRequest(bundle) + def diagnosticReport = HapiHelper.getDiagnosticReport(bundle) + + serviceRequest.setBasedOn(null) + diagnosticReport.setBasedOn(null) + + when: + transformClass.transform(new HapiFhirResource(bundle), null) + + then: + def diagnosticReportInBundle = bundle.getEntry().find { it.getResource() instanceof DiagnosticReport } + diagnosticReportInBundle != null // DiagnosticReport should still exist + HapiHelper.getServiceRequest(diagnosticReport) == null + } + + def "should return when practitioner role is null"() { + given: + final String FHIR_ORU_PATH = "../CA/007_CA_ORU_R01_CDPH_produced_UCSD2024-07-11-16-02-17-749_1_hl7_translation.fhir" + def bundle = createBundle(FHIR_ORU_PATH) + def serviceRequest = createServiceRequest(bundle) + def diagnosticReport = HapiHelper.getDiagnosticReport(bundle) + + serviceRequest.setRequester(null) + + when: + transformClass.transform(new HapiFhirResource(bundle), null) + + then: + def diagnosticReportInBundle = bundle.getEntry().find { it.getResource() instanceof DiagnosticReport } + diagnosticReportInBundle != null // DiagnosticReport should still exist + HapiHelper.getServiceRequest(diagnosticReport) != null // ServiceRequest should still exist + HapiHelper.getPractitionerRole(serviceRequest) == null + } + + def "when both practitioner resources are populated ORC.12 overwrites OBR.16"() { + given: + final String EXPECTED_NPI = "1790743185" + final String EXPECTED_FIRST_NAME = "EUSTRATIA" + final String EXPECTED_LAST_NAME = "HUBBARD" + final String EXPECTED_NAME_TYPE_CODE = "NPI" + final String EXPECTED_IDENTIFIER_TYPE_CODE = null + final String FHIR_ORU_PATH = "../CA/007_CA_ORU_R01_CDPH_produced_UCSD2024-07-11-16-02-17-749_1_hl7_translation.fhir" + + def bundle = createBundle(FHIR_ORU_PATH) + def serviceRequest = createServiceRequest(bundle) + + expect: + evaluateOrc12Values(serviceRequest, EXPECTED_NPI, EXPECTED_FIRST_NAME, EXPECTED_LAST_NAME, EXPECTED_NAME_TYPE_CODE, EXPECTED_IDENTIFIER_TYPE_CODE) + evaluateObr16Values(serviceRequest, null, EXPECTED_FIRST_NAME, EXPECTED_LAST_NAME, null, null) + + when: + transformClass.transform(new HapiFhirResource(bundle), null) + + then: + evaluateOrc12Values(serviceRequest, EXPECTED_NPI, EXPECTED_FIRST_NAME, EXPECTED_LAST_NAME, EXPECTED_NAME_TYPE_CODE, EXPECTED_IDENTIFIER_TYPE_CODE) + evaluateObr16Values(serviceRequest, EXPECTED_NPI, EXPECTED_FIRST_NAME, EXPECTED_LAST_NAME, EXPECTED_NAME_TYPE_CODE, EXPECTED_IDENTIFIER_TYPE_CODE) + } + + def "when ORC-12 extension populated and OBR-16 extension not populated, ORC.12 is copied over"() { + given: + final String EXPECTED_NPI = "1790743185" + final String EXPECTED_FIRST_NAME = "EUSTRATIA" + final String EXPECTED_LAST_NAME = "HUBBARD" + final String EXPECTED_NAME_TYPE_CODE = null + final String EXPECTED_IDENTIFIER_TYPE_CODE = "NPI" + final String FHIR_ORU_PATH = "../CA/017_CA_ORU_R01_CDPH_empty_obr16_UCSD2024-07-11-16-02-17-749_1_hl7_translation.fhir" + + def bundle = createBundle(FHIR_ORU_PATH) + def serviceRequest = createServiceRequest(bundle) + + expect: + // ORC12 values to copy + evaluateOrc12Values(serviceRequest, EXPECTED_NPI, EXPECTED_FIRST_NAME, EXPECTED_LAST_NAME, EXPECTED_NAME_TYPE_CODE, EXPECTED_IDENTIFIER_TYPE_CODE) + + // OBR16 should not exist initially + def obr16Practitioner = getObr16ExtensionPractitioner(serviceRequest) + obr16Practitioner == null + + when: + transformClass.transform(new HapiFhirResource(bundle), null) + + then: + // ORC12 values should remain the same + evaluateOrc12Values(serviceRequest, EXPECTED_NPI, EXPECTED_FIRST_NAME, EXPECTED_LAST_NAME, EXPECTED_NAME_TYPE_CODE, EXPECTED_IDENTIFIER_TYPE_CODE) + // OBR16 values should be updated to match ORC12 + evaluateObr16Values(serviceRequest, EXPECTED_NPI, EXPECTED_FIRST_NAME, EXPECTED_LAST_NAME, EXPECTED_NAME_TYPE_CODE, EXPECTED_IDENTIFIER_TYPE_CODE) + } + + def "when ORC-12 extension not populated and OBR-16 extension is populated, there is no change"() { + given: + final String EXPECTED_NPI = null + final String EXPECTED_FIRST_NAME = "EUSTRATIA" + final String EXPECTED_LAST_NAME = "HUBBARD" + final String EXPECTED_NAME_TYPE_CODE = null + final String EXPECTED_IDENTIFIER_TYPE_CODE = null + final String FHIR_ORU_PATH = "../CA/018_CA_ORU_R01_CDPH_empty_orc12_UCSD2024-07-11-16-02-17-749_1_hl7_translation.fhir" + + def bundle = createBundle(FHIR_ORU_PATH) + def serviceRequest = createServiceRequest(bundle) + + expect: + evaluateOrc12Values(serviceRequest, null, null, null, null, null) + evaluateObr16Values(serviceRequest, EXPECTED_NPI, EXPECTED_FIRST_NAME, EXPECTED_LAST_NAME, EXPECTED_NAME_TYPE_CODE, EXPECTED_IDENTIFIER_TYPE_CODE) + + when: + transformClass.transform(new HapiFhirResource(bundle), null) + + then: + evaluateOrc12Values(serviceRequest, null, null, null, null, null) + evaluateObr16Values(serviceRequest, EXPECTED_NPI, EXPECTED_FIRST_NAME, EXPECTED_LAST_NAME, EXPECTED_NAME_TYPE_CODE, EXPECTED_IDENTIFIER_TYPE_CODE) + } + + def "when neither is populated, there is no change"() { + given: + final String FHIR_ORU_PATH = "../CA/019_CA_ORU_R01_CDPH_empty_orc12_obr16_UCSD2024-07-11-16-02-17-749_1_hl7_translation.fhir" + + def bundle = createBundle(FHIR_ORU_PATH) + def serviceRequest = createServiceRequest(bundle) + + expect: + evaluateOrc12IsNull(serviceRequest) + evaluateObr16IsNull(serviceRequest) + + when: + transformClass.transform(new HapiFhirResource(bundle), null) + + then: + evaluateOrc12IsNull(serviceRequest) + evaluateObr16IsNull(serviceRequest) + } + + Bundle createBundle(String fhirOruPath) { + if (fhirOruPath == null) { + // Return an empty Bundle if the path is null + return new Bundle() + } + + def fhirResource = ExamplesHelper.getExampleFhirResource(fhirOruPath) + return fhirResource.getUnderlyingResource() as Bundle + } + + ServiceRequest createServiceRequest(Bundle bundle) { + def diagnosticReport = HapiHelper.getDiagnosticReport(bundle) + return HapiHelper.getServiceRequest(diagnosticReport) + } + + def evaluateOrc12IsNull(ServiceRequest serviceRequest) { + def practitionerRole = HapiHelper.getPractitionerRole(serviceRequest) + HapiHelper.getPractitioner(practitionerRole) == null + } + + def evaluateOrc12Values( + ServiceRequest serviceRequest, + String expectedNpi, + String expectedFirstName, + String expectedLastName, + String expectedNameTypeCode, + String expectedIdentifierTypeCode) { + def practitionerRole = HapiHelper.getPractitionerRole(serviceRequest) + def practitioner = HapiHelper.getPractitioner(practitionerRole) + def xcnExtension = practitioner?.getExtensionByUrl(PRACTITIONER_EXTENSION_URL) + + practitioner.identifier[0]?.value == expectedNpi + xcnExtension.getExtensionByUrl("XCN.3")?.value?.toString() == expectedFirstName + practitioner.name[0]?.family == expectedLastName + xcnExtension.getExtensionByUrl("XCN.10")?.value?.toString() == expectedNameTypeCode + def codingSystem = practitioner.identifier[0]?.type?.coding + codingSystem == null || codingSystem[0]?.code == expectedIdentifierTypeCode + } + + def evaluateObr16IsNull(ServiceRequest serviceRequest) { + getObr16ExtensionPractitioner(serviceRequest) == null + } + + def evaluateObr16Values( + ServiceRequest serviceRequest, + String expectedNpi, + String expectedFirstName, + String expectedLastName, + String expectedNameTypeCode, + String expectedIdentifierTypeCode) { + def practitioner = getObr16ExtensionPractitioner(serviceRequest) + def xcnExtension = practitioner.getExtensionByUrl(PRACTITIONER_EXTENSION_URL) + + practitioner.identifier[0]?.value == expectedNpi + xcnExtension.getExtensionByUrl("XCN.3")?.value?.toString() == expectedFirstName + practitioner.name[0]?.family == expectedLastName + xcnExtension.getExtensionByUrl("XCN.10")?.value?.toString() == expectedNameTypeCode + def codingSystem = practitioner.identifier[0]?.type?.coding + codingSystem == null || codingSystem[0]?.code == expectedIdentifierTypeCode + } + + Practitioner getObr16ExtensionPractitioner (serviceRequest) { + def resource + try { + def extensionByUrl1 = serviceRequest.getExtensionByUrl(HapiHelper.EXTENSION_OBR_URL) + def extensionByUrl2 = extensionByUrl1.getExtensionByUrl(HapiHelper.EXTENSION_OBR16_DATA_TYPE.toString()) + def value = extensionByUrl2.value + resource = value.getResource() + return resource + } catch(Exception ignored) { + resource = null + return resource + } + } +} diff --git a/examples/CA/007_CA_ORU_R01_CDPH_produced_UCSD2024-07-11-16-02-17-749_2_fhir_transformation.fhir b/examples/CA/007_CA_ORU_R01_CDPH_produced_UCSD2024-07-11-16-02-17-749_2_fhir_transformation.fhir index e91125f6a..59869466b 100644 --- a/examples/CA/007_CA_ORU_R01_CDPH_produced_UCSD2024-07-11-16-02-17-749_2_fhir_transformation.fhir +++ b/examples/CA/007_CA_ORU_R01_CDPH_produced_UCSD2024-07-11-16-02-17-749_2_fhir_transformation.fhir @@ -1,12313 +1,12313 @@ { - "resourceType": "Bundle", - "id": "1721843660233276000.622013c3-e425-4a48-b721-8e6e63837128", - "meta": { - "lastUpdated": "2024-07-24T10:54:20.234-07:00" - }, - "identifier": { - "system": "https://reportstream.cdc.gov/prime-router", - "value": "243747623" - }, - "type": "message", - "timestamp": "2024-07-11T03:49:13.000-07:00", - "entry": [ - { - "fullUrl": "MessageHeader/a43f68e7-8a7b-3739-80c9-bfac26e59d90", - "resource": { - "resourceType": "MessageHeader", - "id": "a43f68e7-8a7b-3739-80c9-bfac26e59d90", - "meta": { - "tag": [ - { - "system": "http://terminology.hl7.org/CodeSystem/v2-0103", - "code": "T" - }, - { - "system": "http://localcodes.org/ETOR", - "code": "ETOR", - "display": "Processed by ETOR" - } - ] - }, - "extension": [ - { - "url": "https://reportstream.cdc.gov/fhir/StructureDefinition/msh-message-header", - "extension": [ - { - "url": "MSH.7", - "valueString": "20240711034913" - } - ] - } - ], - "eventCoding": { - "system": "http://terminology.hl7.org/CodeSystem/v2-0003", - "code": "R01", - "display": "ORU^R01" - }, - "destination": [ - { - "extension": [ - { - "url": "https://reportstream.cdc.gov/fhir/StructureDefinition/hl7v2Field", - "valueString": "MSH.5" - } - ], - "name": "EPIC", - "receiver": { - "reference": "Organization/1721843660242972000.7067ce9f-a65e-4004-947f-85506f21e12d" - } - } - ], - "sender": { - "reference": "Organization/1721843660240758000.fc0d42e1-6998-4cbe-865f-9f715521df97" - }, - "source": { - "extension": [ - { - "url": "https://reportstream.cdc.gov/fhir/StructureDefinition/namespace-id", - "valueString": "SISGDSP" - }, - { - "url": "https://reportstream.cdc.gov/fhir/StructureDefinition/hl7v2Field", - "valueString": "MSH.3" - } - ], - "name": "SISGDSP", - "_endpoint": { - "extension": [ - { - "url": "http://hl7.org/fhir/StructureDefinition/data-absent-reason", - "valueCode": "unknown" - } - ] - } - } - } - }, - { - "fullUrl": "Organization/1721843660240758000.fc0d42e1-6998-4cbe-865f-9f715521df97", - "resource": { - "resourceType": "Organization", - "id": "1721843660240758000.fc0d42e1-6998-4cbe-865f-9f715521df97", - "identifier": [ - { - "extension": [ - { - "url": "https://reportstream.cdc.gov/fhir/StructureDefinition/hl7v2Field", - "valueString": "HD.1" - } - ], - "value": "CDPH" - } - ] - } - }, - { - "fullUrl": "Organization/1721843660242972000.7067ce9f-a65e-4004-947f-85506f21e12d", - "resource": { - "resourceType": "Organization", - "id": "1721843660242972000.7067ce9f-a65e-4004-947f-85506f21e12d", - "extension": [ - { - "url": "https://reportstream.cdc.gov/fhir/StructureDefinition/hl7v2Field", - "valueString": "MSH.6" - } - ], - "identifier": [ - { - "extension": [ - { - "url": "https://reportstream.cdc.gov/fhir/StructureDefinition/hl7v2Field", - "valueString": "HD.1" - } - ], - "value": "R797" - } - ] - } - }, - { - "fullUrl": "Provenance/1721843660251922000.642c6d75-1afd-4d11-8a18-1e47ffe621ec", - "resource": { - "resourceType": "Provenance", - "id": "1721843660251922000.642c6d75-1afd-4d11-8a18-1e47ffe621ec", - "target": [ - { - "reference": "MessageHeader/a43f68e7-8a7b-3739-80c9-bfac26e59d90" - }, - { - "reference": "DiagnosticReport/1721843660616764000.226775ae-be0d-4edf-94f8-ee0f39f23e31" - }, - { - "reference": "DiagnosticReport/1721843660618927000.0aa28be2-1035-4a1c-896a-f98cad94e18a" - }, - { - "reference": "DiagnosticReport/1721843660621071000.1a0963f0-d974-41ca-aa3e-28decb62b30b" - }, - { - "reference": "DiagnosticReport/1721843660622855000.fb3f1181-5dcf-4283-89d2-2a81c2eeb59d" - }, - { - "reference": "DiagnosticReport/1721843660625461000.49681c6c-b3cb-4aa8-9c3a-eac75ba85799" - }, - { - "reference": "DiagnosticReport/1721843660627307000.0b3ba9ce-a5b7-4fd6-b062-ed1b7bb46d1f" - }, - { - "reference": "DiagnosticReport/1721843660630162000.1c55f8da-1883-4399-9749-9ec9a030e92a" - }, - { - "reference": "DiagnosticReport/1721843660632333000.5547683c-8b68-4d3b-9346-6bb7e0508895" - }, - { - "reference": "DiagnosticReport/1721843660634225000.41d82f5f-c783-4149-9f65-d940d1c09ac4" - }, - { - "reference": "DiagnosticReport/1721843660636052000.74c7c181-c852-4081-9c1d-12b8f112f8e7" - }, - { - "reference": "DiagnosticReport/1721843660637806000.b2dd680a-6d5d-42a7-96a0-a901b369ec0c" - }, - { - "reference": "DiagnosticReport/1721843660639462000.16af0783-955d-469c-af37-3ccf0a0f7a54" - }, - { - "reference": "DiagnosticReport/1721843660641190000.676a84a7-e601-4429-acd0-56c80dce20ac" - }, - { - "reference": "DiagnosticReport/1721843660642961000.6f8c7313-8d05-45b9-8178-f25e38b2f878" - }, - { - "reference": "DiagnosticReport/1721843660644712000.b1d91a21-b51c-4a3a-99d7-24074a96c986" - }, - { - "reference": "DiagnosticReport/1721843660646472000.07e9110e-faf1-40ec-bb79-a11b9763045c" - }, - { - "reference": "DiagnosticReport/1721843660648272000.4ca7e718-8cdf-4059-85e6-4b21d51011d2" - }, - { - "reference": "DiagnosticReport/1721843660650016000.e1809abc-361c-4cc2-b47b-9415e410fd0b" - }, - { - "reference": "DiagnosticReport/1721843660651926000.406b09e0-294f-40fc-8d39-84d0fd100aec" - }, - { - "reference": "DiagnosticReport/1721843660653708000.c5b9bb30-a2cd-4924-84e0-938a01a8e0ad" - } - ], - "recorded": "2024-07-11T03:49:13Z", - "activity": { - "coding": [ - { - "display": "ORU^R01^ORU_R01" - } - ] - }, - "agent": [ - { - "type": { - "coding": [ - { - "system": 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a/examples/CA/007_CA_ORU_R01_CDPH_produced_UCSD2024-07-11-16-02-17-749_3_hl7_translation_final.hl7 +++ b/examples/CA/007_CA_ORU_R01_CDPH_produced_UCSD2024-07-11-16-02-17-749_3_hl7_translation_final.hl7 @@ -1,110 +1,110 @@ -MSH|^~\&|SISGDSP|CDPH|EPIC|R797|20240711034913||ORU^R01|243747623|T|2.5.1 -PID|1||80009197||NICUABG^TESTONE||20240607|M||2076-8^Native Hawaiian or Other Pacific Islander||||||||||||2186-5^Not Hispanic or Latino||N|1 -NK1|1|NICUABG|MTH^Mother -ORC|RE|189609160^HospOrdNumber||7241234515^FormNumber||||||||1790743185^HUBBARD^EUSTRATIA^^^^^^^NPI|||||||||^^^^^^^^^R797|N 054TS ARALC, TS102 E^^SAN DIEGO^CA^99999-9999 -OBR|1|189609160^HospOrdNumber||54089-8^NB Screen Panel Patient AHIC^LN^CDPHGSPEAP|||202407111346|||||||||^HUBBARD^EUSTRATIA||||||20240711034913|||F -OBX|1|CE|57721-3^Reason for lab test in Dried blood spot^LN|1|LA12421-6^Initial screen^LN|||N|||F|||20240711034913 -OBX|2|CE|57718-9^Sample quality of Dried blood spot^LN|1|LA12432-3^Acceptable^LN|||N|||F|||20240711034913 -OBX|3|CE|57130-7^Newborn screening report - overall interpretation^LN|1|LA18944-1^Screen is out of range for at least one condition^LN|||N|||F|||20240711034913 -OBX|4|CE|57131-5^Newborn conditions with positive markers [Identifier] in Dried blood spot^LN|1|LA12532-0^BIO^LN|||N|||F|||20240711034913 -OBX|5|CE|57720-5^Newborn conditions with equivocal markers [Identifier] in Dried blood spot^LN|1|LA137-2^None^LN|||N|||F|||20240711034913 -OBX|6|TX|57724-7^Newborn screening short narrative summary^LN|1|ACTION REQUIRED\.br\\.br\NBS Testing Lab - COMMUNITY REG MEDICAL CENTER LAB \R\EG 4389EVA EESEN, TS054 E, FRESNO, CA 99999\.br\\.br\Genetic Disease Laboratory - GDL W 057DR HCLE, TS016 E, RICHMOND, CA 99999-9999\.br\\.br\Lab Director - Genetic Disease Laboratory, (510) 231-1790\.br\\.br\Duplicate\.br\\.br\Follow-up:\.br\\.br\Acyl Carnitine Panel: Reference Ranges for acylcarnitines are based on specimens collected on newborns who are less than 10 days old. \.br\\.br\Biotinidase Deficiency: This screen for Biotinidase Deficiency was positive. Another specimen MUST be collected on this infant. \.br\\.br\If you have any questions regarding these screening outcomes, please contact the Newborn Screening Staff at at . \.br\\.br\Methods and Limitations:\.br\\.br\Assays for ALD Tier-1, BD, CAH, CF, GAL, MS/MS Acylcarnitine and Amino Acid Panels, PCH, hemoglobinopathies, and SCID were performed at the testing laboratory specified on the front of this report. Assays for ALD Tier-2, CAH Tier-2, Pompe Disease Tier-1, MPS I Tier-1, and SMA were developed and/or optimized by the Genetic Disease Laboratory (GDL), and performed at GDL. Performance characteristics of these assays are determined by GDL. The SMA assay is designed to identify 95% of SMA patients who have homozygous deletions of the SMN1 gene on chromosome 5q. These assays have not been cleared or approved by the U.S. Food and Drug Administration (FDA). The FDA has determined that such clearance or approval is not necessary. The assays are used for clinical purposes. They should not be regarded as investigational or for research. GDL is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA-88) to perform high complexity genetic disease screening. \.br\Attention Healthcare Provider:\.br\\.br\\.br\|||N|||F|||20240711034913 -OBX|7|TX|57129-9^Full newborn screening summary report for display or printing^LN|1||||N|||F|||20240711034913 -OBX|8|ST|57716-3^State printed on filter paper card [Identifier] in NBS card^LN|1|CA|||N|||F|||20240711034913 -OBX|9|NM|8339-4^Birthweight^LN|1|3500|grams||N|||F|||20240711034913 -OBX|10|CE|57722-1^Birth plurality of Pregnancy^LN|1|LA12411-7^Singleton^LN|||N|||F|||20240711034913 -OBX|11|NM|73806-2^Newborn age in hours^LN|1|34|day(s)||N|||F|||20240711034913 -OBX|12|CE|57713-0^Infant NICU factors that affect newborn screening interpretation^LN|1|LA137-2^None^LN|||N|||F|||20240711034913 -OBX|13|CE|67704-7^Feeding types^LN|1|LA16914-6^Breast milk^LN|||N|||F|||20240711034913 -OBX|14|TX|^^^99717-5^Accession Number^L|1|193-08-269/21-2024-21|||N|||F|||20240711034913 -OBX|15|TX|62324-9^Post-discharge provider name^LN|1|EUSTRATIA HUBBARD|||N|||F|||20240711034913 -OBX|16|TX|62327-2^Post-discharge provider practice address^LN|1|N 054TS ARALC, TS102 E SAN DIEGO CA 99999-9999 USA|||N|||F|||20240711034913 -OBX|17|NM|47633-3^Glycine [Moles/volume] in Dried blood spot^LN|1|0.5|µmol/L||N|||F|||20240711034913 -OBX|18|NM|53150-9^Alanine+Beta Alanine+Sarcosine [Moles/volume] in Dried blood spot^LN|1|500|µmol/L|<1000|N|||F|||20240711034913 -OBX|19|NM|47799-2^Valine [Moles/volume] in Dried blood spot^LN|1|0.5|µmol/L||N|||F|||20240711034913 -OBX|20|NM|53151-7^Valine/Phenylalanine [Molar ratio] in Dried blood spot^LN|1|0.00645|{Ratio}|<4.3|N|||F|||20240711034913 -OBX|21|NM|53152-5^Alloisoleucine+Isoleucine+Leucine+Hydroxyproline^LN|1|125|µmol/L|<230|N|||F|||20240711034913 -OBX|22|NM|53154-1^Alloisoleucine+Isoleucine+Leucine+Hydroxyproline/Alanine [Molar ratio] in Dried blood spot^LN|1|0.65|{Ratio}|<1.35|N|||F|||20240711034913 -OBX|23|NM|29573-3^Phenylalanine [Moles/volume] in Dried blood spot^LN|1|77.5|µmol/L|<175|N|||F|||20240711034913 -OBX|24|NM|35572-7^Phenylalanine/Tyrosine [Molar ratio] in Dried blood spot^LN|1|0.75|{Ratio}|<2.6|N|||F|||20240711034913 -OBX|25|NM|35571-9^Tyrosine [Moles/volume] in Dried blood spot^LN|1|425|µmol/L|<680|N|||F|||20240711034913 -OBX|26|NM|53231-7^Succinylacetone [Moles/volume] in Dried blood spot^LN|1|2.25|µmol/L|<6.1|N|||F|||20240711034913 -OBX|27|NM|47700-0^Methionine [Moles/volume] in Dried blood spot^LN|1|27|µmol/L|6.3-100|N|||F|||20240711034913 -OBX|28|NM|42892-0^Citrulline [Moles/volume] in Dried blood spot^LN|1|16.25|µmol/L|5-49|N|||F|||20240711034913 -OBX|29|NM|54092-2^Citrulline/Arginine [Molar ratio] in Dried blood spot^LN|1|3|{Ratio}|<4.8|N|||F|||20240711034913 -OBX|30|NM|53155-8^Asparagine+Ornithine [Moles/volume] in Dried blood spot^LN|1|400|µmol/L|<800|N|||F|||20240711034913 -OBX|31|NM|75215-4^Ornithine/Citrulline [Molar ratio] in Dried blood spot^LN|1|0.5|{Ratio}||N|||F|||20240711034913 -OBX|32|NM|47562-4^Arginine [Moles/volume] in Dried blood spot^LN|1|25|µmol/L|<63|N|||F|||20240711034913 -OBX|33|NM|75214-7^Arginine/Ornithine [Molar ratio] in Dried blood spot^LN|1|0.7|{Ratio}|<1.9|N|||F|||20240711034913 -OBX|34|NM|47732-3^Proline [Moles/volume] in Dried blood spot^LN|1|750|µmol/L|<1500|N|||F|||20240711034913 -OBX|35|TX|57710-6^Amino acidemias newborn screening comment/discussion^LN|1|Negative|||N|||F|||20240711034913 -OBX|36|CE|58088-6^Acylcarnitine newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 -OBX|37|TX|58093-6^Acylcarnitine newborn screening comment/discussion^LN|1|Negative|||N|||F|||20240711034913 -OBX|38|NM|38481-8^Carnitine.free (C0)^LN|1|33|µmol/L|6.4-125|N|||F|||20240711034913 -OBX|39|NM|53235-8^Carnitine.free (C0)/Palmitoylcarnitine (C16)+Stearoylcarnitine (C18)^LN|1|37.5|{Ratio}|<70|N|||F|||20240711034913 -OBX|40|NM|50157-7^Acetylcarnitine (C2)^LN|1|20.38|µmol/L|10-80|N|||F|||20240711034913 -OBX|41|NM|75212-1^Malonylcarnitine (C3-DC)/Decanoylcarnitine (C10) [Molar ratio] in Dried blood spot^LN|1|0.62500|{Ratio}|<7.6|N|||F|||20240711034913 -OBX|42|NM|45211-0^Hexanoylcarnitine (C6)^LN|1|0.48|µmol/L|<0.95|N|||F|||20240711034913 -OBX|43|NM|53175-6^Octanoylcarnitine (C8)^LN|1|0.3|µmol/L|<0.45|N|||F|||20240711034913 -OBX|44|NM|53177-2^Octanoylcarnitine (C8)/Decanoylcarnitine (C10)^LN|1|0.5|{Ratio}||N|||F|||20240711034913 -OBX|45|NM|53174-9^Octenoylcarnitine (C8:1)^LN|1|0.35|µmol/L|<0.65|N|||F|||20240711034913 -OBX|46|NM|45197-1^Decanoylcarnitine (C10)^LN|1|0.32|µmol/L|<0.65|N|||F|||20240711034913 -OBX|47|NM|45198-9^Decenoylcarnitine (C10:1)^LN|1|0.22|µmol/L|<0.45|N|||F|||20240711034913 -OBX|48|NM|45199-7^Dodecanoylcarnitine (C12)^LN|1|1|µmol/L|<2|N|||F|||20240711034913 -OBX|49|NM|45200-3^Dodecenoylcarnitine (C12:1)^LN|1|0.5|µmol/L||N|||F|||20240711034913 -OBX|50|NM|53192-1^Tetradecanoylcarnitine (C14)^LN|1|0.6|µmol/L|<1.2|N|||F|||20240711034913 -OBX|51|NM|53191-3^Tetradecenoylcarnitine (C14:1)^LN|1|0.4|µmol/L|<0.9|N|||F|||20240711034913 -OBX|52|NM|53194-7^Tetradecenoylcarnitine (C14:1)/Dodecenoylcarnitine (C12:1)^LN|1|0.5|{Ratio}||N|||F|||20240711034913 -OBX|53|NM|53190-5^Tetradecadienoylcarnitine (C14:2)^LN|1|0.5|µmol/L||N|||F|||20240711034913 -OBX|54|NM|50281-5^3-Hydroxytetradecanoylcarnitine (C14-OH)^LN|1|0.1|µmol/L|<0.2|N|||F|||20240711034913 -OBX|55|NM|53199-6^Palmitoylcarnitine (C16)^LN|1|5|µmol/L|<12|N|||F|||20240711034913 -OBX|56|NM|53198-8^Palmitoleylcarnitine (C16:1)^LN|1|0.7|µmol/L|<1.4|N|||F|||20240711034913 -OBX|57|NM|50125-4^3-Hydroxypalmitoylcarnitine (C16-OH)^LN|1|0.05|µmol/L|<0.1|N|||F|||20240711034913 -OBX|58|NM|53201-0^3-Hydroxypalmitoylcarnitine (C16-OH)/Palmitoylcarnitine (C16)^LN|1|0.01000|{Ratio}|<0.07|N|||F|||20240711034913 -OBX|59|NM|53241-6^Stearoylcarnitine (C18)^LN|1|2|µmol/L|<3.5|N|||F|||20240711034913 -OBX|60|NM|53202-8^Oleoylcarnitine (C18:1)^LN|1|3.5|µmol/L|<7|N|||F|||20240711034913 -OBX|61|NM|45217-7^Linoleoylcarnitine (C18:2)^LN|1|0.5|µmol/L||N|||F|||20240711034913 -OBX|62|NM|50132-0^3-Hydroxystearoylcarnitine (C18-OH)^LN|1|0.05|µmol/L|<0.1|N|||F|||20240711034913 -OBX|63|NM|50113-0^3-Hydroxyoleoylcarnitine (C18:1-OH)^LN|1|0.05|µmol/L|<0.1|N|||F|||20240711034913 -OBX|64|NM|53160-8^Propionylcarnitine (C3)^LN|1|3.15|µmol/L|<7.9|N|||F|||20240711034913 -OBX|65|NM|53163-2^Propionylcarnitine (C3)/Acetylcarnitine (C2)^LN|1|0.15|{Ratio}|<0.42|N|||F|||20240711034913 -OBX|66|NM|67708-8^Malonylcarnitine (C3-DC)+3-Hydroxybutyrylcarnitine (C4-OH)^LN|1|0.2|µmol/L|<0.48|N|||F|||20240711034913 -OBX|67|NM|53166-5^Butyrylcarnitine+Isobutyrylcarnitine (C4)^LN|1|0.85|µmol/L|<1.7|N|||F|||20240711034913 -OBX|68|NM|45216-9^Isovalerylcarnitine+Methylbutyrylcarnitine (C5)^LN|1|0.5|µmol/L|<0.95|N|||F|||20240711034913 -OBX|69|NM|53240-8^Isovalerylcarnitine+Methylbutyrylcarnitine (C5)/Propionylcarnitine (C3)^LN|1|0.15873|{Ratio}|<0.38|N|||F|||20240711034913 -OBX|70|NM|53170-7^Tiglylcarnitine (C5:1)^LN|1|0.3|µmol/L|<0.5|N|||F|||20240711034913 -OBX|71|NM|50106-4^3-Hydroxyisovalerylcarnitine (C5-OH)^LN|1|0.45|µmol/L|<1.15|N|||F|||20240711034913 -OBX|72|NM|67710-4^Glutarylcarnitine (C5-DC)+3-Hydroxyhexanoylcarnitine (C6-OH)^LN|1|0.3|µmol/L|<0.38|N|||F|||20240711034913 -OBX|73|NM|75216-2^Glutarylcarnitine (C5-DC)/Malonylcarnitine (C3-DC) [Molar ratio] in Dried blood spot^LN|1|1.50000|{Ratio}|>0.1|N|||F|||20240711034913 -OBX|74|NM|48633-2^Trypsinogen I.free^LN|1|31.00|ng/mL|<69|N|||F|||20240711034913 -OBX|75|CE|46769-6^Cystic fibrosis newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 -OBX|76|TX|57707-2^Cystic fibrosis newborn screening comment/discussion^LN|1|Negative|||N|||F|||20240711034913 -OBX|77|NM|38473-5^17-Hydroxyprogesterone^LN|1|35|nmol/L|<85|N|||F|||20240711034913 -OBX|78|CE|46758-9^Congenital adrenal hyperplasia newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 -OBX|79|TX|57706-4^Congenital adrenal hyperplasia newborn screening comment-discussion^LN|1|Negative|||N|||F|||20240711034913 -OBX|80|NM|29575-8^Thyrotropin^LN|1|14.50|mIU/L|<29|N|||F|||20240711034913 -OBX|81|CE|46762-1^Congenital hypothyroidism newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 -OBX|82|TX|57705-6^Congenital hypothyroidism newborn screening comment-discussion^LN|1|Negative|||N|||F|||20240711034913 -OBX|83|NM|42906-8^Galactose 1 phosphate uridyl transferase^LN|1|55.00|enzyme units|>50|N|||F|||20240711034913 -OBX|84|CE|46737-3^Galactosemias newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 -OBX|85|TX|57704-9^Galactosemias newborn screening comment-discussion^LN|1|Negative|||N|||F|||20240711034913 -OBX|86|TX|54104-5^Hemoglobin pattern^LN|1|FA||||||F|||20240711034913 -OBX|87|TX|57703-1^Hemoglobin disorders newborn screening comment/discussion^LN|1|Usual hemoglobin pattern. These results assume no transfusion prior to testing and do not rule out the possibility of a thalassemia trait or rare hemoglobin variants.||||||F|||20240711034913 -OBX|88|NM|75217-0^Biotinidase [Enzymatic activity/volume] in Dried blood spot^LN|1|8.00|ERU|>10|L|||F|||20240711034913 -OBX|89|CE|46761-3^Biotinidase deficiency newborn screen interpretation^LN|1|LA18593-6^Out of range^LN|||A|||F|||20240711034913 -OBX|90|TX|57699-1^Biotinidase deficiency newborn screening comment-discussion^LN|1|Positive|||A|||F|||20240711034913 -OBX|91|NM|62320-7^T-cell receptor excision circle [#/volume] in Dried blood spot by Probe and target amplification method^LN|1|33|copies/µL|>18|N|||F|||20240711034913 -OBX|92|CE|62321-5^Severe combined immunodeficiency newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 -OBX|93|TX|62322-3^Severe combined immunodeficiency newborn screening comment-discussion^LN|1|Negative|||N|||F|||20240711034913 -OBX|94|NM|55827-0^Acid alpha glucosidase [Enzymatic activity/volume] in DBS^LN|1|12.923|µmol/L/h|>=2.079|N|||F|||20240711034913 -OBX|95|CE|63415-4^Pompe Disease deficiency newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 -OBX|96|TX|63416-2^Pompe Disease deficiency newborn screening comments-discussion^LN|1|Negative|||N|||F|||20240711034913 -OBX|97|NM|55909-6^Alpha-L-iduronidase [Enzymatic activity/volume] in DBS^LN|1|3.117|µmol/L/h|>=1.2204|N|||F|||20240711034913 -OBX|98|CE|79564-1^Mucopolysaccharidosis type I newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 -OBX|99|TX|79565-8^Mucopolysaccharidosis type I newborn screening comment-discussion^LN|1|Negative|||N|||F|||20240711034913 -OBX|100|TX|^^^99717-60^SMN1 Homozygous Deletion Analysis^L|1|Exon 7 Present||Exon 7 Present|N|||F|||20240711034913 -OBX|101|CE|92004-1^Spinal muscular atrophy newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 -OBX|102|TX|92003-3^Spinal muscular atrophy newborn screening comment-discussion^LN|1|SMA Negative|||N|||F|||20240711034913 -OBX|103|CE|^^^99717-32^Adrenoleukodystrophy deficiency newborn screening interpretation^L|1|LA18592-8^In range^LN|||N|||F|||20240711034913 -OBX|104|TX|^^^99717-33^Adrenoleukodystrophy deficiency newborn screening comments-discussion^L|1|Negative|||N|||F|||20240711034913 -OBX|105|NM|79321-6^Lysophosphatidylcholine(26:0) [Moles/volume] in Dried blood spot^LN|1|0.2|µmol/L|<0.47|N|||F|||20240711034913 +MSH|^~\&|SISGDSP|CDPH|EPIC|R797|20240711034913||ORU^R01|243747623|T|2.5.1 +PID|1||80009197||NICUABG^TESTONE||20240607|M||2076-8^Native Hawaiian or Other Pacific Islander||||||||||||2186-5^Not Hispanic or Latino||N|1 +NK1|1|NICUABG|MTH^Mother +ORC|RE|189609160^HospOrdNumber||7241234515^FormNumber||||||||1790743185^HUBBARD^EUSTRATIA^^^^^^^NPI|||||||||^^^^^^^^^R797|N 054TS ARALC, TS102 E^^SAN DIEGO^CA^99999-9999 +OBR|1|189609160^HospOrdNumber||54089-8^NB Screen Panel Patient AHIC^LN^CDPHGSPEAP|||202407111346|||||||||1790743185^HUBBARD^EUSTRATIA^^^^^^^NPI||||||20240711034913 +OBX|1|CE|57721-3^Reason for lab test in Dried blood spot^LN|1|LA12421-6^Initial screen^LN|||N|||F|||20240711034913 +OBX|2|CE|57718-9^Sample quality of Dried blood spot^LN|1|LA12432-3^Acceptable^LN|||N|||F|||20240711034913 +OBX|3|CE|57130-7^Newborn screening report - overall interpretation^LN|1|LA18944-1^Screen is out of range for at least one condition^LN|||N|||F|||20240711034913 +OBX|4|CE|57131-5^Newborn conditions with positive markers [Identifier] in Dried blood spot^LN|1|LA12532-0^BIO^LN|||N|||F|||20240711034913 +OBX|5|CE|57720-5^Newborn conditions with equivocal markers [Identifier] in Dried blood spot^LN|1|LA137-2^None^LN|||N|||F|||20240711034913 +OBX|6|TX|57724-7^Newborn screening short narrative summary^LN|1|ACTION REQUIRED\.br\\.br\NBS Testing Lab - COMMUNITY REG MEDICAL CENTER LAB \R\EG 4389EVA EESEN, TS054 E, FRESNO, CA 99999\.br\\.br\Genetic Disease Laboratory - GDL W 057DR HCLE, TS016 E, RICHMOND, CA 99999-9999\.br\\.br\Lab Director - Genetic Disease Laboratory, (510) 231-1790\.br\\.br\Duplicate\.br\\.br\Follow-up:\.br\\.br\Acyl Carnitine Panel: Reference Ranges for acylcarnitines are based on specimens collected on newborns who are less than 10 days old. \.br\\.br\Biotinidase Deficiency: This screen for Biotinidase Deficiency was positive. Another specimen MUST be collected on this infant. \.br\\.br\If you have any questions regarding these screening outcomes, please contact the Newborn Screening Staff at at . \.br\\.br\Methods and Limitations:\.br\\.br\Assays for ALD Tier-1, BD, CAH, CF, GAL, MS/MS Acylcarnitine and Amino Acid Panels, PCH, hemoglobinopathies, and SCID were performed at the testing laboratory specified on the front of this report. Assays for ALD Tier-2, CAH Tier-2, Pompe Disease Tier-1, MPS I Tier-1, and SMA were developed and/or optimized by the Genetic Disease Laboratory (GDL), and performed at GDL. Performance characteristics of these assays are determined by GDL. The SMA assay is designed to identify 95% of SMA patients who have homozygous deletions of the SMN1 gene on chromosome 5q. These assays have not been cleared or approved by the U.S. Food and Drug Administration (FDA). The FDA has determined that such clearance or approval is not necessary. The assays are used for clinical purposes. They should not be regarded as investigational or for research. GDL is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA-88) to perform high complexity genetic disease screening. \.br\Attention Healthcare Provider:\.br\\.br\\.br\|||N|||F|||20240711034913 +OBX|7|TX|57129-9^Full newborn screening summary report for display or printing^LN|1||||N|||F|||20240711034913 +OBX|8|ST|57716-3^State printed on filter paper card [Identifier] in NBS card^LN|1|CA|||N|||F|||20240711034913 +OBX|9|NM|8339-4^Birthweight^LN|1|3500|grams||N|||F|||20240711034913 +OBX|10|CE|57722-1^Birth plurality of Pregnancy^LN|1|LA12411-7^Singleton^LN|||N|||F|||20240711034913 +OBX|11|NM|73806-2^Newborn age in hours^LN|1|34|day(s)||N|||F|||20240711034913 +OBX|12|CE|57713-0^Infant NICU factors that affect newborn screening interpretation^LN|1|LA137-2^None^LN|||N|||F|||20240711034913 +OBX|13|CE|67704-7^Feeding types^LN|1|LA16914-6^Breast milk^LN|||N|||F|||20240711034913 +OBX|14|TX|^^^99717-5^Accession Number^L|1|193-08-269/21-2024-21|||N|||F|||20240711034913 +OBX|15|TX|62324-9^Post-discharge provider name^LN|1|EUSTRATIA HUBBARD|||N|||F|||20240711034913 +OBX|16|TX|62327-2^Post-discharge provider practice address^LN|1|N 054TS ARALC, TS102 E SAN DIEGO CA 99999-9999 USA|||N|||F|||20240711034913 +OBX|17|NM|47633-3^Glycine [Moles/volume] in Dried blood spot^LN|1|0.5|µmol/L||N|||F|||20240711034913 +OBX|18|NM|53150-9^Alanine+Beta Alanine+Sarcosine [Moles/volume] in Dried blood spot^LN|1|500|µmol/L|<1000|N|||F|||20240711034913 +OBX|19|NM|47799-2^Valine [Moles/volume] in Dried blood spot^LN|1|0.5|µmol/L||N|||F|||20240711034913 +OBX|20|NM|53151-7^Valine/Phenylalanine [Molar ratio] in Dried blood spot^LN|1|0.00645|{Ratio}|<4.3|N|||F|||20240711034913 +OBX|21|NM|53152-5^Alloisoleucine+Isoleucine+Leucine+Hydroxyproline^LN|1|125|µmol/L|<230|N|||F|||20240711034913 +OBX|22|NM|53154-1^Alloisoleucine+Isoleucine+Leucine+Hydroxyproline/Alanine [Molar ratio] in Dried blood spot^LN|1|0.65|{Ratio}|<1.35|N|||F|||20240711034913 +OBX|23|NM|29573-3^Phenylalanine [Moles/volume] in Dried blood spot^LN|1|77.5|µmol/L|<175|N|||F|||20240711034913 +OBX|24|NM|35572-7^Phenylalanine/Tyrosine [Molar ratio] in Dried blood spot^LN|1|0.75|{Ratio}|<2.6|N|||F|||20240711034913 +OBX|25|NM|35571-9^Tyrosine [Moles/volume] in Dried blood spot^LN|1|425|µmol/L|<680|N|||F|||20240711034913 +OBX|26|NM|53231-7^Succinylacetone [Moles/volume] in Dried blood spot^LN|1|2.25|µmol/L|<6.1|N|||F|||20240711034913 +OBX|27|NM|47700-0^Methionine [Moles/volume] in Dried blood spot^LN|1|27|µmol/L|6.3-100|N|||F|||20240711034913 +OBX|28|NM|42892-0^Citrulline [Moles/volume] in Dried blood spot^LN|1|16.25|µmol/L|5-49|N|||F|||20240711034913 +OBX|29|NM|54092-2^Citrulline/Arginine [Molar ratio] in Dried blood spot^LN|1|3|{Ratio}|<4.8|N|||F|||20240711034913 +OBX|30|NM|53155-8^Asparagine+Ornithine [Moles/volume] in Dried blood spot^LN|1|400|µmol/L|<800|N|||F|||20240711034913 +OBX|31|NM|75215-4^Ornithine/Citrulline [Molar ratio] in Dried blood spot^LN|1|0.5|{Ratio}||N|||F|||20240711034913 +OBX|32|NM|47562-4^Arginine [Moles/volume] in Dried blood spot^LN|1|25|µmol/L|<63|N|||F|||20240711034913 +OBX|33|NM|75214-7^Arginine/Ornithine [Molar ratio] in Dried blood spot^LN|1|0.7|{Ratio}|<1.9|N|||F|||20240711034913 +OBX|34|NM|47732-3^Proline [Moles/volume] in Dried blood spot^LN|1|750|µmol/L|<1500|N|||F|||20240711034913 +OBX|35|TX|57710-6^Amino acidemias newborn screening comment/discussion^LN|1|Negative|||N|||F|||20240711034913 +OBX|36|CE|58088-6^Acylcarnitine newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|37|TX|58093-6^Acylcarnitine newborn screening comment/discussion^LN|1|Negative|||N|||F|||20240711034913 +OBX|38|NM|38481-8^Carnitine.free (C0)^LN|1|33|µmol/L|6.4-125|N|||F|||20240711034913 +OBX|39|NM|53235-8^Carnitine.free (C0)/Palmitoylcarnitine (C16)+Stearoylcarnitine (C18)^LN|1|37.5|{Ratio}|<70|N|||F|||20240711034913 +OBX|40|NM|50157-7^Acetylcarnitine (C2)^LN|1|20.38|µmol/L|10-80|N|||F|||20240711034913 +OBX|41|NM|75212-1^Malonylcarnitine (C3-DC)/Decanoylcarnitine (C10) [Molar ratio] in Dried blood spot^LN|1|0.62500|{Ratio}|<7.6|N|||F|||20240711034913 +OBX|42|NM|45211-0^Hexanoylcarnitine (C6)^LN|1|0.48|µmol/L|<0.95|N|||F|||20240711034913 +OBX|43|NM|53175-6^Octanoylcarnitine (C8)^LN|1|0.3|µmol/L|<0.45|N|||F|||20240711034913 +OBX|44|NM|53177-2^Octanoylcarnitine (C8)/Decanoylcarnitine (C10)^LN|1|0.5|{Ratio}||N|||F|||20240711034913 +OBX|45|NM|53174-9^Octenoylcarnitine (C8:1)^LN|1|0.35|µmol/L|<0.65|N|||F|||20240711034913 +OBX|46|NM|45197-1^Decanoylcarnitine (C10)^LN|1|0.32|µmol/L|<0.65|N|||F|||20240711034913 +OBX|47|NM|45198-9^Decenoylcarnitine (C10:1)^LN|1|0.22|µmol/L|<0.45|N|||F|||20240711034913 +OBX|48|NM|45199-7^Dodecanoylcarnitine (C12)^LN|1|1|µmol/L|<2|N|||F|||20240711034913 +OBX|49|NM|45200-3^Dodecenoylcarnitine (C12:1)^LN|1|0.5|µmol/L||N|||F|||20240711034913 +OBX|50|NM|53192-1^Tetradecanoylcarnitine (C14)^LN|1|0.6|µmol/L|<1.2|N|||F|||20240711034913 +OBX|51|NM|53191-3^Tetradecenoylcarnitine (C14:1)^LN|1|0.4|µmol/L|<0.9|N|||F|||20240711034913 +OBX|52|NM|53194-7^Tetradecenoylcarnitine (C14:1)/Dodecenoylcarnitine (C12:1)^LN|1|0.5|{Ratio}||N|||F|||20240711034913 +OBX|53|NM|53190-5^Tetradecadienoylcarnitine (C14:2)^LN|1|0.5|µmol/L||N|||F|||20240711034913 +OBX|54|NM|50281-5^3-Hydroxytetradecanoylcarnitine (C14-OH)^LN|1|0.1|µmol/L|<0.2|N|||F|||20240711034913 +OBX|55|NM|53199-6^Palmitoylcarnitine (C16)^LN|1|5|µmol/L|<12|N|||F|||20240711034913 +OBX|56|NM|53198-8^Palmitoleylcarnitine (C16:1)^LN|1|0.7|µmol/L|<1.4|N|||F|||20240711034913 +OBX|57|NM|50125-4^3-Hydroxypalmitoylcarnitine (C16-OH)^LN|1|0.05|µmol/L|<0.1|N|||F|||20240711034913 +OBX|58|NM|53201-0^3-Hydroxypalmitoylcarnitine (C16-OH)/Palmitoylcarnitine (C16)^LN|1|0.01000|{Ratio}|<0.07|N|||F|||20240711034913 +OBX|59|NM|53241-6^Stearoylcarnitine (C18)^LN|1|2|µmol/L|<3.5|N|||F|||20240711034913 +OBX|60|NM|53202-8^Oleoylcarnitine (C18:1)^LN|1|3.5|µmol/L|<7|N|||F|||20240711034913 +OBX|61|NM|45217-7^Linoleoylcarnitine (C18:2)^LN|1|0.5|µmol/L||N|||F|||20240711034913 +OBX|62|NM|50132-0^3-Hydroxystearoylcarnitine (C18-OH)^LN|1|0.05|µmol/L|<0.1|N|||F|||20240711034913 +OBX|63|NM|50113-0^3-Hydroxyoleoylcarnitine (C18:1-OH)^LN|1|0.05|µmol/L|<0.1|N|||F|||20240711034913 +OBX|64|NM|53160-8^Propionylcarnitine (C3)^LN|1|3.15|µmol/L|<7.9|N|||F|||20240711034913 +OBX|65|NM|53163-2^Propionylcarnitine (C3)/Acetylcarnitine (C2)^LN|1|0.15|{Ratio}|<0.42|N|||F|||20240711034913 +OBX|66|NM|67708-8^Malonylcarnitine (C3-DC)+3-Hydroxybutyrylcarnitine (C4-OH)^LN|1|0.2|µmol/L|<0.48|N|||F|||20240711034913 +OBX|67|NM|53166-5^Butyrylcarnitine+Isobutyrylcarnitine (C4)^LN|1|0.85|µmol/L|<1.7|N|||F|||20240711034913 +OBX|68|NM|45216-9^Isovalerylcarnitine+Methylbutyrylcarnitine (C5)^LN|1|0.5|µmol/L|<0.95|N|||F|||20240711034913 +OBX|69|NM|53240-8^Isovalerylcarnitine+Methylbutyrylcarnitine (C5)/Propionylcarnitine (C3)^LN|1|0.15873|{Ratio}|<0.38|N|||F|||20240711034913 +OBX|70|NM|53170-7^Tiglylcarnitine (C5:1)^LN|1|0.3|µmol/L|<0.5|N|||F|||20240711034913 +OBX|71|NM|50106-4^3-Hydroxyisovalerylcarnitine (C5-OH)^LN|1|0.45|µmol/L|<1.15|N|||F|||20240711034913 +OBX|72|NM|67710-4^Glutarylcarnitine (C5-DC)+3-Hydroxyhexanoylcarnitine (C6-OH)^LN|1|0.3|µmol/L|<0.38|N|||F|||20240711034913 +OBX|73|NM|75216-2^Glutarylcarnitine (C5-DC)/Malonylcarnitine (C3-DC) [Molar ratio] in Dried blood spot^LN|1|1.50000|{Ratio}|>0.1|N|||F|||20240711034913 +OBX|74|NM|48633-2^Trypsinogen I.free^LN|1|31.00|ng/mL|<69|N|||F|||20240711034913 +OBX|75|CE|46769-6^Cystic fibrosis newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|76|TX|57707-2^Cystic fibrosis newborn screening comment/discussion^LN|1|Negative|||N|||F|||20240711034913 +OBX|77|NM|38473-5^17-Hydroxyprogesterone^LN|1|35|nmol/L|<85|N|||F|||20240711034913 +OBX|78|CE|46758-9^Congenital adrenal hyperplasia newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|79|TX|57706-4^Congenital adrenal hyperplasia newborn screening comment-discussion^LN|1|Negative|||N|||F|||20240711034913 +OBX|80|NM|29575-8^Thyrotropin^LN|1|14.50|mIU/L|<29|N|||F|||20240711034913 +OBX|81|CE|46762-1^Congenital hypothyroidism newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|82|TX|57705-6^Congenital hypothyroidism newborn screening comment-discussion^LN|1|Negative|||N|||F|||20240711034913 +OBX|83|NM|42906-8^Galactose 1 phosphate uridyl transferase^LN|1|55.00|enzyme units|>50|N|||F|||20240711034913 +OBX|84|CE|46737-3^Galactosemias newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|85|TX|57704-9^Galactosemias newborn screening comment-discussion^LN|1|Negative|||N|||F|||20240711034913 +OBX|86|TX|54104-5^Hemoglobin pattern^LN|1|FA||||||F|||20240711034913 +OBX|87|TX|57703-1^Hemoglobin disorders newborn screening comment/discussion^LN|1|Usual hemoglobin pattern. These results assume no transfusion prior to testing and do not rule out the possibility of a thalassemia trait or rare hemoglobin variants.||||||F|||20240711034913 +OBX|88|NM|75217-0^Biotinidase [Enzymatic activity/volume] in Dried blood spot^LN|1|8.00|ERU|>10|L|||F|||20240711034913 +OBX|89|CE|46761-3^Biotinidase deficiency newborn screen interpretation^LN|1|LA18593-6^Out of range^LN|||A|||F|||20240711034913 +OBX|90|TX|57699-1^Biotinidase deficiency newborn screening comment-discussion^LN|1|Positive|||A|||F|||20240711034913 +OBX|91|NM|62320-7^T-cell receptor excision circle [#/volume] in Dried blood spot by Probe and target amplification method^LN|1|33|copies/µL|>18|N|||F|||20240711034913 +OBX|92|CE|62321-5^Severe combined immunodeficiency newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|93|TX|62322-3^Severe combined immunodeficiency newborn screening comment-discussion^LN|1|Negative|||N|||F|||20240711034913 +OBX|94|NM|55827-0^Acid alpha glucosidase [Enzymatic activity/volume] in DBS^LN|1|12.923|µmol/L/h|>=2.079|N|||F|||20240711034913 +OBX|95|CE|63415-4^Pompe Disease deficiency newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|96|TX|63416-2^Pompe Disease deficiency newborn screening comments-discussion^LN|1|Negative|||N|||F|||20240711034913 +OBX|97|NM|55909-6^Alpha-L-iduronidase [Enzymatic activity/volume] in DBS^LN|1|3.117|µmol/L/h|>=1.2204|N|||F|||20240711034913 +OBX|98|CE|79564-1^Mucopolysaccharidosis type I newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|99|TX|79565-8^Mucopolysaccharidosis type I newborn screening comment-discussion^LN|1|Negative|||N|||F|||20240711034913 +OBX|100|TX|^^^99717-60^SMN1 Homozygous Deletion Analysis^L|1|Exon 7 Present||Exon 7 Present|N|||F|||20240711034913 +OBX|101|CE|92004-1^Spinal muscular atrophy newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|102|TX|92003-3^Spinal muscular atrophy newborn screening comment-discussion^LN|1|SMA Negative|||N|||F|||20240711034913 +OBX|103|CE|^^^99717-32^Adrenoleukodystrophy deficiency newborn screening interpretation^L|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|104|TX|^^^99717-33^Adrenoleukodystrophy deficiency newborn screening comments-discussion^L|1|Negative|||N|||F|||20240711034913 +OBX|105|NM|79321-6^Lysophosphatidylcholine(26:0) [Moles/volume] in Dried blood spot^LN|1|0.2|µmol/L|<0.47|N|||F|||20240711034913 diff --git a/examples/CA/017_CA_ORU_R01_CDPH_empty_obr16_UCSD2024-07-11-16-02-17-749_0_initial_message.hl7 b/examples/CA/017_CA_ORU_R01_CDPH_empty_obr16_UCSD2024-07-11-16-02-17-749_0_initial_message.hl7 new file mode 100644 index 000000000..3adfd154f --- /dev/null +++ b/examples/CA/017_CA_ORU_R01_CDPH_empty_obr16_UCSD2024-07-11-16-02-17-749_0_initial_message.hl7 @@ -0,0 +1,129 @@ +MSH|^~\&|SISGDSP|SISGDSP|SISHIERECEIVER^11903029^L,M,N|^^L,M,N|20240711034913||ORU^R01^ORU_R01|243747623|T|2.5.1 +PID|1||80009197^^^&NPI^MR||NICUABG^TESTONE^^^^^B||20240607|M||2076-8^Native Hawaiian or Other Pacific Islander||||||||||||2186-5^Not Hispanic or Latino||N|1 +NK1|1|NICUABG|MTH^Mother +ORC|RE|7241234515^FormNumber||189609160^HospOrdNumber||||||||1790743185^HUBBARD^EUSTRATIA^^^^^^^^^^NPI|||||||||^^^^^^^^^R797| N 054TS ARALC, TS102 E^^SAN DIEGO^CA^99999-9999 +OBR|1|7241234515^FormNumber||54089-8^NB Screen Panel Patient AHIC|||202407111346|||||||||||||||20240711034913|||F +OBR|2|7241234515^FormNumber||57128-1^Newborn Screening Report summary panel|||202407111346|||||||||||||||20240711034913|||F +OBX|1|CE|57721-3^Reason for lab test in Dried blood spot^LN|1|LA12421-6^Initial screen^LN|||N|||F|||20240711034913 +OBX|2|CE|57718-9^Sample quality of Dried blood spot^LN|1|LA12432-3^Acceptable^LN|||N|||F|||20240711034913 +OBX|3|CE|57130-7^Newborn screening report - overall interpretation^LN|1|LA18944-1^Screen is out of range for at least one condition^LN|||N|||F|||20240711034913 +OBX|4|CE|57131-5^Newborn conditions with positive markers [Identifier] in Dried blood spot^LN|1|LA12532-0^BIO^LN|||N|||F|||20240711034913 +OBX|5|CE|57720-5^Newborn conditions with equivocal markers [Identifier] in Dried blood spot^LN|1|LA137-2^None^LN|||N|||F|||20240711034913 +OBX|6|TX|57724-7^Newborn screening short narrative summary^LN|1|ACTION REQUIRED\.br\\.br\NBS Testing Lab - COMMUNITY REG MEDICAL CENTER LAB \R\EG 4389EVA EESEN, TS054 E, FRESNO, CA 99999\.br\\.br\Genetic Disease Laboratory - GDL W 057DR HCLE, TS016 E, RICHMOND, CA 99999-9999\.br\\.br\Lab Director - Genetic Disease Laboratory, (510) 231-1790\.br\\.br\Duplicate\.br\\.br\Follow-up:\.br\\.br\Acyl Carnitine Panel: Reference Ranges for acylcarnitines are based on specimens collected on newborns who are less than 10 days old. \.br\\.br\Biotinidase Deficiency: This screen for Biotinidase Deficiency was positive. Another specimen MUST be collected on this infant. \.br\\.br\If you have any questions regarding these screening outcomes, please contact the Newborn Screening Staff at at . \.br\\.br\Methods and Limitations:\.br\\.br\Assays for ALD Tier-1, BD, CAH, CF, GAL, MS/MS Acylcarnitine and Amino Acid Panels, PCH, hemoglobinopathies, and SCID were performed at the testing laboratory specified on the front of this report. Assays for ALD Tier-2, CAH Tier-2, Pompe Disease Tier-1, MPS I Tier-1, and SMA were developed and/or optimized by the Genetic Disease Laboratory (GDL), and performed at GDL. Performance characteristics of these assays are determined by GDL. The SMA assay is designed to identify 95% of SMA patients who have homozygous deletions of the SMN1 gene on chromosome 5q. These assays have not been cleared or approved by the U.S. Food and Drug Administration (FDA). The FDA has determined that such clearance or approval is not necessary. The assays are used for clinical purposes. They should not be regarded as investigational or for research. GDL is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA-88) to perform high complexity genetic disease screening. \.br\Attention Healthcare Provider:\.br\\.br\\.br\|||N|||F|||20240711034913 +OBX|7|TX|57129-9^Full newborn screening summary report for display or printing^LN|1||||N|||F|||20240711034913 +OBR|3|7241234515^FormNumber||57717-1^Newborn screen card data panel|||202407111346|||||||||||||||20240711034913|||F +OBX|1|ST|57716-3^State printed on filter paper card [Identifier] in NBS card^LN|1|CA|||N|||F|||20240711034913 +OBX|2|NM|8339-4^Birthweight^LN|1|3500|grams||N|||F|||20240711034913 +OBX|3|CE|57722-1^Birth plurality of Pregnancy^LN|1|LA12411-7^Singleton^LN|||N|||F|||20240711034913 +OBX|4|NM|73806-2^Newborn age in hours^LN|1|34|day(s)||N|||F|||20240711034913 +OBX|5|CE|57713-0^Infant NICU factors that affect newborn screening interpretation^LN|1|LA137-2^None^LN|||N|||F|||20240711034913 +OBX|6|CE|67704-7^Feeding types^LN|1|LA16914-6^Breast milk^LN|||N|||F|||20240711034913 +OBX|7|TX|^^^99717-5^Accession Number^L|1|193-08-269/21-2024-21|||N|||F|||20240711034913 +OBX|8|TX|62324-9^Post-discharge provider name^LN|1|EUSTRATIA HUBBARD|||N|||F|||20240711034913 +OBX|9|TX|62327-2^Post-discharge provider practice address^LN|1|N 054TS ARALC, TS102 E SAN DIEGO CA 99999-9999 USA|||N|||F|||20240711034913 +OBR|4|7241234515^FormNumber||57794-0^Newborn screening test results panel in Dried blood spot|||202407111346|||||||||||||||20240711034913|||F +OBR|5|7241234515^FormNumber||53261-4^Amino acid newborn screen panel|||202407111346|||||||||||||||20240711034913|||F +OBX|1|NM|47633-3^Glycine [Moles/volume] in Dried blood spot^LN|1|0.5|µmol/L||N|||F|||20240711034913 +OBX|2|NM|53150-9^Alanine+Beta Alanine+Sarcosine [Moles/volume] in Dried blood spot^LN|1|500|µmol/L|<1000|N|||F|||20240711034913 +OBX|3|NM|47799-2^Valine [Moles/volume] in Dried blood spot^LN|1|0.5|µmol/L||N|||F|||20240711034913 +OBX|4|NM|53151-7^Valine/Phenylalanine [Molar ratio] in Dried blood spot^LN|1|0.00645|{Ratio}|<4.3|N|||F|||20240711034913 +OBX|5|NM|53152-5^Alloisoleucine+Isoleucine+Leucine+Hydroxyproline^LN|1|125|µmol/L|<230|N|||F|||20240711034913 +OBX|6|NM|53154-1^Alloisoleucine+Isoleucine+Leucine+Hydroxyproline/Alanine [Molar ratio] in Dried blood spot^LN|1|0.65|{Ratio}|<1.35|N|||F|||20240711034913 +OBX|7|NM|29573-3^Phenylalanine [Moles/volume] in Dried blood spot^LN|1|77.5|µmol/L|<175|N|||F|||20240711034913 +OBX|8|NM|35572-7^Phenylalanine/Tyrosine [Molar ratio] in Dried blood spot^LN|1|0.75|{Ratio}|<2.6|N|||F|||20240711034913 +OBX|9|NM|35571-9^Tyrosine [Moles/volume] in Dried blood spot^LN|1|425|µmol/L|<680|N|||F|||20240711034913 +OBX|10|NM|53231-7^Succinylacetone [Moles/volume] in Dried blood spot^LN|1|2.25|µmol/L|<6.1|N|||F|||20240711034913 +OBX|11|NM|47700-0^Methionine [Moles/volume] in Dried blood spot^LN|1|27|µmol/L|6.3-100|N|||F|||20240711034913 +OBX|12|NM|42892-0^Citrulline [Moles/volume] in Dried blood spot^LN|1|16.25|µmol/L|5-49|N|||F|||20240711034913 +OBX|13|NM|54092-2^Citrulline/Arginine [Molar ratio] in Dried blood spot^LN|1|3|{Ratio}|<4.8|N|||F|||20240711034913 +OBX|14|NM|53155-8^Asparagine+Ornithine [Moles/volume] in Dried blood spot^LN|1|400|µmol/L|<800|N|||F|||20240711034913 +OBX|15|NM|75215-4^Ornithine/Citrulline [Molar ratio] in Dried blood spot^LN|1|0.5|{Ratio}||N|||F|||20240711034913 +OBX|16|NM|47562-4^Arginine [Moles/volume] in Dried blood spot^LN|1|25|µmol/L|<63|N|||F|||20240711034913 +OBX|17|NM|75214-7^Arginine/Ornithine [Molar ratio] in Dried blood spot^LN|1|0.7|{Ratio}|<1.9|N|||F|||20240711034913 +OBX|18|NM|47732-3^Proline [Moles/volume] in Dried blood spot^LN|1|750|µmol/L|<1500|N|||F|||20240711034913 +OBX|19|TX|57710-6^Amino acidemias newborn screening comment/discussion^LN|1|Negative|||N|||F|||20240711034913 +OBR|6|7241234515^FormNumber||58092-8^Acylcarnitine newborn screen panel|||202407111346|||||||||||||||20240711034913|||F +OBX|1|CE|58088-6^Acylcarnitine newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|2|TX|58093-6^Acylcarnitine newborn screening comment/discussion^LN|1|Negative|||N|||F|||20240711034913 +OBR|7|7241234515^FormNumber||57084-6^Fatty acid oxidation newborn screen panel|||202407111346|||||||||||||||20240711034913|||F +OBX|1|NM|38481-8^Carnitine.free (C0)^LN|1|33|µmol/L|6.4-125|N|||F|||20240711034913 +OBX|2|NM|53235-8^Carnitine.free (C0)/Palmitoylcarnitine (C16)+Stearoylcarnitine (C18)^LN|1|37.5|{Ratio}|<70|N|||F|||20240711034913 +OBX|3|NM|50157-7^Acetylcarnitine (C2)^LN|1|20.38|µmol/L|10-80|N|||F|||20240711034913 +OBX|4|NM|75212-1^Malonylcarnitine (C3-DC)/Decanoylcarnitine (C10) [Molar ratio] in Dried blood spot^LN|1|0.62500|{Ratio}|<7.6|N|||F|||20240711034913 +OBX|5|NM|45211-0^Hexanoylcarnitine (C6)^LN|1|0.48|µmol/L|<0.95|N|||F|||20240711034913 +OBX|6|NM|53175-6^Octanoylcarnitine (C8)^LN|1|0.3|µmol/L|<0.45|N|||F|||20240711034913 +OBX|7|NM|53177-2^Octanoylcarnitine (C8)/Decanoylcarnitine (C10)^LN|1|0.5|{Ratio}||N|||F|||20240711034913 +OBX|8|NM|53174-9^Octenoylcarnitine (C8:1)^LN|1|0.35|µmol/L|<0.65|N|||F|||20240711034913 +OBX|9|NM|45197-1^Decanoylcarnitine (C10)^LN|1|0.32|µmol/L|<0.65|N|||F|||20240711034913 +OBX|10|NM|45198-9^Decenoylcarnitine (C10:1)^LN|1|0.22|µmol/L|<0.45|N|||F|||20240711034913 +OBX|11|NM|45199-7^Dodecanoylcarnitine (C12)^LN|1|1|µmol/L|<2|N|||F|||20240711034913 +OBX|12|NM|45200-3^Dodecenoylcarnitine (C12:1)^LN|1|0.5|µmol/L||N|||F|||20240711034913 +OBX|13|NM|53192-1^Tetradecanoylcarnitine (C14)^LN|1|0.6|µmol/L|<1.2|N|||F|||20240711034913 +OBX|14|NM|53191-3^Tetradecenoylcarnitine (C14:1)^LN|1|0.4|µmol/L|<0.9|N|||F|||20240711034913 +OBX|15|NM|53194-7^Tetradecenoylcarnitine (C14:1)/Dodecenoylcarnitine (C12:1)^LN|1|0.5|{Ratio}||N|||F|||20240711034913 +OBX|16|NM|53190-5^Tetradecadienoylcarnitine (C14:2)^LN|1|0.5|µmol/L||N|||F|||20240711034913 +OBX|17|NM|50281-5^3-Hydroxytetradecanoylcarnitine (C14-OH)^LN|1|0.1|µmol/L|<0.2|N|||F|||20240711034913 +OBX|18|NM|53199-6^Palmitoylcarnitine (C16)^LN|1|5|µmol/L|<12|N|||F|||20240711034913 +OBX|19|NM|53198-8^Palmitoleylcarnitine (C16:1)^LN|1|0.7|µmol/L|<1.4|N|||F|||20240711034913 +OBX|20|NM|50125-4^3-Hydroxypalmitoylcarnitine (C16-OH)^LN|1|0.05|µmol/L|<0.1|N|||F|||20240711034913 +OBX|21|NM|53201-0^3-Hydroxypalmitoylcarnitine (C16-OH)/Palmitoylcarnitine (C16)^LN|1|0.01000|{Ratio}|<0.07|N|||F|||20240711034913 +OBX|22|NM|53241-6^Stearoylcarnitine (C18)^LN|1|2|µmol/L|<3.5|N|||F|||20240711034913 +OBX|23|NM|53202-8^Oleoylcarnitine (C18:1)^LN|1|3.5|µmol/L|<7|N|||F|||20240711034913 +OBX|24|NM|45217-7^Linoleoylcarnitine (C18:2)^LN|1|0.5|µmol/L||N|||F|||20240711034913 +OBX|25|NM|50132-0^3-Hydroxystearoylcarnitine (C18-OH)^LN|1|0.05|µmol/L|<0.1|N|||F|||20240711034913 +OBX|26|NM|50113-0^3-Hydroxyoleoylcarnitine (C18:1-OH)^LN|1|0.05|µmol/L|<0.1|N|||F|||20240711034913 +OBR|8|7241234515^FormNumber||57085-3^Organic acid newborn screen panel|||202407111346|||||||||||||||20240711034913|||F +OBX|1|NM|53160-8^Propionylcarnitine (C3)^LN|1|3.15|µmol/L|<7.9|N|||F|||20240711034913 +OBX|2|NM|53163-2^Propionylcarnitine (C3)/Acetylcarnitine (C2)^LN|1|0.15|{Ratio}|<0.42|N|||F|||20240711034913 +OBX|3|NM|67708-8^Malonylcarnitine (C3-DC)+3-Hydroxybutyrylcarnitine (C4-OH)^LN|1|0.2|µmol/L|<0.48|N|||F|||20240711034913 +OBX|4|NM|53166-5^Butyrylcarnitine+Isobutyrylcarnitine (C4)^LN|1|0.85|µmol/L|<1.7|N|||F|||20240711034913 +OBX|5|NM|45216-9^Isovalerylcarnitine+Methylbutyrylcarnitine (C5)^LN|1|0.5|µmol/L|<0.95|N|||F|||20240711034913 +OBX|6|NM|53240-8^Isovalerylcarnitine+Methylbutyrylcarnitine (C5)/Propionylcarnitine (C3)^LN|1|0.15873|{Ratio}|<0.38|N|||F|||20240711034913 +OBX|7|NM|53170-7^Tiglylcarnitine (C5:1)^LN|1|0.3|µmol/L|<0.5|N|||F|||20240711034913 +OBX|8|NM|50106-4^3-Hydroxyisovalerylcarnitine (C5-OH)^LN|1|0.45|µmol/L|<1.15|N|||F|||20240711034913 +OBX|9|NM|67710-4^Glutarylcarnitine (C5-DC)+3-Hydroxyhexanoylcarnitine (C6-OH)^LN|1|0.3|µmol/L|<0.38|N|||F|||20240711034913 +OBX|10|NM|75216-2^Glutarylcarnitine (C5-DC)/Malonylcarnitine (C3-DC) [Molar ratio] in Dried blood spot^LN|1|1.50000|{Ratio}|>0.1|N|||F|||20240711034913 +OBR|9|7241234515^FormNumber||54078-1^Cystic fibrosis newborn screening panel|||202407111346|||||||||||||||20240711034913|||F +OBX|1|NM|48633-2^Trypsinogen I.free^LN|1|31.00|ng/mL|<69|N|||F|||20240711034913 +OBX|2|CE|46769-6^Cystic fibrosis newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|3|TX|57707-2^Cystic fibrosis newborn screening comment/discussion^LN|1|Negative|||N|||F|||20240711034913 +OBR|10|7241234515^FormNumber||57086-1^Congenital adrenal hyperplasia newborn screening panel|||202407111346|||||||||||||||20240711034913|||F +OBX|1|NM|38473-5^17-Hydroxyprogesterone^LN|1|35|nmol/L|<85|N|||F|||20240711034913 +OBX|2|CE|46758-9^Congenital adrenal hyperplasia newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|3|TX|57706-4^Congenital adrenal hyperplasia newborn screening comment-discussion^LN|1|Negative|||N|||F|||20240711034913 +OBR|11|7241234515^FormNumber||54090-6^Thyroid newborn screening panel|||202407111346|||||||||||||||20240711034913|||F +OBX|1|NM|29575-8^Thyrotropin^LN|1|14.50|mIU/L|<29|N|||F|||20240711034913 +OBX|2|CE|46762-1^Congenital hypothyroidism newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|3|TX|57705-6^Congenital hypothyroidism newborn screening comment-discussion^LN|1|Negative|||N|||F|||20240711034913 +OBR|12|7241234515^FormNumber||54079-9^Galactosemia newborn screening panel|||202407111346|||||||||||||||20240711034913|||F +OBX|1|NM|42906-8^Galactose 1 phosphate uridyl transferase^LN|1|55.00|enzyme units|>50|N|||F|||20240711034913 +OBX|2|CE|46737-3^Galactosemias newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|3|TX|57704-9^Galactosemias newborn screening 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b/examples/CA/017_CA_ORU_R01_CDPH_empty_obr16_UCSD2024-07-11-16-02-17-749_3_hl7_translation_final.hl7 @@ -0,0 +1,110 @@ +MSH|^~\&|SISGDSP|CDPH|EPIC|R797|20240711034913||ORU^R01|243747623|T|2.5.1 +PID|1||80009197||NICUABG^TESTONE||20240607|M||2076-8^Native Hawaiian or Other Pacific Islander||||||||||||2186-5^Not Hispanic or Latino||N|1 +NK1|1|NICUABG|MTH^Mother +ORC|RE|189609160^HospOrdNumber||7241234515^FormNumber||||||||1790743185^HUBBARD^EUSTRATIA^^^^^^^^^^NPI|||||||||^^^^^^^^^R797|N 054TS ARALC, TS102 E^^SAN DIEGO^CA^99999-9999 +OBR|1|189609160^HospOrdNumber||54089-8^NB Screen Panel Patient AHIC^LN^CDPHGSPEAP|||202407111346|||||||||1790743185^HUBBARD^EUSTRATIA^^^^^^^^^^NPI||||||20240711034913|||F +OBX|1|CE|57721-3^Reason for lab test in Dried blood spot^LN|1|LA12421-6^Initial screen^LN|||N|||F|||20240711034913 +OBX|2|CE|57718-9^Sample quality of Dried blood spot^LN|1|LA12432-3^Acceptable^LN|||N|||F|||20240711034913 +OBX|3|CE|57130-7^Newborn screening report - overall interpretation^LN|1|LA18944-1^Screen is out of range for at least one condition^LN|||N|||F|||20240711034913 +OBX|4|CE|57131-5^Newborn conditions with positive markers [Identifier] in Dried blood spot^LN|1|LA12532-0^BIO^LN|||N|||F|||20240711034913 +OBX|5|CE|57720-5^Newborn conditions with equivocal markers [Identifier] in Dried blood spot^LN|1|LA137-2^None^LN|||N|||F|||20240711034913 +OBX|6|TX|57724-7^Newborn screening short narrative summary^LN|1|ACTION REQUIRED\.br\\.br\NBS Testing Lab - COMMUNITY REG MEDICAL CENTER LAB \R\EG 4389EVA EESEN, TS054 E, FRESNO, CA 99999\.br\\.br\Genetic Disease Laboratory - GDL W 057DR HCLE, TS016 E, RICHMOND, CA 99999-9999\.br\\.br\Lab Director - Genetic Disease Laboratory, (510) 231-1790\.br\\.br\Duplicate\.br\\.br\Follow-up:\.br\\.br\Acyl Carnitine Panel: Reference Ranges for acylcarnitines are based on specimens collected on newborns who are less than 10 days old. \.br\\.br\Biotinidase Deficiency: This screen for Biotinidase Deficiency was positive. Another specimen MUST be collected on this infant. \.br\\.br\If you have any questions regarding these screening outcomes, please contact the Newborn Screening Staff at at . \.br\\.br\Methods and Limitations:\.br\\.br\Assays for ALD Tier-1, BD, CAH, CF, GAL, MS/MS Acylcarnitine and Amino Acid Panels, PCH, hemoglobinopathies, and SCID were performed at the testing laboratory specified on the front of this report. Assays for ALD Tier-2, CAH Tier-2, Pompe Disease Tier-1, MPS I Tier-1, and SMA were developed and/or optimized by the Genetic Disease Laboratory (GDL), and performed at GDL. Performance characteristics of these assays are determined by GDL. The SMA assay is designed to identify 95% of SMA patients who have homozygous deletions of the SMN1 gene on chromosome 5q. These assays have not been cleared or approved by the U.S. Food and Drug Administration (FDA). The FDA has determined that such clearance or approval is not necessary. The assays are used for clinical purposes. They should not be regarded as investigational or for research. 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+OBX|15|TX|62324-9^Post-discharge provider name^LN|1|EUSTRATIA HUBBARD|||N|||F|||20240711034913 +OBX|16|TX|62327-2^Post-discharge provider practice address^LN|1|N 054TS ARALC, TS102 E SAN DIEGO CA 99999-9999 USA|||N|||F|||20240711034913 +OBX|17|NM|47633-3^Glycine [Moles/volume] in Dried blood spot^LN|1|0.5|µmol/L||N|||F|||20240711034913 +OBX|18|NM|53150-9^Alanine+Beta Alanine+Sarcosine [Moles/volume] in Dried blood spot^LN|1|500|µmol/L|<1000|N|||F|||20240711034913 +OBX|19|NM|47799-2^Valine [Moles/volume] in Dried blood spot^LN|1|0.5|µmol/L||N|||F|||20240711034913 +OBX|20|NM|53151-7^Valine/Phenylalanine [Molar ratio] in Dried blood spot^LN|1|0.00645|{Ratio}|<4.3|N|||F|||20240711034913 +OBX|21|NM|53152-5^Alloisoleucine+Isoleucine+Leucine+Hydroxyproline^LN|1|125|µmol/L|<230|N|||F|||20240711034913 +OBX|22|NM|53154-1^Alloisoleucine+Isoleucine+Leucine+Hydroxyproline/Alanine [Molar ratio] in Dried blood spot^LN|1|0.65|{Ratio}|<1.35|N|||F|||20240711034913 +OBX|23|NM|29573-3^Phenylalanine [Moles/volume] in Dried blood spot^LN|1|77.5|µmol/L|<175|N|||F|||20240711034913 +OBX|24|NM|35572-7^Phenylalanine/Tyrosine [Molar ratio] in Dried blood spot^LN|1|0.75|{Ratio}|<2.6|N|||F|||20240711034913 +OBX|25|NM|35571-9^Tyrosine [Moles/volume] in Dried blood spot^LN|1|425|µmol/L|<680|N|||F|||20240711034913 +OBX|26|NM|53231-7^Succinylacetone [Moles/volume] in Dried blood spot^LN|1|2.25|µmol/L|<6.1|N|||F|||20240711034913 +OBX|27|NM|47700-0^Methionine [Moles/volume] in Dried blood spot^LN|1|27|µmol/L|6.3-100|N|||F|||20240711034913 +OBX|28|NM|42892-0^Citrulline [Moles/volume] in Dried blood spot^LN|1|16.25|µmol/L|5-49|N|||F|||20240711034913 +OBX|29|NM|54092-2^Citrulline/Arginine [Molar ratio] in Dried blood spot^LN|1|3|{Ratio}|<4.8|N|||F|||20240711034913 +OBX|30|NM|53155-8^Asparagine+Ornithine [Moles/volume] in Dried blood spot^LN|1|400|µmol/L|<800|N|||F|||20240711034913 +OBX|31|NM|75215-4^Ornithine/Citrulline [Molar ratio] in Dried blood spot^LN|1|0.5|{Ratio}||N|||F|||20240711034913 +OBX|32|NM|47562-4^Arginine [Moles/volume] in Dried blood spot^LN|1|25|µmol/L|<63|N|||F|||20240711034913 +OBX|33|NM|75214-7^Arginine/Ornithine [Molar ratio] in Dried blood spot^LN|1|0.7|{Ratio}|<1.9|N|||F|||20240711034913 +OBX|34|NM|47732-3^Proline [Moles/volume] in Dried blood spot^LN|1|750|µmol/L|<1500|N|||F|||20240711034913 +OBX|35|TX|57710-6^Amino acidemias newborn screening comment/discussion^LN|1|Negative|||N|||F|||20240711034913 +OBX|36|CE|58088-6^Acylcarnitine newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|37|TX|58093-6^Acylcarnitine newborn screening comment/discussion^LN|1|Negative|||N|||F|||20240711034913 +OBX|38|NM|38481-8^Carnitine.free (C0)^LN|1|33|µmol/L|6.4-125|N|||F|||20240711034913 +OBX|39|NM|53235-8^Carnitine.free (C0)/Palmitoylcarnitine (C16)+Stearoylcarnitine (C18)^LN|1|37.5|{Ratio}|<70|N|||F|||20240711034913 +OBX|40|NM|50157-7^Acetylcarnitine (C2)^LN|1|20.38|µmol/L|10-80|N|||F|||20240711034913 +OBX|41|NM|75212-1^Malonylcarnitine (C3-DC)/Decanoylcarnitine (C10) [Molar ratio] in Dried blood spot^LN|1|0.625|{Ratio}|<7.6|N|||F|||20240711034913 +OBX|42|NM|45211-0^Hexanoylcarnitine (C6)^LN|1|0.48|µmol/L|<0.95|N|||F|||20240711034913 +OBX|43|NM|53175-6^Octanoylcarnitine (C8)^LN|1|0.3|µmol/L|<0.45|N|||F|||20240711034913 +OBX|44|NM|53177-2^Octanoylcarnitine (C8)/Decanoylcarnitine (C10)^LN|1|0.5|{Ratio}||N|||F|||20240711034913 +OBX|45|NM|53174-9^Octenoylcarnitine (C8:1)^LN|1|0.35|µmol/L|<0.65|N|||F|||20240711034913 +OBX|46|NM|45197-1^Decanoylcarnitine (C10)^LN|1|0.32|µmol/L|<0.65|N|||F|||20240711034913 +OBX|47|NM|45198-9^Decenoylcarnitine (C10:1)^LN|1|0.22|µmol/L|<0.45|N|||F|||20240711034913 +OBX|48|NM|45199-7^Dodecanoylcarnitine (C12)^LN|1|1|µmol/L|<2|N|||F|||20240711034913 +OBX|49|NM|45200-3^Dodecenoylcarnitine (C12:1)^LN|1|0.5|µmol/L||N|||F|||20240711034913 +OBX|50|NM|53192-1^Tetradecanoylcarnitine (C14)^LN|1|0.6|µmol/L|<1.2|N|||F|||20240711034913 +OBX|51|NM|53191-3^Tetradecenoylcarnitine (C14:1)^LN|1|0.4|µmol/L|<0.9|N|||F|||20240711034913 +OBX|52|NM|53194-7^Tetradecenoylcarnitine (C14:1)/Dodecenoylcarnitine (C12:1)^LN|1|0.5|{Ratio}||N|||F|||20240711034913 +OBX|53|NM|53190-5^Tetradecadienoylcarnitine (C14:2)^LN|1|0.5|µmol/L||N|||F|||20240711034913 +OBX|54|NM|50281-5^3-Hydroxytetradecanoylcarnitine (C14-OH)^LN|1|0.1|µmol/L|<0.2|N|||F|||20240711034913 +OBX|55|NM|53199-6^Palmitoylcarnitine (C16)^LN|1|5|µmol/L|<12|N|||F|||20240711034913 +OBX|56|NM|53198-8^Palmitoleylcarnitine (C16:1)^LN|1|0.7|µmol/L|<1.4|N|||F|||20240711034913 +OBX|57|NM|50125-4^3-Hydroxypalmitoylcarnitine (C16-OH)^LN|1|0.05|µmol/L|<0.1|N|||F|||20240711034913 +OBX|58|NM|53201-0^3-Hydroxypalmitoylcarnitine (C16-OH)/Palmitoylcarnitine (C16)^LN|1|0.01|{Ratio}|<0.07|N|||F|||20240711034913 +OBX|59|NM|53241-6^Stearoylcarnitine (C18)^LN|1|2|µmol/L|<3.5|N|||F|||20240711034913 +OBX|60|NM|53202-8^Oleoylcarnitine (C18:1)^LN|1|3.5|µmol/L|<7|N|||F|||20240711034913 +OBX|61|NM|45217-7^Linoleoylcarnitine (C18:2)^LN|1|0.5|µmol/L||N|||F|||20240711034913 +OBX|62|NM|50132-0^3-Hydroxystearoylcarnitine (C18-OH)^LN|1|0.05|µmol/L|<0.1|N|||F|||20240711034913 +OBX|63|NM|50113-0^3-Hydroxyoleoylcarnitine (C18:1-OH)^LN|1|0.05|µmol/L|<0.1|N|||F|||20240711034913 +OBX|64|NM|53160-8^Propionylcarnitine (C3)^LN|1|3.15|µmol/L|<7.9|N|||F|||20240711034913 +OBX|65|NM|53163-2^Propionylcarnitine (C3)/Acetylcarnitine (C2)^LN|1|0.15|{Ratio}|<0.42|N|||F|||20240711034913 +OBX|66|NM|67708-8^Malonylcarnitine (C3-DC)+3-Hydroxybutyrylcarnitine (C4-OH)^LN|1|0.2|µmol/L|<0.48|N|||F|||20240711034913 +OBX|67|NM|53166-5^Butyrylcarnitine+Isobutyrylcarnitine (C4)^LN|1|0.85|µmol/L|<1.7|N|||F|||20240711034913 +OBX|68|NM|45216-9^Isovalerylcarnitine+Methylbutyrylcarnitine (C5)^LN|1|0.5|µmol/L|<0.95|N|||F|||20240711034913 +OBX|69|NM|53240-8^Isovalerylcarnitine+Methylbutyrylcarnitine (C5)/Propionylcarnitine (C3)^LN|1|0.15873|{Ratio}|<0.38|N|||F|||20240711034913 +OBX|70|NM|53170-7^Tiglylcarnitine (C5:1)^LN|1|0.3|µmol/L|<0.5|N|||F|||20240711034913 +OBX|71|NM|50106-4^3-Hydroxyisovalerylcarnitine (C5-OH)^LN|1|0.45|µmol/L|<1.15|N|||F|||20240711034913 +OBX|72|NM|67710-4^Glutarylcarnitine (C5-DC)+3-Hydroxyhexanoylcarnitine (C6-OH)^LN|1|0.3|µmol/L|<0.38|N|||F|||20240711034913 +OBX|73|NM|75216-2^Glutarylcarnitine (C5-DC)/Malonylcarnitine (C3-DC) [Molar ratio] in Dried blood spot^LN|1|1.5|{Ratio}|>0.1|N|||F|||20240711034913 +OBX|74|NM|48633-2^Trypsinogen I.free^LN|1|31.0|ng/mL|<69|N|||F|||20240711034913 +OBX|75|CE|46769-6^Cystic fibrosis newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|76|TX|57707-2^Cystic fibrosis newborn screening comment/discussion^LN|1|Negative|||N|||F|||20240711034913 +OBX|77|NM|38473-5^17-Hydroxyprogesterone^LN|1|35|nmol/L|<85|N|||F|||20240711034913 +OBX|78|CE|46758-9^Congenital adrenal hyperplasia newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|79|TX|57706-4^Congenital adrenal hyperplasia newborn screening comment-discussion^LN|1|Negative|||N|||F|||20240711034913 +OBX|80|NM|29575-8^Thyrotropin^LN|1|14.5|mIU/L|<29|N|||F|||20240711034913 +OBX|81|CE|46762-1^Congenital hypothyroidism newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|82|TX|57705-6^Congenital hypothyroidism newborn screening comment-discussion^LN|1|Negative|||N|||F|||20240711034913 +OBX|83|NM|42906-8^Galactose 1 phosphate uridyl transferase^LN|1|55.0|enzyme units|>50|N|||F|||20240711034913 +OBX|84|CE|46737-3^Galactosemias newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|85|TX|57704-9^Galactosemias newborn screening comment-discussion^LN|1|Negative|||N|||F|||20240711034913 +OBX|86|TX|54104-5^Hemoglobin pattern^LN|1|FA||||||F|||20240711034913 +OBX|87|TX|57703-1^Hemoglobin disorders newborn screening comment/discussion^LN|1|Usual hemoglobin pattern. These results assume no transfusion prior to testing and do not rule out the possibility of a thalassemia trait or rare hemoglobin variants.||||||F|||20240711034913 +OBX|88|NM|75217-0^Biotinidase [Enzymatic activity/volume] in Dried blood spot^LN|1|8.0|ERU|>10|L|||F|||20240711034913 +OBX|89|CE|46761-3^Biotinidase deficiency newborn screen interpretation^LN|1|LA18593-6^Out of range^LN|||A|||F|||20240711034913 +OBX|90|TX|57699-1^Biotinidase deficiency newborn screening comment-discussion^LN|1|Positive|||A|||F|||20240711034913 +OBX|91|NM|62320-7^T-cell receptor excision circle [#/volume] in Dried blood spot by Probe and target amplification method^LN|1|33|copies/µL|>18|N|||F|||20240711034913 +OBX|92|CE|62321-5^Severe combined immunodeficiency newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|93|TX|62322-3^Severe combined immunodeficiency newborn screening comment-discussion^LN|1|Negative|||N|||F|||20240711034913 +OBX|94|NM|55827-0^Acid alpha glucosidase [Enzymatic activity/volume] in DBS^LN|1|12.923|µmol/L/h|>=2.079|N|||F|||20240711034913 +OBX|95|CE|63415-4^Pompe Disease deficiency newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|96|TX|63416-2^Pompe Disease deficiency newborn screening comments-discussion^LN|1|Negative|||N|||F|||20240711034913 +OBX|97|NM|55909-6^Alpha-L-iduronidase [Enzymatic activity/volume] in DBS^LN|1|3.117|µmol/L/h|>=1.2204|N|||F|||20240711034913 +OBX|98|CE|79564-1^Mucopolysaccharidosis type I newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|99|TX|79565-8^Mucopolysaccharidosis type I newborn screening comment-discussion^LN|1|Negative|||N|||F|||20240711034913 +OBX|100|TX|^^^99717-60^SMN1 Homozygous Deletion Analysis^L|1|Exon 7 Present||Exon 7 Present|N|||F|||20240711034913 +OBX|101|CE|92004-1^Spinal muscular atrophy newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|102|TX|92003-3^Spinal muscular atrophy newborn screening comment-discussion^LN|1|SMA Negative|||N|||F|||20240711034913 +OBX|103|CE|^^^99717-32^Adrenoleukodystrophy deficiency newborn screening interpretation^L|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|104|TX|^^^99717-33^Adrenoleukodystrophy deficiency newborn screening comments-discussion^L|1|Negative|||N|||F|||20240711034913 +OBX|105|NM|79321-6^Lysophosphatidylcholine(26:0) [Moles/volume] in Dried blood spot^LN|1|0.2|µmol/L|<0.47|N|||F|||20240711034913 diff --git a/examples/CA/018_CA_ORU_R01_CDPH_empty_orc12_UCSD2024-07-11-16-02-17-749_0_initial_message.hl7 b/examples/CA/018_CA_ORU_R01_CDPH_empty_orc12_UCSD2024-07-11-16-02-17-749_0_initial_message.hl7 new file mode 100644 index 000000000..11bb742d0 --- /dev/null +++ b/examples/CA/018_CA_ORU_R01_CDPH_empty_orc12_UCSD2024-07-11-16-02-17-749_0_initial_message.hl7 @@ -0,0 +1,129 @@ +MSH|^~\&|SISGDSP|SISGDSP|SISHIERECEIVER^11903029^L,M,N|^^L,M,N|20240711034913||ORU^R01^ORU_R01|243747623|T|2.5.1 +PID|1||80009197^^^&NPI^MR||NICUABG^TESTONE^^^^^B||20240607|M||2076-8^Native Hawaiian or Other Pacific Islander||||||||||||2186-5^Not Hispanic or Latino||N|1 +NK1|1|NICUABG|MTH^Mother +ORC|RE|7241234515^FormNumber||189609160^HospOrdNumber|||||||||||||||||^^^^^^^^^R797| N 054TS ARALC, TS102 E^^SAN DIEGO^CA^99999-9999 +OBR|1|7241234515^FormNumber||54089-8^NB Screen Panel Patient AHIC|||202407111346|||||||||^HUBBARD^EUSTRATIA||||||20240711034913|||F +OBR|2|7241234515^FormNumber||57128-1^Newborn Screening Report summary panel|||202407111346|||||||||^HUBBARD^EUSTRATIA||||||20240711034913|||F +OBX|1|CE|57721-3^Reason for lab test in Dried blood spot^LN|1|LA12421-6^Initial screen^LN|||N|||F|||20240711034913 +OBX|2|CE|57718-9^Sample quality of Dried blood spot^LN|1|LA12432-3^Acceptable^LN|||N|||F|||20240711034913 +OBX|3|CE|57130-7^Newborn screening report - overall interpretation^LN|1|LA18944-1^Screen is out of range for at least one condition^LN|||N|||F|||20240711034913 +OBX|4|CE|57131-5^Newborn conditions with positive markers [Identifier] in Dried blood spot^LN|1|LA12532-0^BIO^LN|||N|||F|||20240711034913 +OBX|5|CE|57720-5^Newborn conditions with equivocal markers [Identifier] in Dried blood spot^LN|1|LA137-2^None^LN|||N|||F|||20240711034913 +OBX|6|TX|57724-7^Newborn screening short narrative summary^LN|1|ACTION REQUIRED\.br\\.br\NBS Testing Lab - COMMUNITY REG MEDICAL CENTER LAB \R\EG 4389EVA EESEN, TS054 E, FRESNO, CA 99999\.br\\.br\Genetic Disease Laboratory - GDL W 057DR HCLE, TS016 E, RICHMOND, CA 99999-9999\.br\\.br\Lab Director - Genetic Disease Laboratory, (510) 231-1790\.br\\.br\Duplicate\.br\\.br\Follow-up:\.br\\.br\Acyl Carnitine Panel: Reference Ranges for acylcarnitines are based on specimens collected on newborns who are less than 10 days old. \.br\\.br\Biotinidase Deficiency: This screen for Biotinidase Deficiency was positive. Another specimen MUST be collected on this infant. \.br\\.br\If you have any questions regarding these screening outcomes, please contact the Newborn Screening Staff at at . \.br\\.br\Methods and Limitations:\.br\\.br\Assays for ALD Tier-1, BD, CAH, CF, GAL, MS/MS Acylcarnitine and Amino Acid Panels, PCH, hemoglobinopathies, and SCID were performed at the testing laboratory specified on the front of this report. Assays for ALD Tier-2, CAH Tier-2, Pompe Disease Tier-1, MPS I Tier-1, and SMA were developed and/or optimized by the Genetic Disease Laboratory (GDL), and performed at GDL. Performance characteristics of these assays are determined by GDL. The SMA assay is designed to identify 95% of SMA patients who have homozygous deletions of the SMN1 gene on chromosome 5q. These assays have not been cleared or approved by the U.S. Food and Drug Administration (FDA). The FDA has determined that such clearance or approval is not necessary. The assays are used for clinical purposes. They should not be regarded as investigational or for research. GDL is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA-88) to perform high complexity genetic disease screening. \.br\Attention Healthcare Provider:\.br\\.br\\.br\|||N|||F|||20240711034913 +OBX|7|TX|57129-9^Full newborn screening summary report for display or printing^LN|1||||N|||F|||20240711034913 +OBR|3|7241234515^FormNumber||57717-1^Newborn screen card data panel|||202407111346|||||||||^HUBBARD^EUSTRATIA||||||20240711034913|||F +OBX|1|ST|57716-3^State printed on filter paper card [Identifier] in NBS card^LN|1|CA|||N|||F|||20240711034913 +OBX|2|NM|8339-4^Birthweight^LN|1|3500|grams||N|||F|||20240711034913 +OBX|3|CE|57722-1^Birth plurality of Pregnancy^LN|1|LA12411-7^Singleton^LN|||N|||F|||20240711034913 +OBX|4|NM|73806-2^Newborn age in hours^LN|1|34|day(s)||N|||F|||20240711034913 +OBX|5|CE|57713-0^Infant NICU factors that affect newborn screening interpretation^LN|1|LA137-2^None^LN|||N|||F|||20240711034913 +OBX|6|CE|67704-7^Feeding types^LN|1|LA16914-6^Breast milk^LN|||N|||F|||20240711034913 +OBX|7|TX|^^^99717-5^Accession Number^L|1|193-08-269/21-2024-21|||N|||F|||20240711034913 +OBX|8|TX|62324-9^Post-discharge provider name^LN|1|EUSTRATIA HUBBARD|||N|||F|||20240711034913 +OBX|9|TX|62327-2^Post-discharge provider practice address^LN|1|N 054TS ARALC, TS102 E SAN DIEGO CA 99999-9999 USA|||N|||F|||20240711034913 +OBR|4|7241234515^FormNumber||57794-0^Newborn screening test results panel in Dried blood spot|||202407111346|||||||||^HUBBARD^EUSTRATIA||||||20240711034913|||F +OBR|5|7241234515^FormNumber||53261-4^Amino acid newborn screen panel|||202407111346|||||||||^HUBBARD^EUSTRATIA||||||20240711034913|||F +OBX|1|NM|47633-3^Glycine [Moles/volume] in Dried blood spot^LN|1|0.5|µmol/L||N|||F|||20240711034913 +OBX|2|NM|53150-9^Alanine+Beta Alanine+Sarcosine [Moles/volume] in Dried blood spot^LN|1|500|µmol/L|<1000|N|||F|||20240711034913 +OBX|3|NM|47799-2^Valine [Moles/volume] in Dried blood spot^LN|1|0.5|µmol/L||N|||F|||20240711034913 +OBX|4|NM|53151-7^Valine/Phenylalanine [Molar ratio] in Dried blood spot^LN|1|0.00645|{Ratio}|<4.3|N|||F|||20240711034913 +OBX|5|NM|53152-5^Alloisoleucine+Isoleucine+Leucine+Hydroxyproline^LN|1|125|µmol/L|<230|N|||F|||20240711034913 +OBX|6|NM|53154-1^Alloisoleucine+Isoleucine+Leucine+Hydroxyproline/Alanine [Molar ratio] in Dried blood spot^LN|1|0.65|{Ratio}|<1.35|N|||F|||20240711034913 +OBX|7|NM|29573-3^Phenylalanine [Moles/volume] in Dried blood spot^LN|1|77.5|µmol/L|<175|N|||F|||20240711034913 +OBX|8|NM|35572-7^Phenylalanine/Tyrosine [Molar ratio] in Dried blood spot^LN|1|0.75|{Ratio}|<2.6|N|||F|||20240711034913 +OBX|9|NM|35571-9^Tyrosine [Moles/volume] in Dried blood spot^LN|1|425|µmol/L|<680|N|||F|||20240711034913 +OBX|10|NM|53231-7^Succinylacetone [Moles/volume] in Dried blood spot^LN|1|2.25|µmol/L|<6.1|N|||F|||20240711034913 +OBX|11|NM|47700-0^Methionine [Moles/volume] in Dried blood spot^LN|1|27|µmol/L|6.3-100|N|||F|||20240711034913 +OBX|12|NM|42892-0^Citrulline [Moles/volume] in Dried blood spot^LN|1|16.25|µmol/L|5-49|N|||F|||20240711034913 +OBX|13|NM|54092-2^Citrulline/Arginine [Molar ratio] in Dried blood spot^LN|1|3|{Ratio}|<4.8|N|||F|||20240711034913 +OBX|14|NM|53155-8^Asparagine+Ornithine [Moles/volume] in Dried blood spot^LN|1|400|µmol/L|<800|N|||F|||20240711034913 +OBX|15|NM|75215-4^Ornithine/Citrulline [Molar ratio] in Dried blood spot^LN|1|0.5|{Ratio}||N|||F|||20240711034913 +OBX|16|NM|47562-4^Arginine [Moles/volume] in Dried blood spot^LN|1|25|µmol/L|<63|N|||F|||20240711034913 +OBX|17|NM|75214-7^Arginine/Ornithine [Molar ratio] in Dried blood spot^LN|1|0.7|{Ratio}|<1.9|N|||F|||20240711034913 +OBX|18|NM|47732-3^Proline [Moles/volume] in Dried blood spot^LN|1|750|µmol/L|<1500|N|||F|||20240711034913 +OBX|19|TX|57710-6^Amino acidemias newborn screening comment/discussion^LN|1|Negative|||N|||F|||20240711034913 +OBR|6|7241234515^FormNumber||58092-8^Acylcarnitine newborn screen panel|||202407111346|||||||||^HUBBARD^EUSTRATIA||||||20240711034913|||F +OBX|1|CE|58088-6^Acylcarnitine newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|2|TX|58093-6^Acylcarnitine newborn screening comment/discussion^LN|1|Negative|||N|||F|||20240711034913 +OBR|7|7241234515^FormNumber||57084-6^Fatty acid oxidation newborn screen panel|||202407111346|||||||||^HUBBARD^EUSTRATIA||||||20240711034913|||F +OBX|1|NM|38481-8^Carnitine.free (C0)^LN|1|33|µmol/L|6.4-125|N|||F|||20240711034913 +OBX|2|NM|53235-8^Carnitine.free (C0)/Palmitoylcarnitine (C16)+Stearoylcarnitine (C18)^LN|1|37.5|{Ratio}|<70|N|||F|||20240711034913 +OBX|3|NM|50157-7^Acetylcarnitine (C2)^LN|1|20.38|µmol/L|10-80|N|||F|||20240711034913 +OBX|4|NM|75212-1^Malonylcarnitine (C3-DC)/Decanoylcarnitine (C10) [Molar ratio] in Dried blood spot^LN|1|0.62500|{Ratio}|<7.6|N|||F|||20240711034913 +OBX|5|NM|45211-0^Hexanoylcarnitine (C6)^LN|1|0.48|µmol/L|<0.95|N|||F|||20240711034913 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transferase^LN|1|55.00|enzyme units|>50|N|||F|||20240711034913 +OBX|2|CE|46737-3^Galactosemias newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|3|TX|57704-9^Galactosemias newborn screening comment-discussion^LN|1|Negative|||N|||F|||20240711034913 +OBR|13|7241234515^FormNumber||54081-5^Hemoglobinopathies newborn screening panel|||202407111346|||||||||^HUBBARD^EUSTRATIA||||||20240711034913|||F +OBX|1|TX|54104-5^Hemoglobin pattern^LN|1|FA||||||F|||20240711034913 +OBX|2|TX|57703-1^Hemoglobin disorders newborn screening comment/discussion^LN|1|Usual hemoglobin pattern. These results assume no transfusion prior to testing and do not rule out the possibility of a thalassemia trait or rare hemoglobin variants.||||||F|||20240711034913 +OBR|14|7241234515^FormNumber||57087-9^Biotinidase newborn screening panel|||202407111346|||||||||^HUBBARD^EUSTRATIA||||||20240711034913|||F +OBX|1|NM|75217-0^Biotinidase [Enzymatic activity/volume] in Dried blood spot^LN|1|8.00|ERU|>10|L|||F|||20240711034913 +OBX|2|CE|46761-3^Biotinidase deficiency newborn screen interpretation^LN|1|LA18593-6^Out of range^LN|||A|||F|||20240711034913 +OBX|3|TX|57699-1^Biotinidase deficiency newborn screening comment-discussion^LN|1|Positive|||A|||F|||20240711034913 +OBR|15|7241234515^FormNumber||62333-0^Severe combined immunodeficiency (SCID) newborn screening panel|||202407111346|||||||||^HUBBARD^EUSTRATIA||||||20240711034913|||F +OBX|1|NM|62320-7^T-cell receptor excision circle [#/volume] in Dried blood spot by Probe and target amplification method^LN|1|33|copies/µL|>18|N|||F|||20240711034913 +OBX|2|CE|62321-5^Severe combined immunodeficiency newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|3|TX|62322-3^Severe combined immunodeficiency newborn screening comment-discussion^LN|1|Negative|||N|||F|||20240711034913 +OBR|16|7241234515^FormNumber||63414-7^Pompe Disease newborn screening panel|||202407111346|||||||||^HUBBARD^EUSTRATIA||||||20240711034913|||F +OBX|1|NM|55827-0^Acid alpha glucosidase [Enzymatic activity/volume] in DBS^LN|1|12.923|µmol/L/h|>=2.079|N|||F|||20240711034913 +OBX|2|CE|63415-4^Pompe Disease deficiency newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|3|TX|63416-2^Pompe Disease deficiency newborn screening comments-discussion^LN|1|Negative|||N|||F|||20240711034913 +OBR|17|7241234515^FormNumber||79563-3^Mucopolysaccharidosis type I newborn screening panel|||202407111346|||||||||^HUBBARD^EUSTRATIA||||||20240711034913|||F +OBX|1|NM|55909-6^Alpha-L-iduronidase [Enzymatic activity/volume] in DBS^LN|1|3.117|µmol/L/h|>=1.2204|N|||F|||20240711034913 +OBX|2|CE|79564-1^Mucopolysaccharidosis type I newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|3|TX|79565-8^Mucopolysaccharidosis type I newborn screening comment-discussion^LN|1|Negative|||N|||F|||20240711034913 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specimens collected on newborns who are less than 10 days old. \\.br\\\\.br\\Biotinidase Deficiency: This screen for Biotinidase Deficiency was positive. Another specimen MUST be collected on this infant. \\.br\\\\.br\\If you have any questions regarding these screening outcomes, please contact the Newborn Screening Staff at at . \\.br\\\\.br\\Methods and Limitations:\\.br\\\\.br\\Assays for ALD Tier-1, BD, CAH, CF, GAL, MS/MS Acylcarnitine and Amino Acid Panels, PCH, hemoglobinopathies, and SCID were performed at the testing laboratory specified on the front of this report. Assays for ALD Tier-2, CAH Tier-2, Pompe Disease Tier-1, MPS I Tier-1, and SMA were developed and/or optimized by the Genetic Disease Laboratory (GDL), and performed at GDL. Performance characteristics of these assays are determined by GDL. The SMA assay is designed to identify 95% of SMA patients who have homozygous deletions of the SMN1 gene on chromosome 5q. These assays have not been cleared or approved by the U.S. Food and Drug Administration (FDA). The FDA has determined that such clearance or approval is not necessary. The assays are used for clinical purposes. They should not be regarded as investigational or for research. 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screen^LN|||N|||F|||20240711034913 +OBX|2|CE|57718-9^Sample quality of Dried blood spot^LN|1|LA12432-3^Acceptable^LN|||N|||F|||20240711034913 +OBX|3|CE|57130-7^Newborn screening report - overall interpretation^LN|1|LA18944-1^Screen is out of range for at least one condition^LN|||N|||F|||20240711034913 +OBX|4|CE|57131-5^Newborn conditions with positive markers [Identifier] in Dried blood spot^LN|1|LA12532-0^BIO^LN|||N|||F|||20240711034913 +OBX|5|CE|57720-5^Newborn conditions with equivocal markers [Identifier] in Dried blood spot^LN|1|LA137-2^None^LN|||N|||F|||20240711034913 +OBX|6|TX|57724-7^Newborn screening short narrative summary^LN|1|ACTION REQUIRED\.br\\.br\NBS Testing Lab - COMMUNITY REG MEDICAL CENTER LAB \R\EG 4389EVA EESEN, TS054 E, FRESNO, CA 99999\.br\\.br\Genetic Disease Laboratory - GDL W 057DR HCLE, TS016 E, RICHMOND, CA 99999-9999\.br\\.br\Lab Director - Genetic Disease Laboratory, (510) 231-1790\.br\\.br\Duplicate\.br\\.br\Follow-up:\.br\\.br\Acyl Carnitine Panel: Reference Ranges for acylcarnitines are based on specimens collected on newborns who are less than 10 days old. \.br\\.br\Biotinidase Deficiency: This screen for Biotinidase Deficiency was positive. Another specimen MUST be collected on this infant. \.br\\.br\If you have any questions regarding these screening outcomes, please contact the Newborn Screening Staff at at . \.br\\.br\Methods and Limitations:\.br\\.br\Assays for ALD Tier-1, BD, CAH, CF, GAL, MS/MS Acylcarnitine and Amino Acid Panels, PCH, hemoglobinopathies, and SCID were performed at the testing laboratory specified on the front of this report. Assays for ALD Tier-2, CAH Tier-2, Pompe Disease Tier-1, MPS I Tier-1, and SMA were developed and/or optimized by the Genetic Disease Laboratory (GDL), and performed at GDL. Performance characteristics of these assays are determined by GDL. The SMA assay is designed to identify 95% of SMA patients who have homozygous deletions of the SMN1 gene on chromosome 5q. These assays have not been cleared or approved by the U.S. Food and Drug Administration (FDA). The FDA has determined that such clearance or approval is not necessary. The assays are used for clinical purposes. They should not be regarded as investigational or for research. GDL is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA-88) to perform high complexity genetic disease screening. \.br\Attention Healthcare Provider:\.br\\.br\\.br\|||N|||F|||20240711034913 +OBX|7|TX|57129-9^Full newborn screening summary report for display or printing^LN|1||||N|||F|||20240711034913 +OBX|8|ST|57716-3^State printed on filter paper card [Identifier] in NBS card^LN|1|CA|||N|||F|||20240711034913 +OBX|9|NM|8339-4^Birthweight^LN|1|3500|grams||N|||F|||20240711034913 +OBX|10|CE|57722-1^Birth plurality of Pregnancy^LN|1|LA12411-7^Singleton^LN|||N|||F|||20240711034913 +OBX|11|NM|73806-2^Newborn age in hours^LN|1|34|day(s)||N|||F|||20240711034913 +OBX|12|CE|57713-0^Infant NICU factors that affect newborn screening interpretation^LN|1|LA137-2^None^LN|||N|||F|||20240711034913 +OBX|13|CE|67704-7^Feeding types^LN|1|LA16914-6^Breast milk^LN|||N|||F|||20240711034913 +OBX|14|TX|^^^99717-5^Accession Number^L|1|193-08-269/21-2024-21|||N|||F|||20240711034913 +OBX|15|TX|62324-9^Post-discharge provider name^LN|1|EUSTRATIA HUBBARD|||N|||F|||20240711034913 +OBX|16|TX|62327-2^Post-discharge provider practice address^LN|1|N 054TS ARALC, TS102 E SAN DIEGO CA 99999-9999 USA|||N|||F|||20240711034913 +OBX|17|NM|47633-3^Glycine [Moles/volume] in Dried blood spot^LN|1|0.5|µmol/L||N|||F|||20240711034913 +OBX|18|NM|53150-9^Alanine+Beta Alanine+Sarcosine [Moles/volume] in Dried blood spot^LN|1|500|µmol/L|<1000|N|||F|||20240711034913 +OBX|19|NM|47799-2^Valine [Moles/volume] in Dried blood spot^LN|1|0.5|µmol/L||N|||F|||20240711034913 +OBX|20|NM|53151-7^Valine/Phenylalanine [Molar ratio] in Dried blood spot^LN|1|0.00645|{Ratio}|<4.3|N|||F|||20240711034913 +OBX|21|NM|53152-5^Alloisoleucine+Isoleucine+Leucine+Hydroxyproline^LN|1|125|µmol/L|<230|N|||F|||20240711034913 +OBX|22|NM|53154-1^Alloisoleucine+Isoleucine+Leucine+Hydroxyproline/Alanine [Molar ratio] in Dried blood spot^LN|1|0.65|{Ratio}|<1.35|N|||F|||20240711034913 +OBX|23|NM|29573-3^Phenylalanine [Moles/volume] in Dried blood spot^LN|1|77.5|µmol/L|<175|N|||F|||20240711034913 +OBX|24|NM|35572-7^Phenylalanine/Tyrosine [Molar ratio] in Dried blood spot^LN|1|0.75|{Ratio}|<2.6|N|||F|||20240711034913 +OBX|25|NM|35571-9^Tyrosine [Moles/volume] in Dried blood spot^LN|1|425|µmol/L|<680|N|||F|||20240711034913 +OBX|26|NM|53231-7^Succinylacetone [Moles/volume] in Dried blood spot^LN|1|2.25|µmol/L|<6.1|N|||F|||20240711034913 +OBX|27|NM|47700-0^Methionine [Moles/volume] in Dried blood spot^LN|1|27|µmol/L|6.3-100|N|||F|||20240711034913 +OBX|28|NM|42892-0^Citrulline [Moles/volume] in Dried blood spot^LN|1|16.25|µmol/L|5-49|N|||F|||20240711034913 +OBX|29|NM|54092-2^Citrulline/Arginine [Molar ratio] in Dried blood spot^LN|1|3|{Ratio}|<4.8|N|||F|||20240711034913 +OBX|30|NM|53155-8^Asparagine+Ornithine [Moles/volume] in Dried blood spot^LN|1|400|µmol/L|<800|N|||F|||20240711034913 +OBX|31|NM|75215-4^Ornithine/Citrulline [Molar ratio] in Dried blood spot^LN|1|0.5|{Ratio}||N|||F|||20240711034913 +OBX|32|NM|47562-4^Arginine [Moles/volume] in Dried blood spot^LN|1|25|µmol/L|<63|N|||F|||20240711034913 +OBX|33|NM|75214-7^Arginine/Ornithine [Molar ratio] in Dried blood spot^LN|1|0.7|{Ratio}|<1.9|N|||F|||20240711034913 +OBX|34|NM|47732-3^Proline [Moles/volume] in Dried blood spot^LN|1|750|µmol/L|<1500|N|||F|||20240711034913 +OBX|35|TX|57710-6^Amino acidemias newborn screening comment/discussion^LN|1|Negative|||N|||F|||20240711034913 +OBX|36|CE|58088-6^Acylcarnitine newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|37|TX|58093-6^Acylcarnitine newborn screening comment/discussion^LN|1|Negative|||N|||F|||20240711034913 +OBX|38|NM|38481-8^Carnitine.free (C0)^LN|1|33|µmol/L|6.4-125|N|||F|||20240711034913 +OBX|39|NM|53235-8^Carnitine.free (C0)/Palmitoylcarnitine (C16)+Stearoylcarnitine (C18)^LN|1|37.5|{Ratio}|<70|N|||F|||20240711034913 +OBX|40|NM|50157-7^Acetylcarnitine (C2)^LN|1|20.38|µmol/L|10-80|N|||F|||20240711034913 +OBX|41|NM|75212-1^Malonylcarnitine (C3-DC)/Decanoylcarnitine (C10) [Molar ratio] in Dried blood spot^LN|1|0.625|{Ratio}|<7.6|N|||F|||20240711034913 +OBX|42|NM|45211-0^Hexanoylcarnitine (C6)^LN|1|0.48|µmol/L|<0.95|N|||F|||20240711034913 +OBX|43|NM|53175-6^Octanoylcarnitine (C8)^LN|1|0.3|µmol/L|<0.45|N|||F|||20240711034913 +OBX|44|NM|53177-2^Octanoylcarnitine (C8)/Decanoylcarnitine (C10)^LN|1|0.5|{Ratio}||N|||F|||20240711034913 +OBX|45|NM|53174-9^Octenoylcarnitine (C8:1)^LN|1|0.35|µmol/L|<0.65|N|||F|||20240711034913 +OBX|46|NM|45197-1^Decanoylcarnitine (C10)^LN|1|0.32|µmol/L|<0.65|N|||F|||20240711034913 +OBX|47|NM|45198-9^Decenoylcarnitine (C10:1)^LN|1|0.22|µmol/L|<0.45|N|||F|||20240711034913 +OBX|48|NM|45199-7^Dodecanoylcarnitine (C12)^LN|1|1|µmol/L|<2|N|||F|||20240711034913 +OBX|49|NM|45200-3^Dodecenoylcarnitine (C12:1)^LN|1|0.5|µmol/L||N|||F|||20240711034913 +OBX|50|NM|53192-1^Tetradecanoylcarnitine (C14)^LN|1|0.6|µmol/L|<1.2|N|||F|||20240711034913 +OBX|51|NM|53191-3^Tetradecenoylcarnitine (C14:1)^LN|1|0.4|µmol/L|<0.9|N|||F|||20240711034913 +OBX|52|NM|53194-7^Tetradecenoylcarnitine (C14:1)/Dodecenoylcarnitine (C12:1)^LN|1|0.5|{Ratio}||N|||F|||20240711034913 +OBX|53|NM|53190-5^Tetradecadienoylcarnitine (C14:2)^LN|1|0.5|µmol/L||N|||F|||20240711034913 +OBX|54|NM|50281-5^3-Hydroxytetradecanoylcarnitine (C14-OH)^LN|1|0.1|µmol/L|<0.2|N|||F|||20240711034913 +OBX|55|NM|53199-6^Palmitoylcarnitine (C16)^LN|1|5|µmol/L|<12|N|||F|||20240711034913 +OBX|56|NM|53198-8^Palmitoleylcarnitine (C16:1)^LN|1|0.7|µmol/L|<1.4|N|||F|||20240711034913 +OBX|57|NM|50125-4^3-Hydroxypalmitoylcarnitine (C16-OH)^LN|1|0.05|µmol/L|<0.1|N|||F|||20240711034913 +OBX|58|NM|53201-0^3-Hydroxypalmitoylcarnitine (C16-OH)/Palmitoylcarnitine (C16)^LN|1|0.01|{Ratio}|<0.07|N|||F|||20240711034913 +OBX|59|NM|53241-6^Stearoylcarnitine (C18)^LN|1|2|µmol/L|<3.5|N|||F|||20240711034913 +OBX|60|NM|53202-8^Oleoylcarnitine (C18:1)^LN|1|3.5|µmol/L|<7|N|||F|||20240711034913 +OBX|61|NM|45217-7^Linoleoylcarnitine (C18:2)^LN|1|0.5|µmol/L||N|||F|||20240711034913 +OBX|62|NM|50132-0^3-Hydroxystearoylcarnitine (C18-OH)^LN|1|0.05|µmol/L|<0.1|N|||F|||20240711034913 +OBX|63|NM|50113-0^3-Hydroxyoleoylcarnitine (C18:1-OH)^LN|1|0.05|µmol/L|<0.1|N|||F|||20240711034913 +OBX|64|NM|53160-8^Propionylcarnitine (C3)^LN|1|3.15|µmol/L|<7.9|N|||F|||20240711034913 +OBX|65|NM|53163-2^Propionylcarnitine (C3)/Acetylcarnitine (C2)^LN|1|0.15|{Ratio}|<0.42|N|||F|||20240711034913 +OBX|66|NM|67708-8^Malonylcarnitine (C3-DC)+3-Hydroxybutyrylcarnitine (C4-OH)^LN|1|0.2|µmol/L|<0.48|N|||F|||20240711034913 +OBX|67|NM|53166-5^Butyrylcarnitine+Isobutyrylcarnitine (C4)^LN|1|0.85|µmol/L|<1.7|N|||F|||20240711034913 +OBX|68|NM|45216-9^Isovalerylcarnitine+Methylbutyrylcarnitine (C5)^LN|1|0.5|µmol/L|<0.95|N|||F|||20240711034913 +OBX|69|NM|53240-8^Isovalerylcarnitine+Methylbutyrylcarnitine (C5)/Propionylcarnitine (C3)^LN|1|0.15873|{Ratio}|<0.38|N|||F|||20240711034913 +OBX|70|NM|53170-7^Tiglylcarnitine (C5:1)^LN|1|0.3|µmol/L|<0.5|N|||F|||20240711034913 +OBX|71|NM|50106-4^3-Hydroxyisovalerylcarnitine (C5-OH)^LN|1|0.45|µmol/L|<1.15|N|||F|||20240711034913 +OBX|72|NM|67710-4^Glutarylcarnitine (C5-DC)+3-Hydroxyhexanoylcarnitine (C6-OH)^LN|1|0.3|µmol/L|<0.38|N|||F|||20240711034913 +OBX|73|NM|75216-2^Glutarylcarnitine (C5-DC)/Malonylcarnitine (C3-DC) [Molar ratio] in Dried blood spot^LN|1|1.5|{Ratio}|>0.1|N|||F|||20240711034913 +OBX|74|NM|48633-2^Trypsinogen I.free^LN|1|31.0|ng/mL|<69|N|||F|||20240711034913 +OBX|75|CE|46769-6^Cystic fibrosis newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|76|TX|57707-2^Cystic fibrosis newborn screening comment/discussion^LN|1|Negative|||N|||F|||20240711034913 +OBX|77|NM|38473-5^17-Hydroxyprogesterone^LN|1|35|nmol/L|<85|N|||F|||20240711034913 +OBX|78|CE|46758-9^Congenital adrenal hyperplasia newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|79|TX|57706-4^Congenital adrenal hyperplasia newborn screening comment-discussion^LN|1|Negative|||N|||F|||20240711034913 +OBX|80|NM|29575-8^Thyrotropin^LN|1|14.5|mIU/L|<29|N|||F|||20240711034913 +OBX|81|CE|46762-1^Congenital hypothyroidism newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|82|TX|57705-6^Congenital hypothyroidism newborn screening comment-discussion^LN|1|Negative|||N|||F|||20240711034913 +OBX|83|NM|42906-8^Galactose 1 phosphate uridyl transferase^LN|1|55.0|enzyme units|>50|N|||F|||20240711034913 +OBX|84|CE|46737-3^Galactosemias newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|85|TX|57704-9^Galactosemias newborn screening comment-discussion^LN|1|Negative|||N|||F|||20240711034913 +OBX|86|TX|54104-5^Hemoglobin pattern^LN|1|FA||||||F|||20240711034913 +OBX|87|TX|57703-1^Hemoglobin disorders newborn screening comment/discussion^LN|1|Usual hemoglobin pattern. These results assume no transfusion prior to testing and do not rule out the possibility of a thalassemia trait or rare hemoglobin variants.||||||F|||20240711034913 +OBX|88|NM|75217-0^Biotinidase [Enzymatic activity/volume] in Dried blood spot^LN|1|8.0|ERU|>10|L|||F|||20240711034913 +OBX|89|CE|46761-3^Biotinidase deficiency newborn screen interpretation^LN|1|LA18593-6^Out of range^LN|||A|||F|||20240711034913 +OBX|90|TX|57699-1^Biotinidase deficiency newborn screening comment-discussion^LN|1|Positive|||A|||F|||20240711034913 +OBX|91|NM|62320-7^T-cell receptor excision circle [#/volume] in Dried blood spot by Probe and target amplification method^LN|1|33|copies/µL|>18|N|||F|||20240711034913 +OBX|92|CE|62321-5^Severe combined immunodeficiency newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|93|TX|62322-3^Severe combined immunodeficiency newborn screening comment-discussion^LN|1|Negative|||N|||F|||20240711034913 +OBX|94|NM|55827-0^Acid alpha glucosidase [Enzymatic activity/volume] in DBS^LN|1|12.923|µmol/L/h|>=2.079|N|||F|||20240711034913 +OBX|95|CE|63415-4^Pompe Disease deficiency newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|96|TX|63416-2^Pompe Disease deficiency newborn screening comments-discussion^LN|1|Negative|||N|||F|||20240711034913 +OBX|97|NM|55909-6^Alpha-L-iduronidase [Enzymatic activity/volume] in DBS^LN|1|3.117|µmol/L/h|>=1.2204|N|||F|||20240711034913 +OBX|98|CE|79564-1^Mucopolysaccharidosis type I newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|99|TX|79565-8^Mucopolysaccharidosis type I newborn screening comment-discussion^LN|1|Negative|||N|||F|||20240711034913 +OBX|100|TX|^^^99717-60^SMN1 Homozygous Deletion Analysis^L|1|Exon 7 Present||Exon 7 Present|N|||F|||20240711034913 +OBX|101|CE|92004-1^Spinal muscular atrophy newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|102|TX|92003-3^Spinal muscular atrophy newborn screening comment-discussion^LN|1|SMA Negative|||N|||F|||20240711034913 +OBX|103|CE|^^^99717-32^Adrenoleukodystrophy deficiency newborn screening interpretation^L|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|104|TX|^^^99717-33^Adrenoleukodystrophy deficiency newborn screening comments-discussion^L|1|Negative|||N|||F|||20240711034913 +OBX|105|NM|79321-6^Lysophosphatidylcholine(26:0) [Moles/volume] in Dried blood spot^LN|1|0.2|µmol/L|<0.47|N|||F|||20240711034913 diff --git a/examples/CA/019_CA_ORU_R01_CDPH_empty_orc12_obr16_UCSD2024-07-11-16-02-17-749_0_initial_message.hl7 b/examples/CA/019_CA_ORU_R01_CDPH_empty_orc12_obr16_UCSD2024-07-11-16-02-17-749_0_initial_message.hl7 new file mode 100644 index 000000000..86ad6a2b7 --- /dev/null +++ b/examples/CA/019_CA_ORU_R01_CDPH_empty_orc12_obr16_UCSD2024-07-11-16-02-17-749_0_initial_message.hl7 @@ -0,0 +1,129 @@ +MSH|^~\&|SISGDSP|SISGDSP|SISHIERECEIVER^11903029^L,M,N|^^L,M,N|20240711034913||ORU^R01^ORU_R01|243747623|T|2.5.1 +PID|1||80009197^^^&NPI^MR||NICUABG^TESTONE^^^^^B||20240607|M||2076-8^Native Hawaiian or Other Pacific Islander||||||||||||2186-5^Not Hispanic or Latino||N|1 +NK1|1|NICUABG|MTH^Mother +ORC|RE|7241234515^FormNumber||189609160^HospOrdNumber|||||||||||||||||^^^^^^^^^R797| N 054TS ARALC, TS102 E^^SAN DIEGO^CA^99999-9999 +OBR|1|7241234515^FormNumber||54089-8^NB Screen Panel Patient AHIC|||202407111346|||||||||||||||20240711034913|||F +OBR|2|7241234515^FormNumber||57128-1^Newborn Screening Report summary panel|||202407111346|||||||||||||||20240711034913|||F +OBX|1|CE|57721-3^Reason for lab test in Dried blood spot^LN|1|LA12421-6^Initial screen^LN|||N|||F|||20240711034913 +OBX|2|CE|57718-9^Sample quality of Dried blood spot^LN|1|LA12432-3^Acceptable^LN|||N|||F|||20240711034913 +OBX|3|CE|57130-7^Newborn screening report - overall interpretation^LN|1|LA18944-1^Screen is out of range for at least one condition^LN|||N|||F|||20240711034913 +OBX|4|CE|57131-5^Newborn conditions with positive markers [Identifier] in Dried blood spot^LN|1|LA12532-0^BIO^LN|||N|||F|||20240711034913 +OBX|5|CE|57720-5^Newborn conditions with equivocal markers [Identifier] in Dried blood spot^LN|1|LA137-2^None^LN|||N|||F|||20240711034913 +OBX|6|TX|57724-7^Newborn screening short narrative summary^LN|1|ACTION REQUIRED\.br\\.br\NBS Testing Lab - COMMUNITY REG MEDICAL CENTER LAB \R\EG 4389EVA EESEN, TS054 E, FRESNO, CA 99999\.br\\.br\Genetic Disease Laboratory - GDL W 057DR HCLE, TS016 E, RICHMOND, CA 99999-9999\.br\\.br\Lab Director - Genetic Disease Laboratory, (510) 231-1790\.br\\.br\Duplicate\.br\\.br\Follow-up:\.br\\.br\Acyl Carnitine Panel: Reference Ranges for acylcarnitines are based on specimens collected on newborns who are less than 10 days old. \.br\\.br\Biotinidase Deficiency: This screen for Biotinidase Deficiency was positive. Another specimen MUST be collected on this infant. \.br\\.br\If you have any questions regarding these screening outcomes, please contact the Newborn Screening Staff at at . \.br\\.br\Methods and Limitations:\.br\\.br\Assays for ALD Tier-1, BD, CAH, CF, GAL, MS/MS Acylcarnitine and Amino Acid Panels, PCH, hemoglobinopathies, and SCID were performed at the testing laboratory specified on the front of this report. Assays for ALD Tier-2, CAH Tier-2, Pompe Disease Tier-1, MPS I Tier-1, and SMA were developed and/or optimized by the Genetic Disease Laboratory (GDL), and performed at GDL. Performance characteristics of these assays are determined by GDL. The SMA assay is designed to identify 95% of SMA patients who have homozygous deletions of the SMN1 gene on chromosome 5q. These assays have not been cleared or approved by the U.S. Food and Drug Administration (FDA). The FDA has determined that such clearance or approval is not necessary. The assays are used for clinical purposes. They should not be regarded as investigational or for research. GDL is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA-88) to perform high complexity genetic disease screening. \.br\Attention Healthcare Provider:\.br\\.br\\.br\|||N|||F|||20240711034913 +OBX|7|TX|57129-9^Full newborn screening summary report for display or printing^LN|1||||N|||F|||20240711034913 +OBR|3|7241234515^FormNumber||57717-1^Newborn screen card data panel|||202407111346|||||||||||||||20240711034913|||F +OBX|1|ST|57716-3^State printed on filter paper card [Identifier] in NBS card^LN|1|CA|||N|||F|||20240711034913 +OBX|2|NM|8339-4^Birthweight^LN|1|3500|grams||N|||F|||20240711034913 +OBX|3|CE|57722-1^Birth plurality of Pregnancy^LN|1|LA12411-7^Singleton^LN|||N|||F|||20240711034913 +OBX|4|NM|73806-2^Newborn age in hours^LN|1|34|day(s)||N|||F|||20240711034913 +OBX|5|CE|57713-0^Infant NICU factors that affect newborn screening interpretation^LN|1|LA137-2^None^LN|||N|||F|||20240711034913 +OBX|6|CE|67704-7^Feeding types^LN|1|LA16914-6^Breast milk^LN|||N|||F|||20240711034913 +OBX|7|TX|^^^99717-5^Accession Number^L|1|193-08-269/21-2024-21|||N|||F|||20240711034913 +OBX|8|TX|62324-9^Post-discharge provider name^LN|1|EUSTRATIA HUBBARD|||N|||F|||20240711034913 +OBX|9|TX|62327-2^Post-discharge provider practice address^LN|1|N 054TS ARALC, TS102 E SAN DIEGO CA 99999-9999 USA|||N|||F|||20240711034913 +OBR|4|7241234515^FormNumber||57794-0^Newborn screening test results panel in Dried blood spot|||202407111346|||||||||||||||20240711034913|||F +OBR|5|7241234515^FormNumber||53261-4^Amino acid newborn screen panel|||202407111346|||||||||||||||20240711034913|||F +OBX|1|NM|47633-3^Glycine [Moles/volume] in Dried blood spot^LN|1|0.5|µmol/L||N|||F|||20240711034913 +OBX|2|NM|53150-9^Alanine+Beta Alanine+Sarcosine [Moles/volume] in Dried blood spot^LN|1|500|µmol/L|<1000|N|||F|||20240711034913 +OBX|3|NM|47799-2^Valine [Moles/volume] in Dried blood spot^LN|1|0.5|µmol/L||N|||F|||20240711034913 +OBX|4|NM|53151-7^Valine/Phenylalanine [Molar ratio] in Dried blood spot^LN|1|0.00645|{Ratio}|<4.3|N|||F|||20240711034913 +OBX|5|NM|53152-5^Alloisoleucine+Isoleucine+Leucine+Hydroxyproline^LN|1|125|µmol/L|<230|N|||F|||20240711034913 +OBX|6|NM|53154-1^Alloisoleucine+Isoleucine+Leucine+Hydroxyproline/Alanine [Molar ratio] in Dried blood spot^LN|1|0.65|{Ratio}|<1.35|N|||F|||20240711034913 +OBX|7|NM|29573-3^Phenylalanine [Moles/volume] in Dried blood spot^LN|1|77.5|µmol/L|<175|N|||F|||20240711034913 +OBX|8|NM|35572-7^Phenylalanine/Tyrosine [Molar ratio] in Dried blood spot^LN|1|0.75|{Ratio}|<2.6|N|||F|||20240711034913 +OBX|9|NM|35571-9^Tyrosine [Moles/volume] in Dried blood spot^LN|1|425|µmol/L|<680|N|||F|||20240711034913 +OBX|10|NM|53231-7^Succinylacetone [Moles/volume] in Dried blood spot^LN|1|2.25|µmol/L|<6.1|N|||F|||20240711034913 +OBX|11|NM|47700-0^Methionine [Moles/volume] in Dried blood spot^LN|1|27|µmol/L|6.3-100|N|||F|||20240711034913 +OBX|12|NM|42892-0^Citrulline [Moles/volume] in Dried blood spot^LN|1|16.25|µmol/L|5-49|N|||F|||20240711034913 +OBX|13|NM|54092-2^Citrulline/Arginine [Molar ratio] in Dried blood spot^LN|1|3|{Ratio}|<4.8|N|||F|||20240711034913 +OBX|14|NM|53155-8^Asparagine+Ornithine [Moles/volume] in Dried blood spot^LN|1|400|µmol/L|<800|N|||F|||20240711034913 +OBX|15|NM|75215-4^Ornithine/Citrulline [Molar ratio] in Dried blood spot^LN|1|0.5|{Ratio}||N|||F|||20240711034913 +OBX|16|NM|47562-4^Arginine [Moles/volume] in Dried blood spot^LN|1|25|µmol/L|<63|N|||F|||20240711034913 +OBX|17|NM|75214-7^Arginine/Ornithine [Molar ratio] in Dried blood spot^LN|1|0.7|{Ratio}|<1.9|N|||F|||20240711034913 +OBX|18|NM|47732-3^Proline [Moles/volume] in Dried blood spot^LN|1|750|µmol/L|<1500|N|||F|||20240711034913 +OBX|19|TX|57710-6^Amino acidemias newborn screening comment/discussion^LN|1|Negative|||N|||F|||20240711034913 +OBR|6|7241234515^FormNumber||58092-8^Acylcarnitine newborn screen panel|||202407111346|||||||||||||||20240711034913|||F +OBX|1|CE|58088-6^Acylcarnitine newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|2|TX|58093-6^Acylcarnitine newborn screening comment/discussion^LN|1|Negative|||N|||F|||20240711034913 +OBR|7|7241234515^FormNumber||57084-6^Fatty acid oxidation newborn screen panel|||202407111346|||||||||||||||20240711034913|||F +OBX|1|NM|38481-8^Carnitine.free (C0)^LN|1|33|µmol/L|6.4-125|N|||F|||20240711034913 +OBX|2|NM|53235-8^Carnitine.free (C0)/Palmitoylcarnitine (C16)+Stearoylcarnitine (C18)^LN|1|37.5|{Ratio}|<70|N|||F|||20240711034913 +OBX|3|NM|50157-7^Acetylcarnitine (C2)^LN|1|20.38|µmol/L|10-80|N|||F|||20240711034913 +OBX|4|NM|75212-1^Malonylcarnitine (C3-DC)/Decanoylcarnitine (C10) [Molar ratio] in Dried blood spot^LN|1|0.62500|{Ratio}|<7.6|N|||F|||20240711034913 +OBX|5|NM|45211-0^Hexanoylcarnitine (C6)^LN|1|0.48|µmol/L|<0.95|N|||F|||20240711034913 +OBX|6|NM|53175-6^Octanoylcarnitine (C8)^LN|1|0.3|µmol/L|<0.45|N|||F|||20240711034913 +OBX|7|NM|53177-2^Octanoylcarnitine (C8)/Decanoylcarnitine (C10)^LN|1|0.5|{Ratio}||N|||F|||20240711034913 +OBX|8|NM|53174-9^Octenoylcarnitine (C8:1)^LN|1|0.35|µmol/L|<0.65|N|||F|||20240711034913 +OBX|9|NM|45197-1^Decanoylcarnitine (C10)^LN|1|0.32|µmol/L|<0.65|N|||F|||20240711034913 +OBX|10|NM|45198-9^Decenoylcarnitine (C10:1)^LN|1|0.22|µmol/L|<0.45|N|||F|||20240711034913 +OBX|11|NM|45199-7^Dodecanoylcarnitine (C12)^LN|1|1|µmol/L|<2|N|||F|||20240711034913 +OBX|12|NM|45200-3^Dodecenoylcarnitine (C12:1)^LN|1|0.5|µmol/L||N|||F|||20240711034913 +OBX|13|NM|53192-1^Tetradecanoylcarnitine (C14)^LN|1|0.6|µmol/L|<1.2|N|||F|||20240711034913 +OBX|14|NM|53191-3^Tetradecenoylcarnitine (C14:1)^LN|1|0.4|µmol/L|<0.9|N|||F|||20240711034913 +OBX|15|NM|53194-7^Tetradecenoylcarnitine (C14:1)/Dodecenoylcarnitine (C12:1)^LN|1|0.5|{Ratio}||N|||F|||20240711034913 +OBX|16|NM|53190-5^Tetradecadienoylcarnitine (C14:2)^LN|1|0.5|µmol/L||N|||F|||20240711034913 +OBX|17|NM|50281-5^3-Hydroxytetradecanoylcarnitine (C14-OH)^LN|1|0.1|µmol/L|<0.2|N|||F|||20240711034913 +OBX|18|NM|53199-6^Palmitoylcarnitine (C16)^LN|1|5|µmol/L|<12|N|||F|||20240711034913 +OBX|19|NM|53198-8^Palmitoleylcarnitine (C16:1)^LN|1|0.7|µmol/L|<1.4|N|||F|||20240711034913 +OBX|20|NM|50125-4^3-Hydroxypalmitoylcarnitine (C16-OH)^LN|1|0.05|µmol/L|<0.1|N|||F|||20240711034913 +OBX|21|NM|53201-0^3-Hydroxypalmitoylcarnitine (C16-OH)/Palmitoylcarnitine (C16)^LN|1|0.01000|{Ratio}|<0.07|N|||F|||20240711034913 +OBX|22|NM|53241-6^Stearoylcarnitine (C18)^LN|1|2|µmol/L|<3.5|N|||F|||20240711034913 +OBX|23|NM|53202-8^Oleoylcarnitine (C18:1)^LN|1|3.5|µmol/L|<7|N|||F|||20240711034913 +OBX|24|NM|45217-7^Linoleoylcarnitine (C18:2)^LN|1|0.5|µmol/L||N|||F|||20240711034913 +OBX|25|NM|50132-0^3-Hydroxystearoylcarnitine (C18-OH)^LN|1|0.05|µmol/L|<0.1|N|||F|||20240711034913 +OBX|26|NM|50113-0^3-Hydroxyoleoylcarnitine (C18:1-OH)^LN|1|0.05|µmol/L|<0.1|N|||F|||20240711034913 +OBR|8|7241234515^FormNumber||57085-3^Organic acid newborn screen panel|||202407111346|||||||||||||||20240711034913|||F +OBX|1|NM|53160-8^Propionylcarnitine (C3)^LN|1|3.15|µmol/L|<7.9|N|||F|||20240711034913 +OBX|2|NM|53163-2^Propionylcarnitine (C3)/Acetylcarnitine (C2)^LN|1|0.15|{Ratio}|<0.42|N|||F|||20240711034913 +OBX|3|NM|67708-8^Malonylcarnitine (C3-DC)+3-Hydroxybutyrylcarnitine (C4-OH)^LN|1|0.2|µmol/L|<0.48|N|||F|||20240711034913 +OBX|4|NM|53166-5^Butyrylcarnitine+Isobutyrylcarnitine (C4)^LN|1|0.85|µmol/L|<1.7|N|||F|||20240711034913 +OBX|5|NM|45216-9^Isovalerylcarnitine+Methylbutyrylcarnitine (C5)^LN|1|0.5|µmol/L|<0.95|N|||F|||20240711034913 +OBX|6|NM|53240-8^Isovalerylcarnitine+Methylbutyrylcarnitine (C5)/Propionylcarnitine (C3)^LN|1|0.15873|{Ratio}|<0.38|N|||F|||20240711034913 +OBX|7|NM|53170-7^Tiglylcarnitine (C5:1)^LN|1|0.3|µmol/L|<0.5|N|||F|||20240711034913 +OBX|8|NM|50106-4^3-Hydroxyisovalerylcarnitine (C5-OH)^LN|1|0.45|µmol/L|<1.15|N|||F|||20240711034913 +OBX|9|NM|67710-4^Glutarylcarnitine (C5-DC)+3-Hydroxyhexanoylcarnitine (C6-OH)^LN|1|0.3|µmol/L|<0.38|N|||F|||20240711034913 +OBX|10|NM|75216-2^Glutarylcarnitine (C5-DC)/Malonylcarnitine (C3-DC) [Molar ratio] in Dried blood spot^LN|1|1.50000|{Ratio}|>0.1|N|||F|||20240711034913 +OBR|9|7241234515^FormNumber||54078-1^Cystic fibrosis newborn screening panel|||202407111346|||||||||||||||20240711034913|||F +OBX|1|NM|48633-2^Trypsinogen I.free^LN|1|31.00|ng/mL|<69|N|||F|||20240711034913 +OBX|2|CE|46769-6^Cystic fibrosis newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|3|TX|57707-2^Cystic fibrosis newborn screening comment/discussion^LN|1|Negative|||N|||F|||20240711034913 +OBR|10|7241234515^FormNumber||57086-1^Congenital adrenal hyperplasia newborn screening panel|||202407111346|||||||||||||||20240711034913|||F +OBX|1|NM|38473-5^17-Hydroxyprogesterone^LN|1|35|nmol/L|<85|N|||F|||20240711034913 +OBX|2|CE|46758-9^Congenital adrenal hyperplasia newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|3|TX|57706-4^Congenital adrenal hyperplasia newborn screening comment-discussion^LN|1|Negative|||N|||F|||20240711034913 +OBR|11|7241234515^FormNumber||54090-6^Thyroid newborn screening panel|||202407111346|||||||||||||||20240711034913|||F +OBX|1|NM|29575-8^Thyrotropin^LN|1|14.50|mIU/L|<29|N|||F|||20240711034913 +OBX|2|CE|46762-1^Congenital hypothyroidism newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|3|TX|57705-6^Congenital hypothyroidism newborn screening comment-discussion^LN|1|Negative|||N|||F|||20240711034913 +OBR|12|7241234515^FormNumber||54079-9^Galactosemia newborn screening panel|||202407111346|||||||||||||||20240711034913|||F +OBX|1|NM|42906-8^Galactose 1 phosphate uridyl transferase^LN|1|55.00|enzyme units|>50|N|||F|||20240711034913 +OBX|2|CE|46737-3^Galactosemias newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|3|TX|57704-9^Galactosemias newborn screening comment-discussion^LN|1|Negative|||N|||F|||20240711034913 +OBR|13|7241234515^FormNumber||54081-5^Hemoglobinopathies newborn screening panel|||202407111346|||||||||||||||20240711034913|||F +OBX|1|TX|54104-5^Hemoglobin pattern^LN|1|FA||||||F|||20240711034913 +OBX|2|TX|57703-1^Hemoglobin disorders newborn screening comment/discussion^LN|1|Usual hemoglobin pattern. These results assume no transfusion prior to testing and do not rule out the possibility of a thalassemia trait or rare hemoglobin variants.||||||F|||20240711034913 +OBR|14|7241234515^FormNumber||57087-9^Biotinidase newborn screening panel|||202407111346|||||||||||||||20240711034913|||F +OBX|1|NM|75217-0^Biotinidase [Enzymatic activity/volume] in Dried blood spot^LN|1|8.00|ERU|>10|L|||F|||20240711034913 +OBX|2|CE|46761-3^Biotinidase deficiency newborn screen interpretation^LN|1|LA18593-6^Out of range^LN|||A|||F|||20240711034913 +OBX|3|TX|57699-1^Biotinidase deficiency newborn screening comment-discussion^LN|1|Positive|||A|||F|||20240711034913 +OBR|15|7241234515^FormNumber||62333-0^Severe combined immunodeficiency (SCID) newborn screening panel|||202407111346|||||||||||||||20240711034913|||F +OBX|1|NM|62320-7^T-cell receptor excision circle [#/volume] in Dried blood spot by Probe and target amplification method^LN|1|33|copies/µL|>18|N|||F|||20240711034913 +OBX|2|CE|62321-5^Severe combined immunodeficiency newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|3|TX|62322-3^Severe combined immunodeficiency newborn screening comment-discussion^LN|1|Negative|||N|||F|||20240711034913 +OBR|16|7241234515^FormNumber||63414-7^Pompe Disease newborn screening panel|||202407111346|||||||||||||||20240711034913|||F +OBX|1|NM|55827-0^Acid alpha glucosidase [Enzymatic activity/volume] in DBS^LN|1|12.923|µmol/L/h|>=2.079|N|||F|||20240711034913 +OBX|2|CE|63415-4^Pompe Disease deficiency newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|3|TX|63416-2^Pompe Disease deficiency newborn screening comments-discussion^LN|1|Negative|||N|||F|||20240711034913 +OBR|17|7241234515^FormNumber||79563-3^Mucopolysaccharidosis type I newborn screening panel|||202407111346|||||||||||||||20240711034913|||F +OBX|1|NM|55909-6^Alpha-L-iduronidase [Enzymatic activity/volume] in DBS^LN|1|3.117|µmol/L/h|>=1.2204|N|||F|||20240711034913 +OBX|2|CE|79564-1^Mucopolysaccharidosis type I newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|3|TX|79565-8^Mucopolysaccharidosis type I newborn screening comment-discussion^LN|1|Negative|||N|||F|||20240711034913 +OBR|18|7241234515^FormNumber||92005-8^Spinal muscular atrophy newborn screening panel|||202407111346|||||||||||||||20240711034913|||F +OBX|1|TX|^^^99717-60^SMN1 Homozygous Deletion Analysis^L|1|Exon 7 Present||Exon 7 Present|N|||F|||20240711034913 +OBX|2|CE|92004-1^Spinal muscular atrophy newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|3|TX|92003-3^Spinal muscular atrophy newborn screening comment-discussion^LN|1|SMA Negative|||N|||F|||20240711034913 +OBR|19|7241234515^FormNumber||^^^99717-28^Adrenoleukodystrophy newborn screening panel^L|||202407111346|||||||||||||||20240711034913|||F +OBX|1|CE|^^^99717-32^Adrenoleukodystrophy deficiency newborn screening interpretation^L|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|2|TX|^^^99717-33^Adrenoleukodystrophy deficiency newborn screening comments-discussion^L|1|Negative|||N|||F|||20240711034913 +OBR|20|7241234515^FormNumber||^^^99717-29^Adrenoleukodystrophy Tier-1 newborn screening panel^L|||202407111346|||||||||||||||20240711034913|||F +OBX|1|NM|79321-6^Lysophosphatidylcholine(26:0) [Moles/volume] in Dried blood spot^LN|1|0.2|µmol/L|<0.47|N|||F|||20240711034913 diff --git a/examples/CA/019_CA_ORU_R01_CDPH_empty_orc12_obr16_UCSD2024-07-11-16-02-17-749_1_hl7_translation.fhir b/examples/CA/019_CA_ORU_R01_CDPH_empty_orc12_obr16_UCSD2024-07-11-16-02-17-749_1_hl7_translation.fhir new file mode 100644 index 000000000..de947dcc8 --- /dev/null +++ b/examples/CA/019_CA_ORU_R01_CDPH_empty_orc12_obr16_UCSD2024-07-11-16-02-17-749_1_hl7_translation.fhir @@ -0,0 +1,14005 @@ +{ + "resourceType": "Bundle", + "id": "1724947358218980181.1ad3d524-82af-4751-89ab-8a1550ba6189", + "meta": { + "lastUpdated": "2024-08-29T16:02:38.219+00:00" + }, + "identifier": { + "system": "https://reportstream.cdc.gov/prime-router", + "value": "243747623" + }, + "type": "message", + "timestamp": "2024-07-11T03:49:13.000+00:00", + "entry": [ + { + "fullUrl": "MessageHeader/1724947358219935951.4fa82f5e-3a0d-4dd3-af43-86ee292e8442", + "resource": { + "resourceType": "MessageHeader", + "id": "1724947358219935951.4fa82f5e-3a0d-4dd3-af43-86ee292e8442", + "meta": { + "tag": [ + { + "system": "http://terminology.hl7.org/CodeSystem/v2-0103", + "code": "T" + } + ] + }, + "extension": [ + { + "url": "https://reportstream.cdc.gov/fhir/StructureDefinition/msh-message-header", + "extension": [ + { + "url": "MSH.7", + "valueString": "20240711034913" + } + ] + } + ], + "eventCoding": { + "system": "http://terminology.hl7.org/CodeSystem/v2-0003", + "code": "R01", + "display": "ORU^R01^ORU_R01" + }, + "destination": [ + { + "extension": [ + { + "url": "https://reportstream.cdc.gov/fhir/StructureDefinition/universal-id", + "valueString": "11903029" + }, + { + "url": "https://reportstream.cdc.gov/fhir/StructureDefinition/universal-id-type", + "valueString": "L,M,N" + }, + { + "url": "https://reportstream.cdc.gov/fhir/StructureDefinition/hl7v2Field", + "valueString": "MSH.5" + } + ], + "name": "SISHIERECEIVER", + "receiver": { + "reference": "Organization/1724947358219789755.580678c9-a01e-4ece-b28d-0924a24b4230" + } + } + ], + "sender": { + "reference": "Organization/1724947358219318486.fb3df7d2-49e0-435c-b255-d108eafd4989" + }, + "source": { + "extension": [ + { + "url": 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b/examples/CA/019_CA_ORU_R01_CDPH_empty_orc12_obr16_UCSD2024-07-11-16-02-17-749_3_hl7_translation_final.hl7 @@ -0,0 +1,110 @@ +MSH|^~\&|SISGDSP|CDPH|EPIC|R797|20240711034913||ORU^R01|243747623|T|2.5.1 +PID|1||80009197||NICUABG^TESTONE||20240607|M||2076-8^Native Hawaiian or Other Pacific Islander||||||||||||2186-5^Not Hispanic or Latino||N|1 +NK1|1|NICUABG|MTH^Mother +ORC|RE|189609160^HospOrdNumber||7241234515^FormNumber|||||||||||||||||^^^^^^^^^R797|N 054TS ARALC, TS102 E^^SAN DIEGO^CA^99999-9999 +OBR|1|189609160^HospOrdNumber||54089-8^NB Screen Panel Patient AHIC^LN^CDPHGSPEAP|||202407111346|||||||||||||||20240711034913|||F +OBX|1|CE|57721-3^Reason for lab test in Dried blood spot^LN|1|LA12421-6^Initial screen^LN|||N|||F|||20240711034913 +OBX|2|CE|57718-9^Sample quality of Dried blood spot^LN|1|LA12432-3^Acceptable^LN|||N|||F|||20240711034913 +OBX|3|CE|57130-7^Newborn screening report - overall interpretation^LN|1|LA18944-1^Screen is out of range for at least one condition^LN|||N|||F|||20240711034913 +OBX|4|CE|57131-5^Newborn conditions with positive markers [Identifier] in Dried blood spot^LN|1|LA12532-0^BIO^LN|||N|||F|||20240711034913 +OBX|5|CE|57720-5^Newborn conditions with equivocal markers [Identifier] in Dried blood spot^LN|1|LA137-2^None^LN|||N|||F|||20240711034913 +OBX|6|TX|57724-7^Newborn screening short narrative summary^LN|1|ACTION REQUIRED\.br\\.br\NBS Testing Lab - COMMUNITY REG MEDICAL CENTER LAB \R\EG 4389EVA EESEN, TS054 E, FRESNO, CA 99999\.br\\.br\Genetic Disease Laboratory - GDL W 057DR HCLE, TS016 E, RICHMOND, CA 99999-9999\.br\\.br\Lab Director - Genetic Disease Laboratory, (510) 231-1790\.br\\.br\Duplicate\.br\\.br\Follow-up:\.br\\.br\Acyl Carnitine Panel: Reference Ranges for acylcarnitines are based on specimens collected on newborns who are less than 10 days old. \.br\\.br\Biotinidase Deficiency: This screen for Biotinidase Deficiency was positive. Another specimen MUST be collected on this infant. \.br\\.br\If you have any questions regarding these screening outcomes, please contact the Newborn Screening Staff at at . \.br\\.br\Methods and Limitations:\.br\\.br\Assays for ALD Tier-1, BD, CAH, CF, GAL, MS/MS Acylcarnitine and Amino Acid Panels, PCH, hemoglobinopathies, and SCID were performed at the testing laboratory specified on the front of this report. Assays for ALD Tier-2, CAH Tier-2, Pompe Disease Tier-1, MPS I Tier-1, and SMA were developed and/or optimized by the Genetic Disease Laboratory (GDL), and performed at GDL. Performance characteristics of these assays are determined by GDL. The SMA assay is designed to identify 95% of SMA patients who have homozygous deletions of the SMN1 gene on chromosome 5q. These assays have not been cleared or approved by the U.S. Food and Drug Administration (FDA). The FDA has determined that such clearance or approval is not necessary. The assays are used for clinical purposes. They should not be regarded as investigational or for research. GDL is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA-88) to perform high complexity genetic disease screening. \.br\Attention Healthcare Provider:\.br\\.br\\.br\|||N|||F|||20240711034913 +OBX|7|TX|57129-9^Full newborn screening summary report for display or printing^LN|1||||N|||F|||20240711034913 +OBX|8|ST|57716-3^State printed on filter paper card [Identifier] in NBS card^LN|1|CA|||N|||F|||20240711034913 +OBX|9|NM|8339-4^Birthweight^LN|1|3500|grams||N|||F|||20240711034913 +OBX|10|CE|57722-1^Birth plurality of Pregnancy^LN|1|LA12411-7^Singleton^LN|||N|||F|||20240711034913 +OBX|11|NM|73806-2^Newborn age in hours^LN|1|34|day(s)||N|||F|||20240711034913 +OBX|12|CE|57713-0^Infant NICU factors that affect newborn screening interpretation^LN|1|LA137-2^None^LN|||N|||F|||20240711034913 +OBX|13|CE|67704-7^Feeding types^LN|1|LA16914-6^Breast milk^LN|||N|||F|||20240711034913 +OBX|14|TX|^^^99717-5^Accession Number^L|1|193-08-269/21-2024-21|||N|||F|||20240711034913 +OBX|15|TX|62324-9^Post-discharge provider name^LN|1|EUSTRATIA HUBBARD|||N|||F|||20240711034913 +OBX|16|TX|62327-2^Post-discharge provider practice address^LN|1|N 054TS ARALC, TS102 E SAN DIEGO CA 99999-9999 USA|||N|||F|||20240711034913 +OBX|17|NM|47633-3^Glycine [Moles/volume] in Dried blood spot^LN|1|0.5|µmol/L||N|||F|||20240711034913 +OBX|18|NM|53150-9^Alanine+Beta Alanine+Sarcosine [Moles/volume] in Dried blood spot^LN|1|500|µmol/L|<1000|N|||F|||20240711034913 +OBX|19|NM|47799-2^Valine [Moles/volume] in Dried blood spot^LN|1|0.5|µmol/L||N|||F|||20240711034913 +OBX|20|NM|53151-7^Valine/Phenylalanine [Molar ratio] in Dried blood spot^LN|1|0.00645|{Ratio}|<4.3|N|||F|||20240711034913 +OBX|21|NM|53152-5^Alloisoleucine+Isoleucine+Leucine+Hydroxyproline^LN|1|125|µmol/L|<230|N|||F|||20240711034913 +OBX|22|NM|53154-1^Alloisoleucine+Isoleucine+Leucine+Hydroxyproline/Alanine [Molar ratio] in Dried blood spot^LN|1|0.65|{Ratio}|<1.35|N|||F|||20240711034913 +OBX|23|NM|29573-3^Phenylalanine [Moles/volume] in Dried blood spot^LN|1|77.5|µmol/L|<175|N|||F|||20240711034913 +OBX|24|NM|35572-7^Phenylalanine/Tyrosine [Molar ratio] in Dried blood spot^LN|1|0.75|{Ratio}|<2.6|N|||F|||20240711034913 +OBX|25|NM|35571-9^Tyrosine [Moles/volume] in Dried blood spot^LN|1|425|µmol/L|<680|N|||F|||20240711034913 +OBX|26|NM|53231-7^Succinylacetone [Moles/volume] in Dried blood spot^LN|1|2.25|µmol/L|<6.1|N|||F|||20240711034913 +OBX|27|NM|47700-0^Methionine [Moles/volume] in Dried blood spot^LN|1|27|µmol/L|6.3-100|N|||F|||20240711034913 +OBX|28|NM|42892-0^Citrulline [Moles/volume] in Dried blood spot^LN|1|16.25|µmol/L|5-49|N|||F|||20240711034913 +OBX|29|NM|54092-2^Citrulline/Arginine [Molar ratio] in Dried blood spot^LN|1|3|{Ratio}|<4.8|N|||F|||20240711034913 +OBX|30|NM|53155-8^Asparagine+Ornithine [Moles/volume] in Dried blood spot^LN|1|400|µmol/L|<800|N|||F|||20240711034913 +OBX|31|NM|75215-4^Ornithine/Citrulline [Molar ratio] in Dried blood spot^LN|1|0.5|{Ratio}||N|||F|||20240711034913 +OBX|32|NM|47562-4^Arginine [Moles/volume] in Dried blood spot^LN|1|25|µmol/L|<63|N|||F|||20240711034913 +OBX|33|NM|75214-7^Arginine/Ornithine [Molar ratio] in Dried blood spot^LN|1|0.7|{Ratio}|<1.9|N|||F|||20240711034913 +OBX|34|NM|47732-3^Proline [Moles/volume] in Dried blood spot^LN|1|750|µmol/L|<1500|N|||F|||20240711034913 +OBX|35|TX|57710-6^Amino acidemias newborn screening comment/discussion^LN|1|Negative|||N|||F|||20240711034913 +OBX|36|CE|58088-6^Acylcarnitine newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|37|TX|58093-6^Acylcarnitine newborn screening comment/discussion^LN|1|Negative|||N|||F|||20240711034913 +OBX|38|NM|38481-8^Carnitine.free (C0)^LN|1|33|µmol/L|6.4-125|N|||F|||20240711034913 +OBX|39|NM|53235-8^Carnitine.free (C0)/Palmitoylcarnitine (C16)+Stearoylcarnitine (C18)^LN|1|37.5|{Ratio}|<70|N|||F|||20240711034913 +OBX|40|NM|50157-7^Acetylcarnitine (C2)^LN|1|20.38|µmol/L|10-80|N|||F|||20240711034913 +OBX|41|NM|75212-1^Malonylcarnitine (C3-DC)/Decanoylcarnitine (C10) [Molar ratio] in Dried blood spot^LN|1|0.625|{Ratio}|<7.6|N|||F|||20240711034913 +OBX|42|NM|45211-0^Hexanoylcarnitine (C6)^LN|1|0.48|µmol/L|<0.95|N|||F|||20240711034913 +OBX|43|NM|53175-6^Octanoylcarnitine (C8)^LN|1|0.3|µmol/L|<0.45|N|||F|||20240711034913 +OBX|44|NM|53177-2^Octanoylcarnitine (C8)/Decanoylcarnitine (C10)^LN|1|0.5|{Ratio}||N|||F|||20240711034913 +OBX|45|NM|53174-9^Octenoylcarnitine (C8:1)^LN|1|0.35|µmol/L|<0.65|N|||F|||20240711034913 +OBX|46|NM|45197-1^Decanoylcarnitine (C10)^LN|1|0.32|µmol/L|<0.65|N|||F|||20240711034913 +OBX|47|NM|45198-9^Decenoylcarnitine (C10:1)^LN|1|0.22|µmol/L|<0.45|N|||F|||20240711034913 +OBX|48|NM|45199-7^Dodecanoylcarnitine (C12)^LN|1|1|µmol/L|<2|N|||F|||20240711034913 +OBX|49|NM|45200-3^Dodecenoylcarnitine (C12:1)^LN|1|0.5|µmol/L||N|||F|||20240711034913 +OBX|50|NM|53192-1^Tetradecanoylcarnitine (C14)^LN|1|0.6|µmol/L|<1.2|N|||F|||20240711034913 +OBX|51|NM|53191-3^Tetradecenoylcarnitine (C14:1)^LN|1|0.4|µmol/L|<0.9|N|||F|||20240711034913 +OBX|52|NM|53194-7^Tetradecenoylcarnitine (C14:1)/Dodecenoylcarnitine (C12:1)^LN|1|0.5|{Ratio}||N|||F|||20240711034913 +OBX|53|NM|53190-5^Tetradecadienoylcarnitine (C14:2)^LN|1|0.5|µmol/L||N|||F|||20240711034913 +OBX|54|NM|50281-5^3-Hydroxytetradecanoylcarnitine (C14-OH)^LN|1|0.1|µmol/L|<0.2|N|||F|||20240711034913 +OBX|55|NM|53199-6^Palmitoylcarnitine (C16)^LN|1|5|µmol/L|<12|N|||F|||20240711034913 +OBX|56|NM|53198-8^Palmitoleylcarnitine (C16:1)^LN|1|0.7|µmol/L|<1.4|N|||F|||20240711034913 +OBX|57|NM|50125-4^3-Hydroxypalmitoylcarnitine (C16-OH)^LN|1|0.05|µmol/L|<0.1|N|||F|||20240711034913 +OBX|58|NM|53201-0^3-Hydroxypalmitoylcarnitine (C16-OH)/Palmitoylcarnitine (C16)^LN|1|0.01|{Ratio}|<0.07|N|||F|||20240711034913 +OBX|59|NM|53241-6^Stearoylcarnitine (C18)^LN|1|2|µmol/L|<3.5|N|||F|||20240711034913 +OBX|60|NM|53202-8^Oleoylcarnitine (C18:1)^LN|1|3.5|µmol/L|<7|N|||F|||20240711034913 +OBX|61|NM|45217-7^Linoleoylcarnitine (C18:2)^LN|1|0.5|µmol/L||N|||F|||20240711034913 +OBX|62|NM|50132-0^3-Hydroxystearoylcarnitine (C18-OH)^LN|1|0.05|µmol/L|<0.1|N|||F|||20240711034913 +OBX|63|NM|50113-0^3-Hydroxyoleoylcarnitine (C18:1-OH)^LN|1|0.05|µmol/L|<0.1|N|||F|||20240711034913 +OBX|64|NM|53160-8^Propionylcarnitine (C3)^LN|1|3.15|µmol/L|<7.9|N|||F|||20240711034913 +OBX|65|NM|53163-2^Propionylcarnitine (C3)/Acetylcarnitine (C2)^LN|1|0.15|{Ratio}|<0.42|N|||F|||20240711034913 +OBX|66|NM|67708-8^Malonylcarnitine (C3-DC)+3-Hydroxybutyrylcarnitine (C4-OH)^LN|1|0.2|µmol/L|<0.48|N|||F|||20240711034913 +OBX|67|NM|53166-5^Butyrylcarnitine+Isobutyrylcarnitine (C4)^LN|1|0.85|µmol/L|<1.7|N|||F|||20240711034913 +OBX|68|NM|45216-9^Isovalerylcarnitine+Methylbutyrylcarnitine (C5)^LN|1|0.5|µmol/L|<0.95|N|||F|||20240711034913 +OBX|69|NM|53240-8^Isovalerylcarnitine+Methylbutyrylcarnitine (C5)/Propionylcarnitine (C3)^LN|1|0.15873|{Ratio}|<0.38|N|||F|||20240711034913 +OBX|70|NM|53170-7^Tiglylcarnitine (C5:1)^LN|1|0.3|µmol/L|<0.5|N|||F|||20240711034913 +OBX|71|NM|50106-4^3-Hydroxyisovalerylcarnitine (C5-OH)^LN|1|0.45|µmol/L|<1.15|N|||F|||20240711034913 +OBX|72|NM|67710-4^Glutarylcarnitine (C5-DC)+3-Hydroxyhexanoylcarnitine (C6-OH)^LN|1|0.3|µmol/L|<0.38|N|||F|||20240711034913 +OBX|73|NM|75216-2^Glutarylcarnitine (C5-DC)/Malonylcarnitine (C3-DC) [Molar ratio] in Dried blood spot^LN|1|1.5|{Ratio}|>0.1|N|||F|||20240711034913 +OBX|74|NM|48633-2^Trypsinogen I.free^LN|1|31.0|ng/mL|<69|N|||F|||20240711034913 +OBX|75|CE|46769-6^Cystic fibrosis newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|76|TX|57707-2^Cystic fibrosis newborn screening comment/discussion^LN|1|Negative|||N|||F|||20240711034913 +OBX|77|NM|38473-5^17-Hydroxyprogesterone^LN|1|35|nmol/L|<85|N|||F|||20240711034913 +OBX|78|CE|46758-9^Congenital adrenal hyperplasia newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|79|TX|57706-4^Congenital adrenal hyperplasia newborn screening comment-discussion^LN|1|Negative|||N|||F|||20240711034913 +OBX|80|NM|29575-8^Thyrotropin^LN|1|14.5|mIU/L|<29|N|||F|||20240711034913 +OBX|81|CE|46762-1^Congenital hypothyroidism newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|82|TX|57705-6^Congenital hypothyroidism newborn screening comment-discussion^LN|1|Negative|||N|||F|||20240711034913 +OBX|83|NM|42906-8^Galactose 1 phosphate uridyl transferase^LN|1|55.0|enzyme units|>50|N|||F|||20240711034913 +OBX|84|CE|46737-3^Galactosemias newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|85|TX|57704-9^Galactosemias newborn screening comment-discussion^LN|1|Negative|||N|||F|||20240711034913 +OBX|86|TX|54104-5^Hemoglobin pattern^LN|1|FA||||||F|||20240711034913 +OBX|87|TX|57703-1^Hemoglobin disorders newborn screening comment/discussion^LN|1|Usual hemoglobin pattern. These results assume no transfusion prior to testing and do not rule out the possibility of a thalassemia trait or rare hemoglobin variants.||||||F|||20240711034913 +OBX|88|NM|75217-0^Biotinidase [Enzymatic activity/volume] in Dried blood spot^LN|1|8.0|ERU|>10|L|||F|||20240711034913 +OBX|89|CE|46761-3^Biotinidase deficiency newborn screen interpretation^LN|1|LA18593-6^Out of range^LN|||A|||F|||20240711034913 +OBX|90|TX|57699-1^Biotinidase deficiency newborn screening comment-discussion^LN|1|Positive|||A|||F|||20240711034913 +OBX|91|NM|62320-7^T-cell receptor excision circle [#/volume] in Dried blood spot by Probe and target amplification method^LN|1|33|copies/µL|>18|N|||F|||20240711034913 +OBX|92|CE|62321-5^Severe combined immunodeficiency newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|93|TX|62322-3^Severe combined immunodeficiency newborn screening comment-discussion^LN|1|Negative|||N|||F|||20240711034913 +OBX|94|NM|55827-0^Acid alpha glucosidase [Enzymatic activity/volume] in DBS^LN|1|12.923|µmol/L/h|>=2.079|N|||F|||20240711034913 +OBX|95|CE|63415-4^Pompe Disease deficiency newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|96|TX|63416-2^Pompe Disease deficiency newborn screening comments-discussion^LN|1|Negative|||N|||F|||20240711034913 +OBX|97|NM|55909-6^Alpha-L-iduronidase [Enzymatic activity/volume] in DBS^LN|1|3.117|µmol/L/h|>=1.2204|N|||F|||20240711034913 +OBX|98|CE|79564-1^Mucopolysaccharidosis type I newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|99|TX|79565-8^Mucopolysaccharidosis type I newborn screening comment-discussion^LN|1|Negative|||N|||F|||20240711034913 +OBX|100|TX|^^^99717-60^SMN1 Homozygous Deletion Analysis^L|1|Exon 7 Present||Exon 7 Present|N|||F|||20240711034913 +OBX|101|CE|92004-1^Spinal muscular atrophy newborn screen interpretation^LN|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|102|TX|92003-3^Spinal muscular atrophy newborn screening comment-discussion^LN|1|SMA Negative|||N|||F|||20240711034913 +OBX|103|CE|^^^99717-32^Adrenoleukodystrophy deficiency newborn screening interpretation^L|1|LA18592-8^In range^LN|||N|||F|||20240711034913 +OBX|104|TX|^^^99717-33^Adrenoleukodystrophy deficiency newborn screening comments-discussion^L|1|Negative|||N|||F|||20240711034913 +OBX|105|NM|79321-6^Lysophosphatidylcholine(26:0) [Moles/volume] in Dried blood spot^LN|1|0.2|µmol/L|<0.47|N|||F|||20240711034913 diff --git a/shared/src/main/java/gov/hhs/cdc/trustedintermediary/external/hapi/HapiHelper.java b/shared/src/main/java/gov/hhs/cdc/trustedintermediary/external/hapi/HapiHelper.java index 858d9af86..cc2efdc21 100644 --- a/shared/src/main/java/gov/hhs/cdc/trustedintermediary/external/hapi/HapiHelper.java +++ b/shared/src/main/java/gov/hhs/cdc/trustedintermediary/external/hapi/HapiHelper.java @@ -14,6 +14,7 @@ import org.hl7.fhir.r4.model.Meta; import org.hl7.fhir.r4.model.Organization; import org.hl7.fhir.r4.model.Patient; +import org.hl7.fhir.r4.model.Practitioner; import org.hl7.fhir.r4.model.PractitionerRole; import org.hl7.fhir.r4.model.Resource; import org.hl7.fhir.r4.model.ServiceRequest; @@ -45,9 +46,11 @@ private HapiHelper() {} public static final String EXTENSION_CX5_URL = "CX.5"; public static final StringType EXTENSION_HD1_DATA_TYPE = new StringType("HD.1"); public static final StringType EXTENSION_HD2_HD3_DATA_TYPE = new StringType("HD.2,HD.3"); + public static final StringType EXTENSION_ORC12_DATA_TYPE = new StringType("ORC.12"); public static final StringType EXTENSION_ORC2_DATA_TYPE = new StringType("ORC.2"); public static final StringType EXTENSION_ORC4_DATA_TYPE = new StringType("ORC.4"); public static final StringType EXTENSION_OBR2_DATA_TYPE = new StringType("OBR.2"); + public static final StringType EXTENSION_OBR16_DATA_TYPE = new StringType("OBR.16"); public static final String EXTENSION_CODING_SYSTEM = "https://reportstream.cdc.gov/fhir/StructureDefinition/cwe-coding-system"; @@ -76,6 +79,9 @@ private HapiHelper() {} */ public static Stream resourcesInBundle( Bundle bundle, Class resourceType) { + if (bundle == null || bundle.getEntry() == null) { + return Stream.empty(); + } return bundle.getEntry().stream() .map(Bundle.BundleEntryComponent::getResource) .filter(resource -> resource.getClass().equals(resourceType)) @@ -300,6 +306,10 @@ public static PractitionerRole getPractitionerRole(ServiceRequest serviceRequest return (PractitionerRole) serviceRequest.getRequester().getResource(); } + public static Practitioner getPractitioner(PractitionerRole practitionerRole) { + return (Practitioner) practitionerRole.getPractitioner().getResource(); + } + public static Organization getOrganization(PractitionerRole practitionerRole) { return (Organization) practitionerRole.getOrganization().getResource(); } @@ -473,6 +483,47 @@ public static String getOBR4_1Value(ServiceRequest serviceRequest) { return getCWE1Value(cc.getCoding().get(0)); } + // OBR16 - Ordering Provider + + // OBR16 - + public static void setOBR16WithPractitioner( + Extension obr16Extension, PractitionerRole practitionerRole) { + if (practitionerRole == null) { + return; + } + obr16Extension.setValue(practitionerRole.getPractitioner()); + } + + /** + * Ensures that the extension exists for a given serviceRequest. If the extension does not + * exist, it will create it. + */ + public static Extension ensureExtensionExists( + ServiceRequest serviceRequest, String extensionUrl) { + Extension extension = serviceRequest.getExtensionByUrl(extensionUrl); + if (extension == null) { + // If the extension does not exist, create it and add it to the ServiceRequest + extension = new Extension(extensionUrl); + serviceRequest.addExtension(extension); + } + + return extension; + } + + /** + * Ensures that a sub-extension exists within a parent extension. If the sub-extension does not + * exist, it will create it. + */ + public static Extension ensureSubExtensionExists( + Extension parentExtension, String subExtensionUrl) { + Extension subExtension = parentExtension.getExtensionByUrl(subExtensionUrl); + if (subExtension == null) { + subExtension = new Extension(subExtensionUrl); + parentExtension.addExtension(subExtension); + } + return subExtension; + } + // HD - Hierarchic Designator public static Identifier getHD1Identifier(List identifiers) { List hd1Identifiers = diff --git a/shared/src/test/groovy/gov/hhs/cdc/trustedintermediary/external/hapi/HapiHelperTest.groovy b/shared/src/test/groovy/gov/hhs/cdc/trustedintermediary/external/hapi/HapiHelperTest.groovy index 9390868f6..528381e9a 100644 --- a/shared/src/test/groovy/gov/hhs/cdc/trustedintermediary/external/hapi/HapiHelperTest.groovy +++ b/shared/src/test/groovy/gov/hhs/cdc/trustedintermediary/external/hapi/HapiHelperTest.groovy @@ -7,6 +7,8 @@ import org.hl7.fhir.r4.model.Identifier import org.hl7.fhir.r4.model.MessageHeader import org.hl7.fhir.r4.model.Meta import org.hl7.fhir.r4.model.Patient +import org.hl7.fhir.r4.model.Practitioner +import org.hl7.fhir.r4.model.PractitionerRole import org.hl7.fhir.r4.model.Provenance import org.hl7.fhir.r4.model.Reference import org.hl7.fhir.r4.model.ResourceType @@ -657,6 +659,62 @@ class HapiHelperTest extends Specification { HapiHelper.getOBR4_1Value(sr) == null } + def "ensureExtensionExists returns extension if it exists"() { + given: + def serviceRequest = new ServiceRequest() + final String extensionUrl = "someExtensionUrl" + def expectedExtension = serviceRequest.addExtension().setUrl(extensionUrl) + + when: + def actualExtension = HapiHelper.ensureExtensionExists(serviceRequest, extensionUrl) + + then: + actualExtension == expectedExtension + } + + def "ensureExtensionExists returns a newly created extension if it does not exist"() { + given: + def serviceRequest = new ServiceRequest() + final String extensionUrl = "someExtensionUrl" + + expect: + serviceRequest.getExtensionByUrl(extensionUrl) == null + + when: + def actualExtension = HapiHelper.ensureExtensionExists(serviceRequest, extensionUrl) + + then: + actualExtension == serviceRequest.getExtensionByUrl(extensionUrl) + } + + def "ensureSubExtensionExists returns extension if it exists"() { + given: + def parentExtension = new Extension() + final String subExtensionUrl = "someSubExtensionUrl" + def expectedExtension = parentExtension.addExtension().setUrl(subExtensionUrl) + + when: + def actualExtension = HapiHelper.ensureSubExtensionExists(parentExtension, subExtensionUrl) + + then: + actualExtension == expectedExtension + } + + def "ensureSubExtensionExists returns a newly created extension if it does not exist"() { + given: + def parentExtension = new Extension() + final String subExtensionUrl = "someSubExtensionUrl" + + expect: + parentExtension.getExtensionByUrl(subExtensionUrl) == null + + when: + def actualExtension = HapiHelper.ensureSubExtensionExists(parentExtension, subExtensionUrl) + + then: + actualExtension == parentExtension.getExtensionByUrl(subExtensionUrl) + } + // HD - Hierarchic Designator def "getHD1Identifier returns the correct namespaceIdentifier"() { given: @@ -758,4 +816,39 @@ class HapiHelperTest extends Specification { then: identifiers.first() == identifier } + + def "setOBR16WithPractitioner sets the expected value on an extension"() { + given: + def ext = new Extension() + def role = new PractitionerRole() + def practitioner = new Practitioner() + practitioner.setId("test123") + def ref = new Reference(practitioner.getId()) + role.setPractitioner(ref) + + expect: + ext.getValue() == null + + when: + HapiHelper.setOBR16WithPractitioner(ext, role) + + then: + ext.getValue().getReference() == "test123" + } + + def "setOBR16WithPractitioner does nothing if the provided PractitionerRole is null"() { + given: + def ext = new Extension() + def role = null + + expect: + ext.getValue() == null + + when: + HapiHelper.setOBR16WithPractitioner(ext, role) + + then: + ext.getValue() == null + + } }