diff --git a/.gitignore b/.gitignore index 1e5f0521..aa38c136 100644 --- a/.gitignore +++ b/.gitignore @@ -1,5 +1,20 @@ +*.tmp +reports +src/ontology/oort +src/ontology/reports +src/ontology/imports +src/ontology/mirror/* +src/ontology/cmpo.obo +src/ontology/cmpo.owl +src/ontology/cmpo-simple.owl +semantic.cache .DS_Store +*~ oldfiles* Dropbox - Shortcut.lnk patterns.docx -imports/* +.dropbox +cmpo-composer +paper-stats.xlsx +webulous_submissions +zooma \ No newline at end of file diff --git a/README.md b/README.md index 792649e4..b0059f8d 100644 --- a/README.md +++ b/README.md @@ -1,3 +1,5 @@ +[![DOI](https://zenodo.org/badge/13996/obophenotype/cmpo.svg)](https://zenodo.org/badge/latestdoi/13996/obophenotype/cmpo) + CMPO ==== @@ -22,11 +24,20 @@ Apache License, version 2.0. ### GitHub Files ### -* __release/cmpo.obo__ +* __cmpo.obo__ * A simple OBO formatted released of CMPO -* __release/cmpo-simple.owl__ +* __cmpo-simple.owl__ * A simple OWL formatted version of CMPO, pre-reasoned and exludes logical axioms. -* __release/cmpo.owl__ +* __cmpo.owl__ * An OWL formatted version of CMPO, pre-reasoned and includes logial axioms. (GO/PATO terms imported using MIREOT) -* __src/cmpo.owl__ +* __src/ontology/cmpo-edit.owl__ * This is the source file for CMPO editors. It includes all logical axioms and imports the Gene Ontology and PATO. (NOTE: If you unpack the imports.tar.gz file and open cmpo.owl in Protege, the Protege will import GO and PATO from your file system rather than pulling form the web) + +### Previous releases + +Previous releases are available from this repository, see the [releases](releases tab). +Editors of this ontology should use the edit version, [src/ontology/cmpo-edit.owl](src/ontology/cmpo-edit.owl) + +## Acknowledgements + +This ontology repository was created using the [ontology starter kit](https://github.com/INCATools/ontology-starter-kit) diff --git a/cmpo-simple.owl b/cmpo-simple.owl index c177b60a..8941ade8 100644 --- a/cmpo-simple.owl +++ b/cmpo-simple.owl @@ -13,7 +13,7 @@ xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:obo="http://purl.obolibrary.org/obo/"> - + diff --git a/cmpo.obo b/cmpo.obo index a2718815..7134ac18 100644 --- a/cmpo.obo +++ b/cmpo.obo @@ -1,5 +1,5 @@ format-version: 1.2 -data-version: http://www.ebi.ac.uk/cmpo/releases/2017-12-18/cmpo.obo +data-version: http://www.ebi.ac.uk/cmpo/releases/2017-12-19/cmpo.obo subsetdef: cmpo "CMPO subset" subsetdef: goantislim_grouping "Grouping classes that can be excluded" subsetdef: gocheck_do_not_annotate "Term not to be used for direct annotation" diff --git a/cmpo.owl b/cmpo.owl index 2c738c23..4c8a42cb 100644 --- a/cmpo.owl +++ b/cmpo.owl @@ -14,7 +14,7 @@ xmlns:obo="http://purl.obolibrary.org/obo/" xmlns:dc="http://purl.org/dc/elements/1.1/"> - + Simon Jupp Johan Lundin Claudia Lukas diff --git a/imports.tar.gz b/imports.tar.gz index 6c93b55b..7f250024 100644 Binary files a/imports.tar.gz and b/imports.tar.gz differ diff --git a/release/cmpo-simple.owl b/release/cmpo-simple.owl deleted file mode 100644 index d8c9fc48..00000000 --- a/release/cmpo-simple.owl +++ /dev/null @@ -1,38712 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - definition source - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - cmpo - CMPO subset - - - - - - - - - Grouping classes that can be excluded - - - - - - - - - Term not to be used for direct annotation - - - - - - - - - Term not to be used for direct manual annotation - - - - - - - - - Aspergillus GO slim - - - - - - - - - Candida GO slim - - - - - - - - - ChEMBL protein targets summary - - - - - - - - - Generic GO slim - - - - - - - - - GOA and proteome slim - - - - - - - - - Metagenomics GO slim - - - - - - - - - PIR GO slim - - - - - - - - - Plant GO slim - - - - - - - - - Fission yeast GO slim - - - - - - - - - synapse GO slim - - - - - - - - - Viral GO slim - - - - - - - - - Yeast GO slim - - - - - - - - - Prokaryotic GO subset - - - - - - - - - Catalytic activity terms in need of attention - - - - - - - - - Systematic synonym - - - - - - - - - - Terms created by TermGenie that do not follow a template and require additional vetting by editors - - - - - - - - - Viral overhaul terms - - - - - - - - - - - - - - - subset_property - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - has_alternative_id - - - - - - - - has_broad_synonym - - - - - - - - database_cross_reference - - - - - - - - has_exact_synonym - - - - - - - - has_narrow_synonym - - - - - - - - has_obo_namespace - - - - - - - - has_related_synonym - - - - - - - - has_scope - - - - - - - - - - - - - - in_subset - - - - - - - - shorthand - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - part_of - BFO:0000050 - OBO_REL:part_of - part_of - - - - - - - - - - has_part - - - - - - - - - - occurs in - BFO:0000066 - external - occurs_in - occurs_in - - - - - - - - - towards - Relation binding a relational quality or disposition to the relevant type of entity. - quality - towards - - - - - - - - - inheres_in - - - - - - - - - - bearer of - - - - - - - - - participates in - - - - - - - - - happens_during - RO:0002092 - external - happens_during - happens_during - - - - - - - - - - ends_during - RO:0002093 - ends_during - ends_during - external - - - - - - - - - regulates - RO:0002211 - external - regulates - regulates - - - - - - - - - - negatively regulates - RO:0002212 - external - negatively_regulates - negatively_regulates - - - - - - - - - - - positively regulates - RO:0002213 - external - positively_regulates - positively_regulates - - - - - - - - - - - transports or maintains localization of - - - - - - - - has target end location - - - - - - - - - decreased_in_magnitude_relative_to - This relation is used to determine the 'directionality' of relative qualities such as 'decreased strength', relative to the parent type, 'strength'. - decreased_in_magnitude_relative_to - q1 decreased_in_magnitude_relative_to q2 if and only if magnitude(q1) < magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale. - quality - - - - - PATOC:CJM - q1 decreased_in_magnitude_relative_to q2 if and only if magnitude(q1) < magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale. - - - - - - - - - - different_in_magnitude_relative_to - different_in_magnitude_relative_to - q1 different_in_magnitude_relative_to q2 if and only if magnitude(q1) NOT =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale. - quality - - - - PATOC:CJM - q1 different_in_magnitude_relative_to q2 if and only if magnitude(q1) NOT =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale. - - - - - - - - - - directly_associated_with - 2009-08-26T02:50:08Z - Example: 'Lewy bodies increased number related to dystrophic neurite increased number' (from annotation of PMID:8740227 in http://ccdb.ucsd.edu/1.0/NDPO.owl#ndpo_404). Here the increase in the number of lewy bodies is directly_associated_with the increase in the number of dystrophic neurites. -Association is weaker than correlation or proportionality. These relations may be later added to PATO. - cjm - directly_associated_with - q1 directly_associated_with q2 iff q1 is dependent on q2, and the magnitude of q1 increases if the magnitude of q2 is increased, or the magnitude of q1 decreases if the magnitude of q2 is decreased. The relationship is not necessarily linear. - quality - - - - PATOC:cjm - Wikipedia:Association_(statistics) - q1 directly_associated_with q2 iff q1 is dependent on q2, and the magnitude of q1 increases if the magnitude of q2 is increased, or the magnitude of q1 decreases if the magnitude of q2 is decreased. The relationship is not necessarily linear. - - - - - - - - - - has_cross_section - Example: a spherical object has the quality of being spherical, and the spherical quality has_cross_section round. - has_cross_section - quality - s3 has_cross_section s3 if and only if : there exists some 2d plane that intersects the bearer of s3, and the impression of s3 upon that plane has shape quality s2. - - - - PATOC:CJM - s3 has_cross_section s3 if and only if : there exists some 2d plane that intersects the bearer of s3, and the impression of s3 upon that plane has shape quality s2. - - - - - - - - - - has_dividend_quality - has_dividend_quality - quality - - - - - - - - - - has_divisor_quality - has_divisor_quality - quality - - - - - - - - - - has_ratio_quality - has_ratio_quality - quality - - - - - - - - - - increased_in_magnitude_relative_to - This relation is used to determine the 'directionality' of relative qualities such as 'increased strength', relative to the parent type, 'strength'. - increased_in_magnitude_relative_to - q1 increased_in_magnitude_relative_to q2 if and only if magnitude(q1) > magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale. - quality - - - - - PATOC:CJM - q1 increased_in_magnitude_relative_to q2 if and only if magnitude(q1) > magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale. - - - - - - - - - - inversely_associated_with - 2009-08-26T02:50:24Z - Association is weaker than correlation or proportionality. These relations may be later added to PATO. - cjm - inversely_associated_with - q1 inversely_associated_with q2 iff q1 is dependent on q2, and the magnitude of q1 decreases if the magnitude of q2 is increased, or the magnitude of q1 increases if the magnitude of q2 is decreased. The relationship is not necessarily linear. - quality - - - - PATOC:cjm - Wikipedia:Association_(statistics) - q1 inversely_associated_with q2 iff q1 is dependent on q2, and the magnitude of q1 decreases if the magnitude of q2 is increased, or the magnitude of q1 increases if the magnitude of q2 is decreased. The relationship is not necessarily linear. - - - - - - - - - - reciprocal_of - There are frequently two ways to state the same thing: we can say 'spermatocyte lacks asters' or 'asters absent from spermatocyte'. In this case the quality is 'lacking all parts of type' - it is a (relational) quality of the spermatocyte, and it is with respect to instances of 'aster'. One of the popular requirements of PATO is that it continue to support 'absent', so we need to relate statements which use this quality to the 'lacking all parts of type' quality. - q1 reciprocal_of q2 if and only if : q1 and q2 are relational qualities and a phenotype e q1 e2 mutually implies a phenotype e2 q2 e. - quality - reciprocal_of - - - - PATOC:CJM - q1 reciprocal_of q2 if and only if : q1 and q2 are relational qualities and a phenotype e q1 e2 mutually implies a phenotype e2 q2 e. - - - - - - - - - - similar_in_magnitude_relative_to - q1 similar_in_magnitude_relative_to q2 if and only if magnitude(q1) =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale. - quality - similar_in_magnitude_relative_to - - - - PATOC:CJM - q1 similar_in_magnitude_relative_to q2 if and only if magnitude(q1) =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale. - - - - - - - - - - has accuracy - - - - - - - - has qualifier - - - - - - - - - - - - - cell population phenotype - - CMPO:0000002 - A quality that that inheres in a population of cells - cell population phenotype - - - - - - - - - cellular phenotype - A quality that inheres in or specifically depends on a cellular process, a cell population, a whole cell or a subcellular structure. - cellular phenotype - - - - - - - - - cell morphology phenotype - - - CMPO:0000005 - A collection of qualities that inhere in the whole cell relating to the cell's shape, size or structure - cell morphology - - - - - - - - - cell process phenotype - - A quality that inheres in a cellular process - CMPO:0000007 - cell physiology phenotype - cell process phenotype - - - - - - - - - cell component number phenotype - - An increase or decrease in the number of specified components within a cell - CMPO:0000008 - cell component number - - - - - - - - - cell component size phenotype - - A collection of size qualities that inhere in a cellular component - CMPO:0000010 - cell component size - - - - - - - - - cell component shape phenotype - - A collection of shape qualities that inhere in a cellular component - CMPO:0000011 - cell component shape - - - - - - - - - cell component structure phenotype - - CMPO:0000012 - A collection of structure qualities that inhere in a cellular component - cell component structure - - - - - - - - - cell viability phenotype - - CMPO:0000013 - A phenotype relating to the ability of a cell survive or to develop normally - cell viability - - - - - - - - - viable cell phenotype - - CMPO:0000014 - A cell phenotype where the cell is viable - viable cell - - - - - - - - - inviable cell phenotype - - CMPO:0000015 - A cell phenotype where the cell is not viable - inviable cell - - - - - - - - - cell nucleation phenotype - - CMPO:0000016 - A nucleation quality that inheres in the whole cell - cell nucleation - - - - - - - - - mononuclear cell phenotype - - CMPO:0000017 - mononuclear cell - - - - - - - - - multinucleated cell phenotype - - CMPO:0000018 - A multinucleate quality that inheres in a cell - polynuclear cell - multinucleated cell - - - - - - - - - cytoskeletal phenotype - - A collection of qualities that inhere in any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice. - CMPO:0000020 - cytoskeletal phenotype - - - - - - - - - endoplasmic reticulum phenotype - - CMPO:0000021 - A collection of qualities that inhere in any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. - endoplasmic reticulum phenotype - - - - - - - - - golgi phenotype - - CMPO:0000022 - A collection of qualities that inhere in any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack - golgi phenotype - - - - - - - - - mitochondrion phenotype - - A collection of qualities that inhere in any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. - mitochondrial part phenotype - CMPO:0000023 - mitochondrion phenotype - - - - - - - - - nuclear phenotype - - CMPO:0000024 - A collection of qualities that inhere in any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. - nuclear phenotype - - - - - - - - - organelle shape phenotype - - A collection of qualities that inhere in a cellular organelle relating to the organelle's shape - CMPO:0000026 - organelle shape - - - - - - - - - nucleus shape phenotype - - - nuclear shape - A collection of qualities that inhere in the nucleus relating to the ratios of distances between its features (points, edges, surfaces and also holes etc). - - - - - - - - - cell adhesion phenotype - - A phenotype where the attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules is observed - CMPO:0000028 - cell adhesion phenotype - - - - - - - - - cell cycle phenotype - - CMPO:0000029 - A collection of qualities that inhere the cell cycle - cell cycle phenotype - - - - - - - - - cell death phenotype - - CMPO:0000030 - A phenotype where the cell death process process is observed - PMID:20360735 - cell death phenotype - - - - - - - - - cell membrane organisation phenotype - - A phenotype observation of a process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. - CMPO:0000032 - cell membrane organisation phenotype - - - - - - - - - cell migration phenotype - - PMID:20360735 - A phenotype of a cell involving its translation from one location to another - CMPO:0000033 - cell migration phenotype - - - - - - - - - cell growth phenotype - - A phenotype observation of the process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. - CMPO:0000035 - cell growth phenotype - - - - - - - - - chromosome segregation phenotype - - A phenotype observation of the process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the alignment of chromosomes at the metaphase plate, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. - CMPO:0000036 - chromosome segregation phenotype - - - - - - - - - metabolic process phenotype - - CMPO:0000037 - A phenotype observation of chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. - metabolic process phenotype - - - - - - - - - organelle localization phenotype - - A phenotype observations where any process in which an organelle is transported to, and/or maintained in, a specific location. - CMPO:0000038 - organelle localization phenotype - - - - - - - - - regulation of metabolic process phenotype - - A phenotype observation where a process modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. - CMPO:0000039 - regulation of metabolic process phenotype - - - - - - - - - regulation of signal transduction phenotype - - A phenotype observation of a process that modulates the frequency, rate or extent of signal transduction. - CMPO:0000040 - regulation of signal transduction phenotype - - - - - - - - - transport phenotype - - A phenotype observation of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. - CMPO:0000041 - transport phenotype - - - - - - - - - increased cell component number phenotype - - An increased number of specified cellular components relative to normal - CMPO:0000042 - increased cell component number - - - - - - - - - decreased cell component number phenotype - - CMPO:0000043 - A decrease in number of specified cellular components relative to normal - decreased cell component number - - - - - - - - - apoptotic DNA fragmentation phenotype - - A phenotype observation where the cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments. - apoptotic DNA - CMPO:0000047 - apoptotic DNA fragmentation - - - - - - - - - apoptotic cell shape phenotype - - - apoptotic cell shape - dispersed outline with blobby protrusions - CMPO:0000048 - A phenotype observation at the level of the cell shape where the cell is apoptotic - - - - - - - - - aggregated cells in population - - cell aggregates - cell islands - CMPO:0000049 - aggregated cells - Groups of cells gathered or tending to gather into a mass or whole. - aggregated cells in population - clustered cells - - - - - - - - - altered cell number in population - - Number of cells in a population phenotype - CMPO:0000050 - cell number in population - - - - - - - - - increased cell numbers - - The population has an increased number of cells with respect to normal - CMPO:0000051 - increased cell numbers - - - - - - - - - decreased cell numbers - - CMPO:0000052 - reduced cell numbers - decreased cells - fewer cells - The population has a decreased number of cells with respect to normal - decreased cell numbers - less cells - - - - - - - - - more cells in S - - CMPO:0000053 - increased number of cells in S phase mitosis - - - - - - - - - cell population phenotype by process - - A population of cells where a specifcied biological process is occuring or is observed. - CMPO:0000054 - cell population process - - - - - - - - - more cells in G1 - - CMPO:0000055 - increased cell numbers in G1 - - - - - - - - - more cells in G2M - - increased number of cells in G2M - increased mitotic index - CMPO:0000056 - - - - - - - - - fewer cells in G1 - - CMPO:0000057 - decreased number of cells in G1 phase - less cells in G1 - - - - - - - - - fewer cells in G2M - - less cells in G2M - decreased mitotic index - CMPO:0000058 - decreased number of cells in G2M phase - - - - - - - - - fewer cells in S - - decreased number of cells in S phase - CMPO:0000059 - decreased number of cells in S - less cells in S - - - - - - - - - decreased number of focal adhesion phenotype - - decreased focal adhesion abundance - A phenotype observation at the level of focal adhesions where the components number has decreased. - CMPO:0000063 - decreased number of focal adhesion - - - - - - - - - centrally located focal adhesion phenotype - - PMID:19667130 - CMPO:0000064 - A phenotype observation where the focal adhesion is located in a position equidistant from the edges of the cell - centrally located focal adhesion - - - - - - - - - cell component position phenotype - - CMPO:0000065 - A phenotype observation at the level of a cellular component relating to the components position in the cell - cell component position - - - - - - - - - peripheral focal adhesion phenotype - - CMPO:0000066 - PMID:19667130 - A phenotype observation where the focal adhesions's position is at the edge or boundary of a related entity. - peripheral focal adhesion - - - - - - - - - decreased number of filopodia phenotype - - A phenotype observation at the level of filopodia where the components number has decreased. - CMPO:0000067 - decreased number of filopodia - fewer filopodia - - - - - - - - - decreased number of microtubules phenotype - - fewer microtubules - CMPO:0000068 - A phenotype observation at the level of microtubules where the components number has decreased. - decreased number of microtubules - - - - - - - - - decreased number of dendritic branches phenotyope - - CMPO:0000069 - A phenotype observation at the level of dendritic branches where the components number has decreased. - - - - - - - - - cell with projections - - PMID:20531400 - CMPO:0000071 - Single cell with protrusions - cell with protrusions - - - - - - - - - increased number of cell projections phenotype - - An increase in number of any cell projection relative to normal - CMPO:0000072 - increased number of cell projections - - - - - - - - - more cells with projections - - CMPO:0000073 - increased number of cells in population with projections - - - - - - - - - decreased number of cell projections phenotype - - A phenotype observation at the level of cell projections where the components number has decreased. - CMPO:0000074 - decreased number of cell projections - - - - - - - - - fewer cells with projections - - CMPO:0000075 - decreased number of cells in population with projections - - - - - - - - - increased number of filopodia - - CMPO:0000076 - more filopodia - A phenotype observation at the level of filopodia where the components number has increased. - - - - - - - - - elongated cell phenotype - - - A phenotype observation at the level of the cell shape where the cell is elongated, with a length notably greater than its width - CMPO:0000077 - bipolar cell - elongated cell - - - - - - - - - elongated cells in population - - - Cells in population with a length notably greater than their width - PMID:21893601; PMID:20531400 - CMPO:0000078 - elongated cells in population - - - - - - - - - increased number of lamellipodia phenotype - - A phenotype observation at the level of lamellipodia where the components number has increased. - CMPO:0000080 - increased number of lamellipodia - lamellipodium phenotype - - - - - - - - - decreased number of lamellipodia phenotype - - A phenotype observation at the level of lamellipodia where the components number has decreased. - CMPO:0000081 - decreased number of lamellipodia - - - - - - - - - more lamellipodia cells - - CMPO:0000083 - increased lamellipodia cells in population phenotype - - - - - - - - - fewer lamellipodia cells - - CMPO:0000084 - decreased lamellipodia cells in population phenotype - - - - - - - - - cell ploidy phenotype - - A phenotype observation at the level of the whole cell relating to the cell's ploidy - CMPO:0000085 - cell ploidy - - - - - - - - - polyploid cell phenotype - - CMPO:0000086 - A cell phenotype with more than two homologous sets of chromosomes. - polyploid cell - - - - - - - - - S phase mitotic phenotype - - - CMPO:0000087 - A phenotype observation at the level of athe S phase of the mitotic cell cycle - S phase mitotic phenotype - - - - - - - - - G1 phase mitotic phenotype - - - A phenotype observation at the level of a G1 phase of the mitotic cell cycle - CMPO:0000088 - G1 phase mitotic phenotype - - - - - - - - - G2/M transition phenotype - - CMPO:0000089 - A phenotype observation at the level of the G2/M transition of the mitotic cell cycle - G2/M transition phenotype - - - - - - - - - cell cycle phase phenotype - - A phenotype observation at the level of a cell cycle phase - CMPO:0000090 - cell cycle phase phenotype - - - - - - - - - more polyploid cells - - CMPO:0000091 - increased number of polyploid cells in population - - - - - - - - - increased number of focal adhesion phenotype - - A phenotype observation at the level of focal adhesions where the components number has increased. - increased focal adhesion abundance - CMPO:0000092 - increased number of focal adhesion - - - - - - - - - increased number of nucleoli phenotype - - CMPO:0000093 - A phenotype observation at the level of nucleoli where the components number has increased. - increased number of nucleoli - - - - - - - - - decreased number of nucleoli phenotype - - CMPO:0000094 - A phenotype observation at the level of nucleoli where the components number has decreased. - decreased number of nucleoli - - - - - - - - - more cells with decreased number of nucleoli - - CMPO:0000095 - more cells with decreased number of nucleoli - - - - - - - - - more cells with increased number of nucleoli - - CMPO:0000096 - increased number of nucleoli in population phenotype - - - - - - - - - increased number of microtubules phenotype - - A phenotype observation at the level of microtubules where the components number has increased. - more microtubules - CMPO:0000097 - increased number of microtubules - - - - - - - - - phagosomes phenotype - - phagosomes present phenotype - A phenotype observation at the level of the phagosomes, a membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis. - CMPO:0000102 - phagosomes - - - - - - - - - phagosomes absent phenotype - - - A phenotype observation where phagosomes are absent - CMPO:0000103 - phagosomes absent - - - - - - - - - actin filament phenotype - - A phenotype observation at the level of the actin filaments, a filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. - CMPO:0000104 - actin filament phenotype - - - - - - - - - increased number of actin filament phenotype - - - A phenotype observation at the level of actin filaments where the components number has increased. - more actin - CMPO:0000105 - PMID:20531400 - more total actin - PMID: 21893601 - actin fiber cells - increased number of actin filament - - - - - - - - - decreased number of actin filament phenotype - - - A phenotype observation at the level of actin filaments where the components number has decreased. - PMID: 21893601 - CMPO:0000106 - less total actin - less actin - decreased number of actin filament - - - - - - - - - more actin filament cells - - CMPO:0000107 - increased number of actin filament cells in population - - - - - - - - - fewer actin filament cells - - decreased number of actin filament cells - CMPO:0000108 - decreased number of actin filament phenotypes in population - - - - - - - - - centered cytoskeleton phenotype - - - CMPO:0000109 - A phenotype observation where the cytoskeleton is located in a position equidistant from the edges of the cell - centered cytoskeleton - - - - - - - - - centered nucleus phenotype - - - CMPO:0000110 - A phenotype observation where the nucleus is located in a position equidistant from the edges of the cell - centered nucleus - - - - - - - - - dispersed nucleus phenotype - - - CMPO:0000111 - A phenotype observation where the nucleus is distributed or spread over a considerable extent. - dispersed nucleus - - - - - - - - - apoptopic nucleus phenotype - - - CMPO:0000112 - A phenotype observation at the level of nucleus consisting of blebbing of the nucleus and DNA fragmentation due to the cell undergoing a specific form of programmed cell death termed apoptosis. - apoptopic nucleus - - - - - - - - - deformed nucleus - - A phenotype observation where the nucleus is distorted in form - CMPO:0000113 - - - - - - - - - peripheral nucleus phenotype - - - A phenotype observation where the nucleus's position is at the edge or boundary of a related entity. - CMPO:0000114 - peripheral nucleus - - - - - - - - - peripheral cytoskeleton phenotype - - - CMPO:0000115 - A phenotype observation where the cytoskeleton's position is at the edge or boundary of a related entity. - peripheral cytoskeleton - - - - - - - - - abnormal cell shape phenotype - - - CMPO:0000116 - A phenotype observation at the level of the cell shape where the shape is abnormal - abnormal cell shape - - - - - - - - - bilobed nucleus phenotype - - bilobed - CMPO:0000117 - A lobed quality inhering in a nucleus by virtue of the nucleus being divided into or having two lobes. - bilobed nucleus - - - - - - - - - round cell phenotype - - - circular cell - PMID:21893601 - not spreading cell - CMPO:0000118 - spherical cell - A phenotype observation at the level of the cell shape where the cell is round - low eccentricity cell - round cell - - - - - - - - - elongated focal adhesion - - CMPO:0000119 - A phenotype observation of the length of the focal adhesion is notably higher than the width. - long focal adhesion - - - - - - - - - elongated nucleus - - long nucleus - A phenotype observation of the length of the nucleus is notably higher than the width. - CMPO:0000120 - - - - - - - - - arrow shaped cell phenotype - - - CMPO:0000121 - A phenotype observation at the level of the cell shape where the cell is arrow shaped, with a wide front and a sharp tail, displaying monopolar cell growth - triangular shaped cell - - - - - - - - - triangular shaped cell phenotype - - - CMPO:0000122 - A phenotype observation at the level of the cell shape where the cell has a triangular shape, with a wide front and a sharp tail, displaying cell motility - arrow shaped cell - triangular shaped cell - - - - - - - - - round nucleus phenotype - - round nucleus - circular nucleus - CMPO:0000123 - A phenotype observation where the shape of the nucleus has every part of the surface or the circumference equidistant from the center. - round nucleus - - - - - - - - - nuclear body phenotype - - A phenotype observation at the level of the nuclear body, an extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. - CMPO:0000125 - nuclear body - - - - - - - - - increased nuclear body size phenotype - - - - CMPO:0000126 - A phenotype observation where the nuclear body size is relatively high. - PMID:22884692 - increased nuclear body size - - - - - - - - - decreased nuclear body size phenotype - - - - CMPO:0000127 - PMID:22884692 - A phenotype observation where the nuclear body size is relatively low. - decreased nuclear body size - - - - - - - - - increased cell size phenotype - - - CMPO:0000128 - A phenotype observation at the level of the cell size where a cell is larger with respect to normal/wild-type - increased cell area - PMID:20531400 - large cell - big cell - increased cell size - - - - - - - - - decreased cell size phenotype - - - CMPO:0000129 - A phenotype observation at the level of the cell size where a cell is smaller with respect to normal/wild-type - small cell - - - - - - - - - decreased golgi volume phenotype - - CMPO:0000130 - A phenotype observation at the level of the golgi where the golgi's volume has decreased. - decreased golgi volume - - - - - - - - - increased golgi volume phenotype - - A phenotype observation at the level of the golgi where the golgi's volume has increased. - CMPO:0000131 - increased golgi volume - - - - - - - - - decreased cilium length phenotype - - - CMPO:0000132 - A phenotype observation at the level of a cilium where the components length has decreased. - decreased cilium length - - - - - - - - - increased cilium length phenotype - - - A phenotype observation at the level of a cilium where the components length has increased. - CMPO:0000133 - increased cilium length - - - - - - - - - decreased size of focal adhesion phenotype - - CMPO:0000134 - A phenotype observation where the size of the focal adhesion has decreased. - decreased size of focal adhesion - - - - - - - - - increased size of focal adhesion phenotype - - A phenotype observation where the size of the focal adhesion has increased. - CMPO:0000135 - increased size of focal adhesion - - - - - - - - - decreased focal adhesion area phenotype - - pmid:19667130 - CMPO:0000136 - small focal adhesion - A phenotype observation where the area of the focal adhesion has decreased. - decreased focal adhesion area - - - - - - - - - increased focal adhesion area phenotype - - large focal adhesion - A phenotype observation where the area of the focal adhesion has increased. - CMPO:0000137 - pmid:19667130 - increased focal adhesion area - - - - - - - - - decreased focal adhesion length phenotype - - CMPO:0000138 - decreased focal adhesion length - pmid:19667130 - short focal adhesion - A phenotype observation where the length of the focal adhesion has decreased. - - - - - - - - - increased focal adhesion length phenotype - - A phenotype observation where the length of the focal adhesion has increased. - CMPO:0000139 - increased focal adhesion length - - - - - - - - - increased nucleus size phenotype - - - large nucleus - increased DNA area - PMID:20531400 - A phenotype observation where the size of the nucleus has increased - large nuclei - PMID:20360735 - CMPO:0000140 - increased nucleus size - - - - - - - - - decreased nucleus size phenotype - - - PMID:21893601 - CMPO:0000141 - decreased nucleus size - small nucleus - decreased DNA area - A phenotype observation where the size of the nucleus has decreased - PMID:20360735 - - - - - - - - - increased nuclei size in G1 phenotype - - - - - - - - - - - - - - - - - - - - - - - - A phenotype of a cell that has both an increased nuclei size phenotypes and a G1 phase phenotype - CMPO:0000143 - increased nuclei size in G1 - - - - - - - - - decreased nuclei size in G1 phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - CMPO:0000144 - A phenotype of a cell that has both a decreased nuclei size phenotypes and a G1 phase phenotype - decreased nuclei size in G1 - small nuclei in G1 - - - - - - - - - increased thickness of dendritic branches phenotype - - A phenotype observation where the thickness of the dendritic branches has increased. - CMPO:0000145 - increased thickness of dendritic branches - - - - - - - - - decreased thickness of dendritic branches - - CMPO:0000146 - A phenotype observation where the thickness of the dendritic branches has decreased. - - - - - - - - - disorganized microtubules phenotype - - - pmid:21893601 - microtubule disorganised - A phenotype observation where the microtublue structure is disorganised - CMPO:0000147 - disorganized microtubules - - - - - - - - - podosome phenotype - - A phenotype observation at the level of podosomes, an actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell. - CMPO:0000148 - podosome - - - - - - - - - radial cytoskeleton phenotype - - - CMPO:0000149 - A phenotype observation where the cytoskeleton is symmetric, having equal proportions around a central point or axis. - radial cytoskeleton - - - - - - - - - organelle phenotype - - Phenotype observation organised by specific named organelles. - CMPO:0000150 - - - - - - - - - fragmented endoplasmic reticulum phenotype - - broken endoplasmic reticulum - A phenotype observation where the structure of the endoplasmic reticulum is fragmented or broken. - CMPO:0000151 - fragmented endoplasmic reticulum - - - - - - - - - fragmented golgi phenotype - - broken golgi - A phenotype observation at the level of the golgi where the golgi's structure is broken - CMPO:0000152 - broken golgi phenotype - fragmented golgi - - - - - - - - - fragmented mitochondria phenotype - - broken mitochondria - A phenotype observation where the structure of the mitochondria is fragmented or broken. - CMPO:0000153 - fragmented mitochondria - - - - - - - - - bright nuclei phenotype - - PMID:20531400 - CMPO:0000154 - A phenotype observation where the nuclear's color brightness is relatively high. - bright nuclei - - - - - - - - - fragmented nucleus phenotype - - - A phenotype observation where the structure of the nucleus is fragmented or broken. - broken nucleus - CMPO:0000155 - fragmented nucleus - - - - - - - - - graped micronucleus phenotype - - A phenotype observation where nuclear envelopes form around single chromosomes or small sets of chromosomes. Forming a grape like structure - CMPO:0000156 - pmid:20360735 - Mitocheck -Publication: http://www.ncbi.nlm.nih.gov/pubmed/20360735 -Micronucleation, i.e. presumably nuclear envelopes around single chromosomes or small sets of chromosomes. - grape - graped micronucleus - - - - - - - - - abnormal nucleus shape phenotype - - strange nuclear shape - abnormal nuclear shape - PMID:20360735 - A phenotype observation where the shape of the nucleus is abnormal - - - - - - - - - decreased nuclei size in G2/M phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - CMPO:0000158 - A phenotype observation at the level of the G2/M transition of the mitotic cell cycle where the nuclei are decreased in size with respect to normal - decreased nuclei size in G2/M - - - - - - - - - absence of cellular component phenotype - - CMPO:0000159 - A phenotype observation at the level of a cellular component where the cell component is absent - absence of cellular component - - - - - - - - - cell population viability phenotype - - CMPO:0000160 - cell viability in population phenotype - A phenotype of a cell population relating to the ability of the cells to live and develop normally - - - - - - - - - increased cell viability in population - - CMPO:0000161 - increased number of viable cell phenotype in a population - increased cell viability in population - - - - - - - - - decreased cell viability in population - - decreased cell viability in population - decreased number of viable cell phenotype in a population - CMPO:0000162 - - - - - - - - - cell population phenotype by morphology - - CMPO:0000163 - A population phenotype relating to the size, shape or structure of the cells within a population - cell population morphology - - - - - - - - - absence of cytokinesis phenotype - - - CMPO:0000164 - A phenotype that results in the absence of cytokinesis - absence of cytokinesis - - - - - - - - - cytokinesis phenotype - - - - A phenotype observation at the level of cytokinesis - CMPO:0000165 - cytokinesis phenotype - - - - - - - - - cell division phenotype - - CMPO:0000166 - A phenotype observation of the process resulting in the physical partitioning and separation of a cell into daughter cells. - cell division phenotype - - - - - - - - - increased rate of cell division phenotype - - faster cell division - A phenotype where the cell division process occurs at a higher rate - CMPO:0000168 - increased rate of cell division - - - - - - - - - decreased rate of cell division phenotype - - slower cell division - A phenotype where the cell division process occurs at a lower rate - CMPO:0000169 - decreased rate of cell division - - - - - - - - - telomerase activity phenotype - - CMPO:0000170 - A phenotype observation of the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence. - telomerase activity phenotype - - - - - - - - - decreased telomerase activity phenotype - - A phenotype observation where the occurane of telomerase activity is decreased - CMPO:0000171 - decreased telomerase activity - - - - - - - - - increased telomerase activity phenotype - - A phenotype observation where the occurane of telomerase activity is increased - CMPO:0000172 - increased telomerase activity - - - - - - - - - G0/1 arrested phenotype - - - CMPO:0000173 - (from GO) Under certain conditions, cells exit the cell cycle during G1 and remain in the G0 state as nongrowing, non-dividing (quiescent) cells. - A phenotype of a cell that is arrested at the G0/1 transition - G0/1 arrested - - - - - - - - - polarized endoplasmic reticulum phenotype - - polarized endoplasmic reticulum - A phenotype observation where the endoplasmic reticulum is oriented in the cell with extremities at either end of the main axis. - CMPO:0000174 - polarized endoplasmic reticulum - - - - - - - - - molecular component phenotype - - A quality that inheres in a molecular component of a cell - CMPO:0000175 - molecular component phenotype - - - - - - - - - cell DNA phenotype - - CMPO:0000176 - A phenotype observation at the level of the cell DNA - cell DNA phenotype - - - - - - - - - misshapen DNA - - This phenotype often results in a nucleus with an irregular shape phenotype. - A shape quality that inheres in a DNA molecule where the shape of the molecule is abnormal. - CMPO:0000177 - - - - - - - - - site of double-strand break phenotype - - A phenotype observation at the level of the site of double-strand break, a region of a chromosome at which a DNA double-strand break has occurred. - CMPO:0000180 - site of double-strand break - - - - - - - - - decreased number of site of double-strand break phenotype - - A phenotype observation at the level of double strand breaks where the components number has decreased. - CMPO:0000181 - decreased number of site of double-strand break - - - - - - - - - increased number of site of double-strand break phenotype - - A phenotype observation where the number of double-strand breaks has increased - CMPO:0000182 - increased number of site of double-strand break - - - - - - - - - cell-matrix adhesion phenotype - - CMPO:0000185 - cell-matrix adhesion phenotype - - - - - - - - - increased cell component size phenotype - - CMPO:0000186 - A phenotype observation at the level of a cellular component where the components size has increased. - increased cell component size - - - - - - - - - decreased cell component size phenotype - - CMPO:0000187 - A phenotype observation at the level of a cellular component where the components size has decreased. - decreased cell component size - - - - - - - - - cell spreading phenotype - - - - cell spreading phenotype - substrate adhesion-dependent cell spreading phenotype - A phenotype observation where the morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate. - CMPO:0000188 - - - - - - - - - cellular development phenotype - - CMPO:0000189 - A phenotype observation of a biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition. - cellular development phenotype - - - - - - - - - decreased number of axons phenotype - - A phenotype observation at the level of axons where the components number has decreased. - CMPO:0000190 - decreased number of axons - - - - - - - - - increased number of axons phenotype - - A phenotype observation at the level of axons where the components number has increased. - CMPO:0000191 - increased number of axons - - - - - - - - - mitotic process phenotype - - CMPO:0000194 - A phenotype observation at the level of the mitotic cell cycle - mitotic process phenotype - - - - - - - - - arrested process phenotype - - CMPO:0000195 - A phenotype of a cell where a particular process is arrested, or ends earlier in time than expected - arrested process - - - - - - - - - M phase arrested phenotype - - - mitosis incomplete process phenotype - CMPO:0000196 - mitotic arrest - A phenotype of a cell where the M phase of mitotic cell cycle process is arrested, or ends earlier in time than expected - M phase arrested - m phase arrest - - - - - - - - - mitosis delayed phenotype - - - CMPO:0000202 - A phenotype observation where mitosis is delayed - PMID:20360735 - Mitotic delay - mitosis delayed - - - - - - - - - G2 arrested phenotype - - - CMPO:0000203 - A phenotype of a cell is arrested in G2 pahse of the cell cycle. - G2 arrested - - - - - - - - - S phase arrested phenotype - - - CMPO:0000204 - A phenotype of a cell where the S phase process is arrested, or ends earlier in time than expected - S phase arrested - - - - - - - - - increased duration of exit from mitosis phenotype - - PMID:20711181 - increased duration of exit from mitosis - prolonged mitotic exit - A phenotype observation where the duration of the exit from mitosis is increased - CMPO:0000205 - - - - - - - - - decreased duration of exit from mitosis phenotype - - CMPO:0000206 - decreased duration of exit from mitosis - - - - - - - - - G2 phase mitotic phenotype - - - CMPO:0000207 - A phenotype observation at the level of a G2 phase of the mitotic cell cycle - G2 phase mitotic phenotype - - - - - - - - - mitotic metaphase phenotype - - - A phenotype observation at the level of the mitotic metaphase of the cell cycle - CMPO:0000208 - mitotic metaphase phenotype - - - - - - - - - more mitotic metaphase cells - - CMPO:0000210 - increased number of mitotic metaphase cells in population phenotype - - - - - - - - - fewer mitotic metaphase cells - - CMPO:0000211 - decreased number of mitotic metaphase cells in population phenotype - - - - - - - - - abnormal cell cycle phenotype - - CMPO:0000212 - abnormal cell cycle - altered level of protein in cell nucleus - A phenotype where the cell cycle is in some way abnormal - - - - - - - - - binuclear cell phenotype - - CMPO:0000213 - binuclear cell - nuclei stay close together - A phenotype observation where a cell is binucleate, e.g. have two nuclei per cell - - - - - - - - - increased duration of mitotic chromosome condensation phenotype - - CMPO:0000214 - A phenotype observation where the duration of the mitotic chromosome condensation is increased - increased duration of mitotic chromosome condensation - longer mitotic chromosome condensation - - - - - - - - - decreased duration of mitotic chromosome condensation phenotype - - CMPO:0000215 - A phenotype observation where the duration of the mitotic chromosome condensation is decreased - decreased duration of mitotic chromosome condensation - - - - - - - - - absence of mitotic chromosome decondensation phenotype - - - CMPO:0000216 - A phenotype resulting from the absence of mitotic chromosome decondensation - absence of mitotic chromosome decondensation - failure in decondensation - - - - - - - - - absence of mitotic process phenotype - - CMPO:0000217 - A phenotype resulting in the absence of mitotic process - absence of mitotic process - - - - - - - - - mitotic chromosome condensation phenotype - - CMPO:0000218 - A phenotype observation at the level of mitotic chromosome condensation - mitotic chromosome condensation phenotype - - - - - - - - - mitotic chromosome decondensation phenotype - - - CMPO:0000219 - A phenotype observation at the level of mitotic chromosome decondensation - mitotic chromosome decondensation - - - - - - - - - cell apoptosis phenotype - - A phenotype where the apoptosis process is observed - CMPO:0000220 - cell apoptosis phenotype - - - - - - - - - more apoptosis in population - - CMPO:0000221 - increased number of apoptosis phenotypes in population - - - - - - - - - less apoptosis in population - - CMPO:0000222 - decreased number of apoptosis phenotypes in population - - - - - - - - - increased axon thickness phenotype - - - A phenotype observation where the thickness of the axon has increased. - CMPO:0000223 - increased axon thickness - - - - - - - - - decreased axon thickness phenotype - - - A phenotype observation where the thickness of the axon has decreased. - CMPO:0000224 - decresed axon thickness - - - - - - - - - increased axon length phenotype - - - A phenotype observation at the level of a axon where the components length has increased. - CMPO:0000227 - increased axon length - - - - - - - - - decreased axon length phenotype - - - CMPO:0000228 - A phenotype observation at the level of a axon where the components length has decreased. - decreased axon length - - - - - - - - - plasma membrane fusion occurance phenotype - - cell fusion event - CMPO:0000229 - plasma membrane fusion occurance - - - - - - - - - increased rate of cell migration process phenotype - - PMID:20360735 - CMPO:0000232 - A phenotype where the cell migration process occurs at an increased rate, typically observed as a faster moving cell - increased rate of cell migration process - - - - - - - - - decreased rate of cell migration process phenotype - - A phenotype where the cell migration process occurs at an redcued rate, typically observed as a slower moving cell - CMPO:0000233 - decreased rate of cell migration process - decreased speed of cell migration - - - - - - - - - cell movement phenotype - - A phenotype observation at the level of the whole cell relating to the cell's movement - CMPO:0000234 - cell movement - - - - - - - - - increased cell movement phenotype - - A phenotype observation at the level of the cell movement where cell movement is increased - CMPO:0000235 - increased cell movement - - - - - - - - - increased cell movement speed - - increased cell migration speed - CMPO:0000236 - cell moves faster - A phenotype observation at the level of the cell movement where the cell moves faster than normal/wild type. - - - - - - - - - increased cell movement distance - - CMPO:0000237 - A phenotype observation at the level of the cell movement where the distance travelled by the cell is increased. The distance is measured as the euclidean distance between start and end point of the cell trajectory. - increased cell migration distance - cells cover a longer distance - - - - - - - - - decreased cell movement phenotype - - A phenotype observation at the level of the cell movement where cell movement is decreased - CMPO:0000238 - decreased cell movement - - - - - - - - - decreased cell movement distance - - cells cover a shorter distance - CMPO:0000239 - A phenotype observation at the level of the cell movement where the distance travelled by the cell is decreased. The distance is measured as the euclidean distance between start and end point of the cell trajectory. - - - - - - - - - decreased cell movement speed - - CMPO:0000240 - A phenotype observation at the level of the cell movement where the cell moves slower than normal/wild type. - cell moves slower - - - - - - - - - proliferating cells - - high cell number in population - increased proliferation - CMPO:0000241 - increased number of cells in population phenotype - - - - - - - - - actin-mediated cell contraction phenotype - - CMPO:0000243 - cell contraction - A phenotype of a cell contraction caused by an actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body. - actin-mediated cell contraction - - - - - - - - - cell component movement phenotype - - A phenotype where the directed, self-propelled movement of a cellular component without the involvement of an external agent such as a transporter or a pore is observed - CMPO:0000244 - cell component movement - - - - - - - - - cell secretion phenotype - - A phenotype observation of the controlled release of a substance by a cell. - CMPO:0000245 - cell secretion phenotype - - - - - - - - - increased rate of protein secretion - - enhanced protein secretion - PMID:22660414 - CMPO:0000246 - A phenotype observation where the rate of release of proteins from a cell is increased - - - - - - - - - decreased rate of protein secretion - - inhibition of protein secretion - A phenotype observation where the rate of release of proteins from a cell is decreased - CMPO:0000247 - - - - - - - - - nuclear morphology phenotype - - - CMPO:0000249 - A phenotype observation at the level of the nucleus relating to the nuclear morphology - nuclear morphology - - - - - - - - - golgi morphology phenotype - - - CMPO:0000250 - A phenotype observation at the level of the golgi relating to the golgi's morphology - golgi morphology - - - - - - - - - cilium phenotype - - A phenotype observation at the level of the cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. - CMPO:0000251 - cilium phenotype - - - - - - - - - cilium morphology phenotype - - - A phenotype observation at the level of a cilium relating to the components shape, size or structure - CMPO:0000252 - cilium morphology - - - - - - - - - single cell phenotype - - CMPO:0000258 - A quality that inherers in a single or whole cell. - single cell phenotype - - - - - - - - - cellular component phenotype - - A quality that inheres in the cellular component of a cell - CMPO:0000259 - cellular component phenotype - - - - - - - - - geometric cell phenotype - - CMPO:0000261 - A phenotype observation at the level of the cell shape where the cell has a geometric shape with straight edges - PMID:21893601 - geometric cell - request geometric shape in pato - - - - - - - - - apoptotic DNA - - CMPO:0000262 - Fragmented and condensed DNA during or following apoptosis - apoptotic DNA - - - - - - - - - more cells in M phase - - CMPO:0000263 - Increased occurrence of mitotic cells - increased number of mitotic cells - increased occurrence of mitosis - - - - - - - - - fewer cells in M phase - - less cells in M phase - decreased occurrence of mitosis - decreased number of cell in mitosis - decreased occurrence of mitotic cells in population - CMPO:0000264 - decreased number of mitotic cells - - - - - - - - - M phase mitotic phenotype - - - CMPO:0000265 - A phenotype observation at the level of the M phase of the mitotic cell cycle - M phase mitotic phenotype - - - - - - - - - asymmetric lamellipodia phenotype - - - PMID:21893601 - A phenotype observation where more lamellipoda is localised to one side of the cell with respect to the other - asymmetric lamellae - CMPO:0000266 - asymmetric lamellipodia - - - - - - - - - star shaped cell phenotype - - - PMID:21893601 - CMPO:0000267 - spiky cell - A phenotype observation at the level of the cell shape where the cell has a star-like or bristly shape - star shaped cell - - - - - - - - - spiny shaped cell phenotype - - - PMID:21893601 - CMPO:0000268 - A phenotype observation at the level of the cell shape where the cell has a star-like or bristly shape - spiny shaped cell - - - - - - - - - increased variability of cell size in population - - A population of cells where the cells exhibit a high variability of size - CMPO:0000269 - variable cell size - - - - - - - - - increased variability of cell shape in population - - variable cell shape - A population of cells where the cells exhibit a high variability of shape - CMPO:0000270 - - - - - - - - - cortical actin cytoskeleton phenotype - - A phenotype observation at the level of the cortical actin cytoskeleton, the portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane. - peripheral actin phenotype - CMPO:0000271 - cortical actin cytoskeleton phenotype - - - - - - - - - increased cortical actin cytoskeleton mass phenotype - - A phenotype observation at the level of the cortical actin cytoskeleton where the components mass has increased. - increased cortical actin cytoskeleton mass - increased peripheral actin - PMID:21893601 - CMPO:0000272 - - - - - - - - - decreased cortical actin cytoskeleton mass phenotype - - PMID:21893601 - CMPO:0000273 - A phenotype observation at the level of the cortical actin cytoskeleton where the components mass has decreased. - decreased cortical actin cytoskeleton mass - decreased peripheral actin - - - - - - - - - disorganised cortical actin cytoskeleton phenotype - - - PMID:21893601 - CMPO:0000274 - disorganised peripheral actin phenotype - A phenotype observation at the level of the cortical actin cytoskeleton where the component shows an irregular organization - disorganised cortical actin cytoskeleton - - - - - - - - - increased lamellipodia width phenotype - - - PMID:21893601 - increased width of lamellae - CMPO:0000276 - A phenotype observation at the level of a lamellipodia where the components width has increased. - increased lamellipodia width - - - - - - - - - decreased lamellipodia width phenotype - - - CMPO:0000277 - A phenotype observation at the level of a lamellipodia where the components width has decreased. - PMID:21893601 - decreased lamellipodia width - decreased width of lamellae - - - - - - - - - fan-shaped lamellipodia phenotype - - - CMPO:0000278 - A phenotype observation where the lamellipodia is shaped in the form of a fan. - PMID:21893601 - fan-shaped lamellipodia - motile lamellae - - - - - - - - - lamellipodium phenotype - - A phenotype observation at the level of a cell with an increased amount of lamellipodia. - CMPO:0000279 - lamellipodium phenotype - - - - - - - - - cell projection phenotype - - A phenotype observation at the level of a cellular component relating to a prolongation or process extending from a cell, e.g. a cilium, lamellipodium or axon. - CMPO:0000280 - cell projection phenotype - - - - - - - - - filopodium phenotype - - A phenotype observation at the level of the filopodium; a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast. - CMPO:0000281 - filopodium - - - - - - - - - layered cells in population - - PMID:21893601 - CMPO:0000282 - layered cells - Cells not stopping at confluence and growing on top of each other in layers - - - - - - - - - actin cytoskeleton phenotype - - CMPO:0000283 - A phenotype observation at the level of the actin cytoskeleton, the part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. - actin cytoskeleton - - - - - - - - - increased actin cytoskeleton mass phenotype - - CMPO:0000284 - A phenotype observation at the level of a actin cytoskeleton where the components mass has increased - PMID:21893601 - increased actin cytoskeleton mass - - - - - - - - - decreased actin cytoskeleton mass phenotype - - PMID:21893601 - CMPO:0000285 - A phenotype observation at the level of a actin cytoskeleton where the components mass has decreased. - decreased actin cytoskeleton mass - - - - - - - - - aggregated microtubules phenotype - - - PMID:21893601 - A phenotype observation where microtubules form clump-like structures as opposed to filaments - CMPO:0000286 - aggregated microtubules - microtubule clumps - - - - - - - - - microtubules nuclear bracket phenotype - - - PMID:21893601 - CMPO:0000287 - A phenotype observation where the microtubules form two crescent shaped brackets around the nucleus - microtubules nuclear bracket - - - - - - - - - microtubules nuclear ring phenotype - - - CMPO:0000288 - PMID:21893601 - microtubule nuclear ring - A phenotype observation where the microtubules form a ring around the nucleus - microtubules nuclear ring - - - - - - - - - increased amount of stress fibers phenotype - - A phenotype observation at the level of any stress fibers where the components number has increased. - CMPO:0000289 - increased amount of stress fibers - more actin stress fibers - pmid:21893601 - - - - - - - - - punctate actin foci phenotype - - - puncta actin filament phenotype - A phenotype observation where actin is observed as small patches or spots all over the cell - CMPO:0000290 - punctate actin foci - - - - - - - - - increased amount of punctate actin foci phenotype - - more actin puncta - CMPO:0000291 - PMID:21893601 - increased actin puncta - A phenotype observation where a cell has an increased amount of actin observed as small patches or spots all over the cell - increased amount of punctate actin foci - - - - - - - - - cell population layer phenotype - - http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20216 - A phenotype of a culture in which cells grow as a monolayer that is attached to the culture substrate. - CMPO:0000292 - cell layer phenotype - - - - - - - - - loss of cell monolayer - - loss of cell monolayer - Loss of sheet like monolayer leading to empty patches - CMPO:0000293 - lost cell monolayer - - - - - - - - - increased actin localised to the nucleus - - - CMPO:0000294 - increased nuclear actin - A phenotype observation where many actin filaments are observed in or around the nucleus - PMID: 21893601 - - - - - - - - - increased actin localised to the cytoplasm - - - PMID: 21893601 - CMPO:0000296 - increased cytoplasmic actin - A phenotype observation where many actin filaments are observed in the cytoplasm - - - - - - - - - increased amount of stress fibers located in the cell cortex phenotype - - Increased amount of actin stress fibers in the cortical area - more cortical actin stress fibers - A phenotype observation at the level of stress fibers localized to the cell cortex where the components number has increased. - CMPO:0000297 - increased amount of stress fibers located in the cell cortex - pmid:21893601 - - - - - - - - - increased amount of transverse stress fibers - - pmid:21893601 - CMPO:0000298 - Increased amount of actin stress fibers, forming transverse arcs located in the cell cortex - more transverse actin stress fibers - A phenotype observation at the level of stress fibers where the components number has increased and formed transverse arcs which are located in the cell cortex - - - - - - - - - increased amount of zig-zag stress fibers - - CMPO:0000299 - more zig-zag actin stress fibers - A phenotype observation at the level of stress fibers where the components number has increased and formed a zig zag pattern across the cell - Increased amount of actin stress fibers, with zig-zag pattern across the cell - pmid:21893601 - - - - - - - - - more multinucleate cells - - CMPO:0000300 - Increased cells that are multinucleated - - - - - - - - - no cells phenotype - - CMPO:0000301 - Absence of cells - PMID:21893601 - no cells - - - - - - - - - actin nuclear ring phenotype - - - nuclear actin ring - PMID:21893601 - A phenotype observation where the microtubules form a ring around the nucleus - CMPO:0000302 - actin nuclear ring - - - - - - - - - cell component morphology phenotype - - CMPO:0000303 - A phenotype observation at the level of a cellular component relating to the components shape, size or structure - cell component morphology - - - - - - - - - cell cycle arrested phenotype - - - - A phenotype of a cell where a particular process is arrested, or ends earlier in time than expected - CMPO:0000304 - cell cycle arrested - - - - - - - - - metaphase arrested phenotype - - - metaphase arrest - CMPO:0000305 - PMID:20360735 - A phenotype of a cell arrested in mitotic metaphase - metaphase arrested - - - - - - - - - delayed process phenotype - - - A phenotype of a cell where a particular process is delayed - CMPO:0000306 - delayed process - - - - - - - - - metaphase delayed phenotype - - - metaphase delay - PMID:20360735 - CMPO:0000307 - A phenotype of a cell where mitotic metaphase is delayed - metaphase delayed - - - - - - - - - impaired cell migration - - abnormal cell migration - CMPO:0000309 - A phenotype where the cell migration is impaired - - - - - - - - - increased duration of cell migration process phenotype - - PMID:20360735 - A phenotype where the cell migration process occurs for longer, typically observed as a cell moving a further distance - CMPO:0000312 - increased duration of cell migration process - - - - - - - - - decreased duration of cell migration process phenotype - - CMPO:0000313 - A phenotype where the cell migration process duration is reduced, typically observed as a cell moving a shorter distance - decreased duration of cell migration process - - - - - - - - - exit from mitosis phenotype - - CMPO:0000314 - A phenotype observation at the level of the exit from mitosis - exit from mitosis - - - - - - - - - absence of cell process phenotype - - - cell physiology phenotype - A phenotype observation at the level of a cellular process where the cell process is absent - CMPO:0000315 - absence of cell process - - - - - - - - - abnormal cell growth phenotype - - CMPO:0000316 - A phenotype observation of the process in which the cell growth is abnormal - abnormal cell growth - - - - - - - - - cell growth arrested phenotype - - - CMPO:0000317 - A phenotype observation of the process in which the cell growth is arrested - cell growth arrested - - - - - - - - - mild decrease in rate of protein secretion - - PMID:22660414 - A phenotype observation where the rate of release of proteins from a cell is mildly decreased - CMPO:0000318 - mild inhibition of protein secretion - - - - - - - - - strong decrease in rate of protein secretion - - strong inhibition of protein secretion - PMID:22660414 - CMPO:0000319 - A phenotype observation where the rate of release of proteins from a cell is severly decreased - - - - - - - - - increased cell spreading phenotype - - CMPO:0000320 - A phenotype observation where there is an increased occurance of cell spreading - increased cell spreading - - - - - - - - - mild increase of cell spreading phenotype - - A phenotype observation where there is a mild increase of cell spreading - PMID:19667130 - CMPO:0000321 - moderate cell spreading - mild increase of cell spreading - - - - - - - - - strong increase of cell spreading phenotype - - A phenotype observation where there is a severe increase in cell spreading - CMPO:0000322 - extensive cell spreading - strong increase of cell spreading - - - - - - - - - decreased cell spreading phenotype - - poor cell spreading - A phenotype observation where there is a decreased occurance of cell spreading - CMPO:0000323 - PMID:19667130 - decreased cell spreading - - - - - - - - - absence of cell spreading phenotype - - - A phenotype observation where cell spreading is absent - absence of cell spreading - no spreading cells - CMPO:0000324 - - - - - - - - - spread cell morphology phenotype - - CMPO:0000325 - A phenotype observation where a cell shows a thin and large projected areas, with developed matrix adhesions at the cell periphery, as opposed to round cells with no or few adhesion sites - spread cell morphology - spreading cell shape - - - - - - - - - abnormal chromosome segregation phenotype - - chromatin bridges - PMID:20360735 - A phenotype observation of the process in which the chromosome segregation is abnormal - multiple DNA masses - segregation problems - CMPO:0000326 - abnormal chromosome segregation - lagging chromosomes - - - - - - - - - mitotic prophase phenotype - - - A phenotype observation at the level of the mitotic prophase of the cell cycle - CMPO:0000327 - mitotic prophase phenotype - - - - - - - - - increased duration of mitotic prophase phenotype - - A phenotype observation where the duration of the mitotic prophase of the cell cycle is increased - CMPO:0000328 - increased duration of mitotic prophase - - - - - - - - - decreased duration of mitotic prophase phenotype - - CMPO:0000329 - A phenotype observation where the duration of the mitotic prophase of the cell cycle is decreased - decreased duration of mitotic prophase - - - - - - - - - decreased frequency of negative regulation of NF-kappaB transcription factor activity phenotype - - A phenotype observation where the frequency of a process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB is decreased. - decreased number of oscillations; the amplitude of the first peak is comparable to control, although the duration may be increased; the time of the second and third peaks is delayed, due to greater interval times between termination and initiation of nuclear translocation responses - CMPO:0000330 - decreased NF-kB oscillation - PMID:23300644 - decreased frequency of negative regulation of NF-kappaB transcription factor activity - - - - - - - - - increased frequency of negative regulation of NF-kappaB transcription factor activity phenotype - - A phenotype observation where the frequency of a process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB is increased. - CMPO:0000331 - PMID:23300644 - increased NF-kB oscillation - increased frequency of negative regulation of NF-kappaB transcription factor activity - increased number of oscillations; the amplitude of the second and third peak is increased and nuclear translocation responses occur at increased intervals. - - - - - - - - - cytoplasmic sequestering of NF-kappaB phenotype - - - - PMID:23300644 - increased number of oscillations; the amplitude of the second and third peak is increased and nuclear translocation responses occur at increased intervals. - no NF-kB oscillation phenotype - A phenotype observation where the frequency of a process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB is increased. - CMPO:0000332 - cytoplasmic sequestering of NF-kappaB - - - - - - - - - abnormal release of cytoplasmic sequestered NF-kappaB phenotype - - - A phenotype observation where the release of NF-kappaB from specific molecules in the cytoplasm to which it was bound, thereby allowing its translocation into the nucleus, is abnormal. - contains all cases that are significantly different from the rest, but don't share any clear commonalities. NF-kB oscillation patterns are not synchronized within a cell population, oscillation amplitude and frequency follow erratic patterns - different NF-kB oscillation phenotype - PMID:23300644 - CMPO:0000333 - abnormal release of cytoplasmic sequestered NF-kappaB - - - - - - - - - regulation of process phenotype - - CMPO:0000334 - A phenotype observation where any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. - regulation of process phenotype - - - - - - - - - bright nuclear body phenotype - - A phenotype obervation where the nuclear body's color brightness is relatively high. - pmid:22884692 - bright nuclear body - increased intensity of nuclear body - CMPO:0000335 - - - - - - - - - round focal adhesion - - CMPO:0000337 - A phenotype observation where the shape of the focal adhesion has every part of the surface or the circumference equidistant from the center. - - - - - - - - - mitosis arrested - - - CMPO:0000338 - A phenotype of a cell that is arrested at mitosis - PMID:20360735 - mitotic arrest - - - - - - - - - increased cell size in population - - - increased cell size in population - large cells - CMPO:0000340 - A population of cells where there is an increased number of large cells in the population - - - - - - - - - pyknotic nuclear phenotype - - CMPO:0000341 - A phenotype observation at the level of the nucleus underoging Pyknosis, or karyopyknosis, consisting of the irreversible condensation of chromatin in the nucleus of a cell undergoing necrosis or apoptosis. - pyknotic nucleus - pyknotic cell - - - - - - - - - prometaphase arrested phenotype - - - prometaphase arrest - CMPO:0000343 - A phenotype of a cell arrested in mitotic prometaphase - prometaphase arrested - - - - - - - - - prometaphase delayed phenotype - - - - A phenotype of a cell where mitotic prometaphase is delayed - CMPO:0000344 - prometaphase delay - prometaphase delayed - - - - - - - - - increased variability of nuclear shape in population - - CMPO:0000345 - A population of cells where the nuclei exhibit a high variability of shape - variable cell shape - - - - - - - - - decreased rate of intracellular protein transport phenotype - - A phenotype observation where the rate of intracellular protein transport is decreased - CMPO:0000346 - pmid:21795383 - decreased rate of intracellular protein transport - - - - - - - - - absence of mitotic metaphase process phenotype - - - A phenotype resulting in the absence of mitotic metaphase process - CMPO:0000347 - absence of mitotic metaphase - - - - - - - - - mitotic metaphase plate congression phenotype - - - metaphase alignment problem - CMPO:0000348 - A phenotype observation at the level of the cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis. - mitotic metaphase plate congression - - - - - - - - - increased substrate-dependent cell migration, cell extension phenotype - - CMPO:0000349 - A phenotype where an increased formation of a cell surface protrusion, such as a lamellipodium or filopodium, at the leading edge of a migrating cell is observed. - increased protrusive activity - increased substrate-dependent cell migration, cell extension - - - - - - - - - increased substrate-dependent cell migration phenotype - - CMPO:0000350 - increased directional cell migration - A phenotype where an increased occurrence of the orderly movement of a cell from one site to another along a substrate such as the extracellular matrix is observed. - increased substrate-dependent cell migration - - - - - - - - - increased microtubule-based processes phenotype - - A phenotype where an increased occurance of any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins, is observed. - increased microtubule-based processes - microtubule processes - CMPO:0000351 - - - - - - - - - increased monopolar cell elongation phenotype - - - CMPO:0000353 - A phenotype observation of the process in which a cell increases in size due to polarized growth from one end of a cell. - increased monopolar cell elongation - increased polar cell elongation - - - - - - - - - decreased monopolar cell elongation phenotype - - - decreased polar cell elongation - CMPO:0000354 - A phenotype observation of the process in which a cell decreases in size due to polarized growth from one end of a cell. - decreased monopolar cell elongation - - - - - - - - - mild actin-mediated cell contraction phenotype - - A phenotype of a cell contraction caused by an actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in mild contraction of all or part of the cell body. - CMPO:0000355 - mild actin-mediated cell contraction - - - - - - - - - cell component localization phenotype - - cell component localization - A phenotype where any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location is observed - CMPO:0000356 - cell component localisation - - - - - - - - - polylobed nuclear phenotype - - CMPO:0000357 - acinus nuclear phenotype - A phenotype observation where the shape of the nucleus resembles a many-lobed berry, such as a raspberry. - - - - - - - - - increased rate of DNA amplification - - A phenotype of a cell where the rate of DNA amplification is increased - CMPO:0000358 - increased rate of DNA amplification - - - - - - - - - increased amount of DNA - - - CMPO:0000359 - A phenotype observation where a cell has an increased amount of DNA - increased amount of DNA - - - - - - - - - centriole replication phenotype - - CMPO:0000360 - A phenotype of a cell in which the biological process resulting in a doubling of the number of centrioles in the cell is affected - pmid:18620859 - centriole duplication phenotype - centriole replication - - - - - - - - - increased centriole replication phenotype - - - centriole amplification phenotype - CMPO:0000361 - A phenotype of a cell in which the biological process resulting in a the number of centrioles is increased - increased centriole replication - - - - - - - - - decreased centriole replication phenotype - - CMPO:0000362 - A phenotype of a cell in which the biological process resulting in a the number of centrioles is decreased - centriole underduplication phenotype - decreased centriole replication - - - - - - - - - protein localization to cellular component phenotype - - CMPO:0000363 - - - - - - - - - s-shaped cell phenotype - - - A phenotype observation at the level of the cell shape where the cell is in a shape that consists of two curves in opposite directions. - kinky cell - S-shaped cell - FYPO:0002760 - CMPO:0000364 - z-shaped cell - sigmoid cell - PMID: 25373780 - kinked cell - - - - - - - - - stubby cell phenotype - - - CMPO:0000367 - wide cell - FYPO:0002106 - A phenotype observation at the level of the cell shape where the shape is stubby. The cell diameter is larger than normal and the cell length is shorter than normal. - PMID: 25373780 - Stubby cell - - - - - - - - - microtubule cytoskeleton morphology phenotype - - - CMPO:0000368 - A phenotype observation at the level of the microtubule cytoskeleton relating to the components shape, size or structure - microtubule cytoskeleton morphology - - - - - - - - - microtubule cytoskeleton morphology during mitotic interphase - - - CMPO:0000368 - A physical cellular phenotype in interphase of the mitotic cell cycle where the the size, shape, or structure of the microtubule cytoskeleton is observed. - FYPO:0003625 - PMID: 25373780 - microtubule cytoskeleton morphology during mitotic interphase - - - - - - - - - elongated cytoplasmic microtubules phenotype - - - A physical cellular phenotype which cells form cytoplasmic microtubules that are longer than normal. - long cytoplasmic microtubules - elongated cytoplasmic microtubules - PMID: 25373780 - CMPO:0000370 - elongated cytoplasmic microtubules - FYPO:0000233 - - - - - - - - - shortened cytoplasmic microtubules phenotype - - - CMPO:0000371 - FYPO:0002401 - shortened cytoplasmic microtubules - PMID: 25373780 - elongated cytoplasmic microtubules - A physical cellular phenotype which cells form cytoplasmic microtubules that are shorter than normal. - - - - - - - - - increased number of microtubule bundle phenotype - - extra microtubule bundles - PMID: 25373780 - increased microtubule bundling - A phenotype observation at the level of microtubule bundle where the components number has increased. - increased number of microtubule bundle - more microtubule bundles - FYPO:0003595 - increased level of MT bundles - CMPO:0000372 - - - - - - - - - microtubule morphology phenotype - - - A phenotype observation at the level of the microtubule relating to the components shape, size or structure - PMID: 25373780 - CMPO:0000373 - microtubule morphology - - - - - - - - - microtubule morphology during interphase phenotype - - - PMID: 25373780 - CMPO:0000374 - A phenotype observation at the level of the microtubule relating to the components shape, size or structure observed in mitotic interphase. - microtubule morphology during interphase - - - - - - - - - more cells with interphase microtubule phenotype - - PMID: 25373780 - An increased number of interphase microtubule phenotype in population. - more cells with interphase microtubule - CMPO:0000375 - - - - - - - - - microtubule spindle morphology phenotype - - CMPO:0000376 - A phenotype observation at the level of the microtubule spindle relating to the components shape, size or structure - PMID: 25373780 - microtubule spindle morphology - - - - - - - - - microtubule spindle morphology during metaphase phenotype - - - CMPO:0000377 - A phenotype observation at the level of the microtubule spindle relating to the components shape, size or structure observed during metaphase. - PMID: 25373780 - microtubule spindle morphology during metaphase - - - - - - - - - more cells with metaphase microtubule spindles phenotype - - more cells with metaphase microtubule spindles - CMPO:0000378 - PMID: 25373780 - SP increased - An increased number of metaphase microtubule spindles in population. - - - - - - - - - linear microtubule morphology phenotype - - A phenotype observation at the level of the microtubule where the microtuble are narrow, with the two opposite margins parallel. - CMPO:0000379 - PMID: 25373780 - linear microtubule morphology - - - - - - - - - cell component organisation phenotype - - - CMPO:0000380 - A phenotype obesrvation relating to the orgnaistation of cellular componets in the cell. - cell component organisation - - - - - - - - - microtubule organisation phenotype - - CMPO:0000380 - A phenotype observation relating to the organisation of cellular components in the cell. - cell component organisation - - - - - - - - - microtubule array phenotype - - A phenotype observation relating to the organisation of microtubules in the cell, where the microtubules are organized into an array. - CMPO:0000382 - microtubule array - PMID: 25373780 - - - - - - - - - more cells with interphase microtubule arrays phenotype - - - An increased number of interphase microtubule array phenotype in population. - more cells with interphase microtubule arrays - PMID: 25373780 - CMPO:0000383 - IP increased - - - - - - - - - interphase phenotype - - A phenotype observation at the level of interphase of the cell cycle - CMPO:0000384 - interphase phenotype - - - - - - - - - mitotic interphase phenotype - - - A phenotype observation at the level of interphase of the cell cycle - CMPO:0000384 - mitotic interphase phenotype - - - - - - - - - anaphase phenotype - - A phenotype observation at the level of anaphase of the cell cycle - CMPO:0000386 - anaphase phenotype - - - - - - - - - fewer cells with metaphase microtubule spindles phenotype - - CMPO:0000387 - fewer cells with metaphase microtubule spindles - SP reduced - PMID: 25373780 - A decreased number of metaphase microtubule spindles in population. - - - - - - - - - fewer cells with interphase microtubule arrays phenotype - - - PMID: 25373780 - IP reduced - CMPO:0000388 - A decreased number of interphase microtubule array phenotypes in population. - fewer cells with interphase microtubule arrays - - - - - - - - - protein localized in golgi phenotype - - A phenotype observation in which a protein is observed to be localized within the Golgi apparatus. - PMID: 23509072 - protein localised in Golgi - protein localised in Golgi apparatus - protein localized to Golgi - protein localized to Golgi apparatus - CMPO:0000390 - - - - PMID: 23509072 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in Golgi - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localized to Golgi apparatus - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in Golgi apparatus - - - - - A phenotype observation in which a protein is observed to be localized within the Golgi apparatus. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localized to Golgi - - - - - - - - - - protein localized in bud neck phenotype - - A phenotype observation in which a protein is observed to be localized within a cellular bud neck. - PMID: 23509072 - protein localised in bud neck - protein localized in cellular bud neck - protein localized to bud neck - CMPO:0000391 - - - - A phenotype observation in which a protein is observed to be localized within a cellular bud neck. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in bud neck - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localized in cellular bud neck - - - - - PMID: 23509072 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localized to bud neck - - - - - - - - - - protein localized in cell periphery phenotype - - A phenotype observation in which a protein is observed to be localized within the cell periphery. - PMID: 23509072 - protein localised in cell periphery - protein localized to cell periphery - CMPO:0000392 - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in cell periphery - - - - - A phenotype observation in which a protein is observed to be localized within the cell periphery. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localized to cell periphery - - - - - PMID: 23509072 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - protein localized in cytosol phenotype - - A phenotype observation in which a protein is observed to be localized within the cytosol. - PMID: 23509072 - protein localised in cytosol - protein localized to cytosol - CMPO:0000393 - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in cytosol - - - - - A phenotype observation in which a protein is observed to be localized within the cytosol. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localized to cytosol - - - - - PMID: 23509072 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - protein localized in endoplasmic reticulum phenotype - - A phenotype observation in which a protein is observed to be localized within the endoplasmic reticulum. - PMID: 23509072 - protein localised in endoplasmic reticulum - protein localized to endoplasmic reticulum - CMPO:0000394 - - - - PMID: 23509072 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localized to endoplasmic reticulum - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in endoplasmic reticulum - - - - - A phenotype observation in which a protein is observed to be localized within the endoplasmic reticulum. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - protein localized in mitochondrion phenotype - - A phenotype observation in which a protein is observed to be localized within a mitochondrion. - PMID: 23509072 - protein localised in mitochondria - protein localised in mitochondrion - protein localized to mitochonria - protein localized to mitochonrion - CMPO:0000395 - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in mitochondria - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localized to mitochonrion - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localized to mitochonria - - - - - A phenotype observation in which a protein is observed to be localized within a mitochondrion. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in mitochondrion - - - - - PMID: 23509072 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - protein localized in nuclear periphery phenotype - - A phenotype observation in which a protein is observed to be localized within the nuclear periphery. - PMID: 23509072 - protein localised in nuclear periphery - protein localized to nuclear periphery - CMPO:0000396 - - - - A phenotype observation in which a protein is observed to be localized within the nuclear periphery. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in nuclear periphery - - - - - PMID: 23509072 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localized to nuclear periphery - - - - - - - - - - protein localized in nucleolus phenotype - - A phenotype observation in which a protein is observed to be localized within the nucleolus. - PMID: 23509072 - protein localised in nucleolus - protein localized to nucleolus - CMPO:0000397 - - - - PMID: 23509072 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - A phenotype observation in which a protein is observed to be localized within the nucleolus. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in nucleolus - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localized to nucleolus - - - - - - - - - - protein localized in nucleus phenotype - - A phenotype observation in which a protein is observed to be localized within the nucleus. - PMID: 23509072 - protein localised in nucleus - protein localized to nucleus - CMPO:0000398 - - - - PMID: 23509072 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - A phenotype observation in which a protein is observed to be localized within the nucleus. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in nucleus - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localized to nucleus - - - - - - - - - - protein localized in peroxisome phenotype - - A phenotype observation in which a protein is observed to be localized within a peroxisome. - PMID: 23509072 - protein localised in peroxisome - protein localized to peroxisome - CMPO:0000399 - - - - PMID: 23509072 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - A phenotype observation in which a protein is observed to be localized within a peroxisome. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in peroxisome - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localized to peroxisome - - - - - - - - - - protein localized in punctate foci phenotype - - A phenotype observation in which a protein is observed to be localized within punctate foci - PMID: 23509072 - protein localised in punctate foci - protein localized to punctate foci - CMPO:0000400 - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in punctate foci - - - - - A phenotype observation in which a protein is observed to be localized within punctate foci - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - PMID: 23509072 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localized to punctate foci - - - - - - - - - - protein localized in vacuole phenotype - - A phenotype observation in which a protein is observed to be localized within a vacuole. - PMID: 23509072 - protein localised in vacuole - protein localized to vacuole - CMPO:0000401 - - - - A phenotype observation in which a protein is observed to be localized within a vacuole. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in vacuole - - - - - PMID: 23509072 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localized to vacuole - - - - - - - - - - protein localized in vacuolar membrane phenotype - - - A phenotype observation in which a protein is observed to be localized within a vacuolar membrane. - PMID: 23509072 - protein localised in vacuolar membrane - protein localized to vacuolar membrane - CMPO:0000402 - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in vacuolar membrane - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localized to vacuolar membrane - - - - - A phenotype observation in which a protein is observed to be localized within a vacuolar membrane. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - PMID: 23509072 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - protein localized to nuclear body - - A phenotype observation in which a protein is observed to be localized within the nuclear body. - protein localised in nuclear body - protein localized to nuclear body - CMPO:0000403 - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in nuclear body - - - - - A phenotype observation in which a protein is observed to be localized within the nuclear body. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localized to nuclear body - - - - - - - - - - protein localized in Cajal body phenotype - - A phenotype observation in which a protein is observed to be localized within a Cajal body. - PubMed ID:24127217 - protein localised in Cajal body phenotype - CMPO:0000404 - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in Cajal body phenotype - - - - - PubMed ID:24127217 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - A phenotype observation in which a protein is observed to be localized within a Cajal body. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - protein localized in nuclear speckle phenotype - - A phenotype observation in which a protein is observed to be localized within a nuclear speckle. - PubMed ID:24127217 - protein localised in nuclear speckle phenotype - CMPO:0000405 - - - - A phenotype observation in which a protein is observed to be localized within a nuclear speckle. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - PubMed ID:24127217 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in nuclear speckle phenotype - - - - - - - - - - protein localized in paraspeckle phenotype - - A phenotype observation in which a protein is observed to be localized within a paraspeckle. - PubMed ID:24127217 - protein localised in paraspeckle phenotype - CMPO:0000406 - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in paraspeckle phenotype - - - - - PubMed ID:24127217 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - A phenotype observation in which a protein is observed to be localized within a paraspeckle. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - protein localized in PML body phenotype - - A phenotype observation in which a protein is observed to be localized within a PML body. - PubMed ID:24127217 - protein localised in PML body phenotype - protein localised in Promyelocytic Leukemia nuclear body phenotype - protein localized in Promyelocytic Leukemia nuclear body phenotype - CMPO:0000407 - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localized in Promyelocytic Leukemia nuclear body phenotype - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in Promyelocytic Leukemia nuclear body phenotype - - - - - PubMed ID:24127217 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in PML body phenotype - - - - - A phenotype observation in which a protein is observed to be localized within a PML body. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - protein localized in polycomb body phenotype - - A phenotype observation in which a protein is observed to be localized within a polycomb body. - PubMed ID:24127217 - protein localised in PcG body phenotype - protein localized in PcG body phenotype - protein localized in polycomb body phenotype - CMPO:0000408 - - - - PubMed ID:24127217 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localized in PcG body phenotype - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in PcG body phenotype - - - - - A phenotype observation in which a protein is observed to be localized within a polycomb body. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localized in polycomb body phenotype - - - - - - - - - - fewer cells with G1 phase microtubule arrays phenotype - - - A decreased number of post-anaphase or G1 phase microtubule arrays in population phenotype - PAA decreased - PMID: 25373780 - fewer cells with post-anaphase microtubule arrays - CMPO:0000410 - - - - A decreased number of post-anaphase or G1 phase microtubule arrays in population phenotype - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - fewer cells with post-anaphase microtubule arrays - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - PAA decreased - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - PMID: 25373780 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - fewer cells with S phase microtubule arrays phenotype - - - A decreased number of post-mitotic interphase or S phase microtubule arrays in population phenotype - IP2 decreased - PMID: 25373780 - fewer cells with post-mitotic interphase microtubule arrays - CMPO:0000411 - - - - PMID: 25373780 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - A decreased number of post-mitotic interphase or S phase microtubule arrays in population phenotype - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - IP2 decreased - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - fewer cells with post-mitotic interphase microtubule arrays - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - more cells with G1 phase microtubule arrays phenotype - - - An increased number of post-anaphase or G1 phase microtubule arrays in population phenotype - PAA increased - PMID: 25373780 - more cells with post-anaphase microtubule arrays - CMPO:0000412 - - - - PAA increased - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - more cells with post-anaphase microtubule arrays - - - - - PMID: 25373780 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - An increased number of post-anaphase or G1 phase microtubule arrays in population phenotype - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - more cells with S phase microtubule arrays phenotype - - - An increased number of post-mitotic interphase or S phase microtubule arrays in population phenotype - IP2 increased - PMID: 25373780 - more cells with post-mitotic interphase microtubule arrays - CMPO:0000413 - - - - PMID: 25373780 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - more cells with post-mitotic interphase microtubule arrays - - - - - IP2 increased - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - An increased number of post-mitotic interphase or S phase microtubule arrays in population phenotype - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - cell response to stress phenotype - - A phenotype observation of respone to stress process within a cell. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). - CMPO:0000414 - cell response to stress - - - - - - - - - cell response to DNA damage phenotype - - DNA damage - A phenotype observation of a process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. - CMPO:0000415 - cell response to DNA damage - - - - - - - - - fewer aggregated cells in population phenotype - - CMPO:0000416 - fewer aggregated cells in population - PMID:24446484 - defective cell-cell aggregation - The population has a decreased number of cells forming cell-cell aggregates. - - - - - - - - - lack of protein in cell component localization phenotype - - A phenotype observation in which a protein is absent or decreased from the expected localisation of protein localisation process - PMID: 23547032 - protein absent from localisation to cellular component - example 'the smt3allR mutant does not show localization at the bud neck' - CMPO:0000417 - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein absent from localisation to cellular component - - - - - PMID: 23547032 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - A phenotype observation in which a protein is absent or decreased from the expected localisation of protein localisation process - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - response to stimulus phenotype - - A phenotype observation at the level of a response to stimulus process - CMPO:0000419 - - - - - - - - - response to chemical phenotype - - CMPO:0000420 - A phenotype observation at the level of a response to stimulus process - - - - - - - - - cellular response to chemical stimulus phenotype - - CMPO:0000421 - A phenotype observation at the level of a response to stimulus process - - - - - - - - - telophase phenotype - - CMPO:0000422 - A phenotype observation at the level of telophase of the cell cycle - telophase phenotype - - - - - - - - - mitotic telophase phenotype - - - A phenotype observation at the level of mitotic telophase of the cell cycle - CMPO:0000423 - telophase phenotype - - - - - - - - - telophase arrested phenotype - - - CMPO:0000424 - A phenotype of a cell where the mitotic telophase process is arrested, or ends earlier in time than expected - telophase arrested - - - - - - - - - protein localized in centrosome phenotype - - A phenotype observation in which a protein is observed to be localized within a centrosome. - PMID:23086237 - protein localisation in centrosome - protein localised in centrosome - protein localised to centrosome - protein localization in centrosome - CMPO:0000425 - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised to centrosome - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localization in centrosome - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localisation in centrosome - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in centrosome - - - - - A phenotype observation in which a protein is observed to be localized within a centrosome. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - PMID:23086237 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - protein localized in nuclear pore phenotype - - - A phenotype observation in which a protein is observed to be localized within a nuclear pore. - PMID:23845946 - protein localisation in nuclear pore - protein localised in nuclear pore - protein localised to nuclear pore - protein localization in nuclear pore - CMPO:0000426 - - - - PMID:23845946 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised to nuclear pore - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localisation in nuclear pore - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in nuclear pore - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localization in nuclear pore - - - - - A phenotype observation in which a protein is observed to be localized within a nuclear pore. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - kinetochore phenotype - - CMPO:0000427 - A collection of qualities that inhere in any constituent part of the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. - kinetochore phenotype - - - - - - - - - fan-shaped cell phenotype - - - A phenotype observation at the level of the cell shape where the cell is fan-shaped - CMPO:0000428 - fan-shaped cell - - - - - - - - - cell polypeptide phenotype - - cell protein phenotype - CMPO:0000429 - A phenotype observation at the level of the cell protein - cell protein phenotype - - - - - - - - - altered level of substance in cell - - A cell phenotype in which the amount of a specific substance measured in a cell differs from normal. - CMPO:0000430 - FYPO:0000989 - PomBase:mah - altered level of substance in cell - - - - - - - - - altered level of polypetide in cell - - - A cell phenotype in which the amount of polypetide measured in a cell differs from normal. - CMPO:0000431 - altered level of polypeptide in cell - - - - - - - - - altered level of polypetide in cell nucleus - - - CMPO:0000432 - A cell phenotype in which the amount of polypetide measured in a cell nucleus differs from normal. - altered level of protein in cell nucleus - altered level of substance in cell nucleus - - - - - - - - - increased level of polypetide in cell nucleus - - A cell phenotype in which the amount of polypetide measured in a cell nucleus increases from normal. - increased level of protein in cell nucleus - CMPO:0000433 - incressed level of polypetide in cell nucleus - - - - - - - - - decreased level of polypetide in cell nucleus - - decreased level of protein in cell nucleus - CMPO:0000434 - A cell phenotype in which the amount of polypetide measured in a cell nucleus descreases from normal. - descreased level of polypetide in cell nucleus - - - - - - - - - negative regulation of protein import into nucleus phenotype - - CMPO:0000435 - A phenotype observation where any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus. - regulation of process phenotype - - - - - - - - - positive regulation of protein import into nucleus phenotype - - A phenotype observation where any process that starts or increases the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus. - CMPO:0000436 - positive regulation of protein import into nucleus - - - - - - - - - abnormal mitotic cell cycle phase phenotype - - - CMPO:0000437 - A phenotype where the mitotic cell cycle phase is abnormal - abnormal mitotic cell cycle phase - - - - - - - - - abnormal microtubule cytoskeleton morphology during mitotic interphase - - CMPO:0000438 - FYPO:0003625 - PMID: 25373780 - A physical cellular phenotype in interphase of the mitotic cell cycle where the the size, shape, or structure of the microtubule cytoskeleton is abnormal. - abnormal microtubule cytoskeleton morphology during mitotic interphase - - - - - - - - - absence of protein localized in bud neck phenotype - - - A phenotype observation in which a protein is not localized within a cellular bud neck. - CMPO:0000439 - - - - A phenotype observation in which a protein is not localized within a cellular bud neck. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - protein localized in actin filament phenotype - - A phenotype observation in which a protein is observed to be localized within an actin filament. - PubMed: 22361696 - protein localised in actin filament phenotype - CMPO:0000440 - - - - PubMed: 22361696 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - A phenotype observation in which a protein is observed to be localized within an actin filament. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in actin filament phenotype - - - - - - - - - - protein localized in intermediate filament phenotype - - A phenotype observation in which a protein is observed to be localized within an intermediate filament. - PubMed: 22361696 - protein localised in intermediate filament phenotype - CMPO:0000441 - - - - PubMed: 22361696 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - A phenotype observation in which a protein is observed to be localized within an intermediate filament. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in intermediate filament phenotype - - - - - - - - - - protein localized in microtubule phenotype - - A phenotype observation in which a protein is observed to be localized within a microtubule. - PubMed: 22361696 - protein localised in microtubule phenotype - CMPO:0000442 - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in microtubule phenotype - - - - - A phenotype observation in which a protein is observed to be localized within a microtubule. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - PubMed: 22361696 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - protein localized in nuclear membrane phenotype - - A phenotype observation in which a protein is observed to be localized the nuclear membrane. - PubMed: 22361696 - protein localised in nuclear membrane phenotype - protein localised in nuclear envelope phenotype - CMPO:0000443 - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in nuclear membrane phenotype - - - - - PubMed: 22361696 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - A phenotype observation in which a protein is observed to be localized the nuclear membrane. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - protein localized in nucleoli fibrillar center phenotype - - A phenotype observation in which a protein is observed to be localized within the nucleolar fibrillar center. - PubMed: 22361696 - protein localised in nucleoli fibrillar center phenotype - CMPO:0000444 - - - - PubMed: 22361696 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in nucleoli fibrillar center phenotype - - - - - A phenotype observation in which a protein is observed to be localized within the nucleolar fibrillar center. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - protein localized in nucleoplasm phenotype - - A phenotype observation in which a protein is observed to be localized within the nucloplasm. - PubMed: 22361696 - protein localised in nucleoplasm phenotype - CMPO:0000445 - - - - PubMed: 22361696 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in nucleoplasm phenotype - - - - - A phenotype observation in which a protein is observed to be localized within the nucloplasm. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - protein localized in plasma membrane phenotype - - - A phenotype observation in which a protein is observed to be localized within the plasma membrane. - PubMed: 22361696 - protein localised in plasma membrane phenotype - CMPO:0000446 - - - - PubMed: 22361696 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - A phenotype observation in which a protein is observed to be localized within the plasma membrane. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in plasma membrane phenotype - - - - - - - - - - protein localized in vesicle phenotype - - A phenotype observation in which a protein is observed to be localized within a vesicle. - PubMed: 22361696 - protein localised in vesicle phenotype - CMPO:0000447 - - - - PubMed: 22361696 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - A phenotype observation in which a protein is observed to be localized within a vesicle. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in vesicle phenotype - - - - - - - - - - cell killing phenotype - - CMPO:0000448 - A phenotype where the the cells are killing either its own cells or those of another organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions. - cell killing phenotype - - - - - - - - - T cell mediated killing against a tumor cell phenotype - - - A phenotype where the the cells are killing either its own cells or those of another organism. The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. - CMPO:0000449 - 'T cell mediated cytotoxicity directed against tumor cell target phenotype - T cell mediated killing against a tumor cell phenotype - - - - - - - - - more aggregated cells in population phenotype - - The population has an increased number of cells forming cell-cell aggregates. - CMPO:0000450 - more aggregated cells in population phenotype - - - - - - - - - increased nucelar area phenotype - - CMPO:0000451 - A phenotype observation where the area of the nucelus has increased. - increased nucelar area phenotype - - - - - - - - - decreased nucelar area phenotype - - A phenotype observation where the area of the nucelus has decreased. - CMPO:0000452 - decreased nucelar area phenotype - - - - - - - - - decreased cell size in population - - - small cells - CMPO:0000453 - A population of cells where there is an increased number of small cells in the population - decreased cell size in population - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - 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- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - 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- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - diff --git a/release/cmpo.obo b/release/cmpo.obo deleted file mode 100644 index fea6896e..00000000 --- a/release/cmpo.obo +++ /dev/null @@ -1,3770 +0,0 @@ -format-version: 1.2 -subsetdef: cmpo "CMPO subset" -subsetdef: goantislim_grouping "Grouping classes that can be excluded" -subsetdef: gocheck_do_not_annotate "Term not to be used for direct annotation" -subsetdef: gocheck_do_not_manually_annotate "Term not to be used for direct manual annotation" -subsetdef: goslim_aspergillus "Aspergillus GO slim" -subsetdef: goslim_candida "Candida GO slim" -subsetdef: goslim_chembl "ChEMBL protein targets summary" -subsetdef: goslim_generic "Generic GO slim" -subsetdef: goslim_goa "GOA and proteome slim" -subsetdef: goslim_metagenomics "Metagenomics GO slim" -subsetdef: goslim_pir "PIR GO slim" -subsetdef: goslim_plant "Plant GO slim" -subsetdef: goslim_pombe "Fission yeast GO slim" -subsetdef: goslim_synapse "synapse GO slim" -subsetdef: goslim_virus "Viral GO slim" -subsetdef: goslim_yeast "Yeast GO slim" -subsetdef: gosubset_prok "Prokaryotic GO subset" -subsetdef: mf_needs_review "Catalytic activity terms in need of attention" -subsetdef: termgenie_unvetted "Terms created by TermGenie that do not follow a template and require additional vetting by editors" -subsetdef: virus_checked "Viral overhaul terms" -synonymtypedef: systematic_synonym "Systematic synonym" EXACT -ontology: http://www.ebi.ac.uk/cmpo/cmpo.owl/subsets/cmpo -owl-axioms: Prefix(owl:=)\nPrefix(rdf:=)\nPrefix(xml:=)\nPrefix(xsd:=)\nPrefix(rdfs:=)\n\n\nOntology(\nEquivalentClasses( ObjectSomeValuesFrom( ObjectIntersectionOf(ObjectSomeValuesFrom( ) )))\nEquivalentClasses( ObjectSomeValuesFrom( ObjectIntersectionOf( )))\nEquivalentClasses( ObjectSomeValuesFrom( ObjectIntersectionOf( )))\nAnnotationAssertion( \"CMPO:0000368\")\nAnnotationAssertion( \"part_of\"^^xsd:string)\nAnnotationAssertion( \"CMPO:0000380\")\nAnnotationAssertion( \"CMPO:0000384\")\nAnnotationAssertion( \"towards\"^^xsd:string)\n) - -[Term] -id: CMPO:0000002 -name: cell population phenotype -def: "A quality that that inheres in a population of cells" [] -subset: cmpo -is_a: CMPO:0000003 ! cellular phenotype -property_value: prefLabel "cell population phenotype" xsd:string - -[Term] -id: CMPO:0000003 -name: cellular phenotype -def: "A quality that inheres in or specifically depends on a cellular process, a cell population, a whole cell or a subcellular structure." [] -subset: cmpo -property_value: prefLabel "cellular phenotype" xsd:string - -[Term] -id: CMPO:0000005 -name: cell morphology phenotype -def: "A collection of qualities that inhere in the whole cell relating to the cell's shape, size or structure" [] -subset: cmpo -is_a: CMPO:0000258 ! single cell phenotype -is_a: CMPO:0000303 ! cell component morphology phenotype -property_value: prefLabel "cell morphology" xsd:string - -[Term] -id: CMPO:0000007 -name: cell process phenotype -def: "A quality that inheres in a cellular process" [] -subset: cmpo -synonym: "cell physiology phenotype" EXACT [] -is_a: CMPO:0000003 ! cellular phenotype -property_value: prefLabel "cell process phenotype" xsd:string - -[Term] -id: CMPO:0000008 -name: cell component number phenotype -def: "An increase or decrease in the number of specified components within a cell" [] -subset: cmpo -is_a: CMPO:0000258 ! single cell phenotype -property_value: prefLabel "cell component number" xsd:string - -[Term] -id: CMPO:0000010 -name: cell component size phenotype -def: "A collection of size qualities that inhere in a cellular component" [] -subset: cmpo -is_a: CMPO:0000303 ! cell component morphology phenotype -property_value: prefLabel "cell component size" xsd:string - -[Term] -id: CMPO:0000011 -name: cell component shape phenotype -def: "A collection of shape qualities that inhere in a cellular component" [] -subset: cmpo -is_a: CMPO:0000303 ! cell component morphology phenotype -property_value: prefLabel "cell component shape" xsd:string - -[Term] -id: CMPO:0000012 -name: cell component structure phenotype -def: "A collection of structure qualities that inhere in a cellular component" [] -subset: cmpo -is_a: CMPO:0000303 ! cell component morphology phenotype -property_value: prefLabel "cell component structure" xsd:string - -[Term] -id: CMPO:0000013 -name: cell viability phenotype -def: "A phenotype relating to the ability of a cell survive or to develop normally" [] -subset: cmpo -is_a: CMPO:0000258 ! single cell phenotype -property_value: prefLabel "cell viability" xsd:string - -[Term] -id: CMPO:0000014 -name: viable cell phenotype -def: "A cell phenotype where the cell is viable" [] -subset: cmpo -is_a: CMPO:0000013 ! cell viability phenotype -property_value: prefLabel "viable cell" xsd:string - -[Term] -id: CMPO:0000015 -name: inviable cell phenotype -def: "A cell phenotype where the cell is not viable" [] -subset: cmpo -is_a: CMPO:0000013 ! cell viability phenotype -property_value: prefLabel "inviable cell" xsd:string - -[Term] -id: CMPO:0000016 -name: cell nucleation phenotype -def: "A nucleation quality that inheres in the whole cell" [] -subset: cmpo -is_a: CMPO:0000258 ! single cell phenotype -property_value: prefLabel "cell nucleation" xsd:string - -[Term] -id: CMPO:0000017 -name: mononuclear cell phenotype -subset: cmpo -is_a: CMPO:0000016 ! cell nucleation phenotype -property_value: prefLabel "mononuclear cell" xsd:string - -[Term] -id: CMPO:0000018 -name: multinucleated cell phenotype -def: "A multinucleate quality that inheres in a cell" [] -subset: cmpo -synonym: "polynuclear cell" EXACT [] -is_a: CMPO:0000016 ! cell nucleation phenotype -property_value: prefLabel "multinucleated cell" xsd:string - -[Term] -id: CMPO:0000020 -name: cytoskeletal phenotype -def: "A collection of qualities that inhere in any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice." [] -subset: cmpo -is_a: CMPO:0000150 ! organelle phenotype -property_value: prefLabel "cytoskeletal phenotype" xsd:string - -[Term] -id: CMPO:0000021 -name: endoplasmic reticulum phenotype -def: "A collection of qualities that inhere in any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae." [] -subset: cmpo -is_a: CMPO:0000150 ! organelle phenotype -property_value: prefLabel "endoplasmic reticulum phenotype" xsd:string - -[Term] -id: CMPO:0000022 -name: golgi phenotype -def: "A collection of qualities that inhere in any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack" [] -subset: cmpo -is_a: CMPO:0000150 ! organelle phenotype -property_value: prefLabel "golgi phenotype" xsd:string - -[Term] -id: CMPO:0000023 -name: mitochondrion phenotype -def: "A collection of qualities that inhere in any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells." [] -subset: cmpo -synonym: "mitochondrial part phenotype" EXACT [] -is_a: CMPO:0000150 ! organelle phenotype -property_value: prefLabel "mitochondrion phenotype" xsd:string - -[Term] -id: CMPO:0000024 -name: nuclear phenotype -def: "A collection of qualities that inhere in any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated." [] -subset: cmpo -is_a: CMPO:0000150 ! organelle phenotype -property_value: prefLabel "nuclear phenotype" xsd:string - -[Term] -id: CMPO:0000026 -name: organelle shape phenotype -def: "A collection of qualities that inhere in a cellular organelle relating to the organelle's shape" [] -subset: cmpo -is_a: CMPO:0000011 ! cell component shape phenotype -property_value: prefLabel "organelle shape" xsd:string - -[Term] -id: CMPO:0000027 -name: nucleus shape phenotype -def: "A collection of qualities that inhere in the nucleus relating to the ratios of distances between its features (points, edges, surfaces and also holes etc)." [] -subset: cmpo -synonym: "nuclear shape" EXACT [] -is_a: CMPO:0000026 ! organelle shape phenotype -is_a: CMPO:0000249 ! nuclear morphology phenotype - -[Term] -id: CMPO:0000028 -name: cell adhesion phenotype -def: "A phenotype where the attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules is observed" [] -subset: cmpo -is_a: CMPO:0000007 ! cell process phenotype -property_value: prefLabel "cell adhesion phenotype" xsd:string - -[Term] -id: CMPO:0000029 -name: cell cycle phenotype -def: "A collection of qualities that inhere the cell cycle" [] -subset: cmpo -is_a: CMPO:0000007 ! cell process phenotype -property_value: prefLabel "cell cycle phenotype" xsd:string - -[Term] -id: CMPO:0000030 -name: cell death phenotype -def: "A phenotype where the cell death process process is observed" [] -subset: cmpo -is_a: CMPO:0000007 ! cell process phenotype -property_value: IAO:0000119 PMID:20360735 xsd:string -property_value: prefLabel "cell death phenotype" xsd:string - -[Term] -id: CMPO:0000032 -name: cell membrane organisation phenotype -def: "A phenotype observation of a process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [] -subset: cmpo -is_a: CMPO:0000007 ! cell process phenotype -property_value: prefLabel "cell membrane organisation phenotype" xsd:string - -[Term] -id: CMPO:0000033 -name: cell migration phenotype -def: "A phenotype of a cell involving its translation from one location to another" [] -subset: cmpo -is_a: CMPO:0000244 ! cell component movement phenotype -property_value: IAO:0000119 PMID:20360735 xsd:string -property_value: prefLabel "cell migration phenotype" xsd:string - -[Term] -id: CMPO:0000035 -name: cell growth phenotype -def: "A phenotype observation of the process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [] -subset: cmpo -is_a: CMPO:0000007 ! cell process phenotype -property_value: prefLabel "cell growth phenotype" xsd:string - -[Term] -id: CMPO:0000036 -name: chromosome segregation phenotype -def: "A phenotype observation of the process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the alignment of chromosomes at the metaphase plate, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [] -subset: cmpo -is_a: CMPO:0000007 ! cell process phenotype -property_value: prefLabel "chromosome segregation phenotype" xsd:string - -[Term] -id: CMPO:0000037 -name: metabolic process phenotype -def: "A phenotype observation of chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [] -subset: cmpo -is_a: CMPO:0000007 ! cell process phenotype -property_value: prefLabel "metabolic process phenotype" xsd:string - -[Term] -id: CMPO:0000038 -name: organelle localization phenotype -def: "A phenotype observations where any process in which an organelle is transported to, and/or maintained in, a specific location." [] -subset: cmpo -is_a: CMPO:0000356 ! cell component localization phenotype -property_value: prefLabel "organelle localization phenotype" xsd:string - -[Term] -id: CMPO:0000039 -name: regulation of metabolic process phenotype -def: "A phenotype observation where a process modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [] -subset: cmpo -is_a: CMPO:0000334 ! regulation of process phenotype -property_value: prefLabel "regulation of metabolic process phenotype" xsd:string - -[Term] -id: CMPO:0000040 -name: regulation of signal transduction phenotype -def: "A phenotype observation of a process that modulates the frequency, rate or extent of signal transduction." [] -subset: cmpo -is_a: CMPO:0000334 ! regulation of process phenotype -property_value: prefLabel "regulation of signal transduction phenotype" xsd:string - -[Term] -id: CMPO:0000041 -name: transport phenotype -def: "A phenotype observation of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [] -subset: cmpo -is_a: CMPO:0000356 ! cell component localization phenotype -property_value: prefLabel "transport phenotype" xsd:string - -[Term] -id: CMPO:0000042 -name: increased cell component number phenotype -def: "An increased number of specified cellular components relative to normal" [] -subset: cmpo -is_a: CMPO:0000008 ! cell component number phenotype -property_value: prefLabel "increased cell component number" xsd:string - -[Term] -id: CMPO:0000043 -name: decreased cell component number phenotype -def: "A decrease in number of specified cellular components relative to normal" [] -subset: cmpo -is_a: CMPO:0000008 ! cell component number phenotype -property_value: prefLabel "decreased cell component number" xsd:string - -[Term] -id: CMPO:0000047 -name: apoptotic DNA fragmentation phenotype -def: "A phenotype observation where the cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments." [] -subset: cmpo -synonym: "apoptotic DNA" BROAD [] -is_a: CMPO:0000037 ! metabolic process phenotype -property_value: prefLabel "apoptotic DNA fragmentation" xsd:string - -[Term] -id: CMPO:0000048 -name: apoptotic cell shape phenotype -def: "A phenotype observation at the level of the cell shape where the cell is apoptotic" [] -comment: dispersed outline with blobby protrusions -subset: cmpo -is_a: CMPO:0000005 ! cell morphology phenotype -is_a: CMPO:0000012 ! cell component structure phenotype -property_value: prefLabel "apoptotic cell shape" xsd:string - -[Term] -id: CMPO:0000049 -name: aggregated cells in population -def: "Groups of cells gathered or tending to gather into a mass or whole." [] -subset: cmpo -synonym: "aggregated cells" EXACT [] -synonym: "cell aggregates" EXACT [] -synonym: "cell islands" EXACT [] -synonym: "clustered cells" EXACT [] -is_a: CMPO:0000002 ! cell population phenotype -property_value: prefLabel "aggregated cells in population" xsd:string - -[Term] -id: CMPO:0000050 -name: altered cell number in population -def: "Number of cells in a population phenotype" [] -subset: cmpo -is_a: CMPO:0000002 ! cell population phenotype -property_value: prefLabel "cell number in population" xsd:string - -[Term] -id: CMPO:0000051 -name: increased cell numbers -def: "The population has an increased number of cells with respect to normal" [] -subset: cmpo -is_a: CMPO:0000050 ! altered cell number in population -property_value: prefLabel "increased cell numbers" xsd:string - -[Term] -id: CMPO:0000052 -name: decreased cell numbers -def: "The population has a decreased number of cells with respect to normal" [] -subset: cmpo -synonym: "decreased cells" EXACT [] -synonym: "fewer cells" EXACT [] -synonym: "less cells" EXACT [] -synonym: "reduced cell numbers" EXACT [] -is_a: CMPO:0000050 ! altered cell number in population -property_value: prefLabel "decreased cell numbers" xsd:string - -[Term] -id: CMPO:0000053 -name: more cells in S -def: "increased number of cells in S phase mitosis" [] -subset: cmpo -is_a: CMPO:0000051 ! increased cell numbers - -[Term] -id: CMPO:0000054 -name: cell population phenotype by process -def: "A population of cells where a specifcied biological process is occuring or is observed. " [] -subset: cmpo -is_a: CMPO:0000002 ! cell population phenotype -property_value: prefLabel "cell population process" xsd:string - -[Term] -id: CMPO:0000055 -name: more cells in G1 -def: "increased cell numbers in G1" [] -subset: cmpo -is_a: CMPO:0000051 ! increased cell numbers - -[Term] -id: CMPO:0000056 -name: more cells in G2M -def: "increased number of cells in G2M" [] -subset: cmpo -synonym: "increased mitotic index" EXACT [] -is_a: CMPO:0000051 ! increased cell numbers - -[Term] -id: CMPO:0000057 -name: fewer cells in G1 -def: "decreased number of cells in G1 phase" [] -subset: cmpo -synonym: "less cells in G1" EXACT [] -is_a: CMPO:0000052 ! decreased cell numbers - -[Term] -id: CMPO:0000058 -name: fewer cells in G2M -def: "decreased number of cells in G2M phase" [] -subset: cmpo -synonym: "decreased mitotic index" EXACT [] -synonym: "less cells in G2M" EXACT [] -is_a: CMPO:0000052 ! decreased cell numbers - -[Term] -id: CMPO:0000059 -name: fewer cells in S -def: "decreased number of cells in S phase" [] -subset: cmpo -synonym: "decreased number of cells in S" EXACT [] -synonym: "less cells in S" EXACT [] -is_a: CMPO:0000052 ! decreased cell numbers - -[Term] -id: CMPO:0000063 -name: decreased number of focal adhesion phenotype -def: "A phenotype observation at the level of focal adhesions where the components number has decreased. " [] -subset: cmpo -synonym: "decreased focal adhesion abundance" EXACT [] -is_a: CMPO:0000043 ! decreased cell component number phenotype -property_value: prefLabel "decreased number of focal adhesion" xsd:string - -[Term] -id: CMPO:0000064 -name: centrally located focal adhesion phenotype -def: "A phenotype observation where the focal adhesion is located in a position equidistant from the edges of the cell" [] -subset: cmpo -is_a: CMPO:0000065 ! cell component position phenotype -property_value: IAO:0000119 PMID:19667130 xsd:string -property_value: prefLabel "centrally located focal adhesion" xsd:string - -[Term] -id: CMPO:0000065 -name: cell component position phenotype -def: "A phenotype observation at the level of a cellular component relating to the components position in the cell" [] -subset: cmpo -is_a: CMPO:0000259 ! cellular component phenotype -property_value: prefLabel "cell component position" xsd:string - -[Term] -id: CMPO:0000066 -name: peripheral focal adhesion phenotype -def: "A phenotype observation where the focal adhesions's position is at the edge or boundary of a related entity." [] -subset: cmpo -is_a: CMPO:0000065 ! cell component position phenotype -property_value: IAO:0000119 PMID:19667130 xsd:string -property_value: prefLabel "peripheral focal adhesion" xsd:string - -[Term] -id: CMPO:0000067 -name: decreased number of filopodia phenotype -def: "A phenotype observation at the level of filopodia where the components number has decreased. " [] -subset: cmpo -synonym: "fewer filopodia" EXACT [] -is_a: CMPO:0000074 ! decreased number of cell projections phenotype -property_value: prefLabel "decreased number of filopodia" xsd:string - -[Term] -id: CMPO:0000068 -name: decreased number of microtubules phenotype -def: "A phenotype observation at the level of microtubules where the components number has decreased. " [] -subset: cmpo -synonym: "fewer microtubules" EXACT [] -is_a: CMPO:0000043 ! decreased cell component number phenotype -property_value: prefLabel "decreased number of microtubules" xsd:string - -[Term] -id: CMPO:0000069 -name: decreased number of dendritic branches phenotyope -def: "A phenotype observation at the level of dendritic branches where the components number has decreased. " [] -subset: cmpo -is_a: CMPO:0000043 ! decreased cell component number phenotype - -[Term] -id: CMPO:0000071 -name: cell with projections -def: "Single cell with protrusions" [] -subset: cmpo -synonym: "cell with protrusions" EXACT [] -is_a: CMPO:0000005 ! cell morphology phenotype -property_value: IAO:0000119 PMID:20531400 xsd:string - -[Term] -id: CMPO:0000072 -name: increased number of cell projections phenotype -def: "An increase in number of any cell projection relative to normal" [] -subset: cmpo -is_a: CMPO:0000042 ! increased cell component number phenotype -property_value: prefLabel "increased number of cell projections" xsd:string - -[Term] -id: CMPO:0000073 -name: more cells with projections -def: "increased number of cells in population with projections" [] -subset: cmpo -is_a: CMPO:0000051 ! increased cell numbers - -[Term] -id: CMPO:0000074 -name: decreased number of cell projections phenotype -def: "A phenotype observation at the level of cell projections where the components number has decreased. " [] -subset: cmpo -is_a: CMPO:0000043 ! decreased cell component number phenotype -property_value: prefLabel "decreased number of cell projections" xsd:string - -[Term] -id: CMPO:0000075 -name: fewer cells with projections -def: "decreased number of cells in population with projections" [] -subset: cmpo -is_a: CMPO:0000052 ! decreased cell numbers - -[Term] -id: CMPO:0000076 -name: increased number of filopodia -def: "A phenotype observation at the level of filopodia where the components number has increased. " [] -subset: cmpo -synonym: "more filopodia" EXACT [] -is_a: CMPO:0000072 ! increased number of cell projections phenotype - -[Term] -id: CMPO:0000077 -name: elongated cell phenotype -def: "A phenotype observation at the level of the cell shape where the cell is elongated, with a length notably greater than its width" [] -subset: cmpo -synonym: "bipolar cell" BROAD [] -is_a: CMPO:0000005 ! cell morphology phenotype -is_a: CMPO:0000011 ! cell component shape phenotype -property_value: prefLabel "elongated cell" xsd:string - -[Term] -id: CMPO:0000078 -name: elongated cells in population -def: "Cells in population with a length notably greater than their width" [] -subset: cmpo -is_a: CMPO:0000051 ! increased cell numbers -is_a: CMPO:0000163 ! cell population phenotype by morphology -property_value: IAO:0000119 "PMID:21893601; PMID:20531400" xsd:string -property_value: prefLabel "elongated cells in population" xsd:string - -[Term] -id: CMPO:0000080 -name: increased number of lamellipodia phenotype -def: "A phenotype observation at the level of lamellipodia where the components number has increased. " [] -subset: cmpo -synonym: "lamellipodium phenotype" EXACT [] -is_a: CMPO:0000072 ! increased number of cell projections phenotype -property_value: prefLabel "increased number of lamellipodia" xsd:string - -[Term] -id: CMPO:0000081 -name: decreased number of lamellipodia phenotype -def: "A phenotype observation at the level of lamellipodia where the components number has decreased. " [] -subset: cmpo -is_a: CMPO:0000074 ! decreased number of cell projections phenotype -property_value: prefLabel "decreased number of lamellipodia" xsd:string - -[Term] -id: CMPO:0000083 -name: more lamellipodia cells -def: "increased lamellipodia cells in population phenotype" [] -subset: cmpo -is_a: CMPO:0000073 ! more cells with projections - -[Term] -id: CMPO:0000084 -name: fewer lamellipodia cells -def: "decreased lamellipodia cells in population phenotype" [] -subset: cmpo -is_a: CMPO:0000075 ! fewer cells with projections - -[Term] -id: CMPO:0000085 -name: cell ploidy phenotype -def: "A phenotype observation at the level of the whole cell relating to the cell's ploidy" [] -subset: cmpo -is_a: CMPO:0000258 ! single cell phenotype -property_value: prefLabel "cell ploidy" xsd:string - -[Term] -id: CMPO:0000086 -name: polyploid cell phenotype -def: "A cell phenotype with more than two homologous sets of chromosomes." [] -subset: cmpo -is_a: CMPO:0000085 ! cell ploidy phenotype -property_value: prefLabel "polyploid cell" xsd:string - -[Term] -id: CMPO:0000087 -name: S phase mitotic phenotype -def: "A phenotype observation at the level of athe S phase of the mitotic cell cycle" [] -subset: cmpo -is_a: CMPO:0000090 ! cell cycle phase phenotype -is_a: CMPO:0000194 ! mitotic process phenotype -property_value: prefLabel "S phase mitotic phenotype" xsd:string - -[Term] -id: CMPO:0000088 -name: G1 phase mitotic phenotype -def: "A phenotype observation at the level of a G1 phase of the mitotic cell cycle" [] -subset: cmpo -is_a: CMPO:0000090 ! cell cycle phase phenotype -is_a: CMPO:0000194 ! mitotic process phenotype -property_value: prefLabel "G1 phase mitotic phenotype" xsd:string - -[Term] -id: CMPO:0000089 -name: G2/M transition phenotype -def: "A phenotype observation at the level of the G2/M transition of the mitotic cell cycle" [] -subset: cmpo -is_a: CMPO:0000194 ! mitotic process phenotype -property_value: prefLabel "G2/M transition phenotype" xsd:string - -[Term] -id: CMPO:0000090 -name: cell cycle phase phenotype -def: "A phenotype observation at the level of a cell cycle phase" [] -subset: cmpo -is_a: CMPO:0000007 ! cell process phenotype -property_value: prefLabel "cell cycle phase phenotype" xsd:string - -[Term] -id: CMPO:0000091 -name: more polyploid cells -def: "increased number of polyploid cells in population" [] -subset: cmpo -is_a: CMPO:0000051 ! increased cell numbers - -[Term] -id: CMPO:0000092 -name: increased number of focal adhesion phenotype -def: "A phenotype observation at the level of focal adhesions where the components number has increased. " [] -subset: cmpo -synonym: "increased focal adhesion abundance" EXACT [] -is_a: CMPO:0000042 ! increased cell component number phenotype -property_value: prefLabel "increased number of focal adhesion" xsd:string - -[Term] -id: CMPO:0000093 -name: increased number of nucleoli phenotype -def: "A phenotype observation at the level of nucleoli where the components number has increased. " [] -subset: cmpo -is_a: CMPO:0000042 ! increased cell component number phenotype -property_value: prefLabel "increased number of nucleoli" xsd:string - -[Term] -id: CMPO:0000094 -name: decreased number of nucleoli phenotype -def: "A phenotype observation at the level of nucleoli where the components number has decreased. " [] -subset: cmpo -is_a: CMPO:0000043 ! decreased cell component number phenotype -property_value: prefLabel "decreased number of nucleoli" xsd:string - -[Term] -id: CMPO:0000095 -name: more cells with decreased number of nucleoli -def: "more cells with decreased number of nucleoli" [] -subset: cmpo -is_a: CMPO:0000051 ! increased cell numbers - -[Term] -id: CMPO:0000096 -name: more cells with increased number of nucleoli -def: "increased number of nucleoli in population phenotype" [] -subset: cmpo -is_a: CMPO:0000051 ! increased cell numbers - -[Term] -id: CMPO:0000097 -name: increased number of microtubules phenotype -def: "A phenotype observation at the level of microtubules where the components number has increased. " [] -subset: cmpo -synonym: "more microtubules" EXACT [] -is_a: CMPO:0000042 ! increased cell component number phenotype -property_value: prefLabel "increased number of microtubules" xsd:string - -[Term] -id: CMPO:0000102 -name: phagosomes phenotype -def: "A phenotype observation at the level of the phagosomes, a membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis." [] -subset: cmpo -synonym: "phagosomes present phenotype" EXACT [] -is_a: CMPO:0000259 ! cellular component phenotype -property_value: prefLabel "phagosomes" xsd:string - -[Term] -id: CMPO:0000103 -name: phagosomes absent phenotype -def: "A phenotype observation where phagosomes are absent" [] -subset: cmpo -is_a: CMPO:0000102 ! phagosomes phenotype -is_a: CMPO:0000159 ! absence of cellular component phenotype -property_value: prefLabel "phagosomes absent" xsd:string - -[Term] -id: CMPO:0000104 -name: actin filament phenotype -def: "A phenotype observation at the level of the actin filaments, a filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells." [] -subset: cmpo -is_a: CMPO:0000020 ! cytoskeletal phenotype -property_value: prefLabel "actin filament phenotype" xsd:string - -[Term] -id: CMPO:0000105 -name: increased number of actin filament phenotype -def: "A phenotype observation at the level of actin filaments where the components number has increased. " [] -subset: cmpo -synonym: "actin fiber cells" EXACT [] -synonym: "more actin" EXACT [] -synonym: "more total actin" EXACT [] -is_a: CMPO:0000042 ! increased cell component number phenotype -is_a: CMPO:0000104 ! actin filament phenotype -property_value: IAO:0000119 "PMID: 21893601" xsd:string -property_value: IAO:0000119 PMID:20531400 xsd:string -property_value: prefLabel "increased number of actin filament" xsd:string - -[Term] -id: CMPO:0000106 -name: decreased number of actin filament phenotype -def: "A phenotype observation at the level of actin filaments where the components number has decreased. " [] -subset: cmpo -synonym: "less actin" EXACT [] -synonym: "less total actin" EXACT [] -is_a: CMPO:0000043 ! decreased cell component number phenotype -is_a: CMPO:0000104 ! actin filament phenotype -property_value: IAO:0000119 "PMID: 21893601" xsd:string -property_value: prefLabel "decreased number of actin filament" xsd:string - -[Term] -id: CMPO:0000107 -name: more actin filament cells -def: "increased number of actin filament cells in population" [] -subset: cmpo -is_a: CMPO:0000051 ! increased cell numbers - -[Term] -id: CMPO:0000108 -name: fewer actin filament cells -def: "decreased number of actin filament phenotypes in population" [] -subset: cmpo -synonym: "decreased number of actin filament cells" EXACT [] -is_a: CMPO:0000052 ! decreased cell numbers - -[Term] -id: CMPO:0000109 -name: centered cytoskeleton phenotype -def: "A phenotype observation where the cytoskeleton is located in a position equidistant from the edges of the cell" [] -subset: cmpo -is_a: CMPO:0000020 ! cytoskeletal phenotype -is_a: CMPO:0000065 ! cell component position phenotype -property_value: prefLabel "centered cytoskeleton" xsd:string - -[Term] -id: CMPO:0000110 -name: centered nucleus phenotype -def: "A phenotype observation where the nucleus is located in a position equidistant from the edges of the cell" [] -subset: cmpo -is_a: CMPO:0000024 ! nuclear phenotype -is_a: CMPO:0000065 ! cell component position phenotype -property_value: prefLabel "centered nucleus" xsd:string - -[Term] -id: CMPO:0000111 -name: dispersed nucleus phenotype -def: "A phenotype observation where the nucleus is distributed or spread over a considerable extent." [] -subset: cmpo -is_a: CMPO:0000024 ! nuclear phenotype -is_a: CMPO:0000065 ! cell component position phenotype -property_value: prefLabel "dispersed nucleus" xsd:string - -[Term] -id: CMPO:0000112 -name: apoptopic nucleus phenotype -def: "A phenotype observation at the level of nucleus consisting of blebbing of the nucleus and DNA fragmentation due to the cell undergoing a specific form of programmed cell death termed apoptosis." [] -subset: cmpo -is_a: CMPO:0000012 ! cell component structure phenotype -is_a: CMPO:0000249 ! nuclear morphology phenotype -property_value: prefLabel "apoptopic nucleus" xsd:string - -[Term] -id: CMPO:0000113 -name: deformed nucleus -def: "A phenotype observation where the nucleus is distorted in form" [] -subset: cmpo -is_a: CMPO:0000249 ! nuclear morphology phenotype - -[Term] -id: CMPO:0000114 -name: peripheral nucleus phenotype -def: "A phenotype observation where the nucleus's position is at the edge or boundary of a related entity." [] -subset: cmpo -is_a: CMPO:0000024 ! nuclear phenotype -is_a: CMPO:0000065 ! cell component position phenotype -property_value: prefLabel "peripheral nucleus" xsd:string - -[Term] -id: CMPO:0000115 -name: peripheral cytoskeleton phenotype -def: "A phenotype observation where the cytoskeleton's position is at the edge or boundary of a related entity." [] -subset: cmpo -is_a: CMPO:0000020 ! cytoskeletal phenotype -is_a: CMPO:0000065 ! cell component position phenotype -property_value: prefLabel "peripheral cytoskeleton" xsd:string - -[Term] -id: CMPO:0000116 -name: abnormal cell shape phenotype -def: "A phenotype observation at the level of the cell shape where the shape is abnormal" [] -subset: cmpo -is_a: CMPO:0000005 ! cell morphology phenotype -is_a: CMPO:0000011 ! cell component shape phenotype -property_value: prefLabel "abnormal cell shape" xsd:string - -[Term] -id: CMPO:0000117 -name: bilobed nucleus phenotype -def: "A lobed quality inhering in a nucleus by virtue of the nucleus being divided into or having two lobes." [] -subset: cmpo -synonym: "bilobed" BROAD [] -is_a: CMPO:0000027 ! nucleus shape phenotype -property_value: prefLabel "bilobed nucleus" xsd:string - -[Term] -id: CMPO:0000118 -name: round cell phenotype -def: "A phenotype observation at the level of the cell shape where the cell is round" [] -comment: not spreading cell -subset: cmpo -synonym: "circular cell" EXACT [] -synonym: "low eccentricity cell" EXACT [] -synonym: "spherical cell" EXACT [] -is_a: CMPO:0000005 ! cell morphology phenotype -is_a: CMPO:0000011 ! cell component shape phenotype -property_value: IAO:0000119 PMID:21893601 xsd:string -property_value: prefLabel "round cell" xsd:string - -[Term] -id: CMPO:0000119 -name: elongated focal adhesion -def: "A phenotype observation of the length of the focal adhesion is notably higher than the width." [] -subset: cmpo -synonym: "long focal adhesion" BROAD [] -is_a: CMPO:0000011 ! cell component shape phenotype - -[Term] -id: CMPO:0000120 -name: elongated nucleus -def: "A phenotype observation of the length of the nucleus is notably higher than the width." [] -subset: cmpo -synonym: "long nucleus" BROAD [] -is_a: CMPO:0000027 ! nucleus shape phenotype - -[Term] -id: CMPO:0000121 -name: arrow shaped cell phenotype -def: "A phenotype observation at the level of the cell shape where the cell is arrow shaped, with a wide front and a sharp tail, displaying monopolar cell growth" [] -subset: cmpo -synonym: "triangular shaped cell" EXACT [] -is_a: CMPO:0000005 ! cell morphology phenotype -is_a: CMPO:0000011 ! cell component shape phenotype - -[Term] -id: CMPO:0000122 -name: triangular shaped cell phenotype -def: "A phenotype observation at the level of the cell shape where the cell has a triangular shape, with a wide front and a sharp tail, displaying cell motility" [] -subset: cmpo -synonym: "arrow shaped cell" BROAD [] -is_a: CMPO:0000005 ! cell morphology phenotype -is_a: CMPO:0000011 ! cell component shape phenotype -property_value: prefLabel "triangular shaped cell" xsd:string - -[Term] -id: CMPO:0000123 -name: round nucleus phenotype -def: "A phenotype observation where the shape of the nucleus has every part of the surface or the circumference equidistant from the center." [] -subset: cmpo -synonym: "circular nucleus" EXACT [] -synonym: "round nucleus" EXACT [] -is_a: CMPO:0000027 ! nucleus shape phenotype -property_value: prefLabel "round nucleus" xsd:string - -[Term] -id: CMPO:0000125 -name: nuclear body phenotype -def: "A phenotype observation at the level of the nuclear body, an extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [] -subset: cmpo -is_a: CMPO:0000024 ! nuclear phenotype -property_value: prefLabel "nuclear body" xsd:string - -[Term] -id: CMPO:0000126 -name: increased nuclear body size phenotype -def: "A phenotype observation where the nuclear body size is relatively high." [] -subset: cmpo -is_a: CMPO:0000125 ! nuclear body phenotype -is_a: CMPO:0000186 ! increased cell component size phenotype -is_a: CMPO:0000249 ! nuclear morphology phenotype -property_value: IAO:0000119 PMID:22884692 xsd:string -property_value: prefLabel "increased nuclear body size" xsd:string - -[Term] -id: CMPO:0000127 -name: decreased nuclear body size phenotype -def: "A phenotype observation where the nuclear body size is relatively low." [] -subset: cmpo -is_a: CMPO:0000125 ! nuclear body phenotype -is_a: CMPO:0000187 ! decreased cell component size phenotype -is_a: CMPO:0000249 ! nuclear morphology phenotype -property_value: IAO:0000119 PMID:22884692 xsd:string -property_value: prefLabel "decreased nuclear body size" xsd:string - -[Term] -id: CMPO:0000128 -name: increased cell size phenotype -def: "A phenotype observation at the level of the cell size where a cell is larger with respect to normal/wild-type" [] -subset: cmpo -synonym: "big cell" EXACT [] -synonym: "increased cell area" EXACT [] -synonym: "large cell" EXACT [] -is_a: CMPO:0000005 ! cell morphology phenotype -is_a: CMPO:0000186 ! increased cell component size phenotype -property_value: IAO:0000119 PMID:20531400 xsd:string -property_value: prefLabel "increased cell size" xsd:string - -[Term] -id: CMPO:0000129 -name: decreased cell size phenotype -def: "A phenotype observation at the level of the cell size where a cell is smaller with respect to normal/wild-type" [] -subset: cmpo -synonym: "small cell" EXACT [] -is_a: CMPO:0000005 ! cell morphology phenotype -is_a: CMPO:0000187 ! decreased cell component size phenotype - -[Term] -id: CMPO:0000130 -name: decreased golgi volume phenotype -def: "A phenotype observation at the level of the golgi where the golgi's volume has decreased. " [] -subset: cmpo -is_a: CMPO:0000187 ! decreased cell component size phenotype -property_value: prefLabel "decreased golgi volume" xsd:string - -[Term] -id: CMPO:0000131 -name: increased golgi volume phenotype -def: "A phenotype observation at the level of the golgi where the golgi's volume has increased. " [] -subset: cmpo -is_a: CMPO:0000186 ! increased cell component size phenotype -property_value: prefLabel "increased golgi volume" xsd:string - -[Term] -id: CMPO:0000132 -name: decreased cilium length phenotype -def: "A phenotype observation at the level of a cilium where the components length has decreased. " [] -subset: cmpo -is_a: CMPO:0000187 ! decreased cell component size phenotype -is_a: CMPO:0000252 ! cilium morphology phenotype -property_value: prefLabel "decreased cilium length" xsd:string - -[Term] -id: CMPO:0000133 -name: increased cilium length phenotype -def: "A phenotype observation at the level of a cilium where the components length has increased. " [] -subset: cmpo -is_a: CMPO:0000186 ! increased cell component size phenotype -is_a: CMPO:0000252 ! cilium morphology phenotype -property_value: prefLabel "increased cilium length" xsd:string - -[Term] -id: CMPO:0000134 -name: decreased size of focal adhesion phenotype -def: "A phenotype observation where the size of the focal adhesion has decreased. " [] -subset: cmpo -is_a: CMPO:0000187 ! decreased cell component size phenotype -property_value: prefLabel "decreased size of focal adhesion" xsd:string - -[Term] -id: CMPO:0000135 -name: increased size of focal adhesion phenotype -def: "A phenotype observation where the size of the focal adhesion has increased. " [] -subset: cmpo -is_a: CMPO:0000186 ! increased cell component size phenotype -property_value: prefLabel "increased size of focal adhesion" xsd:string - -[Term] -id: CMPO:0000136 -name: decreased focal adhesion area phenotype -def: "A phenotype observation where the area of the focal adhesion has decreased. " [] -subset: cmpo -synonym: "small focal adhesion" EXACT [] -is_a: CMPO:0000134 ! decreased size of focal adhesion phenotype -property_value: IAO:0000119 pmid:19667130 xsd:string -property_value: prefLabel "decreased focal adhesion area" xsd:string - -[Term] -id: CMPO:0000137 -name: increased focal adhesion area phenotype -def: "A phenotype observation where the area of the focal adhesion has increased. " [] -subset: cmpo -synonym: "large focal adhesion" EXACT [] -is_a: CMPO:0000135 ! increased size of focal adhesion phenotype -property_value: IAO:0000119 pmid:19667130 xsd:string -property_value: prefLabel "increased focal adhesion area" xsd:string - -[Term] -id: CMPO:0000138 -name: decreased focal adhesion length phenotype -def: "A phenotype observation where the length of the focal adhesion has decreased. " [] -subset: cmpo -synonym: "short focal adhesion" EXACT [] -is_a: CMPO:0000134 ! decreased size of focal adhesion phenotype -property_value: IAO:0000119 pmid:19667130 xsd:string -property_value: prefLabel "decreased focal adhesion length" xsd:string - -[Term] -id: CMPO:0000139 -name: increased focal adhesion length phenotype -def: "A phenotype observation where the length of the focal adhesion has increased. " [] -subset: cmpo -is_a: CMPO:0000135 ! increased size of focal adhesion phenotype -property_value: prefLabel "increased focal adhesion length" xsd:string - -[Term] -id: CMPO:0000140 -name: increased nucleus size phenotype -def: "A phenotype observation where the size of the nucleus has increased" [] -subset: cmpo -synonym: "increased DNA area" BROAD [] -synonym: "large nuclei" EXACT [] -synonym: "large nucleus" EXACT [] -is_a: CMPO:0000186 ! increased cell component size phenotype -is_a: CMPO:0000249 ! nuclear morphology phenotype -property_value: IAO:0000119 PMID:20360735 xsd:string -property_value: IAO:0000119 PMID:20531400 xsd:string -property_value: prefLabel "increased nucleus size" xsd:string - -[Term] -id: CMPO:0000141 -name: decreased nucleus size phenotype -def: "A phenotype observation where the size of the nucleus has decreased" [] -subset: cmpo -synonym: "decreased DNA area" BROAD [] -synonym: "small nucleus" EXACT [] -is_a: CMPO:0000187 ! decreased cell component size phenotype -is_a: CMPO:0000249 ! nuclear morphology phenotype -property_value: IAO:0000119 PMID:20360735 xsd:string -property_value: IAO:0000119 PMID:21893601 xsd:string -property_value: prefLabel "decreased nucleus size" xsd:string - -[Term] -id: CMPO:0000143 -name: increased nuclei size in G1 phenotype -def: "A phenotype of a cell that has both an increased nuclei size phenotypes and a G1 phase phenotype" [] -subset: cmpo -is_a: CMPO:0000140 ! increased nucleus size phenotype -relationship: BFO:0000051 CMPO:0000140 ! has_part increased nucleus size phenotype -property_value: prefLabel "increased nuclei size in G1" xsd:string - -[Term] -id: CMPO:0000144 -name: decreased nuclei size in G1 phenotype -def: "A phenotype of a cell that has both a decreased nuclei size phenotypes and a G1 phase phenotype" [] -subset: cmpo -synonym: "small nuclei in G1" EXACT [] -is_a: CMPO:0000088 ! G1 phase mitotic phenotype -is_a: CMPO:0000141 ! decreased nucleus size phenotype -relationship: BFO:0000051 CMPO:0000088 ! has_part G1 phase mitotic phenotype -relationship: BFO:0000051 CMPO:0000141 ! has_part decreased nucleus size phenotype -property_value: prefLabel "decreased nuclei size in G1" xsd:string - -[Term] -id: CMPO:0000145 -name: increased thickness of dendritic branches phenotype -def: "A phenotype observation where the thickness of the dendritic branches has increased. " [] -subset: cmpo -is_a: CMPO:0000186 ! increased cell component size phenotype -property_value: prefLabel "increased thickness of dendritic branches" xsd:string - -[Term] -id: CMPO:0000146 -name: decreased thickness of dendritic branches -def: "A phenotype observation where the thickness of the dendritic branches has decreased. " [] -subset: cmpo -is_a: CMPO:0000187 ! decreased cell component size phenotype - -[Term] -id: CMPO:0000147 -name: disorganized microtubules phenotype -def: "A phenotype observation where the microtublue structure is disorganised" [] -subset: cmpo -synonym: "microtubule disorganised" EXACT [] -is_a: CMPO:0000012 ! cell component structure phenotype -is_a: CMPO:0000373 ! microtubule morphology phenotype -property_value: IAO:0000119 pmid:21893601 xsd:string -property_value: prefLabel "disorganized microtubules" xsd:string - -[Term] -id: CMPO:0000148 -name: podosome phenotype -def: "A phenotype observation at the level of podosomes, an actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell." [] -subset: cmpo -is_a: CMPO:0000020 ! cytoskeletal phenotype -property_value: prefLabel "podosome" xsd:string - -[Term] -id: CMPO:0000149 -name: radial cytoskeleton phenotype -def: "A phenotype observation where the cytoskeleton is symmetric, having equal proportions around a central point or axis." [] -subset: cmpo -is_a: CMPO:0000020 ! cytoskeletal phenotype -is_a: CMPO:0000065 ! cell component position phenotype -property_value: prefLabel "radial cytoskeleton" xsd:string - -[Term] -id: CMPO:0000150 -name: organelle phenotype -def: "Phenotype observation organised by specific named organelles." [] -subset: cmpo -is_a: CMPO:0000259 ! cellular component phenotype - -[Term] -id: CMPO:0000151 -name: fragmented endoplasmic reticulum phenotype -def: "A phenotype observation where the structure of the endoplasmic reticulum is fragmented or broken." [] -subset: cmpo -synonym: "broken endoplasmic reticulum" EXACT [] -is_a: CMPO:0000012 ! cell component structure phenotype -property_value: prefLabel "fragmented endoplasmic reticulum" xsd:string - -[Term] -id: CMPO:0000152 -name: fragmented golgi phenotype -def: "A phenotype observation at the level of the golgi where the golgi's structure is broken" [] -subset: cmpo -synonym: "broken golgi" EXACT [] -synonym: "broken golgi phenotype" EXACT [] -is_a: CMPO:0000012 ! cell component structure phenotype -property_value: prefLabel "fragmented golgi" xsd:string - -[Term] -id: CMPO:0000153 -name: fragmented mitochondria phenotype -def: "A phenotype observation where the structure of the mitochondria is fragmented or broken." [] -subset: cmpo -synonym: "broken mitochondria" EXACT [] -is_a: CMPO:0000012 ! cell component structure phenotype -property_value: prefLabel "fragmented mitochondria" xsd:string - -[Term] -id: CMPO:0000154 -name: bright nuclei phenotype -def: "A phenotype observation where the nuclear's color brightness is relatively high." [] -subset: cmpo -is_a: CMPO:0000024 ! nuclear phenotype -property_value: IAO:0000119 PMID:20531400 xsd:string -property_value: prefLabel "bright nuclei" xsd:string - -[Term] -id: CMPO:0000155 -name: fragmented nucleus phenotype -def: "A phenotype observation where the structure of the nucleus is fragmented or broken." [] -subset: cmpo -synonym: "broken nucleus" EXACT [] -is_a: CMPO:0000012 ! cell component structure phenotype -is_a: CMPO:0000249 ! nuclear morphology phenotype -property_value: prefLabel "fragmented nucleus" xsd:string - -[Term] -id: CMPO:0000156 -name: graped micronucleus phenotype -def: "A phenotype observation where nuclear envelopes form around single chromosomes or small sets of chromosomes. Forming a grape like structure" [] -comment: Mitocheck\nPublication: http://www.ncbi.nlm.nih.gov/pubmed/20360735\nMicronucleation, i.e. presumably nuclear envelopes around single chromosomes or small sets of chromosomes. -subset: cmpo -synonym: "grape" RELATED [] -is_a: CMPO:0000357 ! polylobed nuclear phenotype -property_value: IAO:0000119 pmid:20360735 xsd:string -property_value: prefLabel "graped micronucleus" xsd:string - -[Term] -id: CMPO:0000157 -name: abnormal nucleus shape phenotype -def: "A phenotype observation where the shape of the nucleus is abnormal" [] -subset: cmpo -synonym: "abnormal nuclear shape" EXACT [] -synonym: "strange nuclear shape" EXACT [] -is_a: CMPO:0000027 ! nucleus shape phenotype -property_value: IAO:0000119 PMID:20360735 xsd:string - -[Term] -id: CMPO:0000158 -name: decreased nuclei size in G2/M phenotype -def: "A phenotype observation at the level of the G2/M transition of the mitotic cell cycle where the nuclei are decreased in size with respect to normal" [] -subset: cmpo -is_a: CMPO:0000089 ! G2/M transition phenotype -is_a: CMPO:0000141 ! decreased nucleus size phenotype -relationship: BFO:0000051 CMPO:0000089 ! has_part G2/M transition phenotype -relationship: BFO:0000051 CMPO:0000141 ! has_part decreased nucleus size phenotype -property_value: prefLabel "decreased nuclei size in G2/M" xsd:string - -[Term] -id: CMPO:0000159 -name: absence of cellular component phenotype -def: "A phenotype observation at the level of a cellular component where the cell component is absent" [] -subset: cmpo -is_a: CMPO:0000008 ! cell component number phenotype -property_value: prefLabel "absence of cellular component" xsd:string - -[Term] -id: CMPO:0000160 -name: cell population viability phenotype -def: "A phenotype of a cell population relating to the ability of the cells to live and develop normally" [] -subset: cmpo -is_a: CMPO:0000002 ! cell population phenotype -property_value: prefLabel "cell viability in population phenotype" xsd:string - -[Term] -id: CMPO:0000161 -name: increased cell viability in population -def: "increased number of viable cell phenotype in a population" [] -subset: cmpo -is_a: CMPO:0000160 ! cell population viability phenotype -property_value: prefLabel "increased cell viability in population" xsd:string - -[Term] -id: CMPO:0000162 -name: decreased cell viability in population -def: "decreased number of viable cell phenotype in a population" [] -subset: cmpo -is_a: CMPO:0000160 ! cell population viability phenotype -property_value: prefLabel "decreased cell viability in population" xsd:string - -[Term] -id: CMPO:0000163 -name: cell population phenotype by morphology -def: "A population phenotype relating to the size, shape or structure of the cells within a population" [] -subset: cmpo -is_a: CMPO:0000002 ! cell population phenotype -property_value: prefLabel "cell population morphology" xsd:string - -[Term] -id: CMPO:0000164 -name: absence of cytokinesis phenotype -def: "A phenotype that results in the absence of cytokinesis" [] -subset: cmpo -is_a: CMPO:0000165 ! cytokinesis phenotype -is_a: CMPO:0000315 ! absence of cell process phenotype -property_value: prefLabel "absence of cytokinesis" xsd:string - -[Term] -id: CMPO:0000165 -name: cytokinesis phenotype -def: "A phenotype observation at the level of cytokinesis" [] -subset: cmpo -is_a: CMPO:0000029 ! cell cycle phenotype -is_a: CMPO:0000054 ! cell population phenotype by process -is_a: CMPO:0000166 ! cell division phenotype -property_value: prefLabel "cytokinesis phenotype" xsd:string - -[Term] -id: CMPO:0000166 -name: cell division phenotype -def: "A phenotype observation of the process resulting in the physical partitioning and separation of a cell into daughter cells." [] -subset: cmpo -is_a: CMPO:0000007 ! cell process phenotype -property_value: prefLabel "cell division phenotype" xsd:string - -[Term] -id: CMPO:0000168 -name: increased rate of cell division phenotype -def: "A phenotype where the cell division process occurs at a higher rate" [] -subset: cmpo -synonym: "faster cell division" EXACT [] -is_a: CMPO:0000166 ! cell division phenotype -property_value: prefLabel "increased rate of cell division" xsd:string - -[Term] -id: CMPO:0000169 -name: decreased rate of cell division phenotype -def: "A phenotype where the cell division process occurs at a lower rate" [] -subset: cmpo -synonym: "slower cell division" EXACT [] -is_a: CMPO:0000166 ! cell division phenotype -property_value: prefLabel "decreased rate of cell division" xsd:string - -[Term] -id: CMPO:0000170 -name: telomerase activity phenotype -def: "A phenotype observation of the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence." [] -subset: cmpo -is_a: CMPO:0000007 ! cell process phenotype -property_value: prefLabel "telomerase activity phenotype" xsd:string - -[Term] -id: CMPO:0000171 -name: decreased telomerase activity phenotype -def: "A phenotype observation where the occurane of telomerase activity is decreased" [] -subset: cmpo -is_a: CMPO:0000170 ! telomerase activity phenotype -property_value: prefLabel "decreased telomerase activity" xsd:string - -[Term] -id: CMPO:0000172 -name: increased telomerase activity phenotype -def: "A phenotype observation where the occurane of telomerase activity is increased" [] -subset: cmpo -is_a: CMPO:0000170 ! telomerase activity phenotype -property_value: prefLabel "increased telomerase activity" xsd:string - -[Term] -id: CMPO:0000173 -name: G0/1 arrested phenotype -def: "A phenotype of a cell that is arrested at the G0/1 transition" [] -comment: (from GO) Under certain conditions, cells exit the cell cycle during G1 and remain in the G0 state as nongrowing, non-dividing (quiescent) cells. -subset: cmpo -is_a: CMPO:0000029 ! cell cycle phenotype -is_a: CMPO:0000195 ! arrested process phenotype -property_value: prefLabel "G0/1 arrested" xsd:string - -[Term] -id: CMPO:0000174 -name: polarized endoplasmic reticulum phenotype -def: "A phenotype observation where the endoplasmic reticulum is oriented in the cell with extremities at either end of the main axis. " [] -subset: cmpo -synonym: "polarized endoplasmic reticulum" EXACT [] -is_a: CMPO:0000065 ! cell component position phenotype -property_value: prefLabel "polarized endoplasmic reticulum" xsd:string - -[Term] -id: CMPO:0000175 -name: molecular component phenotype -def: "A quality that inheres in a molecular component of a cell" [] -subset: cmpo -is_a: CMPO:0000003 ! cellular phenotype -property_value: prefLabel "molecular component phenotype" xsd:string - -[Term] -id: CMPO:0000176 -name: cell DNA phenotype -def: "A phenotype observation at the level of the cell DNA" [] -subset: cmpo -is_a: CMPO:0000175 ! molecular component phenotype -property_value: prefLabel "cell DNA phenotype" xsd:string - -[Term] -id: CMPO:0000177 -name: misshapen DNA -def: "A shape quality that inheres in a DNA molecule where the shape of the molecule is abnormal." [] -comment: This phenotype often results in a nucleus with an irregular shape phenotype. -subset: cmpo -is_a: CMPO:0000176 ! cell DNA phenotype - -[Term] -id: CMPO:0000180 -name: site of double-strand break phenotype -def: "A phenotype observation at the level of the site of double-strand break, a region of a chromosome at which a DNA double-strand break has occurred." [] -subset: cmpo -is_a: CMPO:0000150 ! organelle phenotype -property_value: prefLabel "site of double-strand break" xsd:string - -[Term] -id: CMPO:0000181 -name: decreased number of site of double-strand break phenotype -def: "A phenotype observation at the level of double strand breaks where the components number has decreased. " [] -subset: cmpo -is_a: CMPO:0000043 ! decreased cell component number phenotype -property_value: prefLabel "decreased number of site of double-strand break" xsd:string - -[Term] -id: CMPO:0000182 -name: increased number of site of double-strand break phenotype -def: "A phenotype observation where the number of double-strand breaks has increased" [] -subset: cmpo -is_a: CMPO:0000042 ! increased cell component number phenotype -property_value: prefLabel "increased number of site of double-strand break" xsd:string - -[Term] -id: CMPO:0000185 -name: cell-matrix adhesion phenotype -subset: cmpo -is_a: CMPO:0000028 ! cell adhesion phenotype -property_value: prefLabel "cell-matrix adhesion phenotype" xsd:string - -[Term] -id: CMPO:0000186 -name: increased cell component size phenotype -def: "A phenotype observation at the level of a cellular component where the components size has increased. " [] -subset: cmpo -is_a: CMPO:0000010 ! cell component size phenotype -property_value: prefLabel "increased cell component size" xsd:string - -[Term] -id: CMPO:0000187 -name: decreased cell component size phenotype -def: "A phenotype observation at the level of a cellular component where the components size has decreased. " [] -subset: cmpo -is_a: CMPO:0000010 ! cell component size phenotype -property_value: prefLabel "decreased cell component size" xsd:string - -[Term] -id: CMPO:0000188 -name: cell spreading phenotype -def: "A phenotype observation where the morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate." [] -subset: cmpo -synonym: "substrate adhesion-dependent cell spreading phenotype" EXACT [] -is_a: CMPO:0000028 ! cell adhesion phenotype -is_a: CMPO:0000054 ! cell population phenotype by process -is_a: CMPO:0000189 ! cellular development phenotype -property_value: prefLabel "cell spreading phenotype" xsd:string - -[Term] -id: CMPO:0000189 -name: cellular development phenotype -def: "A phenotype observation of a biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." [] -subset: cmpo -is_a: CMPO:0000007 ! cell process phenotype -property_value: prefLabel "cellular development phenotype" xsd:string - -[Term] -id: CMPO:0000190 -name: decreased number of axons phenotype -def: "A phenotype observation at the level of axons where the components number has decreased. " [] -subset: cmpo -is_a: CMPO:0000074 ! decreased number of cell projections phenotype -property_value: prefLabel "decreased number of axons" xsd:string - -[Term] -id: CMPO:0000191 -name: increased number of axons phenotype -def: "A phenotype observation at the level of axons where the components number has increased. " [] -subset: cmpo -is_a: CMPO:0000072 ! increased number of cell projections phenotype -property_value: prefLabel "increased number of axons" xsd:string - -[Term] -id: CMPO:0000194 -name: mitotic process phenotype -def: "A phenotype observation at the level of the mitotic cell cycle" [] -subset: cmpo -is_a: CMPO:0000029 ! cell cycle phenotype -property_value: prefLabel "mitotic process phenotype" xsd:string - -[Term] -id: CMPO:0000195 -name: arrested process phenotype -def: "A phenotype of a cell where a particular process is arrested, or ends earlier in time than expected" [] -subset: cmpo -is_a: CMPO:0000007 ! cell process phenotype -property_value: prefLabel "arrested process" xsd:string - -[Term] -id: CMPO:0000196 -name: M phase arrested phenotype -def: "A phenotype of a cell where the M phase of mitotic cell cycle process is arrested, or ends earlier in time than expected" [] -subset: cmpo -synonym: "m phase arrest" EXACT [] -synonym: "mitosis incomplete process phenotype" EXACT [] -synonym: "mitotic arrest" EXACT [] -is_a: CMPO:0000265 ! M phase mitotic phenotype -is_a: CMPO:0000304 ! cell cycle arrested phenotype -property_value: prefLabel "M phase arrested" xsd:string - -[Term] -id: CMPO:0000202 -name: mitosis delayed phenotype -def: "A phenotype observation where mitosis is delayed" [] -subset: cmpo -synonym: "Mitotic delay" EXACT [] -is_a: CMPO:0000194 ! mitotic process phenotype -is_a: CMPO:0000306 ! delayed process phenotype -property_value: IAO:0000119 PMID:20360735 xsd:string -property_value: prefLabel "mitosis delayed" xsd:string - -[Term] -id: CMPO:0000203 -name: G2 arrested phenotype -def: "A phenotype of a cell is arrested in G2 pahse of the cell cycle." [] -subset: cmpo -is_a: CMPO:0000207 ! G2 phase mitotic phenotype -is_a: CMPO:0000304 ! cell cycle arrested phenotype -property_value: prefLabel "G2 arrested" xsd:string - -[Term] -id: CMPO:0000204 -name: S phase arrested phenotype -def: "A phenotype of a cell where the S phase process is arrested, or ends earlier in time than expected" [] -subset: cmpo -is_a: CMPO:0000087 ! S phase mitotic phenotype -is_a: CMPO:0000304 ! cell cycle arrested phenotype -property_value: prefLabel "S phase arrested" xsd:string - -[Term] -id: CMPO:0000205 -name: increased duration of exit from mitosis phenotype -def: "A phenotype observation where the duration of the exit from mitosis is increased" [] -subset: cmpo -synonym: "prolonged mitotic exit" EXACT [] -is_a: CMPO:0000314 ! exit from mitosis phenotype -property_value: IAO:0000119 PMID:20711181 xsd:string -property_value: prefLabel "increased duration of exit from mitosis" xsd:string - -[Term] -id: CMPO:0000206 -name: decreased duration of exit from mitosis phenotype -subset: cmpo -is_a: CMPO:0000314 ! exit from mitosis phenotype -property_value: prefLabel "decreased duration of exit from mitosis" xsd:string - -[Term] -id: CMPO:0000207 -name: G2 phase mitotic phenotype -def: "A phenotype observation at the level of a G2 phase of the mitotic cell cycle" [] -subset: cmpo -is_a: CMPO:0000090 ! cell cycle phase phenotype -is_a: CMPO:0000194 ! mitotic process phenotype -property_value: prefLabel "G2 phase mitotic phenotype" xsd:string - -[Term] -id: CMPO:0000208 -name: mitotic metaphase phenotype -def: "A phenotype observation at the level of the mitotic metaphase of the cell cycle" [] -subset: cmpo -is_a: CMPO:0000090 ! cell cycle phase phenotype -is_a: CMPO:0000194 ! mitotic process phenotype -property_value: prefLabel "mitotic metaphase phenotype" xsd:string - -[Term] -id: CMPO:0000210 -name: more mitotic metaphase cells -def: "increased number of mitotic metaphase cells in population phenotype" [] -subset: cmpo -is_a: CMPO:0000051 ! increased cell numbers - -[Term] -id: CMPO:0000211 -name: fewer mitotic metaphase cells -def: "decreased number of mitotic metaphase cells in population phenotype" [] -subset: cmpo -is_a: CMPO:0000052 ! decreased cell numbers - -[Term] -id: CMPO:0000212 -name: abnormal cell cycle phenotype -def: "A phenotype where the cell cycle is in some way abnormal" [] -subset: cmpo -synonym: "altered level of protein in cell nucleus" EXACT [] -is_a: CMPO:0000029 ! cell cycle phenotype -property_value: prefLabel "abnormal cell cycle" xsd:string - -[Term] -id: CMPO:0000213 -name: binuclear cell phenotype -def: "A phenotype observation where a cell is binucleate, e.g. have two nuclei per cell" [] -subset: cmpo -synonym: "nuclei stay close together" EXACT [] -is_a: CMPO:0000018 ! multinucleated cell phenotype -property_value: prefLabel "binuclear cell" xsd:string - -[Term] -id: CMPO:0000214 -name: increased duration of mitotic chromosome condensation phenotype -def: "A phenotype observation where the duration of the mitotic chromosome condensation is increased" [] -subset: cmpo -synonym: "longer mitotic chromosome condensation" EXACT [] -is_a: CMPO:0000218 ! mitotic chromosome condensation phenotype -property_value: prefLabel "increased duration of mitotic chromosome condensation" xsd:string - -[Term] -id: CMPO:0000215 -name: decreased duration of mitotic chromosome condensation phenotype -def: "A phenotype observation where the duration of the mitotic chromosome condensation is decreased" [] -subset: cmpo -is_a: CMPO:0000218 ! mitotic chromosome condensation phenotype -property_value: prefLabel "decreased duration of mitotic chromosome condensation" xsd:string - -[Term] -id: CMPO:0000216 -name: absence of mitotic chromosome decondensation phenotype -def: "A phenotype resulting from the absence of mitotic chromosome decondensation" [] -subset: cmpo -synonym: "failure in decondensation" BROAD [] -is_a: CMPO:0000194 ! mitotic process phenotype -is_a: CMPO:0000315 ! absence of cell process phenotype -property_value: prefLabel "absence of mitotic chromosome decondensation" xsd:string - -[Term] -id: CMPO:0000217 -name: absence of mitotic process phenotype -def: "A phenotype resulting in the absence of mitotic process" [] -subset: cmpo -is_a: CMPO:0000315 ! absence of cell process phenotype -property_value: prefLabel "absence of mitotic process" xsd:string - -[Term] -id: CMPO:0000218 -name: mitotic chromosome condensation phenotype -def: "A phenotype observation at the level of mitotic chromosome condensation" [] -subset: cmpo -is_a: CMPO:0000194 ! mitotic process phenotype -property_value: prefLabel "mitotic chromosome condensation phenotype" xsd:string - -[Term] -id: CMPO:0000219 -name: mitotic chromosome decondensation phenotype -def: "A phenotype observation at the level of mitotic chromosome decondensation" [] -subset: cmpo -is_a: CMPO:0000054 ! cell population phenotype by process -is_a: CMPO:0000194 ! mitotic process phenotype -property_value: prefLabel "mitotic chromosome decondensation" xsd:string - -[Term] -id: CMPO:0000220 -name: cell apoptosis phenotype -def: "A phenotype where the apoptosis process is observed" [] -subset: cmpo -is_a: CMPO:0000030 ! cell death phenotype -property_value: prefLabel "cell apoptosis phenotype" xsd:string - -[Term] -id: CMPO:0000221 -name: more apoptosis in population -def: "increased number of apoptosis phenotypes in population" [] -subset: cmpo -is_a: CMPO:0000051 ! increased cell numbers - -[Term] -id: CMPO:0000222 -name: less apoptosis in population -def: "decreased number of apoptosis phenotypes in population" [] -subset: cmpo -is_a: CMPO:0000052 ! decreased cell numbers - -[Term] -id: CMPO:0000223 -name: increased axon thickness phenotype -def: "A phenotype observation where the thickness of the axon has increased. " [] -subset: cmpo -is_a: CMPO:0000186 ! increased cell component size phenotype -is_a: CMPO:0000280 ! cell projection phenotype -property_value: prefLabel "increased axon thickness" xsd:string - -[Term] -id: CMPO:0000224 -name: decreased axon thickness phenotype -def: "A phenotype observation where the thickness of the axon has decreased. " [] -subset: cmpo -is_a: CMPO:0000187 ! decreased cell component size phenotype -is_a: CMPO:0000280 ! cell projection phenotype -property_value: prefLabel "decresed axon thickness" xsd:string - -[Term] -id: CMPO:0000227 -name: increased axon length phenotype -def: "A phenotype observation at the level of a axon where the components length has increased. " [] -subset: cmpo -is_a: CMPO:0000186 ! increased cell component size phenotype -is_a: CMPO:0000280 ! cell projection phenotype -property_value: prefLabel "increased axon length" xsd:string - -[Term] -id: CMPO:0000228 -name: decreased axon length phenotype -def: "A phenotype observation at the level of a axon where the components length has decreased. " [] -subset: cmpo -is_a: CMPO:0000187 ! decreased cell component size phenotype -is_a: CMPO:0000280 ! cell projection phenotype -property_value: prefLabel "decreased axon length" xsd:string - -[Term] -id: CMPO:0000229 -name: plasma membrane fusion occurance phenotype -subset: cmpo -synonym: "cell fusion event" BROAD [] -is_a: CMPO:0000032 ! cell membrane organisation phenotype -property_value: prefLabel "plasma membrane fusion occurance" xsd:string - -[Term] -id: CMPO:0000232 -name: increased rate of cell migration process phenotype -def: "A phenotype where the cell migration process occurs at an increased rate, typically observed as a faster moving cell" [] -subset: cmpo -is_a: CMPO:0000033 ! cell migration phenotype -property_value: IAO:0000119 PMID:20360735 xsd:string -property_value: prefLabel "increased rate of cell migration process" xsd:string - -[Term] -id: CMPO:0000233 -name: decreased rate of cell migration process phenotype -def: "A phenotype where the cell migration process occurs at an redcued rate, typically observed as a slower moving cell" [] -subset: cmpo -synonym: "decreased speed of cell migration" NARROW [] -is_a: CMPO:0000033 ! cell migration phenotype -property_value: prefLabel "decreased rate of cell migration process" xsd:string - -[Term] -id: CMPO:0000234 -name: cell movement phenotype -def: "A phenotype observation at the level of the whole cell relating to the cell's movement" [] -subset: cmpo -is_a: CMPO:0000258 ! single cell phenotype -property_value: prefLabel "cell movement" xsd:string - -[Term] -id: CMPO:0000235 -name: increased cell movement phenotype -def: "A phenotype observation at the level of the cell movement where cell movement is increased" [] -subset: cmpo -is_a: CMPO:0000234 ! cell movement phenotype -property_value: prefLabel "increased cell movement" xsd:string - -[Term] -id: CMPO:0000236 -name: increased cell movement speed -def: "A phenotype observation at the level of the cell movement where the cell moves faster than normal/wild type." [] -subset: cmpo -synonym: "cell moves faster" EXACT [] -synonym: "increased cell migration speed" EXACT [] -is_a: CMPO:0000235 ! increased cell movement phenotype - -[Term] -id: CMPO:0000237 -name: increased cell movement distance -def: "A phenotype observation at the level of the cell movement where the distance travelled by the cell is increased. The distance is measured as the euclidean distance between start and end point of the cell trajectory." [] -subset: cmpo -synonym: "cells cover a longer distance" EXACT [] -synonym: "increased cell migration distance" EXACT [] -is_a: CMPO:0000235 ! increased cell movement phenotype - -[Term] -id: CMPO:0000238 -name: decreased cell movement phenotype -def: "A phenotype observation at the level of the cell movement where cell movement is decreased" [] -subset: cmpo -is_a: CMPO:0000234 ! cell movement phenotype -property_value: prefLabel "decreased cell movement" xsd:string - -[Term] -id: CMPO:0000239 -name: decreased cell movement distance -def: "A phenotype observation at the level of the cell movement where the distance travelled by the cell is decreased. The distance is measured as the euclidean distance between start and end point of the cell trajectory." [] -subset: cmpo -synonym: "cells cover a shorter distance" EXACT [] -is_a: CMPO:0000238 ! decreased cell movement phenotype - -[Term] -id: CMPO:0000240 -name: decreased cell movement speed -def: "A phenotype observation at the level of the cell movement where the cell moves slower than normal/wild type." [] -subset: cmpo -synonym: "cell moves slower" EXACT [] -is_a: CMPO:0000238 ! decreased cell movement phenotype - -[Term] -id: CMPO:0000241 -name: proliferating cells -def: "increased number of cells in population phenotype" [] -subset: cmpo -synonym: "high cell number in population" EXACT [] -synonym: "increased proliferation" EXACT [] -is_a: CMPO:0000051 ! increased cell numbers - -[Term] -id: CMPO:0000243 -name: actin-mediated cell contraction phenotype -def: "A phenotype of a cell contraction caused by an actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body." [] -subset: cmpo -synonym: "cell contraction" NARROW [] -is_a: CMPO:0000244 ! cell component movement phenotype -property_value: prefLabel "actin-mediated cell contraction" xsd:string - -[Term] -id: CMPO:0000244 -name: cell component movement phenotype -def: "A phenotype where the directed, self-propelled movement of a cellular component without the involvement of an external agent such as a transporter or a pore is observed" [] -subset: cmpo -is_a: CMPO:0000007 ! cell process phenotype -property_value: prefLabel "cell component movement" xsd:string - -[Term] -id: CMPO:0000245 -name: cell secretion phenotype -def: "A phenotype observation of the controlled release of a substance by a cell." [] -subset: cmpo -is_a: CMPO:0000041 ! transport phenotype -property_value: prefLabel "cell secretion phenotype" xsd:string - -[Term] -id: CMPO:0000246 -name: increased rate of protein secretion -def: "A phenotype observation where the rate of release of proteins from a cell is increased" [] -subset: cmpo -synonym: "enhanced protein secretion" BROAD [] -is_a: CMPO:0000245 ! cell secretion phenotype -property_value: IAO:0000119 PMID:22660414 xsd:string - -[Term] -id: CMPO:0000247 -name: decreased rate of protein secretion -def: "A phenotype observation where the rate of release of proteins from a cell is decreased" [] -subset: cmpo -synonym: "inhibition of protein secretion" BROAD [] -is_a: CMPO:0000245 ! cell secretion phenotype - -[Term] -id: CMPO:0000249 -name: nuclear morphology phenotype -def: "A phenotype observation at the level of the nucleus relating to the nuclear morphology" [] -subset: cmpo -is_a: CMPO:0000024 ! nuclear phenotype -is_a: CMPO:0000303 ! cell component morphology phenotype -property_value: prefLabel "nuclear morphology" xsd:string - -[Term] -id: CMPO:0000250 -name: golgi morphology phenotype -def: "A phenotype observation at the level of the golgi relating to the golgi's morphology" [] -subset: cmpo -is_a: CMPO:0000150 ! organelle phenotype -is_a: CMPO:0000303 ! cell component morphology phenotype -property_value: prefLabel "golgi morphology" xsd:string - -[Term] -id: CMPO:0000251 -name: cilium phenotype -def: "A phenotype observation at the level of the cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface." [] -subset: cmpo -is_a: CMPO:0000280 ! cell projection phenotype -property_value: prefLabel "cilium phenotype" xsd:string - -[Term] -id: CMPO:0000252 -name: cilium morphology phenotype -def: "A phenotype observation at the level of a cilium relating to the components shape, size or structure" [] -subset: cmpo -is_a: CMPO:0000251 ! cilium phenotype -is_a: CMPO:0000303 ! cell component morphology phenotype -property_value: prefLabel "cilium morphology" xsd:string - -[Term] -id: CMPO:0000258 -name: single cell phenotype -def: "A quality that inherers in a single or whole cell." [] -subset: cmpo -is_a: CMPO:0000259 ! cellular component phenotype -property_value: prefLabel "single cell phenotype" xsd:string - -[Term] -id: CMPO:0000259 -name: cellular component phenotype -def: "A quality that inheres in the cellular component of a cell" [] -subset: cmpo -is_a: CMPO:0000003 ! cellular phenotype -property_value: prefLabel "cellular component phenotype" xsd:string - -[Term] -id: CMPO:0000261 -name: geometric cell phenotype -def: "A phenotype observation at the level of the cell shape where the cell has a geometric shape with straight edges" [] -comment: request geometric shape in pato -subset: cmpo -is_a: CMPO:0000005 ! cell morphology phenotype -property_value: IAO:0000119 PMID:21893601 xsd:string -property_value: prefLabel "geometric cell" xsd:string - -[Term] -id: CMPO:0000262 -name: apoptotic DNA -def: "Fragmented and condensed DNA during or following apoptosis" [] -subset: cmpo -is_a: CMPO:0000176 ! cell DNA phenotype -property_value: prefLabel "apoptotic DNA" xsd:string - -[Term] -id: CMPO:0000263 -name: more cells in M phase -def: "Increased occurrence of mitotic cells" [] -subset: cmpo -synonym: "increased number of mitotic cells" EXACT [] -synonym: "increased occurrence of mitosis" EXACT [] -is_a: CMPO:0000051 ! increased cell numbers - -[Term] -id: CMPO:0000264 -name: fewer cells in M phase -def: "decreased occurrence of mitotic cells in population" [] -subset: cmpo -synonym: "decreased number of cell in mitosis" EXACT [] -synonym: "decreased number of mitotic cells" EXACT [] -synonym: "decreased occurrence of mitosis" EXACT [] -synonym: "less cells in M phase" EXACT [] -is_a: CMPO:0000052 ! decreased cell numbers - -[Term] -id: CMPO:0000265 -name: M phase mitotic phenotype -def: "A phenotype observation at the level of the M phase of the mitotic cell cycle" [] -subset: cmpo -is_a: CMPO:0000090 ! cell cycle phase phenotype -is_a: CMPO:0000194 ! mitotic process phenotype -property_value: prefLabel "M phase mitotic phenotype" xsd:string - -[Term] -id: CMPO:0000266 -name: asymmetric lamellipodia phenotype -def: "A phenotype observation where more lamellipoda is localised to one side of the cell with respect to the other" [] -subset: cmpo -synonym: "asymmetric lamellae" EXACT [] -is_a: CMPO:0000065 ! cell component position phenotype -is_a: CMPO:0000279 ! lamellipodium phenotype -property_value: IAO:0000119 PMID:21893601 xsd:string -property_value: prefLabel "asymmetric lamellipodia" xsd:string - -[Term] -id: CMPO:0000267 -name: star shaped cell phenotype -def: "A phenotype observation at the level of the cell shape where the cell has a star-like or bristly shape" [] -subset: cmpo -synonym: "spiky cell" BROAD [] -is_a: CMPO:0000005 ! cell morphology phenotype -is_a: CMPO:0000011 ! cell component shape phenotype -property_value: IAO:0000119 PMID:21893601 xsd:string -property_value: prefLabel "star shaped cell" xsd:string - -[Term] -id: CMPO:0000268 -name: spiny shaped cell phenotype -def: "A phenotype observation at the level of the cell shape where the cell has a star-like or bristly shape" [] -subset: cmpo -is_a: CMPO:0000005 ! cell morphology phenotype -is_a: CMPO:0000011 ! cell component shape phenotype -property_value: IAO:0000119 PMID:21893601 xsd:string -property_value: prefLabel "spiny shaped cell" xsd:string - -[Term] -id: CMPO:0000269 -name: increased variability of cell size in population -def: "A population of cells where the cells exhibit a high variability of size" [] -subset: cmpo -synonym: "variable cell size" EXACT [] -is_a: CMPO:0000163 ! cell population phenotype by morphology - -[Term] -id: CMPO:0000270 -name: increased variability of cell shape in population -def: "A population of cells where the cells exhibit a high variability of shape" [] -subset: cmpo -synonym: "variable cell shape" EXACT [] -is_a: CMPO:0000163 ! cell population phenotype by morphology - -[Term] -id: CMPO:0000271 -name: cortical actin cytoskeleton phenotype -subset: cmpo -synonym: "peripheral actin phenotype" EXACT [] -is_a: CMPO:0000020 ! cytoskeletal phenotype -property_value: IAO:0000119 "A phenotype observation at the level of the cortical actin cytoskeleton, the portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane." xsd:string -property_value: prefLabel "cortical actin cytoskeleton phenotype" xsd:string - -[Term] -id: CMPO:0000272 -name: increased cortical actin cytoskeleton mass phenotype -def: "A phenotype observation at the level of the cortical actin cytoskeleton where the components mass has increased. " [] -subset: cmpo -synonym: "increased peripheral actin" EXACT [] -is_a: CMPO:0000271 ! cortical actin cytoskeleton phenotype -property_value: IAO:0000119 PMID:21893601 xsd:string -property_value: prefLabel "increased cortical actin cytoskeleton mass" xsd:string - -[Term] -id: CMPO:0000273 -name: decreased cortical actin cytoskeleton mass phenotype -def: "A phenotype observation at the level of the cortical actin cytoskeleton where the components mass has decreased. " [] -subset: cmpo -synonym: "decreased peripheral actin" EXACT [] -is_a: CMPO:0000271 ! cortical actin cytoskeleton phenotype -property_value: IAO:0000119 PMID:21893601 xsd:string -property_value: prefLabel "decreased cortical actin cytoskeleton mass" xsd:string - -[Term] -id: CMPO:0000274 -name: disorganised cortical actin cytoskeleton phenotype -def: "A phenotype observation at the level of the cortical actin cytoskeleton where the component shows an irregular organization" [] -subset: cmpo -synonym: "disorganised peripheral actin phenotype" EXACT [] -is_a: CMPO:0000012 ! cell component structure phenotype -is_a: CMPO:0000271 ! cortical actin cytoskeleton phenotype -property_value: IAO:0000119 PMID:21893601 xsd:string -property_value: prefLabel "disorganised cortical actin cytoskeleton" xsd:string - -[Term] -id: CMPO:0000276 -name: increased lamellipodia width phenotype -def: "A phenotype observation at the level of a lamellipodia where the components width has increased. " [] -subset: cmpo -synonym: "increased width of lamellae" EXACT [] -is_a: CMPO:0000186 ! increased cell component size phenotype -is_a: CMPO:0000279 ! lamellipodium phenotype -property_value: IAO:0000119 PMID:21893601 xsd:string -property_value: prefLabel "increased lamellipodia width" xsd:string - -[Term] -id: CMPO:0000277 -name: decreased lamellipodia width phenotype -def: "A phenotype observation at the level of a lamellipodia where the components width has decreased. " [] -subset: cmpo -synonym: "decreased width of lamellae" EXACT [] -is_a: CMPO:0000187 ! decreased cell component size phenotype -is_a: CMPO:0000279 ! lamellipodium phenotype -property_value: IAO:0000119 PMID:21893601 xsd:string -property_value: prefLabel "decreased lamellipodia width" xsd:string - -[Term] -id: CMPO:0000278 -name: fan-shaped lamellipodia phenotype -def: "A phenotype observation where the lamellipodia is shaped in the form of a fan." [] -subset: cmpo -synonym: "motile lamellae" BROAD [] -is_a: CMPO:0000011 ! cell component shape phenotype -is_a: CMPO:0000279 ! lamellipodium phenotype -property_value: IAO:0000119 PMID:21893601 xsd:string -property_value: prefLabel "fan-shaped lamellipodia" xsd:string - -[Term] -id: CMPO:0000279 -name: lamellipodium phenotype -def: "A phenotype observation at the level of a cell with an increased amount of lamellipodia. " [] -subset: cmpo -is_a: CMPO:0000280 ! cell projection phenotype -property_value: prefLabel "lamellipodium phenotype" xsd:string - -[Term] -id: CMPO:0000280 -name: cell projection phenotype -def: "A phenotype observation at the level of a cellular component relating to a prolongation or process extending from a cell, e.g. a cilium, lamellipodium or axon." [] -subset: cmpo -is_a: CMPO:0000259 ! cellular component phenotype -property_value: prefLabel "cell projection phenotype" xsd:string - -[Term] -id: CMPO:0000281 -name: filopodium phenotype -def: "A phenotype observation at the level of the filopodium; a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast." [] -subset: cmpo -is_a: CMPO:0000280 ! cell projection phenotype -property_value: prefLabel "filopodium" xsd:string - -[Term] -id: CMPO:0000282 -name: layered cells in population -def: "Cells not stopping at confluence and growing on top of each other in layers" [] -subset: cmpo -synonym: "layered cells" BROAD [] -is_a: CMPO:0000163 ! cell population phenotype by morphology -property_value: IAO:0000119 PMID:21893601 xsd:string - -[Term] -id: CMPO:0000283 -name: actin cytoskeleton phenotype -def: "A phenotype observation at the level of the actin cytoskeleton, the part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [] -subset: cmpo -is_a: CMPO:0000020 ! cytoskeletal phenotype -property_value: prefLabel "actin cytoskeleton" xsd:string - -[Term] -id: CMPO:0000284 -name: increased actin cytoskeleton mass phenotype -def: "A phenotype observation at the level of a actin cytoskeleton where the components mass has increased" [] -subset: cmpo -is_a: CMPO:0000283 ! actin cytoskeleton phenotype -property_value: IAO:0000119 PMID:21893601 xsd:string -property_value: prefLabel "increased actin cytoskeleton mass" xsd:string - -[Term] -id: CMPO:0000285 -name: decreased actin cytoskeleton mass phenotype -def: "A phenotype observation at the level of a actin cytoskeleton where the components mass has decreased. " [] -subset: cmpo -is_a: CMPO:0000283 ! actin cytoskeleton phenotype -property_value: IAO:0000119 PMID:21893601 xsd:string -property_value: prefLabel "decreased actin cytoskeleton mass" xsd:string - -[Term] -id: CMPO:0000286 -name: aggregated microtubules phenotype -subset: cmpo -synonym: "microtubule clumps" EXACT [] -is_a: CMPO:0000020 ! cytoskeletal phenotype -is_a: CMPO:0000065 ! cell component position phenotype -property_value: IAO:0000119 "A phenotype observation where microtubules form clump-like structures as opposed to filaments" xsd:string -property_value: IAO:0000119 PMID:21893601 xsd:string -property_value: prefLabel "aggregated microtubules" xsd:string - -[Term] -id: CMPO:0000287 -name: microtubules nuclear bracket phenotype -def: "A phenotype observation where the microtubules form two crescent shaped brackets around the nucleus" [] -subset: cmpo -is_a: CMPO:0000020 ! cytoskeletal phenotype -is_a: CMPO:0000065 ! cell component position phenotype -property_value: IAO:0000119 PMID:21893601 xsd:string -property_value: prefLabel "microtubules nuclear bracket" xsd:string - -[Term] -id: CMPO:0000288 -name: microtubules nuclear ring phenotype -def: "A phenotype observation where the microtubules form a ring around the nucleus" [] -subset: cmpo -synonym: "microtubule nuclear ring" EXACT [] -is_a: CMPO:0000020 ! cytoskeletal phenotype -is_a: CMPO:0000065 ! cell component position phenotype -property_value: IAO:0000119 PMID:21893601 xsd:string -property_value: prefLabel "microtubules nuclear ring" xsd:string - -[Term] -id: CMPO:0000289 -name: increased amount of stress fibers phenotype -def: "A phenotype observation at the level of any stress fibers where the components number has increased. " [] -subset: cmpo -synonym: "more actin stress fibers" EXACT [] -is_a: CMPO:0000042 ! increased cell component number phenotype -property_value: IAO:0000119 pmid:21893601 xsd:string -property_value: prefLabel "increased amount of stress fibers" xsd:string - -[Term] -id: CMPO:0000290 -name: punctate actin foci phenotype -def: "A phenotype observation where actin is observed as small patches or spots all over the cell" [] -subset: cmpo -synonym: "puncta actin filament phenotype" EXACT [] -is_a: CMPO:0000065 ! cell component position phenotype -is_a: CMPO:0000104 ! actin filament phenotype -property_value: prefLabel "punctate actin foci" xsd:string - -[Term] -id: CMPO:0000291 -name: increased amount of punctate actin foci phenotype -def: "A phenotype observation where a cell has an increased amount of actin observed as small patches or spots all over the cell" [] -subset: cmpo -synonym: "increased actin puncta" EXACT [] -synonym: "more actin puncta" EXACT [] -is_a: CMPO:0000105 ! increased number of actin filament phenotype -property_value: IAO:0000119 PMID:21893601 xsd:string -property_value: prefLabel "increased amount of punctate actin foci" xsd:string - -[Term] -id: CMPO:0000292 -name: cell population layer phenotype -def: "A phenotype of a culture in which cells grow as a monolayer that is attached to the culture substrate." [] -subset: cmpo -is_a: CMPO:0000002 ! cell population phenotype -property_value: IAO:0000119 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20216 xsd:string -property_value: prefLabel "cell layer phenotype" xsd:string - -[Term] -id: CMPO:0000293 -name: loss of cell monolayer -def: "Loss of sheet like monolayer leading to empty patches" [] -subset: cmpo -synonym: "lost cell monolayer" EXACT [] -is_a: CMPO:0000292 ! cell population layer phenotype -property_value: prefLabel "loss of cell monolayer" xsd:string - -[Term] -id: CMPO:0000294 -name: increased actin localised to the nucleus -def: "A phenotype observation where many actin filaments are observed in or around the nucleus" [] -subset: cmpo -synonym: "increased nuclear actin" EXACT [] -is_a: CMPO:0000104 ! actin filament phenotype -is_a: CMPO:0000356 ! cell component localization phenotype -property_value: IAO:0000119 "PMID: 21893601" xsd:string - -[Term] -id: CMPO:0000296 -name: increased actin localised to the cytoplasm -def: "A phenotype observation where many actin filaments are observed in the cytoplasm" [] -subset: cmpo -synonym: "increased cytoplasmic actin" EXACT [] -is_a: CMPO:0000104 ! actin filament phenotype -is_a: CMPO:0000356 ! cell component localization phenotype -property_value: IAO:0000119 "PMID: 21893601" xsd:string - -[Term] -id: CMPO:0000297 -name: increased amount of stress fibers located in the cell cortex phenotype -comment: Increased amount of actin stress fibers in the cortical area -subset: cmpo -synonym: "more cortical actin stress fibers" BROAD [] -is_a: CMPO:0000289 ! increased amount of stress fibers phenotype -property_value: IAO:0000119 "A phenotype observation at the level of stress fibers localized to the cell cortex where the components number has increased. " xsd:string -property_value: IAO:0000119 pmid:21893601 xsd:string -property_value: prefLabel "increased amount of stress fibers located in the cell cortex" xsd:string - -[Term] -id: CMPO:0000298 -name: increased amount of transverse stress fibers -def: "A phenotype observation at the level of stress fibers where the components number has increased and formed transverse arcs which are located in the cell cortex" [] -comment: Increased amount of actin stress fibers, forming transverse arcs located in the cell cortex -subset: cmpo -synonym: "more transverse actin stress fibers" EXACT [] -is_a: CMPO:0000289 ! increased amount of stress fibers phenotype -property_value: IAO:0000119 pmid:21893601 xsd:string - -[Term] -id: CMPO:0000299 -name: increased amount of zig-zag stress fibers -def: "A phenotype observation at the level of stress fibers where the components number has increased and formed a zig zag pattern across the cell" [] -comment: Increased amount of actin stress fibers, with zig-zag pattern across the cell -subset: cmpo -synonym: "more zig-zag actin stress fibers" EXACT [] -is_a: CMPO:0000289 ! increased amount of stress fibers phenotype -property_value: IAO:0000119 pmid:21893601 xsd:string - -[Term] -id: CMPO:0000300 -name: more multinucleate cells -def: "Increased cells that are multinucleated" [] -subset: cmpo -is_a: CMPO:0000051 ! increased cell numbers - -[Term] -id: CMPO:0000301 -name: no cells phenotype -def: "Absence of cells" [] -subset: cmpo -is_a: CMPO:0000002 ! cell population phenotype -property_value: IAO:0000119 PMID:21893601 xsd:string -property_value: prefLabel "no cells" xsd:string - -[Term] -id: CMPO:0000302 -name: actin nuclear ring phenotype -def: "A phenotype observation where the microtubules form a ring around the nucleus" [] -subset: cmpo -synonym: "nuclear actin ring" EXACT [] -is_a: CMPO:0000065 ! cell component position phenotype -is_a: CMPO:0000104 ! actin filament phenotype -property_value: IAO:0000119 PMID:21893601 xsd:string -property_value: prefLabel "actin nuclear ring" xsd:string - -[Term] -id: CMPO:0000303 -name: cell component morphology phenotype -def: "A phenotype observation at the level of a cellular component relating to the components shape, size or structure" [] -subset: cmpo -is_a: CMPO:0000259 ! cellular component phenotype -property_value: prefLabel "cell component morphology" xsd:string - -[Term] -id: CMPO:0000304 -name: cell cycle arrested phenotype -def: "A phenotype of a cell where a particular process is arrested, or ends earlier in time than expected" [] -subset: cmpo -is_a: CMPO:0000029 ! cell cycle phenotype -is_a: CMPO:0000090 ! cell cycle phase phenotype -is_a: CMPO:0000195 ! arrested process phenotype -property_value: prefLabel "cell cycle arrested" xsd:string - -[Term] -id: CMPO:0000305 -name: metaphase arrested phenotype -def: "A phenotype of a cell arrested in mitotic metaphase" [] -subset: cmpo -synonym: "metaphase arrest" EXACT [] -is_a: CMPO:0000208 ! mitotic metaphase phenotype -is_a: CMPO:0000304 ! cell cycle arrested phenotype -property_value: IAO:0000119 PMID:20360735 xsd:string -property_value: prefLabel "metaphase arrested" xsd:string - -[Term] -id: CMPO:0000306 -name: delayed process phenotype -def: "A phenotype of a cell where a particular process is delayed" [] -subset: cmpo -is_a: CMPO:0000007 ! cell process phenotype -is_a: CMPO:0000054 ! cell population phenotype by process -property_value: prefLabel "delayed process" xsd:string - -[Term] -id: CMPO:0000307 -name: metaphase delayed phenotype -def: "A phenotype of a cell where mitotic metaphase is delayed" [] -subset: cmpo -synonym: "metaphase delay" EXACT [] -is_a: CMPO:0000208 ! mitotic metaphase phenotype -is_a: CMPO:0000306 ! delayed process phenotype -property_value: IAO:0000119 PMID:20360735 xsd:string -property_value: prefLabel "metaphase delayed" xsd:string - -[Term] -id: CMPO:0000309 -name: impaired cell migration -def: "A phenotype where the cell migration is impaired" [] -subset: cmpo -synonym: "abnormal cell migration" EXACT [] -is_a: CMPO:0000033 ! cell migration phenotype - -[Term] -id: CMPO:0000312 -name: increased duration of cell migration process phenotype -def: "A phenotype where the cell migration process occurs for longer, typically observed as a cell moving a further distance" [] -subset: cmpo -is_a: CMPO:0000033 ! cell migration phenotype -property_value: IAO:0000119 PMID:20360735 xsd:string -property_value: prefLabel "increased duration of cell migration process" xsd:string - -[Term] -id: CMPO:0000313 -name: decreased duration of cell migration process phenotype -def: "A phenotype where the cell migration process duration is reduced, typically observed as a cell moving a shorter distance" [] -subset: cmpo -is_a: CMPO:0000033 ! cell migration phenotype -property_value: prefLabel "decreased duration of cell migration process" xsd:string - -[Term] -id: CMPO:0000314 -name: exit from mitosis phenotype -def: "A phenotype observation at the level of the exit from mitosis" [] -subset: cmpo -is_a: CMPO:0000194 ! mitotic process phenotype -property_value: prefLabel "exit from mitosis" xsd:string - -[Term] -id: CMPO:0000315 -name: absence of cell process phenotype -def: "A phenotype observation at the level of a cellular process where the cell process is absent" [] -subset: cmpo -synonym: "cell physiology phenotype" EXACT [] -is_a: CMPO:0000007 ! cell process phenotype -is_a: CMPO:0000054 ! cell population phenotype by process -property_value: prefLabel "absence of cell process" xsd:string - -[Term] -id: CMPO:0000316 -name: abnormal cell growth phenotype -def: "A phenotype observation of the process in which the cell growth is abnormal" [] -subset: cmpo -is_a: CMPO:0000035 ! cell growth phenotype -property_value: prefLabel "abnormal cell growth" xsd:string - -[Term] -id: CMPO:0000317 -name: cell growth arrested phenotype -def: "A phenotype observation of the process in which the cell growth is arrested" [] -subset: cmpo -is_a: CMPO:0000035 ! cell growth phenotype -is_a: CMPO:0000195 ! arrested process phenotype -property_value: prefLabel "cell growth arrested" xsd:string - -[Term] -id: CMPO:0000318 -name: mild decrease in rate of protein secretion -def: "A phenotype observation where the rate of release of proteins from a cell is mildly decreased" [] -subset: cmpo -synonym: "mild inhibition of protein secretion" BROAD [] -is_a: CMPO:0000247 ! decreased rate of protein secretion -property_value: IAO:0000119 PMID:22660414 xsd:string - -[Term] -id: CMPO:0000319 -name: strong decrease in rate of protein secretion -def: "A phenotype observation where the rate of release of proteins from a cell is severly decreased" [] -subset: cmpo -synonym: "strong inhibition of protein secretion" BROAD [] -is_a: CMPO:0000247 ! decreased rate of protein secretion -property_value: IAO:0000119 PMID:22660414 xsd:string - -[Term] -id: CMPO:0000320 -name: increased cell spreading phenotype -def: "A phenotype observation where there is an increased occurance of cell spreading" [] -subset: cmpo -is_a: CMPO:0000188 ! cell spreading phenotype -property_value: prefLabel "increased cell spreading" xsd:string - -[Term] -id: CMPO:0000321 -name: mild increase of cell spreading phenotype -def: "A phenotype observation where there is a mild increase of cell spreading" [] -subset: cmpo -synonym: "moderate cell spreading" BROAD [] -is_a: CMPO:0000320 ! increased cell spreading phenotype -property_value: IAO:0000119 PMID:19667130 xsd:string -property_value: prefLabel "mild increase of cell spreading" xsd:string - -[Term] -id: CMPO:0000322 -name: strong increase of cell spreading phenotype -def: "A phenotype observation where there is a severe increase in cell spreading" [] -subset: cmpo -synonym: "extensive cell spreading" BROAD [] -is_a: CMPO:0000320 ! increased cell spreading phenotype -property_value: prefLabel "strong increase of cell spreading" xsd:string - -[Term] -id: CMPO:0000323 -name: decreased cell spreading phenotype -def: "A phenotype observation where there is a decreased occurance of cell spreading" [] -subset: cmpo -synonym: "poor cell spreading" BROAD [] -is_a: CMPO:0000188 ! cell spreading phenotype -property_value: IAO:0000119 PMID:19667130 xsd:string -property_value: prefLabel "decreased cell spreading" xsd:string - -[Term] -id: CMPO:0000324 -name: absence of cell spreading phenotype -def: "A phenotype observation where cell spreading is absent" [] -subset: cmpo -synonym: "no spreading cells" EXACT [] -is_a: CMPO:0000188 ! cell spreading phenotype -is_a: CMPO:0000315 ! absence of cell process phenotype -property_value: prefLabel "absence of cell spreading" xsd:string - -[Term] -id: CMPO:0000325 -name: spread cell morphology phenotype -def: "A phenotype observation where a cell shows a thin and large projected areas, with developed matrix adhesions at the cell periphery, as opposed to round cells with no or few adhesion sites" [] -subset: cmpo -synonym: "spreading cell shape" EXACT [] -is_a: CMPO:0000005 ! cell morphology phenotype -property_value: prefLabel "spread cell morphology" xsd:string - -[Term] -id: CMPO:0000326 -name: abnormal chromosome segregation phenotype -def: "A phenotype observation of the process in which the chromosome segregation is abnormal" [] -subset: cmpo -synonym: "chromatin bridges" BROAD [] -synonym: "lagging chromosomes" BROAD [] -synonym: "multiple DNA masses" BROAD [] -synonym: "segregation problems" BROAD [] -is_a: CMPO:0000036 ! chromosome segregation phenotype -property_value: IAO:0000119 PMID:20360735 xsd:string -property_value: prefLabel "abnormal chromosome segregation" xsd:string - -[Term] -id: CMPO:0000327 -name: mitotic prophase phenotype -def: "A phenotype observation at the level of the mitotic prophase of the cell cycle" [] -subset: cmpo -is_a: CMPO:0000090 ! cell cycle phase phenotype -is_a: CMPO:0000194 ! mitotic process phenotype -property_value: prefLabel "mitotic prophase phenotype" xsd:string - -[Term] -id: CMPO:0000328 -name: increased duration of mitotic prophase phenotype -def: "A phenotype observation where the duration of the mitotic prophase of the cell cycle is increased" [] -subset: cmpo -is_a: CMPO:0000327 ! mitotic prophase phenotype -property_value: prefLabel "increased duration of mitotic prophase" xsd:string - -[Term] -id: CMPO:0000329 -name: decreased duration of mitotic prophase phenotype -def: "A phenotype observation where the duration of the mitotic prophase of the cell cycle is decreased" [] -subset: cmpo -is_a: CMPO:0000327 ! mitotic prophase phenotype -property_value: prefLabel "decreased duration of mitotic prophase" xsd:string - -[Term] -id: CMPO:0000330 -name: decreased frequency of negative regulation of NF-kappaB transcription factor activity phenotype -def: "A phenotype observation where the frequency of a process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB is decreased." [] -subset: cmpo -synonym: "decreased NF-kB oscillation" RELATED [] -is_a: CMPO:0000039 ! regulation of metabolic process phenotype -property_value: IAO:0000116 "decreased number of oscillations; the amplitude of the first peak is comparable to control, although the duration may be increased; the time of the second and third peaks is delayed, due to greater interval times between termination and initiation of nuclear translocation responses" xsd:string -property_value: IAO:0000119 PMID:23300644 xsd:string -property_value: prefLabel "decreased frequency of negative regulation of NF-kappaB transcription factor activity" xsd:string - -[Term] -id: CMPO:0000331 -name: increased frequency of negative regulation of NF-kappaB transcription factor activity phenotype -def: "A phenotype observation where the frequency of a process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB is increased." [] -subset: cmpo -synonym: "increased NF-kB oscillation" RELATED [] -is_a: CMPO:0000039 ! regulation of metabolic process phenotype -property_value: IAO:0000116 "increased number of oscillations; the amplitude of the second and third peak is increased and nuclear translocation responses occur at increased intervals." xsd:string -property_value: IAO:0000119 PMID:23300644 xsd:string -property_value: prefLabel "increased frequency of negative regulation of NF-kappaB transcription factor activity" xsd:string - -[Term] -id: CMPO:0000332 -name: cytoplasmic sequestering of NF-kappaB phenotype -def: "A phenotype observation where the frequency of a process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB is increased." [] -subset: cmpo -synonym: "no NF-kB oscillation phenotype" RELATED [] -is_a: CMPO:0000040 ! regulation of signal transduction phenotype -is_a: CMPO:0000356 ! cell component localization phenotype -is_a: CMPO:0000435 ! negative regulation of protein import into nucleus phenotype -property_value: IAO:0000116 "increased number of oscillations; the amplitude of the second and third peak is increased and nuclear translocation responses occur at increased intervals." xsd:string -property_value: IAO:0000119 PMID:23300644 xsd:string -property_value: prefLabel "cytoplasmic sequestering of NF-kappaB" xsd:string - -[Term] -id: CMPO:0000333 -name: abnormal release of cytoplasmic sequestered NF-kappaB phenotype -def: "A phenotype observation where the release of NF-kappaB from specific molecules in the cytoplasm to which it was bound, thereby allowing its translocation into the nucleus, is abnormal." [] -subset: cmpo -synonym: "different NF-kB oscillation phenotype" RELATED [] -is_a: CMPO:0000040 ! regulation of signal transduction phenotype -is_a: CMPO:0000436 ! positive regulation of protein import into nucleus phenotype -property_value: IAO:0000116 "contains all cases that are significantly different from the rest, but don't share any clear commonalities. NF-kB oscillation patterns are not synchronized within a cell population, oscillation amplitude and frequency follow erratic patterns" xsd:string -property_value: IAO:0000119 PMID:23300644 xsd:string -property_value: prefLabel "abnormal release of cytoplasmic sequestered NF-kappaB" xsd:string - -[Term] -id: CMPO:0000334 -name: regulation of process phenotype -def: "A phenotype observation where any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [] -subset: cmpo -is_a: CMPO:0000007 ! cell process phenotype -property_value: prefLabel "regulation of process phenotype" xsd:string - -[Term] -id: CMPO:0000335 -name: bright nuclear body phenotype -def: "A phenotype obervation where the nuclear body's color brightness is relatively high." [] -subset: cmpo -synonym: "increased intensity of nuclear body" RELATED [] -is_a: CMPO:0000125 ! nuclear body phenotype -property_value: IAO:0000119 pmid:22884692 xsd:string -property_value: prefLabel "bright nuclear body" xsd:string - -[Term] -id: CMPO:0000337 -name: round focal adhesion -def: "A phenotype observation where the shape of the focal adhesion has every part of the surface or the circumference equidistant from the center." [] -subset: cmpo -is_a: CMPO:0000011 ! cell component shape phenotype - -[Term] -id: CMPO:0000338 -name: mitosis arrested -def: "A phenotype of a cell that is arrested at mitosis" [] -subset: cmpo -synonym: "mitotic arrest" EXACT [] -is_a: CMPO:0000194 ! mitotic process phenotype -is_a: CMPO:0000195 ! arrested process phenotype -property_value: IAO:0000119 PMID:20360735 xsd:string - -[Term] -id: CMPO:0000340 -name: increased cell size in population -def: "A population of cells where there is an increased number of large cells in the population" [] -subset: cmpo -synonym: "large cells" EXACT [] -is_a: CMPO:0000051 ! increased cell numbers -is_a: CMPO:0000163 ! cell population phenotype by morphology -property_value: prefLabel "increased cell size in population" xsd:string - -[Term] -id: CMPO:0000341 -name: pyknotic nuclear phenotype -def: "A phenotype observation at the level of the nucleus underoging Pyknosis, or karyopyknosis, consisting of the irreversible condensation of chromatin in the nucleus of a cell undergoing necrosis or apoptosis." [] -subset: cmpo -synonym: "pyknotic cell" BROAD [] -synonym: "pyknotic nucleus" EXACT [] -is_a: CMPO:0000024 ! nuclear phenotype - -[Term] -id: CMPO:0000343 -name: prometaphase arrested phenotype -def: "A phenotype of a cell arrested in mitotic prometaphase" [] -subset: cmpo -synonym: "prometaphase arrest" EXACT [] -is_a: CMPO:0000194 ! mitotic process phenotype -is_a: CMPO:0000304 ! cell cycle arrested phenotype -property_value: prefLabel "prometaphase arrested" xsd:string - -[Term] -id: CMPO:0000344 -name: prometaphase delayed phenotype -def: "A phenotype of a cell where mitotic prometaphase is delayed" [] -subset: cmpo -synonym: "prometaphase delay" EXACT [] -is_a: CMPO:0000090 ! cell cycle phase phenotype -is_a: CMPO:0000194 ! mitotic process phenotype -is_a: CMPO:0000306 ! delayed process phenotype -property_value: prefLabel "prometaphase delayed" xsd:string - -[Term] -id: CMPO:0000345 -name: increased variability of nuclear shape in population -def: "A population of cells where the nuclei exhibit a high variability of shape" [] -subset: cmpo -synonym: "variable cell shape" EXACT [] -is_a: CMPO:0000163 ! cell population phenotype by morphology - -[Term] -id: CMPO:0000346 -name: decreased rate of intracellular protein transport phenotype -def: "A phenotype observation where the rate of intracellular protein transport is decreased" [] -subset: cmpo -is_a: CMPO:0000041 ! transport phenotype -property_value: IAO:0000119 pmid:21795383 xsd:string -property_value: prefLabel "decreased rate of intracellular protein transport" xsd:string - -[Term] -id: CMPO:0000347 -name: absence of mitotic metaphase process phenotype -def: "A phenotype resulting in the absence of mitotic metaphase process" [] -subset: cmpo -is_a: CMPO:0000194 ! mitotic process phenotype -is_a: CMPO:0000315 ! absence of cell process phenotype -property_value: prefLabel "absence of mitotic metaphase" xsd:string - -[Term] -id: CMPO:0000348 -name: mitotic metaphase plate congression phenotype -def: "A phenotype observation at the level of the cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis." [] -subset: cmpo -synonym: "metaphase alignment problem" BROAD [] -is_a: CMPO:0000038 ! organelle localization phenotype -is_a: CMPO:0000194 ! mitotic process phenotype -property_value: prefLabel "mitotic metaphase plate congression" xsd:string - -[Term] -id: CMPO:0000349 -name: increased substrate-dependent cell migration, cell extension phenotype -def: "A phenotype where an increased formation of a cell surface protrusion, such as a lamellipodium or filopodium, at the leading edge of a migrating cell is observed." [] -subset: cmpo -synonym: "increased protrusive activity" EXACT [] -is_a: CMPO:0000033 ! cell migration phenotype -property_value: prefLabel "increased substrate-dependent cell migration, cell extension" xsd:string - -[Term] -id: CMPO:0000350 -name: increased substrate-dependent cell migration phenotype -def: "A phenotype where an increased occurrence of the orderly movement of a cell from one site to another along a substrate such as the extracellular matrix is observed." [] -subset: cmpo -synonym: "increased directional cell migration" EXACT [] -is_a: CMPO:0000033 ! cell migration phenotype -property_value: prefLabel "increased substrate-dependent cell migration" xsd:string - -[Term] -id: CMPO:0000351 -name: increased microtubule-based processes phenotype -def: "A phenotype where an increased occurance of any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins, is observed." [] -subset: cmpo -synonym: "microtubule processes" EXACT [] -is_a: CMPO:0000007 ! cell process phenotype -property_value: prefLabel "increased microtubule-based processes" xsd:string - -[Term] -id: CMPO:0000353 -name: increased monopolar cell elongation phenotype -def: "A phenotype observation of the process in which a cell increases in size due to polarized growth from one end of a cell." [] -subset: cmpo -synonym: "increased polar cell elongation" EXACT [] -is_a: CMPO:0000035 ! cell growth phenotype -is_a: CMPO:0000189 ! cellular development phenotype -property_value: prefLabel "increased monopolar cell elongation" xsd:string - -[Term] -id: CMPO:0000354 -name: decreased monopolar cell elongation phenotype -def: "A phenotype observation of the process in which a cell decreases in size due to polarized growth from one end of a cell." [] -subset: cmpo -synonym: "decreased polar cell elongation" EXACT [] -is_a: CMPO:0000035 ! cell growth phenotype -is_a: CMPO:0000189 ! cellular development phenotype -property_value: prefLabel "decreased monopolar cell elongation" xsd:string - -[Term] -id: CMPO:0000355 -name: mild actin-mediated cell contraction phenotype -def: "A phenotype of a cell contraction caused by an actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in mild contraction of all or part of the cell body." [] -subset: cmpo -is_a: CMPO:0000243 ! actin-mediated cell contraction phenotype -property_value: prefLabel "mild actin-mediated cell contraction" xsd:string - -[Term] -id: CMPO:0000356 -name: cell component localization phenotype -def: "A phenotype where any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location is observed" [] -subset: cmpo -synonym: "cell component localization" EXACT [] -is_a: CMPO:0000007 ! cell process phenotype -property_value: prefLabel "cell component localisation" xsd:string - -[Term] -id: CMPO:0000357 -name: polylobed nuclear phenotype -def: "A phenotype observation where the shape of the nucleus resembles a many-lobed berry, such as a raspberry." [] -subset: cmpo -synonym: "acinus nuclear phenotype" EXACT [] -is_a: CMPO:0000027 ! nucleus shape phenotype - -[Term] -id: CMPO:0000358 -name: increased rate of DNA amplification -def: "A phenotype of a cell where the rate of DNA amplification is increased" [] -subset: cmpo -is_a: CMPO:0000037 ! metabolic process phenotype -property_value: prefLabel "increased rate of DNA amplification" xsd:string - -[Term] -id: CMPO:0000359 -name: increased amount of DNA -def: "A phenotype observation where a cell has an increased amount of DNA" [] -subset: cmpo -is_a: CMPO:0000042 ! increased cell component number phenotype -is_a: CMPO:0000176 ! cell DNA phenotype -property_value: prefLabel "increased amount of DNA" xsd:string - -[Term] -id: CMPO:0000360 -name: centriole replication phenotype -def: "A phenotype of a cell in which the biological process resulting in a doubling of the number of centrioles in the cell is affected" [] -subset: cmpo -synonym: "centriole duplication phenotype" EXACT [] -is_a: CMPO:0000029 ! cell cycle phenotype -property_value: IAO:0000119 pmid:18620859 xsd:string -property_value: prefLabel "centriole replication" xsd:string - -[Term] -id: CMPO:0000361 -name: increased centriole replication phenotype -def: "A phenotype of a cell in which the biological process resulting in a the number of centrioles is increased" [] -subset: cmpo -synonym: "centriole amplification phenotype" EXACT [] -is_a: CMPO:0000351 ! increased microtubule-based processes phenotype -is_a: CMPO:0000360 ! centriole replication phenotype -property_value: prefLabel "increased centriole replication" xsd:string - -[Term] -id: CMPO:0000362 -name: decreased centriole replication phenotype -def: "A phenotype of a cell in which the biological process resulting in a the number of centrioles is decreased" [] -subset: cmpo -synonym: "centriole underduplication phenotype" EXACT [] -is_a: CMPO:0000360 ! centriole replication phenotype -property_value: prefLabel "decreased centriole replication" xsd:string - -[Term] -id: CMPO:0000363 -name: protein localization to cellular component phenotype -subset: cmpo -is_a: CMPO:0000356 ! cell component localization phenotype - -[Term] -id: CMPO:0000364 -name: s-shaped cell phenotype -def: "A phenotype observation at the level of the cell shape where the cell is in a shape that consists of two curves in opposite directions." [] -subset: cmpo -synonym: "kinked cell" EXACT [] -synonym: "kinky cell" EXACT [] -synonym: "sigmoid cell" EXACT [] -synonym: "z-shaped cell" EXACT [] -xref: FYPO:0002760 -is_a: CMPO:0000005 ! cell morphology phenotype -is_a: CMPO:0000011 ! cell component shape phenotype -property_value: IAO:0000119 "PMID: 25373780" xsd:string -property_value: prefLabel "S-shaped cell" xsd:string - -[Term] -id: CMPO:0000367 -name: stubby cell phenotype -def: "A phenotype observation at the level of the cell shape where the shape is stubby. The cell diameter is larger than normal and the cell length is shorter than normal." [] -subset: cmpo -synonym: "wide cell" BROAD [] -xref: FYPO:0002106 -is_a: CMPO:0000005 ! cell morphology phenotype -is_a: CMPO:0000011 ! cell component shape phenotype -property_value: IAO:0000119 "PMID: 25373780" xsd:string -property_value: prefLabel "Stubby cell" xsd:string - -[Term] -id: CMPO:0000368 -name: microtubule cytoskeleton morphology phenotype -def: "A phenotype observation at the level of the microtubule cytoskeleton relating to the components shape, size or structure" [] -subset: cmpo -is_a: CMPO:0000020 ! cytoskeletal phenotype -is_a: CMPO:0000303 ! cell component morphology phenotype -property_value: prefLabel "microtubule cytoskeleton morphology" xsd:string - -[Term] -id: CMPO:0000369 -name: microtubule cytoskeleton morphology during mitotic interphase -def: "A physical cellular phenotype in interphase of the mitotic cell cycle where the the size, shape, or structure of the microtubule cytoskeleton is observed." [] -subset: cmpo -xref: FYPO:0003625 -is_a: CMPO:0000368 ! microtubule cytoskeleton morphology phenotype -is_a: CMPO:0000385 ! mitotic interphase phenotype -property_value: IAO:0000119 "PMID: 25373780 " xsd:string -property_value: prefLabel "microtubule cytoskeleton morphology during mitotic interphase" xsd:string - -[Term] -id: CMPO:0000370 -name: elongated cytoplasmic microtubules phenotype -def: "A physical cellular phenotype which cells form cytoplasmic microtubules that are longer than normal." [] -subset: cmpo -synonym: "elongated cytoplasmic microtubules" EXACT [] -synonym: "long cytoplasmic microtubules" EXACT [] -xref: FYPO:0000233 -is_a: CMPO:0000011 ! cell component shape phenotype -is_a: CMPO:0000373 ! microtubule morphology phenotype -property_value: IAO:0000119 "PMID: 25373780" xsd:string -property_value: prefLabel "elongated cytoplasmic microtubules" xsd:string - -[Term] -id: CMPO:0000371 -name: shortened cytoplasmic microtubules phenotype -def: "A physical cellular phenotype which cells form cytoplasmic microtubules that are shorter than normal." [] -subset: cmpo -synonym: "shortened cytoplasmic microtubules" EXACT [] -xref: FYPO:0002401 -is_a: CMPO:0000011 ! cell component shape phenotype -is_a: CMPO:0000373 ! microtubule morphology phenotype -property_value: IAO:0000119 "PMID: 25373780" xsd:string -property_value: prefLabel "elongated cytoplasmic microtubules" xsd:string - -[Term] -id: CMPO:0000372 -name: increased number of microtubule bundle phenotype -def: "A phenotype observation at the level of microtubule bundle where the components number has increased. " [] -subset: cmpo -synonym: "extra microtubule bundles" EXACT [] -synonym: "increased level of MT bundles" EXACT [] -synonym: "increased microtubule bundling" EXACT [] -synonym: "more microtubule bundles" EXACT [] -xref: FYPO:0003595 -is_a: CMPO:0000042 ! increased cell component number phenotype -property_value: IAO:0000119 "PMID: 25373780 " xsd:string -property_value: prefLabel "increased number of microtubule bundle" xsd:string - -[Term] -id: CMPO:0000373 -name: microtubule morphology phenotype -def: "A phenotype observation at the level of the microtubule relating to the components shape, size or structure" [] -subset: cmpo -is_a: CMPO:0000020 ! cytoskeletal phenotype -is_a: CMPO:0000303 ! cell component morphology phenotype -property_value: IAO:0000119 "PMID: 25373780" xsd:string -property_value: prefLabel "microtubule morphology" xsd:string - -[Term] -id: CMPO:0000374 -name: microtubule morphology during interphase phenotype -def: "A phenotype observation at the level of the microtubule relating to the components shape, size or structure observed in mitotic interphase." [] -subset: cmpo -is_a: CMPO:0000373 ! microtubule morphology phenotype -is_a: CMPO:0000385 ! mitotic interphase phenotype -property_value: IAO:0000119 "PMID: 25373780" xsd:string -property_value: prefLabel "microtubule morphology during interphase" xsd:string - -[Term] -id: CMPO:0000375 -name: more cells with interphase microtubule phenotype -def: "An increased number of interphase microtubule phenotype in population." [] -subset: cmpo -is_a: CMPO:0000051 ! increased cell numbers -property_value: IAO:0000119 "PMID: 25373780" xsd:string -property_value: prefLabel "more cells with interphase microtubule" xsd:string - -[Term] -id: CMPO:0000376 -name: microtubule spindle morphology phenotype -def: "A phenotype observation at the level of the microtubule spindle relating to the components shape, size or structure" [] -subset: cmpo -is_a: CMPO:0000373 ! microtubule morphology phenotype -property_value: IAO:0000119 "PMID: 25373780" xsd:string -property_value: prefLabel "microtubule spindle morphology" xsd:string - -[Term] -id: CMPO:0000377 -name: microtubule spindle morphology during metaphase phenotype -def: "A phenotype observation at the level of the microtubule spindle relating to the components shape, size or structure observed during metaphase." [] -subset: cmpo -is_a: CMPO:0000090 ! cell cycle phase phenotype -is_a: CMPO:0000376 ! microtubule spindle morphology phenotype -property_value: IAO:0000119 "PMID: 25373780" xsd:string -property_value: prefLabel "microtubule spindle morphology during metaphase" xsd:string - -[Term] -id: CMPO:0000378 -name: more cells with metaphase microtubule spindles phenotype -def: "An increased number of metaphase microtubule spindles in population." [] -subset: cmpo -synonym: "SP increased" EXACT [] -is_a: CMPO:0000051 ! increased cell numbers -property_value: IAO:0000119 "PMID: 25373780" xsd:string -property_value: prefLabel "more cells with metaphase microtubule spindles" xsd:string - -[Term] -id: CMPO:0000379 -name: linear microtubule morphology phenotype -def: "A phenotype observation at the level of the microtubule where the microtuble are narrow, with the two opposite margins parallel." [] -subset: cmpo -is_a: CMPO:0000376 ! microtubule spindle morphology phenotype -property_value: IAO:0000119 "PMID: 25373780" xsd:string -property_value: prefLabel "linear microtubule morphology" xsd:string - -[Term] -id: CMPO:0000380 -name: cell component organisation phenotype -def: "A phenotype obesrvation relating to the orgnaistation of cellular componets in the cell." [] -subset: cmpo -is_a: CMPO:0000005 ! cell morphology phenotype -is_a: CMPO:0000012 ! cell component structure phenotype -property_value: prefLabel "cell component organisation" xsd:string - -[Term] -id: CMPO:0000381 -name: microtubule organisation phenotype -def: "A phenotype observation relating to the organisation of cellular components in the cell." [] -subset: cmpo -is_a: CMPO:0000380 ! cell component organisation phenotype -property_value: prefLabel "cell component organisation" xsd:string - -[Term] -id: CMPO:0000382 -name: microtubule array phenotype -def: "A phenotype observation relating to the organisation of microtubules in the cell, where the microtubules are organized into an array." [] -subset: cmpo -is_a: CMPO:0000381 ! microtubule organisation phenotype -property_value: IAO:0000119 "PMID: 25373780" xsd:string -property_value: prefLabel "microtubule array" xsd:string - -[Term] -id: CMPO:0000383 -name: more cells with interphase microtubule arrays phenotype -def: "An increased number of interphase microtubule array phenotype in population." [] -subset: cmpo -synonym: "IP increased" EXACT [] -is_a: CMPO:0000163 ! cell population phenotype by morphology -is_a: CMPO:0000375 ! more cells with interphase microtubule phenotype -property_value: IAO:0000119 "PMID: 25373780" xsd:string -property_value: prefLabel "more cells with interphase microtubule arrays" xsd:string - -[Term] -id: CMPO:0000384 -name: interphase phenotype -def: "A phenotype observation at the level of interphase of the cell cycle" [] -subset: cmpo -is_a: CMPO:0000090 ! cell cycle phase phenotype -property_value: prefLabel "interphase phenotype" xsd:string - -[Term] -id: CMPO:0000385 -name: mitotic interphase phenotype -def: "A phenotype observation at the level of interphase of the cell cycle" [] -subset: cmpo -is_a: CMPO:0000194 ! mitotic process phenotype -is_a: CMPO:0000384 ! interphase phenotype -property_value: prefLabel "mitotic interphase phenotype" xsd:string - -[Term] -id: CMPO:0000386 -name: anaphase phenotype -def: "A phenotype observation at the level of anaphase of the cell cycle" [] -subset: cmpo -is_a: CMPO:0000090 ! cell cycle phase phenotype -property_value: prefLabel "anaphase phenotype" xsd:string - -[Term] -id: CMPO:0000387 -name: fewer cells with metaphase microtubule spindles phenotype -def: "A decreased number of metaphase microtubule spindles in population." [] -subset: cmpo -synonym: "SP reduced" EXACT [] -is_a: CMPO:0000052 ! decreased cell numbers -property_value: IAO:0000119 "PMID: 25373780" xsd:string -property_value: prefLabel "fewer cells with metaphase microtubule spindles" xsd:string - -[Term] -id: CMPO:0000388 -name: fewer cells with interphase microtubule arrays phenotype -def: "A decreased number of interphase microtubule array phenotypes in population." [] -subset: cmpo -synonym: "IP reduced" EXACT [] -is_a: CMPO:0000052 ! decreased cell numbers -is_a: CMPO:0000163 ! cell population phenotype by morphology -property_value: IAO:0000119 "PMID: 25373780" xsd:string -property_value: prefLabel "fewer cells with interphase microtubule arrays" xsd:string - -[Term] -id: CMPO:0000390 -name: protein localized in golgi phenotype -def: "A phenotype observation in which a protein is observed to be localized within the Golgi apparatus." [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -subset: cmpo -synonym: "protein localised in Golgi" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -synonym: "protein localised in Golgi apparatus" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -synonym: "protein localized to Golgi" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -synonym: "protein localized to Golgi apparatus" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -is_a: CMPO:0000363 ! protein localization to cellular component phenotype -property_value: IAO:0000119 "PMID: 23509072" xsd:string {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} - -[Term] -id: CMPO:0000391 -name: protein localized in bud neck phenotype -def: "A phenotype observation in which a protein is observed to be localized within a cellular bud neck." [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -subset: cmpo -synonym: "protein localised in bud neck" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -synonym: "protein localized in cellular bud neck" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -synonym: "protein localized to bud neck" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -is_a: CMPO:0000356 ! cell component localization phenotype -property_value: IAO:0000119 "PMID: 23509072" xsd:string {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} - -[Term] -id: CMPO:0000392 -name: protein localized in cell periphery phenotype -def: "A phenotype observation in which a protein is observed to be localized within the cell periphery." [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -subset: cmpo -synonym: "protein localised in cell periphery" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -synonym: "protein localized to cell periphery" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -is_a: CMPO:0000356 ! cell component localization phenotype -property_value: IAO:0000119 "PMID: 23509072" xsd:string {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} - -[Term] -id: CMPO:0000393 -name: protein localized in cytosol phenotype -def: "A phenotype observation in which a protein is observed to be localized within the cytosol." [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -subset: cmpo -synonym: "protein localised in cytosol" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -synonym: "protein localized to cytosol" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -is_a: CMPO:0000356 ! cell component localization phenotype -property_value: IAO:0000119 "PMID: 23509072" xsd:string {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} - -[Term] -id: CMPO:0000394 -name: protein localized in endoplasmic reticulum phenotype -def: "A phenotype observation in which a protein is observed to be localized within the endoplasmic reticulum." [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -subset: cmpo -synonym: "protein localised in endoplasmic reticulum" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -synonym: "protein localized to endoplasmic reticulum" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -is_a: CMPO:0000363 ! protein localization to cellular component phenotype -property_value: IAO:0000119 "PMID: 23509072" xsd:string {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} - -[Term] -id: CMPO:0000395 -name: protein localized in mitochondrion phenotype -def: "A phenotype observation in which a protein is observed to be localized within a mitochondrion." [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -subset: cmpo -synonym: "protein localised in mitochondria" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -synonym: "protein localised in mitochondrion" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -synonym: "protein localized to mitochonria" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -synonym: "protein localized to mitochonrion" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -is_a: CMPO:0000363 ! protein localization to cellular component phenotype -property_value: IAO:0000119 "PMID: 23509072" xsd:string {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} - -[Term] -id: CMPO:0000396 -name: protein localized in nuclear periphery phenotype -def: "A phenotype observation in which a protein is observed to be localized within the nuclear periphery." [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -subset: cmpo -synonym: "protein localised in nuclear periphery" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -synonym: "protein localized to nuclear periphery" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -is_a: CMPO:0000398 ! protein localized in nucleus phenotype -property_value: IAO:0000119 "PMID: 23509072" xsd:string {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} - -[Term] -id: CMPO:0000397 -name: protein localized in nucleolus phenotype -def: "A phenotype observation in which a protein is observed to be localized within the nucleolus." [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -subset: cmpo -synonym: "protein localised in nucleolus" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -synonym: "protein localized to nucleolus" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -is_a: CMPO:0000398 ! protein localized in nucleus phenotype -property_value: IAO:0000119 "PMID: 23509072" xsd:string {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} - -[Term] -id: CMPO:0000398 -name: protein localized in nucleus phenotype -def: "A phenotype observation in which a protein is observed to be localized within the nucleus." [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -subset: cmpo -synonym: "protein localised in nucleus" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -synonym: "protein localized to nucleus" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -is_a: CMPO:0000363 ! protein localization to cellular component phenotype -property_value: IAO:0000119 "PMID: 23509072" xsd:string {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} - -[Term] -id: CMPO:0000399 -name: protein localized in peroxisome phenotype -def: "A phenotype observation in which a protein is observed to be localized within a peroxisome." [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -subset: cmpo -synonym: "protein localised in peroxisome" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -synonym: "protein localized to peroxisome" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -is_a: CMPO:0000363 ! protein localization to cellular component phenotype -property_value: IAO:0000119 "PMID: 23509072" xsd:string {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} - -[Term] -id: CMPO:0000400 -name: protein localized in punctate foci phenotype -def: "A phenotype observation in which a protein is observed to be localized within punctate foci" [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -subset: cmpo -synonym: "protein localised in punctate foci" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -synonym: "protein localized to punctate foci" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -is_a: CMPO:0000356 ! cell component localization phenotype -property_value: IAO:0000119 "PMID: 23509072" xsd:string {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} - -[Term] -id: CMPO:0000401 -name: protein localized in vacuole phenotype -def: "A phenotype observation in which a protein is observed to be localized within a vacuole." [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -subset: cmpo -synonym: "protein localised in vacuole" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -synonym: "protein localized to vacuole" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -is_a: CMPO:0000363 ! protein localization to cellular component phenotype -property_value: IAO:0000119 "PMID: 23509072" xsd:string {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} - -[Term] -id: CMPO:0000402 -name: protein localized in vacuolar membrane phenotype -def: "A phenotype observation in which a protein is observed to be localized within a vacuolar membrane." [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -subset: cmpo -synonym: "protein localised in vacuolar membrane" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -synonym: "protein localized to vacuolar membrane" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -is_a: CMPO:0000032 ! cell membrane organisation phenotype -is_a: CMPO:0000401 ! protein localized in vacuole phenotype -property_value: IAO:0000119 "PMID: 23509072" xsd:string {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} - -[Term] -id: CMPO:0000403 -name: protein localized to nuclear body -def: "A phenotype observation in which a protein is observed to be localized within the nuclear body." [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -subset: cmpo -synonym: "protein localised in nuclear body" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -synonym: "protein localized to nuclear body" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -is_a: CMPO:0000445 ! protein localized in nucleoplasm phenotype - -[Term] -id: CMPO:0000404 -name: protein localized in Cajal body phenotype -def: "A phenotype observation in which a protein is observed to be localized within a Cajal body." [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -subset: cmpo -synonym: "protein localised in Cajal body phenotype" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -is_a: CMPO:0000403 ! protein localized to nuclear body -property_value: IAO:0000119 "PubMed ID:24127217" xsd:string {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} - -[Term] -id: CMPO:0000405 -name: protein localized in nuclear speckle phenotype -def: "A phenotype observation in which a protein is observed to be localized within a nuclear speckle." [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -subset: cmpo -synonym: "protein localised in nuclear speckle phenotype" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -is_a: CMPO:0000403 ! protein localized to nuclear body -property_value: IAO:0000119 "PubMed ID:24127217" xsd:string {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} - -[Term] -id: CMPO:0000406 -name: protein localized in paraspeckle phenotype -def: "A phenotype observation in which a protein is observed to be localized within a paraspeckle." [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -subset: cmpo -synonym: "protein localised in paraspeckle phenotype" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -is_a: CMPO:0000403 ! protein localized to nuclear body -property_value: IAO:0000119 "PubMed ID:24127217" xsd:string {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} - -[Term] -id: CMPO:0000407 -name: protein localized in PML body phenotype -def: "A phenotype observation in which a protein is observed to be localized within a PML body." [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -subset: cmpo -synonym: "protein localised in PML body phenotype" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -synonym: "protein localised in Promyelocytic Leukemia nuclear body phenotype" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -synonym: "protein localized in Promyelocytic Leukemia nuclear body phenotype" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -is_a: CMPO:0000403 ! protein localized to nuclear body -property_value: IAO:0000119 "PubMed ID:24127217" xsd:string {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} - -[Term] -id: CMPO:0000408 -name: protein localized in polycomb body phenotype -def: "A phenotype observation in which a protein is observed to be localized within a polycomb body." [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -subset: cmpo -synonym: "protein localised in PcG body phenotype" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -synonym: "protein localized in PcG body phenotype" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -synonym: "protein localized in polycomb body phenotype" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -is_a: CMPO:0000403 ! protein localized to nuclear body -property_value: IAO:0000119 "PubMed ID:24127217" xsd:string {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} - -[Term] -id: CMPO:0000410 -name: fewer cells with G1 phase microtubule arrays phenotype -def: "A decreased number of post-anaphase or G1 phase microtubule arrays in population phenotype" [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -subset: cmpo -synonym: "fewer cells with post-anaphase microtubule arrays" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -synonym: "PAA decreased" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -is_a: CMPO:0000057 ! fewer cells in G1 -is_a: CMPO:0000163 ! cell population phenotype by morphology -property_value: IAO:0000119 "PMID: 25373780" xsd:string {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} - -[Term] -id: CMPO:0000411 -name: fewer cells with S phase microtubule arrays phenotype -def: "A decreased number of post-mitotic interphase or S phase microtubule arrays in population phenotype" [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -subset: cmpo -synonym: "fewer cells with post-mitotic interphase microtubule arrays" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -synonym: "IP2 decreased" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -is_a: CMPO:0000059 ! fewer cells in S -is_a: CMPO:0000163 ! cell population phenotype by morphology -property_value: IAO:0000119 "PMID: 25373780" xsd:string {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} - -[Term] -id: CMPO:0000412 -name: more cells with G1 phase microtubule arrays phenotype -def: "An increased number of post-anaphase or G1 phase microtubule arrays in population phenotype" [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -subset: cmpo -synonym: "more cells with post-anaphase microtubule arrays" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -synonym: "PAA increased" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -is_a: CMPO:0000055 ! more cells in G1 -is_a: CMPO:0000163 ! cell population phenotype by morphology -property_value: IAO:0000119 "PMID: 25373780" xsd:string {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} - -[Term] -id: CMPO:0000413 -name: more cells with S phase microtubule arrays phenotype -def: "An increased number of post-mitotic interphase or S phase microtubule arrays in population phenotype" [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -subset: cmpo -synonym: "IP2 increased" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -synonym: "more cells with post-mitotic interphase microtubule arrays" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -is_a: CMPO:0000053 ! more cells in S -is_a: CMPO:0000163 ! cell population phenotype by morphology -property_value: IAO:0000119 "PMID: 25373780" xsd:string {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} - -[Term] -id: CMPO:0000414 -name: cell response to stress phenotype -def: "A phenotype observation of respone to stress process within a cell. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [] -subset: cmpo -is_a: CMPO:0000007 ! cell process phenotype -property_value: prefLabel "cell response to stress" xsd:string - -[Term] -id: CMPO:0000415 -name: cell response to DNA damage phenotype -def: "A phenotype observation of a process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [] -subset: cmpo -synonym: "DNA damage" EXACT [] -is_a: CMPO:0000414 ! cell response to stress phenotype -property_value: prefLabel "cell response to DNA damage" xsd:string - -[Term] -id: CMPO:0000416 -name: fewer aggregated cells in population phenotype -def: "The population has a decreased number of cells forming cell-cell aggregates." [] -subset: cmpo -synonym: "defective cell-cell aggregation" EXACT [] -is_a: CMPO:0000052 ! decreased cell numbers -property_value: IAO:0000119 PMID:24446484 xsd:string -property_value: prefLabel "fewer aggregated cells in population" xsd:string - -[Term] -id: CMPO:0000417 -name: lack of protein in cell component localization phenotype -def: "A phenotype observation in which a protein is absent or decreased from the expected localisation of protein localisation process" [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -comment: example 'the smt3allR mutant does not show localization at the bud neck' -subset: cmpo -synonym: "protein absent from localisation to cellular component" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -is_a: CMPO:0000356 ! cell component localization phenotype -property_value: IAO:0000119 "PMID: 23547032" xsd:string {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} - -[Term] -id: CMPO:0000419 -name: response to stimulus phenotype -def: "A phenotype observation at the level of a response to stimulus process" [] -subset: cmpo -is_a: CMPO:0000007 ! cell process phenotype - -[Term] -id: CMPO:0000420 -name: response to chemical phenotype -def: "A phenotype observation at the level of a response to stimulus process" [] -subset: cmpo -is_a: CMPO:0000419 ! response to stimulus phenotype - -[Term] -id: CMPO:0000421 -name: cellular response to chemical stimulus phenotype -def: "A phenotype observation at the level of a response to stimulus process" [] -subset: cmpo -is_a: CMPO:0000420 ! response to chemical phenotype - -[Term] -id: CMPO:0000422 -name: telophase phenotype -def: "A phenotype observation at the level of telophase of the cell cycle" [] -subset: cmpo -is_a: CMPO:0000090 ! cell cycle phase phenotype -property_value: prefLabel "telophase phenotype" xsd:string - -[Term] -id: CMPO:0000423 -name: mitotic telophase phenotype -def: "A phenotype observation at the level of mitotic telophase of the cell cycle" [] -subset: cmpo -is_a: CMPO:0000194 ! mitotic process phenotype -is_a: CMPO:0000422 ! telophase phenotype -property_value: prefLabel "telophase phenotype" xsd:string - -[Term] -id: CMPO:0000424 -name: telophase arrested phenotype -def: "A phenotype of a cell where the mitotic telophase process is arrested, or ends earlier in time than expected" [] -subset: cmpo -is_a: CMPO:0000304 ! cell cycle arrested phenotype -is_a: CMPO:0000423 ! mitotic telophase phenotype -property_value: prefLabel "telophase arrested" xsd:string - -[Term] -id: CMPO:0000425 -name: protein localized in centrosome phenotype -def: "A phenotype observation in which a protein is observed to be localized within a centrosome." [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -subset: cmpo -synonym: "protein localisation in centrosome" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -synonym: "protein localised in centrosome" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -synonym: "protein localised to centrosome" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -synonym: "protein localization in centrosome" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -is_a: CMPO:0000363 ! protein localization to cellular component phenotype -property_value: IAO:0000119 PMID:23086237 xsd:string {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} - -[Term] -id: CMPO:0000426 -name: protein localized in nuclear pore phenotype -def: "A phenotype observation in which a protein is observed to be localized within a nuclear pore." [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -subset: cmpo -synonym: "protein localisation in nuclear pore" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -synonym: "protein localised in nuclear pore" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -synonym: "protein localised to nuclear pore" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -synonym: "protein localization in nuclear pore" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -is_a: CMPO:0000032 ! cell membrane organisation phenotype -is_a: CMPO:0000443 ! protein localized in nuclear membrane phenotype -property_value: IAO:0000119 PMID:23845946 xsd:string {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} - -[Term] -id: CMPO:0000427 -name: kinetochore phenotype -def: "A collection of qualities that inhere in any constituent part of the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [] -subset: cmpo -is_a: CMPO:0000150 ! organelle phenotype -property_value: prefLabel "kinetochore phenotype" xsd:string - -[Term] -id: CMPO:0000428 -name: fan-shaped cell phenotype -def: "A phenotype observation at the level of the cell shape where the cell is fan-shaped" [] -subset: cmpo -is_a: CMPO:0000005 ! cell morphology phenotype -is_a: CMPO:0000011 ! cell component shape phenotype -property_value: prefLabel "fan-shaped cell" xsd:string - -[Term] -id: CMPO:0000429 -name: cell polypeptide phenotype -def: "A phenotype observation at the level of the cell protein" [] -subset: cmpo -synonym: "cell protein phenotype" EXACT [] -is_a: CMPO:0000175 ! molecular component phenotype -property_value: prefLabel "cell protein phenotype" xsd:string - -[Term] -id: CMPO:0000430 -name: altered level of substance in cell -def: " A cell phenotype in which the amount of a specific substance measured in a cell differs from normal." [] -subset: cmpo -xref: FYPO:0000989 -xref: PomBase:mah -is_a: CMPO:0000258 ! single cell phenotype -property_value: prefLabel "altered level of substance in cell" xsd:string - -[Term] -id: CMPO:0000431 -name: altered level of polypetide in cell -def: " A cell phenotype in which the amount of polypetide measured in a cell differs from normal." [] -subset: cmpo -is_a: CMPO:0000429 ! cell polypeptide phenotype -is_a: CMPO:0000430 ! altered level of substance in cell -property_value: prefLabel "altered level of polypeptide in cell" xsd:string - -[Term] -id: CMPO:0000432 -name: altered level of polypetide in cell nucleus -def: " A cell phenotype in which the amount of polypetide measured in a cell nucleus differs from normal." [] -subset: cmpo -synonym: "altered level of protein in cell nucleus" EXACT [] -is_a: CMPO:0000024 ! nuclear phenotype -is_a: CMPO:0000431 ! altered level of polypetide in cell -property_value: prefLabel "altered level of substance in cell nucleus" xsd:string - -[Term] -id: CMPO:0000433 -name: increased level of polypetide in cell nucleus -def: " A cell phenotype in which the amount of polypetide measured in a cell nucleus increases from normal." [] -subset: cmpo -synonym: "increased level of protein in cell nucleus" EXACT [] -is_a: CMPO:0000432 ! altered level of polypetide in cell nucleus -property_value: prefLabel "incressed level of polypetide in cell nucleus" xsd:string - -[Term] -id: CMPO:0000434 -name: decreased level of polypetide in cell nucleus -def: " A cell phenotype in which the amount of polypetide measured in a cell nucleus descreases from normal." [] -subset: cmpo -synonym: "decreased level of protein in cell nucleus" EXACT [] -is_a: CMPO:0000432 ! altered level of polypetide in cell nucleus -property_value: prefLabel "descreased level of polypetide in cell nucleus" xsd:string - -[Term] -id: CMPO:0000435 -name: negative regulation of protein import into nucleus phenotype -def: "A phenotype observation where any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus." [] -subset: cmpo -is_a: CMPO:0000334 ! regulation of process phenotype -property_value: prefLabel "regulation of process phenotype" xsd:string - -[Term] -id: CMPO:0000436 -name: positive regulation of protein import into nucleus phenotype -def: "A phenotype observation where any process that starts or increases the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus." [] -subset: cmpo -is_a: CMPO:0000334 ! regulation of process phenotype -property_value: prefLabel "positive regulation of protein import into nucleus" xsd:string - -[Term] -id: CMPO:0000437 -name: abnormal mitotic cell cycle phase phenotype -def: "A phenotype where the mitotic cell cycle phase is abnormal" [] -subset: cmpo -is_a: CMPO:0000090 ! cell cycle phase phenotype -is_a: CMPO:0000194 ! mitotic process phenotype -property_value: prefLabel "abnormal mitotic cell cycle phase" xsd:string - -[Term] -id: CMPO:0000438 -name: abnormal microtubule cytoskeleton morphology during mitotic interphase -def: "A physical cellular phenotype in interphase of the mitotic cell cycle where the the size, shape, or structure of the microtubule cytoskeleton is abnormal." [] -subset: cmpo -xref: FYPO:0003625 -is_a: CMPO:0000369 ! microtubule cytoskeleton morphology during mitotic interphase -property_value: IAO:0000119 "PMID: 25373780 " xsd:string -property_value: prefLabel "abnormal microtubule cytoskeleton morphology during mitotic interphase" xsd:string - -[Term] -id: CMPO:0000439 -name: absence of protein localized in bud neck phenotype -def: "A phenotype observation in which a protein is not localized within a cellular bud neck." [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -subset: cmpo -is_a: CMPO:0000315 ! absence of cell process phenotype -is_a: CMPO:0000356 ! cell component localization phenotype - -[Term] -id: CMPO:0000440 -name: protein localized in actin filament phenotype -def: "A phenotype observation in which a protein is observed to be localized within an actin filament." [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -subset: cmpo -synonym: "protein localised in actin filament phenotype" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -is_a: CMPO:0000363 ! protein localization to cellular component phenotype -property_value: IAO:0000119 "PubMed: 22361696" xsd:string {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} - -[Term] -id: CMPO:0000441 -name: protein localized in intermediate filament phenotype -def: "A phenotype observation in which a protein is observed to be localized within an intermediate filament." [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -subset: cmpo -synonym: "protein localised in intermediate filament phenotype" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -is_a: CMPO:0000363 ! protein localization to cellular component phenotype -property_value: IAO:0000119 "PubMed: 22361696" xsd:string {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} - -[Term] -id: CMPO:0000442 -name: protein localized in microtubule phenotype -def: "A phenotype observation in which a protein is observed to be localized within a microtubule." [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -subset: cmpo -synonym: "protein localised in microtubule phenotype" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -is_a: CMPO:0000363 ! protein localization to cellular component phenotype -property_value: IAO:0000119 "PubMed: 22361696" xsd:string {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} - -[Term] -id: CMPO:0000443 -name: protein localized in nuclear membrane phenotype -def: "A phenotype observation in which a protein is observed to be localized the nuclear membrane." [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -subset: cmpo -synonym: "protein localised in nuclear envelope phenotype" EXACT [] -synonym: "protein localised in nuclear membrane phenotype" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -is_a: CMPO:0000398 ! protein localized in nucleus phenotype -property_value: IAO:0000119 "PubMed: 22361696" xsd:string {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} - -[Term] -id: CMPO:0000444 -name: protein localized in nucleoli fibrillar center phenotype -def: "A phenotype observation in which a protein is observed to be localized within the nucleolar fibrillar center." [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -subset: cmpo -synonym: "protein localised in nucleoli fibrillar center phenotype" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -is_a: CMPO:0000397 ! protein localized in nucleolus phenotype -property_value: IAO:0000119 "PubMed: 22361696" xsd:string {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} - -[Term] -id: CMPO:0000445 -name: protein localized in nucleoplasm phenotype -def: "A phenotype observation in which a protein is observed to be localized within the nucloplasm." [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -subset: cmpo -synonym: "protein localised in nucleoplasm phenotype" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -is_a: CMPO:0000398 ! protein localized in nucleus phenotype -property_value: IAO:0000119 "PubMed: 22361696" xsd:string {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} - -[Term] -id: CMPO:0000446 -name: protein localized in plasma membrane phenotype -def: "A phenotype observation in which a protein is observed to be localized within the plasma membrane." [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -subset: cmpo -synonym: "protein localised in plasma membrane phenotype" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -is_a: CMPO:0000032 ! cell membrane organisation phenotype -is_a: CMPO:0000356 ! cell component localization phenotype -property_value: IAO:0000119 "PubMed: 22361696" xsd:string {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} - -[Term] -id: CMPO:0000447 -name: protein localized in vesicle phenotype -def: "A phenotype observation in which a protein is observed to be localized within a vesicle." [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -subset: cmpo -synonym: "protein localised in vesicle phenotype" EXACT [] {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} -is_a: CMPO:0000363 ! protein localization to cellular component phenotype -property_value: IAO:0000119 "PubMed: 22361696" xsd:string {http://www.co-ode.org/patterns#createdBy="http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern"} - -[Term] -id: CMPO:0000448 -name: cell killing phenotype -def: "A phenotype where the the cells are killing either its own cells or those of another organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions." [] -subset: cmpo -is_a: CMPO:0000007 ! cell process phenotype -property_value: prefLabel "cell killing phenotype" xsd:string - -[Term] -id: CMPO:0000449 -name: T cell mediated killing against a tumor cell phenotype -def: "A phenotype where the the cells are killing either its own cells or those of another organism. The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [] -subset: cmpo -synonym: "'T cell mediated cytotoxicity directed against tumor cell target phenotype" EXACT [] -is_a: CMPO:0000419 ! response to stimulus phenotype -is_a: CMPO:0000448 ! cell killing phenotype -property_value: prefLabel "T cell mediated killing against a tumor cell phenotype" xsd:string - -[Term] -id: CMPO:0000450 -name: more aggregated cells in population phenotype -def: "The population has an increased number of cells forming cell-cell aggregates." [] -subset: cmpo -is_a: CMPO:0000051 ! increased cell numbers -property_value: prefLabel "more aggregated cells in population phenotype" xsd:string - -[Term] -id: CMPO:0000451 -name: increased nucelar area phenotype -def: "A phenotype observation where the area of the nucelus has increased. " [] -subset: cmpo -is_a: CMPO:0000140 ! increased nucleus size phenotype -property_value: prefLabel "increased nucelar area phenotype" xsd:string - -[Term] -id: CMPO:0000452 -name: decreased nucelar area phenotype -def: "A phenotype observation where the area of the nucelus has decreased. " [] -subset: cmpo -is_a: CMPO:0000141 ! decreased nucleus size phenotype -property_value: prefLabel "decreased nucelar area phenotype" xsd:string - -[Term] -id: CMPO:0000453 -name: decreased cell size in population -def: "A population of cells where there is an increased number of small cells in the population" [] -subset: cmpo -synonym: "small cells" EXACT [] -is_a: CMPO:0000051 ! increased cell numbers -is_a: CMPO:0000163 ! cell population phenotype by morphology -property_value: prefLabel "decreased cell size in population" xsd:string - -[Typedef] -id: BFO:0000050 -name: part_of -xref: BFO:0000050 -xref: OBO_REL:part_of -property_value: RO:0001900 RO:0001901 -is_transitive: true - -[Typedef] -id: BFO:0000051 -name: has_part -subset: cmpo -property_value: RO:0001900 RO:0001901 -is_transitive: true - -[Typedef] -id: BFO:0000070 -name: towards -namespace: quality -comment: Relation binding a relational quality or disposition to the relevant type of entity. -property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl - -[Typedef] -id: RO:0000052 -name: inheres_in -subset: cmpo -property_value: RO:0001900 RO:0001901 - -[Typedef] -id: RO:0000053 -name: bearer of -property_value: RO:0001900 RO:0001901 - -[Typedef] -id: RO:0000056 -name: participates in - -[Typedef] -id: RO:0002313 -name: transports or maintains localization of - -[Typedef] -id: RO:0002339 -name: has target end location - -[Typedef] -id: decreased_in_magnitude_relative_to -name: decreased_in_magnitude_relative_to -namespace: quality -def: "q1 decreased_in_magnitude_relative_to q2 if and only if magnitude(q1) < magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale." [PATOC:CJM] -comment: This relation is used to determine the 'directionality' of relative qualities such as 'decreased strength', relative to the parent type, 'strength'. -property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl -is_transitive: true -is_a: different_in_magnitude_relative_to ! different_in_magnitude_relative_to - -[Typedef] -id: different_in_magnitude_relative_to -name: different_in_magnitude_relative_to -namespace: quality -def: "q1 different_in_magnitude_relative_to q2 if and only if magnitude(q1) NOT =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale." [PATOC:CJM] -property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl - -[Typedef] -id: directly_associated_with -name: directly_associated_with -namespace: quality -def: "q1 directly_associated_with q2 iff q1 is dependent on q2, and the magnitude of q1 increases if the magnitude of q2 is increased, or the magnitude of q1 decreases if the magnitude of q2 is decreased. The relationship is not necessarily linear." [PATOC:cjm, Wikipedia:Association_(statistics)] -comment: Example: 'Lewy bodies increased number related to dystrophic neurite increased number' (from annotation of PMID:8740227 in http://ccdb.ucsd.edu/1.0/NDPO.owl#ndpo_404). Here the increase in the number of lewy bodies is directly_associated_with the increase in the number of dystrophic neurites.\nAssociation is weaker than correlation or proportionality. These relations may be later added to PATO. -property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl -created_by: cjm -creation_date: 2009-08-26T02:50:08Z - -[Typedef] -id: ends_during -name: ends_during -namespace: external -xref: RO:0002093 -property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl - -[Typedef] -id: happens_during -name: happens_during -namespace: external -xref: RO:0002092 -property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl -is_transitive: true -is_a: ends_during ! ends_during - -[Typedef] -id: has_cross_section -name: has_cross_section -namespace: quality -def: "s3 has_cross_section s3 if and only if : there exists some 2d plane that intersects the bearer of s3, and the impression of s3 upon that plane has shape quality s2." [PATOC:CJM] -comment: Example: a spherical object has the quality of being spherical, and the spherical quality has_cross_section round. -property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl - -[Typedef] -id: has_dividend_quality -name: has_dividend_quality -namespace: quality -property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl -is_a: has_ratio_quality ! has_ratio_quality - -[Typedef] -id: has_divisor_quality -name: has_divisor_quality -namespace: quality -property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl -is_a: has_ratio_quality ! has_ratio_quality - -[Typedef] -id: has_ratio_quality -name: has_ratio_quality -namespace: quality -property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl - -[Typedef] -id: http://www.ebi.ac.uk/cmpo/CMPO_has_accuracy -name: has accuracy - -[Typedef] -id: http://www.ebi.ac.uk/cmpo/CMPO_has_qualifier -name: has qualifier - -[Typedef] -id: increased_in_magnitude_relative_to -name: increased_in_magnitude_relative_to -namespace: quality -def: "q1 increased_in_magnitude_relative_to q2 if and only if magnitude(q1) > magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale." [PATOC:CJM] -comment: This relation is used to determine the 'directionality' of relative qualities such as 'increased strength', relative to the parent type, 'strength'. -property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl -is_transitive: true -is_a: different_in_magnitude_relative_to ! different_in_magnitude_relative_to - -[Typedef] -id: inversely_associated_with -name: inversely_associated_with -namespace: quality -def: "q1 inversely_associated_with q2 iff q1 is dependent on q2, and the magnitude of q1 decreases if the magnitude of q2 is increased, or the magnitude of q1 increases if the magnitude of q2 is decreased. The relationship is not necessarily linear." [PATOC:cjm, Wikipedia:Association_(statistics)] -comment: Association is weaker than correlation or proportionality. These relations may be later added to PATO. -property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl -created_by: cjm -creation_date: 2009-08-26T02:50:24Z - -[Typedef] -id: negatively_regulates -name: negatively regulates -namespace: external -xref: RO:0002212 -property_value: IAO:0000114 IAO:0000125 -property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl -is_a: regulates ! regulates - -[Typedef] -id: occurs_in -name: occurs in -namespace: external -xref: BFO:0000066 -property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl - -[Typedef] -id: positively_regulates -name: positively regulates -namespace: external -xref: RO:0002213 -property_value: IAO:0000114 IAO:0000125 -property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl -is_a: regulates ! regulates - -[Typedef] -id: reciprocal_of -name: reciprocal_of -namespace: quality -def: "q1 reciprocal_of q2 if and only if : q1 and q2 are relational qualities and a phenotype e q1 e2 mutually implies a phenotype e2 q2 e." [PATOC:CJM] -comment: There are frequently two ways to state the same thing: we can say 'spermatocyte lacks asters' or 'asters absent from spermatocyte'. In this case the quality is 'lacking all parts of type' - it is a (relational) quality of the spermatocyte, and it is with respect to instances of 'aster'. One of the popular requirements of PATO is that it continue to support 'absent', so we need to relate statements which use this quality to the 'lacking all parts of type' quality. -property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl - -[Typedef] -id: regulates -name: regulates -namespace: external -xref: RO:0002211 -property_value: IAO:0000114 IAO:0000125 -property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl - -[Typedef] -id: similar_in_magnitude_relative_to -name: similar_in_magnitude_relative_to -namespace: quality -def: "q1 similar_in_magnitude_relative_to q2 if and only if magnitude(q1) =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale." [PATOC:CJM] -property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl - diff --git a/release/cmpo.owl b/release/cmpo.owl deleted file mode 100644 index 38b52920..00000000 --- a/release/cmpo.owl +++ /dev/null @@ -1,74649 +0,0 @@ - - - - Cellular Microscopy Phenotype Ontology - Bran Herpers - Jennifer L. Rohn - James Malone - Frauke Neff - Jean-Karim Heriche - Johan Lundin - Zvi Kam - Gabriella Rustici - cmpo - Thomas Walter - Simon Jupp - Beate Neumann - Claudia Lukas - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - definition source - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - cmpo - CMPO subset - - - - - - - - - Grouping classes that can be excluded - - - - - - - - - Term not to be used for direct annotation - - - - - - - - - Term not to be used for direct manual annotation - - - - - - - - - Aspergillus GO slim - - - - - - - - - Candida GO slim - - - - - - - - - ChEMBL protein targets summary - - - - - - - - - Generic GO slim - - - - - - - - - GOA and proteome slim - - - - - - - - - Metagenomics GO slim - - - - - - - - - PIR GO slim - - - - - - - - - Plant GO slim - - - - - - - - - Fission yeast GO slim - - - - - - - - - synapse GO slim - - - - - - - - - Viral GO slim - - - - - - - - - Yeast GO slim - - - - - - - - - Prokaryotic GO subset - - - - - - - - - Catalytic activity terms in need of attention - - - - - - - - - Systematic synonym - - - - - - - - - - Terms created by TermGenie that do not follow a template and require additional vetting by editors - - - - - - - - - Viral overhaul terms - - - - - - - - - - - - - - - subset_property - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - has_alternative_id - - - - - - - - has_broad_synonym - - - - - - - - database_cross_reference - - - - - - - - has_exact_synonym - - - - - - - - has_narrow_synonym - - - - - - - - has_obo_namespace - - - - - - - - has_related_synonym - - - - - - - - has_scope - - - - - - - - - - - - - - in_subset - - - - - - - - shorthand - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - part_of - BFO:0000050 - OBO_REL:part_of - part_of - - - - - - - - - - has_part - - - - - - - - - - occurs in - BFO:0000066 - external - occurs_in - occurs_in - - - - - - - - - towards - Relation binding a relational quality or disposition to the relevant type of entity. - quality - towards - - - - - - - - - inheres_in - - - - - - - - - - bearer of - - - - - - - - - participates in - - - - - - - - located in - - - - - - - - - - happens_during - RO:0002092 - external - happens_during - happens_during - - - - - - - - - - ends_during - RO:0002093 - ends_during - ends_during - external - - - - - - - - - regulates - RO:0002211 - external - regulates - regulates - - - - - - - - - - negatively regulates - RO:0002212 - external - negatively_regulates - negatively_regulates - - - - - - - - - - - positively regulates - RO:0002213 - external - positively_regulates - positively_regulates - - - - - - - - - - - transports or maintains localization of - - - - - - - - has target end location - - - - - - - - - decreased_in_magnitude_relative_to - This relation is used to determine the 'directionality' of relative qualities such as 'decreased strength', relative to the parent type, 'strength'. - decreased_in_magnitude_relative_to - q1 decreased_in_magnitude_relative_to q2 if and only if magnitude(q1) < magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale. - quality - - - - - - - PATOC:CJM - q1 decreased_in_magnitude_relative_to q2 if and only if magnitude(q1) < magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale. - - - - - - - - - - different_in_magnitude_relative_to - different_in_magnitude_relative_to - q1 different_in_magnitude_relative_to q2 if and only if magnitude(q1) NOT =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale. - quality - - - - - - PATOC:CJM - q1 different_in_magnitude_relative_to q2 if and only if magnitude(q1) NOT =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale. - - - - - - - - - - directly_associated_with - 2009-08-26T02:50:08Z - Example: 'Lewy bodies increased number related to dystrophic neurite increased number' (from annotation of PMID:8740227 in http://ccdb.ucsd.edu/1.0/NDPO.owl#ndpo_404). Here the increase in the number of lewy bodies is directly_associated_with the increase in the number of dystrophic neurites. -Association is weaker than correlation or proportionality. These relations may be later added to PATO. - cjm - directly_associated_with - q1 directly_associated_with q2 iff q1 is dependent on q2, and the magnitude of q1 increases if the magnitude of q2 is increased, or the magnitude of q1 decreases if the magnitude of q2 is decreased. The relationship is not necessarily linear. - quality - - - - - - PATOC:cjm - Wikipedia:Association_(statistics) - q1 directly_associated_with q2 iff q1 is dependent on q2, and the magnitude of q1 increases if the magnitude of q2 is increased, or the magnitude of q1 decreases if the magnitude of q2 is decreased. The relationship is not necessarily linear. - - - - - - - - - - has_cross_section - Example: a spherical object has the quality of being spherical, and the spherical quality has_cross_section round. - has_cross_section - quality - s3 has_cross_section s3 if and only if : there exists some 2d plane that intersects the bearer of s3, and the impression of s3 upon that plane has shape quality s2. - - - - PATOC:CJM - s3 has_cross_section s3 if and only if : there exists some 2d plane that intersects the bearer of s3, and the impression of s3 upon that plane has shape quality s2. - - - - - - - - - - has_dividend_quality - has_dividend_quality - quality - - - - - - - - - - - has_divisor_quality - has_divisor_quality - quality - - - - - - - - - - - has_ratio_quality - has_ratio_quality - quality - - - - - - - - - - - increased_in_magnitude_relative_to - This relation is used to determine the 'directionality' of relative qualities such as 'increased strength', relative to the parent type, 'strength'. - increased_in_magnitude_relative_to - q1 increased_in_magnitude_relative_to q2 if and only if magnitude(q1) > magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale. - quality - - - - - - - PATOC:CJM - q1 increased_in_magnitude_relative_to q2 if and only if magnitude(q1) > magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale. - - - - - - - - - - inversely_associated_with - 2009-08-26T02:50:24Z - Association is weaker than correlation or proportionality. These relations may be later added to PATO. - cjm - inversely_associated_with - q1 inversely_associated_with q2 iff q1 is dependent on q2, and the magnitude of q1 decreases if the magnitude of q2 is increased, or the magnitude of q1 increases if the magnitude of q2 is decreased. The relationship is not necessarily linear. - quality - - - - - - PATOC:cjm - Wikipedia:Association_(statistics) - q1 inversely_associated_with q2 iff q1 is dependent on q2, and the magnitude of q1 decreases if the magnitude of q2 is increased, or the magnitude of q1 increases if the magnitude of q2 is decreased. The relationship is not necessarily linear. - - - - - - - - - - reciprocal_of - There are frequently two ways to state the same thing: we can say 'spermatocyte lacks asters' or 'asters absent from spermatocyte'. In this case the quality is 'lacking all parts of type' - it is a (relational) quality of the spermatocyte, and it is with respect to instances of 'aster'. One of the popular requirements of PATO is that it continue to support 'absent', so we need to relate statements which use this quality to the 'lacking all parts of type' quality. - q1 reciprocal_of q2 if and only if : q1 and q2 are relational qualities and a phenotype e q1 e2 mutually implies a phenotype e2 q2 e. - quality - reciprocal_of - - - - PATOC:CJM - q1 reciprocal_of q2 if and only if : q1 and q2 are relational qualities and a phenotype e q1 e2 mutually implies a phenotype e2 q2 e. - - - - - - - - - - similar_in_magnitude_relative_to - q1 similar_in_magnitude_relative_to q2 if and only if magnitude(q1) =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale. - quality - similar_in_magnitude_relative_to - - - - - - PATOC:CJM - q1 similar_in_magnitude_relative_to q2 if and only if magnitude(q1) =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale. - - - - - - - - - - has accuracy - - - - - - - - has qualifier - - - - - - - - - - - - - polypeptide - - protein - - - - - - - - deoxyribonucleic acid - - - - - - - - - molecular entity - - - - - - - - nucleic acid - - - - - - - - - macromolecule - - - - - - - - - cell in vitro - - A cell that is maintained or propagated in a controlled artificial environment for use in an investigation. - - - - - - - - mitotic sister chromatid segregation - - - - - - - - - - - - - - - - - - - - - - - - - - GO:0000070 - GO:0016359 - The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets. - biological_process - mitotic chromosome segregation - mitotic sister-chromatid adhesion release - - - - GOC:ai - GOC:jl - The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets. - - - - - - - - - - mitotic G1 phase - - - - - - - - - G1 phase of mitotic cell cycle - GO:0000080 - Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). - Reactome:REACT_101162 - Reactome:REACT_1590 - Reactome:REACT_29795 - Reactome:REACT_34060 - Reactome:REACT_78665 - Reactome:REACT_78866 - Reactome:REACT_83686 - Reactome:REACT_91654 - Reactome:REACT_93384 - Reactome:REACT_93574 - The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by mitosis and the beginning of DNA synthesis. - biological_process - - - - - G1 Phase, Gallus gallus - Reactome:REACT_78665 - - - - - G1 Phase, Sus scrofa - Reactome:REACT_78866 - - - - - G1 Phase, Danio rerio - Reactome:REACT_83686 - - - - - G1 Phase, Taeniopygia guttata - Reactome:REACT_29795 - - - - - G1 Phase, Homo sapiens - Reactome:REACT_1590 - - - - - G1 Phase, Xenopus tropicalis - Reactome:REACT_93574 - - - - - G1 Phase, Canis familiaris - Reactome:REACT_34060 - - - - - G1 Phase, Rattus norvegicus - Reactome:REACT_93384 - - - - - G1 Phase, Bos taurus - Reactome:REACT_101162 - - - - - GOC:mtg_cell_cycle - The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by mitosis and the beginning of DNA synthesis. - - - - - G1 Phase, Mus musculus - Reactome:REACT_91654 - - - - - - - - - - mitotic S phase - - - - - - - - - GO:0000084 - Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). - Reactome:REACT_105829 - Reactome:REACT_108550 - Reactome:REACT_110039 - Reactome:REACT_28988 - Reactome:REACT_32013 - Reactome:REACT_34043 - Reactome:REACT_78838 - Reactome:REACT_78845 - Reactome:REACT_81914 - Reactome:REACT_82813 - Reactome:REACT_85811 - Reactome:REACT_89318 - Reactome:REACT_899 - Reactome:REACT_92500 - Reactome:REACT_92759 - Reactome:REACT_95174 - Reactome:REACT_96081 - Reactome:REACT_97603 - Reactome:REACT_99645 - S phase of mitotic cell cycle - S-phase of mitotic cell cycle - The cell cycle phase, following G1, during which DNA synthesis takes place as part of a mitotic cell cycle. - biological_process - - - - - S Phase, Drosophila melanogaster - Reactome:REACT_89318 - - - - - GOC:mtg_cell_cycle - The cell cycle phase, following G1, during which DNA synthesis takes place as part of a mitotic cell cycle. - - - - - S Phase, Mus musculus - Reactome:REACT_92500 - - - - - S Phase, Mycobacterium tuberculosis - Reactome:REACT_32013 - - - - - S Phase, Danio rerio - Reactome:REACT_97603 - - - - - S Phase, Taeniopygia guttata - Reactome:REACT_28988 - - - - - S Phase, Canis familiaris - Reactome:REACT_92759 - - - - - S Phase, Schizosaccharomyces pombe - Reactome:REACT_110039 - - - - - S Phase, Bos taurus - Reactome:REACT_99645 - - - - - S Phase, Rattus norvegicus - Reactome:REACT_108550 - - - - - S Phase, Oryza sativa - Reactome:REACT_34043 - - - - - S Phase, Sus scrofa - Reactome:REACT_85811 - - - - - S Phase, Gallus gallus - Reactome:REACT_95174 - - - - - S Phase, Homo sapiens - Reactome:REACT_899 - - - - - S Phase, Arabidopsis thaliana - Reactome:REACT_82813 - - - - - S Phase, Dictyostelium discoideum - Reactome:REACT_96081 - - - - - S Phase, Xenopus tropicalis - Reactome:REACT_78845 - - - - - S Phase, Saccharomyces cerevisiae - Reactome:REACT_81914 - - - - - S Phase, Plasmodium falciparum - Reactome:REACT_78838 - - - - - S Phase, Caenorhabditis elegans - Reactome:REACT_105829 - - - - - - - - - - mitotic G2 phase - - - - - - - - - G2 phase of mitotic cell cycle - GO:0000085 - Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). - Reactome:REACT_105223 - Reactome:REACT_105307 - Reactome:REACT_106415 - Reactome:REACT_106836 - Reactome:REACT_1915 - Reactome:REACT_28975 - Reactome:REACT_85928 - Reactome:REACT_96332 - The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by mitosis. - biological_process - - - - - G2 Phase, Danio rerio - Reactome:REACT_96332 - - - - - G2 Phase, Sus scrofa - Reactome:REACT_85928 - - - - - G2 Phase, Canis familiaris - Reactome:REACT_105307 - - - - - G2 Phase, Bos taurus - Reactome:REACT_106836 - - - - - G2 Phase, Xenopus tropicalis - Reactome:REACT_106415 - - - - - G2 Phase, Homo sapiens - Reactome:REACT_1915 - - - - - G2 Phase, Mus musculus - Reactome:REACT_105223 - - - - - GOC:mtg_cell_cycle - The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by mitosis. - - - - - G2 Phase, Rattus norvegicus - Reactome:REACT_28975 - - - - - - - - - - G2/M transition of mitotic cell cycle - - - - - - - - - - - - - - - - - - - - GO:0000086 - Reactome:REACT_100942 - Reactome:REACT_103766 - Reactome:REACT_107882 - Reactome:REACT_114616 - Reactome:REACT_2203 - Reactome:REACT_28929 - Reactome:REACT_30388 - Reactome:REACT_34062 - Reactome:REACT_77778 - Reactome:REACT_83880 - Reactome:REACT_87036 - Reactome:REACT_87230 - Reactome:REACT_87807 - Reactome:REACT_88018 - Reactome:REACT_88369 - Reactome:REACT_92702 - The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex. - biological_process - mitotic G2/M transition - - - - G2/M Transition, Xenopus tropicalis - Reactome:REACT_28929 - - - - - G2/M Transition, Bos taurus - Reactome:REACT_92702 - - - - - G2/M Transition, Sus scrofa - Reactome:REACT_107882 - - - - - G2/M Transition, Schizosaccharomyces pombe - Reactome:REACT_103766 - - - - - GOC:mtg_cell_cycle - The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex. - - - - - G2/M Transition, Dictyostelium discoideum - Reactome:REACT_87807 - - - - - G2/M Transition, Danio rerio - Reactome:REACT_100942 - - - - - G2/M Transition, Caenorhabditis elegans - Reactome:REACT_88018 - - - - - G2/M Transition, Drosophila melanogaster - Reactome:REACT_83880 - - - - - G2/M Transition, Homo sapiens - Reactome:REACT_2203 - - - - - G2/M Transition, Canis familiaris - Reactome:REACT_87230 - - - - - G2/M Transition, Arabidopsis thaliana - Reactome:REACT_114616 - - - - - G2/M Transition, Gallus gallus - Reactome:REACT_30388 - - - - - G2/M Transition, Rattus norvegicus - Reactome:REACT_88369 - - - - - G2/M Transition, Taeniopygia guttata - Reactome:REACT_77778 - - - - - G2/M Transition, Saccharomyces cerevisiae - Reactome:REACT_87036 - - - - - G2/M Transition, Mus musculus - Reactome:REACT_34062 - - - - - - - - - - mitotic M phase - - - - - - - - - - - - - - - - - - - - A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a mitotic cell cycle. - GO:0000087 - M phase of mitotic cell cycle - M-phase of mitotic cell cycle - Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). - Reactome:REACT_105412 - Reactome:REACT_107095 - Reactome:REACT_109059 - Reactome:REACT_29488 - Reactome:REACT_33490 - Reactome:REACT_82055 - Reactome:REACT_87132 - Reactome:REACT_88263 - Reactome:REACT_910 - Reactome:REACT_92998 - Reactome:REACT_93131 - Reactome:REACT_93566 - Reactome:REACT_93720 - Reactome:REACT_94536 - biological_process - - - - - M Phase, Homo sapiens - Reactome:REACT_910 - - - - - M Phase, Saccharomyces cerevisiae - Reactome:REACT_109059 - - - - - M Phase, Schizosaccharomyces pombe - Reactome:REACT_93131 - - - - - M Phase, Gallus gallus - Reactome:REACT_93566 - - - - - M Phase, Bos taurus - Reactome:REACT_87132 - - - - - M Phase, Rattus norvegicus - Reactome:REACT_82055 - - - - - M Phase, Dictyostelium discoideum - Reactome:REACT_107095 - - - - - M Phase, Drosophila melanogaster - Reactome:REACT_93720 - - - - - A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a mitotic cell cycle. - GOC:mtg_cell_cycle - - - - - M Phase, Canis familiaris - Reactome:REACT_29488 - - - - - M Phase, Taeniopygia guttata - Reactome:REACT_94536 - - - - - M Phase, Danio rerio - Reactome:REACT_92998 - - - - - M Phase, Caenorhabditis elegans - Reactome:REACT_33490 - - - - - M Phase, Mus musculus - Reactome:REACT_105412 - - - - - M Phase, Xenopus tropicalis - Reactome:REACT_88263 - - - - - - - - - - mitotic prophase - - - - - - - - - GO:0000088 - Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). - Reactome:REACT_100605 - Reactome:REACT_102122 - Reactome:REACT_105127 - Reactome:REACT_106058 - Reactome:REACT_28443 - Reactome:REACT_28607 - Reactome:REACT_32677 - Reactome:REACT_765 - Reactome:REACT_79474 - Reactome:REACT_80300 - Reactome:REACT_83888 - Reactome:REACT_90347 - Reactome:REACT_90481 - The cell cycle phase which is the first stage of M phase of mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell. - biological_process - - - - - Mitotic Prophase, Canis familiaris - Reactome:REACT_90347 - - - - - Mitotic Prophase, Danio rerio - Reactome:REACT_105127 - - - - - Mitotic Prophase, Saccharomyces cerevisiae - Reactome:REACT_100605 - - - - - Mitotic Prophase, Schizosaccharomyces pombe - Reactome:REACT_90481 - - - - - Mitotic Prophase, Gallus gallus - Reactome:REACT_80300 - - - - - Mitotic Prophase, Rattus norvegicus - Reactome:REACT_28607 - - - - - Mitotic Prophase, Drosophila melanogaster - Reactome:REACT_106058 - - - - - GOC:mtg_cell_cycle - The cell cycle phase which is the first stage of M phase of mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell. - - - - - Mitotic Prophase, Dictyostelium discoideum - Reactome:REACT_83888 - - - - - Mitotic Prophase, Xenopus tropicalis - Reactome:REACT_32677 - - - - - Mitotic Prophase, Caenorhabditis elegans - Reactome:REACT_79474 - - - - - Mitotic Prophase, Homo sapiens - Reactome:REACT_765 - - - - - Mitotic Prophase, Taeniopygia guttata - Reactome:REACT_28443 - - - - - Mitotic Prophase, Mus musculus - Reactome:REACT_102122 - - - - - - - - - - mitotic metaphase - - - - - - - - - GO:0000089 - Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). - Reactome:REACT_434 - The cell cycle phase, following prophase, during which chromosomes become aligned on the equatorial plate of the cell as part of a mitotic cell cycle. - biological_process - - - - - Mitotic Metaphase, Homo sapiens - Reactome:REACT_434 - - - - - GOC:mtg_cell_cycle - The cell cycle phase, following prophase, during which chromosomes become aligned on the equatorial plate of the cell as part of a mitotic cell cycle. - - - - - - - - - - mitotic telophase - - - - - - - - - GO:0000093 - Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). - The cell cycle phase which follows anaphase during M phase of mitosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts. - biological_process - - - - - GOC:mtg_cell_cycle - The cell cycle phase which follows anaphase during M phase of mitosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts. - - - - - - - - - - microtubule cytoskeleton organization - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. - GO:0000226 - biological_process - microtubule cytoskeleton organisation - microtubule cytoskeleton organization and biogenesis - microtubule dynamics - - - - GOC:mah - microtubule cytoskeleton organisation - - - - - GOC:mah - microtubule cytoskeleton organization and biogenesis - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. - GOC:mah - - - - - GOC:dph - GOC:tb - microtubule dynamics - - - - - - - - - - mitotic prometaphase - - - - - - - - GO:0000236 - Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). - Reactome:REACT_102823 - Reactome:REACT_104270 - Reactome:REACT_105082 - Reactome:REACT_114704 - Reactome:REACT_118069 - Reactome:REACT_118526 - Reactome:REACT_118539 - Reactome:REACT_31336 - Reactome:REACT_31385 - Reactome:REACT_682 - Reactome:REACT_79351 - Reactome:REACT_83126 - Reactome:REACT_98905 - Reactome:REACT_99376 - The cell cycle phase in higher eukaryotes which follows mitotic prophase and during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region. Kinetochores mature on each centromere and attach to some of the spindle microtubules. Kinetochore microtubules begin the process of aligning chromosomes in one plane halfway between the poles. - biological_process - - - - - Mitotic Prometaphase, Gallus gallus - Reactome:REACT_118069 - - - - - Mitotic Prometaphase, Dictyostelium discoideum - Reactome:REACT_105082 - - - - - Mitotic Prometaphase, Saccharomyces cerevisiae - Reactome:REACT_118526 - - - - - GOC:mtg_cell_cycle - The cell cycle phase in higher eukaryotes which follows mitotic prophase and during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region. Kinetochores mature on each centromere and attach to some of the spindle microtubules. Kinetochore microtubules begin the process of aligning chromosomes in one plane halfway between the poles. - - - - - Mitotic Prometaphase, Caenorhabditis elegans - Reactome:REACT_31385 - - - - - Mitotic Prometaphase, Mus musculus - Reactome:REACT_102823 - - - - - Mitotic Prometaphase, Xenopus tropicalis - Reactome:REACT_98905 - - - - - Mitotic Prometaphase, Canis familiaris - Reactome:REACT_99376 - - - - - Mitotic Prometaphase, Rattus norvegicus - Reactome:REACT_79351 - - - - - Mitotic Prometaphase, Bos taurus - Reactome:REACT_104270 - - - - - Mitotic Prometaphase, Danio rerio - Reactome:REACT_31336 - - - - - Mitotic Prometaphase, Taeniopygia guttata - Reactome:REACT_118539 - - - - - Mitotic Prometaphase, Homo sapiens - Reactome:REACT_682 - - - - - Mitotic Prometaphase, Drosophila melanogaster - Reactome:REACT_83126 - - - - - Mitotic Prometaphase, Schizosaccharomyces pombe - Reactome:REACT_114704 - - - - - - - - - - mitotic cell cycle - - - - - - - - - - - - - - - - - - - GO:0000278 - Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. - Reactome:REACT_100451 - Reactome:REACT_104035 - Reactome:REACT_104195 - Reactome:REACT_105856 - Reactome:REACT_108233 - Reactome:REACT_152 - Reactome:REACT_28464 - Reactome:REACT_28953 - Reactome:REACT_33388 - Reactome:REACT_53493 - Reactome:REACT_79085 - Reactome:REACT_84794 - Reactome:REACT_85137 - Reactome:REACT_85950 - Reactome:REACT_90332 - Reactome:REACT_90846 - Reactome:REACT_96281 - Reactome:REACT_97744 - Reactome:REACT_98208 - biological_process - - - - - Cell Cycle, Mitotic, Rattus norvegicus - Reactome:REACT_33388 - - - - - Cell Cycle, Mitotic, Taeniopygia guttata - Reactome:REACT_100451 - - - - - GOC:mah - ISBN:0815316194 - Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. - Reactome:69278 - - - - - Cell Cycle, Mitotic, Saccharomyces cerevisiae - Reactome:REACT_108233 - - - - - Cell Cycle, Mitotic, Mycobacterium tuberculosis - Reactome:REACT_98208 - - - - - Cell Cycle, Mitotic, Caenorhabditis elegans - Reactome:REACT_84794 - - - - - Cell Cycle, Mitotic, Danio rerio - Reactome:REACT_105856 - - - - - Cell Cycle, Mitotic, Sus scrofa - Reactome:REACT_104035 - - - - - Cell Cycle, Mitotic, Gallus gallus - Reactome:REACT_85137 - - - - - Cell Cycle, Mitotic, Plasmodium falciparum - Reactome:REACT_53493 - - - - - Cell Cycle, Mitotic, Arabidopsis thaliana - Reactome:REACT_85950 - - - - - Cell Cycle, Mitotic, Canis familiaris - Reactome:REACT_104195 - - - - - Cell Cycle, Mitotic, Mus musculus - Reactome:REACT_90332 - - - - - Cell Cycle, Mitotic, Bos taurus - Reactome:REACT_28953 - - - - - Cell Cycle, Mitotic, Drosophila melanogaster - Reactome:REACT_96281 - - - - - Cell Cycle, Mitotic, Xenopus tropicalis - Reactome:REACT_28464 - - - - - Cell Cycle, Mitotic, Oryza sativa - Reactome:REACT_90846 - - - - - Cell Cycle, Mitotic, Schizosaccharomyces pombe - Reactome:REACT_79085 - - - - - Cell Cycle, Mitotic, Homo sapiens - Reactome:REACT_152 - - - - - Cell Cycle, Mitotic, Dictyostelium discoideum - Reactome:REACT_97744 - - - - - - - - - - M phase - - A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase. - GO:0000279 - M-phase - Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). - Wikipedia:M_phase - biological_process - - - - - A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase. - GOC:mtg_cell_cycle - - - - - - - - - - nuclear division - - GO:0000280 - The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei. - biological_process - karyokinesis - - - - - GOC:mah - The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei. - - - - - - - - - - DNA catabolic process, endonucleolytic - - - - - - - - - DNA breakdown, endonucleolytic - DNA degradation, endonucleolytic - GO:0000737 - The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides. - biological_process - endonucleolytic DNA catabolism - endonucleolytic degradation of DNA - - - - - GOC:elh - GOC:mah - The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides. - - - - - - - - - - chromosome, centromeric region - - GO:0000775 - GO:0097521 - Note that this term can be used in place of the obsolete cellular component term 'centromere ; GO:0005698'. - The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. - cellular_component - centromere - centromere complex - chromosome, centric region - chromosome, pericentric region - - - - GOC:cjm - GOC:elh - GOC:kmv - GOC:pr - The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. - - - - - - - - - - kinetochore - - - - - - - - - - A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. - GO:0000776 - GO:0005699 - Note that the kinetochore overlaps the centromeric DNA, but centromeric DNA is not part of the kinetochore. - Wikipedia:Kinetochore - cellular_component - - - - - A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. - GOC:elh - - - - - - - - - - sister chromatid segregation - - - - GO:0000819 - The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets. - biological_process - - - - GOC:ai - GOC:elh - The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets. - - - - - - - - - - cell morphogenesis - - GO:0000902 - GO:0007148 - GO:0045790 - GO:0045791 - The developmental process in which the size or shape of a cell is generated and organized. - biological_process - cellular morphogenesis - - - - - - - - - GOC:clt - GOC:dph - GOC:go_curators - GOC:tb - The developmental process in which the size or shape of a cell is generated and organized. - - - - - - - - - - cell morphogenesis involved in differentiation - - - - - - - - - - - - - - - - - - - GO:0000904 - The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. - biological_process - - - - GOC:go_curators - The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. - - - - - - - - - - cytokinesis - - - - - - - - - - - - - - GO:0000910 - GO:0007104 - GO:0016288 - GO:0033205 - Note that when annotating eukaryotic species, mitotic or meiotic cytokinesis should always be specified for manual annotation and for prokaryotic species use 'FtsZ-dependent cytokinesis ; GO:0043093' or Cdv-dependent cytokinesis ; GO:0061639. Also, note that cytokinesis does not necessarily result in physical separation and detachment of the two daughter cells from each other. - Reactome:REACT_101918 - Reactome:REACT_108805 - Reactome:REACT_1932 - Reactome:REACT_30667 - Reactome:REACT_32636 - Reactome:REACT_78494 - Reactome:REACT_84722 - Reactome:REACT_87726 - Reactome:REACT_92849 - Reactome:REACT_93374 - Reactome:REACT_94382 - Reactome:REACT_98952 - Reactome:REACT_99118 - The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells. - Wikipedia:Cytokinesis - biological_process - cell cycle cytokinesis - cytokinesis involved in cell cycle - - - - - - - - - Mitotic Telophase /Cytokinesis, Xenopus tropicalis - Reactome:REACT_87726 - - - - - Mitotic Telophase /Cytokinesis, Gallus gallus - Reactome:REACT_84722 - - - - - Mitotic Telophase /Cytokinesis, Mus musculus - Reactome:REACT_101918 - - - - - GOC:dph - GOC:tb - cytokinesis involved in cell cycle - - - - - Mitotic Telophase /Cytokinesis, Drosophila melanogaster - Reactome:REACT_94382 - - - - - Mitotic Telophase /Cytokinesis, Canis familiaris - Reactome:REACT_93374 - - - - - Mitotic Telophase /Cytokinesis, Rattus norvegicus - Reactome:REACT_98952 - - - - - Mitotic Telophase /Cytokinesis, Dictyostelium discoideum - Reactome:REACT_108805 - - - - - Mitotic Telophase /Cytokinesis, Caenorhabditis elegans - Reactome:REACT_99118 - - - - - Mitotic Telophase /Cytokinesis, Schizosaccharomyces pombe - Reactome:REACT_30667 - - - - - Mitotic Telophase /Cytokinesis, Bos taurus - Reactome:REACT_32636 - - - - - Mitotic Telophase /Cytokinesis, Homo sapiens - Reactome:REACT_1932 - - - - - GOC:mtg_cell_cycle - The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells. - - - - - Mitotic Telophase /Cytokinesis, Danio rerio - Reactome:REACT_78494 - - - - - Mitotic Telophase /Cytokinesis, Taeniopygia guttata - Reactome:REACT_92849 - - - - - - - - - - regulatory region DNA binding - - - 2010-08-10T10:56:24Z - GO:0000975 - Interacting selectively and non-covalently with a DNA region that regulates a DNA-based process. Such processes include transcription, DNA replication, and DNA repair. - kchris - molecular_function - - - - GOC:txnOH - Interacting selectively and non-covalently with a DNA region that regulates a DNA-based process. Such processes include transcription, DNA replication, and DNA repair. - - - - - - - - - - transcription regulatory region sequence-specific DNA binding - - - 2010-08-10T11:00:02Z - GO:0000976 - Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. - The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding". - kchris - molecular_function - - - - GOC:txnOH - Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. - - - - - - - - - - regulatory region nucleic acid binding - - 2010-10-21T04:08:56Z - GO:0001067 - Interacting selectively and non-covalently with a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair. - kchris - molecular_function - - - - GOC:txnOH - Interacting selectively and non-covalently with a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair. - - - - - - - - - - nucleic acid binding transcription factor activity - - - - - - - - - - - - - - 2010-10-21T04:37:54Z - GO:0001071 - Interacting selectively and non-covalently with a DNA or RNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. - Note that this term is in the subset of terms that should not be used for direct gene product annotation. This term does not provide specificity with respect to the type of nucleic acid binding, e.g. RNA or DNA. Please use a child term that provides that specificity or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - kchris - molecular_function - transcription factor activity - - - - - - - - - GOC:txnOH - Interacting selectively and non-covalently with a DNA or RNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. - - - - - - - - - - stress fiber - - - A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber. - GO:0001725 - actin cable - cellular_component - stress fibre - - - - A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber. - PMID:16651381 - - - - - GOC:mah - actin cable - - - - - - - - - - cell killing - - - Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions. - GO:0001906 - biological_process - necrosis - - - - - - Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions. - GOC:add - - - - - - - - - - leukocyte mediated cytotoxicity - - - GO:0001909 - The directed killing of a target cell by a leukocyte. - This term was improved by GO_REF:0000022. It was moved. Note that this term and its children describe contact-dependent killing of target cells by lymphocytes and myeloid cells of the immune system. - biological_process - immune cell mediated cell death - immune cell mediated cell killing - immune cell mediated cytotoxicity - leucocyte mediated cytotoxicity - - - - GOC:add - GOC:mtg_15nov05 - GO_REF:0000022 - ISBN:0781735149 - PMID:11911826 - The directed killing of a target cell by a leukocyte. - - - - - - - - - - T cell mediated cytotoxicity - - - - GO:0001913 - Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in the induction of apoptosis in the target cell. Note that both CD4 and CD8 positive T cells can mediate apoptosis of target cells, independently of their definition as 'helper' T cells or not. - T cell mediated apoptosis - T cell mediated cell death - T cell mediated cell killing - T cell mediated cytolysis - T lymphocyte mediated cytotoxicity - T-cell mediated apoptosis - T-cell mediated cell death - T-cell mediated cell killing - T-cell mediated cytotoxicity - T-lymphocyte mediated cytotoxicity - The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. - biological_process - - - - GOC:add - GOC:pr - ISBN:0781735149 - PMID:11911826 - The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. - - - - - - - - - - podosome - - - - - - - - - - An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm. - GO:0002102 - Note that podosomes can be distinguished from other F-actin-rich structures or from other matrix contacts. For example, focal adhesions and focal contacts do not display a core structure of F-actin. Unlike focal adhesions, podosome assembly does not require de novo protein synthesis. However, most of the podosome ring components are found in focal adhesions and other cell-matrix contacts. Podosomes are typically found in cells that cross tissue boundaries, recruited to the leading edge of migrating cells, and are often sites of extracellular matrix degradation. - Wikipedia:Podosome - cellular_component - - - - An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm. - PMID:12837608 - PMID:15890982 - - - - - - - - - - adaptive immune response - - An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory). - GO:0002250 - This term was added by GO_REF:0000022. - Wikipedia:Adaptive_immune_system - acquired immune response - biological_process - - - - An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory). - GOC:add - GOC:mtg_15nov05 - GO_REF:0000022 - ISBN:0781735149 - - - - - ISBN:068340007X - acquired immune response - - - - - - - - - - immune effector process - - Any process of the immune system that can potentially contribute to an immune response. - GO:0002252 - This term was added by GO_REF:0000022. - biological_process - - - - Any process of the immune system that can potentially contribute to an immune response. - GOC:add - GOC:mtg_15nov05 - GO_REF:0000022 - ISBN:0781735149 - - - - - - - - - - response to tumor cell - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell. - GO:0002347 - biological_process - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell. - GOC:add - ISBN:0781735149 - PMID:16730260 - - - - - - - - - - immune system process - - - Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats. - GO:0002376 - Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501). This term was added by GO_REF:0000022. - Wikipedia:Immune_system - biological_process - - - - - - - - Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats. - GOC:add - GOC:mtg_15nov05 - GO_REF:0000022 - - - - - - - - - - immune response to tumor cell - - - An immune system process that functions in the response of an organism to a tumor cell. - GO:0002418 - biological_process - - - - An immune system process that functions in the response of an organism to a tumor cell. - GOC:add - ISBN:0781735149 - PMID:16730260 - - - - - - - - - - T cell mediated cytotoxicity directed against tumor cell target - - - GO:0002419 - Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell. - T lymphocyte mediated cytotoxicity directed against tumor cell target - T-cell mediated cytotoxicity directed against tumor cell target - T-lymphocyte mediated cytotoxicity directed against tumor cell target - The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. - biological_process - - - - GOC:add - ISBN:0781735149 - PMID:16730260 - The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. - - - - - - - - - - T cell mediated immune response to tumor cell - - - An immune response mediated by a T cell triggered in response to the presence of a tumor cell. - GO:0002424 - Note that this term includes tolerogenic responses to tumor cells mediated by responding T cells. - biological_process - - - - An immune response mediated by a T cell triggered in response to the presence of a tumor cell. - GOC:add - ISBN:0781735149 - PMID:16730260 - - - - - - - - - - leukocyte mediated immunity - - Any process involved in the carrying out of an immune response by a leukocyte. - GO:0002443 - GO:0019723 - GO:0042087 - This term was added by GO_REF:0000022. - biological_process - cell-mediated immune response - cellular immune response - immune cell effector process - immune cell mediated immunity - leucocyte immune effector process - leucocyte mediated immunity - leukocyte immune effector process - - - - Any process involved in the carrying out of an immune response by a leukocyte. - GOC:add - GOC:mtg_15nov05 - GO_REF:0000022 - ISBN:0781735149 - - - - - - - - - - lymphocyte mediated immunity - - Any process involved in the carrying out of an immune response by a lymphocyte. - GO:0002449 - This term was added by GO_REF:0000022. - biological_process - cell-mediated immunity - cellular immune response - - - - Any process involved in the carrying out of an immune response by a lymphocyte. - GOC:add - GOC:mtg_15nov05 - GO_REF:0000022 - ISBN:0781735149 - - - - - - - - - - T cell mediated immunity - - - Any process involved in the carrying out of an immune response by a T cell. - GO:0002456 - T lymphocyte mediated immunity - T-cell mediated immunity - T-lymphocyte mediated immunity - This term was added by GO_REF:0000022. - biological_process - cell-mediated immunity - cellular immune response - - - - Any process involved in the carrying out of an immune response by a T cell. - GOC:add - GOC:mtg_15nov05 - GO_REF:0000022 - ISBN:0781735149 - - - - - - - - - - adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains - - An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus. - GO:0002460 - biological_process - - - - An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus. - GOC:add - GOC:mtg_sensu - ISBN:0781735149 - - - - - - - - - - molecular_function - Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions. - GO:0003674 - GO:0005554 - Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. Note that when this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this. - molecular function - molecular_function - - - - - - - - - - - - - Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions. - GOC:go_curators - - - - - - - - - - nucleic acid binding - - - GO:0003676 - Interacting selectively and non-covalently with any nucleic acid. - molecular_function - - - - - - - - - GOC:jl - Interacting selectively and non-covalently with any nucleic acid. - - - - - - - - - - DNA binding - - Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). - GO:0003677 - microtubule/chromatin interaction - molecular_function - plasmid binding - - - - - - - - - - - Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). - GOC:dph - GOC:jl - GOC:tb - GOC:vw - - - - - - - - - - sequence-specific DNA binding transcription factor activity - - - - - - - - - - - - - - GO:0000130 - GO:0003700 - Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. - molecular_function - transcription factor activity - - - - - - GOC:curators - GOC:txnOH - Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. - - - - - - - - - - telomerase activity - - Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence. - EC:2.7.7.- - GO:0003720 - Reactome:REACT_104705 - Reactome:REACT_106476 - Reactome:REACT_108407 - Reactome:REACT_109443 - Reactome:REACT_113385 - Reactome:REACT_114466 - Reactome:REACT_115824 - Reactome:REACT_116122 - Reactome:REACT_28249 - Reactome:REACT_30494 - Reactome:REACT_30995 - Reactome:REACT_31549 - Reactome:REACT_33436 - Reactome:REACT_77280 - Reactome:REACT_7985 - Reactome:REACT_8019 - Reactome:REACT_80834 - Reactome:REACT_81691 - Reactome:REACT_83982 - Reactome:REACT_85286 - Reactome:REACT_86666 - Reactome:REACT_90823 - Reactome:REACT_93232 - Reactome:REACT_94534 - Reactome:REACT_94768 - Reactome:REACT_95176 - Reactome:REACT_96912 - Reactome:REACT_97770 - molecular_function - - - - Elongation of Extended Telomeric Chromosome End, Canis familiaris - Reactome:REACT_81691 - - - - - Elongation and translocation of the extended telomeric chromosome end, Gallus gallus - Reactome:REACT_115824 - - - - - Elongation of Extended Telomeric Chromosome End, Oryza sativa - Reactome:REACT_108407 - - - - - Elongation Of The Telomeric Chromosome End, Xenopus tropicalis - Reactome:REACT_113385 - - - - - Elongation of Extended Telomeric Chromosome End, Saccharomyces cerevisiae - Reactome:REACT_104705 - - - - - Elongation Of The Telomeric Chromosome End, Schizosaccharomyces pombe - Reactome:REACT_93232 - - - - - Elongation of Extended Telomeric Chromosome End, Mus musculus - Reactome:REACT_90823 - - - - - Elongation Of The Telomeric Chromosome End, Mus musculus - Reactome:REACT_80834 - - - - - Elongation of Extended Telomeric Chromosome End, Sus scrofa - Reactome:REACT_86666 - - - - - Elongation of Extended Telomeric Chromosome End, Taeniopygia guttata - Reactome:REACT_96912 - - - - - Elongation of Extended Telomeric Chromosome End, Xenopus tropicalis - Reactome:REACT_114466 - - - - - Elongation of Extended Telomeric Chromosome End, Arabidopsis thaliana - Reactome:REACT_77280 - - - - - Elongation Of The Telomeric Chromosome End, Oryza sativa - Reactome:REACT_83982 - - - - - Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence. - GOC:krc - - - - - Elongation of Extended Telomeric Chromosome End, Gallus gallus - Reactome:REACT_28249 - - - - - Elongation Of The Telomeric Chromosome End, Arabidopsis thaliana - Reactome:REACT_97770 - - - - - Elongation and translocation of the telomeric chromosome end, Gallus gallus - Reactome:REACT_116122 - - - - - Elongation Of The Telomeric Chromosome End, Homo sapiens - Reactome:REACT_8019 - - - - - Elongation Of The Telomeric Chromosome End, Sus scrofa - Reactome:REACT_30494 - - - - - Elongation Of The Telomeric Chromosome End, Gallus gallus - Reactome:REACT_95176 - - - - - Elongation Of The Telomeric Chromosome End, Bos taurus - Reactome:REACT_106476 - - - - - Elongation of Extended Telomeric Chromosome End, Schizosaccharomyces pombe - Reactome:REACT_94768 - - - - - Elongation Of The Telomeric Chromosome End, Taeniopygia guttata - Reactome:REACT_94534 - - - - - Elongation Of The Telomeric Chromosome End, Danio rerio - Reactome:REACT_109443 - - - - - Elongation of Extended Telomeric Chromosome End, Bos taurus - Reactome:REACT_85286 - - - - - Elongation Of The Telomeric Chromosome End, Saccharomyces cerevisiae - Reactome:REACT_31549 - - - - - Elongation Of The Telomeric Chromosome End, Canis familiaris - Reactome:REACT_30995 - - - - - Elongation of Extended Telomeric Chromosome End, Homo sapiens - Reactome:REACT_7985 - - - - - Elongation of Extended Telomeric Chromosome End, Danio rerio - Reactome:REACT_33436 - - - - - - - - - - catalytic activity - - - - - - - - Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. - GO:0003824 - Wikipedia:Enzyme - enzyme activity - molecular_function - - - - - - - - GOC:dph - GOC:tb - enzyme activity - - - - - Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. - ISBN:0198506732 - - - - - - - - - - RNA-directed DNA polymerase activity - - - - - - - - Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. - DNA nucleotidyltransferase (RNA-directed) activity - EC:2.7.7.49 - GO:0003964 - MetaCyc:RNA-DIRECTED-DNA-POLYMERASE-RXN - RNA revertase activity - RNA-dependent DNA polymerase activity - RNA-dependent deoxyribonucleate nucleotidyltransferase activity - RNA-directed DNA polymerase, group II intron encoded - RNA-directed DNA polymerase, transposon encoded - RNA-instructed DNA polymerase activity - RT - Reactome:REACT_9039 - Reactome:REACT_9049 - deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) activity - molecular_function - reverse transcriptase activity - revertase activity - - - - - Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. - EC:2.7.7.49 - - - - - EC:2.7.7.49 - reverse transcriptase activity - - - - - EC:2.7.7.49 - RNA-dependent deoxyribonucleate nucleotidyltransferase activity - - - - - EC:2.7.7.49 - RNA-instructed DNA polymerase activity - - - - - DNA nucleotidyltransferase (RNA-directed) activity - EC:2.7.7.49 - - - - - EC:2.7.7.49 - revertase activity - - - - - EC:2.7.7.49 - RNA revertase activity - - - - - EC:2.7.7.49 - RT - - - - - Synthesis of minus strand strong stop DNA (-sssDNA), Homo sapiens - Reactome:REACT_9039 - - - - - EC:2.7.7.49 - deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) activity - - - - - Minus strand DNA synthesis resumes, Homo sapiens - Reactome:REACT_9049 - - - - - EC:2.7.7.49 - RNA-dependent DNA polymerase activity - - - - - - - - - - nuclease activity - - - - - - - - Catalysis of the hydrolysis of ester linkages within nucleic acids. - EC:3.1.-.- - GO:0004518 - Note that 'tRNA nucleotidyltransferase activity ; GO:0009022', also known as 'ribonuclease PH', does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. - molecular_function - - - - - - - - - - Catalysis of the hydrolysis of ester linkages within nucleic acids. - ISBN:0198547684 - - - - - - - - - - endonuclease activity - - Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. - GO:0004519 - Reactome:REACT_100654 - Reactome:REACT_101397 - Reactome:REACT_103600 - Reactome:REACT_106502 - Reactome:REACT_108614 - Reactome:REACT_110731 - Reactome:REACT_112366 - Reactome:REACT_1124 - Reactome:REACT_112509 - Reactome:REACT_112615 - Reactome:REACT_112782 - Reactome:REACT_113127 - Reactome:REACT_113480 - Reactome:REACT_113819 - Reactome:REACT_114931 - Reactome:REACT_115221 - Reactome:REACT_115226 - Reactome:REACT_115382 - Reactome:REACT_115937 - Reactome:REACT_116011 - Reactome:REACT_1914 - Reactome:REACT_34610 - Reactome:REACT_6746 - Reactome:REACT_6774 - Reactome:REACT_77706 - Reactome:REACT_78624 - Reactome:REACT_79198 - Reactome:REACT_80387 - Reactome:REACT_80628 - Reactome:REACT_80681 - Reactome:REACT_80797 - Reactome:REACT_81714 - Reactome:REACT_87541 - Reactome:REACT_89800 - Reactome:REACT_90034 - Reactome:REACT_90935 - Reactome:REACT_92894 - molecular_function - - - - - 3'- incision of DNA by XPG in GG-NER, Arabidopsis thaliana - Reactome:REACT_100654 - - - - - Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. - GOC:mah - ISBN:0198547684 - - - - - 3'- incision of DNA by XPG in GG-NER, Mus musculus - Reactome:REACT_90034 - - - - - 3'- incision of DNA by XPG in GG-NER, Caenorhabditis elegans - Reactome:REACT_80387 - - - - - Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Danio rerio - Reactome:REACT_112366 - - - - - Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Gallus gallus - Reactome:REACT_113480 - - - - - 3'- incision of DNA by XPG in GG-NER, Xenopus tropicalis - Reactome:REACT_110731 - - - - - Removal of 3'-phosphate moiety from DSB ends, Homo sapiens - Reactome:REACT_6746 - - - - - Cleavage of mRNA at the 3'-end, Bos taurus - Reactome:REACT_34610 - - - - - 3'- incision of DNA by XPG in GG-NER, Sus scrofa - Reactome:REACT_90935 - - - - - 3'- incision of DNA by XPG in GG-NER, Gallus gallus - Reactome:REACT_103600 - - - - - Cleavage of mRNA at the 3'-end, Homo sapiens - Reactome:REACT_1914 - - - - - Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Rattus norvegicus - Reactome:REACT_112615 - - - - - Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Sus scrofa - Reactome:REACT_115382 - - - - - Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Mus musculus - Reactome:REACT_115221 - - - - - 3'- incision of DNA by XPG in GG-NER, Bos taurus - Reactome:REACT_80681 - - - - - Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Gallus gallus - Reactome:REACT_116011 - - - - - 3'- incision of DNA by XPG in GG-NER, Drosophila melanogaster - Reactome:REACT_92894 - - - - - Cleavage of mRNA at the 3'-end, Canis familiaris - Reactome:REACT_79198 - - - - - 3'- incision of DNA by XPG in GG-NER, Homo sapiens - Reactome:REACT_1124 - - - - - 3'- incision of DNA by XPG in GG-NER, Danio rerio - Reactome:REACT_101397 - - - - - 3'- incision of DNA by XPG in GG-NER, Saccharomyces cerevisiae - Reactome:REACT_80628 - - - - - 3'- incision of DNA by XPG in GG-NER, Taeniopygia guttata - Reactome:REACT_108614 - - - - - Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Taeniopygia guttata - Reactome:REACT_113127 - - - - - 3'- incision of DNA by XPG in GG-NER, Schizosaccharomyces pombe - Reactome:REACT_89800 - - - - - Cleavage of mRNA at the 3'-end, Arabidopsis thaliana - Reactome:REACT_112509 - - - - - Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Homo sapiens - Reactome:REACT_6774 - - - - - Cleavage of mRNA at the 3'-end, Xenopus tropicalis - Reactome:REACT_87541 - - - - - Displacement of DNA glycosylase and endonucleolytic cleavage by DNA-lyase, Gallus gallus - Reactome:REACT_115937 - - - - - 3'- incision of DNA by XPG in GG-NER, Rattus norvegicus - Reactome:REACT_106502 - - - - - Cleavage of mRNA at the 3'-end, Drosophila melanogaster - Reactome:REACT_113819 - - - - - Cleavage of mRNA at the 3'-end, Taeniopygia guttata - Reactome:REACT_77706 - - - - - Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Xenopus tropicalis - Reactome:REACT_112782 - - - - - Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Bos taurus - Reactome:REACT_115226 - - - - - Cleavage of mRNA at the 3'-end, Mus musculus - Reactome:REACT_80797 - - - - - 3'- incision of DNA by XPG in GG-NER, Canis familiaris - Reactome:REACT_78624 - - - - - 3'- incision of DNA by XPG in GG-NER, Oryza sativa - Reactome:REACT_81714 - - - - - Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Canis familiaris - Reactome:REACT_114931 - - - - - - - - - - endodeoxyribonuclease activity - - - Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks. - DNA nicking activity - GO:0004520 - Reactome:REACT_101184 - Reactome:REACT_101250 - Reactome:REACT_101987 - Reactome:REACT_103441 - Reactome:REACT_103771 - Reactome:REACT_104010 - Reactome:REACT_104673 - Reactome:REACT_104703 - Reactome:REACT_104968 - Reactome:REACT_106756 - Reactome:REACT_109040 - Reactome:REACT_109537 - Reactome:REACT_109692 - Reactome:REACT_110386 - Reactome:REACT_112122 - Reactome:REACT_112152 - Reactome:REACT_115154 - Reactome:REACT_115463 - Reactome:REACT_115479 - Reactome:REACT_1274 - Reactome:REACT_1311 - Reactome:REACT_1964 - Reactome:REACT_27164 - Reactome:REACT_27209 - Reactome:REACT_28610 - Reactome:REACT_28960 - Reactome:REACT_30718 - Reactome:REACT_31162 - Reactome:REACT_31548 - Reactome:REACT_31660 - Reactome:REACT_31823 - Reactome:REACT_32833 - Reactome:REACT_33043 - Reactome:REACT_78421 - Reactome:REACT_79265 - Reactome:REACT_80173 - Reactome:REACT_80298 - Reactome:REACT_80967 - Reactome:REACT_811 - Reactome:REACT_81197 - Reactome:REACT_82925 - Reactome:REACT_83838 - Reactome:REACT_85019 - Reactome:REACT_88339 - Reactome:REACT_90087 - Reactome:REACT_92741 - Reactome:REACT_94592 - Reactome:REACT_94820 - Reactome:REACT_95903 - Reactome:REACT_97114 - Reactome:REACT_98405 - Reactome:REACT_98417 - Reactome:REACT_99783 - endonuclease G activity - molecular_function - - - - - 5' incision leading to excision of DNA fragment with lesion in TC-NER, Canis familiaris - Reactome:REACT_82925 - - - - - 3' incision of the lesioned strand of DNA in TC-NER, Arabidopsis thaliana - Reactome:REACT_92741 - - - - - 5'-incision of DNA by ERCC1-XPF in GG-NER, Homo sapiens - Reactome:REACT_1311 - - - - - Removal of SPO11 and Resection of 5' Ends of DNA (yeast), Saccharomyces cerevisiae - Reactome:REACT_27164 - - - - - 5' incision leading to excision of DNA fragment with lesion in TC-NER, Sus scrofa - Reactome:REACT_78421 - - - - - 5' incision leading to excision of DNA fragment with lesion in TC-NER, Taeniopygia guttata - Reactome:REACT_115463 - - - - - 3' incision of the lesioned strand of DNA in TC-NER, Homo sapiens - Reactome:REACT_1274 - - - - - 3' incision of the lesioned strand of DNA in TC-NER, Sus scrofa - Reactome:REACT_109692 - - - - - 5' incision leading to excision of DNA fragment with lesion in TC-NER, Arabidopsis thaliana - Reactome:REACT_31162 - - - - - 5' incision leading to excision of DNA fragment with lesion in TC-NER, Gallus gallus - Reactome:REACT_115154 - - - - - APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Bos taurus - Reactome:REACT_98417 - - - - - 5' incision leading to excision of DNA fragment with lesion in TC-NER, Oryza sativa - Reactome:REACT_31823 - - - - - 3' incision of the lesioned strand of DNA in TC-NER, Rattus norvegicus - Reactome:REACT_28960 - - - - - 5'-incision of DNA by ERCC1-XPF in GG-NER, Rattus norvegicus - Reactome:REACT_83838 - - - - - 3' incision of the lesioned strand of DNA in TC-NER, Oryza sativa - Reactome:REACT_80967 - - - - - APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Canis familiaris - Reactome:REACT_94820 - - - - - APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Homo sapiens - Reactome:REACT_1964 - - - - - 5'-incision of DNA by ERCC1-XPF in GG-NER, Danio rerio - Reactome:REACT_101184 - - - - - APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Rattus norvegicus - Reactome:REACT_103441 - - - - - 5' incision leading to excision of DNA fragment with lesion in TC-NER, Saccharomyces cerevisiae - Reactome:REACT_98405 - - - - - 5' incision leading to excision of DNA fragment with lesion in TC-NER, Danio rerio - Reactome:REACT_90087 - - - - - APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Mus musculus - Reactome:REACT_80173 - - - - - 5' incision leading to excision of DNA fragment with lesion in TC-NER, Caenorhabditis elegans - Reactome:REACT_101250 - - - - - 3' incision of the lesioned strand of DNA in TC-NER, Drosophila melanogaster - Reactome:REACT_106756 - - - - - 3' incision of the lesioned strand of DNA in TC-NER, Dictyostelium discoideum - Reactome:REACT_30718 - - - - - APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Danio rerio - Reactome:REACT_104010 - - - - - Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks. - GOC:mah - ISBN:0198547684 - - - - - 3' incision of the lesioned strand of DNA in TC-NER, Gallus gallus - Reactome:REACT_115479 - - - - - 3' incision of the lesioned strand of DNA in TC-NER, Mus musculus - Reactome:REACT_99783 - - - - - 3' incision of the lesioned strand of DNA in TC-NER, Bos taurus - Reactome:REACT_33043 - - - - - 5' incision leading to excision of DNA fragment with lesion in TC-NER, Bos taurus - Reactome:REACT_28610 - - - - - Removal of SPO11 and Resection of 5' Ends of DNA, Homo sapiens - Reactome:REACT_27209 - - - - - 3' incision of the lesioned strand of DNA in TC-NER, Canis familiaris - Reactome:REACT_109040 - - - - - 5' incision leading to excision of DNA fragment with lesion in TC-NER, Rattus norvegicus - Reactome:REACT_88339 - - - - - APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Xenopus tropicalis - Reactome:REACT_109537 - - - - - 3' incision of the lesioned strand of DNA in TC-NER, Caenorhabditis elegans - Reactome:REACT_80298 - - - - - 5' incision leading to excision of DNA fragment with lesion in TC-NER, Dictyostelium discoideum - Reactome:REACT_79265 - - - - - 5' incision leading to excision of DNA fragment with lesion in TC-NER, Drosophila melanogaster - Reactome:REACT_94592 - - - - - APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Drosophila melanogaster - Reactome:REACT_85019 - - - - - DNA nicking activity - GOC:mah - - - - - 5'-incision of DNA by ERCC1-XPF in GG-NER, Mus musculus - Reactome:REACT_95903 - - - - - 3' incision of the lesioned strand of DNA in TC-NER, Schizosaccharomyces pombe - Reactome:REACT_31660 - - - - - APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Dictyostelium discoideum - Reactome:REACT_101987 - - - - - APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Sus scrofa - Reactome:REACT_104968 - - - - - APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Caenorhabditis elegans - Reactome:REACT_31548 - - - - - 5' incision leading to excision of DNA fragment with lesion in TC-NER, Schizosaccharomyces pombe - Reactome:REACT_104673 - - - - - 3' incision of the lesioned strand of DNA in TC-NER, Taeniopygia guttata - Reactome:REACT_112152 - - - - - 3' incision of the lesioned strand of DNA in TC-NER, Danio rerio - Reactome:REACT_110386 - - - - - APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Taeniopygia guttata - Reactome:REACT_104703 - - - - - 3' incision of the lesioned strand of DNA in TC-NER, Xenopus tropicalis - Reactome:REACT_103771 - - - - - 3' incision of the lesioned strand of DNA in TC-NER, Saccharomyces cerevisiae - Reactome:REACT_32833 - - - - - 5'-incision of DNA by ERCC1-XPF in GG-NER, Xenopus tropicalis - Reactome:REACT_112122 - - - - - 5' incision leading to excision of DNA fragment with lesion in TC-NER, Mus musculus - Reactome:REACT_81197 - - - - - 5' incision leading to excision of DNA fragment with lesion in TC-NER, Homo sapiens - Reactome:REACT_811 - - - - - 5' incision leading to excision of DNA fragment with lesion in TC-NER, Xenopus tropicalis - Reactome:REACT_97114 - - - - - - - - - - deoxyribonuclease activity - - - - - - - - Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid. - GO:0004536 - GO:0004537 - Reactome:REACT_100642 - Reactome:REACT_101208 - Reactome:REACT_110575 - Reactome:REACT_13702 - Reactome:REACT_29722 - Reactome:REACT_31853 - Reactome:REACT_90424 - Reactome:REACT_95359 - Reactome:REACT_98682 - caspase-activated deoxyribonuclease activity - molecular_function - - - - - Cleavage of DNA by DFF40, Bos taurus - Reactome:REACT_101208 - - - - - Cleavage of DNA by DFF40, Canis familiaris - Reactome:REACT_98682 - - - - - Cleavage of DNA by DFF40, Rattus norvegicus - Reactome:REACT_95359 - - - - - Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid. - GOC:mah - ISBN:0198547684 - - - - - Cleavage of DNA by DFF40, Xenopus tropicalis - Reactome:REACT_100642 - - - - - Cleavage of DNA by DFF40, Danio rerio - Reactome:REACT_29722 - - - - - Cleavage of DNA by DFF40, Homo sapiens - Reactome:REACT_13702 - - - - - Cleavage of DNA by DFF40, Gallus gallus - Reactome:REACT_90424 - - - - - Cleavage of DNA by DFF40, Sus scrofa - Reactome:REACT_110575 - - - - - Cleavage of DNA by DFF40, Taeniopygia guttata - Reactome:REACT_31853 - - - - - - - - - - binding - - GO:0005488 - Note that this term is in the subset of terms that should not be used for direct, manual gene product annotation. Please choose a more specific child term, or request a new one if no suitable term is available. For ligands that bind to signal transducing receptors, consider the molecular function term 'receptor binding ; GO:0005102' and its children. - The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. - Wikipedia:Binding_(molecular) - ligand - molecular_function - - - - - - - - GOC:ceb - GOC:mah - ISBN:0198506732 - The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. - - - - - - - - - - cellular_component - GO:0005575 - GO:0008372 - NIF_Subcellular:sao-1337158144 - NIF_Subcellular:sao1337158144 - Note that, in addition to forming the root of the cellular component ontology, this term is recommended for use for the annotation of gene products whose cellular component is unknown. Note that when this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this. - The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together. - cell or subcellular entity - cellular component - cellular_component - subcellular entity - - - - - - - - - - - - - NIF_Subcellular:nlx_subcell_100315 - subcellular entity - - - - - GOC:go_curators - NIF_Subcellular:sao-1337158144 - The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together. - - - - - - - - - - intracellular - - GO:0005622 - The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. - Wikipedia:Intracellular - cellular_component - internal to cell - nucleocytoplasm - protoplasm - protoplast - - - - - - - - - ISBN:0198506732 - The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. - - - - - GOC:mah - protoplast - - - - - GOC:mah - nucleocytoplasm - - - - - - - - - - cell - - GO:0005623 - NIF_Subcellular:sao1813327414 - The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. - Wikipedia:Cell_(biology) - cell and encapsulating structures - cellular_component - - - - - - - - GOC:go_curators - The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. - - - - - - - - - - nucleus - - A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. - GO:0005634 - NIF_Subcellular:sao1702920020 - Wikipedia:Cell_nucleus - cell nucleus - cellular_component - - - - - - - - - - - - A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. - GOC:go_curators - - - - - - - - - - nucleoplasm - - - - - - - - GO:0005654 - NIF_Subcellular:sao661522542 - That part of the nuclear content other than the chromosomes or the nucleolus. - Wikipedia:Nucleoplasm - cellular_component - - - - - - - GOC:ma - ISBN:0124325653 - That part of the nuclear content other than the chromosomes or the nucleolus. - - - - - - - - - - chromosome - - A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. - Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore. - GO:0005694 - Wikipedia:Chromosome - cellular_component - chromatid - interphase chromosome - prophase chromosome - - - - - - - - - - - - A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. - ISBN:0198547684 - - - - - - - - - - nucleolus - - - - - - - - - A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. - GO:0005730 - NIF_Subcellular:sao1820400233 - Wikipedia:Nucleolus - cellular_component - - - - - - - - - - - A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. - ISBN:0198506732 - - - - - - - - - - cytoplasm - - All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. - GO:0005737 - Wikipedia:Cytoplasm - cellular_component - - - - - - - - - - - All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. - ISBN:0198547684 - - - - - - - - - - mitochondrion - - - A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. - GO:0005739 - NIF_Subcellular:sao1860313010 - Some anaerobic or microaerophilic organisms (e.g. Entamoeba histolytica, Giardia intestinalis and several Microsporidia species) do not have mitochondria, and contain mitochondrion-related organelles (MROs) instead, called mitosomes or hydrogenosomes, very likely derived from mitochondria. To annotate gene products located in these mitochondrial relics in species such as Entamoeba histolytica, Giardia intestinalis or others, please use GO:0032047 'mitosome' or GO:0042566 'hydrogenosome'. (See PMID:24316280 for a list of species currently known to contain mitochondrion-related organelles.) - Wikipedia:Mitochondrion - cellular_component - mitochondria - - - - - - - - - - - - A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. - GOC:giardia - ISBN:0198506732 - - - - - - - - - - vacuole - - - A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. - GO:0005773 - Wikipedia:Vacuole - cellular_component - vacuolar carboxypeptidase Y - - - - - - - - - - - - - A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. - GOC:mtg_sensu - ISBN:0198506732 - - - - - - - - - - endoplasmic reticulum - - - - - - - - - ER - GO:0005783 - NIF_Subcellular:sao1036339110 - The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). - Wikipedia:Endoplasmic_reticulum - cellular_component - - - - - - - - - - - - ISBN:0198506732 - The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). - - - - - - - - - - Golgi apparatus - - - - - - - - - A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. - GO:0005794 - Golgi - Golgi complex - Golgi ribbon - NIF_Subcellular:sao451912436 - Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon. - Wikipedia:Golgi_apparatus - cellular_component - - - - - - - - - - - - A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. - ISBN:0198506732 - - - - - - - - - - spindle - - - - - - - - - GO:0005819 - The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. - Wikipedia:Spindle_apparatus - cellular_component - - - - ISBN:0198547684 - The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. - - - - - - - - - - cytosol - - GO:0005829 - NIF_Subcellular:sao101633890 - The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. - Wikipedia:Cytosol - cellular_component - - - - - - - - - GOC:hgd - GOC:jl - The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. - - - - - - - - - - cytoskeleton - - Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. - GO:0005856 - Wikipedia:Cytoskeleton - cellular_component - - - - - - - - - - - - - Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. - GOC:mah - ISBN:0198547684 - PMID:16959967 - - - - - - - - - - microtubule - - - - - - - - - Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. - GO:0005874 - NIF_Subcellular:sao1846835077 - Wikipedia:Microtubule - cellular_component - microtubuli - microtubulus - neurotubule - - - - Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. - ISBN:0879693568 - - - - - NIF_Subcellular:sao248349196 - neurotubule - - - - - - - - - - spindle microtubule - - - - - - - - - - - - - - - - - - - Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole. - GO:0005876 - cellular_component - - - - Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole. - ISBN:0815316194 - - - - - - - - - - cytoplasmic microtubule - - - - - - - - - - - - - - - - - - - - Any microtubule in the cytoplasm of a cell. - GO:0005881 - cellular_component - non-spindle-associated astral microtubule - - - - Any microtubule in the cytoplasm of a cell. - GOC:mah - - - - - - - - - - actin filament - - - - - - - - - A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane. - FMA:63850 - GO:0005884 - NIF_Subcellular:sao1588493326 - Wikipedia:Actin - cellular_component - microfilament - - - - A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane. - GOC:mah - ISBN:0198506732 - PMID:10666339 - - - - - - - - - - plasma membrane - - - - - - - - - GO:0005886 - GO:0005904 - NIF_Subcellular:sao1663586795 - The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. - Wikipedia:Cell_membrane - bacterial inner membrane - cell membrane - cellular membrane - cellular_component - cytoplasmic membrane - inner endospore membrane - juxtamembrane - plasma membrane lipid bilayer - plasmalemma - - - - - - - - - - - - GOC:mah - plasma membrane lipid bilayer - - - - - ISBN:0716731363 - The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. - - - - - NIF_Subcellular:sao6433132645 - cellular membrane - - - - - - - - - - adherens junction - - A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments. - GO:0005912 - Wikipedia:Adherens_junction - cellular_component - - - - A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments. - GOC:mah - ISBN:0198506732 - http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html - - - - - - - - - - cell-substrate adherens junction - - - An adherens junction which connects a cell to the extracellular matrix. - GO:0005924 - cellular_component - hemi-adherens junction - - - - An adherens junction which connects a cell to the extracellular matrix. - GOC:hb - - - - - - - - - - focal adhesion - - GO:0005925 - GO:0008357 - Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. - Wikipedia:Focal_adhesion - adhesion plaque - cellular_component - focal contact - hemi-adherens junction - - - - ISBN:0124325653 - ISBN:0815316208 - Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. - - - - - PMID:3332661 - adhesion plaque - - - - - - - - - - cilium - - - - - - - - - A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. - FMA:67181 - GO:0005929 - NIF_Subcellular:sao787716553 - Note that we deem cilium and microtubule-based flagellum to be equivalent. In most eukaryotic species, intracellular sub-components of the cilium, such as the ciliary base and rootlet, are located near the plasma membrane. In Diplomonads such as Giardia, instead, the same ciliary parts are located further intracellularly. - Wikipedia:Cilium - cellular_component - eukaryotic flagellum - flagellum - microtubule-based flagellum - - - - - - - A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. - GOC:cilia - GOC:kmv - GOC:vw - ISBN:0198547684 - - - - - - - - - - cell cortex - - - - - - - - GO:0005938 - The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. - Wikipedia:Cell_cortex - cell periphery - cellular_component - peripheral cytoplasm - - - - - - - GOC:mah - ISBN:0815316194 - The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. - - - - - - - - - - nucleobase-containing compound metabolic process - - - - - - Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. - GO:0006139 - GO:0055134 - biological_process - cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolic process - cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolism - nucleobase, nucleoside and nucleotide metabolic process - nucleobase, nucleoside, nucleotide and nucleic acid metabolic process - nucleobase, nucleoside, nucleotide and nucleic acid metabolism - - - - - - - Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. - GOC:ai - - - - - GOC:dph - GOC:tb - nucleobase, nucleoside, nucleotide and nucleic acid metabolic process - - - - - - - - - - DNA metabolic process - - - Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. - DNA metabolism - GO:0006259 - GO:0055132 - biological_process - cellular DNA metabolism - - - - - - - - - - - - Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. - ISBN:0198506732 - - - - - - - - - - DNA replication - - - - - - - - - GO:0006260 - GO:0055133 - Reactome:REACT_100559 - Reactome:REACT_101280 - Reactome:REACT_101497 - Reactome:REACT_102679 - Reactome:REACT_103614 - Reactome:REACT_104547 - Reactome:REACT_105292 - Reactome:REACT_105467 - Reactome:REACT_105835 - Reactome:REACT_106018 - Reactome:REACT_106104 - Reactome:REACT_106382 - Reactome:REACT_106434 - Reactome:REACT_106732 - Reactome:REACT_107075 - Reactome:REACT_107423 - Reactome:REACT_108461 - Reactome:REACT_108634 - Reactome:REACT_108739 - Reactome:REACT_108768 - Reactome:REACT_108929 - Reactome:REACT_109137 - Reactome:REACT_112472 - Reactome:REACT_113703 - Reactome:REACT_29423 - Reactome:REACT_29444 - Reactome:REACT_29691 - Reactome:REACT_29764 - Reactome:REACT_30149 - Reactome:REACT_31024 - Reactome:REACT_31919 - Reactome:REACT_32546 - Reactome:REACT_32932 - Reactome:REACT_33572 - Reactome:REACT_33874 - Reactome:REACT_50018 - Reactome:REACT_53588 - Reactome:REACT_6729 - Reactome:REACT_6738 - Reactome:REACT_6750 - Reactome:REACT_6769 - Reactome:REACT_6798 - Reactome:REACT_6869 - Reactome:REACT_6936 - Reactome:REACT_6939 - Reactome:REACT_77532 - Reactome:REACT_79188 - Reactome:REACT_79450 - Reactome:REACT_80432 - Reactome:REACT_80571 - Reactome:REACT_80896 - Reactome:REACT_80988 - Reactome:REACT_81803 - Reactome:REACT_83095 - Reactome:REACT_84829 - Reactome:REACT_85561 - Reactome:REACT_86410 - Reactome:REACT_86739 - Reactome:REACT_87233 - Reactome:REACT_87449 - Reactome:REACT_87590 - Reactome:REACT_88085 - Reactome:REACT_88384 - Reactome:REACT_88529 - Reactome:REACT_89355 - Reactome:REACT_89439 - Reactome:REACT_89725 - Reactome:REACT_90512 - Reactome:REACT_90809 - Reactome:REACT_90838 - Reactome:REACT_91184 - Reactome:REACT_91302 - Reactome:REACT_92527 - Reactome:REACT_92644 - Reactome:REACT_92706 - Reactome:REACT_94983 - Reactome:REACT_95253 - Reactome:REACT_95329 - Reactome:REACT_96115 - Reactome:REACT_96804 - Reactome:REACT_96998 - Reactome:REACT_97204 - Reactome:REACT_97726 - Reactome:REACT_99948 - See also the biological process terms 'DNA-dependent DNA replication ; GO:0006261' and 'RNA-dependent DNA replication ; GO:0006278'. - The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. - Wikipedia:DNA_replication - biological_process - - - - - - - - Binding of ATR-ATRIP to the RPA-ssDNA complex, Danio rerio - Reactome:REACT_84829 - - - - - Recruitment and activation of Chk1, Gallus gallus - Reactome:REACT_104547 - - - - - Recruitment of Rad17-RFC complex to DNA, Bos taurus - Reactome:REACT_87590 - - - - - Activation of claspin, Canis familiaris - Reactome:REACT_106434 - - - - - Activation of ATR in response to replication stress, Saccharomyces cerevisiae - Reactome:REACT_112472 - - - - - Loading of claspin onto DNA during replication origin firing, Drosophila melanogaster - Reactome:REACT_89725 - - - - - Recruitment and activation of Chk1, Mus musculus - Reactome:REACT_96804 - - - - - Activation of ATR in response to replication stress, Canis familiaris - Reactome:REACT_91302 - - - - - Stalling of DNA replication fork and RPA binding, Danio rerio - Reactome:REACT_92706 - - - - - Recruitment of Rad17-RFC complex to DNA, Rattus norvegicus - Reactome:REACT_87449 - - - - - Loading of claspin onto DNA during replication origin firing, Canis familiaris - Reactome:REACT_53588 - - - - - Activation of ATR in response to replication stress, Caenorhabditis elegans - Reactome:REACT_97726 - - - - - Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Rattus norvegicus - Reactome:REACT_50018 - - - - - Recruitment of Rad17-RFC complex to DNA, Taeniopygia guttata - Reactome:REACT_90838 - - - - - Recruitment and activation of Chk1, Canis familiaris - Reactome:REACT_106732 - - - - - Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Homo sapiens - Reactome:REACT_6729 - - - - - Recruitment of Rad17-RFC complex to DNA, Xenopus tropicalis - Reactome:REACT_31024 - - - - - Activation of ATR in response to replication stress, Xenopus tropicalis - Reactome:REACT_105292 - - - - - Activation of claspin, Xenopus tropicalis - Reactome:REACT_101280 - - - - - Activation of ATR in response to replication stress, Dictyostelium discoideum - Reactome:REACT_79450 - - - - - Loading of claspin onto DNA during replication origin firing, Danio rerio - Reactome:REACT_105467 - - - - - Binding of ATR-ATRIP to the RPA-ssDNA complex, Homo sapiens - Reactome:REACT_6939 - - - - - Activation of ATR in response to replication stress, Taeniopygia guttata - Reactome:REACT_95253 - - - - - Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Mus musculus - Reactome:REACT_92527 - - - - - Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Xenopus tropicalis - Reactome:REACT_92644 - - - - - Loading of claspin onto DNA during replication origin firing, Xenopus tropicalis - Reactome:REACT_99948 - - - - - Recruitment and activation of Chk1, Bos taurus - Reactome:REACT_108461 - - - - - Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Drosophila melanogaster - Reactome:REACT_106382 - - - - - Stalling of DNA replication fork and RPA binding, Canis familiaris - Reactome:REACT_77532 - - - - - Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Dictyostelium discoideum - Reactome:REACT_33572 - - - - - Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Danio rerio - Reactome:REACT_90809 - - - - - Activation of claspin, Danio rerio - Reactome:REACT_89355 - - - - - Recruitment and activation of Chk1, Taeniopygia guttata - Reactome:REACT_32932 - - - - - Activation of claspin, Homo sapiens - Reactome:REACT_6750 - - - - - Loading of claspin onto DNA during replication origin firing, Gallus gallus - Reactome:REACT_97204 - - - - - Recruitment of Rad17-RFC complex to DNA, Mus musculus - Reactome:REACT_32546 - - - - - Recruitment of Rad17-RFC complex to DNA, Gallus gallus - Reactome:REACT_106018 - - - - - Stalling of DNA replication fork and RPA binding, Rattus norvegicus - Reactome:REACT_109137 - - - - - Binding of ATR-ATRIP to the RPA-ssDNA complex, Mus musculus - Reactome:REACT_96115 - - - - - Activation of claspin, Rattus norvegicus - Reactome:REACT_30149 - - - - - Activation of ATR in response to replication stress, Danio rerio - Reactome:REACT_107075 - - - - - Activation of ATR in response to replication stress, Homo sapiens - Reactome:REACT_6769 - - - - - Binding of ATR-ATRIP to the RPA-ssDNA complex, Canis familiaris - Reactome:REACT_87233 - - - - - Activation of claspin, Gallus gallus - Reactome:REACT_88529 - - - - - Stalling of DNA replication fork and RPA binding, Bos taurus - Reactome:REACT_90512 - - - - - Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Gallus gallus - Reactome:REACT_113703 - - - - - GOC:mah - The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. - - - - - Loading of claspin onto DNA during replication origin firing, Homo sapiens - Reactome:REACT_6738 - - - - - Recruitment and activation of Chk1, Sus scrofa - Reactome:REACT_80896 - - - - - Activation of ATR in response to replication stress, Mus musculus - Reactome:REACT_100559 - - - - - Binding of ATR-ATRIP to the RPA-ssDNA complex, Rattus norvegicus - Reactome:REACT_85561 - - - - - Binding of ATR-ATRIP to the RPA-ssDNA complex, Taeniopygia guttata - Reactome:REACT_29444 - - - - - Recruitment and activation of Chk1, Danio rerio - Reactome:REACT_91184 - - - - - Activation of ATR in response to replication stress, Sus scrofa - Reactome:REACT_89439 - - - - - Activation of ATR in response to replication stress, Drosophila melanogaster - Reactome:REACT_108929 - - - - - Stalling of DNA replication fork and RPA binding, Gallus gallus - Reactome:REACT_105835 - - - - - Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Caenorhabditis elegans - Reactome:REACT_107423 - - - - - Loading of claspin onto DNA during replication origin firing, Rattus norvegicus - Reactome:REACT_31919 - - - - - Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Taeniopygia guttata - Reactome:REACT_29764 - - - - - Stalling of DNA replication fork and RPA binding, Homo sapiens - Reactome:REACT_6936 - - - - - Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Bos taurus - Reactome:REACT_96998 - - - - - Stalling of DNA replication fork and RPA binding, Mus musculus - Reactome:REACT_86410 - - - - - Recruitment and activation of Chk1, Xenopus tropicalis - Reactome:REACT_33874 - - - - - Activation of claspin, Mus musculus - Reactome:REACT_80571 - - - - - Loading of claspin onto DNA during replication origin firing, Taeniopygia guttata - Reactome:REACT_80432 - - - - - Binding of ATR-ATRIP to the RPA-ssDNA complex, Bos taurus - Reactome:REACT_106104 - - - - - Stalling of DNA replication fork and RPA binding, Xenopus tropicalis - Reactome:REACT_94983 - - - - - Activation of ATR in response to replication stress, Gallus gallus - Reactome:REACT_102679 - - - - - Recruitment and activation of Chk1, Rattus norvegicus - Reactome:REACT_86739 - - - - - Recruitment of Rad17-RFC complex to DNA, Danio rerio - Reactome:REACT_83095 - - - - - Activation of ATR in response to replication stress, Bos taurus - Reactome:REACT_108768 - - - - - Stalling of DNA replication fork and RPA binding, Taeniopygia guttata - Reactome:REACT_103614 - - - - - Binding of ATR-ATRIP to the RPA-ssDNA complex, Xenopus tropicalis - Reactome:REACT_108739 - - - - - Activation of ATR in response to replication stress, Schizosaccharomyces pombe - Reactome:REACT_29423 - - - - - Loading of claspin onto DNA during replication origin firing, Mus musculus - Reactome:REACT_108634 - - - - - Recruitment and activation of Chk1, Homo sapiens - Reactome:REACT_6869 - - - - - Activation of claspin, Taeniopygia guttata - Reactome:REACT_95329 - - - - - Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Schizosaccharomyces pombe - Reactome:REACT_88384 - - - - - Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Canis familiaris - Reactome:REACT_79188 - - - - - Activation of ATR in response to replication stress, Rattus norvegicus - Reactome:REACT_29691 - - - - - Activation of claspin, Bos taurus - Reactome:REACT_101497 - - - - - Recruitment of Rad17-RFC complex to DNA, Canis familiaris - Reactome:REACT_81803 - - - - - Recruitment of Rad17-RFC complex to DNA, Homo sapiens - Reactome:REACT_6798 - - - - - Loading of claspin onto DNA during replication origin firing, Bos taurus - Reactome:REACT_80988 - - - - - Binding of ATR-ATRIP to the RPA-ssDNA complex, Gallus gallus - Reactome:REACT_88085 - - - - - - - - - - DNA amplification - - GO:0006277 - The process in which the number of copies of a gene is increased in certain cells as extra copies of DNA are made in response to certain signals of cell development or of stress from the environment. - biological_process - - - - - ISBN:0721601464 - The process in which the number of copies of a gene is increased in certain cells as extra copies of DNA are made in response to certain signals of cell development or of stress from the environment. - - - - - - - - - - RNA-dependent DNA replication - - A DNA replication process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. - GO:0006278 - Reactome:REACT_6880 - Reactome:REACT_9037 - Reactome:REACT_9055 - biological_process - - - - - Minus-strand DNA synthesis, Homo sapiens - Reactome:REACT_9055 - - - - - A DNA replication process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. - GOC:mah - ISBN:0198506732 - - - - - Reverse Transcription of HIV RNA, Homo sapiens - Reactome:REACT_6880 - - - - - Plus-strand DNA synthesis, Homo sapiens - Reactome:REACT_9037 - - - - - - - - - - DNA catabolic process - - - - - - - - - - DNA breakdown - DNA catabolism - DNA degradation - GO:0006308 - The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. - biological_process - - - - - GOC:go_curators - ISBN:0198506732 - The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. - - - - - - - - - - apoptotic DNA fragmentation - - - - - - - - - - - - - - - - - - - DNA catabolic process during apoptosis - DNA catabolism during apoptosis - DNA fragmentation - DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases. In human, these include DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) and endonuclease G (Endo G) (reviewed in PMID:15723341). Caution is needed when apoptotic DNA laddering assays show presence of fragmented DNA. A positive assay may simply reflect the end point of a whole apoptotic process. Unless clear experimental evidence is available to show that a gene product is directly involved in fragmenting DNA, please do not annotate to GO:0006309 'apoptotic DNA fragmentation' and consider annotating instead to a more upstream process such as, e.g., GO:0042981 'regulation of apoptotic process', GO:0006915 'apoptotic process', GO:0097190 'apoptotic signaling pathway'. Also, note that gene products involved in compartmentalization of apoptotic nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341). - DNA fragmentation involved in apoptotic nuclear change - GO:0006309 - GO:0008178 - Reactome:REACT_102783 - Reactome:REACT_105342 - Reactome:REACT_110358 - Reactome:REACT_113418 - Reactome:REACT_1213 - Reactome:REACT_28808 - Reactome:REACT_33113 - Reactome:REACT_92967 - Reactome:REACT_94135 - Reactome:REACT_98713 - Reactome:REACT_99275 - Reactome:REACT_99925 - The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments. - biological_process - chromatinolysis - endonucleolytic DNA catabolic process involved in apoptosis - - - - Apoptosis induced DNA fragmentation, Plasmodium falciparum - Reactome:REACT_113418 - - - - - GOC:mtg_apoptosis - chromatinolysis - - - - - Apoptosis induced DNA fragmentation, Mus musculus - Reactome:REACT_33113 - - - - - Apoptosis induced DNA fragmentation, Sus scrofa - Reactome:REACT_105342 - - - - - Apoptosis induced DNA fragmentation, Xenopus tropicalis - Reactome:REACT_110358 - - - - - Apoptosis induced DNA fragmentation, Danio rerio - Reactome:REACT_99925 - - - - - Apoptosis induced DNA fragmentation, Homo sapiens - Reactome:REACT_1213 - - - - - GOC:dph - GOC:mah - GOC:mtg_apoptosis - GOC:tb - ISBN:0721639976 - PMID:15723341 - PMID:23379520 - The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments. - - - - - DNA fragmentation involved in apoptotic nuclear change - GOC:cjm - GOC:dph - GOC:tb - - - - - Apoptosis induced DNA fragmentation, Gallus gallus - Reactome:REACT_99275 - - - - - Apoptosis induced DNA fragmentation, Bos taurus - Reactome:REACT_102783 - - - - - Apoptosis induced DNA fragmentation, Taeniopygia guttata - Reactome:REACT_94135 - - - - - Apoptosis induced DNA fragmentation, Rattus norvegicus - Reactome:REACT_28808 - - - - - Apoptosis induced DNA fragmentation, Drosophila melanogaster - Reactome:REACT_92967 - - - - - Apoptosis induced DNA fragmentation, Canis familiaris - Reactome:REACT_98713 - - - - - - - - - - DNA packaging - - - - - - - - Any process in which DNA and associated proteins are formed into a compact, orderly structure. - DNA condensation - DNA organisation - DNA organization - GO:0006323 - biological_process - - - - - Any process in which DNA and associated proteins are formed into a compact, orderly structure. - GOC:mah - ISBN:0815316194 - - - - - DNA organization - GOC:curators - - - - - DNA organisation - GOC:curators - - - - - - - - - - transcription, DNA-templated - - - - - - - - - DNA-dependent transcription - GO:0006350 - GO:0006351 - GO:0061018 - GO:0061022 - The cellular synthesis of RNA on a template of DNA. - Wikipedia:Transcription_(genetics) - biological_process - cellular transcription - cellular transcription, DNA-dependent - transcription - transcription regulator activity - transcription, DNA-dependent - - - - - - - - GOC:jl - GOC:txnOH - The cellular synthesis of RNA on a template of DNA. - - - - - GOC:txnOH - transcription, DNA-dependent - - - - - - - - - - regulation of transcription, DNA-templated - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. - GO:0006355 - GO:0032583 - GO:0045449 - GO:0061019 - biological_process - regulation of cellular transcription, DNA-dependent - regulation of gene-specific transcription - regulation of transcription, DNA-dependent - transcriptional control - - - - - - Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. - GOC:go_curators - GOC:txnOH - - - - - GOC:txnOH - regulation of transcription, DNA-dependent - - - - - - - - - - protein targeting - - - GO:0006605 - Note that protein targeting encompasses the transport of the protein to the specified location, and may also include additional steps such as protein processing. - The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif. - Wikipedia:Protein_targeting - biological_process - nascent polypeptide association - protein sorting along secretory pathway - - - - - - - - - GOC:ma - The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif. - - - - - - - - - - protein import into nucleus - - - - - - - - - - - - - GO:0006606 - The directed movement of a protein from the cytoplasm to the nucleus. - biological_process - establishment of protein localization to nucleus - protein import into cell nucleus - protein nucleus import - protein transport from cytoplasm to nucleus - - - - GOC:jl - The directed movement of a protein from the cytoplasm to the nucleus. - - - - - GOC:mah - establishment of protein localization to nucleus - - - - - - - - - - cellular aromatic compound metabolic process - - GO:0006725 - The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. - aromatic compound metabolism - aromatic hydrocarbon metabolic process - aromatic hydrocarbon metabolism - biological_process - - - - - - GOC:ai - ISBN:0198506732 - The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. - - - - - - - - - - nitrogen compound metabolic process - - GO:0006807 - Note that amino acid and derivative metabolism should not be annotated here. Instead use the 'amino acid and derivative metabolism' node. - The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. - biological_process - nitrogen compound metabolism - - - - - - - CHEBI:51143 - GOC:go_curators - GOC:jl - ISBN:0198506732 - The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. - - - - - - - - - - transport - - GO:0006810 - GO:0015457 - GO:0015460 - The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. - auxiliary transport protein activity - biological_process - small molecule transport - solute:solute exchange - transport accessory protein activity - - - - - - - - - - - - GOC:dph - GOC:jl - GOC:mah - The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. - - - - - GOC:mah - auxiliary transport protein activity - - - - - GOC:mah - transport accessory protein activity - - - - - - - - - - intracellular protein transport - - - - - - - - - - - - - - - - - - - - - - - - - - - GO:0006886 - GO:0032779 - The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. - biological_process - copper-induced intracellular protein transport - - - - - GOC:mah - The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. - - - - - GOC:al - copper-induced intracellular protein transport - - - - - - - - - - nucleocytoplasmic transport - - - - - - - - - GO:0000063 - GO:0006913 - Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane, and is not traversed. - The directed movement of molecules between the nucleus and the cytoplasm. - biological_process - nucleocytoplasmic shuttling - - - - - - - GOC:go_curators - The directed movement of molecules between the nucleus and the cytoplasm. - - - - - - - - - - apoptotic process - - A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. - GO:0006915 - GO:0006917 - GO:0008632 - Reactome:REACT_100045 - Reactome:REACT_100962 - Reactome:REACT_101249 - Reactome:REACT_104187 - Reactome:REACT_105149 - Reactome:REACT_106405 - Reactome:REACT_106672 - Reactome:REACT_107264 - Reactome:REACT_108651 - Reactome:REACT_109165 - Reactome:REACT_110081 - Reactome:REACT_111964 - Reactome:REACT_13526 - Reactome:REACT_13638 - Reactome:REACT_13643 - Reactome:REACT_28087 - Reactome:REACT_28795 - Reactome:REACT_28816 - Reactome:REACT_30266 - Reactome:REACT_30361 - Reactome:REACT_30371 - Reactome:REACT_30548 - Reactome:REACT_30763 - Reactome:REACT_31349 - Reactome:REACT_34139 - Reactome:REACT_578 - Reactome:REACT_77132 - Reactome:REACT_77313 - Reactome:REACT_77415 - Reactome:REACT_78287 - Reactome:REACT_78802 - Reactome:REACT_79809 - Reactome:REACT_82724 - Reactome:REACT_83328 - Reactome:REACT_85877 - Reactome:REACT_86749 - Reactome:REACT_86873 - Reactome:REACT_87570 - Reactome:REACT_88740 - Reactome:REACT_88784 - Reactome:REACT_89196 - Reactome:REACT_90267 - Reactome:REACT_91011 - Reactome:REACT_91243 - Reactome:REACT_93937 - Reactome:REACT_94099 - Reactome:REACT_95069 - Reactome:REACT_95675 - Reactome:REACT_97627 - Reactome:REACT_99784 - Reactome:REACT_99799 - Wikipedia:Apoptosis - activation of apoptosis - apoptosis - apoptosis activator activity - apoptosis signaling - apoptotic cell death - apoptotic program - apoptotic programmed cell death - biological_process - cell suicide - cellular suicide - commitment to apoptosis - induction of apoptosis - induction of apoptosis by p53 - programmed cell death by apoptosis - signaling (initiator) caspase activity - type I programmed cell death - - - - NRAGE signals death through JNK, Arabidopsis thaliana - Reactome:REACT_109165 - - - - - NRIF signals cell death from the nucleus, Homo sapiens - Reactome:REACT_13643 - - - - - NRIF signals cell death from the nucleus, Gallus gallus - Reactome:REACT_86873 - - - - - NRAGE signals death through JNK, Drosophila melanogaster - Reactome:REACT_77132 - - - - - NRAGE signals death through JNK, Gallus gallus - Reactome:REACT_34139 - - - - - Apoptosis, Gallus gallus - Reactome:REACT_78287 - - - - - NRAGE signals death through JNK, Saccharomyces cerevisiae - Reactome:REACT_30371 - - - - - Apoptosis, Caenorhabditis elegans - Reactome:REACT_91011 - - - - - NRAGE signals death through JNK, Taeniopygia guttata - Reactome:REACT_104187 - - - - - Apoptosis, Drosophila melanogaster - Reactome:REACT_100045 - - - - - Apoptosis, Xenopus tropicalis - Reactome:REACT_95069 - - - - - NRAGE signals death through JNK, Xenopus tropicalis - Reactome:REACT_106405 - - - - - NRAGE signals death through JNK, Oryza sativa - Reactome:REACT_30763 - - - - - Apoptosis, Danio rerio - Reactome:REACT_28816 - - - - - NRIF signals cell death from the nucleus, Canis familiaris - Reactome:REACT_77415 - - - - - Apoptosis, Rattus norvegicus - Reactome:REACT_86749 - - - - - NRIF signals cell death from the nucleus, Bos taurus - Reactome:REACT_97627 - - - - - NRAGE signals death through JNK, Schizosaccharomyces pombe - Reactome:REACT_110081 - - - - - NADE modulates death signalling, Canis familiaris - Reactome:REACT_78802 - - - - - NRAGE signals death through JNK, Caenorhabditis elegans - Reactome:REACT_30548 - - - - - NRAGE signals death through JNK, Sus scrofa - Reactome:REACT_99799 - - - - - Apoptosis, Taeniopygia guttata - Reactome:REACT_82724 - - - - - GOC:sl - apoptotic cell death - - - - - NRAGE signals death through JNK, Rattus norvegicus - Reactome:REACT_85877 - - - - - GOC:add - apoptotic program - - - - - NRIF signals cell death from the nucleus, Sus scrofa - Reactome:REACT_88740 - - - - - Apoptosis, Plasmodium falciparum - Reactome:REACT_95675 - - - - - NADE modulates death signalling, Mus musculus - Reactome:REACT_91243 - - - - - Apoptosis, Saccharomyces cerevisiae - Reactome:REACT_28087 - - - - - NRAGE signals death through JNK, Homo sapiens - Reactome:REACT_13638 - - - - - A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. - GOC:dhl - GOC:ecd - GOC:go_curators - GOC:mtg_apoptosis - GOC:tb - ISBN:0198506732 - PMID:18846107 - PMID:21494263 - - - - - NRAGE signals death through JNK, Mus musculus - Reactome:REACT_108651 - - - - - NRIF signals cell death from the nucleus, Taeniopygia guttata - Reactome:REACT_90267 - - - - - NRAGE signals death through JNK, Canis familiaris - Reactome:REACT_31349 - - - - - NRAGE signals death through JNK, Bos taurus - Reactome:REACT_99784 - - - - - Apoptosis, Dictyostelium discoideum - Reactome:REACT_89196 - - - - - Apoptosis, Schizosaccharomyces pombe - Reactome:REACT_79809 - - - - - NRIF signals cell death from the nucleus, Rattus norvegicus - Reactome:REACT_87570 - - - - - Apoptosis, Sus scrofa - Reactome:REACT_83328 - - - - - NADE modulates death signalling, Bos taurus - Reactome:REACT_77313 - - - - - Apoptosis, Bos taurus - Reactome:REACT_93937 - - - - - NRIF signals cell death from the nucleus, Mus musculus - Reactome:REACT_88784 - - - - - NADE modulates death signalling, Rattus norvegicus - Reactome:REACT_105149 - - - - - NRAGE signals death through JNK, Dictyostelium discoideum - Reactome:REACT_111964 - - - - - NRIF signals cell death from the nucleus, Danio rerio - Reactome:REACT_101249 - - - - - NRIF signals cell death from the nucleus, Xenopus tropicalis - Reactome:REACT_107264 - - - - - Apoptosis, Mus musculus - Reactome:REACT_100962 - - - - - NADE modulates death signalling, Homo sapiens - Reactome:REACT_13526 - - - - - Apoptosis, Homo sapiens - Reactome:REACT_578 - - - - - Apoptosis, Oryza sativa - Reactome:REACT_28795 - - - - - NRAGE signals death through JNK, Danio rerio - Reactome:REACT_94099 - - - - - Apoptosis, Canis familiaris - Reactome:REACT_30361 - - - - - NADE modulates death signalling, Sus scrofa - Reactome:REACT_106672 - - - - - Apoptosis, Arabidopsis thaliana - Reactome:REACT_30266 - - - - - - - - - - cellular component disassembly involved in execution phase of apoptosis - - - - - - - - - - - - - - - - - - - GO:0006921 - Reactome:REACT_100800 - Reactome:REACT_108463 - Reactome:REACT_29660 - Reactome:REACT_77151 - Reactome:REACT_78666 - Reactome:REACT_79472 - Reactome:REACT_79859 - Reactome:REACT_80493 - Reactome:REACT_81021 - Reactome:REACT_81052 - Reactome:REACT_84120 - Reactome:REACT_89424 - Reactome:REACT_90988 - Reactome:REACT_92689 - Reactome:REACT_93576 - Reactome:REACT_94230 - Reactome:REACT_97703 - Reactome:REACT_995 - The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis. - biological_process - cellular component disassembly involved in apoptosis - cellular component disassembly involved in apoptotic process - disassembly of cell structures - - - - Apoptotic execution phase, Canis familiaris - Reactome:REACT_81052 - - - - - Apoptotic execution phase, Gallus gallus - Reactome:REACT_93576 - - - - - Apoptotic execution phase, Arabidopsis thaliana - Reactome:REACT_89424 - - - - - Apoptotic execution phase, Oryza sativa - Reactome:REACT_29660 - - - - - Apoptotic execution phase, Danio rerio - Reactome:REACT_100800 - - - - - GOC:dph - GOC:mah - GOC:mtg_apoptosis - GOC:tb - The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis. - - - - - Apoptotic execution phase, Caenorhabditis elegans - Reactome:REACT_92689 - - - - - Apoptotic execution phase, Bos taurus - Reactome:REACT_94230 - - - - - Apoptotic execution phase, Taeniopygia guttata - Reactome:REACT_108463 - - - - - Apoptotic execution phase, Rattus norvegicus - Reactome:REACT_79859 - - - - - Apoptotic execution phase, Homo sapiens - Reactome:REACT_995 - - - - - Apoptotic execution phase, Saccharomyces cerevisiae - Reactome:REACT_78666 - - - - - Apoptotic execution phase, Sus scrofa - Reactome:REACT_77151 - - - - - Apoptotic execution phase, Xenopus tropicalis - Reactome:REACT_84120 - - - - - Apoptotic execution phase, Schizosaccharomyces pombe - Reactome:REACT_79472 - - - - - Apoptotic execution phase, Dictyostelium discoideum - Reactome:REACT_80493 - - - - - Apoptotic execution phase, Mus musculus - Reactome:REACT_97703 - - - - - Apoptotic execution phase, Drosophila melanogaster - Reactome:REACT_81021 - - - - - Apoptotic execution phase, Plasmodium falciparum - Reactome:REACT_90988 - - - - - - - - - - movement of cell or subcellular component - - GO:0006928 - Note that in GO cellular components include whole cells (cell is_a cellular component). - The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore. - biological_process - cell movement - cellular component motion - cellular component movement - - - - - - - - GOC:dph - GOC:jl - cellular component motion - - - - - GOC:dgh - GOC:dph - GOC:jl - GOC:mlg - The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore. - - - - - - - - - - substrate-dependent cell migration - - GO:0006929 - The orderly movement of a cell from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate. - biological_process - substrate-bound cell migration - - - - ISBN:0815316194 - PMID:11944043 - PMID:14657486 - The orderly movement of a cell from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate. - - - - - GOC:curators - substrate-bound cell migration - - - - - - - - - - substrate-dependent cell migration, cell extension - - - - - - - - GO:0006930 - The formation of a cell surface protrusion, such as a lamellipodium or filopodium, at the leading edge of a migrating cell. - biological_process - substrate-bound cell migration, cell extension - - - - GOC:curators - substrate-bound cell migration, cell extension - - - - - ISBN:0815316194 - PMID:11944043 - PMID:14657486 - The formation of a cell surface protrusion, such as a lamellipodium or filopodium, at the leading edge of a migrating cell. - - - - - - - - - - response to stress - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). - GO:0006950 - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - biological_process - response to abiotic stress - response to biotic stress - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). - GOC:mah - - - - - - - - - - immune response - - - Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. - GO:0006955 - This term was improved by GO_REF:0000022. It was redefined and moved. - biological_process - - - - Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. - GOC:add - GOC:mtg_15nov05 - GO_REF:0000022 - - - - - - - - - - cellular response to DNA damage stimulus - - Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. - DNA damage response - GO:0006974 - GO:0034984 - biological_process - cellular DNA damage response - response to DNA damage stimulus - response to genotoxic stress - - - - - - Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. - GOC:go_curators - - - - - - - - - - organelle organization - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. - GO:0006996 - biological_process - organelle organisation - organelle organization and biogenesis - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. - GOC:mah - - - - - GOC:dph - GOC:jl - GOC:mah - organelle organization and biogenesis - - - - - GOC:curators - organelle organisation - - - - - - - - - - nucleus organization - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus. - GO:0006997 - GO:0048287 - biological_process - nuclear morphology - nuclear organisation - nuclear organization - nuclear organization and biogenesis - nucleus organization and biogenesis - - - - - - - - GOC:curators - nuclear organisation - - - - - GOC:mah - nucleus organization and biogenesis - - - - - GOC:mah - nuclear organization and biogenesis - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus. - GOC:dph - GOC:ems - GOC:jl - GOC:mah - - - - - GOC:curators - nuclear organization - - - - - - - - - - nuclear envelope organization - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope. - GO:0006998 - biological_process - nuclear envelope organisation - nuclear envelope organization and biogenesis - - - - GOC:mah - nuclear envelope organization and biogenesis - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope. - GOC:dph - GOC:ems - GOC:jl - GOC:mah - - - - - GOC:mah - nuclear envelope organisation - - - - - - - - - - plasma membrane organization - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane. - GO:0007009 - biological_process - plasma membrane organisation - plasma membrane organization and biogenesis - - - - - - - GOC:mah - plasma membrane organization and biogenesis - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane. - GOC:dph - GOC:jl - GOC:mah - - - - - GOC:curators - plasma membrane organisation - - - - - - - - - - cytoskeleton organization - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. - GO:0007010 - biological_process - cytoskeletal organization and biogenesis - cytoskeletal regulator activity - cytoskeleton organisation - cytoskeleton organization and biogenesis - - - - - - - - - - - GOC:mah - cytoskeleton organization and biogenesis - - - - - GOC:curators - cytoskeleton organisation - - - - - GOC:mah - cytoskeletal organization and biogenesis - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. - GOC:dph - GOC:jl - GOC:mah - - - - - - - - - - microtubule-based process - - Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. - GO:0007017 - biological_process - - - - - Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. - GOC:mah - - - - - - - - - - endoplasmic reticulum organization - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum. - ER organisation - ER organization and biogenesis - GO:0007029 - biological_process - endoplasmic reticulum morphology - endoplasmic reticulum organisation - endoplasmic reticulum organization and biogenesis - - - - - GOC:mah - endoplasmic reticulum organization and biogenesis - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum. - GOC:dph - GOC:jl - GOC:mah - - - - - ER organisation - GOC:curators - - - - - ER organization and biogenesis - GOC:mah - - - - - GOC:curators - endoplasmic reticulum organisation - - - - - - - - - - peroxisome organization - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. - GO:0007031 - biological_process - peroxisome organisation - peroxisome organization and biogenesis - peroxisome-assembly ATPase activity - - - - - - - GOC:mah - peroxisome organization and biogenesis - - - - - GOC:curators - peroxisome organisation - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. - GOC:mah - - - - - - - - - - cell cycle - - GO:0007049 - The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. - Wikipedia:Cell_cycle - biological_process - cell-division cycle - - - - - - - - - - - - GOC:go_curators - GOC:mtg_cell_cycle - The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. - - - - - - - - - - chromosome segregation - - GO:0007059 - The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. - Wikipedia:Chromosome_segregation - biological_process - chromosome division - chromosome transmission - - - - - - - - - - GOC:jl - GOC:mah - GOC:mtg_cell_cycle - GOC:vw - The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. - - - - - - - - - - mitotic nuclear division - - - - - - - - - - - - - - - - - - - - - A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell. - GO:0007067 - Wikipedia:Mitosis - biological_process - mitosis - - - - - - A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell. - GOC:dph - GOC:ma - GOC:mah - ISBN:0198547684 - - - - - - - - - - mitotic chromosome condensation - - - - - - - - - - - - - - - - - - - - - - - - - - GO:0007076 - The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells. - biological_process - - - - GOC:mah - ISBN:0815316194 - The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells. - - - - - - - - - - mitotic metaphase plate congression - - - - - - - - - - - - - - - - - - - - - - - - - - - GO:0007080 - The cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis. - biological_process - - - - GOC:mah - ISBN:0815316194 - The cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis. - - - - - - - - - - mitotic chromosome decondensation - - - - - - - - - - - - - - - - - - - - - - - - - - - GO:0007083 - The cell cycle process in which chromosome structure is altered from the condensed form taken on during mitosis to the relaxed disperse form held in resting cells. - biological_process - - - - GOC:ai - The cell cycle process in which chromosome structure is altered from the condensed form taken on during mitosis to the relaxed disperse form held in resting cells. - - - - - - - - - - centrosome cycle - - - - GO:0007098 - The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle. - biological_process - - - - ISBN:0815316194 - The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle. - - - - - - - - - - centriole replication - - - - - - - - - - GO:0007099 - The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. - biological_process - centriole duplication - - - - GOC:kmv - ISBN:0815316194 - The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. - - - - - - - - - - cell communication - - Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. - GO:0007154 - Wikipedia:Cell_signaling - biological_process - - - - - - - - Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. - GOC:mah - - - - - - - - - - cell adhesion - - GO:0007155 - The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. - Wikipedia:Cell_adhesion - biological_process - cell adhesion molecule activity - - - - - - - - - - - GOC:hb - GOC:pf - The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. - - - - - - - - - - cell-matrix adhesion - - GO:0007160 - The binding of a cell to the extracellular matrix via adhesion molecules. - biological_process - - - - - GOC:hb - The binding of a cell to the extracellular matrix via adhesion molecules. - - - - - - - - - - establishment or maintenance of cell polarity - - Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. - GO:0007163 - GO:0030012 - GO:0030467 - biological_process - cell polarity - establishment and/or maintenance of cell polarity - establishment and/or maintenance of cell polarization - - - - - GOC:mah - GOC:vw - cell polarity - - - - - Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. - GOC:mah - - - - - - - - - - signal transduction - - - - - - - - - - - - - - - - - - - - GO:0007165 - GO:0023033 - Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not. - Reactome:REACT_100624 - Reactome:REACT_102354 - Reactome:REACT_112130 - Reactome:REACT_112549 - Reactome:REACT_113151 - Reactome:REACT_113601 - Reactome:REACT_113964 - Reactome:REACT_114657 - Reactome:REACT_114690 - Reactome:REACT_114820 - Reactome:REACT_114910 - Reactome:REACT_115037 - Reactome:REACT_115147 - Reactome:REACT_12478 - Reactome:REACT_31232 - Reactome:REACT_78535 - Reactome:REACT_89740 - Reactome:REACT_93680 - Reactome:REACT_98872 - The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. - Wikipedia:Signal_transduction - biological_process - signaling cascade - signaling pathway - signalling cascade - signalling pathway - - - - - - - - - - - EGFR interacts with phospholipase C-gamma, Homo sapiens - Reactome:REACT_12478 - - - - - EGFR interacts with phospholipase C-gamma, Gallus gallus - Reactome:REACT_100624 - - - - - EGFR interacts with phospholipase C-gamma, Mycobacterium tuberculosis - Reactome:REACT_113151 - - - - - EGFR interacts with phospholipase C-gamma, Dictyostelium discoideum - Reactome:REACT_114657 - - - - - EGFR interacts with phospholipase C-gamma, Sus scrofa - Reactome:REACT_114820 - - - - - EGFR interacts with phospholipase C-gamma, Danio rerio - Reactome:REACT_93680 - - - - - EGFR interacts with phospholipase C-gamma, Saccharomyces cerevisiae - Reactome:REACT_114690 - - - - - EGFR interacts with phospholipase C-gamma, Rattus norvegicus - Reactome:REACT_31232 - - - - - EGFR interacts with phospholipase C-gamma, Taeniopygia guttata - Reactome:REACT_89740 - - - - - EGFR interacts with phospholipase C-gamma, Canis familiaris - Reactome:REACT_102354 - - - - - GOC:go_curators - GOC:mtg_signaling_feb11 - The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. - - - - - EGFR interacts with phospholipase C-gamma, Oryza sativa - Reactome:REACT_112130 - - - - - EGFR interacts with phospholipase C-gamma, Mus musculus - Reactome:REACT_98872 - - - - - EGFR interacts with phospholipase C-gamma, Caenorhabditis elegans - Reactome:REACT_114910 - - - - - EGFR interacts with phospholipase C-gamma, Plasmodium falciparum - Reactome:REACT_115037 - - - - - EGFR interacts with phospholipase C-gamma, Bos taurus - Reactome:REACT_113964 - - - - - EGFR interacts with phospholipase C-gamma, Xenopus tropicalis - Reactome:REACT_78535 - - - - - GOC:mah - signalling pathway - - - - - EGFR interacts with phospholipase C-gamma, Arabidopsis thaliana - Reactome:REACT_112549 - - - - - EGFR interacts with phospholipase C-gamma, Schizosaccharomyces pombe - Reactome:REACT_115147 - - - - - EGFR interacts with phospholipase C-gamma, Drosophila melanogaster - Reactome:REACT_113601 - - - - - - - - - - I-kappaB kinase/NF-kappaB signaling - - - - - - - - GO:0007249 - I-kappaB kinase/NF-kappaB cascade - I-kappaB kinase/NF-kappaB signal transduction - NF-kappaB cascade - Reactome:REACT_13696.1 - Reactome:REACT_25351 - The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. - activation of the inhibitor of kappa kinase - biological_process - canonical NF-kappaB signaling cascade - p50-dependent NF-kappaB signaling - - - - TRAF6 mediated induction of TAK1 complex, Homo sapiens - Reactome:REACT_25351 - - - - - GOC:signaling - I-kappaB kinase/NF-kappaB cascade - - - - - NF-kB is activated and signals survival, Homo sapiens - Reactome:REACT_13696.1 - - - - - GOC:bf - canonical NF-kappaB signaling cascade - - - - - PMID:18292232 - p50-dependent NF-kappaB signaling - - - - - GOC:bf - GOC:jl - PMID:12773372 - Reactome:REACT_13696.1 - The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. - - - - - GOC:signaling - I-kappaB kinase/NF-kappaB signal transduction - - - - - - - - - - cytoplasmic sequestering of NF-kappaB - - - - - - - - - GO:0007253 - The selective interaction of the transcription factor NF-kappaB with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus. - biological_process - cytoplasmic NF-kappaB retention - cytoplasmic NF-kappaB sequestration - cytoplasmic NF-kappaB storage - cytoplasmic retention of NF-kappaB - cytoplasmic sequestration of NF-kappaB - cytoplasmic storage of NF-kappaB - maintenance of NF-kappaB location in cytoplasm - - - - GOC:dph - GOC:tb - maintenance of NF-kappaB location in cytoplasm - - - - - GOC:jl - The selective interaction of the transcription factor NF-kappaB with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus. - - - - - - - - - - protein localization - - Any process in which a protein is transported to, or maintained in, a specific location. - GO:0008104 - biological_process - establishment and maintenance of protein localization - protein localisation - - - - - Any process in which a protein is transported to, or maintained in, a specific location. - GOC:ai - - - - - GOC:mah - protein localisation - - - - - - - - - - biological_process - Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end. - GO:0000004 - GO:0007582 - GO:0008150 - Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. Note that when this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this. - Wikipedia:Biological_process - biological process - biological_process - physiological process - - - - - - - - - - - - - - Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end. - GOC:go_curators - GOC:isa_complete - - - - - - - - - - metabolic process - - - GO:0008152 - Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions. - The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. - Wikipedia:Metabolism - biological_process - metabolic process resulting in cell growth - metabolism - metabolism resulting in cell growth - - - - - - - - GOC:go_curators - ISBN:0198547684 - The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. - - - - - - - - - - cell death - - - Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as "apoptotic bodies"); and/or (3) its corpse (or its fragments) have been engulfed by an adjacent cell in vivo. - GO:0008219 - This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term. - accidental cell death - biological_process - necrosis - - - - - - - - Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as "apoptotic bodies"); and/or (3) its corpse (or its fragments) have been engulfed by an adjacent cell in vivo. - GOC:mah - GOC:mtg_apoptosis - - - - - - - - - - DNA binding, bending - - DNA bending activity - DNA bending involving DNA binding - GO:0008301 - The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence. - molecular_function - - - - - GOC:krc - GOC:vw - PMID:10710711 - PMID:19037758 - The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence. - - - - - - - - - - release of cytoplasmic sequestered NF-kappaB - - - - - - - - - - - - - - - - GO:0008588 - The release of NF-kappaB from specific molecules in the cytoplasm to which it was bound, thereby allowing its translocation into the nucleus. - activation of NF-kappa B - biological_process - negative regulation of cytoplasmic NF-kappaB retention - negative regulation of cytoplasmic NF-kappaB sequestering - negative regulation of cytoplasmic NF-kappaB sequestration - negative regulation of cytoplasmic NF-kappaB storage - release of NF-kappaB sequestered in cytoplasm - release of NF-kappaB stored in cytoplasm - - - - GOC:jl - The release of NF-kappaB from specific molecules in the cytoplasm to which it was bound, thereby allowing its translocation into the nucleus. - - - - - - - - - - catabolic process - - GO:0009056 - The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism. - Wikipedia:Catabolism - biological_process - breakdown - catabolism - degradation - - - - - - - - - ISBN:0198547684 - The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism. - - - - - - - - - - macromolecule catabolic process - - - GO:0009057 - GO:0043285 - The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - biological_process - biopolymer catabolic process - macromolecule breakdown - macromolecule catabolism - macromolecule degradation - - - - - GOC:mtg_chebi_dec09 - biopolymer catabolic process - - - - - CHEBI:33694 - GOC:mah - The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - - - - - - - - - - biosynthetic process - - GO:0009058 - The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. - Wikipedia:Anabolism - anabolism - biological_process - biosynthesis - formation - synthesis - - - - - - - - - GOC:curators - ISBN:0198547684 - The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. - - - - - - - - - - macromolecule biosynthetic process - - - GO:0009059 - GO:0043284 - The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - biological_process - biopolymer biosynthetic process - macromolecule anabolism - macromolecule biosynthesis - macromolecule formation - macromolecule synthesis - - - - - CHEBI:33694 - GOC:mah - The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - - - - - GOC:mtg_chebi_dec09 - biopolymer biosynthetic process - - - - - - - - - - protein secretion - - - GO:0009306 - GO:0045166 - GO:0045731 - The controlled release of proteins from a cell. - biological_process - glycoprotein secretion - protein secretion during cell fate commitment - protein secretion resulting in cell fate commitment - - - - - - GOC:ai - The controlled release of proteins from a cell. - - - - - - - - - - response to biotic stimulus - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. - GO:0009607 - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - biological_process - response to biotic stress - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. - GOC:hb - - - - - - - - - - anatomical structure morphogenesis - - - - - - - - GO:0009653 - The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form. - Wikipedia:Morphogenesis - anatomical structure organization - biological_process - embryogenesis and morphogenesis - morphogenesis - - - - - - GOC:go_curators - ISBN:0521436125 - The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form. - - - - - - - - - - unidimensional cell growth - - - - GO:0009826 - The process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis, resulting in the morphogenesis of the cell. - Unidimensional cell growth refers to a change in both cell size and cell shape. For cell shape changes where cell size is not affected, consider instead the term 'regulation of cell shape ; GO:0008360' and its children. - biological_process - cell elongation - cell growth along one axis - cell growth in one dimension - cell morphogenesis by unidimensional growth - polar cell growth - polarized cell growth - - - - - ISBN:0943088399 - The process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis, resulting in the morphogenesis of the cell. - - - - - GOC:dph - GOC:tb - cell morphogenesis by unidimensional growth - - - - - - - - - - regulation of biosynthetic process - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. - GO:0009889 - biological_process - regulation of anabolism - regulation of biosynthesis - regulation of formation - regulation of synthesis - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. - GOC:go_curators - - - - - - - - - - negative regulation of biosynthetic process - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances. - GO:0009890 - biological_process - down regulation of biosynthetic process - down-regulation of biosynthetic process - downregulation of biosynthetic process - inhibition of biosynthetic process - negative regulation of anabolism - negative regulation of biosynthesis - negative regulation of formation - negative regulation of synthesis - - - - - Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances. - GOC:go_curators - - - - - - - - - - positive regulation of biosynthetic process - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. - GO:0009891 - activation of biosynthetic process - biological_process - positive regulation of anabolism - positive regulation of biosynthesis - positive regulation of formation - positive regulation of synthesis - stimulation of biosynthetic process - up regulation of biosynthetic process - up-regulation of biosynthetic process - upregulation of biosynthetic process - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. - GOC:go_curators - - - - - - - - - - negative regulation of metabolic process - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. - GO:0009892 - biological_process - down regulation of metabolic process - down-regulation of metabolic process - downregulation of metabolic process - inhibition of metabolic process - negative regulation of metabolism - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. - GOC:go_curators - - - - - - - - - - positive regulation of metabolic process - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. - GO:0009893 - activation of metabolic process - biological_process - positive regulation of metabolism - stimulation of metabolic process - up regulation of metabolic process - up-regulation of metabolic process - upregulation of metabolic process - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. - GOC:go_curators - - - - - - - - - - regulation of signal transduction - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of signal transduction. - GO:0009966 - GO:0035466 - biological_process - regulation of signaling pathway - regulation of signalling pathway - - - - - GOC:mah - regulation of signalling pathway - - - - - Any process that modulates the frequency, rate or extent of signal transduction. - GOC:sm - - - - - - - - - - positive regulation of signal transduction - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of signal transduction. - GO:0009967 - GO:0035468 - Reactome:REACT_6227 - activation of signal transduction - biological_process - positive regulation of signaling pathway - positive regulation of signalling pathway - stimulation of signal transduction - up regulation of signal transduction - up-regulation of signal transduction - upregulation of signal transduction - - - - - GOC:mah - positive regulation of signalling pathway - - - - - Any process that activates or increases the frequency, rate or extent of signal transduction. - GOC:sm - - - - - Activated DTOR also phosphorylates D4EBP, Drosophila melanogaster - Reactome:REACT_6227 - - - - - - - - - - negative regulation of signal transduction - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction. - GO:0009968 - GO:0035467 - Reactome:REACT_6334 - biological_process - down regulation of signal transduction - down-regulation of signal transduction - downregulation of signal transduction - inhibition of signal transduction - negative regulation of signaling pathway - negative regulation of signalling pathway - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction. - GOC:sm - - - - - DTSC1 AND DTSC2 form a complex, Drosophila melanogaster - Reactome:REACT_6334 - - - - - GOC:mah - negative regulation of signalling pathway - - - - - - - - - - cellular process - - - Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. - GO:0008151 - GO:0009987 - GO:0050875 - biological_process - cell growth and/or maintenance - cell physiology - cellular physiological process - - - - - - - Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. - GOC:go_curators - GOC:isa_complete - - - - - - - - - - endomembrane system organization - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system. - GO:0010256 - biological_process - endomembrane organization - endomembrane system organisation - - - - GOC:mah - endomembrane system organisation - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system. - GOC:mah - GOC:sm - - - - - GOC:curators - endomembrane organization - - - - - - - - - - exit from mitosis - - - - - - - - GO:0010458 - The cell cycle transition where a cell leaves M phase and enters a new G1 phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place. - biological_process - mitotic exit - - - - GOC:dph - GOC:tb - The cell cycle transition where a cell leaves M phase and enters a new G1 phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place. - - - - - - - - - - gene expression - - GO:0010467 - Reactome:REACT_100537 - Reactome:REACT_101147 - Reactome:REACT_101952 - Reactome:REACT_105649 - Reactome:REACT_108313 - Reactome:REACT_29068 - Reactome:REACT_34240 - Reactome:REACT_71 - Reactome:REACT_78136 - Reactome:REACT_78959 - Reactome:REACT_79662 - Reactome:REACT_85241 - Reactome:REACT_85359 - Reactome:REACT_86357 - Reactome:REACT_89816 - Reactome:REACT_91657 - Reactome:REACT_91965 - Reactome:REACT_93586 - Reactome:REACT_93968 - Reactome:REACT_94814 - Reactome:REACT_98256 - The process in which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. - Wikipedia:Gene_expression - biological_process - - - - - Gene Expression, Sus scrofa - Reactome:REACT_101952 - - - - - Gene Expression, Rattus norvegicus - Reactome:REACT_91965 - - - - - Gene Expression, Schizosaccharomyces pombe - Reactome:REACT_94814 - - - - - Gene Expression, Escherichia coli - Reactome:REACT_29068 - - - - - Gene Expression, Homo sapiens - Reactome:REACT_71 - - - - - Gene Expression, Caenorhabditis elegans - Reactome:REACT_108313 - - - - - Gene Expression, Mus musculus - Reactome:REACT_78136 - - - - - Gene Expression, Arabidopsis thaliana - Reactome:REACT_91657 - - - - - Gene Expression, Canis familiaris - Reactome:REACT_86357 - - - - - Gene Expression, Oryza sativa - Reactome:REACT_85241 - - - - - Gene Expression, Xenopus tropicalis - Reactome:REACT_100537 - - - - - Gene Expression, Taeniopygia guttata - Reactome:REACT_78959 - - - - - Gene Expression, Mycobacterium tuberculosis - Reactome:REACT_89816 - - - - - Gene Expression, Dictyostelium discoideum - Reactome:REACT_93586 - - - - - Gene Expression, Bos taurus - Reactome:REACT_93968 - - - - - Gene Expression, Staphylococcus aureus N315 - Reactome:REACT_34240 - - - - - Gene Expression, Saccharomyces cerevisiae - Reactome:REACT_98256 - - - - - Gene Expression, Plasmodium falciparum - Reactome:REACT_79662 - - - - - Gene Expression, Drosophila melanogaster - Reactome:REACT_105649 - - - - - Gene Expression, Gallus gallus - Reactome:REACT_85359 - - - - - Gene Expression, Danio rerio - Reactome:REACT_101147 - - - - - GOC:dph - GOC:tb - The process in which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. - - - - - - - - - - regulation of gene expression - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. - GO:0010468 - This class covers any process that regulates the rate of production of a mature gene product, and so includes processes that regulate that rate by regulating the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that regulates the level, stability or availabiliy of mRNA for translation and thereby regulates the rate of production of the encoded protein via translation. - Wikipedia:Regulation_of_gene_expression - biological_process - regulation of gene product expression - regulation of protein expression - - - - - GOC:curators - regulation of gene product expression - - - - - Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. - GOC:dph - GOC:tb - - - - - GOC:curators - regulation of protein expression - - - - - - - - - - regulation of macromolecule biosynthetic process - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - GO:0010556 - biological_process - - - - - Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - GOC:dph - GOC:tb - - - - - - - - - - positive regulation of macromolecule biosynthetic process - - - - - - - - - - - - - - - - - - - - - Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - GO:0010557 - biological_process - - - - Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - GOC:dph - GOC:tb - - - - - - - - - - negative regulation of macromolecule biosynthetic process - - - - - - - - - - - - - - - - - - - - - Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - GO:0010558 - biological_process - - - - Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - GOC:dph - GOC:tb - - - - - - - - - - positive regulation of macromolecule metabolic process - - - - - - - - - - - - - - - - - - - - Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - GO:0010604 - biological_process - - - - Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - GOC:dph - GOC:tb - - - - - - - - - - negative regulation of macromolecule metabolic process - - - - - - - - - - - - - - - - - - - - Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - GO:0010605 - biological_process - - - - Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - GOC:dph - GOC:tb - - - - - - - - - - positive regulation of gene expression - - - - - - - - - - - - - - - - - - - - Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. - GO:0010628 - biological_process - - - - Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. - GOC:dph - GOC:tb - - - - - - - - - - negative regulation of gene expression - - - - - - - - - - - - - - - - - - - - Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. - GO:0010629 - This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availabiliy of mRNA for translation and thereby reduces the rate of production of the encoded protein via translation. - biological_process - - - - Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. - GOC:dph - GOC:tb - - - - - - - - - - regulation of cell communication - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. - GO:0010646 - biological_process - - - - Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. - GOC:dph - GOC:tb - - - - - - - - - - positive regulation of cell communication - - - - - - - - - - - - - - - - - - - - Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. - GO:0010647 - biological_process - - - - Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. - GOC:dph - GOC:tb - - - - - - - - - - negative regulation of cell communication - - - - - - - - - - - - - - - - - - - - Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. - GO:0010648 - biological_process - - - - Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. - GOC:dph - GOC:tb - - - - - - - - - - programmed cell death - - A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell. - GO:0012501 - GO:0016244 - Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. Also, note that 'programmed cell death ; GO:0012501' should be used to refer to instances of caspase-independent cell death mechanisms, in the absence of further indications on the process taking place. At present, caspase-independent cell death is not yet represented in GO due to the lack of consensus and in-depth research on the topic. 'programmed cell death ; GO:0012501' may also be used to annotate gene products in taxa where apoptosis as defined in GO:0006915 does not occur, such as plants. You may also consider these specific children: GO:0097468 'programmed cell death in response to reactive oxygen species' (with descendants GO:0010421 'hydrogen peroxide-mediated programmed cell death' and GO:0010343 'singlet oxygen-mediated programmed cell death'), and GO:0009626 'plant-type hypersensitive response' and its children, which are descendants of GO:0034050 'host programmed cell death induced by symbiont'. - PCD - Wikipedia:Programmed_cell_death - biological_process - caspase-independent apoptosis - caspase-independent cell death - non-apoptotic programmed cell death - nonapoptotic programmed cell death - regulated cell death - - - - A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell. - GOC:lr - GOC:mtg_apoptosis - - - - - - - - - - endomembrane system - - - - - - - - - - - - - - A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. - GO:0012505 - Wikipedia:Endomembrane_system - cellular_component - - - - - - - A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. - GOC:lh - - - - - - - - - - Cajal body - - A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA. - GO:0015030 - Gemini of coiled bodies - Gems - NIF_Subcellular:nlx_subcell_090901 - Wikipedia:Cajal_body - cellular_component - coiled body - - - - A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA. - NIF_Subcellular:nlx_subcell_090901 - PMID:10944589 - PMID:11031238 - PMID:7559785 - - - - - - - - - - protein transport - - - - GO:0015031 - GO:0015831 - The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - biological_process - enzyme transport - - - - - - GOC:ai - The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - - - - - - - - - - actin cytoskeleton - - GO:0015629 - The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. - cellular_component - - - - - GOC:jl - ISBN:0395825172 - ISBN:0815316194 - The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. - - - - - - - - - - microtubule cytoskeleton - - GO:0015630 - The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. - cellular_component - - - - - GOC:jl - ISBN:0395825172 - The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. - - - - - - - - - - peptide transport - - - GO:0015833 - The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - biological_process - - - - - - GOC:ai - The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - - - - - - - - - - membrane - - A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. - GO:0016020 - Wikipedia:Biological_membrane - cellular_component - - - - - - - - - - - - A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. - GOC:dos - GOC:mah - ISBN:0815316194 - - - - - - - - - - cytoplasmic membrane-bounded vesicle - - - - - - - - - - - - - - - - - - - - - A membrane-bounded vesicle found in the cytoplasm of the cell. - GO:0016023 - cellular_component - cytoplasmic membrane bounded vesicle - cytoplasmic membrane-enclosed vesicle - - - - - - - - - - A membrane-bounded vesicle found in the cytoplasm of the cell. - GOC:ai - GOC:mah - - - - - - - - - - cellular component organization - - - A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. - GO:0016043 - GO:0044235 - GO:0071842 - biological_process - cell organisation - cell organization and biogenesis - cellular component organisation at cellular level - cellular component organisation in other organism - cellular component organization at cellular level - cellular component organization in other organism - - - - - - - - A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. - GOC:ai - GOC:jl - GOC:mah - - - - - GOC:mah - cellular component organisation in other organism - - - - - GOC:mah - cell organization and biogenesis - - - - - GOC:mah - cellular component organisation at cellular level - - - - - - - - - - cell growth - - - GO:0016049 - GO:0048591 - The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. - biological_process - cell expansion - cellular growth - growth of cell - metabolic process resulting in cell growth - metabolism resulting in cell growth - non-developmental cell growth - non-developmental growth of a unicellular organism - - - - - - - - GOC:mah - non-developmental growth of a unicellular organism - - - - - GOC:mah - non-developmental cell growth - - - - - GOC:ai - The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. - - - - - - - - - - RNA metabolic process - - - GO:0016070 - RNA metabolism - Reactome:REACT_107259 - Reactome:REACT_107652 - Reactome:REACT_110289 - Reactome:REACT_21257 - Reactome:REACT_30579 - Reactome:REACT_31367 - Reactome:REACT_33720 - Reactome:REACT_80071 - Reactome:REACT_83630 - Reactome:REACT_84169 - Reactome:REACT_85788 - Reactome:REACT_88316 - Reactome:REACT_89992 - Reactome:REACT_91556 - Reactome:REACT_92152 - Reactome:REACT_94876 - Reactome:REACT_99403 - Reactome:REACT_99885 - The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. - biological_process - - - - - - - - - Metabolism of RNA, Caenorhabditis elegans - Reactome:REACT_80071 - - - - - Metabolism of RNA, Sus scrofa - Reactome:REACT_107259 - - - - - Metabolism of RNA, Bos taurus - Reactome:REACT_91556 - - - - - Metabolism of RNA, Schizosaccharomyces pombe - Reactome:REACT_107652 - - - - - Metabolism of RNA, Danio rerio - Reactome:REACT_110289 - - - - - Metabolism of RNA, Mus musculus - Reactome:REACT_88316 - - - - - Metabolism of RNA, Arabidopsis thaliana - Reactome:REACT_94876 - - - - - Metabolism of RNA, Xenopus tropicalis - Reactome:REACT_30579 - - - - - Metabolism of RNA, Gallus gallus - Reactome:REACT_99885 - - - - - Metabolism of RNA, Saccharomyces cerevisiae - Reactome:REACT_89992 - - - - - Metabolism of RNA, Homo sapiens - Reactome:REACT_21257 - - - - - Metabolism of RNA, Dictyostelium discoideum - Reactome:REACT_31367 - - - - - Metabolism of RNA, Taeniopygia guttata - Reactome:REACT_83630 - - - - - Metabolism of RNA, Rattus norvegicus - Reactome:REACT_99403 - - - - - Metabolism of RNA, Drosophila melanogaster - Reactome:REACT_92152 - - - - - Metabolism of RNA, Plasmodium falciparum - Reactome:REACT_33720 - - - - - Metabolism of RNA, Canis familiaris - Reactome:REACT_84169 - - - - - Metabolism of RNA, Oryza sativa - Reactome:REACT_85788 - - - - - ISBN:0198506732 - The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. - - - - - - - - - - death - - A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism. - GO:0016265 - This term should not be used for direct manual annotation. Instead, consider selecting a child term of GO:0008219 'cell death' or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - Wikipedia:Death - biological_process - - - - - - - A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism. - GOC:mah - GOC:mtg_apoptosis - ISBN:0877797099 - - - - - - - - - - cell migration - - GO:0016477 - The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms. - Wikipedia:Cell_migration - biological_process - - - - GOC:cjm - GOC:dph - GOC:ems - GOC:pf - The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms. - http://en.wikipedia.org/wiki/Cell_migration - - - - - - - - - - cytoplasmic transport - - - - - - - - GO:0016482 - The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, or within the cytoplasm of a cell. - biological_process - cytoplasmic streaming - - - - GOC:ai - The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, or within the cytoplasm of a cell. - - - - - - - - - - nuclear body - - Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. - GO:0016604 - NIF_Subcellular:sao505137457 - cellular_component - - - - Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. - GOC:ma - PMID:10330182 - - - - - - - - - - PML body - - A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection. - GO:0016605 - ND10 - PML NB - PML nuclear body - cellular_component - nuclear dot - - - - A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection. - GOC:ma - PMID:10944585 - - - - - - - - - - nuclear speck - - A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. - GO:0016607 - cellular_component - nuclear speckle - nuclear speckles - speckle domain - speckle focus - splicing speckle - - - - A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. - http://www.cellnucleus.com/ - - - - - - - - - - transferase activity - - Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. - EC:2 - GO:0016740 - Reactome:REACT_25050 - molecular_function - - - - - - - - - - - - Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. - ISBN:0198506732 - - - - - Molybdenum ion transfer onto molybdopterin, Homo sapiens - Reactome:REACT_25050 - - - - - - - - - - transferase activity, transferring phosphorus-containing groups - - Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). - EC:2.7 - GO:0016772 - Note that this term encompasses all kinase activities, as well as activities that transfer other phosphorus-containing groups such as diphosphate or nucleotides. - molecular_function - - - - - - Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). - GOC:jl - ISBN:0198506732 - - - - - - - - - - nucleotidyltransferase activity - - Catalysis of the transfer of a nucleotidyl group to a reactant. - EC:2.7.7 - GO:0016779 - molecular_function - - - - - - - - - - Catalysis of the transfer of a nucleotidyl group to a reactant. - ISBN:0198506732 - - - - - - - - - - hydrolase activity - - Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. - EC:3 - GO:0016787 - Reactome:REACT_110436 - Reactome:REACT_111159 - Reactome:REACT_15331 - Reactome:REACT_83734 - Reactome:REACT_84047 - Reactome:REACT_87959 - Reactome:REACT_88159 - Reactome:REACT_90118 - Reactome:REACT_91045 - Reactome:REACT_98572 - molecular_function - - - - - - - - - - - - Hydrolysis of phosphatidylcholine, Bos taurus - Reactome:REACT_110436 - - - - - Hydrolysis of phosphatidylcholine, Xenopus tropicalis - Reactome:REACT_84047 - - - - - Hydrolysis of phosphatidylcholine, Rattus norvegicus - Reactome:REACT_98572 - - - - - Hydrolysis of phosphatidylcholine, Gallus gallus - Reactome:REACT_87959 - - - - - Hydrolysis of phosphatidylcholine, Canis familiaris - Reactome:REACT_88159 - - - - - Hydrolysis of phosphatidylcholine, Homo sapiens - Reactome:REACT_15331 - - - - - Hydrolysis of phosphatidylcholine, Mus musculus - Reactome:REACT_90118 - - - - - Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. - ISBN:0198506732 - - - - - Partial proteolysis of antigen in phagolysosomes, Homo sapiens - Reactome:REACT_111159 - - - - - Hydrolysis of phosphatidylcholine, Danio rerio - Reactome:REACT_83734 - - - - - Hydrolysis of phosphatidylcholine, Taeniopygia guttata - Reactome:REACT_91045 - - - - - - - - - - hydrolase activity, acting on ester bonds - - Catalysis of the hydrolysis of any ester bond. - EC:3.1 - GO:0016788 - Reactome:REACT_106563 - Reactome:REACT_109748 - Reactome:REACT_112177 - Reactome:REACT_19294 - Reactome:REACT_1978 - Reactome:REACT_45174 - Reactome:REACT_77112 - Reactome:REACT_81282 - Reactome:REACT_83347 - Reactome:REACT_88228 - Reactome:REACT_88314 - Reactome:REACT_89615 - Reactome:REACT_92446 - Reactome:REACT_94475 - esterase activity - molecular_function - - - - - - - Deacylation of Acyl Ghrelin, Gallus gallus - Reactome:REACT_83347 - - - - - Deacylation of Acyl Ghrelin, Homo sapiens - Reactome:REACT_19294 - - - - - Deacylation of Acyl Ghrelin, Bos taurus - Reactome:REACT_109748 - - - - - uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid, Homo sapiens - Reactome:REACT_1978 - - - - - uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid, Bos taurus - Reactome:REACT_94475 - - - - - uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid, Danio rerio - Reactome:REACT_77112 - - - - - uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid, Canis familiaris - Reactome:REACT_92446 - - - - - uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid, Xenopus tropicalis - Reactome:REACT_112177 - - - - - Catalysis of the hydrolysis of any ester bond. - GOC:jl - - - - - Deacylation of Acyl Ghrelin, Mus musculus - Reactome:REACT_106563 - - - - - Deacylation of Acyl Ghrelin, Canis familiaris - Reactome:REACT_88228 - - - - - uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid, Mus musculus - Reactome:REACT_45174 - - - - - uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid, Rattus norvegicus - Reactome:REACT_89615 - - - - - Deacylation of Acyl Ghrelin, Rattus norvegicus - Reactome:REACT_81282 - - - - - uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid, Sus scrofa - Reactome:REACT_88314 - - - - - - - - - - protein import - - - GO:0017038 - The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event. - biological_process - protein uptake - - - - - GOC:ai - The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event. - - - - - - - - - - heterocycle biosynthetic process - - - GO:0018130 - The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). - biological_process - heterocycle anabolism - heterocycle biosynthesis - heterocycle formation - heterocycle synthesis - - - - - ISBN:0198547684 - The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). - - - - - - - - - - regulation of nucleobase-containing compound metabolic process - - - - - - - - - - - - - - - - - - - - - Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. - GO:0019219 - biological_process - regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process - regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism - - - - - Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. - GOC:go_curators - - - - - GOC:dph - GOC:tb - regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process - - - - - - - - - - regulation of metabolic process - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. - GO:0019222 - biological_process - regulation of metabolism - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. - GOC:go_curators - - - - - - - - - - aromatic compound biosynthetic process - - - GO:0019438 - The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring. - aromatic compound anabolism - aromatic compound biosynthesis - aromatic compound formation - aromatic compound synthesis - aromatic hydrocarbon biosynthesis - aromatic hydrocarbon biosynthetic process - biological_process - - - - - GOC:ai - The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring. - - - - - - - - - - aromatic compound catabolic process - - - GO:0019439 - The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring. - aromatic compound breakdown - aromatic compound catabolism - aromatic compound degradation - aromatic hydrocarbon catabolic process - aromatic hydrocarbon catabolism - biological_process - - - - - GOC:ai - The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring. - - - - - - - - - - cell cycle process - - - - - - - - - - - - - - - - - - - GO:0022402 - The cellular process that ensures successive accurate and complete genome replication and chromosome segregation. - biological_process - - - - - - GOC:isa_complete - GOC:mtg_cell_cycle - The cellular process that ensures successive accurate and complete genome replication and chromosome segregation. - - - - - - - - - - cell cycle phase - - GO:0022403 - One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events. - biological_process - - - - - GOC:mtg_cell_cycle - One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events. - - - - - - - - - - cellular component disassembly - - - A cellular process that results in the breakdown of a cellular component. - GO:0022411 - GO:0071845 - biological_process - cell structure disassembly - cellular component disassembly at cellular level - - - - - - A cellular process that results in the breakdown of a cellular component. - GOC:isa_complete - - - - - - - - - - cellular component assembly - - - - - - - - GO:0022607 - GO:0071844 - The aggregation, arrangement and bonding together of a cellular component. - biological_process - cell structure assembly - cellular component assembly at cellular level - - - - - - - - GOC:isa_complete - The aggregation, arrangement and bonding together of a cellular component. - - - - - - - - - - biological adhesion - - - GO:0022610 - The attachment of a cell or organism to a substrate or other organism. - biological_process - - - - - - GOC:isa_complete - The attachment of a cell or organism to a substrate or other organism. - - - - - - - - - - regulation of signaling - - - - - - - - - - - - - - - - - - - 2010-02-16T09:30:50Z - Any process that modulates the frequency, rate or extent of a signaling process. - GO:0023051 - biological_process - regulation of signaling process - regulation of signalling process - - - - GOC:mah - regulation of signalling process - - - - - Any process that modulates the frequency, rate or extent of a signaling process. - GOC:mtg_signal - - - - - GOC:bf - regulation of signaling process - - - - - - - - - - signaling - - - 2010-02-16T09:30:50Z - GO:0023046 - GO:0023052 - Note that a signal is any variable property or parameter that serves to convey information, and may be a physical entity such as a gene product or small molecule, a photon, or a change in state such as movement or voltage change. - The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered. - biological signaling - biological_process - signaling process - signalling - signalling process - - - - - - GOC:mtg_signal - GOC:mtg_signaling_feb11 - GOC:signaling - The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered. - - - - - GOC:mah - signalling process - - - - - - - - - - positive regulation of signaling - - - - - - - - - - - - - - - - - - - - - - - - - - 2010-02-16T09:30:50Z - Any process that activates, maintains or increases the frequency, rate or extent of a signaling process. - GO:0023056 - biological_process - positive regulation of signaling process - positive regulation of signalling process - - - - GOC:bf - positive regulation of signaling process - - - - - Any process that activates, maintains or increases the frequency, rate or extent of a signaling process. - GOC:mtg_signal - - - - - GOC:mah - positive regulation of signalling process - - - - - - - - - - negative regulation of signaling - - - - - - - - - - - - - - - - - - - - - - - - - - 2010-02-16T09:30:50Z - Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process. - GO:0023057 - biological_process - negative regulation of signaling process - negative regulation of signalling process - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process. - GOC:mtg_signal - - - - - GOC:mah - negative regulation of signalling process - - - - - GOC:bf - negative regulation of signaling process - - - - - - - - - - lamellipodium - - - - - - - - A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments. - GO:0030027 - Wikipedia:Lamellipodia - cellular_component - - - - A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments. - ISBN:0815316194 - - - - - - - - - - actin filament-based process - - Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins. - GO:0030029 - biological_process - microfilament-based process - - - - Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins. - GOC:mah - - - - - - - - - - cell projection organization - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon. - GO:0030030 - biological_process - cell projection organisation - cell projection organization and biogenesis - cell surface structure organization and biogenesis - - - - - GOC:mah - cell surface structure organization and biogenesis - - - - - GOC:curators - cell projection organisation - - - - - GOC:mah - cell projection organization and biogenesis - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon. - GOC:jl - GOC:mah - http://www.cogsci.princeton.edu/~wn/ - - - - - - - - - - cell projection assembly - - - Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon. - GO:0030031 - biological_process - cell projection biogenesis - formation of a cell surface projection - - - - - - Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon. - GOC:jl - GOC:mah - http://www.cogsci.princeton.edu/~wn/ - - - - - GOC:mah - cell projection biogenesis - - - - - - - - - - actin filament-based movement - - - GO:0030048 - Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins. - biological_process - - - - GOC:BHF - GOC:mah - Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins. - - - - - - - - - - cell junction - - A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix. - GO:0030054 - Wikipedia:Cell_junction - cellular_component - - - - A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix. - GOC:mah - ISBN:0198506732 - http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html - - - - - - - - - - cell-substrate junction - - A cell junction that forms a connection between a cell and the extracellular matrix. - GO:0030055 - cell-matrix junction - cellular_component - - - - A cell junction that forms a connection between a cell and the extracellular matrix. - GOC:hb - GOC:mah - - - - - - - - - - endocytic vesicle - - A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting. - GO:0030139 - NIF_Subcellular:sao1362520468 - cellular_component - endocytotic transport vesicle - endocytotic vesicle - - - - - A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting. - GOC:go_curators - PMID:19696797 - - - - - - - - - - cell differentiation - - GO:0030154 - The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. - Wikipedia:Cellular_differentiation - biological_process - - - - - - - - ISBN:0198506732 - The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. - - - - - - - - - - filopodium - - A filopodium may be approximately 0.1 um wide, 5-10 um long, and up to 50 um long in axon growth cones; may contain a loose bundle of about 20 actin filaments oriented with their plus ends pointing outward. Note that filopodia on dendritic shafts are distinct from other types of filopodia (even those found in dendritic growth cones) and may react differently to stimuli, as shown in PMID:12904473. - GO:0030028 - GO:0030175 - NIF_Subcellular:sao-1046371754 - Thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft. - Wikipedia:Filopodia - cellular_component - - - - - GOC:mah - GOC:pr - ISBN:0815316194 - Thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft. - - - - - - - - - - chromosome condensation - - - DNA condensation - GO:0000068 - GO:0030261 - The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells. - biological_process - eukaryotic chromosome condensation - nuclear chromosome condensation - - - - DNA condensation - Wikipedia:DNA_condensation - - - - - GOC:bf - eukaryotic chromosome condensation - - - - - GOC:bf - nuclear chromosome condensation - - - - - GOC:mah - ISBN:0815316194 - The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells. - - - - - - - - - - apoptotic nuclear changes - - Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis. - GO:0030262 - apoptotic nuclear change - biological_process - - - - Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis. - GOC:mah - GOC:mtg_apoptosis - - - - - - - - - - axon - - GO:0030424 - NIF_Subcellular:sao1770195789 - The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. - Wikipedia:Axon - cellular_component - - - - GOC:nln - ISBN:0198506732 - The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. - - - - - - - - - - dendrite - - - - - - - - A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. - GO:0030425 - NIF_Subcellular:sao1211023249 - Wikipedia:Dendrite - cellular_component - - - - A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. - GOC:dos - GOC:mah - GOC:nln - ISBN:0198506732 - - - - - - - - - - cortical cytoskeleton - - - GO:0030863 - The portion of the cytoskeleton that lies just beneath the plasma membrane. - cellular_component - - - - GOC:mah - The portion of the cytoskeleton that lies just beneath the plasma membrane. - - - - - - - - - - cortical actin cytoskeleton - - - - - - - - - - - - - - - - - - - - GO:0030864 - The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane. - cellular_component - - - - GOC:mah - The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane. - - - - - - - - - - intraciliary transport particle - - A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules. - GO:0030990 - IFT complex - Note that we deem cilia and microtubule-based flagella to be equivalent. - cellular_component - intraflagellar transport complex - intraflagellar transport particle - - - - - A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules. - GOC:cilia - GOC:kmv - PMID:14570576 - PMID:22118932 - PMID:23945166 - - - - - - - - - - microtubule organizing center organization - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow. - GO:0031023 - biological_process - microtubule organising center organisation - microtubule organizing center organization and biogenesis - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow. - GOC:dph - GOC:jl - GOC:mah - - - - - GOC:curators - microtubule organising center organisation - - - - - GOC:mah - microtubule organizing center organization and biogenesis - - - - - - - - - - micronucleus - - A membrane-bounded organelle of ciliated protozoan cells that contains a diploid copy of the cell's complete genome. Sections of contiguous sequence in the macronucleus are often interrupted by internal eliminated sequences (IES), and may be permuted, in micronuclei. Genic transcription is not found in micronuclei. Some ciliate species may contain multiple micronuclei per cell. - GO:0031040 - Wikipedia:Micronucleus - cellular_component - - - - A membrane-bounded organelle of ciliated protozoan cells that contains a diploid copy of the cell's complete genome. Sections of contiguous sequence in the macronucleus are often interrupted by internal eliminated sequences (IES), and may be permuted, in micronuclei. Genic transcription is not found in micronuclei. Some ciliate species may contain multiple micronuclei per cell. - GOC:ns - - - - - - - - - - cell leading edge - - GO:0031252 - The area of a motile cell closest to the direction of movement. - cellular_component - front of cell - leading edge of cell - - - - - GOC:pg - The area of a motile cell closest to the direction of movement. - - - - - - - - - - regulation of cellular metabolic process - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. - GO:0031323 - biological_process - regulation of cellular metabolism - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. - GOC:mah - - - - - - - - - - negative regulation of cellular metabolic process - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. - GO:0031324 - biological_process - down regulation of cellular metabolic process - down-regulation of cellular metabolic process - downregulation of cellular metabolic process - inhibition of cellular metabolic process - negative regulation of cellular metabolism - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. - GOC:mah - - - - - - - - - - positive regulation of cellular metabolic process - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. - GO:0031325 - Reactome:REACT_101225 - Reactome:REACT_102187 - Reactome:REACT_102331 - Reactome:REACT_105293 - Reactome:REACT_108571 - Reactome:REACT_109170 - Reactome:REACT_2122 - Reactome:REACT_28360 - Reactome:REACT_31270 - Reactome:REACT_79603 - Reactome:REACT_80902 - Reactome:REACT_83058 - Reactome:REACT_84314 - Reactome:REACT_86633 - Reactome:REACT_87840 - Reactome:REACT_88060 - Reactome:REACT_91293 - Reactome:REACT_91429 - Reactome:REACT_91906 - Reactome:REACT_92487 - Reactome:REACT_99393 - activation of cellular metabolic process - biological_process - positive regulation of cellular metabolism - stimulation of cellular metabolic process - up regulation of cellular metabolic process - up-regulation of cellular metabolic process - upregulation of cellular metabolic process - - - - - ChREBP activates metabolic gene expression, Caenorhabditis elegans - Reactome:REACT_102331 - - - - - ChREBP activates metabolic gene expression, Sus scrofa - Reactome:REACT_99393 - - - - - ChREBP activates metabolic gene expression, Escherichia coli - Reactome:REACT_102187 - - - - - ChREBP activates metabolic gene expression, Xenopus tropicalis - Reactome:REACT_109170 - - - - - ChREBP activates metabolic gene expression, Danio rerio - Reactome:REACT_87840 - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. - GOC:mah - - - - - ChREBP activates metabolic gene expression, Oryza sativa - Reactome:REACT_84314 - - - - - ChREBP activates metabolic gene expression, Rattus norvegicus - Reactome:REACT_88060 - - - - - ChREBP activates metabolic gene expression, Staphylococcus aureus N315 - Reactome:REACT_91293 - - - - - ChREBP activates metabolic gene expression, Schizosaccharomyces pombe - Reactome:REACT_91906 - - - - - ChREBP activates metabolic gene expression, Arabidopsis thaliana - Reactome:REACT_28360 - - - - - ChREBP activates metabolic gene expression, Plasmodium falciparum - Reactome:REACT_105293 - - - - - ChREBP activates metabolic gene expression, Gallus gallus - Reactome:REACT_91429 - - - - - ChREBP activates metabolic gene expression, Taeniopygia guttata - Reactome:REACT_83058 - - - - - ChREBP activates metabolic gene expression, Drosophila melanogaster - Reactome:REACT_108571 - - - - - ChREBP activates metabolic gene expression, Homo sapiens - Reactome:REACT_2122 - - - - - ChREBP activates metabolic gene expression, Canis familiaris - Reactome:REACT_79603 - - - - - ChREBP activates metabolic gene expression, Mycobacterium tuberculosis - Reactome:REACT_31270 - - - - - ChREBP activates metabolic gene expression, Saccharomyces cerevisiae - Reactome:REACT_80902 - - - - - ChREBP activates metabolic gene expression, Bos taurus - Reactome:REACT_92487 - - - - - ChREBP activates metabolic gene expression, Mus musculus - Reactome:REACT_101225 - - - - - ChREBP activates metabolic gene expression, Dictyostelium discoideum - Reactome:REACT_86633 - - - - - - - - - - regulation of cellular biosynthetic process - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. - GO:0031326 - biological_process - regulation of cellular anabolism - regulation of cellular biosynthesis - regulation of cellular formation - regulation of cellular synthesis - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. - GOC:mah - - - - - - - - - - negative regulation of cellular biosynthetic process - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. - GO:0031327 - biological_process - down regulation of cellular biosynthetic process - down-regulation of cellular biosynthetic process - downregulation of cellular biosynthetic process - inhibition of cellular biosynthetic process - negative regulation of cellular anabolism - negative regulation of cellular biosynthesis - negative regulation of cellular formation - negative regulation of cellular synthesis - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. - GOC:mah - - - - - - - - - - positive regulation of cellular biosynthetic process - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. - GO:0031328 - activation of cellular biosynthetic process - biological_process - positive regulation of cellular anabolism - positive regulation of cellular biosynthesis - positive regulation of cellular formation - positive regulation of cellular synthesis - stimulation of cellular biosynthetic process - up regulation of cellular biosynthetic process - up-regulation of cellular biosynthetic process - upregulation of cellular biosynthetic process - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. - GOC:mah - - - - - - - - - - cytoplasmic vesicle - - - - - - - - - - - - - - - - - - - - - A vesicle formed of membrane or protein, found in the cytoplasm of a cell. - GO:0031410 - NIF_Subcellular:sao180601769 - cellular_component - - - - - A vesicle formed of membrane or protein, found in the cytoplasm of a cell. - GOC:mah - - - - - - - - - - protein complex localization - - A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location. - GO:0031503 - biological_process - establishment and maintenance of protein complex localization - protein complex localisation - - - - - GOC:mah - protein complex localisation - - - - - A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location. - GOC:mah - - - - - - - - - - PcG protein complex - - - A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure. - GO:0031519 - Polycomb Group protein complex - cellular_component - - - - - A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure. - PMID:9372908 - - - - - - - - - - cell-substrate adhesion - - GO:0031589 - The attachment of a cell to the underlying substrate via adhesion molecules. - biological_process - - - - - GOC:mah - GOC:pf - The attachment of a cell to the underlying substrate via adhesion molecules. - - - - - - - - - - membrane-enclosed lumen - - GO:0031974 - The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen. - cellular_component - - - - GOC:add - GOC:mah - The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen. - - - - - - - - - - nuclear lumen - - - GO:0031981 - The volume enclosed by the nuclear inner membrane. - cellular_component - - - - GOC:mah - GOC:pz - The volume enclosed by the nuclear inner membrane. - - - - - - - - - - vesicle - - Any small, fluid-filled, spherical organelle enclosed by membrane or protein. - GO:0031982 - NIF_Subcellular:sao221389602 - Wikipedia:Vesicle_(biology) - cellular_component - - - - - - - Any small, fluid-filled, spherical organelle enclosed by membrane or protein. - GOC:mah - GOC:pz - - - - - - - - - - membrane-bounded vesicle - - - Any small, fluid-filled, spherical organelle enclosed by a lipid bilayer. - GO:0031988 - cellular_component - membrane-enclosed vesicle - - - - - Any small, fluid-filled, spherical organelle enclosed by a lipid bilayer. - GOC:mah - - - - - - - - - - bleb assembly - - GO:0032060 - The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses. - biological_process - blebbing - cell blebbing - membrane blebbing - plasma membrane bleb assembly - plasma membrane blebbing - - - - GOC:pr - membrane blebbing - - - - - GOC:pr - blebbing - - - - - GOC:pr - plasma membrane blebbing - - - - - GOC:mah - GOC:mtg_apoptosis - PMID:12083798 - PMID:16624291 - The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses. - http://en.wikipedia.org/wiki/Bleb_(cell_biology) - - - - - GOC:pr - plasma membrane bleb assembly - - - - - - - - - - negative regulation of NF-kappaB transcription factor activity - - Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB. - GO:0032088 - NF-kappaB inhibitor - biological_process - inhibition of NF-kappaB transcription factor - - - - GOC:dph - GOC:tb - inhibition of NF-kappaB transcription factor - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB. - GOC:dph - GOC:rl - GOC:tb - - - - - - - - - - regulation of intracellular transport - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the directed movement of substances within cells. - GO:0032386 - biological_process - - - - Any process that modulates the frequency, rate or extent of the directed movement of substances within cells. - GOC:mah - - - - - - - - - - negative regulation of intracellular transport - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells. - GO:0032387 - biological_process - down regulation of intracellular transport - down-regulation of intracellular transport - downregulation of intracellular transport - inhibition of intracellular transport - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells. - GOC:mah - - - - - - - - - - positive regulation of intracellular transport - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells. - GO:0032388 - activation of intracellular transport - biological_process - stimulation of intracellular transport - up regulation of intracellular transport - up-regulation of intracellular transport - upregulation of intracellular transport - - - - Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells. - GOC:mah - - - - - - - - - - actin filament bundle - - - - - - - - - - - - - - An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. - GO:0000141 - GO:0030482 - GO:0032432 - actin cable - cellular_component - - - - An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. - GOC:mah - - - - - GOC:mah - actin cable - - - - - - - - - - developmental process - - - A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition. - GO:0032502 - biological_process - development - - - - - - - A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition. - GOC:isa_complete - - - - - - - - - - maintenance of protein location in cell - - - - - - - - - - - - - - - - - - - - - - - - - - Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere. - GO:0032507 - biological_process - maintenance of protein localization in cell - - - - GOC:dph - GOC:tb - maintenance of protein localization in cell - - - - - Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere. - GOC:isa_complete - GOC:mah - - - - - - - - - - RNA biosynthetic process - - - - GO:0032774 - Note that, in some cases, viral RNA replication and viral transcription from RNA actually refer to the same process, but may be called differently depending on the focus of a specific research study. - RNA anabolism - RNA biosynthesis - RNA formation - RNA synthesis - The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication. - biological_process - - - - GOC:mah - GOC:txnOH - The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication. - - - - - - - - - - regulation of localization - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location. - GO:0032879 - biological_process - regulation of localisation - - - - - Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location. - GOC:mah - - - - - GOC:mah - regulation of localisation - - - - - - - - - - regulation of protein localization - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location. - GO:0032880 - biological_process - regulation of protein localisation - - - - - - GOC:mah - regulation of protein localisation - - - - - Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location. - GOC:dph - GOC:mah - GOC:tb - - - - - - - - - - secretion by cell - - - - GO:0032940 - The controlled release of a substance by a cell. - Wikipedia:Secretion - biological_process - cellular secretion - - - - GOC:mah - The controlled release of a substance by a cell. - - - - - - - - - - cellular component morphogenesis - - - - GO:0032989 - The process in which cellular structures, including whole cells or cell parts, are generated and organized. - biological_process - cellular structure morphogenesis - - - - - - GOC:dph - GOC:tb - cellular structure morphogenesis - - - - - GOC:dph - GOC:mah - GOC:tb - The process in which cellular structures, including whole cells or cell parts, are generated and organized. - - - - - - - - - - macromolecular complex - - A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together. - GO:0032991 - cellular_component - macromolecule complex - - - - - - A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together. - GOC:mah - - - - - - - - - - macromolecule localization - - Any process in which a macromolecule is transported to, or maintained in, a specific location. - GO:0033036 - biological_process - macromolecule localisation - - - - - Any process in which a macromolecule is transported to, or maintained in, a specific location. - GOC:mah - - - - - GOC:mah - macromolecule localisation - - - - - - - - - - regulation of intracellular protein transport - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells. - GO:0033157 - biological_process - - - - Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells. - GOC:mah - - - - - - - - - - protein localization to organelle - - A process in which a protein is transported to, or maintained in, a location within an organelle. - GO:0033365 - biological_process - protein localisation to organelle - protein localization in organelle - - - - GOC:mah - protein localisation to organelle - - - - - A process in which a protein is transported to, or maintained in, a location within an organelle. - GOC:mah - - - - - GOC:mah - protein localization in organelle - - - - - - - - - - cellular response to stress - - - Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). - GO:0033554 - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - biological_process - - - - - Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). - GOC:mah - - - - - - - - - - DNA polymerase activity - - - - - - - - Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and a 3'hydroxyl group. - DNA nucleotidyltransferase activity - GO:0034061 - Reactome:REACT_115680 - Reactome:REACT_115778 - Reactome:REACT_115899 - Reactome:REACT_115932 - Reactome:REACT_116106 - Reactome:REACT_116167 - deoxynucleate polymerase activity - deoxyribonucleate nucleotidyltransferase activity - deoxyribonucleic acid polymerase activity - deoxyribonucleic polymerase activity - molecular_function - - - - - - EC:2.7.7.7 - deoxyribonucleic polymerase activity - - - - - Elongation by Pol kappa, Gallus gallus - Reactome:REACT_115899 - - - - - Insertion of correct bases opposite to the lesion by Pol eta, Gallus gallus - Reactome:REACT_115932 - - - - - EC:2.7.7.7 - deoxyribonucleate nucleotidyltransferase activity - - - - - DNA nucleotidyltransferase activity - EC:2.7.7.7 - - - - - Elongation by Pol eta, Gallus gallus - Reactome:REACT_116167 - - - - - Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and a 3'hydroxyl group. - EC:2.7.7.7 - GOC:mah - - - - - Repair of ~27-30 bp long patch by DNA Pol Epsilon, Gallus gallus - Reactome:REACT_116106 - - - - - EC:2.7.7.7 - deoxynucleate polymerase activity - - - - - EC:2.7.7.7 - deoxyribonucleic acid polymerase activity - - - - - Insertion of correct bases opposite to the lesion by Pol kappa, Gallus gallus - Reactome:REACT_115680 - - - - - Elongation by Pol zeta complex, Gallus gallus - Reactome:REACT_115778 - - - - - - - - - - protein localization to Golgi apparatus - - A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus. - GO:0034067 - biological_process - protein localisation in Golgi apparatus - protein localization in Golgi apparatus - - - - GOC:curators - protein localization in Golgi apparatus - - - - - GOC:mah - protein localisation in Golgi apparatus - - - - - A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus. - GOC:mah - - - - - - - - - - substrate adhesion-dependent cell spreading - - - - GO:0034446 - The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate. - biological_process - cell spreading during cell substrate adhesion - substrate adhesion dependent cell spreading - - - - GOC:mah - GOC:pf - PMID:17050732 - The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate. - - - - - - - - - - protein localization to nucleus - - A process in which a protein is transported to, or maintained in, a location within the nucleus. - GO:0034504 - biological_process - protein localisation to nucleus - protein localization in cell nucleus - protein localization in nucleus - - - - GOC:mah - protein localisation to nucleus - - - - - A process in which a protein is transported to, or maintained in, a location within the nucleus. - GOC:ecd - - - - - GOC:mah - protein localization in nucleus - - - - - - - - - - cellular protein localization - - - Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. - GO:0016249 - GO:0034613 - biological_process - cellular protein localisation - channel localizer activity - - - - GOC:mah - cellular protein localisation - - - - - GOC:mah - channel localizer activity - - - - - Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. - GOC:mah - - - - - - - - - - cellular nitrogen compound metabolic process - - - GO:0034641 - Reactome:REACT_102000 - Reactome:REACT_103710 - Reactome:REACT_107293 - Reactome:REACT_108179 - Reactome:REACT_109042 - Reactome:REACT_13 - Reactome:REACT_28699 - Reactome:REACT_29108 - Reactome:REACT_32429 - Reactome:REACT_33347 - Reactome:REACT_34326 - Reactome:REACT_55564 - Reactome:REACT_77741 - Reactome:REACT_82379 - Reactome:REACT_86268 - Reactome:REACT_90299 - Reactome:REACT_91959 - Reactome:REACT_93580 - Reactome:REACT_95666 - Reactome:REACT_98086 - Reactome:REACT_99241 - The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells. - biological_process - cellular nitrogen compound metabolism - - - - - - - Metabolism of amino acids and derivatives, Drosophila melanogaster - Reactome:REACT_86268 - - - - - Metabolism of amino acids and derivatives, Escherichia coli - Reactome:REACT_103710 - - - - - Metabolism of amino acids and derivatives, Mus musculus - Reactome:REACT_33347 - - - - - Metabolism of amino acids and derivatives, Saccharomyces cerevisiae - Reactome:REACT_28699 - - - - - Metabolism of amino acids and derivatives, Gallus gallus - Reactome:REACT_55564 - - - - - Metabolism of amino acids and derivatives, Dictyostelium discoideum - Reactome:REACT_98086 - - - - - Metabolism of amino acids and derivatives, Canis familiaris - Reactome:REACT_95666 - - - - - Metabolism of amino acids and derivatives, Staphylococcus aureus N315 - Reactome:REACT_34326 - - - - - Metabolism of amino acids and derivatives, Sus scrofa - Reactome:REACT_109042 - - - - - Metabolism of amino acids and derivatives, Arabidopsis thaliana - Reactome:REACT_107293 - - - - - Metabolism of amino acids and derivatives, Oryza sativa - Reactome:REACT_90299 - - - - - Metabolism of amino acids and derivatives, Bos taurus - Reactome:REACT_82379 - - - - - Metabolism of amino acids and derivatives, Xenopus tropicalis - Reactome:REACT_108179 - - - - - Metabolism of amino acids and derivatives, Homo sapiens - Reactome:REACT_13 - - - - - Metabolism of amino acids and derivatives, Caenorhabditis elegans - Reactome:REACT_29108 - - - - - Metabolism of amino acids and derivatives, Taeniopygia guttata - Reactome:REACT_77741 - - - - - Metabolism of amino acids and derivatives, Danio rerio - Reactome:REACT_93580 - - - - - GOC:mah - The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells. - - - - - Metabolism of amino acids and derivatives, Schizosaccharomyces pombe - Reactome:REACT_99241 - - - - - Metabolism of amino acids and derivatives, Rattus norvegicus - Reactome:REACT_32429 - - - - - Metabolism of amino acids and derivatives, Plasmodium falciparum - Reactome:REACT_91959 - - - - - Metabolism of amino acids and derivatives, Mycobacterium tuberculosis - Reactome:REACT_102000 - - - - - - - - - - cellular macromolecule biosynthetic process - - - - GO:0034645 - GO:0034961 - The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells. - biological_process - cellular biopolymer biosynthetic process - cellular macromolecule anabolism - cellular macromolecule biosynthesis - cellular macromolecule formation - cellular macromolecule synthesis - - - - GOC:mtg_chebi_dec09 - cellular biopolymer biosynthetic process - - - - - GOC:mah - cellular macromolecule synthesis - - - - - GOC:mah - cellular macromolecule biosynthesis - - - - - CHEBI:33694 - GOC:mah - The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells. - - - - - GOC:mah - cellular macromolecule formation - - - - - GOC:mah - cellular macromolecule anabolism - - - - - - - - - - nucleobase-containing compound biosynthetic process - - - - - - GO:0034654 - The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids. - biological_process - nucleobase, nucleoside, nucleotide and nucleic acid anabolism - nucleobase, nucleoside, nucleotide and nucleic acid biosynthesis - nucleobase, nucleoside, nucleotide and nucleic acid formation - nucleobase, nucleoside, nucleotide and nucleic acid synthesis - - - - - GOC:mah - The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids. - - - - - - - - - - nucleobase-containing compound catabolic process - - - - - - GO:0034655 - The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids. - biological_process - nucleobase, nucleoside, nucleotide and nucleic acid breakdown - nucleobase, nucleoside, nucleotide and nucleic acid catabolic process - nucleobase, nucleoside, nucleotide and nucleic acid catabolism - nucleobase, nucleoside, nucleotide and nucleic acid degradation - - - - - - - GOC:dph - GOC:tb - nucleobase, nucleoside, nucleotide and nucleic acid catabolic process - - - - - GOC:mah - The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids. - - - - - - - - - - protein localization to microtubule - - 2010-03-11T11:00:56Z - A process in which a protein is transported to, or maintained at, a microtubule. - GO:0035372 - biological_process - protein localisation to microtubule - rfoulger - - - - GOC:mah - protein localisation to microtubule - - - - - A process in which a protein is transported to, or maintained at, a microtubule. - GOC:bf - GOC:lb - - - - - - - - - - intracellular signal transduction - - - - - - - - - - - - - - - - - - - 2010-05-14T01:14:37Z - GO:0007242 - GO:0007243 - GO:0023013 - GO:0023034 - GO:0035556 - Reactome:REACT_100795 - Reactome:REACT_102462 - Reactome:REACT_104200 - Reactome:REACT_108216 - Reactome:REACT_1525 - Reactome:REACT_80030 - Reactome:REACT_83068 - Reactome:REACT_83869 - Reactome:REACT_87453 - Reactome:REACT_89085 - Reactome:REACT_89983 - Reactome:REACT_90740 - Reactome:REACT_99938 - The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. - biological_process - intracellular protein kinase cascade - intracellular signal transduction pathway - intracellular signaling cascade - intracellular signaling chain - intracellular signaling pathway - protein kinase cascade - rfoulger - signal transduction via intracellular signaling cascade - signal transmission via intracellular cascade - - - - PKA-mediated phosphorylation of key metabolic factors, Danio rerio - Reactome:REACT_89983 - - - - - PKA-mediated phosphorylation of key metabolic factors, Dictyostelium discoideum - Reactome:REACT_108216 - - - - - PKA-mediated phosphorylation of key metabolic factors, Taeniopygia guttata - Reactome:REACT_104200 - - - - - PKA-mediated phosphorylation of key metabolic factors, Bos taurus - Reactome:REACT_87453 - - - - - ISBN:3527303782 - intracellular signaling chain - - - - - PKA-mediated phosphorylation of key metabolic factors, Homo sapiens - Reactome:REACT_1525 - - - - - PKA-mediated phosphorylation of key metabolic factors, Canis familiaris - Reactome:REACT_102462 - - - - - PKA-mediated phosphorylation of key metabolic factors, Gallus gallus - Reactome:REACT_83068 - - - - - PKA-mediated phosphorylation of key metabolic factors, Saccharomyces cerevisiae - Reactome:REACT_100795 - - - - - GOC:signaling - protein kinase cascade - - - - - GOC:bf - GOC:jl - GOC:signaling - ISBN:3527303782 - The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. - - - - - PKA-mediated phosphorylation of key metabolic factors, Sus scrofa - Reactome:REACT_80030 - - - - - PKA-mediated phosphorylation of key metabolic factors, Schizosaccharomyces pombe - Reactome:REACT_90740 - - - - - GOC:signaling - intracellular signaling cascade - - - - - PKA-mediated phosphorylation of key metabolic factors, Xenopus tropicalis - Reactome:REACT_83869 - - - - - PKA-mediated phosphorylation of key metabolic factors, Rattus norvegicus - Reactome:REACT_89085 - - - - - PKA-mediated phosphorylation of key metabolic factors, Mus musculus - Reactome:REACT_99938 - - - - - GOC:signaling - intracellular protein kinase cascade - - - - - - - - - - site of double-strand break - - 2011-05-17T03:04:42Z - A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. - DNA damage foci - DNA damage focus - GO:0035861 - IRIF - cellular_component - ionizing radiation-induced foci - rfoulger - site of DSB - - - - DNA damage focus - GOC:mah - PMID:20096808 - PMID:21035408 - - - - - PMID:20096808 - PMID:21035408 - ionizing radiation-induced foci - - - - - PMID:21035408 - site of DSB - - - - - DNA damage foci - GOC:vw - - - - - IRIF - PMID:20096808 - PMID:21035408 - - - - - A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. - GOC:bf - GOC:mah - GOC:vw - PMID:20096808 - PMID:21035408 - - - - - - - - - - somatodendritic compartment - - 2014-07-24T10:06:19Z - GO:0036477 - The region of a neuron that includes the cell body (cell soma) and the dendrite, but excludes the axon. - cellular_component - rebeccafoulger - - - - GOC:PARL - GOC:pad - The region of a neuron that includes the cell body (cell soma) and the dendrite, but excludes the axon. - - - - - - - - - - growth - - - GO:0040007 - GO:0048590 - See also the biological process term 'cell growth ; GO:0016049'. - The increase in size or mass of an entire organism, a part of an organism or a cell. - biological_process - growth pattern - non-developmental growth - - - - - - - - - GOC:bf - GOC:ma - The increase in size or mass of an entire organism, a part of an organism or a cell. - - - - - GOC:mah - non-developmental growth - - - - - - - - - - locomotion - - - GO:0040011 - Self-propelled movement of a cell or organism from one location to another. - biological_process - - - - - - - - GOC:dgh - Self-propelled movement of a cell or organism from one location to another. - - - - - - - - - - response to chemical - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus. - GO:0042221 - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - biological_process - response to chemical stimulus - response to chemical substance - - - - - - - - - GOC:dos - response to chemical stimulus - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus. - GOC:jl - - - - - - - - - - regulation of protein import into nucleus - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus. - GO:0042306 - biological_process - regulation of protein import into cell nucleus - regulation of protein transport from cytoplasm to nucleus - regulation of protein-nucleus import - - - - Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus. - GOC:jl - - - - - - - - - - positive regulation of protein import into nucleus - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus. - GO:0042307 - activation of protein import into nucleus - biological_process - positive regulation of protein import into cell nucleus - positive regulation of protein transport from cytoplasm to nucleus - positive regulation of protein-nucleus import - stimulation of protein import into nucleus - up regulation of protein import into nucleus - up-regulation of protein import into nucleus - upregulation of protein import into nucleus - - - - Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus. - GOC:jl - - - - - - - - - - negative regulation of protein import into nucleus - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus. - GO:0042308 - biological_process - down regulation of protein import into nucleus - down-regulation of protein import into nucleus - downregulation of protein import into nucleus - inhibition of protein import into nucleus - negative regulation of protein import into cell nucleus - negative regulation of protein transport from cytoplasm to nucleus - negative regulation of protein-nucleus import - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus. - GOC:jl - - - - - - - - - - regulation of NF-kappaB import into nucleus - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane. - GO:0042345 - biological_process - regulation of NF-kappaB import into cell nucleus - regulation of NF-kappaB transport from cytoplasm to nucleus - regulation of NF-kappaB-nucleus import - - - - Any process that modulates the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane. - GOC:jl - ISBN:0198506732 - - - - - - - - - - positive regulation of NF-kappaB import into nucleus - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane. - GO:0042346 - activation of NF-kappaB import into nucleus - biological_process - positive regulation of NF-kappaB import into cell nucleus - positive regulation of NF-kappaB transport from cytoplasm to nucleus - positive regulation of NF-kappaB-nucleus import - stimulation of NF-kappaB import into nucleus - up regulation of NF-kappaB import into nucleus - up-regulation of NF-kappaB import into nucleus - upregulation of NF-kappaB import into nucleus - - - - Any process that activates or increases the frequency, rate or extent of transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane. - GOC:jl - ISBN:0198506732 - - - - - - - - - - negative regulation of NF-kappaB import into nucleus - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane. - GO:0042347 - biological_process - down regulation of NF-kappaB import into nucleus - down-regulation of NF-kappaB import into nucleus - downregulation of NF-kappaB import into nucleus - inhibition of NF-kappaB import into nucleus - negative regulation of NF-kappaB import into cell nucleus - negative regulation of NF-kappaB transport from cytoplasm to nucleus - negative regulation of NF-kappaB-nucleus import - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane. - GOC:jl - ISBN:0198506732 - - - - - - - - - - NF-kappaB import into nucleus - - - - - - - - - - GO:0042348 - NF-KB import into nucleus - NF-kappaB import into cell nucleus - NF-kappaB protein-nucleus import - NF-kappaB transport from cytoplasm to nucleus - NF-kappaB-nucleus import - The directed movement of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane. - biological_process - - - - GOC:jl - ISBN:0198506732 - The directed movement of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane. - - - - - GOC:bf - NF-KB import into nucleus - - - - - - - - - - paraspeckles - - Discrete subnuclear bodies in the interchromatin nucleoplasmic space, often located adjacent to nuclear specks. 10-20 paraspeckles are typically found in human cell nuclei. - GO:0042382 - Wikipedia:Paraspeckle - cellular_component - - - - Discrete subnuclear bodies in the interchromatin nucleoplasmic space, often located adjacent to nuclear specks. 10-20 paraspeckles are typically found in human cell nuclei. - GOC:jl - PMID:11790299 - - - - - - - - - - actomyosin - - - - - - - - Any complex of actin, myosin, and accessory proteins. - GO:0042641 - actomyosin complex - actomyosin structure - cellular_component - - - - Any complex of actin, myosin, and accessory proteins. - GOC:go_curators - - - - - - - - - - monopolar cell growth - - GO:0042814 - Polarized growth from one end of a cell. - biological_process - monopolar cell elongation - monopolar growth - polar cell elongation - - - - GOC:vw - Polarized growth from one end of a cell. - - - - - - - - - - amide transport - - - GO:0042886 - The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - biological_process - - - - - - GOC:jl - ISBN:0198506732 - The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - - - - - - - - - - regulation of transcription factor import into nucleus - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus. - GO:0042990 - biological_process - regulation of transcription factor import into cell nucleus - regulation of transcription factor transport from cytoplasm to nucleus - regulation of transcription factor-nucleus import - - - - Any process that modulates the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus. - GOC:jl - - - - - - - - - - transcription factor import into nucleus - - GO:0042991 - The directed movement of a transcription factor from the cytoplasm to the nucleus. - biological_process - transcription factor import into cell nucleus - transcription factor transport from cytoplasm to nucleus - transcription factor-nucleus import - - - - GOC:jl - The directed movement of a transcription factor from the cytoplasm to the nucleus. - - - - - - - - - - negative regulation of transcription factor import into nucleus - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus. - GO:0042992 - biological_process - down regulation of transcription factor import into nucleus - down-regulation of transcription factor import into nucleus - downregulation of transcription factor import into nucleus - inhibition of transcription factor import into nucleus - negative regulation of transcription factor import into cell nucleus - negative regulation of transcription factor transport from cytoplasm to nucleus - negative regulation of transcription factor-nucleus import - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus. - GOC:jl - - - - - - - - - - positive regulation of transcription factor import into nucleus - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus. - GO:0042993 - activation of transcription factor import into nucleus - biological_process - positive regulation of transcription factor import into cell nucleus - positive regulation of transcription factor transport from cytoplasm to nucleus - positive regulation of transcription factor-nucleus import - stimulation of transcription factor import into nucleus - up regulation of transcription factor import into nucleus - up-regulation of transcription factor import into nucleus - upregulation of transcription factor import into nucleus - - - - Any process that activates or increases the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus. - GOC:jl - - - - - - - - - - cytoplasmic sequestering of transcription factor - - - GO:0042994 - The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus. - biological_process - cytoplasmic retention of transcription factor - cytoplasmic sequestration of transcription factor - cytoplasmic storage of transcription factor - maintenance of transcription factor protein location in cytoplasm - retention of transcription factor in cytoplasm - sequestering of transcription factor in cytoplasm - sequestration of transcription factor in cytoplasm - storage of transcription factor in cytoplasm - transcription factor binding, cytoplasmic sequestering - - - - GOC:dph - GOC:tb - maintenance of transcription factor protein location in cytoplasm - - - - - GOC:jl - The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus. - - - - - - - - - - cell projection - - A prolongation or process extending from a cell, e.g. a flagellum or axon. - GO:0042995 - cell process - cellular process - cellular projection - cellular_component - - - - - - A prolongation or process extending from a cell, e.g. a flagellum or axon. - GOC:jl - http://www.cogsci.princeton.edu/~wn/ - - - - - - - - - - neuron projection - - - A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. - GO:0043005 - NIF_Subcellular:sao-867568886 - cellular_component - neurite - neuron process - neuron protrusion - neuronal cell projection - - - - - NIF_Subcellular:sao-250931889 - neuron protrusion - - - - - A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. - GOC:jl - http://www.cogsci.princeton.edu/~wn/ - - - - - - - - - - regulation of I-kappaB kinase/NF-kappaB signaling - - - - - - - - - - - - - - - - - - - Any process that modulates I-kappaB kinase/NF-kappaB signaling. - GO:0043122 - biological_process - regulation of I-kappaB kinase/NF-kappaB cascade - - - - GOC:signaling - regulation of I-kappaB kinase/NF-kappaB cascade - - - - - Any process that modulates I-kappaB kinase/NF-kappaB signaling. - GOC:jl - PMID:12773372 - - - - - - - - - - positive regulation of I-kappaB kinase/NF-kappaB signaling - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling. - GO:0043123 - Reactome:REACT_24918 - activation of I-kappaB kinase/NF-kappaB cascade - biological_process - positive regulation of I-kappaB kinase/NF-kappaB cascade - stimulation of I-kappaB kinase/NF-kappaB cascade - up regulation of I-kappaB kinase/NF-kappaB cascade - up-regulation of I-kappaB kinase/NF-kappaB cascade - upregulation of I-kappaB kinase/NF-kappaB cascade - - - - Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling. - GOC:jl - - - - - IRAK1 recruits IKK complex, Homo sapiens - Reactome:REACT_24918 - - - - - GOC:signaling - positive regulation of I-kappaB kinase/NF-kappaB cascade - - - - - - - - - - negative regulation of I-kappaB kinase/NF-kappaB signaling - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling. - GO:0043124 - biological_process - down regulation of I-kappaB kinase/NF-kappaB cascade - down-regulation of I-kappaB kinase/NF-kappaB cascade - downregulation of I-kappaB kinase/NF-kappaB cascade - inhibition of I-kappaB kinase/NF-kappaB cascade - negative regulation of I-kappaB kinase/NF-kappaB cascade - - - - GOC:signaling - negative regulation of I-kappaB kinase/NF-kappaB cascade - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling. - GOC:jl - - - - - - - - - - macromolecule metabolic process - - GO:0043170 - GO:0043283 - The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - biological_process - biopolymer metabolic process - macromolecule metabolism - - - - - - CHEBI:33694 - GOC:mah - The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - - - - - GOC:mtg_chebi_dec09 - biopolymer metabolic process - - - - - - - - - - organelle - - GO:0043226 - NIF_Subcellular:sao1539965131 - Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane. - Wikipedia:Organelle - cellular_component - - - - - - - - GOC:go_curators - Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane. - - - - - - - - - - membrane-bounded organelle - - GO:0043227 - NIF_Subcellular:sao414196390 - Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. - cellular_component - membrane-enclosed organelle - - - - - GOC:go_curators - Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. - - - - - - - - - - non-membrane-bounded organelle - - GO:0043228 - NIF_Subcellular:sao1456184038 - Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes. - cellular_component - non-membrane-enclosed organelle - - - - - GOC:go_curators - Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes. - - - - - - - - - - intracellular organelle - - - GO:0043229 - Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. - cellular_component - - - - - - GOC:go_curators - Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. - - - - - - - - - - intracellular membrane-bounded organelle - - - GO:0043231 - Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. - cellular_component - intracellular membrane-enclosed organelle - - - - - - GOC:go_curators - Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. - - - - - - - - - - intracellular non-membrane-bounded organelle - - - GO:0043232 - Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes. - cellular_component - intracellular non-membrane-enclosed organelle - - - - - - GOC:go_curators - Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes. - - - - - - - - - - organelle lumen - - - GO:0043233 - The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen. - cellular_component - - - - GOC:jl - GOC:mah - The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen. - - - - - - - - - - protein complex - - A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole. - A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical. - GO:0043234 - Wikipedia:Protein_complex - cellular_component - protein-protein complex - - - - - - - - A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical. - GOC:go_curators - http://www.ebi.ac.uk/intact/complex/documentation/ - - - - - - - - - - negative regulation of sequence-specific DNA binding transcription factor activity - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. - GO:0043433 - biological_process - down regulation of transcription factor activity - down-regulation of transcription factor activity - downregulation of transcription factor activity - inhibition of transcription factor activity - negative regulation of transcription factor activity - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. - GOC:jl - - - - - GOC:dph - GOC:tb - negative regulation of transcription factor activity - - - - - - - - - - sequence-specific DNA binding - - GO:0043565 - Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. - molecular_function - sequence specific DNA binding - - - - - GOC:jl - Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. - - - - - - - - - - cellular component biogenesis - - A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component. - GO:0044085 - GO:0071843 - biological_process - cellular component biogenesis at cellular level - - - - - A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component. - GOC:jl - GOC:mah - - - - - - - - - - negative regulation of molecular function - - - - - - - - - - - - - - - - - - - 2009-04-21T04:07:27Z - Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. - GO:0044092 - biological_process - jane - - - - Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. - GO:jl - - - - - - - - - - positive regulation of molecular function - - - - - - - - - - - - - - - - - - - 2009-04-21T04:11:06Z - Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. - GO:0044093 - biological_process - jane - - - - Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. - GO:jl - - - - - - - - - - transcription regulatory region DNA binding - - 2009-11-04T12:58:25Z - GO:0044212 - Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors. - The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding". - jane - molecular_function - - - - GOC:jl - GOC:txnOH - Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors. - SO:0005836 - - - - - - - - - - cellular metabolic process - - - GO:0044237 - The chemical reactions and pathways by which individual cells transform chemical substances. - biological_process - cellular metabolism - intermediary metabolism - - - - - - GOC:go_curators - The chemical reactions and pathways by which individual cells transform chemical substances. - - - - - GOC:mah - intermediary metabolism - - - - - - - - - - primary metabolic process - - GO:0044238 - The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. - biological_process - primary metabolism - - - - - - GOC:go_curators - The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. - http://www.metacyc.org - - - - - - - - - - cellular catabolic process - - - GO:0044248 - The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. - biological_process - cellular breakdown - cellular catabolism - cellular degradation - - - - - GOC:jl - The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. - - - - - - - - - - cellular biosynthetic process - - - GO:0044249 - The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. - biological_process - cellular anabolism - cellular biosynthesis - cellular formation - cellular synthesis - - - - - GOC:jl - The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. - - - - - - - - - - cellular macromolecule metabolic process - - - GO:0034960 - GO:0044260 - The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells. - biological_process - cellular biopolymer metabolic process - cellular macromolecule metabolism - - - - - GOC:mtg_chebi_dec09 - cellular biopolymer metabolic process - - - - - CHEBI:33694 - GOC:mah - The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells. - - - - - - - - - - cellular macromolecule catabolic process - - - - GO:0034962 - GO:0044265 - The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates, as carried out by individual cells. - biological_process - cellular biopolymer catabolic process - cellular macromolecule breakdown - cellular macromolecule catabolism - cellular macromolecule degradation - - - - - GOC:mtg_chebi_dec09 - cellular biopolymer catabolic process - - - - - CHEBI:33694 - GOC:jl - The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates, as carried out by individual cells. - - - - - - - - - - cellular nitrogen compound catabolic process - - - GO:0044270 - The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds. - biological_process - nitrogen compound breakdown - nitrogen compound catabolism - nitrogen compound degradation - - - - - GOC:jl - ISBN:0198506732 - The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds. - - - - - - - - - - cellular nitrogen compound biosynthetic process - - - GO:0044271 - The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds. - biological_process - nitrogen compound anabolism - nitrogen compound biosynthesis - nitrogen compound formation - nitrogen compound synthesis - - - - - GOC:jl - ISBN:0198506732 - The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds. - - - - - - - - - - dendritic branch - - - - - - - - - 2010-02-05T04:18:53Z - A dendrite arising from another dendrite. - GO:0044307 - NIF_Subcellular:sao884265541 - cellular_component - dendrite branch - jane - - - - A dendrite arising from another dendrite. - NIF_Subcellular:sao884265541 - - - - - - - - - - protein localization to cytoskeleton - - 2011-12-13T11:43:24Z - A process in which a protein is transported to, or maintained in, a location within the cytoskeleton. - GO:0044380 - biological_process - janelomax - protein localisation to cytoskeleton - - - - A process in which a protein is transported to, or maintained in, a location within the cytoskeleton. - GOC:jl - - - - - GOC:mah - protein localisation to cytoskeleton - - - - - - - - - - organelle part - - - - - - - - - - - - - - - - - - - Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane. - GO:0044422 - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - cellular_component - - - - - - - Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane. - GOC:jl - - - - - - - - - - intracellular part - - - - - - - - - - - - - - - - - - - Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. - GO:0044424 - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - cellular_component - - - - - - - Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. - GOC:jl - - - - - - - - - - chromosomal part - - - - - - - - - - - - - - - - - - - Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. - GO:0044427 - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - cellular_component - chromosomal component - chromosome component - chromosome part - - - - - - - Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. - GOC:jl - - - - - - - - - - nuclear part - - - - - - - - - - - - - - - - - - - Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. - GO:0044428 - NIF_Subcellular:sao1499850686 - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - cellular_component - nuclear subcomponent - nucleus component - - - - - - Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. - GOC:jl - - - - - NIF_Subcellular:sao1499850686 - nuclear subcomponent - - - - - - - - - - mitochondrial part - - - - - - - - - - - - - - - - - - - - Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. - GO:0044429 - NIF_Subcellular:sao666410040 - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - cellular_component - mitochondrial subcomponent - mitochondrion component - - - - - - NIF_Subcellular:sao666410040 - mitochondrial subcomponent - - - - - Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. - GOC:jl - - - - - - - - - - cytoskeletal part - - - - - - - - - - - - - - - - - - - Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice. - GO:0044430 - NIF_Subcellular:sao1635329413 - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - cellular_component - cytoskeletal element - cytoskeleton component - - - - - - Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice. - GOC:jl - - - - - NIF_Subcellular:sao1635329413 - cytoskeletal element - - - - - - - - - - Golgi apparatus part - - - - - - - - - - - - - - - - - - - - Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. - GO:0044431 - Golgi component - Golgi subcomponent - NIF_Subcellular:sao624292949 - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - cellular_component - - - - - - Golgi subcomponent - NIF_Subcellular:sao624292949 - - - - - Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. - GOC:jl - - - - - - - - - - endoplasmic reticulum part - - - - - - - - - - - - - - - - - - - - Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. - ER component - GO:0044432 - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - cellular_component - - - - - - Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. - GOC:jl - - - - - - - - - - cytoplasmic part - - - - - - - - - - - - - - - - - - - Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. - GO:0044444 - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - cellular_component - cytoplasm component - - - - - - - Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. - GOC:jl - - - - - - - - - - intracellular organelle part - - - - - - - - - A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane. - GO:0044446 - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - cellular_component - - - - - - A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane. - GOC:jl - - - - - - - - - - cell cortex part - - - - - - - - - - - - - - - - - - - Any constituent part of the cell cortex, the region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. - GO:0044448 - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - cellular_component - - - - - - Any constituent part of the cell cortex, the region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. - GOC:jl - - - - - - - - - - nucleoplasm part - - - - - - - - - - - - - - - - - - - Any constituent part of the nucleoplasm, that part of the nuclear content other than the chromosomes or the nucleolus. - GO:0044451 - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - cellular_component - - - - - - Any constituent part of the nucleoplasm, that part of the nuclear content other than the chromosomes or the nucleolus. - GOC:jl - - - - - - - - - - cell projection part - - - - - - - - - - - - - - - - - - - Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon. - GO:0044463 - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - cellular_component - - - - - - - Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon. - GOC:jl - - - - - - - - - - cell part - - - - - - - - - - - - - - - - - - - Any constituent part of a cell, the basic structural and functional unit of all organisms. - GO:0044464 - NIF_Subcellular:sao628508602 - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - cellular subcomponent - cellular_component - protoplast - - - - - - - - NIF_Subcellular:sao628508602 - cellular subcomponent - - - - - GOC:mah - protoplast - - - - - Any constituent part of a cell, the basic structural and functional unit of all organisms. - GOC:jl - - - - - - - - - - single-organism process - - - 2012-09-19T15:05:24Z - A biological process that involves only one organism. - GO:0044699 - biological_process - janelomax - single organism process - - - - A biological process that involves only one organism. - GOC:jl - - - - - - - - - - single organism signaling - - - 2012-09-19T15:12:49Z - A signaling process occurring within a single organism. - GO:0044700 - biological_process - janelomax - - - - A signaling process occurring within a single organism. - GOC:jl - - - - - - - - - - protein targeting to nucleus - - - - - - 2012-11-07T15:45:54Z - GO:0044744 - The process of directing proteins towards the nucleus, usually using signals contained within the protein. - biological_process - janelomax - - - - GOC:jl - The process of directing proteins towards the nucleus, usually using signals contained within the protein. - - - - - - - - - - single-organism cellular process - - - 2012-12-11T16:56:55Z - Any process that is carried out at the cellular level, occurring within a single organism. - GO:0044763 - biological_process - janelomax - - - - Any process that is carried out at the cellular level, occurring within a single organism. - GOC:jl - - - - - - - - - - single-organism transport - - - 2012-12-13T16:25:32Z - GO:0044765 - The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore, involving a single organism. - biological_process - janelomax - - - - GOC:jl - The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore, involving a single organism. - - - - - - - - - - single-organism developmental process - - - 2012-12-19T12:21:31Z - A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition, involving only one organism. - GO:0044767 - biological_process - janelomax - - - - A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition, involving only one organism. - GOC:jl - - - - - - - - - - cell cycle phase transition - - 2013-02-28T12:54:59Z - GO:0044770 - The cell cycle process by which a cell commits to entering the next cell cycle phase. - biological_process - cell cycle transition - janelomax - - - - GOC:mtg_cell_cycle - The cell cycle process by which a cell commits to entering the next cell cycle phase. - - - - - - - - - - mitotic cell cycle phase transition - - - - - - - - - - - - - - - - - - - - 2013-02-28T13:09:33Z - GO:0044772 - The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase. - biological_process - janelomax - - - - GOC:mtg_cell_cycle - The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase. - - - - - - - - - - single-organism membrane fusion - - - 2013-09-10T15:08:20Z - GO:0044801 - The membrane organization process that joins two lipid bilayers to form a single membrane, involving only one organism. - biological_process - janelomax - - - - GOC:jl - The membrane organization process that joins two lipid bilayers to form a single membrane, involving only one organism. - - - - - - - - - - single-organism membrane organization - - - 2013-09-10T15:11:17Z - A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane, involving only one organism. - GO:0044802 - biological_process - janelomax - - - - A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane, involving only one organism. - GOC:jl - - - - - - - - - - cell cycle G2/M phase transition - - 2014-03-05T14:56:45Z - GO:0044839 - The cell cycle process by which a cell in G2 phase commits to M phase. - biological_process - janelomax - - - - GOC:jl - GOC:mtg_cell_cycle - The cell cycle process by which a cell in G2 phase commits to M phase. - - - - - - - - - - biological phase - - - - - 2014-07-16T13:12:40Z - A distinct period or stage in a biological process or cycle. - GO:0044848 - Note that phases are is_a disjoint from other biological processes. happens_during relationships can operate between phases and other biological processes e.g. DNA replication happens_during S phase. - biological_process - janelomax - - - - - A distinct period or stage in a biological process or cycle. - GOC:jl - - - - - - - - - - G0 to G1 transition - - GO:0045023 - The mitotic cell cycle phase transition whose occurrence commits the cell from the G0 quiescent state to the G1 phase. Under certain conditions, cells exit the cell cycle during G1 and remain in the G0 state as nongrowing, non-dividing (quiescent) cells. Appropriate stimulation of such cells induces them to return to G1 and resume growth and division. The G0 to G1 transition is accompanied by many changes in the program of gene expression. - biological_process - - - - GOC:mtg_cell_cycle - ISBN:0716731363 - The mitotic cell cycle phase transition whose occurrence commits the cell from the G0 quiescent state to the G1 phase. Under certain conditions, cells exit the cell cycle during G1 and remain in the G0 state as nongrowing, non-dividing (quiescent) cells. Appropriate stimulation of such cells induces them to return to G1 and resume growth and division. The G0 to G1 transition is accompanied by many changes in the program of gene expression. - - - - - - - - - - plasma membrane fusion - - GO:0006947 - GO:0045026 - The joining of two or more lipid bilayer membranes that surround a cell. - biological_process - cell fusion - cell-cell fusion - - - - GOC:elh - GOC:mtg_muscle - The joining of two or more lipid bilayer membranes that surround a cell. - - - - - - - - - - establishment of protein localization - - - - - - - - GO:0045184 - The directed movement of a protein to a specific location. - biological_process - establishment of protein localisation - protein positioning - protein recruitment - - - - - GOC:bf - The directed movement of a protein to a specific location. - - - - - GOC:mah - establishment of protein localisation - - - - - - - - - - maintenance of protein location - - - - - - - - Any process in which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away. - GO:0045185 - active protein retrieval - biological_process - maintenance of protein localization - protein retention - protein sequestering - - - - - GOC:dph - GOC:tb - maintenance of protein localization - - - - - Any process in which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away. - GOC:bf - - - - - - - - - - phagocytic vesicle - - A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis. - GO:0045335 - Wikipedia:Phagosome - cellular_component - phagosome - - - - A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis. - GOC:go_curators - ISBN:0198506732 - - - - - - - - - - negative regulation of transcription, DNA-templated - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. - GO:0016481 - GO:0032582 - GO:0045892 - GO:0061021 - biological_process - down regulation of gene-specific transcription - down regulation of transcription, DNA-dependent - down-regulation of gene-specific transcription - down-regulation of transcription, DNA-dependent - downregulation of gene-specific transcription - downregulation of transcription, DNA-dependent - inhibition of gene-specific transcription - inhibition of transcription, DNA-dependent - negative regulation of cellular transcription, DNA-dependent - negative regulation of gene-specific transcription - negative regulation of transcription, DNA-dependent - transcription repressor activity - - - - - GOC:txnOH - negative regulation of transcription, DNA-dependent - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. - GOC:go_curators - GOC:txnOH - - - - - - - - - - positive regulation of transcription, DNA-templated - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. - GO:0043193 - GO:0045893 - GO:0045941 - GO:0061020 - activation of gene-specific transcription - activation of transcription, DNA-dependent - biological_process - positive regulation of cellular transcription, DNA-dependent - positive regulation of gene-specific transcription - positive regulation of transcription, DNA-dependent - stimulation of gene-specific transcription - stimulation of transcription, DNA-dependent - transcription activator activity - up regulation of gene-specific transcription - up regulation of transcription, DNA-dependent - up-regulation of gene-specific transcription - up-regulation of transcription, DNA-dependent - upregulation of gene-specific transcription - upregulation of transcription, DNA-dependent - - - - - Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. - GOC:go_curators - GOC:txnOH - - - - - GOC:txnOH - positive regulation of transcription, DNA-dependent - - - - - - - - - - negative regulation of nucleobase-containing compound metabolic process - - - - - - - - - - - - - - - - - - - - - Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. - GO:0045934 - biological_process - down regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process - down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process - downregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process - inhibition of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process - negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process - negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism - - - - - Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. - GOC:go_curators - - - - - GOC:dph - GOC:tb - negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process - - - - - - - - - - positive regulation of nucleobase-containing compound metabolic process - - - - - - - - - - - - - - - - - - - - - Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. - GO:0045935 - activation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process - biological_process - positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process - positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism - stimulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process - up regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process - up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process - upregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process - - - - - GOC:dph - GOC:tb - positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process - - - - - Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. - GOC:go_curators - - - - - - - - - - heterocycle metabolic process - - GO:0046483 - The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). - biological_process - heterocycle metabolism - - - - - - CHEBI:5686 - ISBN:0198506732 - The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). - - - - - - - - - - heterocycle catabolic process - - - GO:0046700 - The chemical reactions and pathways resulting in the breakdown of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). - biological_process - heterocycle breakdown - heterocycle catabolism - heterocycle degradation - - - - - GOC:ai - The chemical reactions and pathways resulting in the breakdown of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). - - - - - - - - - - regulation of nucleocytoplasmic transport - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm. - GO:0046822 - biological_process - - - - Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm. - GOC:bf - - - - - - - - - - negative regulation of nucleocytoplasmic transport - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances between the cytoplasm and the nucleus. - GO:0046823 - biological_process - down regulation of nucleocytoplasmic transport - down-regulation of nucleocytoplasmic transport - downregulation of nucleocytoplasmic transport - inhibition of nucleocytoplasmic transport - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances between the cytoplasm and the nucleus. - GOC:bf - - - - - - - - - - positive regulation of nucleocytoplasmic transport - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm. - GO:0046824 - activation of nucleocytoplasmic transport - biological_process - stimulation of nucleocytoplasmic transport - up regulation of nucleocytoplasmic transport - up-regulation of nucleocytoplasmic transport - upregulation of nucleocytoplasmic transport - - - - Any process that activates or increases the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm. - GOC:bf - - - - - - - - - - secretion - - GO:0046903 - The controlled release of a substance by a cell or a tissue. - biological_process - - - - - - GOC:ai - The controlled release of a substance by a cell or a tissue. - - - - - - - - - - intracellular transport - - - - - - - - - GO:0046907 - The directed movement of substances within a cell. - biological_process - - - - - GOC:ai - The directed movement of substances within a cell. - - - - - - - - - - organelle fission - - GO:0048285 - The creation of two or more organelles by division of one organelle. - biological_process - - - - - - GOC:jid - The creation of two or more organelles by division of one organelle. - - - - - - - - - - cell development - - - - - - - - - GO:0048468 - The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. - biological_process - terminal differentiation - - - - - - GOC:go_curators - The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. - - - - - GOC:dph - GOC:tb - terminal differentiation - - - - - - - - - - positive regulation of biological process - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. - GO:0043119 - GO:0048518 - activation of biological process - biological_process - positive regulation of physiological process - stimulation of biological process - up regulation of biological process - up-regulation of biological process - upregulation of biological process - - - - - Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. - GOC:jid - - - - - - - - - - negative regulation of biological process - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. - GO:0043118 - GO:0048519 - biological_process - down regulation of biological process - down-regulation of biological process - downregulation of biological process - inhibition of biological process - negative regulation of physiological process - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. - GOC:jid - - - - - - - - - - positive regulation of cellular process - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. - GO:0048522 - GO:0051242 - activation of cellular process - biological_process - positive regulation of cellular physiological process - stimulation of cellular process - up regulation of cellular process - up-regulation of cellular process - upregulation of cellular process - - - - - Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. - GOC:jid - - - - - - - - - - negative regulation of cellular process - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. - GO:0048523 - GO:0051243 - biological_process - down regulation of cellular process - down-regulation of cellular process - downregulation of cellular process - inhibition of cellular process - negative regulation of cellular physiological process - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. - GOC:jid - - - - - - - - - - regulation of response to stimulus - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. - GO:0048583 - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - biological_process - - - - - - Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. - GOC:jid - - - - - - - - - - positive regulation of response to stimulus - - - - - - - - - - - - - - - - - - - - Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. - GO:0048584 - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - activation of response to stimulus - biological_process - stimulation of response to stimulus - up regulation of response to stimulus - up-regulation of response to stimulus - upregulation of response to stimulus - - - - - Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. - GOC:jid - - - - - - - - - - negative regulation of response to stimulus - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. - GO:0048585 - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - biological_process - down regulation of response to stimulus - down-regulation of response to stimulus - downregulation of response to stimulus - inhibition of response to stimulus - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. - GOC:jid - - - - - - - - - - developmental growth - - - GO:0048589 - The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. - biological_process - - - - GOC:go_curators - The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. - - - - - - - - - - anatomical structure development - - GO:0048856 - The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. - This term was added by GO_REF:0000021. - biological_process - development of an anatomical structure - - - - - - GOC:mtg_15jun06 - GO_REF:0000021 - The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. - - - - - - - - - - cellular developmental process - - - A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition. - GO:0048869 - biological_process - - - - - A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition. - GOC:isa_complete - - - - - - - - - - cell motility - - - - - - - - - Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another. - GO:0048870 - biological_process - cell locomotion - cell movement - movement of a cell - - - - - - - - Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another. - GOC:dgh - GOC:dph - GOC:isa_complete - GOC:mlg - - - - - - - - - - chromosome localization - - Any process in which a chromosome is transported to, or maintained in, a specific location. - GO:0050000 - biological_process - chromosome localisation - establishment and maintenance of chromosome localization - establishment and maintenance of chromosome position - - - - GOC:mah - chromosome localisation - - - - - Any process in which a chromosome is transported to, or maintained in, a specific location. - GOC:ai - - - - - - - - - - regulation of biological process - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. - GO:0050789 - GO:0050791 - biological_process - regulation of physiological process - - - - - - - Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. - GOC:ai - GOC:go_curators - - - - - - - - - - regulation of cellular process - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. - GO:0050794 - GO:0051244 - biological_process - regulation of cellular physiological process - - - - - Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. - GOC:go_curators - - - - - - - - - - response to stimulus - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. - GO:0050896 - GO:0051869 - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - biological_process - physiological response to stimulus - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. - GOC:ai - GOC:bf - - - - - - - - - - regulation of transport - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GO:0051049 - biological_process - - - - - - Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:ai - - - - - - - - - - positive regulation of transport - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GO:0051050 - activation of transport - biological_process - stimulation of transport - up regulation of transport - up-regulation of transport - upregulation of transport - - - - - Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:ai - - - - - - - - - - negative regulation of transport - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GO:0051051 - biological_process - down regulation of transport - down-regulation of transport - downregulation of transport - inhibition of transport - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:ai - - - - - - - - - - regulation of sequence-specific DNA binding transcription factor activity - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. - GO:0051090 - Reactome:REACT_104536 - Reactome:REACT_107559 - Reactome:REACT_109535 - Reactome:REACT_110257 - Reactome:REACT_110693 - Reactome:REACT_21326 - Reactome:REACT_82719 - Reactome:REACT_83365 - Reactome:REACT_90659 - Reactome:REACT_92725 - Reactome:REACT_96476 - Reactome:REACT_99415 - biological_process - regulation of transcription factor activity - - - - - Activation of the AP-1 family of transcription factors, Bos taurus - Reactome:REACT_104536 - - - - - Activation of the AP-1 family of transcription factors, Taeniopygia guttata - Reactome:REACT_90659 - - - - - GOC:dph - GOC:tb - regulation of transcription factor activity - - - - - Activation of the AP-1 family of transcription factors, Gallus gallus - Reactome:REACT_110693 - - - - - Activation of the AP-1 family of transcription factors, Canis familiaris - Reactome:REACT_92725 - - - - - Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. - GOC:ai - - - - - Activation of the AP-1 family of transcription factors, Sus scrofa - Reactome:REACT_83365 - - - - - Activation of the AP-1 family of transcription factors, Homo sapiens - Reactome:REACT_21326 - - - - - Activation of the AP-1 family of transcription factors, Mus musculus - Reactome:REACT_99415 - - - - - Activation of the AP-1 family of transcription factors, Drosophila melanogaster - Reactome:REACT_110257 - - - - - Activation of the AP-1 family of transcription factors, Xenopus tropicalis - Reactome:REACT_82719 - - - - - Activation of the AP-1 family of transcription factors, Schizosaccharomyces pombe - Reactome:REACT_109535 - - - - - Activation of the AP-1 family of transcription factors, Rattus norvegicus - Reactome:REACT_96476 - - - - - Activation of the AP-1 family of transcription factors, Danio rerio - Reactome:REACT_107559 - - - - - - - - - - positive regulation of sequence-specific DNA binding transcription factor activity - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription. - GO:0051091 - activation of transcription factor activity - biological_process - positive regulation of transcription factor activity - stimulation of transcription factor activity - up regulation of transcription factor activity - up-regulation of transcription factor activity - upregulation of transcription factor activity - - - - - GOC:dph - GOC:tb - positive regulation of transcription factor activity - - - - - Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription. - GOC:ai - - - - - - - - - - positive regulation of NF-kappaB transcription factor activity - - Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB. - GO:0051092 - NF-kappaB activation - Reactome:REACT_107873 - Reactome:REACT_113398 - Reactome:REACT_113766 - Reactome:REACT_21281 - Reactome:REACT_31084 - Reactome:REACT_33907 - Reactome:REACT_34168 - Reactome:REACT_34256 - Reactome:REACT_87914 - Reactome:REACT_95400 - activation of NF-kappaB - activation of NF-kappaB transcription factor - biological_process - - - - TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Mus musculus - Reactome:REACT_95400 - - - - - TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Canis familiaris - Reactome:REACT_31084 - - - - - TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Drosophila melanogaster - Reactome:REACT_113766 - - - - - GOC:dph - GOC:tb - activation of NF-kappaB transcription factor - - - - - TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Taeniopygia guttata - Reactome:REACT_113398 - - - - - TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Rattus norvegicus - Reactome:REACT_107873 - - - - - TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Bos taurus - Reactome:REACT_34256 - - - - - TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Xenopus tropicalis - Reactome:REACT_87914 - - - - - TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Sus scrofa - Reactome:REACT_34168 - - - - - Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB. - GOC:dph - GOC:tb - PMID:15087454 - PMID:15170030 - - - - - TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Danio rerio - Reactome:REACT_33907 - - - - - TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Homo sapiens - Reactome:REACT_21281 - - - - - - - - - - nuclear transport - - GO:0051169 - Reactome:REACT_9004 - The directed movement of substances into, out of, or within the nucleus. - Wikipedia:Nuclear_transport - biological_process - nucleus transport - - - - - Import of PIC to the Host Nucleus, Homo sapiens - Reactome:REACT_9004 - - - - - GOC:ai - The directed movement of substances into, out of, or within the nucleus. - - - - - - - - - - nuclear import - - GO:0051170 - Reactome:REACT_10010 - Reactome:REACT_32050 - Reactome:REACT_91459 - Reactome:REACT_97007 - The directed movement of substances into the nucleus. - biological_process - import into nucleus - nucleus import - substance nuclear import - - - - snRNP nuclear import and release, Xenopus tropicalis - Reactome:REACT_32050 - - - - - GOC:ai - The directed movement of substances into the nucleus. - - - - - snRNP nuclear import and release, Homo sapiens - Reactome:REACT_10010 - - - - - snRNP nuclear import and release, Danio rerio - Reactome:REACT_97007 - - - - - snRNP nuclear import and release, Mus musculus - Reactome:REACT_91459 - - - - - - - - - - regulation of nitrogen compound metabolic process - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. - GO:0051171 - biological_process - regulation of nitrogen metabolic process - regulation of nitrogen metabolism - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. - GOC:ai - GOC:tb - - - - - GOC:tb - regulation of nitrogen metabolic process - - - - - - - - - - negative regulation of nitrogen compound metabolic process - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. - GO:0051172 - biological_process - down regulation of nitrogen metabolic process - down-regulation of nitrogen metabolic process - downregulation of nitrogen metabolic process - inhibition of nitrogen metabolic process - negative regulation of nitrogen metabolic process - negative regulation of nitrogen metabolism - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. - GOC:ai - GOC:tb - - - - - GOC:tb - negative regulation of nitrogen metabolic process - - - - - - - - - - positive regulation of nitrogen compound metabolic process - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. - GO:0051173 - activation of nitrogen metabolic process - biological_process - positive regulation of nitrogen metabolic process - positive regulation of nitrogen metabolism - stimulation of nitrogen metabolic process - up regulation of nitrogen metabolic process - up-regulation of nitrogen metabolic process - upregulation of nitrogen metabolic process - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. - GOC:ai - GOC:tb - - - - - GOC:tb - positive regulation of nitrogen metabolic process - - - - - - - - - - localization - - Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to or maintained in a specific location. - GO:0051179 - biological_process - establishment and maintenance of cellular component location - establishment and maintenance of localization - establishment and maintenance of position - establishment and maintenance of substance location - establishment and maintenance of substrate location - localisation - - - - - - Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to or maintained in a specific location. - GOC:ai - - - - - GOC:mah - localisation - - - - - - - - - - cytoplasmic sequestering of protein - - - - - - - - - - - - - - - - - - - - GO:0051220 - The selective interaction of a protein with specific molecules in the cytoplasm, thereby inhibiting its transport into other areas of the cell. - biological_process - cytoplasmic retention of protein - cytoplasmic sequestration of protein - cytoplasmic storage of protein - maintenance of protein location in cytoplasm - retention of protein in cytoplasm - sequestering of protein in cytoplasm - sequestration of protein in cytoplasm - storage of protein in cytoplasm - - - - GOC:dph - GOC:tb - maintenance of protein location in cytoplasm - - - - - GOC:ai - The selective interaction of a protein with specific molecules in the cytoplasm, thereby inhibiting its transport into other areas of the cell. - - - - - - - - - - positive regulation of protein transport - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GO:0051222 - activation of protein transport - biological_process - stimulation of protein transport - up regulation of protein transport - up-regulation of protein transport - upregulation of protein transport - - - - Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:ai - - - - - - - - - - regulation of protein transport - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GO:0051223 - biological_process - - - - Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:ai - - - - - - - - - - negative regulation of protein transport - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GO:0051224 - biological_process - down regulation of protein transport - down-regulation of protein transport - downregulation of protein transport - inhibition of protein transport - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:ai - - - - - - - - - - establishment of localization - - GO:0051234 - The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location. - biological_process - establishment of localisation - - - - - - GOC:mah - establishment of localisation - - - - - GOC:ai - The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location. - - - - - - - - - - maintenance of location - - - Any process in which a cell, substance or cellular entity, such as a protein complex or organelle, is maintained in a location and prevented from moving elsewhere. - GO:0051235 - biological_process - retention - sequestering - storage - - - - - Any process in which a cell, substance or cellular entity, such as a protein complex or organelle, is maintained in a location and prevented from moving elsewhere. - GOC:ai - GOC:dph - GOC:tb - - - - - - - - - - regulation of RNA metabolic process - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA. - GO:0051252 - biological_process - regulation of RNA metabolism - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA. - GOC:ai - - - - - - - - - - negative regulation of RNA metabolic process - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA. - GO:0051253 - biological_process - down regulation of RNA metabolic process - down-regulation of RNA metabolic process - downregulation of RNA metabolic process - inhibition of RNA metabolic process - negative regulation of RNA metabolism - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA. - GOC:ai - - - - - - - - - - positive regulation of RNA metabolic process - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA. - GO:0051254 - activation of RNA metabolic process - biological_process - positive regulation of RNA metabolism - stimulation of RNA metabolic process - up regulation of RNA metabolic process - up-regulation of RNA metabolic process - upregulation of RNA metabolic process - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA. - GOC:ai - - - - - - - - - - chromosome organization - - A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome. - GO:0007001 - GO:0051276 - GO:0051277 - biological_process - chromosome organisation - chromosome organization and biogenesis - maintenance of genome integrity - nuclear genome maintenance - - - - - - - - - A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome. - GOC:ai - GOC:dph - GOC:jl - GOC:mah - - - - - GOC:mah - chromosome organization and biogenesis - - - - - - - - - - centrosome organization - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. - GO:0051297 - biological_process - centrosome organisation - centrosome organization and biogenesis - - - - GOC:curators - centrosome organisation - - - - - GOC:mah - centrosome organization and biogenesis - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. - GOC:ai - GOC:dph - GOC:jl - GOC:mah - - - - - - - - - - centrosome duplication - - - - - - - - - - GO:0051298 - The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. - biological_process - centrosome replication - - - - GOC:ai - The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. - - - - - - - - - - cell division - - GO:0051301 - Note that this term differs from 'cytokinesis ; GO:0000910' in that cytokinesis does not include nuclear division. - The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. - Wikipedia:Cell_division - biological_process - - - - - - - - - GOC:di - GOC:go_curators - GOC:pr - The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. - - - - - - - - - - establishment of chromosome localization - - - - GO:0051303 - The directed movement of a chromosome to a specific location. - biological_process - chromosome positioning - establishment of chromosome localisation - - - - GOC:mah - establishment of chromosome localisation - - - - - GOC:ai - The directed movement of a chromosome to a specific location. - - - - - - - - - - metaphase plate congression - - - - - - - - GO:0051310 - The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the spindle. - biological_process - chromosome congression - - - - GOC:ascb_2009 - GOC:dph - GOC:tb - chromosome congression - - - - - GOC:ai - The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the spindle. - - - - - - - - - - chromosome decondensation - - GO:0051312 - The alteration of chromosome structure from the condensed form to a relaxed disperse form. - biological_process - - - - GOC:ai - The alteration of chromosome structure from the condensed form to a relaxed disperse form. - - - - - - - - - - G1 phase - - - - - - - - GO:0051318 - Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). - The cell cycle 'gap' phase which is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis. - Wikipedia:G1_phase - biological_process - - - - - GOC:mtg_cell_cycle - The cell cycle 'gap' phase which is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis. - - - - - - - - - - G2 phase - - - - - - - - GO:0051319 - Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). - The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis). - Wikipedia:G2_phase - biological_process - - - - - GOC:mtg_cell_cycle - The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis). - - - - - - - - - - S phase - - - - - - - - GO:0051320 - Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). - S-phase - The cell cycle phase, following G1, during which DNA synthesis takes place. - Wikipedia:S_phase - biological_process - - - - - GOC:mtg_cell_cycle - The cell cycle phase, following G1, during which DNA synthesis takes place. - - - - - - - - - - anaphase - - - - - - - - GO:0051322 - Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). - The cell cycle phase, following metaphase, during which the chromosomes separate and migrate towards the poles of the spindle. - Wikipedia:Anaphase - biological_process - - - - - GOC:mtg_cell_cycle - The cell cycle phase, following metaphase, during which the chromosomes separate and migrate towards the poles of the spindle. - - - - - - - - - - metaphase - - - - - - - - GO:0051323 - Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). - The cell cycle phase, following prophase or prometaphase in higher eukaryotes, during which chromosomes become aligned on the equatorial plate of the cell. - Wikipedia:Metaphase - biological_process - - - - - GOC:mtg_cell_cycle - The cell cycle phase, following prophase or prometaphase in higher eukaryotes, during which chromosomes become aligned on the equatorial plate of the cell. - - - - - - - - - - prophase - - - - - - - - GO:0051324 - Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). - The cell cycle phase which is the first stage of M phase of meiosis and mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell. - Wikipedia:Prophase - biological_process - - - - - GOC:mtg_cell_cycle - The cell cycle phase which is the first stage of M phase of meiosis and mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell. - - - - - - - - - - interphase - - GO:0051325 - Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). - The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when prophase of meiosis or mitosis begins. During interphase the cell readies itself for meiosis or mitosis and the replication of its DNA occurs. - Wikipedia:Interphase - biological_process - karyostasis - resting phase - - - - - GOC:mtg_cell_cycle - The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when prophase of meiosis or mitosis begins. During interphase the cell readies itself for meiosis or mitosis and the replication of its DNA occurs. - - - - - - - - - - telophase - - - - - - - - GO:0051326 - The cell cycle phase which follows anaphase during M phase of mitosis and meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts. - Wikipedia:Telophase - biological_process - note that this term should not be used for direct annotation. if you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic s-phase). to capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). - - - - - GOC:mtg_cell_cycle - The cell cycle phase which follows anaphase during M phase of mitosis and meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts. - - - - - - - - - - mitotic interphase - - - - - - - - - GO:0051329 - Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). - The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when mitotic prophase begins. During interphase the cell readies itself for mitosis and the replication of its DNA occurs. - biological_process - interphase of mitotic cell cycle - - - - - GOC:mtg_cell_cycle - The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when mitotic prophase begins. During interphase the cell readies itself for mitosis and the replication of its DNA occurs. - - - - - - - - - - organelle localization - - Any process in which an organelle is transported to, and/or maintained in, a specific location. - GO:0051640 - biological_process - establishment and maintenance of organelle localization - organelle localisation - - - - - Any process in which an organelle is transported to, and/or maintained in, a specific location. - GOC:ai - - - - - GOC:mah - organelle localisation - - - - - - - - - - cellular localization - - A localization process that takes place at the cellular level; as a result of a cellular localization process, a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell. - GO:0051641 - biological_process - cellular localisation - establishment and maintenance of cellular localization - establishment and maintenance of localization in cell or cell membrane - intracellular localization - localization within cell - - - - - - GOC:mah - cellular localisation - - - - - A localization process that takes place at the cellular level; as a result of a cellular localization process, a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell. - GOC:ai - GOC:mah - - - - - - - - - - establishment of localization in cell - - - - - - - - - - - - - - - - - - - - - - - - - GO:0051649 - The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell. - biological_process - establishment of cellular localization - establishment of intracellular localization - establishment of localisation in cell - establishment of localization within cell - positioning within cell - - - - - GOC:dph - GOC:tb - establishment of cellular localization - - - - - GOC:mah - establishment of localisation in cell - - - - - GOC:ai - GOC:dph - GOC:tb - The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell. - - - - - - - - - - maintenance of location in cell - - - - - - - - - - Any process in which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere. - GO:0051651 - biological_process - cellular retention - cellular sequestering - cellular storage - intracellular retention - intracellular sequestering - intracellular storage - maintenance of cellular localization - maintenance of intracellular localization - maintenance of localization in cell - maintenance of localization within cell - retention within cell - sequestering within cell - storage within cell - - - - - GOC:dph - GOC:tb - maintenance of cellular localization - - - - - Any process in which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere. - GOC:ai - - - - - GOC:dph - GOC:tb - maintenance of localization in cell - - - - - - - - - - establishment of organelle localization - - - - - - - - GO:0051656 - The directed movement of an organelle to a specific location. - biological_process - establishment of organelle localisation - - - - GOC:ai - The directed movement of an organelle to a specific location. - - - - - GOC:mah - establishment of organelle localisation - - - - - - - - - - localization of cell - - Any process in which a cell is transported to, and/or maintained in, a specific location. - GO:0051674 - biological_process - cell localization - establishment and maintenance of cell localization - establishment and maintenance of localization of cell - localisation of cell - - - - - GOC:mah - localisation of cell - - - - - Any process in which a cell is transported to, and/or maintained in, a specific location. - GOC:ai - - - - - - - - - - cellular response to stimulus - - - Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell. - GO:0051716 - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - biological_process - - - - - - Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell. - GOC:bf - GOC:jl - - - - - - - - - - regulation of macromolecule metabolic process - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - GO:0060255 - biological_process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - GOC:dph - GOC:tb - - - - - - - - - - regulation of cellular localization - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell. - GO:0060341 - biological_process - regulation of cellular localisation - - - - Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell. - GOC:dph - GOC:tb - - - - - GOC:mah - regulation of cellular localisation - - - - - - - - - - developmental growth involved in morphogenesis - - - - - - - - - - - - - - - - - - - 2009-04-28T08:42:53Z - GO:0060560 - The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape. - biological_process - differential growth - dph - - - - GOC:dph - The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape. - - - - - GOC:dph - differential growth - - - - - - - - - - membrane organization - - 2010-02-08T02:43:11Z - A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. - GO:0016044 - GO:0061024 - Reactome:REACT_101524 - Reactome:REACT_103082 - Reactome:REACT_11123 - Reactome:REACT_29278 - Reactome:REACT_32337 - Reactome:REACT_33741 - Reactome:REACT_34084 - Reactome:REACT_78213 - Reactome:REACT_78288 - Reactome:REACT_83546 - Reactome:REACT_86557 - Reactome:REACT_87431 - Reactome:REACT_88307 - Reactome:REACT_91154 - Reactome:REACT_93714 - Reactome:REACT_95586 - Reactome:REACT_96516 - Reactome:REACT_97881 - biological_process - cellular membrane organisation - cellular membrane organization - dph - membrane organisation - membrane organization and biogenesis - - - - - - - Membrane Trafficking, Rattus norvegicus - Reactome:REACT_97881 - - - - - Membrane Trafficking, Dictyostelium discoideum - Reactome:REACT_101524 - - - - - GOC:mah - membrane organization and biogenesis - - - - - Membrane Trafficking, Homo sapiens - Reactome:REACT_11123 - - - - - Membrane Trafficking, Oryza sativa - Reactome:REACT_83546 - - - - - Membrane Trafficking, Caenorhabditis elegans - Reactome:REACT_34084 - - - - - Membrane Trafficking, Schizosaccharomyces pombe - Reactome:REACT_103082 - - - - - Membrane Trafficking, Arabidopsis thaliana - Reactome:REACT_86557 - - - - - Membrane Trafficking, Plasmodium falciparum - Reactome:REACT_78213 - - - - - Membrane Trafficking, Taeniopygia guttata - Reactome:REACT_32337 - - - - - Membrane Trafficking, Bos taurus - Reactome:REACT_33741 - - - - - Membrane Trafficking, Gallus gallus - Reactome:REACT_95586 - - - - - GOC:mah - membrane organisation - - - - - Membrane Trafficking, Saccharomyces cerevisiae - Reactome:REACT_91154 - - - - - A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. - GOC:dph - GOC:tb - - - - - Membrane Trafficking, Mus musculus - Reactome:REACT_88307 - - - - - Membrane Trafficking, Xenopus tropicalis - Reactome:REACT_78288 - - - - - Membrane Trafficking, Danio rerio - Reactome:REACT_93714 - - - - - Membrane Trafficking, Sus scrofa - Reactome:REACT_29278 - - - - - Membrane Trafficking, Canis familiaris - Reactome:REACT_96516 - - - - - Membrane Trafficking, Drosophila melanogaster - Reactome:REACT_87431 - - - - - GOC:curators - cellular membrane organisation - - - - - - - - - - membrane fusion - - 2010-02-08T02:48:06Z - GO:0006944 - GO:0061025 - The membrane organization process that joins two lipid bilayers to form a single membrane. - Wikipedia:Lipid_bilayer_fusion - biological_process - cellular membrane fusion - dph - - - - - GOC:dph - GOC:tb - The membrane organization process that joins two lipid bilayers to form a single membrane. - - - - - - - - - - endoplasmic reticulum polarization - - - - 2010-06-25T09:51:48Z - GO:0061163 - The endoplasmic reticulum organization process that results in the structure of the endoplasmic reticulum being oriented in the cell. - biological_process - dph - - - - GOC:dph - GOC:vw - The endoplasmic reticulum organization process that results in the structure of the endoplasmic reticulum being oriented in the cell. - - - - - - - - - - biological regulation - - Any process that modulates a measurable attribute of any biological process, quality or function. - GO:0065007 - biological_process - regulation - - - - - - Any process that modulates a measurable attribute of any biological process, quality or function. - GOC:dph - GOC:isa_complete - GOC:mah - GOC:pr - GOC:vw - - - - - - - - - - regulation of biological quality - - Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc. - GO:0065008 - biological_process - regulation of biological attribute - regulation of biological characteristic - - - - - Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc. - GOC:dph - GOC:isa_complete - GOC:mah - GOC:pr - GOC:vw - - - - - - - - - - regulation of molecular function - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. - GO:0065009 - biological_process - regulation of a molecular function - - - - - Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. - GOC:isa_complete - - - - - - - - - - intracellular organelle lumen - - - An organelle lumen that is part of an intracellular organelle. - GO:0070013 - cellular_component - - - - An organelle lumen that is part of an intracellular organelle. - GOC:mah - - - - - - - - - - anchoring junction - - A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. - GO:0070161 - anchoring cell junction - cellular_component - - - - A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. - ISBN:0815332181 - - - - - GOC:mah - anchoring cell junction - - - - - - - - - - regulation of establishment of protein localization - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location. - GO:0070201 - biological_process - regulation of establishment of protein localisation - - - - Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location. - GOC:BHF - GOC:mah - - - - - GOC:mah - regulation of establishment of protein localisation - - - - - - - - - - actin-mediated cell contraction - - GO:0070252 - The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body. - biological_process - - - - GOC:mah - The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body. - - - - - - - - - - protein localization to mitochondrion - - 2009-04-24T02:31:18Z - A process in which a protein is transported to, or maintained in, a location within the mitochondrion. - GO:0070585 - biological_process - midori - protein localisation in mitochondrion - protein localization in mitochondrion - - - - GOC:curators - protein localization in mitochondrion - - - - - A process in which a protein is transported to, or maintained in, a location within the mitochondrion. - GOC:ecd - - - - - GOC:mah - protein localisation in mitochondrion - - - - - - - - - - cellular macromolecule localization - - - 2009-06-16T04:08:29Z - Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. - GO:0070727 - biological_process - cellular macromolecule localisation - midori - - - - GOC:mah - cellular macromolecule localisation - - - - - Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. - GOC:mah - - - - - - - - - - cellular response to chemical stimulus - - - 2009-08-27T04:41:45Z - Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus. - GO:0070887 - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - biological_process - midori - - - - - Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus. - GOC:mah - - - - - - - - - - organelle assembly - - - 2009-09-15T03:00:51Z - GO:0070925 - The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. - biological_process - midori - - - - - GOC:mah - The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. - - - - - - - - - - protein localization to endoplasmic reticulum - - 2009-10-02T12:43:34Z - A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum. - GO:0070972 - biological_process - midori - protein localisation in endoplasmic reticulum - protein localization in ER - protein localization in endoplasmic reticulum - - - - A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum. - GOC:mah - - - - - GOC:mah - protein localization in ER - - - - - GOC:curators - protein localization in endoplasmic reticulum - - - - - GOC:mah - protein localisation in endoplasmic reticulum - - - - - - - - - - DNA conformation change - - 2009-11-09T11:36:34Z - A cellular process that results in a change in the spatial configuration of a DNA molecule. A conformation change can bend DNA, or alter the, twist, writhe, or linking number of a DNA molecule. - DNA conformation modification - GO:0071103 - biological_process - midori - - - - - A cellular process that results in a change in the spatial configuration of a DNA molecule. A conformation change can bend DNA, or alter the, twist, writhe, or linking number of a DNA molecule. - GOC:mah - - - - - DNA conformation modification - GOC:mah - - - - - - - - - - protein localization to centrosome - - 2010-01-12T02:09:45Z - A process in which a protein is transported to, or maintained at, the centrosome. - GO:0071539 - biological_process - midori - protein localisation to centrosome - - - - A process in which a protein is transported to, or maintained at, the centrosome. - GOC:ecd - - - - - GOC:mah - protein localisation to centrosome - - - - - - - - - - organic substance transport - - 2010-03-08T02:15:14Z - GO:0071702 - The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon. - biological_process - midori - - - - CHEBI:50860 - GOC:mah - The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon. - - - - - - - - - - organic substance metabolic process - - 2010-03-08T03:32:18Z - GO:0071704 - The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon. - biological_process - midori - organic molecular entity metabolic process - organic molecular entity metabolism - organic substance metabolism - - - - CHEBI:50860 - GOC:mah - The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon. - - - - - - - - - - nitrogen compound transport - - 2010-03-08T03:56:28Z - GO:0071705 - The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - biological_process - midori - - - - CHEBI:51143 - GOC:mah - The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - - - - - - - - - - cellular component organization or biogenesis - - 2010-09-10T01:39:16Z - A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component. - GO:0071840 - GO:0071841 - biological_process - cellular component organisation or biogenesis - cellular component organisation or biogenesis at cellular level - cellular component organization or biogenesis at cellular level - midori - - - - GOC:mah - cellular component organisation or biogenesis - - - - - A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component. - GOC:mah - - - - - GOC:mah - cellular component organisation or biogenesis at cellular level - - - - - - - - - - DNA biosynthetic process - - - - 2010-09-15T02:14:33Z - DNA anabolism - DNA biosynthesis - DNA formation - DNA synthesis - GO:0071897 - The cellular DNA metabolic process resulting in the formation of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. - biological_process - midori - - - - - GOC:mah - The cellular DNA metabolic process resulting in the formation of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. - - - - - DNA formation - GOC:mah - - - - - DNA biosynthesis - GOC:mah - - - - - DNA synthesis - GOC:mah - - - - - DNA anabolism - GOC:mah - - - - - - - - - - cell periphery - - 2010-10-04T01:51:47Z - GO:0071944 - The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures. - cellular_component - midori - - - - GOC:mah - The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures. - - - - - - - - - - establishment of protein localization to organelle - - - - - - - - 2011-02-14T01:56:51Z - GO:0072594 - The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle. - biological_process - establishment of protein localisation to organelle - midori - - - - GOC:mah - establishment of protein localisation to organelle - - - - - GOC:mah - The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle. - - - - - - - - - - protein localization to membrane - - - - 2011-02-14T02:35:18Z - A process in which a protein is transported to, or maintained in, a specific location in a membrane. - GO:0072657 - biological_process - midori - protein localisation in membrane - protein localization in membrane - - - - GOC:mah - protein localisation in membrane - - - - - GOC:curators - protein localization in membrane - - - - - A process in which a protein is transported to, or maintained in, a specific location in a membrane. - GOC:mah - - - - - - - - - - protein localization to plasma membrane - - - 2011-02-14T02:43:05Z - A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. - GO:0072659 - biological_process - midori - protein localisation in plasma membrane - protein localization in plasma membrane - - - - GOC:mah - protein localisation in plasma membrane - - - - - GOC:curators - protein localization in plasma membrane - - - - - A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. - GOC:mah - - - - - - - - - - protein localization to peroxisome - - - - - 2011-02-14T02:50:04Z - A process in which a protein is transported to, or maintained at, a location in a peroxisome. - GO:0072662 - biological_process - midori - protein localisation to peroxisome - - - - A process in which a protein is transported to, or maintained at, a location in a peroxisome. - GOC:ecd - - - - - GOC:mah - protein localisation to peroxisome - - - - - - - - - - protein localization to vacuole - - 2011-02-14T02:55:35Z - A process in which a protein is transported to, or maintained at, a location in a vacuole. - GO:0072665 - biological_process - midori - protein localisation to vacuole - - - - GOC:mah - protein localisation to vacuole - - - - - A process in which a protein is transported to, or maintained at, a location in a vacuole. - GOC:ecd - - - - - - - - - - protein localization to microtubule cytoskeleton - - 2012-04-11T01:19:35Z - A cellular protein localization process in which a protein is transported to, or maintained at, a location within the microtubule cytoskeleton. - GO:0072698 - biological_process - midori - protein localisation to microtubule cytoskeleton - - - - A cellular protein localization process in which a protein is transported to, or maintained at, a location within the microtubule cytoskeleton. - GOC:mah - - - - - GOC:mah - protein localisation to microtubule cytoskeleton - - - - - - - - - - regulation of primary metabolic process - - - - - - - - - - - - - - - - - - - 2009-04-22T04:30:52Z - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. - GO:0080090 - biological_process - donghui - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. - PMID:19211694 - - - - - - - - - - regulation of peptide transport - - - - - - - - - - - - - - - - - - - 2009-10-23T11:21:38Z - Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GO:0090087 - biological_process - tanyaberardini - - - - Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:dph - GOC:tb - - - - - - - - - - membrane fission - - 2009-12-08T03:06:36Z - A process that is carried out at the cellular level which results in the separation of a single continuous membrane into two membranes. - GO:0090148 - biological_process - tanyaberardini - - - - A process that is carried out at the cellular level which results in the separation of a single continuous membrane into two membranes. - GOC:ascb_2009 - GOC:dph - GOC:tb - - - - - - - - - - protein localization to nuclear pore - - - 2009-12-18T12:05:01Z - A process in which a protein is transported to, or maintained in, a nuclear pore. - GO:0090204 - biological_process - protein localisation to nuclear pore - tanyaberardini - - - - A process in which a protein is transported to, or maintained in, a nuclear pore. - GOC:dph - GOC:rb - GOC:tb - - - - - GOC:mah - protein localisation to nuclear pore - - - - - - - - - - nucleic acid metabolic process - - - 2010-04-07T10:18:47Z - Any cellular metabolic process involving nucleic acids. - GO:0090304 - biological_process - tanyaberardini - - - - Any cellular metabolic process involving nucleic acids. - GOC:dph - GOC:tb - - - - - - - - - - nucleic acid phosphodiester bond hydrolysis - - 2010-04-07T10:26:30Z - GO:0090305 - The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis. - biological_process - nucleic acid cleavage - tanyaberardini - - - - GOC:dph - GOC:tb - nucleic acid cleavage - - - - - GOC:dph - GOC:tb - The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis. - - - - - - - - - - positive regulation of intracellular protein transport - - - - - - - - - - - - - - - - - - - - - - 2010-04-16T03:45:07Z - Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells. - GO:0090316 - biological_process - tanyaberardini - - - - Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells. - GOC:tb - - - - - - - - - - negative regulation of intracellular protein transport - - - - - - - - - - - - - - - - - - - - - - 2010-04-16T03:45:07Z - Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells. - GO:0090317 - biological_process - tanyaberardini - - - - Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells. - GOC:tb - - - - - - - - - - protein localization to nuclear envelope - - - - - - - - 2012-07-30T01:50:41Z - A process in which a protein is transported to, or maintained at, a location within a nuclear envelope. - GO:0090435 - biological_process - protein localization in nuclear envelope - tanyaberardini - - - - A process in which a protein is transported to, or maintained at, a location within a nuclear envelope. - GOC:tb - - - - - GOC:curators - protein localization in nuclear envelope - - - - - - - - - - organic cyclic compound binding - - 2011-09-23T02:31:01Z - GO:0097159 - Interacting selectively and non-covalently with an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure. - molecular_function - paola - - - - CHEBI:33832 - GOC:sjw - Interacting selectively and non-covalently with an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure. - PMID:7583672 - - - - - - - - - - execution phase of apoptosis - - - - - - - - - - - - - - 2011-11-23T09:45:24Z - A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. - GO:0097194 - apoptosis - biological_process - execution phase of apoptotic process - paola - - - - A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. - GOC:mtg_apoptosis - PMID:21760595 - - - - - - - - - - protein localization to bud neck - - 2012-03-20T03:39:20Z - A process in which a protein is transported to, or maintained at, a location within a cellular bud neck. - GO:0097271 - biological_process - paola - protein localisation to bud neck - protein localization to cellular bud neck - - - - A process in which a protein is transported to, or maintained at, a location within a cellular bud neck. - GOC:rb - PMID:22344253 - - - - - GOC:mah - protein localisation to bud neck - - - - - - - - - - microtubule bundle - - - - - - - - 2012-11-07T15:01:27Z - An arrangement of closely apposed microtubules running parallel to each other. - GO:0097427 - NIF_Subcellular:sao1872343973 - cellular_component - microtubule fascicle - paola - - - - An arrangement of closely apposed microtubules running parallel to each other. - NIF_Subcellular:sao1872343973 - - - - - - - - - - neuron part - - 2012-12-19T16:53:50Z - Any constituent part of a neuron, the basic cellular unit of nervous tissue. A typical neuron consists of a cell body (often called the soma), an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. - GO:0097458 - cellular_component - paola - - - - - - Any constituent part of a neuron, the basic cellular unit of nervous tissue. A typical neuron consists of a cell body (often called the soma), an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. - GOC:pr - http://en.wikipedia.org/wiki/Neuron - - - - - - - - - - nucleic acid-templated transcription - - 2014-10-01T13:49:27Z - GO:0097659 - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - The cellular synthesis of RNA on a template of nucleic acid (DNA or RNA). - biological_process - paola - - - - - GOC:pr - GOC:txnOH - GOC:vw - The cellular synthesis of RNA on a template of nucleic acid (DNA or RNA). - - - - - - - - - - centriole assembly - - - - 2013-10-22T15:55:22Z - A cellular process that results in the assembly of one or more centrioles. - GO:0098534 - biological_process - davidos - - - - A cellular process that results in the assembly of one or more centrioles. - GOC:dos - PMID:24075808 - - - - - - - - - - single organism cell adhesion - - - 2014-04-15T15:59:10Z - GO:0098602 - The attachment, via cell adhesion molecules, of a cell to either another cell of the same organism, or to an underlying substrate of the same organism such as the extracellular matrix. - biological_process - davidos - - - - GOC:dos - The attachment, via cell adhesion molecules, of a cell to either another cell of the same organism, or to an underlying substrate of the same organism such as the extracellular matrix. - - - - - - - - - - chromosomal region - - Any subdivision of a chromosome along its length. - Chromosomal regions include parts that are not part of the chromatin. Examples include the kinetochore. - GO:0098687 - cellular_component - chromosome region - - - - Any subdivision of a chromosome along its length. - GOC:dos - - - - - - - - - - mitotic cell cycle phase - - - - - - - - - - - - - - - - - - - GO:0098763 - One of the distinct periods or stages into which the mitotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events. - biological_process - - - - GOC:dos - One of the distinct periods or stages into which the mitotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events. - - - - - - - - - - nuclear chromosome segregation - - - - - - - - - GO:0098813 - The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. - biological_process - - - - GOC:dos - The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. - - - - - - - - - - regulation of protein localization to nucleus - - - - - - - - - - - - - - - - - - - 2012-03-12T01:23:44Z - Any process that modulates the frequency, rate or extent of protein localization to nucleus. - GO:1900180 - bf - biological_process - regulation of protein localisation to nucleus - regulation of protein localization in cell nucleus - regulation of protein localization in nucleus - - - - GOC:TermGenie - regulation of protein localization in cell nucleus - - - - - GOC:TermGenie - regulation of protein localisation to nucleus - - - - - GOC:TermGenie - regulation of protein localization in nucleus - - - - - Any process that modulates the frequency, rate or extent of protein localization to nucleus. - GOC:TermGenie - - - - - - - - - - negative regulation of protein localization to nucleus - - - - - - - - - - - - - - - - - - - - - 2012-03-12T01:23:48Z - Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus. - GO:1900181 - bf - biological_process - down regulation of protein localisation to nucleus - down regulation of protein localization in cell nucleus - down regulation of protein localization in nucleus - down regulation of protein localization to nucleus - down-regulation of protein localisation to nucleus - down-regulation of protein localization in cell nucleus - down-regulation of protein localization in nucleus - down-regulation of protein localization to nucleus - downregulation of protein localisation to nucleus - downregulation of protein localization in cell nucleus - downregulation of protein localization in nucleus - downregulation of protein localization to nucleus - inhibition of protein localisation to nucleus - inhibition of protein localization in cell nucleus - inhibition of protein localization in nucleus - inhibition of protein localization to nucleus - negative regulation of protein localisation to nucleus - negative regulation of protein localization in cell nucleus - negative regulation of protein localization in nucleus - - - - GOC:TermGenie - inhibition of protein localization in cell nucleus - - - - - GOC:TermGenie - down regulation of protein localisation to nucleus - - - - - GOC:TermGenie - negative regulation of protein localization in nucleus - - - - - GOC:TermGenie - down-regulation of protein localization in nucleus - - - - - GOC:TermGenie - negative regulation of protein localisation to nucleus - - - - - GOC:TermGenie - inhibition of protein localization to nucleus - - - - - GOC:TermGenie - negative regulation of protein localization in cell nucleus - - - - - GOC:TermGenie - downregulation of protein localisation to nucleus - - - - - GOC:TermGenie - down regulation of protein localization to nucleus - - - - - GOC:TermGenie - downregulation of protein localization in cell nucleus - - - - - GOC:TermGenie - inhibition of protein localisation to nucleus - - - - - GOC:TermGenie - down regulation of protein localization in nucleus - - - - - GOC:TermGenie - down-regulation of protein localisation to nucleus - - - - - GOC:TermGenie - downregulation of protein localization to nucleus - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus. - GOC:TermGenie - - - - - GOC:TermGenie - down regulation of protein localization in cell nucleus - - - - - GOC:TermGenie - inhibition of protein localization in nucleus - - - - - GOC:TermGenie - down-regulation of protein localization in cell nucleus - - - - - GOC:TermGenie - down-regulation of protein localization to nucleus - - - - - GOC:TermGenie - downregulation of protein localization in nucleus - - - - - - - - - - positive regulation of protein localization to nucleus - - - - - - - - - - - - - - - - - - - - - 2012-03-12T01:23:52Z - Any process that activates or increases the frequency, rate or extent of protein localization to nucleus. - GO:1900182 - activation of protein localisation to nucleus - activation of protein localization in cell nucleus - activation of protein localization in nucleus - activation of protein localization to nucleus - bf - biological_process - positive regulation of protein localisation to nucleus - positive regulation of protein localization in cell nucleus - positive regulation of protein localization in nucleus - up regulation of protein localisation to nucleus - up regulation of protein localization in cell nucleus - up regulation of protein localization in nucleus - up regulation of protein localization to nucleus - up-regulation of protein localisation to nucleus - up-regulation of protein localization in cell nucleus - up-regulation of protein localization in nucleus - up-regulation of protein localization to nucleus - upregulation of protein localisation to nucleus - upregulation of protein localization in cell nucleus - upregulation of protein localization in nucleus - upregulation of protein localization to nucleus - - - - GOC:TermGenie - activation of protein localization in cell nucleus - - - - - GOC:TermGenie - up-regulation of protein localization in cell nucleus - - - - - GOC:TermGenie - up-regulation of protein localization in nucleus - - - - - GOC:TermGenie - up regulation of protein localization to nucleus - - - - - GOC:TermGenie - positive regulation of protein localisation to nucleus - - - - - GOC:TermGenie - activation of protein localization in nucleus - - - - - GOC:TermGenie - up-regulation of protein localization to nucleus - - - - - GOC:TermGenie - upregulation of protein localization in cell nucleus - - - - - GOC:TermGenie - up regulation of protein localization in cell nucleus - - - - - GOC:TermGenie - up regulation of protein localization in nucleus - - - - - Any process that activates or increases the frequency, rate or extent of protein localization to nucleus. - GOC:TermGenie - - - - - GOC:TermGenie - upregulation of protein localization to nucleus - - - - - GOC:TermGenie - up regulation of protein localisation to nucleus - - - - - GOC:TermGenie - upregulation of protein localization in nucleus - - - - - GOC:TermGenie - positive regulation of protein localization in cell nucleus - - - - - GOC:TermGenie - upregulation of protein localisation to nucleus - - - - - GOC:TermGenie - positive regulation of protein localization in nucleus - - - - - GOC:TermGenie - up-regulation of protein localisation to nucleus - - - - - GOC:TermGenie - activation of protein localisation to nucleus - - - - - GOC:TermGenie - activation of protein localization to nucleus - - - - - - - - - - organic cyclic compound metabolic process - - 2012-09-14T09:03:51Z - GO:1901360 - The chemical reactions and pathways involving organic cyclic compound. - bf - biological_process - organic cyclic compound metabolism - - - - GOC:TermGenie - organic cyclic compound metabolism - - - - - GOC:TermGenie - The chemical reactions and pathways involving organic cyclic compound. - - - - - - - - - - organic cyclic compound catabolic process - - - 2012-09-14T09:05:04Z - GO:1901361 - The chemical reactions and pathways resulting in the breakdown of organic cyclic compound. - bf - biological_process - organic cyclic compound breakdown - organic cyclic compound catabolism - organic cyclic compound degradation - - - - GOC:TermGenie - organic cyclic compound breakdown - - - - - GOC:TermGenie - organic cyclic compound degradation - - - - - GOC:TermGenie - The chemical reactions and pathways resulting in the breakdown of organic cyclic compound. - - - - - GOC:TermGenie - organic cyclic compound catabolism - - - - - - - - - - organic cyclic compound biosynthetic process - - - 2012-09-14T09:05:22Z - GO:1901362 - The chemical reactions and pathways resulting in the formation of organic cyclic compound. - bf - biological_process - organic cyclic compound anabolism - organic cyclic compound biosynthesis - organic cyclic compound formation - organic cyclic compound synthesis - - - - GOC:TermGenie - organic cyclic compound anabolism - - - - - GOC:TermGenie - organic cyclic compound biosynthesis - - - - - GOC:TermGenie - organic cyclic compound formation - - - - - GOC:TermGenie - organic cyclic compound synthesis - - - - - GOC:TermGenie - The chemical reactions and pathways resulting in the formation of organic cyclic compound. - - - - - - - - - - heterocyclic compound binding - - 2012-09-14T13:53:50Z - GO:1901363 - Interacting selectively and non-covalently with heterocyclic compound. - bf - molecular_function - - - - GOC:TermGenie - Interacting selectively and non-covalently with heterocyclic compound. - - - - - - - - - - organic substance catabolic process - - - 2012-11-05T11:04:36Z - GO:1901575 - The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon. - biological_process - organic molecular entity breakdown - organic molecular entity catabolic process - organic molecular entity catabolism - organic molecular entity degradation - organic substance breakdown - organic substance catabolism - organic substance degradation - pr - - - - GOC:TermGenie - organic molecular entity degradation - - - - - GOC:TermGenie - organic molecular entity breakdown - - - - - GOC:TermGenie - organic molecular entity catabolism - - - - - GOC:TermGenie - GOC:pr - The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon. - - - - - - - - - - organic substance biosynthetic process - - - 2012-11-05T11:04:40Z - GO:1901576 - The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon. - biological_process - organic molecular entity anabolism - organic molecular entity biosynthesis - organic molecular entity biosynthetic process - organic molecular entity formation - organic molecular entity synthesis - organic substance anabolism - organic substance biosynthesis - organic substance formation - organic substance synthesis - pr - - - - GOC:TermGenie - organic molecular entity biosynthesis - - - - - GOC:TermGenie - organic molecular entity anabolism - - - - - GOC:TermGenie - organic molecular entity formation - - - - - GOC:TermGenie - organic molecular entity synthesis - - - - - GOC:TermGenie - GOC:pr - The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon. - - - - - - - - - - regulation of intracellular signal transduction - - - - - - - - - - - - - - - - - - - 2013-12-02T11:32:52Z - Any process that modulates the frequency, rate or extent of intracellular signal transduction. - GO:0010627 - GO:1902531 - bf - biological_process - regulation of intracellular protein kinase cascade - regulation of intracellular signal transduction pathway - regulation of intracellular signaling cascade - regulation of intracellular signaling chain - regulation of intracellular signaling pathway - regulation of signal transduction via intracellular signaling cascade - regulation of signal transmission via intracellular cascade - - - - GOC:TermGenie - regulation of intracellular signal transduction pathway - - - - - GOC:TermGenie - regulation of signal transmission via intracellular cascade - - - - - Any process that modulates the frequency, rate or extent of intracellular signal transduction. - GOC:TermGenie - GOC:dph - GOC:signaling - GOC:tb - - - - - GOC:TermGenie - regulation of signal transduction via intracellular signaling cascade - - - - - GOC:TermGenie - regulation of intracellular signaling chain - - - - - GOC:TermGenie - regulation of intracellular signaling pathway - - - - - GOC:TermGenie - regulation of intracellular signaling cascade - - - - - - - - - - negative regulation of intracellular signal transduction - - - - - - - - - - - - - - - - - - - - 2013-12-02T11:33:01Z - Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction. - GO:0010741 - GO:1902532 - bf - biological_process - down regulation of intracellular signal transduction - down regulation of intracellular signal transduction pathway - down regulation of intracellular signaling cascade - down regulation of intracellular signaling chain - down regulation of intracellular signaling pathway - down regulation of signal transduction via intracellular signaling cascade - down regulation of signal transmission via intracellular cascade - down-regulation of intracellular signal transduction - down-regulation of intracellular signal transduction pathway - down-regulation of intracellular signaling cascade - down-regulation of intracellular signaling chain - down-regulation of intracellular signaling pathway - down-regulation of signal transduction via intracellular signaling cascade - down-regulation of signal transmission via intracellular cascade - downregulation of intracellular signal transduction - downregulation of intracellular signal transduction pathway - downregulation of intracellular signaling cascade - downregulation of intracellular signaling chain - downregulation of intracellular signaling pathway - downregulation of signal transduction via intracellular signaling cascade - downregulation of signal transmission via intracellular cascade - inhibition of intracellular signal transduction - inhibition of intracellular signal transduction pathway - inhibition of intracellular signaling cascade - inhibition of intracellular signaling chain - inhibition of intracellular signaling pathway - inhibition of signal transduction via intracellular signaling cascade - inhibition of signal transmission via intracellular cascade - negative regulation of intracellular protein kinase cascade - negative regulation of intracellular signal transduction pathway - negative regulation of intracellular signaling cascade - negative regulation of intracellular signaling chain - negative regulation of intracellular signaling pathway - negative regulation of signal transduction via intracellular signaling cascade - negative regulation of signal transmission via intracellular cascade - - - - GOC:TermGenie - down-regulation of signal transmission via intracellular cascade - - - - - GOC:TermGenie - down-regulation of intracellular signaling pathway - - - - - GOC:TermGenie - inhibition of intracellular signal transduction - - - - - GOC:TermGenie - downregulation of intracellular signal transduction - - - - - GOC:TermGenie - inhibition of intracellular signaling cascade - - - - - GOC:TermGenie - down regulation of intracellular signal transduction pathway - - - - - GOC:TermGenie - downregulation of intracellular signaling pathway - - - - - GOC:TermGenie - inhibition of intracellular signaling pathway - - - - - GOC:TermGenie - inhibition of intracellular signal transduction pathway - - - - - GOC:TermGenie - down regulation of intracellular signaling chain - - - - - GOC:TermGenie - downregulation of intracellular signal transduction pathway - - - - - GOC:TermGenie - down-regulation of intracellular signaling cascade - - - - - GOC:TermGenie - down-regulation of intracellular signaling chain - - - - - GOC:TermGenie - down regulation of intracellular signal transduction - - - - - GOC:TermGenie - negative regulation of intracellular signaling chain - - - - - GOC:TermGenie - negative regulation of signal transmission via intracellular cascade - - - - - GOC:TermGenie - inhibition of intracellular signaling chain - - - - - GOC:TermGenie - down regulation of intracellular signaling pathway - - - - - GOC:TermGenie - downregulation of signal transduction via intracellular signaling cascade - - - - - GOC:TermGenie - down-regulation of signal transduction via intracellular signaling cascade - - - - - GOC:TermGenie - down regulation of signal transmission via intracellular cascade - - - - - GOC:TermGenie - downregulation of intracellular signaling chain - - - - - GOC:TermGenie - inhibition of signal transduction via intracellular signaling cascade - - - - - GOC:TermGenie - negative regulation of signal transduction via intracellular signaling cascade - - - - - GOC:TermGenie - down regulation of intracellular signaling cascade - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction. - GOC:TermGenie - GOC:dph - GOC:signaling - GOC:tb - - - - - GOC:TermGenie - inhibition of signal transmission via intracellular cascade - - - - - GOC:TermGenie - negative regulation of intracellular signaling pathway - - - - - GOC:TermGenie - negative regulation of intracellular signaling cascade - - - - - GOC:TermGenie - down-regulation of intracellular signal transduction pathway - - - - - GOC:TermGenie - downregulation of signal transmission via intracellular cascade - - - - - GOC:TermGenie - down-regulation of intracellular signal transduction - - - - - GOC:TermGenie - negative regulation of intracellular signal transduction pathway - - - - - GOC:TermGenie - down regulation of signal transduction via intracellular signaling cascade - - - - - GOC:TermGenie - downregulation of intracellular signaling cascade - - - - - - - - - - positive regulation of intracellular signal transduction - - - - - - - - - - - - - - - - - - - - 2013-12-02T11:33:10Z - Any process that activates or increases the frequency, rate or extent of intracellular signal transduction. - GO:0010740 - GO:1902533 - activation of intracellular signal transduction - activation of intracellular signal transduction pathway - activation of intracellular signaling cascade - activation of intracellular signaling chain - activation of intracellular signaling pathway - activation of signal transduction via intracellular signaling cascade - activation of signal transmission via intracellular cascade - bf - biological_process - positive regulation of intracellular protein kinase cascade - positive regulation of intracellular signal transduction pathway - positive regulation of intracellular signaling cascade - positive regulation of intracellular signaling chain - positive regulation of intracellular signaling pathway - positive regulation of signal transduction via intracellular signaling cascade - positive regulation of signal transmission via intracellular cascade - up regulation of intracellular signal transduction - up regulation of intracellular signal transduction pathway - up regulation of intracellular signaling cascade - up regulation of intracellular signaling chain - up regulation of intracellular signaling pathway - up regulation of signal transduction via intracellular signaling cascade - up regulation of signal transmission via intracellular cascade - up-regulation of intracellular signal transduction - up-regulation of intracellular signal transduction pathway - up-regulation of intracellular signaling cascade - up-regulation of intracellular signaling chain - up-regulation of intracellular signaling pathway - up-regulation of signal transduction via intracellular signaling cascade - up-regulation of signal transmission via intracellular cascade - upregulation of intracellular signal transduction - upregulation of intracellular signal transduction pathway - upregulation of intracellular signaling cascade - upregulation of intracellular signaling chain - upregulation of intracellular signaling pathway - upregulation of signal transduction via intracellular signaling cascade - upregulation of signal transmission via intracellular cascade - - - - GOC:TermGenie - up regulation of intracellular signaling pathway - - - - - GOC:TermGenie - activation of signal transmission via intracellular cascade - - - - - GOC:TermGenie - activation of intracellular signal transduction pathway - - - - - GOC:TermGenie - upregulation of intracellular signal transduction pathway - - - - - GOC:TermGenie - upregulation of intracellular signaling cascade - - - - - GOC:TermGenie - up regulation of intracellular signaling chain - - - - - GOC:TermGenie - upregulation of signal transmission via intracellular cascade - - - - - GOC:TermGenie - up regulation of signal transduction via intracellular signaling cascade - - - - - GOC:TermGenie - activation of intracellular signaling pathway - - - - - GOC:TermGenie - up-regulation of signal transduction via intracellular signaling cascade - - - - - GOC:TermGenie - up-regulation of intracellular signaling pathway - - - - - GOC:TermGenie - positive regulation of intracellular signaling chain - - - - - GOC:TermGenie - upregulation of intracellular signal transduction - - - - - GOC:TermGenie - upregulation of signal transduction via intracellular signaling cascade - - - - - GOC:TermGenie - up regulation of signal transmission via intracellular cascade - - - - - GOC:TermGenie - positive regulation of signal transduction via intracellular signaling cascade - - - - - GOC:TermGenie - up-regulation of intracellular signal transduction pathway - - - - - GOC:TermGenie - upregulation of intracellular signaling pathway - - - - - GOC:TermGenie - upregulation of intracellular signaling chain - - - - - GOC:TermGenie - positive regulation of signal transmission via intracellular cascade - - - - - GOC:TermGenie - positive regulation of intracellular signaling cascade - - - - - GOC:TermGenie - activation of intracellular signaling chain - - - - - GOC:TermGenie - up-regulation of intracellular signal transduction - - - - - GOC:TermGenie - activation of signal transduction via intracellular signaling cascade - - - - - GOC:TermGenie - up-regulation of intracellular signaling chain - - - - - GOC:TermGenie - positive regulation of intracellular signal transduction pathway - - - - - GOC:TermGenie - up-regulation of intracellular signaling cascade - - - - - GOC:TermGenie - activation of intracellular signal transduction - - - - - Any process that activates or increases the frequency, rate or extent of intracellular signal transduction. - GOC:BHF - GOC:TermGenie - GOC:dph - GOC:signaling - GOC:tb - - - - - GOC:TermGenie - up regulation of intracellular signal transduction pathway - - - - - GOC:TermGenie - up regulation of intracellular signaling cascade - - - - - GOC:TermGenie - up-regulation of signal transmission via intracellular cascade - - - - - GOC:TermGenie - positive regulation of intracellular signaling pathway - - - - - GOC:TermGenie - up regulation of intracellular signal transduction - - - - - GOC:TermGenie - activation of intracellular signaling cascade - - - - - - - - - - protein localization to nucleolus - - 2013-12-10T16:25:28Z - A process in which a protein is transported to, or maintained in, a location within a nucleolus. - GO:1902570 - biological_process - mah - protein localisation in nucleolus - protein localisation to nucleolus - protein localization in nucleolus - - - - GOC:TermGenie - protein localization in nucleolus - - - - - GOC:TermGenie - protein localisation in nucleolus - - - - - GOC:TermGenie - protein localisation to nucleolus - - - - - A process in which a protein is transported to, or maintained in, a location within a nucleolus. - GOC:TermGenie - PMID:22809626 - - - - - - - - - - single-organism localization - - - 2013-12-18T13:51:04Z - A localization which involves only one organism. - GO:1902578 - biological_process - jl - single organism localization - - - - GOC:TermGenie - single organism localization - - - - - A localization which involves only one organism. - GOC:jl - GO_REF:0000089 - PMID:1234 - - - - - - - - - - single-organism cellular localization - - - 2013-12-18T14:04:32Z - A cellular localization which involves only one organism. - GO:1902580 - biological_process - jl - single organism cellular localization - - - - A cellular localization which involves only one organism. - GOC:TermGenie - GOC:jl - GO_REF:0000089 - - - - - GOC:TermGenie - single organism cellular localization - - - - - - - - - - single-organism intracellular transport - - - 2013-12-18T14:04:50Z - An intracellular transport which involves only one organism. - GO:1902582 - biological_process - jl - single organism intracellular transport - - - - GOC:TermGenie - single organism intracellular transport - - - - - An intracellular transport which involves only one organism. - GOC:TermGenie - GOC:jl - GO_REF:0000089 - - - - - - - - - - single-organism organelle organization - - - 2013-12-19T15:25:51Z - An organelle organization which involves only one organism. - GO:1902589 - biological_process - jl - single organism organelle organization - - - - An organelle organization which involves only one organism. - GOC:TermGenie - GOC:jl - GO_REF:0000089 - - - - - GOC:TermGenie - single organism organelle organization - - - - - - - - - - single-organism nuclear import - - - 2013-12-19T15:26:34Z - A nuclear import which involves only one organism. - GO:1902593 - biological_process - jl - single organism nuclear import - - - - GOC:TermGenie - single organism nuclear import - - - - - A nuclear import which involves only one organism. - GOC:TermGenie - GOC:jl - GO_REF:0000089 - - - - - - - - - - negative regulation of RNA biosynthetic process - - - - - - - - - - - - - - - - - - - - - - 2014-02-05T16:32:01Z - Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process. - GO:1902679 - biological_process - down regulation of RNA anabolism - down regulation of RNA biosynthesis - down regulation of RNA biosynthetic process - down regulation of RNA formation - down regulation of RNA synthesis - down-regulation of RNA anabolism - down-regulation of RNA biosynthesis - down-regulation of RNA biosynthetic process - down-regulation of RNA formation - down-regulation of RNA synthesis - downregulation of RNA anabolism - downregulation of RNA biosynthesis - downregulation of RNA biosynthetic process - downregulation of RNA formation - downregulation of RNA synthesis - inhibition of RNA anabolism - inhibition of RNA biosynthesis - inhibition of RNA biosynthetic process - inhibition of RNA formation - inhibition of RNA synthesis - jl - negative regulation of RNA anabolism - negative regulation of RNA biosynthesis - negative regulation of RNA formation - negative regulation of RNA synthesis - - - - GOC:TermGenie - inhibition of RNA synthesis - - - - - GOC:TermGenie - down regulation of RNA synthesis - - - - - GOC:TermGenie - down-regulation of RNA formation - - - - - GOC:TermGenie - negative regulation of RNA formation - - - - - GOC:TermGenie - down-regulation of RNA anabolism - - - - - GOC:TermGenie - down-regulation of RNA synthesis - - - - - GOC:TermGenie - downregulation of RNA anabolism - - - - - GOC:TermGenie - negative regulation of RNA synthesis - - - - - GOC:TermGenie - down regulation of RNA biosynthesis - - - - - GOC:TermGenie - downregulation of RNA synthesis - - - - - GOC:TermGenie - downregulation of RNA formation - - - - - GOC:TermGenie - down-regulation of RNA biosynthetic process - - - - - GOC:TermGenie - inhibition of RNA biosynthesis - - - - - GOC:TermGenie - negative regulation of RNA biosynthesis - - - - - GOC:TermGenie - down regulation of RNA biosynthetic process - - - - - GOC:TermGenie - inhibition of RNA formation - - - - - GOC:TermGenie - inhibition of RNA biosynthetic process - - - - - GOC:TermGenie - negative regulation of RNA anabolism - - - - - GOC:TermGenie - downregulation of RNA biosynthesis - - - - - GOC:TermGenie - downregulation of RNA biosynthetic process - - - - - GOC:TermGenie - down regulation of RNA anabolism - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process. - GO:jl - GOC:TermGenie - GO_REF:0000058 - - - - - GOC:TermGenie - down regulation of RNA formation - - - - - GOC:TermGenie - down-regulation of RNA biosynthesis - - - - - GOC:TermGenie - inhibition of RNA anabolism - - - - - - - - - - positive regulation of RNA biosynthetic process - - - - - - - - - - - - - - - - - - - - - - 2014-02-05T16:32:10Z - Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process. - GO:1902680 - activation of RNA anabolism - activation of RNA biosynthesis - activation of RNA biosynthetic process - activation of RNA formation - activation of RNA synthesis - biological_process - jl - positive regulation of RNA anabolism - positive regulation of RNA biosynthesis - positive regulation of RNA formation - positive regulation of RNA synthesis - up regulation of RNA anabolism - up regulation of RNA biosynthesis - up regulation of RNA biosynthetic process - up regulation of RNA formation - up regulation of RNA synthesis - up-regulation of RNA anabolism - up-regulation of RNA biosynthesis - up-regulation of RNA biosynthetic process - up-regulation of RNA formation - up-regulation of RNA synthesis - upregulation of RNA anabolism - upregulation of RNA biosynthesis - upregulation of RNA biosynthetic process - upregulation of RNA formation - upregulation of RNA synthesis - - - - GOC:TermGenie - activation of RNA formation - - - - - GOC:TermGenie - activation of RNA biosynthetic process - - - - - GOC:TermGenie - activation of RNA biosynthesis - - - - - GOC:TermGenie - up regulation of RNA synthesis - - - - - GOC:TermGenie - up-regulation of RNA biosynthesis - - - - - GOC:TermGenie - up-regulation of RNA anabolism - - - - - GOC:TermGenie - positive regulation of RNA formation - - - - - GOC:TermGenie - up regulation of RNA anabolism - - - - - GOC:TermGenie - activation of RNA anabolism - - - - - GOC:TermGenie - upregulation of RNA biosynthetic process - - - - - GOC:TermGenie - up regulation of RNA biosynthetic process - - - - - GOC:TermGenie - upregulation of RNA anabolism - - - - - GOC:TermGenie - upregulation of RNA synthesis - - - - - GOC:TermGenie - upregulation of RNA formation - - - - - GOC:TermGenie - activation of RNA synthesis - - - - - GOC:TermGenie - upregulation of RNA biosynthesis - - - - - GOC:TermGenie - positive regulation of RNA anabolism - - - - - GOC:TermGenie - up-regulation of RNA synthesis - - - - - Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process. - GO:jl - GOC:TermGenie - GO_REF:0000058 - - - - - GOC:TermGenie - up regulation of RNA formation - - - - - GOC:TermGenie - up-regulation of RNA formation - - - - - GOC:TermGenie - positive regulation of RNA synthesis - - - - - GOC:TermGenie - up-regulation of RNA biosynthetic process - - - - - GOC:TermGenie - up regulation of RNA biosynthesis - - - - - GOC:TermGenie - positive regulation of RNA biosynthesis - - - - - - - - - - mitotic cell cycle process - - - - - - - - - - - - - - - - - - - 2014-05-22T14:22:34Z - A process that is part of the mitotic cell cycle. - GO:1903047 - biological_process - jl - - - - A process that is part of the mitotic cell cycle. - GOC:TermGenie - GOC:mtg_cell_cycle - GO_REF:0000060 - - - - - - - - - - protein localization to actin cytoskeleton - - 2014-06-16T11:27:09Z - A process in which a protein is transported to, or maintained in, the location of an actin cytoskeleton. - GO:1903119 - biological_process - mah - protein localisation in actin cytoskeleton - protein localisation to actin cytoskeleton - protein localization in actin cytoskeleton - - - - GOC:TermGenie - protein localisation in actin cytoskeleton - - - - - GOC:TermGenie - protein localisation to actin cytoskeleton - - - - - A process in which a protein is transported to, or maintained in, the location of an actin cytoskeleton. - GOC:TermGenie - GO_REF:0000087 - PMID:24798735 - - - - - GOC:TermGenie - protein localization in actin cytoskeleton - - - - - - - - - - protein localization to actin filament bundle - - 2014-06-16T11:27:16Z - A process in which a protein is transported to, or maintained in, the location of an actin filament bundle. - GO:1903120 - biological_process - mah - protein localisation in actin filament bundle - protein localisation to actin filament bundle - protein localization in actin filament bundle - protein localization to actin cable - - - - GOC:mah - protein localization to actin cable - - - - - GOC:TermGenie - protein localization in actin filament bundle - - - - - A process in which a protein is transported to, or maintained in, the location of an actin filament bundle. - GOC:TermGenie - GO_REF:0000087 - PMID:24798735 - - - - - GOC:TermGenie - protein localisation to actin filament bundle - - - - - GOC:TermGenie - protein localisation in actin filament bundle - - - - - - - - - - protein localization to nuclear body - - 2014-09-01T13:57:11Z - A process in which a protein is transported to, or maintained in, a location within a nuclear body. - GO:1903405 - biological_process - mah - protein localisation in nuclear body - protein localisation to nuclear body - protein localization in nuclear body - - - - A process in which a protein is transported to, or maintained in, a location within a nuclear body. - GOC:TermGenie - GO_REF:0000087 - PMID:24713849 - - - - - GOC:TermGenie - protein localization in nuclear body - - - - - GOC:TermGenie - protein localisation in nuclear body - - - - - GOC:TermGenie - protein localisation to nuclear body - - - - - - - - - - regulation of nucleic acid-templated transcription - - - - - - - - - - - - - - - - - - - 2014-10-01T14:44:47Z - Any process that modulates the frequency, rate or extent of nucleic acid-templated transcription. - GO:1903506 - biological_process - pr - - - - Any process that modulates the frequency, rate or extent of nucleic acid-templated transcription. - GOC:TermGenie - GOC:pr - GOC:txnOH - GOC:vw - GO_REF:0000058 - - - - - - - - - - negative regulation of nucleic acid-templated transcription - - - - - - - - - - - - - - - - - - - - 2014-10-01T14:44:56Z - Any process that stops, prevents or reduces the frequency, rate or extent of nucleic acid-templated transcription. - GO:1903507 - biological_process - down regulation of nucleic acid-templated transcription - down-regulation of nucleic acid-templated transcription - downregulation of nucleic acid-templated transcription - inhibition of nucleic acid-templated transcription - pr - - - - GOC:TermGenie - downregulation of nucleic acid-templated transcription - - - - - GOC:TermGenie - down regulation of nucleic acid-templated transcription - - - - - GOC:TermGenie - down-regulation of nucleic acid-templated transcription - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of nucleic acid-templated transcription. - GOC:TermGenie - GOC:pr - GOC:txnOH - GOC:vw - GO_REF:0000058 - - - - - GOC:TermGenie - inhibition of nucleic acid-templated transcription - - - - - - - - - - positive regulation of nucleic acid-templated transcription - - - - - - - - - - - - - - - - - - - - 2014-10-01T14:45:04Z - Any process that activates or increases the frequency, rate or extent of nucleic acid-templated transcription. - GO:1903508 - activation of nucleic acid-templated transcription - biological_process - pr - up regulation of nucleic acid-templated transcription - up-regulation of nucleic acid-templated transcription - upregulation of nucleic acid-templated transcription - - - - GOC:TermGenie - up-regulation of nucleic acid-templated transcription - - - - - GOC:TermGenie - up regulation of nucleic acid-templated transcription - - - - - Any process that activates or increases the frequency, rate or extent of nucleic acid-templated transcription. - GOC:TermGenie - GOC:pr - GOC:txnOH - GOC:vw - GO_REF:0000058 - - - - - GOC:TermGenie - activation of nucleic acid-templated transcription - - - - - GOC:TermGenie - upregulation of nucleic acid-templated transcription - - - - - - - - - - regulation of protein targeting - - - - - - - - - - - - - - - - - - - 2014-10-08T14:49:03Z - Any process that modulates the frequency, rate or extent of protein targeting. - GO:1903533 - al - biological_process - regulation of nascent polypeptide association - regulation of protein sorting along secretory pathway - - - - GOC:TermGenie - regulation of nascent polypeptide association - - - - - Any process that modulates the frequency, rate or extent of protein targeting. - GOC:TermGenie - GO_REF:0000058 - - - - - GOC:TermGenie - regulation of protein sorting along secretory pathway - - - - - - - - - - regulation of cytoplasmic transport - - - - - - - - - - - - - - - - - - - 2014-11-24T13:38:17Z - Any process that modulates the frequency, rate or extent of cytoplasmic transport. - GO:1903649 - biological_process - jl - regulation of cytoplasmic streaming - - - - GOC:TermGenie - regulation of cytoplasmic streaming - - - - - Any process that modulates the frequency, rate or extent of cytoplasmic transport. - GOC:TermGenie - GO_REF:0000058 - PMID:25049409 - - - - - - - - - - negative regulation of cytoplasmic transport - - - - - - - - - - - - - - - - - - - - 2014-11-24T13:38:26Z - Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic transport. - GO:1903650 - biological_process - down regulation of cytoplasmic streaming - down regulation of cytoplasmic transport - down-regulation of cytoplasmic streaming - down-regulation of cytoplasmic transport - downregulation of cytoplasmic streaming - downregulation of cytoplasmic transport - inhibition of cytoplasmic streaming - inhibition of cytoplasmic transport - jl - negative regulation of cytoplasmic streaming - - - - GOC:TermGenie - downregulation of cytoplasmic transport - - - - - GOC:TermGenie - inhibition of cytoplasmic streaming - - - - - GOC:TermGenie - down-regulation of cytoplasmic transport - - - - - GOC:TermGenie - down regulation of cytoplasmic transport - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic transport. - GOC:TermGenie - GO_REF:0000058 - PMID:25049409 - - - - - GOC:TermGenie - inhibition of cytoplasmic transport - - - - - GOC:TermGenie - down regulation of cytoplasmic streaming - - - - - GOC:TermGenie - negative regulation of cytoplasmic streaming - - - - - GOC:TermGenie - downregulation of cytoplasmic streaming - - - - - GOC:TermGenie - down-regulation of cytoplasmic streaming - - - - - - - - - - positive regulation of cytoplasmic transport - - - - - - - - - - - - - - - - - - - - 2014-11-24T13:38:34Z - Any process that activates or increases the frequency, rate or extent of cytoplasmic transport. - GO:1903651 - activation of cytoplasmic streaming - activation of cytoplasmic transport - biological_process - jl - positive regulation of cytoplasmic streaming - up regulation of cytoplasmic streaming - up regulation of cytoplasmic transport - up-regulation of cytoplasmic streaming - up-regulation of cytoplasmic transport - upregulation of cytoplasmic streaming - upregulation of cytoplasmic transport - - - - GOC:TermGenie - up-regulation of cytoplasmic streaming - - - - - GOC:TermGenie - activation of cytoplasmic streaming - - - - - GOC:TermGenie - positive regulation of cytoplasmic streaming - - - - - GOC:TermGenie - upregulation of cytoplasmic streaming - - - - - GOC:TermGenie - up regulation of cytoplasmic streaming - - - - - GOC:TermGenie - up-regulation of cytoplasmic transport - - - - - GOC:TermGenie - up regulation of cytoplasmic transport - - - - - GOC:TermGenie - activation of cytoplasmic transport - - - - - GOC:TermGenie - upregulation of cytoplasmic transport - - - - - Any process that activates or increases the frequency, rate or extent of cytoplasmic transport. - GOC:TermGenie - GO_REF:0000058 - PMID:25049409 - - - - - - - - - - protein localization to vacuolar membrane - - - 2015-01-07T13:15:54Z - A process in which a protein is transported to, or maintained in, a location within a vacuolar membrane. - GO:1903778 - biological_process - mah - protein localisation in vacuolar membrane - protein localisation to vacuolar membrane - protein localization in vacuolar membrane - - - - GOC:TermGenie - protein localization in vacuolar membrane - - - - - A process in which a protein is transported to, or maintained in, a location within a vacuolar membrane. - GOC:TermGenie - GO_REF:0000087 - PMID:25378562 - - - - - GOC:TermGenie - protein localisation to vacuolar membrane - - - - - GOC:TermGenie - protein localisation in vacuolar membrane - - - - - - - - - - regulation of cellular protein localization - - - - - - - - - - - - - - - - - - - - 2015-01-20T14:32:14Z - Any process that modulates the frequency, rate or extent of cellular protein localization. - GO:1903827 - biological_process - jl - regulation of cellular protein localisation - regulation of channel localizer activity - - - - GOC:TermGenie - regulation of cellular protein localisation - - - - - GOC:TermGenie - regulation of channel localizer activity - - - - - Any process that modulates the frequency, rate or extent of cellular protein localization. - GOC:TermGenie - GOC:vw - GO_REF:0000058 - - - - - - - - - - negative regulation of cellular protein localization - - - - - - - - - - - - - - - - - - - - 2015-01-20T14:32:24Z - Any process that stops, prevents or reduces the frequency, rate or extent of cellular protein localization. - GO:1903828 - biological_process - down regulation of cellular protein localisation - down regulation of cellular protein localization - down regulation of channel localizer activity - down-regulation of cellular protein localisation - down-regulation of cellular protein localization - down-regulation of channel localizer activity - downregulation of cellular protein localisation - downregulation of cellular protein localization - downregulation of channel localizer activity - inhibition of cellular protein localisation - inhibition of cellular protein localization - inhibition of channel localizer activity - jl - negative regulation of cellular protein localisation - negative regulation of channel localizer activity - - - - GOC:TermGenie - negative regulation of cellular protein localisation - - - - - GOC:TermGenie - inhibition of channel localizer activity - - - - - GOC:TermGenie - down regulation of channel localizer activity - - - - - GOC:TermGenie - down-regulation of cellular protein localisation - - - - - GOC:TermGenie - down-regulation of cellular protein localization - - - - - GOC:TermGenie - downregulation of channel localizer activity - - - - - GOC:TermGenie - inhibition of cellular protein localisation - - - - - GOC:TermGenie - down-regulation of channel localizer activity - - - - - GOC:TermGenie - downregulation of cellular protein localization - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of cellular protein localization. - GOC:TermGenie - GOC:vw - GO_REF:0000058 - - - - - GOC:TermGenie - down regulation of cellular protein localization - - - - - GOC:TermGenie - down regulation of cellular protein localisation - - - - - GOC:TermGenie - negative regulation of channel localizer activity - - - - - GOC:TermGenie - downregulation of cellular protein localisation - - - - - GOC:TermGenie - inhibition of cellular protein localization - - - - - - - - - - positive regulation of cellular protein localization - - - - - - - - - - - - - - - - - - - - 2015-01-20T14:32:33Z - Any process that activates or increases the frequency, rate or extent of cellular protein localization. - GO:1903829 - activation of cellular protein localisation - activation of cellular protein localization - activation of channel localizer activity - biological_process - jl - positive regulation of cellular protein localisation - positive regulation of channel localizer activity - up regulation of cellular protein localisation - up regulation of cellular protein localization - up regulation of channel localizer activity - up-regulation of cellular protein localisation - up-regulation of cellular protein localization - up-regulation of channel localizer activity - upregulation of cellular protein localisation - upregulation of cellular protein localization - upregulation of channel localizer activity - - - - GOC:TermGenie - up-regulation of cellular protein localization - - - - - GOC:TermGenie - upregulation of channel localizer activity - - - - - GOC:TermGenie - upregulation of cellular protein localization - - - - - Any process that activates or increases the frequency, rate or extent of cellular protein localization. - GOC:TermGenie - GOC:vw - GO_REF:0000058 - - - - - GOC:TermGenie - up regulation of channel localizer activity - - - - - GOC:TermGenie - up-regulation of channel localizer activity - - - - - GOC:TermGenie - up regulation of cellular protein localization - - - - - GOC:TermGenie - activation of cellular protein localization - - - - - GOC:TermGenie - activation of cellular protein localisation - - - - - GOC:TermGenie - up-regulation of cellular protein localisation - - - - - GOC:TermGenie - activation of channel localizer activity - - - - - GOC:TermGenie - positive regulation of channel localizer activity - - - - - GOC:TermGenie - upregulation of cellular protein localisation - - - - - GOC:TermGenie - positive regulation of cellular protein localisation - - - - - GOC:TermGenie - up regulation of cellular protein localisation - - - - - - - - - - protein localization to nuclear periphery - - 2013-07-09T13:35:49Z - A process in which a protein is transported to, or maintained in, a location within the nuclear periphery. - GO:1990139 - biological_process - mah - - - - A process in which a protein is transported to, or maintained in, a location within the nuclear periphery. - GOC:mah - PMID:23703609 - - - - - - - - - - protein localization to nucleoplasm - - 2013-08-23T15:01:16Z - A process in which a protein is transported to, or maintained in, a location within the nucleoplasm. - GO:1990173 - biological_process - mah - protein localisation to nucleoplasm - - - - GOC:mah - protein localisation to nucleoplasm - - - - - A process in which a protein is transported to, or maintained in, a location within the nucleoplasm. - GOC:mah - PMID:22918952 - - - - - - - - - - regulation of cellular macromolecule biosynthetic process - - - - - - - - - - - - - - - - - - - - 2010-09-15T08:55:45Z - Any process that modulates the frequency, rate or extent of cellular macromolecule biosynthetic process. - GO:2000112 - biological_process - regulation of cellular biopolymer biosynthetic process - regulation of cellular macromolecule anabolism - regulation of cellular macromolecule biosynthesis - regulation of cellular macromolecule formation - regulation of cellular macromolecule synthesis - tanyaberardini - - - - GOC:obol - regulation of cellular macromolecule formation - - - - - Any process that modulates the frequency, rate or extent of cellular macromolecule biosynthetic process. - GOC:obol - - - - - GOC:obol - regulation of cellular macromolecule anabolism - - - - - GOC:obol - regulation of cellular biopolymer biosynthetic process - - - - - GOC:obol - regulation of cellular macromolecule biosynthesis - - - - - GOC:obol - regulation of cellular macromolecule synthesis - - - - - - - - - - negative regulation of cellular macromolecule biosynthetic process - - - - - - - - - - - - - - - - - - - - - 2010-09-15T08:55:48Z - Any process that stops, prevents, or reduces the frequency, rate or extent of cellular macromolecule biosynthetic process. - GO:2000113 - biological_process - negative regulation of cellular biopolymer biosynthetic process - negative regulation of cellular macromolecule anabolism - negative regulation of cellular macromolecule biosynthesis - negative regulation of cellular macromolecule formation - negative regulation of cellular macromolecule synthesis - tanyaberardini - - - - GOC:obol - negative regulation of cellular macromolecule synthesis - - - - - GOC:obol - negative regulation of cellular macromolecule biosynthesis - - - - - GOC:obol - negative regulation of cellular biopolymer biosynthetic process - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of cellular macromolecule biosynthetic process. - GOC:obol - - - - - GOC:obol - negative regulation of cellular macromolecule anabolism - - - - - GOC:obol - negative regulation of cellular macromolecule formation - - - - - - - - - - regulation of RNA biosynthetic process - - - - - - - - - - - - - - - - - - - - - 2011-10-17T11:36:25Z - Any process that modulates the frequency, rate or extent of RNA biosynthetic process. - GO:2001141 - biological_process - dph - regulation of RNA anabolism - regulation of RNA biosynthesis - regulation of RNA formation - regulation of RNA synthesis - - - - GOC:obol - regulation of RNA synthesis - - - - - Any process that modulates the frequency, rate or extent of RNA biosynthetic process. - GOC:dph - - - - - GOC:obol - regulation of RNA formation - - - - - GOC:obol - regulation of RNA biosynthesis - - - - - GOC:obol - regulation of RNA anabolism - - - - - - - - - - quality - A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities. - PATO:0000001 - PATO:0000072 - quality - trait - - - - A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities. - PATOC:GVG - - - - - - - - - - speed - - A physical quality inhering in a bearer by virtue of the bearer's scalar absolute value of the rate of change of the bearer's position. - PATO:0000008 - quality - velocity - - - - - - A physical quality inhering in a bearer by virtue of the bearer's scalar absolute value of the rate of change of the bearer's position. - Wikipedia:http://en.wikipedia.org/wiki/Velocity - - - - - - - - - - color brightness - - A scalar optical property that is the intensity, value or amount of perceived light. - Color brightness refers to the intensity, lightness or value of the light present. Think of this as a dimmer switch. - PATO:0000016 - color intensity - color lightness - color value - quality - - - - - A scalar optical property that is the intensity, value or amount of perceived light. - PATOC:MAH - - - - - - - - - - concentration of - - A quality inhering in a substance by virtue of the amount of the bearer's there is mixed with another substance. - PATO:0000033 - concentration - quality - - - - - - - A quality inhering in a substance by virtue of the amount of the bearer's there is mixed with another substance. - Wikipedia:http://en.wikipedia.org/wiki/concentration - - - - - - - - - - frequency - - A physical quality which inheres in a bearer by virtue of the number of the bearer's repetitive actions in a particular time. - PATO:0000044 - quality - - - - - - A physical quality which inheres in a bearer by virtue of the number of the bearer's repetitive actions in a particular time. - Wikipedia:http://en.wikipedia.org/wiki/frequency - - - - - - - - - - intensity - - A quality inhering in a bearer by virtue of the bearer's possessing or displaying a distinctive feature in type or degree or effect or force. - PATO:0000049 - quality - - - - - A quality inhering in a bearer by virtue of the bearer's possessing or displaying a distinctive feature in type or degree or effect or force. - PATOC:GVG - - - - - - - - - - morphology - - A quality of a single physical entity inhering in the bearer by virtue of the bearer's size or shape or structure. - PATO:0000051 - quality - - - - - A quality of a single physical entity inhering in the bearer by virtue of the bearer's size or shape or structure. - PATOC:GVG - - - - - - - - - - shape - - A morphological quality inhering in a bearer by virtue of the bearer's ratios of distances between its features (points, edges, surfaces and also holes etc). - PATO:0000052 - PATO:0001647 - Shapes are invariant on size transformations. Shapes can be subdivided into 2D and 3D shapes, We can also make a distinction between shapes of complete self-connected objects, and shapes of parts of objects. - quality - relational shape quality - - - - - A morphological quality inhering in a bearer by virtue of the bearer's ratios of distances between its features (points, edges, surfaces and also holes etc). - PATOC:GVG - - - - - - - - - - occurrence quality - - A quality of a single process inhering in a bearer by virtue of the bearer's occurrence. - PATO:0000057 - PATO:0000156 - PATO:0000158 - incidence - quality - temporal - - - - - A quality of a single process inhering in a bearer by virtue of the bearer's occurrence. - PATOC:GVG - - - - - - - - - - spatial pattern - - A spatial quality inhering in a bearer by virtue of the bearer's exhibiting repetition of placement of its parts. - PATO:0000060 - PATO:0000132 - PATO:0001565 - distribution - pattern - quality - - - - - A spatial quality inhering in a bearer by virtue of the bearer's exhibiting repetition of placement of its parts. - PATOC:GVG - - - - - - - - - - qualitative - - PATO:0000068 - TODO: define this or obsolete it and move children somewhere else. - quality - - - - - - - - - deviation(from_normal) - - A quality inhering in a bearer by virtue of the whether the bearer differs from normal or average. - PATO:0000069 - quality - - - - - A quality inhering in a bearer by virtue of the whether the bearer differs from normal or average. - PATOC:GVG - - - - - - - - - - size - - A morphology quality inhering in a bearer by virtue of the bearer's physical magnitude. - PATO:0000117 - quality - - - - - - A morphology quality inhering in a bearer by virtue of the bearer's physical magnitude. - WordNet:WordNet - - - - - - - - - - length - - A 1-D extent quality which is equal to the distance between two points. - PATO:0000122 - quality - - - - - - - A 1-D extent quality which is equal to the distance between two points. - PATOC:GVG - - - - - - - - - - mass - - A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter. - PATO:0000125 - quality - - - - - - - A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter. - PATOC:GVG - - - - - - - - - - position - - A spatial quality inhering in a bearer by virtue of the bearer's spatial location relative to other objects in the vicinity. - PATO:0000140 - PATO:0001032 - PATO:0001631 - location - placement - quality - relational spatial quality - - - - - A spatial quality inhering in a bearer by virtue of the bearer's spatial location relative to other objects in the vicinity. - PATOC:GVG - - - - - - - - - - structure - - A morphology quality inhering in a bearer by virtue of the bearer's relative position, shape, arrangements and connectivity of an organism's various parts; the pattern underlying its form. - PATO:0000141 - PATO:0001452 - quality - relational structural quality - - - - - A morphology quality inhering in a bearer by virtue of the bearer's relative position, shape, arrangements and connectivity of an organism's various parts; the pattern underlying its form. - PATOC:GVG - - - - - - - - - - rate - - A quality of a single process inhering in a bearer by virtue of the bearer's occurrence per unit time. - PATO:0000161 - quality - - - - - - A quality of a single process inhering in a bearer by virtue of the bearer's occurrence per unit time. - PATOC:melissa - - - - - - - - - - viability - - An organismal quality inhering in a bearer or a population by virtue of the bearer's disposition to survive and develop normally or the number of surviving individuals in a given population. - PATO:0000169 - quality - - - - - - An organismal quality inhering in a bearer or a population by virtue of the bearer's disposition to survive and develop normally or the number of surviving individuals in a given population. - PATOC:GVG - - - - - - - - - - arrested - - - - - - - - - A quality of a process which ends earlier than the natural end time or reference process. - PATO:0000297 - PATO:0001508 - TODO: the definition is incorrect. See absent. - abolished - incomplete - quality - - - - - A quality of a process which ends earlier than the natural end time or reference process. - PATOC:LC - - - - - - - - - - increased speed - - - - - - - - - - - - - - - - - - - - A speed which is relatively high. - PATO:0000303 - fast speed - high speed - quality - - - - - A speed which is relatively high. - PATOC:GVG - - - - - - - - - - decreased speed - - - - - - - - - - - - - - - - - - - - A speed which is relatively low. - PATO:0000304 - quality - slow - slow speed - - - - - A speed which is relatively low. - PATOC:GVG - - - - - - - - - - irregular spatial pattern - - A spatial pattern inhering in a bearer by virtue of the bearer's magnitude of or the relationships between its repeated parts lack consistency. - PATO:0000330 - quality - - - - - - - A spatial pattern inhering in a bearer by virtue of the bearer's magnitude of or the relationships between its repeated parts lack consistency. - PATOC:GVG - - - - - - - - - - increased frequency - - - - - - - - - - - - - - - - - - - - A frequency which is relatively high. - PATO:0000380 - frequent - high frequency - quality - - - - - - A frequency which is relatively high. - PATOC:GVG - - - - - - - - - - decreased frequency - - - - - - - - - - - - - - - - - - - - A frequency which is relatively low. - PATO:0000381 - infrequent - low frequency - quality - - - - - - A frequency which is relatively low. - PATOC:GVG - - - - - - - - - - mild - - An intensity which is less than moderate in type or degree or effect or force. - PATO:0000394 - quality - - - - - - An intensity which is less than moderate in type or degree or effect or force. - PATOC:GVG - - - - - - - - - - severe - - An intensity which is extremely bad or unpleasant in type or degree or effect or force. - PATO:0000396 - quality - - - - - - An intensity which is extremely bad or unpleasant in type or degree or effect or force. - WordNet:WordNet - - - - - - - - - - curved - - A curvature quality inhering in a bearer by virtue of the bearer's having or being marked by a curve or smoothly rounded bend. - PATO:0000406 - bowing - curled - quality - - - - - - A curvature quality inhering in a bearer by virtue of the bearer's having or being marked by a curve or smoothly rounded bend. - WordNet:WordNet - - - - - - - - - - circular - - A shape quality inhering in a bearer by virtue of the bearer's being such that every part of the surface or the circumference is equidistant from the center. - PATO:0000411 - quality - round - rounded - - - - - - - A shape quality inhering in a bearer by virtue of the bearer's being such that every part of the surface or the circumference is equidistant from the center. - thefreedictionary.com:thefreedictionary.com - - - - - - - - - - regular spatial pattern - - A pattern quality inhering in a bearer by virtue of the bearer's having a repeatable or predictable placement. - PATO:0000440 - quality - - - - - - - A pattern quality inhering in a bearer by virtue of the bearer's having a repeatable or predictable placement. - PATOC:GVG - - - - - - - - - - abnormal - - A quality inhering in a bearer by virtue of the bearer's deviation from normal or average. - PATO:0000460 - aberrant - atypia - atypical - defective - quality - - - - - - - A quality inhering in a bearer by virtue of the bearer's deviation from normal or average. - PATOC:GVG - - - - - - - - - - normal - - A quality inhering in a bearer by virtue of the bearer's exhibiting no deviation from normal or average. - PATO:0000461 - average - quality - - - - - - - A quality inhering in a bearer by virtue of the bearer's exhibiting no deviation from normal or average. - PATOC:GVG - - - - - - - - - - increased duration - - - - - - - - - - - - - - - - - - - - A duration quality of a process which is relatively high. - PATO:0000498 - PATO:0000715 - chronic - high time - increased period - increased time - prolonged period - quality - slow time - - - - - A duration quality of a process which is relatively high. - PATOC:GVG - - - - - - - - - - decreased duration - - - - - - - - - - - - - - - - - - - - A duration quality of a process which is relatively low. - PATO:0000499 - PATO:0000716 - decreased period - decreased time - fast time - low period - quality - shortened period - - - - - A duration quality of a process which is relatively low. - PATOC:GVG - - - - - - - - - - delayed - - A quality of a process which starts later than the natural start time or the reference process. - PATO:0000502 - late - quality - - - - - A quality of a process which starts later than the natural start time or the reference process. - PATOC:LC - - - - - - - - - - increased length - - - - - - - - - - - - - - - - - - - - A length quality which is relatively large. - PATO:0000573 - long - quality - - - - - A length quality which is relatively large. - PATOC:GVG - - - - - - - - - - decreased length - - - - - - - - - - - - - - - - - - - - A length quality which is relatively small. - PATO:0000574 - quality - short - shortened - stubby - - - - - A length quality which is relatively small. - PATOC:GVG - - - - - - - - - - increased size - - - - - - - - - - - - - - - - - - - - A size quality which is relatively high. - PATO:0000586 - PATO:0001202 - big - enlarged - expanded - great - large - quality - - - - - A size quality which is relatively high. - PATOC:GVG - - - - - - - - - - decreased size - - - - - - - - - - - - - - - - - - - - A size quality which is relatively low. - PATO:0000587 - hypoplasia - quality - small - tiny - underdeveloped - - - - - A size quality which is relatively low. - PATOC:GVG - - - - - - - - - - increased thickness - - - - - - - - - - - - - - - - - - - - A thickness which is relatively high. - PATO:0000591 - high thickness - quality - stout - thick - thickened - - - - - - A thickness which is relatively high. - PATOC:GVG - - - - - - - - - - decreased thickness - - - - - - - - - - - - - - - - - - - - A thickness which is relatively low. - PATO:0000592 - low thickness - quality - slender - thin - - - - - - A thickness which is relatively low. - PATOC:GVG - - - - - - - - - - increased volume - - - - - - - - - - - - - - - - - - - - A volume which is relatively high. - PATO:0000595 - high volume - large volume - quality - - - - - - A volume which is relatively high. - PATOC:GVG - - - - - - - - - - decreased volume - - - - - - - - - - - - - - - - - - - - A volume which is relatively low. - PATO:0000596 - low volume - quality - small volume - - - - - - A volume which is relatively low. - PATOC:GVG - - - - - - - - - - decreased width - - - - - - - - - - - - - - - - - - - - A width which is relatively small. - PATO:0000599 - narrow - quality - - - - - A width which is relatively small. - PATOC:GVG - - - - - - - - - - increased width - - - - - - - - - - - - - - - - - - - - A width which is relatively large. - PATO:0000600 - broad - quality - wide - wide/broad - - - - - A width which is relatively large. - PATOC:GVG - - - - - - - - - - asymmetrical - - A symmetry quality inhering in a bearer by virtue of the bearer's lacking symmetry. - PATO:0000616 - asymmetric - asymmetry - quality - - - - - - - A symmetry quality inhering in a bearer by virtue of the bearer's lacking symmetry. - PATOC:GVG - - - - - - - - - - bilateral - - A positional quality inhering in a bearer by virtue of the bearer's having two sides; two-sided. - PATO:0000618 - quality - - - - - - A positional quality inhering in a bearer by virtue of the bearer's having two sides; two-sided. - thefreedictionary.com:thefreedictionary.com - - - - - - - - - - apoptotic - - A structural quality inhering in a bearer by virtue of the bearer's consisting of blebbing of the nucleus and DNA fragmentation due to the cell undergoing a specific form of programmed cell death termed apoptosis. - GO:0006915 - PATO:0000638 - quality - - - - - A structural quality inhering in a bearer by virtue of the bearer's consisting of blebbing of the nucleus and DNA fragmentation due to the cell undergoing a specific form of programmed cell death termed apoptosis. - PATOC:GVG - - - - - - - - - - high brightness - - A color brightness which is relatively high. - PATO:0000665 - light - quality - - - - - A color brightness which is relatively high. - PATOC:MAH - - - - - - - - - - continuous - - A quality of a single process inhering in a bearer by virtue of the bearer's being uninterrupted in time, sequence, substance, or extent. - PATO:0000429 - PATO:0000689 - quality - uninterrupted - - - - - A quality of a single process inhering in a bearer by virtue of the bearer's being uninterrupted in time, sequence, substance, or extent. - thefreedictionary.com:thefreedictionary.com - - - - - - - - - - lethal (sensu genetics) - - A viability quality inhering in a population by virtue of the bearer's long term survival inability. - PATO:0000718 - quality - - - - - - A viability quality inhering in a population by virtue of the bearer's long term survival inability. - PATOC:GVG - - - - - - - - - - viable - - A viability quality inhering in a bearer or a population by virtue of the bearer's ability to survive or the long term survival ability of a given population. - PATO:0000719 - quality - - - - - - A viability quality inhering in a bearer or a population by virtue of the bearer's ability to survive or the long term survival ability of a given population. - PATOC:GVG - - - - - - - - - - decreased rate - - - - - - - - - - - - - - - - - - - - A rate which is relatively low. - PATO:0000911 - quality - slow rate - - - - - - A rate which is relatively low. - PATO:GVG - - - - - - - - - - increased rate - - - - - - - - - - - - - - - - - - - - A rate which is relatively high. - PATO:0000912 - fast rate - high rate - quality - - - - - - A rate which is relatively high. - PATO:GVG - - - - - - - - - - thickness - - A 1-D extent quality which is equal to the dimension through an object as opposed to its length or width. - PATO:0000915 - quality - - - - - - A 1-D extent quality which is equal to the dimension through an object as opposed to its length or width. - WordNet:WordNet - - - - - - - - - - volume - - A 3-D extent quality inhering in a bearer by virtue of the bearer's amount of 3-dimensional space it occupies. - PATO:0000918 - quality - - - - - - - A 3-D extent quality inhering in a bearer by virtue of the bearer's amount of 3-dimensional space it occupies. - PATOC:GVG - - - - - - - - - - width - - A 1-D extent quality which is equal to the distance from one side of an object to another side which is opposite. - PATO:0000921 - This term is for curator easiness - we might consider obsoleting this but we have to consider how curators are going to represent them if we do. - breadth - quality - - - - - - A 1-D extent quality which is equal to the distance from one side of an object to another side which is opposite. - PATOC:GVG - - - - - - - - - - disorganized - - A structural quality inhering in a bearer by virtue of the bearer's lacking organisation. - PATO:0000937 - quality - - - - - - A structural quality inhering in a bearer by virtue of the bearer's lacking organisation. - PATOC:GVG - - - - - - - - - - sharpness - - A shape quality inhering in a bearer by virtue of the bearer's having a sharp or tapered end or point. - PATO:0000944 - apiculate - quality - - - - - - A shape quality inhering in a bearer by virtue of the bearer's having a sharp or tapered end or point. - PATOC:GVG - - - - - - - - - - elliptic - - A spheroid quality inhering in a bearer by virtue of the bearer's being oval with two axes of symmetry, as produced by a conical section. - PATO:0000947 - ellipse-shaped - ellipsoid - elliptical - oval - ovoid - quality - - - - - - - A spheroid quality inhering in a bearer by virtue of the bearer's being oval with two axes of symmetry, as produced by a conical section. - PATOC:GVG - - - - - - - - - - symmetry - - A pattern quality of inhering in a bearer by virtue of the correspondence in size, shape, and relative position of the bearer's parts on opposite sides of a dividing line or median plane or about a center or axis. - PATO:0000965 - quality - - - - - A pattern quality of inhering in a bearer by virtue of the correspondence in size, shape, and relative position of the bearer's parts on opposite sides of a dividing line or median plane or about a center or axis. - PATOC:GVG - - - - - - - - - - physical quality - - A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities. - PATO:0001018 - PATO:0002079 - Wikipedia:Physical_property - quality - relational physical quality - - - - - A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities. - PATOC:GVG - - - - - - - - - - elongated - - A quality inhering in a bearer by virtue of the bearer's length being notably higher than its width. - PATO:0001154 - quality - - - - - A quality inhering in a bearer by virtue of the bearer's length being notably higher than its width. - WordNet:WordNet - - - - - - - - - - concentrated - - A concentration quality inhering in a bearer by virtue of the bearer's exhibiting concentration. - PATO:0001159 - quality - - - - - - A concentration quality inhering in a bearer by virtue of the bearer's exhibiting concentration. - PATOC:GVG - - - - - - - - - - increased concentration - - - - - - - - - - - - - - - - - - - - A concentration which is higher relative to the normal or average. - PATO:0001162 - high concentration - quality - - - - - - A concentration which is higher relative to the normal or average. - PATOC:GVG - - - - - - - - - - decreased concentration - - - - - - - - - - - - - - - - - - - - A concentration which is lower relative to the normal or average. - PATO:0001163 - low concentration - quality - - - - - - A concentration which is lower relative to the normal or average. - PATOC:GVG - - - - - - - - - - process quality - - A quality which inheres in an process. - PATO:0001236 - PATO:0001239 - PATO:0001240 - See comments of relational quality of a physical entity. - quality - quality of a process - quality of occurrent - quality of process - relational quality of occurrent - - - - A quality which inheres in an process. - PATOC:GVG - - - - - - - - - - physical object quality - - A quality which inheres in a continuant. - PATO:0001237 - PATO:0001238 - PATO:0001241 - Relational qualities are qualities that hold between multiple entities. Normal (monadic) qualities such as the shape of a eyeball exist purely as a quality of that eyeball. A relational quality such as sensitivity to light is a quality of that eyeball (and connecting nervous system) as it relates to incoming light waves/particles. - monadic quality of a continuant - monadic quality of an object - monadic quality of continuant - multiply inhering quality of a physical entity - quality - quality of a continuant - quality of a single physical entity - quality of an object - quality of continuant - snap:Quality - - - - A quality which inheres in a continuant. - PATOC:GVG - - - - - - - - - - electromagnetic (EM) radiation quality - - A physical quality that inheres in an bearer by virtue of how that bearer interacts with electromagnetic radiation. - PATO:0001291 - quality - - - - - A physical quality that inheres in an bearer by virtue of how that bearer interacts with electromagnetic radiation. - Wikipedia:http://en.wikipedia.org/wiki/Electromagnetic_radiation - - - - - - - - - - optical quality - - An EM radiation quality in which the EM radiation is within the fiat range of the spectrum visible deemed to be light. - PATO:0001300 - quality - - - - - An EM radiation quality in which the EM radiation is within the fiat range of the spectrum visible deemed to be light. - PATOC:GVG - - - - - - - - - - variability - - A quality inhering in a bearer by virtue of the bearer's disposition to varying or changing. - PATO:0001303 - quality - variability of a physical quality - - - - - A quality inhering in a bearer by virtue of the bearer's disposition to varying or changing. - Dictionary:http://dictionary.reference.com/ - - - - - - - - - - duration quality of a process - - A process quality inhering in a bearer by virtue of the bearer's magnitude of the temporal extent between the starting and ending point. - PATO:0000081 - PATO:0001309 - period - quality - time - - - - - A process quality inhering in a bearer by virtue of the bearer's magnitude of the temporal extent between the starting and ending point. - PATOC:mellybelly - - - - - - - - - - area - - A 2-D extent quality inhering in a bearer by virtue of the bearer's two dimensional extent. - PATO:0001323 - quality - - - - - - - A 2-D extent quality inhering in a bearer by virtue of the bearer's two dimensional extent. - Wikipedia:http://en.wikipedia.org/wiki/Area - - - - - - - - - - radial symmetry - - A symmetry quality inhering in a bearer by virtue of the bearer's having equal proportion around a central point or axis. - PATO:0001325 - quality - - - - - - A symmetry quality inhering in a bearer by virtue of the bearer's having equal proportion around a central point or axis. - PATOC:GVG - - - - - - - - - - spiny - - A surface feature shape quality inhering in a bearer by virtue of the bearer's having spines, thorns or similar thin projections on its surface. - PATO:0001365 - quality - - - - - - A surface feature shape quality inhering in a bearer by virtue of the bearer's having spines, thorns or similar thin projections on its surface. - PATOC:GVG - - - - - - - - - - ploidy - - A cellular quality inhering in a bearer by virtue of the bearer's number of homologous sets of chromosomes in the nucleus or primary chromosome-containing compartment of the cell, each set essentially coding for all the biological traits of the organism. - PATO:0001374 - quality - - - - - A cellular quality inhering in a bearer by virtue of the bearer's number of homologous sets of chromosomes in the nucleus or primary chromosome-containing compartment of the cell, each set essentially coding for all the biological traits of the organism. - Wikipedia:http://en.wikipedia.org/wiki/Ploidy - - - - - - - - - - polyploid - - A ploidy quality inhering in a bearer by virtue of the bearer's containing more than two homologous sets of chromosomes. - PATO:0001377 - quality - - - - - - A ploidy quality inhering in a bearer by virtue of the bearer's containing more than two homologous sets of chromosomes. - Wikipedia:http://en.wikipedia.org/wiki/Polyploid - - - - - - - - - - euploid - - A ploidy quality inhering in a bearer by virtue of the bearer's containing an integral multiple of the monoploid number, possibly excluding the sex-determining chromosomes. - PATO:0001393 - quality - - - - - - A ploidy quality inhering in a bearer by virtue of the bearer's containing an integral multiple of the monoploid number, possibly excluding the sex-determining chromosomes. - Wikipedia:http://en.wikipedia.org/wiki/Euploid - - - - - - - - - - cellular quality - - A monadic quality of continuant that exists at the cellular level of organisation. - PATO:0001396 - quality - - - - A monadic quality of continuant that exists at the cellular level of organisation. - PATOC:GVG - - - - - - - - - - nucleate quality - - A cellular quality inhering in a bearer by virtue of bearer's number of nuclei. - PATO:0001404 - quality - - - - - A cellular quality inhering in a bearer by virtue of bearer's number of nuclei. - PATOC:GVG - - - - - - - - - - binucleate - - A nucleate quality inhering in a bearer by virtue of the bearer's having two nuclei. - PATO:0001406 - quality - - - - - - - A nucleate quality inhering in a bearer by virtue of the bearer's having two nuclei. - Biology-online:Biology-online - - - - - - - - - - mononucleate - - A nucleate quality inhering in a bearer by virtue of the bearer's having one nucleus. - PATO:0001407 - quality - - - - - - - A nucleate quality inhering in a bearer by virtue of the bearer's having one nucleus. - Biology-online:Biology-online - - - - - - - - - - sharp - - A shape quality inhering in a bearer by virtue of the bearer's terminating in a point or edge. - PATO:0001419 - quality - - - - - - A shape quality inhering in a bearer by virtue of the bearer's terminating in a point or edge. - PATOC:GVG - - - - - - - - - - wholeness - - A structural quality inhering in a bearer by virtue of whether the bearer includes all its components. - PATO:0001442 - quality - - - - - A structural quality inhering in a bearer by virtue of whether the bearer includes all its components. - thefreedictionary.com:thefreedictionary.com - - - - - - - - - - broken - - A broken quality inhering in a bearer by virtue of the bearer's being broken open. - PATO:0001443 - PATO:0001444 - PATO:0001820 - burst - cracked - fractured - fragmented - hemorrhaged - quality - ruptured - split - torn - - - - - - A broken quality inhering in a bearer by virtue of the bearer's being broken open. - PATOC:GVG - - - - - - - - - - tapered - - A shape quality inhering in a bearer by virtue of the bearer's being gradually narrower or thinner toward one end. - PATO:0001500 - quality - taper - - - - - - A shape quality inhering in a bearer by virtue of the bearer's being gradually narrower or thinner toward one end. - WordNet:WordNet - - - - - - - - - - punctate - - A pattern inhering in a surface by virtue of the bearer's being marked by the presence of dots, punctures, points or pits. - PATO:0001512 - dotted - quality - spotted - stippled - - - - - - A pattern inhering in a surface by virtue of the bearer's being marked by the presence of dots, punctures, points or pits. - medical-dictionary:medical-dictionary - - - - - - - - - - has number of - - OBO_REL:has_part - PATO:0001555 - The number of parts of a particular type that the bearer entity has. This is a relational quality, and thus holds between two entities: the bearer of the quality, and the type of parts. - cardinality - extra or missing physical or functional parts - has or lacks parts of type - mereological quality - number - number of - quality - - - - - - PATOC:CJM - The number of parts of a particular type that the bearer entity has. This is a relational quality, and thus holds between two entities: the bearer of the quality, and the type of parts. - - - - - - - - - - lacking processual parts - - A quality of a process inhering in a bearer by virtue of the bearer's lacking a processual part as specified by the additional entity. - PATO:0001558 - quality - - - - - - A quality of a process inhering in a bearer by virtue of the bearer's lacking a processual part as specified by the additional entity. - PATOC:GVG - - - - - - - - - - decreased mass - - - - - - - - - - - - - - - - - - - - A mass which is lower than normal or average. - PATO:0000579 - PATO:0001562 - low mass - quality - small mass - - - - - A mass which is lower than normal or average. - PATO:GVG - - - - - - - - - - increased mass - - - - - - - - - - - - - - - - - - - - A mass which is higher than normal or average. - PATO:0000578 - PATO:0001563 - high mass - large mass - quality - - - - - A mass which is higher than normal or average. - PATO:GVG - - - - - - - - - - extra or missing processual parts - - A quality of a process inhering in a bearer by virtue of the bearer's processual parts. - PATO:0001564 - quality - - - - - A quality of a process inhering in a bearer by virtue of the bearer's processual parts. - PATOC:GVG - - - - - - - - - - curvature - - A surface shape quality inhering in a bearer by virtue of the bearer's exhibiting a degree of bending. - PATO:0001591 - quality - - - - - A surface shape quality inhering in a bearer by virtue of the bearer's exhibiting a degree of bending. - WordNet:WordNet - - - - - - - - - - deformed - - A morphological quality inhering in a bearer by virtue of the bearer's being distorted in form. - PATO:0001617 - disfigured - distorted - quality - - - - - A morphological quality inhering in a bearer by virtue of the bearer's being distorted in form. - thefreedictionary.com:thefreedictionary.com - - - - - - - - - - aggregated - - A spatial pattern inhering in a bearer by virtue of the bearer's being gathered or tending to gather into a mass or whole. - PATO:0001629 - clustered - quality - - - - - - A spatial pattern inhering in a bearer by virtue of the bearer's being gathered or tending to gather into a mass or whole. - WordNet:WordNet - - - - - - - - - - dispersed - - A positional quality inhering in a bearer by virtue of the bearer's being distributed or spread over a considerable extent. - PATO:0001630 - quality - - - - - - A positional quality inhering in a bearer by virtue of the bearer's being distributed or spread over a considerable extent. - WordNet:WordNet - - - - - - - - - - stubby - - A size quality inhering in a bearer by virtue of the bearer's having a short, stocky build. - PATO:0001643 - quality - - - - - A size quality inhering in a bearer by virtue of the bearer's having a short, stocky build. - thefreedictionary.com:thefreedictionary.com - - - - - - - - - - 1-D extent - - 1-D size - A size quality inhering in an bearer by virtue of the bearer's extension in one dimension. - PATO:0001708 - quality - - - - - A size quality inhering in an bearer by virtue of the bearer's extension in one dimension. - PATOC:GVG - - - - - - - - - - 2-D extent - - 2-D size - A size quality inhering in an bearer by virtue of the bearer's extension in two dimensions. - PATO:0001709 - quality - - - - - A size quality inhering in an bearer by virtue of the bearer's extension in two dimensions. - PATOC:GVG - - - - - - - - - - 3-D extent - - 3D size - A size quality inhering in an bearer by virtue of the bearer's extension in three dimensions. - PATO:0001710 - quality - - - - - A size quality inhering in an bearer by virtue of the bearer's extension in three dimensions. - PATOC:GVG - - - - - - - - - - radiation quality - - A quality that inheres in an bearer by virtue of how that bearer interacts with radiation. - PATO:0001739 - quality - - - - - A quality that inheres in an bearer by virtue of how that bearer interacts with radiation. - PATOC:GVG - - - - - - - - - - surrounding - - A spatial quality inhering in a bearer by virtue of the bearer's being extended on all sides of another entity simultaneously. - PATO:0001772 - encircling - quality - - - - - - A spatial quality inhering in a bearer by virtue of the bearer's being extended on all sides of another entity simultaneously. - thefreedictionary.com:thefreedictionary.com - - - - - - - - - - triangular - - A shape quality inhering in a bearer by virtue of the bearer's having three angles. - PATO:0001875 - deltoid - quality - triangle - triangle-shaped - - - - - - A shape quality inhering in a bearer by virtue of the bearer's having three angles. - wordreference:wordreference - - - - - - - - - - sigmoid - - A shape quality inhering in a bearer by virtue of the bearer's consisting of two curves, in opposite directions. S-shaped. - PATO:0001878 - S-shaped - quality - sigmoidal - - - - - - A shape quality inhering in a bearer by virtue of the bearer's consisting of two curves, in opposite directions. S-shaped. - PATOC:CJM - - - - - - - - - - arrow-shaped - - A shape quality inhering in a bearer by virtue of the bearer's forming two equal obtuse triangles with a short side in common. - Gradually enlarged at the base, like the head of an arrow. - PATO:0001881 - quality - sagittate - - - - - - A shape quality inhering in a bearer by virtue of the bearer's forming two equal obtuse triangles with a short side in common. - ISBN:0881923214 - RKC:RKC - - - - - - - - - - movement quality - - A physical quality inhering in a bearer by virtue of the bearer's participation in movement. - PATO:0001906 - quality - - - - - A physical quality inhering in a bearer by virtue of the bearer's participation in movement. - PATOC:GVG - - - - - - - - - - multinucleate - - A nucleate quality inhering in a bearer by virtue of the bearer's having more than one nucleus. - PATO:0001908 - quality - - - - - - A nucleate quality inhering in a bearer by virtue of the bearer's having more than one nucleus. - PATOC:GVG - - - - - - - - - - surface feature shape - - A surface shape quality inhering in a bearer by virtue of the bearer's shape of features present on its surface or outer shell. - PATO:0001925 - This quality either inheres directly in the surface, or in the entity that has the surface. For example, to say that a particular fly wing is curved is shorthand for saying the wing has a surface which is curved. - quality - - - - - A surface shape quality inhering in a bearer by virtue of the bearer's shape of features present on its surface or outer shell. - PATOC:CJM - - - - - - - - - - variability of shape - - - - - - - - A variability quality inhering in a bearer by virtue of whether the bearer exhibits shape variation or change. - PATO:0001929 - quality - - - - - A variability quality inhering in a bearer by virtue of whether the bearer exhibits shape variation or change. - PATOC:GVG - - - - - - - - - - variability of size - - - - - - - - A variability quality inhering in a bearer by virtue of whether the bearer exhibits size variation or change. - PATO:0001956 - quality - - - - - A variability quality inhering in a bearer by virtue of whether the bearer exhibits size variation or change. - PATOC:GVG - - - - - - - - - - increased variability of size - - - - - - - - - - - - - - - - - - - - A variability of size which is relatively high. - PATO:0001958 - high variability of size - quality - - - - - A variability of size which is relatively high. - PATOC:GVG - - - - - - - - - - lobed - - A shape quality inhering in a bearer by virtue of the bearer's being partly divided into a determinate number of regions. - PATO:0001979 - quality - - - - - - A shape quality inhering in a bearer by virtue of the bearer's being partly divided into a determinate number of regions. - ISBN:0881923214 - - - - - - - - - - organismal quality - - A quality that inheres in an entire organism or part of an organism. - PATO:0001995 - quality - - - - A quality that inheres in an entire organism or part of an organism. - PATOC:CJM - - - - - - - - - - lacks parts or has fewer parts of type - - PATO:0001999 - The bearer of this quality has_part < n of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e has fewer parts of type X at time t, then the number of instances x of X at t such that x part_of e is < n, where n is either the normal number for comparable entities, or n is stated explicitly. This case includes the limit case, where the bearer lacks all parts of the specified type. - loss of - quality - - - - - PATOC:CJM - The bearer of this quality has_part < n of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e has fewer parts of type X at time t, then the number of instances x of X at t such that x part_of e is < n, where n is either the normal number for comparable entities, or n is stated explicitly. This case includes the limit case, where the bearer lacks all parts of the specified type. - - - - - - - - - - lacks all parts of type - - A quality of physical entities inhering in a bearer by virtue of the bearer's lacking a physical part as specified by the additional entity. - Example: [E=organism Q=lacks_all_parts_of_type E2=Wing] - applies to an organism. A relational quality in which the bearer entity has no parts of the specified type. The bearer of this quality has_part = 0 of the indicated entity type, where a comparable organism usually has at least 1 part of the same type. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e lacks all parts of type X at time t, then there exists no instances x of X at t such that x part_of e that has no wings, where wings are normally present in that organism type. In OWL this is equivalent to a restriction on the OBO_REL:has_part relation with cardinality=0, i.e has_part 0 E2. - OBO_REL:lacks_part - PATO:0001557 - PATO:0002000 - lacks all physical parts of type - quality - - - - - A quality of physical entities inhering in a bearer by virtue of the bearer's lacking a physical part as specified by the additional entity. - PATOC:CJM - - - - - - - - - - has fewer parts of type - - - - - - - - - - - - - - - - - - - - Example: [E=hand Q=has_fewer_parts_of_type E2=digit] - applies to an organism that has no less fingers than is normal for organisms of that type. - PATO:0001569 - PATO:0002001 - The bearer of this quality has_part < n AND has_part > 0 of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e has fewer parts of type X at time t, then the number of instances x of X at t such that x part_of e is < n, where n is either the normal number for comparable entities, or n is stated explicitly. - decreased number of - has decreased number of - has fewer physical parts of type - quality - - - - - PATOC:CJM - The bearer of this quality has_part < n AND has_part > 0 of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e has fewer parts of type X at time t, then the number of instances x of X at t such that x part_of e is < n, where n is either the normal number for comparable entities, or n is stated explicitly. - - - - - - - - - - has extra parts of type - - - - - - - - - - - - - - - - - - - - In polydactyly, the bearer of the quality is the hand, and the entity type being counted is 'finger'. In EQ syntax, E=hand, Q=<this> E2=finger. - PATO:0001560 - PATO:0002002 - The bearer of this quality has_part > n of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part. - has extra parts of - has increased number of - having extra physical parts - having supernumerary physical parts - increased number of - quality - - - - - PATOC:CJM - The bearer of this quality has_part > n of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part. - - - - - - - - - - 2-D shape - - 2-D projection - A shape that inheres in a 2 dimensional entity, such as a cross section or projection of a 3 dimensional entity. - PATO:0002006 - cross-sectional - quality - - - - - A shape that inheres in a 2 dimensional entity, such as a cross section or projection of a 3 dimensional entity. - PATOC:CJM - - - - - - - - - - increased occurrence - - - - - - - - - - - - - - - - - - - - 2009-03-26T11:10:11Z - An occurrence which is relatively high. - George Gkoutos - PATO:0002051 - increased incidence - quality - - - - An occurrence which is relatively high. - PATOC:GVG - - - - - - - - - - decreased occurrence - - - - - - - - - - - - - - - - - - - - 2009-03-26T11:12:35Z - An occurrence which is relatively low. - George Gkoutos - PATO:0002052 - decreased incidence - quality - - - - An occurrence which is relatively low. - PATOC:GVG - - - - - - - - - - increased area - - - - - - - - - - - - - - - - - - - - 2009-03-30T04:11:43Z - An area which is relatively high. - George Gkoutos - PATO:0002057 - quality - - - - - An area which is relatively high. - PATOC:GVG - - - - - - - - - - decreased area - - - - - - - - - - - - - - - - - - - - 2009-03-30T04:12:11Z - An area which is relatively low. - George Gkoutos - PATO:0002058 - quality - - - - - An area which is relatively low. - PATOC:GVG - - - - - - - - - - physical quality of a process - - 2009-06-05T09:16:46Z - PATO:0002062 - george - quality - - - - - - - - - - star shaped - - 2009-07-01T01:48:19Z - A shape quality inhering in a bearer by virtue of the bearer's being arranged like rays or radii; radiating from a common center. - George Gkoutos - PATO:0002065 - quality - stellate - - - - - - - A shape quality inhering in a bearer by virtue of the bearer's being arranged like rays or radii; radiating from a common center. - PATOC:me - - - - - - - - - - altered number of - - 2009-09-21T10:41:58Z - George Gkoutos - Having extra or fewer parts. - PATO:0002083 - quality - - - - - - Having extra or fewer parts. - PATOC:GVG - - - - - - - - - - peripheral - - 2009-10-05T02:58:16Z - A positional quality inhering in a bearer by virtue of the bearer's being at the edge or boundary of a related entity. - PATO:0002107 - george - quality - - - - - - - A positional quality inhering in a bearer by virtue of the bearer's being at the edge or boundary of a related entity. - PATOC:GVG - - - - - - - - - - molecular quality - - 2010-03-10T03:18:15Z - A quality which inheres in a molecular entity, a single molecule, atom, ion, radical etc. - George Gkoutos - PATO:0002061 - PATO:0002182 - quality - relational molecular quality - - - - A quality which inheres in a molecular entity, a single molecule, atom, ion, radical etc. - PATOC:GVG - - - - - - - - - - bilobed - - 2010-07-08T01:54:08Z - A lobed quality inhering in a bearer by virtue of the bearer's being divided into or having two lobes. - PATO:0002214 - george - quality - - - - - - A lobed quality inhering in a bearer by virtue of the bearer's being divided into or having two lobes. - thefreedictionary:http://www.thefreedictionary.com/bilobed - - - - - - - - - - fan-shaped - - 2010-07-09T01:43:42Z - A quality inhering in a bearer that is shaped in the form of a fan. - PATO:0002219 - fan-like - george - quality - - - - - A quality inhering in a bearer that is shaped in the form of a fan. - thefreedictionary:http://www.thefreedictionary.com/fan-shaped - - - - - - - - - - organization quality - - 2010-09-16T10:22:52Z - A structural quality inhering in a bearer by virtue of the bearer's being arranged in a systematic fashion. - PATO:0002264 - george - quality - - - - - A structural quality inhering in a bearer by virtue of the bearer's being arranged in a systematic fashion. - PATOC:GVG - - - - - - - - - - centered - - 2010-10-05T01:09:32Z - A positional quality inhering in a bearer by virtue of the bearer's being located in a position equidistant from edges. - PATO:0002268 - george - quality - - - - - A positional quality inhering in a bearer by virtue of the bearer's being located in a position equidistant from edges. - PATOC:OREGON - - - - - - - - - - increased quality - - - - - - - - - - - - - - - - - - - 2011-06-16T06:39:43Z - A quality that has a value that is increased compared to normal or average. - George Gkoutos - PATO:0002300 - quality - - - - A quality that has a value that is increased compared to normal or average. - PATOC:GVG - - - - - - - - - - decreased quality - - - - - - - - - - - - - - - - - - - 2011-06-16T06:40:15Z - A quality that has a value that is decreased compared to normal or average. - George Gkoutos - PATO:0002301 - quality - - - - A quality that has a value that is decreased compared to normal or average. - PATOC:GVG - - - - - - - - - - decreased process quality - - - - - - - - - - - - - - - - - - - - 2011-06-16T06:50:59Z - A quality of a process that has a value that is decreased compared to normal or average. - George Gkoutos - PATO:0002302 - quality - - - - A quality of a process that has a value that is decreased compared to normal or average. - PATOC:GVG - - - - - - - - - - decreased object quality - - - - - - - - - - - - - - - - - - - - 2011-06-16T06:51:54Z - A quality of an object that has a value that is decreased compared to normal or average. - George Gkoutos - PATO:0002303 - quality - - - - A quality of an object that has a value that is decreased compared to normal or average. - PATOC:GVG - - - - - - - - - - increased process quality - - - - - - - - - - - - - - - - - - - - 2011-06-16T06:53:08Z - A quality of a process that has a value that is increased compared to normal or average. - George Gkoutos - PATO:0002304 - quality - - - - A quality of a process that has a value that is increased compared to normal or average. - PATOC:GVG - - - - - - - - - - increased object quality - - - - - - - - - - - - - - - - - - - - 2011-06-16T06:54:01Z - A quality of an object that has a value that is increased compared to normal or average. - George Gkoutos - PATO:0002305 - quality - - - - A quality of an object that has a value that is increased compared to normal or average. - PATOC:GVG - - - - - - - - - - superelliptic - - 2011-10-12T12:45:16Z - A shape constituting a transition between a rectangle and a circle; a closed curve, of which the circle and ellipse are special cases, whose parametric equation is x = a.cos2/rt, y = b.cos2/rt - George Gkoutos - Lamé curve - PATO:0002318 - quality - - - - A shape constituting a transition between a rectangle and a circle; a closed curve, of which the circle and ellipse are special cases, whose parametric equation is x = a.cos2/rt, y = b.cos2/rt - wiktionary:superellipse - - - - - - - - - - temporal distribution quality - - 2011-11-22T01:12:28Z - A temporal distribution pattern of process occurrences within a regulation/reference process. - George Gkoutos - PATO:0002323 - quality - - - - - A temporal distribution pattern of process occurrences within a regulation/reference process. - PATOC:LC - - - - - - - - - - offset quality - - 2011-11-23T11:46:00Z - George Gkoutos - PATO:0002324 - The temporal relation between the end of the process with respect to a reference process. - quality - - - - - PATOC:LC - The temporal relation between the end of the process with respect to a reference process. - - - - - - - - - - onset quality - - 2011-11-23T11:47:34Z - George Gkoutos - PATO:0002325 - The temporal relation between the start of the process with respect to a reference process. - quality - - - - - PATOC:LC - The temporal relation between the start of the process with respect to a reference process. - - - - - - - - - - shortened - - 2012-04-18T06:31:29Z - A quality inhering in a bearer by virtue of the bearer's length being notably lower than its width. - PATO:0002364 - gkoutos - quality - - - - - A quality inhering in a bearer by virtue of the bearer's length being notably lower than its width. - PATOC:GVG - - - - - - - - - - acinus - - 2012-07-05T14:58:05Z - Having a shape that resembles a many-lobed "berry," such as a raspberry. - PATO:0002378 - gkoutos - quality - - - - - - Having a shape that resembles a many-lobed "berry," such as a raspberry. - wikipedia:https://en.wikipedia.org/wiki/Acinus - - - - - - - - - - cell population phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - CMPO:0000002 - A quality that that inheres in a population of cells - cell population phenotype - - - - - - - - - cellular phenotype - A quality that inheres in or specifically depends on a cellular process, a cell population, a whole cell or a subcellular structure. - cellular phenotype - - - - - - - - - cell morphology phenotype - - - - - - - - - - - - - - - - - - - CMPO:0000005 - A collection of qualities that inhere in the whole cell relating to the cell's shape, size or structure - cell morphology - - - - - - - - - cell process phenotype - - - - - - - - - - - - - - - - - - A quality that inheres in a cellular process - CMPO:0000007 - cell physiology phenotype - cell process phenotype - - - - - - - - - cell component number phenotype - - - - - - - - - - - - - - - - - - - - - - An increase or decrease in the number of specified components within a cell - CMPO:0000008 - cell component number - - - - - - - - - cell component size phenotype - - - - - - - - - - - - - - - - - - A collection of size qualities that inhere in a cellular component - CMPO:0000010 - cell component size - - - - - - - - - cell component shape phenotype - - - - - - - - - - - - - - - - - - A collection of shape qualities that inhere in a cellular component - CMPO:0000011 - cell component shape - - - - - - - - - cell component structure phenotype - - - - - - - - - - - - - - - - - - CMPO:0000012 - A collection of structure qualities that inhere in a cellular component - cell component structure - - - - - - - - - cell viability phenotype - - - - - - - - - - - - - - - - - - CMPO:0000013 - A phenotype relating to the ability of a cell survive or to develop normally - cell viability - - - - - - - - - viable cell phenotype - - - - - - - - - - - - - - - - - - CMPO:0000014 - A cell phenotype where the cell is viable - viable cell - - - - - - - - - inviable cell phenotype - - - - - - - - - - - - - - - - - - CMPO:0000015 - A cell phenotype where the cell is not viable - inviable cell - - - - - - - - - cell nucleation phenotype - - - - - - - - - - - - - - - - - - CMPO:0000016 - A nucleation quality that inheres in the whole cell - cell nucleation - - - - - - - - - mononuclear cell phenotype - - - - - - - - - - - - - - - - - - CMPO:0000017 - mononuclear cell - - - - - - - - - multinucleated cell phenotype - - - - - - - - - - - - - - - - - - CMPO:0000018 - A multinucleate quality that inheres in a cell - polynuclear cell - multinucleated cell - - - - - - - - - cytoskeletal phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A collection of qualities that inhere in any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice. - CMPO:0000020 - cytoskeletal phenotype - - - - - - - - - endoplasmic reticulum phenotype - - - - - - - - - - - - - - - - - - - - - - - CMPO:0000021 - A collection of qualities that inhere in any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. - endoplasmic reticulum phenotype - - - - - - - - - golgi phenotype - - - - - - - - - - - - - - - - - - - - - - - CMPO:0000022 - A collection of qualities that inhere in any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack - golgi phenotype - - - - - - - - - mitochondrion phenotype - - - - - - - - - - - - - - - - - - A collection of qualities that inhere in any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. - mitochondrial part phenotype - CMPO:0000023 - mitochondrion phenotype - - - - - - - - - nuclear phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - CMPO:0000024 - A collection of qualities that inhere in any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. - nuclear phenotype - - - - - - - - - organelle shape phenotype - - - - - - - - - - - - - - - - - - A collection of qualities that inhere in a cellular organelle relating to the organelle's shape - CMPO:0000026 - organelle shape - - - - - - - - - nucleus shape phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - nuclear shape - A collection of qualities that inhere in the nucleus relating to the ratios of distances between its features (points, edges, surfaces and also holes etc). - - - - - - - - - cell adhesion phenotype - - - - - - - - - - - - - - - - - - A phenotype where the attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules is observed - CMPO:0000028 - cell adhesion phenotype - - - - - - - - - cell cycle phenotype - - - - - - - - - - - - - - - - - - - - - - - CMPO:0000029 - A collection of qualities that inhere the cell cycle - cell cycle phenotype - - - - - - - - - cell death phenotype - - - - - - - - - - - - - - - - - - CMPO:0000030 - A phenotype where the cell death process process is observed - PMID:20360735 - cell death phenotype - - - - - - - - - cell membrane organisation phenotype - - - - - - - - - - - - - - - - - - A phenotype observation of a process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. - CMPO:0000032 - cell membrane organisation phenotype - - - - - - - - - cell migration phenotype - - - - - - - - - - - - - - - - - - PMID:20360735 - A phenotype of a cell involving its translation from one location to another - CMPO:0000033 - cell migration phenotype - - - - - - - - - cell growth phenotype - - - - - - - - - - - - - - - - - - A phenotype observation of the process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. - CMPO:0000035 - cell growth phenotype - - - - - - - - - chromosome segregation phenotype - - - - - - - - - - - - - - - - - - A phenotype observation of the process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the alignment of chromosomes at the metaphase plate, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. - CMPO:0000036 - chromosome segregation phenotype - - - - - - - - - metabolic process phenotype - - - - - - - - - - - - - - - - - - CMPO:0000037 - A phenotype observation of chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. - metabolic process phenotype - - - - - - - - - organelle localization phenotype - - - - - - - - - - - - - - - - - - A phenotype observations where any process in which an organelle is transported to, and/or maintained in, a specific location. - CMPO:0000038 - organelle localization phenotype - - - - - - - - - regulation of metabolic process phenotype - - - - - - - - - - - - - - - - - - A phenotype observation where a process modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. - CMPO:0000039 - regulation of metabolic process phenotype - - - - - - - - - regulation of signal transduction phenotype - - - - - - - - - - - - - - - - - - A phenotype observation of a process that modulates the frequency, rate or extent of signal transduction. - CMPO:0000040 - regulation of signal transduction phenotype - - - - - - - - - transport phenotype - - - - - - - - - - - - - - - - - - A phenotype observation of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. - CMPO:0000041 - transport phenotype - - - - - - - - - increased cell component number phenotype - - - - - - - - - - - - - - - - - - - - - - An increased number of specified cellular components relative to normal - CMPO:0000042 - increased cell component number - - - - - - - - - decreased cell component number phenotype - - - - - - - - - - - - - - - - - - - - - - CMPO:0000043 - A decrease in number of specified cellular components relative to normal - decreased cell component number - - - - - - - - - apoptotic DNA fragmentation phenotype - - - - - - - - - - - - - - - - - - A phenotype observation where the cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments. - apoptotic DNA - CMPO:0000047 - apoptotic DNA fragmentation - - - - - - - - - apoptotic cell shape phenotype - - - - - - - - - - - - - - - - - - - apoptotic cell shape - dispersed outline with blobby protrusions - CMPO:0000048 - A phenotype observation at the level of the cell shape where the cell is apoptotic - - - - - - - - - aggregated cells in population - - - - - - - - - - - - - - - - - - cell aggregates - cell islands - CMPO:0000049 - aggregated cells - Groups of cells gathered or tending to gather into a mass or whole. - aggregated cells in population - clustered cells - - - - - - - - - altered cell number in population - - - - - - - - - - - - - - - - - - Number of cells in a population phenotype - CMPO:0000050 - cell number in population - - - - - - - - - increased cell numbers - - - - - - - - - - - - - - - - - - The population has an increased number of cells with respect to normal - CMPO:0000051 - increased cell numbers - - - - - - - - - decreased cell numbers - - - - - - - - - - - - - - - - - - CMPO:0000052 - reduced cell numbers - decreased cells - fewer cells - The population has a decreased number of cells with respect to normal - decreased cell numbers - less cells - - - - - - - - - more cells in S - - - - - - - - - - - - - - - - - - CMPO:0000053 - increased number of cells in S phase mitosis - - - - - - - - - cell population phenotype by process - - - - - - - - - - - - - - - - - - A population of cells where a specifcied biological process is occuring or is observed. - CMPO:0000054 - cell population process - - - - - - - - - more cells in G1 - - - - - - - - - - - - - - - - - - CMPO:0000055 - increased cell numbers in G1 - - - - - - - - - more cells in G2M - - - - - - - - - - - - - - - - - - increased number of cells in G2M - increased mitotic index - CMPO:0000056 - - - - - - - - - fewer cells in G1 - - - - - - - - - - - - - - - - - - CMPO:0000057 - decreased number of cells in G1 phase - less cells in G1 - - - - - - - - - fewer cells in G2M - - - - - - - - - - - - - - - - - - less cells in G2M - decreased mitotic index - CMPO:0000058 - decreased number of cells in G2M phase - - - - - - - - - fewer cells in S - - - - - - - - - - - - - - - - - - decreased number of cells in S phase - CMPO:0000059 - decreased number of cells in S - less cells in S - - - - - - - - - decreased number of focal adhesion phenotype - - - - - - - - - - - - - - - - - - - - - - decreased focal adhesion abundance - A phenotype observation at the level of focal adhesions where the components number has decreased. - CMPO:0000063 - decreased number of focal adhesion - - - - - - - - - centrally located focal adhesion phenotype - - - - - - - - - - - - - - - - - - PMID:19667130 - CMPO:0000064 - A phenotype observation where the focal adhesion is located in a position equidistant from the edges of the cell - centrally located focal adhesion - - - - - - - - - cell component position phenotype - - - - - - - - - - - - - - - - - - CMPO:0000065 - A phenotype observation at the level of a cellular component relating to the components position in the cell - cell component position - - - - - - - - - peripheral focal adhesion phenotype - - - - - - - - - - - - - - - - - - CMPO:0000066 - PMID:19667130 - A phenotype observation where the focal adhesions's position is at the edge or boundary of a related entity. - peripheral focal adhesion - - - - - - - - - decreased number of filopodia phenotype - - - - - - - - - - - - - - - - - - - - - - A phenotype observation at the level of filopodia where the components number has decreased. - CMPO:0000067 - decreased number of filopodia - fewer filopodia - - - - - - - - - decreased number of microtubules phenotype - - - - - - - - - - - - - - - - - - - - - - fewer microtubules - CMPO:0000068 - A phenotype observation at the level of microtubules where the components number has decreased. - decreased number of microtubules - - - - - - - - - decreased number of dendritic branches phenotyope - - - - - - - - - - - - - - - - - - - - - - CMPO:0000069 - A phenotype observation at the level of dendritic branches where the components number has decreased. - - - - - - - - - cell with projections - - PMID:20531400 - CMPO:0000071 - Single cell with protrusions - cell with protrusions - - - - - - - - - increased number of cell projections phenotype - - - - - - - - - - - - - - - - - - - - - - An increase in number of any cell projection relative to normal - CMPO:0000072 - increased number of cell projections - - - - - - - - - more cells with projections - - - - - - - - - - - - - - - - - - CMPO:0000073 - increased number of cells in population with projections - - - - - - - - - decreased number of cell projections phenotype - - - - - - - - - - - - - - - - - - - - - - A phenotype observation at the level of cell projections where the components number has decreased. - CMPO:0000074 - decreased number of cell projections - - - - - - - - - fewer cells with projections - - - - - - - - - - - - - - - - - - CMPO:0000075 - decreased number of cells in population with projections - - - - - - - - - increased number of filopodia - - - - - - - - - - - - - - - - - - - - - - CMPO:0000076 - more filopodia - A phenotype observation at the level of filopodia where the components number has increased. - - - - - - - - - elongated cell phenotype - - - - - - - - - - - - - - - - - - - A phenotype observation at the level of the cell shape where the cell is elongated, with a length notably greater than its width - CMPO:0000077 - bipolar cell - elongated cell - - - - - - - - - elongated cells in population - - - - - - - - - - - - - - - - - - - Cells in population with a length notably greater than their width - PMID:21893601; PMID:20531400 - CMPO:0000078 - elongated cells in population - - - - - - - - - increased number of lamellipodia phenotype - - - - - - - - - - - - - - - - - - - - - - A phenotype observation at the level of lamellipodia where the components number has increased. - CMPO:0000080 - increased number of lamellipodia - lamellipodium phenotype - - - - - - - - - decreased number of lamellipodia phenotype - - - - - - - - - - - - - - - - - - - - - - A phenotype observation at the level of lamellipodia where the components number has decreased. - CMPO:0000081 - decreased number of lamellipodia - - - - - - - - - more lamellipodia cells - - - - - - - - - - - - - - - - - - CMPO:0000083 - increased lamellipodia cells in population phenotype - - - - - - - - - fewer lamellipodia cells - - - - - - - - - - - - - - - - - - CMPO:0000084 - decreased lamellipodia cells in population phenotype - - - - - - - - - cell ploidy phenotype - - - - - - - - - - - - - - - - - - A phenotype observation at the level of the whole cell relating to the cell's ploidy - CMPO:0000085 - cell ploidy - - - - - - - - - polyploid cell phenotype - - - - - - - - - - - - - - - - - - CMPO:0000086 - A cell phenotype with more than two homologous sets of chromosomes. - polyploid cell - - - - - - - - - S phase mitotic phenotype - - - - - - - - - - - - - - - - - - - CMPO:0000087 - A phenotype observation at the level of athe S phase of the mitotic cell cycle - S phase mitotic phenotype - - - - - - - - - G1 phase mitotic phenotype - - - - - - - - - - - - - - - - - - - A phenotype observation at the level of a G1 phase of the mitotic cell cycle - CMPO:0000088 - G1 phase mitotic phenotype - - - - - - - - - G2/M transition phenotype - - - - - - - - - - - - - - - - - - CMPO:0000089 - A phenotype observation at the level of the G2/M transition of the mitotic cell cycle - G2/M transition phenotype - - - - - - - - - cell cycle phase phenotype - - - - - - - - - - - - - - - - - - A phenotype observation at the level of a cell cycle phase - CMPO:0000090 - cell cycle phase phenotype - - - - - - - - - more polyploid cells - - - - - - - - - - - - - - - - - - CMPO:0000091 - increased number of polyploid cells in population - - - - - - - - - increased number of focal adhesion phenotype - - - - - - - - - - - - - - - - - - - - - - A phenotype observation at the level of focal adhesions where the components number has increased. - increased focal adhesion abundance - CMPO:0000092 - increased number of focal adhesion - - - - - - - - - increased number of nucleoli phenotype - - - - - - - - - - - - - - - - - - - - - - CMPO:0000093 - A phenotype observation at the level of nucleoli where the components number has increased. - increased number of nucleoli - - - - - - - - - decreased number of nucleoli phenotype - - - - - - - - - - - - - - - - - - - - - - CMPO:0000094 - A phenotype observation at the level of nucleoli where the components number has decreased. - decreased number of nucleoli - - - - - - - - - more cells with decreased number of nucleoli - - - - - - - - - - - - - - - - - - CMPO:0000095 - more cells with decreased number of nucleoli - - - - - - - - - more cells with increased number of nucleoli - - - - - - - - - - - - - - - - - - CMPO:0000096 - increased number of nucleoli in population phenotype - - - - - - - - - increased number of microtubules phenotype - - - - - - - - - - - - - - - - - - - - - - A phenotype observation at the level of microtubules where the components number has increased. - more microtubules - CMPO:0000097 - increased number of microtubules - - - - - - - - - phagosomes phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - phagosomes - phagosomes present phenotype - A phenotype observation at the level of the phagosomes, a membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis. - CMPO:0000102 - - - - - - - - - phagosomes absent phenotype - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation where phagosomes are absent - CMPO:0000103 - phagosomes absent - - - - - - - - - actin filament phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation at the level of the actin filaments, a filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. - CMPO:0000104 - actin filament phenotype - - - - - - - - - increased number of actin filament phenotype - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation at the level of actin filaments where the components number has increased. - PMID:20531400 - increased number of actin filament - more total actin - PMID: 21893601 - actin fiber cells - CMPO:0000105 - more actin - - - - - - - - - decreased number of actin filament phenotype - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation at the level of actin filaments where the components number has decreased. - PMID: 21893601 - CMPO:0000106 - less total actin - less actin - decreased number of actin filament - - - - - - - - - more actin filament cells - - - - - - - - - - - - - - - - - - CMPO:0000107 - increased number of actin filament cells in population - - - - - - - - - fewer actin filament cells - - - - - - - - - - - - - - - - - - decreased number of actin filament cells - CMPO:0000108 - decreased number of actin filament phenotypes in population - - - - - - - - - centered cytoskeleton phenotype - - - - - - - - - - - - - - - - - - - CMPO:0000109 - A phenotype observation where the cytoskeleton is located in a position equidistant from the edges of the cell - centered cytoskeleton - - - - - - - - - centered nucleus phenotype - - - - - - - - - - - - - - - - - - - CMPO:0000110 - A phenotype observation where the nucleus is located in a position equidistant from the edges of the cell - centered nucleus - - - - - - - - - dispersed nucleus phenotype - - - - - - - - - - - - - - - - - - - CMPO:0000111 - A phenotype observation where the nucleus is distributed or spread over a considerable extent. - dispersed nucleus - - - - - - - - - apoptopic nucleus phenotype - - - - - - - - - - - - - - - - - - - CMPO:0000112 - A phenotype observation at the level of nucleus consisting of blebbing of the nucleus and DNA fragmentation due to the cell undergoing a specific form of programmed cell death termed apoptosis. - apoptopic nucleus - - - - - - - - - deformed nucleus - - - - - - - - - - - - - - - - - - A phenotype observation where the nucleus is distorted in form - CMPO:0000113 - - - - - - - - - peripheral nucleus phenotype - - - - - - - - - - - - - - - - - - - A phenotype observation where the nucleus's position is at the edge or boundary of a related entity. - CMPO:0000114 - peripheral nucleus - - - - - - - - - peripheral cytoskeleton phenotype - - - - - - - - - - - - - - - - - - - CMPO:0000115 - A phenotype observation where the cytoskeleton's position is at the edge or boundary of a related entity. - peripheral cytoskeleton - - - - - - - - - abnormal cell shape phenotype - - - - - - - - - - - - - - - - - - - - - - - CMPO:0000116 - A phenotype observation at the level of the cell shape where the shape is abnormal - abnormal cell shape - - - - - - - - - bilobed nucleus phenotype - - - - - - - - - - - - - - - - - - bilobed - CMPO:0000117 - A lobed quality inhering in a nucleus by virtue of the nucleus being divided into or having two lobes. - bilobed nucleus - - - - - - - - - round cell phenotype - - - - - - - - - - - - - - - - - - - circular cell - PMID:21893601 - not spreading cell - CMPO:0000118 - spherical cell - A phenotype observation at the level of the cell shape where the cell is round - low eccentricity cell - round cell - - - - - - - - - elongated focal adhesion - - - - - - - - - - - - - - - - - - CMPO:0000119 - A phenotype observation of the length of the focal adhesion is notably higher than the width. - long focal adhesion - - - - - - - - - elongated nucleus - - - - - - - - - - - - - - - - - - long nucleus - A phenotype observation of the length of the nucleus is notably higher than the width. - CMPO:0000120 - - - - - - - - - arrow shaped cell phenotype - - - - - - - - - - - - - - - - - - - CMPO:0000121 - A phenotype observation at the level of the cell shape where the cell is arrow shaped, with a wide front and a sharp tail, displaying monopolar cell growth - triangular shaped cell - - - - - - - - - triangular shaped cell phenotype - - - - - - - - - - - - - - - - - - - CMPO:0000122 - A phenotype observation at the level of the cell shape where the cell has a triangular shape, with a wide front and a sharp tail, displaying cell motility - arrow shaped cell - triangular shaped cell - - - - - - - - - round nucleus phenotype - - - - - - - - - - - - - - - - - - round nucleus - circular nucleus - CMPO:0000123 - A phenotype observation where the shape of the nucleus has every part of the surface or the circumference equidistant from the center. - round nucleus - - - - - - - - - nuclear body phenotype - - - - - - - - - - - - - - - - - - A phenotype observation at the level of the nuclear body, an extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. - CMPO:0000125 - nuclear body - - - - - - - - - increased nuclear body size phenotype - - - - - - - - - - - - - - - - - - - - CMPO:0000126 - A phenotype observation where the nuclear body size is relatively high. - PMID:22884692 - increased nuclear body size - - - - - - - - - decreased nuclear body size phenotype - - - - - - - - - - - - - - - - - - - - CMPO:0000127 - PMID:22884692 - A phenotype observation where the nuclear body size is relatively low. - decreased nuclear body size - - - - - - - - - increased cell size phenotype - - - - - - - - - - - - - - - - - - - CMPO:0000128 - big cell - A phenotype observation at the level of the cell size where a cell is larger with respect to normal/wild-type - increased cell area - large cell - PMID:20531400 - increased cell size - - - - - - - - - decreased cell size phenotype - - - - - - - - - - - - - - - - - - - CMPO:0000129 - A phenotype observation at the level of the cell size where a cell is smaller with respect to normal/wild-type - small cell - - - - - - - - - decreased golgi volume phenotype - - - - - - - - - - - - - - - - - - CMPO:0000130 - A phenotype observation at the level of the golgi where the golgi's volume has decreased. - decreased golgi volume - - - - - - - - - increased golgi volume phenotype - - - - - - - - - - - - - - - - - - A phenotype observation at the level of the golgi where the golgi's volume has increased. - CMPO:0000131 - increased golgi volume - - - - - - - - - decreased cilium length phenotype - - - - - - - - - - - - - - - - - - - CMPO:0000132 - A phenotype observation at the level of a cilium where the components length has decreased. - decreased cilium length - - - - - - - - - increased cilium length phenotype - - - - - - - - - - - - - - - - - - - A phenotype observation at the level of a cilium where the components length has increased. - CMPO:0000133 - increased cilium length - - - - - - - - - decreased size of focal adhesion phenotype - - - - - - - - - - - - - - - - - - CMPO:0000134 - A phenotype observation where the size of the focal adhesion has decreased. - decreased size of focal adhesion - - - - - - - - - increased size of focal adhesion phenotype - - - - - - - - - - - - - - - - - - A phenotype observation where the size of the focal adhesion has increased. - CMPO:0000135 - increased size of focal adhesion - - - - - - - - - decreased focal adhesion area phenotype - - - - - - - - - - - - - - - - - - pmid:19667130 - CMPO:0000136 - small focal adhesion - A phenotype observation where the area of the focal adhesion has decreased. - decreased focal adhesion area - - - - - - - - - increased focal adhesion area phenotype - - - - - - - - - - - - - - - - - - large focal adhesion - A phenotype observation where the area of the focal adhesion has increased. - CMPO:0000137 - pmid:19667130 - increased focal adhesion area - - - - - - - - - decreased focal adhesion length phenotype - - - - - - - - - - - - - - - - - - CMPO:0000138 - pmid:19667130 - short focal adhesion - A phenotype observation where the length of the focal adhesion has decreased. - decreased focal adhesion length - - - - - - - - - increased focal adhesion length phenotype - - - - - - - - - - - - - - - - - - A phenotype observation where the length of the focal adhesion has increased. - CMPO:0000139 - increased focal adhesion length - - - - - - - - - increased nucleus size phenotype - - - - - - - - - - - - - - - - - - - large nucleus - increased DNA area - PMID:20531400 - A phenotype observation where the size of the nucleus has increased - large nuclei - PMID:20360735 - CMPO:0000140 - increased nucleus size - - - - - - - - - decreased nucleus size phenotype - - - - - - - - - - - - - - - - - - - PMID:21893601 - CMPO:0000141 - decreased nucleus size - small nucleus - decreased DNA area - A phenotype observation where the size of the nucleus has decreased - PMID:20360735 - - - - - - - - - increased nuclei size in G1 phenotype - - - - - - - - - - - - - - - - - - A phenotype of a cell that has both an increased nuclei size phenotypes and a G1 phase phenotype - CMPO:0000143 - increased nuclei size in G1 - - - - - - - - - decreased nuclei size in G1 phenotype - - - - - - - - - - - - - - - - CMPO:0000144 - A phenotype of a cell that has both a decreased nuclei size phenotypes and a G1 phase phenotype - decreased nuclei size in G1 - small nuclei in G1 - - - - - - - - - increased thickness of dendritic branches phenotype - - - - - - - - - - - - - - - - - - A phenotype observation where the thickness of the dendritic branches has increased. - CMPO:0000145 - increased thickness of dendritic branches - - - - - - - - - decreased thickness of dendritic branches - - - - - - - - - - - - - - - - - - CMPO:0000146 - A phenotype observation where the thickness of the dendritic branches has decreased. - - - - - - - - - disorganized microtubules phenotype - - - - - - - - - - - - - - - - - - - pmid:21893601 - microtubule disorganised - A phenotype observation where the microtublue structure is disorganised - CMPO:0000147 - disorganized microtubules - - - - - - - - - podosome phenotype - - - - - - - - - - - - - - - - - - A phenotype observation at the level of podosomes, an actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell. - CMPO:0000148 - podosome - - - - - - - - - radial cytoskeleton phenotype - - - - - - - - - - - - - - - - - - - CMPO:0000149 - A phenotype observation where the cytoskeleton is symmetric, having equal proportions around a central point or axis. - radial cytoskeleton - - - - - - - - - organelle phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Phenotype observation organised by specific named organelles. - CMPO:0000150 - - - - - - - - - fragmented endoplasmic reticulum phenotype - - - - - - - - - - - - - - - - - - broken endoplasmic reticulum - A phenotype observation where the structure of the endoplasmic reticulum is fragmented or broken. - CMPO:0000151 - fragmented endoplasmic reticulum - - - - - - - - - fragmented golgi phenotype - - - - - - - - - - - - - - - - - - broken golgi - A phenotype observation at the level of the golgi where the golgi's structure is broken - CMPO:0000152 - broken golgi phenotype - fragmented golgi - - - - - - - - - fragmented mitochondria phenotype - - - - - - - - - - - - - - - - - - broken mitochondria - A phenotype observation where the structure of the mitochondria is fragmented or broken. - CMPO:0000153 - fragmented mitochondria - - - - - - - - - bright nuclei phenotype - - - - - - - - - - - - - - - - - - PMID:20531400 - CMPO:0000154 - A phenotype observation where the nuclear's color brightness is relatively high. - bright nuclei - - - - - - - - - fragmented nucleus phenotype - - - - - - - - - - - - - - - - - - - A phenotype observation where the structure of the nucleus is fragmented or broken. - broken nucleus - CMPO:0000155 - fragmented nucleus - - - - - - - - - graped micronucleus phenotype - - - - - - - - - - - - - - - - - - A phenotype observation where nuclear envelopes form around single chromosomes or small sets of chromosomes. Forming a grape like structure - CMPO:0000156 - pmid:20360735 - Mitocheck -Publication: http://www.ncbi.nlm.nih.gov/pubmed/20360735 -Micronucleation, i.e. presumably nuclear envelopes around single chromosomes or small sets of chromosomes. - grape - graped micronucleus - - - - - - - - - abnormal nucleus shape phenotype - - - - - - - - - - - - - - - - - - - - - - strange nuclear shape - abnormal nuclear shape - PMID:20360735 - A phenotype observation where the shape of the nucleus is abnormal - - - - - - - - - decreased nuclei size in G2/M phenotype - - - - - - - - - - - - - - - - CMPO:0000158 - A phenotype observation at the level of the G2/M transition of the mitotic cell cycle where the nuclei are decreased in size with respect to normal - decreased nuclei size in G2/M - - - - - - - - - absence of cellular component phenotype - - - - - - - - - - - - - - - - - - - - - - CMPO:0000159 - A phenotype observation at the level of a cellular component where the cell component is absent - absence of cellular component - - - - - - - - - cell population viability phenotype - - CMPO:0000160 - cell viability in population phenotype - A phenotype of a cell population relating to the ability of the cells to live and develop normally - - - - - - - - - increased cell viability in population - - - - - - - - - - - - - - - - - - CMPO:0000161 - increased number of viable cell phenotype in a population - increased cell viability in population - - - - - - - - - decreased cell viability in population - - - - - - - - - - - - - - - - - - decreased cell viability in population - decreased number of viable cell phenotype in a population - CMPO:0000162 - - - - - - - - - cell population phenotype by morphology - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - CMPO:0000163 - A population phenotype relating to the size, shape or structure of the cells within a population - cell population morphology - - - - - - - - - absence of cytokinesis phenotype - - - - - - - - - - - - - - - - - - - - - - - CMPO:0000164 - A phenotype that results in the absence of cytokinesis - absence of cytokinesis - - - - - - - - - cytokinesis phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation at the level of cytokinesis - CMPO:0000165 - cytokinesis phenotype - - - - - - - - - cell division phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - CMPO:0000166 - A phenotype observation of the process resulting in the physical partitioning and separation of a cell into daughter cells. - cell division phenotype - - - - - - - - - increased rate of cell division phenotype - - - - - - - - - - - - - - - - - - faster cell division - A phenotype where the cell division process occurs at a higher rate - CMPO:0000168 - increased rate of cell division - - - - - - - - - decreased rate of cell division phenotype - - - - - - - - - - - - - - - - - - slower cell division - A phenotype where the cell division process occurs at a lower rate - CMPO:0000169 - decreased rate of cell division - - - - - - - - - telomerase activity phenotype - - - - - - - - - - - - - - - - - - CMPO:0000170 - A phenotype observation of the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence. - telomerase activity phenotype - - - - - - - - - decreased telomerase activity phenotype - - - - - - - - - - - - - - - - - - A phenotype observation where the occurane of telomerase activity is decreased - CMPO:0000171 - decreased telomerase activity - - - - - - - - - increased telomerase activity phenotype - - - - - - - - - - - - - - - - - - A phenotype observation where the occurane of telomerase activity is increased - CMPO:0000172 - increased telomerase activity - - - - - - - - - G0/1 arrested phenotype - - - - - - - - - - - - - - - - - - - CMPO:0000173 - (from GO) Under certain conditions, cells exit the cell cycle during G1 and remain in the G0 state as nongrowing, non-dividing (quiescent) cells. - A phenotype of a cell that is arrested at the G0/1 transition - G0/1 arrested - - - - - - - - - polarized endoplasmic reticulum phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - polarized endoplasmic reticulum - A phenotype observation where the endoplasmic reticulum is oriented in the cell with extremities at either end of the main axis. - CMPO:0000174 - polarized endoplasmic reticulum - - - - - - - - - molecular component phenotype - - - - - - - - - - - - - - - - - - A quality that inheres in a molecular component of a cell - CMPO:0000175 - molecular component phenotype - - - - - - - - - cell DNA phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - CMPO:0000176 - A phenotype observation at the level of the cell DNA - cell DNA phenotype - - - - - - - - - misshapen DNA - - - - - - - - - - - - - - - - - - - - - - This phenotype often results in a nucleus with an irregular shape phenotype. - A shape quality that inheres in a DNA molecule where the shape of the molecule is abnormal. - CMPO:0000177 - - - - - - - - - site of double-strand break phenotype - - - - - - - - - - - - - - - - - - A phenotype observation at the level of the site of double-strand break, a region of a chromosome at which a DNA double-strand break has occurred. - CMPO:0000180 - site of double-strand break - - - - - - - - - decreased number of site of double-strand break phenotype - - - - - - - - - - - - - - - - - - - - - - A phenotype observation at the level of double strand breaks where the components number has decreased. - CMPO:0000181 - decreased number of site of double-strand break - - - - - - - - - increased number of site of double-strand break phenotype - - - - - - - - - - - - - - - - - - - - - - A phenotype observation where the number of double-strand breaks has increased - CMPO:0000182 - increased number of site of double-strand break - - - - - - - - - cell-matrix adhesion phenotype - - - - - - - - - - - - - - - - - - CMPO:0000185 - cell-matrix adhesion phenotype - - - - - - - - - increased cell component size phenotype - - - - - - - - - - - - - - - - - - CMPO:0000186 - A phenotype observation at the level of a cellular component where the components size has increased. - increased cell component size - - - - - - - - - decreased cell component size phenotype - - - - - - - - - - - - - - - - - - CMPO:0000187 - A phenotype observation at the level of a cellular component where the components size has decreased. - decreased cell component size - - - - - - - - - cell spreading phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - substrate adhesion-dependent cell spreading phenotype - A phenotype observation where the morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate. - CMPO:0000188 - cell spreading phenotype - - - - - - - - - cellular development phenotype - - - - - - - - - - - - - - - - - - CMPO:0000189 - A phenotype observation of a biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition. - cellular development phenotype - - - - - - - - - decreased number of axons phenotype - - - - - - - - - - - - - - - - - - - - - - A phenotype observation at the level of axons where the components number has decreased. - CMPO:0000190 - decreased number of axons - - - - - - - - - increased number of axons phenotype - - - - - - - - - - - - - - - - - - - - - - A phenotype observation at the level of axons where the components number has increased. - CMPO:0000191 - increased number of axons - - - - - - - - - mitotic process phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - CMPO:0000194 - A phenotype observation at the level of the mitotic cell cycle - mitotic process phenotype - - - - - - - - - arrested process phenotype - - - - - - - - - - - - - - - - - - CMPO:0000195 - A phenotype of a cell where a particular process is arrested, or ends earlier in time than expected - arrested process - - - - - - - - - M phase arrested phenotype - - - - - - - - - - - - - - - - - - - mitosis incomplete process phenotype - CMPO:0000196 - mitotic arrest - A phenotype of a cell where the M phase of mitotic cell cycle process is arrested, or ends earlier in time than expected - M phase arrested - m phase arrest - - - - - - - - - mitosis delayed phenotype - - - - - - - - - - - - - - - - - - - - - - - CMPO:0000202 - A phenotype observation where mitosis is delayed - PMID:20360735 - Mitotic delay - mitosis delayed - - - - - - - - - G2 arrested phenotype - - - - - - - - - - - - - - - - - - - CMPO:0000203 - A phenotype of a cell is arrested in G2 pahse of the cell cycle. - G2 arrested - - - - - - - - - S phase arrested phenotype - - - - - - - - - - - - - - - - - - - CMPO:0000204 - A phenotype of a cell where the S phase process is arrested, or ends earlier in time than expected - S phase arrested - - - - - - - - - increased duration of exit from mitosis phenotype - - - - - - - - - - - - - - - - - - PMID:20711181 - increased duration of exit from mitosis - prolonged mitotic exit - A phenotype observation where the duration of the exit from mitosis is increased - CMPO:0000205 - - - - - - - - - decreased duration of exit from mitosis phenotype - - - - - - - - - - - - - - - - - - CMPO:0000206 - decreased duration of exit from mitosis - - - - - - - - - G2 phase mitotic phenotype - - - - - - - - - - - - - - - - - - - CMPO:0000207 - A phenotype observation at the level of a G2 phase of the mitotic cell cycle - G2 phase mitotic phenotype - - - - - - - - - mitotic metaphase phenotype - - - - - - - - - - - - - - - - - - - A phenotype observation at the level of the mitotic metaphase of the cell cycle - CMPO:0000208 - mitotic metaphase phenotype - - - - - - - - - more mitotic metaphase cells - - - - - - - - - - - - - - - - - - CMPO:0000210 - increased number of mitotic metaphase cells in population phenotype - - - - - - - - - fewer mitotic metaphase cells - - - - - - - - - - - - - - - - - - CMPO:0000211 - decreased number of mitotic metaphase cells in population phenotype - - - - - - - - - abnormal cell cycle phenotype - - - - - - - - - - - - - - - - - - - - - - CMPO:0000212 - abnormal cell cycle - altered level of protein in cell nucleus - A phenotype where the cell cycle is in some way abnormal - - - - - - - - - binuclear cell phenotype - - - - - - - - - - - - - - - - - - CMPO:0000213 - binuclear cell - nuclei stay close together - A phenotype observation where a cell is binucleate, e.g. have two nuclei per cell - - - - - - - - - increased duration of mitotic chromosome condensation phenotype - - - - - - - - - - - - - - - - - - CMPO:0000214 - A phenotype observation where the duration of the mitotic chromosome condensation is increased - increased duration of mitotic chromosome condensation - longer mitotic chromosome condensation - - - - - - - - - decreased duration of mitotic chromosome condensation phenotype - - - - - - - - - - - - - - - - - - CMPO:0000215 - A phenotype observation where the duration of the mitotic chromosome condensation is decreased - decreased duration of mitotic chromosome condensation - - - - - - - - - absence of mitotic chromosome decondensation phenotype - - - - - - - - - - - - - - - - - - - - - - - CMPO:0000216 - A phenotype resulting from the absence of mitotic chromosome decondensation - absence of mitotic chromosome decondensation - failure in decondensation - - - - - - - - - absence of mitotic process phenotype - - - - - - - - - - - - - - - - - - - - - - CMPO:0000217 - A phenotype resulting in the absence of mitotic process - absence of mitotic process - - - - - - - - - mitotic chromosome condensation phenotype - - - - - - - - - - - - - - - - - - CMPO:0000218 - A phenotype observation at the level of mitotic chromosome condensation - mitotic chromosome condensation phenotype - - - - - - - - - mitotic chromosome decondensation phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - CMPO:0000219 - A phenotype observation at the level of mitotic chromosome decondensation - mitotic chromosome decondensation - - - - - - - - - cell apoptosis phenotype - - - - - - - - - - - - - - - - - - A phenotype where the apoptosis process is observed - CMPO:0000220 - cell apoptosis phenotype - - - - - - - - - more apoptosis in population - - - - - - - - - - - - - - - - - - CMPO:0000221 - increased number of apoptosis phenotypes in population - - - - - - - - - less apoptosis in population - - - - - - - - - - - - - - - - - - CMPO:0000222 - decreased number of apoptosis phenotypes in population - - - - - - - - - increased axon thickness phenotype - - - - - - - - - - - - - - - - - - - A phenotype observation where the thickness of the axon has increased. - CMPO:0000223 - increased axon thickness - - - - - - - - - decreased axon thickness phenotype - - - - - - - - - - - - - - - - - - - A phenotype observation where the thickness of the axon has decreased. - CMPO:0000224 - decresed axon thickness - - - - - - - - - increased axon length phenotype - - - - - - - - - - - - - - - - - - - A phenotype observation at the level of a axon where the components length has increased. - CMPO:0000227 - increased axon length - - - - - - - - - decreased axon length phenotype - - - - - - - - - - - - - - - - - - - CMPO:0000228 - A phenotype observation at the level of a axon where the components length has decreased. - decreased axon length - - - - - - - - - plasma membrane fusion occurance phenotype - - - - - - - - - - - - - - - - - - cell fusion event - CMPO:0000229 - plasma membrane fusion occurance - - - - - - - - - increased rate of cell migration process phenotype - - - - - - - - - - - - - - - - - - PMID:20360735 - CMPO:0000232 - A phenotype where the cell migration process occurs at an increased rate, typically observed as a faster moving cell - increased rate of cell migration process - - - - - - - - - decreased rate of cell migration process phenotype - - - - - - - - - - - - - - - - - - A phenotype where the cell migration process occurs at an redcued rate, typically observed as a slower moving cell - CMPO:0000233 - decreased rate of cell migration process - decreased speed of cell migration - - - - - - - - - cell movement phenotype - - - - - - - - - - - - - - - - - - A phenotype observation at the level of the whole cell relating to the cell's movement - CMPO:0000234 - cell movement - - - - - - - - - increased cell movement phenotype - - A phenotype observation at the level of the cell movement where cell movement is increased - CMPO:0000235 - increased cell movement - - - - - - - - - increased cell movement speed - - - - - - - - - - - - - - - - - - increased cell migration speed - CMPO:0000236 - cell moves faster - A phenotype observation at the level of the cell movement where the cell moves faster than normal/wild type. - - - - - - - - - increased cell movement distance - - CMPO:0000237 - A phenotype observation at the level of the cell movement where the distance travelled by the cell is increased. The distance is measured as the euclidean distance between start and end point of the cell trajectory. - increased cell migration distance - cells cover a longer distance - - - - - - - - - decreased cell movement phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation at the level of the cell movement where cell movement is decreased - CMPO:0000238 - decreased cell movement - - - - - - - - - decreased cell movement distance - - cells cover a shorter distance - CMPO:0000239 - A phenotype observation at the level of the cell movement where the distance travelled by the cell is decreased. The distance is measured as the euclidean distance between start and end point of the cell trajectory. - - - - - - - - - decreased cell movement speed - - - - - - - - - - - - - - - - - - CMPO:0000240 - A phenotype observation at the level of the cell movement where the cell moves slower than normal/wild type. - cell moves slower - - - - - - - - - proliferating cells - - - - - - - - - - - - - - - - - - high cell number in population - increased proliferation - CMPO:0000241 - increased number of cells in population phenotype - - - - - - - - - actin-mediated cell contraction phenotype - - - - - - - - - - - - - - - - - - CMPO:0000243 - cell contraction - A phenotype of a cell contraction caused by an actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body. - actin-mediated cell contraction - - - - - - - - - cell component movement phenotype - - - - - - - - - - - - - - - - - - A phenotype where the directed, self-propelled movement of a cellular component without the involvement of an external agent such as a transporter or a pore is observed - CMPO:0000244 - cell component movement - - - - - - - - - cell secretion phenotype - - - - - - - - - - - - - - - - - - A phenotype observation of the controlled release of a substance by a cell. - CMPO:0000245 - cell secretion phenotype - - - - - - - - - increased rate of protein secretion - - - - - - - - - - - - - - - - - - enhanced protein secretion - PMID:22660414 - CMPO:0000246 - A phenotype observation where the rate of release of proteins from a cell is increased - - - - - - - - - decreased rate of protein secretion - - - - - - - - - - - - - - - - - - inhibition of protein secretion - A phenotype observation where the rate of release of proteins from a cell is decreased - CMPO:0000247 - - - - - - - - - nuclear morphology phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - CMPO:0000249 - A phenotype observation at the level of the nucleus relating to the nuclear morphology - nuclear morphology - - - - - - - - - golgi morphology phenotype - - - - - - - - - - - - - - - - - - - CMPO:0000250 - A phenotype observation at the level of the golgi relating to the golgi's morphology - golgi morphology - - - - - - - - - cilium phenotype - - - - - - - - - - - - - - - - - - A phenotype observation at the level of the cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. - CMPO:0000251 - cilium phenotype - - - - - - - - - cilium morphology phenotype - - - - - - - - - - - - - - - - - - - A phenotype observation at the level of a cilium relating to the components shape, size or structure - CMPO:0000252 - cilium morphology - - - - - - - - - single cell phenotype - - - - - - - - - - - - - - - - - - CMPO:0000258 - A quality that inherers in a single or whole cell. - single cell phenotype - - - - - - - - - cellular component phenotype - - - - - - - - - - - - - - - - - - A quality that inheres in the cellular component of a cell - CMPO:0000259 - cellular component phenotype - - - - - - - - - geometric cell phenotype - - CMPO:0000261 - A phenotype observation at the level of the cell shape where the cell has a geometric shape with straight edges - PMID:21893601 - geometric cell - request geometric shape in pato - - - - - - - - - apoptotic DNA - - - - - - - - - - - - - - - - - - CMPO:0000262 - Fragmented and condensed DNA during or following apoptosis - apoptotic DNA - - - - - - - - - more cells in M phase - - - - - - - - - - - - - - - - - - CMPO:0000263 - Increased occurrence of mitotic cells - increased number of mitotic cells - increased occurrence of mitosis - - - - - - - - - fewer cells in M phase - - - - - - - - - - - - - - - - - - less cells in M phase - decreased occurrence of mitosis - decreased number of cell in mitosis - decreased occurrence of mitotic cells in population - CMPO:0000264 - decreased number of mitotic cells - - - - - - - - - M phase mitotic phenotype - - - - - - - - - - - - - - - - - - - CMPO:0000265 - A phenotype observation at the level of the M phase of the mitotic cell cycle - M phase mitotic phenotype - - - - - - - - - asymmetric lamellipodia phenotype - - - - - - - - - - - - - - - - - - - PMID:21893601 - A phenotype observation where more lamellipoda is localised to one side of the cell with respect to the other - asymmetric lamellae - CMPO:0000266 - asymmetric lamellipodia - - - - - - - - - star shaped cell phenotype - - - - - - - - - - - - - - - - - - - PMID:21893601 - CMPO:0000267 - spiky cell - A phenotype observation at the level of the cell shape where the cell has a star-like or bristly shape - star shaped cell - - - - - - - - - spiny shaped cell phenotype - - - - - - - - - - - - - - - - - - - PMID:21893601 - CMPO:0000268 - A phenotype observation at the level of the cell shape where the cell has a star-like or bristly shape - spiny shaped cell - - - - - - - - - increased variability of cell size in population - - - - - - - - - - - - - - - - - - A population of cells where the cells exhibit a high variability of size - CMPO:0000269 - variable cell size - - - - - - - - - increased variability of cell shape in population - - - - - - - - - - - - - - - - - - - - - - - - - - variable cell shape - A population of cells where the cells exhibit a high variability of shape - CMPO:0000270 - - - - - - - - - cortical actin cytoskeleton phenotype - - - - - - - - - - - - - - - - - - A phenotype observation at the level of the cortical actin cytoskeleton, the portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane. - peripheral actin phenotype - CMPO:0000271 - cortical actin cytoskeleton phenotype - - - - - - - - - increased cortical actin cytoskeleton mass phenotype - - - - - - - - - - - - - - - - - - A phenotype observation at the level of the cortical actin cytoskeleton where the components mass has increased. - increased peripheral actin - PMID:21893601 - CMPO:0000272 - increased cortical actin cytoskeleton mass - - - - - - - - - decreased cortical actin cytoskeleton mass phenotype - - - - - - - - - - - - - - - - - - PMID:21893601 - CMPO:0000273 - A phenotype observation at the level of the cortical actin cytoskeleton where the components mass has decreased. - decreased cortical actin cytoskeleton mass - decreased peripheral actin - - - - - - - - - disorganised cortical actin cytoskeleton phenotype - - - - - - - - - - - - - - - - - - - PMID:21893601 - CMPO:0000274 - disorganised peripheral actin phenotype - A phenotype observation at the level of the cortical actin cytoskeleton where the component shows an irregular organization - disorganised cortical actin cytoskeleton - - - - - - - - - increased lamellipodia width phenotype - - - - - - - - - - - - - - - - - - - PMID:21893601 - increased width of lamellae - CMPO:0000276 - A phenotype observation at the level of a lamellipodia where the components width has increased. - increased lamellipodia width - - - - - - - - - decreased lamellipodia width phenotype - - - - - - - - - - - - - - - - - - - CMPO:0000277 - A phenotype observation at the level of a lamellipodia where the components width has decreased. - PMID:21893601 - decreased lamellipodia width - decreased width of lamellae - - - - - - - - - fan-shaped lamellipodia phenotype - - - - - - - - - - - - - - - - - - - CMPO:0000278 - A phenotype observation where the lamellipodia is shaped in the form of a fan. - PMID:21893601 - fan-shaped lamellipodia - motile lamellae - - - - - - - - - lamellipodium phenotype - - - - - - - - - - - - - - - - - - A phenotype observation at the level of a cell with an increased amount of lamellipodia. - CMPO:0000279 - lamellipodium phenotype - - - - - - - - - cell projection phenotype - - - - - - - - - - - - - - - - - - A phenotype observation at the level of a cellular component relating to a prolongation or process extending from a cell, e.g. a cilium, lamellipodium or axon. - CMPO:0000280 - cell projection phenotype - - - - - - - - - filopodium phenotype - - - - - - - - - - - - - - - - - - A phenotype observation at the level of the filopodium; a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast. - CMPO:0000281 - filopodium - - - - - - - - - layered cells in population - - PMID:21893601 - CMPO:0000282 - layered cells - Cells not stopping at confluence and growing on top of each other in layers - - - - - - - - - actin cytoskeleton phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - CMPO:0000283 - A phenotype observation at the level of the actin cytoskeleton, the part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. - actin cytoskeleton - - - - - - - - - increased actin cytoskeleton mass phenotype - - - - - - - - - - - - - - - - - - CMPO:0000284 - A phenotype observation at the level of a actin cytoskeleton where the components mass has increased - PMID:21893601 - increased actin cytoskeleton mass - - - - - - - - - decreased actin cytoskeleton mass phenotype - - - - - - - - - - - - - - - - - - PMID:21893601 - CMPO:0000285 - A phenotype observation at the level of a actin cytoskeleton where the components mass has decreased. - decreased actin cytoskeleton mass - - - - - - - - - aggregated microtubules phenotype - - - - - - - - - - - - - - - - - - - PMID:21893601 - A phenotype observation where microtubules form clump-like structures as opposed to filaments - CMPO:0000286 - aggregated microtubules - microtubule clumps - - - - - - - - - microtubules nuclear bracket phenotype - - - - - - - - - - - - - - - - - - - - - - - PMID:21893601 - CMPO:0000287 - A phenotype observation where the microtubules form two crescent shaped brackets around the nucleus - microtubules nuclear bracket - - - - - - - - - microtubules nuclear ring phenotype - - - - - - - - - - - - - - - - - - - - - - - CMPO:0000288 - PMID:21893601 - microtubule nuclear ring - A phenotype observation where the microtubules form a ring around the nucleus - microtubules nuclear ring - - - - - - - - - increased amount of stress fibers phenotype - - - - - - - - - - - - - - - - - - - - - - A phenotype observation at the level of any stress fibers where the components number has increased. - CMPO:0000289 - increased amount of stress fibers - more actin stress fibers - pmid:21893601 - - - - - - - - - punctate actin foci phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - puncta actin filament phenotype - A phenotype observation where actin is observed as small patches or spots all over the cell - CMPO:0000290 - punctate actin foci - - - - - - - - - increased amount of punctate actin foci phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - more actin puncta - CMPO:0000291 - PMID:21893601 - increased actin puncta - A phenotype observation where a cell has an increased amount of actin observed as small patches or spots all over the cell - increased amount of punctate actin foci - - - - - - - - - cell population layer phenotype - - http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20216 - A phenotype of a culture in which cells grow as a monolayer that is attached to the culture substrate. - CMPO:0000292 - cell layer phenotype - - - - - - - - - loss of cell monolayer - - loss of cell monolayer - Loss of sheet like monolayer leading to empty patches - CMPO:0000293 - lost cell monolayer - - - - - - - - - increased actin localised to the nucleus - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - CMPO:0000294 - increased nuclear actin - A phenotype observation where many actin filaments are observed in or around the nucleus - PMID: 21893601 - - - - - - - - - increased actin localised to the cytoplasm - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - PMID: 21893601 - CMPO:0000296 - increased cytoplasmic actin - A phenotype observation where many actin filaments are observed in the cytoplasm - - - - - - - - - increased amount of stress fibers located in the cell cortex phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Increased amount of actin stress fibers in the cortical area - more cortical actin stress fibers - A phenotype observation at the level of stress fibers localized to the cell cortex where the components number has increased. - CMPO:0000297 - increased amount of stress fibers located in the cell cortex - pmid:21893601 - - - - - - - - - increased amount of transverse stress fibers - - pmid:21893601 - CMPO:0000298 - Increased amount of actin stress fibers, forming transverse arcs located in the cell cortex - more transverse actin stress fibers - A phenotype observation at the level of stress fibers where the components number has increased and formed transverse arcs which are located in the cell cortex - - - - - - - - - increased amount of zig-zag stress fibers - - CMPO:0000299 - more zig-zag actin stress fibers - A phenotype observation at the level of stress fibers where the components number has increased and formed a zig zag pattern across the cell - Increased amount of actin stress fibers, with zig-zag pattern across the cell - pmid:21893601 - - - - - - - - - more multinucleate cells - - - - - - - - - - - - - - - - - - CMPO:0000300 - Increased cells that are multinucleated - - - - - - - - - no cells phenotype - - CMPO:0000301 - Absence of cells - PMID:21893601 - no cells - - - - - - - - - actin nuclear ring phenotype - - - - - - - - - - - - - - - - - - - - - - - nuclear actin ring - PMID:21893601 - A phenotype observation where the microtubules form a ring around the nucleus - CMPO:0000302 - actin nuclear ring - - - - - - - - - cell component morphology phenotype - - - - - - - - - - - - - - - - - - CMPO:0000303 - A phenotype observation at the level of a cellular component relating to the components shape, size or structure - cell component morphology - - - - - - - - - cell cycle arrested phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype of a cell where a particular process is arrested, or ends earlier in time than expected - CMPO:0000304 - cell cycle arrested - - - - - - - - - metaphase arrested phenotype - - - - - - - - - - - - - - - - - - - metaphase arrest - CMPO:0000305 - PMID:20360735 - A phenotype of a cell arrested in mitotic metaphase - metaphase arrested - - - - - - - - - delayed process phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype of a cell where a particular process is delayed - CMPO:0000306 - delayed process - - - - - - - - - metaphase delayed phenotype - - - - - - - - - - - - - - - - - - - metaphase delay - PMID:20360735 - CMPO:0000307 - A phenotype of a cell where mitotic metaphase is delayed - metaphase delayed - - - - - - - - - impaired cell migration - - - - - - - - - - - - - - - - - - - - - - abnormal cell migration - CMPO:0000309 - A phenotype where the cell migration is impaired - - - - - - - - - increased duration of cell migration process phenotype - - - - - - - - - - - - - - - - - - PMID:20360735 - A phenotype where the cell migration process occurs for longer, typically observed as a cell moving a further distance - CMPO:0000312 - increased duration of cell migration process - - - - - - - - - decreased duration of cell migration process phenotype - - - - - - - - - - - - - - - - - - CMPO:0000313 - A phenotype where the cell migration process duration is reduced, typically observed as a cell moving a shorter distance - decreased duration of cell migration process - - - - - - - - - exit from mitosis phenotype - - - - - - - - - - - - - - - - - - CMPO:0000314 - A phenotype observation at the level of the exit from mitosis - exit from mitosis - - - - - - - - - absence of cell process phenotype - - - - - - - - - - - - - - - - - - - - - - - cell physiology phenotype - A phenotype observation at the level of a cellular process where the cell process is absent - CMPO:0000315 - absence of cell process - - - - - - - - - abnormal cell growth phenotype - - - - - - - - - - - - - - - - - - - - - - CMPO:0000316 - A phenotype observation of the process in which the cell growth is abnormal - abnormal cell growth - - - - - - - - - cell growth arrested phenotype - - - - - - - - - - - - - - - - - - - CMPO:0000317 - A phenotype observation of the process in which the cell growth is arrested - cell growth arrested - - - - - - - - - mild decrease in rate of protein secretion - - - - - - - - - - - - - - - - - - - - - - PMID:22660414 - A phenotype observation where the rate of release of proteins from a cell is mildly decreased - CMPO:0000318 - mild inhibition of protein secretion - - - - - - - - - strong decrease in rate of protein secretion - - - - - - - - - - - - - - - - - - - - - - strong inhibition of protein secretion - PMID:22660414 - CMPO:0000319 - A phenotype observation where the rate of release of proteins from a cell is severly decreased - - - - - - - - - increased cell spreading phenotype - - - - - - - - - - - - - - - - - - CMPO:0000320 - A phenotype observation where there is an increased occurance of cell spreading - increased cell spreading - - - - - - - - - mild increase of cell spreading phenotype - - - - - - - - - - - - - - - - - - - - - - A phenotype observation where there is a mild increase of cell spreading - PMID:19667130 - CMPO:0000321 - moderate cell spreading - mild increase of cell spreading - - - - - - - - - strong increase of cell spreading phenotype - - - - - - - - - - - - - - - - - - - - - - A phenotype observation where there is a severe increase in cell spreading - CMPO:0000322 - extensive cell spreading - strong increase of cell spreading - - - - - - - - - decreased cell spreading phenotype - - - - - - - - - - - - - - - - - - poor cell spreading - A phenotype observation where there is a decreased occurance of cell spreading - CMPO:0000323 - PMID:19667130 - decreased cell spreading - - - - - - - - - absence of cell spreading phenotype - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation where cell spreading is absent - absence of cell spreading - no spreading cells - CMPO:0000324 - - - - - - - - - spread cell morphology phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - CMPO:0000325 - A phenotype observation where a cell shows a thin and large projected areas, with developed matrix adhesions at the cell periphery, as opposed to round cells with no or few adhesion sites - spread cell morphology - spreading cell shape - - - - - - - - - abnormal chromosome segregation phenotype - - - - - - - - - - - - - - - - - - - - - - segregation problems - CMPO:0000326 - abnormal chromosome segregation - lagging chromosomes - chromatin bridges - PMID:20360735 - A phenotype observation of the process in which the chromosome segregation is abnormal - multiple DNA masses - - - - - - - - - mitotic prophase phenotype - - - - - - - - - - - - - - - - - - - A phenotype observation at the level of the mitotic prophase of the cell cycle - CMPO:0000327 - mitotic prophase phenotype - - - - - - - - - increased duration of mitotic prophase phenotype - - - - - - - - - - - - - - - - - - A phenotype observation where the duration of the mitotic prophase of the cell cycle is increased - CMPO:0000328 - increased duration of mitotic prophase - - - - - - - - - decreased duration of mitotic prophase phenotype - - - - - - - - - - - - - - - - - - CMPO:0000329 - A phenotype observation where the duration of the mitotic prophase of the cell cycle is decreased - decreased duration of mitotic prophase - - - - - - - - - decreased frequency of negative regulation of NF-kappaB transcription factor activity phenotype - - - - - - - - - - - - - - - - - - A phenotype observation where the frequency of a process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB is decreased. - decreased frequency of negative regulation of NF-kappaB transcription factor activity - decreased number of oscillations; the amplitude of the first peak is comparable to control, although the duration may be increased; the time of the second and third peaks is delayed, due to greater interval times between termination and initiation of nuclear translocation responses - CMPO:0000330 - decreased NF-kB oscillation - PMID:23300644 - - - - - - - - - increased frequency of negative regulation of NF-kappaB transcription factor activity phenotype - - - - - - - - - - - - - - - - - - A phenotype observation where the frequency of a process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB is increased. - CMPO:0000331 - PMID:23300644 - increased NF-kB oscillation - increased frequency of negative regulation of NF-kappaB transcription factor activity - increased number of oscillations; the amplitude of the second and third peak is increased and nuclear translocation responses occur at increased intervals. - - - - - - - - - cytoplasmic sequestering of NF-kappaB phenotype - - - - - - - - - - - - - - - - - - - - increased number of oscillations; the amplitude of the second and third peak is increased and nuclear translocation responses occur at increased intervals. - PMID:23300644 - no NF-kB oscillation phenotype - A phenotype observation where the frequency of a process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB is increased. - CMPO:0000332 - cytoplasmic sequestering of NF-kappaB - - - - - - - - - abnormal release of cytoplasmic sequestered NF-kappaB phenotype - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation where the release of NF-kappaB from specific molecules in the cytoplasm to which it was bound, thereby allowing its translocation into the nucleus, is abnormal. - contains all cases that are significantly different from the rest, but don't share any clear commonalities. NF-kB oscillation patterns are not synchronized within a cell population, oscillation amplitude and frequency follow erratic patterns - different NF-kB oscillation phenotype - PMID:23300644 - CMPO:0000333 - abnormal release of cytoplasmic sequestered NF-kappaB - - - - - - - - - regulation of process phenotype - - - - - - - - - - - - - - - - - - CMPO:0000334 - A phenotype observation where any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. - regulation of process phenotype - - - - - - - - - bright nuclear body phenotype - - - - - - - - - - - - - - - - - - A phenotype obervation where the nuclear body's color brightness is relatively high. - pmid:22884692 - increased intensity of nuclear body - CMPO:0000335 - bright nuclear body - - - - - - - - - round focal adhesion - - - - - - - - - - - - - - - - - - CMPO:0000337 - A phenotype observation where the shape of the focal adhesion has every part of the surface or the circumference equidistant from the center. - - - - - - - - - mitosis arrested - - - - - - - - - - - - - - - - - - - CMPO:0000338 - A phenotype of a cell that is arrested at mitosis - PMID:20360735 - mitotic arrest - - - - - - - - - increased cell size in population - - - - - - - - - - - - - - - - - - - large cells - CMPO:0000340 - A population of cells where there is an increased number of large cells in the population - increased cell size in population - - - - - - - - - pyknotic nuclear phenotype - - CMPO:0000341 - A phenotype observation at the level of the nucleus underoging Pyknosis, or karyopyknosis, consisting of the irreversible condensation of chromatin in the nucleus of a cell undergoing necrosis or apoptosis. - pyknotic nucleus - pyknotic cell - - - - - - - - - prometaphase arrested phenotype - - - - - - - - - - - - - - - - - - - prometaphase arrest - CMPO:0000343 - A phenotype of a cell arrested in mitotic prometaphase - prometaphase arrested - - - - - - - - - prometaphase delayed phenotype - - - - - - - - - - - - - - - - - - - - A phenotype of a cell where mitotic prometaphase is delayed - CMPO:0000344 - prometaphase delay - prometaphase delayed - - - - - - - - - increased variability of nuclear shape in population - - - - - - - - - - - - - - - - - - - - - - - - - - CMPO:0000345 - A population of cells where the nuclei exhibit a high variability of shape - variable cell shape - - - - - - - - - decreased rate of intracellular protein transport phenotype - - - - - - - - - - - - - - - - - - A phenotype observation where the rate of intracellular protein transport is decreased - CMPO:0000346 - pmid:21795383 - decreased rate of intracellular protein transport - - - - - - - - - absence of mitotic metaphase process phenotype - - - - - - - - - - - - - - - - - - - - - - - A phenotype resulting in the absence of mitotic metaphase process - CMPO:0000347 - absence of mitotic metaphase - - - - - - - - - mitotic metaphase plate congression phenotype - - - - - - - - - - - - - - - - - - - metaphase alignment problem - CMPO:0000348 - A phenotype observation at the level of the cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis. - mitotic metaphase plate congression - - - - - - - - - increased substrate-dependent cell migration, cell extension phenotype - - - - - - - - - - - - - - - - - - CMPO:0000349 - A phenotype where an increased formation of a cell surface protrusion, such as a lamellipodium or filopodium, at the leading edge of a migrating cell is observed. - increased protrusive activity - increased substrate-dependent cell migration, cell extension - - - - - - - - - increased substrate-dependent cell migration phenotype - - - - - - - - - - - - - - - - - - CMPO:0000350 - increased directional cell migration - A phenotype where an increased occurrence of the orderly movement of a cell from one site to another along a substrate such as the extracellular matrix is observed. - increased substrate-dependent cell migration - - - - - - - - - increased microtubule-based processes phenotype - - - - - - - - - - - - - - - - - - A phenotype where an increased occurance of any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins, is observed. - increased microtubule-based processes - microtubule processes - CMPO:0000351 - - - - - - - - - increased monopolar cell elongation phenotype - - - - - - - - - - - - - - - - - - - CMPO:0000353 - A phenotype observation of the process in which a cell increases in size due to polarized growth from one end of a cell. - increased monopolar cell elongation - increased polar cell elongation - - - - - - - - - decreased monopolar cell elongation phenotype - - - - - - - - - - - - - - - - - - - decreased polar cell elongation - CMPO:0000354 - A phenotype observation of the process in which a cell decreases in size due to polarized growth from one end of a cell. - decreased monopolar cell elongation - - - - - - - - - mild actin-mediated cell contraction phenotype - - - - - - - - - - - - - - - - - - - - - - A phenotype of a cell contraction caused by an actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in mild contraction of all or part of the cell body. - CMPO:0000355 - mild actin-mediated cell contraction - - - - - - - - - cell component localization phenotype - - - - - - - - - - - - - - - - - - cell component localization - A phenotype where any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location is observed - CMPO:0000356 - cell component localisation - - - - - - - - - polylobed nuclear phenotype - - - - - - - - - - - - - - - - - - CMPO:0000357 - acinus nuclear phenotype - A phenotype observation where the shape of the nucleus resembles a many-lobed berry, such as a raspberry. - - - - - - - - - increased rate of DNA amplification - - - - - - - - - - - - - - - - - - A phenotype of a cell where the rate of DNA amplification is increased - CMPO:0000358 - increased rate of DNA amplification - - - - - - - - - increased amount of DNA - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - CMPO:0000359 - A phenotype observation where a cell has an increased amount of DNA - increased amount of DNA - - - - - - - - - centriole replication phenotype - - - - - - - - - - - - - - - - - - CMPO:0000360 - A phenotype of a cell in which the biological process resulting in a doubling of the number of centrioles in the cell is affected - pmid:18620859 - centriole duplication phenotype - centriole replication - - - - - - - - - increased centriole replication phenotype - - - - - - - - - - - - - - - - - - - centriole amplification phenotype - CMPO:0000361 - A phenotype of a cell in which the biological process resulting in a the number of centrioles is increased - increased centriole replication - - - - - - - - - decreased centriole replication phenotype - - - - - - - - - - - - - - - - - - CMPO:0000362 - A phenotype of a cell in which the biological process resulting in a the number of centrioles is decreased - centriole underduplication phenotype - decreased centriole replication - - - - - - - - - protein localization to cellular component phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - CMPO:0000363 - - - - - - - - - s-shaped cell phenotype - - - - - - - - - - - - - - - - - - - A phenotype observation at the level of the cell shape where the cell is in a shape that consists of two curves in opposite directions. - kinky cell - S-shaped cell - FYPO:0002760 - CMPO:0000364 - z-shaped cell - sigmoid cell - PMID: 25373780 - kinked cell - - - - - - - - - curved cell phenotype - - - - - - - - - - - - - - - - - - - CMPO:0000365 - PMID: 25373780 - A phenotype observation at the level of the cell shape where the cell is curved along the long axis. - FYPO:0002112 - Curved cell - - - - - - - - - pear-shaped cell phenotype - - - - - - - - - - - - - - - - - - - - - PMID: 25373780 - CMPO:0000366 - skittle-shaped cell - FYPO:0002903 - A phenotype observation at the level of the cell shape where the shape is in the form of a pear. One end is rounded, while the other is rod-shaped. - Pear-shaped cell - - - - - - - - - stubby cell phenotype - - - - - - - - - - - - - - - - - - - CMPO:0000367 - wide cell - FYPO:0002106 - A phenotype observation at the level of the cell shape where the shape is stubby. The cell diameter is larger than normal and the cell length is shorter than normal. - PMID: 25373780 - Stubby cell - - - - - - - - - microtubule cytoskeleton morphology phenotype - - - - - - - - - - - - - - - - - - - CMPO:0000368 - A phenotype observation at the level of the microtubule cytoskeleton relating to the components shape, size or structure - microtubule cytoskeleton morphology - - - - - - - - - microtubule cytoskeleton morphology during mitotic interphase - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A physical cellular phenotype in interphase of the mitotic cell cycle where the the size, shape, or structure of the microtubule cytoskeleton is observed. - FYPO:0003625 - CMPO:0000368 - PMID: 25373780 - microtubule cytoskeleton morphology during mitotic interphase - - - - - - - - - elongated cytoplasmic microtubules phenotype - - - - - - - - - - - - - - - - - - - FYPO:0000233 - elongated cytoplasmic microtubules - A physical cellular phenotype which cells form cytoplasmic microtubules that are longer than normal. - long cytoplasmic microtubules - elongated cytoplasmic microtubules - PMID: 25373780 - CMPO:0000370 - - - - - - - - - shortened cytoplasmic microtubules phenotype - - - - - - - - - - - - - - - - - - - CMPO:0000371 - FYPO:0002401 - shortened cytoplasmic microtubules - PMID: 25373780 - elongated cytoplasmic microtubules - A physical cellular phenotype which cells form cytoplasmic microtubules that are shorter than normal. - - - - - - - - - increased number of microtubule bundle phenotype - - - - - - - - - - - - - - - - - - - - - - extra microtubule bundles - PMID: 25373780 - increased microtubule bundling - A phenotype observation at the level of microtubule bundle where the components number has increased. - increased number of microtubule bundle - more microtubule bundles - FYPO:0003595 - increased level of MT bundles - CMPO:0000372 - - - - - - - - - microtubule morphology phenotype - - - - - - - - - - - - - - - - - - - A phenotype observation at the level of the microtubule relating to the components shape, size or structure - PMID: 25373780 - CMPO:0000373 - microtubule morphology - - - - - - - - - microtubule morphology during interphase phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - PMID: 25373780 - CMPO:0000374 - A phenotype observation at the level of the microtubule relating to the components shape, size or structure observed in mitotic interphase. - microtubule morphology during interphase - - - - - - - - - more cells with interphase microtubule phenotype - - - - - - - - - - - - - - - - - - PMID: 25373780 - An increased number of interphase microtubule phenotype in population. - more cells with interphase microtubule - CMPO:0000375 - - - - - - - - - microtubule spindle morphology phenotype - - - - - - - - - - - - - - - - - - CMPO:0000376 - A phenotype observation at the level of the microtubule spindle relating to the components shape, size or structure - PMID: 25373780 - microtubule spindle morphology - - - - - - - - - microtubule spindle morphology during metaphase phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - CMPO:0000377 - A phenotype observation at the level of the microtubule spindle relating to the components shape, size or structure observed during metaphase. - PMID: 25373780 - microtubule spindle morphology during metaphase - - - - - - - - - more cells with metaphase microtubule spindles phenotype - - - - - - - - - - - - - - - - - - more cells with metaphase microtubule spindles - CMPO:0000378 - PMID: 25373780 - SP increased - An increased number of metaphase microtubule spindles in population. - - - - - - - - - linear microtubule morphology phenotype - - A phenotype observation at the level of the microtubule where the microtuble are narrow, with the two opposite margins parallel. - CMPO:0000379 - PMID: 25373780 - linear microtubule morphology - - - - - - - - - cell component organisation phenotype - - - - - - - - - - - - - - - - - - - - - - - CMPO:0000380 - A phenotype obesrvation relating to the orgnaistation of cellular componets in the cell. - cell component organisation - - - - - - - - - microtubule organisation phenotype - - - - - - - - - - - - - - - - - - - - - - CMPO:0000380 - A phenotype observation relating to the organisation of cellular components in the cell. - cell component organisation - - - - - - - - - microtubule array phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation relating to the organisation of microtubules in the cell, where the microtubules are organized into an array. - CMPO:0000382 - microtubule array - PMID: 25373780 - - - - - - - - - more cells with interphase microtubule arrays phenotype - - - - - - - - - - - - - - - - - - - - - - - An increased number of interphase microtubule array phenotype in population. - more cells with interphase microtubule arrays - PMID: 25373780 - CMPO:0000383 - IP increased - - - - - - - - - interphase phenotype - - - - - - - - - - - - - - - - - - A phenotype observation at the level of interphase of the cell cycle - CMPO:0000384 - interphase phenotype - - - - - - - - - mitotic interphase phenotype - - - - - - - - - - - - - - - - - - - A phenotype observation at the level of interphase of the cell cycle - CMPO:0000384 - mitotic interphase phenotype - - - - - - - - - anaphase phenotype - - - - - - - - - - - - - - - - - - A phenotype observation at the level of anaphase of the cell cycle - CMPO:0000386 - anaphase phenotype - - - - - - - - - fewer cells with metaphase microtubule spindles phenotype - - - - - - - - - - - - - - - - - - CMPO:0000387 - fewer cells with metaphase microtubule spindles - SP reduced - PMID: 25373780 - A decreased number of metaphase microtubule spindles in population. - - - - - - - - - fewer cells with interphase microtubule arrays phenotype - - - - - - - - - - - - - - - - - - - - - - - PMID: 25373780 - IP reduced - CMPO:0000388 - A decreased number of interphase microtubule array phenotypes in population. - fewer cells with interphase microtubule arrays - - - - - - - - - protein localized in golgi phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation in which a protein is observed to be localized within the Golgi apparatus. - PMID: 23509072 - protein localised in Golgi - protein localised in Golgi apparatus - protein localized to Golgi - protein localized to Golgi apparatus - CMPO:0000390 - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in Golgi - - - - - PMID: 23509072 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in Golgi apparatus - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localized to Golgi - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localized to Golgi apparatus - - - - - A phenotype observation in which a protein is observed to be localized within the Golgi apparatus. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - protein localized in bud neck phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation in which a protein is observed to be localized within a cellular bud neck. - PMID: 23509072 - protein localised in bud neck - protein localized in cellular bud neck - protein localized to bud neck - CMPO:0000391 - - - - A phenotype observation in which a protein is observed to be localized within a cellular bud neck. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in bud neck - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localized in cellular bud neck - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - PMID: 23509072 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localized to bud neck - - - - - - - - - - protein localized in cell periphery phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation in which a protein is observed to be localized within the cell periphery. - PMID: 23509072 - protein localised in cell periphery - protein localized to cell periphery - CMPO:0000392 - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in cell periphery - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localized to cell periphery - - - - - PMID: 23509072 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - A phenotype observation in which a protein is observed to be localized within the cell periphery. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - protein localized in cytosol phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation in which a protein is observed to be localized within the cytosol. - PMID: 23509072 - protein localised in cytosol - protein localized to cytosol - CMPO:0000393 - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in cytosol - - - - - A phenotype observation in which a protein is observed to be localized within the cytosol. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - PMID: 23509072 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localized to cytosol - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - protein localized in endoplasmic reticulum phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation in which a protein is observed to be localized within the endoplasmic reticulum. - PMID: 23509072 - protein localised in endoplasmic reticulum - protein localized to endoplasmic reticulum - CMPO:0000394 - - - - PMID: 23509072 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localized to endoplasmic reticulum - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in endoplasmic reticulum - - - - - A phenotype observation in which a protein is observed to be localized within the endoplasmic reticulum. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - protein localized in mitochondrion phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation in which a protein is observed to be localized within a mitochondrion. - PMID: 23509072 - protein localised in mitochondria - protein localised in mitochondrion - protein localized to mitochonria - protein localized to mitochonrion - CMPO:0000395 - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in mitochondria - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localized to mitochonrion - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localized to mitochonria - - - - - A phenotype observation in which a protein is observed to be localized within a mitochondrion. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in mitochondrion - - - - - PMID: 23509072 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - protein localized in nuclear periphery phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation in which a protein is observed to be localized within the nuclear periphery. - PMID: 23509072 - protein localised in nuclear periphery - protein localized to nuclear periphery - CMPO:0000396 - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in nuclear periphery - - - - - PMID: 23509072 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localized to nuclear periphery - - - - - A phenotype observation in which a protein is observed to be localized within the nuclear periphery. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - protein localized in nucleolus phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation in which a protein is observed to be localized within the nucleolus. - PMID: 23509072 - protein localised in nucleolus - protein localized to nucleolus - CMPO:0000397 - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in nucleolus - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localized to nucleolus - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - PMID: 23509072 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - A phenotype observation in which a protein is observed to be localized within the nucleolus. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - protein localized in nucleus phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation in which a protein is observed to be localized within the nucleus. - PMID: 23509072 - protein localised in nucleus - protein localized to nucleus - CMPO:0000398 - - - - PMID: 23509072 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localized to nucleus - - - - - A phenotype observation in which a protein is observed to be localized within the nucleus. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in nucleus - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - protein localized in peroxisome phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation in which a protein is observed to be localized within a peroxisome. - PMID: 23509072 - protein localised in peroxisome - protein localized to peroxisome - CMPO:0000399 - - - - PMID: 23509072 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - A phenotype observation in which a protein is observed to be localized within a peroxisome. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in peroxisome - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localized to peroxisome - - - - - - - - - - protein localized in punctate foci phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation in which a protein is observed to be localized within punctate foci - PMID: 23509072 - protein localised in punctate foci - protein localized to punctate foci - CMPO:0000400 - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in punctate foci - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localized to punctate foci - - - - - A phenotype observation in which a protein is observed to be localized within punctate foci - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - PMID: 23509072 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - protein localized in vacuole phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation in which a protein is observed to be localized within a vacuole. - PMID: 23509072 - protein localised in vacuole - protein localized to vacuole - CMPO:0000401 - - - - A phenotype observation in which a protein is observed to be localized within a vacuole. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localized to vacuole - - - - - PMID: 23509072 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in vacuole - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - protein localized in vacuolar membrane phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation in which a protein is observed to be localized within a vacuolar membrane. - PMID: 23509072 - protein localised in vacuolar membrane - protein localized to vacuolar membrane - CMPO:0000402 - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in vacuolar membrane - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation in which a protein is observed to be localized within a vacuolar membrane. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - PMID: 23509072 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localized to vacuolar membrane - - - - - - - - - - protein localized to nuclear body - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation in which a protein is observed to be localized within the nuclear body. - protein localised in nuclear body - protein localized to nuclear body - CMPO:0000403 - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localized to nuclear body - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in nuclear body - - - - - A phenotype observation in which a protein is observed to be localized within the nuclear body. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - protein localized in Cajal body phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation in which a protein is observed to be localized within a Cajal body. - PubMed ID:24127217 - protein localised in Cajal body phenotype - CMPO:0000404 - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation in which a protein is observed to be localized within a Cajal body. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in Cajal body phenotype - - - - - PubMed ID:24127217 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - protein localized in nuclear speckle phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation in which a protein is observed to be localized within a nuclear speckle. - PubMed ID:24127217 - protein localised in nuclear speckle phenotype - CMPO:0000405 - - - - A phenotype observation in which a protein is observed to be localized within a nuclear speckle. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - PubMed ID:24127217 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in nuclear speckle phenotype - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - protein localized in paraspeckle phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation in which a protein is observed to be localized within a paraspeckle. - PubMed ID:24127217 - protein localised in paraspeckle phenotype - CMPO:0000406 - - - - PubMed ID:24127217 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in paraspeckle phenotype - - - - - A phenotype observation in which a protein is observed to be localized within a paraspeckle. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - protein localized in PML body phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation in which a protein is observed to be localized within a PML body. - PubMed ID:24127217 - protein localised in PML body phenotype - protein localised in Promyelocytic Leukemia nuclear body phenotype - protein localized in Promyelocytic Leukemia nuclear body phenotype - CMPO:0000407 - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in Promyelocytic Leukemia nuclear body phenotype - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - PubMed ID:24127217 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in PML body phenotype - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localized in Promyelocytic Leukemia nuclear body phenotype - - - - - A phenotype observation in which a protein is observed to be localized within a PML body. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - protein localized in polycomb body phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation in which a protein is observed to be localized within a polycomb body. - PubMed ID:24127217 - protein localised in PcG body phenotype - protein localized in PcG body phenotype - protein localized in polycomb body phenotype - CMPO:0000408 - - - - PubMed ID:24127217 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation in which a protein is observed to be localized within a polycomb body. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localized in polycomb body phenotype - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localized in PcG body phenotype - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in PcG body phenotype - - - - - - - - - - protein localized in Sam68 nuclear body phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation in which a protein is observed to be localized within a Sam68 nuclear body. - PubMed ID:24127217 - protein localised in Sam68 nuclear body phenotype - CMPO:0000409 - - - PubMed ID:24127217 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - A phenotype observation in which a protein is observed to be localized within a Sam68 nuclear body. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in Sam68 nuclear body phenotype - - - - - - - - - - fewer cells with G1 phase microtubule arrays phenotype - - - - - - - - - - - - - - - - - - - - - - - A decreased number of post-anaphase or G1 phase microtubule arrays in population phenotype - PAA decreased - PMID: 25373780 - fewer cells with post-anaphase microtubule arrays - CMPO:0000410 - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - - - - - - - - - - - - - - - - PMID: 25373780 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - A decreased number of post-anaphase or G1 phase microtubule arrays in population phenotype - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - fewer cells with post-anaphase microtubule arrays - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - PAA decreased - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - fewer cells with S phase microtubule arrays phenotype - - - - - - - - - - - - - - - - - - - - - - - A decreased number of post-mitotic interphase or S phase microtubule arrays in population phenotype - IP2 decreased - PMID: 25373780 - fewer cells with post-mitotic interphase microtubule arrays - CMPO:0000411 - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - - - - - - - - - - - - - - - - IP2 decreased - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - fewer cells with post-mitotic interphase microtubule arrays - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - PMID: 25373780 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - A decreased number of post-mitotic interphase or S phase microtubule arrays in population phenotype - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - more cells with G1 phase microtubule arrays phenotype - - - - - - - - - - - - - - - - - - - - - - - An increased number of post-anaphase or G1 phase microtubule arrays in population phenotype - PAA increased - PMID: 25373780 - more cells with post-anaphase microtubule arrays - CMPO:0000412 - - - - PAA increased - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - more cells with post-anaphase microtubule arrays - - - - - PMID: 25373780 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - An increased number of post-anaphase or G1 phase microtubule arrays in population phenotype - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - more cells with S phase microtubule arrays phenotype - - - - - - - - - - - - - - - - - - - - - - - An increased number of post-mitotic interphase or S phase microtubule arrays in population phenotype - IP2 increased - PMID: 25373780 - more cells with post-mitotic interphase microtubule arrays - CMPO:0000413 - - - - PMID: 25373780 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - more cells with post-mitotic interphase microtubule arrays - - - - - IP2 increased - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - - - - - - - - - - - - - - - - An increased number of post-mitotic interphase or S phase microtubule arrays in population phenotype - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - cell response to stress phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation of respone to stress process within a cell. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). - CMPO:0000414 - cell response to stress - - - - - - - - - cell response to DNA damage phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - DNA damage - A phenotype observation of a process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. - CMPO:0000415 - cell response to DNA damage - - - - - - - - - fewer aggregated cells in population phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - CMPO:0000416 - fewer aggregated cells in population - PMID:24446484 - defective cell-cell aggregation - The population has a decreased number of cells forming cell-cell aggregates. - - - - - - - - - lack of protein in cell component localization phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation in which a protein is absent or decreased from the expected localisation of protein localisation process - PMID: 23547032 - protein absent from localisation to cellular component - example 'the smt3allR mutant does not show localization at the bud neck' - CMPO:0000417 - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein absent from localisation to cellular component - - - - - PMID: 23547032 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - A phenotype observation in which a protein is absent or decreased from the expected localisation of protein localisation process - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - response to stimulus phenotype - - - - - - - - - - - - - - - - - - A phenotype observation at the level of a response to stimulus process - CMPO:0000419 - - - - - - - - - response to chemical phenotype - - - - - - - - - - - - - - - - - - CMPO:0000420 - A phenotype observation at the level of a response to stimulus process - - - - - - - - - cellular response to chemical stimulus phenotype - - - - - - - - - - - - - - - - - - CMPO:0000421 - A phenotype observation at the level of a response to stimulus process - - - - - - - - - telophase phenotype - - - - - - - - - - - - - - - - - - CMPO:0000422 - A phenotype observation at the level of telophase of the cell cycle - telophase phenotype - - - - - - - - - mitotic telophase phenotype - - - - - - - - - - - - - - - - - - - A phenotype observation at the level of mitotic telophase of the cell cycle - CMPO:0000423 - telophase phenotype - - - - - - - - - telophase arrested phenotype - - - - - - - - - - - - - - - - - - - CMPO:0000424 - A phenotype of a cell where the mitotic telophase process is arrested, or ends earlier in time than expected - telophase arrested - - - - - - - - - protein localized in centrosome phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation in which a protein is observed to be localized within a centrosome. - PMID:23086237 - protein localisation in centrosome - protein localised in centrosome - protein localised to centrosome - protein localization in centrosome - CMPO:0000425 - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised to centrosome - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localization in centrosome - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localisation in centrosome - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in centrosome - - - - - A phenotype observation in which a protein is observed to be localized within a centrosome. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - PMID:23086237 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - protein localized in nuclear pore phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation in which a protein is observed to be localized within a nuclear pore. - PMID:23845946 - protein localisation in nuclear pore - protein localised in nuclear pore - protein localised to nuclear pore - protein localization in nuclear pore - CMPO:0000426 - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised to nuclear pore - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - PMID:23845946 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localisation in nuclear pore - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in nuclear pore - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localization in nuclear pore - - - - - A phenotype observation in which a protein is observed to be localized within a nuclear pore. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - kinetochore phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - CMPO:0000427 - A collection of qualities that inhere in any constituent part of the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. - kinetochore phenotype - - - - - - - - - fan-shaped cell phenotype - - - - - - - - - - - - - - - - - - - A phenotype observation at the level of the cell shape where the cell is fan-shaped - CMPO:0000428 - fan-shaped cell - - - - - - - - - cell polypeptide phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - cell protein phenotype - CMPO:0000429 - A phenotype observation at the level of the cell protein - cell protein phenotype - - - - - - - - - altered level of substance in cell - - - - - - - - - - - - - - - - - - - - - - A cell phenotype in which the amount of a specific substance measured in a cell differs from normal. - CMPO:0000430 - FYPO:0000989 - PomBase:mah - altered level of substance in cell - - - - - - - - - altered level of polypetide in cell - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A cell phenotype in which the amount of polypetide measured in a cell differs from normal. - CMPO:0000431 - altered level of polypeptide in cell - - - - - - - - - altered level of polypetide in cell nucleus - - - - - - - - - - - - - - - - - - - - - - - CMPO:0000432 - A cell phenotype in which the amount of polypetide measured in a cell nucleus differs from normal. - altered level of protein in cell nucleus - altered level of substance in cell nucleus - - - - - - - - - increased level of polypetide in cell nucleus - - - - - - - - - - - - - - - - - - - - - - A cell phenotype in which the amount of polypetide measured in a cell nucleus increases from normal. - increased level of protein in cell nucleus - CMPO:0000433 - incressed level of polypetide in cell nucleus - - - - - - - - - decreased level of polypetide in cell nucleus - - - - - - - - - - - - - - - - - - - - - - decreased level of protein in cell nucleus - CMPO:0000434 - A cell phenotype in which the amount of polypetide measured in a cell nucleus descreases from normal. - descreased level of polypetide in cell nucleus - - - - - - - - - negative regulation of protein import into nucleus phenotype - - - - - - - - - - - - - - - - - - CMPO:0000435 - A phenotype observation where any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus. - regulation of process phenotype - - - - - - - - - positive regulation of protein import into nucleus phenotype - - - - - - - - - - - - - - - - - - A phenotype observation where any process that starts or increases the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus. - CMPO:0000436 - positive regulation of protein import into nucleus - - - - - - - - - abnormal mitotic cell cycle phase phenotype - - - - - - - - - - - - - - - - - - - - - - - CMPO:0000437 - A phenotype where the mitotic cell cycle phase is abnormal - abnormal mitotic cell cycle phase - - - - - - - - - abnormal microtubule cytoskeleton morphology during mitotic interphase - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - CMPO:0000438 - FYPO:0003625 - PMID: 25373780 - A physical cellular phenotype in interphase of the mitotic cell cycle where the the size, shape, or structure of the microtubule cytoskeleton is abnormal. - abnormal microtubule cytoskeleton morphology during mitotic interphase - - - - - - - - - absence of protein localized in bud neck phenotype - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation in which a protein is not localized within a cellular bud neck. - CMPO:0000439 - - - - A phenotype observation in which a protein is not localized within a cellular bud neck. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - protein localized in actin filament phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation in which a protein is observed to be localized within an actin filament. - PubMed: 22361696 - protein localised in actin filament phenotype - CMPO:0000440 - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - PubMed: 22361696 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - A phenotype observation in which a protein is observed to be localized within an actin filament. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in actin filament phenotype - - - - - - - - - - protein localized in intermediate filament phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation in which a protein is observed to be localized within an intermediate filament. - PubMed: 22361696 - protein localised in intermediate filament phenotype - CMPO:0000441 - - - - PubMed: 22361696 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - A phenotype observation in which a protein is observed to be localized within an intermediate filament. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in intermediate filament phenotype - - - - - - - - - - protein localized in microtubule phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation in which a protein is observed to be localized within a microtubule. - PubMed: 22361696 - protein localised in microtubule phenotype - CMPO:0000442 - - - - A phenotype observation in which a protein is observed to be localized within a microtubule. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in microtubule phenotype - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - PubMed: 22361696 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - protein localized in nuclear membrane phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation in which a protein is observed to be localized the nuclear membrane. - PubMed: 22361696 - protein localised in nuclear membrane phenotype - protein localised in nuclear envelope phenotype - CMPO:0000443 - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation in which a protein is observed to be localized the nuclear membrane. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in nuclear membrane phenotype - - - - - PubMed: 22361696 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - protein localized in nucleoli fibrillar center phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation in which a protein is observed to be localized within the nucleolar fibrillar center. - PubMed: 22361696 - protein localised in nucleoli fibrillar center phenotype - CMPO:0000444 - - - - PubMed: 22361696 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in nucleoli fibrillar center phenotype - - - - - A phenotype observation in which a protein is observed to be localized within the nucleolar fibrillar center. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - protein localized in nucleoplasm phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation in which a protein is observed to be localized within the nucloplasm. - PubMed: 22361696 - protein localised in nucleoplasm phenotype - CMPO:0000445 - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - PubMed: 22361696 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in nucleoplasm phenotype - - - - - A phenotype observation in which a protein is observed to be localized within the nucloplasm. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - protein localized in plasma membrane phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation in which a protein is observed to be localized within the plasma membrane. - PubMed: 22361696 - protein localised in plasma membrane phenotype - CMPO:0000446 - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - PubMed: 22361696 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - A phenotype observation in which a protein is observed to be localized within the plasma membrane. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in plasma membrane phenotype - - - - - - - - - - protein localized in vesicle phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - A phenotype observation in which a protein is observed to be localized within a vesicle. - PubMed: 22361696 - protein localised in vesicle phenotype - CMPO:0000447 - - - - PubMed: 22361696 - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - A phenotype observation in which a protein is observed to be localized within a vesicle. - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - - - - - http://www.ebi.ac.uk/ontology/webulous#OPPL_pattern - protein localised in vesicle phenotype - - - - - - - - - - cell killing phenotype - - - - - - - - - - - - - - - - - - CMPO:0000448 - A phenotype where the the cells are killing either its own cells or those of another organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions. - cell killing phenotype - - - - - - - - - T cell mediated killing against a tumor cell phenotype - - - - - - - - - - - - - - - - - - - A phenotype where the the cells are killing either its own cells or those of another organism. The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. - CMPO:0000449 - 'T cell mediated cytotoxicity directed against tumor cell target phenotype - T cell mediated killing against a tumor cell phenotype - - - - - - - - - more aggregated cells in population phenotype - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The population has an increased number of cells forming cell-cell aggregates. - CMPO:0000450 - more aggregated cells in population phenotype - - - - - - - - - increased nucelar area phenotype - - - - - - - - - - - - - - - - - - CMPO:0000451 - A phenotype observation where the area of the nucelus has increased. - increased nucelar area phenotype - - - - - - - - - decreased nucelar area phenotype - - - - - - - - - - - - - - - - - - A phenotype observation where the area of the nucelus has decreased. - CMPO:0000452 - decreased nucelar area phenotype - - - - - - - - - decreased cell size in population - - - - - - - - - - - - - - - - - - - small cells - CMPO:0000453 - A population of cells where there is an increased number of small cells in the population - decreased cell size in population - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - 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- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - 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