diff --git a/requirements.txt b/requirements.txt
index 181cf6e..6114120 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -1,4 +1,4 @@
-pysam==0.19.1
+pysam==0.23.3
 biopython==1.77
 pytest==6.2.2
-pyyaml==5.4
\ No newline at end of file
+pyyaml==6.0.1
\ No newline at end of file