You signed in with another tab or window. Reload to refresh your session.You signed out in another tab or window. Reload to refresh your session.You switched accounts on another tab or window. Reload to refresh your session.Dismiss alert
Copy file name to clipboardExpand all lines: README.md
+11-11Lines changed: 11 additions & 11 deletions
Original file line number
Diff line number
Diff line change
@@ -39,24 +39,24 @@ CellCharter is able to automatically identify spatial domains and offers a suite
39
39
40
40
## Features
41
41
42
-
-**Identify niches for multiple samples**: By combining the power of scVI and scArches, CellCharter can identify domains for multiple samples simultaneously, even with in presence of batch effects.
43
-
-**Scalability**: CellCharter can handle large datasets with millions of cells and thousands of features. The possibility to run it on GPUs makes it even faster
44
-
-**Flexibility**: CellCharter can be used with different types of spatial omics data, such as spatial transcriptomics, proteomics, epigenomics and multiomics data. The only difference is the method used for dimensionality reduction and batch effect removal.
45
-
-Spatial transcriptomics: CellCharter has been tested on [scVI](https://docs.scvi-tools.org/en/stable/api/reference/scvi.model.SCVI.html#scvi.model.SCVI) with Zero-inflated negative binomial distribution.
46
-
-Spatial proteomics: CellCharter has been tested on a version of [scArches](https://docs.scarches.org/en/latest/api/models.html#scarches.models.TRVAE), modified to use Mean Squared Error loss instead of the default Negative Binomial loss.
47
-
-Spatial epigenomics: CellCharter has been tested on [scVI](https://docs.scvi-tools.org/en/stable/api/reference/scvi.model.SCVI.html#scvi.model.SCVI) with Poisson distribution.
48
-
-Spatial multiomics: it's possible to use multi-omics models such as [MultiVI](https://docs.scvi-tools.org/en/stable/api/reference/scvi.model.MULTIVI.html#scvi.model.MULTIVI), or use the concatenation of the results from the different models.
49
-
-**Best candidates for the number of domains**: CellCharter offers a [method to find multiple best candidates](https://cellcharter.readthedocs.io/en/latest/generated/cellcharter.tl.ClusterAutoK.html) for the number of domains, based on the stability of a certain number of domains across multiple runs.
50
-
-**Domain characterization**: CellCharter provides a set of tools to characterize and compare the spatial domains, such as domain proportion, cell type enrichment, (differential) neighborhood enrichment, and domain shape characterization.
42
+
-**Identify niches for multiple samples**: By combining the power of scVI and scArches, CellCharter can identify domains for multiple samples simultaneously, even with in presence of batch effects.
43
+
-**Scalability**: CellCharter can handle large datasets with millions of cells and thousands of features. The possibility to run it on GPUs makes it even faster
44
+
-**Flexibility**: CellCharter can be used with different types of spatial omics data, such as spatial transcriptomics, proteomics, epigenomics and multiomics data. The only difference is the method used for dimensionality reduction and batch effect removal.
45
+
- Spatial transcriptomics: CellCharter has been tested on [scVI](https://docs.scvi-tools.org/en/stable/api/reference/scvi.model.SCVI.html#scvi.model.SCVI) with Zero-inflated negative binomial distribution.
46
+
- Spatial proteomics: CellCharter has been tested on a version of [scArches](https://docs.scarches.org/en/latest/api/models.html#scarches.models.TRVAE), modified to use Mean Squared Error loss instead of the default Negative Binomial loss.
47
+
- Spatial epigenomics: CellCharter has been tested on [scVI](https://docs.scvi-tools.org/en/stable/api/reference/scvi.model.SCVI.html#scvi.model.SCVI) with Poisson distribution.
48
+
- Spatial multiomics: it's possible to use multi-omics models such as [MultiVI](https://docs.scvi-tools.org/en/stable/api/reference/scvi.model.MULTIVI.html#scvi.model.MULTIVI), or use the concatenation of the results from the different models.
49
+
-**Best candidates for the number of domains**: CellCharter offers a [method to find multiple best candidates](https://cellcharter.readthedocs.io/en/latest/generated/cellcharter.tl.ClusterAutoK.html) for the number of domains, based on the stability of a certain number of domains across multiple runs.
50
+
-**Domain characterization**: CellCharter provides a set of tools to characterize and compare the spatial domains, such as domain proportion, cell type enrichment, (differential) neighborhood enrichment, and domain shape characterization.
51
51
52
52
Since CellCharter 0.3.0, we moved the implementation of the Gaussian Mixture Model (GMM) from [PyCave](https://github.com/borchero/pycave), not maintained anymore, to [TorchGMM](https://github.com/CSOgroup/torchgmm), a fork of PyCave maintained by the CSOgroup. This change allows us to have a more stable and maintained implementation of GMM that is compatible with the most recent versions of PyTorch.
53
53
54
54
## Getting started
55
55
56
56
Please refer to the [documentation][link-docs]. In particular, the
0 commit comments