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# Cyrius: WGS-based CYP2D6 genotyper
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Cyrius is a tool to genotype CYP2D6 from a whole-genome sequencing (WGS) BAM file. Cyrius uses a novel method to solve the problems caused by the high sequence similarity with the pseudogene paralog CYP2D7 and thus is able to detect all star alleles, particularly those that contain structural variants, accurately. Please refer to our [preprint](https://www.biorxiv.org/content/10.1101/2020.05.05.077966v2) for details about the method.
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Cyrius is a tool to genotype CYP2D6 from a whole-genome sequencing (WGS) BAM file. Cyrius uses a novel method to solve the problems caused by the high sequence similarity with the pseudogene paralog CYP2D7 and thus is able to detect all star alleles, particularly those that contain structural variants, accurately. Please refer to our [paper](https://www.nature.com/articles/s41397-020-00205-5) for details about the method.
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## Running the program
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