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Study Design

per sex) were used to guide gene selection for subsequent Xenium assays on adjacent tissue sections from these same 8 donors.

-Experimental Overview +Experimental Overview
Experimental Overview

Examining 13 Xenium samples revealed 5 ARC and 4 VMH neuronal @@ -490,7 +490,7 @@

Study Design

established roles in mediating sex-divergent physiology and behavior, these data provide insights into mechanistic bases of sex bias in neurodevelopmental and neuropsychiatric disorders.

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Sex DE Analysis with Xenium Sex-DE analysis was performed +

Sex DE Analysis with Xenium Sex-DE analysis was performed at the level of Xenium clusters by first subsetting to all cells within the boundaries of the VMH or ARC. Then, cells of each type are tested separately for sex-DE within that domain. Thus, broadly distributed cell @@ -598,4 +598,4 @@

How to Cite

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