From 651a8bb693e42b901f7f0cf793b0ea28bf019e45 Mon Sep 17 00:00:00 2001 From: Martin Beracochea Date: Wed, 12 Jul 2023 12:25:28 +0100 Subject: [PATCH 01/24] Initial port of the analysis XML dump generation for EBI Search. This is a WIP, but the analysis should be nearly done. I've moved the logic for "Runs" of EBI Search Dump: - Code that reads the analysis data from the DB and flat files -> https://github.com/EBI-Metagenomics/MetagenomicsSearchDump/blob/master/src/input/metagenomicsDB.py#L191 - I've replaced the file reading bits with calls to Mongo / MySQL. Which makes the code independent from the filesystem. - Code that generates the xml output file for **one** analysis: https://github.com/EBI-Metagenomics/MetagenomicsSearchDump/blob/master/src/output/run.py We need to port the Samples and Studies; and the analysis aggregation. The aggregation is required to merge the analysis into XML bundles that EBI Search ingest. AnalysesAggregation script -> https://github.com/EBI-Metagenomics/MetagenomicsSearchDump/blob/master/src/RunEntryAggregator.py Another task: Is to add a indexed_at field on Analyses, Samples and Studies. This is going to be useful to have incremental dump generation, instead of having to re-generate all the files. Moving to this will also required the modification of the AnalysesAggregation script OR for us to move to EBI Search incremental dumps (https://www.ebi.ac.uk/seqdb/confluence/display/EXT/Preparation+for+incremental+indexing) Last one. EBI Search also supports JSONs (https://www.ebi.ac.uk/seqdb/confluence/display/EXT/JSON+data+format) --- .gitignore | 2 - .../commands/ebi_search_analysis_dump.py | 167 + emgapi/templates/ebi_search/analysis.xml | 69 + .../ebi_search/example_MGYA00238154.xml | 17205 +++++++++++ .../ebi_search/example_MGYA00374984.xml | 24630 ++++++++++++++++ 5 files changed, 42071 insertions(+), 2 deletions(-) create mode 100644 emgapi/management/commands/ebi_search_analysis_dump.py create mode 100644 emgapi/templates/ebi_search/analysis.xml create mode 100644 emgapi/templates/ebi_search/example_MGYA00238154.xml create mode 100644 emgapi/templates/ebi_search/example_MGYA00374984.xml diff --git a/.gitignore b/.gitignore index 1869a6a77..1657267e9 100644 --- a/.gitignore +++ b/.gitignore @@ -8,7 +8,6 @@ dist emgcli.egg-info/ .pytest_cache/ - staticfiles/ media/ venv/ @@ -20,7 +19,6 @@ fixtures/*.sig # IntelliJ project structure files *.iml -*.xml .idea/ .coverage diff --git a/emgapi/management/commands/ebi_search_analysis_dump.py b/emgapi/management/commands/ebi_search_analysis_dump.py new file mode 100644 index 000000000..773f80feb --- /dev/null +++ b/emgapi/management/commands/ebi_search_analysis_dump.py @@ -0,0 +1,167 @@ +#!/usr/bin/env python +# -*- coding: utf-8 -*- + +# Copyright 2017-2023 EMBL - European Bioinformatics Institute +# +# Licensed under the Apache License, Version 2.0 (the "License"); +# you may not use this file except in compliance with the License. +# You may obtain a copy of the License at +# http://www.apache.org/licenses/LICENSE-2.0 +# +# Unless required by applicable law or agreed to in writing, software +# distributed under the License is distributed on an "AS IS" BASIS, +# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. +# See the License for the specific language governing permissions and +# limitations under the License. + +import logging +import re + +from django.core.management import BaseCommand +from django.template.loader import render_to_string + +from emgapi.models import AnalysisJob +from emgapianns.models import ( + AnalysisJobTaxonomy, + AnalysisJobGoTerm, + AnalysisJobInterproIdentifier, +) + +logger = logging.getLogger(__name__) + + +class Command(BaseCommand): + help = "Generate the XML dump of an analysis." + + def add_arguments(self, parser): + super(Command, self).add_arguments(parser) + parser.add_argument( + "-a", "--accession", help="Analysis accession", required=True + ) + parser.add_argument("-o", "--output", help="Output xml file", required=True) + + # TODO: this was ported directly from EBI Search Dump + # we need to improve it, maybe move it to a template tag? + # TODO: apply this to InterPro and GO annotations + def unicode_and_clean(self, identifier, text): + """Converts text to utf8 encoded string with xml subsitutions""" + if not text: + return text + try: + text = text.encode("utf8", "strict") + except Exception as ex: + match = re.search(r"in position (\d+)", str(ex)) + if match: + position = int(match.group(1)) + matchStart = position - 15 + if matchStart < 0: + matchStart = 0 + matchEnd = position + 15 + if matchEnd > len(text): + matchEnd = len(text) + logger.error( + f"Replacing '{identifier}' in {text[position]} [{text[matchStart:matchEnd]}]", + ex, + ) + text = text[:position] + text[position + 1 :] + text = self.unicode_and_clean(identifier, text) + else: + logger.error(f"Failed to convert: {identifier}.", ex) + return text.decode("utf8") + + def handle(self, *args, **options): + """Render an analysis using the EBI Search XML template""" + # TODO: The migration for the analysis should be nearly done, code ported from: https://github.com/EBI-Metagenomics/MetagenomicsSearchDump + # In that repo the analyses corresponds to the Run entries. + accession: str = options["accession"] + analysis: AnalysisJob = AnalysisJob.objects.get(job_id=accession) + analysis_taxonomy: AnalysisJobTaxonomy = AnalysisJobTaxonomy.objects.get( + analysis_id=str(analysis.job_id) + ) + go_annotation: AnalysisJobGoTerm = AnalysisJobGoTerm.objects.get( + pk=str(analysis.job_id) + ) + ips_annotation: AnalysisJobInterproIdentifier = AnalysisJobInterproIdentifier.objects.get( + pk=str(analysis.job_id) + ) + + biome_list = analysis.study.biome.lineage.split(":")[1:] + + taxonomy_lists = [] + taxonomy_attributes = [ + analysis_taxonomy.taxonomy, + analysis_taxonomy.taxonomy_ssu, + analysis_taxonomy.taxonomy_lsu, + analysis_taxonomy.taxonomy_itsonedb, + analysis_taxonomy.taxonomy_itsunite, + ] + for taxonomy_attribute in taxonomy_attributes: + if taxonomy_attribute: + for tax in taxonomy_attribute: + tax_lineage_list = list(filter(None, tax.lineage.split(":"))) + if len(tax_lineage_list) > 1: + taxonomy_lists.append( + [ + self.unicode_and_clean("tax", tax_el) + for tax_el in tax_lineage_list + ] + ) + + # TODO: port these metadata "cleaning" rules. + # if depth and len(depth) > 0: + # self.depth = checkIfNumerical(extID, depth) + # if altitude and len(altitude) > 0: + # self.altitude = checkIfNumerical(extID, altitude) + # if elevation and len(elevation) > 0: + # self.elevation = checkIfNumerical(extID, elevation) + # if salinity and len(salinity) > 0: + # self.salinity = checkIfNumerical(extID, salinity) + # if temperature and len(temperature) > 0: + # self.temperature = checkIfNumerical(extID, temperature) + # if pH and len(pH) > 0: + # self.pH = checkIfNumerical(extID, pH[0]) + # if longitudeStart and len(longitudeStart) > 0: + # self.longitudeStart = encodeToUnicodeAndClean(extID, longitudeStart) + # if longitudeEnd and len(longitudeEnd) > 0: + # self.longitudeEnd = checkIfNumerical(extID, longitudeEnd) + # if latitudeStart and len(latitudeStart) > 0: + # self.latitudeStart = checkIfNumerical(extID, latitudeStart) + # if latitudeEnd and len(latitudeEnd) > 0: + # self.latitudeEnd = checkIfNumerical(extID, latitudeEnd) + + # TODO: from this list (taken from ) + SAMPLE_ANNOTATIONS_ACCEPT_LIST = { + "temperature": "temperature", + "pH": "pH", + "altitude": "altitude", + "depth": "depth", + "elevation": "elevation", + "geographic location (elevation)": "elevation", + "geographic location (depth)": "depth", + "salinity": "salinity", + "longitude start": "longitudeStart", + "latitude start": "latitudeStart", + "longitude end": "longitudeEnd", + "latitude end": "latitudeEnd", + } + + sample_metadata = {} + for sample_metadata_entry in analysis.sample.metadata.all(): + if sample_metadata_entry.var.var_name in SAMPLE_ANNOTATIONS_ACCEPT_LIST: + sample_metadata[ + SAMPLE_ANNOTATIONS_ACCEPT_LIST[sample_metadata_entry.var.var_name] + ] = sample_metadata_entry.var_val_ucv + + print( + render_to_string( + "ebi_search/analysis.xml", + { + "analysis": analysis, + "analysis_biome": biome_list, + "analysis_taxonomies": taxonomy_lists, + "analysis_go_entries": go_annotation.go_terms, + "analysis_ips_entries": ips_annotation.interpro_identifiers, + "sample_metadata": sample_metadata, + }, + ) + ) diff --git a/emgapi/templates/ebi_search/analysis.xml b/emgapi/templates/ebi_search/analysis.xml new file mode 100644 index 000000000..dd06c1c95 --- /dev/null +++ b/emgapi/templates/ebi_search/analysis.xml @@ -0,0 +1,69 @@ + + {{ analysis.accession }} + + + + + + assembly + {{ analysis.pipeline.release_version }} + {{ analysis.sample.sample_name }} + {{ analysis.study.study_name }} + {{ analysis.study.biome.biome_name }} + + {% for biome_element in analysis_biome %} + {% if forloop.first %} + {{ biome_element }} + {% else %} + {{ biome_element }} + {% endif %} + {% endfor %} + + {% for taxonomy_lineage_elements in analysis_taxonomies %} + + {% for taxonomy_element in taxonomy_lineage_elements %} + {% if forloop.first %} + {{ taxonomy_element }} + {% else %} + {{ taxonomy_element }} + {% endif %} + {% endfor %} + + {% endfor %} + + {% for go_slim in analysis_go_slim_entries %} + {{ go_slim.description }} + {% endfor %} + + {% for ips in analysis_ips_entries %} + {{ ips.description }} + {% endfor %} + + {% for metadata_key, metadata_value in sample_metadata.items %} + {{ metadata_value }} + {% endfor %} + + + + + + + + {# Assembly analysis #} + {% if analysis.assembly and analysis.assembly.accession|slice:":4" == "GCA_" %} + + + {% endif %} + + {# WGS/Amplicon analysis #} + {% if analysis.run %} + + {% endif %} + {% for go in analysis_go_entries %} + + {% endfor %} + {% for ips in analysis_ips_entries %} + + {% endfor %} + + \ No newline at end of file diff --git a/emgapi/templates/ebi_search/example_MGYA00238154.xml b/emgapi/templates/ebi_search/example_MGYA00238154.xml new file mode 100644 index 000000000..e4fe8b45e --- /dev/null +++ b/emgapi/templates/ebi_search/example_MGYA00238154.xml @@ -0,0 +1,17205 @@ + + MGYA00238154 + + + + + + assembly + 4.1 + Gp0206847 + EMG produced TPA metagenomics assembly of the Chrysochromulina tobin associated microbial communities from unialgal haptophyte culture, Washington, USA - P5_4mM MetaG metagenome (mixed culture metagenome) data set. + Brackish + + Environmental + Aquatic + Lentic + Brackish + + oxidation-reduction process + metabolic process + transmembrane transport + protein phosphorylation + regulation of transcription, DNA-templated + proteolysis + transport + translation + carbohydrate metabolic process + ion transport + microtubule-based movement + biosynthetic process + protein folding + DNA repair + signal transduction + cell redox homeostasis + DNA recombination + protein ubiquitination + lipid metabolic process + tRNA aminoacylation for protein translation + DNA integration + phosphorelay signal transduction system + RNA processing + protein glycosylation + intracellular protein transport + DNA replication + potassium ion transport + transcription, DNA-templated + nucleobase-containing compound metabolic process + pseudouridine synthesis + protein peptidyl-prolyl isomerization + cation transport + tRNA processing + RNA modification + cellular protein modification process + ubiquitin-dependent protein catabolic process + vesicle-mediated transport + glycolytic process + nitrogen compound metabolic process + dephosphorylation + methylation + phosphorylation + rRNA processing + protein ADP-ribosylation + protein deubiquitination + cellular amino acid metabolic process + fatty acid biosynthetic process + metal ion transport + intracellular signal transduction + ATP synthesis coupled proton transport + DNA topological change + carbohydrate transport + photosynthesis + tricarboxylic acid cycle + tRNA modification + protein transport + magnesium ion transport + DNA-templated transcription, initiation + fatty acid metabolic process + tRNA aminoacylation + potassium ion transmembrane transport + cyclic nucleotide biosynthetic process + peptidyl-amino acid modification + histidine biosynthetic process + nucleoside metabolic process + response to stress + lipid biosynthetic process + protein secretion + drug transmembrane transport + response to oxidative stress + base-excision repair + mismatch repair + translational initiation + cellular aromatic compound metabolic process + sodium ion transport + isoprenoid biosynthetic process + pathogenesis + nucleotide-excision repair + transposition, DNA-mediated + lysine biosynthetic process via diaminopimelate + glucose metabolic process + DNA methylation + porphyrin-containing compound biosynthetic process + ammonium transport + proteolysis involved in cellular protein catabolic process + DNA replication initiation + cytochrome complex assembly + amino acid transmembrane transport + Mo-molybdopterin cofactor biosynthetic process + sulfate transport + ATP hydrolysis coupled proton transport + purine nucleotide biosynthetic process + phospholipid biosynthetic process + tetrapyrrole biosynthetic process + cobalamin biosynthetic process + translational elongation + microtubule-based process + aromatic amino acid family biosynthetic process + riboflavin biosynthetic process + protein metabolic process + protein catabolic process + ribosome biogenesis + 'de novo' pyrimidine nucleobase biosynthetic process + translational termination + SRP-dependent cotranslational protein targeting to membrane + proton transport + protein import + aromatic compound catabolic process + carboxylic acid metabolic process + phosphatidylinositol phosphorylation + telomere maintenance + galactose metabolic process + ubiquinone biosynthetic process + superoxide metabolic process + iron-sulfur cluster assembly + electron transport chain + bacterial-type flagellum-dependent cell motility + gluconeogenesis + 'de novo' IMP biosynthetic process + cysteine biosynthetic process from serine + ATP synthesis coupled electron transport + trehalose biosynthetic process + DNA metabolic process + arginine biosynthetic process + glutathione catabolic process + terpenoid biosynthetic process + phosphatidylinositol metabolic process + intermembrane lipid transfer + nucleosome assembly + mRNA processing + glutathione biosynthetic process + cell adhesion + aerobic respiration + aromatic amino acid family metabolic process + nucleotide catabolic process + ER to Golgi vesicle-mediated transport + vesicle docking involved in exocytosis + negative regulation of transcription, DNA-templated + mRNA splicing, via spliceosome + pyrimidine nucleotide biosynthetic process + tryptophan metabolic process + regulation of pH + vacuolar transport + methionine biosynthetic process + leucine biosynthetic process + lipid A biosynthetic process + folic acid-containing compound biosynthetic process + molybdate ion transport + peptide transport + heme transport + coenzyme A biosynthetic process + guanosine tetraphosphate metabolic process + nitrate assimilation + tRNA threonylcarbamoyladenosine modification + glycerol-3-phosphate metabolic process + nucleoside diphosphate phosphorylation + GTP biosynthetic process + UTP biosynthetic process + CTP biosynthetic process + DNA modification + glycyl-tRNA aminoacylation + glutamate biosynthetic process + protein targeting + cell cycle + queuosine biosynthetic process + cellular amino acid biosynthetic process + branched-chain amino acid biosynthetic process + purine nucleobase biosynthetic process + thiamine biosynthetic process + peptidoglycan biosynthetic process + regulation of ARF protein signal transduction + ATP metabolic process + protein targeting to Golgi + fructose metabolic process + valyl-tRNA aminoacylation + proline biosynthetic process + L-serine biosynthetic process + calcium ion transport + phosphate ion transport + G-protein coupled receptor signaling pathway + NAD biosynthetic process + polysaccharide transport + virion assembly + regulation of Rho protein signal transduction + cell division + ammonium transmembrane transport + polysaccharide biosynthetic process + glycerol metabolic process + (1->3)-beta-D-glucan biosynthetic process + glyoxylate cycle + transcription initiation from RNA polymerase II promoter + arginyl-tRNA aminoacylation + isoleucyl-tRNA aminoacylation + methionine metabolic process + heme biosynthetic process + phosphate-containing compound metabolic process + chloride transport + amino acid transport + microtubule nucleation + regulation of cell shape + peptidoglycan catabolic process + protein secretion by the type II secretion system + pantothenate biosynthetic process + carotenoid biosynthetic process + photosynthesis, light reaction + respiratory electron transport chain + protein refolding + cellular metabolic process + protein insertion into membrane + protein homooligomerization + chromosome organization + cilium assembly + calcium ion transmembrane transport + organic substance metabolic process + carbohydrate derivative metabolic process + microtubule cytoskeleton organization + cell morphogenesis + mannose metabolic process + regulation of transcription from RNA polymerase II promoter + tRNA splicing, via endonucleolytic cleavage and ligation + alanyl-tRNA aminoacylation + phenylalanyl-tRNA aminoacylation + glutamine biosynthetic process + glycine catabolic process + L-phenylalanine catabolic process + polyamine biosynthetic process + steroid biosynthetic process + cytoskeleton organization + cell communication + lipoate biosynthetic process + nucleotide metabolic process + nucleoside triphosphate catabolic process + nucleotide biosynthetic process + chromate transport + lipid catabolic process + protein processing + histone deacetylation + chromosome condensation + tRNA methylation + retrograde transport, endosome to Golgi + pteridine-containing compound metabolic process + poly-hydroxybutyrate biosynthetic process + glycerol-3-phosphate catabolic process + tetrahydrofolate metabolic process + Golgi vesicle transport + DNA ligation involved in DNA repair + rRNA base methylation + protein maturation by iron-sulfur cluster transfer + regulation of cyclin-dependent protein serine/threonine kinase activity + pentose-phosphate shunt + purine nucleotide metabolic process + inosine salvage + dTMP biosynthetic process + DNA-dependent DNA replication + DNA catabolic process + DNA-templated transcription, termination + methionyl-tRNA aminoacylation + signal peptide processing + N-terminal protein amino acid methylation + GPI anchor biosynthetic process + glutamine metabolic process + tyrosine metabolic process + glycerol ether metabolic process + heme a biosynthetic process + anion transport + chemotaxis + immune response + small GTPase mediated signal transduction + isoleucine biosynthetic process + thiamine diphosphate biosynthetic process + phosphoenolpyruvate-dependent sugar phosphotransferase system + response to heat + SOS response + photosynthetic electron transport chain + negative regulation of centrosome duplication + carbon utilization + histone acetylation + tryptophan catabolic process to kynurenine + lipid glycosylation + regulation of actin filament polymerization + regulation of DNA-templated transcription, elongation + Arp2/3 complex-mediated actin nucleation + peptide biosynthetic process + primary metabolic process + formaldehyde catabolic process + chorismate metabolic process + N-4 methylation of cytosine + sulfate assimilation + rRNA modification + selenocysteine incorporation + tRNA wobble uridine modification + fructose 2,6-bisphosphate metabolic process + ethanol oxidation + pyruvate metabolic process + GMP biosynthetic process + double-strand break repair via nonhomologous end joining + glutamyl-tRNA aminoacylation + leucyl-tRNA aminoacylation + lysyl-tRNA aminoacylation + prolyl-tRNA aminoacylation + seryl-tRNA aminoacylation + threonyl-tRNA aminoacylation + tryptophanyl-tRNA aminoacylation + translational frameshifting + protein N-linked glycosylation + protein O-linked glycosylation + arginine metabolic process + sphingolipid metabolic process + ceramide metabolic process + one-carbon metabolic process + heme oxidation + cellular iron ion homeostasis + retrograde vesicle-mediated transport, Golgi to ER + intra-Golgi vesicle-mediated transport + autophagy + multicellular organism development + pyridoxine biosynthetic process + pentose-phosphate shunt, non-oxidative branch + branched-chain amino acid metabolic process + threonine biosynthetic process + L-phenylalanine biosynthetic process + lipopolysaccharide biosynthetic process + glycolipid biosynthetic process + DNA restriction-modification system + photosynthetic electron transport in photosystem II + response to metal ion + chlorophyll biosynthetic process + carbohydrate catabolic process + RNA metabolic process + peroxisome fission + poly(A)+ mRNA export from nucleus + cell wall macromolecule catabolic process + antibiotic biosynthetic process + pyrroloquinoline quinone biosynthetic process + acetyl-CoA biosynthetic process from acetate + aerobic electron transport chain + cellulose catabolic process + molybdopterin cofactor biosynthetic process + phosphate ion transmembrane transport + lipoprotein biosynthetic process + photosystem II stabilization + proteasome-mediated ubiquitin-dependent protein catabolic process + proteasome assembly + cellular respiration + positive regulation of translational elongation + positive regulation of translational termination + response to antibiotic + carbohydrate phosphorylation + phytochelatin biosynthetic process + glucose 6-phosphate metabolic process + nuclear-transcribed mRNA catabolic process, nonsense-mediated decay + allantoin catabolic process + mitotic cell cycle + trehalose metabolic process + fructose 6-phosphate metabolic process + acetyl-CoA biosynthetic process from pyruvate + dTDP biosynthetic process + DNA replication, synthesis of RNA primer + regulation of DNA replication + double-strand break repair + chromatin remodeling + transcription from RNA polymerase II promoter + cysteinyl-tRNA aminoacylation + histidyl-tRNA aminoacylation + tyrosyl-tRNA aminoacylation + C-terminal protein methylation + cysteine metabolic process + S-adenosylmethionine biosynthetic process + protein import into nucleus + protein retention in ER lumen + tetrahydrobiopterin biosynthetic process + ATP biosynthetic process + folic acid-containing compound metabolic process + regulation of nitrogen utilization + oligopeptide transport + cellular amino acid catabolic process + biotin biosynthetic process + peptidoglycan turnover + deoxyribonucleotide catabolic process + DNA mediated transformation + GDP-mannose biosynthetic process + regulation of signal transduction + phospholipid transport + coenzyme A metabolic process + protein arginylation + protein flavinylation + peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase + peptidyl-pyrromethane cofactor linkage + methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione + isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway + pyridine nucleotide biosynthetic process + glycine decarboxylation via glycine cleavage system + L-lysine catabolic process to acetate + glutamate catabolic process to 2-oxoglutarate + 3,4-dihydroxybenzoate catabolic process + GDP-mannose metabolic process + pyrimidine nucleobase biosynthetic process + actin filament polymerization + cellular phosphate ion homeostasis + rRNA methylation + response to ATP + galactose catabolic process via UDP-galactose + copper ion transmembrane transport + arginine biosynthetic process via ornithine + regulation of GTPase activity + proton-transporting ATP synthase complex assembly + 'de novo' UMP biosynthetic process + cellular biosynthetic process + negative regulation of phosphate metabolic process + inositol phosphate dephosphorylation + heme O biosynthetic process + dimethylallyl diphosphate biosynthetic process + barbed-end actin filament capping + cofactor biosynthetic process + protein tetramerization + DNA biosynthetic process + cation transmembrane transport + tRNA-guanine transglycosylation + DNA damage checkpoint + tryptophan biosynthetic process + double-strand break repair via homologous recombination + DNA catabolic process, endonucleolytic + RNA methylation + tRNA wobble adenosine to inosine editing + glucose catabolic process + D-ribose metabolic process + inositol biosynthetic process + amino sugar metabolic process + isocitrate metabolic process + fumarate metabolic process + malate metabolic process + regulation of carbohydrate metabolic process + mitochondrial electron transport, NADH to ubiquinone + mitochondrial electron transport, ubiquinol to cytochrome c + guanine catabolic process + purine ribonucleoside salvage + regulation of DNA repair + chromatin assembly or disassembly + transcription elongation from RNA polymerase II promoter + 7-methylguanosine mRNA capping + transcription from RNA polymerase III promoter + mRNA catabolic process + regulation of translational fidelity + protein complex assembly + N-terminal protein amino acid acetylation + protein methylation + dolichol-linked oligosaccharide biosynthetic process + alanine metabolic process + glycine biosynthetic process + threonine metabolic process + tryptophan catabolic process + tyrosine biosynthetic process + thiamine metabolic process + phosphorus metabolic process + polyphosphate biosynthetic process + nitric oxide biosynthetic process + mitochondrial pyruvate transport + endocytosis + peroxisome organization + mitotic sister chromatid cohesion + mitotic chromosome condensation + protein kinase C-activating G-protein coupled receptor signaling pathway + spermidine biosynthetic process + RNA splicing + coenzyme biosynthetic process + purine ribonucleotide biosynthetic process + ribonucleoside monophosphate biosynthetic process + menaquinone biosynthetic process + protein lipoylation + Entner-Doudoroff pathway through 6-phosphogluconate + nitrogen fixation + toxin biosynthetic process + pyridoxal 5'-phosphate salvage + putrescine biosynthetic process + 7-methylguanosine RNA capping + detection of visible light + flavonoid biosynthetic process + cytidine deamination + response to organic substance + photosystem II assembly + monovalent inorganic cation transport + polyamine transport + formate oxidation + carbon fixation + chlorophyll catabolic process + cellular component organization + carbohydrate biosynthetic process + attachment of GPI anchor to protein + histone modification + protein-heme linkage + peptidyl-glutamic acid carboxylation + peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid + protein prenylation + modulation by virus of host morphology or physiology + response to pheromone + UDP-N-acetylgalactosamine biosynthetic process + inositol catabolic process + siroheme biosynthetic process + allantoin biosynthetic process + removal of superoxide radicals + L-methionine salvage from methylthioadenosine + organic phosphonate catabolic process + actin cytoskeleton organization + regulation of mitotic metaphase/anaphase transition + protein import into mitochondrial matrix + cellulose biosynthetic process + beta-lactam antibiotic catabolic process + mRNA 3'-end processing + arabinan metabolic process + regulation of DNA-templated transcription, termination + regulation of TOR signaling + alanine transport + DNA duplex unwinding + ion transmembrane transport + mitochondrial respiratory chain complex III assembly + iron ion transmembrane transport + intraciliary transport + mature ribosome assembly + cellular modified amino acid biosynthetic process + L-alanine catabolic process + lipoprotein transport + negative regulation of apoptotic process + positive regulation of catalytic activity + Gram-negative-bacterium-type cell outer membrane assembly + urea catabolic process + maintenance of CRISPR repeat elements + RNA polyadenylation + regulation of phosphoprotein phosphatase activity + protein transport by the Tat complex + AMP salvage + bacterial-type flagellum assembly + bacterial-type flagellum organization + glycerolipid biosynthetic process + protein targeting to ER + extracellular polysaccharide biosynthetic process + positive regulation of Notch signaling pathway + positive regulation of transcription, DNA-templated + dUTP metabolic process + 2-keto-3-deoxygluconate transport + tetrahydrofolate biosynthetic process + intracellular transport + vesicle fusion with Golgi apparatus + cell motility + chromosome separation + defense response to virus + copper ion homeostasis + membrane organization + cell wall organization + membrane assembly + alpha-tubulin acetylation + carbohydrate derivative biosynthetic process + p-aminobenzoyl-glutamate transmembrane transport + autophagosome assembly + negative regulation of transcription from RNA polymerase II promoter + spliceosomal complex assembly + peptidoglycan metabolic process + deadenylation-dependent decapping of nuclear-transcribed mRNA + response to reactive oxygen species + generation of catalytic spliceosome for second transesterification step + spliceosomal snRNP assembly + maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) + cleavage involved in rRNA processing + conjugation + regulation of neurotransmitter levels + tRNA 5'-leader removal + polysaccharide metabolic process + monosaccharide metabolic process + fucose metabolic process + UDP-glucose metabolic process + chitin metabolic process + N-acetylglucosamine metabolic process + glucuronate catabolic process + organic acid metabolic process + citrate metabolic process + purine nucleobase metabolic process + IMP biosynthetic process + pyrimidine nucleobase metabolic process + pyrimidine nucleoside metabolic process + uracil salvage + dUTP biosynthetic process + plasmid maintenance + mRNA splice site selection + mRNA cleavage + RNA catabolic process + asparaginyl-tRNA aminoacylation + aspartyl-tRNA aminoacylation + regulation of translational initiation + protein dephosphorylation + arginine catabolic process + asparagine biosynthetic process + glycine metabolic process + threonine catabolic process + spermine biosynthetic process + protein targeting to mitochondrion + phospholipid metabolic process + galactosylceramide catabolic process + NADPH regeneration + NADP biosynthetic process + NADP catabolic process + glutathione metabolic process + sulfur compound metabolic process + copper ion transport + iron ion transport + neurotransmitter transport + lipid transport + exocytosis + nucleocytoplasmic transport + defense response + cellular response to DNA damage stimulus + tubulin complex assembly + post-chaperonin tubulin folding pathway + mitotic spindle assembly checkpoint + regulation of exit from mitosis + reciprocal meiotic recombination + Notch signaling pathway + peptidyl-lysine modification to peptidyl-hypusine + catabolic process + nucleoside catabolic process + purine ribonucleoside monophosphate biosynthetic process + nucleotide-sugar metabolic process + phage shock + amine metabolic process + oligosaccharide biosynthetic process + 2'-deoxyribonucleotide metabolic process + gamma-aminobutyric acid metabolic process + gamma-aminobutyric acid catabolic process + response to toxic substance + photosynthetic electron transport in photosystem I + nodulation + phytochromobilin biosynthetic process + phenylacetate catabolic process + negative regulation of phosphatase activity + ferrous iron transport + organic phosphonate transport + galactose transport + glucose transport + choline transport + siderophore transport + formate metabolic process + rRNA catabolic process + sterol metabolic process + protein-phycocyanobilin linkage + peptidyl-diphthamide biosynthetic process from peptidyl-histidine + viral DNA genome packaging + viral genome replication + glycine betaine biosynthetic process from choline + isopentenyl diphosphate biosynthetic process, mevalonate pathway + cysteine biosynthetic process via cystathionine + dolichol metabolic process + sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) + sulfur oxidation + sulfate reduction + histidine catabolic process to glutamate and formamide + mannitol metabolic process + urea metabolic process + organic phosphonate metabolic process + NAD metabolic process + lipid storage + bacteriocin immunity + protein secretion by the type IV secretion system + prenylcysteine catabolic process + cytoplasmic microtubule organization + anaphase-promoting complex-dependent catabolic process + posttranslational protein targeting to membrane, translocation + glycine betaine transport + cardiolipin biosynthetic process + regulation of barrier septum assembly + inositol trisphosphate metabolic process + positive regulation of transcription elongation from RNA polymerase II promoter + fatty acid beta-oxidation using acyl-CoA dehydrogenase + gamma-tubulin complex localization + mitochondrial respiratory chain complex IV assembly + D-galactonate catabolic process + carbohydrate transmembrane transport + microtubule anchoring + U6 snRNA 3'-end processing + histone lysine methylation + gluconate transmembrane transport + regulation of protein catabolic process + vitamin B6 biosynthetic process + pyridoxal phosphate biosynthetic process + ATP-dependent chromatin remodeling + purine-containing compound salvage + negative regulation of cysteine-type endopeptidase activity involved in apoptotic process + regulation of ATPase activity + benzoate catabolic process + cellular carbohydrate metabolic process + sodium-dependent phosphate transport + [2Fe-2S] cluster assembly + protein neddylation + regulation of angiogenesis + xanthine metabolic process + glycolate biosynthetic process + L-arabinose metabolic process + viral entry into host cell + viral procapsid maturation + replication fork protection + protein stabilization + regulation of sequence-specific DNA binding transcription factor activity + protein oligomerization + kinetochore assembly + regulation of cell cycle + vacuolar proton-transporting V-type ATPase complex assembly + tRNA seleno-modification + DNA-templated transcriptional preinitiation complex assembly + 'de novo' L-methionine biosynthetic process + urea transmembrane transport + conversion of methionyl-tRNA to N-formyl-methionyl-tRNA + mRNA methylation + selenocysteinyl-tRNA(Sec) biosynthetic process + negative regulation of bacterial-type flagellum assembly + mitotic recombination-dependent replication fork processing + membrane + integral component of membrane + cytoplasm + intracellular + ribosome + nucleus + myosin complex + outer membrane-bounded periplasmic space + Golgi membrane + dynein complex + extracellular region + small ribosomal subunit + large ribosomal subunit + chromosome + outer membrane + photosystem II + proteasome core complex + nucleosome + plasma membrane + ATP-binding cassette (ABC) transporter complex + endoplasmic reticulum + membrane coat + proton-transporting ATP synthase complex, catalytic core F(1) + proton-transporting ATP synthase complex, coupling factor F(o) + microtubule + voltage-gated potassium channel complex + photosystem I + clathrin adaptor complex + integral component of plasma membrane + photosystem II oxygen evolving complex + kinesin complex + intracellular ribonucleoprotein complex + proton-transporting two-sector ATPase complex, proton-transporting domain + nuclear pore + glycerol-3-phosphate dehydrogenase complex + extrinsic component of membrane + COPII vesicle coat + small-subunit processome + cell outer membrane + acetyl-CoA carboxylase complex + proton-transporting V-type ATPase, V0 domain + signal recognition particle + 1,3-beta-D-glucan synthase complex + transcription factor complex + microtubule organizing center + beta-galactosidase complex + type II protein secretion system complex + mediator complex + phosphopyruvate hydratase complex + spindle pole + mitochondrial inner membrane + HslUV protease complex + chloroplast + photosystem I reaction center + proteasome core complex, alpha-subunit complex + MCM complex + periplasmic space + spliceosomal complex + nucleolus + mitochondrion + integral component of peroxisomal membrane + endoplasmic reticulum membrane + eukaryotic translation initiation factor 3 complex + Arp2/3 protein complex + DNA polymerase III complex + Golgi transport complex + viral capsid + MKS complex + thylakoid membrane + cytochrome complex + ubiquitin ligase complex + core TFIIH complex + chromosome, centromeric region + cytosol + exodeoxyribonuclease VII complex + excinuclease repair complex + photosystem II reaction center + actin cytoskeleton + molybdopterin synthase complex + COPI vesicle coat + retromer complex + proton-transporting V-type ATPase, V1 domain + BBSome + intracellular membrane-bounded organelle + WASH complex + protein phosphatase type 2A complex + origin recognition complex + extracellular space + cell wall + mitochondrial outer membrane + signal peptidase complex + voltage-gated calcium channel complex + protein kinase CK2 complex + glycine cleavage complex + F-actin capping protein complex + peptidoglycan-based cell wall + 3-isopropylmalate dehydratase complex + riboflavin synthase complex + cytochrome b6f complex + thylakoid + prefoldin complex + clathrin coat of trans-Golgi network vesicle + clathrin coat of coated pit + GPI-anchor transamidase complex + oxoglutarate dehydrogenase complex + pyruvate dehydrogenase complex + nuclear chromosome + condensin complex + DNA replication factor C complex + DNA-directed RNA polymerase III complex + transcription factor TFIID complex + anaphase-promoting complex + mitochondrial respiratory chain complex III + mitochondrial ribosome + peroxisome + signal recognition particle, endoplasmic reticulum targeting + proteasome activator complex + formate dehydrogenase complex + polyphosphate kinase complex + Holliday junction helicase complex + bacterial-type flagellum basal body, distal rod, L ring + bacterial-type flagellum basal body, distal rod, P ring + bacterial-type flagellum basal body, MS ring + photosystem + Cdc73/Paf1 complex + TRAPP complex + checkpoint clamp complex + extracellular matrix + Ctf18 RFC-like complex + motile cilium + tRNA (m1A) methyltransferase complex + tricarboxylic acid cycle enzyme complex + succinate dehydrogenase complex + histone acetyltransferase complex + exocyst + ribonuclease MRP complex + nuclear exosome (RNase complex) + vacuolar proton-transporting V-type ATPase, V1 domain + mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) + mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) + THO complex part of transcription export complex + proteasome complex + gamma-tubulin complex + proteinaceous extracellular matrix + nuclear origin of replication recognition complex + DNA-directed RNA polymerase II, core complex + transcription factor TFIIA complex + transcription factor TFIIF complex + U1 snRNP + small nucleolar ribonucleoprotein complex + mitochondrial envelope + mitochondrial outer membrane translocase complex + mitochondrial inner membrane presequence translocase complex + mitochondrial respiratory chain complex IV + mitochondrial intermembrane space + mitochondrial matrix + signal recognition particle receptor complex + endoplasmic reticulum lumen + Golgi apparatus + fatty acid synthase complex + cytoskeleton + microtubule associated complex + gamma-tubulin ring complex + Gram-negative-bacterium-type cell wall + bacterial-type flagellum hook + bacterial-type flagellum basal body, distal rod + vacuolar proton-transporting V-type ATPase complex + viral envelope + CCR4-NOT complex + integral component of Golgi membrane + integral component of endoplasmic reticulum membrane + protein phosphatase 4 complex + ribonuclease P complex + preribosome, small subunit precursor + bacterial-type flagellum basal body, rod + Smc5-Smc6 complex + glutamyl-tRNA(Gln) amidotransferase complex + intraciliary transport particle A + BLOC-1 complex + Sec62/Sec63 complex + integral component of thylakoid membrane + cullin-RING ubiquitin ligase complex + ribonuclease H2 complex + SMN complex + proton-transporting two-sector ATPase complex, catalytic domain + Mpp10 complex + SMN-Sm protein complex + SAGA-type complex + FANCM-MHF complex + Ragulator complex + U2AF + ATG1/ULK1 kinase complex + CST complex + protein binding + ATP binding + catalytic activity + oxidoreductase activity + calcium ion binding + nucleic acid binding + DNA binding + protein kinase activity + hydrolase activity + zinc ion binding + RNA binding + structural constituent of ribosome + ATPase activity + transcription factor activity, sequence-specific DNA binding + GTP binding + transporter activity + ion channel activity + methyltransferase activity + metal ion binding + flavin adenine dinucleotide binding + microtubule motor activity + nucleotide binding + hydrolase activity, hydrolyzing O-glycosyl compounds + microtubule binding + pyridoxal phosphate binding + transferase activity, transferring glycosyl groups + ubiquitin-protein transferase activity + GTPase activity + electron carrier activity + heme binding + serine-type endopeptidase activity + aminoacyl-tRNA ligase activity + N-acetyltransferase activity + oxidoreductase activity, acting on the CH-CH group of donors + NAD binding + iron-sulfur cluster binding + iron ion binding + magnesium ion binding + metalloendopeptidase activity + sequence-specific DNA binding + NAD+ ADP-ribosyltransferase activity + transferase activity + 2 iron, 2 sulfur cluster binding + peptidyl-prolyl cis-trans isomerase activity + serine-type peptidase activity + pseudouridine synthase activity + transferase activity, transferring acyl groups other than amino-acyl groups + motor activity + hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds + phosphatidylinositol binding + ATPase activity, coupled to transmembrane movement of substances + DNA-directed 5'-3' RNA polymerase activity + metallopeptidase activity + transferase activity, transferring phosphorus-containing groups + kinase activity + voltage-gated potassium channel activity + oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + peptidase activity + FMN binding + oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + transferase activity, transferring acyl groups + lyase activity + transaminase activity + thiol-dependent ubiquitinyl hydrolase activity + 4 iron, 4 sulfur cluster binding + FAD binding + aspartic-type endopeptidase activity + receptor activity + coenzyme binding + ice binding + NAD(P)+-protein-arginine ADP-ribosyltransferase activity + NADP binding + cysteine-type peptidase activity + protein dimerization activity + RNA methyltransferase activity + unfolded protein binding + protein tyrosine/serine/threonine phosphatase activity + cation transmembrane transporter activity + 3'-5' exonuclease activity + sulfuric ester hydrolase activity + nucleotidyltransferase activity + hydrolase activity, acting on ester bonds + protein tyrosine phosphatase activity + phosphoric diester hydrolase activity + cofactor binding + nuclease activity + NADH dehydrogenase (ubiquinone) activity + protein disulfide oxidoreductase activity + isomerase activity + sugar:proton symporter activity + phosphorelay sensor kinase activity + transmembrane transporter activity + endonuclease activity + galactosyltransferase activity + transferase activity, transferring alkyl or aryl (other than methyl) groups + magnesium ion transmembrane transporter activity + solute:proton antiporter activity + carbohydrate binding + structural molecule activity + copper ion binding + translation initiation factor activity + DNA-directed DNA polymerase activity + calcium-dependent cysteine-type endopeptidase activity + phosphorus-oxygen lyase activity + nucleobase-containing compound kinase activity + acyl-CoA dehydrogenase activity + cytochrome-c oxidase activity + potassium channel activity + sulfotransferase activity + hydrogen ion transmembrane transporter activity + RNA polymerase II transcription factor activity, sequence-specific DNA binding + DNA helicase activity + damaged DNA binding + helicase activity + protein transporter activity + rRNA binding + 3-hydroxyacyl-CoA dehydrogenase activity + small protein activating enzyme activity + drug transmembrane transporter activity + antiporter activity + tRNA dihydrouridine synthase activity + translation elongation factor activity + peptide-methionine (S)-S-oxide reductase activity + oxidoreductase activity, acting on NAD(P)H + sigma factor activity + mismatched DNA binding + metal ion transmembrane transporter activity + aminopeptidase activity + transposase activity + phosphotransferase activity, alcohol group as acceptor + ligase activity, forming aminoacyl-tRNA and related compounds + threonine-type endopeptidase activity + GTPase activator activity + N-methyltransferase activity + ammonium transmembrane transporter activity + oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + serine-type carboxypeptidase activity + sialyltransferase activity + proton-transporting ATP synthase activity, rotational mechanism + actin binding + DNA topoisomerase type II (ATP-hydrolyzing) activity + protein serine/threonine kinase activity + signal transducer activity + sulfate transmembrane transporter activity + intramolecular transferase activity, phosphotransferases + tRNA binding + 3',5'-cyclic-nucleotide phosphodiesterase activity + extracellular ligand-gated ion channel activity + transferase activity, transferring pentosyl groups + phosphatase activity + manganese ion binding + peptide-methionine (R)-S-oxide reductase activity + metallocarboxypeptidase activity + phosphogluconate dehydrogenase (decarboxylating) activity + intramolecular transferase activity + NAD+ binding + DNA topoisomerase activity + acetyl-CoA carboxylase activity + thiol-dependent ubiquitin-specific protease activity + oxidoreductase activity, acting on CH-OH group of donors + transferase activity, transferring hexosyl groups + ligase activity + histone-lysine N-methyltransferase activity + chaperone binding + DNA ligase (ATP) activity + adenylate kinase activity + monooxygenase activity + ATP-dependent helicase activity + amino acid transmembrane transporter activity + molybdenum ion binding + cation binding + translation release factor activity + mannosyl-oligosaccharide 1,2-alpha-mannosidase activity + antioxidant activity + oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor + oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor + nucleoside-triphosphate diphosphatase activity + recombinase activity + glucose-6-phosphate dehydrogenase activity + glutathione peroxidase activity + phosphoglycerate mutase activity + tRNA (guanine-N7-)-methyltransferase activity + metalloexopeptidase activity + CoA-transferase activity + fatty-acyl-CoA binding + aminoacyl-tRNA editing activity + acid phosphatase activity + carbonate dehydratase activity + MAP kinase activity + calcium-dependent phospholipid binding + acetylglucosaminyltransferase activity + nickel cation binding + phosphatidylinositol phosphate kinase activity + phosphotransferase activity, phosphate group as acceptor + dipeptidase activity + racemase and epimerase activity, acting on carbohydrates and derivatives + thiamine pyrophosphate binding + intermembrane lipid transfer activity + glutamate-ammonia ligase activity + penicillin binding + oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + phosphotransferase activity, for other substituted phosphate groups + hydrolase activity, hydrolyzing N-glycosyl compounds + nitronate monooxygenase activity + substrate-specific transmembrane transporter activity + ATP-dependent DNA helicase activity + endopeptidase activity + superoxide dismutase activity + hydrolase activity, acting on glycosyl bonds + cobalamin binding + transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer + mannosyltransferase activity + DNA-(apurinic or apyrimidinic site) lyase activity + ATP-dependent peptidase activity + inorganic diphosphatase activity + pyruvate kinase activity + scavenger receptor activity + 7S RNA binding + Ran GTPase binding + rRNA methyltransferase activity + oxidoreductase activity, acting on the CH-NH2 group of donors + hydroxymethyl-, formyl- and related transferase activity + potassium ion binding + glutathione hydrolase activity + quinone binding + ATPase activator activity + NAD+ kinase activity + coproporphyrinogen oxidase activity + glutathione synthase activity + RNA-DNA hybrid ribonuclease activity + exonuclease activity + nucleoside diphosphate kinase activity + glycine-tRNA ligase activity + phenylalanine-tRNA ligase activity + ARF guanyl-nucleotide exchange factor activity + Rho guanyl-nucleotide exchange factor activity + structural constituent of cell wall + inorganic phosphate transmembrane transporter activity + ferric iron binding + inositol-1,4,5-trisphosphate 3-kinase activity + S-adenosylmethionine-dependent methyltransferase activity + molybdate ion transmembrane transporter activity + hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides + deaminase activity + double-stranded DNA binding + single-stranded DNA binding + 3-hydroxyisobutyryl-CoA hydrolase activity + 6-phosphofructo-2-kinase activity + DNA primase activity + DNA topoisomerase type I activity + RNA-directed 5'-3' RNA polymerase activity + aminoacyl-tRNA hydrolase activity + peroxidase activity + phosphoglycerate kinase activity + triose-phosphate isomerase activity + valine-tRNA ligase activity + transcription factor binding + heme-copper terminal oxidase activity + heme transporter activity + glutamate synthase activity + hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances + ribosome binding + peroxiredoxin activity + uridylyltransferase activity + RNA polymerase II transcription cofactor activity + chromatin binding + 1,3-beta-D-glucan synthase activity + 3-deoxy-7-phosphoheptulonate synthase activity + N-acetyl-gamma-glutamyl-phosphate reductase activity + UDP-glucose 4-epimerase activity + ferrochelatase activity + fructose-bisphosphate aldolase activity + hydroxymethylbilane synthase activity + malate synthase activity + methylenetetrahydrofolate reductase (NAD(P)H) activity + ribonuclease activity + beta-galactosidase activity + ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor + arginine-tRNA ligase activity + isoleucine-tRNA ligase activity + uroporphyrinogen decarboxylase activity + voltage-gated chloride channel activity + lipid binding + fucosyltransferase activity + sodium:proton antiporter activity + P-P-bond-hydrolysis-driven protein transmembrane transporter activity + amino acid binding + carboxyl- or carbamoyltransferase activity + hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + carboxy-lyase activity + carbon-sulfur lyase activity + ubiquitin protein ligase binding + ribonuclease T2 activity + protein homodimerization activity + serine-type exopeptidase activity + carbohydrate derivative binding + adenyl-nucleotide exchange factor activity + 1-alkyl-2-acetylglycerophosphocholine esterase activity + DNA ligase activity + catalase activity + glycerol-3-phosphate dehydrogenase [NAD+] activity + histone acetyltransferase activity + ribonuclease III activity + alpha-mannosidase activity + beta-N-acetylhexosaminidase activity + pantothenate kinase activity + phosphopyruvate hydratase activity + phosphoribosylamine-glycine ligase activity + thiosulfate sulfurtransferase activity + alanine-tRNA ligase activity + structural constituent of cytoskeleton + calcium:sodium antiporter activity + ATP:ADP antiporter activity + SNAP receptor activity + sarcosine oxidase activity + ferrous iron binding + 5'-nucleotidase activity + holo-[acyl-carrier-protein] synthase activity + excinuclease ABC activity + chromate transmembrane transporter activity + oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen + sulfurtransferase activity + hydro-lyase activity + protein kinase binding + fructose 1,6-bisphosphate 1-phosphatase activity + peptidoglycan binding + gamma-tubulin binding + actin filament binding + transcription cofactor activity + protein disulfide isomerase activity + 3-beta-hydroxy-delta5-steroid dehydrogenase activity + ATP phosphoribosyltransferase activity + CTP synthase activity + DNA ligase (NAD+) activity + IMP cyclohydrolase activity + adenylosuccinate synthase activity + aspartate kinase activity + dephospho-CoA kinase activity + diacylglycerol O-acyltransferase activity + tetrahydrofolylpolyglutamate synthase activity + glycerol-3-phosphate dehydrogenase activity + guanylate kinase activity + histone deacetylase activity + homogentisate 1,2-dioxygenase activity + indole-3-glycerol-phosphate synthase activity + malate dehydrogenase (decarboxylating) (NAD+) activity + methylenetetrahydrofolate dehydrogenase (NADP+) activity + orotidine-5'-phosphate decarboxylase activity + phosphoenolpyruvate carboxykinase activity + phosphoenolpyruvate carboxykinase (ATP) activity + phosphoribosylaminoimidazolecarboxamide formyltransferase activity + poly(ADP-ribose) glycohydrolase activity + ribose-5-phosphate isomerase activity + tRNA (guanine-N2-)-methyltransferase activity + methionine-tRNA ligase activity + galactose binding + O-methyltransferase activity + dipeptidyl-peptidase activity + 3,4-dihydroxy-2-butanone-4-phosphate synthase activity + methionine synthase activity + exodeoxyribonuclease VII activity + alternative oxidase activity + chlorophyllide a oxygenase [overall] activity + ion transmembrane transporter activity + symporter activity + site-specific DNA-methyltransferase (cytosine-N4-specific) activity + translation release factor activity, codon specific + oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor + hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + hydrolase activity, acting on acid anhydrides + endodeoxyribonuclease activity, producing 5'-phosphomonoesters + purine nucleotide binding + cation-transporting ATPase activity + enzyme regulator activity + phosphoric ester hydrolase activity + ADP binding + electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity + IMP 5'-nucleotidase activity + ADP-dependent NAD(P)H-hydrate dehydratase activity + 3'-5'-exoribonuclease activity + rRNA (adenine-N6,N6-)-dimethyltransferase activity + DNA replication origin binding + transcription corepressor activity + double-stranded RNA binding + lysozyme activity + beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity + 2-isopropylmalate synthase activity + 3-dehydroquinate dehydratase activity + 3-dehydroquinate synthase activity + 3-isopropylmalate dehydratase activity + 6-phosphofructokinase activity + GMP synthase (glutamine-hydrolyzing) activity + UDP-glucose:glycoprotein glucosyltransferase activity + acetolactate synthase activity + acetate-CoA ligase activity + adenosylhomocysteinase activity + aspartate carbamoyltransferase activity + branched-chain-amino-acid transaminase activity + carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity + dihydrolipoyl dehydrogenase activity + 3-oxoacyl-[acyl-carrier-protein] synthase activity + galactokinase activity + glucokinase activity + glucose-6-phosphate isomerase activity + glucosylceramidase activity + glutamate N-acetyltransferase activity + glycine dehydrogenase (decarboxylating) activity + heme oxygenase (decyclizing) activity + histidinol dehydrogenase activity + hydroxymethylglutaryl-CoA reductase (NADPH) activity + methylmalonyl-CoA mutase activity + N,N-dimethylaniline monooxygenase activity + phosphoribosylaminoimidazolesuccinocarboxamide synthase activity + phosphoribosylanthranilate isomerase activity + phosphoribosylformylglycinamidine synthase activity + polygalacturonase activity + porphobilinogen synthase activity + prephenate dehydratase activity + protein histidine kinase activity + ribose phosphate diphosphokinase activity + shikimate 3-dehydrogenase (NADP+) activity + sulfate adenylyltransferase (ATP) activity + thioredoxin-disulfide reductase activity + L-threonine ammonia-lyase activity + thymidine kinase activity + glutamate-tRNA ligase activity + leucine-tRNA ligase activity + lysine-tRNA ligase activity + proline-tRNA ligase activity + serine-tRNA ligase activity + threonine-tRNA ligase activity + tryptophan-tRNA ligase activity + tryptophan synthase activity + uracil DNA N-glycosylase activity + uroporphyrinogen-III synthase activity + calcium channel activity + binding + 5S rRNA binding + UDP-glucose:hexose-1-phosphate uridylyltransferase activity + ubiquinol-cytochrome-c reductase activity + 3-hydroxyisobutyrate dehydrogenase activity + riboflavin kinase activity + potassium-transporting ATPase activity + 1-deoxy-D-xylulose-5-phosphate synthase activity + 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity + 5-amino-6-(5-phosphoribosylamino)uracil reductase activity + diaminopimelate decarboxylase activity + diaminopimelate epimerase activity + 4-hydroxy-tetrahydrodipicolinate reductase + formate dehydrogenase (NAD+) activity + [glutamate-ammonia-ligase] adenylyltransferase activity + leucyltransferase activity + lipid-A-disaccharide synthase activity + phospho-N-acetylmuramoyl-pentapeptide-transferase activity + polyphosphate kinase activity + four-way junction helicase activity + potassium ion transmembrane transporter activity + AMP binding + acetyltransferase activity + octanoyltransferase activity + oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors + glutathione gamma-glutamylcysteinyltransferase activity + hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines + aldehyde-lyase activity + acid-amino acid ligase activity + thiol oxidase activity + S-formylglutathione hydrolase activity + guanyl nucleotide binding + protein phosphatase regulator activity + polysaccharide binding + thiamine binding + cysteine desulfurase activity + G-protein beta/gamma-subunit complex binding + ubiquitin-ubiquitin ligase activity + identical protein binding + ATP-dependent 3'-5' DNA helicase activity + nutrient reservoir activity + violaxanthin de-epoxidase activity + oleate hydratase activity + S-(hydroxymethyl)glutathione dehydrogenase activity + NADPH binding + starch binding + succinate dehydrogenase activity + imidazoleglycerol-phosphate synthase activity + purinergic nucleotide receptor activity + mRNA binding + gamma-glutamylcyclotransferase activity + 1-pyrroline-5-carboxylate dehydrogenase activity + 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity + 3-methyl-2-oxobutanoate hydroxymethyltransferase activity + 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity + acetylglutamate kinase activity + adenylylsulfate kinase activity + amidophosphoribosyltransferase activity + argininosuccinate synthase activity + argininosuccinate lyase activity + arginyltransferase activity + aspartate-semialdehyde dehydrogenase activity + biotin synthase activity + chorismate synthase activity + citrate (Si)-synthase activity + cytidylate kinase activity + dihydrolipoyllysine-residue succinyltransferase activity + dihydroneopterin aldolase activity + 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity + fumarylacetoacetase activity + glutamate dehydrogenase (NAD+) activity + glutamate-cysteine ligase activity + glycerone kinase activity + glycylpeptide N-tetradecanoyltransferase activity + histidinol-phosphate transaminase activity + homoserine kinase activity + hydroxyacylglutathione hydrolase activity + hydroxymethylglutaryl-CoA synthase activity + imidazoleglycerol-phosphate dehydratase activity + phosphatidylinositol phospholipase C activity + isocitrate dehydrogenase (NADP+) activity + isocitrate lyase activity + ketol-acid reductoisomerase activity + methionine adenosyltransferase activity + endodeoxyribonuclease activity + alpha,alpha-trehalase activity + alpha-galactosidase activity + oligosaccharyl transferase activity + oxoglutarate dehydrogenase (succinyl-transferring) activity + pantoate-beta-alanine ligase activity + phosphatidylserine decarboxylase activity + phosphoribosyl-AMP cyclohydrolase activity + phosphoribosyl-ATP diphosphatase activity + phosphoserine phosphatase activity + O-phospho-L-serine:2-oxoglutarate aminotransferase activity + protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity + pyrroline-5-carboxylate reductase activity + pyruvate dehydrogenase (acetyl-transferring) activity + dihydrolipoyllysine-residue acetyltransferase activity + thiamine diphosphokinase activity + thiamine-phosphate diphosphorylase activity + thymidylate kinase activity + thymidylate synthase activity + triglyceride lipase activity + cysteine-tRNA ligase activity + histidine-tRNA ligase activity + tyrosine-tRNA ligase activity + tryptophan 2,3-dioxygenase activity + ureidoglycolate hydrolase activity + extracellular ATP-gated cation channel activity + GDP-dissociation inhibitor activity + inward rectifier potassium channel activity + voltage-gated calcium channel activity + copper ion transmembrane transporter activity + phospholipid binding + DNA-dependent ATPase activity + galactoside 2-alpha-L-fucosyltransferase activity + 4-alpha-hydroxytetrahydrobiopterin dehydratase activity + tRNA methyltransferase activity + protein methyltransferase activity + calcium- and calmodulin-responsive adenylate cyclase activity + 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity + CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity + GDP-mannose 4,6-dehydratase activity + RNA ligase activity + queuine tRNA-ribosyltransferase activity + protoheme IX farnesyltransferase activity + acetyl-CoA transporter activity + DNA-3-methyladenine glycosylase activity + N-acetylmuramoyl-L-alanine amidase activity + UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity + UDP-N-acetylmuramate dehydrogenase activity + cellulase activity + dTDP-4-dehydrorhamnose 3,5-epimerase activity + 4-hydroxy-tetrahydrodipicolinate synthase + inositol monophosphate 1-phosphatase activity + phosphomethylpyrimidine kinase activity + Type I site-specific deoxyribonuclease activity + hydrogen-translocating pyrophosphatase activity + polysaccharide transmembrane transporter activity + peptide transporter activity + N-acyltransferase activity + pyrophosphatase activity + glutaminyl-peptide cyclotransferase activity + oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + magnesium chelatase activity + ligase activity, forming carbon-nitrogen bonds + phosphatase activator activity + protein kinase regulator activity + protein domain specific binding + 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity + heat shock protein binding + lipoyl(octanoyl) transferase activity + DNA polymerase activity + racemase activity, acting on amino acids and derivatives + 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity + alpha-L-arabinofuranosidase activity + transition metal ion binding + ER retention sequence binding + proton-transporting ATPase activity, rotational mechanism + undecaprenyl-diphosphatase activity + 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity + cobalt ion binding + 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity + serine-type aminopeptidase activity + cytidylyltransferase activity + palmitoyl hydrolase activity + phosphorelay response regulator activity + tRNA-intron endonuclease activity + alanine dehydrogenase activity + 6,7-dimethyl-8-ribityllumazine synthase activity + DNA clamp loader activity + 3-hydroxybutyrate dehydrogenase activity + 3-isopropylmalate dehydrogenase activity + 3-phosphoshikimate 1-carboxyvinyltransferase activity + 4-hydroxyphenylpyruvate dioxygenase activity + 5-aminolevulinate synthase activity + D-arabinono-1,4-lactone oxidase activity + methylated-DNA-[protein]-cysteine S-methyltransferase activity + FMN adenylyltransferase activity + GTP cyclohydrolase I activity + GTP cyclohydrolase II activity + IMP dehydrogenase activity + NAD+ synthase (glutamine-hydrolyzing) activity + UDP-N-acetylglucosamine diphosphorylase activity + aconitate hydratase activity + adenosine deaminase activity + phospholipid-translocating ATPase activity + adenosylmethionine decarboxylase activity + N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity + aminomethyltransferase activity + arylformamidase activity + biotin-[acetyl-CoA-carboxylase] ligase activity + cholinesterase activity + cystathionine beta-lyase activity + cysteine synthase activity + cytidine deaminase activity + diacylglycerol kinase activity + dihydrofolate reductase activity + dihydroorotase activity + dihydroorotate dehydrogenase activity + dihydroxy-acid dehydratase activity + dUTP diphosphatase activity + formate-tetrahydrofolate ligase activity + fumarate hydratase activity + glutaminase activity + glutamine-fructose-6-phosphate transaminase (isomerizing) activity + histidinol-phosphatase activity + holocytochrome-c synthase activity + isopentenyl-diphosphate delta-isomerase activity + phosphogluconate dehydratase activity + lactoylglutathione lyase activity + mannose-6-phosphate isomerase activity + mRNA guanylyltransferase activity + methylmalonate-semialdehyde dehydrogenase (acylating) activity + inositol-3-phosphate synthase activity + nicotinate-nucleotide diphosphorylase (carboxylating) activity + nitric-oxide synthase activity + ribonuclease P activity + deoxyribonuclease activity + alpha-L-fucosidase activity + dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity + orotate phosphoribosyltransferase activity + pantetheine-phosphate adenylyltransferase activity + phosphoglycerate dehydrogenase activity + phosphoribosylformylglycinamidine cyclo-ligase activity + phosphoribosylglycinamide formyltransferase activity + polynucleotide adenylyltransferase activity + prenyltransferase activity + prephenate dehydrogenase (NADP+) activity + protein-arginine deiminase activity + calmodulin-dependent protein kinase activity + protein-L-isoaspartate (D-aspartate) O-methyltransferase activity + pyridoxamine-phosphate oxidase activity + ribokinase activity + transketolase activity + protein phosphatase inhibitor activity + endopeptidase inhibitor activity + signal recognition particle binding + guanyl-nucleotide exchange factor activity + Rab GDP-dissociation inhibitor activity + hormone activity + iron ion transmembrane transporter activity + monovalent cation:proton antiporter activity + calmodulin binding + chitin binding + tRNA-specific adenosine deaminase activity + protein prenyltransferase activity + pyridoxal kinase activity + gamma-glutamyl carboxylase activity + oxidized purine nucleobase lesion DNA N-glycosylase activity + 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity + 2-dehydropantoate 2-reductase activity + 4-hydroxy-2-oxovalerate aldolase activity + AMP nucleosidase activity + D-alanine-D-alanine ligase activity + UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity + UDP-N-acetylglucosamine 2-epimerase activity + UDP-N-acetylmuramate-L-alanine ligase activity + UDP-N-acetylmuramoylalanine-D-glutamate ligase activity + UDP-galactopyranose mutase activity + acetaldehyde dehydrogenase (acetylating) activity + alanine racemase activity + arsenate reductase (glutaredoxin) activity + beta-lactamase activity + cobalamin 5'-phosphate synthase activity + crossover junction endodeoxyribonuclease activity + dCTP deaminase activity + formyltetrahydrofolate deformylase activity + guanine deaminase activity + malate dehydrogenase (quinone) activity + nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity + prephenate dehydrogenase (NAD+) activity + serine O-acetyltransferase activity + serine-type D-Ala-D-Ala carboxypeptidase activity + tRNA nucleotidyltransferase activity + tetraacyldisaccharide 4'-kinase activity + urease activity + blue light photoreceptor activity + galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity + calcium:proton antiporter activity + p-aminobenzoyl-glutamate uptake transmembrane transporter activity + 2-keto-3-deoxygluconate:proton symporter activity + alanine:sodium symporter activity + chlorophyll binding + tRNA (cytosine-5-)-methyltransferase activity + rRNA (adenine) methyltransferase activity + malate dehydrogenase activity + protochlorophyllide reductase activity + oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor + oxidoreductase activity, acting on single donors with incorporation of molecular oxygen + oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen + oxidoreductase activity, oxidizing metal ions + transferase activity, transferring selenium-containing groups + triphosphoric monoester hydrolase activity + oxo-acid-lyase activity + carbon-nitrogen ligase activity, with glutamine as amido-N-donor + lipoate synthase activity + 6-phosphogluconolactonase activity + acetoacetyl-CoA reductase activity + protocatechuate 3,4-dioxygenase activity + glucosamine-1-phosphate N-acetyltransferase activity + tubulin N-acetyltransferase activity + cellulose binding + kynureninase activity + U5 snRNA binding + endoplasmic reticulum signal peptide binding + protein complex scaffold activity + pyridoxine 5'-phosphate synthase activity + inositol pentakisphosphate 2-kinase activity + cyclic-di-GMP binding + phosphate ion binding + histone binding + lipoprotein transporter activity + precorrin-2 dehydrogenase activity + molybdopterin cofactor binding + acyl-phosphate glycerol-3-phosphate acyltransferase activity + macromolecular complex binding + chalcone isomerase activity + UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity + chlorophyllase activity + inositol oxygenase activity + N-carbamoylputrescine amidase activity + ureidoglycolate lyase activity + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity + thymidylate synthase (FAD) activity + adenosylcobinamide-GDP ribazoletransferase activity + D-aminoacyl-tRNA deacylase activity + tRNA (guanine(37)-N(1))-methyltransferase activity + peptidase activity, acting on L-amino acid peptides + Lys48-specific deubiquitinase activity + 3-hydroxyanthranilate 3,4-dioxygenase activity + RNA 7-methylguanosine cap binding + RNA polymerase II transcription corepressor activity + galactosylceramide sulfotransferase activity + nucleoside binding + transcription coactivator activity + 1-acylglycerol-3-phosphate O-acyltransferase activity + 4-aminobutyrate transaminase activity + 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity + deoxyribodipyrimidine photo-lyase activity + alkylbase DNA N-glycosylase activity + DNA photolyase activity + GTP cyclohydrolase activity + L-serine ammonia-lyase activity + NADH dehydrogenase activity + UTP:glucose-1-phosphate uridylyltransferase activity + adenosine kinase activity + ATP-dependent RNA helicase activity + allantoicase activity + anthranilate phosphoribosyltransferase activity + anthranilate synthase activity + arginase activity + asparagine synthase (glutamine-hydrolyzing) activity + chorismate mutase activity + cyclic-nucleotide phosphodiesterase activity + cystathionine beta-synthase activity + L-seryl-tRNASec selenium transferase activity + 4-alpha-glucanotransferase activity + deoxyribose-phosphate aldolase activity + dihydropteroate synthase activity + dimethylallyltranstransferase activity + diphosphomevalonate decarboxylase activity + diphthine synthase activity + cysteine-type endopeptidase activity + fatty acid synthase activity + [acyl-carrier-protein] S-malonyltransferase activity + galactosylceramidase activity + glucosamine-6-phosphate deaminase activity + glutamate 5-kinase activity + glutamate-5-semialdehyde dehydrogenase activity + glutathione-disulfide reductase activity + hypoxanthine phosphoribosyltransferase activity + malic enzyme activity + methionyl-tRNA formyltransferase activity + mevalonate kinase activity + phenylalanine 4-monooxygenase activity + deoxyribonuclease II activity + dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity + phosphoadenylyl-sulfate reductase (thioredoxin) activity + phosphatidate cytidylyltransferase activity + phosphomannomutase activity + phosphoribosylaminoimidazole carboxylase activity + phosphorylase activity + polynucleotide 5'-phosphatase activity + polyribonucleotide nucleotidyltransferase activity + DNA-dependent protein kinase activity + phosphoprotein phosphatase activity + oxygen-dependent protoporphyrinogen oxidase activity + thyroxine 5'-deiodinase activity + aspartate-tRNA ligase activity + asparagine-tRNA ligase activity + uracil phosphoribosyltransferase activity + G-protein coupled receptor activity + histamine receptor activity + Rho GDP-dissociation inhibitor activity + cytokine activity + lipid transporter activity + neurotransmitter:sodium symporter activity + nucleoside transmembrane transporter activity + galactose transmembrane transporter activity + glucose transmembrane transporter activity + folic acid binding + beta-catenin binding + enzyme activator activity + primary amine oxidase activity + glycogen phosphorylase activity + RNA-dependent ATPase activity + tRNA guanylyltransferase activity + peptidyl-dipeptidase activity + secondary active sulfate transmembrane transporter activity + O-acyltransferase activity + 5'-3' exonuclease activity + 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity + dTDP-glucose 4,6-dehydratase activity + DNA topoisomerase (ATP-hydrolyzing) inhibitor activity + 2-dehydro-3-deoxygalactonokinase activity + 3-deoxy-manno-octulosonate cytidylyltransferase activity + L-aspartate oxidase activity + NAD(P)+ transhydrogenase activity + [protein-PII] uridylyltransferase activity + acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity + adenosylhomocysteine nucleosidase activity + alkyl hydroperoxide reductase activity + arginine N-succinyltransferase activity + choline dehydrogenase activity + cob(I)yrinic acid a,c-diamide adenosyltransferase activity + diaminohydroxyphosphoribosylaminopyrimidine deaminase activity + ethanolamine ammonia-lyase activity + glucose-1-phosphate thymidylyltransferase activity + glutamate racemase activity + glutamyl-tRNA reductase activity + isochorismatase activity + isochorismate synthase activity + mannonate dehydratase activity + methylthioadenosine nucleosidase activity + lytic transglycosylase activity + nitrite reductase [NAD(P)H] activity + phosphatidylglycerophosphatase activity + phosphoenolpyruvate carboxylase activity + phosphoglucosamine mutase activity + phosphoglycolate phosphatase activity + phosphopentomutase activity + phosphoribulokinase activity + protein-N(PI)-phosphohistidine-sugar phosphotransferase activity + protein-glutamate methylesterase activity + quinolinate synthetase A activity + rRNA (guanine-N2-)-methyltransferase activity + succinate-semialdehyde dehydrogenase [NAD(P)+] activity + succinyl-diaminopimelate desuccinylase activity + N-succinylarginine dihydrolase activity + thiamine-phosphate kinase activity + uridylate kinase activity + plastoquinol--plastocyanin reductase activity + L,L-diaminopimelate aminotransferase activity + disulfide oxidoreductase activity + ferrous iron transmembrane transporter activity + gluconate transmembrane transporter activity + carbohydrate transmembrane transporter activity + urea transmembrane transporter activity + sodium-dependent phosphate transmembrane transporter activity + polyamine-transporting ATPase activity + ATPase-coupled sulfate transmembrane transporter activity + toxic substance binding + urocanate hydratase activity + nitrogenase activity + small conductance calcium-activated potassium channel activity + lipase activity + tRNA (adenine-N1-)-methyltransferase activity + copper chaperone activity + cyclin-dependent protein serine/threonine kinase regulator activity + galactonolactone dehydrogenase activity + oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor + oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor + oxidoreductase activity, acting on the CH-NH group of donors + oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor + oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + carotene 7,8-desaturase activity + oxidoreductase activity, acting on iron-sulfur proteins as donors + cellulose synthase (UDP-forming) activity + phosphotransferase activity, carboxyl group as acceptor + thiolester hydrolase activity + ammonia-lyase activity + racemase and epimerase activity, acting on amino acids and derivatives + intramolecular lyase activity + oxidoreductase activity, acting on the aldehyde or oxo group of donors + ribulose-bisphosphate carboxylase activity + precorrin-8X methylmutase activity + precorrin-6A reductase activity + TBP-class protein binding + U6 snRNA binding + nucleoside-diphosphatase activity + phosphatidylinositol N-acetylglucosaminyltransferase activity + catechol 2,3-dioxygenase activity + 4-hydroxybenzoate 3-monooxygenase activity + nitrile hydratase activity + muconate cycloisomerase activity + chloromuconate cycloisomerase activity + DNA N-glycosylase activity + polyamine binding + phosphatase binding + syntaxin binding + protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity + L-malate dehydrogenase activity + DNA polymerase processivity factor activity + snoRNA binding + trans-aconitate 2-methyltransferase activity + translation initiation factor binding + L-ascorbic acid binding + nucleosome binding + choline binding + preQ1 synthase activity + UMP kinase activity + ribonuclease D activity + mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity + hydroxyisourate hydrolase activity + glutamate-1-semialdehyde 2,1-aminomutase activity + adenosylcobinamide kinase activity + coenzyme F420-0 gamma-glutamyl ligase activity + precorrin-6A synthase (deacetylating) activity + tRNA 2-selenouridine synthase activity + acireductone synthase activity + crotonyl-CoA reductase activity + antisigma factor binding + lycopene beta cyclase activity + magnesium protoporphyrin IX methyltransferase activity + oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor + methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity + inositol tetrakisphosphate 1-kinase activity + cholestenol delta-isomerase activity + mRNA 5'-UTR binding + monosaccharide binding + threonine-phosphate decarboxylase activity + beta-tubulin binding + malonyl-CoA decarboxylase activity + pyruvate, phosphate dikinase activity + nitrous-oxide reductase activity + thiaminase activity + undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity + glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity + S-(hydroxymethyl)glutathione synthase activity + inositol-1,3,4-trisphosphate 6-kinase activity + inositol-1,3,4-trisphosphate 5-kinase activity + glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group + 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity + coenzyme F420 binding + nucleotide phosphatase activity, acting on free nucleotides + EF-Hand 1, calcium-binding site + EF-hand domain + Armadillo-like helical + Ankyrin repeat-containing domain + Tetratricopeptide-like helical domain + WD40/YVTN repeat-like-containing domain + Zinc finger, RING/FYVE/PHD-type + Protein kinase domain + Winged helix-turn-helix DNA-binding domain + Alpha/Beta hydrolase fold + Leucine-rich repeat + Immunoglobulin-like fold + Leucine-rich repeat domain, L domain-like + Serine/threonine-protein kinase, active site + Protein kinase, ATP binding site + WD40 repeat + Nucleotide-diphospho-sugar transferases + FAD/NAD(P)-binding domain + Aldolase-type TIM barrel + RmlC-like jelly roll fold + ABC transporter-like + WD40 repeat, conserved site + DnaJ domain + Ribonuclease H-like domain + Ion transport domain + Armadillo + Helicase, C-terminal + Pectin lyase fold + Ankyrin repeat + Short-chain dehydrogenase/reductase SDR + Rossmann-like alpha/beta/alpha sandwich fold + Methyltransferase FkbM + Pyridoxal phosphate-dependent transferase, subdomain 2 + Pyridoxal phosphate-dependent transferase, major region, subdomain 1 + HAD-like domain + Major facilitator superfamily + PH domain-like + DEAD/DEAH box helicase domain + Kinesin motor domain + Metallo-dependent phosphatase-like + Oxoglutarate/iron-dependent dioxygenase + ABC transporter, conserved site + ATPase, AAA-type, core + SAP domain + WW domain + Six-bladed beta-propeller, TolB-like + Galactose-binding domain-like + SET domain + C2 domain + Endonuclease/exonuclease/phosphatase + U box domain + GNAT domain + Histidine kinase-like ATPase, C-terminal domain + Mitochondrial carrier domain + AP2/ERF domain + RNA recognition motif domain + Kelch-type beta propeller + Mitochondrial substrate/solute carrier + Cyclic nucleotide-binding domain + Filamin/ABP280 repeat-like + ShKT domain + FKBP-type peptidyl-prolyl cis-trans isomerase domain + PPM-type phosphatase domain + Leucine rich repeat 5 + Calcineurin-like phosphoesterase domain, ApaH type + G-protein beta WD-40 repeat + Thiolase-like + AMP-dependent synthetase/ligase + Zinc finger, RING-type + Sel1-like repeat + Zinc finger C2H2-type + Small GTP-binding protein domain + Short-chain dehydrogenase/reductase, conserved site + Thioredoxin domain + Histidine phosphatase superfamily + MORN motif + Exostosin-like + Lysine methyltransferase + HSP20-like chaperone + Chlorophyll a/b binding protein domain + ABC transporter type 1, transmembrane domain MetI-like + Nucleotide-diphospho-sugar transferase + Alpha/beta hydrolase fold-1 + IPT domain + SNF2-related, N-terminal domain + Chlorophyll A-B binding protein + NADP-dependent oxidoreductase domain + Chromo domain + Alkaline phosphatase-like, alpha/beta/alpha + EGF-like, conserved site + SANT/Myb domain + Serine-threonine/tyrosine-protein kinase, catalytic domain + Cyclophilin-like domain + PDZ domain + Acyl-CoA dehydrogenase/oxidase, N-terminal + Signal transduction response regulator, receiver domain + Isopenicillin N synthase-like + Protein-tyrosine phosphatase-like + Zinc finger, RING-type, conserved site + Phytanoyl-CoA dioxygenase + von Willebrand factor, type A + Metallo-beta-lactamase + Zinc finger, CCCH-type + Poly(ADP-ribose) polymerase, catalytic domain + Acyl-CoA dehydrogenase/oxidase C-terminal + Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain + Ubiquitin-conjugating enzyme/RWD-like + Ribosomal protein S5 domain 2-type fold, subgroup + Beta-grasp domain + IQ motif, EF-hand binding site + Integrase-like, catalytic domain + Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase + Regulator of chromosome condensation, RCC1 + Aldehyde dehydrogenase domain + Phox homologous domain + Potassium channel domain + Aminotransferase, class I/classII + Histidine phosphatase superfamily, clade-1 + Aldehyde dehydrogenase N-terminal domain + Class I glutamine amidotransferase-like + Toll/interleukin-1 receptor homology (TIR) domain + Myosin head, motor domain + Sugar phosphate transporter domain + Zinc finger, PHD-type, conserved site + ABC transporter type 1, transmembrane domain + FAD dependent oxidoreductase + Glycosyltransferase 61 + NAD(P)-binding domain + Acyl-CoA oxidase/dehydrogenase, central domain + Ubiquitin domain + ATP-grasp fold, subdomain 1 + DnaJ domain, conserved site + CRAL-TRIO lipid binding domain + GTP binding domain + Kinesin motor domain, conserved site + Pleckstrin homology domain + Glutathione S-transferase, N-terminal + Tubulin-tyrosine ligase/Tubulin polyglutamylase + 6-phosphogluconate dehydrogenase, domain 2 + Crotonase superfamily + Sperm-tail PG-rich repeat + Zinc finger, CCHC-type + Ubiquitin-conjugating enzyme E2 + Forkhead-associated (FHA) domain + Pentatricopeptide repeat + UbiB domain + Nucleophile aminohydrolases, N-terminal + Zinc finger, PHD-finger + START-like domain + Tetratricopeptide repeat + Amidohydrolase-related + High mobility group box domain + Reverse transcriptase, RNA-dependent DNA polymerase + Methyltransferase type 11 + NUDIX hydrolase domain + AMP-binding, conserved site + Zinc finger, RanBP2-type + P22 tailspike C-terminal domain-like + PAS domain + GAF domain-like + Amino acid transporter, transmembrane domain + Transcription factor, GTP-binding domain + EamA domain + BTB/POZ domain + Peptidase C19, ubiquitin carboxyl-terminal hydrolase + Aspartic peptidase domain + Pseudouridine synthase, RsuA/RluB/C/D/E/F + DHS-like NAD/FAD-binding domain + Antifreeze protein, type I + PIN domain-like + tRNA (guanine-N1-)-methyltransferase, N-terminal + K Homology domain, type 1 + Small GTPase superfamily + Radical SAM + NAD:arginine ADP-ribosyltransferase, ART + Ubiquitin-associated domain + ATPase, AAA-type, conserved site + TonB-dependent receptor, beta-barrel + Tryptophan synthase beta subunit-like PLP-dependent enzyme + Alcohol dehydrogenase, C-terminal + Ribokinase-like + Rhodanese-like domain + Methyltransferase domain + BRCT domain + OTU domain + Sulfatase, N-terminal + CS domain + ATP-dependent RNA helicase DEAD-box, conserved site + Dual specificity phosphatase, catalytic domain + NAD-dependent epimerase/dehydratase + Aminotransferase class-III + Rieske [2Fe-2S] iron-sulphur domain + Alcohol dehydrogenase, N-terminal + FAD-binding domain + Solute-binding protein family 5 domain + Bestrophin/UPF0187 + Integrase, catalytic core + LysR, substrate-binding + P-type ATPase, cytoplasmic domain N + Cytochrome b5-like heme/steroid binding domain + Thioredoxin, conserved site + AMP-binding enzyme, C-terminal domain + Cytochrome c-like domain + Receptor L-domain + Amine oxidase + Glycosyl transferase, family 8 + Potassium channel, voltage-dependent, EAG/ELK/ERG + TonB-dependent receptor, plug domain + Alpha-ketoglutarate-dependent dioxygenase AlkB-like + Nucleotide-sugar transporter + Signal transduction histidine kinase-related protein, C-terminal + Glycosyltransferase 2-like + WWE domain + Metal-dependent hydrolase, composite domain + Rab-GTPase-TBC domain + Sterile alpha motif domain + Heat shock protein 70 family + Palmitoyltransferase, DHHC domain + Metallopeptidase, catalytic domain + Protein-tyrosine phosphatase, active site + Aldo/keto reductase + Peptidase S8/S53 domain + Major facilitator, sugar transporter-like + Fatty acid desaturase domain + Ribosomal protein L2 domain 2 + ADF-H/Gelsolin-like domain + Oxidoreductase FAD/NAD(P)-binding + P-type ATPase + Homeobox domain + Glycosyltransferase, DXD sugar-binding motif + FMN-binding split barrel + JmjC domain + Aminoacyl-tRNA synthetase, class I, conserved site + Aminoglycoside phosphotransferase + DNA methylase, N-6 adenine-specific, conserved site + Glycosyl transferase, family 31 + Transcription regulator HTH, LysR + Mitochondrial carrier protein + Aminoacyl-tRNA synthetase, class Ia + Cyclic nucleotide-binding, conserved site + Dynein heavy chain domain + Mpv17/PMP22 + Calycin + Sodium/calcium exchanger membrane region + Biotin/lipoyl attachment + Beta-lactamase-related + Cyclin-like + LVIVD + Cation/H+ exchanger + Polycystin cation channel, PKD1/PKD2 + Glutathione S-transferase, C-terminal + RNA-binding S4 domain + ABC transporter, FecCD/TroCD-like + D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain + F-box domain + Peptidase M20 + CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 + Aminoacyl-tRNA synthetase, class Ia, anticodon-binding + Phosphopantetheine binding ACP domain + C-type lectin-like/link domain + 2Fe-2S ferredoxin-type iron-sulfur binding domain + Magnesium transporter NIPA + Histone deacetylase domain + Voltage-dependent L-type calcium channel, IQ-associated domain + tRNA/rRNA methyltransferase, SpoU type + Kelch repeat type 1 + Dynein heavy chain, ATP-binding dynein motor region D5 + PUB domain + NHL repeat + Ubiquitin + Serine aminopeptidase, S33 + Bromodomain + Peptidase C2, calpain, catalytic domain + Adenylyl cyclase class-3/4/guanylyl cyclase + Adenylate kinase/UMP-CMP kinase + CBS domain + Aspartyl/asparaginy/proline hydroxylase + Ubiquitin specific protease, conserved site + SAM-dependent methyltransferase RsmB/NOP2-type + Glycosyl transferase, family 1 + Zinc finger, CXXC-type + Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase + Thiolase, N-terminal + Chromo domain, conserved site + P-type ATPase, phosphorylation site + Beta-ketoacyl synthase, N-terminal + Two pore domain potassium channel + Sugar transporter, conserved site + UVR domain + RNA (C5-cytosine) methyltransferase + TRAM/LAG1/CLN8 homology domain + Fungal lipase-like domain + Signal transduction histidine kinase, dimerisation/phosphoacceptor domain + Zinc finger, MYND-type + Dynein heavy chain, AAA module D4 + Glycosyl hydrolase, five-bladed beta-propellor domain + OmpA-like domain + 3'-5' exonuclease domain + Dynein heavy chain, domain-2 + Dynein heavy chain, hydrolytic ATP-binding dynein motor region D1 + Small GTPase superfamily, ARF/SAR type + Zn(2)-C6 fungal-type DNA-binding domain + Beta-ketoacyl synthase, C-terminal + Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain + Peptidase C1A, papain C-terminal + Tetratricopeptide repeat 2 + Nucleoside diphosphate kinase-like domain + Carbohydrate kinase PfkB + Glyoxalase/fosfomycin resistance/dioxygenase domain + Acyl-CoA dehydrogenase, conserved site + BTB/Kelch-associated + K homology domain-like, alpha/beta + Chaperonin Cpn60/TCP-1 family + Aquaporin-like + Agenet-like domain + Peptidase M16, N-terminal + Flavoprotein-like domain + Multi antimicrobial extrusion protein + THIF-type NAD/FAD binding fold + ABC transporter, permease + EGF-like domain, extracellular + Lipopolysaccharide-modifying protein + Dynein heavy chain, coiled coil stalk + Acriflavin resistance protein + Aminotransferase class V domain + Macrocin-O-methyltransferase + Hexapeptide repeat + tRNA-dihydrouridine synthase + Tr-type G domain, conserved site + CoA-transferase family III domain + CobW/HypB/UreG, nucleotide-binding domain + DNA-binding HTH domain, TetR-type + Peptide methionine sulphoxide reductase MsrA + Cysteine peptidase, cysteine active site + CAP Gly-rich domain + S1 domain + HECT domain + Alpha/beta hydrolase fold-3 + FAS1 domain + Fatty acid hydroxylase + Streptococcal non-M secreted SibA + Heat shock protein 70, conserved site + Thiolase, C-terminal + Peptidase S54, rhomboid domain + PAN/Apple domain + HAD hydrolase, subfamily IA + Adenylate kinase, conserved site + Thioesterase domain + Rubisco LSMT, substrate-binding domain + 3-hydroxyacyl-CoA dehydrogenase, NAD binding + Calponin homology domain + S-adenosyl-L-methionine-dependent methyltransferase + PLP-binding barrel + Galactose oxidase, beta-propeller + FG-GAP repeat + Isoprenoid synthase domain + Polyketide cyclase SnoaL-like domain + GroEL-like equatorial domain + FAD/NAD-linked reductase, dimerisation domain + 4Fe-4S ferredoxin, iron-sulphur binding, conserved site + Zinc finger, CW-type + Glycoside hydrolase-type carbohydrate-binding + Ammonium transporter AmtB-like domain + Helicase-associated domain + Phosphoglycerate/bisphosphoglycerate mutase, active site + NUDIX hydrolase, conserved site + Tubulin/FtsZ, GTPase domain + Crontonase, C-terminal + Dynamin superfamily + CoA-transferase family III + Peptidase S9, prolyl oligopeptidase, catalytic domain + Proteasome, subunit alpha/beta + Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site + Anoctamin + Transmembrane protein TauE-like + Glycoside hydrolase, family 7 + Glycoside hydrolase, family 5 + Glutamine amidotransferase + PLC-like phosphodiesterase, TIM beta/alpha-barrel domain + Glycoside hydrolase, family 3, N-terminal + ABC-2 type transporter + Reverse transcriptase domain + ATPase, dynein-related, AAA domain + Aldehyde dehydrogenase, cysteine active site + Zinc finger, RING-CH-type + Enolase C-terminal domain-like + Leucine-binding protein domain + SGNH hydrolase-type esterase domain + Glycosyl transferase family 29 + CUB domain + Peptidase M20, dimerisation domain + Fumarylacetoacetase, C-terminal-related + Cytochrome P450 + Carbon-nitrogen hydrolase + NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit + Ferritin-related + Peptidase S10, serine carboxypeptidase + Phosphopantetheine attachment site + DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site + Plastid lipid-associated protein/fibrillin conserved domain + Hemolysin-type calcium-binding conserved site + HIT-like domain + VPS9 domain + Pentapeptide repeat + ADP-ribosylation factor-like 2-binding protein, domain + Histone deacetylase superfamily + SNARE associated Golgi protein + Dynein heavy chain, domain-1 + Aspartic peptidase, active site + Transketolase-like, pyrimidine-binding domain + Inosine triphosphate pyrophosphatase-like + SPRY domain + TauD/TfdA-like domain + Actin family + Endoribonuclease L-PSP/chorismate mutase-like + Cold-shock protein, DNA-binding + Peptidase C2, calpain family + Arf GTPase activating protein + Cobalamin (vitamin B12) biosynthesis CobW-like, C-terminal + Thiolase + Flavoprotein pyridine nucleotide cytochrome reductase + Hedgehog protein, Hint domain + Glycoside hydrolase family 3 C-terminal domain + Formin, FH2 domain + Tyrosine-protein kinase ephrin type A/B receptor-like + Phospholipase/carboxylesterase/thioesterase + Transmembrane protein TqsA-like + Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain + SLC26A/SulP transporter domain + 2Fe-2S ferredoxin, iron-sulphur binding site + Thioredoxin-like fold + C-type lectin-like + RNA polymerase sigma-70 region 2 + Choline transporter-like + Phosphoglycolate phosphatase, domain 2 + AsnC-type HTH domain + Aldehyde dehydrogenase, glutamic acid active site + ADP ribosyltransferase + TOPRIM domain + Peptidase M24 + Peptide methionine sulphoxide reductase MrsB + Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II + 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain + Beta-L-arabinofuranosidase, GH127 + Protein of unknown function DUF4326) + Neurotransmitter-gated ion-channel ligand-binding domain + Translation elongation factor EFTu-like, domain 2 + Enoyl-CoA hydratase/isomerase, conserved site + Isochorismatase-like + Exonuclease, phage-type/RecB, C-terminal + Peptidase S8, subtilisin, Ser-active site + Ubiquitin conserved site + PNPase/RNase PH domain + Aldo/keto reductase, conserved site + Sirtuin family + Phospholipid/glycerol acyltransferase + 50S ribosomal protein L30e-like + ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain + Integrase, catalytic domain + CbxX/CfqX + MCM domain + Amidase signature domain + OmpR/PhoB-type DNA-binding domain + Peptidase M16, C-terminal + Helicase/UvrB, N-terminal + Glycosyltransferase 34 + Glycine cleavage T-protein-like, N-terminal + Nucleotidyl transferase domain + Luciferase-like domain + 3-hydroxyacyl-CoA dehydrogenase, C-terminal + tRNA-dihydrouridine synthase, conserved site + Fibronectin type III + Nonaspanin (TM9SF) + RNA polymerase sigma-70 like domain + Chaperone DnaJ, C-terminal + FAD-binding, type 2, subdomain 1 + Haemolysin-type calcium-binding repeat + 6-phosphogluconate dehydrogenase, NADP-binding + ACT domain + Transcription factor CBF/NF-Y/archaeal histone domain + Polyketide synthase, ketoreductase domain + 4Fe-4S ferredoxin-type, iron-sulphur binding domain + FAD linked oxidase, N-terminal + Peptidase S1C + UBX domain + Glutaredoxin + Cyclin, N-terminal + Molybdopterin oxidoreductase + Integrase/recombinase, N-terminal + ENTH/VHS + Peptidase M14, carboxypeptidase A + Phosphoribosyltransferase domain + RecF/RecN/SMC, N-terminal + Bordetella uptake gene + GHMP kinase, C-terminal domain + Peptidase M3A/M3B catalytic domain + Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like + Peptidase M48 + Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding + Zinc/iron permease + PWWP domain + Peptidyl-prolyl cis-trans isomerase, PpiC-type + Helix-turn-helix, base-excision DNA repair, C-terminal + Alanine racemase/group IV decarboxylase, C-terminal + Transcription regulator AsnC/Lrp, ligand binding domain + Biotin carboxylase-like, N-terminal domain + Cation efflux protein + Tetracycline resistance protein TetA/multidrug resistance protein MdtG + D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain + PPM-type phosphatase, divalent cation binding + Histone-lysine N-methyltransferase DOT1 domain + Protein of unknown function UPF0301 + Elongation factor EFG, domain V-like + Cytochrome c oxidase-like, subunit I domain + Phosphatidylinositol 3-/4-kinase, catalytic domain + Oxidoreductase, N-terminal + Glutamine synthetase/guanido kinase, catalytic domain + Transcription regulator FadR/GntR, C-terminal + Pyrrolo-quinoline quinone repeat + FERM/acyl-CoA-binding protein, 3-helical bundle + Inositol monophosphatase-like + RING-type zinc-finger, LisH dimerisation motif + Patatin-like phospholipase domain + Amino acid/polyamine transporter I + GAF domain + Pentacotripeptide-repeat region of PRORP + DNA helicase Pif1-like + Aspartate/glutamate/uridylate kinase + Glycosyl transferase, family 25 + Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding + Saccharopine dehydrogenase, NADP binding domain + GroEL-like apical domain + Polyadenylate-binding protein/Hyperplastic disc protein + Mur ligase, central + PC-Esterase + Acetyl-CoA carboxylase + Pyridine nucleotide-disulphide oxidoreductase, class I, active site + Glycoside hydrolase family 47 + Homeobox, conserved site + IBR domain + Dehydrogenase, E1 component + Glycoside hydrolase family 31 + FYVE zinc finger + Dihydroxy-acid/6-phosphogluconate dehydratase + MarR-type HTH domain + UAA transporter + DNA methylase N-4/N-6 + LSM domain, eukaryotic/archaea-type + STAS domain + Band 7 domain + Glycine cleavage T-protein, C-terminal barrel domain + GDP-fucose protein O-fucosyltransferase + Cytidyltransferase-like domain + Mannose-6-phosphate receptor binding domain + Zinc finger, C2H2, APLF-like + Peptidase S24/S26A/S26B/S26C + Tubulin/FtsZ, 2-layer sandwich domain + Peptide chain release factor class I/class II + Protein of unknown function DUF3431 + Glutathione peroxidase + Antibiotic biosynthesis monooxygenase domain + Diacylglycerol acyltransferase + Sulfotransferase domain + Thiolase, conserved site + ClpA/B family + Voltage-gated potassium channel + Oxidoreductase, FAD-binding domain + Biotin carboxylase, C-terminal + TRAP transporter solute receptor DctP/TeaA + Anticodon-binding + Folate-biopterin transporter + ABC-transporter extension domain + DNA photolyase, N-terminal + Clp protease proteolytic subunit /Translocation-enhancing protein TepA + GntR, C-terminal + Aminotransferases, class-I, pyridoxal-phosphate-binding site + GYF-like domain + Heat shock protein 70kD, peptide-binding domain + Heat shock protein 70kD, C-terminal domain + NYN domain, limkain-b1-type + SecA DEAD-like, N-terminal + Cytochrome P450, conserved site + Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) + PUA domain + Gelsolin-like domain + Cytochrome b5, heme-binding site + Myb domain, plants + Proteasome component (PCI) domain + Sulfatase, conserved site + Beta-ketoacyl synthase, active site + tRNA (guanine-N-7) methyltransferase, Trmb type + Zinc finger, C3HC4 RING-type + Adenylate kinase, active site lid domain + Pseudouridine synthase, RluC/RluD, conserved site + D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site + Transcription regulator HTH, GntR + Clp ATPase, C-terminal + Coenzyme A transferase family I + 2-oxo acid dehydrogenase, lipoyl-binding site + Heavy metal-associated domain, HMA + Tetrapyrrole methylase, subdomain 1 + Peptidase family A1 domain + Peptidase S28 + Carbonic anhydrase + Enolase N-terminal domain-like + WGR domain + Exonuclease, RNase T/DNA polymerase III + Nitroreductase-like + Alcohol dehydrogenase, zinc-type, conserved site + Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant + Dpy-30 motif + Tail specific protease + Pectinacetylesterase/NOTUM + Aspartic peptidase A1 family + Fibronectin type III-like domain + Aromatic-ring-hydroxylating dioxygenase, alpha subunit + Tetratricopeptide repeat 1 + MerR-type HTH domain + Peptidyl-prolyl cis-trans isomerase, FKBP-type, N-terminal + NADH:flavin oxidoreductase/NADH oxidase, N-terminal + Transketolase, C-terminal domain + Ubiquitin-conjugating enzyme, active site + Phosphatidylinositol-4-phosphate 5-kinase, core + HhH-GPD domain + Glycoside hydrolase, family 27 + Restriction/modification DNA-methylase + OB-fold nucleic acid binding domain, AA-tRNA synthetase-type + Peptidase S8, subtilisin-related + GPS motif + Adenylate kinase subfamily + DNA methylase, C-5 cytosine-specific, active site + FAD-linked oxidoreductase-like + Cro/C1-type helix-turn-helix domain + Mitogen-activated protein (MAP) kinase, conserved site + YjgF/YER057c/UK114 family + HRDC domain + Glucose-methanol-choline oxidoreductase, C-terminal + ATP-dependent Clp protease proteolytic subunit + Sulfotransferase + MobA-like NTP transferase + Histone H2A/H2B/H3 + Annexin repeat + Pyruvate carboxyltransferase + Anaphase-promoting complex subunit 4, WD40 domain + Ulp1 protease family, C-terminal catalytic domain + Acyl-CoA-binding protein, ACBP + Haem oxygenase-like, multi-helical + Lon, substrate-binding domain + ParB/Sulfiredoxin + Glycolipid transfer protein domain + L,D-transpeptidase catalytic domain + FCP1 homology domain + Pseudouridine synthase I, TruA, C-terminal + Cysteine peptidase, histidine active site + Cysteine peptidase, asparagine active site + Hexapeptide transferase, conserved site + DNA helicase DnaB, N-terminal/DNA primase DnaG, C-terminal + Cys/Met metabolism, pyridoxal phosphate-dependent enzyme + SCP2 sterol-binding domain + C-5 cytosine methyltransferase + AIR synthase-related protein, C-terminal domain + Tubby, C-terminal + Nitronate monooxygenase + RNA polymerase sigma-70 + Orn/DAP/Arg decarboxylase 2, C-terminal + TRAP C4-dicarboxylate transport system permease DctM subunit + Protein of unknown function DUF3645 + Flavodoxin/nitric oxide synthase + Cysteine synthase/cystathionine beta-synthase, pyridoxal-phosphate attachment site + Peptidase S26A, signal peptidase I + Ribosomal RNA methyltransferase FtsJ domain + Cytochrome c oxidase subunit I + Vacuolar protein sorting-associated protein 13, N-terminal domain + Sugar/inositol transporter + Phosphatidylinositol-4-phosphate 5-kinase, C-terminal + Domain of unknown function DUF1605 + Thiolase, active site + Penicillin-binding protein, transpeptidase + Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains + Fumarate lyase, N-terminal + Trypanosoma cruzi ribosomal protein P2-like + Glycosyl transferase, family 20 + Membrane associated eicosanoid/glutathione metabolism-like domain + Resolvase, N-terminal catalytic domain + Regulator of K+ conductance, N-terminal + 5'-Nucleotidase, C-terminal + Transglutaminase-like + Fumarate lyase, conserved site + UbiA prenyltransferase family + Glycoside hydrolase family 2, catalytic domain + Sec63 domain + Non-haem dioxygenase N-terminal domain + Solute carrier family 13 + DNA ligase, ATP-dependent, central + UvrD-like DNA helicase, C-terminal + Aminoacyl-tRNA synthetase, class II (D/K/N) + Zinc finger, PARP-type + RNA binding activity-knot of a chromodomain + Glutamine synthetase, catalytic domain + ATPase, alpha/beta subunit, nucleotide-binding domain, active site + Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain + Synaptobrevin + Cytidine and deoxycytidylate deaminase domain + Carotenoid oxygenase + Glucose-6-phosphate dehydrogenase, C-terminal + Major intrinsic protein + Conserved hypothetical protein CHP02466 + Peptidoglycan binding-like + Polyprenyl synthetase + GIY-YIG nuclease superfamily + Tetrapyrrole methylase + Methyltransferase small domain + Serine carboxypeptidase, serine active site + Exoribonuclease, phosphorolytic domain 1 + Transposase IS3/IS911family + BSD domain + Clathrin/coatomer adaptor, adaptin-like, N-terminal + Protein of unknown function DUF3638 + Integral membrane protein TerC + Glucose-methanol-choline oxidoreductase, N-terminal + Dienelactone hydrolase + Carboxylesterase, type B + Phosphoglycerate mutase 1 + GHMP kinase N-terminal domain + Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain + 3-hydroxyisobutyrate dehydrogenase, NAD-binding domain + Aminotransferase class IV + (Uracil-5)-methyltransferase family + Orn/DAP/Arg decarboxylase 2, N-terminal + Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 + O-GlcNAc transferase, C-terminal + Fumarase/histidase, N-terminal + Macro domain + 3'5'-cyclic nucleotide phosphodiesterase + Alpha crystallin/Hsp20 domain + AhpD-like + DNA mismatch repair protein MutS, C-terminal + Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead + Glycosyltransferase subfamily 4-like, N-terminal domain + Threonyl/alanyl tRNA synthetase, SAD + Iron/zinc purple acid phosphatase-like C-terminal domain + Polyprenyl synthetase, conserved site + DSBA-like thioredoxin domain + Pyridine nucleotide-disulphide oxidoreductase, class-II + DENN domain + Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain + Flavin reductase like domain + Cupredoxin + Aromatic-ring-hydroxylating dioxygenase, alpha subunit, C-terminal domain + Succinyl-CoA synthetase-like + RND efflux pump, membrane fusion protein, barrel-sandwich domain + Vacuolar protein sorting-associated protein 13, second N-terminal domain + Creatinase/Aminopeptidase P/Spt16, N-terminal + DNA helicase, ATP-dependent, RecQ type + PAS fold + Cupin 2, conserved barrel + Glycosyl hydrolase family 30, TIM-barrel domain + Peptidase M23 + FAD-dependent oxidoreductase 2, FAD binding domain + Transcription regulator IclR, N-terminal + Fumarate lyase family + Tic22-like + Uracil-DNA glycosylase-like + Phosphatidic acid phosphatase type 2/haloperoxidase + Phosphoesterase + G-patch domain + CDP-alcohol phosphatidyltransferase + Sec1-like protein + RNA polymerase Rpb1, domain 1 + Serine hydrolase FSH + Acyltransferase ChoActase/COT/CPT + Ubiquitin system component Cue + Nitroreductase + Peptidase C2, calpain, large subunit, domain III + BolA protein + UmuC domain + Ribonucleotide reductase large subunit, C-terminal + MHCK/EF2 kinase + Probable zinc-binding domain + Kinesin light chain + Outer membrane protein/outer membrane enzyme PagP, beta-barrel + Tetrapyrrole methylase, subdomain 2 + Glycosyl transferase, family 14 + Epoxide hydrolase-like + Aminotransferase, class-II, pyridoxal-phosphate binding site + Glucosamine/galactosamine-6-phosphate isomerase + Cold-shock conserved site + Superoxide dismutase, copper/zinc binding domain + DJ-1/PfpI + Phosphatidylinositol-4-phosphate 5-kinase, N-terminal domain + Domain of unknown function DUF1995 + Zeta toxin domain + NUDIX hydrolase + Nucleoside phosphorylase domain + Chaperonin TCP-1, conserved site + Pseudouridine synthase, RsuA/RluB/E/F, conserved site + Alkaline phosphatase D-related + Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain + PQ-loop repeat + RlpA-like protein, double-psi beta-barrel domain + Methylthiotransferase, N-terminal + tRNA-binding domain + Polymerase, nucleotidyl transferase domain + UspA + TLDc domain + DNA binding HTH domain, AraC-type + Chaperone tailless complex polypeptide 1 (TCP-1) + Dihydroxy-acid/6-phosphogluconate dehydratase, conserved site + Cathepsin propeptide inhibitor domain (I29) + EH domain + FAD-linked oxidase, C-terminal + Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2 + Rad60/SUMO-like domain + 2-oxoacid dehydrogenase acyltransferase, catalytic domain + PurM-like, N-terminal domain + Amino acid ABC transporter, permease protein, 3-TM domain + Peptidase S49 + Guanylate-binding protein, N-terminal + Glutamine amidotransferase type 2 domain + DNA topoisomerase, type IA, central + Gamma-glutamyltranspeptidase + HAD-superfamily hydrolase, subfamily IIA + Transketolase, N-terminal + RelA/SpoT + Cryptochrome/DNA photolyase, FAD-binding domain + Radical SAM, alpha/beta horseshoe + Tubulin, conserved site + Phenylacetic acid degradation-related domain + Peptidase M41 + Peptidase M16, zinc-binding site + BEACH domain + Phospholipid methyltransferase + HD domain + MaoC-like domain + HAT, C-terminal dimerisation domain + Peptidase M1, alanyl aminopeptidase, C-terminal + Cation efflux protein, cytoplasmic domain + AP complex, mu/sigma subunit + DNA topoisomerase, type IIA + V-ATPase proteolipid subunit C-like domain + MoaB/Mog domain + Methylglyoxal synthase-like domain + RNA polymerase Rpb1, domain 5 + AdipoR/Haemolysin-III-related + Snf7 family + Solute-binding protein family 3/N-terminal domain of MltF + Importin-beta, N-terminal domain + Peptidase M17, leucyl aminopeptidase, C-terminal + Fe-S cluster assembly domain + R3H domain + NADH:ubiquinone oxidoreductase intermediate-associated protein 30 + Pyruvate kinase, barrel + Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein + Domain of unknown function DUF4339 + RAP domain + PIH1 domain + Proprotein convertase, P + Carbohydrate/puine kinase, PfkB, conserved site + tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG-related + Tripartite ATP-independent periplasmic transporter, DctQ component + Heat shock factor (HSF)-type, DNA-binding + Adaptor protein ClpS, core + RNA polymerase Rpb1, domain 3 + Serine carboxypeptidases, histidine active site + Transcription factor IIS, N-terminal + Branched-chain amino acid ATP-binding cassette transporter, C-terminal + tRNA-guanine(15) transglycosylase-like + Peptidase M17, leucine aminopeptidase/peptidase B + DHBP synthase RibB-like alpha/beta domain + Hemingway/KIAA1430 + DNA-binding recombinase domain + Transposase, Tn5-like, core + Domain of unknown function DUF218 + DNA polymerase, Y-family, little finger domain + Membrane transport protein + [2Fe-2S]-binding + Pirin, N-terminal domain + DNA binding HTH domain, Fis-type + Phospholipase D-like domain + Cation-transporting P-type ATPase, N-terminal + HNH endonuclease + Coenzyme Q-binding protein COQ10, START domain + Glutamine synthetase, glycine-rich site + Alanine racemase, N-terminal + Transcription regulator HTH, AsnC-type, conserved site + JAB1/MPN/MOV34 metalloenzyme domain + Adenosine/AMP deaminase domain + Oxidoreductase, molybdopterin-binding domain + Protein of unknown function DUF1295 + Pistil-specific extensin-like protein + Bacteriophage lambda, GpA + Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site + Vacuolar protein sorting-associated protein 13, C-terminal + Semialdehyde dehydrogenase, NAD-binding + DapA-like + DNA-directed DNA polymerase, family A, palm domain + Crp-type HTH domain + Carboxylesterase type B, active site + UvrD/AddA helicase, N-terminal + DNA topoisomerase, type IIA, subunit A/C-terminal + Nucleoside diphosphate kinase + DNA-directed DNA polymerase, family B, multifunctional domain + Redoxin + Sulfatase-modifying factor enzyme + RNA polymerase Rpb2, domain 2 + ADC synthase + Aldose 1-/Glucose-6-phosphate 1-epimerase + D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 + Putative 5-3 exonuclease + Peptidase S16, Lon proteolytic domain + Pyruvate kinase + Acetyl-CoA carboxylase, central domain + Maf-like protein + NADP transhydrogenase beta-like domain + Inorganic polyphosphate/ATP-NAD kinase, domain 1 + Inositol polyphosphate kinase + TSP type-3 repeat + Signal recognition particle, SRP54 subunit, GTPase domain + CAAX amino terminal protease + Formyl transferase, N-terminal + RNA polymerase, alpha subunit + Glycosyl transferase, family 51 + Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal + Glyceraldehyde/Erythrose phosphate dehydrogenase family + Domain of unknown function DUF21 + von Hippel-Lindau disease tumour suppressor, beta domain + Cytochrome b561, bacterial/Ni-hydrogenase + Transcriptional regulator MarR-type, conserved site + Acyl transferase + Phosphorylated CTD interacting factor 1, WW domain + Sigma-54 interaction domain, ATP-binding site 1 + Transposase DDE domain + E3-binding domain + Histidine triad (HIT) protein + Peptidase M16, middle/third domain + Sec7 domain + Peroxiredoxin-like FAM213/AAED1 + ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain + Biotin-binding site + Glycoside hydrolase, family 79 + Dbl homology (DH) domain + DNA topoisomerase, type IIA, central domain + DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta + Glutamyl/glutaminyl-tRNA synthetase + Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site + ClpA/B, conserved site 2 + SOUL haem-binding protein + Transcription regulator IclR, C-terminal + Ribonuclease H domain + GRIP domain + ATP-citrate lyase/succinyl-CoA ligase + APOBEC/CMP deaminase, zinc-binding + 6-phosphofructo-2-kinase + Doublecortin domain + Isopropylmalate dehydrogenase-like domain + Ornithine/DAP/Arg decarboxylase + Serine/threonine dehydratase, pyridoxal-phosphate-binding site + HEAT repeat + DNA topoisomerase, type IIA, subunit B, domain 2 + RND efflux pump, membrane fusion protein + Heavy-metal-associated, conserved site + Integration host factor (IHF)-like DNA-binding domain + Triosephosphate isomerase + Vesicle transport protein, Got1/SFT2-like + SLC41 divalent cation transporters, integral membrane domain + Peptide chain release factor + Ccc1 family + Outer membrane protein, bacterial + Glycosyl transferase, family 3 + Cytochrome P450, E-class, group I + RNA-dependent RNA polymerase, eukaryotic-type + Triosephosphate isomerase, active site + YqgF/RNase H-like domain + Mg2+ transporter protein, CorA-like/Zinc transport protein ZntB + Thiolase, acyl-enzyme intermediate active site + Sec7 domain, alpha orthogonal bundle + Hedgehog signalling/DD-peptidase zinc-binding domain + Lupus La protein + Polyketide synthase, dehydratase domain + Proton-dependent oligopeptide transporter family + Arginine repressor C-terminal-like domain + Complex 1 LYR protein + NADH:cytochrome b5 reductase (CBR) + HD/PDEase domain + Peptidase S33 + Eukaryotic molybdopterin oxidoreductase + CHAT domain + GGDEF domain + Homoserine dehydrogenase, catalytic + Regulator of K+ conductance, C-terminal + Transcription regulator LuxR, C-terminal + Activator of Hsp90 ATPase, N-terminal + Clp, N-terminal + Bax inhibitor 1-related + ClpA/B, conserved site 1 + Flavodoxin-like + Glutamyl/glutaminyl-tRNA synthetase, class Ib, alpha-bundle domain + Chloride channel, core + Alpha-D-phosphohexomutase, conserved site + UDPGP family + Glycerophosphodiester phosphodiesterase domain + Zinc finger, GRF-type + Phosphoglycerate kinase + Peptidase M8, leishmanolysin + Protein of unknown function DUF2924 + Arc-type ribbon-helix-helix + Aspartyl/Asparaginyl-tRNA synthetase, class IIb + Alpha-D-phosphohexomutase, alpha/beta/alpha domain I + Ppx/GppA phosphatase + Peptidase S9A, prolyl oligopeptidase + TerB-like + DNA-directed RNA polymerase, subunit 2, domain 6 + Endoplasmic reticulum vesicle transporter, C-terminal + Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35 + Enoyl-CoA hydratase/isomerase, HIBYL-CoA-H type + Citrate transporter-like domain + La-type HTH domain + MIT + Peptidase M1, membrane alanine aminopeptidase, N-terminal + Histone-like DNA-binding protein + ATP synthase subunit alpha-like domain + ArgE/DapE/ACY1/CPG2/YscS, conserved site + Methionyl/Leucyl tRNA synthetase + HTH ArsR-type DNA-binding domain + Fringe-like + Vacuolar protein sorting-associated protein 13, SHR-binding domain + Glyceraldehyde-3-phosphate dehydrogenase, type I + Phage portal protein, lambda family + Glyceraldehyde 3-phosphate dehydrogenase, active site + WD40-like Beta Propeller + EAL domain + Exoribonuclease, phosphorolytic domain 2 + SWEET sugar transporter + Uncharacterised protein family UPF0061 + HpcH/HpaI aldolase/citrate lyase domain + Putative RNA methylase domain + Cytochrome c oxidase-like subunit III + Formate/nitrite transporter + RNA polymerase sigma factor 54 interaction domain + YbaK/aminoacyl-tRNA synthetase-associated domain + GTP cyclohydrolase II + Pseudouridine synthase I, TruA, alpha/beta domain + Capsular polysaccharide synthesis + Phosphoglycerate kinase, N-terminal + DNA ligase, ATP-dependent, C-terminal + DNA ligase, ATP-dependent, N-terminal + RGS domain + Magnesium-dependent phosphatase-1, eukaryotic/archaeal-type + Aminoacyl-tRNA synthetase, class Ic + C-type lectin, conserved site + XPG-I domain + XPG/Rad2 endonuclease + ADP-ribosylation/Crystallin J1 + Mur ligase, C-terminal + Tubulin + Type IIA DNA topoisomerase subunit A, alpha-helical domain + Ribosomal protein L4 domain + Methylthiotransferase + DNA glycosylase/AP lyase, H2TH DNA-binding + Glycoside hydrolase family 20, catalytic domain + Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain + COMM domain + Membrane insertase OXA1/ALB3/YidC + Ribonuclease T2-like + Peptidase C65, otubain + Aconitase/3-isopropylmalate dehydratase, swivel + Chloride channel, voltage gated + FATC domain + Bacterial surface antigen (D15) + Peptidase C69, dipeptidase A + Domain of unknown function DUF2431 + Electron transfer flavoprotein, alpha/beta-subunit, N-terminal + Glutaredoxin active site + S-adenosylmethionine-dependent methyltransferase + Peptidase S9A, N-terminal domain + Zinc finger, ZZ-type + Zinc finger, A20-type + Valine-tRNA ligase + Outer membrane protein beta-barrel + Ribosomal protein L5 domain + Glutaredoxin subgroup + Glucose-6-phosphate dehydrogenase, active site + Peptidase A8, signal peptidase II + Methylthiotransferase, conserved site + JmjN domain + Bacteriophage phiJL001, Gp84, N-terminal + Ribosomal protein L7Ae/L30e/S12e/Gadd45 + Oligopeptide/dipeptide ABC transporter, C-terminal + Ribosomal protein L3 + Malate synthase + WHEP-TRS domain + Paired amphipathic helix + MCM OB domain + NodB homology domain + Mur ligase, N-terminal catalytic domain + PIN domain + Protein ENHANCED DISEASE RESISTANCE 2, C-terminal + Protein of unknown function DUF393 + D-galactarate/Altronate dehydratase, C-terminal + SsuA/THI5-like + Cytochrome b561/ferric reductase transmembrane + Cytochrome c assembly protein + Ammonium transporter, conserved site + Pirin, C-terminal domain + Methylthioribose-1-phosphate isomerase-like, N-terminal domain + Protein of unknown function DUF4336 + Glutamate synthase domain + Squalene/phytoene synthase + Carbamoyl-phosphate synthase large subunit, CPSase domain + Strawberry notch, helicase C domain + Sugar isomerase (SIS) + RWD domain + Ergosterol biosynthesis ERG4/ERG24 + Ribosomal protein L1/ribosomal biogenesis protein + Peptidase S26A, signal peptidase I, lysine active site + Tip attachment protein J + Ubiquitin interacting motif + RNA polymerase sigma-70 region 3 + Glutathione peroxidase conserved site + TatD family + Ribosomal protein L10P + Ribulose-phosphate 3-epimerase-like + Zinc finger, Sec23/Sec24-type + Sec23/Sec24, trunk domain + Domain of unknown function DUF4116 + GTA TIM-barrel-like domain + Aspartate/ornithine carbamoyltransferase + TGS + Aconitase family, 4Fe-4S cluster binding site + Glucose-6-phosphate dehydrogenase + Inorganic pyrophosphatase + Adrenodoxin + Glutamate/acetylglutamate kinase + RNA polymerase Rpb2, domain 3 + ClpP, histidine active site + Chorismate-utilising enzyme, C-terminal + Sodium/solute symporter + UDP-glucose/GDP-mannose dehydrogenase, N-terminal + Ferrochelatase + Glucose-6-phosphate dehydrogenase, NAD-binding + Purple acid phosphatase, N-terminal + FeS cluster biogenesis + Cobalamin (vitamin B12)-binding domain + Ubiquitin fusion degradation protein Ufd1-like + Translation elongation factor, KOW-like + tRNA methyltransferase TRMD/TRM10-type domain + Alpha-D-phosphohexomutase, alpha/beta/alpha domain III + Alpha-D-phosphohexomutase, C-terminal + DNA topoisomerase, type IIA, conserved site + CLASP N-terminal domain + Transcription termination factor, mitochondrial/chloroplastic + Amidohydrolase + Signal transduction histidine kinase, phosphotransfer (Hpt) domain + E2F/DP family, winged-helix DNA-binding domain + Glucose/Sorbosone dehydrogenase + UDP-glucose 4-epimerase + Lactate/malate dehydrogenase, C-terminal + Pseudouridine synthase, TruD + Thiamine phosphate synthase/TenI + Helix-hairpin-helix motif + Potassium channel tetramerisation-type BTB domain + DNA methylase, adenine-specific + Pyrroline-5-carboxylate reductase, catalytic, N-terminal + Target SNARE coiled-coil homology domain + Alpha-mannosyltransferase + Carbohydrate kinase, FGGY, N-terminal + Carbohydrate kinase, FGGY, C-terminal + Chaperonin Cpn60 + ATP synthase, F1 complex, gamma subunit + Amidohydrolase 3 + Ribosomal protein L11, C-terminal + Phosphatidylinositol 3/4-kinase, conserved site + Na+/H+ exchanger + Methylenetetrahydrofolate reductase + Protein of unknown function DUF1538 + Peptidase C19, ubiquitin-specific peptidase, DUSP domain + Tex-like domain + K Homology domain, type 2 + Protein of unknown function DUF1499 + Protein of unknown function DUF1501 + Glutathione-dependent formaldehyde-activating enzyme/centromere protein V + DNA mismatch repair protein MutS, N-terminal + Cullin, N-terminal + Pseudouridine synthase, RsuA/RluB/E/F + ELO family + SHOCT domain + Vanillyl-alcohol oxidase, C-terminal subdomain 2 + Outer membrane efflux protein + Protein of unknown function DUF1275 + DNA recombination and repair protein Rad51-like, C-terminal + Glycosyl transferase, family 48 + Domain of unknown function DUF305 + Vps16, C-terminal + SWAP/Surp + RNA polymerase sigma-70 region 4 + AAA domain + Amino acid exporter protein, LeuE-type + Zinc finger, LIM-type + Uroporphyrinogen decarboxylase (URO-D) + Phospholipase B-like + Copper chaperone SCO1/SenC + Xylanase inhibitor, N-terminal + Translation elongation factor EFTu/EF1A, C-terminal + Adenosylhomocysteinase-like + 3-oxoacid CoA-transferase, subunit A + Isoleucine-tRNA ligase + Glycosyl transferase family 10 + SMCs flexible hinge + Variant SH3 domain + Inositol monophosphatase, metal-binding site + XPG N-terminal + Ribosomal protein L14P + Beta-hexosaminidase + ThiamineS/Molybdopterin converting factor subunit 1 + Sporulation-related domain + TonB-dependent receptor, conserved site + ATP-dependent DNA helicase RecQ, zinc-binding domain + EEIG1/EHBP1 N-terminal domain + Signal recognition particle, SRP54 subunit, M-domain + Integrase, DNA-binding domain + Metalloenzyme + Bacterial DNA polymerase III, alpha subunit + AP endonuclease 1 + Porphobilinogen deaminase, N-terminal + Proteasome beta-type subunit, conserved site + DNA ligase, ATP-dependent, conserved site + Gdt1 family + MotA/TolQ/ExbB proton channel + Enolase + NRAMP family + NAD/GMP synthase + SUI1 domain + Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal + Hemimethylated DNA-binding domain + Membrane transport protein MMPL domain + Ribosomal Proteins L2, RNA binding domain + Ribosomal protein L2, C-terminal + Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain + DNA mismatch repair protein MutS-like, N-terminal + DNA mismatch repair protein MutS, core + Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal + Nucleosome assembly protein (NAP) + Protein of unknown function DUF2460 + GTP1/OBG domain + Histone H2A + Transglycosylase SLT domain 1 + Transaldolase/Fructose-6-phosphate aldolase + PKD/REJ-like domain + Ribosomal protein S8 + RmlD-like substrate binding domain + CobQ/CobB/MinD/ParA nucleotide binding domain + Peptidase A22B, signal peptide peptidase + Inosine/uridine-preferring nucleoside hydrolase domain + Zn-dependent metallo-hydrolase, RNA specificity domain + Nitrite/Sulfite reductase ferredoxin-like domain + uDENN domain + 4'-phosphopantetheinyl transferase superfamily + PEP-utilising enzyme, mobile domain + Proline dehydrogenase domain + DegT/DnrJ/EryC1/StrS aminotransferase + Acyltransferase 3 + Cytochrome b/b6-like domain + Molybdenum cofactor sulfurase, C-terminal + Calcineurin-like phosphoesterase domain, lpxH type + Thymidylate synthase/dCMP hydroxymethylase domain + Polyketide cyclase/dehydrase + NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain + Peroxidase, active site + Heat shock protein Hsp90 family + Cytochrome P450, E-class, group IV + ClpP, Ser active site + Ribosomal protein S10 domain + LETM1-like + Signal recognition particle, SRP54 subunit, helical bundle + DNA topoisomerase, type IA, central region, subdomain 2 + Translation Initiation factor eIF- 4e-like + RNA polymerase sigma-70 region 1.2 + Na-Ca exchanger/integrin-beta4 + Surfeit locus 4 + HAMP domain + Cell division protein FtsZ, conserved site + Transporter-associated domain + Protein of unknown function DUF3110 + GrpE nucleotide exchange factor, coiled-coil + ENTH domain + Phosphoadenosine phosphosulphate reductase + DTW + Translation initiation factor IF- 2, domain 3 + Tyrosine/serine-protein phosphatase IphP-type + SRCR domain + Flagellar basal body rod protein, N-terminal + Decaprenyl diphosphate synthase-like + SUF system FeS cluster assembly, SufBD + UDP-glucose/GDP-mannose dehydrogenase, dimerisation + PEP-utilising enzyme, C-terminal + TRAF-like + ATPase, AFG1-like + Putative esterase + Notch domain + Ricin B, lectin domain + GATS-like ACT domain + Saccharopine dehydrogenase, C-terminal + Glycoside hydrolase family 1 + Ham1-like protein + Aconitase A/isopropylmalate dehydratase small subunit, swivel domain + Ribosomal protein S9 + Glycoside hydrolase family 16 + Aminoacyl-tRNA synthetase, class I, anticodon-binding domain, subdomain 2 + Syntaxin/epimorphin, conserved site + Protein of unknown function DUF2793 + Histone H3/CENP-A + Replication factor-A protein 1, N-terminal + FAD dependent oxidoreductase, central domain + Inositol monophosphatase, conserved site + Peptidase C78, ubiquitin fold modifier-specific peptidase 1/ 2 + Zinc finger, NHR/GATA-type + BRO1 domain + Peptidase S26A, signal peptidase I, conserved site + Zinc finger, CHC2-type + Glutathione synthase + Oligopeptide transport permease C-like, N-terminal domain + Thiosulphate sulfurtransferase, conserved site + Mu homology domain + Thiaminase-2/PQQC + Ribosomal protein L6, alpha-beta domain + Threonine synthase, N-terminal + PBP domain + DNA-directed RNA polymerase, RpoA/D/Rpb3-type + NADH:ubiquinone oxidoreductase + Methylmalonyl-CoA mutase, alpha/beta chain, catalytic + Translation elongation factor EFG/EF2, domain IV + Glutamine synthetase, beta-Grasp domain + Sec23/Sec24 beta-sandwich + Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding + Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain + Histidine phosphatase superfamily, clade-2 + Sodium/calcium exchanger protein + Pyridoxamine kinase/Phosphomethylpyrimidine kinase + Pterin-binding domain + Herpesvirus/Caudovirus protease domain + AIG1-type guanine nucleotide-binding (G) domain + Cryptochrome/DNA photolyase class 1 + Ribosomal protein L13 + GTP-binding protein, ribosome biogenesis, YsxC + NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site + Mib-herc2 + RNA polymerase, beta subunit, protrusion + RNA polymerase Rpb2, domain 7 + ATP synthase, F0 complex, subunit b/b', bacterial/chloroplast + Carboxymuconolactone decarboxylase-like + Selenoprotein Sep15/SelM + Protein of unknown function DUF1800 + Pyridoxal phosphate-dependent decarboxylase + Domain of unknown function DUF814 + Peptidase M24, methionine aminopeptidase + CarD-like/TRCF domain + Ribosomal protein L18e/L15P + CDC48 domain 2-like + Ribonuclease III domain + Tyrosyl-DNA phosphodiesterase I + Axonemal dynein light chain + HAD-superfamily hydrolase, subfamily IIB + Ribosomal protein L2, domain 3 + Aspartate/homoserine dehydrogenase, NAD-binding + Development/cell death domain + Coagulation factor 5/8 C-terminal domain + Proteasome alpha-subunit, N-terminal domain + Initiation factor 2B-related + Phenylalanyl-tRNA synthetase + Alpha-D-phosphohexomutase, alpha/beta/alpha domain II + Alpha-D-phosphohexomutase superfamily + Mini-chromosome maintenance, conserved site + ADP/ATP carrier protein + Leucine rich repeat 4 + Diacylglycerol kinase, catalytic domain + Nucleoside phosphatase GDA1/CD39 + Villin/Gelsolin + RNA polymerase, beta subunit, conserved site + Peptide deformylase + Glycosyl hydrolase family 92 + CRIB domain + Transaldolase, active site + Ubiquitin-activating enzyme, catalytic cysteine domain + Homocysteine-binding domain + Hydantoinase/oxoprolinase + Brix domain + Trehalose-phosphatase + Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, C-terminal + Glycosyl transferase, family 15 + SEC-C motif + Soluble ligand binding domain + Ribosomal protein S2 + Ribonuclease HII/HIII domain + Glycoside hydrolase family 27/36, conserved site + Mandelate racemase/muconate lactonizing enzyme, N-terminal domain + Cytochrome c oxidase, subunit III, 4-helical bundle + Nucleoporin FG repeat + Enolpyruvate transferase domain + Ribosomal protein S15 + Creatinase, N-terminal + DNA mismatch repair protein MutS, connector domain + Enolase, C-terminal TIM barrel domain + Enolase, N-terminal + Histone-like DNA-binding protein, conserved site + Sigma-54 interaction domain, conserved site + Ribosomal protein S10 + Chromate transporter + GrpE nucleotide exchange factor, head + Transcription elongation factor S-II, central domain + Succinate dehydrogenase/fumarate reductase type B, transmembrane subunit + ATPase, F1/V1 complex, beta/alpha subunit, C-terminal + Cleft lip and palate transmembrane 1 + PAS fold-3 + SMP-30/Gluconolactonase/LRE-like region + Gamma-tubulin complex component protein + Mce/MlaD + Bacteriophage phiJL001, Gp84 + NADPH-dependent FMN reductase-like + Impact, N-terminal + IMP dehydrogenase/GMP reductase + Tyrosyl-DNA phosphodiesterase C-terminal domain + Histone H1-like nucleoprotein HC2 + MT-A70-like + Transmembrane Fragile-X-F-associated protein + Glycosyl transferase, family 28, C-terminal + Biopolymer transport protein ExbD/TolR + GrpE nucleotide exchange factor + Pyridoxamine 5'-phosphate oxidase, putative + LysM domain + Dihydrofolate reductase-like domain + Cobalamin (vitamin B12)-dependent enzyme, catalytic + Methyltransferase Ppm1/Ppm2/Tcmp + CCB3/YggT + Platelet-activating factor acetylhydrolase-like + Ribosomal RNA small subunit methyltransferase H + DNA-directed RNA polymerase, insert domain + Haem peroxidase, plant/fungal/bacterial + SbmA/BacA-like + Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL), catalytic domain + Arginyl-tRNA synthetase, catalytic core domain + Endopeptidase, NLPC/P60 domain + Ribosomal protein L5, C-terminal + Pyruvate kinase, C-terminal + Alanyl-tRNA synthetase, class IIc, N-terminal + Cell division protein FtsZ, C-terminal + NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain + Xylanase inhibitor, C-terminal + Histidine biosynthesis + Citrate synthase active site + Gcp-like domain + Ribosomal protein L25/Gln-tRNA synthetase, beta-barrel domain + Sialidases + Chaperonin Cpn60, conserved site + Phosphoribulokinase/uridine kinase + Poly(ADP-ribose) polymerase, regulatory domain + Protein of unknown function DUF1415 + IMP-specific 5-nucleotidase + DNA polymerase, palm domain + Glycoside hydrolase, family 76 + Basic-leucine zipper domain + Manganese/iron superoxide dismutase, C-terminal + Manganese/iron superoxide dismutase, binding site + Manganese/iron superoxide dismutase, N-terminal + Orotidine 5'-phosphate decarboxylase domain + Ribosomal protein L9, N-terminal + tRNA(Ile)-lysidine/2-thiocytidine synthase, N-terminal + Ribosomal protein S19, superfamily + Thioredoxin + Glycoside hydrolase family 38, central domain + Ribosomal protein S15, bacterial-type + Putative transposase IS4/IS5 family + Ribosomal protein L22/L17 + Ribosomal protein L31 + Guanylate kinase/L-type calcium channel beta subunit + Multicopper oxidase, type 2 + Multicopper oxidase, type 3 + MIF4G-like, type 3 + Aromatic-ring-hydroxylating dioxygenase, 2Fe-2S-binding site + Elongation factor P, C-terminal + Ribosomal protein L20 + Phage capsid + Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich + Ribosomal protein L4/L1e + Glycosyl hydrolases family 2, sugar binding domain + Ribokinase/fructokinase + Protein-tyrosine phosphatase, SIW14-like + Ubiquitin-activating enzyme E1, Cys active site + Molybdate-anion transporter + Golgi apparatus membrane protein TVP15 + AP endonuclease 1, binding site + Flagellar calcium-binding protein calflagin + Zinc finger, DksA/TraR C4-type + Staphylococcal nuclease (SNase-like), OB-fold/extended TUDOR domain + PITH domain + Ribosomal protein S2, bacteria/mitochondria/plastid + Homogentisate 1,2-dioxygenase + Lactonase, 7-bladed beta propeller + Clathrin adaptor, mu subunit + Dynamin central domain + Ribosomal protein S11 + Dephospho-CoA kinase + Peptidogalycan biosysnthesis/recognition + Sporulation stage V, protein S + Translation elongation factor EF1B/ribosomal protein S6 + Amino acid permease/ SLC12A domain + DHHA1 domain + NiFe hydrogenase-like + Neurolysin/Thimet oligopeptidase, N-terminal + ATP-dependent (S)-NAD(P)H-hydrate dehydratase + Myc-type, basic helix-loop-helix (bHLH) domain + Ribosomal protein S20 + Threonine synthase-like + Ribosomal protein S5, C-terminal + GRAM domain + Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B + N2227-like + Aminotransferase class-V, pyridoxal-phosphate binding site + DNA mismatch repair protein, C-terminal + Ribonucleotide reductase large subunit, N-terminal + Ribosomal protein S4/S9, N-terminal + Domain of unknown function DUF971 + W2 domain + Fido domain + Capsule polysaccharide biosynthesis + Ribonuclease T2, His active site 1 + Kringle + ABC-2 transporter + Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain + Batten's disease protein Cln3 + Acylneuraminate cytidylyltransferase + Cytochrome c, class IA/ IB + ApaG domain + Tubulin binding cofactor C-like domain + PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase + Porphobilinogen deaminase + 3-hydroxyacyl-CoA dehydrogenase, conserved site + Mitochondrial 18kDa protein + PPPDE putative peptidase domain + Zinc finger, UBR-type + WH2 domain + Ribosomal protein L7/L12, C-terminal + ATP phosphoribosyltransferase, catalytic domain + GTP-binding protein, orthogonal bundle domain + Ribosomal protein L7/L12, oligomerisation + Molybdopterin dehydrogenase, FAD-binding + Protein of unknown function DUF2358 + WHIM2 domain + ATP-dependent RNA helicase Ski2, C-terminal + Endonuclease III-like, conserved site-2 + KOW + Enolase, conserved site + Ribosome recycling factor domain + Phosphoenolpyruvate carboxykinase, ATP-utilising + Ribosomal protein L1, 3-layer alpha/beta-sandwich + FeS cluster insertion protein + TsaA-like domain + Phosphate acetyl/butaryl transferase + Sodium:dicarboxylate symporter + Phenylalanyl-tRNA synthetase, B3/B4 + Chorismate mutase, type II + N6 adenine-specific DNA methyltransferase, N-terminal domain + Endoplasmic reticulum oxidoreductin 1 + GYF domain + Ribosomal protein L21-like + YqaJ viral recombinase + Methioninyl-tRNA synthetase core domain + Mrp, conserved site + Prohead protease + Phospholipase D, N-terminal + TspO/MBR-related protein + GTP-binding protein LepA, C-terminal + Type II secretion system protein E + Histone deacetylase + Heat shock protein Hsp90, N-terminal + DNA gyrase B subunit, C-terminal + Carbamoyl-phosphate synthetase, large subunit oligomerisation domain + MCP methyltransferase, CheR-type, SAM-binding domain, C-terminal + Aspartate kinase domain + Villin headpiece + S-adenosyl-L-homocysteine hydrolase, NAD binding domain + START domain + Ribosomal protein S12/S23 + Ureohydrolase + Pheophorbide a oxygenase + Peptidyl-tRNA hydrolase + Ribosomal protein L5, N-terminal + Peptidase S26A, signal peptidase I, serine active site + Adenylosuccinate synthetase + AICARFT/IMPCHase bienzyme + Aspartate/other aminotransferase + Uroporphiryn-III C-methyltransferase, conserved site + tRNA methyltransferase, Trm1 + Citrate synthase + Putative pre-16S rRNA nuclease + Class II aldolase/adducin N-terminal + Mechanosensitive ion channel MscS + Histidine triad, conserved site + FMN-dependent dehydrogenase + Ribosomal protein S17/S11 + FAD-dependent glycerol-3-phosphate dehydrogenase + 3-beta hydroxysteroid dehydrogenase/isomerase + GTP1/OBG, conserved site + Protein of unknown function DUF952 + Ribosomal protein S13 + Formamidopyrimidine-DNA glycosylase, catalytic domain + Exportin-1/Importin-beta-like + Protein of unknown function DUF3489 + Protein of unknown function DUF839 + UbiA prenyltransferase conserved site + 3-hydroxyisobutyrate dehydrogenase-related, conserved site + SecY/SEC61-alpha family + Polycystic kidney disease type 2 protein + Transcription regulator MerR, DNA binding + Fe-S hydro-lyase, tartrate dehydratase alpha-type, catalytic domain + NIF system FeS cluster assembly, NifU, C-terminal + Ribosomal protein L25/L23 + Domain of unknown function DUF933 + Domain of unknown function DUF1214 + MCM N-terminal domain + EXS, C-terminal + Alpha-N-methyltransferase NTM1 + Squalene/phytoene synthase, conserved site + Cyclin PHO80-like + Protein of unknown function DUF900, hydrolase-like + Ribosomal RNA small subunit methyltransferase E + Smr domain + Ribosomal protein L13, bacterial-type + Glycosyltransferase family 92 + Translation elongation factor P/YeiP, central + Ribosomal protein L10e/L16 + DNA primase, catalytic core, N-terminal + DNA mismatch repair, conserved site + Ribonuclease T2, His active site 2 + Carbonic anhydrase, prokaryotic-like, conserved site + SH3 domain + ROK family + Thioesterase + RNA methyltransferase TrmA, active site + RNA methyltransferase TrmA, conserved site + Restriction endonuclease, type I, HsdR, N-terminal + GxGYxYP putative glycoside hydrolase, C-terminal + Ribosomal protein S7 domain + Parallel beta-helix repeat-2 + FIST domain, N-terminal + Peptidase C12, ubiquitin carboxyl-terminal hydrolase + Rho GTPase-activating protein domain + Histone H2A conserved site + Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase + Ribosomal protein L2, conserved site + Double-stranded RNA-binding domain + Actin-depolymerising factor homology domain + CO dehydrogenase flavoprotein, C-terminal + MacB-like periplasmic core domain + Tyrosine-protein kinase, active site + SOS response associated peptidase (SRAP) + Aromatic amino acid beta-eliminating lyase/threonine aldolase + 3,4-dihydroxy-2-butanone 4-phosphate synthase, RibB + Alanine-tRNA ligase, class IIc + Cytochrome c oxidase, subunit I, copper-binding site + Hydantoinase B/oxoprolinase + Domain of unknown function DUF2470 + Acetyl-CoA dehydrogenase-like C-terminal domain + L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase + Phosphate transporter + Ribosomal protein S14 + Syntaxin 6, N-terminal + Indoleamine 2,3-dioxygenase + Haem-binding uptake, Tiki superfamily, ChaN + Alpha-isopropylmalate/homocitrate synthase, conserved site + Deoxyribonuclease, TatD-related, conserved site + Hydantoinaseoxoprolinase, N-terminal + Poly(ADP-ribose) glycohydrolase + NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding + B3/B4 tRNA-binding domain + Beta-Casp domain + Phenol hydroxylase reductase + Kae1/TsaD family + Ribosomal protein S30Ae/sigma 54 modulation protein + Multicopper oxidase, copper-binding site + Disulphide bond formation protein DsbB-like domain + Ribosomal protein L2, bacterial/organellar-type + Alternative oxidase + PsbP family + DALR anticodon binding + CinA, C-terminal + UDP-glucose/GDP-mannose dehydrogenase + Copper type II, ascorbate-dependent monooxygenase-like, C-terminal + ABC transporter permease protein domain + Cytochrome C biogenesis protein, transmembrane domain + MIP18 family-like + Guanylate kinase + Metalloprotease TldD/PmbA + Manganese/iron superoxide dismutase + CTP synthase, N-terminal + NB-ARC + GTP-binding protein Obg/CgtA + Galactokinase galactose-binding domain + Peptidase S26 + Zinc finger, double-stranded RNA binding + Carbohydrate kinase, FGGY, conserved site + Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal + HTH-like domain + Coproporphyrinogen III oxidase, aerobic + NADH:ubiquinone oxidoreductase, 30kDa subunit + XK-related protein + Vps4 oligomerisation, C-terminal + Sulphur transport domain + Ribosomal protein S5, N-terminal + Acetyl-coenzyme A synthetase, N-terminal domain + APC10/DOC domain + Ribosomal protein S19/S15 + Cytochrome P450, B-class + Flavin amine oxidase + RNA polymerase Rpb1, domain 4 + Ribosomal protein L11, N-terminal + Chorismate mutase + PAS fold-4 + Mitochondrial inner membrane translocase subunit Tim17/Tim22/Tim23/peroxisomal protein PMP24 + NlpC/P60 family, putative phage cell wall peptidase + Transposase, IS4-like + FAD-binding, type 1 + Glycosyltransferase family 28, N-terminal domain + AICAR transformylase domain + Dynein light chain, type 1/2 + PIK-related kinase, FAT + Domain of unknown function DUF1601 + Thiamine pyrophosphate enzyme, C-terminal TPP-binding + Type II secretion system F domain + Nitrogen regulatory protein PII/ATP phosphoribosyltransferase, C-terminal + Serine-tRNA synthetase, type1, N-terminal + ATP synthase, F0 complex, subunit A + Fructose-bisphosphate aldolase, class-I + DNA polymerase A + NnrU domain + NusB/RsmB/TIM44 + Phosphoribosylglycinamide synthetase, C-domain + Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain + Transport-associated OB, type 2 + Domain of unknown function DUF1736 + ABC-type glycine betaine transport system, substrate-binding domain + Helitron helicase-like domain + tRNA synthetases class I, catalytic domain + DNA photolyase class 2, conserved site + YVTN beta-propeller repeat + DAHP synthetase, class II + SPX domain + Peptidase, FtsH + DNA methylase, N-4 cytosine-specific, conserved site + Domain of unknown function DUF1330 + Xanthine/uracil/vitamin C permease + Chalcone/stilbene synthase, C-terminal + Meckelin + ArgJ-like domain + Paraquat-inducible protein A + DNA methylase, C-5 cytosine-specific, conserved site + Signal transduction histidine kinase, subgroup 2, dimerisation and phosphoacceptor domain + Kelch repeat type 2 + TPMT family + Oxidoreductase, C-terminal + Glycoside hydrolase family 31, N-terminal domain + Magnesium chelatase ChlI domain + Ribosomal protein S6 + Indole-3-glycerol phosphate synthase + CoA-binding + COX15/CtaA family + Protein arginine methyltransferase NDUFAF7 + P-type ATPase, subfamily IB + Bicarbonate transporter, C-terminal + GHMP kinase, ATP-binding, conserved site + Bromodomain, conserved site + Cation-transporting P-type ATPase, C-terminal + Malic enzyme, N-terminal domain + Malic enzyme, NAD-binding + Methyltransferase type 12 + DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat + HAD-superfamily phosphatase, subfamily IIIC + Translation initiation factor 3, C-terminal + Isocitrate/isopropylmalate dehydrogenase, conserved site + Flagellar basal-body/hook protein, C-terminal domain + NADH dehydrogenase ubiquinone Fe-S protein 4, mitochondrial + Membrane insertase YidC/Oxa1, C-terminal + Major intrinsic protein, conserved site + RNA-polymerase II-associated protein 3-like, C-terminal domain + G8 domain + Translation elongation factor EFTs/EF1B + Non-canonical purine NTP phosphatase/PRRC1 + Glutamate-ammonia ligase adenylyltransferase, repeated domain + 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III + Staphylococcal nuclease (SNase-like), OB-fold + MgtC/SapB/SrpB/YhiD family + Zinc finger, TRAF-type + UDP-glucose:Glycoprotein Glucosyltransferase + Hydroxyacylglutathione hydrolase, C-terminal domain + Ribosomal protein L15, bacterial-type + Ribosomal protein L14P, bacterial-type + ATP synthase, F1 complex, alpha subunit + Phosphoenolpyruvate carboxykinase, C-terminal + RNA-binding protein AU-1/Ribonuclease E/G + DEAD2 + Methionyl-tRNA synthetase + Periplasmic solute binding protein, ZnuA-like + Folylpolyglutamate synthetase, conserved site + Ribosomal S11, conserved site + Semialdehyde dehydrogenase, dimerisation domain + ATP:guanido phosphotransferase, catalytic domain + Porphobilinogen deaminase, C-terminal + Ribosome-binding factor A + Haem oxygenase-like + ERV/ALR sulfhydryl oxidase domain + ACT-like domain + Malate/L-lactate dehydrogenase-like + dUTPase-like + Domain of unknown function DUF892 + Transcription regulator Rrf2-type + Dihydroorotate dehydrogenase domain + DNA-directed RNA polymerase, beta subunit, external 1 domain + XPC-binding domain + Xylose isomerase-like, TIM barrel domain + Protein-export membrane protein SecD/SecF, bacterial + Protein of unknown function DUF4231 + Heat shock protein Hsp33 + Histone H4 + CSN8/PSMD8/EIF3K + Digestive organ expansion factor, predicted + Vps72/YL1, C-terminal + Mitochondrial fission protein ELM1-like + Adrenodoxin, iron-sulphur binding site + Thiamine pyrophosphate enzyme, central domain + Ribosomal protein L33 + Protein O-mannosyl-transferase, C-terminal four TM domain + Ribosomal protein S3, bacterial + Ribosomal protein L1, bacterial-type + Bromo adjacent homology (BAH) domain + Translation elongation factor EFTs/EF1B, dimerisation + DDT domain + Phosphodiester glycosidase + Leucyl/phenylalanyl-tRNA-protein transferase + UDP-glucuronosyl/UDP-glucosyltransferase + Glycerol-3-phosphate dehydrogenase, NAD-dependent + Pyridine nucleotide-disulphide oxidoreductase, class-II, active site + Renal dipeptidase family + Uncharacterised protein family Ycf49 + Calreticulin/calnexin + Actinin-type actin-binding domain, conserved site + Beta-hexosaminidase, eukaryotic type, N-terminal + Protein translocase subunit SecA + Peptidase M1, alanyl aminopeptidase, Ig-like fold + Oleate hydratase + Cytochrome ubiquinol oxidase subunit 1 + Orotidine 5'-phosphate decarboxylase, active site + Ribonucleotide reductase small subunit family + HORMA domain + Prefoldin alpha-like + Electron transfer flavoprotein, alpha subunit, C-terminal + Peptidase M24A, methionine aminopeptidase, subfamily 1 + Helicase-associated + Uncharacterised domain UPF0126 + MoeA, C-terminal, domain IV + Cytochrome c oxidase assembly protein CtaG/Cox11, domain + Somatomedin B domain + Pyrroline-5-carboxylate reductase, dimerisation domain + Transcriptional regulator TACO1-like + MOSC, N-terminal beta barrel + Uncharacterised protein family UPF0753 + Ribosomal protein L27 + Uncharacterised domain YOR215C, mitochondrial + KDPG/KHG aldolase + Flavodoxin-like fold + CidB/LrgB family + SAICAR synthetase, conserved site + VDE lipocalin domain + Phosphoglucose isomerase, conserved site + RQC domain + MnmE, helical domain + Phosphoenolpyruvate carboxykinase, N-terminal + Lactate/malate dehydrogenase, N-terminal + APOBEC-like, N-terminal + Arginine biosynthesis protein ArgJ + Tetrahydrofolate dehydrogenase/cyclohydrolase + Glucosidase II beta subunit, N-terminal + Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain + TerD domain + Threonine-tRNA ligase, class IIa + Small protein B + Roadblock/LAMTOR2 domain + Phosphatidylethanolamine-binding protein + UDP-glucose/GDP-mannose dehydrogenase, C-terminal + tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG + XPG conserved site + Fe-S metabolism associated domain, SufE-like + Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site + Glutamate synthase, central-N + TRAP transporter solute receptor, TAXI family + Bacteriophage phiJL001, Gp84, C-terminal + O-acyltransferase WSD1, C-terminal + DNA polymerase beta, thumb domain + Histone acetyltransferase Rtt109/CBP + Serine hydroxymethyltransferase, pyridoxal phosphate binding site + FeS cluster insertion, C-terminal, conserved site + NusG, N-terminal + Glycosyl transferase family 39/83 + 5-formyltetrahydrofolate cyclo-ligase + Penicillin/GL-7-ACA/AHL/aculeacin-A acylase + UbiE/COQ5 methyltransferase + Folylpolyglutamate synthetase + Ribosomal protein S18 + Translation elongation factor Ts, conserved site + Rpn11/EIF3F, C-terminal + CTLH/CRA C-terminal to LisH motif domain + LacI-type HTH domain + Dihydrodipicolinate reductase, N-terminal + MutL, C-terminal, dimerisation + Sterol-sensing domain + N-formylglutamate amidohydrolase + Vesicle transport v-SNARE, N-terminal + Dihydroorotase, conserved site + Pyruvate phosphate dikinase, PEP/pyruvate-binding + NmrA-like domain + Protein of unknown function with TPD sequence-motif + Arginine-tRNA ligase + Vitamin B12-dependent methionine synthase, activation domain + Ribosomal protein L19 + ATP synthase, F0 complex, subunit C + Beta-hydroxydecanoyl thiol ester dehydrase, FabA/FabZ + Integrase, N-terminal zinc-binding domain-like + Ribosomal protein S16 domain + Domain of unknown function DUF4457 + Pseudouridine synthase II, N-terminal + Protein of unknown function DUF2009 + 1,3-beta-glucan synthase subunit FKS1-like, domain-1 + DNAJ-containing protein, X-domain + DDH domain + AAA+ ATPase domain + Phenazine biosynthesis PhzF protein + ATPase, OSCP/delta subunit + Glycosyl transferase, family 4 + Transketolase binding site + Octanoyltransferase, conserved site + Ribosomal protein L6, conserved site + 50S ribosomal protein uL4 + Ferric reductase transmembrane component-like domain + Piwi domain + tRNA dimethylallyltransferase + Uncharacterised protein family UPF0047 + Zinc finger, UBP-type + Scaffold protein Nfu/NifU, N-terminal + 1, 4-beta cellobiohydrolase + Bacteriophage lambda, GpH, tail tape measure, C-terminal + Fructose-bisphosphate aldolase, class-II + Putative phage-type endonuclease + Elongation factor 4 + Galactosyltransferase, C-terminal + Uracil-DNA glycosylase family 1 + Bacterial bifunctional deaminase-reductase, C-terminal + Carbohydrate binding module family 20 + Citrate synthase-like, small alpha subdomain + Citrate synthase-like, large alpha subdomain + Domain of unknown function DUF3883 + Ferritin/DPS protein domain + Ribosomal protein S12, bacterial-type + tRNA-specific 2-thiouridylase + TadE-like + Topoisomerase C-terminal repeat + 3-dehydroquinate synthase domain + Bulb-type lectin domain + O-methyltransferase, family 3 + Sec23/Sec24, helical domain + ABC transporter Uup, C-terminal + Universal stress protein A + Ribosomal protein L18 + DNA polymerase, helix-hairpin-helix motif + FdhE-like + Moybdenum cofactor oxidoreductase, dimerisation + GLE1-like + IMP dehydrogenase / GMP reductase, conserved site + S-adenosyl-L-homocysteine hydrolase, conserved site + YABBY protein + GTPase Der, C-terminal KH-domain-like + Phosphoribosylglycinamide synthetase, conserved site + Amidase, conserved site + Histidinol dehydrogenase + ABA DEFICIENT 4-like + ATP-dependent helicase, C-terminal + Flavin monooxygenase-like + ABC transporter periplasmic binding domain + TGS-like domain + Prenylated rab acceptor PRA1 + Ribose-phosphate diphosphokinase + F1F0 ATP synthase OSCP/delta subunit, N-terminal domain + Translation elongation factor EFG/EF2 + Translation elongation factor EFTu/EF1A, bacterial/organelle + Major sperm protein (MSP) domain + V-ATPase proteolipid subunit + ATP synthase, alpha subunit, C-terminal + Protein of unknown function DUF1350 + Nuclear control of ATP synthase 2 + Peptidase M41, FtsH extracellular + 3-hydroxyisobutyrate dehydrogenase + Scramblase + Peptidase M50 + NADH-quinone oxidoreductase, subunit D + Glycoside hydrolase family 30 + Peptidyl-tRNA hydrolase, conserved site + Ribosome biogenesis protein BMS1/TSR1, C-terminal + Succinylglutamate desuccinylase/aspartoacylase + 5'-3' exonuclease, alpha-helical arch, N-terminal + 5'-3' exonuclease, C-terminal domain + LOG family + Guanylate kinase, conserved site + MnmG-related, conserved site + Ribosomal RNA adenine methylase transferase, conserved site + Cytochrome b/b6, C-terminal + Cytochrome b/b6, N-terminal + YrdC-like domain + THUMP domain + S-formylglutathione hydrolase + Protein kinase, C-terminal + Ribosomal protein L11, bacterial-type + Restriction endonuclease, type I, HsdS + Zinc finger, AN1-type + Phosphotyrosine protein phosphatase I superfamily + RNA polymerase, alpha subunit, C-terminal + ATP-dependent protease, HslV subunit + Superoxide dismutase, copper/zinc, binding site + Cyclin, C-terminal domain + LMBR1-like membrane protein + Methyltransferase TRM13 + Ribosomal protein L7/L12 + Zinc finger, RING-H2-type + NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminal + Ribosomal protein L9, C-terminal + Longin domain + Carbamoyl-phosphate synthase, small subunit + Ribonuclease II/R, conserved site + Aminotransferase, class IV, conserved site + Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal + Methylmalonyl-CoA mutase, alpha chain, catalytic + SsrA-binding protein + Beta-propeller repeat + DNA-directed DNA polymerase, family B, exonuclease domain + Tetratricopeptide TPR-4 + Ribosomal protein S2, conserved site + RNA polymerase subunit, RPB6/omega + Domain of unknown function DUF861, cupin-3 + 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III, C-terminal + Tetrapyrrole biosynthesis, uroporphyrinogen III synthase + Disulphide bond formation protein DsbB/BdbC + Dihydrolipoamide dehydrogenase + Aspartate carbamoyltransferase + Dihydroprymidine dehydrogenase domain II + Peptidase M24, C-terminal domain + Sodium/potassium/calcium exchanger + Zinc ribbon, NADH pyrophosphatase + Poly-beta-hydroxybutyrate polymerase, N-terminal domain + Domain of unknown function DUF4217 + MutY, C-terminal + Glycosyl hydrolase family 30, beta sandwich domain + Ornithine decarboxylase + Bacteriophage/Gene transfer agent portal protein + Glycosyl hydrolases family 1, N-terminal conserved site + DNA topoisomerase, type IA, zn finger + Ribosomal RNA adenine methyltransferase KsgA/Erm + Delta-aminolevulinic acid dehydratase + Ribosomal protein L17 + Glycoside hydrolase family 38, N-terminal domain + Glutathione synthase, alpha-helical, eukaryotic + Fructose-1,6-bisphosphatase class 2/Sedoheputulose-1,7-bisphosphatase + Ubiquitin conjugation factor E4, core + Rieske iron-sulphur protein, C-terminal + Orn/DAP/Arg decarboxylase 2, conserved site + Ribosomal protein L28 + Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal + Xaa-Pro dipeptidyl-peptidase-like domain + Zinc finger, FPG/IleRS-type + Protein of unknown function DUF2237 + 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase + 5'-Nucleotidase/apyrase + SecA preprotein, cross-linking domain + TRAM domain + Transcriptional regulator TACO1-like, domain 3 + Ribosomal protein L28/L24 + Deoxyxylulose-5-phosphate synthase + Cleavage/polyadenylation specificity factor, A subunit, C-terminal + Shikimate dehydrogenase substrate binding, N-terminal + 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain + Bacteriophage VT1-Sakai, H0018 + Phosphoribosyl-ATP pyrophosphohydrolase-like + Zinc finger, TAZ-type + Ribosomal protein L1, conserved site + Guanine nucleotide binding protein (G-protein), alpha subunit + ABC transporter permease MalE + Beta galactosidase small chain/ domain 5 + Septin-type guanine nucleotide-binding (G) domain + Protein of unknown function DUF465 + SecA Wing/Scaffold + Ribosomal protein L27, conserved site + HELP + Trigger factor, ribosome-binding, bacterial + DNA topoisomerase, type IA, active site + Nucleotide sugar epimerase + Peptidase S16, active site + SAICAR synthetase/ADE2, N-terminal + Glycosyl transferase, family 17 + Sec-independent protein translocase protein TatA/B/E + Poly A polymerase, head domain + Serine-tRNA ligase, type1 + Galactose-1-phosphate uridyl transferase, N-terminal + GPI mannosyltransferase + Ribosomal protein L3, conserved site + NADH:ubiquinone oxidoreductase, subunit 1/F420H2 oxidoreductase subunit H + Peptidase M28 + Ribosome maturation factor RimP, C-terminal + Hedgehog/Intein (Hint) domain + WLM domain + Tim44-like domain + S-adenosylmethionine:tRNA ribosyltransferase-isomerase, QueA + Carbamoyl-phosphate synthase small subunit, N-terminal domain + Riboflavin kinase domain + Ferrodoxin-fold anticodon-binding domain + Domain of unknown function DUF4203 + ATP synthase, F1 complex, gamma subunit conserved site + Protein-export membrane protein SecD/SecF, archaeal and bacterial + Protein of unknown function DUF268, Caenorhabditis species + Nucleoid-associated protein YbaB/EbfC family + Penicillin-binding protein, dimerisation domain + Copper type II, ascorbate-dependent monooxygenase, N-terminal + Amino acid/polyamine transporter 2 + TM2 domain + B9 domain + Dual-specificity RNA methyltransferase RlmN + Ribosomal protein S5, N-terminal, conserved site + Transcription factor 25 + Arginyl tRNA synthetase N-terminal domain + Zinc finger, TFIIS-type + Molybdopterin cofactor biosynthesis C (MoaC) domain + Protein of unknown function DUF112, transmembrane + Protein of unknown function DUF924 + Ribosomal protein S7, conserved site + Harbinger transposase-derived nuclease domain + Adenine nucleotide alpha hydrolase-like domains + mRNA (guanine-N(7))-methyltransferase domain + Ceramidase + Vacuolar protein sorting-associated protein 35 + Tricarboxylate/iron carrier + NAD(P) transhydrogenase, alpha subunit, C-terminal + Ribosomal protein S16 + Diaminopimelate epimerase, DapF + Protein of unknown function DUF411 + PLAC8 motif-containing protein + Glucokinase + Phosphotransferase KptA/Tpt1 + N-(5'phosphoribosyl) anthranilate isomerase (PRAI) + Condensation domain + Argininosuccinate lyase, C-terminal + Ribosomal protein L16 + ATP-grasp fold, ATP-dependent carboxylate-amine ligase-type + Dynamin GTPase effector + Molybdopterin dinucleotide-binding domain + NAD-dependent DNA ligase, adenylation + PH-BEACH domain + Ribosomal protein L14P, conserved site + Gamma interferon inducible lysosomal thiol reductase GILT + Putative zinc- or iron-chelating domain containing protein + Uncharacterised domain NUC173 + Phosphoglucose isomerase (PGI) + Probable peptidoglycan glycosyltransferase FtsW/RodA + Glycosyl transferase family 3, N-terminal domain + Diaminopimelate decarboxylase, LysA + Phytochelatin synthase + Cilia/flagella-associated protein 20/WDR90/C3orf67 + Ubiquinone biosynthesis protein Coq4 + DNA mismatch repair protein MutS, clamp + GroES chaperonin family + Trigger factor, C-terminal + Transmembrane protein 65 + Sigma-54 interaction domain, ATP-binding site 2 + Thymidine kinase + NADH:ubiquinone oxidoreductase, subunit 1, conserved site + Carboxylase, conserved domain + Ribosome-binding ATPase YchF/Obg-like ATPase 1 + DNA/pantothenate metabolism flavoprotein, C-terminal + Phage portal protein, HK97 + Galactokinase + 30s ribosomal protein S13, C-terminal + Vacuolar protein sorting-associated protein 54, N-terminal + Flavoprotein + Protein of unknown function DUF3119 + Protein patched/dispatched + Terminase large subunit, Lambdalikevirus-type + Kringle, conserved site + Beta-adaptin appendage, C-terminal subdomain + NTP pyrophosphohydrolase MazG, putative catalytic core + Polyribonucleotide nucleotidyltransferase, RNA-binding domain + Peptidase C13, legumain + Anoctamin, dimerisation domain + Smooth muscle protein/calponin + Fructose-2,6-bisphosphatase + Cytochrome c oxidase assembly protein CtaG/Cox11 + Initiation factor eIF-4 gamma, MA3 + PAP/25A-associated + Permease LptG/LptF-related + GidA associated domain 3 + Translation initiation factor aIF-2, bacterial-like + Acetate-CoA ligase + Ribosomal protein S4, conserved site + Carbohydrate-binding domain, family 9 + Molybdenum cofactor synthesis C-terminal + UvrC family homology region + Riboflavin kinase domain, bacterial/eukaryotic + Lipocalin/cytosolic fatty-acid binding domain + DNA topoisomerase, type IIA, subunit B + Glycoside hydrolase, family 28 + Glycoside hydrolase 38/57, N-terminal domain + Phosphoribosylglycinamide synthetase, N-terminal + Proline racemase family + ATP-grasp fold, succinyl-CoA synthetase-type + Ribosomal protein S3, C-terminal + Catalase core domain + Ribosomal protein L3, bacterial/organelle-type + Shikimate kinase/gluconokinase + Acyl-CoA dehydrogenase, N-terminal, bacteria + NET domain + Glutamate synthase, alpha subunit, C-terminal + PWI domain + Ferric-uptake regulator + SAC3/GANP/THP3 + 26S proteasome regulatory subunit P45-like + 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal + PHB de-polymerase, C-terminal + Wilm's tumour protein + Anthranilate synthase/para-aminobenzoate synthase like domain + Cupin 1 + Flagellar motor switch protein FliG, alpha-helical + ATP synthase, F1 complex, delta/epsilon subunit, N-terminal + Alcohol dehydrogenase class III + YCII-related + tRNA threonylcarbamoyl adenosine modification protein TsaE + Molybdopterin biosynthesis MoaE + Alpha-glycerophosphate oxidase, C-terminal + Transglycosylase SLT domain 2 + Ribosomal protein S19 conserved site + Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding + Galactokinase, conserved site + Glutathione S-transferases, class Zeta + Thiamin pyrophosphokinase, vitamin B1-binding domain + Ribosomal protein L21 + UvrB, YAD/RRR-motif-containing domain + Ribosomal protein L20 C-terminal domain + SAF domain + Ribosomal RNA adenine dimethylase + Nitrite/sulphite reductase 4Fe-4S domain + Ribose 5-phosphate isomerase, type A + P-type ATPase, C-terminal + Translation initiation factor 3, N-terminal + 3-oxoacid CoA-transferase, subunit B + Ribosomal protein L34 + Thiazole synthase ThiG + Tryptophan-tRNA ligase + Leucine-tRNA ligase + Ribose-phosphate pyrophosphokinase, N-terminal domain + Glycine cleavage system P protein + TonB, C-terminal + Gamma-glutamylcyclotransferase, AIG2-like + Peroxisomal biogenesis factor 11 + Integrase, SAM-like, N-terminal + Prephenate dehydratase + Phosphofructokinase domain + Alpha-L-rhamnosidase, six-hairpin glycosidase domain + DNA-binding protein Dps + Calreticulin/calnexin, conserved site + Transcription regulator Rrf2-type, conserved site + Rho GDP-dissociation inhibitor domain + Domain of unknown function DUF4200 + RNA methyltransferase RlmH + Queuosine precursor transporter + D-galactoside/L-rhamnose binding SUEL lectin domain + Ketoacyl-synthetase, C-terminal extension + Polyhydroxyalkanoate depolymerase + Plasmid maintenance toxin/Cell growth inhibitor + Queuosine biosynthesis protein QueC + CH-like domain in sperm protein + C-terminal of Roc (COR) domain + Inositol monophosphatase, SuhB + Type III secretion system inner membrane P protein + Phosphoribosyl-ATP pyrophosphohydrolase + Barrier- to-autointegration factor, BAF + Histidine biosynthesis, HisF + S-adenosylmethionine synthetase, central domain + S-adenosylmethionine synthetase, N-terminal + Anthranilate synthase component I-like + Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y + Arginine-tRNA-protein transferase, C-terminal + NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site + Zf-FLZ domain + Transient receptor potential channel, canonical + Heavy metal-associated domain, copper ion-binding + Protein of unknown function DUF778 + Glycoside hydrolase, family 2, active site + rRNA small subunit methyltransferase G + tRNA-guanine transglycosylase + DNA polymerase III, alpha subunit + HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase + Ras GTPase-activating protein + Porphobilinogen deaminase, dipyrromethane cofactor binding site + 3-keto-5-aminohexanoate cleavage enzyme + Intradiol ring-cleavage dioxygenase, core + Malic enzyme, conserved site + Molybdenum cofactor biosynthesis protein A + Fagellar hook-basal body protein, FlgE/F/G + Protein of unknown function DUF885 + Adenylyl-sulfate kinase + Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal + DNA mismatch repair protein family + Domain of unknown function DUF4476 + Ribosomal protein L22, bacterial/chloroplast-type + Na+/H+ antiporter NhaA + Translation Initiation factor eIF- 4e + Protein-export membrane protein SecD/SecF/SecDF, conserved site + DNA polymerase family X + Asp/Glu/hydantoin racemase + Glycine-tRNA ligase, beta subunit + WASH complex, subunit strumpellin + Thymidylate synthase + Small multidrug resistance protein family + Alkaline phosphatase + SAM-dependent methyltransferase TRM5/TYW2-type + Copper chaperone PCuAC + Cytochrome c-type biogenesis protein CcmC + Glycoside hydrolase, family 2 + Cell division protein ZapA-like + Zinc finger/thioredoxin putative + Adenylyl cyclase class-4/guanylyl cyclase, conserved site + Cytochrome c oxidase subunit II-like C-terminal + VPLPA-CTERM protein sorting domain + Exportin/Importin, Cse1-like + COQ9 + 3-dehydroquinate synthase AroB + ABC transporter, TroCD-like + Adenosylcobalamin biosynthesis, ATP:cob(I)alamin adenosyltransferase-like + Ribosomal protein L35, non-mitochondrial + Bacterial protein export chaperone SecB + Ketopantoate hydroxymethyltransferase + NADAR + AAA C-terminal domain + Ribosomal protein S4, bacterial-type + Restriction endonuclease, type I, HsdR + IstB-like ATP-binding protein + PLAT/LH2 domain + Flagellin, D0/D1 domain + Dihydrodipicolinate reductase, C-terminal + Type III pantothenate kinase + Phosphatidate cytidylyltransferase + Cytidylyltransferase IspD/TarI + Zinc-finger binding domain of transposase IS66 + D-alanine--D-alanine ligase, N-terminal domain + Ribosomal protein S14, conserved site + Ku70/Ku80 beta-barrel domain + ERCC4 domain + Diacylglycerol glucosyltransferase, N-terminal + Type II/III secretion system + 14-3-3 domain + Zinc knuckle CX2CX3GHX4C + Protein of unknown function DUF3387 + tRNA N6-adenosine threonylcarbamoyltransferase, TsaD + FMN-dependent alpha-hydroxy acid dehydrogenase, active site + Protein of unknown function DUF2505 + NAD-glutamate dehydrogenase + Pantoate-beta-alanine ligase + IrrE N-terminal-like domain + Protein of unknown function DUF1013 + Anthranilate synthase component I, N-terminal + UbiE/COQ5 methyltransferase, conserved site + RimM protein + Ribosomal protein L32p + Amidophosphoribosyltransferase + Galactose-1-phosphate uridyl transferase, C-terminal + Uracil-DNA glycosylase, active site + Glycoside hydrolase, family 5, conserved site + Sterol reductase, conserved site + Prokaryotic N-terminal methylation site + DNA topoisomerase I, catalytic core, eukaryotic-type + La protein, RNA-binding domain + Cell wall hydrolase, SleB + Guanine nucleotide exchange factor, N-terminal + GDP-mannose 4,6-dehydratase + Protohaem IX farnesyltransferase + Uroporphyrinogen decarboxylase HemE + Orotidine 5'-phosphate decarboxylase + Biosynthetic peptidoglycan transglycosylase + MoeA, N-terminal and linker domain + Store-operated calcium entry regulator STIMATE/YPL162C + PROCN domain + Chromosomal replication initiator protein DnaA + Acetyl-CoA carboxylase carboxyl transferase, beta subunit + tRNA (pseudouridine(54)-N(1))-methyltransferase, TrmY + Replication factor C, C-terminal + Bile acid:sodium symporter/arsenical resistance protein Acr3 + Tyrosine-tRNA ligase + Importin-alpha, importin-beta-binding domain + 3-isopropylmalate dehydratase, small subunit + Glycoside hydrolase, family 45 + DXP reductoisomerase C-terminal domain + Hydroxymethylglutaryl-coenzyme A synthase, N-terminal + Glycoside hydrolase, family 42, N-terminal + dTDP-4-dehydrorhamnose 3,5-epimerase-related + P2X purinoreceptor + Galactose-1-phosphate uridyl transferase, class I + Glutathione-specific gamma-glutamylcyclotransferase + Calcium-dependent channel, 7TM region, putative phosphate + GTP-binding protein Era + Cobalamin biosynthesis protein CobT VWA domain + Cobalamin (vitamin B12)-binding module, cap domain + PepSY domain + tRNA-splicing ligase, RtcB + KH domain, NusA-like + Pheromone shutdown, TraB + Thymidine kinase, conserved site + Magnesium transporter, MgtE intracellular domain + Translation initiation factor IF-2, N-terminal + Arsenate reductase-like + FAM91, N-terminal domain + Cytochrome c1 + PEP-utilising enzyme, conserved site + Diaminopimelate epimerase, active site + Uncharacterised protein family CoxE-like + Peptidase S8, subtilisin, His-active site + FANCL C-terminal domain + Peroxidases heam-ligand binding site + Ubiquinone biosynthesis protein COQ9 + Cysteinyl-tRNA synthetase/mycothiol ligase + Radial spokehead-like protein + Fatty acid synthesis PlsX protein + Pseudouridine synthase I, TruA + Carbohydrate-binding WSC + Spermidine synthase, tetramerisation domain + Formate dehydrogenase accessory protein + Zinc finger, DNL-type + Cell shape determining protein MreB + Protein SCAI + Protein of unknown function DUF4170 + GTP cyclohydrolase N-terminal + ATP-dependent RNA helicase HrpB, C-terminal + Dehydroquinase, class II + Thiamine phosphate synthase + Ribosomal protein L36 + Peptidyl-tRNA hydrolase, PTH2 + THO complex, subunitTHOC2, C-terminal + SprT-like + GcrA cell cycle regulator + Glycosyl hydrolase family 38, C-terminal + S-adenosyl-L-methionine-dependent methyltransferase, MraW, recognition domain + Na/H antiporter domain + 3'5'-cyclic nucleotide phosphodiesterase, conserved site + Vacuolar protein sorting-associate protein Vta1/Callose synthase, N-terminal domain + Argininosuccinate lyase + CCAAT-binding factor + WHIM1 domain + Ornithine/putrescine carbamoyltransferase + rRNA-processing arch domain + SH3-like domain, bacterial-type + Indole-3-glycerol phosphate synthase, conserved site + ATP synthase, F1 complex, delta/epsilon subunit + Annexin + ATP-citrate lyase/succinyl-CoA ligase, active site + Surfeit locus 1/Shy1 + Undecaprenyl-diphosphatase UppP + 1-deoxy-D-xylulose 5-phosphate reductoisomerase + Ribosomal protein L7Ae/L8/Nhp2 family + Twin-arginine translocation pathway, signal sequence, bacterial/archaeal + CRC domain + GMP synthase, glutamine amidotransferase + PRP8 domain IV core + Aromatic amino acid hydroxylase + D-serine dehydratase-like domain + Ribosomal protein L29/L36 + Domain of unknown function DUF2828 + Chorismate synthase + N-acetyl-gamma-glutamyl-phosphate reductase, type 2 + Imidazole glycerol phosphate synthase, subunit H + Mre11, DNA-binding + Endonuclease V + Na+/H+ antiporter, NhaC-like, C-terminal + Quinone oxidoreductase/zeta-crystallin, conserved site + DNA recombination-mediator protein A + Chaperone DnaK + Chaperone DnaJ + RUN domain + PHP domain + Glycoside hydrolase, family 37 + Ribosomal protein L15, conserved site + Metalloprotease TldD/PmbA, N-terminal domain + Ribosomal protein L16, conserved site + Selenoprotein, Rdx type + GMP phosphodiesterase, delta subunit + CDC48, N-terminal subdomain + Protein of unknown function DUF229 + 1-deoxy-D-xylulose 5-phosphate reductoisomerase, C-terminal + Isoprenylcysteine carboxyl methyltransferase + Sphingolipid delta4-desaturase, N-terminal + NAD(P)H-quinone oxidoreductase subunit D/H + Glutamine synthetase, N-terminal conserved site + MmgE/PrpD + Protein DA1-like + Ribosomal protein L18, bacterial-type + Domain of unknown function DUF2263 + Biotin synthase/Biotin biosynthesis bifunctional protein BioAB + 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK + Pyrimidine 5'-nucleotidase, eukaryotic + GTP-binding protein TypA + Replication termination factor 2, RING-finger + Peptidase S46 + Peptide chain release factor 3, C-terminal + PTR2 family proton/oligopeptide symporter, conserved site + Dynein regulatory complex protein 1, C-terminal + YcnI-like + Protein of unknown function DUF2141 + Peptidoglycan biosynthesis protein MurJ + Adenine deaminase C-terminal domain + Casein kinase II, regulatory subunit, alpha-helical + NADH dehydrogenase, subunit C + TNFR/NGFR cysteine-rich region + Aspartate kinase, conserved site + Orthogonal Bundle domain in ATP12 + Methyladenine glycosylase + Serine incorporator/TMS membrane protein + Arp2/3 complex subunit 2/4 + Potassium channel, inwardly rectifying, Kir + NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site + HemN, C-terminal + Biotin and thiamin synthesis-associated domain + Ubiquinone biosynthesis O-methyltransferase + SUF system FeS cluster assembly, SufB + FeS cluster assembly SUF system, ATPase SufC + Exonuclease VII, large subunit, C-terminal + Cytochrome c-type biogenesis protein CcmF, C-terminal + NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 + Syntaxin, N-terminal domain + Protein FAM221A/B + Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain + 4-hydroxy-tetrahydrodipicolinate synthase, DapA + Uncharacterised protein family UPF0093 + Putative sodium bile acid cotransporter + Transcription elongation factor, GreA/GreB, N-terminal + Phosphorylated adapter RNA export protein, RNA-binding domain + Ureidoglycolate lyase domain + Prohibitin + Nicotinate phosphoribosyltransferase family + Transport protein particle (TRAPP) component + Glycosyl hydrolase family 63, C-terminal + UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal + 2-oxoglutarate dehydrogenase E1 component + KDPG/KHG aldolase, active site 2 + 3-oxoacyl-[acyl-carrier-protein] synthase 2 + HTH domain AraC-type, conserved site + Tagatose-6-phosphate kinase/1-phosphofructokinase N-terminal domain + Tex-like protein, HTH domain + Uncharacterised domain CHP00451 + Glutamate-tRNA ligase, bacterial/mitochondrial + Phenylalanyl-tRNA synthetase, class IIc, alpha subunit + SPOC-like, C-terminal domain + Transposase, IS111A/IS1328/IS1533, N-terminal + UDP-3-O-acyl N-acetylglucosamine deacetylase, N-terminal + Acyl-CoA desaturase + Domain of unknown function DUF547 + P-type trefoil domain + DeoC/FbaB/ lacD aldolase + Transcription termination factor NusA, C-terminal duplication + Root UVB sensitive family + Glutaminyl-peptide cyclotransferase + DNA polymerase family X, beta-like + 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, conserved site + Cysteine oxygenase/2-aminoethanethiol dioxygenase + Conserved hypothetical protein CHP02302, transmembrane + Protein of unknown function DUF760 + Putative S-adenosyl-L-methionine-dependent methyltransferase + NAD-dependent DNA ligase, OB-fold + 4-hydroxy-3-methylbut-2-enyl diphosphate reductase + Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase A + Phosphoribosyl-AMP cyclohydrolase domain + V-type ATPase, V0 complex, 116kDa subunit family + Phosphoserine phosphatase, domain 2 + 3-phosphoshikimate 1-carboxyvinyltransferase, conserved site + Phosphate transport system protein PhoU + Proline iminopeptidase + Lumazine-binding domain + Putative membrane protein insertion efficiency factor + Triacylglycerol lipase + DHHA2 domain + Solute-binding family 1 + NADH-quinone oxidoreductase subunit E-like + Sugar fermentation stimulation protein + Armet protein + Heat shock protein DnaJ, cysteine-rich domain + Lipin/Ned1/Smp2 (LNS2) + Inner membrane protein YebE + Bystin + Cobalt chelatase, CobT subunit + P-type ATPase, subfamily IIIA + TPM domain + Ribosomal protein L5, conserved site + Bacteriophage SPP1, head-tail adaptor + Ferrochelatase, active site + Galactose-1-phosphate uridyl transferase, class I His-active site + RST domain of plant C-terminal + Heat shock protein Hsp90, conserved site + Histone H4, conserved site + Type II pantothenate kinase + Proteinase inhibitor I78 + 60S ribosomal protein L6E + tRNA pseudouridylate synthase B, C-terminal + Ribosomal protein L9, bacteria/chloroplast + DAHP synthetase I/KDSA + 2-oxoglutarate dehydrogenase E1 component, N-terminal domain + ATP synthase, F0 complex, subunit A, active site + Integral membrane protein TerC, riboswitch-linked + Valyl-tRNA synthetase, tRNA-binding arm + Protein-lysine N-methyltransferase Efm5 + Ribonucleotide reductase, class I , alpha subunit + Acetyl-coenzyme A transporter 1 + Actin/actin-like conserved site + GxGYxYP putative glycoside hydrolase, N-terminal + Phosphotyrosyl phosphatase activator, PTPA + Aspartate-semialdehyde dehydrogenase, beta-type + Domain of unknown function DUF304 + Sialate O-acetylesterase domain + Domain of unknown function DUF306, Meta/HslJ + 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial-type + MgsA AAA+ ATPase C-terminal + Argininosuccinate synthase + Protein of unknown function DUF1517 + Plant ascorbate peroxidase + Carbamoyl-phosphate synthase, large subunit + Hydroxymethylglutaryl-CoA reductase, class I/II + Sarcosine oxidase subunit beta + Sarcosine oxidase, delta subunit, heterotetrameric + Glutamate/phenylalanine/leucine/valine dehydrogenase + Senescence marker protein-30 (SMP-30) + Glycosyl transferase, family 13 + Transposase InsH, N-terminal + Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain + Polyphosphate kinase N-terminal domain + Succinate dehydogenase/fumarate reductase N-terminal + Domain of unknown function DUF5127 + Myo-inositol-1-phosphate synthase, GAPDH-like + Sec39 domain + RNA polymerase sigma factor 70, region 4 type 2 + PurE domain + Cytochrome c-type biogenesis protein CcmF + Cytochrome c-type biogenesis protein + Hypoxia induced protein, domain + NADH-ubiquinone oxidoreductase, 20 Kd subunit + NADH:ubiquinone oxidoreductase-like, 20kDa subunit + Conserved hypothetical protein CHP02058 + Plus-3 domain + Peptidase T1A, proteasome beta-subunit + Peptidase T2, asparaginase 2 + Translation initiation factor 3 + ATP-citrate lyase/succinyl-CoA ligase, conserved site + Transcriptional coactivator/pterin dehydratase + GTP-binding protein TrmE, N-terminal + Transmembrane secretion effector + Pyridoxal phosphate homeostasis protein + Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex + Isocitrate lyase + Dihydrolipoamide succinyltransferase + Cytochrome c, class IC + Cation transporter + DNA polymerase type-Y, HhH motif + Atypical Arm repeat + Succinate dehydrogenase/fumarate reductase iron-sulphur protein + NADH pyrophosphatase-like, N-terminal + Fumarylacetoacetase, N-terminal + Transposase-like, Mu, C-terminal + Ribosomal protein L24/L26, conserved site + Acetylglutamate kinase + Thymidylate kinase, conserved site + S-adenosylmethionine synthetase, C-terminal + S-adenosylmethionine synthetase, conserved site + Ribosomal protein S13, bacterial-type + Ribosomal protein S11, bacterial-type + Peptidase M18 + Ubiquitin/SUMO-activating enzyme E1 + Transcriptional regulator PAI 2-type + RNA polymerase, subunit omega/K/RPB6 + FUN14 + Mandelate racemase/muconate lactonizing enzyme, conserved site + Caudovirus, tape measure, N-terminal + Methyl-CpG DNA binding + XdhC- CoxI + Tim10/FAM136A-like domain + CENP-T/Histone H4, histone fold + Terminase, large subunit gp17-like + DNA ligase, ATP-dependent + Fumarate reductase/succinate dehydrogenase, FAD-binding site + Ribosomal protein S19, bacterial-type + UDP-3-O-acyl N-acetylglucosamine deacetylase + CTP synthase + Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 + Orn/DAP/Arg decarboxylase 2, pyridoxal-phosphate binding site + Tetratricopeptide repeat-like domain + MoaA/nifB/pqqE, iron-sulphur binding, conserved site + Virulence factor BrkB + Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ + 3-oxoacyl-(acyl-carrier-protein) reductase + Cytochrome C oxidase subunit II, transmembrane domain + Type III secretion system FHIPEP + Transposase, IS66 + Peptidase S49, N-terminal proteobacteria + Carbohydrate kinase, predicted, conserved site + ATP:cob(I)alamin adenosyltransferase, PduO-type + Phospholipase C, phosphatidylinositol-specific, Y domain + PhoH-like protein + Polysaccharide export protein + OsmC/Ohr family + Ribosomal protein L35 + Intradiol ring-cleavage dioxygenase, C-terminal + Protein of unknown function DUF938 + Exopolysaccharide biosynthesis protein YbjH + Glutathione peroxidase active site + Histone H2A, C-terminal domain + Phosphoglucose isomerase, C-terminal + Metalloprotease catalytic domain, predicted + Ribosomal protein S7, bacterial/organellar-type + Ribosomal protein S5, bacterial-type + Concentrative nucleoside transporter N-terminal domain + Histidinol-phosphate aminotransferase family + NADH-quinone oxidoreductase, chain I + YjeF N-terminal domain + Thymidylate kinase + Phosphoglycerate kinase, conserved site + RarD protein + Ammonium transporter + Protein translocase complex, SecE/Sec61-gamma subunit + GTPase HflX + Transglycosylase-associated protein + 1-deoxy-D-xylulose 5-phosphate reductoisomerase, N-terminal + Potassium channel, inwardly rectifying, Kir, cytoplasmic + Translation elongation factor, IF5A C-terminal + Rho termination factor, RNA-binding domain + Rho termination factor, N-terminal + Ribosomal protein L33, conserved site + Ribosomal protein L35, conserved site + Ribosomal protein S10, conserved site + Ribosomal protein S13, conserved site + Josephin domain + Dihydroneopterin aldolase/epimerase domain + Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase + Domain of unknown function DUF1279 + GspD/PilQ family + Domain of unknown function DUF155 + Allosteric substrate binding domain + Guanylate-binding protein, C-terminal + Small-subunit processome, Utp12 + DNA polymerase beta, palm domain + Reductase, C-terminal + Protein-tyrosine phosphatase SIW14-like, eukaryotic + ELMO domain + Twin-arginine translocation protein TatB-like + RTX secretion protein D, Gram-negative bacteria + Glycyl-tRNA synthetase + Domain of unknown function DUF4033 + Prephenate dehydratase, conserved site + Flavin transferase ApbE + Nitrilotriacetate monooxygenase component A/pristinamycin IIA synthase subunit A + Thiamin pyrophosphokinase, catalytic domain + Putative fluoride ion transporter CrcB + Transcription elongation factor, GreA/GreB, C-terminal + Ubiquinol-cytochrome c reductase, iron-sulphur subunit + Cobalamin-dependent methionine synthase + Palmitoyl protein thioesterase + Inositol phosphatase + Ribosomal protein L24 + Domain of unknown function DUF4205 + Leucyl-tRNA synthetase, editing domain + Transposase, mutator type + Polyphosphate kinase-2-related + RNA polymerase sigma factor 70, region 1.1 + Schiff base-forming aldolase, active site + Schiff base-forming aldolase, conserved site + C-terminal-processing peptidase S41A + Nitrogen regulatory protein P-II, urydylation site + Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain + Ribosomal protein L6, bacterial-type + Protein of unknown function DUF2254, membrane + CobN/magnesium chelatase + Oligosaccharyl transferase, STT3 subunit + Nitrite/sulphite reductase iron-sulphur/sirohaem-binding site + Putative phage terminase, small subunit, P27 family + Phosphatidylserine decarboxylase-related + Argininosuccinate synthase, conserved site + RNA-binding domain, S1, IF1 type + Ureohydrolase, manganese-binding site + ATP phosphoribosyltransferase, conserved site + Putative GTP-binding controlling metal-binding domain + ATP-cone domain + Glycine cleavage system H-protein/Simiate + 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase + Ribulose bisphosphate carboxylase, large subunit, C-terminal + Copper type II ascorbate-dependent monooxygenase, C-terminal + Protein of unknown function DUF616 + EH domain-containing protein, N-terminal + GTP cyclohydrolase I domain + rRNA adenine dimethylase-like + HI0933 insert-like domain + P25-alpha + Nop domain + TRAP transporter permease protein + Pyrroline-5-carboxylate reductase + 14-3-3 protein + Peptidase M16C associated + Endonuclease III-like, iron-sulphur cluster loop motif + Hydroxyacylglutathione hydrolase + DEK, C-terminal + Glycosyl transferase, family 19 + GDP dissociation inhibitor + Translin-associated factor X-interacting protein 1, N-terminal + Peptidase M75, Imelysin + Cullin protein, neddylation domain + EVE domain + Protein of unknown function DUF1917 + Anthrax toxin, edema factor, central + Tim10-like + Tryptophan 2,3-dioxygenase + Prokaryotic glutathione synthetase, ATP-binding + Acetyl-CoA biotin carboxyl carrier + Phosphoribosylglycinamide synthetase + C-methyltransferase + Esterase, PHB depolymerase + PA domain + Tryptophan synthase, beta chain, conserved site + Tryptophan synthase, beta chain + Glycosyl transferase, family 11 + DNA-directed RNA polymerase, alpha subunit + FtsK gamma domain + DhaK domain + GPN-loop GTPase + GMP synthase, C-terminal + Methylmalonyl-CoA mutase, C-terminal + NADH:ubiquinone/plastoquinone oxidoreductase, chain 6 + Sulphate adenylyltransferase catalytic domain + POTRA domain, BamA/TamA-like + Glycine cleavage system H-protein, subgroup + Nitrogen regulatory protein PII + Lumazine/riboflavin synthase + Phospho-N-acetylmuramoyl-pentapeptide transferase, conserved site + Protein of unknown function DUF3593 + Ribosomal protein L30, ferredoxin-like fold domain + ER lumen protein retaining receptor + Acyl-CoA dehydrogenase, C-terminal domain + Ctr copper transporter + cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain + ER membrane protein complex subunit 1, C-terminal + Endoplasmic reticulum resident protein 29, C-terminal + ATP12, ATP synthase F1-assembly protein + AP180 N-terminal homology (ANTH) domain + PepSY-associated TM protein + Formyl transferase, C-terminal + Protein Iojap/ribosomal silencing factor RsfS + Hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase + Pyrophosphate-energised proton pump + Casein kinase II, regulatory subunit + RNA polymerase Rpb7, N-terminal + UvrD-like helicase C-terminal domain + Glycosyltransferase WbsX + Autophagy-related protein 27 + YHYH domain + Peptidase M17, leucyl aminopeptidase, N-terminal + tRNA-dihydrouridine synthase, putative, C-terminal + RNA 2-O ribose methyltransferase, substrate binding + Concentrative nucleoside transporter C-terminal domain + Cdc37, C-terminal + Peptide chain release factor 2 + PLAA family ubiquitin binding, PFU + Phosphoribosylaminoimidazole-succinocarboxamide synthase + RidA, conserved site + Octanoyltransferase + Ferredoxin [2Fe-2S], plant + Domain of unknown function DUF676, lipase-like + Acyl carrier protein (ACP) + Intracellular septation protein A + Protein of unknown function DUF45 + HNH endonuclease 5 + Parkin co-regulated protein + Dipeptide/tripeptide permease + Protein of unknown function DUF3141 + Heat shock protein Hsp33, N-terminal + DNA polymerase alpha/epsilon, subunit B + Peptidase M10 serralysin, C-terminal + Translation elongation factor P/YeiP, conserved site + Uroporphyrin-III C-methyltransferase + Phytase-like domain + Ribbon-helix-helix domain + PhoU domain + Uncharacterised conserved protein UCP032146 + Molybdenum cofactor biosynthesis, conserved site + D-alanine--D-alanine ligase/VANA/B/C, conserved site + Glycine-tRNA ligase, alpha subunit + YgfZ/GcvT conserved site + NADH-quinone oxidoreductase, chain M/4 + Yip1 domain + Voltage-dependent calcium channel, alpha-1 subunit + Neurotransmitter-gated ion-channel transmembrane domain + Imidazoleglycerol-phosphate dehydratase, conserved site + Peptidyl-tRNA hydrolase II domain + NADH-plastoquinone oxidoreductase, chain 5 subgroup + Cryptochrome/DNA photolyase class 1, conserved site, C-terminal + Cell division protein FtsZ + Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain + Argininosuccinate synthetase, catalytic/multimerisation domain body + CsbD-like domain + Neutral/alkaline non-lysosomal ceramidase, N-terminal + Myotubularin-like phosphatase domain + Imidazoleglycerol-phosphate dehydratase + Glutathione synthase, substrate-binding, eukaryotic + Coproporphyrinogen III oxidase, oxygen-independent related + Peptidase A22A, presenilin + Histidine-tRNA ligase + Cysteine-tRNA ligase + Acetohydroxy acid isomeroreductase C-terminal + Cysteine desulfurase, SufS + Uncharacterised protein family Ycf20 + Pseudouridine synthase, RluC/RluD + Protein of unknown function DUF1468 + Domain of unknown function DUF4965 + Glycosyl hydrolase, family 13, catalytic domain + Endoribonuclease YbeY, conserved site + Chorismate synthase, conserved site + Enkurin domain + Molybdenum cofactor biosynthesis C + SAC domain + DC1 + Lysine-specific demethylase-like domain + Methyltransferase putative zinc binding domain + PFTB repeat + Stress responsive alpha-beta barrel + RNA polymerase sigma factor 70, non-essential domain + SecY conserved site + GTP-binding protein, middle domain + SecA conserved site + CAP domain + Ribosomal protein L34, conserved site + Ribosomal protein L25 + Sarcosine oxidase, gamma subunit + CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase + Lumazine-binding protein + ABC transporter, FecCD-like + Chorismate mutase, bacteria + NADH ubiquinone oxidoreductase, F subunit + Glycoside hydrolase family 36 + Disulphide isomerase + ATP-dependent 6-phosphofructokinase + Endoribonuclease YbeY + Sec-independent periplasmic protein translocase TatC + Prepilin type IV endopeptidase, peptidase domain + Helix-turn-helix motif + Electron transfer flavoprotein, beta-subunit, conserved site + Coatomer, WD associated region + Outer membrane protein, OmpA-like, conserved site + Spindle pole body-associated protein Vik1/Cik1, microtubule binding domain + P-type ATPase, N-terminal + Tex protein, YqgF-like domain + ThiS, thiamine-biosynthesis + Molybdopterin converting factor, subunit 1 + Domain of unknown function DUF3506 + Solute-binding protein family 5, conserved site + Cytochrome c oxidase, subunit IV, bacterial aa3 type + Lysyl-tRNA synthetase, class II, C-terminal + Surfeit locus protein 2 + Homoserine dehydrogenase, conserved site + Carboxylesterase type B, conserved site + tRNA(Ile)-lysidine synthase, N-terminal + PB1 domain + YHS domain + Peptidase M12A + Phosphatidylinositol-specific phospholipase C, X domain + Ribosomal protein L25, beta domain + PRC-barrel domain + XdhC Rossmann domain + ATP-sulfurylase PUA-like domain + Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain + Fructose-1-6-bisphosphatase class I, N-terminal + Nitrate/nitrite sensing protein + Peptidase M15A, C-terminal + Lipoprotein SmpA/OmlA + SEP domain + Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal + PADR1 domain + Phosphoserine aminotransferase, Methanosarcina-type + Crossover junction endodeoxyribonuclease RuvC + AMP nucleosidase + Malate dehydrogenase, type 3 + Phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent + Ribosomal protein L30, bacterial-type + Inosine-5'-monophosphate dehydrogenase + Heat shock protein Hsp33, helix hairpin bin domain + Glycine zipper 2TM domain + Glycosyl hydrolases 36 + Stealth protein CR2, conserved region 2 + Polyphosphate kinase + Dihydroorotate dehydrogenase, conserved site + Phytochrome + Protein of unknown function DUF167 + Glycoside hydrolase, family 6, conserved site + Nudix hydrolase 6-like + Chloroquine-resistance transporter-like + Putative F0F1-ATPase subunit, Ca2+/Mg2+ transporter + tRNA nucleotidyltransferase/poly(A) polymerase, RNA and SrmB- binding domain + TonB box, conserved site + Aconitase/Iron-responsive element-binding protein 2 + Chromosomal replication control, initiator DnaA, conserved site + Solute-binding protein family 3, conserved site + Protein of unknown function DUF4838 + Ribosomal protein 50S-L18Ae/60S-L20/60S-L18A + Intimal thickness related receptor, IRP + Clathrin, heavy chain, linker, core motif + CBF1-interacting co-repressor CIR, N-terminal domain + Ribonuclease E/G + 3-oxoacyl-[acyl-carrier-protein] synthase 3 + Biotin-protein ligase, N-terminal + ABC-type uncharacterised transport system + Dihydrofolate reductase + ALIX V-shaped domain + Protein of unknown function DUF445 + Ribosomal RNA large subunit methyltransferase J + Membrane fusogenic activity + Pilus assembly, Flp-type CpaB + Sucrose-phosphatase-like, N-terminal + Glycine-rich domain-containing protein-like + Lipin, N-terminal + Alpha 1,4-glycosyltransferase domain + Adhesin B + BPG-independent PGAM, N-terminal + Glycoside hydrolase, family 2, conserved site + UvrABC system, subunit B + Actin-related protein 2/3 complex subunit 4 + Archaeal/bacterial/fungal rhodopsins + Lipase, GDXG, putative serine active site + Tail completion protein + Phospholipid biosynthesis protein, PlsX-like + Quinolinate phosphoribosyl transferase, N-terminal + Protein of unknown function DUF846, eukaryotic + Protein of unknown function DUF847 + Bacterial alpha-L-rhamnosidase N-terminal + Xaa-Pro dipeptidyl-peptidase, C-terminal + Transcription factor NusA, N-terminal + Segregation and condensation protein A + Exonuclease VII, small subunit + ABC transporter substrate-binding protein PnrA-like + NMD3 + Protein phosphatase inhibitor 2 (IPP-2) + Septum formation initiator FtsL/DivIC + Ada-like domain + Pre-mRNA processing factor 4 (PRP4)-like + Ribosomal RNA large subunit methyltransferase F-like + NADH-plastoquinone oxidoreductase, chain 5 + Ribonuclease PH, conserved site + Rab3 GTPase-activating protein catalytic subunit + Ketopantoate reductase, C-terminal domain + ATP synthase, F1 complex, beta subunit + Proline-tRNA ligase, class IIa, archaeal-type + Heat shock protein HslU + Adenylosuccinate lyase C-terminal + Quinolinate phosphoribosyl transferase, C-terminal + Urease accessory protein UreF + Peptidase S53, activation domain + Succinyl-CoA ligase, alpha subunit + Histone H5 + Ribosomal protein L34Ae + Alkylhydroperoxidase AhpD core + Putative exonuclease, DNA ligase-associated + TPP-binding enzyme, conserved site + Ring-hydroxylating dioxygenase beta subunit + Phosphatidylglycerol lysyltransferase, C-terminal + Phosphoribosylformylglycinamidine synthase subunit PurQ + BFD-like [2Fe-2S]-binding domain + S-adenosylmethionine synthetase + Molybdate transporter 1/2 + 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, conserved site + Phosphatidylinositol 3-kinase, C2 domain + Adenylosuccinate synthase, active site + Flp/Fap pilin component + Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase + Protein CHAPERONE-LIKE PROTEIN OF POR1-like + Domain of unknown function DUF1747 + Protein-(glutamine-N5) methyltransferase, release factor-specific + Glycoside hydrolase family 9 + RNA ligase domain, REL/Rln2 + GTP cyclohydrolase II, RibA + FANCI solenoid 2 domain + Protein of unknown function DUF2842 + Structure-specific recognition protein + Thiol:disulfide interchange protein DsbD, N-terminal domain + Ubiquitin-activating enzyme E1, four-helix bundle + Domain of unknown function DUF4496 + Ribonuclease II/ribonuclease R + ComEC/Rec2-related protein + Ribonucleotide reductase class II vitamin B12-dependent, N-terminal domain + Frag1/DRAM/Sfk1 + GTPase HflX, N-terminal + Phosphotransferase system, HPr histidine phosphorylation site + Ribosomal protein L25, long-form + Dihydrodipicolinate reductase, conserved site + Aconitase B, swivel + Ribosomal protein S24e + Nodulin-like + Putative member of DMT superfamily + 2-phosphoglycolate phosphatase, eukaryotic + DNA helicase, DnaB-like, N-terminal + DNA helicase, DnaB-like, C-terminal + DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type + Domain of unknown function DUF4470 + 3-hydroxybutyrate dehydrogenase + GRIM-19 + Ribosomal protein S18, conserved site + PEP-utilising enzyme, active site + Transthyretin/hydroxyisourate hydrolase, superfamily + OB-fold nucleic acid binding domain + tRNA (C5-cytosine) methyltransferase, NCL1 + Ketopantoate reductase, N-terminal domain + Nucleotidyl transferase AbiEii toxin, Type IV TA system + Proline dehydrogenase PutA, domain II + Proteasome activator pa28, C-terminal domain + D-arabinono-1,4-lactone oxidase + Ribosomal protein L24e-related + Cilia BBSome complex subunit 10 + 4Fe4S-binding SPASM domain + Holo-[acyl carrier protein] synthase + Myo-inositol-1-phosphate synthase + CYTH domain + Phage gp6-like head-tail connector protein + Ribosomal protein L22e + Cysteine synthase CysK + Glucosamine-fructose-6-phosphate aminotransferase, isomerising + Cysteine synthase + DNA polymerase III, beta chain + CofG family + Peptidase S58, DmpA + Peptidase S51 + Protein of unknown function DUF308, membrane + Zinc finger, MIZ-type + Drug resistance transporter EmrB/QacA subfamily + Acetylornithine/Succinylornithine transaminase family + GTP-binding protein EngA + PHA accumulation regulator DNA-binding, N-terminal + Ribosomal protein S21 + Major spike protein G + Transcription factor DP, C-terminal + Sulphur oxidation protein SoxZ + VRR-NUC domain + Signal transduction histidine kinase, HWE region + HPr kinase/phosphorylase, C-terminal + Protein SirB1, N-terminal + Sirohaem synthase, N-terminal + Translation elongation factor P + Protein of unknown function DUF983 + Dim1 family + Preprotein translocase YajC + Uncharacterised protein family UPF0060 + Ribosomal protein L19, conserved site + Adenosine deaminase/editase + Transcription-repair-coupling factor, C-terminal domain + Protein of unknown function DUF3422 + Transcription antitermination protein, NusG + USP8 dimerisation domain + DNA-directed DNA polymerase, family B, conserved site + Ribosomal protein S17e + Leu/Phe/Val dehydrogenases active site + Protein of unknown function DUF4586 + GAD domain + DNA polymerase beta-like, N-terminal domain + PspA/IM30 + Domain of unknown function DUF35, OB-fold, C-terminal + Pyridoxamine 5'-phosphate oxidase + Protein of unknown function DUF974 + Sulphate adenylyltransferase + Protein of unknown function DUF4432 + DNA topoisomerase I, DNA binding, mixed alpha/beta motif, eukaryotic-type + Domain of unknown function DUF1993 + ParB/RepB/Spo0J partition protein family + MOB kinase activator family + Azospirillum phage Cd, Gp10 + Ribosome maturation factor RimP, N-terminal + Zinc-ribbon domain + Phosphohydrolase-associated domain + Death on curing protein + Domain of unknown function DUF4040 + Ribosomal RNA methyltransferase, Spb1, C-terminal + Bacterial DNA recombination protein RuvA + Photosystem I PsaD + Adenylosuccinate synthase, GTP-binding site + General secretory system II, protein E, N-terminal + GTP cyclohydrolase I, conserved site + AP endonuclease 1, conserved site + Cobaltochelatase subunit CobS N-terminal domain + 26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1 + Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding + Na+/H+ antiporter subunit G + Serine dehydratase-like, alpha subunit + K+/H+ exchanger + Costars domain + tRNA threonylcarbamoyl adenosine modification protein TsaB + Glutamine synthetase type III N-terminal + Chromosomal replication initiator, DnaA C-terminal + Ribosomal protein L37ae/L37e + Spo11/DNA topoisomerase VI subunit A + Phosphomethylpyrimidine synthase + Transglutaminase-like cysteine peptidase, predicted + Autophagy-related protein 3 + Magnesium transporter MgtE + 10TM putative phosphate transporter, cytosolic domain + Cytochrome c oxidase, subunit I bacterial type + Arginine-tRNA-protein transferase, N-terminal + UDP-3-O-acyl N-acetylglucosamine deacetylase, C-terminal + ABC transporter, haem export, CcmA + Zinc finger, DksA/TraR C4-type conserved site + Recombination protein RecR, C4-type zinc finger + AGR-C-984p-like domain + Zinc finger, CHY-type + Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, B subunit + Tensin phosphatase, C2 domain + Stc1 domain + DnaA N-terminal domain + DNA replication/recombination mediator RecO, N-terminal + Orn/Lys/Arg decarboxylase, major domain + Ribosomal protein S17, conserved site + AARP2CN + Domain of unknown function DUF1730 + Calcium/calmodulin-dependent protein kinase II, association-domain + MINDY deubiquitinase domain + Programmed cell death protein 2, C-terminal + Thymidylate synthase ThyX + RadC protein + Penicillin-binding protein 2 + Fibronectin, type II, collagen-binding + TFIID subunit TAF5, NTD2 domain + Adhesion lipoprotein + Adenosylcobinamide-GDP ribazoletransferase + Domain of unknown function DUF202 + Sodium/solute symporter, conserved site + Protein-tyrosine phosphatase-like, PTPLA + Secretory protein YscJ/FliF + rRNA-processing protein Fcf1/Utp23 + TRAP transporter, 4TM/12TM fusion protein + DnaJ homologue, subfamily C, member 28, conserved domain + Domain of unknown function DUF1990 + VTC domain + Ubiquitin-activating enzyme E1, C-terminal + Phasin + Potassium channel, voltage dependent, Kv3.3 + Malate dehydrogenase, active site + Mannose-6-phosphate isomerase, type I + TMEM70 family + Domain of unknown function DUF3333 + CbxX/CfqX, monofunctional + KDPG/KHG aldolase, active site 1 + PDCD5-related protein + TIP49, C-terminal + Bacterial virulence + Peptidase S8, subtilisin, Asp-active site + SWIB/MDM2 domain + 6-pyruvoyl tetrahydropterin synthase/QueD family protein + Transposase, IS116/IS110/IS902 + Heat-inducible transcription repressor HrcA, C-terminal + Bacterial lipid A biosynthesis acyltransferase + ATPase, V1 complex, subunit D + Photosystem II Psb28, class 1 + CcmH/CycL/Ccl2/NrfF family + Nucleolar complex protein 2 + Preprotein translocase SecG subunit + Inhibitor of growth protein, N-terminal histone-binding + Histidine acid phosphatase active site + Domain of unknown function DUF2147 + Protein of unknown function DUF2155 + Acetolactate synthase, small subunit, C-terminal + Endonuclease III, iron-sulphur binding site + Ribosomal protein L7Ae conserved site + Nitric oxide synthase, N-terminal + Prolipoprotein diacylglyceryl transferase + Sodium:alanine symporter + Phosphoribosyl pyrophosphate synthetase, conserved site + SRCR-like domain + Tudor domain + Formate dehydrogenase iron-sulphur subunit, Proteobacteria + Formate dehydrogenase, gamma subunit + Kynurenine formamidase + Probable epoxyqueuosine reductase QueH + tRNA wybutosine-synthesizing protein + Colicin V production, CvpA + Glycoside hydrolase, family 24 + LD-carboxypeptidase A, C-terminal domain + Uncharacterised protein family, transmembrane-17 + Ribokinase + Succinate dehydrogenase, cytochrome b subunit, conserved site + SLC12A transporter, C-terminal + Multiple antibiotic resistance (MarC)-related + DNA/RNA-binding protein Alba-like + Prefoldin beta-like + B domain of TMEM189, localisation domain + Potentiating neddylation domain + Bifunctional kinase-pyrophosphorylase + Organic solute transporter subunit alpha/Transmembrane protein 184 + Phosphoribosylformylglycinamidine cyclo-ligase + DNA polymerase lambda, fingers domain + Polyphosphate kinase C-terminal domain + Domain of unknown function DUF2062 + ABC transporter phosphate permease PstC, N-terminal domain + Sec7, C-terminal + NADH-quinone oxidoreductase, chain G, C-terminal + Formate/nitrite transporter, conserved site + ATP:guanido phosphotransferase, N-terminal + Acetohydroxy acid isomeroreductase, NADPH-binding domain + FAD-binding 8 + Phenylalanine-tRNA ligase, class II, N-terminal + NOT2/NOT3/NOT5 + PAZ domain + BAG domain + SRA-YDG + Beta-galactosidase trimerisation + DNA sulphur modification protein DndB + UbiC transcription regulator-associated + Acetaldehyde dehydrogenase + Bacterial sugar transferase + Acetoacetate decarboxylase beta barrel domain + N-acetylmuramoyl-L-alanine amidase domain + Kre9/Knh1 family + DNA-directed RNA polymerase, RBP11-like dimerisation domain + Protein of unknown function DUF1153 + Flavinator of succinate dehydrogenase + Inner centromere protein, ARK-binding domain + SF-assemblin + Glycine oxidase ThiO + Alanine racemase + Fructose-bisphosphate aldolase, class II, yeast/E. coli subtype + Protein of unknown function DUF882 + MYCBP-associated protein + ATP synthase, F0 complex, subunit C, DCCD-binding site + Protein of unknown function DUF1476 + Histone acetyltransferase domain, MYST-type + Nascent polypeptide-associated complex NAC domain + FF domain + D-alanine--D-alanine ligase, C-terminal + Domain of unknown function DUF1977, DnaJ-like + SurA N-terminal + Guanylyl cyclase + Autophagy protein Atg8 ubiquitin-like + Acetaldehyde dehydrogenase, C-terminal + Kynureninase + Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain + Transcription initiation factor TAFII31 + Penicillin-binding protein, OB-like domain + Reticulon + Myxococcus cysteine-rich repeat + Conserved hypothetical protein CHP02231 + CbbQ/NirQ/NorQ, C-terminal + Ysc84 actin-binding domain + Bardet-Biedl syndrome 5 protein + YEATS + Pre-mRNA-splicing factor 38 + Catalase, mono-functional, haem-containing + Spindle assembly abnormal protein 6, N-terminal + Asn/Gln amidotransferase + P2X purinoreceptor extracellular domain + Ribonuclease PH, bacterial-type + Intraflagellar transport complex B protein 46 + KIF-1 binding protein + ARID DNA-binding domain + Conserved hypothetical protein CHP02186-related, transmembrane + Glycosyltransferase, GlcNAc + Phosphate-selective porin O/P + Inositol 1,4,5-trisphosphate/ryanodine receptor + Formate-tetrahydrofolate ligase, FTHFS + Histone H2B + NDUFAF3/Mth938 domain-containing protein + SWIRM domain + Zinc finger, HIT-type + Periplasmic copper-binding protein NosD, beta helix domain + Protein of unknown function DUF1285 + 5'(3')-deoxyribonucleotidase + 2-keto-3-deoxygluconate permease + DNA helicase, ATP-dependent, RecQ type, bacterial + Protein of unknown function DUF1491 + Coatomer beta subunit, appendage platform domain + NudC N-terminal domain + Protein of unknown function DUF2849 + RyR/IP3R Homology associated domain + Phage conserved hypothetical protein + Ureidoglycolate lyase + Peptidase M10, metallopeptidase + Biotin protein ligase, C-terminal + Stealth protein CR3, conserved region 3 + Stealth protein CR1, conserved region 1 + DNA helicase, Holliday junction RuvA type, domain I, bacterial + LIS1 homology motif + CheW-like domain + FtsK domain + Di-haem oxidoreductase, putative peroxidase + NADH-ubiquinone reductase complex 1 MLRQ subunit + YMGG-like Gly-zipper + DOMON domain + Nitrogen fixation protein FixH + DNA topoisomerase I, DNA binding, eukaryotic-type + CocE/Serine esterase + Fumarate hydratase, class II + 6-phosphogluconolactonase, DevB-type + Phosphate transport system permease protein 1 + D-alanine--D-alanine ligase + DNA repair protein RadA + Oligopeptide transporter, OPT superfamily + D-alanyl-D-alanine dipeptidase + Diacylglycerol kinase, accessory domain + Ribosomal protein L47, mitochondrial + Probable protein kinase UbiB + Protein of unknown function DUF4402 + H/ACA ribonucleoprotein complex, subunit Gar1/Naf1 + 3-deoxy-D-manno-octulosonic-acid transferase, N-terminal + Aconitase X catalytic domain, putative + Ribosomal protein S9, conserved site + Sigma 54 modulation/S30EA ribosomal protein, C-terminal + Metal-dependent protein hydrolase + Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site + Uncharacterised protein family UPF0324, prokaryote + Domain of unknown function DUF2083,transcriptional regulator + Uncharacterised domain SAYSvFN + FAE1/Type III polyketide synthase-like protein + Origin recognition complex, subunit 2 + Rod shape-determining protein MreC + Exonuclease VII, large subunit + TolB, N-terminal + Outer membrane protein assembly factor BamA + NusB antitermination factor + BRK domain + Lytic murein transglycosylase + Uncharacterised protein family UPF0149 + Tetraacyldisaccharide 4'-kinase + SAM-dependent methyltransferase RsmI, conserved site + Ubiquitin activating enzyme, alpha domain + Fructose-1,6-bisphosphatase + Peptidase C45 + Uncharacterised conserved protein UCP030820 + Toxic anion resistance + N-acetyltransferase RimI/Ard1 + Chloroplast protein import component Tic20 + Aspartate-tRNA ligase, type 1 + Toxin-antitoxin system, RelE/ParE toxin family + Cell morphogenesis protein N-terminal + Protein of unknown function DUF3754 + Transcription initiation factor TFIID subunit 1, domain of unknown function + Glu-tRNAGln amidotransferase C subunit + Glycoside hydrolase, family 39 + Cytochrome c/c1 haem-lyase + Catalase active site + Tetrapyrrole biosynthesis, 5-aminolevulinic acid synthase + Methionine biosynthesis MetW + Transcription termination factor NusA + Domain of unknown function DUF559 + Molybdopterin oxidoreductase, 4Fe-4S domain + Vitamin K-dependent gamma-carboxylase + Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase-like + Potassium uptake protein TrkA + Asparaginase/glutaminase-like + Ubiquinone biosynthesis protein Coq7 + D-Tyr tRNAtyr deacylase-like domain + RNase L inhibitor RLI, possible metal-binding domain + Photosystem II cytochrome b559, N-terminal + U1-C, C2H2-type zinc finger + ABC transport permease subunit MlaE, Proteobacteria + Uncharacterised protein family UPF0592 + Protein of unknown function DUF463, YcjX-like protein + Nrap protein, domain 4 + Deoxynucleoside kinase domain + Sodium/sulphate symporter, conserved site + Thymidylate synthase, active site + NAD(P)H-quinone oxidoreductase, subunit N/subunit 2 + Legume-like lectin + CcmE/CycJ protein + Uncharacterised protein family UPF0012, conserved site + Foie gras liver health family 1 + LPS export ABC transporter permease LptG + N-carbamoylputrescine amidase + Cytochrome c oxidase, subunit II + p-Aminobenzoyl-glutamate transport protein AbgT + Poly(A) polymerase, central domain + Organic solvent tolerance protein, C-terminal + D-3-phosphoglycerate dehydrogenase + TH1 protein + Malate:quinone-oxidoreductase + Pilus formation protein, N-terminal + Alpha-N-acetylglucosaminidase, tim-barrel domain + Tryptophan synthase, alpha chain + Protein of unknown function DUF92, TMEM19 + DNA polymerase III epsilon subunit, exonuclease domain + Predicted integral membrane protein DUF2189 + UvrABC system, subunit C + Isocitrate dehydrogenase NADP-dependent + Conserved hypothetical protein CHP00275, flavoprotein HI0933-like + Calcium/proton exchanger CAX + Protein of unknown function DUF3578 + Clathrin, heavy chain, linker + DDHD domain + THO complex, subunit 5 + Peptidase M76, ATP23 + Conserved hypothetical protein CHP02096 + Protein of unknown function DUF3011 + Domain of unknown function DUF4130 + Organic hydroperoxide resistance protein famiy + LPS-assembly lipoprotein LptE + P-type ATPase, subfamily IV + Acyl-CoA thioester hydrolase YbgC/YbaW family + C-terminal associated domain of TOPRIM + GTP binding protein, second domain + AMP-activated protein kinase, glycogen-binding domain + Polyribonucleotide 5'-hydroxyl-kinase Clp1, P-loop domain + Signal transduction histidine kinase, internal region + Domain of unknown function DUF1126 + Holliday junction DNA helicase ruvB, N-terminal + DNA helicase, Holliday junction RuvB type, C-terminal + Aromatic amino acid hydroxylase, C-terminal + Flagellar basal body rod protein, conserved site + F-actin capping protein, beta subunit, conserved site + Vesicle tethering protein Uso1/P115-like , head domain + Domain of unknown function DUF35, rubredoxin-like zinc ribbon domain, N-terminal + RadC-like JAB domain + UDP-N-acetylglucosamine 2-epimerase WecB-like + Cellulose/chitin-binding protein, N-terminal + Glycoside hydrolase, family 3, active site + Protocatechuate 3,4-dioxygenase, beta subunit + RNA polymerase-binding transcription factor DksA + Phosphopantetheine-protein transferase domain + Pyridoxal phosphate (active vitamin B6) biosynthesis PdxJ + Outer membrane lipoprotein carrier protein LolA-like + Apolipoprotein N-acyltransferase + Acylphosphatase-like domain + Dihydrofolate reductase domain + NADH:ubiquinone oxidoreductase chain 4, N-terminal + Ancestral coatomer element 1, Sec16/Sec31 + Mg chelatase-related protein, C-terminal domain + Deoxyuridine triphosphate nucleotidohydrolase + Ribonucleotide reductase regulator NrdR-like + Eukaryotic porin/Tom40 + DHAP synthase, class 1 + Blood group Rhesus C/E/D polypeptide + Photosystem II cytochrome b559, conserved site + Aspartyl/Glutamyl-tRNA(Gln) amidotransferase, subunit B/E, catalytic + Vacuolar protein sorting-associated protein 62 + Ribosomal protein S8e/ribosomal biogenesis NSA2 + ATP-dependent DNA ligase, PP_1105 family + FIST, C-domain + Dense granule Gra7 protein + Protein of unknown function DUF227 + Chalcone/stilbene synthase, N-terminal + Acetyl-CoA carboxylase, alpha subunit + 30S ribosomal protein + Haemerythrin-like + Peptidase S33 tripeptidyl aminopeptidase-like, C-terminal + Domain of unknown function DUF4483 + Archaeophage PsiM2, terminase large subunit + Proteasome component Ecm29 + Protein of unknown function DUF583 + Helicase/SANT-associated domain + Cytidylate kinase domain + Mon2, dimerisation and cyclophilin-binding domain + Thioredoxin reductase + Chromosome segregation/condensation protein ScpB + Translation initiation factor IF-1 + ROSMUCR transcriptional regulator + RHD3/Sey1 + Phosphatidylserine decarboxylase, archaeal-type + Protein LOW PSII ACCUMULATION 1-like + Zinc finger, DPH-type + Transport and Golgi organisation protein 2 + DNA recombination and repair protein RecA + Large-conductance mechanosensitive channel, conserved site + Ribosomal protein L32e + Glycoside hydrolase, family 29 + Photosystem antenna protein-like + Outer membrane protein assembly factor BamD + DNA ligase, OB-like domain + Phosphate/phosphite/phosphonate ABC transporter, periplasmic binding protein + Torus domain + Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain + GCR1-cAMP receptor + Protein C10 + Ceramide glucosyltransferase + Alanine dehydrogenase + DNA translocase FtsK, 4TM region + Mannose-6-phosphate isomerase + Ketol-acid reductoisomerase + Isopentenyl-diphosphate delta-isomerase, type 1 + Uncharacterised protein family UPF0193 + Phosphocarrier protein HPr-like + Protein of unknown function DUF1217 + Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain + Coatomer beta subunit, C-terminal + TB2/DP1/HVA22-related protein + Oxidoreductase, molybdopterin binding site + Hydroxymethylglutaryl-coenzyme A synthase C-terminal domain + Putative sensory transduction regulator YbjN + S-adenosylmethionine decarboxylase, core + Proline-tRNA ligase, class II, C-terminal + Nitrogen regulatory protein PII, conserved site + Nuclear transcription factor Y subunit A + Photosystem I PsaA/PsaB + Photosynthetic reaction centre, L/M + Haem exporter protein D (CcmD) + Peptidase U32 + Protein of unknown function DUF1810 + Ion channel regulatory protein, UNC-93 + Protein of unknown function DUF901 + Tetracycline transcriptional regulator, TetR-related, C-terminal + Alanine racemase, C-terminal + Lanthionine synthetase C-like + Rad4/PNGase transglutaminase-like fold + Formin, FH3 domain + Protein prenyltransferase, alpha subunit + MATH/TRAF domain + Ubiquitin-activating enzyme E1, FCCH domain + Leucine zipper transcription factor-like protein 1 + UDP-N-acetylmuramate--L-alanine ligase + Endonuclease III + UDP-N-acetylglucosamine 1-carboxyvinyltransferase + Ribosomal protein L26/L24, eukaryotic/archaeal + Clp protease, ATP-binding subunit ClpX + Monothiol glutaredoxin-related + Mg chelatase-related protein + Photosystem II PsbO, manganese-stabilising + DNA polymerase III, beta chain, central + DNA polymerase III, beta chain, N-terminal + DNA polymerase III, beta chain, C-terminal + 30S ribosomal protein S17 + Translation initiation factor IF2/IF5, N-terminal + NLE + RecG, wedge domain + Zinc finger, ClpX C4-type + 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase, type 1 + Flagella basal body P-ring formation protein FlgA, C-terminal + Ribonuclease toxin, BrnT, of type II toxin-antitoxin system + Domain of unknown function DUF448 + Peptidyl-arginine deiminase, Porphyromonas-type + Methylmalonate-semialdehyde dehydrogenase + Cytochrome c-type biogenesis protein CcmB + RNA polymerase Rpb2, domain 4 + RNA polymerase Rpb2, domain 5 + 6-phosphogluconate dehydrogenase, C-terminal + DNA polymerase V + Flp pilus assembly protein RcpC/CpaB domain + Domain of unknown function DUF4704 + DNA repair protein MmcB-like + MRG domain + Ribonuclease CAF1 + Drug resistance transporter Bcr/CmlA subfamily + Formyltetrahydrofolate deformylase + RelA/SpoT family + Lon protease, bacterial/eukaryotic-type + NAD-dependent DNA ligase, conserved site + Protein of unknown function DUF3445 + DNA replication factor RFC1, C-terminal + UDP-galactopyranose mutase, C-terminal + DDE domain + Replication protein A, OB domain + Carboxyltransferase domain, subdomain A and B + Large ribosomal RNA subunit accumulation protein YceD + Endolytic murein transglycosylase + Polysaccharide biosynthesis protein, C-terminal domain + L-lactate/malate dehydrogenase + Copper homeostasis CutC domain + Trafficking protein particle complex subunit 2 + Phosphodiesterase MJ0936/Vps29 + Glycosyl hydrolase family 36, N-terminal + Glycosyl hydrolase family 36, C-terminal + Protein of unknown function DUF1009 + Yjdj-type Gcn5-related N-acetyltransferase + Katanin p80 subunit, C-terminal + DNA topoisomerase I, bacterial-type + DNA topoisomerase IV, subunit B, Gram-negative + Tumour necrosis factor-like domain + Riboflavin kinase, bacterial + Ubiquitinol-cytochrome C reductase, Fe-S subunit, TAT signal + SecE subunit of protein translocation complex + Succinate--CoA synthetase, beta subunit + Phosphoribosylglycinamide formyltransferase + DNA helicase, Holliday junction RuvB type + UvrABC system subunit A + rRNA small subunit methyltransferase I + Beta-lactamase, class-A active site + XPA C- terminal + GxxExxY protein + Integral membrane protein YjbE + Protein of unknown function DUF2892 + Coiled-coil domain-containing protein 22 + Nuclear pore localisation protein Npl4, ubiquitin-like domain + Complement Clr-like EGF domain + Intramolecular chaperone auto-processing domain + Transposase TnpC, homeodomain + Double Cache domain 1 + Protein of unknown function DUF454 + LexA-binding, inner membrane-associated putative hydrolase + Transcription elongation factor GreA + Glutathione synthase domain + Phospho-N-acetylmuramoyl-pentapeptide transferase + DNA-directed DNA polymerase, family B + Urease, gamma/gamma-beta subunit + Succinate dehydrogenase, flavoprotein subunit + Acetoacetyl-CoA reductase + Ribosomal protein S3, conserved site + Transketolase, bacterial-like + RNA 3'-terminal phosphate cyclase domain + Nuclear pore localisation protein NPL4, C-terminal + Rhodanase, C-terminal + Membrane bound O-acyl transferase, MBOAT + Protein of unknown function DUF819 + Domain of unknown function DUF815 + DEAD/H associated + Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site + Urease active site + Ketopantoate reductase ApbA/PanE + DNA-directed RNA polymerase, omega subunit + Phage shock protein, PspC, N-terminal + Aconitase X swivel domain, putative + Cholinesterase + L-asparaginase II + Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase + Dihydroorotate dehydrogenase, class 2 + GH3 family + Reduced folate carrier + Ribosome recycling factor + Urease accessory protein UreD + Single-stranded DNA-binding protein + UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase + Domain of unknown function DUF4062 + Myristoyl-CoA:protein N-myristoyltransferase, N-terminal + RNA methyltransferase TrmH family + EGF-like calcium-binding, conserved site + Acetolactate synthase, large subunit, biosynthetic + Conserved hypothetical protein CHP02300, FYDLN acid + Pyridoxine kinase + Potassium-transporting ATPase A chain + Cofactor assembly of complex C subunit B, CCB2/CCB4 + Pseudouridine-5'-phosphate glycosidase + Spo11/DNA topoisomerase VI, subunit A, N-terminal + Invasion protein B + MlaA lipoprotein + Peptidase family S66 + Meiosis-expressed gene 1 protein + UV excision repair protein Rad23 + Holliday junction DNA helicase RuvA, C-terminal + 4-hydroxybenzoate polyprenyltransferase + Histidinol-phosphate phosphatase, putative, inositol monophosphatase + Phosphoribosylformylglycinamidine synthase subunit PurS + Polysaccharide chain length determinant N-terminal domain + Potassium transporter + Ribosomal protein L22/L17, conserved site + Alpha tubulin + Transcription factor, MADS-box + Glycosyl transferase, ALG6/ALG8 + 14-3-3 protein, conserved site + DNA recombination and repair protein RecA, C-terminal + Ornithine cyclodeaminase, N-terminal + DNA helicase, DnaB type + Cytoplasmic FMR1-interacting + NUC153 + tRNA-specific adenosine deaminase + Glycosyl hydrolase family 32, C-terminal + D-aminoacyl-tRNA deacylase DTD + Multi-copper polyphenol oxidoreductase + Ribosomal protein S3Ae + Alpha-2-macroglobulin + DGQHR-containing domain + PhnA protein, C-terminal + Ribosomal L28e/Mak16 + Rab5-interacting protein family + Primosome PriB/single-strand DNA-binding + Protein of unknown function DUF350 + Sas10/Utp3/C1D + N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine deformylase/Succinyl-diaminopimelate desuccinylase + Cwf19-like protein, C-terminal domain-2 + Gtr1/RagA G protein + Fumarase C, C-terminal + Cwf19-like, C-terminal domain-1 + Oxysterol-binding protein + NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site + Histone chaperone ASF1-like + tRNA (guanine-N1-)-methyltransferase, bacteria + Lysine-tRNA ligase, class II + Proline-tRNA ligase, class IIa + Urease, alpha subunit + Ribosomal protein S12 methylthiotransferase RimO + Di-trans-poly-cis-decaprenylcistransferase-like, conserved site + Host attachment protein + Formate dehydrogenase, transmembrane + Anhydro-N-acetylmuramic acid kinase + Tctex-1 + Mitochondrial pyruvate carrier + RapZ-like family + Phosphatase PHOSPHO-type + Cobalt transporter subunit CbtA, putative + Cobalt transporter subunit CbtB, putative + Histidinol dehydrogenase, conserved site + F-actin-capping protein subunit beta + Glucosidase II beta subunit-like + Activator of Hsp90 ATPase homologue 1-like + Starch synthase, catalytic domain + 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 + Lipoyl synthase + NAD(+) synthetase + ASCH domain + Sulfur carrier protein FdhD + Regulatory protein RecX + HTH-type transcriptional regulator AraC-type, N-terminal + Condensin complex subunit 1, C-terminal + ABC-2 family transporter protein + Phosphotransferase system, enzyme I-like + Domain of unknown function DUF2382 + Clathrin adaptor, mu subunit, conserved site + Peptidase S9, serine active site + Glycoside hydrolase family 15/Phosphorylase b kinase regulatory chain family + Glyoxalase-like domain + SIMIBI class G3E GTPase, ArgK/MeaB + Hydroxymethylglutaryl-CoA reductase, N-terminal + Domain of unknown function DUF4201 + Polyphosphate kinase 2, PA0141 + CDK5 regulatory subunit-associated protein 3 + Protein of unknown function DUF3089 + Integral membrane protein EMC3/TMCO1-like + 4-hydroxy-2-oxovalerate aldolase + Alanine racemase, pyridoxal-phosphate attachment site + Formate-tetrahydrofolate ligase, FTHFS, conserved site + Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase + Putative Flp pilus-assembly TadG-like, N-terminal + Transcription factor zinc-finger + FKBP12-rapamycin binding domain + Condensin complex subunit 2/barren + Dihydroxy-acid dehydratase + Biotin--acetyl-CoA-carboxylase ligase + ATPase MipZ + Inner membrane protein YedI + Sulphotransferase Stf0, domain + Pyridoxamine 5'-phosphate oxidase, Alr4036 family, FMN-binding domain + PhnB-like + Vitamin K epoxide reductase + DNA recombination protein RecR + Flagellar M-ring C-terminal + RNA cap guanine-N2 methyltransferase + GPI mannosyltransferase 2 + Small-subunit processome, Utp21 + Protein of unknown function DUF4419 + BCS1, N-terminal + Glutamate--cysteine ligase, GCS2 + Thioredoxin/glutathione reductase selenoprotein + Glycerol-3-phosphate acyltransferase, PlsY + Rhodopsin, retinal binding site + Inositol oxygenase + LexA repressor, DNA-binding domain + Peptidase S24, LexA-like + Pyridoxine 5'-phosphate oxidase, dimerisation, C-terminal + Ragulator complex protein LAMTOR3 + tRNA synthetase, B5-domain + eRF1 domain 3 + eRF1 domain 2 + eRF1 domain 1/Pelota-like + Adenylosuccinate lyase + Homoserine/serine acetyltransferase MetX-like + MetA family + Anion-transporting ATPase-like domain + Domain of unknown function DUF4172 + Protein of unknown function DUF3703 + Glycosyl hydrolase family 32, N-terminal + Ubiquinol-cytochrome c chaperone/UPF0174 + SRP-independent targeting protein 3 + Photosystem I PsaE, reaction centre subunit IV + Cytosolic fatty-acid binding + Peptidase S49, serine-peptidase prokaryotes + Survival protein SurE-like phosphatase/nucleotidase + Protein-L-isoaspartate(D-aspartate) O-methyltransferase + Succinyl-CoA synthetase, beta subunit, conserved site + Serine acetyltransferase, N-terminal + Conserved oligomeric Golgi complex subunit 6 + tRNA intron endonuclease, catalytic domain-like + Lipoyl synthase, N-terminal + UDP-N-acetylglucosamine 2-epimerase domain + TMEM144 + Bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase + Ribonuclease H1, N-terminal + Replication protein A, C-terminal + DWNN domain + SMc04008-like domain + Protein of unknown function DUF1118 + Alpha-L-rhamnosidase, concanavalin-like domain + Ubiquitin-fold modifier 1 + TRAP transporter solute receptor, DctP family + Ferredoxin, C-terminal + Peptidase M1, alanyl aminopeptidase + Diphthamide synthesis DPH1/DPH2 + Initiation factor 2 associated domain, bacterial + RNA ligase T4 Rnl1, N-terminal + Homoserine kinase + Beta-lactamase, class-A + Domain of unknown function DUF1793 + CWC16 protein + tRNA pseudouridine synthase II, TruB + AsmA + Electron transfer flavoprotein subunit alpha, conserved site + Tryptophan synthase, alpha chain, active site + Pyruvate kinase, active site + L-asparaginase, N-terminal + Protein-only RNase P, C-terminal + Murein tetrapeptide carboxypeptidase, N-terminal domain + Superoxide dismutase, Nickel-type + Tex-like protein, N-terminal + Protein of unknown function DUF1997 + DEAD/DEAH-box helicase, putative + Na+/H+ antiporter MnhB subunit-related protein + Desulfoferrodoxin, ferrous iron-binding domain + Ku70/Ku80, N-terminal alpha/beta + PhoPQ-activated pathogenicity-related protein, PqaA type + Prokaryotic glutathione synthetase, N-terminal + FAM227 Protein + Purine-cytosine permease + GUCT + Rrp44-like cold shock domain + Exosome complex exonuclease RRP44, S1 domain + NADH:ubiquinone/plastoquinone oxidoreductase, chain 3 + VIT domain + Hydroxymethylglutaryl-CoA synthase, eukaryotic + Succinate dehydrogenase, cytochrome b556 subunit + Guanine deaminase + Molybdopterin oxidoreductase, prokaryotic, conserved site + Arsenate reductase + CobB/CobQ-like glutamine amidotransferase + Peptidase C26 + RNA polymerase Rpb2, OB-fold + Nicotinate-nucleotide pyrophosphorylase + 4-diphosphocytidyl-2C-methyl-D-erythritol kinase + Protein of unknown function DUF1285, beta-roll domain + GOLD domain + Domain of unknown function DUF262 + Yippee/Mis18/Cereblon + SLIDE domain + Translation elongation factor SelB, winged helix, type 2 + WYL domain + Vacuolar protein sorting protein 26 related + Microcystin LR degradation protein MlrC, N-terminal + Uncharacterised hydrolase TatD-type + Luciferase family oxidoreductase, group 1 + NOP5, N-terminal + Actin, conserved site + DhaL domain + Alcohol dehydrogenase, iron-type + Large-conductance mechanosensitive channel + Citron homology (CNH) domain + DNA recombination RmuC + Alkyl sulfatase dimerisation domain + Alkyl sulfatase, C-terminal + Phosphopantetheine adenylyltransferase + Polyphosphate kinase middle domain + Protein of unknown function DUF192 + Extensin-like, C-terminal + Profilin + Bacteriophage/plasmid primase, P4, C-terminal + Aminopeptidase P, N-terminal + Growth factor receptor domain 4 + Phytoene desaturase + Carotenoid/retinoid oxidoreductase + Di-haem cytochrome c peroxidase + ABC-type transport auxiliary lipoprotein component + Rhamnose/fucose mutarotase + DNA gyrase inhibitor YacG + Protein of unknown function DUF72 + Intra-flagellar transport protein 57 + DNA repair metallo-beta-lactamase + DNA polymerase III, gamma subunit, domain III + AMP nucleoside phosphorylase, N-terminal + Phosphoinositide 3-kinase, accessory (PIK) domain + Ferroporti-1 + YhhN-like + Vps54-likeVacuolar protein sorting-associated protein 54, C-terminal + Dihydroorotase homodimeric type + Chalcone isomerase, 3-layer sandwich + Nitrilase/cyanide hydratase, conserved site + Limonene-1,2-epoxide hydrolase + Lycopene cyclase, beta/epsilon + Nucleolar protein 14 + YTH domain + Epoxyqueuosine reductase QueG + Lipoxygenase, C-terminal + TPX2 central domain + Heat-inducible transcription repressor HrcA + Penicillin amidase type, domain1 + Lysozyme domain + Haem-degrading + Signal-recognition particle receptor FtsY + RNA methyltransferase, RsmD + Capsule synthesis protein, CapA + Carbonic anhydrase, cadmium-binding + HNH nuclease + Formate dehydrogenase, delta subunit + PRMT5 arginine-N-methyltransferase + DREV methyltransferase + ATPase, OSCP/delta subunit, conserved site + SUF system FeS cluster assembly associated + Tol-Pal system, TolQ + Glutathione synthetase, prokaryotic + Protein DJ-1 + Peptidoglycan-associated lipoprotein + Alpha/beta-hydrolase, N-terminal domain + Post-segregation antitoxin CcdA + Ig-like SoxY domain + Primosomal protein N' + PdxA family + O-acyltransferase, WSD1, N-terminal + Bud13 + Phosphotransferase system, mannose-type IIA component + Ran binding domain + EGF-type aspartate/asparagine hydroxylation site + Cof family + Homeobox KN domain + Male sterility, NAD-binding + Ferric reductase, NAD binding domain + Putative rhamnosyl transferase + Vps52 + Nuclear pore protein 84/107 + UDP-N-acetylenolpyruvoylglucosamine reductase + Mo25-like + Protein of unknown function DUF1761 + Uncharacterised protein family C20orf85 + Urate oxidase N-terminal + Lipid droplet-associated hydrolase + Lipoprotein-releasing system transmembrane protein LolC/E + Down-regulated-in-metastasis protein + Protein phosphatase 2A, regulatory B subunit, B56 + Glycosyl transferase, family 43 + Sjoegren syndrome/scleroderma autoantigen 1 + Protein of unknown function DUF1178 + G-protein, beta subunit + DNA-directed RNA polymerase, N-terminal + Methylated-DNA-[protein]-cysteine S-methyltransferase, active site + Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase + Clathrin, heavy chain/VPS, 7-fold repeat + Flagellar motor protein MotA, conserved site + Prephenate dehydrogenase + Catalase-peroxidase haem + DNA-directed RNA polymerase beta subunit, bacterial-type + Glycoside hydrolase, family 25 + Ribonuclease E inhibitor RraA/RraA-like protein + Leucine-rich glioma-inactivated , EPTP repeat + Twin-arginine translocation protein TatB + Uracil-DNA glycosylase family 4 + C-type lysozyme inhibitor + Protein of unknown function DUF2125 + Heat shock protein Hsp33, C-terminal + Chlorophyllase + DNA metabolism protein, putative + Trafficking protein particle complex subunit + DNA repair protein Rad52/59/22 + Glutaredoxin, GrxC + Ubiquitin-activating enzyme E1 + Cyclic nucleotide-regulated ion channel, N-terminal domain + Cardiolipin synthase N-terminal + Ribosomal protein L29, conserved site + Erythromycin esterase + RNA-binding protein Hfq + Uncharacterised conserved protein UCP032025 + Histidine-specific methyltransferase, SAM-dependent + Alpha-L-arabinofuranosidase B, catalytic + Tetrahydrodipicolinate N-succinyltransferase, transferase hexapeptide repeat family + Protein-export membrane protein SecF, bacterial + dTDP-4-dehydrorhamnose reductase family + Phenylalanine-tRNA ligase, class IIc, beta subunit + Selenophosphate synthetase + Transcription activator GCR1-like domain + Heparinase II/III-like + Protein of unknown function DUF3987) + Growth arrest-specific protein 8 + FAD synthetase + Transcription antitermination protein, NusG, bacteria, conserved site + 7-carboxy-7-deazaguanine synthase, Cx14CxxC-type + Alpha-N-acetylglucosaminidase, N-terminal + NSF attachment protein + EGF-like domain + VCBS repeat + Protein of unknown function DUF501 + Nuclear transport factor 2 + Crossover junction endodeoxyribonuclease RuvC, magnesium-binding site + Trigger factor + Protein of unknown function DUF2071 + Protein of unknown function DUF3553 + Urease alpha-subunit, N-terminal domain + Isopropylmalate dehydrogenase + Methylmalonyl-CoA epimerase + Gcn5-related N-acetyltransferase (GNAT) domain, ATAT-type + PSP, proline-rich + Clan AA aspartic peptidase, C-terminal + 16S rRNA processing protein RimM + DNA-binding protein Dps, conserved site + Tetrahydrodipicolinate-N-succinyltransferase, chain A, domain 1 + Rab GDI protein + Transposase IS66, Orf2 + Uncharacterised conserved protein UCP016719 + Integration host factor, alpha subunit + Delta-1-pyrroline-5-carboxylate dehydrogenase 3 + HEAT repeat associated with sister chromatid cohesion protein + Beta-lactamase hydrolase-like + Modification methylase HemK + Lsm14-like, N-terminal + Aromatic amino acid lyase + NECAP, PHear domain + Protein of unknown function DUF4079 + Alpha-N-acetylglucosaminidase, C-terminal + Frataxin/CyaY + Optic atrophy 3-like + HopJ type III effector protein + Aromatic-L-amino-acid decarboxylase + Glycine cleavage system T protein + Hyaluronan-mediated motility receptor, C-terminal + Protein of unknown function DUF1467 + Replication factor A, C-terminal + Polynucleotide kinase 3 phosphatase + Domain of unknown function DUF4964 + Co-chaperone DjlA, N-terminal + NTP pyrophosphohydrolase MazG + V-ATPase proteolipid subunit C, eukaryotic + Glutamate--cysteine ligase, plant-type + Quinone oxidoreductase PIG3 + Uncharacterised protein family UPF0758, conserved site + Fructose-1,6-bisphosphatase, active site + Urease, beta subunit + Proteasome/cyclosome repeat + Metallophosphoesterase, YmdB-like + Toxin HigB-like + Cofactor assembly of complex C subunit B, CCB1 + Zinc-finger, NAD-dependent DNA ligase C4-type + mRNA capping enzyme, catalytic domain + Domain of unknown function DUF4136 + RecQ mediated genome instability protein, N-terminal + Glutaredoxin 2, C-terminal + LytTR DNA-binding domain + Protein of unknown function DUF3572 + HAD-superfamily hydrolase,subfamily IIIA + BCCT transporter family + Flagellar M-ring protein FliF + Delta-aminolevulinic acid dehydratase, active site + Protein of unknown function DUF3576 + Glutathione synthase, N-terminal, eukaryotic + Chromate transporter, long chain + Domain of unknown function DUF1115 + Dullard phosphatase domain, eukaryotic + Steroid delta5-4-isomerase + CDC50/LEM3 family + Pyridoxamine 5'-phosphate oxidase, conserved site + 4-hydroxyphenylpyruvate dioxygenase + Lipid/polyisoprenoid-binding, YceI-like + Headcase protein + Pyrrolo-quinoline quinone-like domain + Urease nickel binding site + Calcium release-activated calcium channel protein + Translation initiation factor IF2/IF5 + Flagellar P-ring protein + Cellulose-binding domain, fungal + Flagellar L-ring protein + Lumazine synthase + Protocatechuate 3,4-dioxygenase beta subunit, N-terminal + Enhancer of rudimentary + Citrate synthase, type I + Flagellar C1a complex subunit C1a-32 + Translation initiation factor, beta propellor-like domain + G protein alpha subunit, helical insertion + Branched-chain amino acid aminotransferase I + Threonine dehydratase, biosynthetic + Branched-chain amino acid aminotransferase II + Mut7-C RNAse domain + Glycoside hydrolase, family 8 + Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA + Major capsid protein GpE + Protein of unknown function DUF2171 + 6-phosphogluconate dehydratase + Signal recognition particle protein Ffh + Acetolactate synthase, small subunit + ABC transporter, ATP-binding protein, ChvD + Coenzyme A transferase binding site + Ataxin-10 domain + Protein of unknown function DUF3035 + Domain of unknown function DUF4167 + Domain of unknown function DUF5110 + Ornithine cyclodeaminase/mu-crystallin + Protein of unknown function DUF721/UPF0232 + Dihydrodipicolinate reductase + PilZ domain + DNA-directed DNA polymerase, family A, conserved site + Translation elongation factor, IF5A, hypusine site + Light-dependent protochlorophyllide reductase + DmpG-like communication + Glyoxalase I, conserved site + Peptide chain release factor 1 + Replication factor A protein 1 + Splicing factor, RBM39-like + Zinc finger, CCCH-type, TRM13 + BLUF domain + Copper centre Cu(A) + Wax synthase domain + DoxX family + Nucleotide exchange factor Fes1 + FO synthase, subunit 2 + Udp N-acetylglucosamine O-acyltransferase, C-terminal + Photosystem I PsaA/PsaB, conserved site + DNA recombination/repair protein RecA, conserved site + 3-phosphoshikimate 1-carboxyvinyltransferase + Cytidine deaminase, homotetrameric + dNTP triphosphohydrolase + UDP-N-acetylmuramoylalanine-D-glutamate ligase + Inositol-pentakisphosphate 2-kinase + ATPase, AAA-3 + Domain of unknown function DUF625 + Nucleoside diphosphate kinase, active site + Membrane insertase YidC, N-terminal + Phosphotransferase system, enzyme I N-terminal + Translation elongation factor IF5A + EGF-like calcium-binding domain + Domain of unknown function DUF3385, target of rapamycin protein + Translocation and assembly module TamB + DNA polymerase III chi subunit, HolC + DNA primase, phage/plasmid + Alpha-L-rhamnosidase C-terminal domain + MltA-interacting MipA + Succinate dehydrogenase/fumarate reductase, flavoprotein subunit + PTS EIIA type-2 domain + NatC N(alpha)-terminal acetyltransferase, Mak10 subunit + Protein of unknown function DUF4864 + Transcription factor TFIIB + Domain of unknown function DUF4456 + Protein of unknown function DUF4486 + Glycoside hydrolase, family 65, central catalytic + Glycoside hydrolase, family 65, N-terminal + U2 auxiliary factor small subunit + TATA box binding protein associated factor (TAF) + Basic leucine zipper domain, Maf-type + Vacuolar fusion protein Mon1 + Phosphoenolpyruvate carboxylase, Lys active site + Protein of unknown function DUF829, TMEM53 + Hypothetical PA1492 domain + Anaphase-promoting complex subunit 4 long domain + Ribosomal protein L15e core domain + SKP1 component, POZ domain + SKP1 component, dimerisation + Siroheme synthase, central domain + E3 ubiquitin ligase, UBR4 + F-type ATP synthase subunit B-like, membrane domain + Arsenite-resistance protein 2 + Uncharacterised membrane protein YitT + Cyclodeaminase/cyclohydrolase + RNA polymerase sigma factor 54, core-binding + Carbohydrate-selective porin OprB + DNA-directed RNA polymerase, M/15kDa subunit + IMS import disulfide relay-system, CHCH-CHCH-like Cx9C + Carbamoyltransferase, C-terminal + Condensin-2 complex subunit H2, C-terminal + TRAPP II complex, Trs120 + Small-subunit processome, Utp13 + RNA polymerase II-associated protein 1, N-terminal + TATA-binding protein interacting (TIP20) + E2 binding + Photosystem I PsaB + Glycoside hydrolase, family 43 + Photosystem II cytochrome b559, beta subunit + 3(2),5 -bisphosphate nucleotidase, bacterial + Photosystem I PsaA + Protein kinase C-like, phorbol ester/diacylglycerol-binding domain + GWT1 + Protein of unknown function DUF1077, TMEM85 + L-seryl-tRNA selenium transferase-like + Lipopolysaccharide assembly protein A domain + WD repeat protein mio, zinc-ribbon like domain + Alginate lyase domain + Intron-binding protein aquarius, N-terminal + DNA mismatch repair protein MutS + Archease domain + PTHB1, C-terminal domain + Nicastrin + SAM-dependent methyltransferase, NodS-related + Conserved oligomeric Golgi complex subunit 7 + Peroxisome biogenesis factor 1, N-terminal, psi beta-barrel fold + FAM192A/Fyv6, N-terminal + Mesoderm development candidate 2 + Organic solute carrier protein 1 + GTP-binding protein OBG, C-terminal + Cell division topological specificity factor MinE + tRNA-dihydrouridine synthase, TIM-barrel, NifR3 + Beta propeller domain-containing family + AATF leucine zipper-containing domain + ABC transporter, ATPase, putative + Transcription elognation factor Eaf, N-terminal + Gene transfer agent, major tail protein + Domain of unknown function DUF3495 + RecB family nuclease, TM0106, putative + Malate dehydrogenase, type 1 + Recombination protein RecR, conserved site + NADPH-dependent 7-cyano-7-deazaguanine reductase QueF + Uridylate kinase, bacteria + Apoptosis-antagonizing transcription factor, C-terminal + CDP-alcohol phosphatidyltransferase, C-terminal + DNA topoisomerase I, domain 1 + Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain + Rit1, N-terminal domain + Lung seven transmembrane receptor-like + Zinc finger, TFIIB-type + Uncharacterised protein family Ycf36 + DNA ligase D, 3'-phosphoesterase domain + Protein phosphatase 2A regulatory subunit PR55 + WW domain binding protein 11 + S-adenosylmethionine decarboxylase, conserved site + Putative threonine/serine exporter + Malonyl CoA-acyl carrier protein transacylase, FabD-type + 3D domain + Pescadillo + ALG11 mannosyltransferase, N-terminal + Phosphoribosylformylglycinamidine subunit PurL + Amino acid adenylation domain + HAD-superfamily hydrolase, subfamily IB, SerB1-like + Phosphoribosylformylglycinamidine synthase + xxxLxxG heptad repeat + Acetophenone carboxylase beta subunit/Acetone carboxylase gamma subunit + SseB protein N-terminal domain + Type IV conjugative transfer system, protein TraL + Signal peptidase complex subunit 3 + Abnormal spindle-like microcephaly-associated protein, ASH domain + Putative TPR-like repeat + Domain of unknown function DUF775 + Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 + Photosystem II PsbY + Regulatory factor, effector binding domain + Fibrogen-binding domain 1 + Protein of unknown function DUF408 + GSKIP domain + WTAP/Mum2 family + TAP42-like protein + Zinc finger, DNA-directed DNA polymerase, family B, alpha + Glutamine synthetase type I + Translationally controlled tumour protein + tRNA pseudouridine synthase B family + ATPase, V0 complex, subunit e1/e2 + Haem oxygenase + Retinoblastoma-associated protein, A-box + Domain of unknown function DUF3456 + PAM68-like + WASH1, WAHD domain + XRN-Two Binding Domain, XTBD + C-type cytochrome, methanol metabolism-related + Fyv7/TAP26 + DNA glycosylase/AP lyase, zinc finger domain, DNA-binding site + Surface presentation of antigen (SpoA) + Peptidase M2, peptidyl-dipeptidase A + Retrieval of early ER protein Rer1 + Protein hinderin + Cytochrome b6-f complex Fe-S subunit + Nucleoporin, Nup133/Nup155-like, N-terminal + Alpha/beta hydrolase fold-5 + Uncharacterised protein family HutD/Ves + Transcription regulator HTH, Crp-type, conserved site + Squalene cyclase + DNA-directed RNA polymerase, phage-type + Protein of unknown function DUF1058 + Proteasome assembly chaperone 4 + Coatomer subunit gamma, C-terminal + Cilia- and flagella-associated protein 61, N-terminal domain + Ribosomal protein S10, eukaryotic/archaeal + ATPase, V1 complex, subunit A + ATPase, V1 complex, subunit B + Ribosomal protein L22/L17, eukaryotic/archaeal + Phosphonate metabolism protein PhnI + Autophagy-related protein 3, C-terminal + Conserved oligomeric Golgi complex subunit 5 + WIBG family + Linker histone H1/H5, domain H15 + Protein of unknown function DUF4089 + Glycosyl hydrolase 36, catalytic domain + Ribosomal protein S8e + XPG/Rad2 endonuclease, eukaryotes + Spermidine/spermine synthases + Proliferating cell nuclear antigen, PCNA, C-terminal + Proliferating cell nuclear antigen, PCNA, N-terminal + Chemotaxis receptor methyltransferase CheR, N-terminal + Protein of unknown function DUF3253 + Putative ABC transporter periplasmic binding protein PhnD-like + Sulfite dehydrogenase SoxC + Quinoprotein dehydrogenase-associated SoxYZ-like carrier + Nucleolar 27S pre-rRNA processing, Urb2/Npa2, C-terminal + Protein of unknown function DUF2442 + RNA polymerase sigma factor 54 + FeoB-type guanine nucleotide-binding (G) domain + Chromosomal replication control, initiator DnaA + Ribosomal RNA-processing protein 7 + Condensin complex subunit 1, N-terminal + Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family + Metaxin, glutathione S-transferase domain + Protein of unknown function DUF962 + Domain of unknown function DUF1254 + RNA methyltransferase bin3, C-terminal + Nucleolar GTP-binding protein 1, Rossman-fold domain + Anti-sigma-28 factor, FlgM + Elongation factor P hydroxylase + SinI-like, DNA-binding domain + Protein phosphatase 4 core regulatory subunit R2 + Ataxin-2, C-terminal + NAD-dependent DNA ligase, active site + Peptidase HybD-like domain + RZZ complex, subunit Zw10 + Pre-mRNA-splicing factor Isy1 + Coenzyme PQQ biosynthesis protein A + Phosphate ABC transporter, substrate-binding protein PstS + Hypoxanthine phosphoribosyl transferase + GC-rich sequence DNA-binding factor domain + Dynein family light intermediate chain + 40S ribosomal protein S4, C-terminal domain + Antitoxin ParD + Phosphoenolpyruvate carboxylase, His active site + ABC transporter, substrate-binding protein, PQQ-dependent alcohol dehydrogenase system + Coenzyme PQQ synthesis D, bacteria + THO complex subunit 7/Mft1 + SRP-independent targeting protein 2/TMEM208 + Pre-mRNA splicing factor component Cdc5p/Cef1 + O-phosphoseryl-tRNA(Sec) selenium transferase + Dihydrofolate reductase conserved site + Asp/Glu racemase, active site 1 + Dynein attachment factor, N-terminal + Protein of unknown function DUF2127 + Ribosomal protein L37e + FANCI solenoid 4 domain + Glycosyl transferase family 54 + Opioid growth factor receptor (OGFr) conserved domain + CRISPR-associated protein, Cas5 + TAFII55 protein, conserved region + Uncharacterised protein family UPF0145/C2CD5 + Sortilin, C-terminal + SF3A3 domain + Chromophore lyase CpcT/CpeT + Cofactor of BRCA1 + Domain of unknown function DUF4460 + Ribosomal protein S2, eukaryotic/archaeal + Ribosomal protein S3, eukaryotic/archaeal + Exopolysaccharide synthesis protein + Photosystem I PsaJ, reaction centre subunit IX + Zinc finger, CHCC-type + Phosphoribosylaminoimidazole carboxylase, ATPase subunit + Cytochrome b6/f complex, subunit IV + FAM178 family + Nitrous-oxide reductase + Protein of unknown function DUF2889 + Arginase + Macrophage migration inhibitory factor + Conserved hypothetical protein CHP02391 + Bacterial RecJ exonuclease + Domain of unknown function DUF2241 + Domain of unknown function DUF2236 + Protein of unknown function DUF1853 + Protein of unknown function DUF1850 + Nitrile hydratase beta subunit domain + Stomatin family + Ribosomal protein L40e + Uncharacterised conserved protein UCP014543 + Pre-mRNA cleavage complex subunit Clp1 + Sugar transport protein + Uncharacterised protein family, zinc metallopeptidase putative + Protein of unknown function DUF485 + Protein of unknown function DUF481 + Domain of unknown function DUF418 + Nrap protein domain 1 + Urocanase, Rossmann-like domain + SGS domain + UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase LpxD + Type II secretion system, protein M + Nucleoporin interacting component Nup93/Nic96 + Zinc finger, C2HC5-type + Nitrogen permease regulator 2 + Protein of unknown function DUF4602 + DET1- and DDB1-associated protein 1, N-terminal + Ribosomal protein S21, conserved site + Short chain fatty acid transporter AtoE + Lipocalin, bacterial + DNA replication factor Cdt1, C-terminal + Transthyretin, conserved site + Transthyretin, thyroxine binding site + Recombinase zinc beta ribbon domain + RNA (C5-cytosine) methyltransferase, NOP2 + DNA polymerase III, subunit gamma/ tau, C-terminal + Minichromosome loss protein Mcl1, middle region + Protein of unknown function DUF810 + Protein of unknown function DUF2497 + RNA polymerase, Rpb8 + Gingipain + Periplasmic binding protein/LacI sugar binding domain + RNA polymerase III subunit RPC82-related, helix-turn-helix + ATP:cob(I)alamin adenosyltransferase CobA/CobO/ButR + Actin-related protein 2/3 complex subunit 2 + Histone deacetylase interacting domain + Precorrin-6x reductase + Cobalamin (vitamin B12) biosynthesis CobH/CbiC, precorrin-8X methylmutase + Ciliary BBSome complex subunit 2, C-terminal domain + DNA-directed RNA polymerase III subunit RPC4 + Adenylate cyclase-associated CAP, N-terminal + Creatininase-like domain + Prokaryotic transglycosylase, active site + Las1-like + RNAse P, Rpr2/Rpp21 subunit + Ribosome biogenesis protein, C-terminal + Minor spike protein + 26S proteasome complex ubiquitin receptor, subunit Rpn13 + SH2 domain + Bacterial general secretion pathway protein G-type pilin + FACT complex subunit POB3-like, N-terminal PH domain + Zincin-like metallopeptidase + Domain of unknown function DUF1017 + Coiled-coil domain-containing protein 124 + CASTOR/POLLUX/SYM8 ion channels + Dynein assembly factor 3, C-terminal domain + Quinohemoprotein amine dehydrogenase, gamma subunit maturation protein + Quinohemoprotein amine dehydrogenase, alpha subunit + Protein of unknown function DUF2985 + Prefoldin alpha subunit, archaea-type + TAFII28-like protein + Flagellar motor switch protein FliG, C-terminal + Histamine H3 receptor + GTP cyclohydrolase 1 type 2/Nif3 + Ubiquitin/SUMO-activating enzyme ubiquitin-like domain + Ribosomal protein L29e + Ribosomal protein L37ae + Ribosomal protein L38e + Cystathionine beta-synthase + Peroxide stress protein YaaA + DEAD box helicase DbpA/CsdA, RNA-binding domain + E2F transcription factor, CC-MB domain + 40S ribosomal protein S11, N-terminal + CCR4-NOT transcription complex subunit 1, TTP binding domain + RAWUL domain + Ubiquitin-like modifier-activating enzyme Atg7, N-terminal + CCR4-NOT transcription complex subunit 1, HEAT repeat + Domain of unknown function DUF4010 + Nitrous oxide reductase accessory protein NosL + Chitin-binding, type 1 + Glycoside hydrolase family 10 domain + Zinc finger, ZPR1-type + Domain of unknown function DUF2329 + Allantoicase domain + Cysteinyl-tRNA synthetase, class Ia, DALR + Plectin/S10, N-terminal + Uncharacterised protein family UPF0565 + Tetrapyrrole biosynthesis, glutamate-1-semialdehyde aminotransferase + Peptidase S49, protease IV + 4-aminobutyrate aminotransferase, bacterial + Uncharacterised protein family UPF0324, bacteria + Autophagy-related protein 22-like + Rad21/Rec8-like protein, C-terminal, eukaryotic + Pre-rRNA-processing protein IPI1/Testis-expressed sequence 10 protein + PI31 proteasome regulator, N-terminal + Protein of unknown function DUF2948 + Domain of unknown function DUF2428, death-receptor-like + Telomere length regulation protein, conserved domain + Peptidase S11, D-Ala-D-Ala carboxypeptidase A, C-terminal + 8-oxoguanine DNA glycosylase, N-terminal + GPI inositol-deacylase PGAP1-like + DNA/RNA-binding protein Kin17, conserved domain + Protein of unknown function DUF866, eukaryotic + Domain of unknown function DUF427 + Septum formation inhibitor MinC, C-terminal + Microviridae F protein + Nin one binding (NOB1) Zn-ribbon-like + Cathepsin C exclusion + Protein phosphatase inhibitor + tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 + Squalene cyclase, N-terminal + Squalene cyclase, C-terminal + Cupin domain of unknown function DUF985 + Ribosomal protein L21e, conserved site + Annexin repeat, conserved site + DNA helicase + ResB-like domain + Ribosomal protein L13e, conserved site + 5'-Nucleotidase, conserved site + Secretion protein HlyD, conserved site + Dipeptidylpeptidase IV, N-terminal domain + WxcM-like, C-terminal + Intraflagellar transport protein 20 + Nitrous oxide reductase family maturation protein NosD + Circularly permuted ATP-grasp type 2 + Protein of unknown function DUF3429 + Deoxyguanosinetriphosphate triphosphohydrolase, central domain + Protein FAM135 + 4-hydroxybenzoyl-CoA thioesterase, active site + Protein of unknown function DUF2870 + G10 protein + Doubled CXXCH motif + POPLD + PRO8NT domain + PetM of cytochrome b6/f complex subunit 7 + Sulphur oxidation, SoxY + Ribosomal protein L15e + Checkpoint protein Hus1/Mec3 + LemA + SpoVT-AbrB domain + o-Succinylbenzoate synthase, MenC type 2 + Uncharacterised peroxidase-related + Ras-like guanine nucleotide exchange factor, N-terminal + Flavin-dependent halogenase + Adenine nucleotide translocator 1 + Aliphatic acid kinase, short-chain, conserved site + U6 snRNA phosphodiesterase Usb1 + Association with the SNF1 complex (ASC) domain + Ku, C-terminal + Domain of unknown function DUF4524 + SCL-interrupting locus protein + Symplekin/Pta1, N-terminal + Zinc finger domain-containing protein 24, zinc-binding domain + Protein of unknown function DUF1345 + Spt4/RpoE2 zinc finger + 3-isopropylmalate dehydratase, large subunit + 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase + Isocitrate dehydrogenase NADP-dependent, monomeric + Translation initiation factor 2, gamma subunit, C-terminal + Lytic transglycosylase MltA, domain B + Phosphomannomutase + Ribosomal biogenesis, methyltransferase, EMG1/NEP1 + Protein of unknown function DUF2306, membrane + Uncharacterised protein family Ycf55 + ATP synthase, F0 complex, subunit B/MI25 + Centromere protein Mis12 + FMN reductase, MsuE-like + Transcription factor TFIIE alpha subunit, C-terminal + Chromosome segregation in meiosis protein 3 + Signal recognition particle receptor, beta subunit + Domain of unknown function DUF2012 + Ribosome biogenesis protein Nop16 + BrnA antitoxin of type II toxin-antitoxin system + Low temperature viability protein + TIP41-like protein + Cytochrome b6/f complex, subunit 5 + Thaumatin + Ribosomal protein S21e + Flagellar assembly regulator FliX, class II + Glycoside hydrolase family 9, His active site + Flagellar biosynthesis protein FlhA + DNA polymerase 3, epsilon subunit + Sulphate adenylyltransferase, small subunit + Glycogen/starch/alpha-glucan phosphorylase + Protein of unknown function DUF963 + Cu(I)-responsive transcriptional regulator + RNA polymerase Rpc34 + MOFRL domain + Glycoside hydrolase, family 37, conserved site + Stomatal closure-related actin-binding protein, fused Ig-PH domain + AMP-dependent ligase, C-terminal + RPA-interacting protein, C-terminal domain + Menaquinone biosynthesis protein MenD, middle domain + Domain of unknown function DUF2268 + RNA polymerase Rpb1, domain 6 + U3 small nucleolar RNA-associated protein 15, C-terminal + TfoX, N-terminal + L-seryl-tRNA selenium transferase N-terminal domain + RNA polymerase Rpb1, domain 7 + RNA recognition motif, spliceosomal PrP8 + Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding + Serine dehydratase beta chain + Uncharacterised protein family UPF0114 + ATPase, V1 complex, subunit F + Chromatin target of PRMT1 protein, C-terminal + SoxAX cytochrome complex subunit A + Nucleoporin Nup54, alpha-helical domain + Motility protein B, N-terminal domain + Histone deacetylase complex subunit SAP30, Sin3 binding domain + Mediator complex, subunit Med25, von Willebrand factor type A + Transcription factor TFIIB, cyclin-like domain + Protein of unknown function DUF3054 + TAF6, C-terminal HEAT repeat domain + Protein of unknown function DUF4558 + DNA topoisomerase I, N-terminal + Muconate/chloromuconate cycloisomerase + NfeD-like, C-terminal domain + Aspartate dehydrogenase + 3-dehydroquinate synthase + Ribonuclease H2, subunit C + Signal transduction response regulator, chemotaxis, protein-glutamate methylesterase + RNA polymerase II associated factor Paf1 + Autophagy-related protein 3, N-terminal + SHS2 domain inserted in FtsA + Uncharacterised conserved protein UCP01500 + Ribosomal protein S30 + Pex, N-terminal + JAB domain, prokaryotic + FAM91, C-terminal domain + ATPsynthase alpha/beta subunit, N-terminal extension + Cytochrome c, class II + Cytochrome f + Spermidine/putrescine ABC transporter, ATP-binding subunit + Glycine betaine transport ATP-binding subunit + Ribosomal protein L39e domain + Ribosomal protein L31e domain + Replication protein C + Xanthine phosphoribosyltransferase + Deoxyribonuclease II + Glutamyl-tRNA(Gln) amidotransferase A subunit + Nucleoside-triphosphatase, THEP1 type + ER membrane protein complex subunit 8/9 + Nitrogen permease regulator 3 + Nucleotidyltransferase, predicted + 5-bromo-4-chloroindolyl phosphate hydrolysis protein + B-box-type zinc finger + Nitrogenase component 1, conserved site + Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO + Protein of unknown function DUF2997 + Protein of unknown function DUF2993 + Glutamate 5-kinase, conserved site + Sensitivity To Red Light Reduced-like, SRR1 + Phenol hydroxylase, C-terminal dimerisation domain + Type II secretion system protein G + Ribonuclease H2, subunit B + Pilus biogenesis CpaD-related + Photosystem I PsaF, reaction centre subunit III + FHIPEP conserved site + Domain of unknown function DUF4394 + Domain of unknown function DUF4396 + FMN-binding + Phosphonate ABC transporter, substrate-binding protein + Pex19 protein + SprT-like, zinc ribbon domain + PRMT5, oligomerisation domain + Glutathione reductase, eukaryote/bacterial + Potassium-transporting ATPase C chain + GTP cyclohydrolase FolE2/MptA + ATP-grasp fold, DUF201-type + Glutamyl-tRNA reductase, conserved site + Pre-mRNA polyadenylation factor Fip1 + CHASE domain + 6-phosphogluconate dehydrogenase + AMMECR1, N-terminal + Methylmalonic aciduria and homocystinuria type C family + Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, eukaryotic + Dihydrodipicolinate reductase, plant-type + Vasohibin + General secretion pathway protein F + Phage major tail protein TP901-1 + Iron sulphur-containing domain, CDGSH-type + DNA replication licensing factor Mcm7 + Ribonuclease P/MRP protein subunit + Na+/H+ antiporter subunit E + DNA primase, small subunit + Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain + Alpha-2-macroglobulin, thiol-ester bond-forming + Translocon Sec61/SecY, plug domain + Cellulose synthase + Ribosome biogenesis factor NIP7-like + Non-homologous end joining protein Ku, prokaryotic type + Ferredoxin thioredoxin reductase, alpha chain + mRNA triphosphatase Cet1-like + Chorismate mutase, AroQ class, eukaryotic type + Ferredoxin thioredoxin reductase catalytic beta subunit + Serine/threonine-protein kinase, C-terminal + DNA (cytosine-5)-methyltransferase 1, replication foci domain + Domain of unknown function DUF3535 + PucR C-terminal helix-turn-helix domain + Protein of unknown function DUF4169 + Serine proteases, trypsin domain + Galactose-3-O-sulfotransferase + Magnesium chelatase, subunit H, N-terminal + Ribonuclease P/MRP, subunit POP1 + SdiA-regulated + Entericidin A/B + Protein of unknown function DUF3689 + POTRA domain, FtsQ-type + Protein of unknown function DUF3082 + Tubulin-specific chaperone D, C-terminal + Alkyl hydroperoxide reductase subunit F + Nickel/cobalt homeostasis protein RcnB + Ribosomal RNA methyltransferase Spb1, domain of unknown function DUF3381 + ERp29, N-terminal + Formiminotransferase, N-terminal subdomain + L-fucokinase + mRNA splicing factor Cwf21 domain + Protein of unknown function DUF1045 + Dolichol-phosphate mannosyltransferase subunit 3 + Domain of unknown function DUF1713 + Protein of unknown function DUF1712, fungi + CRISPR pre-crRNA endoribonuclease Cas5d + 2-phospho-L-lactate guanylyltransferase, CofC + Piezo non-specific cation channel, R-Ras-binding domain + Fibrillarin + Neutral/alkaline non-lysosomal ceramidase, C-terminal + Alpha-L-fucosidase, C-terminal + RIH (RyR and IP3R Homology) domain + TB domain + Type II secretion system GspD + Pyrimidine-nucleoside phosphorylase, conserved site + Hydroxyisourate hydrolase + Xanthine dehydrogenase, molybdopterin binding subunit + Putative sugar-binding, N-terminal domain + Ribosome biogenesis protein Nop53/GLTSCR2 + DNA polymerase III, subunit gamma/ tau + Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site + Mad1/Cdc20-bound-Mad2 binding protein + Quinohemoprotein amine dehydrogenase, gamma subunit, structural domain + Photosystem II PsbX + Outer membrane protein, OmpW + Uncharacterised protein family FAM98 + Voltage-dependent anion channel + Cytochrome c oxidase assembly protein PET191 + PRTase ComF-like + SANT associated + Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal + Dyskerin-like + Peptidase M54, archaemetzincin + Nitrite reductase [NAD(P)H] small subunit, NirD + M-phase phosphoprotein 6 + tRNA(Met) cytidine acetyltransferase TmcA, N-terminal + Nucleoporin protein Ndc1-Nup + Ribosomal protein S27e + DEP domain + C8orf37 protein + Uncharacterised conserved protein UCP014753 + Type II secretion system protein C, N-terminal + Rhamnosyl O-methyltransferase/Cephalosporin hydroxylase + Acyclic terpene utilisation + Pseudouridine synthase TruD, conserved site + SapC + Ribulose bisphosphate carboxylase, large subunit, ferrodoxin-like N-terminal + Formate dehydrogenase, alpha subunit + Proliferating cell nuclear antigen, PCNA + Lariat debranching enzyme, C-terminal + S-adenosylmethionine decarboxylase family, prokaryotic + Bacterial export protein family 3 + MAGE homology domain + Chs5p-Arf1p binding + Snapin/Pallidin/Snn1 + Nucleolar protein 12 + Signal transduction response regulator, phosphate regulon transcriptional regulatory protein PhoB + Integral membrane protein SYS1-related + Oxysterol-binding protein, conserved site + Tetraspanin/Peripherin + Deoxyhypusine synthase + Enhancer of polycomb-like, N-terminal + Signal recognition particle, SRP19 subunit + Tetratricopeptide, SHNi-TPR domain + PPC domain + Cytochrome C oxidase subunit IV, prokaryotes + Transaldolase type 3B/Fructose-6-phosphate aldolase + Dna2/Cas4, domain of unknown function DUF83 + Protein of unknown function DUF2783 + ChrR-like cupin domain + Nuclear condensin complex subunit 3, C-terminal domain + Sensor protein KdpD, transmembrane domain + Protein of unknown function DUF1287 + PTHB1, N-terminal domain + NIPSNAP + Tubulin binding cofactor A + Protein of unknown function DUF3108 + Zinc finger, Mcm10/DnaG-type + Sorting nexin Vps5-like, C-terminal + Pyridoxal 5'-phosphate synthase subunit PdxS/SNZ + CCR4-Not complex, Not1 subunit, domain of unknown function DUF3819 + Ribonuclease P + Histidine biosynthesis HisG, C-terminal + FAD-binding 9, siderophore-interacting + Type I secretion outer membrane protein, TolC + Polyhydroxyalkanoate synthesis repressor PhaR + Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase + Photosystem II PsbV, cytochrome c-550 precursor + Sof1-like protein + Peptidase, C-terminal, archaeal/bacterial + Fatty acid synthase + Gas2-related domain + Coactivator CBP, KIX domain + Benzoate 1,2-dioxygenase, small subunit + PRMT5, TIM barrel domain + G patch domain-containing protein, N-terminal + Brf1, TBP-binding domain + Formiminotransferase, C-terminal subdomain + Polymorphic outer membrane protein repeat + Ribosomal RNA-processing protein 14, N-terminal + Gingipain propeptide + Protein of unknown function DUF4504 + YmcC-like domain + CRISPR-associated protein Cas1, DVULG subtype + TPX2, C-terminal + PRP1 splicing factor, N-terminal + N-acetylmuramoyl-L-alanine amidase, catalytic domain + NAD kinase + Protein of unknown function DUF1150 + Centromere protein X + Domain of unknown function DUF2007 + Ribosomal protein L10, eubacterial, conserved site + Ribosomal protein L23/L25, N-terminal + Chaperone protein Skp + BRCA2, OB1 + Quinohemoprotein amine dehydrogenase, alpha subunit domain IV + Quinohemoprotein amine dehydrogenase, alpha subunit, haem binding domain + Domain of unknown function DUF3772 + Demeter, RRM-fold domain + CEP76, C2 domain + Mannose-6-phosphate receptor + CC2D2A, N-terminal, C2 domain + Transcription termination and cleavage factor, C-terminal domain + Tellurite resistance methyltransferase TehB-like domain + T-complex protein 1, zeta subunit + T-complex protein 1, theta subunit + T-complex protein 1, eta subunit + Molybdenum cofactor biosynthesis protein B, proteobacteria + DNA-binding, RecF + Cysteine-rich domain + SKI-interacting protein SKIP, SNW domain + RPEL repeat + Phosphoinositide phospholipase C family + Ribosomal protein L10e + PDK1-type, PH domain + Type II secretion system conserved site + FAM183 family + Arylamine N-acetyltransferase + Selenoprotein SelK/SelG + C-protein + Ubiquitin-fold modifier-conjugating enzyme 1 + Cytochrome oxidase assembly protein 1 + DNA replication factor Dna2, N-terminal + Protein of unknown function DUF1479 + Saposin-like type B, region 1 + Uncharacterised conserved protein UCP037205 + TTHA1013/TTHA0281-like + V-type ATPase subunit c domain + DAMP1, SANT/Myb-like domain + CHASE2 + PHB accumulation regulatory + Chlorhexidine efflux transporter + MASE1 + SS18 family + 2-keto-3-deoxy-galactonokinase + Pre-SET domain + Origin recognition complex, subunit 5 + Protein of unknown function DUF883, ElaB + Histone-like protein H-NS, C-terminal domain + Transcription elongation factor Spt6, helix-hairpin-helix motif + Origin recognition complex subunit 4, C-terminal + Asparaginase/glutaminase, active site 1 + Cell division protein FtsA + Cytochrome c oxidase cbb3 type, accessory protein FixG + Protein of unknown function DUF1475 + Glutaredoxin, eukaryotic/virial + Tapt1 family + Toxin CcdB + SNARE-complex protein Syntaxin-18, N-terminal + Retinoblastoma-associated protein, B-box + Repressor of yield of DENV protein + Protein of unknown function DUF2585 + TniQ + Protein of unknown function DUF1116 + Generative cell specific-1, HAP2-GCS1 + Ciliary BBSome complex subunit 2, middle region + Domain of unknown function DUF1971 + Acyl-CoA dehydrogenase, C-termina, bacterial type + E3 UFM1-protein ligase 1 + Protein of unknown function DUF2043 + Protein of unknown function DUF2052, coiled-coil + Domain of unknown function DUF2040 + Domain of unknown function DUF4159 + Pyridoxamine 5-phosphate oxidase, FMN-dependent + Pectate lyase superfamily protein + SAP30-binding protein + Protein KTI12/L-seryl-tRNA(Sec) kinase + Oligopeptidase F, N-terminal domain + 2-phospho-L-lactate transferase + 116kDa U5 small nuclear ribonucleoprotein component, N-terminal + Vacuolar protein sorting 55 + Rad9/Ddc1 + Transcription factor TFIIE beta subunit, DNA-binding domain + Ferrous iron transport protein B, C-terminal + High-CO2 inducible periplasmic + Nucleoside transporter/FeoB GTPase, Gate domain + Protein of unknown function DUF1754, eukaryotic + Vacuolar import/degradation, Vid27-related + Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase + Transmembrane protein DUF1751, eukaryotic + Uncharacterised protein family, Ynq1 + Uncharacterised protein family, CD034/YQF4 + Double transmembrane domain + BCNT-C domain + BRCA1-associated 2 + Protein of unknown function DUF502 + Mitochondrial import inner membrane translocase subunit Tim21 + Transposase IS204/IS1001/IS1096/IS1165, DDE domain + Antirepressor protein, C-terminal + Ribosome maturation protein SBDS, conserved site + Organic solvent tolerance-like, N-terminal + Cdc6, C-terminal + Aspartate racemase + Peptidase M50, putative membrane-associated zinc metallopeptidase + Nucleoside diphosphate pyrophosphatase + Protein of unknown function DUF2933 + Biogenesis of lysosome-related organelles complex-1, subunit 2 + Protein of unknown function UPF0568 + Domain of unknown function DUF2272 + IGR protein motif + DNA/RNA non-specific endonuclease + CDC48, domain 2 + Conserved hypothetical protein CHP03643 + Cytochrome b-c1 complex subunit 8 + Chaperonin ClpB + Clathrin adaptor complex, small chain + Ribosomal protein S7e + Zinc finger, SWIM-type + Coenzyme F420 hydrogenase/dehydrogenase beta subunit, C-terminal + RINT-1/Tip20 + TATA-box binding protein, conserved site + Glyceraldehyde-3-phosphate dehydrogenase, type II + Cytochrome b245, heavy chain + Cytochrome c oxidase copper chaperone + Ribosomal protein/NADH dehydrogenase domain + Ribosomal protein L49/IMG2 + Magnesium-protoporphyrin IX methyltransferase + Peptidase S8 propeptide/proteinase inhibitor I9 + Conjugal transfer, TrbG/VirB9/CagX + Photosystem II CP47 reaction centre protein + Ribonuclease D + Vps16, N-terminal + DNA primase, DnaG + tRNase Z endonuclease + Flagellum biosynthesis repressor FlbT + Laminin EGF domain + Ran GTPase + Adipokinetic hormone, conserved site + Ribonuclease P/MRP, subunit p29 + AMMECR1 domain + Bardet-Biedl syndrome 1, N-terminal + Deaminase, LmjF36.5940-like + Romo1/Mgr2 + Uncharacterised protein family UPF0573/UPF0605 + Fanconi anaemia protein FANCD2 + Exostosin , C-terminal + NADPH-dependent 7-cyano-7-deazaguanine reductase, QueF type 1 + Protein of unknown function DUF2160, transmembrane + Protein of unknown function DUF697 + Potassium channel, calcium-activated, SK + Protein phosphatase 1 regulatory subunit 36 + Protein of unknown function DUF2855 + Kinesin-associated + Peptide Chain Release Factor eRF1/aRF1, N-terminal + Protein MM3350-like domain + Cobalamin (vitamin B12) biosynthesis CobW + Haemerythrin, metal-binding domain + Holin of 3TMs, for gene-transfer release + Carbohydrate binding module, xylan-binding domain + Dopey, N-terminal + S-adenosyl-L-methionine-dependent methyltransferase, putative + Atg6/Beclin + Autophagy-related protein 9 + GPI transamidase component Gaa1 + Nrap protein, domain 5 + GPI transamidase component PIG-T + Iron dependent repressor, metal binding and dimerisation domain + Type II secretion system protein I domain + Peptidase M61, catalytic domain + Iron hydrogenase, small subunit + PQQ-dependent membrane bound dehydrogenase + Alpha-2-macroglobulin, N-terminal 2 + BOP1, N-terminal domain + Ribosomal protein S4e, central region + mRNA capping enzyme, C-terminal + Ribosomal protein S4e, N-terminal + CASP, C-terminal + Protein of unknown function DUF991 + 5-nucleotidase + RNA polymerase archaeal subunit P/eukaryotic subunit RPABC4 + Choloylglycine hydrolase/NAAA C-terminal + Biofilm formation YgiB + Putative small multi-drug export + Protein of unknown function DUF1192 + Sodium-dependent phosphate transport protein + Peptidase S11, D-alanyl-D-alanine carboxypeptidase A + DNA topoisomerase I catalytic fragment, domain 2 + Protein of unknown function DUF3617 + SNU66/SART1 family + GUN4-like + Protein of unknown function DUF3727 + Cbb3-type cytochrome oxidase component + Pre-mRNA splicing factor + Domain of unknown function DUF4461 + Citramalate synthase + Glucose-1-phosphate thymidylyltransferase, short form + Phosphate transport system permease protein PstA + Epsilon tubulin + Prolyl-tRNA synthetase, class IIa, bacterial-type + DNA topoisomerase II, eukaryotic-type + TMC + Photosystem II Pbs27 + Helicase-associated putative binding domain + Major facilitator superfamily associated domain + Sister chromatid cohesion C-terminal domain + RNA 3'-terminal phosphate cyclase type 2 + Ribosomal protein S28e + TonB-system energizer ExbB type-1 + S-adenosylmethionine decarboxylase proenzyme + Alpha-L-arabinofuranosidase, C-terminal + Pyrimidine 5-nucleotidase + Uncharacterised conserved protein UCP012641, putative zinc-binding metallo-peptidase + Conserved hypothetical protein CHP02001 + Manganese catalase, domain 2 + Cbb3-type cytochrome c oxidase subunit CcoP, N-terminal + RNA polymerase II-binding domain + Type IV secretion system protein VirB11 + Timeless protein + Double-strand break repair protein AddB + DNA helicase, AddA type + D-glutamate cyclase + Transcription initiation factor TFIID, subunit 12 + FY-rich, N-terminal + FY-rich, C-terminal + Manganese catalase + Transmembrane protein family 132, middle domain + Ribosomal protein L5 eukaryotic/L18 archaeal + Sedoheptulose-1,7-bisphosphatase + Amidase, carbamoylase-type + TupA-like ATPgrasp protein + Aspartate kinase, monofunctional class + Cytokinin riboside 5'-monophosphate phosphoribohydrolase LOG + DEXH box helicase, DNA ligase-associated + Domain of unknown function DUF2087 + Phenylalanine/histidine ammonia-lyases, active site + Protein of unknown function DUF2794 + Translation initiation factor 3 complex subunit L + Retinoic acid induced 16-like protein + Proteinase inhibitor I46, leech metallocarboxypeptidase inhibitor + Cellulose synthase operon C, C-terminal + B-cell receptor-associated protein 29/31 + Sister chromatid cohesion protein Dcc1 + Exosortase EpsH-related + Signal recognition particle receptor, alpha subunit, N-terminal + Cell shape-determining protein MreD + Cytochrome c oxidase, subunit VIa + Glycine dehydrogenase (decarboxylating) + CCR4-Not complex component, Not1, C-terminal + Cdc23 + Up-frameshift suppressor 2 + Ssl1-like + Cell division control protein 73, C-terminal + Branched-chain amino acid transport, permease + Glycoside hydrolase 35, catalytic domain + Domain of unknown function DUF4942 + Cytochrome c-type biogenesis protein CcsA + RNA polymerase I specific transcription initiation factor RRN3 + Splicing factor RBM39, linker + Uncharacterised protein family 14.7kDa + Neuralized homology repeat (NHR) domain + mRNA-decapping enzyme subunit 1 + KEN domain + Cytochrome c-type biogenesis protein CcmB, bacteria + Peptidase C54 + Peptidase M74, penicillin-insensitive murein endopeptidase + Toluene tolerance Ttg2/phospholipid-binding protein MlaC + Bacterial TniB + T-complex 11 + Uncharacterised conserved protein UCP028101 + Metal-independent alpha-mannosidase + MiaB-like tRNA modifying enzyme, archaeal-type + Transcription regulator YbiH, C-terminal + Inositol-tetrakisphosphate 1-kinase + Uncharacterised conserved protein UCP025560 + Imidazolonepropionase + Agmatinase-related + Chromatin assembly factor 1 subunit A + snRNA-activating protein complex, subunit 3 + Asparagine-tRNA ligase + Aspartate-tRNA synthetase, type 2 + Glutamyl-tRNA synthetase, archaeal/eukaryotic cytosolic + Elongation factor P--(R)-beta-lysine ligase + 3-deoxy-D-manno-octulosonate cytidylyltransferase + Signal recognition particle subunit SRP68 + Peptidase S8A, tripeptidyl peptidase II + Protein of unknown function DUF3752 + 2-oxoisovalerate dehydrogenase, E1 alpha subunit, N-terminal domain + NAD(P) transhydrogenase, alpha subunit + Fanconi Anaemia group E protein, C-terminal + Transcription initiation factor IIA, gamma subunit, C-terminal + Cdk-activating kinase assembly factor MAT1, centre + Uncharacterised protein family UPF0210 + Carboxyltransferase domain, subdomain C and D + Phosducin, thioredoxin-like domain + Integration host factor, beta subunit + ABC transporter, urea permease protein UrtB, bacterial-type + Atrophin-1 + SsrA-binding protein, conserved site + Poly(R)-hydroxyalkanoic acid synthase, class I + AAA ATPase, CDC48 family + Protein of unknown function DUF3611 + (5-formylfuran-3-yl)methyl phosphate synthase + Restriction endonuclease type IV, Mrr + Actin-related protein 2/3 complex subunit 5 + Peroxin-3 + Peroxisome membrane anchor protein Pex14p, N-terminal + Pinin/SDK/MemA protein + WASH complex subunit 7, N-terminal + Protein of unknown function DUF1457 + Eukaryotic translation initiation factor 3 subunit D + Putative glycogen debranching enzyme, N-terminal + Endo-1,3(4)-beta-glucanase + Glycoside hydrolase, family 85 + MOFRL-associated domain + Arf3-interacting protein 1, N-terminal domain + Protein of unknown function DUF1636 + Transcription regulator Myc, N-terminal + Uncharacterised protein family Ycf33 + MnmC-like methyltransferase + PBS lyase HEAT-like repeat + Aspartic peptidase, DDI1-type + Cytochrome c oxidase caa3-type, assembly factor CtaG-related + CCR4-Not complex component, Not N-terminal domain + Actin-related protein 2/3 complex subunit 3 + 4Fe-4S domain + Na(+)/H(+) antiporter subunit F-like + Lamin Tail Domain + Photosystem II cytochrome b559, alpha subunit, lumenal region + Replication origin-binding protein + Pre-mRNA-splicing factor 3 + Yos1-like + Protein of unknown function DUF1764, eukaryotic + Domain of unknown function DUF4392 + Nrap protein, domain 3 + Anti-sigma-28 factor FlgM, C-terminal + DMSO/Nitrate reductase chaperone + DNA primase, small subunit, eukaryotic/archaeal + Phosphate-starvation-induced PsiE-like + Addiction module antidote protein, HI1420 + Addiction module killer protein, predicted + Bacteriophage regulatory protein, Rha family + Heme D1 biosynthesis, radical SAM protein NirJ + Translation initiation factor 2, alpha subunit + Eukaryotic translation initiation factor 3-like domain + Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase, N-terminal + MerC mercury resistance protein + Suppressor of forked + Pyruvate/ketoisovalerate oxidoreductase, catalytic domain + Proline-specific peptidase + Succinyl-diaminopimelate desuccinylase, proteobacteria + Anthranilate phosphoribosyl transferase + U1 small nuclear ribonucleoprotein of 70kDa N-terminal + Multicopper oxidase, type 1 + Ribosomal RNA-processing protein 15 + Protein of unknown function DUF1656 + Protein of unknown function DUF1236 + Heat shock factor binding 1 + Protein of unknown function DUF3337 + Protein of unknown function DUF3342 + ATP-grasp fold, RimK-type + LPS export ABC transporter, ATP-binding protein LptB + LPS export ABC transporter permease LptF + Peptide chain release factor 3 + Acetyl-CoA carboxylase, biotin carboxylase + Prp18 + TMEM33/Pom33 family + Glucosamine-6-phosphate isomerase + Ribosomal protein S12e + Glycerol-3-phosphate dehydrogenase, NAD-dependent, eukaryotic + ATPase, type I secretion system + Magnesium-protoporphyrin IX methyltransferase, C-terminal + Malate dehydrogenase, type 2 + LOR/SDH bifunctional enzyme, conserved domain + Poly(A) polymerase, RNA-binding domain + O-antigen ligase-related + Mediator complex, subunit Med6 + Cystathionine beta-lyase, bacterial + Cystathionine beta-lyase, eukaryotic + SF3A2 domain + FixG, C-terminal immunoglobulin-like domain + Vacuole morphology and inheritance protein 14, Fab1-binding region + U3 small nucleolar RNA-associated protein 6 + Mediator complex, subunit Med14 + RNA 3'-terminal phosphate cyclase-like, conserved site + LEM/LEM-like domain + AraC-type transcription regulator, ligand-binding domain + Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site + Bacterioferritin + CG-1 DNA-binding domain + Kinetochore protein Ndc80 + LydA-like holin + Riboflavin biosynthesis protein RibD + Centrosomal protein of 19kDa + Periplasmic protein thiol:disulphide oxidoreductase DsbE + Protein of unknown function DUF4498 + Tricorn protease, PDZ domain + Nuclear protein 96 + Splicing factor SF3a60 binding domain + Ribosomal protein S24/S35, mitochondrial, conserved domain + Fanconi anemia complex, subunit FancL, WD-repeat containing domain + K+ transporting P-type ATPase, F subunit + GSCFA + Domain of unknown function DUF4131 + Carbamoyltransferase + Gluconate transporter + mRNA interferase PemK-like + Quinolinate synthetase A + Peptidase C15, pyroglutamyl peptidase I-like + Protein of unknown function DUF535 + Stringent starvation protein B + Malonyl-CoA decarboxylase, C-terminal + Cobaltochelatase subunit CobS + Ribosomal protein L39e + Domain of unknown function DUF4982 + Deoxycytidine triphosphate deaminase, bacterial + Transcription factor IIA, beta-barrel + HemY, N-terminal + SepSecS/SepCysS family + S-adenosylmethionine decarboxylase + Bacterial glucose/galactose transporter + D-cysteine desulfhydrase + Phenylalanine-4-hydroxylase, monomeric form + Glycosyl hydrolase family 99 + Fructose-bisphosphate aldolase class-I active site + Diphosphomevalonate decarboxylase + Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site + Uncharacterised protein family Ycf35 + RNA polymerase I associated factor, A49-like + Transmembrane protein 43 family + Glutamate-cysteine ligase catalytic subunit + Acetamidase/Formamidase + Pca transcription factor PcaQ + Zinc finger, C4 DksA/TraR-type + 4-carboxymuconolactone decarboxylase + Isochorismate synthase + Copper amine oxidase + DNA-directed RNA polymerase, subunit N/Rpb10 + Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term + Nucleolar pre-ribosomal-associated protein 1, N-terminal + Gemini of Cajal bodies-associated protein 8 + Condensin-2 complex subunit G2 + Pyridoxamine 5'-phosphate oxidase-related + TFIIH subunit Tfb4/p34 + Class I myosin tail homology domain + Conjugal transfer TrbC/type IV secretion VirB2 + Protein of unknown function UPF0178 + VPS13, repeated coiled region + Nrap protein, domain 2 + RAI1-like + Mon2, C-terminal + Oligosaccharide biosynthesis protein Alg14-like + SbsA, Ig-like domain + Vacuolar membrane-associated protein Iml1 + Chromosome segregation protein Spc25 + Chromosomal replication control, initiator DnaA-like + Gamma-glutamyl phosphate reductase GPR, conserved site + Ribosomal protein S16, conserved site + Protein of unknown function DUF2271 + Tyrosinase copper-binding domain + Catalase haem-binding site + Photosystem II cytochrome b559, alpha subunit + Methionyl-tRNA formyltransferase + Tab2-like + DNA polymerase III, delta subunit + Protein translocase subunit SecD + Chaperonin GroES, conserved site + KorB, C-terminal + rRNA biogenesis protein RRP36 + RNA polymerase, Rpb5, N-terminal + RNA polymerase II, Rpb4 + Gamma-secretase subunit Aph-1 + Yif1 family + Cgr1-like + Protein of unknown function DUF4639 + N-acetyl-gamma-glutamyl-phosphate reductase, active site + Clathrin, heavy chain, propeller repeat + Ribosomal protein S23/S29, mitochondrial + DNA primase/polymerase, bifunctional, N-terminal + Histone PARylation factor 1 + PDZ-binding protein, CRIPT + Nuclear fragile X mental retardation-interacting protein 1, conserved domain + Cactin, central domain + Nuclear protein DGCR14 + Mediator complex, subunit Med10 + Mini-chromosome maintenance complex-binding protein + 3-dehydroquinate dehydratase type I + Ras guanine-nucleotide exchange factors catalytic domain + Malic oxidoreductase + RNA-binding, CRM domain + Retinoblastoma-associated protein, N-terminal + Ribonuclease, PIN domain + FANCI helical domain 2 + KHA domain + U3 small nucleolar ribonucleoprotein complex, subunit Mpp10 + TFIIH subunit Ssl1/p44 + Free Met sulfoxide reductase conserved site + Virulence-associated E + CST complex subunit Ten1, animal and plant type + FACT complex subunit Spt16, N-terminal lobe domain + Ribosomal protein L31e + Uncharacterised protein family Ycf34 + Ribosome maturation protein Sdo1/SBDS + Cancer susceptibility candidate 1, N-terminal + HAD-superfamily phosphatase, YqeG-like + Galactonolactone dehydrogenase + Orotidine 5'-phosphate decarboxylase, type 2 + ATP11 + GPI transamidase subunit PIG-U + Domain of unknown function DUF302 + LsmAD domain + Cas1p 10 TM acyl transferase domain + Transcription elongation factor, GreA/GreB, conserved site + Glycosyltransferase, ALG3 + Glutaredoxin-like + Dicarboxylate transport + Vacuolar protein sorting protein 11, C-terminal + Domain of unknown function DUF2235 + Protein of unknown function DUF3604 + GspF/PilC family + BON domain + CHORD domain + DNA-directed RNA polymerase, 30-40kDa subunit, conserved site + Nuclear-interacting partner of ALK/Rsm1-like + Eukaryotic translation initiation factor 3 subunit J + Helicase XPB/Ssl2, N-terminal domain + Rab3-GAP regulatory subunit, N-terminal + Methanolan biosynthesis EpsI + Cyanovirin-N + Nucleoporin Nup85-like + Nucleolar complex-associated protein 3, N-terminal + Orotate phosphoribosyltransferase, bacterial + Acetyl-S-ACP:malonate ACP transferase + UTP--glucose-1-phosphate uridylyltransferase, bacterial/archaeal-type + ATPase, V1 complex, subunit F, eukaryotic + AVL9/DENND6 domain + Aromatic amino acid hydroxylase, iron/copper binding site + Domain of unknown function DUF4520 + WASH complex subunit 7, C-terminal + WASH complex subunit 7, central domain + Domain of unknown function DUF5001 + Fis1, C-terminal tetratricopeptide repeat + DNA polymerase epsilon, catalytic subunit A, C-terminal + General secretion pathway, GspH + WHG domain + Periplasmic binding protein + Transmembrane protein 231 + WASH complex subunit 3 + PRONE domain + Vitelline membrane outer layer protein I (VOMI) + Cryptochrome DASH + DNA photolyase class 2 + Ribonuclease H2, subunit A + DNA/RNA-binding domain, Est1-type + Co-chaperone Hsc20 + Domain of unknown function DUF4126 + Domain of unknown function DUF4115 + Cellular retinaldehyde binding/alpha-tocopherol transport + O-methyltransferase, family 2 + Domain of unknown function DUF4365 + Ribosomal protein L19/L19e, domain 2 + Ribosomal protein L19/L19e, domain 3 + Arsenical pump ATPase, ArsA/GET3 + DNA helicase (DNA repair), Rad3 type + Glucan biosynthesis, periplasmic, MdoG C-terminal + SAGA complex, Sgf11 subunit + SCA7 domain + DNA-directed RNA polymerase I, subunit RPA34.5 + Uncharacterised protein family UPF0220 + RNA-binding motif protein 8 + Lipocalin-like domain + Rare lipoprotein A + Alkylbase DNA glycosidase, conserved site + Peptidase A24A, N-terminal + Domain of unknown function DUF4743 + HicB-like antitoxin of toxin-antitoxin system + MTA/SAH nucleosidase + HAD-superfamily hydrolase, subfamily IIA, CECR5 + Crotonyl-CoA reductase + Bifunctional uridylyltransferase/uridylyl-removing enzyme + Oxidoreductase alpha (molybdopterin) subunit + Peptidase A24A, prepilin type IV, bacterial + Dihydropteroate synthase + Splicing factor 3B subunit 5/RDS3 complex subunit 10 + Mutator MutT + Lipase, GDXG, putative histidine active site + Pyridoxal 5'-phosphate synthase subunit PdxT/SNO + Type III secretion system substrate exporter + Serine/threonine-protein kinase SMG1 + Chemotaxis methyl-accepting receptor + Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain + Protein of unknown function DUF4598 + Tetratricopeptide TPR-3 + RbsD-like domain + Bacteriophage lambda, GpH, tail tape measure, N-terminal + CagE, TrbE, VirB component of type IV transporter system + Aerotolerance regulator, N-terminal + PTP type protein phosphatase + Sortilin, N-terminal + Alcohol ABC transporter, permease protein + Acyl-CoA-binding protein, ACBP, conserved site + GPR domain + Protein of unknown function DUF1749 + DNA polymerase family X, binding site + EcsC protein + Translin, N-terminal + Glycoside hydrolase, family 59 + LicD family + Photosystem I PsaL, reaction centre subunit XI + Putative RNA methyltransferase + Rad1/Rec1/Rad17 + Succinylarginine dihydrolase + Mannose-6-phosphate isomerase, type II, C-terminal + Acetylserotonin O-methyltransferase, dimerisation domain + Coilin, N-terminal domain + RNA polymerase II-associated protein 1, C-terminal + Mediator complex, subunit Med20 + Protein of unknown function DUF898 + Na+-dependent bicarbonate transporter superfamily + Uncharacterised protein family CreA + Protein of unknown function DUF1003 + LPPG:FO 2-phospho-L-lactate transferase CofD/UPF0052 + Small-subunit processome, Utp14 + Rad4 beta-hairpin domain 2 + Rad4 beta-hairpin domain 1 + Glucosamine-6-phosphate isomerase, conserved site + DNA polymerase 1 + Rad4 beta-hairpin domain 3 + 60S ribosomal protein L4, C-terminal domain + Ubiquitin carboxyl-terminal hydrolase 7, ICP0-binding domain + Anti-proliferative protein + Flagellar motor switch protein FliG, N-terminal domain + Fic/DOC N-terminal + AP-4 complex subunit epsilon-1, C-terminal + Beta-galactosidase, domain 3 + N-acetyltransferase ESCO, acetyl-transferase domain + Ribosomal protein L13, eukaryotic/archaeal + Neurochondrin + Cobalamin biosynthesis CobD/CbiB + Cobalamin-independent methionine synthase MetE, C-terminal/archaeal + Protein of unknown function DUF2373 + RNA polymerase II assembly factor Rtp1, C-terminal + BLOC-1-related complex subunit 8 + Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 2 + Telomerase activating protein Est1 + GPI-GlcNAc transferase complex, PIG-H component, conserved domain + Homoserine kinase, type II + Lysosomal cystine transporter + L-aspartate oxidase + CST complex subunit Stn1, N-terminal + Transcription termination factor Rho + Borealin, N-terminal + Ribosomal S6 modification enzyme RimK/Lysine biosynthesis enzyme LysX + Collagen triple helix repeat + Small nuclear RNA activating complex (SNAPc), subunit SNAP43 + Ribosomal protein L27/L41, mitochondrial + N-acetyltransferase B complex, non-catalytic subunit + Anticodon-binding domain + Photosystem II PsbH, phosphoprotein + Ribosomal protein S13/S15, N-terminal + Cytochrome c oxidase biogenesis protein Cmc1-like + LL-diaminopimelate aminotransferase + RAD3/XPD family + Glycoside hydrolase, family 35 + tRNA-splicing endonuclease, subunit Sen54, N-terminal + MOZART2 family + Nucleolar GTP-binding protein 2, N-terminal domain + Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site + tRNA 2-selenouridine synthase + Tagatose/fructose phosphokinase + Sporulation stage V, protein R + mRNA splicing factor SYF2 + Aliphatic sulfonates-binding protein + Bacteriophage HK97-gp10, putative tail-component + Type II secretion system protein H + Ribbon-helix-helix protein, CopG + ZC3H15/TMA46 family, C-terminal + Vesiculovirus matrix + Biogenesis of lysosome-related organelles complex 1 subunit 1 + Type II secretion system protein M, periplasmic domain + Ethanolamine ammonia-lyase light chain + Type II secretion system, protein N + Asp/Glu racemase, active site 2 + Domain of unknown function DUF3441 + Vacuolar protein 14 C-terminal Fig4-binding domain + Proteasome activator complex subunit 4 C-terminal domain + STAG + Two-component sensor kinase, N-terminal + Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, N-terminal + Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, dimerisation domain + Phospholipase D/Transphosphatidylase + Peptidase S26B + Phosphotriesterase + FANCI solenoid 1 domain + Intraflagellar transport protein 43 + Phosphoribosylglycinamide formyltransferase, active site + Gemin2/Brr1 + Spt6, SH2 domain + Fanconi anemia group F protein + Nucleoporin Nup186/Nup192/Nup205 + RES domain + N-terminal acetyltransferase A, auxiliary subunit + Adenosine kinase + ATP synthase, F1 complex, epsilon subunit, mitochondrial + Para-hydroxybenzoic acid efflux pump subunit AaeB/fusaric acid resistance protein + THO complex, subunit THOC1 + RAVE subunit 2/Rogdi + Carbon monoxide dehydrogenase subunit G + Methyltransferase, Rta_06860 family + tRNA (mo5U34)-methyltransferase-like + Proteasome activator Blm10, mid region + Radical SAM, C-terminal extension + Band 7, C-terminal extension + Nucleolar pre-ribosomal-associated protein 1, C-terminal domain + ERCC3/RAD25/XPB helicase, C-terminal domain + Histone-like protein H-NS + Zinc finger, LSD1-type + Serpin, conserved site + Orotate phosphoribosyl transferase domain + Replication gene A protein + Sirohaem synthase, dimerisation domain + Peroxiredoxin, C-terminal + Transcription factor TFIID, subunit 8, C-terminal + DNA primase, DnaB-helicase binding domain + Protein of unknown function DUF4464 + Para-aminobenzoate synthase, component I + DNA recombination/repair protein RecN + Signal peptidase complex subunit 2 + Proliferating cell nuclear antigen, PCNA, conserved site + Cell morphogenesis protein C-terminal + Domain of unknown functionDUF2779 + RPGR-interacting protein 1, first C2 domain + Group 4 capsule polysaccharide formation lipoprotein GfcB + Protein of unknown function DUF4238 + Protein of unknown function DUF4239 + Aconitase B, HEAT-like domain + Ribosomal protein L13e + DeoR-type HTH domain + Mitochondrial import receptor subunit TOM7 + Protein of unknown function DUF2214, membrane + Maltose/galactoside acetyltransferase + MMS19, C-terminal + Spp2/MOS2, G-patch domain + Inhibin, beta B subunit + Asparagine synthase + Peptidase S11, D-alanyl-D-alanine carboxypeptidase A, N-terminal + Coiled-coil domain-containing protein 90-like + Glycosyl-hydrolase family 116, N-terminal + Domain of unknown function DUF2384 + DIRP domain + Putative hydrolase RBBP9/YdeN + Lipopolysaccharide assembly, LptC-related + Serine-threonine protein kinase 19 + RLI1 + Bacteriophage KVP40, Orf299 + Anaphase-promoting complex, subunit CDC26 + Phosphoglucosamine mutase, bacterial type + Polysaccharide biosynthesis protein + Domain of unknown function DUF89 + HAT (Half-A-TPR) repeat + Condensin II complex subunit H2, N-terminal + NADH:ubiquinone/plastoquinone oxidoreductase, chloroplast chain 5, C-terminal + Cytochrome c oxidase, subunit Vb + Quinohemoprotein amine dehydrogenase, alpha subunit, domain 2 + DDE superfamily endonuclease domain + Cytochrome c-550 domain + Domain of unknown function DUF4433 + Ribonuclease Zc3h12a-like, NYN domain + ATP-dependent DNA helicase RecG, C-terminal domain + Topoisomerase I C-terminal domain + Serpin domain + Cancer susceptibility candidate protein 1 + Quinoprotein dehydrogenase-associated + Transmembrane protein 131-like + Sterol methyltransferase C-terminal + Molybdate ABC transporter, substrate-binding protein + Protein of unknown function DUF2491 + Uncharacterised protein family HI1736/YgjV + P-type trefoil, conserved site + RecD helicase-like helix-hairpin-helix domain + Recombination protein O, RecO + Phosphoenolpyruvate carboxylase + Flagellar hook-length control protein-like, C-terminal + Glycoside hydrolase, chitinase active site + Translation initiation factor 3, subunit 12, N-terminal, eukaryotic + Protein of unknown function DUF3007 + Ribosomal protein L19/L19e + Ferrous iron transporter FeoA domain + Phage shock protein, PspC + ATPase, V0 complex, c/d subunit + ATPase, V1/A1 complex, subunit E + Coenzyme F420:L-glutamate ligase-like domain + Protein of unknown function DUF599 + Translin family + Clathrin light chain + Domain of unknown function DUF4787 + MAM domain + Urocanase, C-terminal domain + Urocanase, N-terminal domain + Protein of unknown function DUF1028 + Phage-integrase repeat unit + 5-histidylcysteine sulfoxide synthase + Thiaminase II + CAAX prenyl protease 1, N-terminal + SMARCC, C-terminal + Uncharacterised domain UPF0702, alpha/beta domain + Ribosomal protein S5/S7, eukaryotic/archaeal + Ribosomal protein S4/S9, eukaryotic/archaeal + Ribosomal protein S5, eukaryotic/archaeal + Photosystem II D2 protein + Photosystem II CP43 reaction centre protein + ATP synthase, F0 complex, subunit b, bacterial + Photosystem II protein D1 + DNA mismatch repair protein Mlh1, C-terminal + Ribosomal protein L23/L25, conserved site + Myristoyl-CoA:protein N-myristoyltransferase, C-terminal + Hexokinase, N-terminal + Hexokinase, C-terminal + Myristoyl-CoA:protein N-myristoyltransferase, conserved site + Peptidase C14A, caspase catalytic domain + Inosine/uridine-preferring nucleoside hydrolase, conserved site + Protein of unknown function DUF2252 + Abortive bacteriophage infection, resistance + Glycosyl transferase WecB/TagA/CpsF + Mannonate dehydratase + PhnA protein + Head decoration protein D + Glycoside hydrolase, family 13, N-terminal + 5,10-methylenetetrahydrofolate reductase + UNC-45/Cro1/She4, central domain + Protein of unknown function DUF2927 + Protein of unknown function DUF2934 + SLC26A/SulP transporter + Polyamine biosynthesis domain, conserved site + Protein of unknown function DUF484 + Coatomer, gamma subunit, appendage, Ig-like subdomain + Meiotic recombination, Spo11 + Helical and beta-bridge domain + Low temperature requirement A + Polysaccharide pyruvyl transferase + Zinc finger, C2H2, LYAR-type + Deoxyribodipyrimidine photolyase-related protein + Uncharacterised protein YjbR + Protein of unknown function DUF421 + 26S proteasome non-ATPase regulatory subunit 5 + 2-phosphoglycolate phosphatase, prokaryotic + Phosphorylase pyridoxal-phosphate attachment site + Plasmid conjugal transfer TrbL/VirB6 + Uncharacterised protein family UPF0102 + Translation initiation factor IF6 + Ran-interacting Mog1 protein + YutG/PgpA domain + Sugar-phosphate isomerase, RpiB/LacA/LacB family + Tannase/feruloyl esterase + ATPase, V1 complex, subunit C + DNA topoisomerase I, catalytic core, alpha/beta subdomain + Peptidase U32, collagenase + Phenylacetic acid degradation B + Sulphate adenylyltransferase, large subunit + Hydantoinase/dihydropyrimidinase + Magnesium chelatase, ATPase subunit I + Magnesium chelatase, ATPase subunit D + Magnesium-chelatase, subunit H + Ribonuclease R + Beta-1,4-galactosyltransferase + Signal transduction histidine kinase, osmosensitive K+ channel sensor, N-terminal + Ribosomal protein L27e, conserved site + Beta tubulin + Gamma tubulin + Transcription elongation factor Spt5, NGN domain + Senescence/spartin-associated + Winged helix-turn-helix transcription repressor, HrcA DNA-binding domain + Protein of unknown function DUF1280 + Paf1 complex subunit Cdc73, N-terminal domain + Uncharacterised protein family UPF0227/Esterase YqiA + Procyclic acidic repetitive + Ribosomal protein S27e, zinc-binding domain + RNA (C5-cytosine) methyltransferase, subfamily 9 + Pre-rRNA-processing protein RIX1, N-terminal + Protein of unknown function DUF3667 + Exosome-associated factor Rrp6, N-terminal + Lipase, GDSL, active site + Misato Segment II tubulin-like domain + Oxoglutarate/iron-dependent oxygenase, C-terminal degradation domain + Hemin uptake protein HemP + Kinase associated domain 1 (KA1) + Beta-catenin-like protein 1, N-terminal + N-acetylglucosaminyl phosphatidylinositol deacetylase-related + Metal-sensitive transcriptional repressor + Pyridoxal-phosphate binding site + Raptor, N-terminal CASPase-like domain + Ubiquitin carboxyl-terminal hydrolase, C-terminal + PhnA protein, N-terminal + Phospholipase C/D + CENP-S/Mhf1 + Protein of unknown function DUF1825 + Protein of unknown function DUF1826 + Protein of unknown function DUF1824 + Cytochrome f large domain + Proline dehydrogenase PutA, domain I + Transcription initiation factor IIF, beta subunit + Small-subunit processome, Utp11 + Leo1-like protein + NADPH-dependent F420 reductase + Acyl-ACP thioesterase + Quinohemoprotein amine dehydrogenase, alpha subunit domain III + Iodothyronine deiodinase + 2',3'-cyclic-nucleotide 3'-phosphodiesterase + Tricorn protease C1 domain + Photosynthesis system II assembly factor Ycf48/Hcf136-like domain + Ciliary BBSome complex subunit 2, N-terminal + Microvirus J protein-like + Cox20/FAM36A + Ubiquitously expressed transcript protein UXT + RTX toxin determinant A + Adenylate dimethylallyltransferase + Uncharacterised protein family UPF0642 + Translocon-associated protein (TRAP), alpha subunit + Ribosomal protein S23/S25, mitochondrial + Exosortase/Archaeosortase domain + Isocitrate lyase/phosphorylmutase, conserved site + DNA/RNA non-specific endonuclease, active site + 5-methylcytosine restriction system component + tRNA pseudouridine synthase II, TruB, subfamily 1, C-terminal + Luciferase-like, F420-dependent oxidoreductase, Rv2161c, predicted + Protein of unknown function DUF1365 + Lysyl oxidase + Nitrile hydratase alpha /Thiocyanate hydrolase gamma + Tetrapyrrole biosynthesis, glutamyl-tRNA reductase + Putative glutamine amidotransferase type 2 + Protein of unknown function DUF2961 + Protein of unknown function DUF3228 + TRAPP III complex, Trs85 + Rubredoxin domain + RED-like, N-terminal + Plasmid pRiA4b, Orf3 + Chromatin modification-related protein Eaf6 + SUN domain + Adenylosuccinate lyase PurB, C-terminal + PUL domain + Alpha-L-fucosidase, metazoa-type + ATP-NAD kinase, PpnK-type, all-beta + Domain of unknown function DUF3641 + Outer membrane autotransporter barrel + Dyp-type peroxidase + Sec-independent protein translocase protein TatA/E + L-threonine dehydratase biosynthetic IlvA + Mediator of RNA polymerase II transcription subunit 22 + Protein of unknown function DUF993 + Nuclear cap-binding protein subunit 3 + CDC45 family + Helicase domain + Cytochrome b6-f complex subunit 6 + Protein of unknown function DUF4804 + Mitochondrial PGP phosphatase + Deoxyribose-phosphate aldolase + Double zinc ribbon + Protein RETICULATA-related + Protein of unknown function DUF3419 + UPF3 domain + Vacuolar (H+)-ATPase G subunit + Protein of unknown function DUF3684 + Tuftelin interacting protein, N-terminal domain + Protein of unknown function DUF2723 + Protein of unknown function DUF4202 + S100/Calbindin-D9k, conserved site + Protein of unknown function DUF779 + Rho protein GDP-dissociation inhibitor + Polyamine-modulated factor 1/Kinetochore protein NNF1 + Peptidase S13, D-Ala-D-Ala carboxypeptidase C + Cyclohexanecarboxyl-CoA dehydrogenase + 2-ketocyclohexanecarboxyl-CoA hydrolase + Catechol 2,3 dioxygenase + Conserved hypothetical protein CHP03214, putative allantoin-urate catabolism protein + Formamidopyrimidine-DNA glycosylase + Nucleolar, Nop52 + Cysteine dioxygenase type I + TRP-like family + FAR-17a/AIG1-like protein + Divergent polysaccharide deacetylase + Transcription regulator HTH, AraC- type + Domain of unknown function DUF4455 + ATP synthase YMF19-like, N-terminal + Cytochrome ubiquinol oxidase subunit 2 + Trans-aconitate 2-methyltransferase, C-terminal + Urocanase + Urocanase conserved site + Co-chaperone HscB, C-terminal oligomerisation domain + Dehydroquinase, class II, conserved site + EB1, C-terminal + Urease accessory protein UreG + Peptide chain release factor eRF1/aRF1 + Glucose-fructose oxidoreductase, bacterial + Phosphatidate cytidylyltransferase, mitochondrial + Alpha-2-glucosyltransferase Alg10 + Histidine phosphotransferase ChpT, C-terminal + TFIIH subunit TTDA/Tfb5 + Kri1-like, C-terminal + Domain of unknown function DUF2846 + NADH:ubiquinone oxidoreductase, B18 subunit + HicA mRNA interferase family + Zinc finger, C3HC-like + H-type lectin domain + Eukaryotic translation initiation factor 3 subunit E, N-terminal + Vacuolar ATPase assembly integral membrane protein Vma21 + Protein of unknown function DUF2474 + Ribulose bisphosphate carboxylase small chain, domain + Transthyretin/hydroxyisourate hydrolase + Ribosomal protein S26e + Aliphatic acid kinase, short-chain + Scaffold protein D + Eukaryotic-type methylenetetrahydrofolate reductase + Ubiquinol cytochrome reductase, transmembrane domain + Non-structural maintenance of chromosome element 4, C-terminal + Helicase HerA, central domain + H/ACA ribonucleoprotein complex, subunit Nhp2, eukaryote + Adenosine/adenine deaminase + Coenzyme PQQ biosynthesis protein C + Coenzyme PQQ biosynthesis protein E, bacteria + Interferon alpha-inducible protein 6/27 + Ribosomal RNA processing protein 8 + Photosystem II PsbM + Microcystin LR degradation protein MlrC, C-terminal + Prenylcysteine lyase + Ribosomal protein S4e, N-terminal, conserved site + Tweety + Formylmethanofuran: tetrahydromethanopterin formyltransferase Ftr, ferredoxin-like domain + Ribosomal protein L24e, conserved site + DNA replication licensing factor Mcm6 + DNA replication licensing factor Mcm + D-ribose pyranase RbsD/L-fucose mutarotase FucU + Endoribonuclease XendoU + RNA helicase UPF1, UPF2-interacting domain + DNA replication licensing factor Mcm2 + FGFR1 oncogene partner (FOP), N-terminal dimerisation domain + Mini-chromosome maintenance complex protein 4 + DNA replication licensing factor Mcm3 + mRNA decapping protein 2, Box A domain + Timeless C-terminal + SPARC/Testican, calcium-binding domain + Splicing factor 3B subunit 1 + Uncharacterised protein family UPF0564 + Transcription factor LuxR-like, autoinducer-binding domain + Coenzyme F420:L-glutamate ligase + Cation efflux system CzcA/CusA/SilA/NccA/HelA/CnrA + Origin recognition complex, subunit 3 + PdxS/SNZ N-terminal domain + Exosome complex component, N-terminal domain + GAG-pre-integrase domain + Domain of unknown function DUF4174 + Glycoside hydrolase family 18, catalytic domain + Legume lectin domain + DBP10, C-terminal + GINS subunit, domain A + Iron-sulphur-dependent L-serine dehydratase single chain form + Helix-turn-helix, type 11 + Protein of unknown function DUF4591 + GCK + RNA polymerase II, heptapeptide repeat, eukaryotic + Type II secretion system GspE + Peptidase M22, conserved site + F-actin capping protein, alpha subunit, conserved site + 3-hydroxyanthranilic acid dioxygenase + Exocyst complex component EXOC3/Sec6 + HDIG domain + Sin3, C-terminal + MraZ domain + Ribosomal protein L6, conserved site-2 + dTDP-glucose 4,6-dehydratase + Serine O-acetyltransferase + Zinc finger, DksA/TraR C4-type, bacteria + Ribonuclease HII, helix-loop-helix cap domain + Protein of unknown function DUF1127 + Ribosomal protein S25 + Eukaryotic translation initiation factor 3 subunit C, N-terminal domain + Proteasome assembly chaperone 3 + COG complex component, COG2, C-terminal + Protein of unknown function DUF2608 + Ribosome maturation protein SBDS, N-terminal + BING4, C-terminal domain + Sde2 N-terminal domain + BP28, C-terminal domain + CPL domain + UreE urease accessory, N-terminal + Mago nashi protein + Phthalate dioxygenase reductase + Ada DNA repair, metal-binding + Transcription regulator YcdC, C-terminal + DNA polymerase subunit Cdc27 + Tafazzin + Schlafen, AAA domain + Anti-sigma factor antagonist + RelB antitoxin/Antitoxin DinJ + GTP cyclohydrolase I + Quinoprotein dehydrogenase, conserved site + Choline ABC transporter, substrate-binding protein + ABC transporter, urea, ATP-binding protein, UrtD + ABC transporter, choline, permease protein + CRM1 C-terminal domain + Urea transporter + RFT1 + Anaphase-promoting complex subunit 2, C-terminal + MiaB-like tRNA modifying enzyme + ATPase assembly factor ATP10 + HEPN domain + RNA-recognition motif (RRM) Nup35-type domain + L-asparaginase, C-terminal domain + Asparaginase/glutaminase, active site 2 + Ribulose bisphosphate carboxylase, large chain, active site + Molybdate ABC transporter, ATP-binding protein + Sulphate ABC transporter, permease protein CysT + Phosphate ABC transporter, permease protein PstC + Molybdate ABC transporter, permease protein + Sas10 C-terminal domain + Cytochrome b-c1 complex subunit 9 + Ribosome maturation protein SBDS, C-terminal + Allantoicase + Ku70/Ku80 C-terminal arm + CDKN3 domain + TRM13/UPF0224 family, U11-48K-like CHHC zinc finger domain + Wings apart-like protein + ThiC-associated domain + Cleavage stimulation factor subunit 2, hinge domain + FlgD Ig-like domain + N-acetyltransferase ESCO, zinc-finger + Micro-fibrillar-associated protein 1, C-terminal + Mitochondrial degradasome RNA helicase subunit, C-terminal domain + Protein of unknown function DUF3293 + Pre-mRNA splicing Prp18-interacting factor + Ribosomal protein S1 + Signal recognition particle, SRP72 subunit, RNA-binding + mRNA splicing factor, Cwf18 + Conserved oligomeric Golgi complex, subunit 4 + SPFH domain, YdjI-like + Type I secretion membrane fusion protein, HlyD family + Phasin, subfamily 1 + Pyruvate, phosphate dikinase + Ribonucleotide reductase, adenosylcobalamin-dependent + Domain of unknown function DUF403 + Transcription activator PspF + Succinate dehydrogenase, hydrophobic membrane anchor + Phage shock protein, PspA + Adenosine/AMP deaminase active site + Photosystem I Ycf4, assembly + Bacteriochlorophyll/chlorophyll synthetase + Phosphotransferase system, fructose-specific IIB subunit + Uncharacterised protein family UPF0066, conserved site + Uncharacterised domain, di-copper centre + Flagellar hook-associated protein 1 + ETC complex I subunit + Sec20 + Erg28 + ISWI, HAND domain + Peptide-N-glycosidase F, C-terminal + Peptide-N-glycosidase F, N-terminal + Translation elongation factor SelB, winged helix, type 3 + Phosphoenolpyruvate carboxykinase (ATP), conserved site + CofH family + Uncharacterised domain NUC130/133, N-terminal + Arginine N-succinyltransferase AstA/AruG + DNA-directed RNA polymerase, subunit beta'' + NOG, C-terminal + DNA-directed RNA polymerase, subunit beta-prime + DNA-directed RNA polymerase, subunit gamma + RNA polymerase sigma factor RpoH, proteobacteria + NAD-dependent DNA ligase + C4-type zinc-finger of DNA polymerase delta + Bacterial periplasmic spermidine/putrescine-binding protein + Thiosulfohydrolase SoxB + Sulfur oxidation c-type cytochrome SoxX + TusA-like domain + Thiosulfate oxidation carrier complex protein SoxZ + GRASP55/65 PDZ-like domain + SSRP1 domain + tRNAHis guanylyltransferase catalytic domain + Siderophore-interacting protein + Primase, C-terminal 2 + tRNA (1-methyladenosine) methyltransferase catalytic subunit Gcd14 + Guanine nucleotide-binding protein-like 3, N-terminal domain + Fcf2 pre-rRNA processing + SRP40, C-terminal + Urease accessory protein UreE, C-terminal domain + Hypoxia-inducible factor 1-alpha inhibitor, domain II + F-actin-capping protein subunit alpha + Maltose transport system permease protein MalF N-terminal domain + Domain of unknown function DUF4537 + Domain of unknown function DUF4515 + Ribosomal protein S6, conserved site + Zeta-carotene desaturase + Transcription factor IIA, alpha/beta subunit + Protein of unknown function DUF4505 + Diphthamide synthase domain + Uncharacterised protein family UPF0145 + Protein of unknown function DUF2452 + Bacteriophage phiNM3, A0EWY4 + Sodium:dicarboxylate symporter, conserved site + Phage tail collar domain + CCR4-NOT transcription complex subunit 1, CAF1-binding domain + Knr4/Smi1-like domain + Vacuolar protein sorting-associated protein 8, central domain + Ribosomal protein S19e + Translocation protein Sec62 + Translocation protein Sec66 + Autophagy-related, C-terminal + Chalcone isomerase + DTXR-type HTH domain + Symplekin C-terminal + Pyrimidine nucleoside phosphorylase, C-terminal + Peptidase M10A + PdxT/SNO family, conserved site + TonB-dependent siderophore receptor + Bacterial TonB-dependent receptor + Protein of unknown function DUF3131 + Protein of unknown function DUF604 + Succinate semialdehyde dehydrogenase + Citrate synthase, eukaryotic-type + N-acetylneuraminic acid synthase, N-terminal + Transmembrane adaptor Erv26 + Domain of unknown function DUF4472 + Domain of unknown function DUF1619 + Cornichon + Lipase/vitellogenin + Ribosomal RNA-processing protein 14/surfeit locus protein 6, C-terminal domain + Domain of unknown function DUF4440 + NUC194 + Helix-turn-helix, HxlR type + Protein of unknown function DUF1168 + Microsomal signal peptidase 12kDa subunit + Ribosomal protein L30, conserved site + KRR1 interacting protein 1 + Phospholipase C/P1 nuclease domain + Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB) domain + General secretion pathway protein K + Beta-glucan synthesis-associated, SKN1 + Isochorismatase + MIF4G-like, type 1 + MIF4G-like, type 2 + Protein of unknown function DUF3775 + Flagellar motor stator, MotA + Glutamate racemase + Protein of unknown function DUF2130 + Protein of unknown function DUF2380 + Uncharacterised domain UPF0547 + Autophagy-related protein 13 + Knottin, scorpion toxin-like + Nuclease associated modular domain 3 + Domain of unknown function DUF4140 + DML1/Misato, tubulin domain + Fructosamine/Ketosamine-3-kinase + 4-hydroxybenzoate 3-monooxygenase + ATP-dependent Clp protease ATP-binding subunit ClpA + Uncharacterised protein family AroM + Occludin homology domain + GPCR, family 2, secretin-like + RNA polymerase sigma factor 70, ECF, conserved site + Delta tubulin + Asparagine synthase, glutamine-hydrolyzing + Eukaryotic translation initiation factor 3 subunit G, N-terminal + Streptogrisin prodomain + RNA polymerases, subunit N, zinc binding site + Splicing factor 1, helix-hairpin domain + UNC-50 + SUF system FeS cluster assembly regulator + Radial spoke 3 + NnrS + Arylsulfotransferase, C-terminal + Ecotin, C-terminal + DBINO domain + Lipoxygenase, conserved site + Tol-Pal system beta propeller repeat-containing protein, TolB + Thiamine-monophosphate kinase + Thiamin pyrophosphokinase + SNF5/SMARCB1/INI1 + Biopolymer transport, TolR + Alpha/beta-hydrolase, catalytic domain + Protein of unknown function DUF2451, C-terminal + Protein kinase A anchor protein, nuclear localisation signal domain + Zinc finger protein DZIP1, N-terminal + Heme-NO binding + Purine nucleoside permease + DeoR C-terminal sensor domain + RIO kinase, conserved site + PDZ-like domain + ODR-4-like + Domain of unknown function DUF1338 + Ribosome control protein 1 + Cell division cycle protein 123 + Anthranilate synthase component I, PabB-like + Protein of unknown function DUF1849 + Glycoside hydrolase, family 77 + Protein of unknown function DUF4539 + Uncharacterised domain, YlbE + Flagellar basal-body rod FlgF + Flagellar basal-body rod FlgG + Metallophosphoesterase, DNA ligase-associated + Histone RNA hairpin-binding protein, RNA-binding domain + Conserved oligomeric Golgi complex subunit 8 + Protein of unknown function DUF5309 + MD-2-related lipid-recognition domain + Ribosomal protein L6, chloroplast + PA14 domain + Coiled-coil domain-containing protein 24 + Alkyl hydroperoxide reductase subunit C + Ribosomal protein L37, mitochondrial + Cdc37, Hsp90 binding + Biotin-independent malonate decarboxylase, beta subunit + TFIIH p62 subunit, N-terminal + YAP-binding/ALF4/Glomulin + Photosystem II PsbN + Glycosyl hydrolase 94 + Clusterin-associated protein-1 + Rod shape-determining protein RodA + Chitin binding domain + Glycoside hydrolase, family 32, active site + Aldose 1-epimerase, conserved site + Phosphomannose isomerase, type I, conserved site + UPF0255 family + Photosystem II PsbU, oxygen evolving complex + TATA element modulatory factor 1 TATA binding + Lipocalin family conserved site + Beta-carotene 15,15'-monooxygenase, Brp/Blh family + Protein DPCD + Eukaryotic rRNA processing + Excalibur calcium-binding domain + Protein of unknown function DUF1823 + NolW-like + Meiotic nuclear division protein 1 + Phosphoadenosine phosphosulphate/adenosine 5'-phosphosulphate reductase + LCCL domain + Phage shock protein B + Glutamine synthetase class-I, adenylation site + Ribosomal protein L21e + Alpha carbonic anhydrase + ATPase, vacuolar ER assembly factor, Vma12 + Patatin-related protein + Transposase IS204/IS1001/IS1096/IS1165, zinc-finger + T-complex protein 1, epsilon subunit + T-complex protein 1, gamma subunit + T-complex protein 1, beta subunit + T-complex protein 1, delta subunit + T-complex protein 1, alpha subunit + Cytochrome b-c1 complex subunit 7 + Transcription initiation factor IID, subunit 13 + TATA-box binding protein + 7Fe ferredoxin + Glycosyl transferase, family 35 + Photosystem I PsaG/PsaK protein + Ribosomal RNA small subunit methyltransferase J + Uridine kinase-like + Coatomer, alpha subunit, C-terminal + Cysteine desulfurase IscS + Protein of unknown function DUF1289 + Protein of unknown function DUF1294 + Putative rRNA methylase + Glycosyl hydrolase family 95, N-terminal domain + Protein Thf1 + Photosystem I PsaK, reaction centre + Photosystem I protein PsaC + DNA ligase D, polymerase domain + Rad21/Rec8-like protein, N-terminal + DNA ligase D + Popeye protein + YppE-like domain + Nucleoporin, NSP1-like, C-terminal + Calcium permeable stress-gated cation channel 1, N-terminal transmembrane domain + N-acetylglucosaminyltransferase, MurG + CRISPR-associated protein Cas1 + FGGY carbohydrate kinase, pentulose kinase + Carbohydrate kinase, thermoresistant glucokinase + Glutamate synthase, NADH/NADPH, small subunit 2 + Flagellar FlaF + Glutathionylspermidine synthase, pre-ATP-grasp-like domain + Type IV secretion system, VirB10 / TraB / TrbI + MRN complex-interacting protein + Starter unit:ACP transacylase + Protein FAM72 + Uncharacterised conserved protein UCP028704, OpgC + Putative phosphate transport regulator + Protein of unknown function DUF2478 + Anamorsin + Pre-rRNA-processing protein TSR2 + Colon cancer-associated Mic1-like + Protein of unknown function DUF1269, membrane associated + Protein of unknown function DUF2093 + Domain of unknown function DUF2126 + Protein of unknown function DUF3734 + Protein of unknown function DUF2838 + Domain of unknown function DUF3449 + Sensor N-terminal transmembrane domain + Phosphopentomutase DeoB cap domain + Translation initiation factor 2, alpha subunit, middle domain + Translation initiation factor 2, alpha subunit, C-terminal + Sodium:neurotransmitter symporter + Branched-chain amino acid transport, AzlD + Pre-mRNA-splicing factor SPF27 + EcoEI R protein C-terminal domain + Mitochondrial inner membrane protein Mitofilin + Transcription factor IIIC, subunit 5 + Polycomb protein, VEFS-Box + Cactin, C-terminal + Cullin, conserved site + Phosphotransferase/anion transporter + VASt domain + Autophagy-related protein 5 + DNA primase large subunit, eukaryotic/archaeal + SlyX + Vps53-like, N-terminal + DNA modification/repair radical SAM protein, putative + Peptidase S59, nucleoporin + Ribosomal protein S6e + S1/P1 nuclease + Domain of unknown function DUF382 + MYND-like zinc finger, mRNA-binding + Ribosomal RNA small subunit methyltransferase F, N-terminal + Protein TIC110, chloroplastic + Cdc37, N-terminal domain + Precorrin-2 C(20)-methyltransferase domain + Ribonuclease III + Ubiquitin-activating enzyme E1, conserved site + DNA-binding, RecF, conserved site + Zinc-binding domain + Muconolactone isomerase domain + 1,2-phenylacetyl-CoA epoxidase, subunit A/C + Chromosome transmission fidelity protein 8 + Uncharacterised conserved protein UCP033924 + RIO2 kinase winged helix domain, N-terminal + Death-like domain of Spt6 + Domain of unknown function DUF2231, transmembrane + Galactosyltransferase, N-terminal + Possible tRNA binding domain + 2-isopropylmalate synthase + Sulphate ABC transporter permease protein 2 + Histone acetyltransferase ELP3 + Translation elongation factor, selenocysteine-specific + L-seryl-tRNA(Sec) selenium transferase + Haemolysin A /rRNA methyltransferase TlyA + Helicase XPB/Ssl2 + Poly-beta-hydroxybutyrate polymerase N-terminal + Mitotic-spindle organizing protein 1 + Polyadenylate binding protein, human types 1, 2, 3, 4 + Protein of unknown function DUF4345 + Glutaminase + Probable phospholipid ABC transporter-binding protein MlaD + Peptidase M24A, methionine aminopeptidase, subfamily 2 + Ribosomal biogenesis regulatory protein + Conserved hypothetical protein CHP02594 + CRISPR-associated protein Cas5, N-terminal + Colicin immunity protein/pyocin immunity protein + Photosystem II PsbZ, reaction centre + NADH:ubiquinone oxidoreductase, subunit G + ATP binding protein MinD, bacterial-type + ATP-dependent helicase HrpB + Copine + Protein of unknown function DUF543 + Coenzyme F420 hydrogenase/dehydrogenase beta subunit, N-terminal + Mss4 + N6 adenine-specific DNA methyltransferase, D21 class + Pre-mRNA-splicing factor Cwf15/Cwc15 + PT repeat + Dolichol phosphate-mannose biosynthesis regulatory + Steroid receptor RNA activator-protein/coat protein complex II, Sec31 + Signal recognition particle, SRP14 subunit + tRNA wybutosine-synthesis + Adenylate cyclase-associated CAP, C-terminal + Protein of unknown function DUF2076 + Transferase 1, rSAM/selenodomain-associated + Coenzyme PQQ synthesis D + Oxygen-evolving enhancer protein 3 + NADH dehydrogenase subunit 5, C-terminal + DNA-directed RNA polymerase, helix hairpin domain + Protein of unknown function DUF1674 + Putative deacetylase LmbE-like domain + Lycopene cyclase + Domain of unknown function DUF1737 + DNA methyltransferase 1-associated 1 + Vanillyl-alcohol oxidase/Cytokinin dehydrogenase C-terminal domain + FR47-like + DNA polymerase delta, subunit 4 + Mitochondrial glycoprotein + Opine dehydrogenase + Malonyl-CoA decarboxylase, N-terminal + Nrap protein, domain 6 + Conserved hypothetical protein CHP03083, actinobacterial-type + Protein of unknown function DUF727 + PQQ-dependent dehydrogenase, methanol/ethanol family + Conserved hypothetical protein CHP03084 + Ribosomal protein S36, mitochondrial + Bromodomain associated domain + Glycosyltransferase 2-like, prokaryotic type + Fas apoptotic inhibitory molecule 1 + DNA replication complex GINS protein SLD5, C-terminal + Glycosyl hydrolase family 63, N-terminal + Putative L,D-transpeptidase catalytic domain + Gentisate 1,2-dioxygenase + dCTP deaminase + Centromere protein CENP-B, C-terminal domain + Proteinase inhibitor I11, ecotin domain + Ribosomal protein L44e + Ubiquinol-cytochrome C reductase hinge domain + Homospermidine synthase-like, domain + Vacuolar protein sorting-associated protein Ist1 + Luc7-related + Glucanosyltransferase + NADH-ubiquinone oxidoreductase, 21kDa subunit, N-terminal + Histone-binding protein RBBP4, N-terminal + Anaphase-promoting complex subunit 5 + 1-acyl-sn-glycerol-3-phosphate acyltransferase + Diphthine synthase + BCP1 family + Ribosomal protein L5 eukaryotic/L18 archaeal, C-terminal + Oxygen-independent coproporphyrinogen III oxidase HemN + Protein kish + Putative methionine gamma-lyase + Uncharacterised protein family, methyltransferase, Williams-Beuren syndrome + Protein of unknown function DUF3326 + Cleavage and polyadenylation specificity factor 2, C-terminal + Mannosyltransferase, DXD + Methyl-accepting chemotaxis protein (MCP) signalling domain + DNA topoisomerase VI, subunit A + Ribosomal protein L36e + Ribosomal protein S27a + Lysine-tRNA ligase + Transcriptional coactivator Hfi1/Transcriptional adapter 1 + SGF29 tudor-like domain + Hepatocellular carcinoma-associated antigen 59 + Ubiquinone biosynthesis hydroxylase UbiH/COQ6 + HflK + Mak16 protein + Nitric oxide synthase-interacting protein, zinc-finger + Protein of unknown function DUF5076 + Nitrate reductase, alpha subunit, N-terminal + Putative Actinobacterial Holin-X, holin superfamily III + FACT complex subunit Spt16p/Cdc68p + Histone deacetylation protein Rxt3 + U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein + E3 ubiquitin ligase, BRE1 + CFAP91 domain + Type IV secretion system, VirB3 / TrbD / AvhB + Uncharacterised protein family UPF0114, bacteria + DNA gyrase, subunit B + Initiation factor 2B alpha/beta/delta + Transmembrane protein 18 + Frataxin conserved site + Glutathione-dependent formaldehyde-activating enzyme + Phosphotransferase system, EIIB component, type 2/3 + Gemin6 + Beta-catenin-interacting ICAT + Type III secretion system inner membrane R protein + Ferredoxin-dependent bilin reductase + Kinetochore protein Nuf2 + Cell division protein FtsQ/DivIB + Mediator complex, subunit Med7 + SMN complex, gem-associated protein 7 + Gluconate 2-dehydrogenase subunit 3 + Protein of unknown function DUF2039 + Protein of unknown function DUF2181 + Smg8/Smg9 + BAR domain + Domain of unknown function DUF1741 + siRNA-mediated silencing protein NRDE-2 + Cytochrome B561-related + Prp31 C-terminal + Peptidase M32, carboxypeptidase Taq + SDA1 domain + Protein of unknown function DUF726 + SH3-binding 5 + Glutamine synthetase, type III + Carbon catabolite-derepressing protein kinase, ubiquitin-associated domain + Protein of unknown function DUF1769 + A1 cistron-splicing factor, AAR2 + Protein of unknown function DUF541 + Ribosomal protein PSRP-3/Ycf65 + Histidinol-phosphate phosphatase + P-type ATPase, subfamily V + Kinase phosphorylation domain + RNA polymerase sigma factor 54, DNA-binding + Domain of unknown function DUF4709 + Ndc10, domain 2 + THO complex subunit 2, N-terminal domain + Putative 4-mercaptohistidine N1-methyltranferase, OvoA C-terminal domain + Flagellar hook protein FlgE + TUP1-like enhancer of split + Lipid A biosynthesis, N-terminal + Predicted HAD-superfamily phosphatase, subfamily IA/Epoxide hydrolase, N-terminal + DNA recombination/repair protein Rad51 + Usg-like + CAS/CSE, C-terminal + STELLO-like + Transcription initiation factor IIF, alpha subunit + Spindle assembly checkpoint component Mad1 + Tyrosine/nicotianamine aminotransferase + Fumarylacetoacetase + ATP synthase, F0 complex, subunit C, bacterial/chloroplast + Splicing factor 3A subunit 1 + RAVE complex protein Rav1 C-terminal + A-kinase anchor protein 28kDa + TUG ubiquitin-like domain + Copper amine oxidase, C-terminal + DNA-directed RNA polymerase I subunit RPA2, domain 4 + Autophagy-related protein 101 + Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6, conserved site + Neprosin + MEMO1 family + FAM194 family + Ribosomal protein L7A/L8 + ERCC1/RAD10/SWI10 family + Transcription-repair coupling factor + rRNA small subunit methyltransferase B + Protoporphyrinogen oxidase + Ragulator complex protein LAMTOR5 + PAN2 domain + RNA 3'-terminal phosphate cyclase, insert domain + Domain of unknown function DUF3376 + Cyclin-dependent kinase, regulatory subunit + RNA polymerase, subunit H/Rpb5 C-terminal + MCP methyltransferase, CheR-type + Homologous-pairing protein 2 + Ecd family + NIF system FeS cluster assembly, NifU, N-terminal + XAP5 protein + Creatininase/formamide hydrolase + SHQ1 protein + DYW domain + DNA-directed RNA polymerase, 14-18kDa subunit, conserved site + Nop2p + Oxygen-dependent choline dehydrogenase + Glycogen debranching enzyme, C-terminal + Equilibrative nucleoside transporter + Transcription regulator LexA + Mevalonate kinase + Threonine dehydratase, catabolic + Transcription initiation factor TFIID, 23-30kDa subunit + Ribosomal protein L14e domain + ANTAR domain + NF-kappa-B-activating protein + Arc-like DNA binding domain + Putative nucleotidyltransferase + Solute carrier family 35 member SLC35F1/F2/F6 + Protein of unknown function DUF2177, membrane + Ribose 5-phosphate isomerase B + RNA polymerase sigma factor RpoD, C-terminal + Mannitol dehydrogenase, conserved site + F420-dependent oxidoreductase-predicted, MSMEG2249 + PQQ-dependent catabolism-associated CXXCW motif + Gamma-secretase aspartyl protease complex, presenilin enhancer-2 subunit + DNA polymerase III delta, N-terminal + Myeloid leukemia factor + ZinT domain + Coenzyme A transferase active site + Coiled-coil domain of unkwon function DUF2037 + Uncharacterised protein family FPL + Vesicle transport protein, Use1 + DDRGK domain containing protein + Protein of unknown function DUF2046 + Ribosome-assembly protein 3 + Protein of unknown function DUF3037 + Peptidase S1A, chymotrypsin family + Pumilio RNA-binding repeat + Muconolactone delta-isomerase + Cytochrome c oxidase, monohaem subunit/FixO + Polyribonucleotide nucleotidyltransferase + Mad3/Bub1 homology region 1 + Mycothiol-dependent maleylpyruvate isomerase, metal-binding domain + LURP1-related protein domain + Protein of unknown function DUF423 + Serine-threonine protein phosphatase, N-terminal + Uncharacterised protein family UPF0311 + FkbH domain + MoaD, archaeal-type + Enolase-phosphatase E1 + Cobinamide kinase/cobinamide phosphate guanyltransferase + Protein of unknown function DUF1428 + Glycosylphosphatidylinositol-mannosyltransferase I, PIG-X/PBN1 + PPP domain + Clp1, N-terminal beta-sandwich domain + RNA polymerase III, subunit Rpc25 + Dynamin, GTPase region, conserved site + Dynein light chain, type 1/2, conserved site + Domain of unknown function DUF3598 + Cilia- and flagella-associated protein 206 + RIB43A + Seipin family + Lipase maturation factor + Domain of unknown function DUF1624 + Folate receptor-like + CagE, TrbE, VirB component of type IV transporter system, central domain + UDP-galactopyranose mutase + Mediator complex, subunit Med31 + Acetate/propionate kinase + Transcriptional regulator Spx/MgsR + Cobalamin (vitamin B12) biosynthesis CobF, precorrin-6A synthase + DNA-3-methyladenine glycosylase I + TFIIH C1-like domain + Helicase HerA-like C-terminal + Transcription factor TFIIH subunit p52/Tfb2 + Protein of unknown function DUF3297 + THO complex, subunitTHOC2, N-terminal + DinB-like domain + SUZ domain + Ribosomal protein L27e + DNA topoisomerase I + Ribonucleotide reductase small subunit, acitve site + Domain of unknown function DUF659 + Glutamate synthase, NADH/NADPH, small subunit 1 + Interleukin-10, additional helical + Protein of unknown function DUF2854 + Pre-mRNA-splicing factor 19 + PLD-like domain + Tyrosine kinase, G-rich domain + Putative HupE/UreJ protein + Protein of unknown function DUF2852 + Peroxisome membrane protein, Pex16 + Ribosomal protein L31e, conserved site + Ribosome-binding factor A, conserved site + ASPIC/UnbV + Non-structural maintenance of chromosomes element 1 + UMP-CMP kinase + UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase + A/G-specific adenine glycosylase MutY + Uracil phosphoribosyl transferase + Putative glycolipid-binding protein + Chitin-binding, type 1, conserved site + Coproporphyrinogen III oxidase, conserved site + Phosphoribulokinase + Apyrase + Taxilin family + Dual specificity/tyrosine protein phosphatase, N-terminal + Plasmid encoded RepA protein + DNA-directed RNA polymerase III subunit Rpc5 + Shikimate kinase, conserved site + YnbE-like lipoprotein + Guanine nucleotide exchange factor, Ric8 + DNA topoisomerase VI, subunit B, transducer + CCR4-NOT transcription complex subunit 11 + Ribosomal protein Rsm22-like + rRNA-processing protein Efg1 + Iron hydrogenase, large subunit, C-terminal + Muniscin C-terminal + Proline-rich protein PRCC + Histidine kinase CheA-like, homodimeric domain + Phytoene dehydrogenase, bacterial-type, conserved site + Protein of unknown function DUF4112 + Glycoside hydrolase, family 4 + GDSL lipase/esterase + 3Fe-4S ferredoxin + Domain of unknown function DUF2786 + Domain of unknown function DUF5107 + Protein of unknown function DUF4267 + DnaJ-like protein C11, C-terminal + Rit1, DUSP-like domain + 26S proteasome regulatory subunit, C-terminal + Peptidoglycan binding domain + Emopamil-binding protein + Uncharacterised protein family UPF0250 + Centrosomal CEP44 domain + Casein Kinase 2 substrate + Uncharacterised protein family UPF0283 + Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain + PROCT domain + Protein of unknown function DUF1223 + Glycosyl hydrolase family 59, central domain + Cobalamin biosynthesis, precorrin-6Y methyltransferase, CbiT subunit + Type II secretion system protein J + General secretion pathway protein G + Type II secretion system protein I + Protein Pet100 + T-complex protein 10, C-terminal domain + ATPase, V1 complex, subunit H, C-terminal + Ubiquitin-like protein Atg12 + + Bacteria + Proteobacteria + Alphaproteobacteria + Rhodobacterales + Rhodobacteraceae + + + Bacteria + Proteobacteria + Alphaproteobacteria + Rhodobacterales + Rhodobacteraceae + Paracoccus + + + Bacteria + Proteobacteria + Alphaproteobacteria + Sphingomonadales + Sphingomonadaceae + Sphingopyxis + + + Chloroplast + Chrysochromulina_sp._CCMP291 + + + Eukaryota + Prymnesiales + Chrysochromulinaceae + Chrysochromulina + + + Bacteria + Proteobacteria + Alphaproteobacteria + Rhodobacterales + Rhodobacteraceae + Paracoccus + + + Bacteria + Proteobacteria + Alphaproteobacteria + Rhodobacterales + Rhodobacteraceae + Paracoccus + Paracoccus_sanguinis + + + Bacteria + Proteobacteria + Alphaproteobacteria + Rhodospirillales + Acetobacteraceae + Roseomonas + + + Bacteria + Proteobacteria + Alphaproteobacteria + Sphingomonadales + Sphingomonadaceae + + + Bacteria + Proteobacteria + Alphaproteobacteria + Sphingomonadales + Sphingomonadaceae + Novosphingobium + + + Chloroplast + Chrysochromulina_sp._CCMP291 + + + Eukaryota + Isochrysidales + Noelaerhabdaceae + Emiliania + + + Eukaryota + Prymnesiales + Chrysochromulinaceae + Chrysochromulina + Chrysochromulina_sp._CCMP291 + + + Eukaryota + Prymnesiales + Prymnesiaceae + Prymnesium + Prymnesium_parvum + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + 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+ + + Archaea + Euryarchaeota + Methanomicrobia + Methanomicrobiales + + + Archaea + Euryarchaeota + Methanomicrobia + Methanomicrobiales + Methanomicrobiaceae + + + Archaea + Euryarchaeota + Methanomicrobia + Methanomicrobiales + Methanomicrobiaceae + Methanogenium + Methanogenium_cariaci + + + Archaea + Euryarchaeota + Methanomicrobia + Methanosarcinales + + + Archaea + Euryarchaeota + Methanomicrobia + Methanosarcinales + Methanosaetaceae + + + Archaea + Thaumarchaeota + Nitrososphaeria + Nitrososphaerales + + + Archaea + Thaumarchaeota + Nitrososphaeria + Nitrososphaerales + Nitrososphaeraceae + + + Bacteria + methanotrophic_endosymbiont_of_Bathymodiolus_azoricus_(Menez_Gwen) + + + Bacteria + Candidatus_Aegiribacteria + + + Bacteria + Acidobacteria + + + Bacteria + Actinobacteria + Acidimicrobiia + Acidimicrobiales + Acidimicrobiaceae + + + Bacteria + Actinobacteria + Acidimicrobiia + Acidimicrobiales + Acidimicrobiaceae + Ilumatobacter + Ilumatobacter_coccineus + + + Bacteria + Actinobacteria + Actinobacteria + Corynebacteriales + Nocardiaceae + Rhodococcus + + + Bacteria + Actinobacteria + Coriobacteriia + Coriobacteriales + + + Bacteria + Actinobacteria + Coriobacteriia + Coriobacteriales + Coriobacteriaceae + + + Bacteria + Actinobacteria + Coriobacteriia + Coriobacteriales + Coriobacteriaceae + Coriobacteriaceae_bacterium_EMTCatB1 + + + Bacteria + Actinobacteria + Thermoleophilia + Solirubrobacterales + + + Bacteria + Bacteroidetes + + + Bacteria + Bacteroidetes + Bacteroidia + + + Bacteria + Bacteroidetes + Bacteroidia + Bacteroidales + + + Bacteria + Bacteroidetes + Bacteroidia + Marinilabiliales + Prolixibacteraceae + Mariniphaga + + + Bacteria + Bacteroidetes + Flavobacteriia + + + Bacteria + Bacteroidetes + Flavobacteriia + Flavobacteriales + + + Bacteria + Bacteroidetes + Flavobacteriia + Flavobacteriales + Flavobacteriaceae + + + Bacteria + Bacteroidetes + Flavobacteriia + Flavobacteriales + Flavobacteriaceae + Lutibacter + + + Bacteria + Bacteroidetes + Flavobacteriia + Flavobacteriales + Flavobacteriaceae + Maribacter + + + Bacteria + Bacteroidetes + Flavobacteriia + Flavobacteriales + Flavobacteriaceae + Muricauda + + + Bacteria + Bacteroidetes + Flavobacteriia + Flavobacteriales + Flavobacteriaceae + Muricauda + Muricauda_zhangzhouensis + + + Bacteria + Caldiserica + Caldisericia + Caldisericales + + + Bacteria + Candidatus_Aerophobetes + Aerophobetes_bacterium_AeroCD12-1 + + + Bacteria + Candidatus_Amesbacteria + + + Bacteria + Candidatus_Aminicenantes + + + Bacteria + Candidatus_Atribacteria + + + Bacteria + Candidatus_Colwellbacteria + + + Bacteria + Candidatus_Doudnabacteria + + + Bacteria + Candidatus_Falkowbacteria + + + Bacteria + Candidatus_Gottesmanbacteria + + + Bacteria + Candidatus_Hydrogenedentes + + + Bacteria + Candidatus_Marinimicrobia + + + Bacteria + Candidatus_Marinimicrobia + Marinimicrobia_bacterium_TCS57 + + + Bacteria + Candidatus_Microgenomates + + + Bacteria + Candidatus_Pacebacteria + + + Bacteria + Candidatus_Schekmanbacteria + + + Bacteria + Candidatus_Wildermuthbacteria + + + Bacteria + Candidatus_Woesebacteria + + + Bacteria + Chloroflexi + + + Bacteria + Chloroflexi + Anaerolineae + Anaerolineales + + + Bacteria + Chloroflexi + Anaerolineae + Anaerolineales + Anaerolineaceae + + + Bacteria + Chloroflexi + Caldilineae + Caldilineales + + + Bacteria + Chloroflexi + Caldilineae + Caldilineales + Caldilineaceae + + + Bacteria + Chloroflexi + Dehalococcoidia + + + Bacteria + Chloroflexi + Dehalococcoidia + Dehalococcoidia_bacterium_SCGC_AB-539-J10 + + + Bacteria + Cyanobacteria + Synechococcales + + + Bacteria + Cyanobacteria + Synechococcales + Synechococcaceae + Synechococcus + + + Bacteria + Deferribacteres + Deferribacteres + Deferribacterales + + + Bacteria + Firmicutes + Bacilli + Bacillales + + + Bacteria + Firmicutes + Bacilli + Bacillales + Bacillaceae + + + Bacteria + Firmicutes + Bacilli + Bacillales + Bacillaceae + Bacillus + + + Bacteria + Firmicutes + Bacilli + Bacillales + Planococcaceae + + + Bacteria + Firmicutes + Clostridia + Clostridiales + + + Bacteria + Firmicutes + Clostridia + Clostridiales + Clostridiaceae + + + Bacteria + Firmicutes + Clostridia + Clostridiales + Clostridiaceae + Clostridium + + + Bacteria + Firmicutes + Clostridia + Clostridiales + Peptostreptococcaceae + + + Bacteria + Firmicutes + Erysipelotrichia + Erysipelotrichales + + + Bacteria + Lentisphaerae + + + Bacteria + Planctomycetes + + + Bacteria + Planctomycetes + Phycisphaerae + Phycisphaerales + + + Bacteria + Planctomycetes + Planctomycetia + Planctomycetales + + + Bacteria + Proteobacteria + Alphaproteobacteria + Rhizobiales + + + Bacteria + Proteobacteria + Alphaproteobacteria + Rhizobiales + Methyloceanibacter + + + Bacteria + Proteobacteria + Alphaproteobacteria + Rhizobiales + Hyphomicrobiaceae + + + Bacteria + Proteobacteria + Alphaproteobacteria + Rhodobacterales + + + Bacteria + Proteobacteria + Alphaproteobacteria + Rhodobacterales + Rhodobacteraceae + + + Bacteria + Proteobacteria + Alphaproteobacteria + Sphingomonadales + Erythrobacteraceae + + + Bacteria + Proteobacteria + Alphaproteobacteria + Sphingomonadales + Erythrobacteraceae + Altererythrobacter + + + Bacteria + Proteobacteria + Alphaproteobacteria + Sphingomonadales + Erythrobacteraceae + Erythrobacter + + + Bacteria + Proteobacteria + Alphaproteobacteria + Sphingomonadales + Erythrobacteraceae + Erythrobacter + Erythrobacter_marinus + + + Bacteria + Proteobacteria + Deltaproteobacteria + + + Bacteria + Proteobacteria + Deltaproteobacteria + Desulfarculales + + + Bacteria + Proteobacteria + Deltaproteobacteria + Desulfarculales + Desulfarculaceae + + + Bacteria + Proteobacteria + Deltaproteobacteria + Desulfobacterales + + + Bacteria + Proteobacteria + Deltaproteobacteria + Desulfobacterales + Desulfobacteraceae + + + Bacteria + Proteobacteria + Deltaproteobacteria + Desulfovibrionales + + + Bacteria + Proteobacteria + Deltaproteobacteria + Desulfovibrionales + Desulfovibrionaceae + Halodesulfovibrio + Halodesulfovibrio_spirochaetisodalis + + + Bacteria + Proteobacteria + Deltaproteobacteria + Desulfuromonadales + Desulfuromonadaceae + + + Bacteria + Proteobacteria + Deltaproteobacteria + Desulfuromonadales + Geobacteraceae + + + Bacteria + Proteobacteria + Deltaproteobacteria + Syntrophobacterales + + + Bacteria + Proteobacteria + Deltaproteobacteria + Syntrophobacterales + Syntrophaceae + + + Bacteria + Proteobacteria + Epsilonproteobacteria + Sulfurovum + + + Bacteria + Proteobacteria + Epsilonproteobacteria + Campylobacterales + + + Bacteria + Proteobacteria + Epsilonproteobacteria + Campylobacterales + Campylobacteraceae + Arcobacter + Arcobacter_nitrofigilis + + + Bacteria + Proteobacteria + Epsilonproteobacteria + Campylobacterales + Helicobacteraceae + + + Bacteria + Proteobacteria + Gammaproteobacteria + + + Bacteria + Proteobacteria + Gammaproteobacteria + Alteromonadales + + + Bacteria + Proteobacteria + Gammaproteobacteria + Alteromonadales + Alteromonadaceae + Marinobacter + + + Bacteria + Proteobacteria + Gammaproteobacteria + Alteromonadales + Idiomarinaceae + Idiomarina + + + Bacteria + Proteobacteria + Gammaproteobacteria + Alteromonadales + Pseudoalteromonadaceae + Pseudoalteromonas + Pseudoalteromonas_sp._P1-11 + + + Bacteria + Proteobacteria + Gammaproteobacteria + Alteromonadales + Shewanellaceae + Shewanella + + + Bacteria + Proteobacteria + Gammaproteobacteria + Cellvibrionales + + + Bacteria + Proteobacteria + Gammaproteobacteria + Cellvibrionales + Porticoccaceae + + + Bacteria + Proteobacteria + Gammaproteobacteria + Cellvibrionales + Porticoccaceae + Porticoccus + + + Bacteria + Proteobacteria + Gammaproteobacteria + Oceanospirillales + Halomonadaceae + Halomonas + + + Bacteria + Proteobacteria + Gammaproteobacteria + Oceanospirillales + Halomonadaceae + Halomonas + Halomonas_sulfidaeris + + + Bacteria + Proteobacteria + Gammaproteobacteria + Oceanospirillales + Oceanospirillaceae + + + Bacteria + Proteobacteria + Gammaproteobacteria + Pseudomonadales + + + Bacteria + Proteobacteria + Gammaproteobacteria + Pseudomonadales + Moraxellaceae + Psychrobacter + + + Bacteria + Proteobacteria + Gammaproteobacteria + Thiotrichales + + + Bacteria + Proteobacteria + Gammaproteobacteria + Thiotrichales + Piscirickettsiaceae + Cycloclasticus + + + Bacteria + Proteobacteria + Gammaproteobacteria + Xanthomonadales + Xanthomonadaceae + Stenotrophomonas + + + Bacteria + Proteobacteria + Gammaproteobacteria + Xanthomonadales + Xanthomonadaceae + Stenotrophomonas + Stenotrophomonas_maltophilia + + + Bacteria + Proteobacteria + Oligoflexia + Bacteriovoracales + Halobacteriovoraceae + Halobacteriovorax + Halobacteriovorax_marinus + + + Bacteria + Spirochaetes + + + Bacteria + Spirochaetes + Spirochaetia + Spirochaetales + + + Bacteria + Tenericutes + + + Bacteria + Tenericutes + Mollicutes + Acholeplasmatales + Acholeplasmataceae + + + Bacteria + Verrucomicrobia + + + Eukaryota + Oligohymenophorea + + + Eukaryota + Spirotrichea + + + Eukaryota + Apicomplexa + Gregarinasina + Eugregarinorida + + + Eukaryota + Bacillariophyta + + + Eukaryota + Metazoa + + + Mitochondria + marine_metagenome + + Winged helix-turn-helix DNA-binding domain + Aldolase-type TIM barrel + ABC transporter-like + Rossmann-like alpha/beta/alpha sandwich fold + Immunoglobulin-like fold + Nucleotide-diphospho-sugar transferases + FAD/NAD(P)-binding domain + Tetratricopeptide-like helical domain + Pyridoxal phosphate-dependent transferase, subdomain 2 + Pyridoxal phosphate-dependent transferase, major region, subdomain 1 + 4Fe-4S ferredoxin, iron-sulphur binding, conserved site + ABC transporter, conserved site + Histidine kinase-like ATPase, C-terminal domain + Signal transduction response regulator, receiver domain + Ribonuclease H-like domain + 4Fe-4S ferredoxin-type, iron-sulphur binding domain + ABC transporter type 1, transmembrane domain MetI-like + Alpha/Beta hydrolase fold + Glycosyl transferase, family 1 + Glycosyltransferase 2-like + Radical SAM + Metallo-beta-lactamase + Alkaline phosphatase-like, alpha/beta/alpha + Integrase-like, catalytic domain + Glycosyltransferase subfamily 4-like, N-terminal domain + Galactose-binding domain-like + Class I glutamine amidotransferase-like + Short-chain dehydrogenase/reductase SDR + Pectin lyase fold + ABC transporter, FecCD/TroCD-like + Ribosomal protein S5 domain 2-type fold, subgroup + Integrase, catalytic domain + RmlC-like jelly roll fold + HAD-like domain + Signal transduction histidine kinase-related protein, C-terminal + DNA methylase, N-6 adenine-specific, conserved site + Thiolase-like + WD40/YVTN repeat-like-containing domain + AMP-dependent synthetase/ligase + PIN domain-like + DNA methylase N-4/N-6 + GNAT domain + ABC transporter, permease + Major facilitator superfamily + Metallo-dependent phosphatase-like + PAS domain + Integrase/recombinase, N-terminal + GAF domain-like + Beta-grasp domain + Helicase, C-terminal + Sulfatase, N-terminal + Signal transduction histidine kinase, dimerisation/phosphoacceptor domain + Amidohydrolase-related + ATPase, AAA-type, core + Methyltransferase type 11 + Metal-dependent hydrolase, composite domain + ATP-grasp fold, subdomain 1 + Aminotransferase, class I/classII + Oxidoreductase, N-terminal + Integrase, catalytic core + Small GTP-binding protein domain + TonB-dependent receptor, beta-barrel + Arc-type ribbon-helix-helix + NAD-dependent epimerase/dehydratase + Acyl-CoA dehydrogenase/oxidase, N-terminal + Ribokinase-like + Acyl-CoA dehydrogenase/oxidase C-terminal + RNA polymerase sigma-70 like domain + K homology domain-like, alpha/beta + RNA polymerase sigma-70 region 2 + Transposase, Tn5-like, core + Cro/C1-type helix-turn-helix domain + Tetratricopeptide repeat + 6-phosphogluconate dehydrogenase, domain 2 + Crotonase superfamily + Hexapeptide repeat + Six-bladed beta-propeller, TolB-like + DNA methylase, adenine-specific + CBS domain + Aminoacyl-tRNA synthetase, class Ia, anticodon-binding + GTP binding domain + Nucleophile aminohydrolases, N-terminal + Short-chain dehydrogenase/reductase, conserved site + HD domain + Solute-binding protein family 5 domain + Transcription factor, GTP-binding domain + Acyl-CoA oxidase/dehydrogenase, central domain + NAD(P)-binding domain + Restriction/modification DNA-methylase + Prokaryotic N-terminal methylation site + DEAD/DEAH box helicase domain + GGDEF domain + Nucleotidyl transferase domain + TRAP C4-dicarboxylate transport system permease DctM subunit + Helicase/UvrB, N-terminal + PIN domain + Acriflavin resistance protein + Succinyl-CoA synthetase-like + Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II + TTHA1013/TTHA0281-like + Flavoprotein-like domain + DegT/DnrJ/EryC1/StrS aminotransferase + Uroporphyrinogen decarboxylase (URO-D) + Xylose isomerase-like, TIM barrel domain + EamA domain + Tryptophan synthase beta subunit-like PLP-dependent enzyme + von Willebrand factor, type A + GAF domain + CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 + Carbohydrate kinase PfkB + Secretion system C-terminal sorting domain + Cobalamin (vitamin B12)-binding domain + Transposase, IS4-like + AMP-binding enzyme, C-terminal domain + AMP-binding, conserved site + Aminotransferase class-III + CoA-transferase family III domain + Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase + Aldehyde ferredoxin oxidoreductase, C-terminal + DHS-like NAD/FAD-binding domain + Polymerase, nucleotidyl transferase domain + Nitroreductase-like + Enolase C-terminal domain-like + Restriction endonuclease, type I, HsdS + Alcohol dehydrogenase, N-terminal + Transposase IS200-like + Aminoacyl-tRNA synthetase, class Ia + Integrase, SAM-like, N-terminal + Aminoacyl-tRNA synthetase, class I, conserved site + Leucine-binding protein domain + Aldehyde dehydrogenase domain + OmpR/PhoB-type DNA-binding domain + TonB-dependent receptor, plug domain + NUDIX hydrolase domain + Aminotransferase class V domain + CoA-transferase family III + Cytochrome c-like domain + Aldehyde dehydrogenase N-terminal domain + Phosphoribosyltransferase domain + Mur ligase, central + Calcineurin-like phosphoesterase domain, ApaH type + LysR, substrate-binding + Ferritin-related + Thiamine pyrophosphate enzyme, C-terminal TPP-binding + WD40-like Beta Propeller + Transcription regulator HTH, LysR + RNA-binding S4 domain + Alpha/beta hydrolase fold-1 + Glutamine amidotransferase + Alcohol dehydrogenase, C-terminal + Peptidase M20 + Molybdopterin oxidoreductase + tRNA (guanine-N1-)-methyltransferase, N-terminal + RNA polymerase sigma factor 70, region 4 type 2 + Aspartate/glutamate/uridylate kinase + AIR synthase-related protein, C-terminal domain + Nitroreductase + Oligopeptide/dipeptide ABC transporter, C-terminal + CoA-binding + Aldehyde ferredoxin oxidoreductase, N-terminal + DNA-binding HTH domain, TetR-type + FMN-binding split barrel + RNA polymerase sigma factor 54 interaction domain + Ribosomal protein L2 domain 2 + Carbon-nitrogen hydrolase + ABC transporter permease protein domain + Transcription regulator HTH, GntR + PurM-like, N-terminal domain + TRAP transporter solute receptor DctP/TeaA + TOPRIM domain + Radical SAM, alpha/beta horseshoe + Aldehyde ferredoxin oxidoreductase, domain 3 + NADP-dependent oxidoreductase domain + ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain + GIY-YIG nuclease superfamily + Thiolase, N-terminal + S1 domain + PLP-binding barrel + Crontonase, C-terminal + Transcription regulator LuxR, C-terminal + Glycosyl hydrolase, five-bladed beta-propellor domain + Aldehyde ferredoxin oxidoreductase, domain 2 + Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding + Transketolase-like, pyrimidine-binding domain + HAD hydrolase, subfamily IA + Peptidase M24 + DnaJ domain + PDZ domain + Pyrrolo-quinoline quinone repeat + Type II secretion system protein E + Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant + D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain + Anticodon-binding + FAD-binding, type 2, subdomain 1 + Twin-arginine translocation pathway, signal sequence, bacterial/archaeal + FAD dependent oxidoreductase + Cysteine-rich domain + Pyruvate/ketoisovalerate oxidoreductase, catalytic domain + Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) + Cobalamin (vitamin B12)-dependent enzyme, catalytic + ABC transporter type 1, transmembrane domain + Sugar isomerase (SIS) + Translation elongation factor EFTu-like, domain 2 + EF-Hand 1, calcium-binding site + Peptidase S8/S53 domain + Pyruvate carboxyltransferase + HDIG domain + Enolase N-terminal domain-like + Aminoacyl-tRNA synthetase, class II (D/K/N) + LysM domain + Acyl-CoA dehydrogenase, conserved site + Peptidase M20, dimerisation domain + PAS fold + Outer membrane protein/outer membrane enzyme PagP, beta-barrel + Pyridine nucleotide-disulphide oxidoreductase, class-II + Penicillin-binding protein, transpeptidase + Cupin 2, conserved barrel + DNA binding HTH domain, Fis-type + Transposase DDE domain + UvrD/AddA helicase, N-terminal + UspA + Peptidase M23 + DegV + UvrD-like DNA helicase, C-terminal + Thiolase, C-terminal + AAA domain + OmpA-like domain + Methylmalonyl-CoA mutase, alpha/beta chain, catalytic + MacB-like periplasmic core domain + Parallel beta-helix repeat-2 + Endonuclease/exonuclease/phosphatase + Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 + Trimethylamine methyltransferase + 23S rRNA-intervening sequence protein + Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal + Cytidyltransferase-like domain + Biotin/lipoyl attachment + CobQ/CobB/MinD/ParA nucleotide binding domain + Transketolase, C-terminal domain + Carbohydrate kinase, FGGY, N-terminal + Transposase IS3/IS911family + Rhodanese-like domain + FAD-dependent oxidoreductase 2, FAD binding domain + UDP-glucose/GDP-mannose dehydrogenase, N-terminal + RNA polymerase sigma-70 region 4 + Acetyl-CoA carboxylase + Tripartite ATP-independent periplasmic transporter, DctQ component + NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit + Succinyl-CoA synthetase-like, flavodoxin domain + RND efflux pump, membrane fusion protein, barrel-sandwich domain + Aspartate/ornithine carbamoyltransferase + Outer membrane efflux protein + OB-fold nucleic acid binding domain, AA-tRNA synthetase-type + PKD domain + FAD linked oxidase, N-terminal + PHP domain + Transcription regulator FadR/GntR, C-terminal + Periplasmic copper-binding protein NosD, beta helix domain + Toxin-antitoxin system, RelE/ParE toxin family + Mur ligase, C-terminal + HIT-like domain + Resolvase, N-terminal catalytic domain + Protein kinase domain + DNA binding HTH domain, AraC-type + Sodium/solute symporter + D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain + DNA methylase, N-4 cytosine-specific, conserved site + Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain + Oxidoreductase, C-terminal + DHBP synthase RibB-like alpha/beta domain + Elongation factor EFG, domain V-like + O-antigen ligase-related + NUDIX hydrolase, conserved site + Solute-binding family 1 + NiFe hydrogenase-like + Helix-turn-helix, base-excision DNA repair, C-terminal + Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains + RNA polymerase sigma-70 + Electron transfer flavoprotein, alpha/beta-subunit, N-terminal + EAL domain + 2Fe-2S ferredoxin-type iron-sulfur binding domain + ACT domain + Hexapeptide transferase, conserved site + Armadillo-like helical + Transmembrane protein TauE-like + Tr-type G domain, conserved site + Bacterial sugar transferase + Thioredoxin domain + Transposase, IS116/IS110/IS902 + Domain of unknown function DUF11 + MoaB/Mog domain + Carbohydrate kinase, FGGY, C-terminal + Peptidase S9, prolyl oligopeptidase, catalytic domain + Cyclic nucleotide-binding domain + ABC-2 type transporter + DHHA1 domain + Mechanosensitive ion channel MscS + Type II secretion system F domain + FAD/NAD-linked reductase, dimerisation domain + Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain + Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding + Sulfatase, conserved site + PAS fold-4 + GntR, C-terminal + Pseudouridine synthase, RsuA/RluB/C/D/E/F + DapA-like + RND efflux pump, membrane fusion protein + Aminoacyl-tRNA synthetase, class Ic + Tetrapyrrole methylase, subdomain 1 + Clp ATPase, C-terminal + Alcohol dehydrogenase, zinc-type, conserved site + Transposase InsH, N-terminal + Formyl transferase, N-terminal + Sigma-54 interaction domain, ATP-binding site 1 + Transcription regulator AsnC/Lrp, ligand binding domain + HTH ArsR-type DNA-binding domain + Transposase, IS111A/IS1328/IS1533, N-terminal + S-adenosyl-L-methionine-dependent methyltransferase + Molybdopterin dinucleotide-binding domain + Sigma-54 interaction domain, conserved site + Heat shock protein 70 family + SinI-like, DNA-binding domain + Fumarase/histidase, N-terminal + Soluble ligand binding domain + ParB/Sulfiredoxin + PNPase/RNase PH domain + Dihydroprymidine dehydrogenase domain II + Peptidase S24/S26A/S26B/S26C + Transketolase, N-terminal + Histidine phosphatase superfamily + UDP-glucose/GDP-mannose dehydrogenase, dimerisation + Amidohydrolase 3 + Tetrapyrrole methylase + Beta-ketoacyl synthase, N-terminal + 4Fe4S-binding SPASM domain + Polysaccharide biosynthesis protein + HicB-like antitoxin of toxin-antitoxin system + Band 7 domain + Fumarate lyase, N-terminal + Thioesterase domain + Solute-binding protein family 3/N-terminal domain of MltF + GHMP kinase, C-terminal domain + MobA-like NTP transferase + Nucleotidyl transferase AbiEii toxin, Type IV TA system + Enoyl-CoA hydratase/isomerase, conserved site + HEPN domain + HicA mRNA interferase family + ClpA/B family + Polysaccharide biosynthesis protein, C-terminal domain + PEP-utilising enzyme, mobile domain + Phospholipid/glycerol acyltransferase + Chaperonin Cpn60/TCP-1 family + Peptidase M50 + Glyoxalase/fosfomycin resistance/dioxygenase domain + Transposase, mutator type + Tetratricopeptide repeat 1 + Creatinase/Aminopeptidase P/Spt16, N-terminal + NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain + Uracil-DNA glycosylase-like + Enolpyruvate transferase domain + Branched-chain amino acid ATP-binding cassette transporter, C-terminal + Beta-lactamase-related + NADPH-dependent FMN reductase-like + UDP-glucose/GDP-mannose dehydrogenase, C-terminal + Glutamine amidotransferase type 2 domain + Histidine phosphatase superfamily, clade-1 + Nucleoside phosphorylase domain + Fido domain + HAMP domain + Aminotransferases, class-I, pyridoxal-phosphate-binding site + IstB-like ATP-binding protein + FldB/FldC dehydratase alpha/beta subunit + Sigma-54 interaction domain, ATP-binding site 2 + GroEL-like equatorial domain + Exonuclease, phage-type/RecB, C-terminal + Isoprenoid synthase domain + Transglutaminase-like + Phosphopantetheine binding ACP domain + Dinitrogenase iron-molybdenum cofactor biosynthesis + Methyltransferase domain + Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain + Fe-S cluster assembly domain + Amidase signature domain + NAD/GMP synthase + 3-hydroxyacyl-CoA dehydrogenase, NAD binding + Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain + Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding + Sugar transporter, conserved site + Cation/H+ exchanger + Oligopeptide transport permease C-like, N-terminal domain + Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain + ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain + Alpha-D-phosphohexomutase, alpha/beta/alpha domain I + Alcohol dehydrogenase, iron-type + Serine aminopeptidase, S33 + Aspartic peptidase domain + UDP-N-acetylglucosamine 2-epimerase domain + Asparagine synthase + Inosine triphosphate pyrophosphatase-like + Isopropylmalate dehydrogenase-like domain + Glutamine synthetase/guanido kinase, catalytic domain + Phospholipase D-like domain + P-type ATPase + Clp, N-terminal + Thioredoxin, conserved site + N6 adenine-specific DNA methyltransferase, N-terminal domain + Tetrapyrrole methylase, subdomain 2 + HSP20-like chaperone + 2Fe-2S ferredoxin, iron-sulphur binding site + Aconitase/3-isopropylmalate dehydratase, swivel + Pyruvate phosphate dikinase, PEP/pyruvate-binding + SpoVT-AbrB domain + Peptide chain release factor class I/class II + CDP-alcohol phosphatidyltransferase + HTH-like domain + AsnC-type HTH domain + Gcp-like domain + Pterin-binding domain + Cold-shock protein, DNA-binding + Periplasmic binding protein + Restriction modification methylase Eco57I + UbiA prenyltransferase family + Metalloenzyme + Methyl-viologen-reducing hydrogenase, delta subunit + Alanyl-tRNA synthetase, class IIc, N-terminal + Methylthiotransferase, N-terminal + N6 adenine-specific DNA methyltransferase, D21 class + UVR domain + LacI-type HTH domain + MerR-type HTH domain + Regulator of K+ conductance, N-terminal + Alanine racemase, N-terminal + Molybdopterin oxidoreductase, 4Fe-4S domain + Domain of unknown function DUF362 + PAS fold-3 + Peptidase S1C + Ribonucleotide reductase large subunit, C-terminal + Alanine racemase/group IV decarboxylase, C-terminal + NADH:flavin oxidoreductase/NADH oxidase, N-terminal + D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site + Peptidase M16, C-terminal + Lamin Tail Domain + NADH:ubiquinone oxidoreductase-like, 20kDa subunit + Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2 + HhH-GPD domain + Type II toxin-antitoxin system, antitoxin Phd/YefM + Universal stress protein A + Leucine-rich repeat domain, L domain-like + Metalloprotease TldD/PmbA + Cytidine and deoxycytidylate deaminase domain + Regulator of K+ conductance, C-terminal + Domain of unknown function DUF35, OB-fold, C-terminal + PEP-utilising enzyme, C-terminal + Exoribonuclease, phosphorolytic domain 1 + Alpha-D-phosphohexomutase, alpha/beta/alpha domain III + Chromosomal replication initiator, DnaA C-terminal + Alpha-D-phosphohexomutase, C-terminal + Chaperone DnaJ, C-terminal + Sulfatase-modifying factor enzyme + Schlafen, AAA domain + Carbohydrate/puine kinase, PfkB, conserved site + 3-hydroxyacyl-CoA dehydrogenase, C-terminal + Integration host factor (IHF)-like DNA-binding domain + Nitrogen regulatory protein PII/ATP phosphoribosyltransferase, C-terminal + Threonyl/alanyl tRNA synthetase, SAD + GHMP kinase N-terminal domain + Ferrous iron transporter FeoA domain + MarR-type HTH domain + Metallopeptidase, catalytic domain + Histidine biosynthesis + Peptide chain release factor + Dehydrogenase, E1 component + UDP-glucose/GDP-mannose dehydrogenase + Methionyl/Leucyl tRNA synthetase + Ferric-uptake regulator + tRNA/rRNA methyltransferase, SpoU type + FAD-linked oxidase, C-terminal + Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase + Domain of unknown function DUF4143 + Methyl-accepting chemotaxis protein (MCP) signalling domain + Peptidase M48 + Pyruvate:ferredoxin oxidoreductase, core domain II + Plasmid maintenance toxin/Cell growth inhibitor + Histone deacetylase domain + Bacterial DNA polymerase III, alpha subunit + TaqI-like C-terminal specificity domain + Heat shock protein 70, conserved site + NodB homology domain + Alpha-D-phosphohexomutase, alpha/beta/alpha domain II + Tail specific protease + ROK family + Domain of unknown function DUF35, rubredoxin-like zinc ribbon domain, N-terminal + Inorganic polyphosphate/ATP-NAD kinase, domain 1 + CAAX amino terminal protease + Aminotransferase class IV + Reverse transcriptase domain + FAD-linked oxidoreductase-like + Translation elongation factor EF1B/ribosomal protein S6 + DNA topoisomerase, type IIA, subunit A/C-terminal + Fumarate lyase family + Transposase, IS66 + Coenzyme A transferase family I + APOBEC/CMP deaminase, zinc-binding + Glycoside hydrolase-type carbohydrate-binding + Glutamine synthetase, catalytic domain + NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain + Endoribonuclease L-PSP/chorismate mutase-like + ATPase, BadF/BadG/BcrA/BcrD type + MaoC-like domain + Methylthiotransferase, conserved site + 2-oxoacid dehydrogenase acyltransferase, catalytic domain + K Homology domain, type 1 + Oxidoreductase FAD/NAD(P)-binding + SNF2-related, N-terminal domain + Nucleoside transporter/FeoB GTPase, Gate domain + Histone-like DNA-binding protein + Probable peptidoglycan glycosyltransferase FtsW/RodA + YrdC-like domain + Signal recognition particle, SRP54 subunit, GTPase domain + Pyruvate formate lyase domain + Methylglyoxal synthase-like domain + Mur ligase, N-terminal catalytic domain + DNA-binding recombinase domain + RadC-like JAB domain + Domain of unknown function DUF262 + Calcineurin-like phosphoesterase domain, lpxH type + Multi antimicrobial extrusion protein + Thioredoxin-like fold + Tubulin/FtsZ, GTPase domain + Translation elongation factor EFG/EF2, domain IV + Beta-ketoacyl synthase, C-terminal + Alpha-isopropylmalate/homocitrate synthase, conserved site + PPM-type phosphatase domain + NUDIX hydrolase + Phosphoglycolate phosphatase, domain 2 + Phenylalanyl-tRNA synthetase, B3/B4 + DNA helicase, DnaB-like, C-terminal + Dihydroxy-acid/6-phosphogluconate dehydratase + Alpha crystallin/Hsp20 domain + Peptidase S8, subtilisin-related + Protein-export membrane protein SecD/SecF, archaeal and bacterial + Polyprenyl synthetase + Glycosyl transferase, family 51 + FlgD Ig-like domain + Flavin reductase like domain + mRNA interferase PemK-like + Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain + ATP synthase subunit alpha-like domain + Polysaccharide pyruvyl transferase + Vanillyl-alcohol oxidase, C-terminal subdomain 2 + Peptidase M16, N-terminal + Rubrerythrin + Hemolysin-type calcium-binding conserved site + Metalloprotease TldD/PmbA, N-terminal domain + Exoribonuclease, phosphorolytic domain 2 + Cobalamin (vitamin B12)-binding module, cap domain + Transcription regulator PadR, N-terminal + Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35 + DNA topoisomerase, type IIA + Zinc finger, CHC2-type + 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III, C-terminal + Outer membrane protein, bacterial + Creatinase, N-terminal + Glycosyl hydrolase, family 13, catalytic domain + Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain + Glycerol-3-phosphate acyltransferase, PlsY + MotA/TolQ/ExbB proton channel + Maltose transport system permease protein MalF N-terminal domain + Peptidase S16, Lon proteolytic domain + Phosphoglycerate kinase, N-terminal + Glutathione S-transferase, N-terminal + L,D-transpeptidase catalytic domain + STAS domain + Asp/Glu/hydantoin racemase + Aconitase A/isopropylmalate dehydratase small subunit, swivel domain + Semialdehyde dehydrogenase, NAD-binding + Transglycosylase SLT domain 1 + Restriction endonuclease type IV, Mrr + Putative regulatory protein, FmdB, Zinc ribbon domain + START-like domain + Phospholipid methyltransferase + Restriction endonuclease, type I, HsdR, N-terminal + Protein of unknown function DUF86 + RNA polymerase sigma-70 region 1.2 + HNH endonuclease + Glycosyl transferase, family 4 + Histidine triad (HIT) protein + DeoC/FbaB/ lacD aldolase + Glycoside hydrolase 38/57, N-terminal domain + Amino acid exporter protein, LeuE-type + Holliday junction DNA helicase ruvB, N-terminal + ATPase, alpha/beta subunit, nucleotide-binding domain, active site + Gingipain + Clp protease proteolytic subunit /Translocation-enhancing protein TepA + Phosphoglycerate kinase + Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, C-terminal + Dihydroorotate dehydrogenase domain + DDH domain + Class II aldolase/adducin N-terminal + Lysylphosphatidylglycerol synthetase/glycosyltransferase AglD + 2-oxo acid dehydrogenase, lipoyl-binding site + Nickel-dependent hydrogenase, large subunit + CARDB domain + Glycine cleavage T-protein-like, N-terminal + Fumarylacetoacetase, C-terminal-related + RNA polymerase sigma-70 region 3 + Nitronate monooxygenase + Cys/Met metabolism, pyridoxal phosphate-dependent enzyme + ATPase, F1/V1 complex, beta/alpha subunit, C-terminal + Phosphofructokinase domain + Semialdehyde dehydrogenase, dimerisation domain + Aminoglycoside phosphotransferase + Ribbon-helix-helix protein, CopG + Alpha-D-phosphohexomutase superfamily + Methyltransferase FkbM + Fumarate lyase, conserved site + Aconitase family, 4Fe-4S cluster binding site + Tubulin/FtsZ, 2-layer sandwich domain + Peptidase S8, subtilisin, Ser-active site + Adenylyl cyclase class-3/4/guanylyl cyclase + DNA topoisomerase, type IA, central + NYN domain, limkain-b1-type + Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL), catalytic domain + Poly A polymerase, head domain + Mandelate racemase/muconate lactonizing enzyme, N-terminal domain + DNA topoisomerase, type IIA, central domain + TGS + TRAP transporter permease protein + RecF/RecN/SMC, N-terminal + RmlD-like substrate binding domain + P-type ATPase, cytoplasmic domain N + Peptidase S54, rhomboid domain + Cyclophilin-like domain + Inositol monophosphatase-like + SNARE associated Golgi protein + Domain of unknown function DUF1080 + Zn-dependent metallo-hydrolase, RNA specificity domain + FAD-binding domain + GroEL-like apical domain + Ankyrin repeat-containing domain + ADC synthase + DnaJ domain, conserved site + tRNA-guanine(15) transglycosylase-like + Domain of unknown function DUF4976 + DNA-directed DNA polymerase, family A, palm domain + Isochorismatase-like + Glutamyl/glutaminyl-tRNA synthetase, class Ib, alpha-bundle domain + Serine/threonine-protein kinase, active site + AhpD-like + Putative deacetylase LmbE-like domain + DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat + DNA helicase DnaB, N-terminal/DNA primase DnaG, C-terminal + Exonuclease, RNase T/DNA polymerase III + Carbohydrate kinase, FGGY, conserved site + Aspartyl/Asparaginyl-tRNA synthetase, class IIb + ATP-cone domain + TatD family + Patatin-like phospholipase domain + Protein of unknown function DUF2283 + Aminotransferase class-V, pyridoxal-phosphate binding site + Homing endonuclease + FeoB-type guanine nucleotide-binding (G) domain + Phenylalanyl-tRNA synthetase + Enolase, C-terminal TIM barrel domain + SecA DEAD-like, N-terminal + Penicillin-binding protein, dimerisation domain + tRNA(Ile)-lysidine/2-thiocytidine synthase, N-terminal + Methylthiotransferase + Glutamyl/glutaminyl-tRNA synthetase + PUA domain + GroES chaperonin family + Acylphosphatase-like domain + DNA-directed RNA polymerase, subunit 2, domain 6 + Hedgehog signalling/DD-peptidase zinc-binding domain + Peptidase M24, methionine aminopeptidase + Glycoside hydrolase, family 3, N-terminal + ClpA/B, conserved site 1 + TRAM domain + Heat shock protein 70kD, peptide-binding domain + K Homology domain, type 2 + ABC-2 family transporter protein + DNA topoisomerase, type IIA, subunit B + Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain + Glycosyl transferase, family 3 + Cellulosome anchoring protein, cohesin domain + Pyrophosphate-energised proton pump + Methylthioribose-1-phosphate isomerase-like, N-terminal domain + Tetratricopeptide repeat 2 + RNA polymerase Rpb1, domain 5 + Cation efflux protein + LarA-like, N-terminal + Crp-type HTH domain + Primosome PriB/single-strand DNA-binding + 50S ribosomal protein L30e-like + ArgJ-like domain + tRNA-binding domain + Arginine repressor C-terminal-like domain + Protein-export membrane protein SecD/SecF, bacterial + Haemolysin-type calcium-binding repeat + Glutamine synthetase, beta-Grasp domain + Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal + PEP-CTERM protein-sorting domain + Transport-associated OB, type 2 + DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta + Chromosomal replication initiator protein DnaA + Methylenetetrahydrofolate reductase + Methylmalonyl-CoA mutase, C-terminal + NAD kinase + Thioredoxin + Polyprenyl synthetase, conserved site + Signal recognition particle, SRP54 subunit, helical bundle + ATP-dependent 6-phosphofructokinase + 3'-5' exonuclease domain + V-ATPase proteolipid subunit C-like domain + Dihydrofolate reductase-like domain + Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain + P-type ATPase, phosphorylation site + Ribosomal protein L25/Gln-tRNA synthetase, beta-barrel domain + Protein of unknown function DUF4445 + SecY/SEC61-alpha family + PLC-like phosphodiesterase, TIM beta/alpha-barrel domain + Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead + FKBP-type peptidyl-prolyl cis-trans isomerase domain + Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal + Alpha-D-phosphohexomutase, conserved site + DAHP synthetase I/KDSA + Uncharacterised protein family UPF0047 + D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 + Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding + Thiamine pyrophosphate enzyme, central domain + KOW + Nucleotide sugar epimerase + ParB/RepB/Spo0J partition protein family + Transmembrane protein TqsA-like + ATPase, AAA-3 + 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III + General secretory system II, protein E, N-terminal + Flavoprotein + DNA mismatch repair protein MutS, C-terminal + Decaprenyl diphosphate synthase-like + Protein of unknown function DUF1559 + ABC-2 transporter + Peptidase M41 + 6-phosphogluconate dehydrogenase, NADP-binding + Staphylococcal nuclease (SNase-like), OB-fold/extended TUDOR domain + Cell shape determining protein MreB + Ribose-phosphate diphosphokinase + Peptidoglycan binding-like + Enolase + ATP-citrate lyase/succinyl-CoA ligase + Biopolymer transport protein ExbD/TolR + TsaA-like domain + Uncharacterised protein family UPF0758, conserved site + tRNA nucleotidyltransferase/poly(A) polymerase, RNA and SrmB- binding domain + Polysaccharide biosynthesis protein, CapD-like domain + Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like + NusB/RsmB/TIM44 + Carbamoyl-phosphate synthase large subunit, CPSase domain + DNA recombination and repair protein RecA + Aspartate carbamoyltransferase + RNA polymerase Rpb1, domain 1 + Glyceraldehyde/Erythrose phosphate dehydrogenase family + Pseudouridine synthase, RluC/RluD, conserved site + Prolipoprotein diacylglyceryl transferase + ABC transporter periplasmic binding domain + DALR anticodon binding + HpcH/HpaI aldolase/citrate lyase domain + Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain + NusG, N-terminal + Oxidoreductase, FAD-binding domain + Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain + Adenosylhomocysteinase-like + Protein of unknown function DUF433 + Peptide deformylase + TRAP transporter solute receptor, TAXI family + ATPase, AAA-type, conserved site + DNA topoisomerase, type IIA, subunit B, domain 2 + Aminoacyl-tRNA synthetase, class I, anticodon-binding domain, subdomain 2 + DNA recombination-mediator protein A + 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain + Helicase HerA, central domain + Sodium/calcium exchanger membrane region + NIF system FeS cluster assembly, NifU, N-terminal + Cold-shock conserved site + Zinc-ribbon domain + Aldehyde dehydrogenase, cysteine active site + Phosphatidic acid phosphatase type 2/haloperoxidase + PhoU domain + ADP-ribosylation/Crystallin J1 + Transcriptional regulator TACO1-like + Protein kinase, ATP binding site + NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site + Ribosomal RNA small subunit methyltransferase H + Ribosomal protein L5 domain + [2Fe-2S]-binding + MmgE/PrpD + tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG-related + Transcription elongation factor, GreA/GreB, C-terminal + YbaK/aminoacyl-tRNA synthetase-associated domain + Type IIA DNA topoisomerase subunit A, alpha-helical domain + Adenylosuccinate synthetase + tRNA synthetases class I, catalytic domain + Orn/DAP/Arg decarboxylase 2, N-terminal + Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain + Predicted permease DUF318 + Single-stranded DNA-binding protein + Glycine cleavage T-protein, C-terminal barrel domain + MIP18 family-like + Sporulation-related domain + Glycine cleavage system P protein + Bacterial general secretion pathway protein G-type pilin + Glycoside hydrolase, family 29 + Magnesium chelatase ChlI domain + SUF system FeS cluster assembly, SufBD + Peptidoglycan biosynthesis protein MurJ + PBP domain + Triosephosphate isomerase + Aspartyl/Glutamyl-tRNA(Gln) amidotransferase, subunit B/E, catalytic + DNA-directed RNA polymerase, RpoA/D/Rpb3-type + Aldehyde dehydrogenase, glutamic acid active site + Transcription regulator IclR, N-terminal + Electron transfer flavoprotein, alpha subunit, C-terminal + DNA primase, catalytic core, N-terminal + Toll/interleukin-1 receptor homology (TIR) domain + Domain of unknown function DUF21 + GrpE nucleotide exchange factor + Forkhead-associated (FHA) domain + Peptidase S26A, signal peptidase I + YjgF/YER057c/UK114 family + Prismane-like, alpha/beta-sandwich + Glutamate synthase domain + RNA polymerase, alpha subunit, C-terminal + ABC transporter, FecCD-like + Methyltransferase small domain + Arginyl-tRNA synthetase, catalytic core domain + TonB, C-terminal + PurE domain + CobW/HypB/UreG, nucleotide-binding domain + NAD-dependent DNA ligase, adenylation + ATP-dependent Clp protease proteolytic subunit + UmuC domain + FtsK domain + B3/B4 tRNA-binding domain + Protein translocase subunit SecA + Gingipain, N-terminal + Tetrahydrofolate dehydrogenase/cyclohydrolase + Protein-export membrane protein SecD/SecF/SecDF, conserved site + ABC-transporter extension domain + Carboxymuconolactone decarboxylase-like + HTH domain AraC-type, conserved site + Zinc finger, RING/FYVE/PHD-type + Chorismate-utilising enzyme, C-terminal + Glycosyl transferase, family 28, C-terminal + Histone deacetylase superfamily + DNA polymerase, helix-hairpin-helix motif + Histidinol dehydrogenase + Peptidase M28 + Ribosomal RNA adenine methyltransferase KsgA/Erm + Ribosomal protein S2 + Quinolinate phosphoribosyl transferase, N-terminal + Dihydroxy-acid/6-phosphogluconate dehydratase, conserved site + Adenylate kinase/UMP-CMP kinase + ATP-dependent (S)-NAD(P)H-hydrate dehydratase + Transcriptional regulator TACO1-like, domain 3 + N-acetylglucosaminyl phosphatidylinositol deacetylase-related + NfeD-like, C-terminal domain + Protein of unknown function DUF112, transmembrane + Peptidyl-prolyl cis-trans isomerase, PpiC-type + Methylmalonyl-CoA mutase, alpha chain, catalytic + Transcription regulator IclR, C-terminal + Coenzyme F420 hydrogenase/dehydrogenase beta subunit, C-terminal + Transcription regulator HTH, AraC- type + Ribonuclease HII/HIII domain + Lon, substrate-binding domain + Pyridoxamine 5'-phosphate oxidase, putative + Type II/III secretion system + tRNA dimethylallyltransferase + Ribulose-phosphate 3-epimerase-like + Chaperonin Cpn60 + D12 class N6 adenine-specific DNA methyltransferase + Protein of unknown function DUF45 + Transaldolase/Fructose-6-phosphate aldolase + Flagellar basal body rod protein, N-terminal + Initiation factor 2B-related + Peptidase M42 + Mannoside phosphorylase + Ribose-phosphate pyrophosphokinase, N-terminal domain + C-5 cytosine methyltransferase + Ribosomal protein L4 domain + Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain + YjeF N-terminal domain + Beta-ketoacyl synthase, active site + Membrane insertase OXA1/ALB3/YidC + DJ-1/PfpI + Ferrous iron transport protein B, C-terminal + Enolase, N-terminal + ClpA/B, conserved site 2 + Transcription regulator Rrf2-type + RadC protein + DNA gyrase B subunit, C-terminal + YqgF/RNase H-like domain + Heat shock protein 70kD, C-terminal domain + Sirtuin family + CTP synthase, N-terminal + Methioninyl-tRNA synthetase core domain + Chromosomal replication control, initiator DnaA-like + E3-binding domain + Protein of unknown function DUF5320 + Phosphate acetyl/butaryl transferase + Fructose-bisphosphate aldolase, class-II + Ribosomal protein L6, alpha-beta domain + Nickel-dependent hydrogenase, large subunit, nickel binding site + SEC-C motif + THIF-type NAD/FAD binding fold + Quinolinate phosphoribosyl transferase, C-terminal + Zinc finger, DksA/TraR C4-type + GrpE nucleotide exchange factor, head + Proteasome assembly chaperone 2 + Cation transporter + Homocysteine-binding domain + Sec-independent protein translocase protein TatA/B/E + Ribosomal protein L13 + Gamma-glutamyltranspeptidase + Amino acid/polyamine transporter I + CinA, C-terminal + Transporter-associated domain + DNA polymerase III, beta chain, central + Amino acid ABC transporter, permease protein, 3-TM domain + RNA polymerase Rpb2, domain 2 + DNA polymerase A + Glutamate/acetylglutamate kinase + Protein of unknown function DUF72 + PilZ domain + MEMO1 family + Type I restriction enzyme R protein, N-terminal domain + tRNA-splicing ligase, RtcB + Acylphosphatase, conserved site + Peptidase S8, subtilisin, Asp-active site + Pentapeptide repeat + Transposase IS204/IS1001/IS1096/IS1165, DDE domain + Biotin carboxylase-like, N-terminal domain + 4Fe-4S domain + Translation elongation factor EFTs/EF1B, dimerisation + Sugar-phosphate isomerase, RpiB/LacA/LacB family + Pyruvate kinase, C-terminal + Stomatin family + DNA helicase, DnaB-like, N-terminal + ATPase, dynein-related, AAA domain + Formate-tetrahydrofolate ligase, FTHFS + GxxExxY protein + Ribonuclease III domain + Permease LptG/LptF-related + 4'-phosphopantetheinyl transferase superfamily + Rnf-Nqr subunit, membrane protein + SGNH hydrolase-type esterase domain + Peptidyl-tRNA hydrolase + Ribosomal protein L4/L1e + RelA/SpoT + Fatty acid synthesis PlsX protein + Ham1-like protein + Recombinase, conserved site + ATP-dependent DNA helicase RecG, C-terminal domain + Protein of unknown function DUF3795 + Molybdopterin dehydrogenase, FAD-binding + Ribosomal protein L1/ribosomal biogenesis protein + Peptidase M14, carboxypeptidase A + Threonine-tRNA ligase, class IIa + SH3-like domain, bacterial-type + Polysaccharide chain length determinant N-terminal domain + Aromatic amino acid beta-eliminating lyase/threonine aldolase + Acylneuraminate cytidylyltransferase + Kelch-type beta propeller + Orotidine 5'-phosphate decarboxylase domain + Leucine-tRNA ligase + Cytochrome c oxidase-like, subunit I domain + NAD(+) synthetase + Rieske [2Fe-2S] iron-sulphur domain + Argininosuccinate synthase + Hydroxylamine reductase/Ni-containing CO dehydrogenase + NTP pyrophosphohydrolase MazG, putative catalytic core + SAICAR synthetase/ADE2, N-terminal + 5'-3' exonuclease, alpha-helical arch, N-terminal + SecA Wing/Scaffold + Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain + ATP synthase, F1 complex, gamma subunit + Nucleoside diphosphate kinase-like domain + Staphylococcal nuclease (SNase-like), OB-fold + ThiamineS/Molybdopterin converting factor subunit 1 + GrpE nucleotide exchange factor, coiled-coil + Glycerophosphodiester phosphodiesterase domain + Ribosomal protein L18e/L15P + Translation elongation factor EFTu/EF1A, C-terminal + IMP dehydrogenase/GMP reductase + dTDP-4-dehydrorhamnose 3,5-epimerase-related + Ribosomal protein S9 + CarD-like/TRCF domain + Glutaredoxin + Tryptophan-tRNA ligase + HD/PDEase domain + Trigger factor, C-terminal + SCP2 sterol-binding domain + Ribosomal protein L14P + Membrane transport protein MMPL domain + Tyrosine-tRNA ligase + DNA topoisomerase, type IA, zn finger + tRNA methyltransferase TRMD/TRM10-type domain + LVIVD + CoA enzyme activase + Peptidase S8, subtilisin, His-active site + Asn/Gln amidotransferase + Glutamate/phenylalanine/leucine/valine dehydrogenase + OsmC/Ohr family + Ribosomal protein S8 + DeoR-type HTH domain + Iron dependent repressor, metal binding and dimerisation domain + Peptidase S49 + Ribosomal protein S30Ae/sigma 54 modulation protein + Prepilin type IV endopeptidase, peptidase domain + Peptidase HybD-like domain + Cell division protein FtsZ, C-terminal + Creatininase-like domain + Ribosome recycling factor domain + Chorismate synthase + Biotin carboxylase, C-terminal + Ribosomal protein S13 + Citrate transporter-like domain + Crossover junction endodeoxyribonuclease RuvC + Translation initiation factor IF- 2, domain 3 + Ribosomal protein S2, bacteria/mitochondria/plastid + Bacterial surface antigen (D15) + Cytochrome C biogenesis protein, transmembrane domain + Domain of unknown function DUF58 + Ribosomal protein L10e/L16 + Alanine-tRNA ligase, class IIc + ATP:cob(I)alamin adenosyltransferase CobA/CobO/ButR + Cation efflux protein, cytoplasmic domain + Flagellar basal-body/hook protein, C-terminal domain + Transcription elongation factor, GreA/GreB, N-terminal + NADH:ubiquinone oxidoreductase, subunit 1/F420H2 oxidoreductase subunit H + Molybdopterin oxidoreductase, prokaryotic, conserved site + ComEC/Rec2-related protein + PEP-utilising enzyme, active site + Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain + Formyl transferase, C-terminal + Heparinase II/III-like + Phosphoenolpyruvate carboxykinase, C-terminal + Ureohydrolase + DNA-binding HTH domain, TetR-type, conserved site + Trigger factor, ribosome-binding, bacterial + TerB-like + DNA-directed RNA polymerase, insert domain + Peptidase M3A/M3B catalytic domain + Phosphoadenosine phosphosulphate reductase + LOG family + Phosphotyrosine protein phosphatase I superfamily + Pyridine nucleotide-disulphide oxidoreductase, class I, active site + Glycosyl transferase family 3, N-terminal domain + Polyketide cyclase SnoaL-like domain + AMP-dependent ligase, C-terminal + Arginine-tRNA ligase + DNA polymerase III, beta chain, C-terminal + Riboflavin kinase domain + Ribosomal protein L5, C-terminal + Isocitrate/isopropylmalate dehydrogenase, conserved site + Serine/threonine dehydratase, pyridoxal-phosphate-binding site + DNA polymerase, Y-family, little finger domain + Aldo/keto reductase + Ferritin/DPS protein domain + NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding + Ribosomal protein L11, N-terminal + ABC transporter substrate-binding protein PnrA-like + Ribosomal protein L25/L23 + Uncharacterised conserved protein UCP033563 + Metalloprotease catalytic domain, predicted + Ribosomal protein S11 + Putative esterase + Quinolinate synthetase A + Signal transduction histidine kinase, phosphotransfer (Hpt) domain + Phosphotransferase/anion transporter + Integrase, N-terminal zinc-binding domain-like + Ribosomal protein S7 domain + Thiolase + Guanylate kinase/L-type calcium channel beta subunit + Transcription factor NusA, N-terminal + Valine-tRNA ligase + ATP synthase, F0 complex, subunit A + Sialidases + RNA polymerase Rpb1, domain 3 + Dephospho-CoA kinase + MoeA, N-terminal and linker domain + SsrA-binding protein + RNA polymerase, beta subunit, protrusion + Ferrodoxin-fold anticodon-binding domain + Arginyl tRNA synthetase N-terminal domain + Ribosomal protein L11, C-terminal + Acyl transferase + Biotin-binding site + Ribosomal protein S12/S23 + ABC/ECF transporter, transmembrane component + Recombinase zinc beta ribbon domain + Ornithine/DAP/Arg decarboxylase + SLC26A/SulP transporter domain + Ribosomal protein L10P + Ribosomal protein S17/S11 + Translation elongation factor, KOW-like + Ribosomal protein S15 + Ribokinase/fructokinase + Helix-turn-helix, type 11 + Inosine/uridine-preferring nucleoside hydrolase domain + D-alanine--D-alanine ligase, C-terminal + Oxidoreductase, molybdopterin-binding domain + DNA polymerase III, beta chain, N-terminal + MoaA/nifB/pqqE, iron-sulphur binding, conserved site + ATP-dependent RNA helicase DEAD-box, conserved site + Survival protein SurE-like phosphatase/nucleotidase + ArgE/DapE/ACY1/CPG2/YscS, conserved site + Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal + Ornithine/putrescine carbamoyltransferase + BRCT domain + Aminotransferase, class-II, pyridoxal-phosphate binding site + Domain of unknown function DUF89 + MgsA AAA+ ATPase C-terminal + Endoribonuclease YbeY + Integrase, DNA-binding domain + KH domain, NusA-like + Thiolase, conserved site + N-acetylmuramoyl-L-alanine amidase, catalytic domain + Peptidase M1, membrane alanine aminopeptidase, N-terminal + NADH-quinone oxidoreductase, subunit D + Domain of unknown function DUF933 + DNA recombination and repair protein RecA, C-terminal + PTS EIIA type-2 domain + dUTPase-like + IrrE N-terminal-like domain + UbiD decarboxylyase family + Bacterial bifunctional deaminase-reductase, C-terminal + Chemotaxis methyl-accepting receptor + Aliphatic acid kinase, short-chain + HNH nuclease + Small protein B + ATP synthase, F0 complex, subunit b/b', bacterial/chloroplast + Phenylacetic acid degradation-related domain + RNA-binding domain, S1, IF1 type + 30s ribosomal protein S13, C-terminal + Ribosomal protein L2, C-terminal + PEP-utilising enzyme, conserved site + Alcohol dehydrogenase, iron-type, conserved site + Glycosyl hydrolase family 38, C-terminal + RNA polymerase, alpha subunit + Ribosomal protein L22/L17 + Heavy metal-associated domain, HMA + Ribosomal protein S5, C-terminal + Ribosomal protein L5, N-terminal + CO dehydrogenase/acetyl-CoA synthase delta subunit, TIM barrel + SecA preprotein, cross-linking domain + Creatininase/formamide hydrolase + FtsK gamma domain + DNA topoisomerase, type IA, central region, subdomain 2 + Ammonium transporter AmtB-like domain + Homoserine dehydrogenase, catalytic + Putative zinc-finger + Ribosomal protein L17 + Cupredoxin + 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK + tRNA-dihydrouridine synthase + Orn/DAP/Arg decarboxylase 2, C-terminal + CheW-like domain + Kae1/TsaD family + LytTR DNA-binding domain + DnaA N-terminal domain + Ribosomal protein L7/L12, C-terminal + 5'-3' exonuclease, C-terminal domain + NIF system FeS cluster assembly, NifU, C-terminal + LexA repressor, DNA-binding domain + Diaminopimelate epimerase, DapF + UvrC family homology region + Ribosomal protein S3, C-terminal + DNA polymerase III, alpha subunit + Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal + Isoleucine-tRNA ligase + MraZ domain + NADH:ubiquinone oxidoreductase + DNA topoisomerase, type IIA, conserved site + GTP cyclohydrolase II + RNA recognition motif domain + Malic enzyme, N-terminal domain + AICARFT/IMPCHase bienzyme + Pyrroline-5-carboxylate reductase, catalytic, N-terminal + Pyrrolo-quinoline quinone-like domain + GTP1/OBG domain + Ribosomal protein L19 + DNA/pantothenate metabolism flavoprotein, C-terminal + Pseudouridine synthase I, TruA, alpha/beta domain + Serine-tRNA synthetase, type1, N-terminal + Ribosomal Proteins L2, RNA binding domain + F-type ATP synthase subunit B-like, membrane domain + Amine oxidase + Aminotransferase, class IV, conserved site + Ribosomal protein S2, conserved site + Sulphur transport domain + Ribosomal protein S6 + Cysteinyl-tRNA synthetase/mycothiol ligase + Ribosomal protein S10 domain + Thiolase, active site + Beta-hydroxydecanoyl thiol ester dehydrase, FabA/FabZ + Ketopantoate hydroxymethyltransferase + GspD/PilQ family + tRNA synthetase, B5-domain + rRNA adenine dimethylase-like + Acetyl-coenzyme A synthetase, N-terminal domain + AICAR transformylase domain + WD40 repeat + UbiC transcription regulator-associated + Ribosomal protein L18 + TGS-like domain + Glycosyl transferase, family 9 + Citrate synthase + Recombination protein O, RecO + FAD synthetase + Pyruvate kinase, barrel + Elongation factor P, C-terminal + GMP synthase, C-terminal + Membrane insertase YidC/Oxa1, C-terminal + Ribosomal protein S4/S9, N-terminal + Pseudouridine synthase II, N-terminal + Translation elongation factor P/YeiP, central + Malic enzyme, NAD-binding + Ribosomal protein S19, superfamily + Arginine biosynthesis protein ArgJ + Putative pre-16S rRNA nuclease + Heat shock protein DnaJ, cysteine-rich domain + Ribosomal protein S5, N-terminal + Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain + Adenylate kinase, conserved site + ABC transporter, TroCD-like + NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site + Hedgehog/Intein (Hint) domain + Thiolase, acyl-enzyme intermediate active site + Ribosomal protein S19/S15 + Prephenate dehydrogenase + Ribosomal protein S20 + NHL repeat + Phenylalanine-tRNA ligase, class II, N-terminal + Fe-S hydro-lyase, tartrate dehydratase alpha-type, catalytic domain + Ornithine cyclodeaminase/mu-crystallin + Dihydrodipicolinate reductase, N-terminal + 2,3-bisphosphoglycerate-independent phosphoglycerate mutase + SecY conserved site + Ribosomal protein L20 C-terminal domain + Folylpolyglutamate synthetase, conserved site + Phosphopantetheine attachment site + Peptidase A31 family + Hydrolyase LeuD/HacB/DmdB + Phospho-N-acetylmuramoyl-pentapeptide transferase, conserved site + Riboflavin kinase domain, bacterial/eukaryotic + Translation initiation factor 3, C-terminal + Ribosomal protein L20 + Peptidase A8, signal peptidase II + Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain + Cytochrome c oxidase subunit I + Phosphoenolpyruvate carboxykinase, N-terminal + Mg chelatase-related protein, C-terminal domain + Leucyl-tRNA synthetase, editing domain + Domain of unknown function DUF4162 + BFD-like [2Fe-2S]-binding domain + ATP phosphoribosyltransferase, catalytic domain + Phosphate transporter + tRNA threonylcarbamoyl adenosine modification protein TsaE + Bacterial lipid A biosynthesis acyltransferase + 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial-type + RNA polymerase Rpb2, domain 3 + Uncharacterised protein family UPF0102 + S-adenosylmethionine:tRNA ribosyltransferase-isomerase, QueA + ATP-grasp fold, succinyl-CoA synthetase-type + Argininosuccinate synthetase, catalytic/multimerisation domain body + Aquaporin-like + Ribosomal protein L21-like + 3-dehydroquinate synthase domain + S-adenosyl-L-homocysteine hydrolase, NAD binding domain + ISXO2-like transposase domain + Rho termination factor, N-terminal + Ribosomal protein L2, domain 3 + Capsule synthesis protein, CapA + Pseudouridine synthase I, TruA, C-terminal + MoeA, C-terminal, domain IV + Ribosomal protein S16 domain + RlpA-like protein, double-psi beta-barrel domain + CO dehydrogenase flavoprotein, C-terminal + Deoxyribonuclease, TatD-related, conserved site + Glycine cleavage system H-protein/Simiate + Polyribonucleotide nucleotidyltransferase, RNA-binding domain + Ribosomal protein L3 + P22 tailspike C-terminal domain-like + PEGA + Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain + Nucleoid-associated protein YbaB/EbfC family + Protein-L-isoaspartate(D-aspartate) O-methyltransferase + Ribosomal protein L16 + Ribosomal protein L24 + Dihydroorotase, conserved site + Ribosomal protein L29/L36 + Translation initiation factor 3 + S-adenosylmethionine synthetase, C-terminal + Endolytic murein transglycosylase + Zinc finger, FPG/IleRS-type + HAD-superfamily hydrolase, subfamily IIB + Double-stranded RNA-binding domain + Double zinc ribbon + Ribosomal protein S10 + Ribonucleoside-triphosphate reductase, anaerobic + Serine-tRNA ligase, type1 + Ribosomal protein L13, bacterial-type + Ribosomal protein S3, bacterial + Peptidase M24A, methionine aminopeptidase, subfamily 1 + Ribosomal protein L7/L12, oligomerisation + Acetohydroxy acid isomeroreductase, NADPH-binding domain + Citrate synthase-like, large alpha subdomain + Cytochrome c assembly protein + DNA methylase, C-5 cytosine-specific, active site + Ribosomal protein L9, C-terminal + ATP-NAD kinase, PpnK-type, all-beta + Lysyl-tRNA synthetase, class II, C-terminal + Glycoside hydrolase, family 5 + TPP-binding enzyme, conserved site + DeoR C-terminal sensor domain + Undecaprenyl-diphosphatase UppP + Phosphoenolpyruvate carboxykinase, ATP-utilising + GspF/PilC family + Amidohydrolase + Molybdenum cofactor biosynthesis, conserved site + Shikimate kinase/gluconokinase + Nucleoside diphosphate kinase + SsuA/THI5-like + AMMECR1 domain + Protein of unknown function DUF4258 + 3,4-dihydroxy-2-butanone 4-phosphate synthase, RibB + Type IV pilus assembly protein PilM + POTRA domain, BamA/TamA-like + Lumazine/riboflavin synthase + Ribosomal protein S15, bacterial-type + Transcription antitermination protein, NusG + Anthranilate synthase component I-like + DNA polymerase III, beta chain + Kynurenine formamidase + S-adenosyl-L-methionine-dependent methyltransferase, MraW, recognition domain + Enolase, conserved site + Pseudouridine synthase, RsuA/RluB/E/F, conserved site + AAA+ ATPase domain + 4-hydroxy-3-methylbut-2-enyl diphosphate reductase + Ribosomal RNA adenine methylase transferase, conserved site + Cytidylate kinase domain + NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminal + S-adenosylmethionine synthetase, conserved site + RNA polymerase Rpb2, domain 7 + Aspartate/homoserine dehydrogenase, NAD-binding + Ribosomal protein S16 + Macro domain + Translation initiation factor IF-2, N-terminal + Rho termination factor, RNA-binding domain + Proline-tRNA ligase, class IIa + Putative zinc- or iron-chelating domain containing protein + Modification methylase HemK + Dihydroorotate dehydrogenase, conserved site + Glycosyl hydrolases family 2, sugar binding domain + Renal dipeptidase family + Ribosomal protein L27 + Alanine racemase + Adenine nucleotide alpha hydrolase-like domains + Histone-like DNA-binding protein, conserved site + SAF domain + Regulatory factor, effector binding domain + Flagellin, D0/D1 domain + Pantoate-beta-alanine ligase + Phosphomethylpyrimidine synthase + Thymidylate synthase/dCMP hydroxymethylase domain + AMMECR1, N-terminal + Domain of unknown function DUF559 + Glycine radical domain + Glycoside hydrolase family 38, N-terminal domain + Allosteric substrate binding domain + Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase + Translation initiation factor 3, N-terminal + DNA helicase, Holliday junction RuvA type, domain I, bacterial + D-Tyr tRNAtyr deacylase-like domain + Schiff base-forming aldolase, active site + Phosphopantetheine adenylyltransferase + Peptidase M17, leucyl aminopeptidase, C-terminal + YdiL-like domain + Ribosomal protein L9, N-terminal + Transposase, IS801/IS1294 + Type III pantothenate kinase + 6-pyruvoyl tetrahydropterin synthase/QueD family protein + Preprotein translocase SecG subunit + Ribosomal protein L1, 3-layer alpha/beta-sandwich + 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate + Glutathione S-transferase, C-terminal + Ribonuclease E inhibitor RraA/RraA-like protein + Coenzyme F420 hydrogenase/dehydrogenase beta subunit, N-terminal + Protein of unknown function DUF3160 + Thymidylate synthase ThyX + Peroxiredoxin, C-terminal + D-aminoacyl-tRNA deacylase DTD + Di-trans-poly-cis-decaprenylcistransferase-like, conserved site + Acyl carrier protein (ACP) + DNA-directed RNA polymerase, beta subunit, external 1 domain + Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal + DNA mismatch repair protein MutS, core + Transcription regulator HTH, AsnC-type, conserved site + Formamidopyrimidine-DNA glycosylase, catalytic domain + DNA topoisomerase, type IA, active site + Ribosomal protein L6, bacterial-type + Thiamine phosphate synthase/TenI + WYL domain + Solute-binding protein family 5, conserved site + Prephenate dehydratase + Ribosomal protein L15, bacterial-type + Imidazoleglycerol-phosphate dehydratase + SHS2 domain inserted in FtsA + Smr domain + Helix-hairpin-helix motif + NADH:ubiquinone oxidoreductase, 30kDa subunit + DTXR-type HTH domain + Anthranilate synthase component I, N-terminal + Colicin V production, CvpA + GATS-like ACT domain + NAD-dependent DNA ligase, OB-fold + DNA helicase, Holliday junction RuvB type, C-terminal + Translation initiation factor IF-1 + Prepilin-type processing-associated H-X9-DG domain + Polyphosphate kinase-2-related + TSP type-3 repeat + Carbohydrate-binding domain, family 9 + Flagellar motor switch protein FliG, alpha-helical + Ribosomal protein S19 conserved site + S-adenosylmethionine synthetase, N-terminal + Ribosome-binding factor A + Transport-associated OB, type 1 + Sulfotransferase domain + Cell division protein FtsA + Zinc finger, NHR/GATA-type + Lumazine-binding domain + Ribosomal protein L9, bacteria/chloroplast + Glu-tRNAGln amidotransferase C subunit + Glyceraldehyde 3-phosphate dehydrogenase, active site + Ribosomal protein L21 + Peptide methionine sulphoxide reductase MsrA + Valyl-tRNA synthetase, tRNA-binding arm + Ribosomal protein L2, bacterial/organellar-type + Leucine-rich repeat + Alpha/beta hydrolase fold-3 + HpaB/PvcC/4-BUDH N-terminal + Ribosomal protein L14P, conserved site + Glycoside hydrolase family 3 C-terminal domain + NusB antitermination factor + Ribosomal protein L7/L12 + PA14 domain + Pseudouridine synthase, RsuA/RluB/E/F + Ribosomal protein L25 + Glycerol-3-phosphate dehydrogenase, NAD-dependent + Uncharacterised domain YOR215C, mitochondrial + DNA replication/recombination mediator RecO, N-terminal + DNA mismatch repair protein MutS, connector domain + Sodium:dicarboxylate symporter + Peptidase S26A, signal peptidase I, conserved site + DNA mismatch repair protein MutS, N-terminal + CAP domain + Chromosomal replication control, initiator DnaA, conserved site + 3-keto-5-aminohexanoate cleavage enzyme + Glycoside hydrolase family 2, catalytic domain + RecG, wedge domain + S-adenosyl-L-homocysteine hydrolase, conserved site + Ribosomal protein S12, bacterial-type + Maf-like protein + Biotin--acetyl-CoA-carboxylase ligase + Uracil-DNA glycosylase family 4 + ATP synthase, F1 complex, delta/epsilon subunit, N-terminal + Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich + Protein of unknown function DUF3387 + Bifunctional nuclease domain + Ribonucleotide reductase large subunit, N-terminal + DNA polymerase III delta, N-terminal + Beta-L-arabinofuranosidase, GH127 + Chloride channel, core + Protein translocase complex, SecE/Sec61-gamma subunit + R3H domain + Cation-transporting P-type ATPase, C-terminal + Transposase IS605, OrfB, C-terminal + SLC41 divalent cation transporters, integral membrane domain + Uncharacterised protein family UPF0175 + GTP cyclohydrolase I domain + Glutamine synthetase, glycine-rich site + Ribosomal protein L11, bacterial-type + 50S ribosomal protein uL4 + RNA polymerase, beta subunit, conserved site + Thymidylate kinase + Adenylate kinase, active site lid domain + Ribosomal protein L31 + DNA mismatch repair protein MutS-like, N-terminal + Zinc finger, MqsA-type + Recombination protein RecR, C4-type zinc finger + SecE subunit of protein translocation complex + Hydrogenase formation HypD protein + S-adenosylmethionine synthetase, central domain + Phage integrase SAM-like domain + Pyrroline-5-carboxylate reductase, dimerisation domain + Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit + Saccharopine dehydrogenase, C-terminal + Ribosomal protein S19, bacterial-type + Cytochrome b561, bacterial/Ni-hydrogenase + Chorismate synthase, conserved site + Flavodoxin domain + Two component regulator propeller + Mut7-C RNAse domain + Chaperonin Cpn60, conserved site + Ribosomal protein L14P, bacterial-type + Glycine-tRNA ligase, beta subunit + Triosephosphate isomerase, active site + Polysaccharide export protein + Acetyl-CoA hydrolase/transferase C-terminal domain + rRNA small subunit methyltransferase G + Ribosomal protein L18, bacterial-type + Ribonuclease Y, N-terminal + Heat-inducible transcription repressor HrcA, C-terminal + Phosphoribosylglycinamide synthetase, N-terminal + Bordetella uptake gene + Pseudouridine synthase, RluC/RluD + tRNA threonylcarbamoyl adenosine modification protein TsaB + Ribosomal protein S18 + Ribonuclease P + Ribosomal protein L16, conserved site + UDP-N-acetylglucosamine 2-epimerase WecB-like + Double Cache domain 1 + Hydantoinase/oxoprolinase + Molybdopterin cofactor biosynthesis C (MoaC) domain + Ribosomal protein L22, bacterial/chloroplast-type + LemA + ATP synthase, alpha subunit, C-terminal + Ribosomal protein S13, bacterial-type + Shikimate dehydrogenase substrate binding, N-terminal + UvrD-like helicase C-terminal domain + Potassium channel domain + Sulphur relay, DsrE/F-like protein + Periplasmic binding protein/LacI sugar binding domain + Ribosomal protein S9, conserved site + Peptidase S26A, signal peptidase I, lysine active site + TusA-like domain + HNH endonuclease 5 + Regulatory protein RecX + Ribosomal protein L25, beta domain + Uncharacterised protein family UPF0145/C2CD5 + Ribosomal protein S21 + Antibiotic biosynthesis monooxygenase domain + ATP synthase, F0 complex, subunit C + Cation-transporting P-type ATPase, N-terminal + ATPase, OSCP/delta subunit + Peptidyl-tRNA hydrolase, conserved site + Ribosomal protein S13, conserved site + Protein of unknown function DUF169 + Cytidylyltransferase IspD/TarI + 5'-Nucleotidase, C-terminal + Translation elongation factor EFG/EF2 + Phosphoribosylglycinamide synthetase, C-domain + UvrB, YAD/RRR-motif-containing domain + Dihydrodipicolinate reductase, C-terminal + Folylpolyglutamate synthetase + AmmeMemoRadiSam system radical SAM enzyme + Protein of unknown function DUF541 + PRC-barrel domain + DNA glycosylase/AP lyase, H2TH DNA-binding + Transaldolase, active site + Saccharopine dehydrogenase, NADP binding domain + Nitrogen regulatory protein PII + Translation initiation factor aIF-2, bacterial-like + Acetohydroxy acid isomeroreductase C-terminal + GTPase HflX, N-terminal + Cysteinyl-tRNA synthetase, class Ia, DALR + UbiE/COQ5 methyltransferase + Aspartate kinase, conserved site + KaiC-like domain + Pyridoxal phosphate homeostasis protein + Asp/Glu racemase, active site 2 + Ribosomal protein S7, bacterial/organellar-type + Carbamoyl-phosphate synthetase, large subunit oligomerisation domain + UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal + Glycosyl hydrolase, family 4, C-terminal + Alanine racemase, C-terminal + DNA primase, DnaB-helicase binding domain + Ornithine cyclodeaminase, N-terminal + DNA recombination/repair protein RecA, conserved site + DNA mismatch repair protein, C-terminal + MutL, C-terminal, dimerisation + Vitamin B12-dependent methionine synthase, activation domain + DhaL domain + Indole-3-glycerol phosphate synthase + Inositol monophosphatase, metal-binding site + Protein of unknown function DUF167 + Signal recognition particle, SRP54 subunit, M-domain + Glycoside hydrolase, family 42, N-terminal + Spore coat protein CotH + HRDC domain + Ribosomal protein L1, conserved site + CGCAxxGCC motif + Ribosomal protein L3, bacterial/organelle-type + Argininosuccinate synthase, conserved site + Peptidase M42, domain 2 + NADH-quinone reductase NQR2/RnfD + DNA polymerase III, gamma subunit, domain III + Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site + 3-hydroxyisobutyrate dehydrogenase, NAD-binding domain + Aliphatic acid kinase, short-chain, conserved site + Outer membrane protein beta-barrel + Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site + Peptidase S24, LexA-like + Flavodoxin, conserved site + Nuclease associated modular domain 3 + RNA polymerase Rpb1, domain 4 + SecA conserved site + Metal-dependent hydrolase HDOD + Phosphoribulokinase/uridine kinase + Transcription-repair-coupling factor, C-terminal domain + Redoxin + Diaminopimelate decarboxylase, LysA + PhoH-like protein + Protein Iojap/ribosomal silencing factor RsfS + AP endonuclease 1 + Homing endonuclease, LAGLIDADG + Leu/Phe/Val dehydrogenases active site + Membrane transport protein + Tryptophan synthase, alpha chain + DNA recombination RmuC + SbsA, Ig-like domain + Protein of unknown function DUF583 + Nucleoside-triphosphatase, THEP1 type + DNA polymerase III, subunit gamma/ tau + Glutamate-tRNA ligase, bacterial/mitochondrial + Solute carrier family 13 + GH3 family + SAM-dependent methyltransferase RsmB/NOP2-type + Uncharacterised protein family UPF0145 + Ribonuclease III + GTP-binding protein, middle domain + Peptidase M16, zinc-binding site + Ribosomal protein L25, long-form + Zinc finger, DksA/TraR C4-type conserved site + Cell division protein FtsZ, conserved site + N-acetylneuraminic acid synthase, N-terminal + NDUFAF3/Mth938 domain-containing protein + Ribosomal protein L35 + Chloride channel, voltage gated + Sulfur carrier protein FdhD + Sec-independent periplasmic protein translocase TatC + Archease domain + Malate/L-lactate dehydrogenase-like + Ribosomal protein S4, bacterial-type + Aspartate kinase domain + Aspartic peptidase, active site + 5'-Nucleotidase/apyrase + RNA polymerase sigma factor 70, region 1.1 + FMN-binding + Methylene-tetrahydrofolate reductase C-terminal + tRNA pseudouridylate synthase B, C-terminal + Flavodoxin/nitric oxide synthase + Nitrite/sulphite reductase 4Fe-4S domain + GAD domain + Zinc/iron permease + GTPase Der, C-terminal KH-domain-like + Transcription elongation factor, GreA/GreB, conserved site + Xaa-Pro dipeptidyl-peptidase-like domain + NADH-quinone oxidoreductase subunit E-like + Pyruvate kinase + Flavin transferase ApbE + D-alanine--D-alanine ligase/VANA/B/C, conserved site + tRNA(Ile)-lysidine synthase, N-terminal + Ribosomal S11, conserved site + SsrA-binding protein, conserved site + RNA (C5-cytosine) methyltransferase + Schiff base-forming aldolase, conserved site + SAM-dependent chlorinase/fluorinase + AAA C-terminal domain + Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB) domain + Translation elongation factor Ts, conserved site + TadE-like + WD40 repeat, conserved site + 30S ribosomal protein S17 + RTX secretion protein D, Gram-negative bacteria + DNA mismatch repair protein MutS, clamp + Methylated-DNA-[protein]-cysteine S-methyltransferase, active site + Cell division protein FtsZ + Zinc-finger, NAD-dependent DNA ligase C4-type + RNA-binding protein AU-1/Ribonuclease E/G + Periplasmic solute binding protein, ZnuA-like + Fagellar hook-basal body protein, FlgE/F/G + Chromosomal replication control, initiator DnaA + Pyridine nucleotide-disulphide oxidoreductase, class-II, active site + Adenylosuccinate synthase, GTP-binding site + Mandelate racemase/muconate lactonizing enzyme, conserved site + Adenylate kinase subfamily + DNA recombination protein RecR + Putative RNA methylase domain + Tyrosine kinase, G-rich domain + Phage capsid + Cell envelope-related transcriptional attenuator domain + Peptidase C69, dipeptidase A + Phosphohydrolase-associated domain + Exonuclease VII, large subunit, C-terminal + RNA 2',3'-cyclic phosphodiesterase + Acetolactate synthase, small subunit, C-terminal + Ribosomal protein S10, conserved site + Anion-transporting ATPase-like domain + Glycosyltransferase family 28, N-terminal domain + Acetolactate synthase, small subunit + Ribosomal RNA methyltransferase FtsJ domain + Potassium uptake protein TrkA + Amidase, conserved site + Phosphoribosyl-AMP cyclohydrolase domain + Hydantoinaseoxoprolinase, N-terminal + Hypoxanthine phosphoribosyl transferase + Tetracycline resistance protein TetA/multidrug resistance protein MdtG + Peptidase C1A, papain C-terminal + Wzt, C-terminal + EcoEI R protein C-terminal domain + Transcription regulator LexA + Luciferase-like domain + Adenine deaminase C-terminal domain + Domain of unknown function DUF4338 + HPr(Ser) kinase/phosphorylase, N-terminal domain-like + Beta-Casp domain + DEAD/DEAH-box helicase, putative + Proteasome, subunit alpha/beta + UbiB domain + Glucosamine/galactosamine-6-phosphate isomerase + Molybdopterin oxidoreductase, molybdopterin cofactor binding site + Ribosomal protein L15, conserved site + DNA alkylation repair enzyme + Rod shape-determining protein MreC + Ribosome recycling factor + Holliday junction DNA helicase RuvA, C-terminal + tRNA (guanine-N1-)-methyltransferase, bacteria + Rubredoxin domain + Sortase domain + Phosphoglucose isomerase (PGI) + DNA-directed DNA polymerase, family A, conserved site + D-alanine--D-alanine ligase, N-terminal domain + GTP-binding protein LepA, C-terminal + 4-hydroxy-tetrahydrodipicolinate synthase, DapA + Peptidase A24A, N-terminal + Fatty acid desaturase domain + 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase + Serpin domain + Peptidase S16, active site + DNA-directed RNA polymerase, alpha subunit + Dienelactone hydrolase + Imidazoleglycerol-phosphate dehydratase, conserved site + Trigger factor + Diacylglycerol kinase, catalytic domain + Sodium-dependent phosphate transport protein + Serine hydroxymethyltransferase, pyridoxal phosphate binding site + DSBA-like thioredoxin domain + Signal transduction histidine kinase, internal region + DNA polymerase III, delta subunit + Desulfoferrodoxin, ferrous iron-binding domain + N-(5'phosphoribosyl) anthranilate isomerase (PRAI) + Primosomal protein N' + Molybdenum cofactor synthesis C-terminal + Peptidase, FtsH + AmmeMemoRadiSam system protein A + Threonine synthase-like + Translation elongation factor P + Chaperonin GroES, conserved site + Deoxyxylulose-5-phosphate synthase + Bile acid:sodium symporter/arsenical resistance protein Acr3 + RNA polymerase sigma factor 70, ECF, conserved site + HpaB/PvcC/4-BUDH C-terminal + Transcriptional regulator MarR-type, conserved site + Ribosomal protein L35, non-mitochondrial + Ribosomal RNA small subunit methyltransferase E + Pilus retraction protein PilT + Mg2+ transporter protein, CorA-like/Zinc transport protein ZntB + Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site + Protein of unknown function DUF3604 + ATP synthase, F0 complex, subunit A, active site + Peptidase U32 + Large ribosomal RNA subunit accumulation protein YceD + CoA enzyme activase, domain of unknown function DUF2229 + GTPase HflX + Protein-tyrosine phosphatase-like + Translation elongation factor P/YeiP, conserved site + Lysidine-tRNA(Ile) synthetase, C-terminal + MnmE, helical domain + TRAP transporter, 4TM/12TM fusion protein + Sel1-like repeat + Transcription termination factor NusA + Gingipain propeptide + C-terminal-processing peptidase S41A + Glutamate synthase, alpha subunit, C-terminal + Conserved hypothetical protein CHP02688 + Preprotein translocase YajC + N-acetylmuramoyl-L-alanine amidase domain + Translation elongation factor EFTs/EF1B + Domain of unknown function DUF4131 + Rhs repeat-associated core + Tryptophan synthase, beta chain, conserved site + CRISPR-associated protein Cas1 + Protein of unknown function DUF3800 + Ribosomal RNA adenine dimethylase + Dehydroquinase, class II + 3-phosphoshikimate 1-carboxyvinyltransferase, conserved site + DNA translocase FtsK, 4TM region + Mannose-6-phosphate isomerase, type II, C-terminal + Coagulation factor 5/8 C-terminal domain + Ribosomal protein L6, conserved site + Exopolysaccharide synthesis protein + Ankyrin repeat + Pseudouridine synthase I, TruA + Chaperone tailless complex polypeptide 1 (TCP-1) + Glycoside hydrolase family 57, N-terminal domain + Phosphopantetheine-protein transferase domain + Group II intron, maturase-specific + Ribonuclease H domain + DNA mismatch repair, conserved site + Phosphoribosylglycinamide formyltransferase, active site + Hydantoinase B/oxoprolinase + PSP1, C-terminal + Glyceraldehyde-3-phosphate dehydrogenase, type I + Glycoside hydrolase, family 4 + Adenylosuccinate lyase C-terminal + Probable transposase, IS891/IS1136/IS1341 + GidA associated domain 3 + Multiple antibiotic resistance (MarC)-related + Transketolase binding site + Peptidase S11, D-alanyl-D-alanine carboxypeptidase A, N-terminal + Domain of unknown function DUF1524 + ATP-grasp fold, RimK-type + Alkylhydroperoxidase AhpD core + Acetyl-CoA hydrolase/transferase + Acetyl-CoA carboxylase carboxyl transferase, beta subunit + Protein MM3350-like domain + Ribosomal protein S3, conserved site + MCM domain + Phenol hydroxylase reductase + FemABX peptidyl transferase + Ada-like domain + ThuA-like domain + KDPG/KHG aldolase + MOFRL-associated domain + Ribosomal protein S5, bacterial-type + Phosphoribosylformylglycinamidine synthase subunit PurS + Carbamoyl-phosphate synthase small subunit, N-terminal domain + Magnesium transporter, MgtE intracellular domain + Glycyl-tRNA synthetase + TRAP transporter solute receptor, DctP family + Endoribonuclease YbeY, conserved site + Penicillin/GL-7-ACA/AHL/aculeacin-A acylase + Sortase family + Ribosomal protein S11, bacterial-type + Uncharacterised protein, DhaK domain + Carbohydrate kinase, predicted, conserved site + 1-deoxy-D-xylulose 5-phosphate reductoisomerase, N-terminal + CobB/CobQ-like glutamine amidotransferase + Initiation factor 2B alpha/beta/delta + Peptidase M17, leucine aminopeptidase/peptidase B + DXP reductoisomerase C-terminal domain + SAICAR synthetase, conserved site + Uroporphiryn-III C-methyltransferase, conserved site + FeS cluster biogenesis + Leu/Ile/Val-binding protein + Putative phosphate transport regulator + Ribosomal protein L24/L26, conserved site + Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site + Guanylate kinase + Peptidase S9A, N-terminal domain + Co-chaperone DjlA, N-terminal + NAD-dependent DNA ligase, conserved site + Ribosomal protein L27, conserved site + DNA primase, DnaG + Virulence factor BrkB + Chorismate mutase + ABC-type glycine betaine transport system, substrate-binding domain + Lumazine synthase + Ribonuclease toxin, BrnT, of type II toxin-antitoxin system + rRNA small subunit methyltransferase I + Exosortase/Archaeosortase domain + Starch synthase, catalytic domain + Homocysteine biosynthesis enzyme, sulfur-incorporation + Glycosyl transferase, family 35 + Alpha-L-fucosidase, metazoa-type + Hydrogenase expression/formation protein, HupF/HypC + GTP cyclohydrolase I, conserved site + Phenylalanyl-tRNA synthetase, class IIc, alpha subunit + Hydrogenase nickel incorporation protein HypA/HybF + Pyrroline-5-carboxylate reductase + Sodium:neurotransmitter symporter + Ribosomal protein S4, conserved site + Glycine-tRNA ligase, alpha subunit + Bacterial DNA recombination protein RuvA + Exosortase EpsH-related + Inositol monophosphatase, conserved site + Deoxynucleoside kinase domain + Flagellar basal body rod protein, conserved site + MTH1187/YkoF-like + Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase + Carboxylase, conserved domain + DNA polymerase, palm domain + Zinc finger, HypF-type + Endonuclease NucS + DoxX family + Nitrite/Sulfite reductase ferredoxin-like domain + Putative membrane protein insertion efficiency factor + GMP synthase, glutamine amidotransferase + DNA helicase, Holliday junction RuvB type + S-adenosyl-l-methionine hydroxide adenosyltransferase, C-terminal + tRNA pseudouridine synthase II, TruB + SMP-30/Gluconolactonase/LRE-like region + Histidine-tRNA ligase + Endopeptidase, NLPC/P60 domain + Dihydrodipicolinate reductase + Putative outer membrane lipoprotein-sorting protein + L-fucose isomerase, C-terminal + RagB/SusD domain + SD-repeat containing protein, B domain + Phosphoesterase, HXTX + Riboflavin biosynthesis protein RibD + Methionyl-tRNA formyltransferase + Metallophosphoesterase, YmdB-like + PdxA family + Xanthine/uracil/vitamin C permease + Chromosome segregation/condensation protein ScpB + Glycoside hydrolase, family 65, N-terminal + tRNA-specific 2-thiouridylase + Protein translocase subunit SecD + Domain of unknown function DUF4065 + Plasmid pRiA4b, Orf3 + Peptide methionine sulphoxide reductase MrsB + Dipeptidylpeptidase IV, N-terminal domain + Aromatic amino acid lyase + Ribosomal protein L1, bacterial-type + Ribosomal protein L32p + Peptidase S58, DmpA + AMMECR1 + Ribosomal protein S17, conserved site + Fibronectin type III + Mrp, conserved site + CocE/Serine esterase + Phosphoglycerate/bisphosphoglycerate mutase, active site + DNA ligase, ATP-dependent, central + Rubredoxin, iron-binding site + Glycine cleavage system H-protein, subgroup + NolW-like + Exonuclease VII, small subunit + RNA polymerase sigma factor 54 + Acyltransferase 3 + Phosphoglycerate kinase, conserved site + Ribosomal protein L30, ferredoxin-like fold domain + Protein-export membrane protein SecF, bacterial + Protein of unknown function DUF1468 + Molybdopterin biosynthesis MoaE + P-type ATPase, subfamily IB + Peptidase M15A, C-terminal + Protein-(glutamine-N5) methyltransferase, release factor-specific + Small GTPase superfamily + Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, B subunit + Ribosomal protein L5, conserved site + Sec-independent protein translocase protein TatA/E + CobN/magnesium chelatase + Argininosuccinate lyase, C-terminal + Recombination protein RecR, conserved site + Endonuclease V + ATP synthase, F0 complex, subunit C, DCCD-binding site + Uncharacterised protein family UPF0434/Trm112 + BPG-independent PGAM, N-terminal + Holo-[acyl carrier protein] synthase + Phosphodiesterase MJ0936/Vps29 + Domain of unknown function DUF3883 + 1-deoxy-D-xylulose 5-phosphate reductoisomerase, C-terminal + Mce/MlaD + Septum formation initiator FtsL/DivIC + Transposase IS30-like HTH domain + DNA polymerase beta, thumb domain + ATP-dependent helicase, C-terminal + FMN-dependent dehydrogenase + Glutathione-dependent formaldehyde-activating enzyme/centromere protein V + Cysteine-tRNA ligase + HAD-superfamily hydrolase,subfamily IIIA + Alpha-L-rhamnosidase RhaM + Ribosome-binding factor A, conserved site + Dihydrodipicolinate reductase, conserved site + Protein of unknown function DUF488 + MOFRL domain + Queuosine biosynthesis protein QueC + Chorismate mutase, type II + Phosphoribosylglycinamide synthetase, conserved site + Histidine triad, conserved site + Nitrogen regulatory protein PII, conserved site + Protein of unknown function DUF2723 + Ribosomal protein S5, N-terminal, conserved site + DNA primase/polymerase, bifunctional, N-terminal + (Uracil-5)-methyltransferase family + Domain of unknown function DUF2007 + Toxin-antitoxin system, antidote protein, HigA + TonB-dependent outer membrane protein SusC/RagA, conserved site + MnmG-related, conserved site + CheC-like domain + RNA 2-O ribose methyltransferase, substrate binding + Transglycosylase SLT domain 2 + Glycoside hydrolase family 38, central domain + DNA helicase, DnaB type + Uncharacterised protein family UPF0251 + Major facilitator, sugar transporter-like + ATPase, V0 complex, c/d subunit + ABC transporter permease MalE + RNA polymerase Rpb2, OB-fold + EVE domain + Cysteine synthase/cystathionine beta-synthase, pyridoxal-phosphate attachment site + Ribonuclease PH, bacterial-type + Aspartate racemase + Sigma 54 modulation/S30EA ribosomal protein, C-terminal + Polyribonucleotide nucleotidyltransferase + Glucose-methanol-choline oxidoreductase, C-terminal + RNA polymerase sigma factor 54, DNA-binding + Homoserine dehydrogenase, conserved site + Transposase, Rhodopirellula-type + Restriction endonuclease, type I, HsdR + Ketopantoate reductase, N-terminal domain + Serine dehydratase-like, alpha subunit + Chaperone protein Skp + Glycosyl transferase, family 20 + Nicotinate/nicotinamide nucleotide adenylyltransferase + Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase-like + Deoxyribose-phosphate aldolase + OB-fold nucleic acid binding domain + Diaminopimelate epimerase, active site + Argininosuccinate lyase + Terminase, large subunit gp17-like + Ribosomal protein L28/L24 + RDD + ATPase domain + Anthranilate synthase/para-aminobenzoate synthase like domain + Transcription regulator Rrf2-type, conserved site + Ribonucleotide reductase regulator NrdR-like + Ribosomal protein L13, conserved site + DDE domain + Prephenate dehydratase, conserved site + Ribosomal protein L3, conserved site + Cytochrome c oxidase, subunit III, 4-helical bundle + Citrate synthase-like, small alpha subdomain + RidA family + Ribosomal protein S14 + Peptidase S49, serine-peptidase prokaryotes + Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain + S-adenosylmethionine synthetase + Phosphoribosyl pyrophosphate synthetase, conserved site + 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate + UvrABC system, subunit C + Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site + RNA polymerase subunit, RPB6/omega + Homoaconitase/3-isopropylmalate dehydratase, large subunit + Glycosyl transferase WecB/TagA/CpsF + Glycosyl transferase, family 19 + Peptidase M17, leucyl aminopeptidase, N-terminal + Phospholipid biosynthesis protein, PlsX-like + V-type ATPase, V0 complex, 116kDa subunit family + GTP-binding protein TrmE, N-terminal + Aspartate decarboxylase + Cytidylate kinase + RNA methyltransferase, RsmD + Ketol-acid reductoisomerase + Domain of unknown function DUF218 + ATPase, V1 complex, subunit D + MCP methyltransferase, CheR-type, SAM-binding domain, C-terminal + Guanylate kinase, conserved site + Myo-inositol-1-phosphate synthase, GAPDH-like + Dihydropteroate synthase + Radical SAM, C-terminal extension + Riboflavin kinase, bacterial + Putative heavy-metal chelation domain + FG-GAP repeat + N-acetyltransferase RimI/Ard1 + Coenzyme A biosynthesis bifunctional protein CoaBC + VanZ-like + Aminoacyl-tRNA synthetase, class I, anticodon-binding domain, subdomain 1 + Aspartate-tRNA ligase, type 1 + Bacteriophage/Gene transfer agent portal protein + Peptidase S9A, prolyl oligopeptidase + Formate-tetrahydrofolate ligase, FTHFS, conserved site + Ribosomal protein S7, conserved site + Domain of unknown function DUF1616 + Phenylalanine-tRNA ligase, class IIc, beta subunit + Formate/nitrite transporter + Domain of unknown function DUF4349 + Methionyl-tRNA synthetase + FecR protein + Sodium:alanine symporter + Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase + Multi-copper polyphenol oxidoreductase + Sulfotransferase + Phosphoribosylglycinamide synthetase + Coenzyme PQQ synthesis D + Putative F0F1-ATPase subunit, Ca2+/Mg2+ transporter + Flavoprotein pyridine nucleotide cytochrome reductase + Zinc-finger binding domain of transposase IS66 + BON domain + UvrABC system subunit A + Nicotinate-nucleotide pyrophosphorylase + Lumazine-binding protein + Segregation and condensation protein A + S-adenosylmethionine-dependent methyltransferase + NAD-dependent DNA ligase, active site + tRNA-dihydrouridine synthase, conserved site + Peptidase S8 propeptide/proteinase inhibitor I9 + F1F0 ATP synthase OSCP/delta subunit, N-terminal domain + Pyridoxal phosphate-dependent decarboxylase + Succinylglutamate desuccinylase/aspartoacylase + Ferrous iron transport protein B + Lipid/polyisoprenoid-binding, YceI-like + Ribose 5-phosphate isomerase B + V-type ATPase subunit c domain + Domain of unknown function DUF523 + Intein C-terminal splicing region + NAD-dependent DNA ligase + Biotin protein ligase, C-terminal + tRNA-guanine transglycosylase + Epoxide hydrolase-like + GTP-binding protein EngA + Ribosomal protein L19, conserved site + ATP-citrate lyase/succinyl-CoA ligase, active site + CHAT domain + Aconitase X catalytic domain, putative + Diphthamide synthase domain + Heavy-metal-associated, conserved site + Ribonuclease P, conserved site + EF-hand domain + MgtC/SapB/SrpB/YhiD family + Toxin HigB-like + DNA polymerase III epsilon subunit, exonuclease domain + RNA 3'-terminal phosphate cyclase domain + Protein of unknown function DUF2961 + Leucine rich repeat 4 + Putative Flp pilus-assembly TadG-like, N-terminal + Transposase zinc-binding domain + GTP-binding protein Obg/CgtA + Glucose-methanol-choline oxidoreductase, N-terminal + Organic solvent tolerance-like, N-terminal + S-layer homology domain + Protein of unknown function DUF503 + Protein of unknown function DUF1016 + Anthranilate phosphoribosyl transferase + Phosphocarrier protein HPr-like + Acetylglutamate kinase + Thymidylate kinase, conserved site + Lon protease, bacterial/eukaryotic-type + Glycosyltransferase family 87 + Competence protein ComEA, helix-hairpin-helix domain + THUMP domain + Exonuclease VII, large subunit + Transcriptional regulator MraZ + DNA topoisomerase I, bacterial-type + DNA-binding, RecF, conserved site + Queuosine precursor transporter + Surface presentation of antigen (SpoA) + Endonuclease III, iron-sulphur binding site + Immunoprotective extracellular, immunoglobulin-like domain + D-galactarate/Altronate dehydratase, C-terminal + Peptidase M41, FtsH extracellular + Delta-aminolevulinic acid dehydratase + UDP-3-O-acyl N-acetylglucosamine deacetylase + HAD-superfamily hydrolase, subfamily IIA + MCP methyltransferase, CheR-type + Translation initiation factor 3, conserved site + Phosphotransferase system, enzyme I N-terminal + Xaa-Pro dipeptidyl-peptidase, C-terminal + Gliding motility-associated, C-terminal domain + GTP cyclohydrolase 1 type 2/Nif3 + Orotidine 5'-phosphate decarboxylase, active site + Intein + Protein of unknown function DUF1385 + PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase + Adenosylcobinamide-GDP ribazoletransferase + Chaperone DnaJ + Translation elongation factor EFTu/EF1A, bacterial/organelle + Tetrapyrrole biosynthesis, uroporphyrinogen III synthase + Transposase, zinc-ribbon + CTP synthase + Orn/DAP/Arg decarboxylase 2, pyridoxal-phosphate binding site + Lactate/malate dehydrogenase, C-terminal + Hydrogenase accessory protein HypB + DNA polymerase beta-like, N-terminal domain + Domain of unknown function DUF304 + Protein of unknown function DUF2298 + Dehydroquinase, class II, conserved site + Domain of unknown function DUF2341 + Signal-recognition particle receptor FtsY + N-acetyl-gamma-glutamyl-phosphate reductase, type 1 + 16S rRNA processing protein RimM + XdhC Rossmann domain + AP endonuclease 1, binding site + tRNA N6-adenosine threonylcarbamoyltransferase, TsaD + Domain of unknown function DUF1156 + Chaperone DnaK + DNA helicase, ATP-dependent, RecQ type + Cobalamin biosynthesis CobD/CbiB + Domain of unknown function DUF2344 + Adenylosuccinate lyase + Radical-activating enzyme, conserved site + RimM protein + Bacteriophage lambda, GpA + Ppx/GppA phosphatase + DNA methylase, C-5 cytosine-specific, conserved site + dNTP triphosphohydrolase + Ribosomal protein L30, bacterial-type + Tetraacyldisaccharide 4'-kinase + C-type lectin-like/link domain + Desulforodoxin domain + Phospho-N-acetylmuramoyl-pentapeptide transferase + Restriction system protein Mrr-like N-terminal domain + DNA integrity scanning protein, DisA, N-terminal + Peptide chain release factor 1 + RNA polymerase sigma factor 54, core-binding + Asp/Glu racemase, active site 1 + Pyridoxal phosphate (active vitamin B6) biosynthesis PdxJ + Protein of unknown function DUF192 + GTP1/OBG, conserved site + Mg chelatase-related protein + Uncharacterised protein family YtxH + TATA-box binding protein + dTDP-4-dehydrorhamnose reductase family + NTP pyrophosphohydrolase MazG + Peptidase M29 + Adenosylcobalamin biosynthesis, ATP:cob(I)alamin adenosyltransferase-like + Glucosamine-fructose-6-phosphate aminotransferase, isomerising + Sugar-binding domain, putative + 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, conserved site + Protein of unknown function DUF2206, membrane + Histidinol dehydrogenase, conserved site + Ureohydrolase, manganese-binding site + Uncharacterised protein family UPF0182 + GTP cyclohydrolase I + Electron transfer flavoprotein subunit alpha, conserved site + Ribosome-binding ATPase YchF/Obg-like ATPase 1 + 4-diphosphocytidyl-2C-methyl-D-erythritol kinase + BCCT transporter family + Group II intron reverse transcriptase/maturase + PglZ domain + Nucleoside diphosphate kinase, active site + Ribonuclease PH, conserved site + ClpP, Ser active site + Phosphoribosylformylglycinamidine cyclo-ligase + 3-deoxy-D-manno-octulosonic-acid transferase, N-terminal + 3-oxoacyl-[acyl-carrier-protein] synthase 2 + Bacterial RecJ exonuclease + Phosphofructokinase, conserved site + Glycoside hydrolase family 31 + Molybdenum cofactor biosynthesis C + Glycoside hydrolase family 1 + PIN family, putative toxin-antitoxin system toxin component + Lactate/malate dehydrogenase, N-terminal + Protein of unknown function DUF1573 + Pyridoxamine kinase/Phosphomethylpyrimidine kinase + dTDP-glucose 4,6-dehydratase + UDP-N-acetylenolpyruvoylglucosamine reductase + GTP-binding protein Era + Alpha-glucan phosphorylase + Arsenate reductase-like + Imidazole glycerol phosphate synthase, subunit H + GyrI-like small molecule binding domain + Peptidase S11, D-alanyl-D-alanine carboxypeptidase A + HemN, C-terminal + Homoaconitase/3-isopropylmalate dehydratase, large subunit, prokaryotic + Kelch repeat type 1 + tRNA-dihydrouridine synthase, putative, C-terminal + Transcription antitermination protein, NusG, bacteria, conserved site + UDP-N-acetylmuramoylalanine-D-glutamate ligase + Ketopantoate reductase, C-terminal domain + Phosphatidate cytidylyltransferase + Autophagy-related protein 22-like + ATP synthase, F1 complex, delta/epsilon subunit + DNA polymerase type-Y, HhH motif + Uncharacterised protein family YfhO + Transcription elongation factor GreA + Ribonucleotide reductase, adenosylcobalamin-dependent + Sulphate adenylyltransferase catalytic domain + Peptidase S49, SppA + CCB3/YggT + GHMP kinase, ATP-binding, conserved site + Dna2/Cas4, domain of unknown function DUF83 + Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain + Cobinamide kinase/cobinamide phosphate guanyltransferase + Herpesvirus/Caudovirus protease domain + Transcription termination factor Rho + Fructose-1,6-bisphosphatase, class V + Selenophosphate synthetase + Na+/H+ antiporter, NhaC-like, C-terminal + L-seryl-tRNA selenium transferase-like + ATP-dependent DNA helicase RecQ, zinc-binding domain + GtrA-like protein + Prolyl-tRNA synthetase, class IIa, bacterial-type + Transposase, putative, helix-turn-helix domain + Aerotolerance regulator, N-terminal + Type IX secretion system membrane protein, PorP/SprF family + Histidinol-phosphate aminotransferase family + PdxS/SNZ N-terminal domain + Archaeal PaREP1 + Organic radical enzyme activase + Uridylate kinase, bacteria + YerB-like + Uncharacterised protein GYD + Zinc finger C2H2-type + DRTGG + YD repeat + Succinate dehydogenase/fumarate reductase N-terminal + Peptidase M6-like, domain + 3-oxoacyl-(acyl-carrier-protein) reductase + YVTN beta-propeller repeat + ATP synthase, F0 complex, subunit C, bacterial/chloroplast + Peptide chain release factor 2 + Glutamine synthetase, N-terminal conserved site + DNA repair protein RadA + Histidine kinase, N-terminal 7TM region + Riboflavin-specific deaminase, C-terminal + Hydroxymethylglutaryl-CoA reductase, class I/II + Phosphoribosyl-ATP pyrophosphohydrolase-like + Cytochrome P450 + Tryptophan synthase, alpha chain, active site + Alpha-L-rhamnosidase, six-hairpin glycosidase domain + Adenosine/AMP deaminase domain + Putative small multi-drug export + Cytokinin riboside 5'-monophosphate phosphoribohydrolase LOG + Protein of unknown function DUF4870 + RNA polymerase, subunit omega/K/RPB6 + LexA-binding, inner membrane-associated putative hydrolase + Alanine racemase, pyridoxal-phosphate attachment site + Ribosomal protein L11, conserved site + Fatty acid hydroxylase + Membrane insertase YidC, N-terminal + ATP synthase, F1 complex, beta subunit + Prokaryotic transglycosylase, active site + Glutamate 5-kinase, conserved site + PBS lyase HEAT-like repeat + Virulence protein RhuM-like + Cell cycle, FtsW / RodA / SpoVE, conserved site + LarC/UPF0272 + Glycoside hydrolase, family 13, N-terminal + SagB-type dehydrogenase domain + C4-type zinc ribbon domain + 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, conserved site + Ribosomal protein S14, conserved site + ATPase, V1 complex, subunit F + Indole-3-glycerol phosphate synthase, conserved site + Dodecin-like + DAGK family + BlaI transcriptional regulatory family + UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, non-repeat region + Alkaline shock protein Asp23 + Phage shock protein, PspC, N-terminal + Lysine-tRNA ligase, class II + Glycosyl hydrolase family 92 + Methylthioribose-1-phosphate isomerase + Yip1 domain + UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase + ATPsynthase alpha/beta subunit, N-terminal extension + UDP-3-O-acyl N-acetylglucosamine deacetylase, C-terminal + 3-hydroxyacyl-CoA dehydrogenase, conserved site + Na+/H+ antiporter subunit E + Domain of unknown function DUF448 + Dihydrolipoamide dehydrogenase + Zinc finger, ClpX C4-type + Ribosomal protein L28 + Purple acid phosphatase, N-terminal + Uncharacterised protein family HicB + IPT domain + PASTA domain + CDP-glycerol glycerophosphotransferase + SusD-like, N-terminal + Carbonic anhydrase + Phosphatidylethanolamine-binding protein + Winged helix-turn helix domain + Pilus assembly protein, PilO + Thiamine-monophosphate kinase + Transcription regulator, HTH DeoR-type, conserved site + Histidine biosynthesis, HisF + Virulence-associated protein D / CRISPR associated protein Cas2 + Adenylosuccinate synthase, active site + Acetyl xylan esterase + Type II secretion system protein G + Hydrogenase expression/formation protein HypE + Mitochondrial biogenesis protein AIM24 + Type II secretion system conserved site + Outer membrane protein transport protein (OMPP1/FadL/TodX) + Dodecin + Na(+)/H(+) antiporter subunit F-like + Thioredoxin reductase + Galactokinase galactose-binding domain + Crossover junction endodeoxyribonuclease RuvC, magnesium-binding site + Transposase IS66, Orf2 + Phage tail tape measure protein + Galactokinase/homoserine kinase + Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase, N-terminal + Pyridoxal 5'-phosphate synthase subunit PdxT/SNO + RelA/SpoT family + Proteinase inhibitor I42, chagasin + L-asparaginase, N-terminal + Uncharacterised hydrolase TatD-type + Thiamine-binding protein + Branched-chain amino acid aminotransferase I + Glutamate-ammonia ligase adenylyltransferase, repeated domain + Cyclodeaminase/cyclohydrolase + 3D domain + Ccc1 family + ATP-grasp fold, DUF201-type + Gamma-glutamyl phosphate reductase GPR, conserved site + Phenazine biosynthesis PhzF protein + Protein of unknown function DUF499 + Helix-turn-helix, HxlR type + Tex-like domain + Porphobilinogen deaminase, N-terminal + DNA mismatch repair protein family + CRISPR-associated endonuclease Cas2 + Peptidase C45 + NADH-ubiquinone oxidoreductase, 20 Kd subunit + CRISPR type III-associated RAMP protein + ATP synthase, F1 complex, gamma subunit conserved site + Glycosyl hydrolase family 32, N-terminal + Protein of unknown function DUF721/UPF0232 + Transmembrane secretion effector + Heparin-sulfate lyase, N-terminal + Thiamine phosphate synthase + Succinyl-CoA synthetase, beta subunit, conserved site + Methyladenine glycosylase + Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase, C-terminal + DNA polymerase 1 + Geranylgeranyl reductase family + Formamidopyrimidine-DNA glycosylase + NADH:ubiquinone oxidoreductase, subunit 1, conserved site + DNA-binding transcriptional activator AlpA + FAS1 domain + DinB-like domain + UvrABC system, subunit B + Sortilin, N-terminal + Fimbrial assembly PilN + Na+/H+ antiporter subunit G + POTRA domain, FtsQ-type + Protein of unknown function DUF2851 + Ammonium transporter, conserved site + Phosphate transport system protein PhoU + Sialate O-acetylesterase domain + Transcriptional regulator, AbiEi antitoxin + Type III secretion system FHIPEP + Alpha-2-macroglobulin + Phosphatidylserine decarboxylase-related + Malonyl CoA-acyl carrier protein transacylase, FabD-type + DEAD box helicase DbpA/CsdA, RNA-binding domain + Ribonuclease Y + 3-hydroxyisobutyrate dehydrogenase-related, conserved site + ATP synthase, F1 complex, alpha subunit + YicC-like, N-terminal + AMP-binding + Peptidase M50, putative membrane-associated zinc metallopeptidase + Chemotaxis receptor methyltransferase CheR, N-terminal + Conserved hypothetical protein CHP00275, flavoprotein HI0933-like + Collagen triple helix repeat + Cytochrome c oxidase, subunit I, copper-binding site + SIMIBI class G3E GTPase, ArgK/MeaB + 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase + Di-haem cytochrome c peroxidase + ATP-sulfurylase PUA-like domain + UbiE/COQ5 methyltransferase, conserved site + Probable zinc-binding domain + Alpha-2-macroglobulin, N-terminal + Sirohaem synthase, N-terminal + Domain of unknown function DUF5060 + Daunorubicin resistance ABC transporter ATP-binding subunit DrrA + LPPG:FO 2-phospho-L-lactate transferase CofD/UPF0052 + Endonuclease III-like, conserved site-2 + Formate dehydrogenase, alpha subunit + Thil, AANH domain + D-alanine--D-alanine ligase + ABC transporter, substrate-binding protein + CCA-adding enzyme, C-terminal + N-acetyl-gamma-glutamyl-phosphate reductase, active site + Haemerythrin-like + Domain of unknown function DUF302 + Acetyl-CoA biotin carboxyl carrier + Cytochrome c oxidase-like subunit III + GTP cyclohydrolase II, RibA + DNA glycosylase/AP lyase, zinc finger domain, DNA-binding site + Protein of unknown function DUF1232 + Domain of unknown function DUF4040 + Protein of unknown function DUF1566 + PPC domain + Fic/DOC N-terminal + Acetyl-CoA carboxylase, alpha subunit + Type III secretion system substrate exporter + UDP-N-acetylglucosamine 1-carboxyvinyltransferase + XdhC- CoxI + Uncharacterised protein family UPF0261 + Opine dehydrogenase + Protein of unknown function DUF885 + SAP domain + Polyketide cyclase/dehydrase + IMP dehydrogenase / GMP reductase, conserved site + Shikimate dehydrogenase + Acetolactate synthase, large subunit, biosynthetic + Galactose-1-phosphate uridyl transferase, N-terminal + Nitrogen regulatory protein P-II, urydylation site + AsmA-like, C-terminal + Na+/H+ antiporter MnhB subunit-related protein + CYTH domain + Beta-galactosidase trimerisation + ClpP, histidine active site + L-lactate/malate dehydrogenase + Trehalose-phosphatase + Thymidine kinase + Dihydroorotase + Octanoyltransferase + Methylmalonyl-CoA epimerase + tRNA-specific adenosine deaminase + Urocanase, Rossmann-like domain + 5-formyltetrahydrofolate cyclo-ligase + Fibronectin type III-like domain + ATP-citrate lyase/succinyl-CoA ligase, conserved site + UDP-N-acetylmuramate--L-alanine ligase + Peptidase M29, N-terminal + Regulator of chromosome condensation, RCC1 + Protein-tyrosine phosphatase, low molecular weight + Octanoyltransferase, conserved site + tRNA (guanine-N-7) methyltransferase, Trmb type + Bacteriophage/plasmid primase, P4, C-terminal + Toxin HigB-1 + Protein of unknown function DUF1501 + Udp N-acetylglucosamine O-acyltransferase, C-terminal + Lipopolysaccharide kinase + AMIN domain + RNA-directed DNA polymerase (reverse transcriptase), msDNA + ABC transporter Uup, C-terminal + Uncharacterised protein family UPF0236 + Curli production assembly/transport component CsgG + Type IV secretion system coupling protein TraD, DNA-binding domain + Aldose 1-/Glucose-6-phosphate 1-epimerase + RNA methyltransferase TrmA, active site + Roadblock/LAMTOR2 domain + Tryptophan synthase, beta chain + Large-conductance mechanosensitive channel + Pyrimidine nucleoside phosphorylase, C-terminal + Shikimate kinase, conserved site + Protein of unknown function DUF763 + RsgA GTPase domain + 3-oxoacyl-[acyl-carrier-protein] synthase 3 + Zincin-like metallopeptidase + Signal transduction response regulator, chemotaxis, protein-glutamate methylesterase + G-protein beta WD-40 repeat + NrfD family + AF2212-like domain + CO dehydrogenase/acetyl-CoA synthase complex beta subunit + Membrane bound O-acyl transferase, MBOAT + Urocanase, C-terminal domain + Domain of unknown function DUF1732 + Conserved hypothetical protein CHP04076 + NADH:ubiquinone/plastoquinone oxidoreductase, chain 6 + Cyclic nucleotide-binding, conserved site + Transposase IS204/IS1001/IS1096/IS1165, zinc-finger + dCTP deaminase + Domain of unknown function DUF4382 + RQC domain + Bacterial transcriptional activator domain + RNA polymerase sigma factor RpoD, C-terminal + UDP-3-O-acyl N-acetylglucosamine deacetylase, N-terminal + Jag, N-terminal + 6-phosphogluconate dehydrogenase, C-terminal + DNA mismatch endonuclease vsr + ATPase, V1/A1 complex, subunit E + Ribosomal protein L2, conserved site + Twin-arginine translocation protein TatB-like + Glucose/Sorbosone dehydrogenase + HipA-like, C-terminal + DNA-directed RNA polymerase, subunit beta-prime + Outer membrane protein beta-barrel domain + Thiol:disulfide interchange protein DsbD, N-terminal domain + DNA-binding, RecF + Protein of unknown function DUF123 + Transcription regulator TrmB, N-terminal + Cysteine peptidase, cysteine active site + Orotidine 5'-phosphate decarboxylase, type 2 + Domain of unknown function DUF128 + Ethanolamine utilization protein EutN/carboxysome structural protein Ccml + Ferrochelatase + Domain of unknown function DUF4213 + Endonuclease III-like, iron-sulphur cluster loop motif + Heat-inducible transcription repressor HrcA + Succinate dehydrogenase/fumarate reductase type B, transmembrane subunit + Domain of unknown function DUF2520 + NIL domain + RHS repeat + Glycine cleavage system T protein + Adenylyl-sulfate kinase + 3-dehydroquinate synthase AroB + Ribosomal protein L33 + Flavodoxin-like fold + Putative auto-transporter adhesin, head GIN domain + Uncharacterised protein family CoxE-like + 6-phosphogluconate dehydrogenase + 1-deoxy-D-xylulose 5-phosphate reductoisomerase + KAP family P-loop domain + Protein of unknown function DUF1127 + Nuclease-related domain, NERD + S-adenosylmethionine decarboxylase, core + Serpin, conserved site + Urocanase, N-terminal domain + Lipoyl synthase + UDP-glucose 4-epimerase + Phosphate ABC transporter, permease protein PstC + Glutamyl-tRNA(Gln) amidotransferase A subunit + Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA + Protein of unknown function DUF4838 + Uroporphyrin-III C-methyltransferase + Integral membrane protein 1906 + Conserved TM helix + FeS cluster insertion protein + YutG/PgpA domain + Dual-specificity RNA methyltransferase RlmN + NADH:ubiquinone/plastoquinone oxidoreductase, chain 3 + Methane oxygenase PmoA + DNA primase, phage/plasmid + Glycoside hydrolase family 20, catalytic domain + Phosphotransferase system, HPr histidine phosphorylation site + Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B + Formylmethanofuran dehydrogenase, subunit E domain + Aspartate-semialdehyde dehydrogenase, conserved site + Aromatic-ring-hydroxylating dioxygenase, alpha subunit, C-terminal domain + Outer membrane lipoprotein carrier protein LolA-like + Aspartate-semialdehyde dehydrogenase, beta-type + DNA-directed DNA polymerase, family B, multifunctional domain + Protein of unknown function DUF2892 + Copper chaperone SCO1/SenC + Carbamoyl-phosphate synthase, small subunit + DnaD-like domain + Galactokinase + Capsule polysaccharide biosynthesis + Porphobilinogen deaminase + Sulfolobus virus STSV1, Orf64 + Protein MutL + RNA-binding protein, predicted + Proline-tRNA ligase, class II, C-terminal + UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase + Protein of unknown function DUF465 + 7Fe ferredoxin + Beta-hexosaminidase, bacteial type, N-terminal + Amidophosphoribosyltransferase + Cysteine synthase + Putative LytR/CpsA/Psr regulator, C-terminal domain + Phosphoribosylformylglycinamidine synthase subunit PurQ + Polyphosphate kinase C-terminal domain + Elongation factor 4 + Helix-turn-helix protein RpiR + Nitrogenase/oxidoreductase, component 1 + TonB-dependent outer membrane protein, SusC/RagA + Crossover junction endodeoxyribonuclease, RusA-like + Domain of unknown function DUF1638 + Ion transport domain + ATP:cob(I)alamin adenosyltransferase, PduO-type + Carbamoyltransferase + AP endonuclease, family 2, C-terminal + Cardiolipin synthase N-terminal + Coproporphyrinogen III oxidase, oxygen-independent related + Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like domain + Hydrogenase assembly chaperone, conserved site + GPR domain + Two component regulator three Y + 5'-Nucleotidase, conserved site + Protein of unknown function DUF917 + Magnesium transporter MgtE + Aerotolerance-related protein BatD + N-formylglutamate amidohydrolase + LPS export ABC transporter, ATP-binding protein LptB + Domain of unknown function DUF1214 + Methylthioadenosine phosphorylase (MTAP) + Protein of unknown function DUF502 + Peptidase M56 + Dihydroneopterin aldolase/epimerase domain + Tubulin, conserved site + Anhydro-N-acetylmuramic acid kinase + Sporulation stage II protein D, amidase enhancer LytB N-terminal + Protein of unknown function DUF1670 + MutY, C-terminal + 3-phosphoshikimate 1-carboxyvinyltransferase + ADP-glucose pyrophosphorylase, conserved site + Cytochrome b/b6-like domain + Metal-dependent phosphohydrolase, 7TM extracellular domain + Monomethylamine methyltransferase MtmB + Orotate phosphoribosyl transferase domain + Intron endonuclease, group I + Glucose-6-phosphate dehydrogenase, C-terminal + Citrate synthase active site + Methionyl-tRNA synthetase, beta subunit, C-terminal + Succinyl-CoA ligase, alpha subunit + DNA mismatch repair protein MutS + Ribosomal protein L10, eubacterial, conserved site + Metal-dependent phosphohydrolase, 7TM intracellular domain + Domain of unknown function DUF4145 + Intramolecular chaperone auto-processing domain + AP endonuclease 2, zinc binding site + Type III secretion system substrate exporter, C-terminal + Peptidase S13, D-Ala-D-Ala carboxypeptidase C + Signal recognition particle protein Ffh + Carbohydrate-binding, CenC-like + Penicillin-binding protein 2 + S-adenosylmethionine decarboxylase family, prokaryotic + Protein of unknown function DUF3048, C-terminal domain + CAAX prenyl protease 1, N-terminal + Ribosomal protein L23/L25, conserved site + Protease PrsW + Glucose-6-phosphate dehydrogenase, NAD-binding + DNA gyrase, subunit B + Helicase HerA-like C-terminal + Molybdenum cofactor biosynthesis protein A + CstA, N-terminal domain + Ribonucleotide reductase small subunit family + Listeria/Bacterioides repeat + Domain of unknown function DUF1730 + Aldo/keto reductase, conserved site + Deoxyuridine triphosphate nucleotidohydrolase + Protein of unknown function DUF2207, membrane + Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ + Domain of unknown function DUF255 + Mycobacterial 4 TMS phage holin, superfamily IV + Purine phosphorylase, family 2, conserved site + Ribosomal protein L35, conserved site + Domain of unknown function DUF4070 + N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine deformylase/Succinyl-diaminopimelate desuccinylase + NADH-quinone oxidoreductase, chain M/4 + GLUG + Domain of unknown function DUF4268 + RNA methyltransferase RlmH + Glycoside hydrolase, family 43 + CxxC-x17-CxxC domain + Intein N-terminal splicing region + Na-Ca exchanger/integrin-beta4 + Pectate lyase superfamily protein + Phosphate transport system permease protein PstA + Cell shape-determining protein MreD + Cyclin-like + Ribulose bisphosphate carboxylase, large subunit, C-terminal + Bacterial antitoxin of type II TA system, VapB + Asparagine synthase, glutamine-hydrolyzing + Phosphoribosylaminoimidazole-succinocarboxamide synthase + ASPIC/UnbV + Translocation and assembly module TamB + Cell division protein ZapA-like + Phosphoglucose isomerase, conserved site + Heat shock protein Hsp90 family + DNA polymerase family X, beta-like + Clp protease, ATP-binding subunit ClpX + Phosphoribosylglycinamide formyltransferase + Domain of unknown function DUF820 + HTH-type transcriptional regulator AraC-type, N-terminal + FAD-dependent glycerol-3-phosphate dehydrogenase + Ribosome biogenesis GTPase RsgA + Histidinol-phosphate phosphatase + Transcription-repair coupling factor + Ribose 5-phosphate isomerase, type A + Phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent + Solute-binding protein family 3, conserved site + Ribosome maturation factor RimP, N-terminal + Protein of unknown function DUF3048, N-terminal + Formiminotransferase, N-terminal subdomain + Probable epoxyqueuosine reductase QueH + Glycoside hydrolase, family 77 + Phosphate-selective porin O/P + Zinc finger, SWIM-type + Reductive dehalogenase domain + ATP-dependent DNA helicase RecG + Outer membrane protein assembly factor BamD + Translin, N-terminal + Lipopolysaccharide assembly, LptC-related + Putative glycohydrolase domain DUF4038 + SOS response associated peptidase (SRAP) + RNA methyltransferase TrmH family + Domain of unknown function DUF4405 + Protein of unknown function DUF401 + Glutamate racemase + GDP-mannose 4,6-dehydratase + Flagellar P-ring protein + Phospho-2-dehydro-3-deoxyheptonate aldolase, subtype 2 + Protein of unknown function DUF3467 + ResB-like domain + Isocitrate dehydrogenase NADP-dependent, monomeric + Motility protein B, N-terminal domain + Pheromone shutdown, TraB + tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG + Glutamate synthase, central-N + Domain of unknown function DUF4159 + Flavin prenyltransferase UbiX/Pad1 + SAM-dependent methyltransferase RsmI, conserved site + Thiosulphate sulfurtransferase, conserved site + Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 + Domain of unknown function DUF4091 + ATP synthase, F0 complex, subunit b, bacterial + Protein of unknown function DUF2924 + PA domain + WbqC-like protein family + Ribosomal protein L34 + Thiazole synthase ThiG + Phospholipase/carboxylesterase/thioesterase + Ribonuclease E/G + ABC-type uncharacterised transport system + Intradiol ring-cleavage dioxygenase, core + Glycoside hydrolase, family 2 + DnaD domain + Peroxide stress protein YaaA + Na/H antiporter domain + Protein of unknown function DUF3108 + YbhB/YbcL + Alpha-2-macroglobulin, N-terminal 2 + Phage terminase large subunit, N-terminal + KilA-N, DNA-binding domain + Transposase TnpC, homeodomain + RapZ-like family + Tex-like protein, N-terminal + NurA domain + Peptidase C26 + RnfC Barrel sandwich hybrid domain + Copper amine oxidase-like, N-terminal + Phosphoribosyl-ATP pyrophosphohydrolase + Neurolysin/Thimet oligopeptidase, N-terminal + Epoxyqueuosine reductase QueG + Peptidase, C-terminal, archaeal/bacterial + Protein of unknown function DUF3368 + Anaerobic ribonucleoside-triphosphate reductase activating protein + Peptidase S9, serine active site + MTH538 TIR-like domain + Protein of unknown function DUF2791 + Glycosyltransferase WbsX + Essential recombination function protein + Domain of unknown function DUF4342 + TonB-dependent receptor, conserved site + Putative transposase IS4/IS5 family + Na+/H+ antiporter NhaA + Lactonase, 7-bladed beta propeller + NAD-glutamate dehydrogenase + Prohead protease + Cytochrome c-type biogenesis protein CcmF, C-terminal + Tagatose-6-phosphate kinase/1-phosphofructokinase N-terminal domain + Organic solvent tolerance protein, C-terminal + Glycoside hydrolase, family 3, active site + Apolipoprotein N-acyltransferase + Pyridoxamine 5'-phosphate oxidase-related + Transcription regulator MerR, DNA binding + Inorganic pyrophosphatase + Putative neutral zinc metallopeptidase + Aconitase X swivel domain, putative + Protein of unknown function DUF917, N-terminal + Three-Cys-motif partner protein + MT-A70-like + BioY protein + Tex protein, YqgF-like domain + Thymidylate synthase + Sodium/solute symporter, conserved site + L-fucose isomerase, N-terminal-1 + Double Cache domain 2 + Orn/DAP/Arg decarboxylase 2, conserved site + ATP synthase delta/epsilon subunit, C-terminal domain + Domain of unknown function DUF814 + Ribosome maturation factor RimP, C-terminal + Protein CR006, P-loop domain + SPFH domain, YdjI-like + Bacterial periplasmic spermidine/putrescine-binding protein + Protein of unknown function DUF4012 + Phosphotransferase system, mannose-type IIA component + ECF transporter, substrate-specific component + RidA, conserved site + Porphobilinogen deaminase, C-terminal + Adaptor protein ClpS, core + NRAMP family + CopG antitoxin + Cytochrome c, class IA/ IB + Cobalamin (vitamin B12) biosynthesis CbiM family + Domain of unknown function DUF2062 + NADH:cytochrome b5 reductase (CBR) + Oligopeptidase F, N-terminal domain + Isoprenylcysteine carboxyl methyltransferase + Alpha-galactosidase, NEW3 domain + Voltage-gated potassium channel + Conserved hypothetical protein CHP00725 + Agmatinase-related + Asparaginase/glutaminase-like + Acyl-CoA thioester hydrolase YbgC/YbaW family + Restriction endonuclease, type II, TdeIII + DsrE2-like family + Arsenical pump ATPase, ArsA/GET3 + Formate/nitrite transporter, conserved site + DNA-directed RNA polymerase, omega subunit + Abortive bacteriophage infection, resistance + Mannonate dehydratase + CRISPR-associated Cas3-HD domain + Metal-sensitive transcriptional repressor + Fumarase C, C-terminal + Dihydroxy-acid dehydratase + Flagellar motor switch protein FliG + Anti-sigma factor antagonist + MiaB-like tRNA modifying enzyme + Penicillin amidase type, domain1 + Domain of unknown function DUF3786 + Protein of unknown function DUF917, C-terminal + Peptidase M32, carboxypeptidase Taq + Histidine kinase CheA-like, homodimeric domain + NADPH-dependent 7-cyano-7-deazaguanine reductase QueF + Glucose-1-phosphate thymidylyltransferase, short form + Protein of unknown function DUF5131 + Glutaredoxin active site + Doubled CXXCH motif + Formiminotransferase, C-terminal subdomain + Protein of unknown function DUF2085, transmembrane + Putative peptidoglycan binding domain + Uncharacterised protein family UPF0066, conserved site + AbiEi antitoxin C-terminal domain + Orotidine 5'-phosphate decarboxylase + Uncharacterised conserved protein UCP016719 + Domain of unknown function DUF1254 + Leucyl/phenylalanyl-tRNA-protein transferase + Cytochrome ubiquinol oxidase subunit 1 + Type IV secretion system protein TraG/VirD4 + Portal protein + GTP cyclohydrolase FolE2/MptA + Pirin, N-terminal domain + Phosphate transport system permease protein 1 + Tex-like protein, HTH domain + Cell division protein FtsQ/DivIB + Glycosyl hydrolase 36, catalytic domain + Next to BRCA1, central domain + Succinate--CoA synthetase, beta subunit + RNA methyltransferase TrmA, conserved site + AP endonuclease 2 + Carbamoyltransferase, HypF-type + DNA sulphur modification protein DndB + AsmA + Protein of unknown function DUF3489 + Electron transfer flavoprotein, beta-subunit, conserved site + LUD domain + Sodium ion-translocating decarboxylase + Ribonuclease R winged-helix domain + DGQHR-containing domain + Uncharacterised protein family UPF0165 + PdxT/SNO family, conserved site + Nitrite/sulphite reductase iron-sulphur/sirohaem-binding site + Putative Ig + Haem-degrading + Glycosyl hydrolase 94 + Cyclic nucleotide-regulated ion channel, N-terminal domain + Signal transduction histidine kinase, subgroup 2, dimerisation and phosphoacceptor domain + DNA ligase, ATP-dependent, C-terminal + Manganese/iron superoxide dismutase, C-terminal + Domain of unknown function DUF1801 + Glycoside hydrolase, family 25 + Thiazole biosynthetic enzyme Thi4 family + 2TM domain + CHASE2 + Domain of unknown function DUF1330 + Domain of unknown function DUF4129 + UbiA prenyltransferase conserved site + SMCs flexible hinge + Peptidase A24A, prepilin type IV, bacterial + Vancomycin resistance VanW + Tricorn protease C1 domain + 5-methylcytosine restriction system component + Phosphotransferase system, enzyme I-like + Peptidase M22, conserved site + Delta-aminolevulinic acid dehydratase, active site + Sulphur transfer protein DsrC/TusE + Adenosine specific kinase + DNA mismatch repair MutH/Restriction endonuclease, type II + Heat shock protein Hsp90, N-terminal + Arm, DNA-binding domain + Sodium/potassium/calcium exchanger + Pseudouridine synthase, TruD + Prokaryotic glutathione synthetase, ATP-binding + Peptidase S26 + Haem oxygenase-like, multi-helical + AdipoR/Haemolysin-III-related + Ribosomal protein L29, conserved site + Fructose-1-6-bisphosphatase class I, N-terminal + Lipopolysaccharide assembly protein A domain + Glutaredoxin subgroup + Malic enzyme, conserved site + Serine proteases, trypsin domain + Transaldolase type 3B/Fructose-6-phosphate aldolase + Enoyl-CoA hydratase/isomerase, HIBYL-CoA-H type + Membrane associated eicosanoid/glutathione metabolism-like domain + MvaI/BcnI restriction endonuclease + Peptidase T2, asparaginase 2 + Transposase IS204/IS1001/IS1096/IS1165, helix-turn-helix domain + Domain of unknown function DUF4332 + Glycosyl hydrolase-like 10 + Succinate dehydrogenase/fumarate reductase iron-sulphur protein + Ribonuclease J + Translation elongation factor SelB, winged helix, type 3 + Chromate transporter + Deoxyguanosinetriphosphate triphosphohydrolase, C-terminal domain + Electron transport complex, subunit RnfC/RsxC + Ribosomal protein L34, conserved site + Glyoxalase I, conserved site + Cytidine deaminase, homotetrameric + Flagellin + Protein of unknown function DUF2442 + Protein of unknown function DUF354 + Glycogen phosphorylase, domain of unknown function DUF3417 + LPS-assembly lipoprotein LptE + ATP-dependent protease, HslV subunit + Tagaturonate epimerase + Flp pilus assembly protein RcpC/CpaB domain + Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, N-terminal + Peptidase S26B + NADP transhydrogenase beta-like domain + TraD/TraG, TraM recognition site + Acetyl-CoA dehydrogenase-like C-terminal domain + L-asparaginase, C-terminal domain + Phosphotransferase system, EIIB component, type 2/3 + Polyphosphate kinase middle domain + Impact, N-terminal + Protein of unknown function DUF3987) + Proline racemase family + CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase + Glycoside hydrolase family 36 + YHS domain + 3Fe-4S ferredoxin + Pilus assembly, Flp-type CpaB + NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site + Glutamine synthetase type I + BolA protein + SAM-dependent methyltransferase TRM5/TYW2-type + Peptidase M54, archaemetzincin + Double transmembrane domain + Peptidase C11, clostripain + TPM domain + Threonine synthase, N-terminal + Carbamoyl-phosphate synthase, large subunit + GTP-binding protein, ribosome biogenesis, YsxC + Glycosyl-hydrolase family 116, N-terminal + Protein of unknown function DUF1006 + Isopropylmalate dehydrogenase + Divergent polysaccharide deacetylase + Domain of unknown function DUF4388 + Manganese/iron superoxide dismutase + DNA-directed RNA polymerase beta subunit, bacterial-type + Glycosyl hydrolase family 95, N-terminal domain + Diacylglycerol/lipid kinase + HflK + Haem peroxidase, plant/fungal/bacterial + DNA recombination and repair protein Rad51-like, C-terminal + L-arabinose isomerase + Serine dehydratase beta chain + Cytochrome c-552/4 + FAD dependent oxidoreductase, central domain + Acetamidase/Formamidase + Dihydrofolate reductase domain + Domain of unknown function DUF306, Meta/HslJ + Cytochrome P450, conserved site + Lysine-2,3-aminomutase/glutamate 2,3-aminomutase + Ribosomal protein S12 methylthiotransferase RimO + Cytidylate kinase-like family + AraC-type arabinose-binding/dimerisation domain + Urocanase conserved site + Glutamate synthase (NADPH), homotetrameric + COX15/CtaA family + Manganese/iron superoxide dismutase, N-terminal + Uncharacterised domain CGGC-dom + Flp/Fap pilin component + Bacterial protein export chaperone SecB + Ribosomal protein S18, conserved site + Alkaline phosphatase D-related + Uncharacterised protein family UPF0012, conserved site + Stage II sporulation protein M-like + Sugar fermentation stimulation protein + Bax inhibitor 1-related + Domain of unknown function DUF4115 + Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, dimerisation domain + Oxoglutarate/iron-dependent dioxygenase + Oligosaccharyl transferase, STT3 subunit + Outer membrane protein, OmpA-like, conserved site + Domain of unknown function DUF1624 + 3-oxoacid CoA-transferase, subunit A + Flagellar basal body-associated protein FliL + CRISPR-associated protein, Cas5 + Glycosyl-hydrolase family 116, catalytic region + Glycerate kinase + Biotin and thiamin synthesis-associated domain + HipA, N-terminal subdomain 1 + Formate C-acetyltransferase glycine radical, conserved site + Glucose-6-phosphate dehydrogenase + Ribosomal protein L22/L17, conserved site + Transcription factor zinc-finger + DhaK domain + YhhN-like + Phage portal protein, lambda family + Transcription factor TFIIB + Uncharacterised protein family UPF0061 + SHOCT domain + Competence-induced protein CinA + Carbamoyltransferase, C-terminal + Phosphosugar isomerase, KdsD/KpsF-type + Proline dehydrogenase domain + Thrombospondin, type 3-like repeat + Domain of unknown function DUF2179 + Glycoside hydrolase family 16 + Cytochrome c-type biogenesis protein + Ketopantoate reductase ApbA/PanE + Peptidase family S66 + Phosphoenolpyruvate synthase + Condensation domain + Aminopeptidase P, N-terminal + PepSY-associated TM protein + ATPase, OSCP/delta subunit, conserved site + GWxTD domain + Type III secretion system inner membrane R protein + Beta-hexosaminidase + Uronate isomerase + Phosphoribosylformylglycinamidine subunit PurL + Conserved hypothetical protein CHP04255 + Cysteine synthase CysK + Acetylornithine/Succinylornithine transaminase family + Protein of unknown function DUF429 + Protein of unknown function DUF4198 + Molybdenum cofactor sulfurase, C-terminal + Pyridoxal 5'-phosphate synthase subunit PdxS/SNZ + Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase + G5 domain + Purine nucleoside phosphorylase + Glucokinase + Protein of unknown function DUF3096 + Domain of unknown function DUF234, DEXX-box ATPase C-terminal + CRISPR-associated protein Cas5, N-terminal + SprB repeat + Type III secretion system inner membrane P protein + Sialic acid O-acyltransferase NeuD-like + Conserved hypothetical protein CHP02391 + Methylpurine-DNA glycosylase (MPG) + Cyclic-di-AMP receptor + Transcription factor TFIIB, cyclin-like domain + Mannitol dehydrogenase, C-terminal + NADH-plastoquinone oxidoreductase, chain 5 subgroup + Aromatic-ring-hydroxylating dioxygenase, alpha subunit + Peptidase M55, D-aminopeptidase + VIT domain + Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase, prokaryotic + Putative nitroreductase TM1586 + Acetate-CoA ligase + Lipopolysaccharide export system protein LptC + RNA 3'-terminal phosphate cyclase, insert domain + DNA ligase, ATP-dependent, N-terminal + Iron hydrogenase, large subunit, C-terminal + Ribosomal protein L21, conserved site + YscD, cytoplasmic domain + Maltogenic Amylase, C-terminal + Alpha-L-arabinofuranosidase, C-terminal + Fructose-1,6-bisphosphatase + Prismane, alpha-bundle + Poly-beta-hydroxybutyrate polymerase, N-terminal domain + Conserved hypothetical protein CHP00255 + Bacteriophage HK97-gp10, putative tail-component + ECF transporter, substrate-specific component-like + Protein of unknown function UPF0301 + Flagellar hook-length control protein-like, C-terminal + Coenzyme F420:L-glutamate ligase-like domain + NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site + Pyruvate kinase, active site + NnrS + Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein + Acetate/propionate kinase + 4-oxalocrotonate tautomerase + Adenine phosphoribosyl transferase + Gamma-glutamylcyclotransferase, AIG2-like + UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase LpxD + FeS cluster insertion, C-terminal, conserved site + ATPase, AFG1-like + Peptidase S26A, signal peptidase I, serine active site + Acetate transporter GPR1/FUN34/SatP family + UTP--glucose-1-phosphate uridylyltransferase, bacterial/archaeal-type + Flagellar motor switch protein FliG, N-terminal domain + D-3-phosphoglycerate dehydrogenase + Carboxyltransferase domain, subdomain A and B + Tyrosine-protein kinase, active site + D-aminopeptidase, N-terminal + Cytochrome P450, B-class + General secretion pathway protein K + Phosphoenolpyruvate carboxykinase, GTP-utilising, C-terminal + Arylsulfotransferase, C-terminal + Photosynthesis system II assembly factor Ycf48/Hcf136-like domain + Ubiquinone biosynthesis hydroxylase UbiH/COQ6 + PFTB repeat + Domain of unknown function DUF5107 + TonB box, conserved site + DEAD2 + NarG-like domain + Bacterial alpha-L-rhamnosidase N-terminal + Pseudouridine-5'-phosphate glycosidase + Flagellar motor switch protein FliG, C-terminal + Galactose-1-phosphate uridyl transferase, C-terminal + Protein of unknown function DUF4432 + Galactose-1-phosphate uridyl transferase, class I + Acylphosphatase + Phasin + Mannose-6-phosphate isomerase, type I + Tyrosine recombinase XerD + Tip attachment protein J + Putative oxidoreductase/dehydrogenase, Rossmann-like domain + Protein of unknown function DUF368 + Lipoyl synthase, N-terminal + YbbR-like + CstA, C-terminal domain + ABC transporter, permease PhnE/PtxC + Manganese/iron superoxide dismutase, binding site + Inositol monophosphatase, SuhB + Adhesin B + Peptidase S1C, Do + Single Cache domain 2 + Fe-S metabolism associated domain, SufE-like + Protein of unknown function DUF990 + 2-isopropylmalate synthase, bacterial-type + Phenylalanine/histidine ammonia-lyases, active site + Peptidase C39, bacteriocin processing + Cytochrome b/b6, N-terminal + Domain of unknown functionDUF2779 + RecD helicase-like helix-hairpin-helix domain + Uncharacterised protein family UPF0313, N-terminal + Activator of Hsp90 ATPase homologue 1-like + eRF1 domain 2 + Protein of unknown function DUF1819, putative inner membrane + ATP-grasp fold, ATP-dependent carboxylate-amine ligase-type + Nucleoside phosphorylase, conserved site + Coproporphyrinogen III oxidase, aerobic + YibE/F-like + Nitrilase/cyanide hydratase, conserved site + Phosphotransferase system, sugar-specific permease component + MORN variant + Glutamine-tRNA synthetase + Aspartate carbamoyltransferase regulatory subunit, C-terminal + H repeat-associated protein, N-terminal + DNA ligase, ATP-dependent, conserved site + Cytochrome c oxidase subunit II-like C-terminal + Conserved hypothetical protein CHP03960, radical SAM + TSCPD domain + LD-carboxypeptidase A, C-terminal domain + Outer membrane protein assembly factor BamA + tRNA modification GTPase MnmE + Microcompartment protein, bacteria + DNA recombination/repair protein RecN + 3-beta hydroxysteroid dehydrogenase/isomerase + 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase + Ribonuclease II/R, conserved site + Beta-propeller repeat + Type II bacterial toxin-antitoxin system, ParE-like toxin + 4-vinyl reductase, 4VR + Tumour necrosis factor-like domain + Chorismate mutase, AroH class + Ammonium transporter + Polyphosphate kinase 2, PA0141 + Murein tetrapeptide carboxypeptidase, N-terminal domain + Rhamnose/fucose mutarotase + Molybdate ABC transporter, substrate-binding protein + Cytochrome c oxidase, monohaem subunit/FixO + Uncharacterised membrane protein YitT + Resolvase, HTH domain + Porphobilinogen deaminase, dipyrromethane cofactor binding site + Sporulation stage II protein D, amidase enhancer LytB + Restriction endonuclease, type II, BamHI/BglIII/BstY + Deoxyhypusine synthase + Proton-dependent oligopeptide transporter family + Protein of unknown function DUF389 + TolB, N-terminal + Branched-chain amino acid transport, permease + Baseplate protein J-like + Protein of unknown function DUF951 + Ribosomal S6 modification enzyme RimK/Lysine biosynthesis enzyme LysX + Oligopeptide transporter, OPT superfamily + Tetratricopeptide repeat-like domain + Uncharacterised protein family UPF0296 + Putative fluoride ion transporter CrcB + CRISPR-associated protein Cas4 + Putative cell wall binding repeat 2 + Rod shape-determining protein RodA + Terminase large subunit, Lambdalikevirus-type + N-acetylglucosaminyltransferase, MurG + Paraquat-inducible protein A + Protein of unknown function DUF481 + Acyclic terpene utilisation + CHAD domain + Redox-active disulphide protein 2 + Citramalate synthase + Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site + Putatuve nitroreductase, C-terminal, bacterial + Toluene tolerance Ttg2/phospholipid-binding protein MlaC + Electron transport complex, RsxE + Protein of unknown function DUF1464 + Uncharacterised protein family UPF0371 + FixG, C-terminal immunoglobulin-like domain + Nucleotide-binding protein, predicted, TIR-like domain + Senescence marker protein-30 (SMP-30) + RbsD-like domain + Pyruvate-flavodoxin oxidoreductase, EKR domain + Domain of unknown function DUF4062 + Positive regulator of sigma(E), RseC/MucC + Ribosomal protein L33, conserved site + Cryptochrome/DNA photolyase, FAD-binding domain + Major intrinsic protein + Flagellar M-ring C-terminal + Domain of unknown function DUF1565 + Carboxyltransferase domain, subdomain C and D + Translation elongation factor SelB, winged helix, type 2 + Glycoside hydrolase, family 65, central catalytic + Zinc finger/thioredoxin putative + Bacteriophage phiJL001, Gp84, N-terminal + Ribulose bisphosphate carboxylase, large subunit, ferrodoxin-like N-terminal + ChrR-like cupin domain + Formiminotransferase catalytic domain + Polymorphic outer membrane protein repeat + MetA-pathway of phenol degradation, putative + Glutaminyl-peptide cyclotransferase + Uncharacterised protein family UPF0093 + Flagellar motor switch FliN/Type III secretion HrcQb + Deoxycytidine triphosphate deaminase, bacterial + Cytochrome c-type biogenesis protein CcmF + Transposase, IS30, conserved site + Neutral/alkaline non-lysosomal ceramidase, N-terminal + Cysteine peptidase, histidine active site + Glycoside hydrolase, family 2, active site + Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal + Small multidrug resistance protein family + Antitoxin ParD + Gram-negative bacterial TonB protein + Squalene cyclase, C-terminal + Death on curing protein + Replication initiator protein A + CHASE domain + Secretory protein YscJ/FliF + Domain of unknown function DUF3857 + Histidine biosynthesis HisG, C-terminal + Toxin-antitoxin system, YafQ-like toxin + Major facilitator superfamily associated domain + Nicotinate phosphoribosyltransferase family + Asparagine-tRNA ligase + Desulfoferrodoxin + Polyphosphate kinase N-terminal domain + 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase + Cytochrome-c3 hydrogenase, C-terminal + Pyruvate, phosphate dikinase + Flagellar motor switch protein FliG, middle domain + PD-(D/E)XK nuclease superfamily 4 + VCBS repeat + OST-HTH/LOTUS domain + Alpha-glycerophosphate oxidase, C-terminal + ANTAR domain + Phage head morphogenesis domain + Uncharacterised protein family UPF0276 + Putative HupE/UreJ protein + dCTP pyrophosphatase 1 + Flagellar motor protein MotA, conserved site + Cobalamin (vitamin B12) biosynthesis CobW-like, C-terminal + Heat shock protein HslU + AP endonuclease 1, conserved site + Glycosyl transferase family 39/83 + Conserved hypothetical protein CHP02231 + Peptidase S33 + ATP-dependent 6-phosphofructokinase, prokaryotic + Ureidoglycolate lyase domain + Protein of unknown function UPF0178 + Putative, 10TM heavy-metal exporter + O-methyltransferase, family 2 + DNA-directed DNA polymerase, family B, exonuclease domain + Endonuclease III + L-aspartate oxidase + Flagella basal body P-ring formation protein FlgA, C-terminal + Cytochrome c-type biogenesis protein CcmB + Type II secretion system protein H + Fructose-1,6-bisphosphatase class 2/Sedoheputulose-1,7-bisphosphatase + Protein of unknown function DUF456 + Phosphoglucose isomerase, C-terminal + PhnA protein, C-terminal + Tetrapyrrole biosynthesis, glutamyl-tRNA reductase + ASCH domain + Glutamate--cysteine ligase, GCS2 + Serine acetyltransferase, N-terminal + Protein of unknown function DUF2284, metal-binding + Haemolysin A /rRNA methyltransferase TlyA + Major intrinsic protein, conserved site + Alpha-L-rhamnosidase C-terminal domain + HAD-superfamily hydrolase, subfamily IB, SerB1-like + Electron transport complex, subunit RnfD/RsxD + Amino acid permease/ SLC12A domain + 1,2-phenylacetyl-CoA epoxidase, subunit A/C + Lytic transglycosylase MltA, domain B + Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase + Ribosomal protein L36 + Fatty acid synthase + Thiamin pyrophosphokinase, catalytic domain + Peptide chain release factor 3, C-terminal + FeS cluster assembly SUF system, ATPase SufC + Protein of unknown function DUF2089 + Restriction endonuclease ThaI + Imidazolonepropionase + DMSO/Nitrate reductase chaperone + Acetyl-CoA carboxylase, biotin carboxylase + PrpF protein + Butyrate kinase + Transcriptional coactivator/pterin dehydratase + DNA polymerase III, delta prime subunit + Catalase core domain + L-2-amino-thiazoline-4-carboxylic acid hydrolase + Major capsid protein GpE + Nuclease SbcCD subunit D + Heat shock protein Hsp33 + Adhesion lipoprotein + Helicase Cas3, CRISPR-associated, core + Chaperonin ClpB + Squalene/phytoene synthase + TupA-like ATPgrasp protein + Serine proteases, trypsin family, histidine active site + 3-deoxy-D-manno-octulosonate cytidylyltransferase + Beta-lactamase hydrolase-like + Rare lipoprotein A + YcaO-like domain + MlaA lipoprotein + Plasmid replication-relaxation + Cytochrome ubiquinol oxidase subunit 2 + Beta galactosidase small chain/ domain 5 + Alpha-L-rhamnosidase, concanavalin-like domain + Peptidase M1, alanyl aminopeptidase, C-terminal + Mannitol dehydrogenase, N-terminal + Domain of unknown function DUF4277 + CbbQ/NirQ/NorQ, C-terminal + Protein of unknown function DUF1329 + 3-deoxy-8-phosphooctulonate synthase + Inosine-5'-monophosphate dehydrogenase + GTP-binding protein OBG, C-terminal + Flagellar transport protein FliP + Cytochrome c-type biogenesis protein CcmC + Calycin + Domain of unknown function DUF2281 + Malate synthase + Bacterial export protein family 3 + RND efflux system, outer membrane lipoprotein, NodT + D-ribose pyranase RbsD/L-fucose mutarotase FucU + Peptidyl-prolyl cis-trans isomerase, FKBP-type, N-terminal + Helicase-associated domain + Lytic murein transglycosylase + ABC transport permease subunit MlaE, Proteobacteria + HflC + Putative collagen-binding domain + Ribonuclease B, N-terminal OB domain + Phosphate/phosphite/phosphonate ABC transporter, periplasmic binding protein + Cobalamin-independent methionine synthase MetE, C-terminal/archaeal + Carbonic anhydrase, prokaryotic-like, conserved site + DNA photolyase, N-terminal + Dihydrofolate reductase + Protein of unknown function DUF2905 + GerMN domain + Serine O-acetyltransferase + Rex DNA-binding, C-terminal domain + MORN motif + NnrU domain + Flagellar L-ring protein + Domain of unknown function DUF4340 + Putative adhesin + Alanine dehydrogenase + Electron transport complex, subunit RnfA/RsxA + Protein of unknown function DUF805 + Uncharacterised domain UPF0126 + Thymidine kinase, conserved site + Flavin-dependent halogenase + Bacterial Ig-like, group 2 + Divalent ion tolerance protein, CutA + Carbon storage regulator + Phthalate dioxygenase reductase + Histone acetyltransferase ELP3 + RES domain + Peptidogalycan biosysnthesis/recognition + Initiator Rep protein + Domain of unknown function DUF4124 + Disulphide bond formation protein DsbB-like domain + Bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase + AP2/ERF domain + Phosphate binding protein + Peptidase M75, Imelysin + Phosphoenolpyruvate carboxykinase, GTP-utilising, N-terminal + Flagellar hook capping protein + Peptidase M20C, Xaa-His dipeptidase + Acyl-CoA dehydrogenase, N-terminal, bacteria + Protein of unknown function DUF1667 + Glycerol kinase + Alkaline phosphatase + Glucose-6-phosphate dehydrogenase, active site + Bifunctional kinase-pyrophosphorylase + Sodium/sulphate symporter, conserved site + O-methyltransferase, family 3 + CcmE/CycJ protein + Protein of unknown function DUF1847 + Protein of unknown function DUF901 + FIST domain, N-terminal + L-asparaginase II + Adenine-specific methyltransferase, domain 2 + Putative glutamine amidotransferase type 2 + Transcription factor LuxR-like, autoinducer-binding domain + Adenine deaminase + HI0933 insert-like domain + Conserved hypothetical protein CHP02757 + Type I secretion membrane fusion protein, HlyD family + Transcriptional regulator, AbiEi 2 antitoxin, Type IV TA system + Trp repressor + Branched-chain amino acid transport, AzlD + Thiamin pyrophosphokinase, vitamin B1-binding domain + Uracil phosphoribosyl transferase + Peptidase S51 + Sugar/inositol transporter + KDPG/KHG aldolase, active site 2 + Glycoside hydrolase, family 37 + Disulphide bond formation protein DsbB/BdbC + Phosphotriesterase + Cytochrome C oxidase subunit II, transmembrane domain + Protein-PII uridylyltransferase, N-terminal + Adenosine/adenine deaminase + Microcystin LR degradation protein MlrC, C-terminal + Arsenate reductase + Hypothetical glycosyl hydrolase family 15 + RHS protein + RNA-binding protein Hfq + L-seryl-tRNA(Sec) selenium transferase + Electron transport complex, RnfB/RsxB + YCII-related + Galactokinase, conserved site + Copper centre Cu(A) + Uncharacterised protein family UPF0271, LamB/YcsF + Peptidase S11, D-Ala-D-Ala carboxypeptidase A, C-terminal + Bacteriophage phiJL001, Gp84, C-terminal + Isopenicillin N synthase-like + Cytochrome oxidase maturation protein cbb3-type + 2-oxoglutarate dehydrogenase E1 component, N-terminal domain + Tagatose/fructose phosphokinase + Domain of unknown function DUF4433 + Urocanase + eRF1 domain 3 + Acid phosphatase/vanadium-dependent haloperoxidase-related + Domain of unknown function DUF294, putative nucleotidyltransferase substrate-binding + SUI1 domain + Glutathione peroxidase + Integrin alpha chain + L-lactate permease + D-serine dehydratase-like domain + Xylose isomerase + Arsenical pump membrane protein, ArsB + Topoisomerase C-terminal repeat + Pilus formation protein, N-terminal + Gluconate transporter + 3-dehydroquinate dehydratase type I + PaaX-like, C-terminal + Methanolan biosynthesis EpsI + Orotate phosphoribosyltransferase, bacterial + GTA TIM-barrel-like domain + Transketolase, bacterial-like + Tryptophan synthase, beta chain-like + FxsA cytoplasmic membrane protein + Ada DNA repair, metal-binding + RelB antitoxin/Antitoxin DinJ + Prokaryotic glutathione synthetase, N-terminal + Carbohydrate deacetylase YdjC-like + Coenzyme Q-binding protein COQ10, START domain + Glycosyl transferase, family 14 + Carboxylesterase, type B + Flagellar M-ring protein FliF + Domain of unknown function DUF2437 + Ribonuclease J, conserved site + Protein of unknown function DUF4416 + Alpha-L-fucosidase, C-terminal + Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain + PTR2 family proton/oligopeptide symporter, conserved site + Aspartate kinase, monofunctional class + Cbb3-type cytochrome c oxidase subunit CcoP, N-terminal + MnmC-like methyltransferase + Thiaminase-2/PQQC + Ribosomal protein S16, conserved site + Siroheme synthase, central domain + Formyltetrahydrofolate deformylase + BNR repeat + Dual specificity phosphatase, catalytic domain + Protein of unknown function DUF998 + Aminoglycoside N(3)-acetyltransferase + Uncharacterised protein family UPF0210 + Microcystin LR degradation protein MlrC, N-terminal + Twin-arginine translocation protein TatB + Mannosyl-3-phosphoglycerate synthase + Heat shock protein Hsp33, N-terminal + Conserved hypothetical protein CHP02574, addiction module + NADPH-dependent 7-cyano-7-deazaguanine reductase, QueF type 1 + Diadenylate cyclase CdaA + tRNA-dihydrouridine synthase, TIM-barrel, NifR3 + Pyridoxamine 5'-phosphate oxidase + Domain of unknown function DUF4007 + Membrane protein, 6-pyruvoyl-tetrahydropterin synthase-related domain + Transcription factor, NikR, nickel binding C-terminal + Penicillin-binding protein, OB-like domain + GTP-binding protein TypA + Flagellar hook-basal body complex protein FliE + Cyclophilin TM1367-like domain + CDC48 domain 2-like + Galactose oxidase, beta-propeller + Uncharacterised protein YjbR + Domain of unknown function DUF4372 + TM2 domain + ATP phosphoribosyltransferase, conserved site + Formylmethanofuran: tetrahydromethanopterin formyltransferase Ftr, ferredoxin-like domain + Pyridoxine 5'-phosphate oxidase, dimerisation, C-terminal + Uracil-DNA glycosylase, active site + Hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase + Heat shock protein Hsp33, C-terminal + Domain of unknown function DUF2075 + DAHP synthetase, class II + Protein of unknown function DUF463, YcjX-like protein + Transglycosylase-associated protein + Protein of unknown function DUF2460 + Ribosomal protein S21, conserved site + Type II secretion system GspD, conserved site + PHA accumulation regulator DNA-binding, N-terminal + Bacterial/plant glycogen synthase + JAB domain, prokaryotic + Bifunctional phosphoglucose/phosphomannose isomerase + Putative sugar-binding, N-terminal domain + Protein of unknown function DUF393 + Domain of unknown function DUF3473 + Haemerythrin, metal-binding domain + Proline-tRNA ligase, class IIa, archaeal-type + FdhE-like + DHHA2 domain + Small GTPase superfamily, ARF/SAR type + WHG domain + Flagellar protein FlgJ, N-terminal + DAK2 domain-containing protein YloV + C-methyltransferase + Indolepyruvate ferredoxin oxidoreductase, alpha subunit + Ribosomal RNA small subunit methyltransferase F, N-terminal + Glycoside hydrolase family 15/Phosphorylase b kinase regulatory chain family + Protein of unknown function DUF1684 + Glycoside hydrolase family 31, N-terminal domain + Phosphoenolpyruvate carboxylase + Pirin, C-terminal domain + 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD + Endonuclease I + Protohaem IX farnesyltransferase + 3-isopropylmalate dehydratase, small subunit + Glycine betaine transport ATP-binding subunit + Spermidine synthase, tetramerisation domain + L-fucose isomerase, N-terminal-2 + ssDNA-binding transcriptional regulator + Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site + Stringent starvation protein B + FIST, C-domain + Glycosyl hydrolase family 98, putative carbohydrate-binding module + Peptidyl-arginine deiminase, Porphyromonas-type + Transcription factor CBF/NF-Y/archaeal histone domain + Phosphoglucosamine mutase, bacterial type + CRISPR-associated protein Cas7, subtype I-B/I-C + Protein of unknown function DUF350 + Pyruvate ferredoxin oxidoreductase beta subunit, C-terminal + NapC/NirT cytochrome c, N-terminal + Glucose-6-phosphate isomerase, prokaryote + 6-hydroxymethylpterin diphosphokinase MptE-like + Ferric reductase transmembrane component-like domain + Glycoside hydrolase, family 5, conserved site + Thiamin pyrophosphokinase + Acyl-protein synthetase, LuxE + HB1/Asxl, restriction endonuclease HTH domain + Intracellular septation protein A + Phosphopentomutase DeoB cap domain + Hydroxymethylglutaryl-CoA reductase, bacterial-type + Alpha-amylase/branching enzyme, C-terminal all beta + Lactate racemization operon protein LarE + Flagellar hook protein FlgE + Integrase, integron-type + Toxin YoeB + N-acetylglucosamine-6-phosphate deacetylase + Phytanoyl-CoA dioxygenase + FRG domain + Putative inner membrane exporter, YdcZ + Protein of unknown function DUF484 + PspA/IM30 + Protein of unknown function DUF2971 + CcmH/CycL/Ccl2/NrfF family + AttH-like domain + Protein of unknown function DUF3768 + Structural maintenance of chromosomes protein, prokaryotic + Pyrimidine-nucleoside phosphorylase, conserved site + Protein of unknown function DUF554 + SepSecS/SepCysS family + Cytochrome b/b6, C-terminal + Protein of unknown function DUF4160 + Phage-like element PBSX protein, XkdF + DEAD/H associated + Exopolysaccharide biosynthesis protein YbjH + Haem-binding uptake, Tiki superfamily, ChaN + Peptidase C56, PfpI + Exosortase, EpsH + General secretion pathway protein G + Domain of unknown function DUF4352 + NADH-plastoquinone oxidoreductase, chain 5 + D-tagatose-bisphosphate aldolase, non-catalytic subunit GatZ/KbaZ + Cobyric acid synthase CobQ + Type-2 restriction enzyme BglII + DNA-directed DNA polymerase, family B, conserved site + Methionine biosynthesis MetW + VTC domain + Asparaginase/glutaminase, active site 1 + 7TM-DISM receptor, extracellular domain, type 1 + Nitrogen fixation protein FixH + Cell division protein FtsW + Phosphoserine phosphatase, domain 2 + V-ATPase proteolipid subunit + Heavy-metal resistance protein + Protein of unknown function DUF2188 + Beta-phosphoglucomutase hydrolase + AMP-activated protein kinase, glycogen-binding domain + Tetracycline transcriptional regulator, TetR-related, C-terminal + Glucosamine-6-phosphate isomerase, conserved site + PGF-CTERM archaeal protein-sorting signal + Ysc84 actin-binding domain + Protein of unknown function DUF1009 + DNA topoisomerase IV, subunit B, Gram-negative + Domain of unknown function DUF2235 + Protein of unknown function DUF1028 + TauD/TfdA-like domain + CDC48, N-terminal subdomain + Reductive dehalogenase + Sirtuin family, catalytic core small domain + Bacteriophage lambda, GpO, N-terminal + Protein of unknown function DUF4249 + Sulphate adenylyltransferase + Replication modulator SeqA, C-terminal DNA-binding domain + Ribonuclease II/ribonuclease R + Cobalamin (vitamin B12) biosynthesis CobH/CbiC, precorrin-8X methylmutase + Protein of unknown function DUF308, membrane + Cell wall hydrolase, SleB + Nudix hydrolase, N-terminal + Chromate resistance exported protein + Secretin/TonB, short N-terminal domain + Ureidoglycolate lyase + Conserved hypothetical protein CHP00251 + Phosphatidylserine decarboxylase, archaeal-type + Putative sensory transduction regulator YbjN + Peptidase M18 + Dethiobiotin synthase BioD + Fumarate reductase/succinate dehydrogenase, FAD-binding site + Rieske iron-sulphur protein, C-terminal + Transcription regulator YsiA, C-terminal + Bacteriophage phiJL001, Gp84 + Purine nucleoside phosphorylase I, inosine/guanosine-specific + Phosphodiester glycosidase + Inner membrane protein YedI + Sulphur oxidation protein SoxZ + Protein of unknown function DUF983 + 7 transmembrane helices usually fused to an inactive transglutaminase + Deoxyguanosinetriphosphate triphosphohydrolase, central domain + Transglutaminase-like cysteine peptidase, predicted + Cytochrome c, class II + Cytochrome c1 + HAD-superfamily hydrolase, superfamily IIB, MPGP + Glutamyl-tRNA reductase, conserved site + Na(+)-translocating NADH-quinone reductase subunit A + Domain of unknown function DUF1508 + Protein of unknown function DUF697 + Ubiquinone biosynthesis O-methyltransferase + NADH dehydrogenase, subunit C + Malic oxidoreductase + General secretion pathway, GspH + Protein of unknown function DUF900, hydrolase-like + Monothiol glutaredoxin-related + Drug resistance transporter Bcr/CmlA subfamily + Domain of unknown function DUF1553 + Bacteriophage T4, Gp19, tail tube + Glycosyl hydrolase family 32, C-terminal + Protein of unknown function DUF1788 + Flagellar hook-associated protein 1 + ABC-type transport auxiliary lipoprotein component + Phage portal protein, HK97 + DNA ligase D, 3'-phosphoesterase domain + Protein of unknown function DUF285 + Protein-tyrosine phosphatase, active site + Non-canonical purine NTP phosphatase/PRRC1 + Tail completion protein + Copper chaperone PCuAC + Sporulation stage V, protein S + Putative exodeoxyribonuclease 8, PDDEXK-like domain + Domain of unknown function DUF2147 + Sodium symporter small subunit, predicted + Formaldehyde-activating enzyme + Truncated hemoglobin + Protein of unknown function DUF2793 + Conserved hypothetical protein CHP02302, transmembrane + Restriction endonuclease, type I, HsdM + Mechanosensitive ion channel MscS, conserved site + 2-oxoacid:acceptor oxidoreductase, alpha subunit + Acetylserotonin O-methyltransferase, dimerisation domain + Cryptochrome/DNA photolyase class 1 + Protein of unknown function DUF3365 + Dynamin superfamily + Purine-cytosine permease + Peptidoglycan-associated lipoprotein + Catalase-peroxidase haem + Tetrahydrodipicolinate-N-succinyltransferase, chain A, domain 1 + Restriction endonuclease, type II, DpmII-like + Malectin + Hydroxyacylglutathione hydrolase, C-terminal domain + Protein of unknown function DUF847 + Protein of unknown function DUF1058 + Single cache domain 3 + Domain of unknown function DUF547 + Chemotaxis methyl-accepting receptor HlyB-like, 4HB MCP domain + Uncharacterised conserved protein UCP008505 + WxcM-like, C-terminal + Protein of unknown function DUF1893 + L-seryl-tRNA selenium transferase N-terminal domain + Flagellin/pilin, N-terminal + Endonuclease relaxase, MobA/VirD2 + Voltage-dependent anion channel + Cytochrome c oxidase cbb3 type, accessory protein FixG + RAD50, zinc hook + Triphosphoribosyl-dephospho-CoA protein + Integron-associated effector binding protein + Polyphosphate kinase + Protein of unknown function DUF1295 + Nucleotidyltransferase substrate binding protein, HI0074 + Protein FecR, C-terminal + Protein of unknown function DUF748 + TGF-beta, propeptide + Dihydroorotate dehydrogenase, class 2 + Pyrimidine-nucleoside phosphorylase, bacterial/eukaryotic + Winged helix-turn-helix transcription repressor, HrcA DNA-binding domain + Glycerate kinase, flavodoxin-like domain + Threonyl-tRNA synthetase, editing domain, archaea + NIF system FeS cluster assembly, NifU-like + tRNA (1-methyladenosine) methyltransferase catalytic subunit Gcd14 + 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, prokaryotes + Domain of unknown function DUF4440 + Ribosomal protein L30, conserved site + Ig-like SoxY domain + Uncharacterised protein DUF2154, N-terminal + LSM domain, eukaryotic/archaea-type + Protein of unknown function DUF4956 + ABC transporter, phosphonate import, PhnC + DivIVA family + Domain of unknown function DUF4339 + HPP + Protein of unknown function DUF4389 + Formylmethanofuran: tetrahydromethanopterin formyltransferase Ftr, N-terminal + Glycoside hydrolase family 10 domain + Domain of unknown function DUF4369 + BrnA antitoxin of type II toxin-antitoxin system + Adrenodoxin + Domain of unknown function DUF2061, membrane + Zinc finger, TFIIB-type + Gluconeogenesis factor + Nucleoside diphosphate pyrophosphatase + CRISPR-associated protein Cas6, C-terminal + Protein of unknown function DUF1285 + Domain of unknown function DUF1648 + RNA polymerase-binding transcription factor DksA + Glycerol-1-phosphate dehydrogenase + KduI/IolB isomerase + Glycosyl hydrolases family 1, N-terminal conserved site + Protein of unknown function DUF454 + Bacterial surface protein 26-residue repeat + Protein of unknown function DUF4177 + Phosphotransferase system, EIIC + Tn3 transposase DDE domain + Protein of unknown function DUF2911 + MtfA family + Dipeptide/tripeptide permease + HPr kinase/phosphorylase, C-terminal + Translation elongation factor, selenocysteine-specific + Aromatic-L-amino-acid decarboxylase + RNA polymerase sigma factor 70, non-essential domain + Glycogen debranching enzyme, C-terminal + Protein of unknown function DUF423 + Alpha-macroglobulin complement component + ACT-like domain + Ribosomal protein L11 methyltransferase + NifH/frxC family + Flagellar motor switch protein FliM + Tungstate ABC transporter, substrate-binding protein WtpA + Glycosyl-hydrolase 97, catalytic domain + Outer membrane protein, OmpW + Surfeit locus 1/Shy1 + DNA/RNA-binding protein Alba-like + DNA helicase, ATP-dependent, RecQ type, bacterial + Domain of unknown function DUF2202 + Glucose-1-phosphate thymidylyltransferase, long form + Uncharacterised protein family UPF0324, prokaryote + Domain of unknown function DUF2083,transcriptional regulator + Transcriptional regulator HTH-type, FeoC + Heat shock protein Hsp90, conserved site + Lipoate protein ligase, C-terminal + Thiamine/thiamin pyrophosphate-binding periplasmic protein, ABC transporter + TfoX, N-terminal + Menaquinone biosynthesis enzyme + Nucleoside 2-deoxyribosyltransferase + Protein of unknown function DUF2927 + Flagellar hook-associated protein 2, N-terminal + NAD(P) transhydrogenase, alpha subunit, C-terminal + Flagellar hook-associated 2, C-terminal + Peptidase M1, alanyl aminopeptidase, Ig-like fold + Succinate dehydrogenase, cytochrome b556 subunit + Alpha-ketoglutarate-dependent dioxygenase AlkB-like + Post-segregation antitoxin CcdA + Arsenical-resistance protein Acr3 + Cell division protein FtsL + Transferase 1, rSAM/selenodomain-associated + Cysteine desulfurase, SufS + Pyridoxamine 5'-phosphate oxidase, conserved site + Type II restriction endonuclease EcoO109IR + Mevalonate kinase + ThiS, thiamine-biosynthesis + Malate dehydrogenase, type 3 + Heavy metal-associated domain, copper ion-binding + Transcription regulator HTH, Crp-type, conserved site + Protein of unknown function DUF4386 + Late embryogenesis abundant protein, LEA-14 + Protein of unknown function DUF3394 + Stage V sporulation protein G + Flagellin hook, IN motif + Alpha-2-macroglobulin, thiol-ester bond-forming + SurA N-terminal + Catalase, mono-functional, haem-containing + S-adenosylmethionine synthase + Cbb3-type cytochrome oxidase component + Peptidase family U32, C-terminal + Type III restriction/modification enzyme methylation subunit + Cysteine desulfurase NifS, bacterial/archaeal + Flavin monooxygenase-like + DNA primase/nucleoside triphosphatase, C-terminal + Dihydroneopterin aldolase + Tricorn protease, PDZ domain + Helicase XPB/Ssl2, N-terminal domain + Transposase-like, Mu, C-terminal + Cell division protein FtsE, ATP-binding + DNA ligase, ATP-dependent + Poly granule associated + Ubiquitinol-cytochrome C reductase, Fe-S subunit, TAT signal + SpoIIAA-like + Uncharacterised protein family UPF0216 + Uncharacterised protein family UPF0313, C-terminal + DNA polymerase III, delta subunit, C-terminal + Winged helix-turn-helix transcription repressor, HrcA, inserted dimerising domain + Cell division coordinator CpoB, C-terminal + Xylulokinase + Clan AA aspartic peptidase, C-terminal + Domain of unknown function DUF4136 + Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6, conserved site + Glycoside-hydrolase family GH114, TIM-barrel domain + 3(2),5 -bisphosphate nucleotidase, bacterial + Type-1 restriction enzyme R protein, C-terminal + Arginine-tRNA-protein transferase, C-terminal + RecT family + DNA damage-inducible protein DinB + ERCC4 domain + VRR-NUC domain + Fn3 associated repeat + Glutathione-specific gamma-glutamylcyclotransferase + ABC transporter, haem export, CcmA + Nitrogenase component 1, conserved site + HemY, N-terminal + PilC beta-propeller domain + Formylmethanofuran: tetrahydromethanopterin formyltransferase Ftr, C-terminal + Type I secretion outer membrane protein, TolC + Flagellar basal-body rod protein FlgC + Protein of unknown function DUF2196 + Cobalt ECF transporter T component CbiQ + Uncharacterised domain CHP00451 + NAD(P)H-quinone oxidoreductase, subunit N/subunit 2 + Cytochrome c, class IC + Domain of unknown function DUF2384 + Protein of unknown function DUF819 + Inosine/uridine-preferring nucleoside hydrolase, conserved site + Helicase SWF/SNF-related + Putative glycosyl hydrolase domain DUF4015 + Adenylosuccinate lyase PurB, C-terminal + tRNA(Ile)-lysidine synthase , substrate-binding domain + Glycosyl-hydrolase 97, N-terminal domain + Protein of unknown function DUF924 + Succinate dehydrogenase, hydrophobic membrane anchor + Cobalamin (vitamin B12) biosynthesis CbiX + Lysozyme domain + Concentrative nucleoside transporter C-terminal domain + Protein of unknown function DUF1499 + DNA-binding protein VF530-like + Uroporphyrinogen decarboxylase HemE + Glycoside hydrolase, family 28 + Fructose-bisphosphate aldolase, class-I + Electron transport complex, subunit RnfG/RsxG + Heparinase II, N-terminal + Xanthine/uracil permease + Fructose-1,6-bisphosphatase, active site + Protein of unknown function DUF932 + DNA polymerase III chi subunit, HolC + GpW/Gp25/anti-adapter protein IraD + Hly-III + DNA-directed DNA polymerase, family B, mitochondria/virus + Aconitase B, swivel + Protein of unknown function DUF2330 + Protein of unknown function DUF3422 + Rhamnose isomerase + CRISPR-associated protein, Cas6 + Restriction endonuclease, type II, AlwI + Ribosomal protein L7Ae/L30e/S12e/Gadd45 + Citrate lyase, alpha subunit + Domain of unknown function DUF1972 + 6-phosphogluconate dehydrogenase, decarboxylating + Holin of 3TMs, for gene-transfer release + S-adenosylmethionine decarboxylase proenzyme + Histidine ammonia-lyase + Penicillin-binding, C-terminal + Putative glutamine amidotransferase + Restriction endonuclease, type II, EcoRV + Peptidase C1B, bleomycin hydrolase + Protein of unknown function DUF1844 + Protein of unknown function DUF1194 + Terminase small subunit + Phosphotransferase system, HPr serine phosphorylation site + Geranylgeranylglyceryl phosphate synthase/Heptaprenylglyceryl phosphate synthase + FR47-like + [NiFe]-hydrogenase, small subunit + Lipoprotein-releasing system transmembrane protein LolC/E + Protein of unknown function DUF2304 + Protein of unknown function DUF2125 + NADH-quinone oxidoreductase, chain I + 3-oxoacid CoA-transferase, subunit B + Methenyltetrahydromethanopterin cyclohydrolase + KTSC domain + DNA polymerase II large subunit DP2, N-terminal + Carbamate kinase + Glycosyl-hydrolase 97, C-terminal oligomerisation domain + Putative antitoxin + DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site + Domain of unknown function DUF3971 + L-2-Haloacid dehalogenase + Chaperonin TCP-1, conserved site + Quinone oxidoreductase/zeta-crystallin, conserved site + Pyruvate-flavodoxin oxidoreductase + Cdc6, C-terminal + Biotin synthase/Biotin biosynthesis bifunctional protein BioAB + SUF system FeS cluster assembly, SufB + Type 4 fimbrial biogenesis protein PilX, N-terminal domain + Polyribonucleotide 5'-hydroxyl-kinase Clp1, P-loop domain + Archaeophage PsiM2, terminase large subunit + PH domain-like + Large-conductance mechanosensitive channel, conserved site + Stress responsive alpha-beta barrel + Zinc ribbon, NADH pyrophosphatase + Sirohaem synthase, dimerisation domain + Protein of unknown function DUF2219 + Domain of unknown function DUF815 + Protein of unknown function DUF938 + 5,10-methylenetetrahydrofolate reductase + RTX toxin determinant A + Putative GTP-binding controlling metal-binding domain + Ferredoxin, C-terminal + Asparaginase/glutaminase, active site 2 + Molybdate ABC transporter, permease protein + Protein of unknown function DUF1285, beta-roll domain + CpXC domain + Primase, C-terminal 2 + DNA gyrase inhibitor YacG + Flagellar assembly protein FliH/Type III secretion system HrpE + Type VI secretion protein, EvpB/VC_A0108, tail sheath + tRNA-hydroxylase MiaE + Protein of unknown function DUF1289 + YgfZ/GcvT conserved site + 1-acyl-sn-glycerol-3-phosphate acyltransferase + MoaD, archaeal-type + A/G-specific adenine glycosylase MutY + Lipoprotein SmpA/OmlA + Glycoside hydrolase family 65, C-terminal + ATP synthase protein I + ATP:guanido phosphotransferase, catalytic domain + Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family + 6-phosphogluconolactonase, DevB-type + Diacylglycerol glucosyltransferase, N-terminal + FMN-dependent alpha-hydroxy acid dehydrogenase, active site + Domain of unknown function DUF374 + Phage terminase large subunit, C-terminal + Na/Pi-cotransporter II-related/YqeW-like protein + Membrane complex biogenesis protein, BtpA family + Domain of unknown function DUF1549 + Jann4075-like domain + Probable chaperone CsaA + Protein of unknown function DUF2065 + Peptidase S46 + Protein of unknown function DUF2853 + Conserved hypothetical protein CHP02453 + UPF0014 family + RNA helicase HrpA, C-terminal + Alginate lyase domain + Cobyrinic acid a,c-diamide synthase CbiA + UDP-GlcNAc diphosphorylase/GlcNAc-1-P N-acetyltransferase, GlmU, bacterial-type + Protein of unknown function DUF3179 + Protein of unknown function DUF4238 + Protein of unknown function DUF92, TMEM19 + TPMT family + Helicase Helix-turn-helix domain + Concentrative nucleoside transporter N-terminal domain + Phosphorylase pyridoxal-phosphate attachment site + Macrocin-O-methyltransferase + Ubiquinol-cytochrome c reductase, iron-sulphur subunit + eRF1 domain 1/Pelota-like + Alpha-1,2-mannosidase, putative + Hydroxyacylglutathione hydrolase + Cobalt-precorrin-5B C(1)-methyltransferase CbiD + Phage tail collar domain + Cof family + Protein of unknown function DUF1538 + Phytase-like domain + Phosphoglycerate mutase 1 + Citrate synthase, type I + Peptidase S1A, chymotrypsin family + Domain of unknown function DUF5110 + Heat shock protein Hsp33, helix hairpin bin domain + Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y + Cytochrome P450, E-class, group I + DNA helicase Pif1-like + Homogentisate 1,2-dioxygenase + Protein of unknown function DUF2339, transmembrane + HEAT repeat + Glycosyl transferase, family 25 + PrkA AAA domain + Spermidine/putrescine ABC transporter, ATP-binding subunit + Protein of unknown function DUF882 + Chemoreceptor glutamine deamidase CheD + CDC48, domain 2 + RNA 3'-terminal phosphate cyclase type 1 + Urease alpha-subunit, N-terminal domain + Protein of unknown function DUF1302 + Protein of unknown function DUF166 + Protein of unknown function DUF211 + Transcription termination factor NusA, C-terminal duplication + Domain of unknown function DUF3343 + Predicted integral membrane protein DUF2189 + Transcription factor TFIIB, conserved site + Protein of unknown function DUF839 + Hydroxylamine reductase + Tetratricopeptide TPR-4 + Ornithine decarboxylase + Amino acid/polyamine transporter 2 + Esterase, PHB depolymerase + Domain of unknown function DUF403 + Phospholipase C/P1 nuclease domain + Bacterial Pleckstrin homology domain-related + Uncharacterised conserved protein UCP028069 + Glutaredoxin, GrxC + Autotransporter beta-domain + Sarcosine oxidase, gamma subunit + Protein of unknown function DUF4252 + Domain of unknown function DUF1858 + IMP dehydrogenase-related 2 + Beta propeller domain-containing family + Glycoside hydrolase, family 2, conserved site + Domain of unknown function DUF4994 + Disaggregatase-related repeat + Adrenodoxin, iron-sulphur binding site + Band 7/stomatin-like, conserved site + DivIVA domain + Hypothetical glycosyl hydrolase 6 + Alginate export domain + Membrane fusogenic activity + Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO + PocR domain + Domain of unknown function DUF1731 + Gas vesicle protein GvpA, conserved site + Putative DNA-binding domain, bacteria + Protein of unknown function DUF2797 + Primase, C-terminal 1 + Di-haem oxidoreductase, putative peroxidase + C4-dicarboxylate anaerobic carrier-like + C-type polyheme cytochrome OmcB + Protein of unknown function DUF4230 + Cytochrome c-type biogenesis protein CcmI + Gas vesicle protein GvpL/GvpF + Glucosamine-6-phosphate isomerase + Aspartate/other aminotransferase + D-glucuronyl C5-epimerase + Domain of unknown function DUF4105 + RepB plasmid partition + Hydantoinase/dihydropyrimidinase + Ribonuclease R + Tim44-like domain + Isopentenyl-diphosphate delta-isomerase, FMN-dependent + CRISPR-associated protein, Csd1-type + Initiation factor 2 associated domain, bacterial + WG containing repeat + Ribosomal protein S6, conserved site + Domain of unknown function DUF1989 + Phosphopentomutase + Domain of unknown function DUF4157 + Protein arginine methyltransferase NDUFAF7 + Protein of unknown function DUF952 + Protein of unknown function DUF4013 + Dimethylamine methyltransferase MtbB + GrpB/Dephospho-CoA kinase + Short chain fatty acid transporter AtoE + Bacterial mobilisation + Flagellar basal-body rod protein FlgB + TrkH potassium transport family + Arginine-tRNA-protein transferase, N-terminal + Pyridoxal phosphate phosphatase-related + Iron sulphur-containing domain, CDGSH-type + KDPG/KHG aldolase, active site 1 + Polyketide synthase, dehydratase domain + Ribokinase + Lipid A 3-O-deacylase-related + Putative C-S lyase + Nickel-dependent hydrogenase b-type cytochrome subunit + Lysine-2,3-aminomutase, C-terminal domain + Putative nucleotide-binding C-terminal domain + Periplasmic protein thiol:disulphide oxidoreductase DsbE + Bacteriophage SPP1, head-tail adaptor + Polyketide synthase, ketoreductase domain + Bacteriophage T5, Orf172 DNA-binding + LicD family + Proprotein convertase, P + Cell surface SprA + NADH pyrophosphatase-like, N-terminal + Methylmalonate-semialdehyde dehydrogenase + Protein of unknown function DUF1800 + ATPase, type III secretion system, FliI/YscN + 3-isopropylmalate dehydratase, large subunit, bacteria + Cation efflux system CzcA/CusA/SilA/NccA/HelA/CnrA + Glycoside hydrolase family 18, catalytic domain + Uncharacterised protein family UPF0272 + Transcription regulator YcdC, C-terminal + Extensin-like, C-terminal + Nitrile hydratase alpha /Thiocyanate hydrolase gamma + Tol-Pal system, TolQ + Anthranilate synthase component I, PabB-like + Uridine kinase-like + Peptidase M10 serralysin, C-terminal + Scaffold protein Nfu/NifU, N-terminal + GSCFA + Solute-binding family 1, conserved site + Multicopper oxidase, type 2 + Ornithine aminotransferase + Anti-sigma-28 factor, FlgM + Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase + Glycoside hydrolase family 9 + Protein of unknown function DUF2232 + Gas vesicle protein GvpA + Domain of unknown function DUF2329 + Cytochrome c oxidase assembly protein CtaG/Cox11, domain + Uncharacterised protein family, glycosyl hydrolase catalytic domain + Domain of unknown function DUF4412 + Putative manganese efflux pump + 6-phosphogluconate-binding site + CobE/GbiG C-terminal domain + IMP biosynthesis enzyme PurP, C-terminal + ATP-dependent RNA helicase HrpB, C-terminal + Domain of unknown function DUF3333 + Amidase, carbamoylase-type + Flavinator of succinate dehydrogenase + Restriction endonuclease, type II, MjaI + Protein of unknown function DUF2752 + RNA methyltransferase TrmH, group 1 + Uracil-DNA glycosylase family 1 + SprT-like + Glycoside hydrolase, family 39 + Oxygen-independent coproporphyrinogen III oxidase HemN + Anti-sigma-28 factor FlgM, C-terminal + Protein of unknown function DUF1848 + Bacterioferritin + Protein of unknown function DUF5317 + Ferrochelatase, active site + Bacteriophage phiKZ, Orf197 + Na(+)-translocating NADH-quinone reductase subunit A, C-terminal domain + YaeQ + Flagellar protein FliS + Nucleoid-associated protein NdpA + Sulphate adenylyltransferase, large subunit + Multicopper oxidase, type 3 + Protein of unknown function DUF1704 + SMc04008-like domain + Ribosomal protein S1 + Flagellar basal-body rod FlgG + Putative rhamnosyl transferase + CRISPR-associated protein Cas8b + Urate oxidase N-terminal + Protein of unknown function DUF1178 + Cytochrome c oxidase assembly protein CtaG/Cox11 + Integral membrane protein TerC + CDP-diacylglycerol--serine O-phosphatidyltransferase + Glutaminase + Orc1/Cdc6-type DNA replication protein, archaea + PHB de-polymerase, C-terminal + Glutathione peroxidase active site + Uncharacterised protein family UPF0250 + Double Cache domain 3 + DNA-binding protein Dps + Cytochrome c oxidase cbb3-type, subunit III + Domain of unknown function DUF4430 + Flagellar biosynthesis protein, FliO + Peptidase M15B + Peptidase M13, N-terminal domain + Conserved hypothetical protein CHP02241 + Proline dehydrogenase PutA, domain II + Dihydrolipoamide succinyltransferase + Cytochrome C oxidase subunit IV, prokaryotes + Nicotinamide mononucleotide transporter PnuC + Bacteriophage lambda, GpH, tail tape measure, C-terminal + 5'(3')-deoxyribonucleotidase + Protein of unknown function DUF4446 + Pyrimidine 5-nucleotidase + Conserved hypothetical protein CHP02001 + Butirosin biosynthesis protein H, N-terminal + Uncharacterised protein family UPF0149 + Uncharacterised conserved protein UCP030820 + Toxic anion resistance + Protein of unknown function DUF1593 + Protein of unknown function DUF1064 + Oligosaccharide biosynthesis protein Alg14-like + Thiamin/hydroxymethyl pyrimidine-binding YkoF, putative + Domain of unknown function DUF4126 + Pilus assembly protein PilP + Peptidase M24, C-terminal domain + Aconitase B, HEAT-like domain + DNA-directed DNA polymerase, family B + Peptidase C70, AvrRpt2 + RNA polymerase sigma factor, FliA/WhiG + Autoinducer synthase + Winged helix DNA-binding domain + RarD protein + IstB-like ATP binding N-terminal + Gliding motility protein SprA N-terminal domain + Sodium:dicarboxylate symporter, conserved site + Non-haem dioxygenase N-terminal domain + Uncharacterised conserved protein UCP033101 + Cobalamin (vitamin B12) biosynthesis CbiE, precorrin-6Y methyltransferase + Peptidase S33 tripeptidyl aminopeptidase-like, C-terminal + Protein YhcC-like + Host attachment protein + Integration host factor, beta subunit + Lysine-tRNA ligase + ComB-like + RNA polymerase sigma-70 ECF-like + Protein of unknown function DUF1223 + Domain of unknown function DUF4384 + DNA ligase, OB-like domain + Nitrile hydratase beta subunit domain + Nitrous oxide reductase accessory protein NosL + CDP-archaeol synthase + Uncharacterised peroxidase-related + Glucose-1-phosphate adenylyltransferase + ATP-citrate synthase, citrate-binding domain + Phage major tail protein TP901-1 + Peroxidase, active site + Nitrite reductase [NAD(P)H] small subunit, NirD + NIPSNAP + Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase + Vanillyl-alcohol oxidase/Cytokinin dehydrogenase C-terminal domain + Flagellar export FliJ + Peptide chain release factor 3 + Cytochrome c oxidase, subunit II + Na(+)-translocating NADH-quinone reductase subunit F + Virulence-associated E + Transport and Golgi organisation protein 2 + DMSO reductase anchor subunit (DmsC) + Sarcosine oxidase, delta subunit, heterotetrameric + Transcription regulator PadR, C-terminal + Sporulation protein YtfJ + Carbon monoxide dehydrogenase subunit G + Protein of unknown function DUF2204 + Dockerin type I repeat + Reductase, C-terminal + Purine nucleoside phosphorylase DeoD-type + MetA family + D-lyxose isomerase + SlyX + Sulphur relay, TusB/DsrH + Alcohol dehydrogenase, zinc-binding type 2 + Protein of unknown function DUF1643 + Glycoside hydrolase family 1, active site + Coenzyme A transferase binding site + Adenylyl cyclase CyaB + Protein of unknown function DUF4837 + Cytochrome c oxidase cbb3-type, subunit I + Tail specific protease, C-terminal + PepSY domain + Tetrapyrrole biosynthesis, glutamate-1-semialdehyde aminotransferase + Azospirillum phage Cd, Gp10 + Hydroxyethylthiazole kinase + Uncharacterised protein family UPF0158 + DNA-binding domain, IS481-type + Polysaccharide lyase + Abortive infection system protein AbiD/AbiF-like + Domain of unknown function DUF4325 + Protein of unknown function DUF3344 + Glycosyl hydrolase family 99 + Replication factor C, C-terminal + Molybdenum-pterin binding + Bacteriophage KVP40, Orf299 + Protein of unknown function DUF4442 + Intradiol ring-cleavage dioxygenase, C-terminal + Urease accessory protein UreD + Uncharacterised MFS-type transporter YbfB + Cell wall-active antibiotics response 4TMS YvqF + Glyoxalase-like domain + YheO-like + Bacterial Pleckstrin homology domain + YopX-like domain, beta barrel type + Conserved hypothetical protein CHP03663 + Peptidase M16C associated + Heme-NO binding + CRISPR-associated protein Cse1 + Transcriptional coactivator p15 (PC4) + Domain of unknown function DUF2126 + Domain of unknown function DUF4953 + Domain of unknown function DUF1738 + Transposase, IS1 + Integration host factor, alpha subunit + Abortive infection protein-like, C-terminal domain + Na(+)-translocating NADH-quinone reductase subunit C + Alpha-glucosidase, domain of unknown function DUF4968 + Molybdopterin converting factor, subunit 1 + Bacterial transglutaminase-like, N-terminal + Molybdenum cofactor biosynthesis protein B, proteobacteria + Transthyretin/hydroxyisourate hydrolase, superfamily + Conserved hypothetical protein CHP03980, redox-disulphide + Predicted 3'-5' exonuclease, PolB-like + Circularly permuted ATP-grasp type 2 + Resuscitation-promoting factor, domain of unknown function DUF348 + DNA polymerase 3, epsilon subunit + ApaG domain + Uncharacterised protein family UPF0164 + Succinate dehydrogenase, cytochrome b subunit, conserved site + Cytochrome b5-like heme/steroid binding domain + 2-keto-3-deoxy-galactonokinase + YtoQ family protein + RRXRR domain + 2-oxoglutarate dehydrogenase E1 component + Class III cytochrome C + Peptidase C15, pyroglutamyl peptidase I-like + Cobalt chelatase, CobT subunit + Beta-galactosidase, domain 4 + DHAP synthase, class 1 + Magnesium/cobalt transport protein CorA + Peptidase S12, Pab87-related, C-terminal + RLI1 + Uncharacterised protein family, zinc metallopeptidase putative + Uncharacterised protein family UPF0227/Esterase YqiA + Conserved hypothetical protein CHP02466 + FlgN-like protein + Undecaprenyl-phosphate glucose phosphotransferase, WcaJ + Tryptophan 2,3-dioxygenase + Dihydroxyacetone kinase, subunit L + Tol-Pal system beta propeller repeat-containing protein, TolB + Ribosome biogenesis GTPase RsgA, N-terminal + NlpC/P60 family, putative phage cell wall peptidase + Leucine rich repeat 5 + Transposase, Tn5-like, C-terminal + Cryptochrome/DNA photolyase class 1, conserved site, C-terminal + Aspartate carbamoyltransferase regulatory subunit, N-terminal + Bacterial Ig-like domain + Sec-independent periplasmic protein translocase, conserved site + Methyl-accepting chemotaxis protein, four helix bundle domain + Ribosomal RNA aminoglycoside-resistance methyltransferase + Domain of unknown function DUF4113 + CidB/LrgB family + Peptidase M20B, tripeptide aminopeptidase + Urease accessory protein UreF + Putative beta-barrel porin 2 + Phage gp6-like head-tail connector protein + EfeO-type cupredoxin-like domain + DNA primase, small subunit + Methyltransferase cognate corrinoid protein + RfaE bifunctional protein, domain II + Exodeoxyribonuclease I, C-terminal + Domain of unknown function DUF4392 + LPS export ABC transporter permease LptG + O-acetylhomoserine/O-acetylserine sulfhydrylase + Galactose-1-phosphate uridyl transferase, class I His-active site + Phage conserved hypothetical protein + Coenzyme F420:L-glutamate ligase + Para-aminobenzoate synthase, component I + Polyphosphate:nucleotide phosphotransferase, PPK2 + Protein of unknown function DUF4242 + Bacteriophage VT1-Sakai, H0018 + Urease, alpha subunit + Protein of unknown function DUF520 + RNA polymerase sigma factor RpoH, proteobacteria + SH3 domain protein + Toxin-antitoxin system, toxin component, HigB, putative + Uncharacterised protein family UPF0029, Impact, conserved site + DNA-binding protein Dps, conserved site + Fimbrial protein pilin + Hypothetical PA1492 domain + Ketoacyl-synthetase, C-terminal extension + Cell division topological specificity factor MinE + Gdt1 family + Proliferating cell nuclear antigen, PCNA, N-terminal + Ring-hydroxylating dioxygenase beta subunit + Aspartate--ammonia ligase + Precorrin-6x reductase + Histone deacetylase + GPI inositol-deacylase PGAP1-like + Peptidoglycan binding domain + GcrA cell cycle regulator + Fumarylacetoacetase, N-terminal + Signal transduction response regulator, phosphate regulon transcriptional regulatory protein PhoB + Capsule assembly protein Wzi + Transcriptional regulator PAI 2-type + HYR domain + ADP-heptose--LPS heptosyltransferase 2 + Orthogonal Bundle domain in ATP12 + Eukaryotic molybdopterin oxidoreductase + Peptidase M74, penicillin-insensitive murein endopeptidase + Delta-60 repeat + ABC-type thiamin-related transport system, permease component 1, predicted + Domain of unknown function DUF1456 + L-asparaginase, type I + Domain of unknown function DUF512 + Nickel/cobalt transporter, high-affinity + Phosphate-starvation-induced PsiE-like + RNA-binding, CRM domain + Protein of unknown function DUF1007 + Sodium/glutamate symport carrier protein GltS + Acyl carrier protein phosphodiesterase + Adenosylcobinamide amidohydrolase, CbiZ + Acetylornithine deacetylase ArgE + AttH domain + Hydrophobe/amphiphile efflux-1 HAE1 + Iron-sulphur-dependent L-serine dehydratase single chain form + Signal peptide, camelysin + Zinc finger, DksA/TraR C4-type, bacteria + Zona occludens toxin + Peptidase M1, alanyl aminopeptidase + 4-hydroxybenzoate polyprenyltransferase + Penicillin-binding protein activator LpoB + NB-ARC + Putative metal-binding domain of cation transport ATPase + TonB-dependent siderophore receptor + Biopolymer transport, TolR + YopX protein + Pyruvoyl-dependent arginine decarboxylase + Autotransporter-associated beta strand repeat + Moybdenum cofactor oxidoreductase, dimerisation + CHAP domain + Glutamine synthetase class-I, adenylation site + FO synthase, subunit 2 + Catalase immune-responsive domain + Type II secretion system protein J + HIRAN domain + Epimerase family protein SDR39U1 + Phosphoribosylaminoimidazole carboxylase, ATPase subunit + PrkA C-terminal domain + Protein of unknown function DUF4197 + Uncharacterised protein family PrgI + Septum formation inhibitor MinC, C-terminal + Anaerobic sulphatase maturase, radical SAM + Riboflavin kinase domain, CTP-dependent + 3-isopropylmalate dehydratase, large subunit + Haem exporter protein D (CcmD) + Adenine-specific methylase EcoRI + 3-dehydroquinate synthase + Bacteriophage Mu, GpT + Tellurite resistance methyltransferase TehB-like domain + Putative quorum-sensing-regulated virulence factor + Protein of unknown function DUF2721 + Glucokinase regulatory protein, conserved site + Prohibitin + Catalase active site + Pyruvoyl-dependent histidine/arginine decarboxylase, 3-layer sandwich domain + RNase L inhibitor RLI, possible metal-binding domain + Pectinesterase, catalytic + Protein of unknown function DUF4263 + Pheromone shutdown, TraB, bacterial/archaeal + FlaG protein + Protein of unknown function DUF455 + Phosphohistidine phosphatase SixA + Protein of unknown function DUF2267 + Invasion protein B + Gtr1/RagA G protein + Protein of unknown function DUF333 + Na(+)-translocating NADH-quinone reductase subunit D + Outer membrane autotransporter barrel + Tetrahydromethanopterin S-methyltransferase, subunit H/Methyltransferase Mtx, subunit H + Protein of unknown function DUF2254, membrane + CRISPR-associated protein, CT1975 + Harbinger transposase-derived nuclease domain + TspO/MBR-related protein + ThiC-associated domain + Phosphoenolpyruvate carboxykinase (ATP), conserved site + Luciferase family oxidoreductase, group 1 + Protein of unknown function DUF5309 + Glutathione synthetase, prokaryotic + Glucose-1-phosphate cytidylyltransferase + Erythromycin esterase + ATP binding protein MinD, bacterial-type + Diaminopimelate aminotransferase, DapL, Desulfovibrio-type + Thiamine-phosphate synthase ThiN + Urease, beta subunit + DNA/RNA-binding protein Alba + Peptidase C10, streptopain + Methyltransferase type 12 + Endonuclease MutS2 + Putative condensing enzyme FabH-related + ABC transporter, ATPase, putative + RecB family nuclease, TM0106, putative + Domain of unknown function DUF438 + Ribosomal RNA large subunit methyltransferase F-like + Copper homeostasis CutC domain + DNA helicase, RecD-like + Domain of unknown function DUF1611, P-loop + Head-to-tail connector protein, podovirus-type + Glutamine synthetase type III N-terminal + Biosynthetic peptidoglycan transglycosylase + Protein of unknown function DUF2490 + MOSC, N-terminal beta barrel + AbrB family + Protein of unknown function DUF349 + Aromatic amino acid hydroxylase + Formate dehydrogenase accessory protein + 2-phospho-L-lactate guanylyltransferase, CofC + Fibrillarin + Bacterial microcompartments protein, conserved site + Na(+)-translocating NADH-quinone reductase subunit E + Iron hydrogenase, small subunit + Aspartate-tRNA synthetase, type 2 + Cell division protein SepF/SepF-related + Putative ATP-binding cassette + IMP biosynthesis enzyme PurP, N-terminal + Abhydrolase, bacterial + UPF0234 N-terminal domain + Urease, gamma/gamma-beta subunit + Competence protein ComEC/Rec2 + GTP binding protein, second domain + Protein of unknown function DUF1631 + Bacillithiol biosynthesis BshC + PAAR motif + Domain of unknown function DUF4365 + Lipocalin-like domain + MTA/SAH nucleosidase + Bifunctional uridylyltransferase/uridylyl-removing enzyme + 2-amino-3-ketobutyrate coenzyme A ligase + Protein of unknown function DUF1365 + Phosphotransferase system, sorbose subfamily IIB component + Protein of unknown function DUF4202 + Thiosulfate oxidation carrier complex protein SoxZ + Protein of unknown function DUF3592 + Ribosomal RNA small subunit methyltransferase J + Acyl-ACP thioesterase + PhoR, single Cache-like domain + DNA primase large subunit, eukaryotic/archaeal + Protein of unknown function DUF2244, transmembrane + Methyltransferase Ppm1/Ppm2/Tcmp + TATA-box binding protein, conserved site + Protein of unknown function DUF937 + Branched-chain amino acid aminotransferase II + DNA-3-methyladenine glycosylase I + MltA-interacting MipA + Succinate dehydrogenase/fumarate reductase, flavoprotein subunit + Hemimethylated DNA-binding domain + Transcription regulator HTH, AraC, N-terminal + Protein of unknown function DUF1850 + Tail sheath protein, subtilisin-like domain + Phosphoglucosamine mutase, archaeal type + Protein of unknown function DUF2948 + PaaX-like, N-terminal + DNA topoisomerase I, catalytic core, eukaryotic-type + Domain of unknown function DUF427 + Secretion protein HlyD, conserved site + Transferase 2, rSAM/selenodomain-associated + Cupin domain of unknown function DUF985 + Nucleotidyltransferase 8 + Sulphate adenylyltransferase, small subunit + K+/H+ exchanger + Domain of unknown function DUF4190 + Aspartate dehydrogenase + Aconitase, putative + Tail sheath protein, C-terminal domain + Zinc finger, RanBP2-type + Protein of unknown function DUF1153 + Lipopolysaccharide export system protein LptA + Cytochrome C, Planctomycete + Ribonuclease Z/BN + Fatty acid cis-trans isomerase + Ubiquitin Mut7-C domain + Peptidase M10, metallopeptidase + Protein of unknown function DUF5305 + 7TM-DISM receptor, extracellular domain, type 2 + Aspartate-semialdehyde dehydrogenase, peptidoglycan lacking + Protein of unknown function DUF4292 + Ubiquinone biosynthesis protein Coq7 + Thymidylate synthase, active site + SUF system FeS cluster assembly, SufD + Glycogen debranching enzyme, bacterial and archaeal type, N-terminal + Uncharacterised protein family UPF0313 + Acrylyl-CoA reductase AcuI + Pseudouridine synthase TruD, conserved site + Penicillin-binding protein activator LpoA + Lipase, GDXG, putative histidine active site + Thioesterase + Phosphate acetyltransferase + PhnA protein, N-terminal + Protein of unknown function DUF2958 + Mannitol dehydrogenase + Uncharacterised conserved protein UCP020606 + Glycerate kinase, restriction-enzyme-like fold + Restriction endonuclease, type II, NotI + Histidinol phosphate phosphatase, HisJ + Alkyl sulfatase dimerisation domain + Domain of unknown function DUF4140 + RIO kinase, conserved site + Male sterility, NAD-binding + Queuosine precursor transporter QueT + Sodium/solute symporter, VC2705 subfamily + Uncharacterised conserved protein UCP032025 + Protein of unknown function DUF4954 + Phosphate propanoyltransferase + Protein of unknown function DUF2914 + Extradiol ring-cleavage dioxygenase LigAB, LigA subunit + Ribosomal RNA large subunit methyltransferase J + Domain of unknown function DUF4872 + Proliferating cell nuclear antigen, PCNA, C-terminal + Protein of unknown function DUF962 + Peptidase S10, serine carboxypeptidase + Type II secretion system, protein M + Transthyretin, thyroxine binding site + Transposase, Tn5-like, N-terminal + Protein of unknown function DUF4391 + S-layer family duplication domain + Big-1 (bacterial Ig-like domain 1) domain + p-Aminobenzoyl-glutamate transport protein AbgT + Abortive infection protein, AbiV family + Protein of unknown function DUF1287 + PHB accumulation regulatory + TniQ + Phosphotransferase system, IIA component fructose subfamily + YqaJ viral recombinase + DNA/RNA non-specific endonuclease + Glutamate--cysteine ligase + TIM-barrel domain, IGPS-like + Flagellar motor switch FliN + UPF0234/UPF0381 domain + Pyrimidine/purine nucleoside phosphorylase + Catalase haem-binding site + YidE/YbjL duplication + Ribonuclease T2-like + Cysteine-rich CPXCG protein + ZipA, C-terminal FtsZ-binding domain + Domain of unknown function DUF1828 + Isocitrate lyase + UDP-GlcNAc diphosphorylase/GlcNAc-1-P N-acetyltransferase, GlmU, archaeal-type + Putative metallopeptidase domain + Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA + Uncharacterised domain UPF0029, Impact, C-terminal + Alginate lyase 2 + ADF-H/Gelsolin-like domain + Protein of unknown function DUF2282, integral membrane + Alpha-acetolactate decarboxylase + ATPase MipZ + LTXXQ motif family protein + Restriction endonuclease, type II, BsuBI/PstI, C-terminal + Arginine decarboxylase + ATP12, ATP synthase F1-assembly protein + Alpha-amylase/4-alpha-glucanotransferase, C-terminal + Protein of unknown function DUF2130 + Amino acid synthesis, putative + Glutaredoxin-like domain + Ribbon-helix-helix domain + Uncharacterised conserved protein UCP032146 + Zinc-ribbon containing domain + NarX-like, N-terminal + Protein of unknown function DUF2804 + AAA ATPase, CDC48 family + Methyltransferase putative zinc binding domain + KipI family + Ribonucleotide reductase, class I , alpha subunit + Tail protein I + DNA topoisomerase VI, subunit B, transducer + Cobalamin biosynthesis, precorrin-6Y methyltransferase, CbiT subunit + Carbohydrate-selective porin OprB + Biotin-protein ligase, N-terminal + Aromatic-ring-hydroxylating dioxygenase, 2Fe-2S-binding site + Adenosylmethionine--8-amino-7-oxononanoate aminotransferase BioA + Protein of unknown function DUF3488 + VPLPA-CTERM protein sorting domain + tRNA sulfurtransferase ThiI + Holliday junction resolvase-related domain + Peptidase M73, camelysin + 4-hydroxybenzoyl-CoA thioesterase, active site + Cobalamin biosynthesis protein CobT VWA domain + Domain of unknown function DUF4832 + Thiol peroxidase conserved site + Alpha glucuronidase, N-terminal + Disaggregatase-related + Type IV pilus secretin PilQ + LrgA/CidA family + ABC transporter phosphate permease PstC, N-terminal domain + Type VI secretion system, VipA, VC_A0107 or Hcp2 + Type VI secretion system, TssF-like + Protein of unknown function DUF3127 + Tyrosine recombinase XerC + Ribonuclease D + Chemoreceptor zinc-binding domain + Choloylglycine hydrolase/NAAA C-terminal + Methylguanine DNA methyltransferase, ribonuclease-like domain + D-alanyl-D-alanine dipeptidase + Cytochrome c-type biogenesis protein CcmB, bacteria + Protein of unknown function DUF3520 + Bacterial Ig-like domain (group 3) + Domain of unknown function DUF402 + Succinyl-diaminopimelate desuccinylase, proteobacteria + Glycosyl hydrolase, family 88 + Protein of unknown function (DUF4381 + Group 4 capsule polysaccharide formation lipoprotein GfcB + Polyamine biosynthesis domain, conserved site + Domain of unknown function DUF2726 + Domain of unknown function DUF1592 + CbxX/CfqX + Isocitrate lyase/phosphorylmutase, conserved site + Uncharacterised protein YfbK, N-terminal + ATP-dependent Clp protease ATP-binding subunit ClpA + Aminoglycoside 6-adenylyltransferase + Ribonucleotide reductase class II vitamin B12-dependent, N-terminal domain + Cobalamin synthesis G, N-terminal + NifH/chlL conserved site + 4-hydroxyphenylpyruvate dioxygenase + Non-canonical purine NTP phosphatase + ABC transporter, ATP-binding protein, ChvD + Cobalamin-independent methionine synthase MetE, N-terminal + NADH dehydrogenase ubiquinone Fe-S protein 4, mitochondrial + Chemotaxis phosphatase CheX-like domain + MIT, C-terminal phospholipase D-like domain + Sucrose-phosphatase-like, N-terminal + Kinesin light chain + Abnormal spindle-like microcephaly-associated protein, ASH domain + Dihydrofolate reductase conserved site + CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit + Protein of unknown function DUF2237 + Membrane dipeptidase, active site + ParD-like antitoxin of type II bacterial toxin-antitoxin system + Flagellar biosynthesis protein FliQ + O-phosphoseryl-tRNA:Cys-tRNA synthase, archaea + Cytochrome c, class IE + Protein of unknown function DUF2155 + NmrA-like domain + Acetoacetate decarboxylase beta barrel domain + YmcC-like domain + Kynureninase + Sporulation stage V, protein R + Conserved hypothetical protein CHP02186-related, transmembrane + Galactosyltransferase, C-terminal + PDGLE domain + UreE urease accessory, N-terminal + Putative porin-10 + Protein of unknown function DUF2794 + Glycine dehydrogenase (decarboxylating) + Peptidase M3B, oligoendopeptidase-related clade 3 + (2R)-phospho-3-sulpholactate synthase, ComA + Protein of unknown function DUF1457 + LPS export ABC transporter permease LptF + Geranylgeranylglyceryl phosphate synthase + Glycoside hydrolase, family 27 + S-formylglutathione hydrolase + Domain of unknown function DUF5117 + Hypoxia induced protein, domain + Acetoacetyl-CoA reductase + Beta-lactamase, class-B, conserved site + Pyridoxal-phosphate binding site + Inositolphosphotransferase Aur1/Ipt1 + Type II secretion system GspE + Ribonuclease HII, helix-loop-helix cap domain + CheC-like protein + Antitoxin MqsA/HigA-2 + Protein of unknown function DUF3078 + Urease accessory protein UreE, C-terminal domain + Dihydroorotase homodimeric type + NTF2-like N-terminal transpeptidase + Histone-like protein H-NS + Protein of unknown function DUF655 + Cobalamin (vitamin B12) biosynthesis CobM/CbiF, precorrin-4 C11-methyltransferase + NADH:ubiquinone oxidoreductase intermediate-associated protein 30 + Histidine-specific methyltransferase, SAM-dependent + Lipocalin/cytosolic fatty-acid binding domain + Archaeal Nre, N-terminal + Thermonuclease active site + DNA topoisomerase VI, subunit A + tRNA methyltransferase, Trm1 + Alcohol dehydrogenase class III + Bromoperoxidase/chloroperoxidase, C-terminal + Ubiquitin-conjugating enzyme/RWD-like + Putative bacterial porin + Transcriptional regulator Spx/MgsR + Putative exonuclease, RdgC + Phosphonate metabolism protein PhnI + Protein of unknown function DUF1073 + Phosphatidylglycerol lysyltransferase, C-terminal + Zinc finger, CHCC-type + Domain of unknown function DUF418 + Chemotaxis phosphatase, CheZ + 2-phosphoglycolate phosphatase, prokaryotic + HPr(Ser) kinase/phosphorylase, N-terminal + DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type + Antitoxin MqsA + Domain of unknown function DUF4010 + WGR domain + Flagellar biosynthesis protein FlhA + Cobaltochelatase subunit CobS N-terminal domain + Ribosomal protein L37ae/L37e + Hydroxyisourate hydrolase + Xanthine dehydrogenase accessory protein XdhC + Polyhydroxyalkanoate synthesis repressor PhaR + KilA, N-terminal/APSES-type HTH, DNA-binding + Tyrosine/serine-protein phosphatase IphP-type + Methylglyoxal synthase + Protein of unknown function DUF4926 + 2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate + Protein of unknown function DUF1476 + PQ-loop repeat + RfaE bifunctional protein, domain I + Sodium:galactoside symporter, conserved site + PDCD5-related protein + Domain of unknown function DUF4185 + PRD domain + Beta propeller repeat, Msarc-type + Head domain of trimeric autotransporter adhesin + Multicopper oxidase, type 1 + VWA-like domain + Gp5 N-terminal + NADH:ubiquinone oxidoreductase chain 4, N-terminal + Zinc finger, AN1-type + UDP-galactopyranose mutase, C-terminal + Uncharacterised protein family YdfA-immunity + Proteasome alpha-subunit, N-terminal domain + SecD export protein N-terminal TM domain + Urease accessory protein UreG + Domain of unknown function DUF4172 + Spo11/DNA topoisomerase VI, subunit A, N-terminal + Homoserine kinase + PhoPQ-activated pathogenicity-related protein, PqaA type + ATPase, type I secretion system, PrtD + Uncharacterised protein family YgbA + Domain of unknown function DUF4357 + Tol-Pal system-associated acyl-CoA thioesterase + Protein of unknown function DUF1761 + CDP-glucose 4,6-dehydratase + Protein of unknown function DUF47 + Type IV secretion system, VirB10 / TraB / TrbI + Probable phospholipid ABC transporter-binding protein MlaD + Protein of unknown function DUF3426 + Protein of unknown function DUF1275 + Quinone oxidoreductase PIG3 + Gluconate 2-dehydrogenase subunit 3 + YhcH/YjgK/YiaL family + Phosphoribulokinase + Protein of unknown function DUF3572 + Nitrate/nitrite sensing protein + Protein of unknown function DUF447 + L-rhamnose-proton symport, RhaT + Ammonium transporter, marine subtype + Proteolipid membrane potential modulator + Ni-containing CO dehydrogenase + DNA polymerase III, subunit gamma/ tau, C-terminal + BAAT/Acyl-CoA thioester hydrolase C-terminal + Protein of unknown function DUF1013 + Drug resistance transporter EmrB/QacA subfamily + Peptidyl-tRNA hydrolase II domain + Domain of unknown function DUF971 + Superoxide dismutase, copper/zinc binding domain + Uncharacterised protein family UPF0114 + Spo11/DNA topoisomerase VI subunit A + Ribosomal protein L31e domain + Ferredoxin thioredoxin reductase catalytic beta subunit + FHIPEP conserved site + DTW + Acyl-CoA dehydrogenase, C-termina, bacterial type + CsbD-like domain + Ta0600-like domain + Periplasmic pectate lyase + Ribonuclease P/MRP, subunit p29 + Phospholipase D, N-terminal + Domain of unknown function DUF3887 + NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 + Na(+)-translocating NADH-quinone reductase subunit B + Campylobacter phage CGC-2007, Cje0229 + Domain of unknown function DUF4982 + Glyoxalase I + Protein of unknown function DUF4125 + Domain of unknown function DUF861, cupin-3 + GYF-like domain + Precorrin-3B C17-methyltransferase domain + Two-component sensor kinase, N-terminal + ERCC3/RAD25/XPB helicase, C-terminal domain + Ribosomal protein L19/L19e + Domain of unknown function DUF1611_N, Rossmann-like domain + Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site + Conserved hypothetical protein CHP02300, FYDLN acid + Head decoration protein D + Protein of unknown function DUF3833 + Menbrane protein HflK, N-terminal + Domain of unknown function DUF4037 + RNA polymerase recycling, bacterial, C-terminal + Peptidase M20B, peptidase T-like + Protein of unknown function DUF99 + Protein of unknown function DUF3391 + Ribosome-associated, YjgA + tRNA intron endonuclease, N-terminal + Multicopper oxidase, copper-binding site + Domain of unknown function DUF1743 + Nicotinate phosphoribosyltransferase pncB-type + Bacterial TonB-dependent receptor + Protein of unknown function DUF1614 + Protein of unknown function DUF3276 + Fructosamine/Ketosamine-3-kinase + GPN-loop GTPase + Phosphotransferase system, mannose/fructose/sorbose family IID component + Phosphotransferase system, mannose/fructose/sorbose family, IIC subunit + Flagellar hook-associated protein 3 + Formylmethanofuran dehydrogenase subunit C + Excalibur calcium-binding domain + Protein of unknown function DUF1294 + Protein of unknown function DUF2478 + Protein of unknown function DUF2484 + Protein of unknown function DUF4276 + Protein of unknown function DUF1674 + Peptidase M61, catalytic domain + tRNA nucleotidyltransferase, substrate binding + Urease nickel binding site + Domain of unknown function DUF4167 + Cytochrome c oxidase, subunit IV, bacterial aa3 type + Domain of unknown function DUF3298 + Protein of unknown function DUF3299 + XPG/Rad2 endonuclease + Aconitase/Iron-responsive element-binding protein 2 + Bacteriophage lambda NinG + Domain of unknown function DUF3495 + Deacetylase PdaC + Domain of unknown function DUF1588 + Glycosyltransferase 61 + Tetrahaem cytochrome domain + Spermidine/spermine synthases + Heptaprenyl diphosphate synthase component I + Flagellar biosynthetic protein FlhB + Phospholipase A1 + Methylene-tetrahydromethanopterin dehydrogenase, N-terminal + AGR-C-984p-like domain + PucR C-terminal helix-turn-helix domain + CRISPR-associated protein Cas7/Cst2/DevR + Uncharacterised conserved protein UCP029693 + Protein of unknown function DUF2148 + Nitrite reductase [NAD(P)H] large subunit, NirB + Restriction endonuclease, type II, CfrBI + Fibrobacter succinogenes major paralogous domain + tRNA-guanine transglycosylase, patch-forming domain C2 + Protein of unknown function DUF1116 + Protein of unknown function DUF3553 + Protein of unknown function DUF2141 + Putative PD-(D/E)XK phosphodiesterase (DUF2161) + Protein of unknown function DUF2852 + Probable protein kinase UbiB + D-glutamate cyclase + N-acetylmuramic acid 6-phosphate etherase MurQ + Transposase, Helix-turn-helix domain + Cytochrome c-type biogenesis protein CcsA + Uncharacterised conserved protein UCP028101 + Redox-sensitive transcriptional activator SoxR + Protein of unknown function DUF3871 + Flavodoxin-like + Phosphatidylserine decarboxylase + Anthrone oxygenase + Ceramide glucosyltransferase + Ribonuclease H2, subunit A + Mutator MutT + Peptidase T1A, proteasome beta-subunit + 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase, type 1 + Regulator of ribonuclease activity A + Protein of unknown function DUF2889 + Putative metal-binding motif + MULE transposase domain + Urease active site + Type IV minor pilin ComP + Domain of unknown function DUF2249 + PhnA protein + DGC + Peptidase A31, hydrogenase maturation protease HycI + Pectic acid lyase + Cobalamin-dependent methionine synthase + Protein of unknown function DUF2334 + Ribosome maturation protein SBDS, C-terminal + Domain of unknown function DUF4174 + Zinc finger, TFIIS-type + Phosphoethanolamine transferase, N-terminal + Restriction endonuclease, type II, HinP1I + Protein of unknown function DUF411 + Protein of unknown function DUF1552 + Serine-threonine/tyrosine-protein kinase, catalytic domain + Sulfur oxidation c-type cytochrome SoxX + AMP nucleoside phosphorylase, N-terminal + Protein of unknown function DUF2800 + Protein of unknown function DUF3775 + Septum formation inhibitor MinC + Ribosomal protein S6e + Penicillin-binding protein 1C + tRNA pseudouridine synthase II, TruB, subfamily 1, C-terminal + Domain of unknown function DUF4158 + Diphthine synthase + Beta-phosphoglucomutase + Protein of unknown function DUF1467 + Phosphodiesterase YfcE, conserved site + Chromate transporter, long chain + Flagellum biosynthesis repressor FlbT + rRNA small subunit methyltransferase B + Coenzyme A transferase active site + Uncharacterised protein family UPF0229 + Mannosyl-3-phosphoglycerate phosphatase, thermophiles + XPG-I domain + AlgX/AlgJ, SGNH hydrolase-like domain + Domain of unknown function DUF1605 + Receptor L-domain + Integral membrane protein EMC3/TMCO1-like + Peptidase M2, peptidyl-dipeptidase A + Sensor N-terminal transmembrane domain + SoxAX cytochrome complex subunit A + Uncharacterised conserved protein UCP020408 + Signal transduction histidine kinase, HWE region + Domain of unknown function DUF3854 + Glutamyl-tRNA(Gln) amidotransferase subunit E + Peptidyl-tRNA hydrolase, PTH2 + Domain of unknown function DUF1722 + Proliferating cell nuclear antigen, PCNA + Flagellin, archaea + Domain of unknown function DUF2059 + Putative endonuclease, Z1 domain + Protein of unknown function DUF2080, transposon-encoded + Uncharacterised protein family UPF0201 + Holliday junction resolvase Hjc + O-phosphoseryl-tRNA(Cys) ligase + Peptide Chain Release Factor eRF1/aRF1, N-terminal + 5-nucleotidase + Glycoside hydrolase 35, catalytic domain + ST7 + Domain of unknown function DUF1957 + Elongation factor P--(R)-beta-lysine ligase + Tetrapyrrole biosynthesis, 5-aminolevulinic acid synthase + Proline iminopeptidase + Ryanodine receptor Ryr + Cardiolipin synthase + Ribosomal protein L31e + Ribosomal protein L32e + RNA ligase domain, REL/Rln2 + Peptidase M13, C-terminal domain + TfoX, C-terminal + DNA repair protein MmcB-like + Glycosyl hydrolase family 26 domain + Flavodoxin, long chain + Succinate dehydrogenase cytochrome b558 subunit + Cadherin + Phage tail tube protein, GTA-gp10 + Cellulase, Ig-like domain + Deoxyribodipyrimidine photolyase-related protein + Phenylacetic acid degradation B + Protein of unknown function DUF599 + Domain of unknown function DUF3369 + Protein of unknown function DUF3667 + Ribosomal protein S3Ae + Sodium:galactoside symporter + H-type lectin domain + Putative phage terminase, small subunit, P27 family + Protein of unknown function DUF116 + tRNA intron endonuclease, catalytic domain-like + DUF1653-like domain + Carbohydrate binding module family 6 + Branched-chain amino acid transport system II carrier protein + Protein of unknown function, Gp85/88 + Molybdate ABC transporter, ATP-binding protein + ImcF-related, N-terminal domain + Lysozyme inhibitor LprI, N-terminal + UDP-glucose 4-epimerase CapD, C-terminal domain + Uncharacterised protein family UPF0147 + Siphovirus Gp37-like protein + Flagellar basal-body rod FlgF + Protein of unknown function DUF373 + Anaerobic cobalt chelatase + Flagellar assembly protein A + Formylmethanofuran dehydrogenase, subunit B + Thermosome, archaeal + Protein of unknown function DUF2842 + Clostridium phage phiCTP1, Gp74 + Type VI secretion, TssG-like + Opacity-associated protein A + Domain of unknown function DUF1737 + Bacteriophage terminase, large subunit + Cysteine peptidase, asparagine active site + Haemolysin activator HlyB, C-terminal + Haemerythrin, iron-binding site + DmpG-like communication + GDSL lipase/esterase + Glycine zipper 2TM domain + Restriction endonuclease, type II, Tsp45I + Putative amidase domain + Amino acid adenylation domain + Glutamate synthase, NADH/NADPH, small subunit 2 + Lipase, GDXG, putative serine active site + Lytic transglycosylase, superhelical linker + ATP:guanido phosphotransferase active site + Beta-galactosidase C-terminal + Formylmethanofuran dehydrogenase, subunit A + Molybdenum cofactor guanylyltransferase + Putative selenium metabolism protein, YedE family + S1/P1 nuclease + Octaheme c-type cytochrome + Ribonuclease T2, His active site 1 + Domain of unknown function DUF3817, transmembrane + BRO N-terminal domain + Glycosyltransferase family 1, N-terminal + GTP-binding protein, orthogonal bundle domain + RnfH protein + Type II secretion system protein C, N-terminal + Vibrio phage ICP1, Orf50 + Glycoside hydrolase, family 24 + Isopentenyl-diphosphate delta-isomerase, type 1 + Protein of unknown function DUF3109 + MCM OB domain + Domain of unknown function DUF3696, C-terminal + Histone-like protein H-NS, C-terminal domain + Nascent polypeptide-associated complex NAC domain + NAD(P)H-quinone oxidoreductase subunit D/H + Protein of unknown function DUF2149 + Flagellar assembly factor FliW domain + Bacterial phosphonate metabolism, PhnH + Bacterial TniB + SPOC-like, C-terminal domain + Cell division protein ZapB + Protein of unknown function DUF1636 + Copper resistance protein D + Type VI secretion system, RhsGE-associated Vgr protein + Aromatic amino acid hydroxylase, C-terminal + Blood group Rhesus C/E/D polypeptide + Abhydrolase domain containing 18 + Phosphoserine aminotransferase, Methanosarcina-type + Acid phosphatase, class B-like + Ribosomal protein L19/L19e, domain 1 + Ribosomal protein L19/L19e, domain 3 + EcsC protein + Signal-peptide peptidase, presenilin aspartyl protease + tRNA (mo5U34)-methyltransferase-like + Flavoprotein WrbA-like + Succinate dehydrogenase, flavoprotein subunit + Protein of unknown function DUF359 + Ribosomal protein S4/S9, eukaryotic/archaeal + SLC26A/SulP transporter + DNA topoisomerase I, catalytic core, alpha/beta subdomain + Protein of unknown function DUF1150 + Domain of unknown function DUF357 + Domain of unknown function DUF4301 + Maltose/Cyclodextrin ABC transporter, substrate-binding protein + 4-oxalocrotonate tautomerase, Pseudomonas-type + Protein of unknown function DUF4932 + Ribonuclease HIII + CRISPR-associated protein, Csm2 Type III-A + Ribosome maturation protein SBDS, N-terminal + ABC transporter, urea, ATP-binding protein, UrtD + Phosphotransferase KptA/Tpt1 + Glycosyl transferase, family 11 + Lipoprotein LPP20-like + CUB domain + Flagellar assembly protein T, C-terminal + Alpha-amylase/4-alpha-glucanotransferase, central domain + Enhanced intracellular survival protein domain + Rhamnan synthesis F + SUF system FeS cluster assembly associated + Phosphoadenosine phosphosulphate/adenosine 5'-phosphosulphate reductase + Bacterial spore germination, immunoglobulin-like domain + Methyltransferase small, N-terminal + Precorrin-2 C(20)-methyltransferase domain + ATP-dependent helicase HrpB + Preflagellin peptidase, C-terminal + EthD domain + RNA polymerase, subunit H/Rpb5 C-terminal + Peptidase M16, middle/third domain + CagE, TrbE, VirB component of type IV transporter system, central domain + Glycosyl transferase family 10 + NusG, domain 2 + XPG N-terminal + Sarcosine oxidase, alpha subunit + Proteasome beta-type subunit, conserved site + Virulence-protein E, N-terminal + Ectoine synthase + Putative uroporphyrinogen-III C-methyltransferase HemX + Fumarate hydratase, class II + Selenium metabolism protein YedF + Gliding motility-associated protein GldM, N-terminal + Transthyretin, conserved site + Cob(I)alamin adenosyltransferase N-terminal domain + Peptidase S1B + Phosphopantoate/pantothenate synthetase + Uridylate kinase, archaeal/spirochete, putative + Protein of unknown function DUF2867 + Domain of unknown function DUF1987 + Flagellar biosynthesis protein FliR + Protein of unknown function DUF1853 + ATPase, type IV, pilus assembly, PilB + CRISPR-associated protein Cse3 + Sulphur relay, TusC/DsrF + Type II secretion system GspD + Phospholipase A2 domain + Kre9/Knh1 family + Hydrogenase nickel incorporation protein HypA/HybF, conserved site + Pyridoxamine 5-phosphate oxidase, FMN-dependent + Erythronate-4-phosphate dehydrogenase, dimerisation domain + Motility protein FimV, N-terminal + RNase P subunit p30 + Ribosomal protein S4e, central region + Glucodextranase-like, C-terminal + GLPGLI family protein + Ribosomal protein L5 eukaryotic/L18 archaeal + Ribulokinase + ABC transporter, urea permease protein UrtB, bacterial-type + (5-formylfuran-3-yl)methyl phosphate synthase + UDP-N-acetylglucosamine 4,6-dehydratase (inverting) + Putative beta-barrel porin-2, OmpL-like. bbp2 + Transcriptional repressor BetI + CRISPR-associated RAMP Csm3 + Glutathione peroxidase conserved site + Type II secretion system (T2SS), protein M subtype b + Peptidase C13, legumain + Protein of unknown function DUF4255 + Carboxylesterase type B, active site + Sarcosine oxidase subunit beta + Haem-binding domain + Ribosomal protein L19/L19e, domain 2 + Mannose-6-phosphate isomerase + Protein of unknown function DUF1217 + Ribosomal protein L26/L24, eukaryotic/archaeal + NADH-quinone oxidoreductase, chain G, C-terminal + Oligopeptide transporter OPT + Conserved hyptotheical protein CHP03862, flavoprotein, PP4765 + Type VI secretion system effector, Hcp + Flagellar assembly factor FliW + Protein of unknown function DUF424 + Plasmid conjugal transfer TrbL/VirB6 + Disulphide bond isomerase, DsbC/G, N-terminal + Methyltransferase MtrA/MtxA + Domain of unknown function DUF4173 + Anaphase-promoting complex subunit 4, WD40 domain + Reverse transcriptase, N-terminal domain + Arginine N-succinyltransferase AstA/AruG + 1,4-alpha-glucan-branching enzyme, GlgB + Curlin associated + Protein of unknown function DUF4282 + Type VI secretion protein, VC_A0114 + Protein transport protein SecG/Sec61-beta/Sbh + DNA topoisomerase I + Protein of unknown function DUF2849 + Acetoacetyl-CoA synthase + Tetrahydrodipicolinate N-succinyltransferase, transferase hexapeptide repeat family + Archaeal Nre, C-terminal + FadR, C-terminal domain + Glycosyltransferase, DXD sugar-binding motif + Alpha amylase + Long-chain-fatty-acyl-CoA reductase, LuxC + Translation initiation factor IF2/IF5 + Gamma/beta/epsilon proteobacterial P-protein, chorismate mutase domain + Methylglyoxal synthase, active site + Flavocytochrome c sulphide dehydrogenase, flavin-binding + Fe(II) trafficking protein YggX + Protein of unknown function DUF2798 + Ribosomal protein L15e core domain + Recombinase NinB + Protein of unknown function DUF560 + Uncharacterised domain, YlbE + NlpB/DapX lipoprotein + 3-hydroxybutyrate dehydrogenase + Protein of unknown function DUF4011 + Conserved hypothetical protein CHP00270 + Putative PD-(D/E)XK family member (DUF4420) + Sulphur oxidation, SoxY + Ribosomal protein L15e + Serine/threonine-protein kinase Bud32 + Bacillithiol biosynthesis deacetylase, BshB1 + Xanthine phosphoribosyltransferase + Orn/Lys/Arg decarboxylase, major domain + Sulphur relay, TusD/DsrE + DnaJ homologue, subfamily C, member 28, conserved domain + Protein of unknown function DUF4170 + JmjC domain + Prefoldin alpha-like + Phosphotransferase system, IIB component, type 1 + tRNA-splicing endonuclease + Homoserine O-succinyltransferase MetA + MASE1 + Uncharacterised GTP-binding protein, C-terminal + Glycoside hydrolase, family 1, beta-glucosidase + Conserved hypothetical protein CHP02653, peptidase S16 non-peptidase homologue + Protein of unknown function DUF1491 + 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase + Transcription regulator YbiH, C-terminal + Delta-1-pyrroline-5-carboxylate dehydrogenase 3 + Poly(R)-hydroxyalkanoic acid synthase, class I + Protein of unknown function DUF1348 + 3-hydroxyisobutyrate dehydrogenase + Glutaredoxin-like + Sensor histidine kinase NatK, C-terminal domain + Extracellular HAF + Gene transfer agent, major tail protein + CGI121/TPRKB + Protein of unknown function DUF898 + RNA methyltransferase domain + Translation initiation factor IF2/IF5, N-terminal + UDPGP family + Globin + Ribosome maturation protein Sdo1/SBDS + Phospholipase C/D + Uncharacterised protein family, inner membrane CreD + Potential Queuosine, Q, salvage protein family + Hydrolyase LeuD/DmdB, bacterial + Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase + Histidine phosphotransferase ChpT, C-terminal + Trans-2-enoyl-CoA reductase catalytic domain, putative + Transthyretin/hydroxyisourate hydrolase + Protein of unknown function DUF5343 + Exosome complex component, N-terminal domain + Glycosyl hydrolase, C-terminal (DUF3459) + KH domain protein, archaea + ABC transporter, urea, ATP-binding protein, UrtE + Superoxide dismutase, Nickel-type + EPS-associated transcriptional regulator, MarR family + Conjugal transfer TrbC/type IV secretion VirB2 + Bacteriophage phiNM3, A0EWY4 + mRNA interferase toxin MqsR + Protein of unknown function DUF3842 + Aldose 1-epimerase, conserved site + Ribosomal protein S17, archaeal/eukaryotic + Lipocalin family conserved site + Protein of unknown function DUF5103 + Poly-beta-hydroxybutyrate polymerase N-terminal + Protein of unknown function DUF4345 + Peptidase M24A, methionine aminopeptidase, subfamily 2 + YcgL domain + Transcription regulator TrmB, C-terminal + Protein of unknown function DUF3570 + Glutathione S-transferases, class Zeta + Nop2p + Protein of unknown function DUF3035 + Integrase SSV1, C-terminal + Ribonucleotide reductase small subunit, acitve site + Virulence factor domain + Protein of unknown function DUF3576 + Translation elongation factor IF5A + Cytoplasmic tRNA 2-thiolation protein 1 + Protein of unknown function DUF4199 + Protein of unknown function DUF445 + SseB protein N-terminal domain + Ribosomal protein L7Ae, prokaryotes + Ribosomal protein L22/L17, eukaryotic/archaeal + Cyclic-AMP phosphodiesterase, class-II + Coenzyme PQQ synthesis D, bacteria + Ribosomal protein S24e + Ku70/Ku80 beta-barrel domain + Peptidase S49, protease IV + Capsid protein, T4-like bacteriophage + Acetate-CoA ligase [ADP-forming], alpha domain + Peptidase C25, Ig-like domain + Major capsid protein Gp5 + HPr(Ser) kinase/phosphorylase + Domain of unknown function DUF5050 + 5-bromo-4-chloroindolyl phosphate hydrolysis protein + Ubiquinone biosynthesis protein COQ9 + Protein of unknown function DUF1045 + Toxin HigB-2 + ATPase terminase subunit, putative + LapD/MoxY, periplasmic domain + Domain of unknown function DUF4209 + Domain of unknown function DUF2357 + Protein of unknown function DUF2058 + Domain of unknown function DUF3772 + Protein of unknown function DUF881 + Selenoprotein, Rdx type + FTP domain + 2-phospho-L-lactate transferase + Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase + Cobalamin (vitamin B12) biosynthesis CobW + Probable transcription termination protein NusA, archaeal + Sulphate anion transporter, conserved site + YARHG domain + Transglutaminase-like domain + Type III secretion system flagellar brake protein YcgR, N-terminal + Domain of unknown function DUF305 + Uncharacterised conserved protein UCP012608 + D-cysteine desulfhydrase + Diphosphomevalonate decarboxylase + Outer membrane lipoprotein LolB + COQ9 + NUMOD4 + Isocitrate dehydrogenase kinasephosphatase + Hypothetical protein TM1410-related + Histone-lysine N-methyltransferase DOT1 domain + Malate synthase G + Peptidase T1A, proteasome beta-subunit, archaeal + AAA-ATPase-like domain + Fructose 1-phosphate kinase + Yjdj-type Gcn5-related N-acetyltransferase + Methylaspartate ammonia-lyase, C-terminal + Peptidase S55, SpoIVB + Ribosomal protein S8e/ribosomal biogenesis NSA2 + Uncharacterised domain UPF0702, alpha/beta domain + Copper ion binding protein + Phage conserved hypothetical protein, C-terminal + Malonyl-CoA decarboxylase, C-terminal + Bifunctional transglycosylase second domain + Protein of unknown function DUF779 + Protein of unknown function DUF3644 + Peptide chain release factor eRF1/aRF1 + Anti-sigma K factor RskA + Protein of unknown function DUF1697 + TrpR homologue YerC/YecD + Ribulose bisphosphate carboxylase, large chain, active site + Transcription regulator HTH, AraC- type, ligand binding domain-like + Type VI secretion system, RhsGE-associated Vgr family subset + Nucleoside-specific channel-forming protein, Tsx-like + Translation initiation factor IF6 + Ribosomal protein S19e + Succinate semialdehyde dehydrogenase + TnsA endonuclease, N-terminal + Flagellar motor stator, MotA + Flagellar FlaF + CRISPR-associated protein Cse2 + Phosphoserine aminotransferase + Translation initiation factor 2, alpha subunit, middle domain + Peptidase M4 domain + D-Lysine 5,6-aminomutase alpha subunit + PAN/Apple domain + NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal + Glycosyltransferase 2-like, prokaryotic type + CRISPR-associated protein Csm1 + HopJ type III effector protein + Fumarylacetoacetase + NADH ubiquinone oxidoreductase, F subunit + SaV-like + Translation elongation factor, IF5A, hypusine site + Protein of unknown function DUF1622 + Ribosomal protein L21e + BLUF domain + Coproporphyrinogen III oxidase, conserved site + Protein of unknown function DUF4270 + Selenium-dependent molybdenum hydroxylase system protein, YqeB family + Polyhydroxyalkanoate depolymerase + Domain of unknown function DUF5009 + tRNA-dihydrouridine(20/20a) synthase + Gliding motility-associated protein, GldL + Ribosomal protein S8e + Protein of unknown function DUF4387 + Prefoldin alpha subunit, archaea-type + Cas6b, C-terminal domain + Protein of unknown function DUF4835 + Protein of unknown function DUF3352 + DNA sulphur modification protein DndE + AP2-like integrase, N-terminal domain + F0F1-ATPase subunit, putative + Lipocalin, bacterial + N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA + Transcription elongation factor Spt5, archaeal + Protein SirB1, N-terminal + Metal-dependent protein hydrolase + Nitrous oxide reductase family maturation protein NosD + CRISPR-associated protein, TM1807 + Uncharacterised protein family UPF0753 + Cyanate hydratase + Polymerase A arginine-rich C-terminal domain + Cytochrome c-552/DMSO reductase-like, haem-binding domain + Protein of unknown function DUF3131 + SdiA-regulated + Xanthine dehydrogenase, molybdopterin binding subunit + Restriction endonuclease, type II, Bpu10I + Rhamnosyl O-methyltransferase/Cephalosporin hydroxylase + Formate dehydrogenase, gamma subunit + Domain of unknown function DUF4910 + Prefoldin beta-like + Signal recognition particle, SRP19 subunit + Protein of unknown function DUF2783 + TFIIEalpha/SarR/Rpc3 HTH domain + CRISPR-associated protein Cas1, HMARI/TNEAP subtype + Protein of unknown function DUF1328 + Benzoate transporter + Acetaldehyde dehydrogenase, C-terminal + DNA recombination/repair protein RadA + Type IV Pilus-assembly protein W + Protein of unknown function DUF2142, membrane + Signal transduction histidine kinase, 5TM receptor LytS, transmembrane region + Ribosomal protein S4e, N-terminal + GNAT acetyltransferase YdfB-like + Capsule biosynthesis protein CapB + DNA topoisomerase I, DNA binding, eukaryotic-type + Capsule biosynthesis protein CapC + RNA polymerase sigma-70, Bacteroidetes type + Anti-sigma factor ChrR, putative + Thermostable hemolysin + Formylmethanofuran: tetrahydromethanopterin formyltransferase Ftr + Translation initiation factor 2, alpha subunit + Glycosyl transferase, family 8 + Restriction endonuclease, type II, EcoRII, C-terminal + MobA/MobL protein + Spi protease inhibitor + Protein of unknown function DUF2271 + RNA polymerase Rpb7, N-terminal + ROSMUCR transcriptional regulator + HAD-superfamily hydrolase, subfamily IA, YjjG/YfnB + HAD-superfamily hydrolase, subfamily IIA, hypothetical 3 + Repressor KorB domain + UDP-N-acetylglucosamine 2-epimerase,UDP-hydrolysing + Outer membrane lipoprotein carrier protein LolA, Proteobacteria + Protein of unknown function DUF2178, transmembrane + Ribosomal protein S13/S15, N-terminal + Glycosyl hydrolase family 30, beta sandwich domain + RNA polymerase Rpb2, domain 4 + RNA polymerase Rpb2, domain 5 + UV-endonuclease UvdE + Peptidase S49, N-terminal proteobacteria + Glycoside hydrolase, chitinase active site + Peptidase M4, C-terminal + BCCT transporter, conserved site + Protein of unknown function DUF420 + Transcription elongation factor Spt5, NGN domain + Proline dehydrogenase PutA, domain I + Protein of unknown function, OB-fold-containing + Protein of unknown function DUF2750 + Aspartate transcarbamylase regulatory subunit + PuuE allantoinase/chitin deacetylase 1 + Co-chaperone HscB, C-terminal oligomerisation domain + Nuclease SbcCD subunit D, C-terminal domain + Homoserine/serine acetyltransferase MetX-like + Nop domain + Diphthamide synthesis DPH1/DPH2 + dUTPase/dCTP pyrophosphatase + PrcB C-terminal domain + Flotillin, C-terminal domain + Guanine deaminase + Phosphotransferase system, fructose-specific IIB subunit + Phenylacetate-CoA oxygenase, PaaJ subunit + Protein of unknown function DUF4438 + Restriction endonuclease, type II, XcyI + Uncharacterised protein family AroM + Domain of unknown function DUF1338 + Translation initiation factor 2, alpha subunit, C-terminal + Elongation factor Tu-type domain + Filamentous haemagglutinin, N-terminal + RloB-like protein + Peptidoglycan-binding protein, CsiV + Cysteine-rich small domain + Uncharacterised conserved protein UCP025560 + Anaphase-promoting complex subunit 5 + Protein of unknown function DUF1249 + Ribosomal protein S27a + Trans-2-enoyl-CoA reductase + Protein of unknown function DUF3568 + Regulator of ribonuclease activity B domain + Chorismate mutase, bacteria + Protein of unknown function DUF3584 + Uncharacterised protein family UPF0274 + Domain of unknown function DUF4111 + 3'-5' exoribonuclease Rv2179c-like domain + Peptidase C15, pyroglutamyl peptidase I + DNA-directed RNA polymerase, M/15kDa subunit + Blue (type 1) copper domain + Domain of unknown function DUF5011 + GTP-binding protein, ribosome biogenesis + DNA-directed RNA polymerase, phage-type + Malonate decarboxylase/citrate lyase acyl carrier protein + Methyl-coenzyme M reductase, alpha/beta subunit, domain 2, C-terminal + Methylaspartate ammonia-lyase, N-terminal + ImpA, N-terminal + Conserved hypothetical protein CHP02243 + Ribosomal protein L37ae + Restriction endonuclease, type II, AvaI/BsoBI + Invasion gene expression up-regulator, SirB + CRISPR-associated protein, Cas02710 + SET domain + tRNA (pseudouridine(54)-N(1))-methyltransferase, TrmY + Translation initiation factor 2, gamma subunit, C-terminal + Choline sulfatase enzyme C-terminal domain + Nitrate transport ATP-binding subunit C/D + B-box-type zinc finger + Pentatricopeptide repeat + Protein of unknown function DUF1786, putative pyruvate format-lyase activating enzyme + Ribonuclease P/MRP protein subunit + Translocon Sec61/SecY, plug domain + Uncharacterised conserved protein UCP004929, methanogenesis + DNA primase DnaG, DnaB-binding domain + Ribosomal protein L7Ae/L8/Nhp2 family + RsbT co-antagonist protein RsbRD, N-terminal domain + KH domain, archaeal + Arginine repressor + Uncharacterised protein family, Ynq1 + Protein of unknown function DUF3822 + DNA integrity scanning, DisA, linker region + Exostosin-like + Protein of unknown function UCP009160 + Indolepyruvate ferredoxin oxidoreductase, beta subunit + Transposase Tn5, dimerisation + Methylamine utilisation protein, MauE + Glycosyl hydrolase family 63, C-terminal + Domain of unknown function DUF676, lipase-like + Siphovirus-type tail component + MerC mercury resistance protein + Glycosyl hydrolase family 66 + CRISPR-associated protein Csh2 + Protein of unknown function DUF3578 + PrlF antitoxin + Glycoside hydrolase, family 4, conserved site + Protein of unknown function DUF3810 + YbgF, trimerisation domain + RNA polymerase II, Rpb4 + Ribonuclease, PIN domain + Glucan biosynthesis, periplasmic, MdoG C-terminal + Ethanolamine ammonia lyase large subunit + Squalene/phytoene synthase, conserved site + Extradiol ring-cleavage dioxygenase, class I /II + tRNA 2-selenouridine synthase + Phosphotransferase system EIIB, cysteine phosphorylation site + Maltose/galactoside acetyltransferase + Transcription elongation factor GreB + Bestrophin/UPF0187 + tRNA ribose 2'-O-methyltransferase, aTrm56 + Ribosomal protein S5, eukaryotic/archaeal + DNA-directed RNA polymerase, RBP11-like dimerisation domain + 4-hydroxybenzoate polyprenyltransferase-related + Protein DJ-1 + Lipase, GDSL, active site + Thioesterase, putative + Ribosomal protein L6P, archaea + DNA N-6-adenine-methyltransferase + Protein of unknown function DUF3047 + Ribonuclease H1, N-terminal + Tryptophanase, conserved site + Protein of unknown function DUF421 + Recombination endonuclease VII + SdpI/YhfL protein family + Domain of unknown function DUF1585 + Actin family + 1,2-phenylacetyl-CoA epoxidase, subunit C + CTAG/Pcc1 family + Chalcone isomerase, 3-layer sandwich + YHYH domain + DNA-directed RNA polymerase, subunit E/RPC8 + N(4)-bis(aminopropyl)spermidine synthase, C-terminal + Mercuric transport protein periplasmic component/copper chaperone CopZ + Protein of unknown function DUF3427 + Protein of unknown function DUF2799 + Poly-gamma-glutamate system protein + Polynucleotide kinase 3 phosphatase + Arginine repressor, C-terminal + (Na+)-NQR maturation factor NqrM + Lipid A biosynthesis, N-terminal + Methyl-coenzyme M reductase, alpha subunit, N-terminal subdomain 2 + tRNA wybutosine-synthesis + Smg + Domain of unknown function DUF3492 + DNA topoisomerase I, domain 1 + SusD-like + Putative threonine/serine exporter + Nitrate reductase chaperone, NarJ + Na+/H+ antiporter NhaB + Elongation factor P hydroxylase + Mitochondrial fission protein ELM1-like + RNA-binding protein YhbY + Domain of unknown function DUF4055 + Uncharacterised protein family, phage tail-like + Ribosome biogenesis protein, C-terminal + Ribosomal protein S17e + Isocitrate dehydrogenase NADP-dependent, dimeric, prokaryotic + Outer membrane lipoprotein Slp + DNA-3-methyladenine glycosylase AlkA, N-terminal + Transposase (putative), YhgA-like + Uncharacterised conserved protein UCP029215 + Translation initiation factor 1A (eIF-1A) + L-fucokinase + Cytidine/deoxycytidylate deaminase, zinc-binding domain + CRISPR-associated protein Cas2 subtype + CRISPR pre-crRNA endoribonuclease Cas5d + Competence-induced protein CoiA-like + Peroxidases heam-ligand binding site + ATP-dependent RNA helicase Ski2, C-terminal + GspL periplasmic domain + SapC + Glutamyl-tRNA(Gln) amidotransferase subunit D + UDP-2,3-diacylglucosamine hydrolase + Urea ABC transporter, substrate-binding protein UrtA-like + ABC transporter, ATP-binding/permease protein + Protein of unknown function DUF1189 + Ribosomal protein S28e + Tol-Pal system, TolA + NAD(P) transhydrogenase, alpha subunit + Ribosomal protein S23, eukaryotic/archaeal + Domain of unknown function DUF4214 + Protein of unknown function DUF4390 + Addiction module killer protein, predicted + O-succinylhomoserine sulfhydrylase + DNA polymerase III subunit delta, C-terminal + FlgD Tudor-like domain + Domain of unknown function DUF927 + Dyskerin-like + Proteinase inhibitor I78 + Hydrogenase/Urease accessory protein HupE/UreJ protein + Phosphonate metabolism PhnG + Prolyl-tRNA editing protein, YbaK/EbsC + Protein of unknown function DUF2877 + Ribosomal protein L13, eukaryotic/archaeal + Glycosyl hydrolase family 30, TIM-barrel domain + N-ATPase, AtpR subunit-like + Type II secretion system protein M, periplasmic domain + Multicopper oxidases, conserved site + Ralstonia phage RSL1, Orf186 + Cyanate lyase, C-terminal + Translin family + Thiaminase II + Ribosomal protein S19A/S15e + L-threonine-O-3-phosphate decarboxylase + L-arabinose isomerase, C-terminal + Helical and beta-bridge domain + Uncharacterised protein family UPF0270 + Peptidase U32, collagenase + Protein of unknown function DUF2959 + Translation release factor pelota + Protein of unknown function DUF2326 + Sulphotransferase Stf0, domain + Phosphoesterase + Nitrate reductase, gamma subunit + Carbohydrate binding module family 11 + Cytidylate kinase, putative + Type I secretion C-terminal target domain, VC_A0849 subclass + Protein of unknown function DUF63 + Phage tail assembly chaperone protein, TAC6 + Conserved hypothetical protein CHP02687 + Thymidine phosphorylase/AMP phosphorylase + Anti sigma-E protein RseA, N-terminal + Transcription factor S + Domain of unknown function DUF3641 + ImcF-related + Cyclo-malto-dextrinase, C-terminal + Signal transduction response regulator, propionate catabolism activator, N-terminal + NADAR + Phenylalanyl-tRNA synthetase, class IIc, beta subunit, archae/euk cytosolic + Protein of unknown function DUF2066 + Protein of unknown function DUF2069, membrane + TRAP transporter T-component + Protein of unknown function DUF4154 + Putative Actinobacterial Holin-X, holin superfamily III + Decarboxylase MfnA, archaea + Histidinol-phosphatase + Protein of unknown function DUF2950 + L-threonine dehydratase biosynthetic IlvA + Putative metallopeptidase + Protein of unknown function DUF4271 + Proto-chlorophyllide/chlorophyllide reductase, C-terminal + Uncharacterised protein family UPF0283 + Protein of unknown function DUF1415 + 2-methylcitrate synthase/citrate synthase type I + AMP nucleosidase + Ribosomal protein L12, archaea + Protein of unknown function DUF2795 + SOUL haem-binding protein + Endosomal/lysomomal potassium channel TMEM175 + Carbohydrate kinase, thermoresistant glucokinase + Glutamate synthase, NADH/NADPH, small subunit 1 + CRISPR-associated protein Cas1, ECOLI subtype + Gliding motility-associated lipoprotein, GldH + Alpha/beta hydrolase fold-5 + ArsR-type transcription regulator, HTH motif + Protein of unknown function DUF1269, membrane associated + Glycyl radical enzyme, PFL2/glycerol dehydratase family + Chorismate--pyruvate lyase + Phosphoenolpyruvate carboxylase, His active site + Copper binding periplasmic protein CusF + RecBCD enzyme subunit RecD + Protein of unknown function DUF371 + 2,4-diaminobutyrate 4-transaminase + Protein of unknown function DUF434 + Domain of unknown function DUF2489 + Protein of unknown function DUF2306, membrane + Hydroxymethylglutaryl-coenzyme A synthase, N-terminal + Cytochrome c552 + Type VII secretion system ESAT-6-like + Cytochrome c, class III + Nucleotidyltransferase, predicted + Flap structure-specific endonuclease, archaea + Protein of unknown function DUF3010 + Enoyl reductase FAD binding domain + Phosphotransferase system, fructose IIC component + Ammonia monooxygenase/particulate methane monooxygenase, subunit C + Exopolysaccharide synthesis, ExoD + SusE outer membrane protein + Acetaldehyde dehydrogenase + Protein of unknown function DUF2092, periplasmic + Fructose-bisphosphate aldolase, class II, yeast/E. coli subtype + Fructose-bisphosphate aldolase, class II, Calvin cycle subtype + Nicotinamide-nucleotide adenylyltransferase, archaeal type + GspL, cytoplasmic actin-ATPase-like domain + CHASE4 + Protein of unknown function DUF2784 + Mth639-like domain + Ribosomal protein L44e + Protein of unknown function DUF2160, transmembrane + Putative 8-amino-7-oxononanoate synthase, Archaea/Firmicutes type + ADP-L-glycero-D-manno-heptose-6-epimerase + Histidine kinase BarA, N-terminal + Protein of unknown function DUF4290 + Double-strand break repair protein AddB + Putative sodium bile acid cotransporter + Protein of unknown function DUF3536 + Protein of unknown function DUF2796 + Uncharacterised protein family 14.7kDa + Phenylacetic acid degradation protein PaaD + ABC transporter, urea, permease protein, UrtC + Protein of unknown function DUF4019 + AraC-type transcription regulator, ligand-binding domain + Protein of unknown function DUF935 + Isocitrate dehydrogenase NADP-dependent + Inner membrane protein YebE + Protein of unknown function DUF4254 + Arginine repressor, DNA-binding domain + MucB/RseB, N-terminal + Pseudaminic acid biosynthesis, PseI + Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ + 2-hydroxy-3-oxopropionate reductase + Conserved hypothetical protein CHP02058 + Gliding motility associated protein GldN + GlyGly-CTERM domain + Protein of unknown function DUF1805 + Transcriptional regulator AbiEi antitoxin, N-terminal domain + Putative selenium-dependent hydroxylase accessory protein YqeC + DNA topoisomerase I, zinc ribbon-like, bacterial-type + Protein of unknown function DUF3445 + Thiosulfohydrolase SoxB + S-layer protein, C-terminal + Protein of unknown function DUF2878 + Inositol 2-dehydrogenase + Ribosomal protein S6e, conserved site + Serine proteases, trypsin family, serine active site + Mycobacteriophage D29, Gp61 + Uncharacterised protein family HI1736/YgjV + Selenoprotein B, glycine/betaine/sarcosine/D-proline reductase family + DNA polymerase beta, palm domain + GHMP kinase group 1 + Putative glutamate--cysteine ligase YbdK + Ribosomal protein L7Ae, archaea + High mobility group box domain + PhnB-like + Protein of unknown function DUF2891 + Coenzyme PQQ biosynthesis protein C + Gliding motility-associated protein GldM, C-terminal + Protein of unknown function DUF1699 + CRISPR-associated protein, CasD + Peptidase U9, T4 prohead protease + Protein of unknown function DUF4407 + Signal transduction histidine kinase, P2 response regulator-binding + Protein of unknown function DUF1576 + Ribosomal protein L30, central domain, archaeal type + Aminodeoxychorismate lyase, class IV + Cyclomaltodextrinase, N-terminal + Isochorismatase + Ribosomal protein L3-specific, glutamine-N5-methyltransferase + Threonine/Serine exporter, ThrE + Receptor, ligand binding region + ATP phosphoribosyltransferase regulatory subunit + Prefoldin subunit beta + Vitamin K-dependent gamma-carboxylase + Carboxy-S-adenosyl-L-methionine synthase + Fungal lipase-like domain + RNA helicase HrpA + CRISPR-associated protein, Cmr3 + Divergent 4Fe-4S mono-cluster + Nitrate reductase, alpha subunit, N-terminal + RNA polymerase sigma-70 RpoE type + Addiction module antidote protein, HI1420 + Cellulose synthase operon protein BcsQ + Oxygen-dependent choline dehydrogenase + Neurotransmitter-gated ion-channel ligand-binding domain + Arc-like DNA binding domain + 6-phosphogluconate dehydratase + Domain of unknown function DUF2157 + Protein translocase SEC61 complex, gamma subunit + Domain of unknown function DUF3412 + Phage replisome organiser, N-terminal domain + Protein of unknown function DUF4153 + Malonyl-CoA decarboxylase, N-terminal + Tubulin-like + Protein O-mannosyl-transferase, C-terminal four TM domain + Ribosomal protein S3, eukaryotic/archaeal + Archaeal/bacterial translation initiation factor SUI1 + Thiamine transporter ThiT + Protein of unknown function DUF1282 + Cysteine synthase CysM + Protein of unknown function DUF3429 + Domain of unknown function DUF4296 + RNHCP domain + Putative zinc ribbon domain + Na+/H+ antiporter NhaC + Restriction endonuclease, type II, EcoRI/MunI + Replication initiation factor + Replication protein C + Protein of unknown function DUF4169 + Malate dehydrogenase, active site + Zeta toxin domain + Protein of unknown function DUF1572 + Protein of unknown function DUF2158 + Mechanosensitive ion channel inner membrane domain 1 + tRNA wybutosine-synthesizing protein + Glycosyl hydrolases related to GH101 family, GHL1-GHL3 + Aminotransferase, putative + Conserved hypothetical protein CHP03790 + Ricin B, lectin domain + Conjugal transfer, TrbG/VirB9/CagX + Phosphofructokinase, mixed-substrate PFK group III + Protein of unknown function DUF3617 + Diol/glycerol dehydratase, large subunit + D-aminoacyl-tRNA deacylase DtdA + Glycerophosphoryl diester phosphodiesterase, membrane domain + Beta propeller phytase + Flagellar regulatory FleQ + MiaB-like tRNA modifying enzyme, archaeal-type + DNA polymerase III, tau subunit, domain V + Acyl-CoA desaturase + Protein of unknown function DUF3341 + Protein of unknown function DUF3014 + Poly(A) polymerase I + Glycoside hydrolase family 27/36, conserved site + Putative bacilliredoxin, YphP/YqiW family + Domain of unknown function DUF4376 + Phage holin, LL-H family + Uncharacterised protein MJ0570, ATP-binding + Zinc finger, DPH-type + MucB/RseB, C-terminal + TTHA0068-like domain + Glycosyl hydrolases family 31, active site + Flagellar biosynthesis protein FlhF + Protein of unknown function DUF507 + Transposase, Synechocystis PCC 6803 + Ribosomal protein L23 + N-acetyl sugar amidotransferase + Ribonuclease Zc3h12a-like, NYN domain + Ubiquitin-conjugating enzyme E2 + Lipoprotein NlpA family + Topoisomerase I C-terminal domain + Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system + Methylene-5,6,7,8-tetrahydromethanopterin dehydrogenase + Ribosomal protein S5/S7, eukaryotic/archaeal + Protein of unknown function DUF1826 + Porin, LamB type + Uncharacterised protein family, calcium binding protein, CcbP + DNA/RNA non-specific endonuclease, active site + Cobalt transporter subunit CbtA, putative + Dyp-type peroxidase + Hydroxymethylglutaryl-CoA reductase, N-terminal + L-aspartate dehydrogenase, archaeal + 4-hydroxy-2-oxovalerate aldolase + Conserved hypothetical protein CHP03214, putative allantoin-urate catabolism protein + Domain of unknown function DUF4478 + Protein of unknown function DUF268, Caenorhabditis species + PD-(D/E)XK nuclease superfamily 9 + Pilus biogenesis/stability type IV, PilW + Protein of unknown function DUF616 + L-2,4-diaminobutyric acid acetyltransferase + Protein of unknown function DUF1304 + Oleate hydratase + Restriction endonuclease, type II, AccI + Alkyl sulfatase, C-terminal + 1,2-phenylacetyl-CoA epoxidase, subunit A + 8-amino-7-oxononanoate synthase, Archaea/Proteobacteria type + Protein of unknown function DUF3098 + Protein of unknown function DUF3090 + DNA helicase, AddA type + Protein of unknown function DUF1460 + Orn/Lys/Arg decarboxylase, C-terminal + Phosphomannose isomerase, type I, conserved site + UPF0255 family + Potassium channel, voltage-dependent, beta subunit, KCNAB-related + Protein of unknown function DUF2480 + CRISPR-associated protein Cas5, HALMA + Putative aminohydrolase SsnA + NADH:ubiquinone oxidoreductase, subunit G + Type IV / VI secretion system, DotU + AbrB duplication + Protein of unknown function DUF3329 + Glutamate--cysteine ligase, plant-type + Nascent polypeptide-associated complex (NAC), archaeal + Restriction endonuclease, type II, XhoI + Putative PepSY TM-like protein + Impact family, bacterial/archaeal + Aspartate-semialdehyde dehydrogenase, gamma-type + Pathogenicity locus + Ribosomal protein L30, archaeal + Stealth protein CR2, conserved region 2 + Phosphonate metabolim protein, transferase hexapeptide repeat family + ISC system FeS cluster assembly, IscX + tRNA-guanine(15) transglycosylase + NMD3 + DNA polymerase family X + Cache 3/Cache 2 fusion domain + Protein of unknown function DUF790, endonuclease-like + Free Met sulfoxide reductase conserved site + Ribosomal protein S2, eukaryotic/archaeal + Peptidase M43, pregnancy-associated plasma-A + Thiazole biosynthesis domain + Protein of unknown function DUF2240 + Transposase, IS4, N-terminal + Aryldialkylphosphatase, zinc-binding site + Protein of unknown function DUF5372 + Translation initiation factor 2, beta subunit + Protein of unknown function DUF2847 + Glycogen debranching enzyme, GlgX type + Peptidoglycan hydrolase FlgJ + SLA1 homology domain 1, SHD1 + DNA-binding protein Fis + Protein of unknown function DUF1706 + Iron hydrogenase, subset + Xanthine dehydrogenase, small subunit + T1SS-143 repeat-containing domain + Methyltransferase, putative + Domain of unknown function DUF1724 + SEFIR domain + Translation initiation factor 1A (eIF-1A), conserved site + Ribosomal protein S27e + Transaldolase type 2 + 5-carboxymethyl-2-hydroxymuconate isomerase + FAD-binding 9, siderophore-interacting + Dam-replacing + Protein of unknown function DUF3830 + Ribose 1,5-bisphosphate phosphokinase PhnN + Putative N-acetylmannosamine-6-phosphate epimerase + Motility protein FimV, C-terminal + Conserved hypothetical protein CHP03643 + JAB1/MPN/MOV34 metalloenzyme domain + 5,6-dimethylbenzimidazole synthase BluB + Type II secretion system protein I domain + Glutaredoxin-like protein, YruB + Uncharacterised conserved protein UCP037409, membrane transporter, MTH672 + Protein of unknown function DUF4294 + PD-(D/E)XK nuclease superfamily 7 + Acyl-CoA dehydrogenase, C-terminal + Glutamyl-tRNA synthetase, archaeal/eukaryotic cytosolic + Protein of unknown function DUF2937 + Putative amidoligase enzyme + Malate:quinone-oxidoreductase + Protein of unknown function DUF1963 + Bacteriophage 933W, L0084 + Metallophosphoesterase, DNA ligase-associated + Periplasmic sensor domain CHASE8 + Protein of unknown function DUF3305 + Oxaloacetate decarboxylase, alpha subunit + Acetoacetate decarboxylase + Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 + Protein of unknown function DUF4295 + Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain + Crotonyl-CoA reductase + Uncharacterised protein family CreA + Cu(I)-responsive transcriptional regulator + Uncharacterised protein family UPF0319 + Gene transfer agent, rcc01693 + Uncharacterised protein family UPF0348 + Putative ABC-transporter type IV CmpB/TMEM229 + DNA topoisomerase I, archeal-type + Structural protein of head Gp20 + Putative hydrolase RBBP9/YdeN + Bis(5'-nucleosyl)-tetraphosphatase (symmetrical) + Nicotianamine synthase + Protein of unknown function DUF4058 + Carotene biosynthesis associated membrane protein + Exosome complex component Rrp41 + Ribosomal protein S27e, zinc-binding domain + Development/cell death domain + Peptidase M4 + Outer membrane protein Omp28 + Protein of unknown function DUF2970 + Arginine deiminase + Helicase domain + tRNA nucleotidyltransferase, archaea + Domain of unknown function DUF4426 + DNA polymerase II large subunit DP2 + Domain of unknown function DUF2383 + Nicotinate phosphoribosyltransferase + Knr4/Smi1-like domain + Oligosaccharyl transferase, archaeal + Chalcone isomerase + Protein of unknown function DUF3530 + Protein of unknown function DUF624 + Heme biosynthesis-associated TPR protein + Alternate ATP synthase, F1 complex, subunit epsilon + FERM/acyl-CoA-binding protein, 3-helical bundle + Protein of unknown function DUF1177 + Protein of unknown function DUF1326 + Translation elongation factor EF1A, eukaryotic/archaeal + PT repeat + Protein of unknown function DUF2788 + Putative L,D-transpeptidase catalytic domain + Pyruvate carboxylase + Delta-1-pyrroline-5-carboxylate dehydrogenase + Protoporphyrinogen oxidase + DNA-directed RNA polymerase, 14-18kDa subunit, conserved site + CRISPR-associated exonuclease Csa1 + Protein of unknown function DUF2177, membrane + Protein of unknown function DUF4251 + Putative bacterial antitoxin YdaS + Protein of unknown function DUF309 + Domain of unknown function DUF5118 + Type II secretion system protein I + Autoinducer synthesis, conserved site + DNA topoisomerase I, DNA binding, mixed alpha/beta motif, eukaryotic-type + Protein of unknown function DUF1043 + tRNA pseudouridine synthase B family + Glycoside hydrolase family 17 + Ribosomal protein S10, eukaryotic/archaeal + Histone H5 + Sulfite dehydrogenase SoxC + Lysine biosynthesis protein LysW + Ribosome modulation factor + CopC domain + TamA, POTRA domain 1 + Protein of unknown function DUF2953 + Squalene cyclase, N-terminal + Spt4/RpoE2 zinc finger + Protein of unknown function DUF2975 + Lysophospholipase patatin, conserved site + Glycogen/starch/alpha-glucan phosphorylase + Protein of unknown function DUF1376 + Succinylarginine dihydrolase + 4-hydroxybenzoate decarboxylase subunit C + Haem peroxidase, animal type + Alpha,alpha-trehalose-phosphate synthase + Peptidase M64, IgA + General secretion pathway protein F + Polypeptide-transport-associated, ShlB-type + KH-domain/beta-lactamase-domain protein, archaea + Glycosyl hydrolase family 53 + Alpha-macroglobulin, receptor-binding + Uric acid permease UacT-like + Restriction endonuclease, type II, Alw26I/Eco31I/Esp3I + YqcC-like domain + 5-keto-4-deoxyuronate isomerase, N-terminal domain + YP001051499.1-like domain + Signal transduction response regulator, nitrogen regulation NR(I) + PEP-CTERM locus, polysaccharide deactylase + Putative zincin peptidase + Energy-coupling factor transporter ATP-binding protein EcfA1 + Phosphonate C-P lyase system, transcriptional regulator PhnF + Type VI secretion system, lysozyme-related protein + Protein of unknown function DUF4321 + Proteasome alpha subunit, archaeal + Conserved hypothetical protein CHP00488 + Signal transduction histidine kinase + Conserved hypothetical protein CHP01210 + Protein of unknown function DUF4293 + D,D-heptose 1,7-bisphosphate phosphatase + Domain of unknown function DUF2087 + Protein of unknown function DUF2806 + Protein of unknown function DUF4194 + Sporulation regulator WhiA, C-terminal + Protein of unknown function DUF1349 + S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, archaea + Domain of unknown function DUF4130 + C-type lectin-like + Acetyl-CoA decarbonylase/synthase complex subunit alpha + Thiamin/thiamin pyrophosphate ABC transporter, substrate-binding protein, Proteobacteria + DNA-directed RNA polymerase, subunit N/Rpb10 + Putative conjugal transfer protein TraF-related + Tetrahydromethanopterin S-methyltransferase, F subunit + Late competence development protein ComFB + Bacteriophage Mx8, p63, C-terminal + Protein of unknown function DUF4911 + Diphthamide synthesis Dph2, archaea + Amphi-Trp domain + Domain of unknown function DUF4367 + MCM N-terminal domain + AB hydrolase 4, conserved site + Zinc-ribbon 15 + Murein peptide ligase + 2-oxo-acid dehydrogenase E1 component homodimeric type + Bacilysin exporter BacE, putative + Uncharacterised conserved protein UCP033535, periplasmic lipoprotein + Enterobactin synthetase-like, component D + Flagellar assembly protein T, N-terminal + Glycosyl hydrolase family 36, N-terminal + Band 7, C-terminal extension + Succinate dehydrogenase/fumarate reductase flavoprotein subunit, low-GC Gram-positive bacteria + tRNA N6-adenosine threonylcarbamoyltransferase Kae1, archaea + Protein of unknown function DUF1835 + MAM domain + Domain of unknown function DUF1595 + Sulphite reductase, dissimilatory-type alpha subunit + Potassium transporter + Ribosomal protein L32e, conserved site + Pyroglutamyl peptidase I, Cys active site + Hemin uptake protein HemP + Adenylate dimethylallyltransferase + Transcription elongation factor 1 + NADPH-dependent F420 reductase + Co-chaperone Hsc20 + Peroxiredoxin OsmC + ChaB + Inosine monophosphate cyclohydrolase-like + Protein of unknown function DUF3466 + DnaA regulatory inactivator Hda + Protein of unknown function DUF1512 + Signal transduction histidine kinase, phosphate regulon sensor PhoR + DNA-directed RNA polymerase subunit A'' + DNA-directed RNA polymerase subunit A' (Rpo1N) + Siderophore-interacting protein + Carotenoid/retinoid oxidoreductase + Protein of unknown function DUF2116, Zn-ribbon + Sjoegren syndrome/scleroderma autoantigen 1 + F420H(2)-dependent quinone reductase + Protein of unknown function DUF3788 + DNA polymerase alpha/epsilon, subunit B + RIO2 kinase winged helix domain, N-terminal + Sulphate ABC transporter permease protein 2 + tRNA pseudouridine synthase, Pus10 + Haem-binding domain, putative + Peptidase M20/DapE, YgeY + Respiratory nitrate reductase beta, C-terminal + Fatty acid desaturase, type 2 + Replication protein-C C-terminal + Archaeal Type IV pilin, N-terminal + Antirestriction + Protein of unknown function DUF1315 + RecBCD enzyme subunit RecC + Arsenate resistance ArsH + Nitrile hydratase, alpha subunit + Beta-ketoadipyl CoA thiolase + Sporulation regulator WhiA-like + Methyl-coenzyme M reductase, protein C-like + Conserved hypothetical protein CHP03684 + Domain of unknown function DUF1587 + Plasmid replication protein, RepL + Alkaline phosphatase, active site + Adenylyl cyclase class-4/guanylyl cyclase, conserved site + Porin, Gram-negative type + Chloramphenicol acetyltransferase + Domain of unknown function DUF2241 + Protease, Mu phage/prophage I type + Lysine-2,3-aminomutase + Methyl-coenzyme M reductase, alpha subunit, N-terminal + Domain of unknown function DUF1017 + Phosphoglucomutase, alpha-D-glucose specific + 4-aminobutyrate aminotransferase, bacterial + Mannitol repressor MtlR-like + Domain of unknown function DUF3662 + [LysW]-lysine/[LysW]-ornithine hydrolase + tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal + Hydroxymethylglutaryl-coenzyme A synthase C-terminal domain + TerD domain + IPTL-CTERM protein sorting domain + B12-binding domain/radical SAM domain protein, Ta0216 family + Protein of unknown function DUF3549 + Gliding motility-associated protein GldE + Cytochrome c oxidase, subunit I bacterial type + Cellulose synthase BcsB, bacterial + XPG conserved site + Spore germination GerAB + Phosphonate ABC transporter, substrate-binding protein + Glutathione-disulphide reductase + O-acyltransferase WSD1, C-terminal + Restriction endonuclease, type II, Eco29kI + CRISPR-associated protein Cmr2, N-terminal + Ribosomal protein S9, archaeal + NADPH-dependent 7-cyano-7-deazaguanine reductase, QueF type 2 + Protein of unknown function DUF4286 + Protein of unknown function DUF1284 + Pilus modification type IV, PilV + SRA-YDG + DNA replication terminus site-binding protein + Membrane-bound transcription factor site-2 protease + Chlorhexidine efflux transporter + Protein of unknown function DUF3124 + Protein of unknown function DUF1922 + 2-methyl-aconitate isomerase PrpF + 2-aminoethylphosphonate--pyruvate transaminase + ABC transporter, lipid A export, MsbA + Cell division protein ZipA + Protein of unknown function DUF3726 + YcxB-like protein + NIF system FeS cluster assembly, NifU + H/ACA ribonucleoprotein complex, subunit Gar1/Naf1 + Protein of unknown function DUF2884 + Protein of unknown function DUF2789 + Methane/phenol/toluene hydroxylase + Retropepsins + Bacteriophage CI repressor + Peptidase M20A, peptidase V-related + Glucose dehydrogenase, C-terminal + Uncharacterised conserved protein UCP028770 + Translation initiation factor aIF-2, archaea + CRISPR-associated protein Cas7, subtype I-B/Tneap + Encapsulating protein for peroxidase + Glycoside hydrolase family 30 + Protocatechuate 3,4-dioxygenase, alpha subunit + Protein of unknown function DUF3015 + Type-2 restriction enzyme NgoMIV + Folate-biopterin transporter + Outer membrane protein assembly factor BamB + Signal transduction histidine kinase, PEP-CTERM system, putative + Tetrahydromethanopterin S-methyltransferase, subunit D + Type VI secretion system IcmF, C-terminal + Alcohol ABC transporter, permease protein + Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex + Glycoside hydrolase, family 35 + FUN14 + Ribonuclease T2, His active site 2 + Protein of unknown function DUF1887 + Lysine-2,3-aminomutase-like + Protein of unknown function DUF799 + Caudovirus, tape measure, N-terminal + DNA topoisomerase VI, subunit B + DNA topoisomerase III + Replication gene A protein + Diaminopropionate ammonia-lyase + GxGYxYP putative glycoside hydrolase, C-terminal + Protein of unknown function DUF1837 + Tetrahydromethanopterin S-methyltransferase, subunit C + Bacteriophage lambda, Bet + PqqC-like protein + Ribosomal protein L3, archaeal + MHYT domain + Cobalt transporter subunit CbtB, putative + Protein of unknown function DUF3472 + Gas vesicle protein GvpK + Amino-acid N-acetyltransferase + rRNA small subunit methyltransferase F, RNA-binding PUA-like domain + Protein of unknown function DUF2835 + Formate dehydrogenase-N, alpha subunit + CSLREA domain + 3-hydroxyanthranilic acid dioxygenase + Glutamyl-Q tRNA(Asp) synthetase + Protein of unknown function DUF1820 + Protein of unknown function DUF4406 + Intracellular proteinase inhibitor BsuPI + Sulphoacetaldehyde acetyltransferase + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine transaminase + Restriction endonuclease, type II, XamI + 3-oxoadipate enol-lactonase 1/2 + VWFA-related, acidobacterial-type + Alpha carbonic anhydrase + Domain of unknown function DUF551 + C-type lysozyme inhibitor + Trehalose synthase/alpha-amylase, N-terminal + Periplasmic sensor domain + Protein of unknown function DUF2802 + L-fucose isomerase + Platelet-activating factor acetylhydrolase-like + Eukaryotic/archaeal PrmC-related + ELWxxDGT repeat + Type IV secretion system, VirB3 / TrbD / AvhB + Single-strand annealing protein SAK3 + Cadherin-like beta sandwich domain + Threonine dehydratase, catabolic + Protein of unknown function DUF2182, transmembrane, metal-binding + Mannitol dehydrogenase, conserved site + SprA-related family + DNA single-strand annealing protein RecT + Protein of unknown function DUF4112 + Domain of unknown function DUF4266 + Phosphoenolpyruvate carboxylase, Lys active site + Protein of unknown function DUF3187 + Protein of unknown function DUF4861 + Ribosomal protein 50S-L18Ae/60S-L20/60S-L18A + Lipoprotein repeat + Phosphoribosylformylglycinamidine synthase + Ureide permease + Domain of unknown function DUF4114 + Gliding motility-associated lipoprotein, GldD + Molybdenum cofactor biosynthesis protein A, archaea + DEXH box helicase, DNA ligase-associated + Ubiquitin-associated domain + Iron-binding protein IscA, proteobacteria + Protein of unknown function DUF2909 + Conserved hypothetical protein CHP02444 + PQQ-dependent catabolism-associated beta-propeller protein + RNAse P, Rpr2/Rpp21 subunit + Ribosomal protein L24e-related + Myo-inositol-1-phosphate synthase + DNA binding HTH domain, Psq-type + Zinc finger, ZPR1-type + CofG family + Ribosomal protein L10e, conserved site + MEDS domain + CxxxxCH...CXXCH motif, Geobacter sulfurreducens + 1,4-Dihydroxy-2-naphthoyl-CoA synthase, MenB + Peptidase M3B, oligoendopeptidase F + Glutamate--cysteine ligase, monofunctional + Domain of unknown function DUF4346 + Ribosomal protein S13, archaeal + RNA polymerase sigma factor RpoS + Flagellar assembly protein FliH + Domain of unknown function DUF202 + 4-[[4-(2-aminoethyl)phenoxy]-methyl]-2-furanmethanamine-glutamate synthase + ERAP1-like C-terminal domain + dTDP-4-amino-4,6-dideoxygalactose transaminase WecE-like + Protein of unknown function DUF4917 + SatD family + FAD-binding 8 + Nitrile hydratase accessory protein, putative + Domain of unknown function DUF2070, membrane + Thiamine biosynthesis protein ThiF + Arylamine N-acetyltransferase + CHASE3 + Protein of unknown function DUF883, ElaB + Syd + 2-methylisocitrate lyase + HTH DNA binding domain + ECF transporter S component, folate family + CRISPR-associated protein TM1795 + Glyceraldehyde-3-phosphate dehydrogenase, type II + Cleaved adhesin + Stealth protein CR1, conserved region 1 + Protein of unknown function DUF2815 + Mobile mystery protein B + Protein of unknown function DUF1569 + ProQ/FinO domain + Benzoate-CoA ligase family + Restriction endonuclease, type II, HaeII + Protein of unknown function DUF1659 + Translation elongation factor EFG/EF2, archaeal + CRISPR-associated RAMP Cmr4 + 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, middle domain + Head-to-tail joining protein W + Organic hydroperoxide resistance protein famiy + Protein of unknown function DUF227 + Uncharacterised protein family, MJ1172 + Nitrogenase cofactor biosynthesis protein NifB + Inner membrane component domain + Alanine-tRNA ligase, archaea + Translation initiation factor 2, gamma subunit + Protein of unknown function DUF3306 + C1q domain + Protein of unknown function DUF1403 + 7,8-dihydro-8-oxoguanine triphosphatase + Translation elongation factor EF1B, beta chain, archaeal + Protein of unknown function DUF3192 + PTP type protein phosphatase + N-acetylneuraminate synthase + CO dehydrogenase/acetyl-CoA synthase delta subunit + Lon protease, archaeal + Polysaccharide lyase 8, N-terminal alpha-helical + Protein of unknown function DUF1186 + Oligogalacturonate lyase domain + Strictosidine synthase, conserved region + Para-hydroxybenzoic acid efflux pump subunit AaeB/fusaric acid resistance protein + Sublancin immunity protein SunI + Protein of unknown function DUF2780, VcgC/VcgE + Protein of unknown function DUF3360 + Inactive transglutaminase fused to 7 transmembrane helices + Bacterial virulence protein VirB8 + Translation elongation factor, IF5A C-terminal + Histidinol-phosphate phosphatase, putative, inositol monophosphatase + Protein of unknown function DUF3373 + Molybdenum cofactor carrier, putative + TRL-like protein family + Cobaltochelatase subunit CobS + Aspartyl/asparaginy/proline hydroxylase + Adenylylsulphate reductase, beta subunit, C-terminal + CRISPR-associated protein, Cmr5 + tRNA pseudouridine synthase II, TruB, subfamily 2, C-terminal + Vitamin K epoxide reductase + TraG-like, N-terminal + GPI mannosyltransferase 2 + S-ribosylhomocysteinase (LuxS) + Bacterial transcriptional repressor TetR + Uncharacterised domain UPF0547 + Microcin J25-processing protein McjB, C-terminal + DNA-directed RNA polymerase subunit B (Rpo2) + Ectoine biosynthetic protein + Choline-sulfatase + NifC-like ABC-type porter + Ferric iron reductase FhuF domain + Sulphite reductase, dissimilatory-type beta subunit + Ribosomal protein L14P, archaeal + Ribosomal protein L4 + YoaP-like domain + Protein of unknown function DUF1425 + Acyl-CoA-binding protein, ACBP + 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 1-reductase, archaeal + Hom-end-associated Hint + Domain of unknown function DUF3880 + Protein of unknown function DUF817 + 4-hydroxybenzoate 3-monooxygenase + 5-deoxy-glucuronate isomerase, IolB + RNA polymerases, subunit N, zinc binding site + Protein of unknown function DUF2812 + 3-hexulose-6-phosphate isomerase + Glycoside hydrolase, family 32, active site + Activator of aromatic catabolism + Lysine exporter LysO + Domain of unknown function (DUF4878) + Glutathionylspermidine synthase, pre-ATP-grasp-like domain + Protein of unknown function DUF3300 + Protein of unknown function DUF2848 + Muconolactone isomerase domain + Alternate ATP synthase, F0 complex, subunit C, bacterial/archaeal + Zn-ribbon containing protein + Haemolysin-type calcium binding-related + Phenylacetic acid degradation protein PaaN + Hut operon regulatory protein HutP + 26S proteasome regulatory subunit P45-like + Ribonuclease T + B12-dependent dehydratases, beta subunit + Nitrate reductase, beta subunit + Superoxide dismutase, copper/zinc, binding site + tRNA U34 carboxymethyltransferase + Threonine dehydratase, biosynthetic + DNA-binding pseudobarrel domain + T5SS/PEP-CTERM-associated repeat + Phage virion morphogensis protein + Glycerol-3-phosphate responsive antiterminator + Carboxylesterase type B, conserved site + Adenylate cyclase, class-I + Protein of unknown function DUF480 + YnbE-like lipoprotein + Domain of unknown function DUF2786 + Inner membrane protein YejM, N-terminal + 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase + Protein of unknown function DUF669 + Flagellar + Protein of unknown function DUF664 + Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic + Carbohydrate-binding domain-containing protein Cthe_2159 + Conserved hypothetical protein CHP02443 + 8-oxoguanine DNA glycosylase, N-terminal + Ribosomal protein L21e, conserved site + Nitrous-oxide reductase, Sec-dependent + TerB, N-terminal + Predicted virulence protein, SciE type + Helicase HerA, barrel domain + Domain of unknown function DUF2314 + TipAS antibiotic-recognition domain + Protein of unknown function DUF1852 + tRNA (cytidine/uridine-2'-O-)-methyltransferase + Uncharacterised conserved protein UCP004962 + Murein transglycosylase-C, N-terminal + Protein of unknown function DUF2997 + Domain of unknown function DUF1570 + Restriction endonuclease, type II, Pab1 + Type-2 restriction enzyme NaeI + tRNA(Met) cytidine acetyltransferase TmcA, N-terminal + TrwC relaxase + DM13 domain + Protein of unknown function DUF3102 + Protein of unknown function DUF5362 + Type-IV secretion system protein TraC/Conjugative transfer ATPase + Domain of unknown function DUF2220 + Nitrile hydratase, beta subunit + DNA repair and recombination protein RadB + Myxococcus cysteine-rich repeat + Iron permease FTR1/Fip1/EfeU + Domain of unknown function DUF3631 + MoCo/4Fe-4S cofactor protein extended Tat translocation domain + Type VI secretion system, IcmF + Pili assembly chaperone, N-terminal + Flavocytochrome c + Homeodomain, phBC6A51-type + Bulb-type lectin domain + Diol/glycerol dehydratase/dehydratase reactivating factor + Protein of unknown function DUF3080 + Regulator of nucleoside diphosphate kinase, N-terminal domain + Metallophosphoesterase, TT1561-like + Protein of unknown function DUF2082, nucleic-acid-binding, Zn-ribbon + Mor transcription activator + Conserved hypothetical protein CHP02284 + Conserved hypothetical protein CHP02293 + Phage Tail Protein X-like + Insecticide toxin TcdB middle/N-terminal + Oxidoreductase putative, C-terminal + Cobaltochelatase, CobN subunit + DNA binding protein Tfx, C-terminal + Transmembrane Gly-Cys-Arg, conserved site + RNA 3'-terminal phosphate cyclase-like, conserved site + Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site + Peptidase S37, tripeptidyl aminopeptidase + Archaeoflavoprotein AfpA + Phosphotransferase system, sugar-specific permease EIIA type 1 + Bacterial glucose/galactose transporter + Min27-like integrase, DNA-binding domain + Putative cyclic diguanylate phosphodiesterase, CSS motif-containing domain + Type IV conjugative transfer system protein TraH + Domain of unknown function DUF190 + DNA modification/repair radical SAM protein, putative + Alcohol dehydrogenase, zinc-binding type 1 + Copper resistance B precursor + GxGYxYP putative glycoside hydrolase, N-terminal + RecBCD enzyme subunit RecB + Dicarboxylate transport + Signal transduction response regulator, PEP-CTERM system, putative + Uncharacterised protein family NKWYS + Glutamate mutase epsilon subunit + SP1917 domain + Protein of unknown function DUF2986 + Ethanolamine ammonia-lyase light chain + Uncharacterised conserved protein UCP004977 + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose hydrolase + Glycosyl hydrolase family 36, C-terminal + Radical SAM/Cys-rich domain protein + Fructose-1,6-bisphosphate aldolase, class 2 + Domain of unknown function DUF4435 + Protein of unknown function DUF131 + Outer membrane protein SusF/SusE + Uncharacterised conserved protein UCP028291 + DNA metabolism protein, putative + Conserved hypothetical protein CHP00062 + Domain of unknown function DUF2293 + Protein of unknown function DUF2628 + Mechanosensitive ion channel MscS, porin domain + Purine catabolism PurC-like domain + Tetrahydromethanopterin S-methyltransferase, subunit G + Ammonia monooxygenase/particulate methane monooxygenase, subunit B + Protein of unknown function DUF4834 + Alcohol dehydrogenase GroES-associated + Protein of unknown function DUF4625 + Tetrahydromethanopterin S-methyltransferase subunit B + Protein of unknown function DUF2834 + Protein of unknown function DUF4421 + Glycoside hydrolase, family 8 + Coenzyme PQQ biosynthesis protein E, bacteria + Coenzyme PQQ biosynthesis protein B + Bacteriophage A118, Gp4, minor capsid + Protein of unknown function DUF1905 + Kazal domain + Protein of unknown function DUF416 + Nitrate reductase, alpha subunit + tRNA/tmRNA (uracil-C(5))-methyltransferase, TrmA + Poly(R)-hydroxyalkanoic acid synthase, class III, PhaE subunit + Magnesium-chelatase, subunit H + Spermine/spermidine acetyltransferase, N-terminal domain + Glycine/sarcosine/betaine reductase complex, protein B, subunit alpha/ beta + Acyl-CoA dehydrogenase, C-terminal domain + Dihydroxyacetone kinase DhaK, subunit 1 + Conserved hypothetical protein CHP02647 + Protein of unknown function DUF4920 + O-acyltransferase, WSD1, N-terminal + ISC system FeS cluster assembly, IscU scaffold + Profilin conserved site + Peptidase aspartic, AF0612 + Protein of unknown function DUF1495 + HTH-type transcriptional repressor, C-terminal + Bacteriophage Mu, Gp36 + DNA repair protein Rad52/59/22 + Polysaccharide lyase family 8, central domain + CRISPR-associated protein Csc2 + Lipopolysaccharide heptosyltransferase I + Cell division protein ZapD + Thiosulphate/Sulfate-binding protein + CRISPR-associated protein Csh1, C-terminal + Ergothioneine biosynthesis protein EgtB + Putative methanogenesis marker protein 14 + 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal + Restriction endonuclease, type II, SacI + Exosortase D, VPLPA-CTERM-specific + Steroid delta5-4-isomerase + Ferredoxin 2Fe-2S type, proteobacteria + Tetrahydromethanopterin S-methyltransferase, subunit E + Protein of unknown function DUF2164 + Bacteriophage T7, Gp4, DNA primase/helicase, N-terminal + Nitrogenase iron protein NifH + CRISPR-assoc protein, NE0113/Csx13 + Protein of unknown function DUF2955 + Exosortase-related protein XrtF + Glycoside hydrolase, family 76 + Outer membrane insertion C-terminal signal, omp85 target + Calcineurin-like phosphoesterase, C-terminal + D,L-carboxypeptidase, peptidase domain + DNA sulphur modification protein DndD + Fibrogen-binding domain 1 + S-adenosylmethionine decarboxylase, bacterial + Gliding motility-associated lipoprotein, GldB + Gliding motility-associated protein, GldC + CRISPR-associated protein Cas1, NMENI subtype + Lsm, C-terminal + Protein of unknown function DUF4491 + Quinoprotein dehydrogenase-associated SoxYZ-like carrier + Nitrogenase MoFe maturation protein, NifZ + Putative citrate transporter + Thiopurine S-methyltransferase, Se/Te detoxification + Protein of unknown function DUF3347 + Domain of unknown function DUF1829 + Cobalt transport protein ATP-binding subunit + Energy coupling factor transporter S component ThiW + Outer membrane porin, bacterial + Putative exopolysaccharide exporter + Aminotransferase, LLPSF_NHT_00031 family + Porin, alpha proteobacteria type + Isopropylmalate/citramalate/homocitrate synthase + Glycoside hydrolase, family 37, conserved site + DNA topoisomerase I, N-terminal + Gliding motility-associated lipoprotein GldJ + Protein of unknown function DUF3731 + Gliding-associated putative ABC transporter substrate-binding GldG + Ribosomal protein L39e domain + Uncharacterised protein family UPF0179 + Transcription activator HlyU + Domain of unknown function DUF4395 + Glycogen debranching enzyme, archaeal type + Protein of unknown function DUF5062 + Sodium/proline symporter + Uncharacterised protein family UPF0058 + Ribosome biogenesis factor NIP7-like + Entericidin A/B + LETM1-like + EH signature domain + ABC-2 membrane transporter-like + YukD-like + Protein of unknown function DUF1439 + Transaldolase type 1 + Four helix bundle suffix domain + Bacteriophage Mu, transposase + Reversibly glycosylated polypeptide family + Cytochrome c prime, subgroup + Toxin CcdB + Domain of unknown function DUF1971 + Phage shock protein B + YrhK domain + Lactoylglutathione lyase + Phosphonate C-P lyase system, PhnL + Type VI secretion system, FHA domain-containing protein + Type VI secretion system, lipoprotein SciN + Glycoside hydrolase family 26 + Putative phage-type endonuclease + Plasmid partitioning protein, RepA + Plasmid partitioning protein, RepB + Uncharacterised conserved protein UCP033199 + YMGG-like Gly-zipper + Domain of unknown function DUF4942 + Transcription initiation factor Rrn7, Zinc-finger + Lipase EstA/Esterase EstB + Protein of unknown function DUF4912 + Sporadically distributed protein CHP04141 + Daunorubicin resistance ABC transporter membrane protein + TraU + Methyl-coenzyme M reductase, alpha subunit, N-terminal subdomain 1 + CRISPR-associated protein Csd2 + Cystathionine beta-lyase, bacterial + Flavin monooxygenase FMO + Protein of unknown function DUF4845 + Pyroglutamyl peptidase I, bacterial-type + Lipoyltransferase/lipoate-protein ligase + Putative Na+/H+ antiporter, N-terminal + Protein of unknown function DUF2184 + Protein of unknown function DUF1362 + Protein of unknown function DUF3301 + Bacterioopsin activator-type, HTH domain + Phage/plasmid-like protein + Prokaryotic lipoprotein-attachment site + ADP/ATP carrier protein + Domain of unknown function DUF3859 + Pyridine nucleotide-disulphide oxidoreductase family protein, N-terminal + Gliding motility-associated lipoprotein GldK + Gliding motility-associated, peptidyl-prolyl isomerase, GldI + DEAD/DEAH-box helicase, putative, actinobacteria + Domain of unknown function DUF4236 + Virulence effector, SrfC + Ethanolamine utilisation EutA + Alpha-L-glutamate ligase-related protein + Glycoside hydrolase, family 19, catalytic + Protein of unknown function DUF3367 + Type VIII secretion system, CsgF + Protein of unknown function DUF2922 + Adenylylsulphate reductase, beta subunit + Aerobactin siderophore biosynthesis, IucA/IucC, N-terminal + Shikimate kinase, archaea + Glycosyl transferase, family 17 + GPI mannosyltransferase + Adenosine 5'-phosphosulphate reductase + Gas vesicle protein GvpG + Ribosomal protein L10e + Protein of unknown function DUF3419 + L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase + Gelsolin-like domain + Aconitase B + Protein of unknown function DUF2269, transmembrane + PGF-pre-PGF domain + KfrA, N-terminal DNA-binding domain + Ribosomal protein S11, archaeal + Protein of unknown function DUF475 + Restriction endonuclease, type II, ApaLI + ABC transporter, choline, permease protein + Acetophenone carboxylase beta subunit/Acetone carboxylase gamma subunit + Phasin, subfamily 1 + CofH family + DnaJ-related protein, N-terminal + Ferredoxin-type protein, NapH/MauN family + Peptidase M10A + Protein of unknown function DUF3095 + Conserved hypothetical protein CHP03546 + Domain of unknown function DUF22 + Chaperone NapD, nitrate reductase assembly + Mga helix-turn-helix domain + Prophage tail endopeptidase + Methyl-coenzyme M reductase, gamma subunit + Protein patched/dispatched + Lipoprotein releasing system, ATP-binding protein + Lipid A biosynthesis lauroyl (or palmitoleoyl) acyltransferase + Serine hydrolase FSH + Protein of unknown function DUF3892 + Acyltransferase ChoActase/COT/CPT + Cysteine desulfurase IscS + L-fucose permease FucP + SWEET sugar transporter + High potential iron-sulphur protein + Chlorophyllase + Ammonia/methane monooxygenase, subunitB, N-terminal + 7-carboxy-7-deazaguanine synthase, Cx14CxxC-type + Peptidase M38, beta-aspartyl dipeptidase + S-adenosyl-L-methionine-dependent methyltransferase, putative + PQQ-dependent dehydrogenase, methanol/ethanol family + Protein of unknown function DUF1272 + Uncharacterised conserved protein UCP012641, putative zinc-binding metallo-peptidase + (+) RNA virus helicase core domain + Protein of unknown function DUF3843 + CRISPR-associated protein Cmr2 + Uncharacterised protein family UPF0114, bacteria + SWIB/MDM2 domain + Type VI secretion system-associated, BMAA0400 + Protein of unknown function DUF3581 + Heme b synthase + LURP1-related protein domain + Bacteroidetes-Associated Carbohydrate-binding Often N-terminal + Pseudouridine synthase, RluA-like + Dihaem cytochrome c + Protein of unknown function DUF3185 + Putative peptidoglycan binding + Beta-galactosidase jelly roll domain + Deoxyribonuclease I + Uncharacterised conserved protein UCP006557 + Outer membrane protein OmpA-like, transmembrane domain + Protein of unknown function DUF2474 + Cyd operon protein YbgT + Coenzyme PQQ biosynthesis protein A + Succinyldiaminopimelate transaminase, DapC, beta/gammaproteobacteria + Domain of unknown function DUF4468 with TBP-like fold + Immunity protein 49 + Pseudaminic acid cytidylyltransferase + CRISPR-associated endonuclease Cas9 + Riboflavin synthase, archaeal + Putative sensor domain + O-GlcNAc transferase, C-terminal + Protein of unknown function DUF365 + Protein of unknown function DUF945 + 7,8-dihydroneopterin aldolase, MptD + Alpha-ribazole phosphatase, CobC + Ribosomal protein L38e + Predicted aminopeptidase + Uncharacterised conserved protein UCP028704, OpgC + Penicillin-binding protein 1B + Protein of unknown function DUF4043 + N-glycosylase/DNA lyase-like + Circularly permuted ATPgrasp domain + RNA methyltransferase, SpoU/TrmH type, C-terminal + Alkylhydroperoxidase/carboxymuconolactone decarboxylase family + Protein of unknown function DUF916, cell surface putative + Flagellar export ATPase FliI, clade 1 + Uncharacterised conserved protein UCP01500 + Protein of unknown function DUF460 + Rhodanase, C-terminal + Cytochrome P460 + NifT/FixU + Alkyl hydroperoxide reductase subunit F + Rhomboid-like serine protease, proteobacteria + Chemotaxis methyl-accepting receptor Tar-related, ligand-binding + Globin, bacterial-like, conserved site + Restriction endonuclease, type II, LlaJI + Uncharacterised protein family, YajG + Uncharacterised conserved protein UCP037266 + Alanine dehydrogenase, Archaeoglobus-type + Restriction endonuclease, type II, HindIII + Putative glycogen debranching enzyme, N-terminal + Protein of unknown function DUF4393 + Z ring-associated protein D, C-terminal domain + Lysine biosynthesis enzyme LysX + Nitrate transporter + Verrucomicrobia /Planctomycetes-restricted protein + Protein of unknown function DUF1290 + Protein of unknown function DUF2321 + Protein of unknown function DUF3106 + Putative methanogenesis marker protein 15 + Domain of unknown function DUF1610 + Gliding motility-associated protein GldM + Restriction endonuclease, type II, HpaII + Protein of unknown function DUF2764 + SGNH hydrolase-type esterase, N-terminal + Protein of unknown function DUF3754 + Piwi domain + Protein of unknown function DUF2193 + PEP-CTERM locus polysaccharide chain length determinant + Putative helix-turn-helix protein, YlxM/p13-like + Protein of unknown function DUF3841 + NifT/FixU barrel-like domain + DNA topoisomerase I catalytic fragment, domain 2 + DOMON domain + Xylose isomerase, bacterial-type + Menaquinone biosynthesis protein MenD, middle domain + Sporulation transcription regulator WhiA, N-terminal domain + O-antigen polysaccharide polymerase Wzy + Conserved hypothetical protein CHP04013, B12-binding/radical SAM-type + Metal-independent alpha-mannosidase + START domain + GvpD gas vesicle + Domain of unknown function DUF4080 + CopG-like ribbon-helix-helix domain + Ionotropic glutamate receptor + DNA primase, small subunit, eukaryotic/archaeal + [NiFe]-hydrogenase assembly, chaperone, HybE + Type II secretion system protein N, Leptospira-type + Baseplate hub assembly protein, bacteriophage T4-like + ATPase, type I secretion system + AHH domain-containing protein + Prokaryotic E2 family D + Macrophage infectivity potentiator + Domain of unknown function DUF4373 + Ribosomal protein L39e + DoxX-like family + Selenium-binding protein + Acyl-CoA thioesterase II domain + Isochorismate synthase + Proliferating cell nuclear antigen, PCNA, conserved site + Domain of unknown function DUF4444 + Domain of unknown function DUF4150 + Acetyl-coenzyme A transporter 1 + Domain of unknown function DUF2134, membrane + HAD-superfamily phosphatase, YqeG-like + Peptidase M64, N-terminal + LRAT-like domain + DNA-directed RNA polymerase, 30-40kDa subunit, conserved site + HTH-type transcriptional regulator ArgP + Cellulose synthase, subunit A + Aromatic amino acid hydroxylase, iron/copper binding site + Protein of unknown function DUF314 + Transcriptional regulator SgrR, N-terminal HTH domain + Membrane bound YbgT-like + Photosynthetic reaction centre, L/M + Putative RNA methyltransferase + Protein of unknown function DUF1810 + Dihydrolipoamide acetyltransferase pyruvate dehydrogenase complex + ATP-dependent DNA helicase Rep + Homoserine kinase, type II + Domain of unknown function DUF4166 + Uncharacterised conserved protein UCP018781, methanogenesis + Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site + ADP ribosyltransferase + Conserved hypothetical protein CHP02206, TP0381 + Type II secretion system, protein N + Gliding motility-associated ABC transporter ATP-binding subunit GldA + Phospholipase D/Transphosphatidylase + Putative monooxygenase YdhR + TyrR family, helix-turn-helix domain + Protein of unknown function DUF3780 + Lytic transglycosylase MltB + Putative oxidoreductase, C-terminal + Methyl-coenzyme M reductase, beta subunit, C-terminal + Dihydroxyacetone kinase phosphotransferase subunit, N-terminal domain + Uncharacterised conserved protein UCP019464, methanogenesis + Bacteriophage holin family + Methyl-coenzyme M reductase, protein C + Protein of unknown function DUF3379 + Ubiquitin domain + CRISPR-associated protein, CXXC-CXXC + Nitrate reductase cytochrome c-type subunit NapB + Conserved hypothetical protein CHP02449 + Protein of unknown function DUF2288 + DnaQ exonuclease/DinG helicase, predicted + Atu1913-like + ABATE domain + Protein of unknown function DUF4846 + Phosphatidylinositol 3-/4-kinase, catalytic domain + Domain of unknown function DUF4986 + Protein of unknown function DUF4465 + Trans-aconitate 2-methyltransferase, C-terminal + Glucose-fructose oxidoreductase, bacterial + Glycyl radical enzyme, HI0521, predicted + Protein of unknown function DUF2252 + 2OG-Fe dioxygenase + L-threonine 3-dehydrogenase + Domain of unknown function DUF2268 + Transcription factor 25 + Serine dehydratase, alpha subunit + DNA-binding protein Tfx, archaea + Ubiquinol-cytochrome c chaperone/UPF0174 + Nitrogenase component 1, alpha chain + Ribosomal protein L6, conserved site-2 + Type VI secretion system-associated, VCA0118 + Berberine/berberine-like + Beta-lactamase, class-A + Protein of unknown function DUF4402 + Quinoprotein dehydrogenase, conserved site + Choline ABC transporter, substrate-binding protein + Undecaprenyl-phosphate galactose phosphotransferase, WbaP + Protein of unknown function DUF3297 + Methyl coenzyme M reductase system, component A2 + Domain of unknown function DUF2183 + Mycothiol-dependent maleylpyruvate isomerase, metal-binding domain + tRNAHis guanylyltransferase catalytic domain + Exosortase F-associated protein + Vps4 oligomerisation, C-terminal + Conserved hypothetical protein CHP04096 + Recombination-promoting nuclease RpnA + Type II secretion system protein B + Flagellar assembly protein T, middle domain + Urea transporter + CASTOR/POLLUX/SYM8 ion channels + Restriction endonuclease, type II, TaqI + Formate dehydrogenase, delta subunit + Protein of unknown function DUF1465 + 5-nucleotidase lipoprotein e(P4) + Chitin binding domain + Protein of unkown function DUF2303 + Flagellar hook-length control protein FliK + Homoprotocatechuate degradation transcriptional regulator HpaR + Fe/S biogenesis protein NfuA + Transcription factor HTH, IscR + PBP-dependent ABC transporters TM subunit, N-terminal + Methyl-coenzyme M reductase, beta subunit, N-terminal + von Hippel-Lindau disease tumour suppressor, beta domain + Modulator of Rho-dependent transcription termination + Sporulation stage 0, protein M + Glycogen synthase + Coiled stalk of trimeric autotransporter adhesin + Winged helix-turn-helix domain (DUF2582) + Protein of unknown function DUF4287 + ATP binding protein MinD, archaea + Protein of unknown function DUF501 + Protein of unknown function DUF4326) + Nucleotide-diphospho-sugar transferase + Putative methionine gamma-lyase + Frataxin/CyaY + Protein of unknown function DUF2865 + Domain of unknown function DUF3291 + Ribosomal protein L35A + Protocatechuate 3,4-dioxygenase beta subunit, N-terminal + Type VI secretion system-associated, ImpA + ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydD + Protein of unknown function DUF2165, transmembrane + Exopolyphosphatase + 12,18-Didecarboxysiroheme deacetylase + DNA-directed RNA polymerase M, 15kDa subunit, conserved site + Ribosomal protein L31e, conserved site + Spondin, N-terminal + YaaC-like protein + Membrane-associated sensor domain MASE3 + Tetracycline regulation of excision, RteC + Protein of unknown function DUF4864 + Domain of unknown function DUF2172 + TonB-dependent haem/haemoglobin receptor + Glycoside hydrolase, family 62, arabinosidase + Cyclic dehypoxanthine futalosine synthase + C-terminal of Roc (COR) domain + Glucokinase ROK + Domain of unknown function DUF3502 + Uncharacterised protein family Smp + Sulphur transferase DndC, putative + Allantoinase + Opacity-associated protein A, N-terminal + Carbonic anhydrase, alpha-class, conserved site + Protein of unknown function DUF4437 + Molybdate transporter 1/2 + Chitobiase/beta-hexosaminidases, N-terminal domain + ABC transporter, substrate-binding protein, PQQ-dependent alcohol dehydrogenase system + YfbU, alpha-helical bundle domain + Oxidoreductase alpha (molybdopterin) subunit + Ribosomal protein S19e, conserved site + Peptidase S15, X-Pro dipeptidyl-peptidase + Protein of unknown function DUF2497 + Dihydroneopterin aldolase MtpD, C-terminal domain + Beta-lactamase, class-C active site + Toxin SymE-like + CRISPR-associated helicase, CYANO-type + Cytochrome b562 + Protein of unknown function DUF2947 + Protein of unknown function YvrJ + Tryptophan/tyrosine transporter + Transferrin receptor-like, dimerisation domain + Type II secretion system protein L + Domain of unknown function DUF4423 + Fimbrial isopeptide formation D2 domain + o-Succinylbenzoate synthase, MenC type 2 + Uncharacterised conserved protein UCP006577 + Domain of unknown function DUF1854 + Sulfopyruvate decarboxylase, beta subunit + Sugar transferase, PEP-CTERM system associated + Poly-gamma-glutamate hydrolase + Protein of unknown function DUF3081 + Protein of unknown function DUF3087 + Arginine N-succinyltransferase + Methyl-coenzyme M reductase, alpha subunit, C-terminal + Protein of unknown function DUF1700 + Dissimilatory sulphite reductase D + Chlamydiae/Verrucomicrobia/Planctomycetes small basic protein + Negative modulator of initiation of replication SeqA, N-terminal + Tail tubular protein Gp11 + Domain of unknown function DUF2828 + Phage shock protein, PspC + Carbohydrate-binding module family 5/12 + YheA/YmcA-like domain + Phosphonoacetate hydrolase, insert domain + Phosphotransferase system, IIA-like nitrogen-regulatory protein PtsN + GPI transamidase subunit PIG-U + Prokaryotic E2 family B + Protein of unknown function DUF2585 + Domain of unknown function DUF2760 + CRISPR-associated protein Csy2 + CRISPR-associated endoribonuclease Cas6/Csy4, subtype I-F/YPEST + Phosphonate metabolism PhnM + Non-homologous end joining protein Ku, prokaryotic type + Homocitrate synthase NifV-type + Polysaccharide lyase family 8, C-terminal + Conserved hypothetical protein CHP03032 + Fatty acid response transcription factor FadR + Domain of unknown function DUF4815 + Meso-diaminopimelate D-dehydrogenase, C-terminal + Helicase, SWF/SNF/SWI type, bacterial + Lipopolysaccharide-modifying protein + Golgi phosphoprotein 3-like + ISC system FeS cluster assembly, HscA chaperone + Sedoheptulose-1,7-bisphosphatase + Protein of unknown function DUF2809 + Gliding motility-associated ABC transporter permease protein GldF + COX aromatic rich motif + Protein of unknown function DUF3796 + Putative polyhydroxyalkanoic acid system protein + Cysteine desulfurase-related, unknown function + Propanediol/glycerol dehydratase, small subunit + Cytochrome c oxidase caa3-type, assembly factor CtaG-related + Monooxygenase component MmoB/DmpM + Pilus assembly TraE + Bacteriophage regulatory protein, Rha family + Nitrogen fixation protein NifW + Tocopherol cyclase + Beta-lactamase, class-D active site + Malate dehydrogenase, type 2 + LOR/SDH bifunctional enzyme, conserved domain + Rhamnogalacturonan lyase, domain III + Domain of unknown function DUF1727 + Phenylalanine-4-hydroxylase, monomeric form + Bacteriophage A500, Gp15 + L-lactate dehydrogenase, active site + Protocatechuate 3,4-dioxygenase, beta subunit + Zinc finger, C4 DksA/TraR-type + Type II pantothenate kinase + Protein of unknown function DUF4331 + Potassium channel, voltage-dependent, EAG/ELK/ERG + Chalcone/stilbene synthase, N-terminal + Cysteine-rich Golgi apparatus protein 1 repeat + Putative methanogenesis marker protein 1 + Conserved hypothetical protein CHP01626, YtfJ + Protein of unknown function DUF2513 + Conserved hypothetical protein CHP1671 + Protein of unknown function DUF3019 + CoB--CoM heterodisulphide reductase, subunit C + Bacteriophage lambda, Nu1, terminase small subunit + CRISPR-associated protein, TM1791 + Domain of unknown function DUF5001 + HupH hydrogenase expression protein, C-terminal + Cryptochrome DASH + Arginase + Methylaspartate ammonia-lyase + Protein of unknown function DUF4867 + Putative beta-lactamase-inhibitor-like, PepSY-like + Oxidoreductase-like, N-terminal + Protein of unknown function DUF3261 + 5,10-methylenetetrahydromethanopterin reductase + Glutaredoxin 2, C-terminal + Pyrrolysine biosynthesis protein PylD + Protein beta + Cytochrome c-550 PedF + Antitoxin of toxin-antitoxin, RelE / RelB, TA system + Beta-lactamase, class-A active site + Probable Zinc-ribbon domain + Outer membrane beta-barrel protein, Proteobacteria + Adenylate cyclase class-I, N-terminal domain + Holliday junction resolvase RecU + GDYXXLXY protein + Major outer membrane lipoprotein Oprl + Pyrrolysine biosynthesis protein PylC + Formate-dependent phosphoribosylglycinamide formyltransferase + Protein of unknown function DUF2938 + Histidine N-alpha-methyltransferase + S-adenosyl-L-methionine dependent methyltransferase, SAV2177 type + 2-polyprenyl-6-methoxyphenol 4-hydroxylase + Luciferase-like, F420-dependent oxidoreductase, Rv2161c, predicted + Sugar transferase, PEP-CTERM, Stp1 + Archaeosortase A + DNA-packaging protein gp3 + Peptidase S54, GlpG peptidase, N-terminal + Domain of unknown function DUF2470 + Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase, domain N/S + Prokaryotic Ubiquitin + Ribosomal protein S26e + Ribosomal protein S4e, N-terminal, conserved site + Barstar (barnase inhibitor) + Succinylglutamate-semialdehyde dehydrogenase + RNA polymerase, subunit H/Rpb5, conserved site + DOPA-like domain + PEF-CTERM protein sorting domain + Uncharacterised conserved protein UCP019322 + Phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein + CDKN3 domain + Ribosomal protein L30e, conserved site + Sulfopyruvate decarboxylase, alpha subunit + Homing endonuclease PI-Sce + Histone-like protein H-NS family, oligomerisation domain + Phosphoribosylaminoimidazole-succinocarboxamide synthase, Vibrio-type + Uncharacterised protein family UPF0304, YfbU + Protein of unknown function DUF2273 + Gas vesicle protein GvpN + Tir chaperone protein (CesT) family + Host-nuclease inhibitor protein Gam + Hexameric tyrosine-coordinated heme protein (HTHP) + Alkyl hydroperoxide reductase subunit C + Ammonia monooxygenase/particulate methane monooxygenase, subunit A + Protein of unknown function DUF975 + Type II secretion system protein C + L-rhamnose mutarotase + Type VI secretion system, ATPase ClpV1 + Histidine utilization repressor + Putative rRNA methylase + Uncharacterised protein family Rv2561 + DNA ligase D, polymerase domain + CRISPR-associated protein Csc1 + Citrate lyase acyl carrier protein CitD + Uncharacterised protein family UPF0060 + DNA helicase + Uncharacterised conserved protein UCP033924 + Conserved hypothetical protein CHP02594 + Domain of unknown function DUF4957 + Phosphoenolpyruvate phosphomutase, core + Phycobilisome, alpha/beta subunit + Ribosomal protein L5 eukaryotic/L18 archaeal, C-terminal + Dopa 4,5-dioxygenase + Pimeloyl-[acyl-carrier protein] methyl ester esterase + Protein of unknown function DUF3050 + Protein of unknown function DUF3526 + Chalcone/stilbene synthase, C-terminal + Ribosomal protein Rsm22-like + Uncharacterised protein family UPF0489 + Protein of unknown function DUF3016 + Spore coat protein U + Protein of unknown function DUF326 + Protein of unknown function DUF1961 + Curli assembly protein CsgE + HAD-superfamily phosphatase, subfamily IIIC + UDP-galactopyranose mutase + Cell division suppressor protein, SulA + Uncharacterised protein family PGPGW, transmembrane + Secretin, N-terminal + Protein of unknown function DUF2813 + Protein of unknown function DUF3575 + FAD-binding, type 1 + Capsid assembly scaffolding protein + Molybdenum cofactor cytidylyltransferase + Alternate ATP synthase, F0complex, subunit A + Protein of unknown function DUF2782 + CDP-alcohol phosphatidyltransferase, C-terminal + Type IV conjugative transfer system, protein TraL + Bacteriophage B3, Orf6 + SWIM/SEC-C metal-binding motif protein, PBPRA1643 family + Domain of unknown function DUF4234 + Protein of unknown function DUF4231 + 5-Dehydro-2-deoxygluconokinase + Metaxin, glutathione S-transferase domain + Primosomal replication PriB/PriC + Nuclease-associated modular DNA-binding 1 + Protein of unknown function DUF469 + Uncharacterised protein family YebG + Protein Veg + Phosphate ABC transporter, substrate-binding protein PstS + ABC transporter, Choline, ATP-binding subunit + 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, gammaproteobacteria + Chitinase insertion domain + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase + Protein of unknown function DUF1003 + Phage P22-like portal protein + Nitrous-oxide reductase + Protein of unknown function DUF1203 + Protein of unknown function DUF2919 + 3,5/4-Trihydroxycyclohexa-1,2-dione hydrolase + Uncharacterised protein family UPF0460 + Concentrative nucleoside transporter, metazoan/bacterial + 6-phosphogluconate dehydrogenase, YqeC-type + CRISPR-associated protein Cas5, Tneap type + Helix hairpin bin domain + D-arabinono-1,4-lactone oxidase + Protein of unknown function DUF2982 + Myc-type, basic helix-loop-helix (bHLH) domain + Protein of unknown function DUF331 + GRAM domain + Tail tube protein + Methyltransferase MtaA/CmuA + Ferrichrome-binding periplasmic protein + Diaminopimelate dehydrogenase, Ddh + Ribosomal biogenesis, methyltransferase, EMG1/NEP1 + Bacteriophage Mu-like, Gp48 + Conserved hypothetical protein CHP02099 + Restriction endonuclease, type II, MunI + Protein of unknown function DUF3052 + Methylmalonyl-CoA mutase small subunit, N-terminal + ABC cobalt transporter + SO1590-like domain + Protein of unknown function DUF2989 + Protein of unknown function DUF3012 + Pilus biogenesis CpaD-related + Putative sugar diacid recognition + Sensor DegS + SprT-like, zinc ribbon domain + Nickel/cobalt homeostasis protein RcnB + Pilus biogenesis, MshL + Phage minor structural protein, N-terminal domain + FaeA-like protein + Ribosomal protein L7Ae conserved site + Sensor protein KdpD, transmembrane domain + Protein of unknown function DUF1841 + Protein of unknown function DUF3100 + ArsR transcriptional regulator + Putative methanogenesis marker 16 metalloprotein + Putative methanogenesis marker 13 metalloprotein + Phosphonoacetaldehyde hydrolase + Restriction endonuclease, type II, EcoRII, N-terminal + PEP-CTERM system-associated, FemAB-related + Restriction endonuclease, type II, NgoFVII + Restriction endonuclease, type II, MamI + Cytochrome oxidase assembly protein 1 + Glycosyl hydrolase family 67, C-terminal + Protein of unknown function DUF4186 + Nif-specific regulatory protein + Domain of unknown function DUF3943 + CRISPR-associated protein Csy3 + Decahaem-associated outer membrane protein, MtrB/PioB + YEATS + 2-methylisocitrate dehydratase AcnD, Fe/S-dependent + Uncharacterised protein family UPF0288, methanogenesis + Phosphonate C-P lyase system, PhnK + Formiminoglutamate deiminase + Methylthioribose kinase + Virulence factor SrfB + Domain of unknown function DUF3463 + Protein of unknown function DUF3149 + Protein of unknown function DUF991 + Protein of unknown function DUF996 + Flagellar protein FliT + Protein of unknown function DUF4336 + Xylose isomerase, actinobacteria + Protein of unknown function DUF3782 + Domain of unknown function DUF3821 + Virulence-related outer membrane protein + Bacteriophage VT1-Sakai, H0025 + Conserved hypothetical protein CHP00661 + CRISPR-associated protein, CXXC-CXXC domain + Enoyl-(acyl-carrier-protein) reductase II, putative + Uncharacterised conserved protein UCP07580 + Transposase, ISC1217 + Translation Initiation factor eIF- 4e-like + Domain of unknown function DUF4041 + Nucleolar GTP-binding protein 1, Rossman-fold domain + CHRD + ABA DEFICIENT 4-like + Transcription regulator, HipB-like + Heme D1 biosynthesis, radical SAM protein NirJ + Spore germination GerAC + Proline-specific peptidase + Phosphogluconate dehydrogenase, NAD-binding, putative, C-terminal + Phytochrome, central region + Pectate lyase + Bacteriophage Mu, Gp16 + Pyroglutamyl peptidase I, Glu active site + Conserved hypothetical protein CHP03097, O-antigen ligase-related + Bacterial toxin, RNase RnlA/LsoA + SigmaK-factor processing regulatory BofA + Uncharacterised protein family Ycf35 + Cellulose/chitin-binding protein, N-terminal + YTV + Anti sigma-E protein RseA, C-terminal + Hypoxanthine-DNA glycosylase + Restriction endonuclease, type II, FokI, C-terminal + Protein of unknown function DUF4380 + UCP01524, winged helix-turn-helix domain + Protein of unknown function DUF3500 + Acyl-CoA thioesterase + PEP-CTERM system TPR-repeat lipoprotein, putative + Protein of unknown function with HXXEE motif + Tetrahydromethanopterin S-methyltransferase subunit A, MtrA + DNA partition complex, ParG + Protein of unknown function DUF4892 + Uncharacterised protein family UPF0259 + Pup ligase/deamidase + Cysteate synthase + Protein of unknown function DUF1749 + Uncharacterised conserved protein UCP006600 + Uncharacterised conserved protein UCP006598 + Salmonella virulence plasmid 65kDa B protein + Na+-dependent bicarbonate transporter superfamily + Conserved hypothetical protein CHP00375 + Anaerobic c4-dicarboxylate membrane transporter + Restriction endonuclease, type II, EcoRI + Outer membrane usher protein + Putative glycyl-radical enzyme activating enzyme YjjW + Uncharacterised protein family UPF0248 + Blue (type 1) copper protein, binding site + ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system + PLAT/LH2 domain + Uncharacterised protein family UPF0231 + Protein of unknown function DUF2225 + Protein of unknown function DUF2391 + Histone H1-like Hc1 + PilZ domain, deltaproteobacteria + RimK-like ATPgrasp N-terminal domain + Poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, C-terminal + Restriction endonuclease, type II, BamHI + Sucrose synthase + Low temperature requirement A + Zinc finger, Ogr/Delta-type + Tannase/feruloyl esterase + Protein of unknown function DUF3375 + Beta-galactosidase, domain 2 + Glycine reductase complex selenoprotein A + NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family + DNA repair protein, predicted + Conserved hypothetical protein CHP02450, tryptophan-rich + D-lysine 5,6-aminomutase beta subunit KamE, N-terminal + Phospholipase B-like + Oligogalacturonate-specific porin + Cysteine desulfurase-related + Alpha-galactosidase, NEW1 domain + Domain of unknown function DUF3858 + Domain of unknown function DUF4203 + PEP-CTERM/exosortase system-associated acyltransferase, predicted + Chorismate pyruvate-lyase Rv2949c-like + Catechol 2,3 dioxygenase + Ribosomal protein S28e conserved site + Domain of unknown function DUF1947 + Uncharacterised conserved protein UCP029037 + E3 Ubiquitin ligase, GIDE-type + Glycerate/sugar phosphate transporter, conserved site + UDP-glucuronosyl/UDP-glucosyltransferase + Ethanolamine utilisation EutJ + Protein of unknown function DUF4826 + Ceramidase + PsbP family + Domain of unknown function DUF4399 + Domain of unknown function DUF4398 + Protein of unknown function DUF4403 + Phosphotransferase system, lactose/cellobiose-type IIA subunit + Serine carboxypeptidase, serine active site + GDP dissociation inhibitor + Putative general bacterial porin + Pseudomurein-binding repeat + Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase, N-terminal + Bacteriophage T7, Gp3, endodeoxynuclease I + Protein of unknown function DUF3718 + Thiol-activated cytolysin + 4Fe-4S binding protein, C-terminal + Alpha-1,6-glucosidases, pullulanase-type, C-terminal + Copper resistance lipoprotein NlpE + Transcription activator PspF + Adenosine/AMP deaminase active site + Acetyl/Succinylornithine transaminase family, bacteria + Protein of unknown function DUF2617 + LruC domain + DHHW protein + Hydroxymethylglutaryl-CoA lyase, active site + Natural product biosynthesis luciferase-like monooxygenase domain + Conserved hypothetical protein CHP03545 + Protein of unknown function DUF2119 + Protein of unknown function DUF2279, periplasmic lipoprotein + SUF system FeS cluster assembly regulator + Na+/H+ exchanger + Methyl-coenzyme M reductase, beta subunit + Benzoyl-CoA reductase, bzd-type, O subunit + CRISPR-associated protein APE2256 + Domain of unknown function DUF4921 + N-formylglutamate deformylase + Uncharacterised protein family AF1218 + Protein of unknown function DUF4256 + LssY-like C-terminal domain + Protein of unknown function DUF3137 + Pyrrolysyl-tRNA ligase, C-terminal + DNA-binding RFX-type winged-helix domain + Glycerol-3-phosphate acyltransferase, PlsB + Gas vesicle protein GvpO + Protein of unknown function DUF3313 + Outer membrane protein + Conserved hypothetical protein CHP00155 + NADH dehydrogenase subunit 5, C-terminal + Type VI secretion system-associated, VCA0119 + Mini-chromosome maintenance, conserved site + Sorbitol phosphotransferase enzyme II, N-terminal + DNA-directed RNA polymerase, N-terminal + Phenylacetate degradation probable enoyl-CoA hydratase PaaB + Ribosomal peptide maturation radical SAM protein 1 + TraX + PIN domain toxin + Conserved hypothetical protein CHP00300 + Dihydropteroate synthase-related protein synthase-related protein + ParB-related, ThiF-related cassette, protein C + Beta-N-acetylglucosaminidase + MepB-like + Protein of unknown function DUF2868 + Cysteine-rich CWC + Cytochrome o ubiquinol oxidase subunit IV + Arrestin-like, N-terminal + Cobaltochelatase subunit, putative + Protein of unknown function DUF3037 + FkbH domain + Domain of unknown function DUF4350 + Methyl-coenzyme M reductase, protein D + Protein of unknown function DUF3334 + Plasmid encoded RepA protein + GMP reductase + Aminodeoxyfutalosine synthase + Phycobilisome linker domain + WW domain + Aconitase, mitochondrial-like + Plasmid segregation protein ParM/StbA + Calcineurin-like phosphoesterase, N-terminal + Archaeal/bacterial/fungal rhodopsins + Uncharacterised conserved protein UCP005642, methanogenesis + Ferredoxin-type protein NapF + Ribosomal protein L34Ae + Putative ABC transporter periplasmic binding protein PhnD-like + Alcohol dehydrogenase, insect-type + 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase, N-terminal + 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase, DapH + Exosortase H, IPTLxxWG-CTERM-specific + Zinc finger, ZPR1-type, subgroup + Conserved hypothetical protein CHP04014, B12-binding/radical SAM-type + Domain of unknown function DUF2236 + Protein of unknown function DUF485 + Glutamate mutase E subunit, C-terminal domain + Ribosomal protein S17e, conserved site + Ethanolamine utilisation EutQ + HD-related protein + Bacteriophage tail protein Gp41, putative + Pullulanase, carbohydrate-binding module 41 + Dpy-19/Dpy-19-like + Protein of unknown function DUF2956 + Protein of unknown function DUF2939 + Glycosyl hydrolase family 67, catalytic domain + YtkA-like domain + Integral membrane protein YccS, N-terminal + Allophanate hydrolase + Peptidase S51, cyanophycinase + 6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase + Conserved hypothetical protein CHP03492 + IMP cyclohydrolase + Protein of unknown function DUF968 + TfuA-like, core + Protein of unknown function DUF2090 + Stimulus-sensing domain + Cytochrome c, class ID + Peptidase A31, hydrogenase expression/formation protein + Protein of unknown function DUF2999 + Lipase, secreted + Zinc finger, CCHC-type + Protein of unknown function DUF1036 + Radical SAM, TatD-associated + Protein of unknown function DUF413 + Aspartate 1-decarboxylase, pyridoxal-dependent + Invasin, domain 3 + Chs5p-Arf1p binding + SPW repeat + Sterol-sensing domain + Protein of unknown function DUF4914 + Aerobic respiration control sensor protein ArcB, transmembrane domain + Conserved hypothetical protein CHP02147 + CRISPR associated protein Csc3 + Domain of unknown function DUF695 + [FeFe]-hydrogenase maturation HydG, radical SAM + ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydC + CRISPR-associated protein Cas1, DVULG subtype + Thiazole biosynthesis ThiH + Methyltransferase domain, putative + Protein of unknown function DUF3126 + Prenyl protease-related + Protein of unknown function DUF3630 + Protein of unknown function DUF3265 + Plasminogen-binding protein PgbA, N-terminal + PfaD family protein + FeS assembly SUF system protein SufT, putative + Biofilm formation YgiB + Protein of unknown function DUF1192 + Protein of unknown function DUF3616 + Protein of unknown function DUF3732 + Protein of unknown function DUF2226 + Restriction endonuclease, type II, Bsp6I + Bromodomain + Alternate ATP synthase, F1 complex, subunit alpha + Protein of unknown function DUF4404 + Type IV secretion system, VirB5 + NIDO domain + Putative exonuclease, DNA ligase-associated + Strawberry notch, helicase C domain + Acetyl-CoA C-acyltransferase FadA + PhoP regulatory network protein YrbL + Formiminoglutamase + Phage tail fibre protein + Protein of unknown function DUF3320 + Ferritin-like protein + Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase + PAS fold-2 + PucC-related + Protein of unknown function DUF1656 + Helicase, superfamily 3, single-stranded DNA/RNA virus + CRISPR-associated protein, NE0113 + TonB-dependent haemoglobin/transferrin/lactoferrin receptor + Glucose-1-phosphate adenylyltransferase, GlgD subunit + ATPase, V0 complex, c subunit + Conjugative relaxase, N-terminal + RNA polymerase, Rpb5, N-terminal + Putative methanogenesis marker protein 2 + Usg-like + Putative purine nucleotide phosphorylase + BA14k family + Protein of unknwon function DUF3008 + Protein of unknown function DUF2897 + Zinc finger, PARP-type + Cobalamin-independent methionine synthase + Acetyl-S-ACP:malonate ACP transferase + Iron-sulphur-dependent L-serine dehydratase beta subunit + Protein of unknown function DUF3335 + Peptidase A26, omptin + Myoviridae tail sheath stabiliser + Photosystem I PsaA/PsaB + Two pore domain potassium channel + PD(D/E)XK endonuclease + Aliphatic sulfonates-binding protein + Domain of unknown function DUF642 + Protein of unknown function DUF995 + Protein of unknown function DUF600 + LEM/LEM-like domain + Peptidase family M60 domain + Protein of unknown function DUF3560 + CoB--CoM heterodisulphide reductase, subunit B + DNA polymerase III, psi subunit + Protein of unknown function DUF459 + Cell division protein ZapC + 3-oxoacyl-(acyl-carrier-protein) reductase, putative + Ribosomal protein S8e, conserved site + Ribonuclease III, archaeal + Dinitrogenase iron-molybdenum cofactor, N-terminal + Tyrosyl-DNA phosphodiesterase I + Protein of unknown function DUF4492 + Bacillus/Clostridium Ger spore germination protein + Domain of unknown function DUF4071 + Protein of unknown function DUF3240 + Uncharacterised domain, helicase/relaxase, putative + Accessory gene regulator B + Doublecortin domain + Maltose transport system permease protein MalF, P2 domain + Domain of unknown function DUF4443 + Control of competence regulator ComK, YlbF/YmcA + RTX toxin-activating protein C, bacteria + Domain of unknown function DUF4032 + Protein of unknown function DUF1367 + YejL-like domain + 2-hydroxymuconic semialdehyde dehydrogenase + Ribosomal S24e conserved site + YfbU, helix-hairpin domain + Protein of unknown function DUF4128 + RNA chaperone ProQ, C-terminal + Cytochrome o ubiquinol oxidase subunit II + DNA polymerase III-theta, bacterial + Protein of unknown function DUF1475 + Futalosine hydrolase + Transcription regulator QacR, C-terminal + RNA ligase T4 Rnl1, N-terminal + Domain of unknown function DUF4397 + Copper type II, ascorbate-dependent monooxygenase-like, C-terminal + Protein of unknown function DUF5063 + Sulphate ABC transporter, permease protein CysT + Myoviridae, GpU + Protein of unknown function DUF3721 + Nitrogenase molybdenum-iron protein beta chain, N-terminal + Poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit + Phage shock protein, PspA + Conserved hypothetical protein CHP03987 + Peptide-modifying radical SAM enzyme putative, AF0577 + Uncharacterised protein family UPF0208 + Antirestriction protein + Protein of unknown function DUF2170 + Gram-positive LPXTG cell wall anchor + Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase + Restriction endonuclease, type II, Eco47II + Putative O-antigen polymerase + Zinc finger, RING-type + Lycopene cyclase domain + Endoplasmic reticulum resident protein 29, C-terminal + Regulator of ribonuclease activity A, gammaproteobacteria + Protein of unknown function DUF1924 + Hydroxymethylpyrimidine transporter CytX + Conserved hypothetical protein CHP02646 + Thymidine phosphorylase + Streptogrisin prodomain + MauM/NapG ferredoxin-type protein + Bacterial virulence factor lipase, N-terminal domain + Ribose-1,5-bisphosphate isomerase, e2b2 family + Protein of unknown function DUF922 + 4-carboxy-4-hydroxy-2-oxoadipate aldolase/oxaloacetate decarboxylase + Domain of unknown function DUF1535 + DNA replication regulator, HobA + Polysaccharide pyruvyl transferase, CsaB + Catechol dioxygenase, N-terminal + Fructose-2,6-bisphosphatase + Protein of unknown function DUF4935 + Protein of unknown function DUF2093 + Protein of unknown function DUF2095 + Bacteriophage P22, Gp10, DNA-stabilising + Replication-associated protein G2P, N-terminal + Protein of unknown function DUF3135 + Protein of unknown function DUF4279 + Cytochrome c nitrite reductase, small subunit + Glutaredoxin, GrxA + Glutaredoxin domain + Malonyl-[acyl-carrier protein] O-methyltransferase BioC + Zinc finger, MYM-type + 2-isopropylmalate synthase + Domain of unknown function DUF4347 + Cobalamin biosynthesis central region + Putative membrane-bound dehydrogenase + NifQ + Beta-1,3-glucanase, N-terminal + Protein of unknown function DUF2787 + Domain of unknown function DUF4329 + Pilus assembly TraK + Protein of unknown function DUF3332 + CRISPR-associated protein GSU0053 + Frataxin conserved site + Betaine aldehyde dehydrogenase + Quinohemoprotein amine dehydrogenase, alpha subunit domain III + Putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE + Putative 4-mercaptohistidine N1-methyltranferase, OvoA C-terminal domain + Protein of unknown function DUF3283 + Zinc finger, LIM-type + Prokaryotic E2 family A + Protein of unknown function DUF1059 + Putative nucleotidyltransferase + Domain of unknown function DUF2169 + PQQ-dependent catabolism-associated CXXCW motif + ZinT domain + Protein of unknown function DUF3034 + Cd(II)/Pb(II)-responsive transcriptional regulator + VirC1 + Uncharacterised protein family UPF0311 + Fatty oxidation complex, alpha subunit FadB + Putative cellulase + ATPase, A1A0, subunit H + Tryptophan RNA-binding attenuator protein domain + Septum formation inhibitor MinC, N-terminal + 3,4-dihydroxyphenylacetate 2,3-dioxygenase + Uncharacterised protein family UPF0352 + Chorismate mutase, T-protein + PqqD family protein, HPr-rel-A system + Prokaryotic chromosome segregation/condensation protein MukE + Restriction endonuclease, type II, NgoPII + Fructose-1,6-bisphosphatase class 3 + TQO small subunit DoxD + Protein of unknown function DUF3465 + Domain of unknown function DUF5077 + Integrase catalytic domain, putative + Putative integrase, N-terminal + [NiFe]-hydrogenase maturation factor HyaE + Domain of unknown function DUF1993 + Conserved hypothetical protein CHP02096 + Chitobiase C-terminal domain + Protein-tyrosine phosphatase, SIW14-like + Frag1/DRAM/Sfk1 + Protein of unknown function DUF4054 + Domain of unknown function DUF1206 + Protein Gp5, N-terminal OB-fold domain + SynChlorMet cassette protein ScmC + Protein of unknown function DUF2239 + Protein of unknown function DUF3866 + Protein of unknown function DUF2496, YbaM-related + KaiA/RbsU helical domain + Hedgehog protein, Hint domain + Protein AmpE + PKD/REJ-like domain + Rhomboid protease GlpG + Glycoside hydrolase, family 13, N-terminal Ig-like domain + Radical SAM enzyme, MSMEG0568 + Protein of unknown function DUF432 + Helicase-associated + Domain of unknown function DUF1902 + Uncharacterised conserved protein UCP010219 + Protein of unknown function DUF3224 + Protein GvpH + Protein of unknown function DUF1375 + Methionine repressor MetJ domain + Protein of unknown function DUF1849 + Carboxylate/Amino Acid/Amine Transporter + LL-diaminopimelate aminotransferase + TMEM220 protein + Putative beta barrel porin-7 + Multi-ubiquitin domain + Methyltransferase regulatory domain, predicted + Protein of unknown function DUF3006 + Alpha-N-acetylglucosaminidase, tim-barrel domain + PRMT5, oligomerisation domain + rRNA-processing protein Fcf1/Utp23 + Protein of unknown function DUF1864 + DNA helicase IV, N-terminal domain + CRISPR-associated RAMP BGP1436 + Carbohydrate binding module, xylan-binding domain + Aspartate 4-decarboxylase + Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal + Domain of unknown function DUF4328 + Putative phage integrase + Protein of unknown unction DUF1444 + SLC12A transporter, C-terminal + Membrane protein GlpM/YdgC + N-acetyl-gamma-glutamyl-phosphate reductase, type 2 + CRISPR-associated protein Cas1, YPEST subtype + Protein of unkown function DUF2523 + ATP adenylyltransferase, C-terminal + Plasmid recombination enzyme + Transcription attenuation protein MtrB + Type IV conjugative transfer system protein TraV + Protein of unknown function DUF1107 + Domain of unknown function DUF2510 + Phosphotransferase system, glucitol/sorbitol-specific IIA component + Protein of unknown function DUF3545 + Domain of unknown function DUF3322 + Serine proteases, V8 family, serine active site + Anthranilate synthase component I, archaeal type + Haem NO binding associated + Alkylmercury lyase + Ribosomal protein S25 + Protein of unkown function DUF3268 + Energy-coupling factor transporter ATP-binding protein EcfA2 + Type VI secretion system peptidoglycan-associated domain + Protein of unknown function DUF1488 + Mobile mystery protein A + Protein of unknown function DUF3144 + Transcription antitermination protein RfaH + RNA polymerase archaeal subunit P/eukaryotic subunit RPABC4 + Protein of unknown function DUF3622 + Peptidase M17, peptidase B + L-lactate dehydrogenase + D-xylose ABC transporter, substrate-binding protein + Rhamnose ABC transporter, substrate-binding protein RhaS + LacY/RafB permease family + AMP phosphorylase + Ribulose bisphosphate carboxylase, type III + Der GTPase activator + Manganese catalase + Peptidase M3B, oligoendopeptidase-related + Surface carbohydrate biosynthesis protein + Protein of unknown function DUF3761 + Formate transporter FocA, putative + Putative phage abortive infection protein + N-carbamoylputrescine amidase + Conserved hypothetical protein CHP02588 + Omega-3 polyunsaturated fatty acid synthase-like + Uncharacterised protein family, basic secretory protein + Alpha-N-acetylglucosaminidase, C-terminal + LydA-like holin + Protein of unknown function DUF2199 + Bacteriophage T4, Gp32, single-stranded DNA-binding + Conserved hypothetical protein CHP02117 + GAD-related + P-type ATPase, subfamily IIIA + Archaeal dihydromethanopterin reductase + Progressive ankylosis + Zinc-ribbon domain, bacteria + PD-(D/E)XK nuclease + 4-carboxymuconolactone decarboxylase + Ribonuclease M5, C-terminal domain + Sporulation stage III, transcriptional regulator SpoIIID + Cytochrome o ubiquinol oxidase, subunit III + Protein of unknown function DUF3482 + Tyrosinase copper-binding domain + L-alanine exporter AlaE + ATP-dependent DNA ligase, PP_1105 family + Domain of unknown function DUF4377 + Streptothricin acetyltransferase + Protein of unknown function DUF4260 + YaiO family, OMP domain + Uncharacterised conserved protein UCP037052 + NUDIX hydrolase, NudL, conserved site + Protein of unknown function DUF4857 + Siphovirus Gp157 + Domain of unknown function DUF835 + Photosystem antenna protein-like + Domain of unknown function DUF4842 + Polycystic kidney disease type 2 protein + Oxygen oxidoreductase covalent FAD-binding site + Fis1, C-terminal tetratricopeptide repeat + Tryptophan/tryrosine permease, conserved site + Glutamate mutase sigma subunit + Flavodoxin, short chain + ADP-specific phosphofructokinase/glucokinase + Peptidase M9A/M9B, collagenase, bacterial + Aspartyl-phosphate phosphatase Spo0E-like + Tetratricopeptide TPR-3 + Protein of unknown function DUF2516 + Extracellular protein + Nitrite reductase, copper-type + Malate synthase A + Uncharacterised protein family YfdX + Methionine repressor MetJ + Protein of unknown function DUF4152 + ATP-dependent DNA helicase PcrA + Bacteriophage T4, Gp14, neck protein + Integrating conjugative element protein, PFL4669 + C-terminal AAA-associated domain + D-lactate dehydrogenase, membrane binding, C-terminal + Anti-sigma factor RsgI, N-terminal + Conserved hypothetical CHP02185, integral membrane + Aminoglycoside-2''-adenylyltransferase + Protein of unknown function DUF4760 + M60-like domain, N-terminal + Pseudaminic acid biosynthesis-associated methyltransferase + 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase + Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase + Citrate lyase ligase, C-terminal + AT hook, DNA-binding motif + Protein of unknown function DUF366 + Aminoglycoside/hydroxyurea antibiotic resistance kinase + Cholinesterase + Fn3-like domain + Pyrrolysine biosynthesis protein PylB + Fibrillarin, conserved site + Major royal jelly protein/protein yellow + Domain of unknown function DUF4457 + ParB-like nuclease, C-terminal domain + Bacteriophage tail completion protein R + Lysine methyltransferase + Hexokinase, C-terminal + Putative sugar O-methyltransferase + Conserved hypothetical protein CHP02301 + Phage baseplate assembly protein V/Gp45 + Methyltransferase Mtx, subunit X + Cysteine protease Prp + DNA primase DnaG, C-terminal helicase-binding domain + Domain of unknown function DUF155 + Benzoyl-CoA reductase, bzd-type, Q subunit + Aromatic acid exporter family member 1 + Cwf19-like, C-terminal domain-1 + [FeFe]-hydrogenase H-cluster maturation GTPase HydF + Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase + YadA-like, C-terminal + Protein of unknown function DUF2299 + Protein of unknown function DUF2960 + Malate dehydrogenase enzyme, N-terminal + Mitochondrial PGP phosphatase + Protein of unknown function DUF2612 + Pentraxin-related + CRISPR-associated protein, TM1793 + Glycosyl hydrolase family 115 + Ribosomal protein L19/L19e conserved site + Glucodextranase, N-terminal + Pyridoxine kinase + Indoleamine 2,3-dioxygenase + Uncharacterised protein family YfcL + Glycosyltransferase AglJ + Hydrophobe/amphiphile efflux-3 HAE3 + Legume lectin domain + Flagellar, putative + Protein DcrB + Putative methanogenesis marker protein 10 + Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase, thiamine diphosphate binding site + Protein of unknown function DUF417 + Domain of unknown function DUF1794 + ENTH/VHS + Haemin-degrading HemS/ChuX domain + Transposon Tn7 transposition protein TnsD, C-termianl + Domain of unknown function DUF4168 + Protein of unknown function DUF3089 + Molybdopterin guanine dinucleotide-containing S/N-oxide reductase + Phosphoadenosine phosphosulphate reductase CysH + Phenylacetate-CoA ligase + Uncharacterised conserved protein UCP022079 + [FeFe]-hydrogenase maturation HydE, radical SAM + Abortive phage resistance protein AbiGi + Regulator of RNA terminal phosphate cyclase + Protein of unknown function DUF2987 + Protein of unknown function DUF3383 + Arsenite oxidase, small subunit + RNA polymerase sigma-70 ECF-like, Rhodopirellula baltica + Protein of unknown function DUF2336 + Bax inhibitor 1, conserved site + Methanol-cobalamin methyltransferase, B subunit + Acyltransferase, WS/DGAT/MGAT + RNA polymerase sigma-X type + Alpha/beta-hydrolase, N-terminal domain + Protein kinase A anchor protein, nuclear localisation signal domain + Putative multidrug resistance efflux transporter + Coronovirus spike glycoprotein, heptad repeat 2 domain + HmuY protein + Pyruvate formate-lyase activating enzyme + Protein of unknown function DUF3501 + Snf7 family + Alpha/beta-hydrolase, catalytic domain + Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase, putative + DNA ligase D, ligase domain + Protein of unknown function DUF1496 + Protein of unknown function DUF2103, metal-binding + Replication-associated protein G2P, C-terminal + Flagellar transcriptional activator FlhC + Uncharacterised protein family A0KLC6 + Protein of unknown function DUF3141 + Protein of unknown function DUF3626 + Kanamycin nucleotidyltransferase, C-terminal + Putative selenate reductase YgfK + Putative nitrogen fixation protein + Thg1 C-terminal domain + Fas apoptotic inhibitory molecule 1 + Uncharacterised protein family YnzE + NLPC/P60, N-terminal domain + Uncharacterised conserved protein UCP008210 + Replication factor A, C-terminal + Domain of unknown function DUF4965 + Chloramphenicol phosphotransferase-like + Protein of unknown function DUF3574 + dsDNA mimic, putative + Bacteriophage 186, CII + Protein of unknown function DUF1641 + Acireductone dioxygenase ARD family + [FeFe]-hydrogenase system regulator TM1266 + Chorismate mutase, gammaproteobacteria + Protein of unknown function DUF992 + Uncharacterised protein family UPF0325 + Protein of unknown function DUF1428 + Nitrogenase molybdenum-iron protein beta chain + Nitrogenase molybdenum-iron protein alpha chain + Acidobacterial duplicated orphan permease + Cobalamin (vitamin B12) biosynthesis CobF, precorrin-6A synthase + Protein of unknown function DUF2855 + Variant SH3 domain + Protein of unknown function DUF4269 + Uridine phosphorylase + 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase + Small acid-soluble spore protein, alpha/beta-type, conserved site + Vacuolar fusion protein Mon1 + Glycosyl hydrolases 36 + Malate synthase, conserved site + T4 endonuclease V + Phytochrome + rRNA methyltransferase AviRa + PA2201-like, C-terminal + Flagellar filament outer layer protein FlaA + Transferrin-binding protein, C-lobe/N-lobe beta barrel domain + Beta/gamma crystallin + tRNA(Met) cytidine acetyltransferase TmcA, tRNA-binding domain + C2 domain + G8 domain + Bacteriophage T4, Gp59, helicase assembly protein, N-terminal + Conserved hypothetical protein CHP03503 + Domain of unknown function DUF892 + Uncharacterised protein family HutD/Ves + Domain of unknown function DUF4990 + Domain of unknown function DUF4476 + Sulphite reductase (NADPH) hemoprotein, beta subunit + D-serine ammonia-lyase + Protein of unknown function DUF473 + 2,3-diaminopropionate biosynthesis protein SbnA + Ribosomal S4P (gammaproteobacterial) + Bacteriophage Mu, Gp27 + Protein of unknown function DUF2127 + Archaeal flagella protein FlaD/E domain + Ribosomal protein L40e + Uncharacterised conserved protein UCP014543 + Sugar transport protein + Cationic amino acid transporter, C-terminal + Alpha-ribazole phosphatase, CobZ + Ribosomal protein L22e + Uncharacterised protein family UPF0324, bacteria + Nif11 domain + Fumarate reductase, subunit C + 6-oxocyclohex-1-ene-1-carbonyl-CoA hydrolase + Sulphite reductase [NADPH] flavoprotein, alpha chain + Uncharacterised conserved protein UCP019164, methanogenesis + Orn/Lys/Arg decarboxylase, N-terminal + Protein of unknown function DUF1840 + Domain of unknown function DUF1851 + Domain of unknown function DUF4189 + Blue (type 1) copper protein, plastocyanin-type + Oligosaccharyl transferase complex, subunit OST3/OST6 + Phage protein (N4 Gp49/phage Sf6 gene 66) family + Phenol hydroxylase subunit + Benzoyl-CoA-dihydrodiol lyase + Benzoyl-CoA oxygenase/reductase, BoxA protein + Benzoyl-CoA oxygenase, B subunit + Ribosomal protein S30 + Protein of unknown function DUF899, thioredoxin-like + Domain of unknown function DUF4833 + Cyclic peptide transporter + Mini-chromosome maintenance complex protein 4 + Chitinase A N-terminal + Calcium/calmodulin-dependent protein kinase II, association-domain + Proteinase inhibitor I13, potato inhibitor I + Urea carboxylase-associated protein 2 + ATPase, secretion system, PEP-CTERM, predicted + Phage protein of unkonwn function + Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase, C-terminal + MbtH-like protein + Ethanolamine permease + Domain of unknown function DUF4261 + Domain of unknown function DUF4178 + Protein of unknown function DUF3084 + Domain of unknown function DUF1713 + L-lysine 6-transaminase + HNS-dependent expression A/B + Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase, conserved site + CRISPR-associated endonuclease Cas9, REC lobe + Mitochondrial carrier domain + Protein of unknown function DUF1571 + Bacteriophage T4, Gp59, helicase assembly protein, C-terminal + Phosphotransferase system, enzyme II sorbitol-specific factor + Domain of unknown function DUF3870 + Type VI secretion system (T6SS), amidase effector protein 4 + AmiS/UreI transporter + Conjugative transposon, TraO + Protein of unknown function DUF2860 + Protein of unknown function DUF3103 + Bacteriocin-type signal sequence + Putative methanogenesis marker domain 9 + Antitoxin VapB-like + RNA polymerase sigma-B/F/G type + Integrin beta subunit, VWA domain + TRSP domain + Protein of unknown function DUF2098 + Glutathione reductase, eukaryote/bacterial + Protein of unknown function DUF3955 + Protein of unknown function DUF2974 + Creatinine amidohydrolase + DNA phosphorothioation-dependent restriction protein DptG + Bacteriophage P2, GpM + Translation elongation factor P-like, YeiP + Bacteriophage HP1, Orf28 + Bacteriophage HP1, Orf23 + Protein of unknown function DUF2569 + Anti-sigma-F factor NrsF + Protein of unknown function DUF2568 + DNA-directed RNA polymerase, helix hairpin domain + H/ACA ribonucleoprotein complex, subunit Nop10 + Transcription regulator HTH, APSES-type DNA-binding domain + KaiB domain + Protein of unknown function DUF2194 + Integrating conjugative element protein, PFL4697-type + Zinc finger-XS domain + Protein of unknown function DUF378 + Phage portal protein PBSX family + Bacteriophage Mu, Gp46 + Transcription regulator PrtN + Phasin, subfamily 3 + Putative formate dehydrogenase, TAT signal-containing + Putative transmembrane family 234 + Protein of unknown function DUF2850 + Hypothetical protein TM1646-like domain + Peptidase M9, collagenase, N-terminal domain + MatP, C-terminal ribbon-helix-helix domain + Conserved hypothetical protein CHP03083, actinobacterial-type + Fumarate reductase, subunit D + Protein of unknown function DUF3083 + Protein of unknown function DUF997 + Cytochrome b561/ferric reductase transmembrane + Domain of unknown function DUF2023 + Protein of unknown function DUF3618 + Protein of unknown function DUF2026 + Protein of unknown function DUF2600 + Domain of unknown function DUF3991 + Rhamnose isomerase-related + Domain of unknown function DUF4375 + Methylthioribulose-1-phosphate dehydratase + LuxT regulator, helix hairpin domain + MIT + Type IV secretion system protein VirB11 + Domain of unknown function DUF4959 + Integrating conjugative element protein, PFL4704 + Cellulose synthase operon C, C-terminal + TRASH transcription regulator C-terminal, archaeal + Ribonucleotide reductase alpha chain + RNA polymerase sigma-Z type + Protein of unknown function DUF2607 + Insecticide toxin TcdB middle/C-terminal + Homotrimeric ring hydroxylase, catalytic domain + Metallothionein, family 14, prokaryote + Putative 1-pyrroline-5-carboxylate dehydrogenase, Bacillales + Ribosomal protein L39e, conserved site + Immunoglobulin-like domain + Uncharacterised protein family UPF0212 + Proteasomal ATPase, OB/ID domain + Endo-1,3(4)-beta-glucanase + Type-F conjugative transfer system mating-pair stabilisation protein TraN + Protein of unknown function DUF4144 + Protein of unknown function DUF1634 + Type II restriction enzyme NlaIII/ICEA1 + Tail accessory factor GP4 + Malate dehydrogenase, type 1 + HAD-superfamily hydrolase, subfamily IA, CTE7 + Lipase chaperone + L-methionine gamma-lyase + Domain of unknown function DUF1937 + Protein of unknown function DUF3011 + Domain of unknown function DUF4132 + Uncharacterised protein family, YqcI/YcgG + Protein of unknown function DUF535 + Protochlamydia outer membrane protein + Domain of unknown function DUF4980 + Fructose-bisphosphate aldolase class-I active site + Hemocyanin/hexamerin + Lacto-N-biose phosphorylase, central domain + Integral membrane protein TerC, riboswitch-linked + Domain of unknown function (DUF4240 + Porin, gammaproteobacterial + Ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent + Replication-associated protein G2P + FecR, N-terminal + Plasmid replicase, bacterial + C(7)-type cytochrome triheme domain + Phosphonopyruvate decarboxylase + Putative ABC exporter + Protein of unknown function DUF5005 + Protein of unknown function DUF4364 + Laminin IV + Protein of unknown function DUF1145 + Mutator MutX protein + Protein of unknown function DUF4868 + Glutamate--cysteine ligase GshA + Membrane-bound tetrahaem cytochrome TorC/YecK + CagE, TrbE, VirB component of type IV transporter system + Leucine rich repeat variant + CAT RNA-binding domain + Dimethlysulfonioproprionate lyase DddL + Extracellular lipase, Pla-1/cef family + Lanthionine synthetase C-like + Bacteriophage abortive infection AbiH + Helicase SMUBP-2/Hcs1-like + Protein of unknown function DUF4164 + 2-dehydro-3-deoxy-phosphogluconate aldolase + CspD, cold shock + NlpE, C-terminal OB domain + Protein of unknown function DUF1391 + DNA circulation, N-terminal + Peptidase M11, gametolysin + SseB protein, C-terminal + Glycosyl transferase family 29 + Pectinesterase, Asp active site + Protein of unknown function DUF3440 + Bacteriophage TLS, TfmB + Ribosomal protein L15e, conserved site + Zinc finger, LSD1-type + XPA C- terminal + Protein of unknown function DUF4330 + Glycoside hydrolase, family 52 + Virulence factor membrane-bound polymerase, C-terminal + Protein of unknown function DUF1240 + Type III secretion system outer membrane pore YscC/HrcC + NADH:ubiquinone/plastoquinone oxidoreductase, chloroplast chain 5, C-terminal + Quinohemoprotein amine dehydrogenase, alpha subunit, domain 2 + Sortase, proteobacterial type + Cofactor-binding repeat, putative + Chorismate mutase, periplasmic + Mitochondrial apoptosis-inducing factor, C-terminal domain + Class III signal peptide motif + Phage-integrase repeat unit + Domain of unknown function DUF5017 + Protein of unknown function DUF2934 + Protein of unknown function DUF2931 + Dihydroorotase-like, bacterial + N-acetylmuramidase + Bacteriophage lambda, GpL, minor tail + High-affinity branched-chain amino acid transport system permease, LivHM, N-terminal + Protein of unknown function DUF1796 + Ribose-5-phosphate isomerase, C-terminal + Beta-glucanase + Iodothyronine deiodinase + 5-histidylcysteine sulfoxide synthase + Pyrrolysyl-tRNA ligase, N-terminal + Protein of unknown function DUF1361 + Conserved hypothetical protein CHP00061 + Formate dehydrogenase, transmembrane + Mycobacterium phage PG1, Gp7 + Domain of unknown function DUF2294 + DNA mismatch repair protein MutH + Methyl coenzyme M reductase, alpha subunit + Protein of unknown function DUF1097 + Protein of unknown function DUF483 + Tartrate dehydrogenase + Pab87 octamerisation domain + 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase + Small acid-soluble spore protein, alpha/beta-type + CRISPR locus-related putative DNA-binding protein Csa3 + Bacillithiol biosynthesis thiol disulphide oxidoreductase, YpdA + Mu-type HTH domain + 3-dehydroquinate dehydratase, active site + Cytochrome b5, heme-binding site + Ubiquitin-related modifier 1 + Squalene synthase HpnC + Copper type II, ascorbate-dependent monooxygenase, N-terminal + Domain of unknown function DUF2846 + Protein of unknown function DUF2829 + Ribonucleotide reductase N-terminal + CRISPR-associated DxTHG protein + Ribulose bisphosphate carboxylase small chain, domain + PIN-domain ribonuclease + Inositol oxygenase + Maltose operon periplasmic + Bacteriophage lambda, GpM, minor tail + Transcriptional regulator + GINS subunit, domain A + Epoxide hydrolase, N-terminal + Conserved hypothetical protein CHP04442 + TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase + Protein of unknown function DUF1919 + Protein of unknown function DUF1917 + Protein of unknown function DUF4250 + Porin PorA + Protein of unknown function DUF3293 + Copper-resistance protein CopA + Protein of unknown function DUF1579 + Atu2299-like domain + Uncharacterised protein family UPF0146 + Phage phiEco32-like COOH-NH2 ligase-type 2 + Alcohol acetyltransferase/N-acetyltransferase + Glycoside hydrolase family 9, His active site + Killing trait, RebB + Uncharacterised protein family UPF0473 + Conserved hypothetical protein CHP04083, radical SAM + Succinate CoA transferase + N-alpha-acetyl diaminobutyrate deacetylase DoeB + Ectoine utilization protein EutD + Protein of unknown function DUF4434 + Bacteriophage rv5, Orf52 + Protein of unknown function DUF1449 + TnsA endonuclease C-terminal + Dinitrogenase reductase ADP-ribosyltransferase + Translation repressor RegA + 2-oxoisovalerate dehydrogenase, E1 alpha subunit, N-terminal domain + Purine nucleoside permease + Protein of unknown function DUF3793 + Ribonucleoside-triphosphate reductase activating, anaerobic + Protein of unknown function DUF977 + Chlorophyll a/b binding protein domain + Protein of unknown function DUF3634 + Phosphoheptose isomerase + G-protein, beta subunit + Tyrosine phenol-lyase + Dihydroorotate dehydrogenase A, chain A, domain 2 + Putative ccm operon protein + FCP1 homology domain + Mitochondrial inner membrane protein Mitofilin + Ribosomal RNA small subunit methyltransferase F, first C-terminal domain + Thiosulphate:quinone oxidoreductase small subunit DoxA + Sorbitol phosphotransferase enzyme II, C-terminal + Cyanophycin synthetase + Bacteriophage HP1, Orf24 + Protein of unknown function DUF3311 + Alternate ATP synthase, F1 complex, subunit gamma + 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain + Gamma-aminobutyric acid A receptor/Glycine receptor alpha + Protein of unknown function DUF5058 + Capsid scaffolding protein GpO + Staphylococcal AgrD + Protein of unknown function DUF2071 + 30S ribosomal protein + Protein of unknown function DUF4156 + D-lactate dehydrogenase, C-terminal subdomain 2 + Domain of unknown function DUF4401 + Alpha galactosidase A, C-terminal beta-sandwich domain + HprK-related kinase A + Enterobacterial TraT complement resistance + Bacteriophage P2, GpN, major capsid + Protein of unknown function DUF3326 + Carotenoid oxygenase + Ferredoxin III 4[4Fe-4S], nif-specific + Ribosomal protein S3Ae, conserved site + Domain of unknown function DUF1540 + Protein of unknown function DUF736 + Glutamine synthetase, type III + Non-histone chromosomal MC1 + TROVE domain + Alpha-2-macroglobulin, conserved site + Protein of unknown function DUF1266 + Translation initiation factor, beta propellor-like domain + MEKHLA + RNA polymerase sigma-H type + Protein of unknown function DUF3303 + Domain of unknown function DUF4180 + Domain of unknown function DUF4179 + Streptococcus phage 7201, Orf34, N-terminal + O-succinylhomoserine (thiol)-lyase + Capsule biosynthesis phosphatase + Nitrogenase molybdenum-iron cofactor biosynthesis protein + Peroxiredoxin-like FAM213/AAED1 + Choice-of-anchor B domain + Superinfection exclusion protein B + Metallo-carboxypeptidase, C-terminal domain + Protein of unknown function DUF4272 + Putative CRISPR-associated protein, VVA1548 family + Mpv17/PMP22 + Periplasmic nitrate reductase, large subunit + MucBP domain + Conserved hypothetical protein CHP03858, luciferase-like monooxygenase, putative + Conserved hypothetical protein CHP03843 + Basic-leucine zipper domain + Tubulin + Nodulation protein Z + Domain of unknown function DUF2431 + Pyruvate dehydrogenase E1 component subunit alpha/BCKADH E1-alpha + Uncharacterised conserved protein UCP019262 + B-block binding subunit of TFIIIC + Photosystem II PsbK + ATP:guanido phosphotransferase, N-terminal + Prion/Doppel protein, beta-ribbon domain + Haem oxygenase-like + Squalene cyclase + Competence protein ComK + TerY-C metal binding domain + Protein of unknown function DUF2441 + Uncharacterised protein family UPF0285, methanogenesis + Conserved hypothetical protein CHP03979 + Putative Flagellin, Flp1-like domain + Putative DNA-binding protein, HU-related + Protein of unknown function DUF4127 + LDLR class B repeat + Diaminopropionate ammonia-lyase, subgroup + Ribosomal protein L37e + Phenol hydroxylase + Bacteriophage CI repressor, C-terminal + Putative NADH-ubiquinone oxidoreductase chain E + Mycolic acid cyclopropane synthase-like domain + Primosomal replication protein PriB + Protein of unknown function DUF1207 + SynChlorMet cassette radical SAM/SPASM protein ScmF + Protein of unknown function DUF2913 + Conserved hypothetical protein CHP02421, QEGLA + Protein of unknown function DUF3861 + 6-phosphofructo-2-kinase + Caa(3)-type oxidase, subunit IV + Protein of unknown function DUF2500 + Proteasome activator pa28, C-terminal domain + Protein of unknown function DUF2274 + Solitary outer membrane autotransporter beta-barrel domain + Protein of unknown function DUF2945 + Transcription factor TFE, archaea + Cyanuric acid hydrolase/Barbiturase + Protein of unknown function DUF979 + Protein of unknown function DUF3658 + YlqD protein + DKNYY family + Uncharacterised protein family MJ1658 + Protein of unknown function DUF969 + Glycosyl transferase, family 31 + Polyketide-type polyunsaturated fatty acid synthase, PfaA + Peptidase, metallopeptidase M10/M27/M57 + FAD-containing D-sorbitol dehydrogenase small subunit + Phox homologous domain + Phage tail assembly chaperone protein + Peptidase C19, ubiquitin carboxyl-terminal hydrolase + Uncharacterised protein family UPF0297 + RNA polymerase Rpb1, domain 7 + Protein glycosylation ligase domain + Protein of unknown function DUF3540 + Acetyl-CoA C-acyltransferase FadI + UrcA family protein + Protein of unknown function DUF4831 + Cytochrome f + 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase, type 2 + Protein of unknown function DUF5049 + Protein of unknown function DUF1934 + Phenol hydroxylase, C-terminal dimerisation domain + Protein Him1/Fmp52 + Cytochrome P450, E-class, group IV + Conserved hypothetical domain CHP03000, planctomycetes + UDP-glycosyltransferase, MGT + RNA-dependent RNA polymerase, eukaryotic-type + Membrane attack complex component/perforin (MACPF) domain + Domain of unknown function DUF1911 + Acyl homoserine lactone synthase + Expansin, cellulose-binding-like domain + Protein of unknown function DUF3039 + Restriction endonuclease, type II, BstXI + Paraneoplastic encephalomyelitis antigen + Lipocalin + Glutathione synthase + Zinc-binding loop region of homing endonuclease + Bacterial toxin 44 + Proteobacterial sortase system peptidoglycan-associated protein + Histidine acid phosphatase active site + Domain of unknown function DUF2135 + Glycine-zipper-containing OmpA-like membrane domain + Glycosyltransferase GT-D fold + C4-dicarboxylate anaerobic carrier + RNA polymerase sigma-I type + Nuclear transport factor 2 + Homocitrate synthase, fungi/archaea + Radical SAM peptide maturase, GG-Bacteroidales family + Protein of unknown function DUF3157 + PilX/PilW C-terminal domain + ABC transporter, urea utilisation-associated, substrate-binding protein + ATPase, type I secretion system, HlyB + Putative methanogenesis marker protein 11 + EAP30 + Thiopeptide-type bacteriocin biosynthesis domain + RNA polymerase sigma-70 factor, Planctomycetaceae + Flagellar FliJ, proteobacteria + Terpene synthase, conserved site + Quinohemoprotein amine dehydrogenase, alpha subunit domain IV + S-layer protein + Glycine oxidase ThiO + ERV/ALR sulfhydryl oxidase domain + Restriction endonuclease, type II, ScaI + Barrier- to-autointegration factor, BAF + Uncharacterised conserved protein UCP037205 + Trans-membrane regulatory protein ToxS + Toxin co-regulated pilus biosynthesis protein Q, C-terminal + Protein of unknown function DUF2778 + Uncharacterised conserved protein UCP028299 + E3 UFM1-protein ligase 1 + Protein of unknown function DUF2785 + His-Xaa-Ser system radical SAM maturase HxsB + Hopanoid biosynthesis associated radical SAM protein HpnH + Protein of unknown function DUF1040 + Antirepressor protein, C-terminal + Amicyanin/Pseudoazurin + Protein of unknown function DUF1906 + Integrating conjugative element protein PilL, PFGI-1 + Cellulose synthase + Domain of unknown function DUF2272 + CRISPR-associated protein, GSU0054 + Glycosyltransferase, GlcNAc + 2-methylcitrate dehydratase PrpD + Pyrimidine 5'-nucleotidase, eukaryotic + Nitrogen fixation protein NifM + Conserved hypothetical protein CHP02808 + Heavy metal sensor kinase + Transcriptional regulatory protein PcoR, heavy metal response + Protein of unknown function DUF3798 + YcnI-like + Campylobacter major outer membrane + Protein of unknown function DUF3150 + ParB-related, ThiF-related cassette, ThiF + Protein of unknown function DUF4783 + Rhomboid protease, N-terminal + Stealth protein CR3, conserved region 3 + Choice-of-anchor A domain + Zinc finger, CGNR + PcfJ-like protein + Protein of unknown function DUF3997 + Potassium channel, inwardly rectifying, Kir + Protein kinase G, tetratricopeptide repeat containing domain + Protocatechuate 4,5-dioxygenase, alpha subunit + Lysine-specific metallo-endopeptidase + Protein of unknown function DUF3541 + Fatty oxidation complex, alpha subunit FadJ + FAE1/Type III polyketide synthase-like protein + Mu DNA binding, I gamma subdomain + Protein of unknown function DUF3750 + Putative addiction module antidote + Phosphoenolpyruvate carboxylase, archaeal-type + 30S ribosomal protein Thx + Inositol monophosphatase, Lithium-sensitive + Nitrogen fixation negative regulator NifL + Glycoside hydrolase, family 85 + Type-F conjugative transfer system pilin assembly protein TrbC + Mercuric transport protein MerT + Luciferase-type oxidoreductase + Suppressor of fused-like domain + Protein of unknown function DUF1598 + Transposase, Tc1-like + ATP-grasp family + Ferric iron reductase, C-terminal + Seed maturation protein + 3(2),5 -bisphosphate nucleotidase HAL2 + Restriction endonuclease, type II, BglI + Protein of unknown function DUF2203 + Bacteriophage Mu, Gp25 + Ubiquitin + Acyl-CoA ligase (AMP-forming), exosortase system type 1 associated + Phosphogluconate dehydrogenase (decarboxylating) , C-terminal + LamB-type porin N-terminal domain + Protein of unknown function DUF1256 + Transmembrane protein 43 family + Pantothenate kinase + Laminin G domain + Ribonuclease HIII, N-terminal + Phage major tail protein, phi13 family + Cytochrome o ubiquinol oxidase, subunit I + Exosome complex component CSL4 + Pancreatic trypsin inhibitor Kunitz domain + Uncharacterised protein family UPF0478 + [FeFe] hydrogenase, group B1/B3 + Putative heme utilization radical SAM enzyme HutW + Tetracycline transcriptional regulator, TetR, C-terminal + Ribosomal protein L13e + Protein of unknown function DUF4262 + Pas factor saposin domain + Ribonucleoside reductase subunit beta, NrdF + Actin/actin-like conserved site + Integral membrane protein, YccS/YhfK + Protein of unknown function DUF896 + Minor capsid protein + Helix-turn-helix, conjugative transposon-like + Putative OmpA-OmpF-like porin family + Protein of unknown function DUF4839 + Domain of unknown function DUF5000 + Domain of unknown function DUF4116 + Cyclic di-GMP receptor, atypical PilZ domain + Protein of unknown function DUF1405 + Domain of unknown function DUF4453 + Bacteriophage lambda, GpH, tail tape measure, N-terminal + ESCRT-II complex, vps25 subunit + Cupin fold metalloprotein, WbuC family + Ubiquitin-activating enzyme E1, FCCH domain + DNA helicase, ATP-dependent, UvrD type + Protein of unknown function DUF3262 + AMP nucleosidase, putative + Peptidase M42, hydrolase + Diol dehydratase reactivase ATPase-like domain + Limonene-1,2-epoxide hydrolase + Leukocidin/porin + Novel toxin 16 + Mycoplasma virulence, signal domain + Phosphonatase-like hydrolase + Domain of unknown function DUF1735 + Integral membrane protein, YccS + Heme utilization carrier protein HutX-like + Protein of unknown function DUF4450 + Phosphotransferase system, N-acetylglucosamine-specific IIBC component + Carboxynorspermidine decarboxylase + Ribonuclease M5 + Integrating conjugative element protein, PFL4695 + IolE/MocC family + Quinoprotein relay system zinc metallohydrolase 2 + Macrophage migration inhibitory factor + Protein of unknown function DUF2214, membrane + Domain of unknown function DUF2399 + Photosystem II PsbY + HAD-superfamily hydrolase, LHPP/HDHD2 + Conserved hypothetical protein CHP00288 + Bacterial OB-fold + Peptidase G2, IMC autoproteolytic cleavage domain + Quinoprotein dehydrogenase-associated + Putative metal-binding protein + Ribosomal protein L18e, conserved site + Peptidase M8, leishmanolysin + Hexokinase, N-terminal + Bacterial purine repressor, N-terminal + Phage tail assembly chaperone TAC_10 + Potassium channel, inwardly rectifying, Kir, cytoplasmic + Bacteriophage lambda, GpS, holin + Protein of unknown function DUF2452 + Protein of unknown function DUF903 + Insecticidal toxin complex/plasmid virulence protein + Ribonuclease II + Carbohydrate binding X2 domain + Transglutaminase elicitor + Putative 5-3 exonuclease + Glycoside hydrolase, family 16, active site + HEAT repeat associated with sister chromatid cohesion protein + Benzoyl-CoA reductase, bzd-type, N subunit + Cyclohexa-1,5-dienecarbonyl-CoA hydratase + Zinc finger, double-stranded RNA binding + Uncharacterised protein family MTH865 + F420-binding domain, putative + Translational regulator Com + Protein of unknown function DUF2292 + Protein of unknown function DUF2290 + SH3b2-type SH3 domain + Endosialidase, N-terminal extension domain + SUN domain + Armadillo + Protein of unknown function DUF3872 + Condensin complex subunit 1, C-terminal + Protein of unknown function DUF3404 + Recombination, repair and ssDNA binding protein UvsY + Aspartate ammonia-lyase + ATP synthase YMF19-like, N-terminal + Zinicin-like metallopeptidase type 2 + TFIIH subunit TTDA/Tfb5 + Pyridoxamine 5'-phosphate oxidase, Alr4036 family, FMN-binding domain + Non-structural maintenance of chromosome element 4, C-terminal + Ragulator complex protein LAMTOR3 + Protein of unknown function DUF3703 + Sterile alpha motif domain + Helical bimodular sensor domain + Nitrate transport permease + Protein of unknown function DUF2018 + Conserved hypothetical protein CHP03808 + Protein of unknown function DUF2343 + 2-keto-3-deoxygluconate permease + Gp45 sliding clamp, C-terminal + Transcription regulator MAATS, C-terminal + Ataxin, AXH domain + Zinc finger, BED-type + Protein of unknown function DUF1407 + CD225/Dispanin family + Glycosyltransferase domain + YfaZ + Protein of unknown function DUF3025 + 3-alpha domain + Geranylgeranylglyceryl phosphate synthase, archaea + N-acetyltransferase ESCO, zinc-finger + Squalene epoxidase + HP0242-like domain + Phenylphosphate carboxylase, gamma subunit + GOLD domain + Uncharacterised domain, di-copper centre + Bacteriophage T7 tail fibre protein + Glycerol-3-phosphate cytidylyltransferase + P-type ATPase, subfamily IIB + Phenylacetate-CoA oxygenase/reductase, PaaK subunit + Peptidase M36, fungalysin + Lycopene cyclase, beta/epsilon + Bacterial toxin homologue of phage lysozyme, C-terminal + Thymidylate synthase, archaea + Protein of unknown function DUF4493 + Protein of unknown function DUF4494 + Spore germination YpeB + Sporulation protein YlmC/YmxH + CRISPR-associated protein Csy1 + Beta-lysine N-acetyltransferase + Chitinase, C-terminal + Phenylphosphate carboxylase, beta subunit + Bacteriophage phi-Lf, Orf112 + Protective antigen, heptamerisation domain + Hypothetical glycoside hydrolase 5 + Anthranilate synthase component I, TrpE-like, bacterial + GNAT N-acetyltransferase, putative + Uncharacterised conserved protein UCP006685 + CRISPR-associated protein DxTHG, conserved site + Protease inhibitor I35 (TIMP) + Homeobox protein, antennapedia type, conserved site + 3-hexulose-6-phosphate synthase + Patatin-related protein + Vacuolar protein sorting-associated, VPS28 + Domain of unknown function DUF550 + Protein of unknown function DUF1877 + DNA ligase D + Leucine-rich glioma-inactivated , EPTP repeat + Domain of unknown function DUF4149 + Domain of unknown function DUF4918 + Domain of unknown function DUF2479 + Protein of unknown function DUF2845 + Protein of unknown function DUF3194 + Glycosyl hydrolases family 9, Asp/Glu active sites + ABC transport system, 1-aminoethylphosphonate-binding protein, putative + Protein of unknown function DUF2227, metal-binding + Restriction system-associated AAA family ATPase + Neurotransmitter-gated ion-channel transmembrane domain + Citrate lyase ligase + Bacteriophage head completion protein GpL + Protein of unknown function DUF4907 + 2-oxo-hepta-4-ene-1,7-dioic acid hydratase + Lycopene cyclase + Uncharacterised protein family, RAQPRD + D-lactate dehydrogenase, C-terminal subdomain 1 + PQQ-dependent membrane bound dehydrogenase + DNA photolyase class 2, conserved site + DUF3686 + Putative 7-carboxy-7-deazaguanine synthase QueE, Proteobacteria + Phosphatase PHOSPHO-type + Inositol-tetrakisphosphate 1-kinase + Uncharacterised conserved protein UCP017998 + Protein of unknown function DUF3612 + Peptidase A22A, presenilin + Protein of unknown function DUF3325 + Protein of unknown function DUF4006 + Protein of unknown function DUF4003 + Protein of unknown function DUF3999 + Twin-arginine translocation signal, Cys-rich four helix bundle protein + Protein of unknown function DUF5076 + Cupin 1 + Bacteriophage holin HP1 family + Ferredoxin-dependent bilin reductase + Uncharacterised protein MJ0570 + Replicative helicase inhibitor G39P, N-terminal + Capsular polysaccharide synthesis + Protein of unknown function DUF4304 + Hexon coat protein, subdomain 4 + Pyridoxal-dependent decarboxylase, exosortase system type 1 associated + Domain of unknown function DUF4424 + Subtilase, N-terminal + Bacteriophage P22 tailspike, N-terminal + Beta-lactamase-inhibitor protein BLIP + Protein of unknown function DUF1176 + Protein of unknown function DUF1651 + Carbohydrate binding module family 20 + FAD-dependent oxidoreductase, HpnW + Chorismate mutase, archaeal + 2-succinylbenzoate--CoA ligase + YcbB domain + Endoglucanase Z, cellulose-binding domain + P-type ATPase, subfamily IIA, SERCA-type + Domain of unknown function DUF2185 + Legume lectin, beta chain, Mn/Ca-binding site + LGFP + Domain of unknown function DUF5109 + Succinylglutamate desuccinylase + Isopropylmalate/isohomocitrate dehydrogenase + Surface antigen domain + ThiJ/PfpI family-like + Enolase-phosphatase E1 + Phosphoribosyl transferase + Nitrogenase MoFe cofactor biosynthesis protein NifE + Protein of unknown function DUF4358 + Cobalamin (vitamin B12) biosynthesis CobG-like + ZU5 domain + Flavin amine oxidase + Protein of unknown function DUF1090 + Specific amino acids and opine-binding periplasmic protein, ABC transporter + Protein of unknown function DUF4747 + Filamentous haemagglutinin family outer membrane protein, domain of unknown function DUF3739 + Putative flagellar system-associated repeat + Baseplate wedge protein gp53, bacteriophage T4 + Brain protein I3 + Phytoene dehydrogenase, bacterial-type, conserved site + DP-EP family + Domain of unknown function DUF5123 + Chromophore lyase CpcS/CpeS + Nitrogenase-associated protein + Bacteriophage lambda, GpZ, minor tail + Antitoxin RnlB/LsoB + Phage late-transcription coactivator + Protein of unknown function DUF4863 + Phage-associated protein, BcepMu gp16 family + Conjugative transposon, TraN + Copper transporter MctB + Carboxypeptidase, activation peptide + Ubiquitin-conjugating enzyme, E2, family E + InsA N-terminal domain + Flagellin, H7-serospecific domain + Uncharacterised protein family AF2234 + Protein of unknown function DUF1802 + Bacteriophage D3112, Orf24 + Hydroxypyruvate isomerase + Integrating conjugative element protein PFL4702 + Cellulose biosynthesis protein BcsS + Staygreen protein + SAM-dependent methyltransferase, NodS-related + SAM dependent carboxyl methyltransferase + Exonuclease V + Protein of unknown function DUF2666 + Chromosome partition protein MukF, C-terminal domain + Chromosome partition protein MukF, middle domain + Chemotaxis signal transduction system protein F + Transglycosylase-like + Pur operon repressor + Alpha 1,4-glycosyltransferase domain + Mitochondrial substrate/solute carrier + DNA sulphur modification system-associated protein 4 + Nitrogen fixation protein NifX + Photosystem II reaction centre protein Ycf12 + Domain of unknown function DUF4993 + ATPase, A1 complex, beta subunit + Domain of unknown function DUF4082 + 2-hydroxycarboxylate transporter + F420-dependent oxidoreductase-predicted, CPS4043 + Protein of unknown function DUF4235 + Putative aminophosphonate oxidoreductase + YkuI, C-terminal + Sporulation stage II, protein P + Stage V sporulation AD + Uncharacterised conserved protein UCP018814 + Peptidase S1C, DegS + Virulence factor YopE uncharacterised domain + Zn(II)-responsive transcriptional regulator + Uncharacterised protein family, VP2110 + Acid phosphatase, class A, bacterial, conserved site + Uncharacterised protein family UPF0184 + Cysteine desulphurase, catalytic subunit, CsdA + Sporulation protein YabP/YqfC + Protein of unknown function DUF3346 + O-phosphoseryl-tRNA(Sec) selenium transferase + Domain of unknown function DUF4469 with IG-like fold + Conserved hypothetical protein CHP03577, EF0830/AHA3911 + YolD-like protein + CpcD-like domain + Nudix hydrolase 6-like + Poxvirus A32 + Protein of unknown function DUF3225 + PELOTA RNA-binding domain + Chromophore lyase CpcT/CpeT + Protein of unknown function DUF2000 + SynChlorMet cassette radical SAM/SPASM protein ScmE + Protein of unknown function DUF2243, membrane + Lacto-N-biose phosphorylase-like, N-terminal TIM barrel domain + MatP, N-terminal + WavE lipopolysaccharide synthesis + Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 + CRISPR-associated protein, TM1812 + Phosphotransferase system, beta-glucoside-specific IIABC component + Avidin/streptavidin + Glucitol operon activator + Amino acid permease, conserved site + D-aminopeptidase/lipoprotein domain + Protein of unknown function DUF3400 + Protein of unknown function DUF1861 + Conjugative coupling factor TraG/TraD + Aspartate-alanine antiporter + Conserved hypothetical protein CHP03883, F420 biosynthesis associated + Protein of unknown function DUF2498 + Diol dehydratase-reactivating factor, alpha subunit, swiveling domain + Restriction endonuclease, type II, BpuJI, N-terminal + GTP-sensing helix-turn-helix, CodY, C-terminal + Trp repressor, bacterial + Protein of unknown function DUF2857 + SH2 domain + LRV FeS4 cluster + YozE SAM-like domain + Alkaline proteinase inhibitor/ Outer membrane lipoprotein Omp19 + mRNA interferase toxin YafO + 4Fe-4S binding protein + Xylella phage Xfas53, Orf42 + Minor capsid protein, bacteriophage + Conjugal transfer, TrbL + ParB protein family, C-terminal + Urea carboxylase + Amidohydrolase, AtzE type + Phosphoinositide phospholipase C, Ca2+-dependent + YopD-like + Domain of unknown function DUF1882 + Protein of unknown function DUF3431 + Glycoside hydrolase, family 25, active site + Protein of unknown function DUF2861 + Bacteriophage T4, Y12G + Glycoside hydrolase family 11/12 + Outer membrane lipoprotein RcsF + 2,3-diaminopropionate biosynthesis protein SbnB + Lantibiotic dehydratase, C-terminal + Protein of unknown function DUF1345 + Protein translocase subunit SecA, Actinobacteria-type + EGF-like, conserved site + Protein of unknown function DUF1838 + Luciferase-like, F420-dependent oxidoreductase, MSMEG2256, predicted + Domain of unknown function DUF4297 + Rhamnosyltransferase + Domain of unknown function DUF3825 + Sama2622-like domain + Protein of unknown function DUF4410 + Ribosomal RNA processing protein 8 + Protein of unknown function DUF5330 + DNA polymerase III, alpha subunit, Gram-positive type + Alpha-1,6-glucosidases, pullulanase-type + Citrate transporter + Photosystem I PsaL, reaction centre subunit XI + Aerolysin/Pertussis toxin APT + Muconate/chloromuconate cycloisomerase + YIEGIA protein + Protein of unknown function DUF5052 + 4-oxalocrotonate decarboxylase + GTP-sensing transcriptional pleiotropic repressor CodY, N-terminal + Immunity protein 27 + Immunity protein 10 + Low calcium response V antigen + Urea carboxylase-associated protein 1 + Dehydratase YjhG/YagF + Protein of unknown function DUF1413 + Protein of unknown function DUF1420 + Uncharacterised protein family UPF0167 + Protein of unknown function DUF5329 + Autonomous glycyl radical cofactor GrcA + Integrating conjugative element protein, PFL4709 + Sigma factor-binding protein Crl + Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, eukaryotic + Dihydrodipicolinate reductase, plant-type + Iron/zinc purple acid phosphatase-like C-terminal domain + Parvovirus non-structural protein 1, helicase domain + Protein of unknown function DUF1707 + PA-IL-like + Pilus assembly protein, C-terminal domain + XACb0070, ribbon-helix-helix domain + Formyl-CoA:oxalate CoA-transferase + Signal transduction histidine kinase, TMAO sensor TorS + TMAO reductase system, periplasmic protein TorT + TIP49, C-terminal + Poly-beta-1,6-N-acetyl-D-glucosamine biosynthesis protein PgaD + Protein of unknown function DUF4310 + Nif11-like leader peptide + Sortase system, histidine kinase + Ubiquitin conserved site + Secretion system effector C, SseC-like + Nitric oxide synthase, N-terminal + Immunity protein 22 + Microcompartment protein PduB + ATPase, RavA, C-terminal + Ornithine decarboxylase, N-terminal domain + Alpha-maltose-1-phosphate synthase + Pacifastin domain + DNA polymerase lambda, fingers domain + Protein of unknown function DUF2810 + Protein of unknown function with TPD sequence-motif + Protein of unknown function DUF1980 + Domain of unknown function DUF1983 + Flavivirus NS3, petidase S7 + Glycosyltransferase family 1, Daro2409 family + 2-component histidine kinase, sensor domain + Conserved hypothetical protein CHP03905 + Protein of unknown function DUF3792, transmembrane + DNA phosphorothioation-dependent restriction protein DptF + Repair of iron centres family + Purine-rich element binding protein family + Conserved hypothetical protein CHP03016, PEP-CTERM + Type II secretion system (T2SS) pilotin, S protein + Quinohemoprotein amine dehydrogenase, alpha subunit, haem binding domain + Stage III sporulation protein AH-like + Protein of unknown function DUF4928 + YXWGXW repeat + YqjK-like protein + Protein of unknown function DUF2581 + NAD(P)H-quinone oxidoreductase subunit M + Phosphotransferase system, mannitol-specific enzyme IIC + Fumarate reductase, flavoprotein subunit + SCIFF radical SAM maturase + Squalene-associated FAD-dependent desaturase + Rad9/Ddc1 + Viral late gene transcription factor 3 , zinc ribbon + Protein of unknown function DUF452 + Carbohydrate binding module family 25 + Serine proteases, V8 family, histidine active site + Amino acid antiporter + Granulocyte-macrophage colony-stimulating factor + MerE + TonB-system energizer ExbB type-2 + CRISPR-associated protein, Cas6-related + tRNase Z endonuclease + Peptidase U49, Lit peptidase + Peptidase M66 domain + Alkylmercury lyase, helix-turn-helix domain + Phosphotransferase system, sorbose subfamily IIB component, subgroup + B melanoma antigen + Two-component sensor protein CpxA, periplasmic domain + Protein of unknown function DUF3147 + Exosortase 1 + Lipopolysaccharide heptosyltransferase III, putative + Domain of unknown function DUF4975 + Protein of unknown function DUF2695 + Low affinity iron permease, Fet4 + Rhamnogalacturonan lyase, domain II + Type III secretion system effector delivery regulator TyeA + Phosphotransferase system, EIIC component, type 3 + Domain of unknown function DUF4351 + Protein of unknown function DUF3995 + Bifunctional rhamnulose-1-phosphate aldolase/alcohol dehydrogenase + Aldose 1-epimerase, bacterial + Protein of unknown function DUF3823 + Diacylglycerol kinase, accessory domain + LuxT regulator, C-terminal domain + MukB, hinge domain + Glycerol-3-phosphate transporter + Putative toxin of bacterial toxin-antitoxin pair + Protein of unknown function DUF2817 + REDY-like protein HapK + Catechol 1,2-dioxygenase, proteobacteria + Putative phosphonoacetaldehyde dehydrogenase + Type III secretion system effector delivery regulator TyeA-related + Protein of unknown function DUF5368 + NrfD + Cytochrome c nitrite reductase, Fe-S protein + Cytochrome c nitrite reductase, pentahaem subunit + Bacteriophage T4, Gp16, DNA-packaging + Ribosomal protein L34e, conserved site + Putative methyltransferase, LIC12133 family + Protein of unknown function DUF1344 + snRNA-activating protein complex, subunit 3 + Ergosterol biosynthesis ERG4/ERG24 + TMP repeat + Glycosyltransferase family 52 + Protein of unknown function DUF3748 + Protein of unknown function DUF3319 + Coronavirus Orf3 + Novel toxin 21 + Type III secretion sytem,YscO + CRISPR-associated protein Csx17, subtype Dpsyc + Lactobacillus prophage Lj928, Orf309 + Bacterial phospholipase C, C-terminal domain + Aspartic peptidase, DDI1-type + Conserved hypothetical protein CHP02304, F390 synthetase-related + Photosystem II cytochrome b559, alpha subunit, lumenal region + Sulphate ABC transporter, permease protein CysW + Phage infection protein, YhgE, N-terminal + Phage infection protein, YhgE, C-terminal + Conserved hypothetical protein CHP03067, planctomycetes + Oil body-associated protein-like + Bacteriophage clamp loader A subunit + CRISPR-associated protein, Csx11 + Siderophore ferric iron reductase, AHA1954 family + Bacteriocin, class IIb, lactobin A/cerein 7B family + Oxygen-independent coproporphyrinogen-III oxidase-like protein HemZ + Conserved hypothetical protein CHP02270 + Benzoyl-CoA reductase, subunit C + Benzoyl-CoA reductase, subunit D + Pectinacetylesterase/NOTUM + Plasmid regulator, Sulfolobaceae + Protein of unknown function DUF1878 + Allantoicase + Thiamine ABC transporter, permease protein + Formate acetyltransferase + Vitellinogen, beta-sheet N-terminal + ESCRT-II complex, Vps25 subunit, N-terminal winged helix + Protein of unknown function DUF5458 + CRISPR-associated RAMP TM1809 + Sporulation stage II, protein D firmicutes + Sucrose-6-phosphate hydrolase + Protein of unknown function DUF347 + Stage III sporulation protein AB + Sporulation protein YtxC + Novel toxin 15 + Calcium/proton exchanger CAX + Protein of unknown function DUF3577 + 3H domain + L27 domain + Mycoplasma P48 major surface lipoprotein + Putative bacterial toxin ydaT + F420-dependent oxidoreductase-predicted, Rv3520c + Pseudoazurin + Vibrio phage CTX, RstB + Peptidase U57, YabG + HARP domain + Ribonucleotide reductase Class Ib, NrdI + DNA polymerase III subunit tau, DnaB-binding domain IV + Protein of unknown function DUF1629 + Glycoside hydrolase, family 35, conserved site + Hen1, N-terminal + Hemagglutinin repeat + Protein of unknown function DUF4311 + Sporulation stage II, protein R + Benzylsuccinate synthase gamma subunit + Protein of unknown function DUF3487 + Potassium channel, voltage dependent, KCNQ + S-layer protein, N-terminal + KorB, C-terminal + Sortase system response regulator + Protein of unknown function DUF4241 + Glycoside hydrolase family 47 + Type III secretion system YscG + Protein of unknown function DUF3348 + Protein of unknown function DUF1422 + ABC-2 type transporter, NodJ + Restriction endonuclease, type II, Cfr10I/Bse634I + Domain of unknown function DUF1543 + Protein of unknown function DUF3304 + Benzoyl-CoA reductase, subunit B + Allene oxide cyclase/dirigent protein + Benzoyl-CoA reductase, subunit A + CAP Gly-rich domain + Planctomycete extracellular + Allantoicase domain + Plant ascorbate peroxidase + HprK-related kinase B + Domain of unknown function DUF4996 + Glycosyl transferase, family 13 + Uncharacterised protein family MJ0414 + DNA helicase (DNA repair), Rad3 type + Chromosome partition protein MukF, winged-helix domain + Alkylbase DNA glycosidase, conserved site + His-Xaa-Ser system protein HxsD + Chemotaxis methyl-accepting receptor, methyl-accepting site + Borrelia P83100 + Protein of unknown function DUF4893 + Glycerol-3-phosphate dehydrogenase, GlpB subunit + Uncharacterised protein family UPF0253 + Protein of unknown function DUF4134 + Domain of unknown function DUF3794 + Cysteine-rich secretory protein, allergen V5/Tpx-1-related + Transthyretin-like + Glycosyltransferase family 92 + Domain of unknown function DUF4224 + Toxin endonuclease, YhaV + Conjugative transposon, TraM + Domain of unknown function DUF3864 + Cystatin domain + Protein of unknown function DUF2933 + Dictyostelium (slime mold) repeat + Domain of unknown function DUF2433 + Type-IV b secretion system, inner-membrane complex component + Glycoside hydrolase, family 14 + S-adenosylmethionine decarboxylase + DNA-directed RNA polymerase subunit delta + Bacteriophage-associated immunity protein + MSEP-CTERM protein + Exosortase K + Glutathione synthase, alpha-helical, eukaryotic + SynChlorMet cassette protein ScmD + Glycolipid exporter Gap/Sap + Kelch repeat type 2 + Integral membrane protein YjbE + Protein of unknown function DUF4239 + MukB, N-terminal domain + F420-dehydrogenase, subunit FpoO + Calponin homology domain + Ubiquinone biosynthesis protein Coq4 + Conserved hypothetical protein CHP03788 + Parallel beta-helix repeat-containing domain + Cytochrome c-550 domain + Domain of unknown function DUF1833 + Protein of unknown function DUF1836 + Outer membrane protein Iml2/Tetratricopeptide repeat protein 39 + Protein of unknown function DUF4056 + Acid phosphatase, class A, bacterial + Clathrin, heavy chain, linker + Protein of unknown function DUF2259, secreted + Potassium-transporting ATPase A chain + Nitrate/trimethylamine N-oxide reductase NapE/TorE + Uncharacterised conserved protein UCP019883, membrane + Staphostatin A/B + Adenylylsulphate reductase, alpha subunit + Beta-1,4-galactosyltransferase + Telomere resolvase ResT + Protein of unknown function DUF4303 + Acidianus two-tailed virus, Orf117 + Domain of unknown function DUF4064 + Sulphate transport system permease protein 1 + Cytochrome f large domain + Type II secretion system protein N, conserved site + Mannan-binding protein + Protein of unknown function DUF5350 + Lipoprotein leucine-zipper + Cellulose biosynthesis protein BcsG + Cellulose biosynthesis protein BcsE + CshA-type fibril repeat + Protein of unknown function DUF1364 + Proteinase inhibitor I3, Kunitz legume + Protein-arginine deiminase, C-terminal + Nitrilotriacetate monooxygenase component A/pristinamycin IIA synthase subunit A + Transcription termination factor, mitochondrial/chloroplastic + Quinohemoprotein amine dehydrogenase, gamma subunit, structural domain + Domain of unknown function DUF2382 + Hemopexin, conserved site + Photosystem II protein D1 + Pa2218-like domain + Acetoin utilization protein AcuC + Protein of unknown function DUF3392 + Cysteine dioxygenase type I + Protein of unknown function DUF3389 + Poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB + Protein of unknown function DUF4836 + Protein of unknown function DUF1481 + CRIB domain + AntA/AntB antirepressor + RNA cap guanine-N2 methyltransferase + Putative outer membrane protein + Ubiquinol cytochrome reductase, transmembrane domain + Cyd operon protein YbgE + Proteasome component (PCI) domain + Ribonucleotide reductase, class 1b, subunit NrdE + Thiamine ABC transporter, ATP-binding protein ThiQ + Sulphate/thiosulphate-binding site + Phosphoribosylformylglycinamidine synthase, FGAM + CRISPR-associated protein, Csn2-type + Pilus biogenesis CpaD + Protein of unknown function DUF3199, YqbG + Replication protein A, C-terminal + mRNA (guanine-N(7))-methyltransferase domain + Uncharacterised protein family UPF0180 + Uncharacterised protein family UPF0181 + Protein of unknown function DUF2608 + ESPR domain + Trehalose operon repressor + Cecropin + Uncharacterised conserved protein UCP021328 + Phosphoserine phosphatase RsbU, N-terminal + Ubiquitin specific protease, conserved site + Deaminases, BURPS668_1122 family + Uncharacterised protein family CsiD + Diol dehydratase-reactivating factor alpha subunit + Peptidase S1A, streptogrisin + GGGtGRT protein + Mitochondrial degradasome RNA helicase subunit, C-terminal domain + Protein of unknown function DUF3069 + TonB system transport protein ExbD type-2 + Protein of unknown function DUF3094 + Glycosyl hydrolase family 100 + 2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT2 + ABC transporter, membrane fusion protein, DevB type + Trimethylamine N-oxide reductase system, TorE + Phage shock protein, PspG + Sucrose phosphorylase GftA + Protein of unknown function DUF2004 + Gamma interferon inducible lysosomal thiol reductase GILT + Protein with unknown function UPF0154 + Peptide-N-glycosidase F, C-terminal + Hedgehog, N-terminal signalling domain + Uncharacterised conserved protein UCP021940 + Holin, r1t-type + Phytochelatin synthase + Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain + Bacterial Ig-related + U box domain + Vibrio phage Vf33, Vpf117 + Restriction endonuclease, type II, FokI, N-terminal + Domain of unknown function DUF4031 + Chalcone isomerase, orthogonal bundle domain + Citrate synthase, eukaryotic-type + Arsenite oxidase, large subunit + Hopanoid-associated sugar epimerase + RNA-binding S4-related,YaaA + Clostridial hydrophobic repeat + YcaO domain protein + Photosystem II cytochrome b559, alpha subunit + Lyase, N-terminal + Ribosome recycling factor. bacterial + Protein of unknown function DUF2380 + Protein of unknown function DUF2115 + Carbonic anhydrase, cadmium-binding + Knottin, scorpion toxin-like + Protein of unknown function DUF2280 + D-erythrose-4-phosphate dehydrogenase + Portal protein, SPP1-type + DREV methyltransferase + Dimethylsulphoxide reductase, chain B + Protein of unknown function DUF4924 + Protein of unknown function DUF1104 + LuxQ, periplasmic + Restriction endonuclease, type II, FokI, catalytic domain + His-Xaa-Ser system radical SAM maturase HxsC + Precorrin 3B synthase CobZ + Citrate utilization protein B + Holliday junction resolvase, A22 + Lipid A biosynthesis myristoyltransferase + Protein of unknown function DUF3565 + Beta-carotene 15,15'-monooxygenase, Brp/Blh family + Putative sugar phosphate phospholyase (cyclising) + Phosphonoacetate hydrolase + Protein of unknown function DUF1492 + Ferredoxin [2Fe-2S], plant + Arsenical-resistance operon trans-acting repressor ArsD + Photosynthetic complex assembly protein 2, putative + Heme utilization protein with pyridoxamine 5'-phosphate domain + Putative Na+/H+ antiporter + Histone H1-like nucleoprotein HC2 + Universal stress protein B + Mig-14 + Defensin propeptide + Conserved hypothetical protein CHP00743 + Predicted archaeal flagellar protein C + Putative motility protein + Peptidase S59, nucleoporin + Bacterial shufflon protein, N-terminal + Domain of unknown function DUF3863 + Formate-dependent cytochrome c nitrite reductase, c552 subunit + Glutaredoxin-2 + Domain of unknown function DUF4829 + Protein of unknown function DUF2278 + Protein of unknown function DUF3624 + Alpha-L-arabinofuranosidase B, arabinose-binding domain + Domain of unknown function DUF2231, transmembrane + T4-type lysozyme + Thiamine pyrophosphokinase C-terminal + Flagellar export ATPase FliI, clade 2 + Alpha-N-acetylglucosaminidase, N-terminal + Putative carbamoyltransferase YgeW + Alternate ATP synthase, F0 complex, subunit b + Ethanolamine/propanediol utilisation protein, EutP/PduV + ABC transporter, methionine import, ATP-binding protein MetN, proteobacteria + Histidine decarboxylase proenzyme + Uncharacterised protein family, nitrogen regulatory protein PII-related + Uncharacterised protein family Atu4866 + ATPase, type III secretion system, H+-transporting + Type III secretion system apparatus protein YscQ/HrcQ/SpaO + Homospermidine synthase-like, domain + Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal type + Enterochelin esterase, N-terminal + Protein of unknown function DUF4004 + Type-2 restriction enzyme NlaIV + Protein of unknown function DUF4856 + RecG, N-terminal antiparallel four helix bundle + Tellurite resistance protein TehA/malic acid transport protein + Flagellar protein FlhE + Zinc finger, RING-type, conserved site + Gonadotropin-releasing hormone + Lantibiotic biosynthesis protein, dehydration domain + Immunoglobulin I-set + Lipoprotein-releasing system transmembrane protein LolC/E, gammaproteobacteria type + Exosortase 1 system-associated amidotransferase 1 + GNAT-acetyltransferase + Hydrolase, ortholog 1, exosortase system type 1 associated + Sulphur globule protein + Sigma factor regulator C-terminal domain + Major capsid protein, N-terminal + Recombination enhancement, RecA-dependent nuclease + Conjugal transfer/type IV secretion protein DotA/TraY + Thiazole/oxazole-forming peptide maturase, SagD family component + Stage III sporulation protein AC/AD family + Protein KTI12/L-seryl-tRNA(Sec) kinase + Protein of unknown function DUF1646 + Fimbrial-type adhesion domain + Domain of unknown function DUF3376 + DNA polymerase III polC-like, N-terminal domain II + PIK-related kinase, FAT + Bicarbonate transporter, C-terminal + Glycogen debranching enzyme, glucanotransferase domain + Cellulose synthase, subunit B + SpoVA + Protein of unknown function DUF2171 + Protein of unknown function DUF3309 + Restriction endonuclease, type II, HincII + DDRGK domain containing protein + Domain of unknown function DUF4253 + Muconolactone delta-isomerase + Glycoside hydrolase, family 68 + Ribosome-inactivating protein, subdomain 1 + Leucine-rich repeat-containing N-terminal, plant-type + Mercuric transport protein periplasmic component + Pilus assembly protein, E-set like domain + Azurin + Protein of unknown function DUF4855 + Allergen V5/Tpx-1-related, conserved site + Domain of unknown function DUF3597 + Extracellular endo-alpha-(1->5)-L-arabinanase, C-terminal + Putative component of 'biosynthetic module' + Protein of unknown function DUF4343 + LCCL domain + Beta-ketoadipate transcriptional regulator, PcaR/PcaU/PobR + Immunoglobulin/major histocompatibility complex, conserved site + Protein of unknown function DUF2895 + Tn7 transposition regulator TnsC + Vibrio phage VSK, Orf152 + Mercury ion transport, MerF + Peptidase M12A + Cytidine deaminase, homodimeric + Putative bacteriocin export ABC transporter, lactococcin 972 group + Domain of unknown function DUF5071 + Cysteine-rich CPCC domain + Domain of unknown function DUF5106 + Gammaproteobacterial periplasmic sensor domain GAPES4 + Pyridoxal phosphate-dependent enzyme, SelA-like + Protein of unknown function DUF496 + Guanine-specific ribonuclease N1/T1/U2 + Ribophorin I + Amine dehydrogenase heavy chain + Pyrophosphate-dependent phosphofructokinase PfpB + Protein of unknown function DUF4860 + Chorismate mutase, Gram-positive + Streptococcal non-M secreted SibA + Bacteriocin biosynthesis, cyclodehydratase domain + Integrating conjugative element protein, PFL4693 + TATA box binding protein associated factor (TAF) + Adhesin operon regulatory protein + Protein of unknown function DUF3189 + Protein of unknown function DUF3188 + Protein of unknown function DUF2508 + Glycoprotein E central domain, subdomain 2 + Glycoside hydrolase, family 8, conserved site + NAD:arginine ADP-ribosyltransferase, ART + Protein of unknown function DUF4862 + Uncharacterised conserved protein UCP014484, transmembrane + Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain + Selenium-dependent xanthine dehydrogenase + ATP synthase subunit beta, bacterial and archaeal + Uncharacterised protein family AF1718 + Glycosyl hydrolases family 10, active site + Stealth protein CR4, conserved region 4 + Photosystem II cytochrome b559, beta subunit + Protein kinase C-like, phorbol ester/diacylglycerol-binding domain + Conjugal transfer, TraD, alpha-type + Beta-1,4-N-acetylgalactosaminyltransferase + Domain of unknown function DUF5006 + DNA topoisomerase IV subunit A, Gram-positive + DNA topoisomerase 4 subunit B, Firmicutes/Mollicutes + Baseplate tail-tube protein gp48, T4-like virus + HisA/HisF-like protein + Essential protein Yae1, N-terminal + Ubiquitin-conjugating enzyme E2-binding protein + Long-chain fatty aldehyde decarbonylase + Benzoate 1,2-dioxygenase, small subunit + Bacterial EndoU nuclease + STAT transcription factor, DNA-binding, subdomain + Small acid-soluble spore protein, SspH + Uncharacterised protein family Ycf36 + Phenolic acid decarboxylase, bacterial + YmaF + DotD protein + Sporulation delaying protein SdpA + Ubiquitin system component Cue + Protein of unknown function DUF930 + Domain of unknown function DUF4937 + Cytochrome b6/f complex, subunit 5 + Apoptosis inhibitory 5 + HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase + Protein of unknown function DUF3455 + PAM68-like + C-type cytochrome, methanol metabolism-related + Protein AC76, baculovirus + Protein-arginine deiminase (PAD), central domain + CRISPR-associated protein Csm6 + Vacuolating cytotoxin + Protein phosphatase inhibitor 2 (IPP-2) + Decahaem cytochrome, c-type, OmcA/MtrC + Hg(II)-responsive transcriptional regulator + Zinc finger, MYND-type + Cell wall/choline-binding repeat + Arsenical pump-driving ATPase + MHC class I-like antigen recognition-like + Protein of unknown function DUF5335 + ATP synthase alpha chain, archaea + Protein of unknown function DUF2024 + Histone acetyl transferase HAT1 N-terminal + DNA-directed RNA polymerase Rpb11, 13-16kDa subunit, conserved site + Domain of unknown function DUF5126 + Translation Initiation factor eIF- 4e + CxxC-20-CxxC protein + Protein of unknown function DUF4385 + Domain of unknown function DUF3875 + MAD homology, MH1 + CSN8/PSMD8/EIF3K + Transposase (putative), N-terminal + Probable zinc-ribbon domain, plant + Di-heme enzyme, MXAN0977 + Protein of unknown function DUF1380 + Haemolysin XhlA + HSR domain + Protein of unknown function DUF3483 + Sporulation protein YqfC + Molybdate-anion transporter + Herpesvirus UL92 + Type III secretion, needle-protein-like + Cobalt transport protein CbiN + Protein of unknown function DUF4312 + XisI protein + Protein of unknown function DUF1830 + Putrescine transporter PotE + DNA phosphorothioation-associated DGQHR protein 1 + Peptidase S28 + Adenovirus large t-antigen, E1B 55kDa protein + Magnesium chelatase, ATPase subunit D + Cytochrome b6/f complex, subunit IV + Spore coat protein CotJA + Protein of unknown function DUF2917 + Vacuolar protein sorting protein 36, GLUE domain + Quinoprotein relay system zinc metallohydrolase 1 + Protein of unknown function DUF2242 + 26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1 + Six-cysteine peptide SCIFF + Cullin, conserved site + Mitochondrial ribosomal protein MRP51, fungi + Putative pyrophosphorylase ModD + Carboxysome shell protein + Bacteriophage RNA-type, capsid + Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2 + FeS assembly scaffold SufA + PTS system glucose-specific IIBC component + Domain of unknown function DUF2345, Vgr C-terminal + Chloroplast protein import component Tic20 + Cytochrome C oxidase, subunit VIIB, domain + Conserved hypothetical protein CHP03829, YokU + Protein of unknown function DUF810 + Magnesium transporter NIPA + Protein of unknown function DUF2505 + Acyl transferase, LuxD + Hemingway/KIAA1430 + Molybdenum-binding protein ModE, N-terminal + Protein of unknown function DUF1816 + Protein of unknown function DUF1818 + HMG-I/HMG-Y, DNA-binding, conserved site + Protein of unknown function DUF5041 + Quinohemoprotein amine dehydrogenase, gamma subunit maturation protein + Quinohemoprotein amine dehydrogenase, alpha subunit + Manganese catalase, domain 2 + 7TM GPCR, serpentine receptor class t (Srt) + 7TM GPCR, serpentine chemoreceptor class i (Sri) + VWFC domain + SANT/Myb domain + Protein of unknown function DUF273 + Type III secretion system, secretion protein E + Type III secretion system, YscI/HrpB + Type III secretion system chaperone SycN + Type III secretion system YscX + Protein of unknown function DUF4221 + Phosphotransferase system, alpha-glucoside-specific IIBC component + Fatty acyl-CoA reductase, C-terminal + Protein of unknown function DUF2944 + tRNA methyltransferase TrmK + Amino acid transporter, transmembrane domain + Uncharacterised domain AF0941 + Protein import receptor MAS20 + Cadmium resistance transporter + Bacteriophage M13, G5P, DNA-binding + Sensitivity To Red Light Reduced-like, SRR1 + Glycoside hydrolase, family 33, N-terminal + Protein of unknown function DUF986 + Dim1 family + Ferric iron reductase + Protein of unknown function DUF1870 + Af2093, N-terminal + Minor capsid protein, putative + PetM of cytochrome b6/f complex subunit 7 + Dicarboxylate-CoA ligase PimA + p53, tetramerisation domain + Zinc finger, ZZ-type + Peptidase M12B, propeptide + Septation ring formation regulator EzrA + Whirly transcription factor + Predicted [NiFe]-hydrogenase-3-type complex Eha, membrane protein EhaE + Predicted [NiFe]-hydrogenase-3-type complex Eha, membrane protein EhaF + NMB0513-like domain + X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal domain + MOB kinase activator family + Phosphomannomutase + Hemolytic lectin CEL-III, C-terminal domain + ATP synthase, F0 complex, subunit B/MI25 + Phage-associated protein HI1409 + Insertion element IS1 protein InsA, helix-turn-helix domain + Protein of unknown function DUF346 + Signal recognition particle receptor, beta subunit + Protein of unknown function DUF4362 + Thrombospondin type-1 (TSP1) repeat + BphX-like + Flagellar assembly regulator FliX, class II + UDP-glycosyltransferase family, conserved site + Porin family, mycobacterial-type + Type III secretion protein HrcV + Type III secretion protein SpaR/YscT + Type III secretion protein HrpO + VDE lipocalin domain + Phosphomevalonate kinase + Integrin alpha chain, C-terminal cytoplasmic region, conserved site + Rhombotail lipoprotein + Phosphomutase MSMEG4193, putative + Protein of unknown function DUF3060 + Stage V sporulation protein AE + Type III secretion system lipoprotein HrcJ/YscJ + Benzoate 1,2-dioxygenase, large subunit + CRISPR-associated protein Cas1, cyanobacteria-type + Conserved hypothetical protein CHP04042, MSMEG0570 + Conserved hypothetical protein CHP04044, MSMEG0572 + Luciferase-like, F420-dependent oxidoreductase, MSMEG4141, predicted + Spc7 kinetochore protein domain + Domain of unknown function DUF5057 + Protein of unknown function DUF5054 + Rotavirus NSP2, N-terminal + ParB-related, ThiF-related cassette, ParB + HAD-superfamily hydrolase, subfamily IB, PSPase-like, archaeal + Protein of unknown function DUF2993 + Trehalose-6-phosphate hydrolase + Malto-oligosyltrehalose trehalohydrolase + Maltooligosyl trehalose synthase + Type III secretion system, low calcium response, chaperone LcrH/SycD + Domain of unknown function DUF1725 + Domain of unknown function DUF4394 + Parvovirus coat protein VP2 + Transcription regulator PadR, acidobacterial-type + Tropomyosin + Zinc finger, FLYWCH-type + Protein of unknown function DUF2634 + Yop protein translocation protein D, periplasmic domain + Type VI secretion system (T6SS), amidase immunity protein + Membrane attack complex component/perforin domain, conserved site + MbeD/MobD-like + Domain of unknown function DUF1990 + Tyrosine 2,3-aminomutase, putative + YecR-like lipoprotein + CRAL-TRIO lipid binding domain + Magnesium chelatase, subunit H, N-terminal + Jacalin-like lectin domain + GTP cyclohydrolase N-terminal + Protein of unknown function DUF3086 + Protein of unknown function DUF3088 + Ribosomal RNA methyltransferase Spb1, domain of unknown function DUF3381 + CbxX/CfqX, monofunctional + Type III secretion system chaperone YscB + Heterokaryon incompatibility + Conserved hypothetical protein CHP04066, peptide maturation system + Protein of unknown function DUF4355 + Protein of unknown function DUF4823 + Glucosylglycerol-phospate 3-phosphatase + 3'5'-cyclic nucleotide phosphodiesterase, conserved site + Vacuolar protein sorting-associate protein Vta1/Callose synthase, N-terminal domain + Type III secretion system, secretion protein K + Retrovirus capsid, C-terminal + Malonate transporter MadL subunit + RNA polymerase Rpb1, domain 6 + Conserved hypothetical protein CHP03792 + BCP1 family + Porin, Neisseria sp. type + CAP, conserved site, N-terminal + Cyanobacterial aminoacyl-tRNA synthetase, CAAD domain + Domain of unknown function DUF4334 + Arylesterase + Photosystem I PsaF, reaction centre subunit III + Putative tight adherence pilin protein F + Ti-type conjugative transfer relaxase TraA + 4-hydroxybenzoyl-CoA reductase, alpha subunit + Sporulation stage III, protein AF + Fibro-slime + B domain of TMEM189, localisation domain + Tetratricopeptide, SHNi-TPR domain + Putative lipoprotein, rSAM/lipoprotein system + Protein of unknown function DUF2811 + NFkB-p65-degrading zinc protease + Methane monooxygenase, gamma chain + Sporadic carbohydrate cluster 2-oxoglutarate-Fe(II) oxygenase + Integrin beta N-terminal + Conserved hypothetical protein CHP04046, FMN-dependent + Protein of unknown function DUF3846 + Methane monooxygenase, gamma chain, domain 2 + Methane monooxygenase, gamma chain, domain 1 + Phosphonate degradation operon associated HDIG domain protein + Coenzyme F420 hydrogenase, subunit beta + Peptide modification radical SAM enzyme + DNA phosphorothioation-dependent restriction protein DptH + Gas2-related domain + Cysteine desulfurase DndA + Coactivator CBP, KIX domain + BAG domain + Sulphur oxygenase reductase + Viral replication-associated protein, N-terminal + ABC transporter ATP-binding subunit, DevA type + Tetraspanin, EC2 domain + Antenna complex, alpha subunit conserved site + Pesticidal crystal protein, N-terminal + PH1570-like domain + NTF2 fold domain + Conserved hypothetical protein CHP02664, nitrate reductase-associated + DENN domain + YjzC-like protein + Centromere protein Cenp-F, leucine-rich repeat-containing domain + Putative stress-induced transcription regulator + P-type ATPase, subfamily IIA, PMR1-type + Protein of unknown function DUF1904 + Type-IV secretion system protein TraC + Type-F conjugative transfer system protein TrbI + Bleomycin resistance protein + Uncharacterised protein family, LppY/LpqO + Glycoside hydrolase, family 45 + Bacterial proteasome activator + Protein of unknown function DUF2690 + Phage terminase small subunit + GXWXG domain + Phosphotransferase system, maltose/glucose-specific subfamily IIC component + Protein of unknown function DUF229 + Autophagy protein Atg8 ubiquitin-like + Protein of unknown function DUF1556 + Immunodeficiency virus transactivating regulatory protein (Tat) + Type IV conjugative transfer protein TrbJ + Helicase Cas3, CRISPR-associated, Yersinia-type + Propionate--CoA ligase + Decaheme cytochrome, c-type, DmsE + Tyrosine-protein kinase ephrin type A/B receptor-like + Peptide-modifying radical SAM enzyme CbpB + VPEID-CTERM protein sorting domain + Exosortase E/protease, VPEID-CTERM system + Spore coat protein X/V + Cell division protein FtsN + Sigma-E processing peptidase SpoIIGA + RGS, subdomain 1 + Protein of unknown function DUF1173 + Polynucleotide kinase-phosphatase, C-terminal + Cobalamin (vitamin B12) biosynthesis protein CbiM + Lysine-2,3-aminomutase-related + Spanin, inner membrane subunit + Plastocyanin + Domain of unknown function DUF1910 + CheY binding + Lipoprotein, putative + Conserved hypothetical protein CHP03806, HNE0200 family + PelD, GGDEF domain + Signal transduction histidine kinase/phosphatase, lantibiotic regulatory protein MprB + Domain of unknown function DUF2262 + Duffy antigen/chemokine receptor + Zinc finger, UBP-type + AmpG-like permease/Acetyl-coenzyme A transporter 1 + Immunity protein 26 + Signal transduction response regulator, propionate catabolism, transcriptional regulator PrpR + Circadian clock protein KaiB + MDMPI C-terminal + 1, 4-beta cellobiohydrolase + Zinc finger, HIT-type + Bride of sevenless protein + DNA topoisomerase II, eukaryotic-type + UV radiation resistance protein/autophagy-related protein 14 + Tryptophan 2,3-dioxygenase, bacterial + Kynurenine formamidase, bacteria + 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase + Poxvirus VLTF3, late transcription factor + Protein of unknown function DUF4943 + Acyltransferase, C-terminal domain + Exostosin , C-terminal + FYVE zinc finger + Pyrimidine dimer DNA glycosylase + Spore coat assembly protein CotJB, domain + Inverse autotransporter, beta-domain + Domain of unknown function DUF3421 + von Hippel-Lindau disease tumour suppressor, alpha domain + Sucrose phosphate synthase, sucrose phosphatase-like domain + Papillomavirus E7 + Cysteine desulfurase NifS, proteobacteria + Pleckstrin-like, plant + Uncharacterised conserved protein UCP015278 + TNFR/NGFR cysteine-rich region + F-box domain + T4 recombination endonuclease VII, dimerisation + Gcn5-related N-acetyltransferase (GNAT) domain, ATAT-type + mRNA capping enzyme, C-terminal + Stage III sporulation protein AC + Pectinesterase, Tyr active site + Pili assembly chaperone, conserved site + Rhabdovirus nucleocapsid, C-terminal + HD containing hydrolase-like enzyme + AbrB-like transcriptional regulator + Domain of unknown function DUF2027 + Protein of unknown function DUF3619 + Serine incorporator/TMS membrane protein + GUN4-like + Serine-tRNA ligase, class IIa, archaea + Protein of unknown function DUF4291 + Zinc finger, nuclear hormone receptor-type + Arp2/3 complex subunit 2/4 + L-fuculokinase + Protein of unknown function DUF4089 + Replication initiator A, N-terminal + Phasin, subfamily 2 + Delta antigen, N-terminal domain + Protein of unknown function DUF530 + GTP-sensing transcriptional pleiotropic repressor CodY + DNA helicase subunit AddA + Mitochondrial carrier protein + Protein N-terminal asparagine amidohydrolase + Monopolin complex subunit Lrs4/Mde4 + Protein of unknown function DUF2086 + Ax21 family + Histone H3/CENP-A + Folate-sensitive fragile site protein Fra10Ac1 + 5-dehydro-4-deoxyglucarate dehydratase + Type III secretion system needle length determinant, C-terminal domain + Sugar transferase, PEP-CTERM, Stp2 + Nickel-responsive transcriptional regulator NikR, proteobacteria + Formate-dependent nitrite reductase complex, subunit NrfF + Restriction endonuclease BpuSI, N-terminal domain + TLDc domain + Phenylacetic acid degradation protein PaaY + Protein of unknown function DUF2511 + Conserved hypothetical protein CHP04073, exosortase-affiliated + Peptidase S8A, tripeptidyl peptidase II + Sporadic carbohydrate cluster protein, LIC12192 family + CRISPR-associated protein Cas4, PREFRAN subtype + Glycosyl transferase, family 6 + T-complex 11 + Uncharacterised protein family YhfT + Restriction endonuclease, type II, MspI + Glutathione synthase, substrate-binding, eukaryotic + Bacteriophage T4, Gp8 + Villin headpiece + Cyclodileucine synthase + Restriction endonuclease, type II SfiI + Nitrogenase iron-iron, accessory protein AnfO + Protein of unknown function DUF3213 + Barnase + Uncharacterised protein family UPF0021, conserved site + Protein of unknown function DUF4824 + Alpha-2,3-sialyltransferase + Tim10/FAM136A-like domain + Protein of unknown function DUF829, TMEM53 + Protein of unknown function DUF3516 + Putative aromatic acid exporter, C-terminal + Cysteine oxygenase/2-aminoethanethiol dioxygenase + 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase + 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit + 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, N-terminal subunit + 7TM GPCR, serpentine receptor class e (Sre) + Protein of unknown function DUF4320 + Ciliary BBSome complex subunit 2, middle region + Phage tail tube protein 3 + Type III exporter system, secretion apparatus protein BsaZ + Uncharacterised protein family Ycf33 + Sigma factor regulator, N-terminal + Siderophore iron transporter 1/trichothecene efflux pump Tri12 + Ubiquitin-conjugating enzyme, active site + Anti-Sigma Factor A + Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3 + Legume-like lectin + Restriction endonuclease, type II, HaeIII + Pertactin, central region + Immunity protein Imm5 + Protein of unknown function DUF1660 + Protein of unknown function DUF1236 + Domain of unknown function DUF4314 + Protein of unknown function DUF4317 + Nuclear hormone receptor, ligand-binding domain + Double-stranded RNA-specific adenosine deaminase (DRADA) + Link domain + PGDYG protein + Molybdenum cofactor biosynthesis protein F, N-terminal + Agmatine deiminase + CRISPR-associated protein Cas5, bacterial + Negative regulator of genetic competence, MecA + Zinc finger, RING-CH-type + Photosystem II cytochrome b559, N-terminal + Domain of unknown function DUF4396 + Sporulation protein YunB + Sporulation stage III, protein AE + D-(-)-3-hydroxybutyrate oligomer hydrolase, putative + LydA-holin antagonist LydB + Protein of unknown function DUF3579 + PE-PPE, C-terminal + Schwannomin interacting protein 1 + Type III secretion system HrpE/YscL + Type III secretion system YscD/HrpQ + Peptidase M23A, B-lytic metalloendopeptidase + K+ transporting P-type ATPase, F subunit + Protein of unknown function DUF4133 + Peptidase C2, calpain, catalytic domain + Alpha-amylase C-terminal, prokaryotic + F420-dependent oxidoreductase-predicted, Rv1855c + Phosphotransferase system, sucrose-specific IIBC component + Uncharacterised conserved protein UCP037672 + Protein of unknown function DUF529 + Cathepsin propeptide inhibitor domain (I29) + Protein of unknown function DUF3873 + Dynein heavy chain, hydrolytic ATP-binding dynein motor region D1 + Apolipoprotein A/E + Protein of unknown function DUF5334 + C-terminal associated domain of TOPRIM + Domain of unknown function DUF5069 + Phage protein Gp45.2 + Carboxysome shell carbonic anhydrase + Phosphate butyryltransferase + Hypersensitivity response secretion-like, HrpJ + Immunity protein CdiI + Protein of unknown function DUF3258 + B transposition protein, C-terminal + F-actin capping protein, beta subunit, conserved site + 1-aminocyclopropane-1-carboxylate deaminase + Chromosome passenger complex (CPC) protein INCENP N-terminal + Restriction endonuclease, type II, HindVP + Zn(2)-C6 fungal-type DNA-binding domain + Domain of unknown function DUF3885 + D-fructose-responsive transcription factor + Carbon-monoxide dehydrogenase, large subunit + L-ribulose-5-phosphate 3-epimerase + Tudor domain + Copper amine oxidase + Herpesvirus major outer envelope glycoprotein + CDR ABC transporter + Sporulation stage V, protein AE + Relaxosome protein TraY + Fimbrial major subunit, CS1-type + Integrating conjugative element, PFGI-1, ParB + Conjugative transfer ATPase + Integrating conjugative element protein PFL_4710 + HEXXH motif domain + Radical SAM protein, BA_1875 family + Bacteriocin, class IIb, lactacin-related + Protein of unknown function DUF1590 + Protein of unknown function DUF4257) + Poly(ADP-ribose) polymerase, catalytic domain + Nuclear fusion protein, KAR5 + Uncharacterised protein family Ycf34 + Antirepressor protein ANT, N-terminal + Eukaryotic translation initiation factor 3-like domain + Bacteriophage P22, Orf201, C-terminal + Protein-tyrosine phosphatase, YopH, N-terminal + CRISPR-associated protein Csn2 subfamily St + Protein of unknown function DUF2624 + Protein of unknown function DUF1419 + Type III secretion protein, LcrG + TATA-box binding + Surfeit locus 4 + Protein of unknown function DUF4879 + Protein of unknown function DUF4876 + Malonate/sodium symporter MadM subunit, N-terminal + Cyclin, C-terminal domain + Protein of unknown function DUF620 + TOBE-like domain + Vacuolar protein sorting protein 11, C-terminal + CS domain + Small/middle T-antigen + Immunity protein 32 + Yop virulence translocation protein R + NADH:ubiquinone oxidoreductase, chain 2 + Protein of unknown function DUF4843 + Bacteriophage 82, GpQ + CofD-related protein, GAK system + Protein of unknown function DUF5004 + Protein of unknown function DUF1580 + Rubisco LSMT, substrate-binding domain + Galectin, carbohydrate recognition domain + Protein of unknown function DUF4363 + Domain of unknown function DUF4368 + Spore coat protein CotF-like + Protein of unknown function DUF5411 + Glyoxylate carboligase + Conserved hypothetical protein CHP04081, GSU1558 + Thioester reductase-like domain + Conserved hypotheical protein CHP04052 + HAD-superfamily hydrolase, subfamily IIA, hypothetical 1 + Histidine phosphatase superfamily, clade-2 + Protein of unknown function DUF4900 + Uncharacterised protein YqbF domain + Uncharacterised protein family Ycf51 + Glycoside hydrolase, family 59 + Fork head domain conserved site 2 + Ion channel regulatory protein, UNC-93 + Natural product precursor, GG-Bacteroidales + Fascin domain + Transcription factor homeodomain, male germ-cell + TRPM, tetramerisation domain + Brinker DNA-binding domain + Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain + Interferon/interleukin receptor domain + Protein of unknown function DUF3936 + Domain of unknown function DUF1842 + Xanthosine phosphorylase + GTP-binding protein, riobosome biogenesis, YqeH + CRISPR-associated protein Cas8a1/Csx13, Myxan subtype, N-terminal + cGMP-dependent protein kinase, N-terminal coiled-coil domain + Protein of unknown function DUF3836 + Ubiquitin/SUMO-activating enzyme E1 + [NiFe]-hydrogenase-3-type complex Eha, membrane protein EhaH, predicted + Bacterial toxin 23 + Gp5, C-terminal + F-box associated (FBA) domain + Non-ribosomal peptide synthase + Nitrilase-related, sll0784 + Dicarboxylate carrier MatC N-terminal + Domain of unknown function DUF4874 + HtrL protein + MRG domain + Protein of unknown function DUF694 + Type III secretion system regulator LcrR/Chaperone CesD2 + Chlorophyll A-B binding protein + Protein of unknown function DUF3172 + DNA replication factor RFC1, C-terminal + Protein of unknown function DUF3599 + 2-oxopent-4-enoate hydratase + Type-2 restriction enzyme, D3 domain + Gemin2/Brr1 + Alginate O-acetyl transferase AlgF + Glycosyl amidation-associated protein, WbuZ + N-terminal acetyltransferase A, auxiliary subunit + Phage tail tube protein 1 + Putative abortive phage resistance protein AbiGii toxin + Glutathione synthase, N-terminal, eukaryotic + Protein of unknown function DUF3408 + Protein FRG1 + Photosystem I PsaM, reaction centre + Eight-cysteine-cluster domain + Aerolysin + Rhodopsin, N-terminal + Integrase, C-terminal, retroviral + rSAM-associated Gly-rich repeat protein + Salicylate biosynthesis protein PchB + Nuclear pore localisation protein Npl4, ubiquitin-like domain + Glutathione synthase domain + Domain of unknown function DUF3566. transmembrane + Sulfolobus islandicus filamentous virus, Orf14 + Mitogen-activated protein (MAP) kinase, conserved site + Galactose-1-phosphate uridyl transferase, class II, conserved site + DUSAM domain + Myxococcus xanthus paralogous protein 2265 + Methionyl-tRNA synthetase, N-terminal heteromerisation domain + Phospholipase C, phosphatidylinositol-specific, Y domain + Stress-induced protein, KGG, repeat + Protein of unknown function DUF2491 + Domain of unknown function DUF4474 + Ribosome-inactivating protein + Vertebrate-like NAGS Gcn5-related N-acetyltransferase (GNAT) domain + KGK + General stress protein 17M-like domain + PapC, N-terminal domain + Zinc finger, TAZ-type + Rab-GTPase-TBC domain + Putative glycolipid-binding protein + CRISPR-associated endonuclease Cas9, bridge helix + Bor + Immunity protein 53 + Spore photoproduct lyase + Pkip-1 + Photosystem II D2 protein + Bacteriophage N4 adsorption protein A, C-terminal + Protein of unknown function DUF3243 + Protein of unknown function DUF3238 + Peptidase C14A, caspase catalytic domain + Membrane lipoprotein, lipid attachment site + RNA ligase, DRB0094 + Uncharacterised protein family FAM171 + GPCR fungal pheromone mating factor, STE2 + Lipid-binding, putative + WYL domain containing protein + Putative member of DMT superfamily + Meiotic recombination, Spo11 + Chlamydia cysteine-rich outer membrane protein 6 + Uncharacterised conserved protein UCP028477 + Signal transduction histidine kinase, osmosensitive K+ channel sensor, N-terminal + Ribosomal protein L37e, conserved site + P40 nucleoprotein, subdomain 1, Borna disease virus + Protein of unknown function DUF3370 + HeH/LEM domain + SUKH-3 immunity protein + Bypass of forespore C, C-terminal + Claudin, conserved site + [NiFe]-hydrogenase-3-type complex Eha, subunit EhaM + Sporulation transcription factor Spo0A + 4-hydroxybenzoyl-CoA reductase, beta subunit + Lipopolysaccharide core heptose(II) kinase + Cytochrome b-c1 complex subunit 7 + Type IV pilus biogenesis PilP + Reeler domain + 2',3'-cyclic-nucleotide 3'-phosphodiesterase + Quinone modification maturase, putative + Poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA + PapC-like, C-terminal domain + Protein of unknown function DUF2887 + Protein of unknown function DUF3764 + Domain of unknown function DUF4033 + Domain of unknown function DUF4034 + Phosphotransferase system, trehalose-specific IIBC component + Lysyl oxidase + Endosialidase, beta propeller domain + Endosialidase, beta barrel domain + Protein of unknown function DUF5132 + WLM domain + Uricase + Glycosyl hydrolase family 98, central domain + Protein of unknown function DUF5455 + Invertebrate-type lysozyme + Lepidopteran low molecular weight lipoprotein + Protein of unknown function DUF993 + SPRY domain + Vacuolar (H+)-ATPase G subunit + Protein of unknown function DUF3683 + Virus, major capsid protein, C-terminal + Mercury(II) reductase + MoaF, C-terminal domain + Histone H2A/H2B/H3 + Villin/Gelsolin + Cyclohexanecarboxyl-CoA dehydrogenase + 2-ketocyclohexanecarboxyl-CoA hydrolase + Glutamate decarboxylase + Uncharacterised protein family Ycf66 + Poly-beta-1,6 N-acetyl-D-glucosamine synthase PgaC/IcaA + Glycoside hydrolase, family 70, catalytic domain + Domain of unknown function DUF4431 + Phage tail tube protein family + Phage tail tube protein, lambda-like + Cation/H+ exchanger, CPA1 family, bacteria + Annexin repeat + Phosphatidate cytidylyltransferase, mitochondrial + Alpha-2-glucosyltransferase Alg10 + Transport accessory protein MmpS + Domain of unknown function DUF4123 + Protein of unknown function DUF4265 + Uncharacterised conserved protein withTPR-like repeats + Anti-sigma factor CnrY + IgGFc-binding protein, N-terminal + Type III secretion system, needle protein + Pullulanase, type I + Sodium/pantothenate symporter + Circadian clock protein KaiA, C-terminal + DltD + Ribosomal protein L24e, conserved site + SPARC/Testican, calcium-binding domain + Drought induced 19 protein type, zinc-binding domain + Domain of unknown function DUF4183 + Protein of unknown function DUF4184 + Peptidase M10A, cysteine switch, zinc binding site + Protein of unknown function DUF4348 + Transferase + Domain of unknown function DUF4830 + HAP1, N-terminal + Peptidase A25, germination protease + Kinetochore subunit NKP2 + Protein of unknown function DUF3227 + Immunity protein 63 + Zinc finger, PHD-type, conserved site + Ectoine dioxygenase + Ulp1 protease family, C-terminal catalytic domain + Transcription factor, choline sulphate-utilisation, putative + Sporulation initiation factor Spo0A, C-terminal + Domain of unknown function DUF1793 + Fibronectin-attachment + Domain of unknown function DUF1400 + Csa1 family + ATPase assembly factor ATP10 + KELK-motif containing domain + ShlB, POTRA domain + Peptidase S26A, superoxide dismutase maturation protease, nickel-type + Tox-URI2 domain + Transaldolase, Staphylococcus-type + PKC-activated phosphatase-1 inhibitor + YiaAB two helix + Cullin protein, neddylation domain + Anthrax toxin, edema factor, central + Protein of unknown function DUF3253 + Major facilitator superfamily, aromatic acid:H+ symporter family + GTF2I-like repeat + Replication protein + Cys-rich repeat, Myxococcales-type + CAP-associated domain + CRISPR-associated endonuclease Cas9, PAM-interacting domain + Protein of unknown function DUF3072 + Janus + Papillomavirus E2, N-terminal + Domain of unknown function DUF4101 + Probable glutamyl-tRNA(Gln) amidotransferase subunit C, archaea + 2-aminoethylphosphonate ABC transport system, permease protein, putative + DMSO reductase family, type II, chaperone + CRISPR-associated protein A791736 + Conserved hypothetical protein CHP03982 + Conserved hypothetical protein CHP03894 + Type IVb secretion, IcmS, effector-recruitment + Huwentoxin-1 family + Phosphate-starvation-induced PsiF repeat + Beta tubulin, autoregulation binding site + Domain of unknown function DUF4429 + Glycerol-3-phosphate dehydrogenase, GlpA subunit + YkvR-like domain + TonB-system energizer ExbB type-1 + Fatty acid synthase, domain 2 + Uncharacterised protein family UPF0686 + Protein of unknown function DUF1146 + Fungal dockerin domain + Herpesvirus glycoprotein J + Peptide-N-glycosidase F, N-terminal + Conjugative coupling factor TraG/TraD, PFGI-1 + Exosortase, archaea + TerB-C domain + Domain of unknown function DUF3197 + Glucosyl transferase II + Protein of unknown function DUF4337 + Cytochrome c oxidase subunit IV, actinobacteria + DpnD/PcfM-like protein + YwiC-like protein + Protein of unknown function DUF2680 + Profilin + TSC-22 / Dip / Bun + Squalene hopene cyclase + Type II restriction endonuclease SinI + Ubiquitin fusion degradation protein Ufd1-like + Cytochrome c oxidase cbb3-type, CcoQ + Anaerobic dimethyl sulphoxide reductase, subunit A, DmsA/YnfE + HofP protein + Bacteriophage T7, Gp17.5, holin + Alpha-mannosyltransferase + Pseudo-rSAM protein, GG-Bacteroidales system + Sporulation protein YabP + XK-related protein + RNA polymerase sigma-E type + Sporulation stage IV, protein A + Post-transcriptional regulator + DNA phosphorothioation system restriction enzyme, putative + Protein of unknown function DUF3093 + TonB-dependent vitamin B12 transporter BtuB + Molybdopterin synthase sulfurylase MoeB + P-aminobenzoate N-oxygenase AurF + Anti-sigma F factor antagonist + Protein of unknown function DUF3496 + Asparagine synthase family amidotransferase + tRNA (uracil-O(2)-)-methyltransferase + Peridinin-chlorophyll A binding protein + Lipase/vitellogenin + Photosystem I PsaE, reaction centre subunit IV + Protein of unknown function DUF2735 + Polynucleotide kinase-phosphatase, ligase domain + Photosystem II cytochrome b559, conserved site + Xyloglucan fucosyltransferase + HMW kininogen + Lyase, catalytic + NE1680-like domain + Tox-PL-2 domain + Tox-MPTase3 domain + Protein of unknown function DUF2105, membrane + Protein of unknown function DUF2108, membrane + Protein of unknown function DUF2109, membrane + Sporulation lipoprotein YhcN/YlaJ-like + Spore cortex biosynthesis protein, YabQ-like + Transcription elongation factor S-II, central domain + Domain of unknown function DUF3972 + Thiamine kinase + Protein of unknown function DUF3787 + Lipoxygenase, domain 3 + Protein of unknown function DUF5363 + Uncharacterised protein family Ycf55 + PDZ-like domain + PPC89 centrosome localisation domain + Sialidase, N-terminal + Sphingolipid delta4-desaturase, N-terminal + Glutathione S-transferases, subfamily 4, C-terminal + Integrating conjugative element protein, PFL4705 + Integrating conjugative element protein, PFL4711 + AIR synthase-related protein, sll0787 family + Adenosine/AMP deaminase N-terminal + Periplasmic lysozyme inhibitor, I-type + Soil-associated protein DUF3738 + Pili assembly chaperone, bacterial + ESX-1 secretion-associated protein EspC + Alpha trans-inducing protein (Alpha-TIF) + CamS sex pheromone cAM373 + Tryptophan transporter TrpP + Phosphoribosyl-dephospho-CoA transferase + PRTase ComF-like + ParB-related, ThiF-related cassette, protein E + Lunapark domain + Protein of unknown function DUF2301 + Mediator complex, subunit Med29, metazoa + Nuclear protein DGCR14 + Tryptophanase + Phosphonate utilization transcriptional regulator PhnR + Alpha-2,8-polysialyltransferase + Protein of unknown function DUF1493 + Domain of unknown function DUF1868 + P-type conjugative transfer protein VirB9 + Bacterial exotoxin B + Protein of unknown function DUF4259 + 6-carboxyhexanoate--CoA ligase + Transmembrane Fragile-X-F-associated protein + Cellulose biosynthesis, BcsF/YhjT + Protein of unknown function DUF2101, membrane + DNA-directed RNA polymerase subunit beta/EpuA + Putative RNA polymerase (calciviral)/capsid protein + Trehalose synthase/probable maltokinase, C-terminal domain + Uncharacterised membrane protein Ta0354, soluble domain + Protein of unknown function DUF3196 + Peptidase family A1 domain + Domain of unknown function DUF4781 + Ninjurin + Protein of unknown function DUF4278 + Egg lysin (Sperm-lysin) + Lipoprotein, type 6 + Quinohemoprotein amine dehydrogenase, beta subunit + Photosynthetic reaction centre, cytochrome c subunit + Glutaredoxin-like protein NrdH + Proteinase inhibitor I25, cystatin, conserved site + ATP-dependent RNA helicase RhlB + Putative outer membrane core complex of type IVb secretion + Transcription activator CII + Galactosyltransferase, N-terminal + YyzF-like protein + Domain of unknown function, DUF3672 + Fibronectin, type II, collagen-binding + Channel forming colicin, C-terminal cytotoxic + SAGA complex, Sgf11 subunit + Protein of unknown function DUF2673 + Thiostrepton-resistance methylase, N-terminal + Protein of unknown function DUF4902 + Protein of unknown function DUF1450 + Domain of unknown function DUF4955 + AIG1-type guanine nucleotide-binding (G) domain + At2g17340, N-terminal + Protein of unknown function DUF3789 + NDP-hexose 2,3-dehydratase + Protein of unknown function DUF2076 + Membrane protein of 12 TMs + Uncharacterised protein family CHP04562 + Transcriptional repressor of class III stress genes + Domain of unknown function DUF1736 + NAD(P)H-quinone oxidoreductase subunit O + Glycine N-acyltransferase, C-terminal + Mitochondrial glycoprotein + Conserved hypothetical protein CHP03084 + Acid ceramidase, N-terminal + Putative stage IV sporulation YqfD + Protein of unknown function DUF1273 + LRR-containing bacterial E3 ligase, N-terminal + Conserved oligomeric Golgi complex subunit 8 + YopX-like domain, N-terminal + Protein of unknown function DUF2605 + Bacteriophage T4, P15K, RNA polymerase binding + CRISPR-associated protein Cas1, MYXAN subtype + Glucose-6-phosphate dehydrogenase assembly protein OpcA + L-asparaginase, type II + Ta0938 + Plectin repeat + Protein of unknown function DUF1688 + Copper amine oxidase, N3-terminal + Copper amine oxidase, N2-terminal + Mannosyltransferase, DXD + Protein of unknown function DUF2633 + Sulfocyanin + Cysteine desulfurase, sulphur acceptor subunit CsdE + CRISPR-associated protein Csx3 + Bacterial phospholipase C, phosphocholine-specific + Type III secretion system regulator, LcrR + Type III secretion regulator, YopN/LcrE/InvE/MxiC + Type III secretion system chaperone, YscW + Uncharacterised protein family Ycf23 + Phycobilisome degradation protein NblA + Arv1 protein + Domain of unknown function DUF4964 + Hydroxymethylglutaryl-CoA synthase, prokaryotic + SbmA/BacA-like + RNA polymerase sigma-24-related + CLASP N-terminal domain + Protein of unknown function DUF1931 + Domain X + Flagellar transcriptional activator FlhD + Protein of unknown function DUF2181 + Dense granule Gra6 protein + mRNA capping enzyme, catalytic domain + E6 early regulatory protein + Glycosyl transferase, family 48 + Putative site-specific recombinase Gcr + Protein of unknown function DUF726 + Fanconi anemia group M protein, MHF binding domain + Protein of unknown function DUF4844 + Hyaluronidase + Predicted HAD-superfamily phosphatase, subfamily IA/Epoxide hydrolase, N-terminal + Paired domain + Type III secretion system effector YopR + Domain of unknown function DUF4422 + Thrombospondin, C-terminal + Protein of unknown function DUF3605 + Protein of unknown function DUF3606 + TUG ubiquitin-like domain + Copper amine oxidase, C-terminal + Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding + Germin + S-adenosylmethionine decarboxylase, conserved site + DMSO reductase family, type II, iron-sulphur subunit + Auxin-binding protein + 7-carboxy-7-deazaguanine synthase + Alcohol dehydrogenase, phosphonate catabolism-associated, putative + Trimethylamine-N-oxide reductase TorA + Replication factor A protein 3 + Sporulation stage V, protein T + Uncharacterised protein YhfZ, C-terminal domain + Domain of unknown function, CHP04279 + Cellulose synthase, subunit C + Ribosomal protein L14e domain + Protein of unknown function DUF2167, membrane + Protein of unknown function DUF2173 + Protein GAPT + GDP-fucose protein O-fucosyltransferase + Restriction endonuclease, type II, PvuII + Pumilio RNA-binding repeat + Protein of unknown function DUF723 + L1 transposable element, dsRBD-like domain + Protein of unknown function DUF2631 + Partial AB-hydrolase lipase domain + Protein of unknown function DUF4852 + Gonadotropin, beta subunit, conserved site + Nitrogenase alpha chain + Zinc finger, CCCH-type, TRM13 + Acyl-CoA oxidase, C-terminal + Pentaxin, conserved site + Tetracycline transcriptional regulator, TetR + Sec7 domain + Entry exclusion lipoprotein TrbK + Coenzyme F420 hydrogenase, subunit gamma + A-factor biosynthesis hotdog domain + Clostridium phage holin + Protein of unknown function DUF5414 + Peptidase aspartic, putative + Protein of unknown function DUF1517 + Protein of unknown function DUF4121 + Carboxypeptidase M99, beta-barrel domain + Protein of unknown function DUF4267 + Domain of unknown function DUF4274 + PiggyBac transposable element-derived protein + DnaJ-like protein C11, C-terminal + Phosphonate utilization associated transmembrane protein, putative + Coenzyme F390 synthetase + Protein of unknown function DUF2469 + Life-span regulatory factor + Arylsulfotransferase, Ig-like domain + Thiol-activated cytolysin C-terminal + Antiactivator protein ExsD + 5-methylthioadenosine/S-adenosylhomocysteine nucleosidase, putative + 47.0 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + 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+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + 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+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + From 2b02f66f0c6ddb4bf585c6d01c1c3525d484cc47 Mon Sep 17 00:00:00 2001 From: sandyr Date: Fri, 20 Oct 2023 18:11:26 +0100 Subject: [PATCH 02/24] fixes podman compatibility of docker setup --- .dockerignore | 30 ++++++++++++++++++++++++++++++ 1 file changed, 30 insertions(+) create mode 100644 .dockerignore diff --git a/.dockerignore b/.dockerignore new file mode 100644 index 000000000..bbd25333e --- /dev/null +++ b/.dockerignore @@ -0,0 +1,30 @@ +.DS_Store +db.sqlite3 +__pycache__ +*.pyc +var +dist +.eggs +emgcli.egg-info/ +.pytest_cache/ + +staticfiles/ +media/ +venv/ +database/ +results/ +fixtures/*.sig + +.vscode/ + +# IntelliJ project structure files +*.iml +.idea/ + +.coverage +/build/ + +loglockdir +logs + +secret.key \ No newline at end of file From 974371f9a2010b59d40fb9c1144366dcce52d359 Mon Sep 17 00:00:00 2001 From: sandyr Date: Fri, 20 Oct 2023 18:14:33 +0100 Subject: [PATCH 03/24] adds incremental ebi search dumping for analysisjobs --- .gitignore | 4 +- emgapi/migrations/0012_auto_20231020_1525.py | 23 ++++ emgapi/models.py | 66 ++++++++- .../templates/ebi_search/analyses-deletes.xml | 8 ++ emgapi/templates/ebi_search/analyses.xml | 8 ++ emgapi/templates/ebi_search/analysis.xml | 127 +++++++++--------- emgapi/templatetags/ebi_search_dump.py | 19 +++ 7 files changed, 189 insertions(+), 66 deletions(-) create mode 100644 emgapi/migrations/0012_auto_20231020_1525.py create mode 100644 emgapi/templates/ebi_search/analyses-deletes.xml create mode 100644 emgapi/templates/ebi_search/analyses.xml create mode 100644 emgapi/templatetags/ebi_search_dump.py diff --git a/.gitignore b/.gitignore index bbd25333e..583ebfecf 100644 --- a/.gitignore +++ b/.gitignore @@ -27,4 +27,6 @@ fixtures/*.sig loglockdir logs -secret.key \ No newline at end of file +secret.key + +dumps \ No newline at end of file diff --git a/emgapi/migrations/0012_auto_20231020_1525.py b/emgapi/migrations/0012_auto_20231020_1525.py new file mode 100644 index 000000000..296ffd821 --- /dev/null +++ b/emgapi/migrations/0012_auto_20231020_1525.py @@ -0,0 +1,23 @@ +# Generated by Django 3.2.18 on 2023-10-20 15:25 + +from django.db import migrations, models + + +class Migration(migrations.Migration): + + dependencies = [ + ('emgapi', '0011_analysisjob_analysis_summary_json'), + ] + + operations = [ + migrations.AddField( + model_name='analysisjob', + name='last_indexed', + field=models.DateTimeField(blank=True, db_column='LAST_INDEXED', help_text='Date at which this model was last included in an EBI Search initial/incremental index.', null=True), + ), + migrations.AddField( + model_name='analysisjob', + name='last_update', + field=models.DateTimeField(auto_now=True, db_column='LAST_UPDATE'), + ), + ] diff --git a/emgapi/models.py b/emgapi/models.py index 1faf824ea..7bb4e7a28 100644 --- a/emgapi/models.py +++ b/emgapi/models.py @@ -17,9 +17,10 @@ import logging from django.conf import settings +from django.core.exceptions import FieldDoesNotExist from django.db import models from django.db.models import (CharField, Count, OuterRef, Prefetch, Q, - Subquery, Value) + Subquery, Value, F) from django.db.models.functions import Cast, Concat from django.utils import timezone @@ -160,6 +161,67 @@ class Meta: abstract = True +class EbiSearchIndexQueryset(models.QuerySet): + """ + to_delete: Objects that have been suppressed since they were last indexed, + or that have been indexed but updated since. + + to_add: Objects that have never been indexed, + or that have been indexed but updated since. + """ + def to_delete(self): + updated_after_indexing = Q(last_update__gte=F("last_indexed"), last_indexed__isnull=False) + + try: + self.model._meta.get_field("suppressed_at") + except FieldDoesNotExist: + return self.filter( + updated_after_indexing + ) + else: + return self.filter( + Q(suppressed_at__gte=F("last_indexed")) | updated_after_indexing + ) + + def to_add(self): + updated_after_indexing = Q(last_update__gte=F("last_indexed"), last_indexed__isnull=False) + never_indexed = Q(last_indexed__isnull=True) + + try: + self.model._meta.get_field("is_suppressed") + except FieldDoesNotExist: + not_suppressed = Q() + else: + not_suppressed = Q(is_suppressed=False) + + try: + self.model._meta.get_field("is_private") + except FieldDoesNotExist: + not_private = Q() + else: + not_private = Q(is_private=False) + + return self.filter(never_indexed | updated_after_indexing, not_suppressed, not_private) + + +class EbiSearchIndexedModel(models.Model): + last_update = models.DateTimeField( + db_column='LAST_UPDATE', + auto_now=True + ) + last_indexed = models.DateTimeField( + db_column='LAST_INDEXED', + null=True, + blank=True, + help_text="Date at which this model was last included in an EBI Search initial/incremental index." + ) + + objects_for_indexing = EbiSearchIndexQueryset.as_manager() + + class Meta: + abstract = True + + class BaseQuerySet(models.QuerySet): """Auth mechanism to filter private / suppressed models """ @@ -1538,7 +1600,7 @@ def available(self, request): ) -class AnalysisJob(SuppressibleModel, PrivacyControlledModel): +class AnalysisJob(SuppressibleModel, PrivacyControlledModel, EbiSearchIndexedModel): def __init__(self, *args, **kwargs): super(AnalysisJob, self).__init__(*args, **kwargs) setattr(self, 'accession', diff --git a/emgapi/templates/ebi_search/analyses-deletes.xml b/emgapi/templates/ebi_search/analyses-deletes.xml new file mode 100644 index 000000000..a8ae25841 --- /dev/null +++ b/emgapi/templates/ebi_search/analyses-deletes.xml @@ -0,0 +1,8 @@ + + EMG_run + + {% for entry in removals %} + + {% endfor %} + + diff --git a/emgapi/templates/ebi_search/analyses.xml b/emgapi/templates/ebi_search/analyses.xml new file mode 100644 index 000000000..90cf547e1 --- /dev/null +++ b/emgapi/templates/ebi_search/analyses.xml @@ -0,0 +1,8 @@ + + EMG_run + + {% for a in additions %} + {% include "ebi_search/analysis.xml" with analysis=a.analysis analysis_biome=a.analysis_biome analysis_taxonomies=a.analysis_taxonomies analysis_go_entries=a.analysis_go_entries analysis_ips_entries=a.analysis_ips_entries sample_metadata=a.sample_metadata only %} + {% endfor %} + + diff --git a/emgapi/templates/ebi_search/analysis.xml b/emgapi/templates/ebi_search/analysis.xml index dd06c1c95..ac1bc101a 100644 --- a/emgapi/templates/ebi_search/analysis.xml +++ b/emgapi/templates/ebi_search/analysis.xml @@ -1,69 +1,70 @@ - - {{ analysis.accession }} - - - - - - assembly - {{ analysis.pipeline.release_version }} - {{ analysis.sample.sample_name }} - {{ analysis.study.study_name }} - {{ analysis.study.biome.biome_name }} - - {% for biome_element in analysis_biome %} - {% if forloop.first %} - {{ biome_element }} - {% else %} - {{ biome_element }} - {% endif %} - {% endfor %} - - {% for taxonomy_lineage_elements in analysis_taxonomies %} - - {% for taxonomy_element in taxonomy_lineage_elements %} - {% if forloop.first %} - {{ taxonomy_element }} - {% else %} - {{ taxonomy_element }} - {% endif %} - {% endfor %} - - {% endfor %} - {% for go_slim in analysis_go_slim_entries %} - {{ go_slim.description }} - {% endfor %} + + {{ analysis.accession }} + + + + + + assembly + {{ analysis.pipeline.release_version }} + {{ analysis.sample.sample_name | safe }} + {{ analysis.study.study_name | safe }} + {{ analysis.study.biome.biome_name | safe }} + + {% for biome_element in analysis_biome %} + {% if forloop.first %} + {{ biome_element | safe }} + {% else %} + {{ biome_element | safe }} + {% endif %} + {% endfor %} + + {% for taxonomy_lineage_elements in analysis_taxonomies %} + + {% for taxonomy_element in taxonomy_lineage_elements %} + {% if forloop.first %} + {{ taxonomy_element | safe }} + {% else %} + {{ taxonomy_element | safe }} + {% endif %} + {% endfor %} + + {% endfor %} + + {% for go_slim in analysis_go_entries %} + {{ go_slim.description | safe }} + {% endfor %} - {% for ips in analysis_ips_entries %} - {{ ips.description }} - {% endfor %} + {% for ips in analysis_ips_entries %} + {{ ips.description | safe }} + {% endfor %} - {% for metadata_key, metadata_value in sample_metadata.items %} - {{ metadata_value }} - {% endfor %} + {% for metadata_key, metadata_value in sample_metadata.items %} + {{ metadata_value | safe }} + {% endfor %} - - - - - + + + + + - {# Assembly analysis #} - {% if analysis.assembly and analysis.assembly.accession|slice:":4" == "GCA_" %} - - - {% endif %} + {# Assembly analysis #} + {% if analysis.assembly and analysis.assembly.accession|slice:":4" == "GCA_" %} + + + {% endif %} - {# WGS/Amplicon analysis #} - {% if analysis.run %} - - {% endif %} - {% for go in analysis_go_entries %} - - {% endfor %} - {% for ips in analysis_ips_entries %} - - {% endfor %} - - \ No newline at end of file + {# WGS/Amplicon analysis #} + {% if analysis.run %} + + {% endif %} + {% for go in analysis_go_entries %} + + {% endfor %} + {% for ips in analysis_ips_entries %} + + {% endfor %} + + \ No newline at end of file diff --git a/emgapi/templatetags/ebi_search_dump.py b/emgapi/templatetags/ebi_search_dump.py new file mode 100644 index 000000000..5480e4eee --- /dev/null +++ b/emgapi/templatetags/ebi_search_dump.py @@ -0,0 +1,19 @@ +from django import template + +register = template.Library() + + +@register.simple_tag +def xml_safe(unsafe_string: str): + if not unsafe_string: + return None + + replacements = str.maketrans({ + "<": "<", + ">": ">", + "&": "&", + "'": "'", + '"': """, + }) + + return unsafe_string.translate(replacements) From 14f0842d0bc740e29fc8c5430067e36b540089bb Mon Sep 17 00:00:00 2001 From: sandyr Date: Mon, 23 Oct 2023 16:47:44 +0100 Subject: [PATCH 04/24] integrates indexable sample data into analyses ebi search dump --- .../commands/ebi_search_analysis_dump.py | 184 ++++++++++-------- emgapi/templates/ebi_search/analysis.xml | 28 ++- emgapi/templatetags/ebi_search_dump.py | 19 -- 3 files changed, 124 insertions(+), 107 deletions(-) delete mode 100644 emgapi/templatetags/ebi_search_dump.py diff --git a/emgapi/management/commands/ebi_search_analysis_dump.py b/emgapi/management/commands/ebi_search_analysis_dump.py index 773f80feb..0e447db10 100644 --- a/emgapi/management/commands/ebi_search_analysis_dump.py +++ b/emgapi/management/commands/ebi_search_analysis_dump.py @@ -15,10 +15,13 @@ # limitations under the License. import logging -import re +import pathlib +from datetime import timedelta from django.core.management import BaseCommand +from django.db.models import QuerySet from django.template.loader import render_to_string +from django.utils import timezone from emgapi.models import AnalysisJob from emgapianns.models import ( @@ -31,50 +34,18 @@ class Command(BaseCommand): - help = "Generate the XML dump of an analysis." + help = "Generate the XML dump of analyses for EBI Search." def add_arguments(self, parser): super(Command, self).add_arguments(parser) parser.add_argument( - "-a", "--accession", help="Analysis accession", required=True + "--full", + action="store_true", + help="Create a full snapshot rather than incremental.", ) - parser.add_argument("-o", "--output", help="Output xml file", required=True) - - # TODO: this was ported directly from EBI Search Dump - # we need to improve it, maybe move it to a template tag? - # TODO: apply this to InterPro and GO annotations - def unicode_and_clean(self, identifier, text): - """Converts text to utf8 encoded string with xml subsitutions""" - if not text: - return text - try: - text = text.encode("utf8", "strict") - except Exception as ex: - match = re.search(r"in position (\d+)", str(ex)) - if match: - position = int(match.group(1)) - matchStart = position - 15 - if matchStart < 0: - matchStart = 0 - matchEnd = position + 15 - if matchEnd > len(text): - matchEnd = len(text) - logger.error( - f"Replacing '{identifier}' in {text[position]} [{text[matchStart:matchEnd]}]", - ex, - ) - text = text[:position] + text[position + 1 :] - text = self.unicode_and_clean(identifier, text) - else: - logger.error(f"Failed to convert: {identifier}.", ex) - return text.decode("utf8") + parser.add_argument("-o", "--output", help="Output dir for xml files", required=True) - def handle(self, *args, **options): - """Render an analysis using the EBI Search XML template""" - # TODO: The migration for the analysis should be nearly done, code ported from: https://github.com/EBI-Metagenomics/MetagenomicsSearchDump - # In that repo the analyses corresponds to the Run entries. - accession: str = options["accession"] - analysis: AnalysisJob = AnalysisJob.objects.get(job_id=accession) + def get_analysis_context(self, analysis: AnalysisJob): analysis_taxonomy: AnalysisJobTaxonomy = AnalysisJobTaxonomy.objects.get( analysis_id=str(analysis.job_id) ) @@ -101,36 +72,10 @@ def handle(self, *args, **options): tax_lineage_list = list(filter(None, tax.lineage.split(":"))) if len(tax_lineage_list) > 1: taxonomy_lists.append( - [ - self.unicode_and_clean("tax", tax_el) - for tax_el in tax_lineage_list - ] + tax_lineage_list ) - # TODO: port these metadata "cleaning" rules. - # if depth and len(depth) > 0: - # self.depth = checkIfNumerical(extID, depth) - # if altitude and len(altitude) > 0: - # self.altitude = checkIfNumerical(extID, altitude) - # if elevation and len(elevation) > 0: - # self.elevation = checkIfNumerical(extID, elevation) - # if salinity and len(salinity) > 0: - # self.salinity = checkIfNumerical(extID, salinity) - # if temperature and len(temperature) > 0: - # self.temperature = checkIfNumerical(extID, temperature) - # if pH and len(pH) > 0: - # self.pH = checkIfNumerical(extID, pH[0]) - # if longitudeStart and len(longitudeStart) > 0: - # self.longitudeStart = encodeToUnicodeAndClean(extID, longitudeStart) - # if longitudeEnd and len(longitudeEnd) > 0: - # self.longitudeEnd = checkIfNumerical(extID, longitudeEnd) - # if latitudeStart and len(latitudeStart) > 0: - # self.latitudeStart = checkIfNumerical(extID, latitudeStart) - # if latitudeEnd and len(latitudeEnd) > 0: - # self.latitudeEnd = checkIfNumerical(extID, latitudeEnd) - - # TODO: from this list (taken from ) - SAMPLE_ANNOTATIONS_ACCEPT_LIST = { + sample_numeric_fields_to_index = { "temperature": "temperature", "pH": "pH", "altitude": "altitude", @@ -145,23 +90,98 @@ def handle(self, *args, **options): "latitude end": "latitudeEnd", } + sample_text_annotations_to_index = { + "sequencing method": "sequencing_method", + "geographic location (region and locality)": "location_name", + "geographic location (country and/or sea,region)": "location_name", + "disease status": "disease_status", + "phenotype": "phenotype", + } + + sample_annotations_to_index = sample_numeric_fields_to_index.copy() + sample_annotations_to_index.update(sample_text_annotations_to_index) + sample_metadata = {} for sample_metadata_entry in analysis.sample.metadata.all(): - if sample_metadata_entry.var.var_name in SAMPLE_ANNOTATIONS_ACCEPT_LIST: + if (vn := sample_metadata_entry.var.var_name) in sample_annotations_to_index: + indexable_name = sample_annotations_to_index[vn] + indexable_value = sample_metadata_entry.var_val_ucv + + if indexable_name in sample_numeric_fields_to_index.values(): + try: + indexable_value = float(indexable_value.strip()) + except ValueError: + logger.warning( + f"Could not float-parse supposedly numeric field {indexable_name} : {indexable_value}") + continue sample_metadata[ - SAMPLE_ANNOTATIONS_ACCEPT_LIST[sample_metadata_entry.var.var_name] - ] = sample_metadata_entry.var_val_ucv - - print( - render_to_string( - "ebi_search/analysis.xml", - { - "analysis": analysis, - "analysis_biome": biome_list, - "analysis_taxonomies": taxonomy_lists, - "analysis_go_entries": go_annotation.go_terms, - "analysis_ips_entries": ips_annotation.interpro_identifiers, - "sample_metadata": sample_metadata, - }, + indexable_name + ] = indexable_value + + if 'location_name' not in sample_metadata and analysis.sample.geo_loc_name: + sample_metadata['location_name'] = analysis.sample.geo_loc_name + + return { + "analysis": analysis, + "analysis_biome": biome_list, + "analysis_taxonomies": taxonomy_lists, + "analysis_go_entries": go_annotation.go_terms, + "analysis_ips_entries": ips_annotation.interpro_identifiers, + "sample_metadata": sample_metadata, + } + + @staticmethod + def write_without_blank_lines(fp, string): + fp.write( + "\n".join( + filter( + str.strip, + string.splitlines() + ) ) ) + + def handle(self, *args, **options): + """Dump EBI Search XML file of analyses""" + is_full_snapshot: str = options["full"] + output_dir: str = options["output"] + + pathlib.Path(output_dir).mkdir(parents=True, exist_ok=True) + + analyses: QuerySet = AnalysisJob.objects.available(None) + + if not is_full_snapshot: + analyses = AnalysisJob.objects_for_indexing.to_add() + + removals = AnalysisJob.objects_for_indexing.to_delete() + + # produce incremental deletion file + deletions_file = pathlib.Path(output_dir) / pathlib.Path('analyses-deletes.xml') + with open(deletions_file, 'w') as d: + self.write_without_blank_lines(d, + render_to_string( + "ebi_search/analyses-deletes.xml", + { + "removals": removals + } + ) + ) + + additions_file = pathlib.Path(output_dir) / pathlib.Path('analyses.xml') + with open(additions_file, 'w') as a: + self.write_without_blank_lines(a, + render_to_string( + "ebi_search/analyses.xml", + { + "additions": (self.get_analysis_context(analysis) for analysis in analyses) + } + ) + ) + + nowish = timezone.now() + timedelta(minutes=1) + # Small buffer into the future so that the indexing time remains ahead of auto-now updated times. + + for analysis in analyses: + analysis.last_indexed = nowish + + AnalysisJob.objects.bulk_update(analyses, fields=["last_indexed"]) diff --git a/emgapi/templates/ebi_search/analysis.xml b/emgapi/templates/ebi_search/analysis.xml index ac1bc101a..841c2c079 100644 --- a/emgapi/templates/ebi_search/analysis.xml +++ b/emgapi/templates/ebi_search/analysis.xml @@ -4,6 +4,7 @@ + assembly @@ -11,6 +12,22 @@ {{ analysis.sample.sample_name | safe }} {{ analysis.study.study_name | safe }} {{ analysis.study.biome.biome_name | safe }} + + {% if analysis.sample.species %} + {{ analysis.sample.species | safe }} + {% endif %} + + {% if analysis.sample.environment_feature %} + {{ analysis.sample.environment_feature | safe }} + {% endif %} + + {% if analysis.sample.environment_material %} + {{ analysis.sample.environment_material | safe }} + {% endif %} + + {{ analysis.sample.sample_alias | safe }} + {{ analysis.study.study_name | safe }} + {% for biome_element in analysis_biome %} {% if forloop.first %} @@ -20,6 +37,11 @@ {% endif %} {% endfor %} + + {% for metadata_key, metadata_value in sample_metadata.items %} + {{ metadata_value | safe }} + {% endfor %} + {% for taxonomy_lineage_elements in analysis_taxonomies %} {% for taxonomy_element in taxonomy_lineage_elements %} @@ -39,14 +61,8 @@ {% for ips in analysis_ips_entries %} {{ ips.description | safe }} {% endfor %} - - {% for metadata_key, metadata_value in sample_metadata.items %} - {{ metadata_value | safe }} - {% endfor %} - - diff --git a/emgapi/templatetags/ebi_search_dump.py b/emgapi/templatetags/ebi_search_dump.py deleted file mode 100644 index 5480e4eee..000000000 --- a/emgapi/templatetags/ebi_search_dump.py +++ /dev/null @@ -1,19 +0,0 @@ -from django import template - -register = template.Library() - - -@register.simple_tag -def xml_safe(unsafe_string: str): - if not unsafe_string: - return None - - replacements = str.maketrans({ - "<": "<", - ">": ">", - "&": "&", - "'": "'", - '"': """, - }) - - return unsafe_string.translate(replacements) From 1a3acfdfb81a6004f1851a272e2b824a1a5189ed Mon Sep 17 00:00:00 2001 From: sandyr Date: Tue, 24 Oct 2023 15:45:07 +0100 Subject: [PATCH 05/24] adds ebi search dump for studies/projects (plus some tweaks to analyses) --- .../commands/ebi_search_analysis_dump.py | 3 +- .../commands/ebi_search_study_dump.py | 108 ++++++++++++++++++ emgapi/migrations/0013_study_last_indexed.py | 18 +++ .../0014_alter_study_last_update.py | 18 +++ emgapi/models.py | 4 +- emgapi/templates/ebi_search/analyses.xml | 3 + .../templates/ebi_search/projects-deletes.xml | 8 ++ emgapi/templates/ebi_search/projects.xml | 40 +++++++ 8 files changed, 199 insertions(+), 3 deletions(-) create mode 100644 emgapi/management/commands/ebi_search_study_dump.py create mode 100644 emgapi/migrations/0013_study_last_indexed.py create mode 100644 emgapi/migrations/0014_alter_study_last_update.py create mode 100644 emgapi/templates/ebi_search/projects-deletes.xml create mode 100644 emgapi/templates/ebi_search/projects.xml diff --git a/emgapi/management/commands/ebi_search_analysis_dump.py b/emgapi/management/commands/ebi_search_analysis_dump.py index 0e447db10..6a079e1d3 100644 --- a/emgapi/management/commands/ebi_search_analysis_dump.py +++ b/emgapi/management/commands/ebi_search_analysis_dump.py @@ -173,7 +173,8 @@ def handle(self, *args, **options): render_to_string( "ebi_search/analyses.xml", { - "additions": (self.get_analysis_context(analysis) for analysis in analyses) + "additions": (self.get_analysis_context(analysis) for analysis in analyses), + "count": analyses.count() } ) ) diff --git a/emgapi/management/commands/ebi_search_study_dump.py b/emgapi/management/commands/ebi_search_study_dump.py new file mode 100644 index 000000000..1bee1aa08 --- /dev/null +++ b/emgapi/management/commands/ebi_search_study_dump.py @@ -0,0 +1,108 @@ +#!/usr/bin/env python +# -*- coding: utf-8 -*- + +# Copyright 2017-2023 EMBL - European Bioinformatics Institute +# +# Licensed under the Apache License, Version 2.0 (the "License"); +# you may not use this file except in compliance with the License. +# You may obtain a copy of the License at +# http://www.apache.org/licenses/LICENSE-2.0 +# +# Unless required by applicable law or agreed to in writing, software +# distributed under the License is distributed on an "AS IS" BASIS, +# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. +# See the License for the specific language governing permissions and +# limitations under the License. + +import logging +import pathlib +from datetime import timedelta + +from django.core.management import BaseCommand +from django.db.models import QuerySet +from django.template.loader import render_to_string +from django.utils import timezone + +from emgapi.models import Study + +logger = logging.getLogger(__name__) + + +class Command(BaseCommand): + help = "Generate the XML dump of studies for EBI Search." + + def add_arguments(self, parser): + super(Command, self).add_arguments(parser) + parser.add_argument( + "--full", + action="store_true", + help="Create a full snapshot rather than incremental.", + ) + parser.add_argument("-o", "--output", help="Output dir for xml files", required=True) + + + @staticmethod + def write_without_blank_lines(fp, string): + fp.write( + "\n".join( + filter( + str.strip, + string.splitlines() + ) + ) + ) + + @staticmethod + def get_study_context(study: Study): + biome_list = study.biome.lineage.split(":")[1:] + + return { + "study": study, + "biome_list": biome_list + } + + def handle(self, *args, **options): + """Dump EBI Search XML file of studies/projects""" + is_full_snapshot: str = options["full"] + output_dir: str = options["output"] + + pathlib.Path(output_dir).mkdir(parents=True, exist_ok=True) + + studies: QuerySet = Study.objects.available(None) + + if not is_full_snapshot: + studies = Study.objects_for_indexing.to_add() + + removals = Study.objects_for_indexing.to_delete() + + # produce incremental deletion file + deletions_file = pathlib.Path(output_dir) / pathlib.Path('projects-deletes.xml') + with open(deletions_file, 'w') as d: + self.write_without_blank_lines(d, + render_to_string( + "ebi_search/projects-deletes.xml", + { + "removals": removals + } + ) + ) + + additions_file = pathlib.Path(output_dir) / pathlib.Path('projects.xml') + with open(additions_file, 'w') as a: + self.write_without_blank_lines(a, + render_to_string( + "ebi_search/projects.xml", + { + "additions": (self.get_study_context(study) for study in studies), + "count": studies.count() + } + ) + ) + + nowish = timezone.now() + timedelta(minutes=1) + # Small buffer into the future so that the indexing time remains ahead of auto-now updated times. + + for study in studies: + study.last_indexed = nowish + + Study.objects.bulk_update(studies, fields=["last_indexed"]) diff --git a/emgapi/migrations/0013_study_last_indexed.py b/emgapi/migrations/0013_study_last_indexed.py new file mode 100644 index 000000000..e141ee7fd --- /dev/null +++ b/emgapi/migrations/0013_study_last_indexed.py @@ -0,0 +1,18 @@ +# Generated by Django 3.2.18 on 2023-10-23 16:41 + +from django.db import migrations, models + + +class Migration(migrations.Migration): + + dependencies = [ + ('emgapi', '0012_auto_20231020_1525'), + ] + + operations = [ + migrations.AddField( + model_name='study', + name='last_indexed', + field=models.DateTimeField(blank=True, db_column='LAST_INDEXED', help_text='Date at which this model was last included in an EBI Search initial/incremental index.', null=True), + ), + ] diff --git a/emgapi/migrations/0014_alter_study_last_update.py b/emgapi/migrations/0014_alter_study_last_update.py new file mode 100644 index 000000000..4eb998c33 --- /dev/null +++ b/emgapi/migrations/0014_alter_study_last_update.py @@ -0,0 +1,18 @@ +# Generated by Django 3.2.18 on 2023-10-23 17:16 + +from django.db import migrations, models + + +class Migration(migrations.Migration): + + dependencies = [ + ('emgapi', '0013_study_last_indexed'), + ] + + operations = [ + migrations.AlterField( + model_name='study', + name='last_update', + field=models.DateTimeField(auto_now=True, db_column='LAST_UPDATE'), + ), + ] diff --git a/emgapi/models.py b/emgapi/models.py index 7bb4e7a28..8379497d6 100644 --- a/emgapi/models.py +++ b/emgapi/models.py @@ -893,7 +893,7 @@ def mydata(self, request): return self.get_queryset().mydata(request) -class Study(ENASyncableModel): +class Study(ENASyncableModel, EbiSearchIndexedModel): def __init__(self, *args, **kwargs): super(Study, self).__init__(*args, **kwargs) @@ -927,7 +927,7 @@ def _custom_pk(self): author_name = models.CharField( db_column='AUTHOR_NAME', max_length=100, blank=True, null=True) last_update = models.DateTimeField( - db_column='LAST_UPDATE') + db_column='LAST_UPDATE', auto_now=True) submission_account_id = models.CharField( db_column='SUBMISSION_ACCOUNT_ID', max_length=15, blank=True, null=True) diff --git a/emgapi/templates/ebi_search/analyses.xml b/emgapi/templates/ebi_search/analyses.xml index 90cf547e1..c90e395a1 100644 --- a/emgapi/templates/ebi_search/analyses.xml +++ b/emgapi/templates/ebi_search/analyses.xml @@ -1,5 +1,8 @@ EMG_run + EMG Analysis runs – samples analysed by MGnify pipelines + {% now "Y-m-d" %} + {{ count }} {% for a in additions %} {% include "ebi_search/analysis.xml" with analysis=a.analysis analysis_biome=a.analysis_biome analysis_taxonomies=a.analysis_taxonomies analysis_go_entries=a.analysis_go_entries analysis_ips_entries=a.analysis_ips_entries sample_metadata=a.sample_metadata only %} diff --git a/emgapi/templates/ebi_search/projects-deletes.xml b/emgapi/templates/ebi_search/projects-deletes.xml new file mode 100644 index 000000000..437027a75 --- /dev/null +++ b/emgapi/templates/ebi_search/projects-deletes.xml @@ -0,0 +1,8 @@ + + EMG_Project + + {% for entry in removals %} + + {% endfor %} + + diff --git a/emgapi/templates/ebi_search/projects.xml b/emgapi/templates/ebi_search/projects.xml new file mode 100644 index 000000000..d8827e4a1 --- /dev/null +++ b/emgapi/templates/ebi_search/projects.xml @@ -0,0 +1,40 @@ + + EMG_Project + EMG Projects – studies analysed by MGnify + {% now "Y-m-d" %} + {{ count }} + + {% for addition in additions %} + {% with addition.study as study %} + + {{ study.study_name | safe }} + {{ study.study_abstract | safe }} + + + + + + {{ study.secondary_accession }} + {{ study.biome.biome_name }} + + {% for biome_element in addition.biome_list %} + {% if forloop.first %} + {{ biome_element | safe }} + {% else %} + {{ biome_element | safe }} + {% endif %} + {% endfor %} + + {{ study.centre_name | safe }} + + + + {% for analysis in study.analyses.all %} + + {% endfor %} + + + {% endwith %} + {% endfor %} + + From d914ec187c15d6028caad7e2c8cb228d103149fa Mon Sep 17 00:00:00 2001 From: sandyr Date: Fri, 10 Nov 2023 13:30:02 +0000 Subject: [PATCH 06/24] resolve migration merge conflicts --- ...1020_1525.py => 0013_auto_20231110_1329.py} | 14 ++++++++++++-- emgapi/migrations/0013_study_last_indexed.py | 18 ------------------ .../migrations/0014_alter_study_last_update.py | 18 ------------------ 3 files changed, 12 insertions(+), 38 deletions(-) rename emgapi/migrations/{0012_auto_20231020_1525.py => 0013_auto_20231110_1329.py} (51%) delete mode 100644 emgapi/migrations/0013_study_last_indexed.py delete mode 100644 emgapi/migrations/0014_alter_study_last_update.py diff --git a/emgapi/migrations/0012_auto_20231020_1525.py b/emgapi/migrations/0013_auto_20231110_1329.py similarity index 51% rename from emgapi/migrations/0012_auto_20231020_1525.py rename to emgapi/migrations/0013_auto_20231110_1329.py index 296ffd821..998fc7202 100644 --- a/emgapi/migrations/0012_auto_20231020_1525.py +++ b/emgapi/migrations/0013_auto_20231110_1329.py @@ -1,4 +1,4 @@ -# Generated by Django 3.2.18 on 2023-10-20 15:25 +# Generated by Django 3.2.18 on 2023-11-10 13:29 from django.db import migrations, models @@ -6,7 +6,7 @@ class Migration(migrations.Migration): dependencies = [ - ('emgapi', '0011_analysisjob_analysis_summary_json'), + ('emgapi', '0012_alter_publication_pub_type'), ] operations = [ @@ -20,4 +20,14 @@ class Migration(migrations.Migration): name='last_update', field=models.DateTimeField(auto_now=True, db_column='LAST_UPDATE'), ), + migrations.AddField( + model_name='study', + name='last_indexed', + field=models.DateTimeField(blank=True, db_column='LAST_INDEXED', help_text='Date at which this model was last included in an EBI Search initial/incremental index.', null=True), + ), + migrations.AlterField( + model_name='study', + name='last_update', + field=models.DateTimeField(auto_now=True, db_column='LAST_UPDATE'), + ), ] diff --git a/emgapi/migrations/0013_study_last_indexed.py b/emgapi/migrations/0013_study_last_indexed.py deleted file mode 100644 index e141ee7fd..000000000 --- a/emgapi/migrations/0013_study_last_indexed.py +++ /dev/null @@ -1,18 +0,0 @@ -# Generated by Django 3.2.18 on 2023-10-23 16:41 - -from django.db import migrations, models - - -class Migration(migrations.Migration): - - dependencies = [ - ('emgapi', '0012_auto_20231020_1525'), - ] - - operations = [ - migrations.AddField( - model_name='study', - name='last_indexed', - field=models.DateTimeField(blank=True, db_column='LAST_INDEXED', help_text='Date at which this model was last included in an EBI Search initial/incremental index.', null=True), - ), - ] diff --git a/emgapi/migrations/0014_alter_study_last_update.py b/emgapi/migrations/0014_alter_study_last_update.py deleted file mode 100644 index 4eb998c33..000000000 --- a/emgapi/migrations/0014_alter_study_last_update.py +++ /dev/null @@ -1,18 +0,0 @@ -# Generated by Django 3.2.18 on 2023-10-23 17:16 - -from django.db import migrations, models - - -class Migration(migrations.Migration): - - dependencies = [ - ('emgapi', '0013_study_last_indexed'), - ] - - operations = [ - migrations.AlterField( - model_name='study', - name='last_update', - field=models.DateTimeField(auto_now=True, db_column='LAST_UPDATE'), - ), - ] From ca360e0fd770ec71d82bd0175c2598d019f5716d Mon Sep 17 00:00:00 2001 From: sandyr Date: Fri, 10 Nov 2023 16:17:20 +0000 Subject: [PATCH 07/24] v2.4.36 --- emgcli/__init__.py | 2 +- pyproject.toml | 2 +- 2 files changed, 2 insertions(+), 2 deletions(-) diff --git a/emgcli/__init__.py b/emgcli/__init__.py index 31dfb7928..d550e808a 100644 --- a/emgcli/__init__.py +++ b/emgcli/__init__.py @@ -1 +1 @@ -__version__: str = "2.4.35" +__version__: str = "2.4.36" diff --git a/pyproject.toml b/pyproject.toml index 569182588..2063ce372 100644 --- a/pyproject.toml +++ b/pyproject.toml @@ -117,7 +117,7 @@ max-line-length = 119 """ [tool.bumpversion] -current_version = "2.4.35" +current_version = "2.4.36" [[tool.bumpversion.files]] filename = "emgcli/__init__.py" From 2827c2b1698a4a5269bb4b4056cc8ea6c2b6aa89 Mon Sep 17 00:00:00 2001 From: sandyr Date: Mon, 13 Nov 2023 11:05:59 +0000 Subject: [PATCH 08/24] allows analysis features to be null in ebi search dump --- .../commands/ebi_search_analysis_dump.py | 68 ++++++++++++------- emgcli/__init__.py | 2 +- pyproject.toml | 2 +- 3 files changed, 44 insertions(+), 28 deletions(-) diff --git a/emgapi/management/commands/ebi_search_analysis_dump.py b/emgapi/management/commands/ebi_search_analysis_dump.py index 6a079e1d3..32de63491 100644 --- a/emgapi/management/commands/ebi_search_analysis_dump.py +++ b/emgapi/management/commands/ebi_search_analysis_dump.py @@ -17,6 +17,7 @@ import logging import pathlib from datetime import timedelta +from typing import Optional from django.core.management import BaseCommand from django.db.models import QuerySet @@ -46,34 +47,49 @@ def add_arguments(self, parser): parser.add_argument("-o", "--output", help="Output dir for xml files", required=True) def get_analysis_context(self, analysis: AnalysisJob): - analysis_taxonomy: AnalysisJobTaxonomy = AnalysisJobTaxonomy.objects.get( - analysis_id=str(analysis.job_id) - ) - go_annotation: AnalysisJobGoTerm = AnalysisJobGoTerm.objects.get( - pk=str(analysis.job_id) - ) - ips_annotation: AnalysisJobInterproIdentifier = AnalysisJobInterproIdentifier.objects.get( - pk=str(analysis.job_id) - ) + try: + analysis_taxonomy: Optional[AnalysisJobTaxonomy] = AnalysisJobTaxonomy.objects.get( + analysis_id=str(analysis.job_id) + ) + except AnalysisJobTaxonomy.DoesNotExist: + logger.warning(f"Could not find analysis job taxonomy for {analysis.job_id}") + analysis_taxonomy = None + + try: + go_annotation: Optional[AnalysisJobGoTerm] = AnalysisJobGoTerm.objects.get( + pk=str(analysis.job_id) + ) + except AnalysisJobGoTerm.DoesNotExist: + logger.warning(f"Could not find go terms for {analysis.job_id}") + go_annotation = None + + try: + ips_annotation: Optional[AnalysisJobInterproIdentifier] = AnalysisJobInterproIdentifier.objects.get( + pk=str(analysis.job_id) + ) + except AnalysisJobInterproIdentifier.DoesNotExist: + logger.warning(f"Could not find IPS terms for {analysis.job_id}") + ips_annotation = None biome_list = analysis.study.biome.lineage.split(":")[1:] taxonomy_lists = [] - taxonomy_attributes = [ - analysis_taxonomy.taxonomy, - analysis_taxonomy.taxonomy_ssu, - analysis_taxonomy.taxonomy_lsu, - analysis_taxonomy.taxonomy_itsonedb, - analysis_taxonomy.taxonomy_itsunite, - ] - for taxonomy_attribute in taxonomy_attributes: - if taxonomy_attribute: - for tax in taxonomy_attribute: - tax_lineage_list = list(filter(None, tax.lineage.split(":"))) - if len(tax_lineage_list) > 1: - taxonomy_lists.append( - tax_lineage_list - ) + if analysis_taxonomy: + taxonomy_attributes = [ + analysis_taxonomy.taxonomy, + analysis_taxonomy.taxonomy_ssu, + analysis_taxonomy.taxonomy_lsu, + analysis_taxonomy.taxonomy_itsonedb, + analysis_taxonomy.taxonomy_itsunite, + ] + for taxonomy_attribute in taxonomy_attributes: + if taxonomy_attribute: + for tax in taxonomy_attribute: + tax_lineage_list = list(filter(None, tax.lineage.split(":"))) + if len(tax_lineage_list) > 1: + taxonomy_lists.append( + tax_lineage_list + ) sample_numeric_fields_to_index = { "temperature": "temperature", @@ -125,8 +141,8 @@ def get_analysis_context(self, analysis: AnalysisJob): "analysis": analysis, "analysis_biome": biome_list, "analysis_taxonomies": taxonomy_lists, - "analysis_go_entries": go_annotation.go_terms, - "analysis_ips_entries": ips_annotation.interpro_identifiers, + "analysis_go_entries": go_annotation.go_terms if go_annotation else [], + "analysis_ips_entries": ips_annotation.interpro_identifiers if ips_annotation else [], "sample_metadata": sample_metadata, } diff --git a/emgcli/__init__.py b/emgcli/__init__.py index d550e808a..3d7256add 100644 --- a/emgcli/__init__.py +++ b/emgcli/__init__.py @@ -1 +1 @@ -__version__: str = "2.4.36" +__version__: str = "2.4.37" diff --git a/pyproject.toml b/pyproject.toml index 2063ce372..a78ee347e 100644 --- a/pyproject.toml +++ b/pyproject.toml @@ -117,7 +117,7 @@ max-line-length = 119 """ [tool.bumpversion] -current_version = "2.4.36" +current_version = "2.4.37" [[tool.bumpversion.files]] filename = "emgcli/__init__.py" From d18573c0efec0e486f85d95e3d1c02f0b9f2cab8 Mon Sep 17 00:00:00 2001 From: sandyr Date: Wed, 15 Nov 2023 11:28:37 +0000 Subject: [PATCH 09/24] adds support for chunking of analysis-runs ebi search dump --- .../commands/ebi_search_analysis_dump.py | 39 +++++++++++-------- emgcli/__init__.py | 2 +- pyproject.toml | 2 +- 3 files changed, 25 insertions(+), 18 deletions(-) diff --git a/emgapi/management/commands/ebi_search_analysis_dump.py b/emgapi/management/commands/ebi_search_analysis_dump.py index 32de63491..f2713f3fb 100644 --- a/emgapi/management/commands/ebi_search_analysis_dump.py +++ b/emgapi/management/commands/ebi_search_analysis_dump.py @@ -20,6 +20,7 @@ from typing import Optional from django.core.management import BaseCommand +from django.core.paginator import Paginator from django.db.models import QuerySet from django.template.loader import render_to_string from django.utils import timezone @@ -45,30 +46,31 @@ def add_arguments(self, parser): help="Create a full snapshot rather than incremental.", ) parser.add_argument("-o", "--output", help="Output dir for xml files", required=True) + parser.add_argument("-c", "--chunk", help="Number of analyses per chunk", default=100, nargs='?', type=int) def get_analysis_context(self, analysis: AnalysisJob): try: analysis_taxonomy: Optional[AnalysisJobTaxonomy] = AnalysisJobTaxonomy.objects.get( - analysis_id=str(analysis.job_id) + analysis_id=analysis.job_id ) except AnalysisJobTaxonomy.DoesNotExist: - logger.warning(f"Could not find analysis job taxonomy for {analysis.job_id}") + logger.debug(f"Could not find analysis job taxonomy for {analysis.job_id}") analysis_taxonomy = None try: go_annotation: Optional[AnalysisJobGoTerm] = AnalysisJobGoTerm.objects.get( - pk=str(analysis.job_id) + pk=analysis.job_id ) except AnalysisJobGoTerm.DoesNotExist: - logger.warning(f"Could not find go terms for {analysis.job_id}") + logger.debug(f"Could not find go terms for {analysis.job_id}") go_annotation = None try: ips_annotation: Optional[AnalysisJobInterproIdentifier] = AnalysisJobInterproIdentifier.objects.get( - pk=str(analysis.job_id) + pk=analysis.job_id ) except AnalysisJobInterproIdentifier.DoesNotExist: - logger.warning(f"Could not find IPS terms for {analysis.job_id}") + logger.debug(f"Could not find IPS terms for {analysis.job_id}") ips_annotation = None biome_list = analysis.study.biome.lineage.split(":")[1:] @@ -161,6 +163,7 @@ def handle(self, *args, **options): """Dump EBI Search XML file of analyses""" is_full_snapshot: str = options["full"] output_dir: str = options["output"] + chunk_size: int = options["chunk"] pathlib.Path(output_dir).mkdir(parents=True, exist_ok=True) @@ -183,17 +186,21 @@ def handle(self, *args, **options): ) ) - additions_file = pathlib.Path(output_dir) / pathlib.Path('analyses.xml') - with open(additions_file, 'w') as a: - self.write_without_blank_lines(a, - render_to_string( - "ebi_search/analyses.xml", - { - "additions": (self.get_analysis_context(analysis) for analysis in analyses), - "count": analyses.count() - } + paginated_analyses = Paginator(analyses, chunk_size) + + for page in paginated_analyses: + logger.info(f"Dumping {page.number = }/{paginated_analyses.num_pages}") + additions_file = pathlib.Path(output_dir) / pathlib.Path(f'analyses_{page.number:04}.xml') + with open(additions_file, 'w') as a: + self.write_without_blank_lines(a, + render_to_string( + "ebi_search/analyses.xml", + { + "additions": (self.get_analysis_context(analysis) for analysis in page), + "count": len(page) + } + ) ) - ) nowish = timezone.now() + timedelta(minutes=1) # Small buffer into the future so that the indexing time remains ahead of auto-now updated times. diff --git a/emgcli/__init__.py b/emgcli/__init__.py index 3d7256add..8d1a700d2 100644 --- a/emgcli/__init__.py +++ b/emgcli/__init__.py @@ -1 +1 @@ -__version__: str = "2.4.37" +__version__: str = "2.4.38" diff --git a/pyproject.toml b/pyproject.toml index a78ee347e..cef87bf5b 100644 --- a/pyproject.toml +++ b/pyproject.toml @@ -117,7 +117,7 @@ max-line-length = 119 """ [tool.bumpversion] -current_version = "2.4.37" +current_version = "2.4.38" [[tool.bumpversion.files]] filename = "emgcli/__init__.py" From 28908ca3b77a091d67a912641218d57d3dd11e73 Mon Sep 17 00:00:00 2001 From: sandyr Date: Thu, 16 Nov 2023 11:30:04 +0000 Subject: [PATCH 10/24] escapes html chars in ebi search dump --- .../commands/ebi_search_analysis_dump.py | 2 +- emgapi/templates/ebi_search/analysis.xml | 30 +++++++++---------- emgapi/templates/ebi_search/projects.xml | 10 +++---- emgcli/__init__.py | 2 +- pyproject.toml | 2 +- 5 files changed, 23 insertions(+), 23 deletions(-) diff --git a/emgapi/management/commands/ebi_search_analysis_dump.py b/emgapi/management/commands/ebi_search_analysis_dump.py index f2713f3fb..8514f98b1 100644 --- a/emgapi/management/commands/ebi_search_analysis_dump.py +++ b/emgapi/management/commands/ebi_search_analysis_dump.py @@ -129,7 +129,7 @@ def get_analysis_context(self, analysis: AnalysisJob): try: indexable_value = float(indexable_value.strip()) except ValueError: - logger.warning( + logger.debug( f"Could not float-parse supposedly numeric field {indexable_name} : {indexable_value}") continue sample_metadata[ diff --git a/emgapi/templates/ebi_search/analysis.xml b/emgapi/templates/ebi_search/analysis.xml index 841c2c079..578d24c12 100644 --- a/emgapi/templates/ebi_search/analysis.xml +++ b/emgapi/templates/ebi_search/analysis.xml @@ -9,57 +9,57 @@ assembly {{ analysis.pipeline.release_version }} - {{ analysis.sample.sample_name | safe }} - {{ analysis.study.study_name | safe }} - {{ analysis.study.biome.biome_name | safe }} + {{ analysis.sample.sample_name | escape }} + {{ analysis.study.study_name | escape }} + {{ analysis.study.biome.biome_name | escape }} {% if analysis.sample.species %} - {{ analysis.sample.species | safe }} + {{ analysis.sample.species | escape }} {% endif %} {% if analysis.sample.environment_feature %} - {{ analysis.sample.environment_feature | safe }} + {{ analysis.sample.environment_feature | escape }} {% endif %} {% if analysis.sample.environment_material %} - {{ analysis.sample.environment_material | safe }} + {{ analysis.sample.environment_material | escape }} {% endif %} - {{ analysis.sample.sample_alias | safe }} - {{ analysis.study.study_name | safe }} + {{ analysis.sample.sample_alias | escape }} + {{ analysis.study.study_name | escape }} {% for biome_element in analysis_biome %} {% if forloop.first %} - {{ biome_element | safe }} + {{ biome_element | escape }} {% else %} - {{ biome_element | safe }} + {{ biome_element | escape }} {% endif %} {% endfor %} {% for metadata_key, metadata_value in sample_metadata.items %} - {{ metadata_value | safe }} + {{ metadata_value | escape }} {% endfor %} {% for taxonomy_lineage_elements in analysis_taxonomies %} {% for taxonomy_element in taxonomy_lineage_elements %} {% if forloop.first %} - {{ taxonomy_element | safe }} + {{ taxonomy_element | escape }} {% else %} - {{ taxonomy_element | safe }} + {{ taxonomy_element | escape }} {% endif %} {% endfor %} {% endfor %} {% for go_slim in analysis_go_entries %} - {{ go_slim.description | safe }} + {{ go_slim.description | escape }} {% endfor %} {% for ips in analysis_ips_entries %} - {{ ips.description | safe }} + {{ ips.description | escape }} {% endfor %} diff --git a/emgapi/templates/ebi_search/projects.xml b/emgapi/templates/ebi_search/projects.xml index d8827e4a1..d8c9d2d04 100644 --- a/emgapi/templates/ebi_search/projects.xml +++ b/emgapi/templates/ebi_search/projects.xml @@ -7,8 +7,8 @@ {% for addition in additions %} {% with addition.study as study %} - {{ study.study_name | safe }} - {{ study.study_abstract | safe }} + {{ study.study_name | escape }} + {{ study.study_abstract | escape }} @@ -19,13 +19,13 @@ {% for biome_element in addition.biome_list %} {% if forloop.first %} - {{ biome_element | safe }} + {{ biome_element | escape }} {% else %} - {{ biome_element | safe }} + {{ biome_element | escape }} {% endif %} {% endfor %} - {{ study.centre_name | safe }} + {{ study.centre_name | escape }} diff --git a/emgcli/__init__.py b/emgcli/__init__.py index 8d1a700d2..48a6caa0d 100644 --- a/emgcli/__init__.py +++ b/emgcli/__init__.py @@ -1 +1 @@ -__version__: str = "2.4.38" +__version__: str = "2.4.39" diff --git a/pyproject.toml b/pyproject.toml index cef87bf5b..780720c82 100644 --- a/pyproject.toml +++ b/pyproject.toml @@ -117,7 +117,7 @@ max-line-length = 119 """ [tool.bumpversion] -current_version = "2.4.38" +current_version = "2.4.39" [[tool.bumpversion.files]] filename = "emgcli/__init__.py" From 585220161374b8b1dc3e611b3987166e35c2c38a Mon Sep 17 00:00:00 2001 From: sandyr Date: Wed, 3 Jan 2024 15:17:40 +0000 Subject: [PATCH 11/24] restore ability to recreate test DB fixtures; recreate them --- config/local-lite.yml | 1 + emgena/models.py | 9 ++++++--- 2 files changed, 7 insertions(+), 3 deletions(-) diff --git a/config/local-lite.yml b/config/local-lite.yml index dd2fa4381..0162f7cbd 100644 --- a/config/local-lite.yml +++ b/config/local-lite.yml @@ -9,6 +9,7 @@ emg: era: ENGINE: 'django.db.backends.sqlite3' NAME: '/opt/ci/testdbs/ena-testdb.sqlite' + ERA_TABLESPACE_PREFIX: '' admin: True downloads_bypass_nginx: True diff --git a/emgena/models.py b/emgena/models.py index c3aaba848..ad7e9b0aa 100644 --- a/emgena/models.py +++ b/emgena/models.py @@ -27,7 +27,9 @@ from __future__ import unicode_literals from datetime import date -from django.db import models, NotSupportedError + +from django.conf import settings +from django.db import models class Status(models.IntegerChoices): @@ -197,8 +199,9 @@ class Meta(StudyAbstract.Meta): # ERA needs to be appended as the default connection tries to use # the PUBLIC SYNONYM (according to ENA) and it's not working ATM # we were advised to prefix the views and this is the simplest way. - # The short-term plan is to remove the dependency of ENA databases - db_table = 'ERA\".\"V_MGP_RUN_STUDY' + # The short-term plan is to remove the dependency of ENA databases + _prefix_workaround = settings.DATABASES['era'].get('ERA_TABLESPACE_PREFIX', 'ERA\".\"') + db_table = f'{_prefix_workaround}V_MGP_RUN_STUDY' class AssemblyStudy(StudyAbstract): From 6b4009803c57790ffa9ed35da792d328030712dc Mon Sep 17 00:00:00 2001 From: sandyr Date: Wed, 3 Jan 2024 15:31:41 +0000 Subject: [PATCH 12/24] ensure biome hierarchical_field is not empty for root-tagged studies --- emgapi/management/commands/ebi_search_analysis_dump.py | 3 ++- emgapi/management/commands/ebi_search_study_dump.py | 2 +- 2 files changed, 3 insertions(+), 2 deletions(-) diff --git a/emgapi/management/commands/ebi_search_analysis_dump.py b/emgapi/management/commands/ebi_search_analysis_dump.py index 8514f98b1..cb49508f8 100644 --- a/emgapi/management/commands/ebi_search_analysis_dump.py +++ b/emgapi/management/commands/ebi_search_analysis_dump.py @@ -73,7 +73,8 @@ def get_analysis_context(self, analysis: AnalysisJob): logger.debug(f"Could not find IPS terms for {analysis.job_id}") ips_annotation = None - biome_list = analysis.study.biome.lineage.split(":")[1:] + biome_list = analysis.study.biome.lineage.split(":")[1:] or ['root'] + # to ensure there are no empty hierarchical fields taxonomy_lists = [] if analysis_taxonomy: diff --git a/emgapi/management/commands/ebi_search_study_dump.py b/emgapi/management/commands/ebi_search_study_dump.py index 1bee1aa08..888529262 100644 --- a/emgapi/management/commands/ebi_search_study_dump.py +++ b/emgapi/management/commands/ebi_search_study_dump.py @@ -54,7 +54,7 @@ def write_without_blank_lines(fp, string): @staticmethod def get_study_context(study: Study): - biome_list = study.biome.lineage.split(":")[1:] + biome_list = study.biome.lineage.split(":")[1:] or ['root'] return { "study": study, From d185d4e1b46083c772d4869fa4a3c782fcec2be4 Mon Sep 17 00:00:00 2001 From: sandyr Date: Wed, 3 Jan 2024 15:59:02 +0000 Subject: [PATCH 13/24] allow ERA database to be non existent --- emgena/models.py | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/emgena/models.py b/emgena/models.py index ad7e9b0aa..85beb7a48 100644 --- a/emgena/models.py +++ b/emgena/models.py @@ -200,7 +200,7 @@ class Meta(StudyAbstract.Meta): # the PUBLIC SYNONYM (according to ENA) and it's not working ATM # we were advised to prefix the views and this is the simplest way. # The short-term plan is to remove the dependency of ENA databases - _prefix_workaround = settings.DATABASES['era'].get('ERA_TABLESPACE_PREFIX', 'ERA\".\"') + _prefix_workaround = settings.DATABASES.get('era', {}).get('ERA_TABLESPACE_PREFIX', 'ERA\".\"') db_table = f'{_prefix_workaround}V_MGP_RUN_STUDY' From f36021e9f7de2c562a2c1e6b34bf0b7d27795f0f Mon Sep 17 00:00:00 2001 From: sandyr Date: Fri, 5 Jan 2024 12:56:41 +0000 Subject: [PATCH 14/24] bugfixes on analysis-run dumper --- .../commands/ebi_search_analysis_dump.py | 14 +++++++------- emgapi/templates/ebi_search/analysis.xml | 19 +++++++++++++++---- emgcli/__init__.py | 2 +- pyproject.toml | 2 +- 4 files changed, 24 insertions(+), 13 deletions(-) diff --git a/emgapi/management/commands/ebi_search_analysis_dump.py b/emgapi/management/commands/ebi_search_analysis_dump.py index cb49508f8..8bee0cfbf 100644 --- a/emgapi/management/commands/ebi_search_analysis_dump.py +++ b/emgapi/management/commands/ebi_search_analysis_dump.py @@ -59,7 +59,7 @@ def get_analysis_context(self, analysis: AnalysisJob): try: go_annotation: Optional[AnalysisJobGoTerm] = AnalysisJobGoTerm.objects.get( - pk=analysis.job_id + pk=str(analysis.job_id) ) except AnalysisJobGoTerm.DoesNotExist: logger.debug(f"Could not find go terms for {analysis.job_id}") @@ -67,7 +67,7 @@ def get_analysis_context(self, analysis: AnalysisJob): try: ips_annotation: Optional[AnalysisJobInterproIdentifier] = AnalysisJobInterproIdentifier.objects.get( - pk=analysis.job_id + pk=str(analysis.job_id) ) except AnalysisJobInterproIdentifier.DoesNotExist: logger.debug(f"Could not find IPS terms for {analysis.job_id}") @@ -203,10 +203,10 @@ def handle(self, *args, **options): ) ) - nowish = timezone.now() + timedelta(minutes=1) - # Small buffer into the future so that the indexing time remains ahead of auto-now updated times. + nowish = timezone.now() + timedelta(minutes=1) + # Small buffer into the future so that the indexing time remains ahead of auto-now updated times. - for analysis in analyses: - analysis.last_indexed = nowish + for analysis in page: + analysis.last_indexed = nowish - AnalysisJob.objects.bulk_update(analyses, fields=["last_indexed"]) + AnalysisJob.objects.bulk_update(page, fields=["last_indexed"]) diff --git a/emgapi/templates/ebi_search/analysis.xml b/emgapi/templates/ebi_search/analysis.xml index 578d24c12..f4ffcca1b 100644 --- a/emgapi/templates/ebi_search/analysis.xml +++ b/emgapi/templates/ebi_search/analysis.xml @@ -7,9 +7,10 @@ - assembly + {{ analysis.experiment_type.experiment_type }} {{ analysis.pipeline.release_version }} {{ analysis.sample.sample_name | escape }} + {{ analysis.sample.sample_desc | escape }} {{ analysis.study.study_name | escape }} {{ analysis.study.biome.biome_name | escape }} @@ -66,16 +67,26 @@ + {# biosample #} + {% if analysis.sample.primary_accession %} + + {% endif %} + + {# INSDC sample like DRSxx, ERSxx, SRSxx #} + {% if analysis.sample.accession and analysis.sample.accession|slice:"1:3" == "RS"%} + + {% endif %} + {# Assembly analysis #} - {% if analysis.assembly and analysis.assembly.accession|slice:":4" == "GCA_" %} - - + {% if analysis.assembly %} + {% endif %} {# WGS/Amplicon analysis #} {% if analysis.run %} {% endif %} + {% for go in analysis_go_entries %} {% endfor %} diff --git a/emgcli/__init__.py b/emgcli/__init__.py index ff3a98ea4..c6dbbedcb 100644 --- a/emgcli/__init__.py +++ b/emgcli/__init__.py @@ -1 +1 @@ -__version__: str = "2.4.40" +__version__: str = "2.4.41" diff --git a/pyproject.toml b/pyproject.toml index b6e97a4b9..54396e44e 100644 --- a/pyproject.toml +++ b/pyproject.toml @@ -117,7 +117,7 @@ max-line-length = 119 """ [tool.bumpversion] -current_version = "2.4.40" +current_version = "2.4.41" [[tool.bumpversion.files]] filename = "emgcli/__init__.py" From 67edbcd3821de2c8bdd4949e8b8578374a0e411d Mon Sep 17 00:00:00 2001 From: sandyr Date: Wed, 17 Jan 2024 18:13:16 +0000 Subject: [PATCH 15/24] optimising speed of dump (particularly mongo) --- .github/workflows/test.yml | 4 +++ .gitignore | 14 ++++++++++- .../commands/ebi_search_analysis_dump.py | 18 +++++++------ ..._last_updates_on_ebi_searchable_models.py} | 2 +- emgapi/migrations/0016_auto_20240117_1757.py | 22 ++++++++++++++++ emgapi/models.py | 8 ++++++ emgapi/templates/ebi_search/analysis.xml | 12 ++------- emgapianns/models.py | 22 ++++++++-------- emgapianns/utils.py | 25 +++++++++++++++++++ emgcli/__init__.py | 2 +- emgcli/settings.py | 15 ++++++++--- pyproject.toml | 2 +- 12 files changed, 112 insertions(+), 34 deletions(-) rename emgapi/migrations/{0013_auto_20231110_1329.py => 0015_last_updates_on_ebi_searchable_models.py} (94%) create mode 100644 emgapi/migrations/0016_auto_20240117_1757.py create mode 100644 emgapianns/utils.py diff --git a/.github/workflows/test.yml b/.github/workflows/test.yml index 99fcb913d..49e075edb 100644 --- a/.github/workflows/test.yml +++ b/.github/workflows/test.yml @@ -38,6 +38,10 @@ jobs: pip install install .[tests] pip freeze + - name: Check for unmigrated code changes + run: | + python emgcli/manage.py makemigrations --noinput --check --dry-run + - name: 🧪 - Testing run: | cat $EMG_CONFIG diff --git a/.gitignore b/.gitignore index 583ebfecf..14cd294c5 100644 --- a/.gitignore +++ b/.gitignore @@ -29,4 +29,16 @@ logs secret.key -dumps \ No newline at end of file +dumps + +/config/*.yml +/config/*.yaml +!/config/*local* + +/config/*.yml +/config/*.yaml +!/config/*local* + +/config/*.yml +/config/*.yaml +!/config/*local* \ No newline at end of file diff --git a/emgapi/management/commands/ebi_search_analysis_dump.py b/emgapi/management/commands/ebi_search_analysis_dump.py index 8bee0cfbf..39d9fd12d 100644 --- a/emgapi/management/commands/ebi_search_analysis_dump.py +++ b/emgapi/management/commands/ebi_search_analysis_dump.py @@ -47,11 +47,12 @@ def add_arguments(self, parser): ) parser.add_argument("-o", "--output", help="Output dir for xml files", required=True) parser.add_argument("-c", "--chunk", help="Number of analyses per chunk", default=100, nargs='?', type=int) + parser.add_argument("-m", "--max_pages", help="Max number of pages to dump", default=-1, type=int) def get_analysis_context(self, analysis: AnalysisJob): try: analysis_taxonomy: Optional[AnalysisJobTaxonomy] = AnalysisJobTaxonomy.objects.get( - analysis_id=analysis.job_id + pk=str(analysis.job_id) ) except AnalysisJobTaxonomy.DoesNotExist: logger.debug(f"Could not find analysis job taxonomy for {analysis.job_id}") @@ -88,7 +89,7 @@ def get_analysis_context(self, analysis: AnalysisJob): for taxonomy_attribute in taxonomy_attributes: if taxonomy_attribute: for tax in taxonomy_attribute: - tax_lineage_list = list(filter(None, tax.lineage.split(":"))) + tax_lineage_list = list(filter(None, tax.organism.pk.split('|')[0].split(":"))) if len(tax_lineage_list) > 1: taxonomy_lists.append( tax_lineage_list @@ -139,13 +140,13 @@ def get_analysis_context(self, analysis: AnalysisJob): if 'location_name' not in sample_metadata and analysis.sample.geo_loc_name: sample_metadata['location_name'] = analysis.sample.geo_loc_name - return { "analysis": analysis, "analysis_biome": biome_list, "analysis_taxonomies": taxonomy_lists, - "analysis_go_entries": go_annotation.go_terms if go_annotation else [], - "analysis_ips_entries": ips_annotation.interpro_identifiers if ips_annotation else [], + "analysis_go_entries": [go.go_term.pk for go in go_annotation.go_terms] if go_annotation else [], + "analysis_ips_entries": [ipr.interpro_identifier.pk for ipr in ips_annotation.interpro_identifiers] if ips_annotation else [], + # .pk ensures the IPR and GO documents are not queried on mongo, which would have a big performance hit "sample_metadata": sample_metadata, } @@ -168,7 +169,7 @@ def handle(self, *args, **options): pathlib.Path(output_dir).mkdir(parents=True, exist_ok=True) - analyses: QuerySet = AnalysisJob.objects.available(None) + analyses: QuerySet = AnalysisJob.objects_dump.available(None) if not is_full_snapshot: analyses = AnalysisJob.objects_for_indexing.to_add() @@ -190,6 +191,10 @@ def handle(self, *args, **options): paginated_analyses = Paginator(analyses, chunk_size) for page in paginated_analyses: + if (mp := options["max_pages"]) >= 0: + if page.number > mp: + logger.warning("Skipping remaining pages") + break logger.info(f"Dumping {page.number = }/{paginated_analyses.num_pages}") additions_file = pathlib.Path(output_dir) / pathlib.Path(f'analyses_{page.number:04}.xml') with open(additions_file, 'w') as a: @@ -202,7 +207,6 @@ def handle(self, *args, **options): } ) ) - nowish = timezone.now() + timedelta(minutes=1) # Small buffer into the future so that the indexing time remains ahead of auto-now updated times. diff --git a/emgapi/migrations/0013_auto_20231110_1329.py b/emgapi/migrations/0015_last_updates_on_ebi_searchable_models.py similarity index 94% rename from emgapi/migrations/0013_auto_20231110_1329.py rename to emgapi/migrations/0015_last_updates_on_ebi_searchable_models.py index 998fc7202..ce0b239ac 100644 --- a/emgapi/migrations/0013_auto_20231110_1329.py +++ b/emgapi/migrations/0015_last_updates_on_ebi_searchable_models.py @@ -6,7 +6,7 @@ class Migration(migrations.Migration): dependencies = [ - ('emgapi', '0012_alter_publication_pub_type'), + ('emgapi', '0014_suppression_reason_ancestor_suppressed'), ] operations = [ diff --git a/emgapi/migrations/0016_auto_20240117_1757.py b/emgapi/migrations/0016_auto_20240117_1757.py new file mode 100644 index 000000000..17f1520b1 --- /dev/null +++ b/emgapi/migrations/0016_auto_20240117_1757.py @@ -0,0 +1,22 @@ +# Generated by Django 3.2.23 on 2024-01-17 17:57 + +from django.db import migrations + + +class Migration(migrations.Migration): + + dependencies = [ + ('emgapi', '0015_last_updates_on_ebi_searchable_models'), + ] + + operations = [ + migrations.AlterModelOptions( + name='blacklistedstudy', + options={'managed': False, 'verbose_name': 'blacklisted study', 'verbose_name_plural': 'blacklisted studies'}, + ), + migrations.RenameField( + model_name='analysisjob', + old_name='analysis_summary_json', + new_name='analysis_summary', + ), + ] diff --git a/emgapi/models.py b/emgapi/models.py index c902288a7..9d0830c04 100644 --- a/emgapi/models.py +++ b/emgapi/models.py @@ -1688,6 +1688,13 @@ def available(self, request): return self.get_queryset().available(request) +class AnalysisJobDumpManager(AnalysisJobManager): + def get_queryset(self): + return AnalysisJobQuerySet(self.model, using=self._db) \ + .select_related( + 'analysis_status','experiment_type', 'assembly', 'pipeline', 'run', 'sample', 'study') + + class AnalysisJob(SuppressibleModel, PrivacyControlledModel, EbiSearchIndexedModel): def __init__(self, *args, **kwargs): super(AnalysisJob, self).__init__(*args, **kwargs) @@ -1761,6 +1768,7 @@ def downloads(self): objects = AnalysisJobManager() objects_admin = models.Manager() + objects_dump = AnalysisJobDumpManager() class Meta: db_table = 'ANALYSIS_JOB' diff --git a/emgapi/templates/ebi_search/analysis.xml b/emgapi/templates/ebi_search/analysis.xml index f4ffcca1b..3ca50375e 100644 --- a/emgapi/templates/ebi_search/analysis.xml +++ b/emgapi/templates/ebi_search/analysis.xml @@ -54,14 +54,6 @@ {% endfor %} {% endfor %} - - {% for go_slim in analysis_go_entries %} - {{ go_slim.description | escape }} - {% endfor %} - - {% for ips in analysis_ips_entries %} - {{ ips.description | escape }} - {% endfor %} @@ -88,10 +80,10 @@ {% endif %} {% for go in analysis_go_entries %} - + {% endfor %} {% for ips in analysis_ips_entries %} - + {% endfor %} \ No newline at end of file diff --git a/emgapianns/models.py b/emgapianns/models.py index b07ea59b7..af5d60f9f 100644 --- a/emgapianns/models.py +++ b/emgapianns/models.py @@ -106,7 +106,7 @@ class BaseAnalysisJobAnnotation(mongoengine.EmbeddedDocument): class AnalysisJobGoTermAnnotation(BaseAnalysisJobAnnotation): - go_term = mongoengine.ReferenceField(GoTerm, required=True) + go_term = mongoengine.LazyReferenceField(GoTerm, required=True) @property def accession(self): @@ -123,8 +123,10 @@ def lineage(self): class AnalysisJobInterproIdentifierAnnotation(BaseAnalysisJobAnnotation): - interpro_identifier = mongoengine.ReferenceField(InterproIdentifier, - required=True) + interpro_identifier = mongoengine.LazyReferenceField( + InterproIdentifier, + required=True + ) @property def accession(self): @@ -142,7 +144,7 @@ def lineage(self): class AnalysisJobKeggModuleAnnotation(mongoengine.EmbeddedDocument): """KEGG modules on a given Analysis Job. """ - module = mongoengine.ReferenceField(KeggModule, required=True) + module = mongoengine.LazyReferenceField(KeggModule, required=True) completeness = mongoengine.FloatField(default=0.0) matching_kos = mongoengine.ListField(mongoengine.StringField(), default=list) missing_kos = mongoengine.ListField(mongoengine.StringField(), default=list) @@ -163,7 +165,7 @@ def name(self): class AnalysisJobPfamAnnotation(BaseAnalysisJobAnnotation): """Pfam on a given Analysis Job. """ - pfam_entry = mongoengine.ReferenceField(PfamEntry, required=True) + pfam_entry = mongoengine.LazyReferenceField(PfamEntry, required=True) @property def accession(self): @@ -177,7 +179,7 @@ def description(self): class AnalysisJobCOGAnnotation(BaseAnalysisJobAnnotation): """COG on a given Analysis Job. """ - cog = mongoengine.ReferenceField(COG, required=True) + cog = mongoengine.LazyReferenceField(COG, required=True) @property def accession(self): @@ -199,7 +201,7 @@ class AnalysisJobGenomePropAnnotation(mongoengine.EmbeddedDocument): (PARTIAL_PRESENCE, 'Partial'), (NO_PRESENCE, 'No'), ) - genome_property = mongoengine.ReferenceField(GenomeProperty, required=True) + genome_property = mongoengine.LazyReferenceField(GenomeProperty, required=True) presence = mongoengine.IntField(required=True, choices=PRESENCE_CHOICES) @property @@ -214,7 +216,7 @@ def description(self): class AnalysisJobKeggOrthologAnnotation(BaseAnalysisJobAnnotation): """KEGG KO on a given Analysis Job. """ - ko = mongoengine.ReferenceField(KeggOrtholog, required=True) + ko = mongoengine.LazyReferenceField(KeggOrtholog, required=True) @property def accession(self): @@ -228,7 +230,7 @@ def description(self): class AnalysisJobAntiSmashGCAnnotation(BaseAnalysisJobAnnotation): """antiSMASH gene cluster on a given Analysis Job """ - gene_cluster = mongoengine.ReferenceField(AntiSmashGeneCluster, required=True) + gene_cluster = mongoengine.LazyReferenceField(AntiSmashGeneCluster, required=True) @property def accession(self): @@ -333,7 +335,7 @@ class Organism(mongoengine.Document): class AnalysisJobOrganism(mongoengine.EmbeddedDocument): count = mongoengine.IntField(required=True) - organism = mongoengine.ReferenceField(Organism) + organism = mongoengine.LazyReferenceField(Organism) @property def lineage(self): diff --git a/emgapianns/utils.py b/emgapianns/utils.py new file mode 100644 index 000000000..25e715876 --- /dev/null +++ b/emgapianns/utils.py @@ -0,0 +1,25 @@ +import logging +from pymongo import monitoring + + +class MongoCommandLogger(monitoring.CommandListener): + + def started(self, event): + logging.debug( + f"Command {event.command}" + ) + logging.info( + f"Command {event.command_name} with request id {event.request_id} started on server {event.connection_id}" + ) + + def succeeded(self, event): + logging.info( + f"Command {event.command_name} with request id {event.request_id} on server {event.connection_id} " + f"succeeded in {event.duration_micros} microseconds" + ) + + def failed(self, event): + logging.info( + f"Command {event.command_name} with request id {event.request_id} on server {event.connection_id} " + f"failed in {event.duration_micros} microseconds" + ) diff --git a/emgcli/__init__.py b/emgcli/__init__.py index c6dbbedcb..bd355a7c0 100644 --- a/emgcli/__init__.py +++ b/emgcli/__init__.py @@ -1 +1 @@ -__version__: str = "2.4.41" +__version__: str = "2.4.43" diff --git a/emgcli/settings.py b/emgcli/settings.py index d16bfa029..4fb645d91 100644 --- a/emgcli/settings.py +++ b/emgcli/settings.py @@ -37,6 +37,9 @@ from os.path import expanduser from corsheaders.defaults import default_headers +from pymongo import monitoring + +from emgapianns.utils import MongoCommandLogger try: from YamJam import yamjam, YAMLError @@ -45,7 +48,6 @@ logger = logging.getLogger(__name__) - # Build paths inside the project like this: os.path.join(BASE_DIR, ...) BASE_DIR = os.path.dirname(os.path.dirname(os.path.abspath(__file__))) EMG_CONFIG = os.environ.get( @@ -161,8 +163,15 @@ } } -# Quick-start development settings - unsuitable for production -# See https://docs.djangoproject.com/en/1.11/howto/deployment/checklist/ +if EMG_CONF.get('emg', {}).get('log_db_queries', False): + monitoring.register(MongoCommandLogger()) + LOGGING['loggers']['django.db.backends'] = { + 'handlers': ['default', 'console'], + 'level': 'DEBUG', + 'propagate': False, + } + LOGGING['loggers']['']['level'] = 'DEBUG' + def create_secret_key(var_dir): secret_key = None diff --git a/pyproject.toml b/pyproject.toml index 1ff2d1bb6..5e0a68b74 100644 --- a/pyproject.toml +++ b/pyproject.toml @@ -117,7 +117,7 @@ max-line-length = 119 """ [tool.bumpversion] -current_version = "2.4.41" +current_version = "2.4.43" [[tool.bumpversion.files]] filename = "emgcli/__init__.py" From 0e214581bdc7bfa0c6939350253be37f7a43b844 Mon Sep 17 00:00:00 2001 From: sandyr Date: Wed, 17 Jan 2024 18:32:09 +0000 Subject: [PATCH 16/24] avoids serializing last_indexed timestamps --- emgapi/serializers.py | 4 +++- 1 file changed, 3 insertions(+), 1 deletion(-) diff --git a/emgapi/serializers.py b/emgapi/serializers.py index f55f71401..0079a0c66 100644 --- a/emgapi/serializers.py +++ b/emgapi/serializers.py @@ -1020,7 +1020,8 @@ class Meta: 'secondary_accession', 'is_suppressed', 'suppressed_at', - 'suppression_reason' + 'suppression_reason', + 'last_indexed' ) @@ -1409,6 +1410,7 @@ class Meta: 'is_suppressed', 'suppression_reason', 'suppressed_at', + 'last_indexed', ) From 0a8f87257cc27c5d5a2903436b361b1fd30a14cd Mon Sep 17 00:00:00 2001 From: sandyr Date: Wed, 17 Jan 2024 18:41:44 +0000 Subject: [PATCH 17/24] loosens test since last-updates are auto fields --- tests/api/test_study.py | 3 ++- 1 file changed, 2 insertions(+), 1 deletion(-) diff --git a/tests/api/test_study.py b/tests/api/test_study.py index b665c70b4..3cbf0c4ab 100644 --- a/tests/api/test_study.py +++ b/tests/api/test_study.py @@ -1,5 +1,6 @@ #!/usr/bin/env python # -*- coding: utf-8 -*- +import datetime # Copyright 2020 EMBL - European Bioinformatics Institute # @@ -45,7 +46,7 @@ def test_details(self, client, study): assert _attr['study-abstract'] == "abcdefghijklmnoprstuvwyz" assert _attr['study-name'] == "Example study name SRP01234" assert _attr['data-origination'] == "HARVESTED" - assert _attr['last-update'] == "1970-01-01T00:00:00" + assert _attr['last-update'][:4] == datetime.datetime.now().isoformat()[:4] assert _attr['bioproject'] == "PRJDB1234" assert _attr['is-private'] == False From e10fd33156f62ae16089b7e4c1128aa5cc02fbd4 Mon Sep 17 00:00:00 2001 From: sandyr Date: Mon, 22 Jan 2024 11:58:09 +0000 Subject: [PATCH 18/24] materialise (fetch) lazyily referenced mongo embeds when accessing related attributes --- emgapianns/models.py | 54 ++++++++++++++++++++++++++++++++------------ 1 file changed, 40 insertions(+), 14 deletions(-) diff --git a/emgapianns/models.py b/emgapianns/models.py index af5d60f9f..8d5ca33ff 100644 --- a/emgapianns/models.py +++ b/emgapianns/models.py @@ -1,5 +1,6 @@ #!/usr/bin/env python # -*- coding: utf-8 -*- +from functools import cached_property # Copyright 2019 EMBL - European Bioinformatics Institute # @@ -108,17 +109,22 @@ class AnalysisJobGoTermAnnotation(BaseAnalysisJobAnnotation): go_term = mongoengine.LazyReferenceField(GoTerm, required=True) + + @cached_property + def materialised_go_term(self): + return self.go_term.fetch() + @property def accession(self): - return self.go_term.accession + return self.materialised_go_term.accession @property def description(self): - return self.go_term.description + return self.materialised_go_term.description @property def lineage(self): - return self.go_term.lineage + return self.materialised_go_term.lineage class AnalysisJobInterproIdentifierAnnotation(BaseAnalysisJobAnnotation): @@ -128,17 +134,21 @@ class AnalysisJobInterproIdentifierAnnotation(BaseAnalysisJobAnnotation): required=True ) + @cached_property + def materialised_interpro_identifier(self): + return self.interpro_identifier.fetch() + @property def accession(self): - return self.interpro_identifier.accession + return self.materialised_interpro_identifier.accession @property def description(self): - return self.interpro_identifier.description + return self.materialised_interpro_identifier.description @property def lineage(self): - return self.interpro_identifier.lineage + return self.materialised_interpro_identifier.lineage class AnalysisJobKeggModuleAnnotation(mongoengine.EmbeddedDocument): @@ -167,13 +177,17 @@ class AnalysisJobPfamAnnotation(BaseAnalysisJobAnnotation): """ pfam_entry = mongoengine.LazyReferenceField(PfamEntry, required=True) + @cached_property + def materialised_pfam_entry(self): + return self.pfam_entry.fetch() + @property def accession(self): - return self.pfam_entry.accession + return self.materialised_pfam_entry.accession @property def description(self): - return self.pfam_entry.description + return self.materialised_pfam_entry.description class AnalysisJobCOGAnnotation(BaseAnalysisJobAnnotation): @@ -181,13 +195,17 @@ class AnalysisJobCOGAnnotation(BaseAnalysisJobAnnotation): """ cog = mongoengine.LazyReferenceField(COG, required=True) + @cached_property + def materialised_cog(self): + return self.cog.fetch() + @property def accession(self): - return self.cog.accession + return self.materialised_cog.accession @property def description(self): - return self.cog.description + return self.materialised_cog.description class AnalysisJobGenomePropAnnotation(mongoengine.EmbeddedDocument): @@ -218,13 +236,17 @@ class AnalysisJobKeggOrthologAnnotation(BaseAnalysisJobAnnotation): """ ko = mongoengine.LazyReferenceField(KeggOrtholog, required=True) + @cached_property + def materialised_ko(self): + return self.ko.fetch() + @property def accession(self): - return self.ko.accession + return self.materialised_ko.accession @property def description(self): - return self.ko.description + return self.materialised_ko.description class AnalysisJobAntiSmashGCAnnotation(BaseAnalysisJobAnnotation): @@ -232,13 +254,17 @@ class AnalysisJobAntiSmashGCAnnotation(BaseAnalysisJobAnnotation): """ gene_cluster = mongoengine.LazyReferenceField(AntiSmashGeneCluster, required=True) + @cached_property + def materialised_gene_cluster(self): + return self.gene_cluster.fetch() + @property def accession(self): - return self.gene_cluster.accession + return self.materialised_gene_cluster.accession @property def description(self): - return self.gene_cluster.description + return self.materialised_gene_cluster.description class BaseAnalysisJob(mongoengine.Document): From 0c8c61c4c466ce009c923145d356a5b5a7dae023 Mon Sep 17 00:00:00 2001 From: sandyr Date: Mon, 22 Jan 2024 12:42:02 +0000 Subject: [PATCH 19/24] test updates since last_update field became auto --- tests/api/test_study.py | 47 +++++++++++++++++++++++------------------ 1 file changed, 26 insertions(+), 21 deletions(-) diff --git a/tests/api/test_study.py b/tests/api/test_study.py index 3cbf0c4ab..0f3886d16 100644 --- a/tests/api/test_study.py +++ b/tests/api/test_study.py @@ -70,13 +70,13 @@ def test_public(self, client, study, study_private): assert d['attributes']['accession'] == "MGYS00001234" def test_csv(self, client, studies): - url = reverse("emgapi_v1:studies-list", kwargs={'format': 'csv'}) + url = reverse("emgapi_v1:studies-list", kwargs={'format': 'csv', 'ordering': 'last_update'}) response = client.get(url) assert response.status_code == status.HTTP_200_OK assert response.get('Content-Disposition') == 'attachment; filename="Study.csv"' content = b''.join(response.streaming_content).decode('utf-8') - expected_header = ",".join([ + expected_header = [ "\"accession\"", "\"analyses\"", "\"bioproject\"", @@ -93,29 +93,34 @@ def test_csv(self, client, studies): "\"study_abstract\"", "\"study_name\"", "\"url\"" - ]) - first_row = ",".join([ - "\"MGYS00000001\"", - "\"\"", - "\"PRJDB0001\"", - "\"Centre Name\"", - "\"HARVESTED\"", - "\"\"", + ] + first_row = [ + "MGYS00000001", + "", + "PRJDB0001", + "Centre Name", + "HARVESTED", + "", "False", - "\"1970-01-01T00:00:00\"", - "\"\"", - "\"\"", - "\"\"", - "\"\"", - "\"SRP0001\"", - "\"\"", - "\"Example study name 1\"", - "\"http://testserver/v1/studies/MGYS00000001.csv\"" - ]) + None, + "", + "", + "", + "", + "SRP0001", + "", + "Example study name 1", + "http://testserver/v1/studies/MGYS00000001.csv" + ] rows = content.splitlines() assert len(rows) == 50 assert expected_header == rows[0] - assert first_row == rows[1] + first_row_response = rows[1].split(',') + assert len(first_row_response) == len(first_row) + for response_element, expected_element in zip(first_row_response, first_row): + if expected_element is not None: + assert response_element == expected_element + From a036402bd4c5b2433649ee52c10d1da5429c73fd Mon Sep 17 00:00:00 2001 From: sandyr Date: Mon, 22 Jan 2024 12:42:16 +0000 Subject: [PATCH 20/24] more materialised lazy reference fields --- emgapianns/models.py | 39 +++++++++++++++++++++++++-------------- 1 file changed, 25 insertions(+), 14 deletions(-) diff --git a/emgapianns/models.py b/emgapianns/models.py index 8d5ca33ff..6639cafb1 100644 --- a/emgapianns/models.py +++ b/emgapianns/models.py @@ -109,7 +109,6 @@ class AnalysisJobGoTermAnnotation(BaseAnalysisJobAnnotation): go_term = mongoengine.LazyReferenceField(GoTerm, required=True) - @cached_property def materialised_go_term(self): return self.go_term.fetch() @@ -159,17 +158,21 @@ class AnalysisJobKeggModuleAnnotation(mongoengine.EmbeddedDocument): matching_kos = mongoengine.ListField(mongoengine.StringField(), default=list) missing_kos = mongoengine.ListField(mongoengine.StringField(), default=list) + @cached_property + def materialised_module(self): + return self.module.fetch() + @property def accession(self): - return self.module.accession + return self.materialised_module.accession @property def description(self): - return self.module.description + return self.materialised_module.description @property def name(self): - return self.module.name + return self.materialised_module.name class AnalysisJobPfamAnnotation(BaseAnalysisJobAnnotation): @@ -222,13 +225,17 @@ class AnalysisJobGenomePropAnnotation(mongoengine.EmbeddedDocument): genome_property = mongoengine.LazyReferenceField(GenomeProperty, required=True) presence = mongoengine.IntField(required=True, choices=PRESENCE_CHOICES) + @cached_property + def materialised_genome_property(self): + return self.genome_property.fetch() + @property def accession(self): - return self.genome_property.accession + return self.materialised_genome_property.accession @property def description(self): - return self.genome_property.description + return self.materialised_genome_property.description class AnalysisJobKeggOrthologAnnotation(BaseAnalysisJobAnnotation): @@ -363,37 +370,41 @@ class AnalysisJobOrganism(mongoengine.EmbeddedDocument): count = mongoengine.IntField(required=True) organism = mongoengine.LazyReferenceField(Organism) + @cached_property + def materialised_organism(self): + return self.organism.fetch() + @property def lineage(self): - return self.organism.lineage + return self.materialised_organism.lineage @property def ancestors(self): - return self.organism.ancestors + return self.materialised_organism.ancestors @property def hierarchy(self): - return self.organism.hierarchy + return self.materialised_organism.hierarchy @property def domain(self): - return self.organism.domain + return self.materialised_organism.domain @property def name(self): - return self.organism.name + return self.materialised_organism.name @property def parent(self): - return self.organism.parent + return self.materialised_organism.parent @property def rank(self): - return self.organism.rank + return self.materialised_organism.rank @property def pipeline_version(self): - return self.organism.pipeline_version + return self.materialised_organism.pipeline_version class EMGMeta: pk_field = 'lineage' From 4fd2f3d7188784e4005571af563cc156e92b772c Mon Sep 17 00:00:00 2001 From: sandyr Date: Mon, 22 Jan 2024 12:51:07 +0000 Subject: [PATCH 21/24] insert test studies in reverse to preserve previous ordering --- tests/api/test_study.py | 2 +- tests/test_utils/emg_fixtures.py | 2 +- 2 files changed, 2 insertions(+), 2 deletions(-) diff --git a/tests/api/test_study.py b/tests/api/test_study.py index 0f3886d16..70e00b556 100644 --- a/tests/api/test_study.py +++ b/tests/api/test_study.py @@ -70,7 +70,7 @@ def test_public(self, client, study, study_private): assert d['attributes']['accession'] == "MGYS00001234" def test_csv(self, client, studies): - url = reverse("emgapi_v1:studies-list", kwargs={'format': 'csv', 'ordering': 'last_update'}) + url = reverse("emgapi_v1:studies-list", kwargs={'format': 'csv'}) response = client.get(url) assert response.status_code == status.HTTP_200_OK assert response.get('Content-Disposition') == 'attachment; filename="Study.csv"' diff --git a/tests/test_utils/emg_fixtures.py b/tests/test_utils/emg_fixtures.py index 17e5b706a..f8275c9a8 100644 --- a/tests/test_utils/emg_fixtures.py +++ b/tests/test_utils/emg_fixtures.py @@ -127,7 +127,7 @@ def super_study(study, study_private, biome): @pytest.fixture def studies(biome): studies = [] - for pk in range(1, 50): + for pk in range(49, 0, -1): studies.append( emg_models.Study( biome=biome, From de3b4154fed5075235634237dae9e83323f42663 Mon Sep 17 00:00:00 2001 From: sandyr Date: Mon, 22 Jan 2024 13:50:57 +0000 Subject: [PATCH 22/24] typo --- tests/api/test_study.py | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/tests/api/test_study.py b/tests/api/test_study.py index 70e00b556..b1344f4f4 100644 --- a/tests/api/test_study.py +++ b/tests/api/test_study.py @@ -76,7 +76,7 @@ def test_csv(self, client, studies): assert response.get('Content-Disposition') == 'attachment; filename="Study.csv"' content = b''.join(response.streaming_content).decode('utf-8') - expected_header = [ + expected_header = ",".join([ "\"accession\"", "\"analyses\"", "\"bioproject\"", @@ -93,7 +93,7 @@ def test_csv(self, client, studies): "\"study_abstract\"", "\"study_name\"", "\"url\"" - ] + ]) first_row = [ "MGYS00000001", "", From d13789e1d1b352aab3ae345eb29ea0f4cca4d92b Mon Sep 17 00:00:00 2001 From: sandyr Date: Mon, 22 Jan 2024 13:58:22 +0000 Subject: [PATCH 23/24] restore quote string in csv values --- tests/api/test_study.py | 28 ++++++++++++++-------------- 1 file changed, 14 insertions(+), 14 deletions(-) diff --git a/tests/api/test_study.py b/tests/api/test_study.py index b1344f4f4..49ac8e3e6 100644 --- a/tests/api/test_study.py +++ b/tests/api/test_study.py @@ -95,22 +95,22 @@ def test_csv(self, client, studies): "\"url\"" ]) first_row = [ - "MGYS00000001", - "", - "PRJDB0001", - "Centre Name", - "HARVESTED", - "", + "\"MGYS00000001\"", + "\"\"", + "\"PRJDB0001\"", + "\"Centre Name\"", + "\"HARVESTED\"", + "\"\"", "False", None, - "", - "", - "", - "", - "SRP0001", - "", - "Example study name 1", - "http://testserver/v1/studies/MGYS00000001.csv" + "\"\"", + "\"\"", + "\"\"", + "\"\"", + "\"SRP0001\"", + "\"\"", + "\"Example study name 1\"", + "\"http://testserver/v1/studies/MGYS00000001.csv\"" ] rows = content.splitlines() From d23c962a8299f644730f11d8209048d2bc307f13 Mon Sep 17 00:00:00 2001 From: sandyr Date: Mon, 22 Jan 2024 15:06:54 +0000 Subject: [PATCH 24/24] 2.4.44 --- emgcli/__init__.py | 2 +- pyproject.toml | 2 +- 2 files changed, 2 insertions(+), 2 deletions(-) diff --git a/emgcli/__init__.py b/emgcli/__init__.py index bd355a7c0..57d8f469a 100644 --- a/emgcli/__init__.py +++ b/emgcli/__init__.py @@ -1 +1 @@ -__version__: str = "2.4.43" +__version__: str = "2.4.44" diff --git a/pyproject.toml b/pyproject.toml index 5e0a68b74..cd268fd7b 100644 --- a/pyproject.toml +++ b/pyproject.toml @@ -117,7 +117,7 @@ max-line-length = 119 """ [tool.bumpversion] -current_version = "2.4.43" +current_version = "2.4.44" [[tool.bumpversion.files]] filename = "emgcli/__init__.py"