Fluvoxamine-Model.json

{
  "Version": 76,
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      },
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        }
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        {
          "Name": "CYP2D6",
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    {
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      },
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            {
              "Name": "Periportal",
              "Value": 1.0
            },
            {
              "Name": "Pericentral",
              "Value": 1.0
            },
            {
              "Name": "Lung",
              "Value": 0.00042695753798
            },
            {
              "Name": "SmallIntestine",
              "Value": 0.0727697702
            },
            {
              "Name": "Duodenum",
              "Value": 0.0727697702
            },
            {
              "Name": "UpperJejunum",
              "Value": 0.0727697702
            },
            {
              "Name": "LowerJejunum",
              "Value": 0.0727697702
            },
            {
              "Name": "UpperIleum",
              "Value": 0.0727697702
            },
            {
              "Name": "LowerIleum",
              "Value": 0.0727697702
            }
          ],
          "Ontogeny": {
            "Name": "CYP3A4"
          },
          "Parameters": [
            {
              "Name": "t1/2 (liver)",
              "Value": 36.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        }
      ]
    }
  ],
  "Compounds": [
    {
      "Name": "Fluvoxamine",
      "IsSmallMolecule": true,
      "Lipophilicity": [
        {
          "Name": "Measurement",
          "Parameters": [
            {
              "Name": "Lipophilicity",
              "Value": 3.5726507829,
              "Unit": "Log Units",
              "ValueOrigin": {
                "Source": "ParameterIdentification"
              }
            }
          ]
        }
      ],
      "FractionUnbound": [
        {
          "Name": "Measurement",
          "Species": "Human",
          "Parameters": [
            {
              "Name": "Fraction unbound (plasma, reference value)",
              "Value": 0.23,
              "ValueOrigin": {
                "Source": "Publication",
                "Description": "Claassen et al., Review of the animal pharmacology and pharmacokinetics of fluvoxamine. Br. J. Clin. Pharmacol. 15, 349S-355S (1983)."
              }
            }
          ]
        }
      ],
      "Solubility": [
        {
          "Name": "Measurement",
          "Parameters": [
            {
              "Name": "Solubility at reference pH",
              "Value": 14.66,
              "Unit": "mg/ml"
            },
            {
              "Name": "Reference pH",
              "Value": 7.0
            }
          ]
        }
      ],
      "IntestinalPermeability": [
        {
          "Name": "Fitted",
          "Parameters": [
            {
              "Name": "Specific intestinal permeability (transcellular)",
              "Value": 2.7380788903E-06,
              "Unit": "dm/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification"
              }
            }
          ]
        }
      ],
      "PkaTypes": [
        {
          "Type": "Base",
          "Pka": 9.4,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "Processes": [
        {
          "InternalName": "MetabolizationLiverMicrosomes_MM",
          "DataSource": "Fit",
          "Molecule": "CYP1A2",
          "Parameters": [
            {
              "Name": "In vitro Vmax for liver microsomes",
              "Value": 0.0,
              "Unit": "pmol/min/mg mic. protein"
            },
            {
              "Name": "Content of CYP proteins in liver microsomes",
              "Value": 45.0,
              "Unit": "pmol/mg mic. protein",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "Km",
              "Value": 0.0073460807948,
              "Unit": "µmol/l"
            },
            {
              "Name": "kcat",
              "Value": 0.0155447966,
              "Unit": "1/min",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        },
        {
          "InternalName": "rCYP450_MM",
          "DataSource": "Miura2007",
          "Molecule": "CYP2D6",
          "Parameters": [
            {
              "Name": "In vitro Vmax/recombinant enzyme",
              "Value": 0.69,
              "Unit": "pmol/min/pmol rec. enzyme"
            },
            {
              "Name": "Km",
              "Value": 76.3,
              "Unit": "µmol/l"
            },
            {
              "Name": "kcat",
              "Value": 110.5561921693,
              "Unit": "1/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification"
              }
            }
          ]
        },
        {
          "InternalName": "GlomerularFiltration",
          "DataSource": "4% Urine",
          "Species": "Human",
          "Parameters": [
            {
              "Name": "GFR fraction",
              "Value": 1.0
            }
          ]
        },
        {
          "InternalName": "MixedInhibition",
          "DataSource": "Karjalainen2008/Yao2001",
          "Molecule": "CYP1A2",
          "Parameters": [
            {
              "Name": "Ki_c",
              "Value": 10.0,
              "Unit": "nmol/l",
              "ValueOrigin": {
                "Source": "Publication",
                "Method": "InVitro",
                "Description": "Karjalainen et al. In vitro inhibition of CYP1A2 by model inhibitors, anti-inflammatory analgesics and female sex steroids: predictability of in vivo interactions. Basic Clin. Pharmacol. Toxicol. 103, 157–65 (2008) and Yao, C. et al. Fluvoxamine-theophylline interaction: gap between in vitro and in vivo inhibition constants toward cytochrome P4501A2. Clin. Pharmacol. Ther. 70, 415–24 (2001)"
              }
            },
            {
              "Name": "Ki_u",
              "Value": 10.0,
              "Unit": "nmol/l",
              "ValueOrigin": {
                "Source": "Publication",
                "Method": "InVitro",
                "Description": "Karjalainen et al. In vitro inhibition of CYP1A2 by model inhibitors, anti-inflammatory analgesics and female sex steroids: predictability of in vivo interactions. Basic Clin. Pharmacol. Toxicol. 103, 157–65 (2008) and Yao, C. et al. Fluvoxamine-theophylline interaction: gap between in vitro and in vivo inhibition constants toward cytochrome P4501A2. Clin. Pharmacol. Ther. 70, 415–24 (2001)"
              }
            }
          ]
        },
        {
          "InternalName": "CompetitiveInhibition",
          "DataSource": "Olesen2000/Yao2001",
          "Molecule": "CYP3A4",
          "Parameters": [
            {
              "Name": "Ki",
              "Value": 1.6,
              "Unit": "µmol/l",
              "ValueOrigin": {
                "Source": "Publication",
                "Method": "InVitro",
                "Description": "Olesen et al. Fluvoxamine-Clozapine drug interaction: inhibition in vitro of five cytochrome P450 isoforms involved in clozapine metabolism. J. Clin. Psychopharmacol. 20, 35–42 (2000) and Yao, C. et al. Fluvoxamine-theophylline interaction: gap between in vitro and in vivo inhibition constants toward cytochrome P4501A2. Clin. Pharmacol. Ther. 70, 415–24 (2001)"
              }
            }
          ]
        }
      ],
      "CalculationMethods": [
        "Cellular partition coefficient method - Schmitt",
        "Cellular permeability - PK-Sim Standard"
      ],
      "Parameters": [
        {
          "Name": "F",
          "Value": 3.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Name": "Molecular weight",
          "Value": 318.335,
          "Unit": "g/mol"
        }
      ]
    }
  ],
  "Formulations": [
    {
      "Name": "Solution",
      "FormulationType": "Formulation_Dissolved"
    }
  ],
  "Protocols": [
    {
      "Name": "Bahrami 2007, 100 mg SD",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 73.28,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "Chistensen 2002, 10 mg BID, EM",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 7.33,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "NumberOfRepetitions",
              "Value": 13.0,
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 12.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "Chistensen 2002, 25 mg BID, EM",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 18.32,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "NumberOfRepetitions",
              "Value": 13.0,
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 12.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "Chistensen 2002, 10 mg QD, PM",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 7.33,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "NumberOfRepetitions",
              "Value": 7.0,
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 24.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "Chistensen 2002, 25 mg QD, PM",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 18.32,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "NumberOfRepetitions",
              "Value": 7.0,
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 24.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "De Bree 1983, 100mg SD",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 73.28,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "de Vries 1992, 50 mg BID, 28 days",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 36.64,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "NumberOfRepetitions",
              "Value": 55.0,
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 12.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "de Vries 1993, 100 mg SD",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 73.28,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "de Vries 1993, 25 mg SD",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 18.32,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "de Vries 1993, 50 mg SD",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 36.64,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "Fleishaker 1994, 50 mg QD 3 days, 100 mg QD 7 days",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 36.64,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "NumberOfRepetitions",
              "Value": 3.0,
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 24.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        },
        {
          "Name": "Schema 2",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 73.28,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 72.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 7.0,
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 24.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "Fukasawa 2006, 50 mg SD",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 36.64,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "Jpanes Society 2015, 100 mg SD",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 73.28,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "Jpanes Society 2015, 200 mg SD",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 146.5,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "Jpanes Society 2015, 25 mg SD",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 18.32,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "Jpanes Society 2015, 30 mg SD, infusion 60min",
      "ApplicationType": "Intravenous",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 21.98,
          "Unit": "mg"
        },
        {
          "Name": "Infusion time",
          "Value": 60.0,
          "Unit": "min"
        }
      ]
    },
    {
      "Name": "Japanese Society 2015, 50 mg SD",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 36.64,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "Kunii 2005, 50 mg SD",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 36.64,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "Labellarte 2004, 150 mg BID, 7 days",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 109.92,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "NumberOfRepetitions",
              "Value": 29.0,
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 12.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "Orlando 2010, 50 mg SD",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 36.64,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "SENSITIVITY_300mgQD_10days",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 219.84,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "NumberOfRepetitions",
              "Value": 10.0,
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 24.0,
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          "Origin": "BaseGrid",
          "AuxiliaryType": "Undefined",
          "Date": "2018-02-28T14:19:27.4259805+01:00",
          "Source": "ALL_DATA.Sheet1.36.TIME"
        },
        "Values": [
          2.03,
          3.04,
          4.03,
          5.08,
          5.95,
          7.97000027,
          11.89,
          23.95,
          31.8900013
        ],
        "Dimension": "Time",
        "Unit": "h"
      }
    }
  ],
  "SimulationClassifications": [
    {
      "Name": "CYP2D6_EMs_PMs",
      "Classifiables": [
        "Christensen 2002, 10 mg bid EM",
        "Christensen 2002, 25 mg bid EM",
        "Spigset 1997, 50 mg SD EM",
        "Spigset 1997, 50 mg SD PM",
        "Christensen 2002, 10 mg QD PM",
        "Christensen 2002, 25 mg QD PM"
      ]
    },
    {
      "Name": "Intravenous",
      "Classifiables": [
        "Japanese Society of Hospital Pharmacists 2015, 30 mg iv"
      ]
    },
    {
      "Name": "po, multiple dose",
      "Classifiables": [
        "de Vries 1992, 50 mg bid",
        "Fleishaker 1994, 50/100 mg QD",
        "Labellarte 2004, 150 mg bid",
        "SENSITIVITY, 300mg QD",
        "Spigset 1998, 12.5/25/50/100 mg bid"
      ]
    },
    {
      "Name": "Smoking",
      "Classifiables": [
        "Spigset 1995, 50 mg SD EM non-smoker",
        "Spigset 1995, 50 mg SD EM smoker"
      ]
    },
    {
      "Name": "po, single dose",
      "Classifiables": [
        "Bahrami 2007, 100 mg SD",
        "de Bree 1983, 100 mg SD",
        "de Vries 1993, 100 mg SD",
        "de Vries 1993, 25 mg SD",
        "de Vries 1993, 50 mg SD",
        "Fukasawa 2006, 50 mg SD EM",
        "Japanese Society of Hospital Pharmacists 2015, 100 mg SD",
        "Japanese Society of Hospital Pharmacists 2015, 200 mg SD",
        "Japanese Society of Hospital Pharmacists 2015, 25 mg SD",
        "Japanese Society of Hospital Pharmacists 2015, 50 mg SD",
        "Kunii 2005, 50 mg SD EM",
        "Orlando 2010, 50 mg SD",
        "van Harten 1991, 50 mg SD"
      ]
    }
  ]
}