diff --git a/packages/beacon-node/vitest.e2e.config.ts b/packages/beacon-node/vitest.e2e.config.ts
index b9f913705ef2..18034e3eedd1 100644
--- a/packages/beacon-node/vitest.e2e.config.ts
+++ b/packages/beacon-node/vitest.e2e.config.ts
@@ -1,9 +1,13 @@
 import {defineConfig, mergeConfig} from "vitest/config";
+import {buildTargetPlugin} from "../../scripts/vitest/plugins/buildTargetPlugin";
 import vitestConfig from "../../vitest.base.e2e.config";
 
 export default mergeConfig(
   vitestConfig,
   defineConfig({
+    // We need to change the build target to test code which is based on `using` keyword
+    // Note this target is not fully supported for the browsers
+    plugins: [buildTargetPlugin("es2022")],
     test: {
       globalSetup: ["./test/globalSetup.ts"],
     },
diff --git a/packages/beacon-node/vitest.spec.config.ts b/packages/beacon-node/vitest.spec.config.ts
index f4f301c7985f..5a34374d2374 100644
--- a/packages/beacon-node/vitest.spec.config.ts
+++ b/packages/beacon-node/vitest.spec.config.ts
@@ -1,9 +1,13 @@
 import {defineConfig, mergeConfig} from "vitest/config";
+import {buildTargetPlugin} from "../../scripts/vitest/plugins/buildTargetPlugin";
 import vitestConfig from "../../vitest.base.spec.config";
 
 export default mergeConfig(
   vitestConfig,
   defineConfig({
+    // We need to change the build target to test code which is based on `using` keyword
+    // Note this target is not fully supported for the browsers
+    plugins: [buildTargetPlugin("es2022")],
     test: {
       globalSetup: ["./test/globalSetup.ts"],
     },