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Lecture 17: Immune repertoire sequencing and analysis

We will learn how to work with immune repertoire sequence data. Open lecture17.ipynb in VSCode. Make sure to select the kernel for R so that you can execute R code. You should have already set this up following the software installation instructions from last week.

This lecture will begin with a introduction to immune repertoire sequencing and analysis. We will then undertake a hands-on exercise using R and Bioconductor tools to analyze pre-processed immune repertoire data from two healthy individuals.

Learning Objectives

  • learn about immune repertoire sequencing
  • familiarize with immune repertoire data
  • work through an example analysis
    • visualize rearrangement statistics
    • evaluate repertoire overlap between individuals

Class materials

  • The lecture slides are available here

  • The Notebook which will be using for this lecture is available at lecture17.ipynb