From 8c66c758256fd5d71fdfae8152701d846b1024e7 Mon Sep 17 00:00:00 2001
From: nanxstats <nanxstats@gmail.com>
Date: Mon, 20 May 2024 02:00:30 +0000
Subject: [PATCH] =?UTF-8?q?Deploying=20to=20gh-pages=20from=20@=20Merck/fo?=
 =?UTF-8?q?restly@d532bd611f26f5d1c4a7a36cd753b979ced4a9a7=20=F0=9F=9A=80?=
MIME-Version: 1.0
Content-Type: text/plain; charset=UTF-8
Content-Transfer-Encoding: 8bit

---
 apple-touch-icon-120x120.png                  | Bin 6219 -> 6219 bytes
 apple-touch-icon-152x152.png                  | Bin 8019 -> 8019 bytes
 apple-touch-icon-180x180.png                  | Bin 9708 -> 9708 bytes
 apple-touch-icon-60x60.png                    | Bin 3000 -> 3000 bytes
 apple-touch-icon-76x76.png                    | Bin 3635 -> 3635 bytes
 apple-touch-icon.png                          | Bin 9708 -> 9708 bytes
 .../figure-html/unnamed-chunk-5-1.png         | Bin 76234 -> 74799 bytes
 .../figure-html/unnamed-chunk-6-1.png         | Bin 33808 -> 33591 bytes
 .../figure-html/unnamed-chunk-7-1.png         | Bin 53917 -> 53871 bytes
 .../figure-html/unnamed-chunk-8-1.png         | Bin 170017 -> 167490 bytes
 articles/forestly.html                        | 151 +++++++------
 articles/layout.html                          | 201 ++++++++++--------
 favicon-16x16.png                             | Bin 1003 -> 1003 bytes
 favicon-32x32.png                             | Bin 1759 -> 1759 bytes
 pkgdown.yml                                   |   2 +-
 reference/ae_forestly.html                    |  11 +-
 reference/format_ae_forestly.html             |  24 ++-
 reference/plot_dot-1.png                      | Bin 75288 -> 73626 bytes
 reference/plot_errorbar-1.png                 | Bin 83218 -> 82904 bytes
 reference/prepare_ae_forestly.html            |  19 +-
 reference/table_panel-1.png                   | Bin 100184 -> 99620 bytes
 search.json                                   |   2 +-
 22 files changed, 228 insertions(+), 182 deletions(-)

diff --git a/apple-touch-icon-120x120.png b/apple-touch-icon-120x120.png
index d2643675f799382435f021a013885b8db94d87e7..5deefbf8d44fbc152ee3b220dad2cea467c72a89 100644
GIT binary patch
delta 71
zcmX?YaN1x(6^96;72BJD+@6h1BI2S(1|bH9R;CtK24>m@237_JX}&MoCa)Hk!ITjf
L2(X%bM?4<@1;-Rw

delta 71
zcmX?YaN1x(6$d}FpmucfiG+<!BI2TkrXdE#R)*$QCdS$Z237_JJBlvxPF^i8gDG=T
LKWpRUJL35O`C1iG

diff --git a/apple-touch-icon-152x152.png b/apple-touch-icon-152x152.png
index 57c1771cfeff1a96953858fd42082283a3301538..b500466f9be8126815ce14d66e70952f96597845 100644
GIT binary patch
delta 94
zcmca?ciC=26^96;75nV)SgDOoGIDN41|bH9R;CtK2IkrZ237_J2do|&F)%QwmbgZg
jq$HN4TIJ@aWTsUz7#SFu=o*;nVrbZy9^E(jiCjJa5ZW75

delta 94
zcmca?ciC=26$d}Fpw3bD*uxu}WaQioO+yTftqjerOiZ*546F<cYOlU&W?*1YEpd$~
jNl7e8waU#;$xN$cFfuSQ(KRsD#n8ah5n@02iCjJaSP~no

diff --git a/apple-touch-icon-180x180.png b/apple-touch-icon-180x180.png
index 0b5fe7b4cbf9675e965ced4027260719bb460f2f..fd1be683ead0362819eddd423b1046b3bc58f52d 100644
GIT binary patch
delta 71
zcmaFk{l<Gj6^96;75nV)SgDOoTUA7j3_=VHtxPSf49v9+46F<c4p==ln(U)0gDJBy
LJ-Tmlt!h318mtvk

delta 71
zcmaFk{l<Gj6$d}FpzbDy+|Z3pTUA62O+yTftqjerOiZ;646F<cZZCRnKG{cA22*C$
L|M>37wW|35G9DIt

diff --git a/apple-touch-icon-60x60.png b/apple-touch-icon-60x60.png
index df98abadc9dded2cf535048e777ec18ce04623ef..296ef7282b08313f0505ec6f4b5160dd8feb7e93 100644
GIT binary patch
delta 71
zcmdlXzC(OM6^96;6>DjvjoHSgMlMk!gAfBlD^m+A15<4S11kfA@TH%mCrfb4V9Kcd
L@LE3ElRF;(yh{^t

delta 71
zcmdlXzC(OM6$d}Fpyt-xl|CDr8o5LbO+yTftqjerOboRR46F<c^xqy<nJmFAgDDfY
Lp?bz-PwspG>#Y<{

diff --git a/apple-touch-icon-76x76.png b/apple-touch-icon-76x76.png
index bb6722a4808921ca51b5c080562596ed7d8d02a5..48e95453e5ae6a2b5aa248592403298f4d62e76b 100644
GIT binary patch
delta 94
zcmdlivsq?B6^96;6>DjvjoHSgKRj+m1|bH9R;CtK2Bz8u237_J;Y&YBGcYiymbgZg
jq$HN4TIJ@aWTsUz7#SFu=o*;nVrWqN;kA775#D?N4ksH%

delta 94
zcmdlivsq?B6$d}Fpq5U`k8c~B{_waNnuZt{TN#>LnHXss7+4t?$g$qs$-uy%TH+c}
jl9E`GYL%Oxl9^V?U}RuqqHAEPi=iPuB9V3S5#D?NS7;kc

diff --git a/apple-touch-icon.png b/apple-touch-icon.png
index a98f812752d0e396f3f52aefe6a872d8afa638c2..867dd2cae9a120fe6b579d3a453bbbcf1ce0804a 100644
GIT binary patch
delta 71
zcmaFk{l<Gj6^96;6$keVhwhC{TUA7j3_=VHtxPSf3@o$_46F<c%!(%8p6sJ4gDK;#
Lubn=*Ry7|0CIb|>

delta 71
zcmaFk{l<Gj6$d}Fpq@6T&HIf_TUA62O+yTftqjerOw6<m46F<cUU~gpHQ7g122*CX
LxU1OYTGf02DbN)o

diff --git a/articles/forest-plot-static_files/figure-html/unnamed-chunk-5-1.png b/articles/forest-plot-static_files/figure-html/unnamed-chunk-5-1.png
index 9821e16990c7ffdb7464c528a600bdafa32381f0..a0d39b2dd5b1d3fca6013360ff289d2fb8691c70 100644
GIT binary patch
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diff --git a/articles/forestly.html b/articles/forestly.html
index 5fedbe1..bdadef9 100644
--- a/articles/forestly.html
+++ b/articles/forestly.html
@@ -137,18 +137,18 @@ <h2 id="overview">Overview<a class="anchor" aria-label="anchor" href="#overview"
 <div class="container-fluid crosstalk-bscols">
 <div class="row">
 <div class="col-xs-3">
-<div id="filter_ae_485|any adverse events" class="form-group crosstalk-input-select crosstalk-input">
-<label class="control-label" for="filter_ae_485|any adverse events">AE Criteria</label>
+<div id="filter_ae_115e066d-7327-41d9-9f7f-f1509f642743|any adverse events" class="form-group crosstalk-input-select crosstalk-input">
+<label class="control-label" for="filter_ae_115e066d-7327-41d9-9f7f-f1509f642743|any adverse events">AE Criteria</label>
 <div>
-<select></select><script type="application/json" data-for="filter_ae_485|any adverse events">{
+<select></select><script type="application/json" data-for="filter_ae_115e066d-7327-41d9-9f7f-f1509f642743|any adverse events">{
   "items": {
     "value": ["any adverse events", "drug-related adverse events", "serious adverse events"],
     "label": ["any adverse events", "drug-related adverse events", "serious adverse events"]
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-    "serious adverse events": ["284"]
+    "any adverse events": ["1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104", "105", "106", "107", "108", "109", "110", "111", "112", "113", "114", "115", "116", "117", "118", "119", "120", "121", "122", "123", "124", "125", "126", "127", "128", "129", "130", "131", "132", "133", "134", "135", "136", "137", "138", "139", "140", "141", "142", "143", "144", "145", "146", "147", "148", "149", "150", "151", "152", "153", "154", "155", "156", "157", "158", "159", "160", "161", "162", "163", "164", "165", "166", "167", "168", "169", "170", "171", "172", "173", "174", "175", "176", "177", "178", "179", "180", "181", "182", "183", "184", "185", "186", "187", "188", "189", "190", "191", "192", "193", "194", "195", "196", "197", "198", "199", "200", "201", "202", "203", "204", "205", "206", "207", "208", "209", "210", "211", "212"],
+    "drug-related adverse events": ["213", "214", "215", "216", "217", "218", "219", "220", "221", "222", "223", "224", "225", "226", "227", "228", "229", "230", "231", "232", "233", "234", "235", "236", "237", "238", "239", "240", "241", "242", "243", "244", "245", "246", "247", "248", "249", "250", "251", "252", "253", "254", "255", "256", "257", "258", "259", "260", "261", "262", "263", "264", "265", "266", "267", "268", "269", "270", "271", "272", "273", "274", "275", "276", "277", "278", "279", "280", "281", "282", "283", "284", "285", "286", "287", "288", "289", "290", "291", "292", "293", "294", "295", "296", "297", "298", "299", "300", "301", "302", "303", "304", "305", "306", "307", "308", "309", "310", "311", "312", "313", "314", "315", "316", "317", "318", "319", "320", "321", "322"],
+    "serious adverse events": ["323", "324"]
   },
   "group": ["SharedDataac96cb3e"]
 }</script>
@@ -158,17 +158,20 @@ <h2 id="overview">Overview<a class="anchor" aria-label="anchor" href="#overview"
 <div class="col-xs-9">
 <div class="form-group crosstalk-input crosstalk-input-slider js-range-slider" id="filter_subject" style="width: 250px;">
 <label class="control-label" for="filter_subject">Incidence (%) in One or More Treatment Groups</label>
-<input data-skin="shiny" data-type="double" data-min="0" data-max="30" data-from="0" data-to="30" data-step="1" data-grid="true" data-grid-num="10" data-grid-snap="false" data-prettify-separator="," data-keyboard="true" data-keyboard-step="1" data-drag-interval="true" data-data-type="number"><script type="application/json" data-for="filter_subject">{
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TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","Surgical and medical procedures","SURGICAL AND MEDICAL PROCEDURES","SURGICAL AND MEDICAL PROCEDURES","Vascular disorders","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","Cardiac disorders","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","Congenital, familial and genetic disorders","CONGENITAL, FAMILIAL AND GENETIC DISORDERS","Ear and labyrinth disorders","EAR AND LABYRINTH DISORDERS","EAR AND LABYRINTH DISORDERS","Eye disorders","EYE DISORDERS","Gastrointestinal disorders","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","General disorders and administration site conditions","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","Injury, poisoning and procedural complications","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","Investigations","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","Metabolism and nutrition disorders","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","Musculoskeletal and connective tissue disorders","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","Nervous system disorders","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","Psychiatric disorders","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","Renal and urinary disorders","RENAL AND URINARY DISORDERS","Reproductive system and breast disorders","REPRODUCTIVE SYSTEM AND BREAST DISORDERS","Respiratory, thoracic and mediastinal disorders","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","Skin and subcutaneous tissue disorders","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","Vascular disorders","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","Nervous system disorders","NERVOUS SYSTEM 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If not, see <http://www.gnu.org/licenses/>.\n *\n */\n\nfunction(cell, state) {\n  const Plot = createPlotlyComponent(Plotly);\n  var x = [cell.row[\"diff_1\"]];\n  var y = [1];\n  var x_lower = [cell.row[\"lower_1\"]];\n  var x_upper = [cell.row[\"upper_1\"]];\n  var x_range = [-20, 47];\n  var y_range = [0, 2];\n  var vline = [];\n  var text = [x[0] + '(' + x_lower[0] + ', ' + x_upper[0] + ')'];\n  var height = 30;\n  var width = 320;\n  var color = [\"rgba(0, 133, 124, 1)\"];\n  var color_errorbar = [\"rgba(0, 133, 124, 1)\"];\n  var color_vline = \"rgba(0, 0, 0, 0.313725490196078)\";\n  var margin = [0, 20, 0, 0, 0];\n  var x_label = \"\";\n  var showlegend = false;\n  var legend_title = \"\";\n  var legend_position = 0;\n  var legend_label = [\"\"];\n\n  return React.createElement(Plot, {\n    data: [\n      \n  {\n    \"x\": [x[0]],\n    \"y\": [y[0]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[0] - x[0]],\n      arrayminus: [x[0] - x_lower[0]],\n      \"color\": color_errorbar[0]\n    },\n    \"text\": text[0],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[0],\n    \"marker\": {\n      \"color\": [color[0]],\n      \"line\": {\n          \"color\": color[0]\n      }\n    },\n    \"line\": {\n        \"color\": color[0]\n    }\n  }\n    ],\n    \"layout\": {\n      \"height\": height,\n      \"width\": width,\n      \"margin\": {\n        \"b\": margin[0],\n        \"l\": margin[1],\n        \"t\": margin[2],\n        \"r\": margin[3],\n        \"pad\": margin[4]\n      },\n      \"xaxis\": {\n        \"domain\": [0,1],\n        \"title\": {\n          \"text\": x_label,\n          \"standoff\": 0,\n          \"font\": {\n            \"size\": 12\n          }\n        },\n        \"range\": x_range,\n        \"showline\": true,\n        \"ticks\": \"outside\",\n        \"zeroline\": false,\n        \"fixedrange\": true\n      },\n      \"yaxis\": {\n        \"domain\": [0,1],\n        \"title\": \"\",\n        \"range\": y_range,\n        \"showgrid\": false,\n        \"zeroline\": false,\n        \"showticklabels\": false,\n        \"fixedrange\": true\n      },\n      \"shapes\": [\n        {\n          \"type\": \"line\",\n          \"y0\": y_range[0],\n          \"y1\": y_range[1],\n          \"yref\": \"paper\",\n          \"x0\": vline,\n          \"x1\": vline,\n          \"line\": {\n            \"color\": color_vline\n          }\n        }\n      ],\n      \"plot_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"paper_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"hoverlabel\": {\n        \"bgcolor\": \"lightgray\"\n      },\n      \"showlegend\": showlegend,\n      \"hovermode\": \"closest\",\n      \"legend\": {\n        \"title\": {\n          \"text\": legend_title\n        },\n        \"orientation\": \"h\",\n        \"xanchor\": \"center\",\n        \"x\": 0.5,\n        \"y\": legend_position\n      }\n    },\n    \"config\": {\n      \"showSendToCloud\": false,\n      \"displayModeBar\": false\n    }\n  })\n}","footer":"/*\n * Copyright (c) 2023 Merck & Co., Inc., Rahway, NJ, USA and its affiliates.\n * All rights reserved.\n *\n * This file is part of the forestly program.\n *\n * forestly is free software: you can redistribute it and/or modify\n * it under the terms of the GNU General Public License as published by\n * the Free Software Foundation, either version 3 of the License, or\n * (at your option) any later version.\n *\n * This program is distributed in the hope that it will be useful,\n * but WITHOUT ANY WARRANTY; without even the implied warranty of\n * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the\n * GNU General Public License for more details.\n *\n * You should have received a copy of the GNU General Public License\n * along with this program.  If not, see <http://www.gnu.org/licenses/>.\n *\n */\n\nfunction(cell, state) {\n  const Plot = createPlotlyComponent(Plotly);\n  var x = [1];\n  var y = [-1];\n  var x_lower = [0];\n  var x_upper = [0];\n  var x_range = [-20, 47];\n  var y_range = [0, 2];\n  var vline = [];\n  var text = [\"\"];\n  var height = 90;\n  var width = 320;\n  var color = [\"rgba(255, 215, 0, 1)\"];\n  var color_errorbar = [\"rgba(255, 255, 255, 0)\"];\n  var color_vline = \"rgba(0, 0, 0, 0.313725490196078)\";\n  var margin = [70, 20, 0, 0, 0];\n  var x_label = \"Treatment <- Favor -> Placebo\";\n  var showlegend = false;\n  var legend_title = \"\";\n  var legend_position = 0;\n  var legend_label = [\"\"];\n\n  return React.createElement(Plot, {\n    data: [\n      \n  {\n    \"x\": [x[0]],\n    \"y\": [y[0]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[0] - x[0]],\n      arrayminus: [x[0] - x_lower[0]],\n      \"color\": color_errorbar[0]\n    },\n    \"text\": 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@@ -435,20 +438,20 @@ <h2 id="workflow">Workflow<a class="anchor" aria-label="anchor" href="#workflow"
 <div class="container-fluid crosstalk-bscols">
 <div class="row">
 <div class="col-xs-3">
-<div id="filter_ae_1476|any adverse events" class="form-group crosstalk-input-select crosstalk-input">
-<label class="control-label" for="filter_ae_1476|any adverse events">AE Criteria</label>
+<div id="filter_ae_94edabdd-92e7-4abc-a88d-2084cef1fb8e|any adverse events" class="form-group crosstalk-input-select crosstalk-input">
+<label class="control-label" for="filter_ae_94edabdd-92e7-4abc-a88d-2084cef1fb8e|any adverse events">AE Criteria</label>
 <div>
-<select></select><script type="application/json" data-for="filter_ae_1476|any adverse events">{
+<select></select><script type="application/json" data-for="filter_ae_94edabdd-92e7-4abc-a88d-2084cef1fb8e|any adverse events">{
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 <label class="control-label" for="filter_subject">Incidence (%) in One or More Treatment Groups</label>
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If not, see <http://www.gnu.org/licenses/>.\n *\n */\n\nfunction(cell, state) {\n  const Plot = createPlotlyComponent(Plotly);\n  var x = [cell.row[\"prop_1\"], cell.row[\"prop_2\"]];\n  var y = [1, 1];\n  var x_lower = [0];\n  var x_upper = [0];\n  var x_range = [-2, 28];\n  var y_range = [0, 3];\n  var vline = [];\n  var text = [x[0], x[1]];\n  var height = 30;\n  var width = 320;\n  var color = [\"rgba(0, 133, 124, 1)\", \"rgba(102, 32, 58, 1)\"];\n  var color_errorbar = [\"rgba(255, 255, 255, 0)\"];\n  var color_vline = \"rgba(0, 0, 0, 0.313725490196078)\";\n  var margin = [0, 0, 0, 0, 0];\n  var x_label = \"\";\n  var showlegend = false;\n  var legend_title = \"\";\n  var legend_position = 0;\n  var legend_label = [\"\"];\n\n  return React.createElement(Plot, {\n    data: [\n      \n  {\n    \"x\": [x[0]],\n    \"y\": [y[0]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[0] - x[0]],\n      arrayminus: [x[0] - x_lower[0]],\n      \"color\": color_errorbar[0]\n    },\n    \"text\": text[0],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[0],\n    \"marker\": {\n      \"color\": [color[0]],\n      \"line\": {\n          \"color\": color[0]\n      }\n    },\n    \"line\": {\n        \"color\": color[0]\n    }\n  },\n  {\n    \"x\": [x[1]],\n    \"y\": [y[1]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[1] - x[1]],\n      arrayminus: [x[1] - x_lower[1]],\n      \"color\": color_errorbar[1]\n    },\n    \"text\": text[1],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[1],\n    \"marker\": {\n      \"color\": [color[1]],\n      \"line\": {\n          \"color\": color[1]\n      }\n    },\n    \"line\": {\n        \"color\": color[1]\n    }\n  }\n    ],\n    \"layout\": {\n      \"height\": height,\n      \"width\": width,\n      \"margin\": {\n        \"b\": margin[0],\n        \"l\": margin[1],\n        \"t\": margin[2],\n        \"r\": margin[3],\n        \"pad\": margin[4]\n      },\n      \"xaxis\": {\n        \"domain\": [0,1],\n        \"title\": {\n          \"text\": x_label,\n          \"standoff\": 0,\n          \"font\": {\n            \"size\": 12\n          }\n        },\n        \"range\": x_range,\n        \"showline\": true,\n        \"ticks\": \"outside\",\n        \"zeroline\": false,\n        \"fixedrange\": true\n      },\n      \"yaxis\": {\n        \"domain\": [0,1],\n        \"title\": \"\",\n        \"range\": y_range,\n        \"showgrid\": false,\n        \"zeroline\": false,\n        \"showticklabels\": false,\n        \"fixedrange\": true\n      },\n      \"shapes\": [\n        {\n          \"type\": \"line\",\n          \"y0\": y_range[0],\n          \"y1\": y_range[1],\n          \"yref\": \"paper\",\n          \"x0\": vline,\n          \"x1\": vline,\n          \"line\": {\n            \"color\": color_vline\n          }\n        }\n      ],\n      \"plot_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"paper_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"hoverlabel\": {\n        \"bgcolor\": \"lightgray\"\n      },\n      \"showlegend\": showlegend,\n      \"hovermode\": \"closest\",\n      \"legend\": {\n        \"title\": {\n          \"text\": legend_title\n        },\n        \"orientation\": \"h\",\n        \"xanchor\": \"center\",\n        \"x\": 0.5,\n        \"y\": legend_position\n      }\n    },\n    \"config\": {\n      \"showSendToCloud\": false,\n      \"displayModeBar\": false\n    }\n  })\n}","footer":"/*\n * Copyright (c) 2023 Merck & Co., Inc., Rahway, NJ, USA and its affiliates.\n * All rights reserved.\n *\n * This file is part of the forestly program.\n *\n * forestly is free software: you can redistribute it and/or modify\n * it under the terms of the GNU General Public License as published by\n * the Free Software Foundation, either version 3 of the License, or\n * (at your option) any later version.\n *\n * This program is distributed in the hope that it will be useful,\n * but WITHOUT ANY WARRANTY; without even the implied warranty of\n * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  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DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","Renal and urinary disorders","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","Reproductive system and breast disorders","REPRODUCTIVE SYSTEM AND BREAST DISORDERS","REPRODUCTIVE SYSTEM AND BREAST DISORDERS","Respiratory, thoracic and mediastinal disorders","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","Skin and subcutaneous tissue 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See the\n * GNU General Public License for more details.\n *\n * You should have received a copy of the GNU General Public License\n * along with this program.  If not, see <http://www.gnu.org/licenses/>.\n *\n */\n\nfunction(cell, state) {\n  const Plot = createPlotlyComponent(Plotly);\n  var x = [cell.row[\"prop_1\"], cell.row[\"prop_2\"]];\n  var y = [1, 1];\n  var x_lower = [0];\n  var x_upper = [0];\n  var x_range = [-2, 58];\n  var y_range = [0, 3];\n  var vline = [];\n  var text = [x[0], x[1]];\n  var height = 30;\n  var width = 320;\n  var color = [\"rgba(0, 133, 124, 1)\", \"rgba(102, 32, 58, 1)\"];\n  var color_errorbar = [\"rgba(255, 255, 255, 0)\"];\n  var color_vline = \"rgba(0, 0, 0, 0.313725490196078)\";\n  var margin = [0, 0, 0, 0, 0];\n  var x_label = \"\";\n  var showlegend = false;\n  var legend_title = \"\";\n  var legend_position = 0;\n  var legend_label = [\"\"];\n\n  return React.createElement(Plot, {\n    data: [\n      \n  {\n    \"x\": [x[0]],\n    \"y\": [y[0]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[0] - x[0]],\n      arrayminus: [x[0] - x_lower[0]],\n      \"color\": color_errorbar[0]\n    },\n    \"text\": text[0],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[0],\n    \"marker\": {\n      \"color\": [color[0]],\n      \"line\": {\n          \"color\": color[0]\n      }\n    },\n    \"line\": {\n        \"color\": color[0]\n    }\n  },\n  {\n    \"x\": [x[1]],\n    \"y\": [y[1]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[1] - x[1]],\n      arrayminus: [x[1] - x_lower[1]],\n      \"color\": color_errorbar[1]\n    },\n    \"text\": text[1],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[1],\n    \"marker\": {\n      \"color\": [color[1]],\n      \"line\": {\n          \"color\": color[1]\n      }\n    },\n    \"line\": {\n        \"color\": color[1]\n    }\n  }\n    ],\n    \"layout\": {\n      \"height\": height,\n      \"width\": width,\n      \"margin\": {\n        \"b\": margin[0],\n        \"l\": margin[1],\n        \"t\": margin[2],\n        \"r\": margin[3],\n        \"pad\": margin[4]\n      },\n      \"xaxis\": {\n        \"domain\": [0,1],\n        \"title\": {\n          \"text\": x_label,\n          \"standoff\": 0,\n          \"font\": {\n            \"size\": 12\n          }\n        },\n        \"range\": x_range,\n        \"showline\": true,\n        \"ticks\": \"outside\",\n        \"zeroline\": false,\n        \"fixedrange\": true\n      },\n      \"yaxis\": {\n        \"domain\": [0,1],\n        \"title\": \"\",\n        \"range\": y_range,\n        \"showgrid\": false,\n        \"zeroline\": false,\n        \"showticklabels\": false,\n        \"fixedrange\": true\n      },\n      \"shapes\": [\n        {\n          \"type\": \"line\",\n          \"y0\": y_range[0],\n          \"y1\": y_range[1],\n          \"yref\": \"paper\",\n          \"x0\": vline,\n          \"x1\": vline,\n          \"line\": {\n            \"color\": color_vline\n          }\n        }\n      ],\n      \"plot_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"paper_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"hoverlabel\": {\n        \"bgcolor\": \"lightgray\"\n      },\n      \"showlegend\": showlegend,\n      \"hovermode\": \"closest\",\n      \"legend\": {\n        \"title\": {\n          \"text\": legend_title\n        },\n        \"orientation\": \"h\",\n        \"xanchor\": \"center\",\n        \"x\": 0.5,\n        \"y\": legend_position\n      }\n    },\n    \"config\": {\n      \"showSendToCloud\": false,\n      \"displayModeBar\": false\n    }\n  })\n}","footer":"/*\n * Copyright (c) 2023 Merck & Co., Inc., Rahway, NJ, USA and its affiliates.\n * All rights reserved.\n *\n * This file is part of the forestly program.\n *\n * forestly is free software: you can redistribute it and/or modify\n * it under the terms of the GNU General Public License as published by\n * the Free Software Foundation, either version 3 of the License, or\n * (at your option) any later version.\n *\n * This program is distributed in the hope that it will be useful,\n * but WITHOUT ANY WARRANTY; without even the implied warranty of\n * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the\n * GNU General Public License for more details.\n *\n * You should have received a copy of the GNU General Public License\n * along with this program.  If not, see <http://www.gnu.org/licenses/>.\n *\n */\n\nfunction(cell, state) {\n  const Plot = createPlotlyComponent(Plotly);\n  var x = [1, 2];\n  var y = [-1, -1];\n  var x_lower = [0];\n  var x_upper = [0];\n  var x_range = [-2, 58];\n  var y_range = [0, 3];\n  var vline = [];\n  var text = [\"\", \"\"];\n  var height = 90;\n  var width = 320;\n  var color = [\"rgba(0, 133, 124, 1)\", \"rgba(102, 32, 58, 1)\"];\n  var color_errorbar = [\"rgba(255, 255, 255, 0)\"];\n  var color_vline = \"rgba(0, 0, 0, 0.313725490196078)\";\n  var margin = [70, 0, 0, 0, 0];\n  var x_label = \"\";\n  var showlegend = true;\n  var legend_title = \"\";\n  var legend_position = -0.8;\n  var legend_label = [\"Low Dose\", \"Placebo\"];\n\n  return React.createElement(Plot, {\n    data: [\n      \n  {\n    \"x\": [x[0]],\n    \"y\": [y[0]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[0] - x[0]],\n      arrayminus: [x[0] - x_lower[0]],\n      \"color\": color_errorbar[0]\n    },\n    \"text\": text[0],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[0],\n    \"marker\": {\n      \"color\": [color[0]],\n      \"line\": {\n          \"color\": color[0]\n      }\n    },\n    \"line\": {\n        \"color\": color[0]\n    }\n  },\n  {\n    \"x\": [x[1]],\n    \"y\": [y[1]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[1] - x[1]],\n      arrayminus: [x[1] - x_lower[1]],\n      \"color\": color_errorbar[1]\n    },\n    \"text\": text[1],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[1],\n    \"marker\": {\n      \"color\": [color[1]],\n      \"line\": {\n          \"color\": color[1]\n      }\n    },\n    \"line\": {\n        \"color\": color[1]\n    }\n  }\n    ],\n    \"layout\": {\n      \"height\": height,\n      \"width\": width,\n      \"margin\": {\n        \"b\": margin[0],\n        \"l\": margin[1],\n        \"t\": margin[2],\n        \"r\": margin[3],\n        \"pad\": margin[4]\n      },\n      \"xaxis\": {\n        \"domain\": [0,1],\n        \"title\": {\n          \"text\": x_label,\n          \"standoff\": 0,\n          \"font\": {\n            \"size\": 12\n          }\n        },\n        \"range\": x_range,\n        \"showline\": true,\n        \"ticks\": \"outside\",\n        \"zeroline\": false,\n        \"fixedrange\": true\n      },\n      \"yaxis\": {\n        \"domain\": [0,1],\n        \"title\": \"\",\n        \"range\": y_range,\n        \"showgrid\": false,\n        \"zeroline\": false,\n        \"showticklabels\": false,\n        \"fixedrange\": true\n      },\n      \"shapes\": [\n        {\n          \"type\": \"line\",\n          \"y0\": y_range[0],\n          \"y1\": y_range[1],\n          \"yref\": \"paper\",\n          \"x0\": vline,\n          \"x1\": vline,\n          \"line\": {\n            \"color\": color_vline\n          }\n        }\n      ],\n      \"plot_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"paper_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"hoverlabel\": {\n        \"bgcolor\": \"lightgray\"\n      },\n      \"showlegend\": showlegend,\n      \"hovermode\": \"closest\",\n      \"legend\": {\n        \"title\": {\n          \"text\": legend_title\n        },\n        \"orientation\": \"h\",\n        \"xanchor\": \"center\",\n        \"x\": 0.5,\n        \"y\": legend_position\n      }\n    },\n    \"config\": {\n      \"showSendToCloud\": false,\n      \"displayModeBar\": false\n    }\n  })\n}","html":true,"width":320,"align":"center","style":{"font-size":"0px","padding":"0px","margin":"0px"},"footerStyle":{"font-size":"0px","padding":"0px","margin":"0px"},"show":true},{"id":"diff_fig","name":"diff_fig","type":"logical","header":"Risk Difference (%) + 95% CI <br> vs. Placebo","defaultSortDesc":true,"cell":"/*\n * Copyright (c) 2023 Merck & Co., Inc., Rahway, NJ, USA and its affiliates.\n * All rights reserved.\n *\n * This file is part of the forestly program.\n *\n * forestly is free software: you can redistribute it and/or modify\n * it under the terms of the GNU General Public License as published by\n * the Free Software Foundation, either version 3 of the License, or\n * (at your option) any later version.\n *\n * This program is distributed in the hope that it will be useful,\n * but WITHOUT ANY WARRANTY; without even the implied warranty of\n * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the\n * GNU General Public License for more details.\n *\n * You should have received a copy of the GNU General Public License\n * along with this program.  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See the\n * GNU General Public License for more details.\n *\n * You should have received a copy of the GNU General Public License\n * along with this program.  If not, see <http://www.gnu.org/licenses/>.\n *\n */\n\nfunction(cell, state) {\n  const Plot = createPlotlyComponent(Plotly);\n  var x = [1];\n  var y = [-1];\n  var x_lower = [0];\n  var x_upper = [0];\n  var x_range = [-21, 47];\n  var y_range = [0, 2];\n  var vline = [];\n  var text = [\"\"];\n  var height = 90;\n  var width = 320;\n  var color = [\"rgba(255, 215, 0, 1)\"];\n  var color_errorbar = [\"rgba(255, 255, 255, 0)\"];\n  var color_vline = \"rgba(0, 0, 0, 0.313725490196078)\";\n  var margin = [70, 20, 0, 0, 0];\n  var x_label = \"Treatment <- Favor -> Placebo\";\n  var showlegend = false;\n  var legend_title = \"\";\n  var legend_position = 0;\n  var legend_label = [\"\"];\n\n  return React.createElement(Plot, {\n    data: [\n      \n  {\n    \"x\": [x[0]],\n    \"y\": [y[0]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[0] - x[0]],\n      arrayminus: [x[0] - x_lower[0]],\n      \"color\": color_errorbar[0]\n    },\n    \"text\": 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-<div id="filter_ae_9983|any adverse events" class="form-group crosstalk-input-select crosstalk-input">
-<label class="control-label" for="filter_ae_9983|any adverse events">AE Criteria</label>
+<div id="filter_ae_c5f50a46-283c-42c8-a6a0-df45f500b38f|any adverse events" class="form-group crosstalk-input-select crosstalk-input">
+<label class="control-label" for="filter_ae_c5f50a46-283c-42c8-a6a0-df45f500b38f|any adverse events">AE Criteria</label>
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+<select></select><script type="application/json" data-for="filter_ae_c5f50a46-283c-42c8-a6a0-df45f500b38f|any adverse events">{
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@@ -501,17 +507,20 @@ <h2 id="workflow">Workflow<a class="anchor" aria-label="anchor" href="#workflow"
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pain","Constipation","Diarrhoea","Dyspepsia","Dysphagia","Flatulence","Gastrooesophageal reflux disease","Glossitis","Hiatus hernia","Nausea","Rectal haemorrhage","Vomiting","General disorders and administration site conditions","Application site bleeding","Application site dermatitis","Application site desquamation","Application site discolouration","Application site erythema","Application site induration","Application site irritation","Application site pruritus","Application site reaction","Application site swelling","Application site urticaria","Application site vesicles","Application site warmth","Asthenia","Chills","Fatigue","Inflammation","Malaise","Oedema","Oedema peripheral","Pain","Pyrexia","Secretion discharge","Sudden death","Swelling","Ulcer","Hepatobiliary disorders","Hyperbilirubinaemia","Immune system disorders","Hypersensitivity","Infections and infestations","Bronchitis","Cellulitis","Cervicitis","Cystitis","Ear infection","Gastroenteritis viral","Influenza","Localised infection","Nasopharyngitis","Pneumonia","Upper respiratory tract infection","Urinary tract infection","Vaginal mycosis","Viral infection","Injury, poisoning and procedural complications","Contusion","Excoriation","Fall","Hip fracture","Joint dislocation","Skin laceration","Wound","Investigations","Blood alkaline phosphatase increased","Blood creatine phosphokinase increased","Blood glucose increased","Blood urine present","Body temperature increased","Cystoscopy","Electrocardiogram st segment depression","Electrocardiogram t wave amplitude decreased","Electrocardiogram t wave inversion","Heart rate increased","Heart rate irregular","Nasal mucosa biopsy","Metabolism and nutrition disorders","Decreased appetite","Dehydration","Diabetes mellitus","Food craving","Hyponatraemia","Increased appetite","Musculoskeletal and connective tissue disorders","Arthralgia","Back pain","Muscle spasms","Muscular weakness","Pain in extremity","Shoulder pain","Neoplasms benign, malignant and unspecified (incl cysts and polyps)","Colon cancer","Malignant fibrous histiocytoma","Nervous system disorders","Balance disorder","Complex partial seizures","Coordination abnormal","Dizziness","Headache","Hemianopia homonymous","Lethargy","Paraesthesia oral","Parkinson's disease","Psychomotor hyperactivity","Somnolence","Stupor","Syncope","Transient ischaemic attack","Psychiatric disorders","Agitation","Anxiety","Completed suicide","Confusional state","Delusion","Depressed mood","Disorientation","Insomnia","Irritability","Restlessness","Renal and urinary disorders","Dysuria","Incontinence","Micturition urgency","Nephrolithiasis","Pollakiuria","Reproductive system and breast disorders","Benign prostatic hyperplasia","Pelvic pain","Respiratory, thoracic and mediastinal disorders","Cough","Dysphonia","Dyspnoea","Emphysema","Epistaxis","Haemoptysis","Nasal congestion","Pharyngolaryngeal pain","Postnasal drip","Rales","Rhinorrhoea","Skin and subcutaneous tissue disorders","Alopecia","Blister","Cold sweat","Dermatitis contact","Drug eruption","Erythema","Hyperhidrosis","Pruritus","Pruritus generalised","Rash","Rash erythematous","Rash pruritic","Skin exfoliation","Skin irritation","Skin ulcer","Urticaria","Surgical and medical procedures","Cataract operation","Eye laser surgery","Vascular disorders","Hot flush","Hypertension","Hypotension","Orthostatic hypotension","Cardiac disorders","Atrial fibrillation","Atrial flutter","Atrioventricular block first degree","Atrioventricular block second degree","Bradycardia","Bundle branch block right","Cardiac failure congestive","Myocardial infarction","Palpitations","Sinus arrhythmia","Sinus bradycardia","Supraventricular extrasystoles","Ventricular extrasystoles","Wolff-parkinson-white syndrome","Congenital, familial and genetic disorders","Ventricular septal defect","Ear and labyrinth disorders","Vertigo","Eye disorders","Vision blurred","Gastrointestinal disorders","Abdominal pain","Diarrhoea","Dyspepsia","Gastrooesophageal reflux disease","Nausea","Vomiting","General disorders and administration site conditions","Application site bleeding","Application site dermatitis","Application site desquamation","Application site discolouration","Application site erythema","Application site induration","Application site irritation","Application site pruritus","Application site reaction","Application site swelling","Application site urticaria","Application site vesicles","Application site warmth","Asthenia","Chills","Fatigue","Malaise","Oedema","Pain","Injury, poisoning and procedural complications","Fall","Skin laceration","Wound","Investigations","Blood creatine phosphokinase increased","Body temperature increased","Electrocardiogram st segment depression","Heart rate increased","Heart rate irregular","Metabolism and nutrition disorders","Decreased appetite","Food craving","Increased appetite","Musculoskeletal and connective tissue disorders","Shoulder pain","Nervous system disorders","Balance disorder","Complex partial seizures","Coordination abnormal","Dizziness","Headache","Lethargy","Paraesthesia oral","Somnolence","Stupor","Syncope","Transient ischaemic attack","Psychiatric disorders","Agitation","Anxiety","Confusional state","Depressed mood","Irritability","Restlessness","Reproductive system and breast disorders","Pelvic pain","Respiratory, thoracic and mediastinal disorders","Dyspnoea","Emphysema","Skin and subcutaneous tissue disorders","Blister","Cold sweat","Dermatitis contact","Erythema","Hyperhidrosis","Pruritus","Pruritus generalised","Rash","Rash erythematous","Rash pruritic","Skin exfoliation","Skin irritation","Skin ulcer","Urticaria","Vascular disorders","Hypertension","Hypotension","Orthostatic hypotension","Nervous system disorders","Syncope"],"soc_name":["Cardiac disorders","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","Congenital, familial and genetic disorders","CONGENITAL, FAMILIAL AND GENETIC DISORDERS","Ear and labyrinth disorders","EAR AND LABYRINTH DISORDERS","EAR AND LABYRINTH DISORDERS","EAR AND LABYRINTH DISORDERS","Eye disorders","EYE DISORDERS","EYE DISORDERS","EYE DISORDERS","EYE DISORDERS","EYE DISORDERS","EYE DISORDERS","Gastrointestinal disorders","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","General disorders and administration site conditions","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","Hepatobiliary disorders","HEPATOBILIARY DISORDERS","Immune system disorders","IMMUNE SYSTEM DISORDERS","Infections and infestations","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","Injury, poisoning and procedural complications","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","Investigations","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","Metabolism and nutrition disorders","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","Musculoskeletal and connective tissue disorders","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","Neoplasms benign, malignant and unspecified (incl cysts and polyps)","NEOPLASMS BENIGN, MALIGNANT AND UNSPECIFIED (INCL CYSTS AND POLYPS)","NEOPLASMS BENIGN, MALIGNANT AND UNSPECIFIED (INCL CYSTS AND POLYPS)","Nervous system disorders","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","Psychiatric disorders","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","Renal and urinary disorders","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","Reproductive system and breast disorders","REPRODUCTIVE SYSTEM AND BREAST DISORDERS","REPRODUCTIVE SYSTEM AND BREAST DISORDERS","Respiratory, thoracic and mediastinal disorders","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","Skin and subcutaneous tissue disorders","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","Surgical and medical procedures","SURGICAL AND MEDICAL PROCEDURES","SURGICAL AND MEDICAL PROCEDURES","Vascular disorders","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","Cardiac disorders","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","Congenital, familial and genetic disorders","CONGENITAL, FAMILIAL AND GENETIC DISORDERS","Ear and labyrinth disorders","EAR AND LABYRINTH DISORDERS","Eye disorders","EYE DISORDERS","Gastrointestinal disorders","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","General disorders and administration site conditions","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","Injury, poisoning and procedural complications","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","Investigations","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","Metabolism and nutrition disorders","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","Musculoskeletal and connective tissue disorders","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","Nervous system disorders","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","Psychiatric disorders","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","Reproductive system and breast disorders","REPRODUCTIVE SYSTEM AND BREAST DISORDERS","Respiratory, thoracic and mediastinal disorders","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","Skin and subcutaneous tissue disorders","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","Vascular disorders","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","Nervous system disorders","NERVOUS SYSTEM 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If not, see <http://www.gnu.org/licenses/>.\n *\n */\n\nfunction(cell, state) {\n  const Plot = createPlotlyComponent(Plotly);\n  var x = [1, 2];\n  var y = [-1, -1];\n  var x_lower = [0];\n  var x_upper = [0];\n  var x_range = [-2, 58];\n  var y_range = [0, 3];\n  var vline = [];\n  var text = [\"\", \"\"];\n  var height = 90;\n  var width = 320;\n  var color = [\"rgba(0, 133, 124, 1)\", \"rgba(102, 32, 58, 1)\"];\n  var color_errorbar = [\"rgba(255, 255, 255, 0)\"];\n  var color_vline = \"rgba(0, 0, 0, 0.313725490196078)\";\n  var margin = [70, 0, 0, 0, 0];\n  var x_label = \"\";\n  var showlegend = true;\n  var legend_title = \"\";\n  var legend_position = -0.8;\n  var legend_label = [\"Low Dose\", \"Placebo\"];\n\n  return React.createElement(Plot, {\n    data: [\n      \n  {\n    \"x\": [x[0]],\n    \"y\": [y[0]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[0] - x[0]],\n      arrayminus: [x[0] - x_lower[0]],\n      \"color\": color_errorbar[0]\n    },\n    \"text\": text[0],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[0],\n    \"marker\": {\n      \"color\": [color[0]],\n      \"line\": {\n          \"color\": color[0]\n      }\n    },\n    \"line\": {\n        \"color\": color[0]\n    }\n  },\n  {\n    \"x\": [x[1]],\n    \"y\": [y[1]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[1] - x[1]],\n      arrayminus: [x[1] - x_lower[1]],\n      \"color\": color_errorbar[1]\n    },\n    \"text\": text[1],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[1],\n    \"marker\": {\n      \"color\": [color[1]],\n      \"line\": {\n          \"color\": color[1]\n      }\n    },\n    \"line\": {\n        \"color\": color[1]\n    }\n  }\n    ],\n    \"layout\": {\n      \"height\": height,\n      \"width\": width,\n      \"margin\": {\n        \"b\": margin[0],\n        \"l\": margin[1],\n        \"t\": margin[2],\n        \"r\": margin[3],\n        \"pad\": margin[4]\n      },\n      \"xaxis\": {\n        \"domain\": [0,1],\n        \"title\": {\n          \"text\": x_label,\n          \"standoff\": 0,\n          \"font\": {\n            \"size\": 12\n          }\n        },\n        \"range\": x_range,\n        \"showline\": true,\n        \"ticks\": \"outside\",\n        \"zeroline\": false,\n        \"fixedrange\": true\n      },\n      \"yaxis\": {\n        \"domain\": [0,1],\n        \"title\": \"\",\n        \"range\": y_range,\n        \"showgrid\": false,\n        \"zeroline\": false,\n        \"showticklabels\": false,\n        \"fixedrange\": true\n      },\n      \"shapes\": [\n        {\n          \"type\": \"line\",\n          \"y0\": y_range[0],\n          \"y1\": y_range[1],\n          \"yref\": \"paper\",\n          \"x0\": vline,\n          \"x1\": vline,\n          \"line\": {\n            \"color\": color_vline\n          }\n        }\n      ],\n      \"plot_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"paper_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"hoverlabel\": {\n        \"bgcolor\": \"lightgray\"\n      },\n      \"showlegend\": showlegend,\n      \"hovermode\": \"closest\",\n      \"legend\": {\n        \"title\": {\n          \"text\": legend_title\n        },\n        \"orientation\": \"h\",\n        \"xanchor\": \"center\",\n        \"x\": 0.5,\n        \"y\": legend_position\n      }\n    },\n    \"config\": {\n      \"showSendToCloud\": false,\n      \"displayModeBar\": false\n    }\n  })\n}","html":true,"width":320,"align":"center","style":{"font-size":"0px","padding":"0px","margin":"0px"},"footerStyle":{"font-size":"0px","padding":"0px","margin":"0px"},"show":true},{"id":"diff_fig","name":"diff_fig","type":"logical","header":"Risk Difference (%) + 95% CI <br> vs. Placebo","defaultSortDesc":true,"cell":"/*\n * Copyright (c) 2023 Merck & Co., Inc., Rahway, NJ, USA and its affiliates.\n * All rights reserved.\n *\n * This file is part of the forestly program.\n *\n * forestly is free software: you can redistribute it and/or modify\n * it under the terms of the GNU General Public License as published by\n * the Free Software Foundation, either version 3 of the License, or\n * (at your option) any later version.\n *\n * This program is distributed in the hope that it will be useful,\n * but WITHOUT ANY WARRANTY; without even the implied warranty of\n * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the\n * GNU General Public License for more details.\n *\n * You should have received a copy of the GNU General Public License\n * along with this program.  If not, see <http://www.gnu.org/licenses/>.\n *\n */\n\nfunction(cell, state) {\n  const Plot = createPlotlyComponent(Plotly);\n  var x = [cell.row[\"diff_1\"]];\n  var y = [1];\n  var x_lower = [cell.row[\"lower_1\"]];\n  var x_upper = [cell.row[\"upper_1\"]];\n  var x_range = [-21, 47];\n  var y_range = [0, 2];\n  var vline = [];\n  var text = [x[0] + '(' + x_lower[0] + ', ' + x_upper[0] + ')'];\n  var height = 30;\n  var width = 320;\n  var color = [\"rgba(0, 133, 124, 1)\"];\n  var color_errorbar = [\"rgba(0, 133, 124, 1)\"];\n  var color_vline = \"rgba(0, 0, 0, 0.313725490196078)\";\n  var margin = [0, 20, 0, 0, 0];\n  var x_label = \"\";\n  var showlegend = false;\n  var legend_title = \"\";\n  var legend_position = 0;\n  var legend_label = [\"\"];\n\n  return React.createElement(Plot, {\n    data: [\n      \n  {\n    \"x\": [x[0]],\n    \"y\": [y[0]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[0] - x[0]],\n      arrayminus: [x[0] - x_lower[0]],\n      \"color\": color_errorbar[0]\n    },\n    \"text\": text[0],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[0],\n    \"marker\": {\n      \"color\": [color[0]],\n      \"line\": {\n          \"color\": color[0]\n      }\n    },\n    \"line\": {\n        \"color\": color[0]\n    }\n  }\n    ],\n    \"layout\": {\n      \"height\": height,\n      \"width\": width,\n      \"margin\": {\n        \"b\": margin[0],\n        \"l\": margin[1],\n        \"t\": margin[2],\n        \"r\": margin[3],\n        \"pad\": margin[4]\n      },\n      \"xaxis\": {\n        \"domain\": [0,1],\n        \"title\": {\n          \"text\": x_label,\n          \"standoff\": 0,\n          \"font\": {\n            \"size\": 12\n          }\n        },\n        \"range\": x_range,\n        \"showline\": true,\n        \"ticks\": \"outside\",\n        \"zeroline\": false,\n        \"fixedrange\": true\n      },\n      \"yaxis\": {\n        \"domain\": [0,1],\n        \"title\": \"\",\n        \"range\": y_range,\n        \"showgrid\": false,\n        \"zeroline\": false,\n        \"showticklabels\": false,\n        \"fixedrange\": true\n      },\n      \"shapes\": [\n        {\n          \"type\": \"line\",\n          \"y0\": y_range[0],\n          \"y1\": y_range[1],\n          \"yref\": \"paper\",\n          \"x0\": vline,\n          \"x1\": vline,\n          \"line\": {\n            \"color\": color_vline\n          }\n        }\n      ],\n      \"plot_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"paper_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"hoverlabel\": {\n        \"bgcolor\": \"lightgray\"\n      },\n      \"showlegend\": showlegend,\n      \"hovermode\": \"closest\",\n      \"legend\": {\n        \"title\": {\n          \"text\": legend_title\n        },\n        \"orientation\": \"h\",\n        \"xanchor\": \"center\",\n        \"x\": 0.5,\n        \"y\": legend_position\n      }\n    },\n    \"config\": {\n      \"showSendToCloud\": false,\n      \"displayModeBar\": false\n    }\n  })\n}","footer":"/*\n * Copyright (c) 2023 Merck & Co., Inc., Rahway, NJ, USA and its affiliates.\n * All rights reserved.\n *\n * This file is part of the forestly program.\n *\n * forestly is free software: you can redistribute it and/or modify\n * it under the terms of the GNU General Public License as published by\n * the Free Software Foundation, either version 3 of the License, or\n * (at your option) any later version.\n *\n * This program is distributed in the hope that it will be useful,\n * but WITHOUT ANY WARRANTY; without even the implied warranty of\n * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the\n * GNU General Public License for more details.\n *\n * You should have received a copy of the GNU General Public License\n * along with this program.  If not, see <http://www.gnu.org/licenses/>.\n *\n */\n\nfunction(cell, state) {\n  const Plot = createPlotlyComponent(Plotly);\n  var x = [1];\n  var y = [-1];\n  var x_lower = [0];\n  var x_upper = [0];\n  var x_range = [-21, 47];\n  var y_range = [0, 2];\n  var vline = [];\n  var text = [\"\"];\n  var height = 90;\n  var width = 320;\n  var color = [\"rgba(255, 215, 0, 1)\"];\n  var color_errorbar = [\"rgba(255, 255, 255, 0)\"];\n  var color_vline = \"rgba(0, 0, 0, 0.313725490196078)\";\n  var margin = [70, 20, 0, 0, 0];\n  var x_label = \"Treatment <- Favor -> Placebo\";\n  var showlegend = false;\n  var legend_title = \"\";\n  var legend_position = 0;\n  var legend_label = [\"\"];\n\n  return React.createElement(Plot, {\n    data: [\n      \n  {\n    \"x\": [x[0]],\n    \"y\": [y[0]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[0] - x[0]],\n      arrayminus: [x[0] - x_lower[0]],\n      \"color\": color_errorbar[0]\n    },\n    \"text\": 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})\n}","html":true,"width":320,"align":"center","style":{"font-size":"0px","padding":"0px","margin":"0px"},"footerStyle":{"font-size":"0px","padding":"0px","margin":"0px"},"show":true},{"id":"n_1","name":"n_1","type":"numeric","header":"n","defaultSortDesc":true,"minWidth":40,"align":"center","show":true},{"id":"n_2","name":"n_2","type":"numeric","header":"n","defaultSortDesc":true,"minWidth":40,"align":"center","show":true},{"id":"prop_1","name":"prop_1","type":"numeric","header":"(%)","defaultSortDesc":true,"format":{"cell":{"prefix":"(","suffix":")","digits":1},"aggregated":{"prefix":"(","suffix":")","digits":1}},"minWidth":60,"align":"center","show":true},{"id":"prop_2","name":"prop_2","type":"numeric","header":"(%)","defaultSortDesc":true,"format":{"cell":{"prefix":"(","suffix":")","digits":1},"aggregated":{"prefix":"(","suffix":")","digits":1}},"minWidth":60,"align":"center","show":true},{"id":"diff_1","name":"diff_1","type":"numeric","header":"Low 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@@ -616,20 +625,20 @@ <h2 id="define-metadata">Define metadata<a class="anchor" aria-label="anchor" hr
 <div class="container-fluid crosstalk-bscols">
 <div class="row">
 <div class="col-xs-3">
-<div id="filter_ae_2615|any adverse events" class="form-group crosstalk-input-select crosstalk-input">
-<label class="control-label" for="filter_ae_2615|any adverse events">AE Criteria</label>
+<div id="filter_ae_59400cb9-aa47-4a05-9555-687c4ced2af2|any adverse events" class="form-group crosstalk-input-select crosstalk-input">
+<label class="control-label" for="filter_ae_59400cb9-aa47-4a05-9555-687c4ced2af2|any adverse events">AE Criteria</label>
 <div>
-<select></select><script type="application/json" data-for="filter_ae_2615|any adverse events">{
+<select></select><script type="application/json" data-for="filter_ae_59400cb9-aa47-4a05-9555-687c4ced2af2|any adverse events">{
   "items": {
     "value": ["any adverse events", "drug-related adverse events", "serious adverse events"],
     "label": ["any adverse events", "drug-related adverse events", "serious adverse events"]
   },
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mood","Disorientation","Insomnia","Irritability","Restlessness","Dysuria","Enuresis","Incontinence","Micturition urgency","Nephrolithiasis","Pollakiuria","Benign prostatic hyperplasia","Pelvic pain","Cough","Dysphonia","Dyspnoea","Emphysema","Epistaxis","Haemoptysis","Nasal congestion","Pharyngolaryngeal pain","Postnasal drip","Rales","Rhinorrhoea","Alopecia","Blister","Cold sweat","Dermatitis atopic","Dermatitis contact","Drug eruption","Erythema","Hyperhidrosis","Pruritus","Pruritus generalised","Rash","Rash erythematous","Rash pruritic","Skin exfoliation","Skin irritation","Skin ulcer","Urticaria","Cataract operation","Eye laser surgery","Hot flush","Hypertension","Hypotension","Orthostatic hypotension","Atrial fibrillation","Atrial flutter","Atrioventricular block first degree","Atrioventricular block second degree","Bradycardia","Bundle branch block right","Cardiac failure congestive","Myocardial infarction","Palpitations","Sinus arrhythmia","Sinus bradycardia","Supraventricular extrasystoles","Ventricular extrasystoles","Wolff-parkinson-white syndrome","Ventricular septal defect","Tinnitus","Vertigo","Vision blurred","Abdominal pain","Diarrhoea","Dyspepsia","Gastrooesophageal reflux disease","Nausea","Vomiting","Application site bleeding","Application site dermatitis","Application site desquamation","Application site discolouration","Application site erythema","Application site induration","Application site irritation","Application site pruritus","Application site reaction","Application site swelling","Application site urticaria","Application site vesicles","Application site warmth","Asthenia","Chills","Fatigue","Malaise","Oedema","Pain","Fall","Skin laceration","Wound","Blood creatine phosphokinase increased","Body temperature increased","Electrocardiogram st segment depression","Heart rate increased","Heart rate irregular","Decreased appetite","Food craving","Increased appetite","Shoulder pain","Balance disorder","Complex partial seizures","Coordination 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See the\n * GNU General Public License for more details.\n *\n * You should have received a copy of the GNU General Public License\n * along with this program.  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TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","Surgical and medical procedures","SURGICAL AND MEDICAL PROCEDURES","SURGICAL AND MEDICAL PROCEDURES","Vascular disorders","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","Cardiac disorders","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","Congenital, familial and genetic disorders","CONGENITAL, FAMILIAL AND GENETIC DISORDERS","Ear and labyrinth disorders","EAR AND LABYRINTH DISORDERS","EAR AND LABYRINTH DISORDERS","Eye disorders","EYE DISORDERS","Gastrointestinal disorders","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","General disorders and administration site conditions","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","Injury, poisoning and procedural complications","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","Investigations","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","Metabolism and nutrition disorders","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","Musculoskeletal and connective tissue disorders","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","Nervous system disorders","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","Psychiatric disorders","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","Renal and urinary disorders","RENAL AND URINARY DISORDERS","Reproductive system and breast disorders","REPRODUCTIVE SYSTEM AND BREAST DISORDERS","Respiratory, thoracic and mediastinal disorders","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","Skin and subcutaneous tissue disorders","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","Vascular disorders","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","Nervous system disorders","NERVOUS SYSTEM 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See the\n * GNU General Public License for more details.\n *\n * You should have received a copy of the GNU General Public License\n * along with this program.  If not, see <http://www.gnu.org/licenses/>.\n *\n */\n\nfunction(cell, state) {\n  const Plot = createPlotlyComponent(Plotly);\n  var x = [cell.row[\"diff_1\"]];\n  var y = [1];\n  var x_lower = [cell.row[\"lower_1\"]];\n  var x_upper = [cell.row[\"upper_1\"]];\n  var x_range = [-20, 47];\n  var y_range = [0, 2];\n  var vline = [];\n  var text = [x[0] + '(' + x_lower[0] + ', ' + x_upper[0] + ')'];\n  var height = 30;\n  var width = 320;\n  var color = [\"rgba(0, 133, 124, 1)\"];\n  var color_errorbar = [\"rgba(0, 133, 124, 1)\"];\n  var color_vline = \"rgba(0, 0, 0, 0.313725490196078)\";\n  var margin = [0, 20, 0, 0, 0];\n  var x_label = \"\";\n  var showlegend = false;\n  var legend_title = \"\";\n  var legend_position = 0;\n  var legend_label = [\"\"];\n\n  return React.createElement(Plot, {\n    data: [\n      \n  {\n    \"x\": [x[0]],\n    \"y\": [y[0]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[0] - x[0]],\n      arrayminus: [x[0] - x_lower[0]],\n      \"color\": color_errorbar[0]\n    },\n    \"text\": text[0],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[0],\n    \"marker\": {\n      \"color\": [color[0]],\n      \"line\": {\n          \"color\": color[0]\n      }\n    },\n    \"line\": {\n        \"color\": color[0]\n    }\n  }\n    ],\n    \"layout\": {\n      \"height\": height,\n      \"width\": width,\n      \"margin\": {\n        \"b\": margin[0],\n        \"l\": margin[1],\n        \"t\": margin[2],\n        \"r\": margin[3],\n        \"pad\": margin[4]\n      },\n      \"xaxis\": {\n        \"domain\": [0,1],\n        \"title\": {\n          \"text\": x_label,\n          \"standoff\": 0,\n          \"font\": {\n            \"size\": 12\n          }\n        },\n        \"range\": x_range,\n        \"showline\": true,\n        \"ticks\": \"outside\",\n        \"zeroline\": false,\n        \"fixedrange\": true\n      },\n      \"yaxis\": {\n        \"domain\": [0,1],\n        \"title\": \"\",\n        \"range\": y_range,\n        \"showgrid\": false,\n        \"zeroline\": false,\n        \"showticklabels\": false,\n        \"fixedrange\": true\n      },\n      \"shapes\": [\n        {\n          \"type\": \"line\",\n          \"y0\": y_range[0],\n          \"y1\": y_range[1],\n          \"yref\": \"paper\",\n          \"x0\": vline,\n          \"x1\": vline,\n          \"line\": {\n            \"color\": color_vline\n          }\n        }\n      ],\n      \"plot_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"paper_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"hoverlabel\": {\n        \"bgcolor\": \"lightgray\"\n      },\n      \"showlegend\": showlegend,\n      \"hovermode\": \"closest\",\n      \"legend\": {\n        \"title\": {\n          \"text\": legend_title\n        },\n        \"orientation\": \"h\",\n        \"xanchor\": \"center\",\n        \"x\": 0.5,\n        \"y\": legend_position\n      }\n    },\n    \"config\": {\n      \"showSendToCloud\": false,\n      \"displayModeBar\": false\n    }\n  })\n}","footer":"/*\n * Copyright (c) 2023 Merck & Co., Inc., Rahway, NJ, USA and its affiliates.\n * All rights reserved.\n *\n * This file is part of the forestly program.\n *\n * forestly is free software: you can redistribute it and/or modify\n * it under the terms of the GNU General Public License as published by\n * the Free Software Foundation, either version 3 of the License, or\n * (at your option) any later version.\n *\n * This program is distributed in the hope that it will be useful,\n * but WITHOUT ANY WARRANTY; without even the implied warranty of\n * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the\n * GNU General Public License for more details.\n *\n * You should have received a copy of the GNU General Public License\n * along with this program.  If not, see <http://www.gnu.org/licenses/>.\n *\n */\n\nfunction(cell, state) {\n  const Plot = createPlotlyComponent(Plotly);\n  var x = [1];\n  var y = [-1];\n  var x_lower = [0];\n  var x_upper = [0];\n  var x_range = [-20, 47];\n  var y_range = [0, 2];\n  var vline = [];\n  var text = [\"\"];\n  var height = 90;\n  var width = 320;\n  var color = [\"rgba(255, 215, 0, 1)\"];\n  var color_errorbar = [\"rgba(255, 255, 255, 0)\"];\n  var color_vline = \"rgba(0, 0, 0, 0.313725490196078)\";\n  var margin = [70, 20, 0, 0, 0];\n  var x_label = \"Treatment <- Favor -> Placebo\";\n  var showlegend = false;\n  var legend_title = \"\";\n  var legend_position = 0;\n  var legend_label = [\"\"];\n\n  return React.createElement(Plot, {\n    data: [\n      \n  {\n    \"x\": [x[0]],\n    \"y\": [y[0]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[0] - x[0]],\n      arrayminus: [x[0] - x_lower[0]],\n      \"color\": color_errorbar[0]\n    },\n    \"text\": 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\"yaxis\": {\n        \"domain\": [0,1],\n        \"title\": \"\",\n        \"range\": y_range,\n        \"showgrid\": false,\n        \"zeroline\": false,\n        \"showticklabels\": false,\n        \"fixedrange\": true\n      },\n      \"shapes\": [\n        {\n          \"type\": \"line\",\n          \"y0\": y_range[0],\n          \"y1\": y_range[1],\n          \"yref\": \"paper\",\n          \"x0\": vline,\n          \"x1\": vline,\n          \"line\": {\n            \"color\": color_vline\n          }\n        }\n      ],\n      \"plot_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"paper_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"hoverlabel\": {\n        \"bgcolor\": \"lightgray\"\n      },\n      \"showlegend\": showlegend,\n      \"hovermode\": \"closest\",\n      \"legend\": {\n        \"title\": {\n          \"text\": legend_title\n        },\n        \"orientation\": \"h\",\n        \"xanchor\": \"center\",\n        \"x\": 0.5,\n        \"y\": legend_position\n      }\n    },\n    \"config\": {\n      \"showSendToCloud\": false,\n      \"displayModeBar\": false\n    }\n  })\n}","html":true,"width":320,"align":"center","style":{"font-size":"0px","padding":"0px","margin":"0px"},"footerStyle":{"font-size":"0px","padding":"0px","margin":"0px"},"show":true},{"id":"n_1","name":"n_1","type":"numeric","header":"n","defaultSortDesc":true,"minWidth":40,"align":"center","show":true},{"id":"n_2","name":"n_2","type":"numeric","header":"n","defaultSortDesc":true,"minWidth":40,"align":"center","show":true},{"id":"prop_1","name":"prop_1","type":"numeric","header":"(%)","defaultSortDesc":true,"format":{"cell":{"prefix":"(","suffix":")","digits":1},"aggregated":{"prefix":"(","suffix":")","digits":1}},"minWidth":60,"align":"center","show":true},{"id":"prop_2","name":"prop_2","type":"numeric","header":"(%)","defaultSortDesc":true,"format":{"cell":{"prefix":"(","suffix":")","digits":1},"aggregated":{"prefix":"(","suffix":")","digits":1}},"minWidth":60,"align":"center","show":true},{"id":"diff_1","name":"diff_1","type":"numeric","header":"Low 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@@ -665,20 +677,20 @@ <h2 id="define-metadata">Define metadata<a class="anchor" aria-label="anchor" hr
 <div class="container-fluid crosstalk-bscols">
 <div class="row">
 <div class="col-xs-3">
-<div id="filter_ae_3372|any adverse events" class="form-group crosstalk-input-select crosstalk-input">
-<label class="control-label" for="filter_ae_3372|any adverse events">AE Criteria</label>
+<div id="filter_ae_7823f6e3-2844-44b3-9743-728ae73be269|any adverse events" class="form-group crosstalk-input-select crosstalk-input">
+<label class="control-label" for="filter_ae_7823f6e3-2844-44b3-9743-728ae73be269|any adverse events">AE Criteria</label>
 <div>
-<select></select><script type="application/json" data-for="filter_ae_3372|any adverse events">{
+<select></select><script type="application/json" data-for="filter_ae_7823f6e3-2844-44b3-9743-728ae73be269|any adverse events">{
   "items": {
     "value": ["any adverse events", "drug-related adverse events", "serious adverse events"],
     "label": ["any adverse events", "drug-related adverse events", "serious adverse events"]
   },
   "map": {
-    "any adverse events": ["1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104", "105", "106", "107", "108", "109", "110", "111", "112", "113", "114", "115", "116", "117", "118", "119", "120", "121", "122", "123", "124", "125", "126", "127", "128", "129", "130", "131", "132", "133", "134", "135", "136", "137", "138", "139", "140", "141", "142", "143", "144", "145", "146", "147", "148", "149", "150", "151", "152", "153", "154", "155", "156", "157", "158", "159", "160", "161", "162", "163", "164", "165", "166", "167", "168", "169", "170", "171", "172", "173", "174", "175", "176", "177", "178", "179", "180"],
-    "drug-related adverse events": ["181", "182", "183", "184", "185", "186", "187", "188", "189", "190", "191", "192", "193", "194", "195", "196", "197", "198", "199", "200", "201", "202", "203", "204", "205", "206", "207", "208", "209", "210", "211", "212", "213", "214", "215", "216", "217", "218", "219", "220", "221", "222", "223", "224", "225", "226", "227", "228", "229", "230", "231", "232", "233", "234", "235", "236", "237", "238", "239", "240", "241", "242", "243", "244", "245", "246", "247", "248", "249", "250", "251", "252", "253", "254", "255", "256", "257", "258", "259", "260", "261", "262", "263", "264", "265", "266", "267", "268", "269", "270", "271"],
-    "serious adverse events": ["272"]
+    "any adverse events": ["1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104", "105", "106", "107", "108", "109", "110", "111", "112", "113", "114", "115", "116", "117", "118", "119", "120", "121", "122", "123", "124", "125", "126", "127", "128", "129", "130", "131", "132", "133", "134", "135", "136", "137", "138", "139", "140", "141", "142", "143", "144", "145", "146", "147", "148", "149", "150", "151", "152", "153", "154", "155", "156", "157", "158", "159", "160", "161", "162", "163", "164", "165", "166", "167", "168", "169", "170", "171", "172", "173", "174", "175", "176", "177", "178", "179", "180", "181", "182", "183", "184", "185", "186", "187", "188", "189", "190", "191", "192", "193", "194", "195", "196", "197", "198", "199", "200", "201", "202"],
+    "drug-related adverse events": ["203", "204", "205", "206", "207", "208", "209", "210", "211", "212", "213", "214", "215", "216", "217", "218", "219", "220", "221", "222", "223", "224", "225", "226", "227", "228", "229", "230", "231", "232", "233", "234", "235", "236", "237", "238", "239", "240", "241", "242", "243", "244", "245", "246", "247", "248", "249", "250", "251", "252", "253", "254", "255", "256", "257", "258", "259", "260", "261", "262", "263", "264", "265", "266", "267", "268", "269", "270", "271", "272", "273", "274", "275", "276", "277", "278", "279", "280", "281", "282", "283", "284", "285", "286", "287", "288", "289", "290", "291", "292", "293", "294", "295", "296", "297", "298", "299", "300", "301", "302", "303", "304", "305", "306", "307", "308", "309"],
+    "serious adverse events": ["310", "311"]
   },
-  "group": ["SharedDataaa3d2a04"]
+  "group": ["SharedData4e4c81bd"]
 }</script>
 </div>
 </div>
@@ -686,17 +698,20 @@ <h2 id="define-metadata">Define metadata<a class="anchor" aria-label="anchor" hr
 <div class="col-xs-9">
 <div class="form-group crosstalk-input crosstalk-input-slider js-range-slider" id="filter_subject" style="width: 250px;">
 <label class="control-label" for="filter_subject">Incidence (%) in One or More Treatment Groups</label>
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infection","Nasopharyngitis","Pneumonia","Upper respiratory tract infection","Urinary tract infection","Vaginal mycosis","Viral infection","Injury, poisoning and procedural complications","Contusion","Excoriation","Fall","Hip fracture","Joint dislocation","Skin laceration","Wound","Investigations","Blood alkaline phosphatase increased","Blood creatine phosphokinase increased","Blood glucose increased","Blood urine present","Body temperature increased","Cystoscopy","Electrocardiogram st segment depression","Electrocardiogram t wave amplitude decreased","Electrocardiogram t wave inversion","Heart rate increased","Heart rate irregular","Nasal mucosa biopsy","Metabolism and nutrition disorders","Decreased appetite","Dehydration","Diabetes mellitus","Food craving","Hyponatraemia","Increased appetite","Musculoskeletal and connective tissue disorders","Arthralgia","Back pain","Muscle spasms","Muscular weakness","Pain in extremity","Shoulder pain","Neoplasms benign, malignant and unspecified (incl cysts and polyps)","Colon cancer","Malignant fibrous histiocytoma","Nervous system disorders","Balance disorder","Complex partial seizures","Coordination abnormal","Dizziness","Headache","Hemianopia homonymous","Lethargy","Paraesthesia oral","Parkinson's disease","Psychomotor hyperactivity","Somnolence","Stupor","Syncope","Transient ischaemic attack","Psychiatric disorders","Agitation","Anxiety","Completed suicide","Confusional state","Delusion","Depressed mood","Disorientation","Insomnia","Irritability","Restlessness","Renal and urinary disorders","Dysuria","Incontinence","Micturition urgency","Nephrolithiasis","Pollakiuria","Reproductive system and breast disorders","Benign prostatic hyperplasia","Pelvic pain","Respiratory, thoracic and mediastinal disorders","Cough","Dysphonia","Dyspnoea","Emphysema","Epistaxis","Haemoptysis","Nasal congestion","Pharyngolaryngeal pain","Postnasal drip","Rales","Rhinorrhoea","Skin and subcutaneous tissue disorders","Alopecia","Blister","Cold sweat","Dermatitis contact","Drug eruption","Erythema","Hyperhidrosis","Pruritus","Pruritus generalised","Rash","Rash erythematous","Rash pruritic","Skin exfoliation","Skin irritation","Skin ulcer","Urticaria","Surgical and medical procedures","Cataract operation","Eye laser surgery","Vascular disorders","Hot flush","Hypertension","Hypotension","Orthostatic hypotension","Cardiac disorders","Atrial fibrillation","Atrial flutter","Atrioventricular block first degree","Atrioventricular block second degree","Bradycardia","Bundle branch block right","Cardiac failure congestive","Myocardial infarction","Palpitations","Sinus arrhythmia","Sinus bradycardia","Supraventricular extrasystoles","Ventricular extrasystoles","Wolff-parkinson-white syndrome","Congenital, familial and genetic disorders","Ventricular septal defect","Ear and labyrinth disorders","Vertigo","Eye disorders","Vision blurred","Gastrointestinal disorders","Abdominal pain","Diarrhoea","Dyspepsia","Gastrooesophageal reflux disease","Nausea","Vomiting","General disorders and administration site conditions","Application site bleeding","Application site dermatitis","Application site desquamation","Application site discolouration","Application site erythema","Application site induration","Application site irritation","Application site pruritus","Application site reaction","Application site swelling","Application site urticaria","Application site vesicles","Application site warmth","Asthenia","Chills","Fatigue","Malaise","Oedema","Pain","Injury, poisoning and procedural complications","Fall","Skin laceration","Wound","Investigations","Blood creatine phosphokinase increased","Body temperature increased","Electrocardiogram st segment depression","Heart rate increased","Heart rate irregular","Metabolism and nutrition disorders","Decreased appetite","Food craving","Increased appetite","Musculoskeletal and connective tissue disorders","Shoulder pain","Nervous system disorders","Balance disorder","Complex partial seizures","Coordination abnormal","Dizziness","Headache","Lethargy","Paraesthesia oral","Somnolence","Stupor","Syncope","Transient ischaemic attack","Psychiatric disorders","Agitation","Anxiety","Confusional state","Depressed mood","Irritability","Restlessness","Reproductive system and breast disorders","Pelvic pain","Respiratory, thoracic and mediastinal disorders","Dyspnoea","Emphysema","Skin and subcutaneous tissue disorders","Blister","Cold sweat","Dermatitis contact","Erythema","Hyperhidrosis","Pruritus","Pruritus generalised","Rash","Rash erythematous","Rash pruritic","Skin exfoliation","Skin irritation","Skin ulcer","Urticaria","Vascular disorders","Hypertension","Hypotension","Orthostatic hypotension","Nervous system disorders","Syncope"],"soc_name":["Cardiac disorders","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","Congenital, familial and genetic disorders","CONGENITAL, FAMILIAL AND GENETIC DISORDERS","Ear and labyrinth disorders","EAR AND LABYRINTH DISORDERS","EAR AND LABYRINTH DISORDERS","EAR AND LABYRINTH DISORDERS","Eye disorders","EYE DISORDERS","EYE DISORDERS","EYE DISORDERS","EYE DISORDERS","EYE DISORDERS","EYE DISORDERS","Gastrointestinal disorders","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","General disorders and administration site conditions","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","Hepatobiliary disorders","HEPATOBILIARY DISORDERS","Immune system disorders","IMMUNE SYSTEM DISORDERS","Infections and infestations","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","Injury, poisoning and procedural complications","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","Investigations","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","Metabolism and nutrition disorders","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","Musculoskeletal and connective tissue disorders","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","Neoplasms benign, malignant and unspecified (incl cysts and polyps)","NEOPLASMS BENIGN, MALIGNANT AND UNSPECIFIED (INCL CYSTS AND POLYPS)","NEOPLASMS BENIGN, MALIGNANT AND UNSPECIFIED (INCL CYSTS AND POLYPS)","Nervous system disorders","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","Psychiatric disorders","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","Renal and urinary disorders","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","Reproductive system and breast disorders","REPRODUCTIVE SYSTEM AND BREAST DISORDERS","REPRODUCTIVE SYSTEM AND BREAST DISORDERS","Respiratory, thoracic and mediastinal disorders","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","Skin and subcutaneous tissue disorders","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","Surgical and medical procedures","SURGICAL AND MEDICAL PROCEDURES","SURGICAL AND MEDICAL PROCEDURES","Vascular disorders","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","Cardiac disorders","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","Congenital, familial and genetic disorders","CONGENITAL, FAMILIAL AND GENETIC DISORDERS","Ear and labyrinth disorders","EAR AND LABYRINTH DISORDERS","Eye disorders","EYE DISORDERS","Gastrointestinal disorders","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","General disorders and administration site conditions","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","Injury, poisoning and procedural complications","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","Investigations","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","Metabolism and nutrition disorders","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","Musculoskeletal and connective tissue disorders","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","Nervous system disorders","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","Psychiatric disorders","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","Reproductive system and breast disorders","REPRODUCTIVE SYSTEM AND BREAST DISORDERS","Respiratory, thoracic and mediastinal disorders","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","Skin and subcutaneous tissue disorders","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","Vascular disorders","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","Nervous system disorders","NERVOUS SYSTEM 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See the\n * GNU General Public License for more details.\n *\n * You should have received a copy of the GNU General Public License\n * along with this program.  If not, see <http://www.gnu.org/licenses/>.\n *\n */\n\nfunction(cell, state) {\n  const Plot = createPlotlyComponent(Plotly);\n  var x = [1, 2];\n  var y = [-1, -1];\n  var x_lower = [0];\n  var x_upper = [0];\n  var x_range = [-2, 58];\n  var y_range = [0, 3];\n  var vline = [];\n  var text = [\"\", \"\"];\n  var height = 90;\n  var width = 320;\n  var color = [\"rgba(0, 133, 124, 1)\", \"rgba(102, 32, 58, 1)\"];\n  var color_errorbar = [\"rgba(255, 255, 255, 0)\"];\n  var color_vline = \"rgba(0, 0, 0, 0.313725490196078)\";\n  var margin = [70, 0, 0, 0, 0];\n  var x_label = \"\";\n  var showlegend = true;\n  var legend_title = \"\";\n  var legend_position = -0.8;\n  var legend_label = [\"Low Dose\", \"Placebo\"];\n\n  return React.createElement(Plot, {\n    data: [\n      \n  {\n    \"x\": [x[0]],\n    \"y\": [y[0]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[0] - x[0]],\n      arrayminus: [x[0] - x_lower[0]],\n      \"color\": color_errorbar[0]\n    },\n    \"text\": text[0],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[0],\n    \"marker\": {\n      \"color\": [color[0]],\n      \"line\": {\n          \"color\": color[0]\n      }\n    },\n    \"line\": {\n        \"color\": color[0]\n    }\n  },\n  {\n    \"x\": [x[1]],\n    \"y\": [y[1]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[1] - x[1]],\n      arrayminus: [x[1] - x_lower[1]],\n      \"color\": color_errorbar[1]\n    },\n    \"text\": text[1],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[1],\n    \"marker\": {\n      \"color\": [color[1]],\n      \"line\": {\n          \"color\": color[1]\n      }\n    },\n    \"line\": {\n        \"color\": color[1]\n    }\n  }\n    ],\n    \"layout\": {\n      \"height\": height,\n      \"width\": width,\n      \"margin\": {\n        \"b\": margin[0],\n        \"l\": margin[1],\n        \"t\": margin[2],\n        \"r\": margin[3],\n        \"pad\": margin[4]\n      },\n      \"xaxis\": {\n        \"domain\": [0,1],\n        \"title\": {\n          \"text\": x_label,\n          \"standoff\": 0,\n          \"font\": {\n            \"size\": 12\n          }\n        },\n        \"range\": x_range,\n        \"showline\": true,\n        \"ticks\": \"outside\",\n        \"zeroline\": false,\n        \"fixedrange\": true\n      },\n      \"yaxis\": {\n        \"domain\": [0,1],\n        \"title\": \"\",\n        \"range\": y_range,\n        \"showgrid\": false,\n        \"zeroline\": false,\n        \"showticklabels\": false,\n        \"fixedrange\": true\n      },\n      \"shapes\": [\n        {\n          \"type\": \"line\",\n          \"y0\": y_range[0],\n          \"y1\": y_range[1],\n          \"yref\": \"paper\",\n          \"x0\": vline,\n          \"x1\": vline,\n          \"line\": {\n            \"color\": color_vline\n          }\n        }\n      ],\n      \"plot_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"paper_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"hoverlabel\": {\n        \"bgcolor\": \"lightgray\"\n      },\n      \"showlegend\": showlegend,\n      \"hovermode\": \"closest\",\n      \"legend\": {\n        \"title\": {\n          \"text\": legend_title\n        },\n        \"orientation\": \"h\",\n        \"xanchor\": \"center\",\n        \"x\": 0.5,\n        \"y\": legend_position\n      }\n    },\n    \"config\": {\n      \"showSendToCloud\": false,\n      \"displayModeBar\": false\n    }\n  })\n}","html":true,"width":320,"align":"center","style":{"font-size":"0px","padding":"0px","margin":"0px"},"footerStyle":{"font-size":"0px","padding":"0px","margin":"0px"},"show":true},{"id":"diff_fig","name":"diff_fig","type":"logical","header":"Risk Difference (%) + 95% CI <br> vs. Placebo","defaultSortDesc":true,"cell":"/*\n * Copyright (c) 2023 Merck & Co., Inc., Rahway, NJ, USA and its affiliates.\n * All rights reserved.\n *\n * This file is part of the forestly program.\n *\n * forestly is free software: you can redistribute it and/or modify\n * it under the terms of the GNU General Public License as published by\n * the Free Software Foundation, either version 3 of the License, or\n * (at your option) any later version.\n *\n * This program is distributed in the hope that it will be useful,\n * but WITHOUT ANY WARRANTY; without even the implied warranty of\n * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the\n * GNU General Public License for more details.\n *\n * You should have received a copy of the GNU General Public License\n * along with this program.  If not, see <http://www.gnu.org/licenses/>.\n *\n */\n\nfunction(cell, state) {\n  const Plot = createPlotlyComponent(Plotly);\n  var x = [cell.row[\"diff_1\"]];\n  var y = [1];\n  var x_lower = [cell.row[\"lower_1\"]];\n  var x_upper = [cell.row[\"upper_1\"]];\n  var x_range = [-21, 47];\n  var y_range = [0, 2];\n  var vline = [];\n  var text = [x[0] + '(' + x_lower[0] + ', ' + x_upper[0] + ')'];\n  var height = 30;\n  var width = 320;\n  var color = [\"rgba(0, 133, 124, 1)\"];\n  var color_errorbar = [\"rgba(0, 133, 124, 1)\"];\n  var color_vline = \"rgba(0, 0, 0, 0.313725490196078)\";\n  var margin = [0, 20, 0, 0, 0];\n  var x_label = \"\";\n  var showlegend = false;\n  var legend_title = \"\";\n  var legend_position = 0;\n  var legend_label = [\"\"];\n\n  return React.createElement(Plot, {\n    data: [\n      \n  {\n    \"x\": [x[0]],\n    \"y\": [y[0]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[0] - x[0]],\n      arrayminus: [x[0] - x_lower[0]],\n      \"color\": color_errorbar[0]\n    },\n    \"text\": text[0],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[0],\n    \"marker\": {\n      \"color\": [color[0]],\n      \"line\": {\n          \"color\": color[0]\n      }\n    },\n    \"line\": {\n        \"color\": color[0]\n    }\n  }\n    ],\n    \"layout\": {\n      \"height\": height,\n      \"width\": width,\n      \"margin\": {\n        \"b\": margin[0],\n        \"l\": margin[1],\n        \"t\": margin[2],\n        \"r\": margin[3],\n        \"pad\": margin[4]\n      },\n      \"xaxis\": {\n        \"domain\": [0,1],\n        \"title\": {\n          \"text\": x_label,\n          \"standoff\": 0,\n          \"font\": {\n            \"size\": 12\n          }\n        },\n        \"range\": x_range,\n        \"showline\": true,\n        \"ticks\": \"outside\",\n        \"zeroline\": false,\n        \"fixedrange\": true\n      },\n      \"yaxis\": {\n        \"domain\": [0,1],\n        \"title\": \"\",\n        \"range\": y_range,\n        \"showgrid\": false,\n        \"zeroline\": false,\n        \"showticklabels\": false,\n        \"fixedrange\": true\n      },\n      \"shapes\": [\n        {\n          \"type\": \"line\",\n          \"y0\": y_range[0],\n          \"y1\": y_range[1],\n          \"yref\": \"paper\",\n          \"x0\": vline,\n          \"x1\": vline,\n          \"line\": {\n            \"color\": color_vline\n          }\n        }\n      ],\n      \"plot_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"paper_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"hoverlabel\": {\n        \"bgcolor\": \"lightgray\"\n      },\n      \"showlegend\": showlegend,\n      \"hovermode\": \"closest\",\n      \"legend\": {\n        \"title\": {\n          \"text\": legend_title\n        },\n        \"orientation\": \"h\",\n        \"xanchor\": \"center\",\n        \"x\": 0.5,\n        \"y\": legend_position\n      }\n    },\n    \"config\": {\n      \"showSendToCloud\": false,\n      \"displayModeBar\": false\n    }\n  })\n}","footer":"/*\n * Copyright (c) 2023 Merck & Co., Inc., Rahway, NJ, USA and its affiliates.\n * All rights reserved.\n *\n * This file is part of the forestly program.\n *\n * forestly is free software: you can redistribute it and/or modify\n * it under the terms of the GNU General Public License as published by\n * the Free Software Foundation, either version 3 of the License, or\n * (at your option) any later version.\n *\n * This program is distributed in the hope that it will be useful,\n * but WITHOUT ANY WARRANTY; without even the implied warranty of\n * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the\n * GNU General Public License for more details.\n *\n * You should have received a copy of the GNU General Public License\n * along with this program.  If not, see <http://www.gnu.org/licenses/>.\n *\n */\n\nfunction(cell, state) {\n  const Plot = createPlotlyComponent(Plotly);\n  var x = [1];\n  var y = [-1];\n  var x_lower = [0];\n  var x_upper = [0];\n  var x_range = [-21, 47];\n  var y_range = [0, 2];\n  var vline = [];\n  var text = [\"\"];\n  var height = 90;\n  var width = 320;\n  var color = [\"rgba(255, 215, 0, 1)\"];\n  var color_errorbar = [\"rgba(255, 255, 255, 0)\"];\n  var color_vline = \"rgba(0, 0, 0, 0.313725490196078)\";\n  var margin = [70, 20, 0, 0, 0];\n  var x_label = \"Treatment <- Favor -> Placebo\";\n  var showlegend = false;\n  var legend_title = \"\";\n  var legend_position = 0;\n  var legend_label = [\"\"];\n\n  return React.createElement(Plot, {\n    data: [\n      \n  {\n    \"x\": [x[0]],\n    \"y\": [y[0]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[0] - x[0]],\n      arrayminus: [x[0] - x_lower[0]],\n      \"color\": color_errorbar[0]\n    },\n    \"text\": text[0],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[0],\n    \"marker\": {\n      \"color\": [color[0]],\n      \"line\": {\n          \"color\": color[0]\n      }\n    },\n    \"line\": {\n        \"color\": color[0]\n    }\n  }\n    ],\n    \"layout\": {\n      \"height\": height,\n      \"width\": width,\n      \"margin\": {\n        \"b\": margin[0],\n        \"l\": margin[1],\n        \"t\": margin[2],\n        \"r\": margin[3],\n        \"pad\": margin[4]\n      },\n      \"xaxis\": {\n        \"domain\": [0,1],\n        \"title\": {\n          \"text\": x_label,\n          \"standoff\": 0,\n          \"font\": {\n            \"size\": 12\n          }\n        },\n        \"range\": x_range,\n        \"showline\": true,\n        \"ticks\": \"outside\",\n        \"zeroline\": false,\n        \"fixedrange\": true\n      },\n      \"yaxis\": {\n        \"domain\": [0,1],\n        \"title\": \"\",\n        \"range\": y_range,\n        \"showgrid\": false,\n        \"zeroline\": false,\n        \"showticklabels\": false,\n        \"fixedrange\": true\n      },\n      \"shapes\": [\n        {\n          \"type\": \"line\",\n          \"y0\": y_range[0],\n          \"y1\": y_range[1],\n          \"yref\": \"paper\",\n          \"x0\": vline,\n          \"x1\": vline,\n          \"line\": {\n            \"color\": color_vline\n          }\n        }\n      ],\n      \"plot_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"paper_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"hoverlabel\": {\n        \"bgcolor\": \"lightgray\"\n      },\n      \"showlegend\": showlegend,\n      \"hovermode\": \"closest\",\n      \"legend\": {\n        \"title\": {\n          \"text\": legend_title\n        },\n        \"orientation\": \"h\",\n        \"xanchor\": \"center\",\n        \"x\": 0.5,\n        \"y\": legend_position\n      }\n    },\n    \"config\": {\n      \"showSendToCloud\": false,\n      \"displayModeBar\": false\n    }\n  })\n}","html":true,"width":320,"align":"center","style":{"font-size":"0px","padding":"0px","margin":"0px"},"footerStyle":{"font-size":"0px","padding":"0px","margin":"0px"},"show":true},{"id":"n_1","name":"n_1","type":"numeric","header":"n","defaultSortDesc":true,"minWidth":40,"align":"center","show":true},{"id":"n_2","name":"n_2","type":"numeric","header":"n","defaultSortDesc":true,"minWidth":40,"align":"center","show":true},{"id":"prop_1","name":"prop_1","type":"numeric","header":"(%)","defaultSortDesc":true,"format":{"cell":{"prefix":"(","suffix":")","digits":1},"aggregated":{"prefix":"(","suffix":")","digits":1}},"minWidth":60,"align":"center","show":true},{"id":"prop_2","name":"prop_2","type":"numeric","header":"(%)","defaultSortDesc":true,"format":{"cell":{"prefix":"(","suffix":")","digits":1},"aggregated":{"prefix":"(","suffix":")","digits":1}},"minWidth":60,"align":"center","show":true},{"id":"diff_1","name":"diff_1","type":"numeric","header":"Low 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diff --git a/articles/layout.html b/articles/layout.html
index 62fcfc4..3a1148f 100644
--- a/articles/layout.html
+++ b/articles/layout.html
@@ -125,23 +125,24 @@ <h2 id="overview">Overview<a class="anchor" aria-label="anchor" href="#overview"
 <span><span class="va">outdata</span> <span class="op">&lt;-</span> <span class="va">metadata</span> <span class="op">|&gt;</span> <span class="fu"><a href="../reference/prepare_ae_forestly.html">prepare_ae_forestly</a></span><span class="op">(</span><span class="op">)</span></span>
 <span></span>
 <span><span class="va">outdata</span></span>
-<span><span class="co">#&gt; List of 17</span></span>
+<span><span class="co">#&gt; List of 18</span></span>
 <span><span class="co">#&gt;  $ meta           :List of 7</span></span>
 <span><span class="co">#&gt;  $ population     : chr "apat"</span></span>
 <span><span class="co">#&gt;  $ observation    : chr "safety"</span></span>
 <span><span class="co">#&gt;  $ parameter      : chr "any;rel;ser"</span></span>
-<span><span class="co">#&gt;  $ n              :'data.frame': 361 obs. of  4 variables:</span></span>
-<span><span class="co">#&gt;  $ order          : num [1:361] 1030 1031 1032 1033 1034 ...</span></span>
+<span><span class="co">#&gt;  $ n              :'data.frame': 402 obs. of  4 variables:</span></span>
+<span><span class="co">#&gt;  $ order          : num [1:402] 1000 1030 1031 1032 1033 ...</span></span>
 <span><span class="co">#&gt;  $ group          : chr [1:4] "Placebo" "Low Dose" "High Dose" "Total"</span></span>
 <span><span class="co">#&gt;  $ reference_group: num 1</span></span>
 <span><span class="co">#&gt;  $ parameter_order: Factor w/ 3 levels "any","rel","ser": 1 1 1 1 1 1 1 1 1 1 ...</span></span>
-<span><span class="co">#&gt;  $ prop           :'data.frame': 361 obs. of  4 variables:</span></span>
-<span><span class="co">#&gt;  $ diff           :'data.frame': 361 obs. of  2 variables:</span></span>
+<span><span class="co">#&gt;  $ prop           :'data.frame': 402 obs. of  4 variables:</span></span>
+<span><span class="co">#&gt;  $ diff           :'data.frame': 402 obs. of  2 variables:</span></span>
 <span><span class="co">#&gt;  $ n_pop          :'data.frame': 1 obs. of  4 variables:</span></span>
-<span><span class="co">#&gt;  $ name           : chr [1:361] "Atrial fibrillation" "Atrial flutter" "Atrial hypertrophy" "Atrioventricular block first degree" ...</span></span>
-<span><span class="co">#&gt;  $ ci_lower       :'data.frame': 361 obs. of  2 variables:</span></span>
-<span><span class="co">#&gt;  $ ci_upper       :'data.frame': 361 obs. of  2 variables:</span></span>
-<span><span class="co">#&gt;  $ p              :'data.frame': 361 obs. of  2 variables:</span></span>
+<span><span class="co">#&gt;  $ name           : chr [1:402] "Cardiac disorders" "Atrial fibrillation" "Atrial flutter" "Atrial hypertrophy" ...</span></span>
+<span><span class="co">#&gt;  $ soc_name       : chr [1:402] "Cardiac disorders" "CARDIAC DISORDERS" "CARDIAC DISORDERS" "CARDIAC DISORDERS" ...</span></span>
+<span><span class="co">#&gt;  $ ci_lower       :'data.frame': 402 obs. of  2 variables:</span></span>
+<span><span class="co">#&gt;  $ ci_upper       :'data.frame': 402 obs. of  2 variables:</span></span>
+<span><span class="co">#&gt;  $ p              :'data.frame': 402 obs. of  2 variables:</span></span>
 <span><span class="co">#&gt;  $ ae_listing     :'data.frame': 1898 obs. of  14 variables:</span></span></code></pre></div>
 <p>The interactive forest plot with default style can be generated.</p>
 <div class="sourceCode" id="cb3"><pre class="downlit sourceCode r">
@@ -151,18 +152,18 @@ <h2 id="overview">Overview<a class="anchor" aria-label="anchor" href="#overview"
 <div class="container-fluid crosstalk-bscols">
 <div class="row">
 <div class="col-xs-3">
-<div id="filter_ae_485|any adverse events" class="form-group crosstalk-input-select crosstalk-input">
-<label class="control-label" for="filter_ae_485|any adverse events">AE Criteria</label>
+<div id="filter_ae_ebde6e07-d1d7-4d47-b4bb-f30d6a965e8d|any adverse events" class="form-group crosstalk-input-select crosstalk-input">
+<label class="control-label" for="filter_ae_ebde6e07-d1d7-4d47-b4bb-f30d6a965e8d|any adverse events">AE Criteria</label>
 <div>
-<select></select><script type="application/json" data-for="filter_ae_485|any adverse events">{
+<select></select><script type="application/json" data-for="filter_ae_ebde6e07-d1d7-4d47-b4bb-f30d6a965e8d|any adverse events">{
   "items": {
     "value": ["any adverse events", "drug-related adverse events", "serious adverse events"],
     "label": ["any adverse events", "drug-related adverse events", "serious adverse events"]
   },
   "map": {
-    "any adverse events": ["1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104", "105", "106", "107", "108", "109", "110", "111", "112", "113", "114", "115", "116", "117", "118", "119", "120", "121", "122", "123", "124", "125", "126", "127", "128", "129", "130", "131", "132", "133", "134", "135", "136", "137", "138", "139", "140", "141", "142", "143", "144", "145", "146", "147", "148", "149", "150", "151", "152", "153", "154", "155", "156", "157", "158", "159", "160", "161", "162", "163", "164", "165", "166", "167", "168", "169", "170", "171", "172", "173", "174", "175", "176", "177", "178", "179", "180", "181", "182", "183", "184", "185", "186", "187", "188", "189", "190", "191", "192", "193", "194", "195", "196", "197", "198", "199", "200", "201", "202", "203", "204", "205", "206", "207", "208", "209", "210", "211", "212", "213", "214", "215", "216", "217", "218", "219", "220", "221", "222", "223", "224", "225", "226", "227", "228", "229", "230", "231", "232", "233", "234", "235", "236", "237", "238", "239", "240", "241", "242"],
-    "drug-related adverse events": ["243", "244", "245", "246", "247", "248", "249", "250", "251", "252", "253", "254", "255", "256", "257", "258", "259", "260", "261", "262", "263", "264", "265", "266", "267", "268", "269", "270", "271", "272", "273", "274", "275", "276", "277", "278", "279", "280", "281", "282", "283", "284", "285", "286", "287", "288", "289", "290", "291", "292", "293", "294", "295", "296", "297", "298", "299", "300", "301", "302", "303", "304", "305", "306", "307", "308", "309", "310", "311", "312", "313", "314", "315", "316", "317", "318", "319", "320", "321", "322", "323", "324", "325", "326", "327", "328", "329", "330", "331", "332", "333", "334", "335", "336", "337", "338", "339", "340", "341", "342", "343", "344", "345", "346", "347", "348", "349", "350", "351", "352", "353", "354", "355", "356", "357", "358", "359"],
-    "serious adverse events": ["360", "361"]
+    "any adverse events": ["1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104", "105", "106", "107", "108", "109", "110", "111", "112", "113", "114", "115", "116", "117", "118", "119", "120", "121", "122", "123", "124", "125", "126", "127", "128", "129", "130", "131", "132", "133", "134", "135", "136", "137", "138", "139", "140", "141", "142", "143", "144", "145", "146", "147", "148", "149", "150", "151", "152", "153", "154", "155", "156", "157", "158", "159", "160", "161", "162", "163", "164", "165", "166", "167", "168", "169", "170", "171", "172", "173", "174", "175", "176", "177", "178", "179", "180", "181", "182", "183", "184", "185", "186", "187", "188", "189", "190", "191", "192", "193", "194", "195", "196", "197", "198", "199", "200", "201", "202", "203", "204", "205", "206", "207", "208", "209", "210", "211", "212", "213", "214", "215", "216", "217", "218", "219", "220", "221", "222", "223", "224", "225", "226", "227", "228", "229", "230", "231", "232", "233", "234", "235", "236", "237", "238", "239", "240", "241", "242", "243", "244", "245", "246", "247", "248", "249", "250", "251", "252", "253", "254", "255", "256", "257", "258", "259", "260", "261", "262", "263", "264", "265"],
+    "drug-related adverse events": ["266", "267", "268", "269", "270", "271", "272", "273", "274", "275", "276", "277", "278", "279", "280", "281", "282", "283", "284", "285", "286", "287", "288", "289", "290", "291", "292", "293", "294", "295", "296", "297", "298", "299", "300", "301", "302", "303", "304", "305", "306", "307", "308", "309", "310", "311", "312", "313", "314", "315", "316", "317", "318", "319", "320", "321", "322", "323", "324", "325", "326", "327", "328", "329", "330", "331", "332", "333", "334", "335", "336", "337", "338", "339", "340", "341", "342", "343", "344", "345", "346", "347", "348", "349", "350", "351", "352", "353", "354", "355", "356", "357", "358", "359", "360", "361", "362", "363", "364", "365", "366", "367", "368", "369", "370", "371", "372", "373", "374", "375", "376", "377", "378", "379", "380", "381", "382", "383", "384", "385", "386", "387", "388", "389", "390", "391", "392", "393", "394", "395", "396", "397", "398", "399"],
+    "serious adverse events": ["400", "401", "402"]
   },
   "group": ["SharedDataac96cb3e"]
 }</script>
@@ -172,17 +173,20 @@ <h2 id="overview">Overview<a class="anchor" aria-label="anchor" href="#overview"
 <div class="col-xs-9">
 <div class="form-group crosstalk-input crosstalk-input-slider js-range-slider" id="filter_subject" style="width: 250px;">
 <label class="control-label" for="filter_subject">Incidence (%) in One or More Treatment Groups</label>
-<input data-skin="shiny" data-type="double" data-min="0" data-max="40" data-from="0" data-to="40" data-step="1" data-grid="true" data-grid-num="10" data-grid-snap="false" data-prettify-separator="," data-keyboard="true" data-keyboard-step="1" data-drag-interval="true" data-data-type="number"><script type="application/json" data-for="filter_subject">{
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DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","Congenital, familial and genetic disorders","CONGENITAL, FAMILIAL AND GENETIC DISORDERS","Ear and labyrinth disorders","EAR AND LABYRINTH DISORDERS","EAR AND LABYRINTH DISORDERS","EAR AND LABYRINTH DISORDERS","EAR AND LABYRINTH DISORDERS","Eye disorders","EYE DISORDERS","EYE DISORDERS","EYE DISORDERS","EYE DISORDERS","EYE DISORDERS","EYE DISORDERS","EYE DISORDERS","Gastrointestinal disorders","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","General disorders and administration site conditions","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","Hepatobiliary disorders","HEPATOBILIARY DISORDERS","Immune system disorders","IMMUNE SYSTEM DISORDERS","IMMUNE SYSTEM DISORDERS","Infections and infestations","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","Injury, poisoning and procedural complications","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","Investigations","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","Metabolism and nutrition disorders","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","Musculoskeletal and connective tissue disorders","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","Neoplasms benign, malignant and unspecified (incl cysts and polyps)","NEOPLASMS BENIGN, MALIGNANT AND UNSPECIFIED (INCL CYSTS AND POLYPS)","NEOPLASMS BENIGN, MALIGNANT AND UNSPECIFIED (INCL CYSTS AND POLYPS)","NEOPLASMS BENIGN, MALIGNANT AND UNSPECIFIED (INCL CYSTS AND POLYPS)","Nervous system disorders","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","Psychiatric disorders","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","Renal and urinary disorders","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","Reproductive system and breast disorders","REPRODUCTIVE SYSTEM AND BREAST DISORDERS","REPRODUCTIVE SYSTEM AND BREAST DISORDERS","Respiratory, thoracic and mediastinal disorders","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","Skin and subcutaneous tissue disorders","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","Social circumstances","SOCIAL CIRCUMSTANCES","Surgical and medical procedures","SURGICAL AND MEDICAL PROCEDURES","SURGICAL AND MEDICAL PROCEDURES","SURGICAL AND MEDICAL PROCEDURES","SURGICAL AND MEDICAL PROCEDURES","Vascular disorders","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","Cardiac disorders","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","Congenital, familial and genetic disorders","CONGENITAL, FAMILIAL AND GENETIC DISORDERS","Ear and labyrinth disorders","EAR AND LABYRINTH DISORDERS","EAR AND LABYRINTH DISORDERS","Eye disorders","EYE DISORDERS","Gastrointestinal disorders","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","General disorders and administration site conditions","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","Injury, poisoning and procedural complications","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","Investigations","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","Metabolism and nutrition disorders","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","Musculoskeletal and connective tissue disorders","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","Nervous system disorders","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","Psychiatric disorders","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","Renal and urinary disorders","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","Reproductive system and breast disorders","REPRODUCTIVE SYSTEM AND BREAST DISORDERS","Respiratory, thoracic and mediastinal disorders","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","Skin and subcutaneous tissue disorders","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","Vascular disorders","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","Nervous system disorders","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM 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If not, see <http://www.gnu.org/licenses/>.\n *\n */\n\nfunction(cell, state) {\n  const Plot = createPlotlyComponent(Plotly);\n  var x = [cell.row[\"prop_1\"], cell.row[\"prop_2\"], cell.row[\"prop_3\"]];\n  var y = [1.5, 1, 2];\n  var x_lower = [0];\n  var x_upper = [0];\n  var x_range = [-2, 58];\n  var y_range = [0, 4];\n  var vline = [];\n  var text = [x[0], x[1], x[2]];\n  var height = 30;\n  var width = 320;\n  var color = [\"rgba(102, 32, 58, 1)\", \"rgba(110, 206, 178, 1)\", \"rgba(0, 133, 124, 1)\"];\n  var color_errorbar = [\"rgba(255, 255, 255, 0)\"];\n  var color_vline = \"rgba(0, 0, 0, 0.313725490196078)\";\n  var margin = [0, 0, 0, 0, 0];\n  var x_label = \"\";\n  var showlegend = false;\n  var legend_title = \"\";\n  var legend_position = 0;\n  var legend_label = [\"\"];\n\n  return React.createElement(Plot, {\n    data: [\n      \n  {\n    \"x\": [x[0]],\n    \"y\": [y[0]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[0] - x[0]],\n      arrayminus: [x[0] - x_lower[0]],\n      \"color\": color_errorbar[0]\n    },\n    \"text\": text[0],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[0],\n    \"marker\": {\n      \"color\": [color[0]],\n      \"line\": {\n          \"color\": color[0]\n      }\n    },\n    \"line\": {\n        \"color\": color[0]\n    }\n  },\n  {\n    \"x\": [x[1]],\n    \"y\": [y[1]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[1] - x[1]],\n      arrayminus: [x[1] - x_lower[1]],\n      \"color\": color_errorbar[1]\n    },\n    \"text\": text[1],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[1],\n    \"marker\": {\n      \"color\": [color[1]],\n      \"line\": {\n          \"color\": color[1]\n      }\n    },\n    \"line\": {\n        \"color\": color[1]\n    }\n  },\n  {\n    \"x\": [x[2]],\n    \"y\": [y[2]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[2] - x[2]],\n      arrayminus: [x[2] - x_lower[2]],\n      \"color\": color_errorbar[2]\n    },\n    \"text\": text[2],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[2],\n    \"marker\": {\n      \"color\": [color[2]],\n      \"line\": {\n          \"color\": color[2]\n      }\n    },\n    \"line\": {\n        \"color\": color[2]\n    }\n  }\n    ],\n    \"layout\": {\n      \"height\": height,\n      \"width\": width,\n      \"margin\": {\n        \"b\": margin[0],\n        \"l\": margin[1],\n        \"t\": margin[2],\n        \"r\": margin[3],\n        \"pad\": margin[4]\n      },\n      \"xaxis\": {\n        \"domain\": [0,1],\n        \"title\": {\n          \"text\": x_label,\n          \"standoff\": 0,\n          \"font\": {\n            \"size\": 12\n          }\n        },\n        \"range\": x_range,\n        \"showline\": true,\n        \"ticks\": \"outside\",\n        \"zeroline\": false,\n        \"fixedrange\": true\n      },\n      \"yaxis\": {\n        \"domain\": [0,1],\n        \"title\": \"\",\n        \"range\": y_range,\n        \"showgrid\": false,\n        \"zeroline\": false,\n        \"showticklabels\": false,\n        \"fixedrange\": true\n      },\n      \"shapes\": [\n        {\n          \"type\": \"line\",\n          \"y0\": y_range[0],\n          \"y1\": y_range[1],\n          \"yref\": \"paper\",\n          \"x0\": vline,\n          \"x1\": vline,\n          \"line\": {\n            \"color\": color_vline\n          }\n        }\n      ],\n      \"plot_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"paper_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"hoverlabel\": {\n        \"bgcolor\": \"lightgray\"\n      },\n      \"showlegend\": showlegend,\n      \"hovermode\": \"closest\",\n      \"legend\": {\n        \"title\": {\n          \"text\": legend_title\n        },\n        \"orientation\": \"h\",\n        \"xanchor\": \"center\",\n        \"x\": 0.5,\n        \"y\": legend_position\n      }\n    },\n    \"config\": {\n      \"showSendToCloud\": false,\n      \"displayModeBar\": false\n    }\n  })\n}","footer":"/*\n * Copyright (c) 2023 Merck & Co., Inc., Rahway, NJ, USA and its affiliates.\n * All rights reserved.\n *\n * This file is part of the forestly program.\n *\n * forestly is free software: you can redistribute it and/or modify\n * it under the terms of the GNU General Public License as published by\n * the Free Software Foundation, either version 3 of the License, or\n * (at your option) any later version.\n *\n * This program is distributed in the hope that it will be useful,\n * but WITHOUT ANY WARRANTY; without even the implied warranty of\n * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the\n * GNU General Public License for more details.\n *\n * You should have received a copy of the GNU General Public License\n * along with this program.  If not, see <http://www.gnu.org/licenses/>.\n *\n */\n\nfunction(cell, state) {\n  const Plot = createPlotlyComponent(Plotly);\n  var x = [1, 2, 3];\n  var y = [-1, -1, -1];\n  var x_lower = [0];\n  var x_upper = [0];\n  var x_range = [-2, 58];\n  var y_range = [0, 4];\n  var vline = [];\n  var text = [\"\", \"\", \"\"];\n  var height = 90;\n  var width = 320;\n  var color = [\"rgba(102, 32, 58, 1)\", \"rgba(110, 206, 178, 1)\", \"rgba(0, 133, 124, 1)\"];\n  var color_errorbar = [\"rgba(255, 255, 255, 0)\"];\n  var color_vline = \"rgba(0, 0, 0, 0.313725490196078)\";\n  var margin = [70, 0, 0, 0, 0];\n  var x_label = \"\";\n  var showlegend = true;\n  var legend_title = \"\";\n  var legend_position = -0.8;\n  var legend_label = [\"Placebo\", \"Low Dose\", \"High Dose\"];\n\n  return React.createElement(Plot, {\n    data: [\n      \n  {\n    \"x\": [x[0]],\n    \"y\": [y[0]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[0] - x[0]],\n      arrayminus: [x[0] - 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See the\n * GNU General Public License for more details.\n *\n * You should have received a copy of the GNU General Public License\n * along with this program.  If not, see <http://www.gnu.org/licenses/>.\n *\n */\n\nfunction(cell, state) {\n  const Plot = createPlotlyComponent(Plotly);\n  var x = [cell.row[\"diff_2\"], cell.row[\"diff_3\"]];\n  var y = [1, 2];\n  var x_lower = [cell.row[\"lower_2\"], cell.row[\"lower_3\"]];\n  var x_upper = [cell.row[\"upper_2\"], cell.row[\"upper_3\"]];\n  var x_range = [-20, 47];\n  var y_range = [0, 3];\n  var vline = [];\n  var text = [x[0] + '(' + x_lower[0] + ', ' + x_upper[0] + ')', x[1] + '(' + x_lower[1] + ', ' + x_upper[1] + ')'];\n  var height = 30;\n  var width = 320;\n  var color = [\"rgba(110, 206, 178, 1)\", \"rgba(0, 133, 124, 1)\"];\n  var color_errorbar = [\"rgba(110, 206, 178, 1)\", \"rgba(0, 133, 124, 1)\"];\n  var color_vline = \"rgba(0, 0, 0, 0.313725490196078)\";\n  var margin = [0, 20, 0, 0, 0];\n  var x_label = \"\";\n  var showlegend = false;\n  var legend_title = \"\";\n  var legend_position = 0;\n  var legend_label = [\"\"];\n\n  return React.createElement(Plot, {\n    data: [\n      \n  {\n    \"x\": [x[0]],\n    \"y\": [y[0]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[0] - x[0]],\n      arrayminus: [x[0] - x_lower[0]],\n      \"color\": color_errorbar[0]\n    },\n    \"text\": text[0],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[0],\n    \"marker\": {\n      \"color\": [color[0]],\n      \"line\": {\n          \"color\": color[0]\n      }\n    },\n    \"line\": {\n        \"color\": color[0]\n    }\n  },\n  {\n    \"x\": [x[1]],\n    \"y\": [y[1]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[1] - x[1]],\n      arrayminus: [x[1] - x_lower[1]],\n      \"color\": color_errorbar[1]\n    },\n    \"text\": text[1],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[1],\n    \"marker\": {\n      \"color\": [color[1]],\n      \"line\": {\n          \"color\": color[1]\n      }\n    },\n    \"line\": {\n        \"color\": color[1]\n    }\n  }\n    ],\n    \"layout\": {\n      \"height\": height,\n      \"width\": width,\n      \"margin\": {\n        \"b\": margin[0],\n        \"l\": margin[1],\n        \"t\": margin[2],\n        \"r\": margin[3],\n        \"pad\": margin[4]\n      },\n      \"xaxis\": {\n        \"domain\": [0,1],\n        \"title\": {\n          \"text\": x_label,\n          \"standoff\": 0,\n          \"font\": {\n            \"size\": 12\n          }\n        },\n        \"range\": x_range,\n        \"showline\": true,\n        \"ticks\": \"outside\",\n        \"zeroline\": false,\n        \"fixedrange\": true\n      },\n      \"yaxis\": {\n        \"domain\": [0,1],\n        \"title\": \"\",\n        \"range\": y_range,\n        \"showgrid\": false,\n        \"zeroline\": false,\n        \"showticklabels\": false,\n        \"fixedrange\": true\n      },\n      \"shapes\": [\n        {\n          \"type\": \"line\",\n          \"y0\": y_range[0],\n          \"y1\": y_range[1],\n          \"yref\": \"paper\",\n          \"x0\": vline,\n          \"x1\": vline,\n          \"line\": {\n            \"color\": color_vline\n          }\n        }\n      ],\n      \"plot_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"paper_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"hoverlabel\": {\n        \"bgcolor\": \"lightgray\"\n      },\n      \"showlegend\": showlegend,\n      \"hovermode\": \"closest\",\n      \"legend\": {\n        \"title\": {\n          \"text\": legend_title\n        },\n        \"orientation\": \"h\",\n        \"xanchor\": \"center\",\n        \"x\": 0.5,\n        \"y\": legend_position\n      }\n    },\n    \"config\": {\n      \"showSendToCloud\": false,\n      \"displayModeBar\": false\n    }\n  })\n}","footer":"/*\n * Copyright (c) 2023 Merck & Co., Inc., Rahway, NJ, USA and its affiliates.\n * All rights reserved.\n *\n * This file is part of the forestly program.\n *\n * forestly is free software: you can redistribute it and/or modify\n * it under the terms of the GNU General Public License as published by\n * the Free Software Foundation, either version 3 of the License, or\n * (at your option) any later version.\n *\n * This program is distributed in the hope that it will be useful,\n * but WITHOUT ANY WARRANTY; without even the implied warranty of\n * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the\n * GNU General Public License for more details.\n *\n * You should have received a copy of the GNU General Public License\n * along with this program.  If not, see <http://www.gnu.org/licenses/>.\n *\n */\n\nfunction(cell, state) {\n  const Plot = createPlotlyComponent(Plotly);\n  var x = [1];\n  var y = [-1];\n  var x_lower = [0];\n  var x_upper = [0];\n  var x_range = [-20, 47];\n  var y_range = [0, 2];\n  var vline = [];\n  var text = [\"\"];\n  var height = 90;\n  var width = 320;\n  var color = [\"rgba(255, 215, 0, 1)\"];\n  var color_errorbar = [\"rgba(255, 255, 255, 0)\"];\n  var color_vline = \"rgba(0, 0, 0, 0.313725490196078)\";\n  var margin = [70, 20, 0, 0, 0];\n  var x_label = \"Treatment <- Favor -> Placebo\";\n  var showlegend = false;\n  var legend_title = \"\";\n  var legend_position = 0;\n  var legend_label = [\"\"];\n\n  return React.createElement(Plot, {\n    data: [\n      \n  {\n    \"x\": [x[0]],\n    \"y\": [y[0]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[0] - x[0]],\n      arrayminus: [x[0] - x_lower[0]],\n      \"color\": color_errorbar[0]\n    },\n    \"text\": 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\"yaxis\": {\n        \"domain\": [0,1],\n        \"title\": \"\",\n        \"range\": y_range,\n        \"showgrid\": false,\n        \"zeroline\": false,\n        \"showticklabels\": false,\n        \"fixedrange\": true\n      },\n      \"shapes\": [\n        {\n          \"type\": \"line\",\n          \"y0\": y_range[0],\n          \"y1\": y_range[1],\n          \"yref\": \"paper\",\n          \"x0\": vline,\n          \"x1\": vline,\n          \"line\": {\n            \"color\": color_vline\n          }\n        }\n      ],\n      \"plot_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"paper_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"hoverlabel\": {\n        \"bgcolor\": \"lightgray\"\n      },\n      \"showlegend\": showlegend,\n      \"hovermode\": \"closest\",\n      \"legend\": {\n        \"title\": {\n          \"text\": legend_title\n        },\n        \"orientation\": \"h\",\n        \"xanchor\": \"center\",\n        \"x\": 0.5,\n        \"y\": legend_position\n      }\n    },\n    \"config\": {\n      \"showSendToCloud\": false,\n      \"displayModeBar\": false\n    }\n  })\n}","html":true,"width":320,"align":"center","style":{"font-size":"0px","padding":"0px","margin":"0px"},"footerStyle":{"font-size":"0px","padding":"0px","margin":"0px"},"show":true},{"id":"n_1","name":"n_1","type":"numeric","header":"n","defaultSortDesc":true,"minWidth":40,"align":"center","show":true},{"id":"n_2","name":"n_2","type":"numeric","header":"n","defaultSortDesc":true,"minWidth":40,"align":"center","show":true},{"id":"n_3","name":"n_3","type":"numeric","header":"n","defaultSortDesc":true,"minWidth":40,"align":"center","show":true},{"id":"prop_1","name":"prop_1","type":"numeric","header":"(%)","defaultSortDesc":true,"format":{"cell":{"prefix":"(","suffix":")","digits":1},"aggregated":{"prefix":"(","suffix":")","digits":1}},"minWidth":60,"align":"center","show":true},{"id":"prop_2","name":"prop_2","type":"numeric","header":"(%)","defaultSortDesc":true,"format":{"cell":{"prefix":"(","suffix":")","digits":1},"aggregated":{"prefix":"(","suffix":")","digits":1}},"minWidth":60,"align":"center","show":true},{"id":"prop_3","name":"prop_3","type":"numeric","header":"(%)","defaultSortDesc":true,"format":{"cell":{"prefix":"(","suffix":")","digits":1},"aggregated":{"prefix":"(","suffix":")","digits":1}},"minWidth":60,"align":"center","show":true},{"id":"diff_2","name":"diff_2","type":"numeric","header":"Low 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-<div id="filter_ae_1476|any adverse events" class="form-group crosstalk-input-select crosstalk-input">
-<label class="control-label" for="filter_ae_1476|any adverse events">AE Criteria</label>
+<div id="filter_ae_04b5a200-7612-4a0b-8a21-742de58aecab|any adverse events" class="form-group crosstalk-input-select crosstalk-input">
+<label class="control-label" for="filter_ae_04b5a200-7612-4a0b-8a21-742de58aecab|any adverse events">AE Criteria</label>
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DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","Congenital, familial and genetic disorders","CONGENITAL, FAMILIAL AND GENETIC DISORDERS","Ear and labyrinth disorders","EAR AND LABYRINTH DISORDERS","EAR AND LABYRINTH DISORDERS","EAR AND LABYRINTH DISORDERS","EAR AND LABYRINTH DISORDERS","Eye disorders","EYE DISORDERS","EYE DISORDERS","EYE DISORDERS","EYE DISORDERS","EYE DISORDERS","EYE DISORDERS","EYE DISORDERS","Gastrointestinal disorders","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","General disorders and administration site conditions","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","Hepatobiliary disorders","HEPATOBILIARY DISORDERS","Immune system disorders","IMMUNE SYSTEM DISORDERS","IMMUNE SYSTEM DISORDERS","Infections and infestations","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","Injury, poisoning and procedural complications","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","Investigations","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","Metabolism and nutrition disorders","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","Musculoskeletal and connective tissue disorders","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","Neoplasms benign, malignant and unspecified (incl cysts and polyps)","NEOPLASMS BENIGN, MALIGNANT AND UNSPECIFIED (INCL CYSTS AND POLYPS)","NEOPLASMS BENIGN, MALIGNANT AND UNSPECIFIED (INCL CYSTS AND POLYPS)","NEOPLASMS BENIGN, MALIGNANT AND UNSPECIFIED (INCL CYSTS AND POLYPS)","Nervous system disorders","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","Psychiatric disorders","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","Renal and urinary disorders","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","Reproductive system and breast disorders","REPRODUCTIVE SYSTEM AND BREAST DISORDERS","REPRODUCTIVE SYSTEM AND BREAST DISORDERS","Respiratory, thoracic and mediastinal disorders","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","Skin and subcutaneous tissue disorders","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","Social circumstances","SOCIAL CIRCUMSTANCES","Surgical and medical procedures","SURGICAL AND MEDICAL PROCEDURES","SURGICAL AND MEDICAL PROCEDURES","SURGICAL AND MEDICAL PROCEDURES","SURGICAL AND MEDICAL PROCEDURES","Vascular disorders","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","Cardiac disorders","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","Congenital, familial and genetic disorders","CONGENITAL, FAMILIAL AND GENETIC DISORDERS","Ear and labyrinth disorders","EAR AND LABYRINTH DISORDERS","EAR AND LABYRINTH DISORDERS","Eye disorders","EYE DISORDERS","Gastrointestinal disorders","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","General disorders and administration site conditions","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","Injury, poisoning and procedural complications","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","Investigations","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","Metabolism and nutrition disorders","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","Musculoskeletal and connective tissue disorders","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","Nervous system disorders","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","Psychiatric disorders","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","Renal and urinary disorders","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","Reproductive system and breast disorders","REPRODUCTIVE SYSTEM AND BREAST DISORDERS","Respiratory, thoracic and mediastinal disorders","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","Skin and subcutaneous tissue disorders","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","Vascular disorders","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","Nervous system disorders","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM 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If not, see <http://www.gnu.org/licenses/>.\n *\n */\n\nfunction(cell, state) {\n  const Plot = createPlotlyComponent(Plotly);\n  var x = [cell.row[\"prop_1\"], cell.row[\"prop_2\"], cell.row[\"prop_3\"]];\n  var y = [1.5, 1, 2];\n  var x_lower = [0];\n  var x_upper = [0];\n  var x_range = [-2, 58];\n  var y_range = [0, 4];\n  var vline = [];\n  var text = [x[0], x[1], x[2]];\n  var height = 30;\n  var width = 320;\n  var color = [\"rgba(0, 0, 0, 1)\", \"rgba(153, 153, 153, 1)\", \"rgba(102, 102, 102, 1)\"];\n  var color_errorbar = [\"rgba(255, 255, 255, 0)\"];\n  var color_vline = \"rgba(0, 0, 0, 0.313725490196078)\";\n  var margin = [0, 0, 0, 0, 0];\n  var x_label = \"\";\n  var showlegend = false;\n  var legend_title = \"\";\n  var legend_position = 0;\n  var legend_label = [\"\"];\n\n  return React.createElement(Plot, {\n    data: [\n      \n  {\n    \"x\": [x[0]],\n    \"y\": [y[0]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[0] - x[0]],\n      arrayminus: [x[0] - x_lower[0]],\n      \"color\": color_errorbar[0]\n    },\n    \"text\": text[0],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[0],\n    \"marker\": {\n      \"color\": [color[0]],\n      \"line\": {\n          \"color\": color[0]\n      }\n    },\n    \"line\": {\n        \"color\": color[0]\n    }\n  },\n  {\n    \"x\": [x[1]],\n    \"y\": [y[1]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[1] - x[1]],\n      arrayminus: [x[1] - x_lower[1]],\n      \"color\": color_errorbar[1]\n    },\n    \"text\": text[1],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[1],\n    \"marker\": {\n      \"color\": [color[1]],\n      \"line\": {\n          \"color\": color[1]\n      }\n    },\n    \"line\": {\n        \"color\": color[1]\n    }\n  },\n  {\n    \"x\": [x[2]],\n    \"y\": [y[2]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[2] - x[2]],\n      arrayminus: [x[2] - x_lower[2]],\n      \"color\": color_errorbar[2]\n    },\n    \"text\": text[2],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[2],\n    \"marker\": {\n      \"color\": [color[2]],\n      \"line\": {\n          \"color\": color[2]\n      }\n    },\n    \"line\": {\n        \"color\": color[2]\n    }\n  }\n    ],\n    \"layout\": {\n      \"height\": height,\n      \"width\": width,\n      \"margin\": {\n        \"b\": margin[0],\n        \"l\": margin[1],\n        \"t\": margin[2],\n        \"r\": margin[3],\n        \"pad\": margin[4]\n      },\n      \"xaxis\": {\n        \"domain\": [0,1],\n        \"title\": {\n          \"text\": x_label,\n          \"standoff\": 0,\n          \"font\": {\n            \"size\": 12\n          }\n        },\n        \"range\": x_range,\n        \"showline\": true,\n        \"ticks\": \"outside\",\n        \"zeroline\": false,\n        \"fixedrange\": true\n      },\n      \"yaxis\": {\n        \"domain\": [0,1],\n        \"title\": \"\",\n        \"range\": y_range,\n        \"showgrid\": false,\n        \"zeroline\": false,\n        \"showticklabels\": false,\n        \"fixedrange\": true\n      },\n      \"shapes\": [\n        {\n          \"type\": \"line\",\n          \"y0\": y_range[0],\n          \"y1\": y_range[1],\n          \"yref\": \"paper\",\n          \"x0\": vline,\n          \"x1\": vline,\n          \"line\": {\n            \"color\": color_vline\n          }\n        }\n      ],\n      \"plot_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"paper_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"hoverlabel\": {\n        \"bgcolor\": \"lightgray\"\n      },\n      \"showlegend\": showlegend,\n      \"hovermode\": \"closest\",\n      \"legend\": {\n        \"title\": {\n          \"text\": legend_title\n        },\n        \"orientation\": \"h\",\n        \"xanchor\": \"center\",\n        \"x\": 0.5,\n        \"y\": legend_position\n      }\n    },\n    \"config\": {\n      \"showSendToCloud\": false,\n      \"displayModeBar\": false\n    }\n  })\n}","footer":"/*\n * Copyright (c) 2023 Merck & Co., Inc., Rahway, NJ, USA and its affiliates.\n * All rights reserved.\n *\n * This file is part of the forestly program.\n *\n * forestly is free software: you can redistribute it and/or modify\n * it under the terms of the GNU General Public License as published by\n * the Free Software Foundation, either version 3 of the License, or\n * (at your option) any later version.\n *\n * This program is distributed in the hope that it will be useful,\n * but WITHOUT ANY WARRANTY; without even the implied warranty of\n * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the\n * GNU General Public License for more details.\n *\n * You should have received a copy of the GNU General Public License\n * along with this program.  If not, see <http://www.gnu.org/licenses/>.\n *\n */\n\nfunction(cell, state) {\n  const Plot = createPlotlyComponent(Plotly);\n  var x = [1, 2, 3];\n  var y = [-1, -1, -1];\n  var x_lower = [0];\n  var x_upper = [0];\n  var x_range = [-2, 58];\n  var y_range = [0, 4];\n  var vline = [];\n  var text = [\"\", \"\", \"\"];\n  var height = 90;\n  var width = 320;\n  var color = [\"rgba(0, 0, 0, 1)\", \"rgba(153, 153, 153, 1)\", \"rgba(102, 102, 102, 1)\"];\n  var color_errorbar = [\"rgba(255, 255, 255, 0)\"];\n  var color_vline = \"rgba(0, 0, 0, 0.313725490196078)\";\n  var margin = [70, 0, 0, 0, 0];\n  var x_label = \"\";\n  var showlegend = true;\n  var legend_title = \"\";\n  var legend_position = -0.8;\n  var legend_label = [\"Placebo\", \"Low Dose\", \"High Dose\"];\n\n  return React.createElement(Plot, {\n    data: [\n      \n  {\n    \"x\": [x[0]],\n    \"y\": [y[0]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[0] - x[0]],\n      arrayminus: [x[0] - 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See the\n * GNU General Public License for more details.\n *\n * You should have received a copy of the GNU General Public License\n * along with this program.  If not, see <http://www.gnu.org/licenses/>.\n *\n */\n\nfunction(cell, state) {\n  const Plot = createPlotlyComponent(Plotly);\n  var x = [cell.row[\"diff_2\"], cell.row[\"diff_3\"]];\n  var y = [1, 2];\n  var x_lower = [cell.row[\"lower_2\"], cell.row[\"lower_3\"]];\n  var x_upper = [cell.row[\"upper_2\"], cell.row[\"upper_3\"]];\n  var x_range = [-20, 47];\n  var y_range = [0, 3];\n  var vline = [];\n  var text = [x[0] + '(' + x_lower[0] + ', ' + x_upper[0] + ')', x[1] + '(' + x_lower[1] + ', ' + x_upper[1] + ')'];\n  var height = 30;\n  var width = 320;\n  var color = [\"rgba(153, 153, 153, 1)\", \"rgba(102, 102, 102, 1)\"];\n  var color_errorbar = [\"rgba(153, 153, 153, 1)\", \"rgba(102, 102, 102, 1)\"];\n  var color_vline = \"rgba(0, 0, 0, 0.313725490196078)\";\n  var margin = [0, 20, 0, 0, 0];\n  var x_label = \"\";\n  var showlegend = false;\n  var legend_title = \"\";\n  var legend_position = 0;\n  var legend_label = [\"\"];\n\n  return React.createElement(Plot, {\n    data: [\n      \n  {\n    \"x\": [x[0]],\n    \"y\": [y[0]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[0] - x[0]],\n      arrayminus: [x[0] - x_lower[0]],\n      \"color\": color_errorbar[0]\n    },\n    \"text\": text[0],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[0],\n    \"marker\": {\n      \"color\": [color[0]],\n      \"line\": {\n          \"color\": color[0]\n      }\n    },\n    \"line\": {\n        \"color\": color[0]\n    }\n  },\n  {\n    \"x\": [x[1]],\n    \"y\": [y[1]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[1] - x[1]],\n      arrayminus: [x[1] - x_lower[1]],\n      \"color\": color_errorbar[1]\n    },\n    \"text\": text[1],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[1],\n    \"marker\": {\n      \"color\": [color[1]],\n      \"line\": {\n          \"color\": color[1]\n      }\n    },\n    \"line\": {\n        \"color\": color[1]\n    }\n  }\n    ],\n    \"layout\": {\n      \"height\": height,\n      \"width\": width,\n      \"margin\": {\n        \"b\": margin[0],\n        \"l\": margin[1],\n        \"t\": margin[2],\n        \"r\": margin[3],\n        \"pad\": margin[4]\n      },\n      \"xaxis\": {\n        \"domain\": [0,1],\n        \"title\": {\n          \"text\": x_label,\n          \"standoff\": 0,\n          \"font\": {\n            \"size\": 12\n          }\n        },\n        \"range\": x_range,\n        \"showline\": true,\n        \"ticks\": \"outside\",\n        \"zeroline\": false,\n        \"fixedrange\": true\n      },\n      \"yaxis\": {\n        \"domain\": [0,1],\n        \"title\": \"\",\n        \"range\": y_range,\n        \"showgrid\": false,\n        \"zeroline\": false,\n        \"showticklabels\": false,\n        \"fixedrange\": true\n      },\n      \"shapes\": [\n        {\n          \"type\": \"line\",\n          \"y0\": y_range[0],\n          \"y1\": y_range[1],\n          \"yref\": \"paper\",\n          \"x0\": vline,\n          \"x1\": vline,\n          \"line\": {\n            \"color\": color_vline\n          }\n        }\n      ],\n      \"plot_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"paper_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"hoverlabel\": {\n        \"bgcolor\": \"lightgray\"\n      },\n      \"showlegend\": showlegend,\n      \"hovermode\": \"closest\",\n      \"legend\": {\n        \"title\": {\n          \"text\": legend_title\n        },\n        \"orientation\": \"h\",\n        \"xanchor\": \"center\",\n        \"x\": 0.5,\n        \"y\": legend_position\n      }\n    },\n    \"config\": {\n      \"showSendToCloud\": false,\n      \"displayModeBar\": false\n    }\n  })\n}","footer":"/*\n * Copyright (c) 2023 Merck & Co., Inc., Rahway, NJ, USA and its affiliates.\n * All rights reserved.\n *\n * This file is part of the forestly program.\n *\n * forestly is free software: you can redistribute it and/or modify\n * it under the terms of the GNU General Public License as published by\n * the Free Software Foundation, either version 3 of the License, or\n * (at your option) any later version.\n *\n * This program is distributed in the hope that it will be useful,\n * but WITHOUT ANY WARRANTY; without even the implied warranty of\n * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the\n * GNU General Public License for more details.\n *\n * You should have received a copy of the GNU General Public License\n * along with this program.  If not, see <http://www.gnu.org/licenses/>.\n *\n */\n\nfunction(cell, state) {\n  const Plot = createPlotlyComponent(Plotly);\n  var x = [1];\n  var y = [-1];\n  var x_lower = [0];\n  var x_upper = [0];\n  var x_range = [-20, 47];\n  var y_range = [0, 2];\n  var vline = [];\n  var text = [\"\"];\n  var height = 90;\n  var width = 320;\n  var color = [\"rgba(255, 215, 0, 1)\"];\n  var color_errorbar = [\"rgba(255, 255, 255, 0)\"];\n  var color_vline = \"rgba(0, 0, 0, 0.313725490196078)\";\n  var margin = [70, 20, 0, 0, 0];\n  var x_label = \"Treatment <- Favor -> Placebo\";\n  var showlegend = false;\n  var legend_title = \"\";\n  var legend_position = 0;\n  var legend_label = [\"\"];\n\n  return React.createElement(Plot, {\n    data: [\n      \n  {\n    \"x\": [x[0]],\n    \"y\": [y[0]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[0] - x[0]],\n      arrayminus: [x[0] - x_lower[0]],\n      \"color\": color_errorbar[0]\n    },\n    \"text\": 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\"yaxis\": {\n        \"domain\": [0,1],\n        \"title\": \"\",\n        \"range\": y_range,\n        \"showgrid\": false,\n        \"zeroline\": false,\n        \"showticklabels\": false,\n        \"fixedrange\": true\n      },\n      \"shapes\": [\n        {\n          \"type\": \"line\",\n          \"y0\": y_range[0],\n          \"y1\": y_range[1],\n          \"yref\": \"paper\",\n          \"x0\": vline,\n          \"x1\": vline,\n          \"line\": {\n            \"color\": color_vline\n          }\n        }\n      ],\n      \"plot_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"paper_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"hoverlabel\": {\n        \"bgcolor\": \"lightgray\"\n      },\n      \"showlegend\": showlegend,\n      \"hovermode\": \"closest\",\n      \"legend\": {\n        \"title\": {\n          \"text\": legend_title\n        },\n        \"orientation\": \"h\",\n        \"xanchor\": \"center\",\n        \"x\": 0.5,\n        \"y\": legend_position\n      }\n    },\n    \"config\": {\n      \"showSendToCloud\": false,\n      \"displayModeBar\": false\n    }\n  })\n}","html":true,"width":320,"align":"center","style":{"font-size":"0px","padding":"0px","margin":"0px"},"footerStyle":{"font-size":"0px","padding":"0px","margin":"0px"},"show":true},{"id":"n_1","name":"n_1","type":"numeric","header":"n","defaultSortDesc":true,"minWidth":40,"align":"center","show":true},{"id":"n_2","name":"n_2","type":"numeric","header":"n","defaultSortDesc":true,"minWidth":40,"align":"center","show":true},{"id":"n_3","name":"n_3","type":"numeric","header":"n","defaultSortDesc":true,"minWidth":40,"align":"center","show":true},{"id":"prop_1","name":"prop_1","type":"numeric","header":"(%)","defaultSortDesc":true,"format":{"cell":{"prefix":"(","suffix":")","digits":1},"aggregated":{"prefix":"(","suffix":")","digits":1}},"minWidth":60,"align":"center","show":true},{"id":"prop_2","name":"prop_2","type":"numeric","header":"(%)","defaultSortDesc":true,"format":{"cell":{"prefix":"(","suffix":")","digits":1},"aggregated":{"prefix":"(","suffix":")","digits":1}},"minWidth":60,"align":"center","show":true},{"id":"prop_3","name":"prop_3","type":"numeric","header":"(%)","defaultSortDesc":true,"format":{"cell":{"prefix":"(","suffix":")","digits":1},"aggregated":{"prefix":"(","suffix":")","digits":1}},"minWidth":60,"align":"center","show":true},{"id":"diff_2","name":"diff_2","type":"numeric","header":"Low 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@@ -250,20 +257,20 @@ <h2 id="display-different-columns">Display different columns<a class="anchor" ar
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 <div class="row">
 <div class="col-xs-3">
-<div id="filter_ae_9983|any adverse events" class="form-group crosstalk-input-select crosstalk-input">
-<label class="control-label" for="filter_ae_9983|any adverse events">AE Criteria</label>
+<div id="filter_ae_a880ac83-acc9-4883-bd74-4128a6d94447|any adverse events" class="form-group crosstalk-input-select crosstalk-input">
+<label class="control-label" for="filter_ae_a880ac83-acc9-4883-bd74-4128a6d94447|any adverse events">AE Criteria</label>
 <div>
-<select></select><script type="application/json" data-for="filter_ae_9983|any adverse events">{
+<select></select><script type="application/json" data-for="filter_ae_a880ac83-acc9-4883-bd74-4128a6d94447|any adverse events">{
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See the\n * GNU General Public License for more details.\n *\n * You should have received a copy of the GNU General Public License\n * along with this program.  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See the\n * GNU General Public License for more details.\n *\n * You should have received a copy of the GNU General Public License\n * along with this program.  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conditions","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","Hepatobiliary disorders","HEPATOBILIARY DISORDERS","Immune system disorders","IMMUNE SYSTEM DISORDERS","IMMUNE SYSTEM DISORDERS","Infections and infestations","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","Injury, poisoning and procedural complications","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","Investigations","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","Metabolism and nutrition disorders","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","Musculoskeletal and connective tissue disorders","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","Neoplasms benign, malignant and unspecified (incl cysts and polyps)","NEOPLASMS BENIGN, MALIGNANT AND UNSPECIFIED (INCL CYSTS AND POLYPS)","NEOPLASMS BENIGN, MALIGNANT AND UNSPECIFIED (INCL CYSTS AND POLYPS)","NEOPLASMS BENIGN, MALIGNANT AND UNSPECIFIED (INCL CYSTS AND POLYPS)","Nervous system disorders","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","Psychiatric disorders","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","Renal and urinary disorders","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","Reproductive system and breast disorders","REPRODUCTIVE SYSTEM AND BREAST DISORDERS","REPRODUCTIVE SYSTEM AND BREAST DISORDERS","Respiratory, thoracic and mediastinal disorders","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","Skin and subcutaneous tissue disorders","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","Social circumstances","SOCIAL CIRCUMSTANCES","Surgical and medical procedures","SURGICAL AND MEDICAL PROCEDURES","SURGICAL AND MEDICAL PROCEDURES","SURGICAL AND MEDICAL PROCEDURES","SURGICAL AND MEDICAL PROCEDURES","Vascular disorders","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","Cardiac disorders","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","Congenital, familial and genetic disorders","CONGENITAL, FAMILIAL AND GENETIC DISORDERS","Ear and labyrinth disorders","EAR AND LABYRINTH DISORDERS","EAR AND LABYRINTH DISORDERS","Eye disorders","EYE DISORDERS","Gastrointestinal disorders","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","General disorders and administration site conditions","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","Injury, poisoning and procedural complications","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","Investigations","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","Metabolism and nutrition disorders","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","Musculoskeletal and connective tissue disorders","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","Nervous system disorders","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","Psychiatric disorders","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","Renal and urinary disorders","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","Reproductive system and breast disorders","REPRODUCTIVE SYSTEM AND BREAST DISORDERS","Respiratory, thoracic and mediastinal disorders","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","Skin and subcutaneous tissue disorders","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","Vascular disorders","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","Nervous system disorders","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM 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If not, see <http://www.gnu.org/licenses/>.\n *\n */\n\nfunction(cell, state) {\n  const Plot = createPlotlyComponent(Plotly);\n  var x = [cell.row[\"prop_1\"], cell.row[\"prop_2\"], cell.row[\"prop_3\"]];\n  var y = [1.5, 1, 2];\n  var x_lower = [0];\n  var x_upper = [0];\n  var x_range = [-2, 58];\n  var y_range = [0, 4];\n  var vline = [];\n  var text = [x[0], x[1], x[2]];\n  var height = 30;\n  var width = 320;\n  var color = [\"rgba(102, 32, 58, 1)\", \"rgba(110, 206, 178, 1)\", \"rgba(0, 133, 124, 1)\"];\n  var color_errorbar = [\"rgba(255, 255, 255, 0)\"];\n  var color_vline = \"rgba(0, 0, 0, 0.313725490196078)\";\n  var margin = [0, 0, 0, 0, 0];\n  var x_label = \"\";\n  var showlegend = false;\n  var legend_title = \"\";\n  var legend_position = 0;\n  var legend_label = [\"\"];\n\n  return React.createElement(Plot, {\n    data: [\n      \n  {\n    \"x\": [x[0]],\n    \"y\": [y[0]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[0] - x[0]],\n      arrayminus: [x[0] - x_lower[0]],\n      \"color\": color_errorbar[0]\n    },\n    \"text\": text[0],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[0],\n    \"marker\": {\n      \"color\": [color[0]],\n      \"line\": {\n          \"color\": color[0]\n      }\n    },\n    \"line\": {\n        \"color\": color[0]\n    }\n  },\n  {\n    \"x\": [x[1]],\n    \"y\": [y[1]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[1] - x[1]],\n      arrayminus: [x[1] - x_lower[1]],\n      \"color\": color_errorbar[1]\n    },\n    \"text\": text[1],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[1],\n    \"marker\": {\n      \"color\": [color[1]],\n      \"line\": {\n          \"color\": color[1]\n      }\n    },\n    \"line\": {\n        \"color\": color[1]\n    }\n  },\n  {\n    \"x\": [x[2]],\n    \"y\": [y[2]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[2] - x[2]],\n      arrayminus: [x[2] - x_lower[2]],\n      \"color\": color_errorbar[2]\n    },\n    \"text\": text[2],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[2],\n    \"marker\": {\n      \"color\": [color[2]],\n      \"line\": {\n          \"color\": color[2]\n      }\n    },\n    \"line\": {\n        \"color\": color[2]\n    }\n  }\n    ],\n    \"layout\": {\n      \"height\": height,\n      \"width\": width,\n      \"margin\": {\n        \"b\": margin[0],\n        \"l\": margin[1],\n        \"t\": margin[2],\n        \"r\": margin[3],\n        \"pad\": margin[4]\n      },\n      \"xaxis\": {\n        \"domain\": [0,1],\n        \"title\": {\n          \"text\": x_label,\n          \"standoff\": 0,\n          \"font\": {\n            \"size\": 12\n          }\n        },\n        \"range\": x_range,\n        \"showline\": true,\n        \"ticks\": \"outside\",\n        \"zeroline\": false,\n        \"fixedrange\": true\n      },\n      \"yaxis\": {\n        \"domain\": [0,1],\n        \"title\": \"\",\n        \"range\": y_range,\n        \"showgrid\": false,\n        \"zeroline\": false,\n        \"showticklabels\": false,\n        \"fixedrange\": true\n      },\n      \"shapes\": [\n        {\n          \"type\": \"line\",\n          \"y0\": y_range[0],\n          \"y1\": y_range[1],\n          \"yref\": \"paper\",\n          \"x0\": vline,\n          \"x1\": vline,\n          \"line\": {\n            \"color\": color_vline\n          }\n        }\n      ],\n      \"plot_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"paper_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"hoverlabel\": {\n        \"bgcolor\": \"lightgray\"\n      },\n      \"showlegend\": showlegend,\n      \"hovermode\": \"closest\",\n      \"legend\": {\n        \"title\": {\n          \"text\": legend_title\n        },\n        \"orientation\": \"h\",\n        \"xanchor\": \"center\",\n        \"x\": 0.5,\n        \"y\": legend_position\n      }\n    },\n    \"config\": {\n      \"showSendToCloud\": false,\n      \"displayModeBar\": false\n    }\n  })\n}","footer":"/*\n * Copyright (c) 2023 Merck & Co., Inc., Rahway, NJ, USA and its affiliates.\n * All rights reserved.\n *\n * This file is part of the forestly program.\n *\n * forestly is free software: you can redistribute it and/or modify\n * it under the terms of the GNU General Public License as published by\n * the Free Software Foundation, either version 3 of the License, or\n * (at your option) any later version.\n *\n * This program is distributed in the hope that it will be useful,\n * but WITHOUT ANY WARRANTY; without even the implied warranty of\n * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the\n * GNU General Public License for more details.\n *\n * You should have received a copy of the GNU General Public License\n * along with this program.  If not, see <http://www.gnu.org/licenses/>.\n *\n */\n\nfunction(cell, state) {\n  const Plot = createPlotlyComponent(Plotly);\n  var x = [1, 2, 3];\n  var y = [-1, -1, -1];\n  var x_lower = [0];\n  var x_upper = [0];\n  var x_range = [-2, 58];\n  var y_range = [0, 4];\n  var vline = [];\n  var text = [\"\", \"\", \"\"];\n  var height = 90;\n  var width = 320;\n  var color = [\"rgba(102, 32, 58, 1)\", \"rgba(110, 206, 178, 1)\", \"rgba(0, 133, 124, 1)\"];\n  var color_errorbar = [\"rgba(255, 255, 255, 0)\"];\n  var color_vline = \"rgba(0, 0, 0, 0.313725490196078)\";\n  var margin = [70, 0, 0, 0, 0];\n  var x_label = \"\";\n  var showlegend = true;\n  var legend_title = \"\";\n  var legend_position = -0.8;\n  var legend_label = [\"Placebo\", \"Low Dose\", \"High Dose\"];\n\n  return React.createElement(Plot, {\n    data: [\n      \n  {\n    \"x\": [x[0]],\n    \"y\": [y[0]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[0] - x[0]],\n      arrayminus: [x[0] - 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See the\n * GNU General Public License for more details.\n *\n * You should have received a copy of the GNU General Public License\n * along with this program.  If not, see <http://www.gnu.org/licenses/>.\n *\n */\n\nfunction(cell, state) {\n  const Plot = createPlotlyComponent(Plotly);\n  var x = [cell.row[\"diff_2\"], cell.row[\"diff_3\"]];\n  var y = [1, 2];\n  var x_lower = [cell.row[\"lower_2\"], cell.row[\"lower_3\"]];\n  var x_upper = [cell.row[\"upper_2\"], cell.row[\"upper_3\"]];\n  var x_range = [-20, 47];\n  var y_range = [0, 3];\n  var vline = [];\n  var text = [x[0] + '(' + x_lower[0] + ', ' + x_upper[0] + ')', x[1] + '(' + x_lower[1] + ', ' + x_upper[1] + ')'];\n  var height = 30;\n  var width = 320;\n  var color = [\"rgba(110, 206, 178, 1)\", \"rgba(0, 133, 124, 1)\"];\n  var color_errorbar = [\"rgba(110, 206, 178, 1)\", \"rgba(0, 133, 124, 1)\"];\n  var color_vline = \"rgba(0, 0, 0, 0.313725490196078)\";\n  var margin = [0, 20, 0, 0, 0];\n  var x_label = \"\";\n  var showlegend = false;\n  var legend_title = \"\";\n  var legend_position = 0;\n  var legend_label = [\"\"];\n\n  return React.createElement(Plot, {\n    data: [\n      \n  {\n    \"x\": [x[0]],\n    \"y\": [y[0]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[0] - x[0]],\n      arrayminus: [x[0] - x_lower[0]],\n      \"color\": color_errorbar[0]\n    },\n    \"text\": text[0],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[0],\n    \"marker\": {\n      \"color\": [color[0]],\n      \"line\": {\n          \"color\": color[0]\n      }\n    },\n    \"line\": {\n        \"color\": color[0]\n    }\n  },\n  {\n    \"x\": [x[1]],\n    \"y\": [y[1]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[1] - x[1]],\n      arrayminus: [x[1] - x_lower[1]],\n      \"color\": color_errorbar[1]\n    },\n    \"text\": text[1],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[1],\n    \"marker\": {\n      \"color\": [color[1]],\n      \"line\": {\n          \"color\": color[1]\n      }\n    },\n    \"line\": {\n        \"color\": color[1]\n    }\n  }\n    ],\n    \"layout\": {\n      \"height\": height,\n      \"width\": width,\n      \"margin\": {\n        \"b\": margin[0],\n        \"l\": margin[1],\n        \"t\": margin[2],\n        \"r\": margin[3],\n        \"pad\": margin[4]\n      },\n      \"xaxis\": {\n        \"domain\": [0,1],\n        \"title\": {\n          \"text\": x_label,\n          \"standoff\": 0,\n          \"font\": {\n            \"size\": 12\n          }\n        },\n        \"range\": x_range,\n        \"showline\": true,\n        \"ticks\": \"outside\",\n        \"zeroline\": false,\n        \"fixedrange\": true\n      },\n      \"yaxis\": {\n        \"domain\": [0,1],\n        \"title\": \"\",\n        \"range\": y_range,\n        \"showgrid\": false,\n        \"zeroline\": false,\n        \"showticklabels\": false,\n        \"fixedrange\": true\n      },\n      \"shapes\": [\n        {\n          \"type\": \"line\",\n          \"y0\": y_range[0],\n          \"y1\": y_range[1],\n          \"yref\": \"paper\",\n          \"x0\": vline,\n          \"x1\": vline,\n          \"line\": {\n            \"color\": color_vline\n          }\n        }\n      ],\n      \"plot_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"paper_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"hoverlabel\": {\n        \"bgcolor\": \"lightgray\"\n      },\n      \"showlegend\": showlegend,\n      \"hovermode\": \"closest\",\n      \"legend\": {\n        \"title\": {\n          \"text\": legend_title\n        },\n        \"orientation\": \"h\",\n        \"xanchor\": \"center\",\n        \"x\": 0.5,\n        \"y\": legend_position\n      }\n    },\n    \"config\": {\n      \"showSendToCloud\": false,\n      \"displayModeBar\": false\n    }\n  })\n}","footer":"/*\n * Copyright (c) 2023 Merck & Co., Inc., Rahway, NJ, USA and its affiliates.\n * All rights reserved.\n *\n * This file is part of the forestly program.\n *\n * forestly is free software: you can redistribute it and/or modify\n * it under the terms of the GNU General Public License as published by\n * the Free Software Foundation, either version 3 of the License, or\n * (at your option) any later version.\n *\n * This program is distributed in the hope that it will be useful,\n * but WITHOUT ANY WARRANTY; without even the implied warranty of\n * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the\n * GNU General Public License for more details.\n *\n * You should have received a copy of the GNU General Public License\n * along with this program.  If not, see <http://www.gnu.org/licenses/>.\n *\n */\n\nfunction(cell, state) {\n  const Plot = createPlotlyComponent(Plotly);\n  var x = [1];\n  var y = [-1];\n  var x_lower = [0];\n  var x_upper = [0];\n  var x_range = [-20, 47];\n  var y_range = [0, 2];\n  var vline = [];\n  var text = [\"\"];\n  var height = 90;\n  var width = 320;\n  var color = [\"rgba(255, 215, 0, 1)\"];\n  var color_errorbar = [\"rgba(255, 255, 255, 0)\"];\n  var color_vline = \"rgba(0, 0, 0, 0.313725490196078)\";\n  var margin = [70, 20, 0, 0, 0];\n  var x_label = \"Treatment <- Favor -> Placebo\";\n  var showlegend = false;\n  var legend_title = \"\";\n  var legend_position = 0;\n  var legend_label = [\"\"];\n\n  return React.createElement(Plot, {\n    data: [\n      \n  {\n    \"x\": [x[0]],\n    \"y\": [y[0]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[0] - x[0]],\n      arrayminus: [x[0] - x_lower[0]],\n      \"color\": color_errorbar[0]\n    },\n    \"text\": 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 <div class="row">
 <div class="col-xs-3">
-<div id="filter_ae_2615|any adverse events" class="form-group crosstalk-input-select crosstalk-input">
-<label class="control-label" for="filter_ae_2615|any adverse events">AE Criteria</label>
+<div id="filter_ae_60a52475-a632-4400-b362-e88ca382ea03|any adverse events" class="form-group crosstalk-input-select crosstalk-input">
+<label class="control-label" for="filter_ae_60a52475-a632-4400-b362-e88ca382ea03|any adverse events">AE Criteria</label>
 <div>
-<select></select><script type="application/json" data-for="filter_ae_2615|any adverse events">{
+<select></select><script type="application/json" data-for="filter_ae_60a52475-a632-4400-b362-e88ca382ea03|any adverse events">{
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DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","Congenital, familial and genetic disorders","CONGENITAL, FAMILIAL AND GENETIC DISORDERS","Ear and labyrinth disorders","EAR AND LABYRINTH DISORDERS","EAR AND LABYRINTH DISORDERS","EAR AND LABYRINTH DISORDERS","EAR AND LABYRINTH DISORDERS","Eye disorders","EYE DISORDERS","EYE DISORDERS","EYE DISORDERS","EYE DISORDERS","EYE DISORDERS","EYE DISORDERS","EYE DISORDERS","Gastrointestinal disorders","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","General disorders and administration site conditions","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","Hepatobiliary disorders","HEPATOBILIARY DISORDERS","Immune system disorders","IMMUNE SYSTEM DISORDERS","IMMUNE SYSTEM DISORDERS","Infections and infestations","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","Injury, poisoning and procedural complications","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","Investigations","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","Metabolism and nutrition disorders","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","Musculoskeletal and connective tissue disorders","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","Neoplasms benign, malignant and unspecified (incl cysts and polyps)","NEOPLASMS BENIGN, MALIGNANT AND UNSPECIFIED (INCL CYSTS AND POLYPS)","NEOPLASMS BENIGN, MALIGNANT AND UNSPECIFIED (INCL CYSTS AND POLYPS)","NEOPLASMS BENIGN, MALIGNANT AND UNSPECIFIED (INCL CYSTS AND POLYPS)","Nervous system disorders","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","Psychiatric disorders","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","Renal and urinary disorders","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","Reproductive system and breast disorders","REPRODUCTIVE SYSTEM AND BREAST DISORDERS","REPRODUCTIVE SYSTEM AND BREAST DISORDERS","Respiratory, thoracic and mediastinal disorders","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","Skin and subcutaneous tissue disorders","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","Social circumstances","SOCIAL CIRCUMSTANCES","Surgical and medical procedures","SURGICAL AND MEDICAL PROCEDURES","SURGICAL AND MEDICAL PROCEDURES","SURGICAL AND MEDICAL PROCEDURES","SURGICAL AND MEDICAL PROCEDURES","Vascular disorders","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","Cardiac disorders","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","Congenital, familial and genetic disorders","CONGENITAL, FAMILIAL AND GENETIC DISORDERS","Ear and labyrinth disorders","EAR AND LABYRINTH DISORDERS","EAR AND LABYRINTH DISORDERS","Eye disorders","EYE DISORDERS","Gastrointestinal disorders","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","General disorders and administration site conditions","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","Injury, poisoning and procedural complications","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","Investigations","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","Metabolism and nutrition disorders","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","Musculoskeletal and connective tissue disorders","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","Nervous system disorders","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","Psychiatric disorders","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","Renal and urinary disorders","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","Reproductive system and breast disorders","REPRODUCTIVE SYSTEM AND BREAST DISORDERS","Respiratory, thoracic and mediastinal disorders","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","Skin and subcutaneous tissue disorders","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","Vascular disorders","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","Nervous system disorders","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM 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If not, see <http://www.gnu.org/licenses/>.\n *\n */\n\nfunction(cell, state) {\n  const Plot = createPlotlyComponent(Plotly);\n  var x = [cell.row[\"prop_1\"], cell.row[\"prop_2\"], cell.row[\"prop_3\"]];\n  var y = [1.5, 1, 2];\n  var x_lower = [0];\n  var x_upper = [0];\n  var x_range = [-2, 58];\n  var y_range = [0, 4];\n  var vline = [];\n  var text = [x[0], x[1], x[2]];\n  var height = 30;\n  var width = 320;\n  var color = [\"rgba(102, 32, 58, 1)\", \"rgba(110, 206, 178, 1)\", \"rgba(0, 133, 124, 1)\"];\n  var color_errorbar = [\"rgba(255, 255, 255, 0)\"];\n  var color_vline = \"rgba(0, 0, 0, 0.313725490196078)\";\n  var margin = [0, 0, 0, 0, 0];\n  var x_label = \"\";\n  var showlegend = false;\n  var legend_title = \"\";\n  var legend_position = 0;\n  var legend_label = [\"\"];\n\n  return React.createElement(Plot, {\n    data: [\n      \n  {\n    \"x\": [x[0]],\n    \"y\": [y[0]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[0] - x[0]],\n      arrayminus: [x[0] - x_lower[0]],\n      \"color\": color_errorbar[0]\n    },\n    \"text\": text[0],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[0],\n    \"marker\": {\n      \"color\": [color[0]],\n      \"line\": {\n          \"color\": color[0]\n      }\n    },\n    \"line\": {\n        \"color\": color[0]\n    }\n  },\n  {\n    \"x\": [x[1]],\n    \"y\": [y[1]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[1] - x[1]],\n      arrayminus: [x[1] - x_lower[1]],\n      \"color\": color_errorbar[1]\n    },\n    \"text\": text[1],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[1],\n    \"marker\": {\n      \"color\": [color[1]],\n      \"line\": {\n          \"color\": color[1]\n      }\n    },\n    \"line\": {\n        \"color\": color[1]\n    }\n  },\n  {\n    \"x\": [x[2]],\n    \"y\": [y[2]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[2] - x[2]],\n      arrayminus: [x[2] - x_lower[2]],\n      \"color\": color_errorbar[2]\n    },\n    \"text\": text[2],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[2],\n    \"marker\": {\n      \"color\": [color[2]],\n      \"line\": {\n          \"color\": color[2]\n      }\n    },\n    \"line\": {\n        \"color\": color[2]\n    }\n  }\n    ],\n    \"layout\": {\n      \"height\": height,\n      \"width\": width,\n      \"margin\": {\n        \"b\": margin[0],\n        \"l\": margin[1],\n        \"t\": margin[2],\n        \"r\": margin[3],\n        \"pad\": margin[4]\n      },\n      \"xaxis\": {\n        \"domain\": [0,1],\n        \"title\": {\n          \"text\": x_label,\n          \"standoff\": 0,\n          \"font\": {\n            \"size\": 12\n          }\n        },\n        \"range\": x_range,\n        \"showline\": true,\n        \"ticks\": \"outside\",\n        \"zeroline\": false,\n        \"fixedrange\": true\n      },\n      \"yaxis\": {\n        \"domain\": [0,1],\n        \"title\": \"\",\n        \"range\": y_range,\n        \"showgrid\": false,\n        \"zeroline\": false,\n        \"showticklabels\": false,\n        \"fixedrange\": true\n      },\n      \"shapes\": [\n        {\n          \"type\": \"line\",\n          \"y0\": y_range[0],\n          \"y1\": y_range[1],\n          \"yref\": \"paper\",\n          \"x0\": vline,\n          \"x1\": vline,\n          \"line\": {\n            \"color\": color_vline\n          }\n        }\n      ],\n      \"plot_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"paper_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"hoverlabel\": {\n        \"bgcolor\": \"lightgray\"\n      },\n      \"showlegend\": showlegend,\n      \"hovermode\": \"closest\",\n      \"legend\": {\n        \"title\": {\n          \"text\": legend_title\n        },\n        \"orientation\": \"h\",\n        \"xanchor\": \"center\",\n        \"x\": 0.5,\n        \"y\": legend_position\n      }\n    },\n    \"config\": {\n      \"showSendToCloud\": false,\n      \"displayModeBar\": false\n    }\n  })\n}","footer":"/*\n * Copyright (c) 2023 Merck & Co., Inc., Rahway, NJ, USA and its affiliates.\n * All rights reserved.\n *\n * This file is part of the forestly program.\n *\n * forestly is free software: you can redistribute it and/or modify\n * it under the terms of the GNU General Public License as published by\n * the Free Software Foundation, either version 3 of the License, or\n * (at your option) any later version.\n *\n * This program is distributed in the hope that it will be useful,\n * but WITHOUT ANY WARRANTY; without even the implied warranty of\n * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the\n * GNU General Public License for more details.\n *\n * You should have received a copy of the GNU General Public License\n * along with this program.  If not, see <http://www.gnu.org/licenses/>.\n *\n */\n\nfunction(cell, state) {\n  const Plot = createPlotlyComponent(Plotly);\n  var x = [1, 2, 3];\n  var y = [-1, -1, -1];\n  var x_lower = [0];\n  var x_upper = [0];\n  var x_range = [-2, 58];\n  var y_range = [0, 4];\n  var vline = [];\n  var text = [\"\", \"\", \"\"];\n  var height = 90;\n  var width = 320;\n  var color = [\"rgba(102, 32, 58, 1)\", \"rgba(110, 206, 178, 1)\", \"rgba(0, 133, 124, 1)\"];\n  var color_errorbar = [\"rgba(255, 255, 255, 0)\"];\n  var color_vline = \"rgba(0, 0, 0, 0.313725490196078)\";\n  var margin = [70, 0, 0, 0, 0];\n  var x_label = \"\";\n  var showlegend = true;\n  var legend_title = \"\";\n  var legend_position = -0.8;\n  var legend_label = [\"Placebo\", \"Low Dose\", \"High Dose\"];\n\n  return React.createElement(Plot, {\n    data: [\n      \n  {\n    \"x\": [x[0]],\n    \"y\": [y[0]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[0] - x[0]],\n      arrayminus: [x[0] - 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See the\n * GNU General Public License for more details.\n *\n * You should have received a copy of the GNU General Public License\n * along with this program.  If not, see <http://www.gnu.org/licenses/>.\n *\n */\n\nfunction(cell, state) {\n  const Plot = createPlotlyComponent(Plotly);\n  var x = [cell.row[\"diff_2\"], cell.row[\"diff_3\"]];\n  var y = [1, 2];\n  var x_lower = [cell.row[\"lower_2\"], cell.row[\"lower_3\"]];\n  var x_upper = [cell.row[\"upper_2\"], cell.row[\"upper_3\"]];\n  var x_range = [-20, 47];\n  var y_range = [0, 3];\n  var vline = [];\n  var text = [x[0] + '(' + x_lower[0] + ', ' + x_upper[0] + ')', x[1] + '(' + x_lower[1] + ', ' + x_upper[1] + ')'];\n  var height = 30;\n  var width = 320;\n  var color = [\"rgba(110, 206, 178, 1)\", \"rgba(0, 133, 124, 1)\"];\n  var color_errorbar = [\"rgba(110, 206, 178, 1)\", \"rgba(0, 133, 124, 1)\"];\n  var color_vline = \"rgba(0, 0, 0, 0.313725490196078)\";\n  var margin = [0, 20, 0, 0, 0];\n  var x_label = \"\";\n  var showlegend = false;\n  var legend_title = \"\";\n  var legend_position = 0;\n  var legend_label = [\"\"];\n\n  return React.createElement(Plot, {\n    data: [\n      \n  {\n    \"x\": [x[0]],\n    \"y\": [y[0]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[0] - x[0]],\n      arrayminus: [x[0] - x_lower[0]],\n      \"color\": color_errorbar[0]\n    },\n    \"text\": text[0],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[0],\n    \"marker\": {\n      \"color\": [color[0]],\n      \"line\": {\n          \"color\": color[0]\n      }\n    },\n    \"line\": {\n        \"color\": color[0]\n    }\n  },\n  {\n    \"x\": [x[1]],\n    \"y\": [y[1]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[1] - x[1]],\n      arrayminus: [x[1] - x_lower[1]],\n      \"color\": color_errorbar[1]\n    },\n    \"text\": text[1],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[1],\n    \"marker\": {\n      \"color\": [color[1]],\n      \"line\": {\n          \"color\": color[1]\n      }\n    },\n    \"line\": {\n        \"color\": color[1]\n    }\n  }\n    ],\n    \"layout\": {\n      \"height\": height,\n      \"width\": width,\n      \"margin\": {\n        \"b\": margin[0],\n        \"l\": margin[1],\n        \"t\": margin[2],\n        \"r\": margin[3],\n        \"pad\": margin[4]\n      },\n      \"xaxis\": {\n        \"domain\": [0,1],\n        \"title\": {\n          \"text\": x_label,\n          \"standoff\": 0,\n          \"font\": {\n            \"size\": 12\n          }\n        },\n        \"range\": x_range,\n        \"showline\": true,\n        \"ticks\": \"outside\",\n        \"zeroline\": false,\n        \"fixedrange\": true\n      },\n      \"yaxis\": {\n        \"domain\": [0,1],\n        \"title\": \"\",\n        \"range\": y_range,\n        \"showgrid\": false,\n        \"zeroline\": false,\n        \"showticklabels\": false,\n        \"fixedrange\": true\n      },\n      \"shapes\": [\n        {\n          \"type\": \"line\",\n          \"y0\": y_range[0],\n          \"y1\": y_range[1],\n          \"yref\": \"paper\",\n          \"x0\": vline,\n          \"x1\": vline,\n          \"line\": {\n            \"color\": color_vline\n          }\n        }\n      ],\n      \"plot_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"paper_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"hoverlabel\": {\n        \"bgcolor\": \"lightgray\"\n      },\n      \"showlegend\": showlegend,\n      \"hovermode\": \"closest\",\n      \"legend\": {\n        \"title\": {\n          \"text\": legend_title\n        },\n        \"orientation\": \"h\",\n        \"xanchor\": \"center\",\n        \"x\": 0.5,\n        \"y\": legend_position\n      }\n    },\n    \"config\": {\n      \"showSendToCloud\": false,\n      \"displayModeBar\": false\n    }\n  })\n}","footer":"/*\n * Copyright (c) 2023 Merck & Co., Inc., Rahway, NJ, USA and its affiliates.\n * All rights reserved.\n *\n * This file is part of the forestly program.\n *\n * forestly is free software: you can redistribute it and/or modify\n * it under the terms of the GNU General Public License as published by\n * the Free Software Foundation, either version 3 of the License, or\n * (at your option) any later version.\n *\n * This program is distributed in the hope that it will be useful,\n * but WITHOUT ANY WARRANTY; without even the implied warranty of\n * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the\n * GNU General Public License for more details.\n *\n * You should have received a copy of the GNU General Public License\n * along with this program.  If not, see <http://www.gnu.org/licenses/>.\n *\n */\n\nfunction(cell, state) {\n  const Plot = createPlotlyComponent(Plotly);\n  var x = [1];\n  var y = [-1];\n  var x_lower = [0];\n  var x_upper = [0];\n  var x_range = [-20, 47];\n  var y_range = [0, 2];\n  var vline = [];\n  var text = [\"\"];\n  var height = 90;\n  var width = 320;\n  var color = [\"rgba(255, 215, 0, 1)\"];\n  var color_errorbar = [\"rgba(255, 255, 255, 0)\"];\n  var color_vline = \"rgba(0, 0, 0, 0.313725490196078)\";\n  var margin = [70, 20, 0, 0, 0];\n  var x_label = \"Treatment <- Favor -> Placebo\";\n  var showlegend = false;\n  var legend_title = \"\";\n  var legend_position = 0;\n  var legend_label = [\"\"];\n\n  return React.createElement(Plot, {\n    data: [\n      \n  {\n    \"x\": [x[0]],\n    \"y\": [y[0]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[0] - x[0]],\n      arrayminus: [x[0] - x_lower[0]],\n      \"color\": color_errorbar[0]\n    },\n    \"text\": 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\"yaxis\": {\n        \"domain\": [0,1],\n        \"title\": \"\",\n        \"range\": y_range,\n        \"showgrid\": false,\n        \"zeroline\": false,\n        \"showticklabels\": false,\n        \"fixedrange\": true\n      },\n      \"shapes\": [\n        {\n          \"type\": \"line\",\n          \"y0\": y_range[0],\n          \"y1\": y_range[1],\n          \"yref\": \"paper\",\n          \"x0\": vline,\n          \"x1\": vline,\n          \"line\": {\n            \"color\": color_vline\n          }\n        }\n      ],\n      \"plot_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"paper_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"hoverlabel\": {\n        \"bgcolor\": \"lightgray\"\n      },\n      \"showlegend\": showlegend,\n      \"hovermode\": \"closest\",\n      \"legend\": {\n        \"title\": {\n          \"text\": legend_title\n        },\n        \"orientation\": \"h\",\n        \"xanchor\": \"center\",\n        \"x\": 0.5,\n        \"y\": legend_position\n      }\n    },\n    \"config\": {\n      \"showSendToCloud\": false,\n      \"displayModeBar\": false\n    }\n  })\n}","html":true,"width":320,"align":"center","style":{"font-size":"0px","padding":"0px","margin":"0px"},"footerStyle":{"font-size":"0px","padding":"0px","margin":"0px"},"show":true},{"id":"n_1","name":"n_1","type":"numeric","header":"n","defaultSortDesc":true,"minWidth":40,"align":"center","show":true},{"id":"n_2","name":"n_2","type":"numeric","header":"n","defaultSortDesc":true,"minWidth":40,"align":"center","show":true},{"id":"n_3","name":"n_3","type":"numeric","header":"n","defaultSortDesc":true,"minWidth":40,"align":"center","show":true},{"id":"prop_1","name":"prop_1","type":"numeric","header":"(%)","defaultSortDesc":true,"format":{"cell":{"prefix":"(","suffix":")","digits":1},"aggregated":{"prefix":"(","suffix":")","digits":1}},"minWidth":60,"align":"center","show":true},{"id":"prop_2","name":"prop_2","type":"numeric","header":"(%)","defaultSortDesc":true,"format":{"cell":{"prefix":"(","suffix":")","digits":1},"aggregated":{"prefix":"(","suffix":")","digits":1}},"minWidth":60,"align":"center","show":true},{"id":"prop_3","name":"prop_3","type":"numeric","header":"(%)","defaultSortDesc":true,"format":{"cell":{"prefix":"(","suffix":")","digits":1},"aggregated":{"prefix":"(","suffix":")","digits":1}},"minWidth":60,"align":"center","show":true},{"id":"diff_2","name":"diff_2","type":"numeric","header":"Low 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-<label class="control-label" for="filter_ae_3372|any adverse events">AE Criteria</label>
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peripheral","Pain","Injury, poisoning and procedural complications","Excoriation","Fall","Skin laceration","Wound","Investigations","Blood creatine phosphokinase increased","Body temperature increased","Electrocardiogram st segment depression","Electrocardiogram t wave inversion","Heart rate increased","Heart rate irregular","Metabolism and nutrition disorders","Decreased appetite","Food craving","Increased appetite","Musculoskeletal and connective tissue disorders","Myalgia","Shoulder pain","Nervous system disorders","Balance disorder","Burning sensation","Complex partial seizures","Coordination abnormal","Dizziness","Headache","Hypersomnia","Lethargy","Paraesthesia oral","Parosmia","Somnolence","Stupor","Syncope","Syncope vasovagal","Transient ischaemic attack","Psychiatric disorders","Agitation","Anxiety","Confusional state","Delirium","Depressed mood","Hallucination, visual","Insomnia","Irritability","Libido decreased","Listless","Restlessness","Renal and urinary 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DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","Congenital, familial and genetic disorders","CONGENITAL, FAMILIAL AND GENETIC DISORDERS","Ear and labyrinth disorders","EAR AND LABYRINTH DISORDERS","EAR AND LABYRINTH DISORDERS","EAR AND LABYRINTH DISORDERS","EAR AND LABYRINTH DISORDERS","Eye disorders","EYE DISORDERS","EYE DISORDERS","EYE DISORDERS","EYE DISORDERS","EYE DISORDERS","EYE DISORDERS","EYE DISORDERS","Gastrointestinal disorders","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","General disorders and administration site conditions","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","Hepatobiliary disorders","HEPATOBILIARY DISORDERS","Immune system disorders","IMMUNE SYSTEM DISORDERS","IMMUNE SYSTEM DISORDERS","Infections and infestations","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","Injury, poisoning and procedural complications","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","Investigations","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","Metabolism and nutrition disorders","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","Musculoskeletal and connective tissue disorders","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","Neoplasms benign, malignant and unspecified (incl cysts and polyps)","NEOPLASMS BENIGN, MALIGNANT AND UNSPECIFIED (INCL CYSTS AND POLYPS)","NEOPLASMS BENIGN, MALIGNANT AND UNSPECIFIED (INCL CYSTS AND POLYPS)","NEOPLASMS BENIGN, MALIGNANT AND UNSPECIFIED (INCL CYSTS AND POLYPS)","Nervous system disorders","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","Psychiatric disorders","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","Renal and urinary disorders","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","Reproductive system and breast disorders","REPRODUCTIVE SYSTEM AND BREAST DISORDERS","REPRODUCTIVE SYSTEM AND BREAST DISORDERS","Respiratory, thoracic and mediastinal disorders","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","Skin and subcutaneous tissue disorders","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","Social circumstances","SOCIAL CIRCUMSTANCES","Surgical and medical procedures","SURGICAL AND MEDICAL PROCEDURES","SURGICAL AND MEDICAL PROCEDURES","SURGICAL AND MEDICAL PROCEDURES","SURGICAL AND MEDICAL PROCEDURES","Vascular disorders","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","Cardiac disorders","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","Congenital, familial and genetic disorders","CONGENITAL, FAMILIAL AND GENETIC DISORDERS","Ear and labyrinth disorders","EAR AND LABYRINTH DISORDERS","EAR AND LABYRINTH DISORDERS","Eye disorders","EYE DISORDERS","Gastrointestinal disorders","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","General disorders and administration site conditions","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","Injury, poisoning and procedural complications","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","Investigations","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","Metabolism and nutrition disorders","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","Musculoskeletal and connective tissue disorders","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","Nervous system disorders","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","Psychiatric disorders","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","Renal and urinary disorders","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","Reproductive system and breast disorders","REPRODUCTIVE SYSTEM AND BREAST DISORDERS","Respiratory, thoracic and mediastinal disorders","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","Skin and subcutaneous tissue disorders","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","Vascular disorders","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","Nervous system disorders","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM 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If not, see <http://www.gnu.org/licenses/>.\n *\n */\n\nfunction(cell, state) {\n  const Plot = createPlotlyComponent(Plotly);\n  var x = [cell.row[\"prop_1\"], cell.row[\"prop_2\"], cell.row[\"prop_3\"]];\n  var y = [1.5, 1, 2];\n  var x_lower = [0];\n  var x_upper = [0];\n  var x_range = [-2, 58];\n  var y_range = [0, 4];\n  var vline = [];\n  var text = [x[0], x[1], x[2]];\n  var height = 30;\n  var width = 230;\n  var color = [\"rgba(102, 32, 58, 1)\", \"rgba(110, 206, 178, 1)\", \"rgba(0, 133, 124, 1)\"];\n  var color_errorbar = [\"rgba(255, 255, 255, 0)\"];\n  var color_vline = \"rgba(0, 0, 0, 0.313725490196078)\";\n  var margin = [0, 0, 0, 0, 0];\n  var x_label = \"\";\n  var showlegend = false;\n  var legend_title = \"\";\n  var legend_position = 0;\n  var legend_label = [\"\"];\n\n  return React.createElement(Plot, {\n    data: [\n      \n  {\n    \"x\": [x[0]],\n    \"y\": [y[0]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[0] - x[0]],\n      arrayminus: [x[0] - x_lower[0]],\n      \"color\": color_errorbar[0]\n    },\n    \"text\": text[0],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[0],\n    \"marker\": {\n      \"color\": [color[0]],\n      \"line\": {\n          \"color\": color[0]\n      }\n    },\n    \"line\": {\n        \"color\": color[0]\n    }\n  },\n  {\n    \"x\": [x[1]],\n    \"y\": [y[1]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[1] - x[1]],\n      arrayminus: [x[1] - x_lower[1]],\n      \"color\": color_errorbar[1]\n    },\n    \"text\": text[1],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[1],\n    \"marker\": {\n      \"color\": [color[1]],\n      \"line\": {\n          \"color\": color[1]\n      }\n    },\n    \"line\": {\n        \"color\": color[1]\n    }\n  },\n  {\n    \"x\": [x[2]],\n    \"y\": [y[2]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[2] - x[2]],\n      arrayminus: [x[2] - x_lower[2]],\n      \"color\": color_errorbar[2]\n    },\n    \"text\": text[2],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[2],\n    \"marker\": {\n      \"color\": [color[2]],\n      \"line\": {\n          \"color\": color[2]\n      }\n    },\n    \"line\": {\n        \"color\": color[2]\n    }\n  }\n    ],\n    \"layout\": {\n      \"height\": height,\n      \"width\": width,\n      \"margin\": {\n        \"b\": margin[0],\n        \"l\": margin[1],\n        \"t\": margin[2],\n        \"r\": margin[3],\n        \"pad\": margin[4]\n      },\n      \"xaxis\": {\n        \"domain\": [0,1],\n        \"title\": {\n          \"text\": x_label,\n          \"standoff\": 0,\n          \"font\": {\n            \"size\": 12\n          }\n        },\n        \"range\": x_range,\n        \"showline\": true,\n        \"ticks\": \"outside\",\n        \"zeroline\": false,\n        \"fixedrange\": true\n      },\n      \"yaxis\": {\n        \"domain\": [0,1],\n        \"title\": \"\",\n        \"range\": y_range,\n        \"showgrid\": false,\n        \"zeroline\": false,\n        \"showticklabels\": false,\n        \"fixedrange\": true\n      },\n      \"shapes\": [\n        {\n          \"type\": \"line\",\n          \"y0\": y_range[0],\n          \"y1\": y_range[1],\n          \"yref\": \"paper\",\n          \"x0\": vline,\n          \"x1\": vline,\n          \"line\": {\n            \"color\": color_vline\n          }\n        }\n      ],\n      \"plot_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"paper_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"hoverlabel\": {\n        \"bgcolor\": \"lightgray\"\n      },\n      \"showlegend\": showlegend,\n      \"hovermode\": \"closest\",\n      \"legend\": {\n        \"title\": {\n          \"text\": legend_title\n        },\n        \"orientation\": \"h\",\n        \"xanchor\": \"center\",\n        \"x\": 0.5,\n        \"y\": legend_position\n      }\n    },\n    \"config\": {\n      \"showSendToCloud\": false,\n      \"displayModeBar\": false\n    }\n  })\n}","footer":"/*\n * Copyright (c) 2023 Merck & Co., Inc., Rahway, NJ, USA and its affiliates.\n * All rights reserved.\n *\n * This file is part of the forestly program.\n *\n * forestly is free software: you can redistribute it and/or modify\n * it under the terms of the GNU General Public License as published by\n * the Free Software Foundation, either version 3 of the License, or\n * (at your option) any later version.\n *\n * This program is distributed in the hope that it will be useful,\n * but WITHOUT ANY WARRANTY; without even the implied warranty of\n * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the\n * GNU General Public License for more details.\n *\n * You should have received a copy of the GNU General Public License\n * along with this program.  If not, see <http://www.gnu.org/licenses/>.\n *\n */\n\nfunction(cell, state) {\n  const Plot = createPlotlyComponent(Plotly);\n  var x = [1, 2, 3];\n  var y = [-1, -1, -1];\n  var x_lower = [0];\n  var x_upper = [0];\n  var x_range = [-2, 58];\n  var y_range = [0, 4];\n  var vline = [];\n  var text = [\"\", \"\", \"\"];\n  var height = 110;\n  var width = 230;\n  var color = [\"rgba(102, 32, 58, 1)\", \"rgba(110, 206, 178, 1)\", \"rgba(0, 133, 124, 1)\"];\n  var color_errorbar = [\"rgba(255, 255, 255, 0)\"];\n  var color_vline = \"rgba(0, 0, 0, 0.313725490196078)\";\n  var margin = [90, 0, 0, 0, 0];\n  var x_label = \"\";\n  var showlegend = true;\n  var legend_title = \"\";\n  var legend_position = -0.8;\n  var legend_label = [\"Placebo\", \"Low Dose\", \"High Dose\"];\n\n  return React.createElement(Plot, {\n    data: [\n      \n  {\n    \"x\": [x[0]],\n    \"y\": [y[0]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[0] - x[0]],\n      arrayminus: [x[0] - 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See the\n * GNU General Public License for more details.\n *\n * You should have received a copy of the GNU General Public License\n * along with this program.  If not, see <http://www.gnu.org/licenses/>.\n *\n */\n\nfunction(cell, state) {\n  const Plot = createPlotlyComponent(Plotly);\n  var x = [cell.row[\"diff_2\"], cell.row[\"diff_3\"]];\n  var y = [1, 2];\n  var x_lower = [cell.row[\"lower_2\"], cell.row[\"lower_3\"]];\n  var x_upper = [cell.row[\"upper_2\"], cell.row[\"upper_3\"]];\n  var x_range = [-20, 47];\n  var y_range = [0, 3];\n  var vline = [];\n  var text = [x[0] + '(' + x_lower[0] + ', ' + x_upper[0] + ')', x[1] + '(' + x_lower[1] + ', ' + x_upper[1] + ')'];\n  var height = 30;\n  var width = 230;\n  var color = [\"rgba(110, 206, 178, 1)\", \"rgba(0, 133, 124, 1)\"];\n  var color_errorbar = [\"rgba(110, 206, 178, 1)\", \"rgba(0, 133, 124, 1)\"];\n  var color_vline = \"rgba(0, 0, 0, 0.313725490196078)\";\n  var margin = [0, 20, 0, 0, 0];\n  var x_label = \"\";\n  var showlegend = false;\n  var legend_title = \"\";\n  var legend_position = 0;\n  var legend_label = [\"\"];\n\n  return React.createElement(Plot, {\n    data: [\n      \n  {\n    \"x\": [x[0]],\n    \"y\": [y[0]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[0] - x[0]],\n      arrayminus: [x[0] - x_lower[0]],\n      \"color\": color_errorbar[0]\n    },\n    \"text\": text[0],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[0],\n    \"marker\": {\n      \"color\": [color[0]],\n      \"line\": {\n          \"color\": color[0]\n      }\n    },\n    \"line\": {\n        \"color\": color[0]\n    }\n  },\n  {\n    \"x\": [x[1]],\n    \"y\": [y[1]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[1] - x[1]],\n      arrayminus: [x[1] - x_lower[1]],\n      \"color\": color_errorbar[1]\n    },\n    \"text\": text[1],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[1],\n    \"marker\": {\n      \"color\": [color[1]],\n      \"line\": {\n          \"color\": color[1]\n      }\n    },\n    \"line\": {\n        \"color\": color[1]\n    }\n  }\n    ],\n    \"layout\": {\n      \"height\": height,\n      \"width\": width,\n      \"margin\": {\n        \"b\": margin[0],\n        \"l\": margin[1],\n        \"t\": margin[2],\n        \"r\": margin[3],\n        \"pad\": margin[4]\n      },\n      \"xaxis\": {\n        \"domain\": [0,1],\n        \"title\": {\n          \"text\": x_label,\n          \"standoff\": 0,\n          \"font\": {\n            \"size\": 12\n          }\n        },\n        \"range\": x_range,\n        \"showline\": true,\n        \"ticks\": \"outside\",\n        \"zeroline\": false,\n        \"fixedrange\": true\n      },\n      \"yaxis\": {\n        \"domain\": [0,1],\n        \"title\": \"\",\n        \"range\": y_range,\n        \"showgrid\": false,\n        \"zeroline\": false,\n        \"showticklabels\": false,\n        \"fixedrange\": true\n      },\n      \"shapes\": [\n        {\n          \"type\": \"line\",\n          \"y0\": y_range[0],\n          \"y1\": y_range[1],\n          \"yref\": \"paper\",\n          \"x0\": vline,\n          \"x1\": vline,\n          \"line\": {\n            \"color\": color_vline\n          }\n        }\n      ],\n      \"plot_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"paper_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"hoverlabel\": {\n        \"bgcolor\": \"lightgray\"\n      },\n      \"showlegend\": showlegend,\n      \"hovermode\": \"closest\",\n      \"legend\": {\n        \"title\": {\n          \"text\": legend_title\n        },\n        \"orientation\": \"h\",\n        \"xanchor\": \"center\",\n        \"x\": 0.5,\n        \"y\": legend_position\n      }\n    },\n    \"config\": {\n      \"showSendToCloud\": false,\n      \"displayModeBar\": false\n    }\n  })\n}","footer":"/*\n * Copyright (c) 2023 Merck & Co., Inc., Rahway, NJ, USA and its affiliates.\n * All rights reserved.\n *\n * This file is part of the forestly program.\n *\n * forestly is free software: you can redistribute it and/or modify\n * it under the terms of the GNU General Public License as published by\n * the Free Software Foundation, either version 3 of the License, or\n * (at your option) any later version.\n *\n * This program is distributed in the hope that it will be useful,\n * but WITHOUT ANY WARRANTY; without even the implied warranty of\n * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the\n * GNU General Public License for more details.\n *\n * You should have received a copy of the GNU General Public License\n * along with this program.  If not, see <http://www.gnu.org/licenses/>.\n *\n */\n\nfunction(cell, state) {\n  const Plot = createPlotlyComponent(Plotly);\n  var x = [1];\n  var y = [-1];\n  var x_lower = [0];\n  var x_upper = [0];\n  var x_range = [-20, 47];\n  var y_range = [0, 2];\n  var vline = [];\n  var text = [\"\"];\n  var height = 110;\n  var width = 230;\n  var color = [\"rgba(255, 215, 0, 1)\"];\n  var color_errorbar = [\"rgba(255, 255, 255, 0)\"];\n  var color_vline = \"rgba(0, 0, 0, 0.313725490196078)\";\n  var margin = [90, 20, 0, 0, 0];\n  var x_label = \"Treatment <- Favor -> Placebo\";\n  var showlegend = false;\n  var legend_title = \"\";\n  var legend_position = 0;\n  var legend_label = [\"\"];\n\n  return React.createElement(Plot, {\n    data: [\n      \n  {\n    \"x\": [x[0]],\n    \"y\": [y[0]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[0] - x[0]],\n      arrayminus: [x[0] - x_lower[0]],\n      \"color\": color_errorbar[0]\n    },\n    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})\n}","html":true,"width":230,"align":"center","style":{"font-size":"0px","padding":"0px","margin":"0px"},"footerStyle":{"font-size":"0px","padding":"0px","margin":"0px"},"show":true},{"id":"n_1","name":"n_1","type":"numeric","header":"n","defaultSortDesc":true,"minWidth":40,"align":"center","show":true},{"id":"n_2","name":"n_2","type":"numeric","header":"n","defaultSortDesc":true,"minWidth":40,"align":"center","show":true},{"id":"n_3","name":"n_3","type":"numeric","header":"n","defaultSortDesc":true,"minWidth":40,"align":"center","show":true},{"id":"prop_1","name":"prop_1","type":"numeric","header":"(%)","defaultSortDesc":true,"format":{"cell":{"prefix":"(","suffix":")","digits":1},"aggregated":{"prefix":"(","suffix":")","digits":1}},"minWidth":60,"align":"center","show":true},{"id":"prop_2","name":"prop_2","type":"numeric","header":"(%)","defaultSortDesc":true,"format":{"cell":{"prefix":"(","suffix":")","digits":1},"aggregated":{"prefix":"(","suffix":")","digits":1}},"minWidth":60,"align":"center","show":true},{"id":"prop_3","name":"prop_3","type":"numeric","header":"(%)","defaultSortDesc":true,"format":{"cell":{"prefix":"(","suffix":")","digits":1},"aggregated":{"prefix":"(","suffix":")","digits":1}},"minWidth":60,"align":"center","show":true},{"id":"diff_2","name":"diff_2","type":"numeric","header":"Low 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@@ -409,20 +425,20 @@ <h2 id="change-variable-listed-in-drill-down-table">Change variable listed in dr
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-<div id="filter_ae_3332|any adverse events" class="form-group crosstalk-input-select crosstalk-input">
-<label class="control-label" for="filter_ae_3332|any adverse events">AE Criteria</label>
+<div id="filter_ae_34bff287-4e46-450e-80fb-5c0c2a11eea8|any adverse events" class="form-group crosstalk-input-select crosstalk-input">
+<label class="control-label" for="filter_ae_34bff287-4e46-450e-80fb-5c0c2a11eea8|any adverse events">AE Criteria</label>
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subcutaneous tissue disorders","Actinic keratosis","Alopecia","Blister","Cold sweat","Dermatitis atopic","Dermatitis contact","Drug eruption","Erythema","Hyperhidrosis","Pruritus","Pruritus generalised","Rash","Rash erythematous","Rash maculo-papular","Rash papular","Rash pruritic","Skin exfoliation","Skin irritation","Skin odour abnormal","Skin ulcer","Urticaria","Social circumstances","Alcohol use","Surgical and medical procedures","Acrochordon excision","Cataract operation","Eye laser surgery","Skin lesion excision","Vascular disorders","Hot flush","Hypertension","Hypotension","Orthostatic hypotension","Wound haemorrhage","Cardiac disorders","Atrial fibrillation","Atrial flutter","Atrioventricular block first degree","Atrioventricular block second degree","Bradycardia","Bundle branch block right","Cardiac failure congestive","Myocardial infarction","Palpitations","Sinus arrhythmia","Sinus bradycardia","Supraventricular extrasystoles","Ventricular extrasystoles","Wolff-parkinson-white syndrome","Congenital, familial and genetic disorders","Ventricular septal defect","Ear and labyrinth disorders","Tinnitus","Vertigo","Eye disorders","Vision blurred","Gastrointestinal disorders","Abdominal pain","Diarrhoea","Dyspepsia","Gastrooesophageal reflux disease","Nausea","Salivary hypersecretion","Stomach discomfort","Vomiting","General disorders and administration site conditions","Application site bleeding","Application site dermatitis","Application site desquamation","Application site discharge","Application site discolouration","Application site erythema","Application site induration","Application site irritation","Application site pain","Application site perspiration","Application site pruritus","Application site reaction","Application site swelling","Application site urticaria","Application site vesicles","Application site warmth","Asthenia","Chest discomfort","Chills","Fatigue","Feeling abnormal","Malaise","Oedema","Oedema peripheral","Pain","Injury, poisoning and procedural complications","Excoriation","Fall","Skin laceration","Wound","Investigations","Blood creatine phosphokinase increased","Body temperature increased","Electrocardiogram st segment depression","Electrocardiogram t wave inversion","Heart rate increased","Heart rate irregular","Metabolism and nutrition disorders","Decreased appetite","Food craving","Increased appetite","Musculoskeletal and connective tissue disorders","Myalgia","Shoulder pain","Nervous system disorders","Balance disorder","Burning sensation","Complex partial seizures","Coordination abnormal","Dizziness","Headache","Hypersomnia","Lethargy","Paraesthesia oral","Parosmia","Somnolence","Stupor","Syncope","Syncope vasovagal","Transient ischaemic attack","Psychiatric disorders","Agitation","Anxiety","Confusional state","Delirium","Depressed mood","Hallucination, visual","Insomnia","Irritability","Libido decreased","Listless","Restlessness","Renal and urinary disorders","Enuresis","Micturition urgency","Reproductive system and breast disorders","Pelvic pain","Respiratory, thoracic and mediastinal disorders","Dyspnoea","Emphysema","Skin and subcutaneous tissue disorders","Blister","Cold sweat","Dermatitis contact","Erythema","Hyperhidrosis","Pruritus","Pruritus generalised","Rash","Rash erythematous","Rash maculo-papular","Rash papular","Rash pruritic","Skin exfoliation","Skin irritation","Skin ulcer","Urticaria","Vascular disorders","Hypertension","Hypotension","Orthostatic hypotension","Wound haemorrhage","Nervous system disorders","Partial seizures with secondary generalisation","Syncope"],"soc_name":["Cardiac disorders","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","Congenital, familial and genetic disorders","CONGENITAL, FAMILIAL AND GENETIC DISORDERS","Ear and labyrinth disorders","EAR AND LABYRINTH DISORDERS","EAR AND LABYRINTH DISORDERS","EAR AND LABYRINTH DISORDERS","EAR AND LABYRINTH DISORDERS","Eye disorders","EYE DISORDERS","EYE DISORDERS","EYE DISORDERS","EYE DISORDERS","EYE DISORDERS","EYE DISORDERS","EYE DISORDERS","Gastrointestinal disorders","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","General disorders and administration site conditions","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","Hepatobiliary disorders","HEPATOBILIARY DISORDERS","Immune system disorders","IMMUNE SYSTEM DISORDERS","IMMUNE SYSTEM DISORDERS","Infections and infestations","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","INFECTIONS AND INFESTATIONS","Injury, poisoning and procedural complications","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","Investigations","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","Metabolism and nutrition disorders","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","Musculoskeletal and connective tissue disorders","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","Neoplasms benign, malignant and unspecified (incl cysts and polyps)","NEOPLASMS BENIGN, MALIGNANT AND UNSPECIFIED (INCL CYSTS AND POLYPS)","NEOPLASMS BENIGN, MALIGNANT AND UNSPECIFIED (INCL CYSTS AND POLYPS)","NEOPLASMS BENIGN, MALIGNANT AND UNSPECIFIED (INCL CYSTS AND POLYPS)","Nervous system disorders","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","Psychiatric disorders","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","Renal and urinary disorders","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","Reproductive system and breast disorders","REPRODUCTIVE SYSTEM AND BREAST DISORDERS","REPRODUCTIVE SYSTEM AND BREAST DISORDERS","Respiratory, thoracic and mediastinal disorders","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","Skin and subcutaneous tissue disorders","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","Social circumstances","SOCIAL CIRCUMSTANCES","Surgical and medical procedures","SURGICAL AND MEDICAL PROCEDURES","SURGICAL AND MEDICAL PROCEDURES","SURGICAL AND MEDICAL PROCEDURES","SURGICAL AND MEDICAL PROCEDURES","Vascular disorders","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","Cardiac disorders","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","CARDIAC DISORDERS","Congenital, familial and genetic disorders","CONGENITAL, FAMILIAL AND GENETIC DISORDERS","Ear and labyrinth disorders","EAR AND LABYRINTH DISORDERS","EAR AND LABYRINTH DISORDERS","Eye disorders","EYE DISORDERS","Gastrointestinal disorders","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","GASTROINTESTINAL DISORDERS","General disorders and administration site conditions","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS","Injury, poisoning and procedural complications","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","INJURY, POISONING AND PROCEDURAL COMPLICATIONS","Investigations","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","INVESTIGATIONS","Metabolism and nutrition disorders","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","METABOLISM AND NUTRITION DISORDERS","Musculoskeletal and connective tissue disorders","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS","Nervous system disorders","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM DISORDERS","Psychiatric disorders","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","PSYCHIATRIC DISORDERS","Renal and urinary disorders","RENAL AND URINARY DISORDERS","RENAL AND URINARY DISORDERS","Reproductive system and breast disorders","REPRODUCTIVE SYSTEM AND BREAST DISORDERS","Respiratory, thoracic and mediastinal disorders","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","RESPIRATORY, THORACIC AND MEDIASTINAL DISORDERS","Skin and subcutaneous tissue disorders","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","SKIN AND SUBCUTANEOUS TISSUE DISORDERS","Vascular disorders","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","VASCULAR DISORDERS","Nervous system disorders","NERVOUS SYSTEM DISORDERS","NERVOUS SYSTEM 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See the\n * GNU General Public License for more details.\n *\n * You should have received a copy of the GNU General Public License\n * along with this program.  If not, see <http://www.gnu.org/licenses/>.\n *\n */\n\nfunction(cell, state) {\n  const Plot = createPlotlyComponent(Plotly);\n  var x = [cell.row[\"prop_1\"], cell.row[\"prop_2\"], cell.row[\"prop_3\"]];\n  var y = [1.5, 1, 2];\n  var x_lower = [0];\n  var x_upper = [0];\n  var x_range = [-2, 58];\n  var y_range = [0, 4];\n  var vline = [];\n  var text = [x[0], x[1], x[2]];\n  var height = 30;\n  var width = 320;\n  var color = [\"rgba(102, 32, 58, 1)\", \"rgba(110, 206, 178, 1)\", \"rgba(0, 133, 124, 1)\"];\n  var color_errorbar = [\"rgba(255, 255, 255, 0)\"];\n  var color_vline = \"rgba(0, 0, 0, 0.313725490196078)\";\n  var margin = [0, 0, 0, 0, 0];\n  var x_label = \"\";\n  var showlegend = false;\n  var legend_title = \"\";\n  var legend_position = 0;\n  var legend_label = [\"\"];\n\n  return React.createElement(Plot, {\n    data: [\n      \n  {\n    \"x\": [x[0]],\n    \"y\": [y[0]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[0] - x[0]],\n      arrayminus: [x[0] - x_lower[0]],\n      \"color\": color_errorbar[0]\n    },\n    \"text\": text[0],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[0],\n    \"marker\": {\n      \"color\": [color[0]],\n      \"line\": {\n          \"color\": color[0]\n      }\n    },\n    \"line\": {\n        \"color\": color[0]\n    }\n  },\n  {\n    \"x\": [x[1]],\n    \"y\": [y[1]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[1] - x[1]],\n      arrayminus: [x[1] - x_lower[1]],\n      \"color\": color_errorbar[1]\n    },\n    \"text\": text[1],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[1],\n    \"marker\": {\n      \"color\": [color[1]],\n      \"line\": {\n          \"color\": color[1]\n      }\n    },\n    \"line\": {\n        \"color\": color[1]\n    }\n  },\n  {\n    \"x\": [x[2]],\n    \"y\": [y[2]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[2] - x[2]],\n      arrayminus: [x[2] - x_lower[2]],\n      \"color\": color_errorbar[2]\n    },\n    \"text\": text[2],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[2],\n    \"marker\": {\n      \"color\": [color[2]],\n      \"line\": {\n          \"color\": color[2]\n      }\n    },\n    \"line\": {\n        \"color\": color[2]\n    }\n  }\n    ],\n    \"layout\": {\n      \"height\": height,\n      \"width\": width,\n      \"margin\": {\n        \"b\": margin[0],\n        \"l\": margin[1],\n        \"t\": margin[2],\n        \"r\": margin[3],\n        \"pad\": margin[4]\n      },\n      \"xaxis\": {\n        \"domain\": [0,1],\n        \"title\": {\n          \"text\": x_label,\n          \"standoff\": 0,\n          \"font\": {\n            \"size\": 12\n          }\n        },\n        \"range\": x_range,\n        \"showline\": true,\n        \"ticks\": \"outside\",\n        \"zeroline\": false,\n        \"fixedrange\": true\n      },\n      \"yaxis\": {\n        \"domain\": [0,1],\n        \"title\": \"\",\n        \"range\": y_range,\n        \"showgrid\": false,\n        \"zeroline\": false,\n        \"showticklabels\": false,\n        \"fixedrange\": true\n      },\n      \"shapes\": [\n        {\n          \"type\": \"line\",\n          \"y0\": y_range[0],\n          \"y1\": y_range[1],\n          \"yref\": \"paper\",\n          \"x0\": vline,\n          \"x1\": vline,\n          \"line\": {\n            \"color\": color_vline\n          }\n        }\n      ],\n      \"plot_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"paper_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"hoverlabel\": {\n        \"bgcolor\": \"lightgray\"\n      },\n      \"showlegend\": showlegend,\n      \"hovermode\": \"closest\",\n      \"legend\": {\n        \"title\": {\n          \"text\": legend_title\n        },\n        \"orientation\": \"h\",\n        \"xanchor\": \"center\",\n        \"x\": 0.5,\n        \"y\": legend_position\n      }\n    },\n    \"config\": {\n      \"showSendToCloud\": false,\n      \"displayModeBar\": false\n    }\n  })\n}","footer":"/*\n * Copyright (c) 2023 Merck & Co., Inc., Rahway, NJ, USA and its affiliates.\n * All rights reserved.\n *\n * This file is part of the forestly program.\n *\n * forestly is free software: you can redistribute it and/or modify\n * it under the terms of the GNU General Public License as published by\n * the Free Software Foundation, either version 3 of the License, or\n * (at your option) any later version.\n *\n * This program is distributed in the hope that it will be useful,\n * but WITHOUT ANY WARRANTY; without even the implied warranty of\n * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the\n * GNU General Public License for more details.\n *\n * You should have received a copy of the GNU General Public License\n * along with this program.  If not, see <http://www.gnu.org/licenses/>.\n *\n */\n\nfunction(cell, state) {\n  const Plot = createPlotlyComponent(Plotly);\n  var x = [1, 2, 3];\n  var y = [-1, -1, -1];\n  var x_lower = [0];\n  var x_upper = [0];\n  var x_range = [-2, 58];\n  var y_range = [0, 4];\n  var vline = [];\n  var text = [\"\", \"\", \"\"];\n  var height = 90;\n  var width = 320;\n  var color = [\"rgba(102, 32, 58, 1)\", \"rgba(110, 206, 178, 1)\", \"rgba(0, 133, 124, 1)\"];\n  var color_errorbar = [\"rgba(255, 255, 255, 0)\"];\n  var color_vline = \"rgba(0, 0, 0, 0.313725490196078)\";\n  var margin = [70, 0, 0, 0, 0];\n  var x_label = \"\";\n  var showlegend = true;\n  var legend_title = \"\";\n  var legend_position = -0.8;\n  var legend_label = [\"Placebo\", \"Low Dose\", \"High Dose\"];\n\n  return React.createElement(Plot, {\n    data: [\n      \n  {\n    \"x\": [x[0]],\n    \"y\": [y[0]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[0] - x[0]],\n      arrayminus: [x[0] - 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See the\n * GNU General Public License for more details.\n *\n * You should have received a copy of the GNU General Public License\n * along with this program.  If not, see <http://www.gnu.org/licenses/>.\n *\n */\n\nfunction(cell, state) {\n  const Plot = createPlotlyComponent(Plotly);\n  var x = [cell.row[\"diff_2\"], cell.row[\"diff_3\"]];\n  var y = [1, 2];\n  var x_lower = [cell.row[\"lower_2\"], cell.row[\"lower_3\"]];\n  var x_upper = [cell.row[\"upper_2\"], cell.row[\"upper_3\"]];\n  var x_range = [-20, 47];\n  var y_range = [0, 3];\n  var vline = [];\n  var text = [x[0] + '(' + x_lower[0] + ', ' + x_upper[0] + ')', x[1] + '(' + x_lower[1] + ', ' + x_upper[1] + ')'];\n  var height = 30;\n  var width = 320;\n  var color = [\"rgba(110, 206, 178, 1)\", \"rgba(0, 133, 124, 1)\"];\n  var color_errorbar = [\"rgba(110, 206, 178, 1)\", \"rgba(0, 133, 124, 1)\"];\n  var color_vline = \"rgba(0, 0, 0, 0.313725490196078)\";\n  var margin = [0, 20, 0, 0, 0];\n  var x_label = \"\";\n  var showlegend = false;\n  var legend_title = \"\";\n  var legend_position = 0;\n  var legend_label = [\"\"];\n\n  return React.createElement(Plot, {\n    data: [\n      \n  {\n    \"x\": [x[0]],\n    \"y\": [y[0]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[0] - x[0]],\n      arrayminus: [x[0] - x_lower[0]],\n      \"color\": color_errorbar[0]\n    },\n    \"text\": text[0],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[0],\n    \"marker\": {\n      \"color\": [color[0]],\n      \"line\": {\n          \"color\": color[0]\n      }\n    },\n    \"line\": {\n        \"color\": color[0]\n    }\n  },\n  {\n    \"x\": [x[1]],\n    \"y\": [y[1]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[1] - x[1]],\n      arrayminus: [x[1] - x_lower[1]],\n      \"color\": color_errorbar[1]\n    },\n    \"text\": text[1],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[1],\n    \"marker\": {\n      \"color\": [color[1]],\n      \"line\": {\n          \"color\": color[1]\n      }\n    },\n    \"line\": {\n        \"color\": color[1]\n    }\n  }\n    ],\n    \"layout\": {\n      \"height\": height,\n      \"width\": width,\n      \"margin\": {\n        \"b\": margin[0],\n        \"l\": margin[1],\n        \"t\": margin[2],\n        \"r\": margin[3],\n        \"pad\": margin[4]\n      },\n      \"xaxis\": {\n        \"domain\": [0,1],\n        \"title\": {\n          \"text\": x_label,\n          \"standoff\": 0,\n          \"font\": {\n            \"size\": 12\n          }\n        },\n        \"range\": x_range,\n        \"showline\": true,\n        \"ticks\": \"outside\",\n        \"zeroline\": false,\n        \"fixedrange\": true\n      },\n      \"yaxis\": {\n        \"domain\": [0,1],\n        \"title\": \"\",\n        \"range\": y_range,\n        \"showgrid\": false,\n        \"zeroline\": false,\n        \"showticklabels\": false,\n        \"fixedrange\": true\n      },\n      \"shapes\": [\n        {\n          \"type\": \"line\",\n          \"y0\": y_range[0],\n          \"y1\": y_range[1],\n          \"yref\": \"paper\",\n          \"x0\": vline,\n          \"x1\": vline,\n          \"line\": {\n            \"color\": color_vline\n          }\n        }\n      ],\n      \"plot_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"paper_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"hoverlabel\": {\n        \"bgcolor\": \"lightgray\"\n      },\n      \"showlegend\": showlegend,\n      \"hovermode\": \"closest\",\n      \"legend\": {\n        \"title\": {\n          \"text\": legend_title\n        },\n        \"orientation\": \"h\",\n        \"xanchor\": \"center\",\n        \"x\": 0.5,\n        \"y\": legend_position\n      }\n    },\n    \"config\": {\n      \"showSendToCloud\": false,\n      \"displayModeBar\": false\n    }\n  })\n}","footer":"/*\n * Copyright (c) 2023 Merck & Co., Inc., Rahway, NJ, USA and its affiliates.\n * All rights reserved.\n *\n * This file is part of the forestly program.\n *\n * forestly is free software: you can redistribute it and/or modify\n * it under the terms of the GNU General Public License as published by\n * the Free Software Foundation, either version 3 of the License, or\n * (at your option) any later version.\n *\n * This program is distributed in the hope that it will be useful,\n * but WITHOUT ANY WARRANTY; without even the implied warranty of\n * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the\n * GNU General Public License for more details.\n *\n * You should have received a copy of the GNU General Public License\n * along with this program.  If not, see <http://www.gnu.org/licenses/>.\n *\n */\n\nfunction(cell, state) {\n  const Plot = createPlotlyComponent(Plotly);\n  var x = [1];\n  var y = [-1];\n  var x_lower = [0];\n  var x_upper = [0];\n  var x_range = [-20, 47];\n  var y_range = [0, 2];\n  var vline = [];\n  var text = [\"\"];\n  var height = 90;\n  var width = 320;\n  var color = [\"rgba(255, 215, 0, 1)\"];\n  var color_errorbar = [\"rgba(255, 255, 255, 0)\"];\n  var color_vline = \"rgba(0, 0, 0, 0.313725490196078)\";\n  var margin = [70, 20, 0, 0, 0];\n  var x_label = \"Treatment <- Favor -> Placebo\";\n  var showlegend = false;\n  var legend_title = \"\";\n  var legend_position = 0;\n  var legend_label = [\"\"];\n\n  return React.createElement(Plot, {\n    data: [\n      \n  {\n    \"x\": [x[0]],\n    \"y\": [y[0]],\n   \"error_x\": {\n      type: \"data\",\n      symmetric: false,\n      array: [x_upper[0] - x[0]],\n      arrayminus: [x[0] - x_lower[0]],\n      \"color\": color_errorbar[0]\n    },\n    \"text\": text[0],\n    \"hoverinfo\": \"text\",\n    \"mode\": \"markers\",\n    \"alpha_stroke\": 1,\n    \"sizes\": [10, 100],\n    \"spans\": [1, 20],\n    \"type\": \"scatter\",\n    \"name\": legend_label[0],\n    \"marker\": {\n      \"color\": [color[0]],\n      \"line\": {\n          \"color\": color[0]\n      }\n    },\n    \"line\": {\n        \"color\": color[0]\n    }\n  }\n    ],\n    \"layout\": {\n      \"height\": height,\n      \"width\": width,\n      \"margin\": {\n        \"b\": margin[0],\n        \"l\": margin[1],\n        \"t\": margin[2],\n        \"r\": margin[3],\n        \"pad\": margin[4]\n      },\n      \"xaxis\": {\n        \"domain\": [0,1],\n        \"title\": {\n          \"text\": x_label,\n          \"standoff\": 0,\n          \"font\": {\n            \"size\": 12\n          }\n        },\n        \"range\": x_range,\n        \"showline\": true,\n        \"ticks\": \"outside\",\n        \"zeroline\": false,\n        \"fixedrange\": true\n      },\n      \"yaxis\": {\n        \"domain\": [0,1],\n        \"title\": \"\",\n        \"range\": y_range,\n        \"showgrid\": false,\n        \"zeroline\": false,\n        \"showticklabels\": false,\n        \"fixedrange\": true\n      },\n      \"shapes\": [\n        {\n          \"type\": \"line\",\n          \"y0\": y_range[0],\n          \"y1\": y_range[1],\n          \"yref\": \"paper\",\n          \"x0\": vline,\n          \"x1\": vline,\n          \"line\": {\n            \"color\": color_vline\n          }\n        }\n      ],\n      \"plot_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"paper_bgcolor\": \"rgba(0, 0, 0, 0)\",\n      \"hoverlabel\": {\n        \"bgcolor\": \"lightgray\"\n      },\n      \"showlegend\": showlegend,\n      \"hovermode\": \"closest\",\n      \"legend\": {\n        \"title\": {\n          \"text\": legend_title\n        },\n        \"orientation\": \"h\",\n        \"xanchor\": \"center\",\n        \"x\": 0.5,\n        \"y\": legend_position\n      }\n    },\n    \"config\": {\n      \"showSendToCloud\": false,\n      \"displayModeBar\": false\n    }\n  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diff --git a/favicon-16x16.png b/favicon-16x16.png
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diff --git a/pkgdown.yml b/pkgdown.yml
index ddd771e..9062d1d 100644
--- a/pkgdown.yml
+++ b/pkgdown.yml
@@ -7,7 +7,7 @@ articles:
   forestly-cran: forestly-cran.html
   forestly: forestly.html
   layout: layout.html
-last_built: 2024-05-15T03:17Z
+last_built: 2024-05-20T01:58Z
 urls:
   reference: https://merck.github.io/forestly/reference
   article: https://merck.github.io/forestly/articles
diff --git a/reference/ae_forestly.html b/reference/ae_forestly.html
index b5bff1c..5752f07 100644
--- a/reference/ae_forestly.html
+++ b/reference/ae_forestly.html
@@ -63,7 +63,12 @@
 
     <div class="section level2">
     <h2 id="ref-usage">Usage<a class="anchor" aria-label="anchor" href="#ref-usage"></a></h2>
-    <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">ae_forestly</span><span class="op">(</span><span class="va">outdata</span>, filter <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"prop"</span>, <span class="st">"n"</span><span class="op">)</span>, width <span class="op">=</span> <span class="fl">1400</span><span class="op">)</span></span></code></pre></div>
+    <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">ae_forestly</span><span class="op">(</span></span>
+<span>  <span class="va">outdata</span>,</span>
+<span>  display_soc_toggle <span class="op">=</span> <span class="cn">TRUE</span>,</span>
+<span>  filter <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"prop"</span>, <span class="st">"n"</span><span class="op">)</span>,</span>
+<span>  width <span class="op">=</span> <span class="fl">1400</span></span>
+<span><span class="op">)</span></span></code></pre></div>
     </div>
 
     <div class="section level2">
@@ -72,6 +77,10 @@ <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#argumen
 <dd><p>An <code>outdata</code> object created by <code><a href="format_ae_forestly.html">format_ae_forestly()</a></code>.</p></dd>
 
 
+<dt>display_soc_toggle</dt>
+<dd><p>A boolean value to display SOC toggle button.</p></dd>
+
+
 <dt>filter</dt>
 <dd><p>A character value of the filter variable.</p></dd>
 
diff --git a/reference/format_ae_forestly.html b/reference/format_ae_forestly.html
index d54b206..510b0d7 100644
--- a/reference/format_ae_forestly.html
+++ b/reference/format_ae_forestly.html
@@ -154,30 +154,32 @@ <h2 id="ref-examples">Examples<a class="anchor" aria-label="anchor" href="#ref-e
 <span class="r-in"><span>  <span class="fu">format_ae_forestly</span><span class="op">(</span><span class="op">)</span></span></span>
 <span class="r-wrn co"><span class="r-pr">#&gt;</span> <span class="warning">Warning: </span>In observation level data, force group variable 'TRTA' be a factor</span>
 <span class="r-wrn co"><span class="r-pr">#&gt;</span> <span class="warning">Warning: </span>In observation level data, force group variable 'TRTA' be a factor</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> List of 23</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> List of 25</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>  $ meta                   :List of 7</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>  $ population             : chr "apat"</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>  $ observation            : chr "safety"</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>  $ parameter              : chr "any;rel"</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  $ n                      :'data.frame':	60 obs. of  3 variables:</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  $ order                  : num [1:60] 1008 1009 2019 2021 2022 ...</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  $ n                      :'data.frame':	79 obs. of  3 variables:</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  $ order                  : num [1:79] 1000 1008 1009 2000 2019 ...</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>  $ group                  : chr [1:3] "Placebo" "Xanomeline Low Dose" "Total"</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>  $ reference_group        : num 2</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>  $ parameter_order        : Factor w/ 2 levels "any","rel": 1 1 1 1 1 1 1 1 1 1 ...</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  $ prop                   :'data.frame':	60 obs. of  3 variables:</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  $ diff                   :'data.frame':	60 obs. of  1 variable:</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  $ prop                   :'data.frame':	79 obs. of  3 variables:</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  $ diff                   :'data.frame':	79 obs. of  1 variable:</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>  $ n_pop                  :'data.frame':	1 obs. of  3 variables:</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  $ name                   : chr [1:60] "Atrioventricular block second degree" "Bundle branch block left" "Eye allergy" "Eye pruritus" ...</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  $ ci_lower               :'data.frame':	60 obs. of  1 variable:</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  $ ci_upper               :'data.frame':	60 obs. of  1 variable:</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  $ p                      :'data.frame':	60 obs. of  1 variable:</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  $ name                   : chr [1:79] "Cardiac disorders" "Atrioventricular block second degree" "Bundle branch block left" "Eye disorders" ...</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  $ soc_name               : chr [1:79] "Cardiac disorders" "CARDIAC DISORDERS" "CARDIAC DISORDERS" "Eye disorders" ...</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  $ ci_lower               :'data.frame':	79 obs. of  1 variable:</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  $ ci_upper               :'data.frame':	79 obs. of  1 variable:</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  $ p                      :'data.frame':	79 obs. of  1 variable:</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>  $ ae_listing             :'data.frame':	151 obs. of  14 variables:</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  $ tbl                    :'data.frame':	60 obs. of  13 variables:</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  $ reactable_columns      :List of 13</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  $ tbl                    :'data.frame':	79 obs. of  14 variables:</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  $ reactable_columns      :List of 14</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>  $ reactable_columns_group:List of 3</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>  $ display                : chr [1:4] "n" "prop" "fig_prop" "fig_diff"</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>  $ fig_prop_color         : chr [1:2] "#00857C" "#66203A"</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>  $ fig_diff_color         : chr "#00857C"</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  $ hidden_column          : chr [1:6] "parameter" "diff_1" "lower_1" "upper_1" ...</span>
 </code></pre></div>
     </div>
   </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
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diff --git a/reference/prepare_ae_forestly.html b/reference/prepare_ae_forestly.html
index d239225..951b135 100644
--- a/reference/prepare_ae_forestly.html
+++ b/reference/prepare_ae_forestly.html
@@ -129,23 +129,24 @@ <h2 id="ref-examples">Examples<a class="anchor" aria-label="anchor" href="#ref-e
 <span class="r-in"><span>  <span class="fu">prepare_ae_forestly</span><span class="op">(</span><span class="op">)</span></span></span>
 <span class="r-wrn co"><span class="r-pr">#&gt;</span> <span class="warning">Warning: </span>In observation level data, force group variable 'TRTA' be a factor</span>
 <span class="r-wrn co"><span class="r-pr">#&gt;</span> <span class="warning">Warning: </span>In observation level data, force group variable 'TRTA' be a factor</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> List of 17</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> List of 18</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>  $ meta           :List of 7</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>  $ population     : chr "apat"</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>  $ observation    : chr "safety"</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>  $ parameter      : chr "any;rel"</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  $ n              :'data.frame':	60 obs. of  3 variables:</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  $ order          : num [1:60] 1008 1009 2019 2021 2022 ...</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  $ n              :'data.frame':	79 obs. of  3 variables:</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  $ order          : num [1:79] 1000 1008 1009 2000 2019 ...</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>  $ group          : chr [1:3] "Placebo" "Xanomeline Low Dose" "Total"</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>  $ reference_group: num 2</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>  $ parameter_order: Factor w/ 2 levels "any","rel": 1 1 1 1 1 1 1 1 1 1 ...</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  $ prop           :'data.frame':	60 obs. of  3 variables:</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  $ diff           :'data.frame':	60 obs. of  1 variable:</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  $ prop           :'data.frame':	79 obs. of  3 variables:</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  $ diff           :'data.frame':	79 obs. of  1 variable:</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>  $ n_pop          :'data.frame':	1 obs. of  3 variables:</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  $ name           : chr [1:60] "Atrioventricular block second degree" "Bundle branch block left" "Eye allergy" "Eye pruritus" ...</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  $ ci_lower       :'data.frame':	60 obs. of  1 variable:</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  $ ci_upper       :'data.frame':	60 obs. of  1 variable:</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  $ p              :'data.frame':	60 obs. of  1 variable:</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  $ name           : chr [1:79] "Cardiac disorders" "Atrioventricular block second degree" "Bundle branch block left" "Eye disorders" ...</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  $ soc_name       : chr [1:79] "Cardiac disorders" "CARDIAC DISORDERS" "CARDIAC DISORDERS" "Eye disorders" ...</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  $ ci_lower       :'data.frame':	79 obs. of  1 variable:</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  $ ci_upper       :'data.frame':	79 obs. of  1 variable:</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  $ p              :'data.frame':	79 obs. of  1 variable:</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>  $ ae_listing     :'data.frame':	151 obs. of  14 variables:</span>
 </code></pre></div>
     </div>
diff --git a/reference/table_panel-1.png b/reference/table_panel-1.png
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diff --git a/search.json b/search.json
index fb4d5b7..7732c7a 100644
--- a/search.json
+++ b/search.json
@@ -1 +1 @@
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Mere interaction user computer network, transfer copy, conveying. interactive user interface displays “Appropriate Legal Notices” extent includes convenient prominently visible feature (1) displays appropriate copyright notice, (2) tells user warranty work (except extent warranties provided), licensees may convey work License, view copy License. interface presents list user commands options, menu, prominent item list meets criterion.","code":""},{"path":"https://merck.github.io/forestly/LICENSE.html","id":"id_1-source-code","dir":"","previous_headings":"TERMS AND CONDITIONS","what":"1. 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License gives permission license work way, invalidate permission separately received . d) work interactive user interfaces, must display Appropriate Legal Notices; however, Program interactive interfaces display Appropriate Legal Notices, work need make . compilation covered work separate independent works, nature extensions covered work, combined form larger program, volume storage distribution medium, called “aggregate” compilation resulting copyright used limit access legal rights compilation’s users beyond individual works permit. Inclusion covered work aggregate cause License apply parts aggregate.","code":""},{"path":"https://merck.github.io/forestly/LICENSE.html","id":"id_6-conveying-non-source-forms","dir":"","previous_headings":"TERMS AND CONDITIONS","what":"6. 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Additional permissions applicable entire Program shall treated though included License, extent valid applicable law. additional permissions apply part Program, part may used separately permissions, entire Program remains governed License without regard additional permissions. convey copy covered work, may option remove additional permissions copy, part . (Additional permissions may written require removal certain cases modify work.) may place additional permissions material, added covered work, can give appropriate copyright permission. 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Termination","title":"GNU General Public License","text":"may propagate modify covered work except expressly provided License. attempt otherwise propagate modify void, automatically terminate rights License (including patent licenses granted third paragraph section 11). However, cease violation License, license particular copyright holder reinstated () provisionally, unless copyright holder explicitly finally terminates license, (b) permanently, copyright holder fails notify violation reasonable means prior 60 days cessation. Moreover, license particular copyright holder reinstated permanently copyright holder notifies violation reasonable means, first time received notice violation License (work) copyright holder, cure violation prior 30 days receipt notice. 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If not, see <http://www.gnu.org/licenses/>. <program>  Copyright (C) <year>  <name of author> This program comes with ABSOLUTELY NO WARRANTY; for details type 'show w'. This is free software, and you are welcome to redistribute it under certain conditions; type 'show c' for details."},{"path":"https://merck.github.io/forestly/articles/design-pattern.html","id":"overview","dir":"Articles","previous_headings":"","what":"Overview","title":"Design Plan of R Package forestly","text":"forestly package developed generate interactive forest plot safety analysis clinical trials. generate interactive forest plot, develop three main functions listed . details three main functions introduced next three sections separately. tidy_ae_table: function used obtain adverse event (AE) information ready visualization. download_ae_reports: function used generate download button, users can download AE summary tables clicking button. forestly: function used generate interactive forest plot. minimal example summarized major steps using forestly package ","code":"mydata <- tidy_ae_table(...)    # Step 1: create tidy AE data download_ae_reports(mydata)     # Step 2: generate download button forestly(mydata)                # Step 3: generate interactive forest plot                                 # (the order of Step 2 and Step 3 can be reversed)"},{"path":"https://merck.github.io/forestly/articles/design-pattern.html","id":"main-function-1-tidy_ae_table","dir":"Articles","previous_headings":"","what":"Main function 1: tidy_ae_table()","title":"Design Plan of R Package forestly","text":"main function tidy_ae_table() used obtain AE information ready visualization. Specifically speaking, merges standardized adsl adae tables together, outputs AE summary table. AE summary table summarizes number/ratio subjects experiencing certain AE treatment arm control arm. utility functions developed inside tidy_ae_table() list follows. tidy_population(): function used prepare observation datasets use function tidy_ae_table(). function filter adsl dataset, define proper treatment order dataset. tidy_observation(): function used prepare observation datasets use function tidy_ae_table(). function filter adae dataset, define proper treatment order dataset. `prop_test_mn(): function tests equal proportion using Miettinen Nurminen method. forestly package, generates confidence interval (CI) risk difference treatment arm control arm. define_ae_selectList(): function specify AE labels displayed select list interactive forestly plot. two arguments, (1) ae_criterion (2) ae_label. first argument ae_criterion (vector ) string, defines criterion select class AE display interactive forest plot. example, ae_criterion = 'AESER == \"Y\"', select serious AE. second argument ae_label (vector ) string, defines labels displayed select list interactive forest plot. two arguments string vectors, must 1:1 map. function used arguments ae_interested = function tidy_ae_table() (see examples ). throws errors length ae_criterion doesn’t match ae_label. tidy_multi_ae_label(): function design rbind data together according interested AE labels defined ae_interested =. example, use Example 1 , tidy_multi_ae_label() generate AE summary table rbind(summary table AE, summary serious AE). tidy_ae_listing(): function generates data frame serves listed details reactable.","code":"# Example 1: if you would like to display the serious AE tidy_ae_table(...,               ae_interested = define_ae_selectList(ae_criterion = 'AESER == \"Y\"',                                                    ae_label = \"serious AE\"),               ...).  # Example 2: if you would like to display both serious AE and drug-related AE tidy_ae_table(...,               ae_interested = define_ae_selectList(ae_criterion = c('AESER != \"N\"', 'AEREL != \"None\"'),                                                    ae_label = c(\"serious AE\", \"drug-related AE\")               ...)."},{"path":"https://merck.github.io/forestly/articles/design-pattern.html","id":"main-function-2-tlf_download","dir":"Articles","previous_headings":"","what":"Main function 2: tlf_download()","title":"Design Plan of R Package forestly","text":"function generates download button users download AE tables. Example: https://merck.github.io/r2rtf/articles/example-ae-summary.html tlf_ae_specific: function create specific AE table. tlf_ae_listing: function create AE listing. output tlf_xxx functions r2rtf objects created rtf_encode tlf_download: function download multiple TLFs Rmarkdown. Rewrite ae_download_report allow use tlf_xxx functions input.","code":"tlf_ae_summary()   # generate the AE summary table tlf_ae_specific()  # generate the specific AE table # tlf[[4]] <- tlf_ae_listing()   # As needed ????  tlf_download()    # download the above tables"},{"path":"https://merck.github.io/forestly/articles/design-pattern.html","id":"main-function-3-forestly","dir":"Articles","previous_headings":"","what":"Main function 3: forestly()","title":"Design Plan of R Package forestly","text":"function generates interactive forest plot returned objected tidy_ae_table(). interactive forstly plot, consists two blocks. first block select list. items listed select list specified ae_label = function tidy_ae_table(..., ae_interested = , ...). clicking different AE labels, different reactable generated. example, click “serious AE”, reactable display serious AE summary table. main tool develop block crosstalk::filter_select(). second block reactable. reactable summarizes AE information selected AE label. main tool develop block reactable::reactable(). utility functions used develop forestly() listed follows. forestly_design_details(): function returns design details reactable forest plot, including design details cell two proportions; design details cell CI; design details footer two proportions; design details footer CI. design details returned another utility function sparkline_point_js(), introduce details later. generate design details, users need specify elements design, including color: color two proportion/CI plot (see arguments fig_prop_color = fig_diff_color =); label: labels displayed two proportion/CI plot (see arguments fig_prop_label = fig_diff_label =); column width: column width two proportion/CI plot (see arguments fig_prop_colwidth = fig_diff_colwidth =); range: x-axis range plot two proportion/CI plot (see arguments fig_prop_range = fig_diff_range =). sparkline_point_js(): function generates Javascript rendered. used design details reactables, including cell footer. dependence files path forestly/inst/js/sparkline.js. mk_reactable(): function used create data table tabular data sorting pagination default. Essentially, wrapper function reactable() robust BAAMR usage. dependence R package reactable.","code":""},{"path":"https://merck.github.io/forestly/articles/design-pattern.html","id":"other-utility-filesfunctions","dir":"Articles","previous_headings":"","what":"Other utility files/functions","title":"Design Plan of R Package forestly","text":"important_functions.R: used declare R-package dependency functions used develop functions.","code":""},{"path":"https://merck.github.io/forestly/articles/forestly.html","id":"overview","dir":"Articles","previous_headings":"","what":"Overview","title":"Interactive Forest Plot","text":"forestly package creates interactive forest plots clinical trial analysis & reporting. Specific adverse events analysis Subgroup analysis assume ADaM datasets ready analysis leverage metalite data structure define inputs outputs.","code":"forestly_adsl$TRTA <- factor(forestly_adsl$TRT01A, levels = c(\"Xanomeline Low Dose\", \"Placebo\"), labels = c(\"Low Dose\", \"Placebo\"))  forestly_adae$TRTA <- factor(forestly_adae$TRTA, levels = c(\"Xanomeline Low Dose\", \"Placebo\"), labels = c(\"Low Dose\", \"Placebo\")) meta_forestly(   dataset_adsl = forestly_adsl,   dataset_adae = forestly_adae,   parameter_term = \"any;rel;ser\" ) |>   prepare_ae_forestly() |>   format_ae_forestly() |>   ae_forestly()"},{"path":"https://merck.github.io/forestly/articles/forestly.html","id":"interactive-features","dir":"Articles","previous_headings":"","what":"Interactive features","title":"Interactive Forest Plot","text":"interactive features example include: Select different AE criteria. Filter incidence AE one group. Revealed information hovering mouse point. Search bars find subjects selected adverse events (AE). Sort value click column header. Drill-listing clicking \\(\\blacktriangleright\\).","code":""},{"path":"https://merck.github.io/forestly/articles/forestly.html","id":"workflow","dir":"Articles","previous_headings":"","what":"Workflow","title":"Interactive Forest Plot","text":"general workflow : meta_forestly() constructs input metadata treatment analysis ADaM datasets. prepare_ae_forestly() prepares datasets interactive forest plot. format_ae_forestly() formats output layout. ae_forestly() generates interactive forest plot. meta_forestly() wrapper function metalite package. function users simplify process define input parameters required generate interactive forest plot. meta_forestly function require dataset_adsl, dataset_adae, observation_term population_term arguments. dataset_adsl, dataset_adae input ADaM dataset population observation. example, use “apat” population_term “wk12” observation_term. subset creteria terms, using SAFFL == \"Y\" default meta_forestly(). user wants customize definitions terms define new terms, tutorials can found link. paramter level metadata, parameter_term selected predefined terms listed . default, choose three parameter terms rel, ser use “;” concatenate allow three types AE displayed one interactive forest plot. following example, define ITT subset criteria ITTFL == \"Y\"population TEAE subset criteria TRTEMFL == \"Y\" observation. parameter, choose ser nonser pre-defined parameter list. metadata defined, can create interactive forest plot . section, calculate statistics prepare plotting dataset using prepare_ae_forestly(). Argument parameter required since can select parameter one defined metadata. use format_ae_forestly() format output ae_forestly() create interactive forest plot. Default value used arguments two functions. first example, select , ser nonser. example select , rel ser.","code":"meta_forestly(   dataset_adsl = forestly_adsl,   dataset_adae = forestly_adae,   parameter_term = \"any;rel;ser\" ) #> ADaM metadata:  #>    .$data_population     Population data with 170 subjects  #>    .$data_observation    Observation data with 736 records  #>    .$plan    Analysis plan with 1 plans  #>  #>  #>   Analysis population type: #>     name        id  group var       subset label #> 1 'apat' 'USUBJID' 'TRTA'     SAFFL == 'Y'    '' #>  #>  #>   Analysis observation type: #>       name        id  group var       subset label #> 1 'safety' 'USUBJID' 'TRTA'     SAFFL == 'Y'    '' #>  #>  #>   Analysis parameter type: #>    name                         label                     subset #> 1 'any'          'any adverse events'                            #> 2 'rel' 'drug-related adverse events' toupper(AREL) == 'RELATED' #> 3 'ser'      'serious adverse events'               AESER == 'Y' #>  #>  #>   Analysis function: #>            name                     label #> 1 'ae_forestly' 'Interactive forest plot' meta <- meta_forestly(   dataset_adsl = forestly_adsl,   dataset_adae = forestly_adae,   population_term = \"ITT\",   population_subset = ITTFL == \"Y\",   observation_term = \"TEAE\",   observation_subset = TRTEMFL == \"Y\",   parameter_term = \"any;ser;nonser;rel\" ) meta #> ADaM metadata:  #>    .$data_population     Population data with 170 subjects  #>    .$data_observation    Observation data with 736 records  #>    .$plan    Analysis plan with 1 plans  #>  #>  #>   Analysis population type: #>    name        id  group var       subset label #> 1 'ITT' 'USUBJID' 'TRTA'     ITTFL == 'Y'    '' #>  #>  #>   Analysis observation type: #>     name        id  group var         subset label #> 1 'TEAE' 'USUBJID' 'TRTA'     TRTEMFL == 'Y'    '' #>  #>  #>   Analysis parameter type: #>       name                         label                      subset #> 1    'any'          'any adverse events'                             #> 2    'ser'      'serious adverse events'                AESER == 'Y' #> 3 'nonser'  'non-serious adverse events' AESER != 'Y' | is.na(AESER) #> 4    'rel' 'drug-related adverse events'  toupper(AREL) == 'RELATED' #>  #>  #>   Analysis function: #>            name                     label #> 1 'ae_forestly' 'Interactive forest plot' meta |>   prepare_ae_forestly(parameter = \"any;ser;nonser\") |>   format_ae_forestly() |>   ae_forestly() meta |>   prepare_ae_forestly(parameter = \"any;rel;ser\") |>   format_ae_forestly() |>   ae_forestly()"},{"path":"https://merck.github.io/forestly/articles/forestly.html","id":"define-metadata","dir":"Articles","previous_headings":"","what":"Define metadata","title":"Interactive Forest Plot","text":"order provide flexibility different analysis, forestly package also allows way construct metadata. show simplified example metalite package. details can found metalite package website. start construct metadata using metalite. output metadata contains two observation wk12 period1 illustration purpose. Also, parameter, subset criteria AEREL %% c(\"POSSIBLE\", \"PROBABLE\") instead toupper(AREL) == \"RELATED\" order fit observation dataset. metadata defined, can create interactive forest plot wk12 . Using similar approach, create interactive forest plot period1.","code":"library(metalite) meta <- meta_adam(   population = forestly_adsl,   observation = forestly_adae ) |>   define_plan(plan = plan(     analysis = \"ae_forestly\",     population = \"apat\",     observation = c(\"wk12\", \"period1\"),     parameter = \"any;rel;ser\"   )) |>   define_population(     name = \"apat\",     group = \"TRTA\",     subset = quote(SAFFL == \"Y\")   ) |>   define_observation(     name = \"wk12\",     group = \"TRTA\",     subset = quote(SAFFL == \"Y\"),     label = \"Weeks 0 to 12\"   ) |>   define_observation(     name = \"period1\",     group = \"TRTA\",     var = \"AEDECOD\",     subset = quote(TRTEMFL == \"Y\" & SAFFL == \"Y\"),     label = \"Period 1\"   ) |>   define_parameter(     name = \"rel\",     subset = quote(AEREL %in% c(\"POSSIBLE\", \"PROBABLE\"))   ) |>   define_analysis(     name = \"ae_forestly\",     label = \"Interactive forest plot\"   ) |>   meta_build() meta #> ADaM metadata:  #>    .$data_population     Population data with 170 subjects  #>    .$data_observation    Observation data with 736 records  #>    .$plan    Analysis plan with 2 plans  #>  #>  #>   Analysis population type: #>     name        id  group var       subset                         label #> 1 'apat' 'USUBJID' 'TRTA'     SAFFL == 'Y' 'All Participants as Treated' #>  #>  #>   Analysis observation type: #>        name        id  group       var                        subset #> 1    'wk12' 'USUBJID' 'TRTA'                            SAFFL == 'Y' #> 2 'period1' 'USUBJID' 'TRTA' 'AEDECOD' TRTEMFL == 'Y' & SAFFL == 'Y' #>             label #> 1 'Weeks 0 to 12' #> 2      'Period 1' #>  #>  #>   Analysis parameter type: #>    name                         label                               subset #> 1 'rel' 'drug-related adverse events' AEREL %in% c('POSSIBLE', 'PROBABLE') #> 2 'any'          'any adverse events'                                      #> 3 'ser'      'serious adverse events'                         AESER == 'Y' #>  #>  #>   Analysis function: #>            name                     label #> 1 'ae_forestly' 'Interactive forest plot' meta |>   prepare_ae_forestly(     population = \"apat\",     observation = \"wk12\",     parameter = \"any;rel;ser\"   ) |>   format_ae_forestly() |>   ae_forestly() meta |>   prepare_ae_forestly(     population = \"apat\",     observation = \"period1\",     parameter = \"any;rel;ser\"   ) |>   format_ae_forestly() |>   ae_forestly()"},{"path":"https://merck.github.io/forestly/articles/layout.html","id":"overview","dir":"Articles","previous_headings":"","what":"Overview","title":"Controlling Layout","text":"forestly package controls forest plot layouts simple effective approach. illustrate idea, use ADSL (forestly_adsl_3grp) ADAE (forestly_adae_3grp) datasets forestly package contain three treatment groups. first step create required metadata using meta_forestly(). use prepare_ae_forestly() prepare input datasets interactive forest plot. outdata contains parameters required generate interactive forest plot. interactive forest plot default style can generated.","code":"metadata <- meta_forestly(   dataset_adsl = forestly_adsl_3grp,   dataset_adae = forestly_adae_3grp,   parameter_term = \"any;rel;ser\" )  outdata <- metadata |> prepare_ae_forestly()  outdata #> List of 17 #>  $ meta           :List of 7 #>  $ population     : chr \"apat\" #>  $ observation    : chr \"safety\" #>  $ parameter      : chr \"any;rel;ser\" #>  $ n              :'data.frame': 361 obs. of  4 variables: #>  $ order          : num [1:361] 1030 1031 1032 1033 1034 ... #>  $ group          : chr [1:4] \"Placebo\" \"Low Dose\" \"High Dose\" \"Total\" #>  $ reference_group: num 1 #>  $ parameter_order: Factor w/ 3 levels \"any\",\"rel\",\"ser\": 1 1 1 1 1 1 1 1 1 1 ... #>  $ prop           :'data.frame': 361 obs. of  4 variables: #>  $ diff           :'data.frame': 361 obs. of  2 variables: #>  $ n_pop          :'data.frame': 1 obs. of  4 variables: #>  $ name           : chr [1:361] \"Atrial fibrillation\" \"Atrial flutter\" \"Atrial hypertrophy\" \"Atrioventricular block first degree\" ... #>  $ ci_lower       :'data.frame': 361 obs. of  2 variables: #>  $ ci_upper       :'data.frame': 361 obs. of  2 variables: #>  $ p              :'data.frame': 361 obs. of  2 variables: #>  $ ae_listing     :'data.frame': 1898 obs. of  14 variables: outdata |>   format_ae_forestly() |>   ae_forestly()"},{"path":"https://merck.github.io/forestly/articles/layout.html","id":"change-color","dir":"Articles","previous_headings":"","what":"Change color","title":"Controlling Layout","text":"default, forestly using teal treatment group plum control group. user wants change color, color argument format_ae_forestly() function can used. example interactive forest plot using black grey.","code":"outdata |>   format_ae_forestly(color = c(\"black\", \"grey60\", \"grey40\")) |>   ae_forestly()"},{"path":"https://merck.github.io/forestly/articles/layout.html","id":"display-different-columns","dir":"Articles","previous_headings":"","what":"Display different columns","title":"Controlling Layout","text":"using display argument format_ae_forestly(), can display total column. can also display risk difference columns similar approach.","code":"outdata |>   format_ae_forestly(display = c(\"n\", \"prop\", \"fig_prop\", \"fig_diff\", \"total\")) |>   ae_forestly() outdata |>   format_ae_forestly(display = c(\"n\", \"prop\", \"fig_prop\", \"fig_diff\", \"diff\")) |>   ae_forestly()"},{"path":"https://merck.github.io/forestly/articles/layout.html","id":"control-column-width","dir":"Articles","previous_headings":"","what":"Control column width","title":"Controlling Layout","text":"can control column width customize layout.","code":"outdata |>   format_ae_forestly(     width_fig = 230,     footer_space = 110   ) |>   ae_forestly(width = 1000)"},{"path":"https://merck.github.io/forestly/articles/layout.html","id":"horizontal-scrolling","dir":"Articles","previous_headings":"","what":"Horizontal scrolling","title":"Controlling Layout","text":"Set ae_forestly(..., width = NULL) make element scrollable horizontally. particularly useful embedding plot pages responsive design, using frameworks Bootstrap.","code":""},{"path":"https://merck.github.io/forestly/articles/layout.html","id":"change-variable-listed-in-drill-down-table","dir":"Articles","previous_headings":"","what":"Change variable listed in drill-down table","title":"Controlling Layout","text":"Users can explore AE listing clicking \\(\\blacktriangleright\\) row specify column names ae_listing_display.","code":"listing_var <- c(   \"SEX\", \"RACE\", \"AGE\",   \"SITEID\", \"AESEV\", \"STUDYID\",   \"AESER\", \"AEREL\", \"ASTDT\", \"AENDT\" )  metadata |>   prepare_ae_forestly(     ae_listing_display = listing_var   ) |>   format_ae_forestly() |>   ae_forestly()"},{"path":"https://merck.github.io/forestly/articles/layout.html","id":"hide-filters","dir":"Articles","previous_headings":"","what":"Hide filters","title":"Controlling Layout","text":"can use simple CSS rules hide incidence rate filter element. example, R Markdown document, use:","code":"```{css, echo=FALSE} #filter_subject {   display: none; } ```"},{"path":"https://merck.github.io/forestly/authors.html","id":null,"dir":"","previous_headings":"","what":"Authors","title":"Authors and Citation","text":"Yilong Zhang. Author. Benjamin Wang. Author, maintainer. Yujie Zhao. Author. Nan Xiao. Contributor. Hiroaki Fukuda. Contributor. Yulia Sidi. Contributor. Xuan Deng. Contributor. Merck & Co., Inc., Rahway, NJ, USA affiliates. Copyright holder.","code":""},{"path":"https://merck.github.io/forestly/authors.html","id":"citation","dir":"","previous_headings":"","what":"Citation","title":"Authors and Citation","text":"Zhang Y, Wang B, Zhao Y (2024). forestly: Interactive Forest Plot. R package version 0.1.1, https://github.com/Merck/forestly, https://merck.github.io/forestly/.","code":"@Manual{,   title = {forestly: Interactive Forest Plot},   author = {Yilong Zhang and Benjamin Wang and Yujie Zhao},   year = {2024},   note = {R package version 0.1.1, https://github.com/Merck/forestly},   url = {https://merck.github.io/forestly/}, }"},{"path":[]},{"path":"https://merck.github.io/forestly/index.html","id":"installation","dir":"","previous_headings":"","what":"Installation","title":"Interactive Forest Plot","text":"easiest way get forestly install CRAN: Alternatively, use new feature get bug fix, can install development version forestly GitHub:","code":"install.packages(\"forestly\") # install.packages(\"remotes\") remotes::install_github(\"Merck/forestly\")"},{"path":"https://merck.github.io/forestly/index.html","id":"overview","dir":"","previous_headings":"","what":"Overview","title":"Interactive Forest Plot","text":"forestly package creates interactive forest plots clinical trial analysis & reporting. Specific adverse events analysis Subgroup analysis assume ADaM datasets ready analysis leverage metalite data structure define inputs outputs.","code":""},{"path":"https://merck.github.io/forestly/index.html","id":"workflow","dir":"","previous_headings":"","what":"Workflow","title":"Interactive Forest Plot","text":"general workflow : meta_forestly() constructs input metadata treatment analysis ADaM datasets. prepare_ae_forestly() prepares datasets interactive forest plot. format_ae_forestly() formats output layout. ae_forestly() generates interactive forest plot. quick example","code":"library(\"forestly\")  meta_forestly(   forestly_adsl,   forestly_adae ) |>   prepare_ae_forestly(parameter = \"any;rel;ser\") |>   format_ae_forestly() |>   ae_forestly()"},{"path":"https://merck.github.io/forestly/index.html","id":"interactive-features","dir":"","previous_headings":"","what":"Interactive features","title":"Interactive Forest Plot","text":"interactive features safety analysis include: Select different AE criteria. Filter incidence AE one groups. Reveal information hovering mouse data point. Search bars find subjects selected adverse events (AEs). Sort value clicking column header. Drill-listing clicking ▸.","code":""},{"path":"https://merck.github.io/forestly/index.html","id":"references","dir":"","previous_headings":"","what":"References","title":"Interactive Forest Plot","text":"Paper: 2023 PHUSE US Connect Talk: 2021 R/Pharma Conference","code":""},{"path":"https://merck.github.io/forestly/reference/ae_forestly.html","id":null,"dir":"Reference","previous_headings":"","what":"Display interactive forest plot — ae_forestly","title":"Display interactive forest plot — ae_forestly","text":"Display interactive forest plot","code":""},{"path":"https://merck.github.io/forestly/reference/ae_forestly.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Display interactive forest plot — ae_forestly","text":"","code":"ae_forestly(outdata, filter = c(\"prop\", \"n\"), width = 1400)"},{"path":"https://merck.github.io/forestly/reference/ae_forestly.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Display interactive forest plot — ae_forestly","text":"outdata outdata object created format_ae_forestly(). filter character value filter variable. width numeric value width table pixels.","code":""},{"path":"https://merck.github.io/forestly/reference/ae_forestly.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Display interactive forest plot — ae_forestly","text":"AE forest plot saved shiny.tag.list object.","code":""},{"path":"https://merck.github.io/forestly/reference/ae_forestly.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Display interactive forest plot — ae_forestly","text":"","code":"adsl <- forestly_adsl[1:100, ] adae <- forestly_adae[1:100, ] if (interactive()) {   meta_forestly(     dataset_adsl = adsl,     dataset_adae = adae,   ) |>     prepare_ae_forestly() |>     format_ae_forestly() |>     ae_forestly() }"},{"path":"https://merck.github.io/forestly/reference/background_panel.html","id":null,"dir":"Reference","previous_headings":"","what":"Add background for creating plot with customized color — background_panel","title":"Add background for creating plot with customized color — background_panel","text":"Creates colored background panels rainfall forest plot.","code":""},{"path":"https://merck.github.io/forestly/reference/background_panel.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Add background for creating plot with customized color — background_panel","text":"","code":"background_panel(   g,   background_color = c(\"#69B8F7\", \"#FFFFFF\"),   background_alpha = 0.3 )"},{"path":"https://merck.github.io/forestly/reference/background_panel.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Add background for creating plot with customized color — background_panel","text":"g ggplot object adding colored background. background_color vector colors defines color plot background. Default c(\"#69B8F7\", \"#FFFFFF\"), pastel blue white. colors recycled. background_alpha Opacity geom. Default 0.3.","code":""},{"path":"https://merck.github.io/forestly/reference/background_panel.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Add background for creating plot with customized color — background_panel","text":"Plot colored background add panels rainfall forest plot.","code":""},{"path":"https://merck.github.io/forestly/reference/background_panel.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Add background for creating plot with customized color — background_panel","text":"","code":"library(ggplot2)  df <- data.frame(   study = c(\"S1\", \"S2\", \"S3\", \"S4\", \"S5\", \"S6\", \"S7\"),   item = as.factor(1:7),   effect = c(-.4, -.25, -.1, .1, .15, .2, .3),   lower = c(-.43, -.29, -.17, -.02, .04, .17, .27),   upper = c(-.37, -.21, -.03, .22, .24, .23, .33) )  ggplot(data = df) |>   background_panel(background_color = c(\"grey\", \"white\"), background_alpha = 0.4) +   geom_point(aes(y = item, x = effect)) +   geom_errorbar(aes(y = item, x = effect, xmin = lower, xmax = upper), width = 0.4) +   scale_y_discrete(name = \"\", breaks = 1:nrow(df), labels = df$study)"},{"path":"https://merck.github.io/forestly/reference/forestly_adae.html","id":null,"dir":"Reference","previous_headings":"","what":"An adverse event dataset — forestly_adae","title":"An adverse event dataset — forestly_adae","text":"dataset containing adverse event information clinical trial following CDISC ADaM standard.","code":""},{"path":"https://merck.github.io/forestly/reference/forestly_adae.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"An adverse event dataset — forestly_adae","text":"","code":"forestly_adae"},{"path":"https://merck.github.io/forestly/reference/forestly_adae.html","id":"format","dir":"Reference","previous_headings":"","what":"Format","title":"An adverse event dataset — forestly_adae","text":"data frame 736 rows 56 variables.","code":""},{"path":"https://merck.github.io/forestly/reference/forestly_adae.html","id":"source","dir":"Reference","previous_headings":"","what":"Source","title":"An adverse event dataset — forestly_adae","text":"https://github.com/phuse-org/phuse-scripts/tree/master/data/adam/cdisc","code":""},{"path":"https://merck.github.io/forestly/reference/forestly_adae.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"An adverse event dataset — forestly_adae","text":"Definition variable can found https://github.com/phuse-org/phuse-scripts/tree/master/data/adam/cdisc.","code":""},{"path":"https://merck.github.io/forestly/reference/forestly_adae_3grp.html","id":null,"dir":"Reference","previous_headings":"","what":"An adverse event dataset — forestly_adae_3grp","title":"An adverse event dataset — forestly_adae_3grp","text":"dataset containing adverse event information clinical trial following CDISC ADaM standard.","code":""},{"path":"https://merck.github.io/forestly/reference/forestly_adae_3grp.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"An adverse event dataset — forestly_adae_3grp","text":"","code":"forestly_adae_3grp"},{"path":"https://merck.github.io/forestly/reference/forestly_adae_3grp.html","id":"format","dir":"Reference","previous_headings":"","what":"Format","title":"An adverse event dataset — forestly_adae_3grp","text":"data frame 1191 rows 56 variables.","code":""},{"path":"https://merck.github.io/forestly/reference/forestly_adae_3grp.html","id":"source","dir":"Reference","previous_headings":"","what":"Source","title":"An adverse event dataset — forestly_adae_3grp","text":"https://github.com/phuse-org/phuse-scripts/tree/master/data/adam/cdisc","code":""},{"path":"https://merck.github.io/forestly/reference/forestly_adae_3grp.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"An adverse event dataset — forestly_adae_3grp","text":"Definition variable can found https://github.com/phuse-org/phuse-scripts/tree/master/data/adam/cdisc.","code":""},{"path":"https://merck.github.io/forestly/reference/forestly_adsl.html","id":null,"dir":"Reference","previous_headings":"","what":"A subject level demographic dataset — forestly_adsl","title":"A subject level demographic dataset — forestly_adsl","text":"dataset containing demographic information clinical trial following CDISC ADaM standard.","code":""},{"path":"https://merck.github.io/forestly/reference/forestly_adsl.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"A subject level demographic dataset — forestly_adsl","text":"","code":"forestly_adsl"},{"path":"https://merck.github.io/forestly/reference/forestly_adsl.html","id":"format","dir":"Reference","previous_headings":"","what":"Format","title":"A subject level demographic dataset — forestly_adsl","text":"data frame 170 rows 49 variables.","code":""},{"path":"https://merck.github.io/forestly/reference/forestly_adsl.html","id":"source","dir":"Reference","previous_headings":"","what":"Source","title":"A subject level demographic dataset — forestly_adsl","text":"https://github.com/phuse-org/phuse-scripts/tree/master/data/adam/cdisc","code":""},{"path":"https://merck.github.io/forestly/reference/forestly_adsl.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"A subject level demographic dataset — forestly_adsl","text":"Definition variable can found https://github.com/phuse-org/phuse-scripts/tree/master/data/adam/cdisc.","code":""},{"path":"https://merck.github.io/forestly/reference/forestly_adsl_3grp.html","id":null,"dir":"Reference","previous_headings":"","what":"A subject level demographic dataset — forestly_adsl_3grp","title":"A subject level demographic dataset — forestly_adsl_3grp","text":"dataset containing demographic information clinical trial following CDISC ADaM standard.","code":""},{"path":"https://merck.github.io/forestly/reference/forestly_adsl_3grp.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"A subject level demographic dataset — forestly_adsl_3grp","text":"","code":"forestly_adsl_3grp"},{"path":"https://merck.github.io/forestly/reference/forestly_adsl_3grp.html","id":"format","dir":"Reference","previous_headings":"","what":"Format","title":"A subject level demographic dataset — forestly_adsl_3grp","text":"data frame 254 rows 49 variables.","code":""},{"path":"https://merck.github.io/forestly/reference/forestly_adsl_3grp.html","id":"source","dir":"Reference","previous_headings":"","what":"Source","title":"A subject level demographic dataset — forestly_adsl_3grp","text":"https://github.com/phuse-org/phuse-scripts/tree/master/data/adam/cdisc","code":""},{"path":"https://merck.github.io/forestly/reference/forestly_adsl_3grp.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"A subject level demographic dataset — forestly_adsl_3grp","text":"Definition variable can found https://github.com/phuse-org/phuse-scripts/tree/master/data/adam/cdisc.","code":""},{"path":"https://merck.github.io/forestly/reference/format_ae_forestly.html","id":null,"dir":"Reference","previous_headings":"","what":"Format outdata for interactive forest plot — format_ae_forestly","title":"Format outdata for interactive forest plot — format_ae_forestly","text":"Format outdata interactive forest plot","code":""},{"path":"https://merck.github.io/forestly/reference/format_ae_forestly.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Format outdata for interactive forest plot — format_ae_forestly","text":"","code":"format_ae_forestly(   outdata,   display = c(\"n\", \"prop\", \"fig_prop\", \"fig_diff\"),   digits = 1,   width_term = 200,   width_fig = 320,   width_n = 40,   width_prop = 60,   width_diff = 80,   footer_space = 90,   color = NULL,   diff_label = \"Treatment <- Favor -> Placebo\",   show_ae_parameter = FALSE )"},{"path":"https://merck.github.io/forestly/reference/format_ae_forestly.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Format outdata for interactive forest plot — format_ae_forestly","text":"outdata outdata object created prepare_ae_forestly(). display character vector measurement displayed. n: Number subjects AE. prop: Proportion subjects AE. total: Total columns. diff: Risk difference. digits value digits displayed proportion risk difference. width_term Width px AE term column. width_fig Width px proportion risk difference figure. width_n Width px \"N\" columns. width_prop Width px \"(%)\" columns. width_diff Width px risk difference columns. footer_space Space px footer display legend. color vector colors analysis groups. Default value supports 4 groups. diff_label x-axis label risk difference. show_ae_parameter boolean value display AE parameter column.","code":""},{"path":"https://merck.github.io/forestly/reference/format_ae_forestly.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Format outdata for interactive forest plot — format_ae_forestly","text":"outdata object.","code":""},{"path":"https://merck.github.io/forestly/reference/format_ae_forestly.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Format outdata for interactive forest plot — format_ae_forestly","text":"","code":"adsl <- forestly_adsl[1:100,] adae <- forestly_adae[1:100,] meta_forestly(   dataset_adsl = adsl,   dataset_adae = adae ) |>   prepare_ae_forestly()|>   format_ae_forestly() #> Warning: In observation level data, force group variable 'TRTA' be a factor #> Warning: In observation level data, force group variable 'TRTA' be a factor #> List of 23 #>  $ meta                   :List of 7 #>  $ population             : chr \"apat\" #>  $ observation            : chr \"safety\" #>  $ parameter              : chr \"any;rel\" #>  $ n                      :'data.frame':\t60 obs. of  3 variables: #>  $ order                  : num [1:60] 1008 1009 2019 2021 2022 ... #>  $ group                  : chr [1:3] \"Placebo\" \"Xanomeline Low Dose\" \"Total\" #>  $ reference_group        : num 2 #>  $ parameter_order        : Factor w/ 2 levels \"any\",\"rel\": 1 1 1 1 1 1 1 1 1 1 ... #>  $ prop                   :'data.frame':\t60 obs. of  3 variables: #>  $ diff                   :'data.frame':\t60 obs. of  1 variable: #>  $ n_pop                  :'data.frame':\t1 obs. of  3 variables: #>  $ name                   : chr [1:60] \"Atrioventricular block second degree\" \"Bundle branch block left\" \"Eye allergy\" \"Eye pruritus\" ... #>  $ ci_lower               :'data.frame':\t60 obs. of  1 variable: #>  $ ci_upper               :'data.frame':\t60 obs. of  1 variable: #>  $ p                      :'data.frame':\t60 obs. of  1 variable: #>  $ ae_listing             :'data.frame':\t151 obs. of  14 variables: #>  $ tbl                    :'data.frame':\t60 obs. of  13 variables: #>  $ reactable_columns      :List of 13 #>  $ reactable_columns_group:List of 3 #>  $ display                : chr [1:4] \"n\" \"prop\" \"fig_prop\" \"fig_diff\" #>  $ fig_prop_color         : chr [1:2] \"#00857C\" \"#66203A\" #>  $ fig_diff_color         : chr \"#00857C\""},{"path":"https://merck.github.io/forestly/reference/meta_forestly.html","id":null,"dir":"Reference","previous_headings":"","what":"Create metadata for interactive forest plot — meta_forestly","title":"Create metadata for interactive forest plot — meta_forestly","text":"Create metadata interactive forest plot","code":""},{"path":"https://merck.github.io/forestly/reference/meta_forestly.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Create metadata for interactive forest plot — meta_forestly","text":"","code":"meta_forestly(   dataset_adsl,   dataset_adae,   population_term = \"apat\",   observation_term = \"safety\",   parameter_term = \"any;rel\",   population_subset = SAFFL == \"Y\",   observation_subset = SAFFL == \"Y\",   treatment_group = \"TRTA\" )"},{"path":"https://merck.github.io/forestly/reference/meta_forestly.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Create metadata for interactive forest plot — meta_forestly","text":"dataset_adsl ADSL source dataset. dataset_adae ADAE source dataset. population_term character value population term name. observation_term character value observation term name. parameter_term character value parameter term name. population_subset unquoted condition selecting populations ADSL dataset. observation_subset unquoted condition selecting observations ADAE dataset. treatment_group character value treatment group name.","code":""},{"path":"https://merck.github.io/forestly/reference/meta_forestly.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Create metadata for interactive forest plot — meta_forestly","text":"metalite object.","code":""},{"path":"https://merck.github.io/forestly/reference/meta_forestly.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Create metadata for interactive forest plot — meta_forestly","text":"","code":"meta_forestly(   forestly_adsl,   forestly_adae,   population_term = \"apat\",   observation_term = \"safety\",   parameter_term = \"any;rel\" ) #> ADaM metadata:  #>    .$data_population \tPopulation data with 170 subjects  #>    .$data_observation \tObservation data with 736 records  #>    .$plan \tAnalysis plan with 1 plans  #>  #>  #>   Analysis population type: #>     name        id  group var       subset label #> 1 'apat' 'USUBJID' 'TRTA'     SAFFL == 'Y'    '' #>  #>  #>   Analysis observation type: #>       name        id  group var       subset label #> 1 'safety' 'USUBJID' 'TRTA'     SAFFL == 'Y'    '' #>  #>  #>   Analysis parameter type: #>    name                         label                     subset #> 1 'any'          'any adverse events'                            #> 2 'rel' 'drug-related adverse events' toupper(AREL) == 'RELATED' #>  #>  #>   Analysis function: #>            name                     label #> 1 'ae_forestly' 'Interactive forest plot' #>"},{"path":"https://merck.github.io/forestly/reference/plot_dot.html","id":null,"dir":"Reference","previous_headings":"","what":"Dot plot — plot_dot","title":"Dot plot — plot_dot","text":"Create dot plot item. instance, used create AEs incidence plot Preferred Term treatment group, part rainfall plot.","code":""},{"path":"https://merck.github.io/forestly/reference/plot_dot.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Dot plot — plot_dot","text":"","code":"plot_dot(   tbl,   y_var,   label,   x_breaks = NULL,   color = NULL,   shape = NULL,   title = \"AE (%)\",   background_color = c(\"#69B8F7\", \"#FFFFFF\"),   background_alpha = 0.3,   theme = theme_panel(show_text = TRUE, show_ticks = TRUE),   legend_nrow = 1 )"},{"path":"https://merck.github.io/forestly/reference/plot_dot.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Dot plot — plot_dot","text":"tbl data frame selected input data set display plot. y x variables required. y_var character string specifies variable displayed y-axis. label character vector labels treatment group. control group label specified last element vector. x_breaks numeric vector x-axis breaks. Default NULL, uses default ggplot2 x-axis breaks presentation. color Color treatment group. shape Shape treatment group. Default circle square. Input values either character numeric value, details, see https://ggplot2.tidyverse.org/articles/ggplot2-specs.html. title Panel title. Default \"AE (%)\". background_color Plot background color. Default c(\"#69B8F7\", \"#FFFFFF\"), pastel blue white. value argument used input background_color argument background_panel(). background_alpha Opacity background. Default 0.3. value argument input background_alpha argument background_panel(). theme Panel theme, including y-axis text, ticks, plot margin. Default theme_panel(show_text = TRUE, show_ticks = TRUE). details, refer theme_panel. legend_nrow Integer, number rows legend display. Must smaller equal number treatment groups. omit legend, set NULL. Default 1.","code":""},{"path":"https://merck.github.io/forestly/reference/plot_dot.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Dot plot — plot_dot","text":"AEs incidence plot item treatment group.","code":""},{"path":"https://merck.github.io/forestly/reference/plot_dot.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Dot plot — plot_dot","text":"","code":"forestly_adsl$TRTA <- factor(   forestly_adsl$TRT01A,   levels = c(\"Xanomeline Low Dose\", \"Placebo\"),   labels = c(\"Low Dose\", \"Placebo\") ) forestly_adae$TRTA <- factor(   forestly_adae$TRTA,   levels = c(\"Xanomeline Low Dose\", \"Placebo\"),   labels = c(\"Low Dose\", \"Placebo\") )  meta <- meta_forestly(   dataset_adsl = forestly_adsl,   dataset_adae = forestly_adae,   population_term = \"apat\",   observation_term = \"wk12\",   parameter_term = \"any;rel;ser\" ) |>   prepare_ae_forestly() |>   format_ae_forestly()  meta_any <- meta$tbl[1:20, ] |> dplyr::filter(parameter == \"any\") meta_any |>   dplyr::select(name, prop_1, prop_2) |>   plot_dot(\"name\", label = c(\"Treatment\", \"Placebo\"))"},{"path":"https://merck.github.io/forestly/reference/plot_errorbar.html","id":null,"dir":"Reference","previous_headings":"","what":"Plot to display risk difference — plot_errorbar","title":"Plot to display risk difference — plot_errorbar","text":"Create plot display risk difference item.","code":""},{"path":"https://merck.github.io/forestly/reference/plot_errorbar.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Plot to display risk difference — plot_errorbar","text":"","code":"plot_errorbar(   tbl,   y_var,   errbar_width = 0.4,   color = NULL,   shape = NULL,   label,   x_breaks = NULL,   grp_abbrev = \"paired\",   favor_direction = \"negative\",   vline = NULL,   line_type = 1,   title = \"Risk Diff. + 95% CI \\n (Percentage Points)\",   background_color = c(\"#69B8F7\", \"#FFFFFF\"),   background_alpha = 0.3,   theme = theme_panel(show_text = TRUE, show_ticks = TRUE),   legend_nrow = 1 )"},{"path":"https://merck.github.io/forestly/reference/plot_errorbar.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Plot to display risk difference — plot_errorbar","text":"tbl data frame selected input data set display plot. y x variables required. y_var character string specifies variable displayed y-axis. errbar_width numeric value define error bar width. Default 0.4. Value argument half length error bar, example, errorbar_width = 0.2 means half error bar width 0.2 unit length. y = 4, error bar range y = 3.8 y = 4.2. color Color treatment group. shape Shape treatment group. Default circle square. Input values either character numeric value, details, see https://ggplot2.tidyverse.org/articles/ggplot2-specs.html. label character vector labels treatment group. control group label specified last element vector. x_breaks numeric vector x-axis breaks. Default NULL, uses default ggplot2 x-axis breaks presentation. grp_abbrev character vector displaying treatment groups favor bar. grp_abbrev = \"paired\", treatment label error bar label argument. grp_abbrev = \"none\", error bar shown. Also, customized terms, users can provide alternative vector treatment labels. Default \"paired\". favor_direction position favor label condition \"comparison treatment – control\". AEs, favor_direction \"negative\"; efficacy, favor_direction \"positive\". vline Vertical reference line position. Default NULL. Users can define one multiple numeric values vector reference line position. line_type Reference line type. Default solid line. Users can define one multiple line types vector (can numeric 1, 2, 3 character \"solid\", \"dashed\"). values recycled order consistent argument vline. title Plot title. Default \"Risk Diff. + 95% CI \\\\n (Percentage Points)\". background_color Plot background color. Default c(\"#69B8F7\", \"#FFFFFF\"), pastel blue white. value argument used input background_color argument background_panel(). background_alpha Opacity background. Default 0.3. value argument input background_alpha argument background_panel(). theme Panel theme, including y-axis text, ticks, plot margin. Default theme_panel(show_text = TRUE, show_ticks = TRUE). details, refer theme_panel. legend_nrow Integer, number rows legend display. Must smaller equal number treatment groups. omit legend, set NULL. Default 1.","code":""},{"path":"https://merck.github.io/forestly/reference/plot_errorbar.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Plot to display risk difference — plot_errorbar","text":"risk difference plot item.","code":""},{"path":"https://merck.github.io/forestly/reference/plot_errorbar.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Plot to display risk difference — plot_errorbar","text":"","code":"forestly_adsl$TRTA <- factor(   forestly_adsl$TRT01A,   levels = c(\"Xanomeline Low Dose\", \"Placebo\"),   labels = c(\"Low Dose\", \"Placebo\") ) forestly_adae$TRTA <- factor(   forestly_adae$TRTA,   levels = c(\"Xanomeline Low Dose\", \"Placebo\"),   labels = c(\"Low Dose\", \"Placebo\") )  meta <- meta_forestly(   dataset_adsl = forestly_adsl,   dataset_adae = forestly_adae,   population_term = \"apat\",   observation_term = \"wk12\",   parameter_term = \"any;rel;ser\" ) |>   prepare_ae_forestly() |>   format_ae_forestly()  meta_any <- meta$tbl[1:20, ] |> dplyr::filter(parameter == \"any\") meta_any |>   dplyr::select(name, diff_1, lower_1, upper_1) |>   plot_errorbar(     y_var = \"name\",     label = c(\"Treatment\", \"Placebo\")   )"},{"path":"https://merck.github.io/forestly/reference/prepare_ae_forestly.html","id":null,"dir":"Reference","previous_headings":"","what":"Prepare datasets for interactive forest plot — prepare_ae_forestly","title":"Prepare datasets for interactive forest plot — prepare_ae_forestly","text":"Prepare datasets interactive forest plot","code":""},{"path":"https://merck.github.io/forestly/reference/prepare_ae_forestly.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Prepare datasets for interactive forest plot — prepare_ae_forestly","text":"","code":"prepare_ae_forestly(   meta,   population = NULL,   observation = NULL,   parameter = NULL,   reference_group = NULL,   ae_listing_display = c(\"USUBJID\", \"SITEID\", \"SEX\", \"RACE\", \"AGE\", \"ASTDY\", \"AESER\",     \"AEREL\", \"AEACN\", \"AEOUT\", \"ADURN\", \"ADURU\"),   ae_listing_unique = FALSE )"},{"path":"https://merck.github.io/forestly/reference/prepare_ae_forestly.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Prepare datasets for interactive forest plot — prepare_ae_forestly","text":"meta metadata object created metalite. population character value population term name. term name used key link information. observation character value observation term name. term name used key link information. parameter character value parameter term name. term name used key link information. reference_group integer indicate reference group. Default 2 2 groups, otherwise, default 1. ae_listing_display vector name variables used display AE listing table. ae_listing_unique logical value display unique records AE listing table.","code":""},{"path":"https://merck.github.io/forestly/reference/prepare_ae_forestly.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Prepare datasets for interactive forest plot — prepare_ae_forestly","text":"outdata object.","code":""},{"path":"https://merck.github.io/forestly/reference/prepare_ae_forestly.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Prepare datasets for interactive forest plot — prepare_ae_forestly","text":"","code":"adsl <- forestly_adsl[1:100,] adae <- forestly_adae[1:100,] meta_forestly(   dataset_adsl = adsl,   dataset_adae = adae ) |>   prepare_ae_forestly() #> Warning: In observation level data, force group variable 'TRTA' be a factor #> Warning: In observation level data, force group variable 'TRTA' be a factor #> List of 17 #>  $ meta           :List of 7 #>  $ population     : chr \"apat\" #>  $ observation    : chr \"safety\" #>  $ parameter      : chr \"any;rel\" #>  $ n              :'data.frame':\t60 obs. of  3 variables: #>  $ order          : num [1:60] 1008 1009 2019 2021 2022 ... #>  $ group          : chr [1:3] \"Placebo\" \"Xanomeline Low Dose\" \"Total\" #>  $ reference_group: num 2 #>  $ parameter_order: Factor w/ 2 levels \"any\",\"rel\": 1 1 1 1 1 1 1 1 1 1 ... #>  $ prop           :'data.frame':\t60 obs. of  3 variables: #>  $ diff           :'data.frame':\t60 obs. of  1 variable: #>  $ n_pop          :'data.frame':\t1 obs. of  3 variables: #>  $ name           : chr [1:60] \"Atrioventricular block second degree\" \"Bundle branch block left\" \"Eye allergy\" \"Eye pruritus\" ... #>  $ ci_lower       :'data.frame':\t60 obs. of  1 variable: #>  $ ci_upper       :'data.frame':\t60 obs. of  1 variable: #>  $ p              :'data.frame':\t60 obs. of  1 variable: #>  $ ae_listing     :'data.frame':\t151 obs. of  14 variables:"},{"path":"https://merck.github.io/forestly/reference/table_panel.html","id":null,"dir":"Reference","previous_headings":"","what":"Create table panel ggplot2 object for rainfall or forest plot — table_panel","title":"Create table panel ggplot2 object for rainfall or forest plot — table_panel","text":"Creates table panel ggplot2 object rainfall forest plot.","code":""},{"path":"https://merck.github.io/forestly/reference/table_panel.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Create table panel ggplot2 object for rainfall or forest plot — table_panel","text":"","code":"table_panel(   tbl,   y_var,   x_label = NULL,   text_color = NULL,   text_size = 8,   text_format_by = \"column\",   background_color = c(\"#69B8F7\", \"#FFFFFF\"),   theme = theme_panel(show_ticks = TRUE, show_text = TRUE),   background_alpha = 0.3 )"},{"path":"https://merck.github.io/forestly/reference/table_panel.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Create table panel ggplot2 object for rainfall or forest plot — table_panel","text":"tbl data frame displayed table. y_var string variable name tbl y axis variable. x_label Labels displayed top table column table. Default NULL, variable name display label. text_color Defines colors display treatment group. text_size Numeric font size data column. Default 8 column. text_format_by option formatting data columns rows. Default \"column\" text color varied column. text_format_by = \"row\", text color varied row. text_format_by = \"group\", text color varied treatment group. background_color Color plot background. Default c(\"#69B8F7\", \"#FFFFFF\") pastel blue white. value argument input value background_color argument background_panel(). theme Controls display y axis text, ticks plot margin. default, theme_panel(show_text = TRUE, show_ticks = TRUE) used. Users suggested use theme_panel(). background_alpha Opacity background. Default 0.3. value argument input value background_alpha argument background_panel().","code":""},{"path":"https://merck.github.io/forestly/reference/table_panel.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Create table panel ggplot2 object for rainfall or forest plot — table_panel","text":"ggplot2 object table panel.","code":""},{"path":"https://merck.github.io/forestly/reference/table_panel.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Create table panel ggplot2 object for rainfall or forest plot — table_panel","text":"","code":"forestly_adsl$TRTA <- factor(   forestly_adsl$TRT01A,   levels = c(\"Xanomeline Low Dose\", \"Placebo\"),   labels = c(\"Low Dose\", \"Placebo\") ) forestly_adae$TRTA <- factor(   forestly_adae$TRTA,   levels = c(\"Xanomeline Low Dose\", \"Placebo\"),   labels = c(\"Low Dose\", \"Placebo\") )  meta <- meta_forestly(   dataset_adsl = forestly_adsl,   dataset_adae = forestly_adae,   population_term = \"apat\",   observation_term = \"wk12\",   parameter_term = \"any;rel;ser\" ) |>   prepare_ae_forestly() |>   format_ae_forestly()  meta_any <- meta$tbl[1:20, ] |> dplyr::filter(parameter == \"any\")  meta_any |>   dplyr::select(name, diff_1, lower_1, upper_1) |>   table_panel(y_var = \"name\")"},{"path":"https://merck.github.io/forestly/reference/theme_panel.html","id":null,"dir":"Reference","previous_headings":"","what":"Theme function for plot with multiple panels — theme_panel","title":"Theme function for plot with multiple panels — theme_panel","text":"Specifies theme plot multiple panels.","code":""},{"path":"https://merck.github.io/forestly/reference/theme_panel.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Theme function for plot with multiple panels — theme_panel","text":"","code":"theme_panel(show_text = TRUE, show_ticks = TRUE)"},{"path":"https://merck.github.io/forestly/reference/theme_panel.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Theme function for plot with multiple panels — theme_panel","text":"show_text logical value controls text display y axis. Default TRUE. show_ticks logical value controls ticks display y axis. Default TRUE.","code":""},{"path":"https://merck.github.io/forestly/reference/theme_panel.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Theme function for plot with multiple panels — theme_panel","text":"Theme specific panel.","code":""},{"path":"https://merck.github.io/forestly/reference/theme_panel.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Theme function for plot with multiple panels — theme_panel","text":"","code":"library(ggplot2)  p <- ggplot(mpg, aes(displ, hwy, colour = class)) +   geom_point()  p  p + theme_panel()"},{"path":"https://merck.github.io/forestly/news/index.html","id":"forestly-011","dir":"Changelog","previous_headings":"","what":"forestly 0.1.1","title":"forestly 0.1.1","text":"Fix bug record selected AE category (#9). Fix bug multiple plots displayed one page (#12). Update dataset forestly_adae since variable factor unexpected.","code":""},{"path":"https://merck.github.io/forestly/news/index.html","id":"forestly-010","dir":"Changelog","previous_headings":"","what":"forestly 0.1.0","title":"forestly 0.1.0","text":"CRAN release: 2023-07-19 Initial version. Added NEWS.md file track changes package.","code":""}]
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Definitions","title":"GNU General Public License","text":"“License” refers version 3 GNU General Public License. “Copyright” also means copyright-like laws apply kinds works, semiconductor masks. “Program” refers copyrightable work licensed License. licensee addressed “”. “Licensees” “recipients” may individuals organizations. “modify” work means copy adapt part work fashion requiring copyright permission, making exact copy. resulting work called “modified version” earlier work work “based ” earlier work. “covered work” means either unmodified Program work based Program. “propagate” work means anything , without permission, make directly secondarily liable infringement applicable copyright law, except executing computer modifying private copy. Propagation includes copying, distribution (without modification), making available public, countries activities well. “convey” work means kind propagation enables parties make receive copies. 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Program specifies certain numbered version GNU General Public License “later version” applies , option following terms conditions either numbered version later version published Free Software Foundation. Program specify version number GNU General Public License, may choose version ever published Free Software Foundation. Program specifies proxy can decide future versions GNU General Public License can used, proxy’s public statement acceptance version permanently authorizes choose version Program. Later license versions may give additional different permissions. However, additional obligations imposed author copyright holder result choosing follow later version.","code":""},{"path":"https://merck.github.io/forestly/LICENSE.html","id":"id_15-disclaimer-of-warranty","dir":"","previous_headings":"TERMS AND CONDITIONS","what":"15. Disclaimer of Warranty","title":"GNU General Public License","text":"WARRANTY PROGRAM, EXTENT PERMITTED APPLICABLE LAW. EXCEPT OTHERWISE STATED WRITING COPYRIGHT HOLDERS /PARTIES PROVIDE PROGRAM “” WITHOUT WARRANTY KIND, EITHER EXPRESSED IMPLIED, INCLUDING, LIMITED , IMPLIED WARRANTIES MERCHANTABILITY FITNESS PARTICULAR PURPOSE. ENTIRE RISK QUALITY PERFORMANCE PROGRAM . PROGRAM PROVE DEFECTIVE, ASSUME COST NECESSARY SERVICING, REPAIR CORRECTION.","code":""},{"path":"https://merck.github.io/forestly/LICENSE.html","id":"id_16-limitation-of-liability","dir":"","previous_headings":"TERMS AND CONDITIONS","what":"16. Limitation of Liability","title":"GNU General Public License","text":"EVENT UNLESS REQUIRED APPLICABLE LAW AGREED WRITING COPYRIGHT HOLDER, PARTY MODIFIES /CONVEYS PROGRAM PERMITTED , LIABLE DAMAGES, INCLUDING GENERAL, SPECIAL, INCIDENTAL CONSEQUENTIAL DAMAGES ARISING USE INABILITY USE PROGRAM (INCLUDING LIMITED LOSS DATA DATA RENDERED INACCURATE LOSSES SUSTAINED THIRD PARTIES FAILURE PROGRAM OPERATE PROGRAMS), EVEN HOLDER PARTY ADVISED POSSIBILITY DAMAGES.","code":""},{"path":"https://merck.github.io/forestly/LICENSE.html","id":"id_17-interpretation-of-sections-15-and-16","dir":"","previous_headings":"TERMS AND CONDITIONS","what":"17. Interpretation of Sections 15 and 16","title":"GNU General Public License","text":"disclaimer warranty limitation liability provided given local legal effect according terms, reviewing courts shall apply local law closely approximates absolute waiver civil liability connection Program, unless warranty assumption liability accompanies copy Program return fee. END TERMS CONDITIONS","code":""},{"path":"https://merck.github.io/forestly/LICENSE.html","id":"how-to-apply-these-terms-to-your-new-programs","dir":"","previous_headings":"","what":"How to Apply These Terms to Your New Programs","title":"GNU General Public License","text":"develop new program, want greatest possible use public, best way achieve make free software everyone can redistribute change terms. , attach following notices program. safest attach start source file effectively state exclusion warranty; file least “copyright” line pointer full notice found. Also add information contact electronic paper mail. program terminal interaction, make output short notice like starts interactive mode: hypothetical commands show w show c show appropriate parts General Public License. course, program’s commands might different; GUI interface, use “box”. also get employer (work programmer) school, , sign “copyright disclaimer” program, necessary. information , apply follow GNU GPL, see <http://www.gnu.org/licenses/>. GNU General Public License permit incorporating program proprietary programs. program subroutine library, may consider useful permit linking proprietary applications library. want , use GNU Lesser General Public License instead License. first, please read <http://www.gnu.org/philosophy/--lgpl.html>.","code":"<one line to give the program's name and a brief idea of what it does.> Copyright (C) <year>  <name of author>  This program is free software: you can redistribute it and/or modify it under the terms of the GNU General Public License as published by the Free Software Foundation, either version 3 of the License, or (at your option) any later version.  This program is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the GNU General Public License for more details.  You should have received a copy of the GNU General Public License along with this program.  If not, see <http://www.gnu.org/licenses/>. <program>  Copyright (C) <year>  <name of author> This program comes with ABSOLUTELY NO WARRANTY; for details type 'show w'. This is free software, and you are welcome to redistribute it under certain conditions; type 'show c' for details."},{"path":"https://merck.github.io/forestly/articles/design-pattern.html","id":"overview","dir":"Articles","previous_headings":"","what":"Overview","title":"Design Plan of R Package forestly","text":"forestly package developed generate interactive forest plot safety analysis clinical trials. generate interactive forest plot, develop three main functions listed . details three main functions introduced next three sections separately. tidy_ae_table: function used obtain adverse event (AE) information ready visualization. download_ae_reports: function used generate download button, users can download AE summary tables clicking button. forestly: function used generate interactive forest plot. minimal example summarized major steps using forestly package ","code":"mydata <- tidy_ae_table(...)    # Step 1: create tidy AE data download_ae_reports(mydata)     # Step 2: generate download button forestly(mydata)                # Step 3: generate interactive forest plot                                 # (the order of Step 2 and Step 3 can be reversed)"},{"path":"https://merck.github.io/forestly/articles/design-pattern.html","id":"main-function-1-tidy_ae_table","dir":"Articles","previous_headings":"","what":"Main function 1: tidy_ae_table()","title":"Design Plan of R Package forestly","text":"main function tidy_ae_table() used obtain AE information ready visualization. Specifically speaking, merges standardized adsl adae tables together, outputs AE summary table. AE summary table summarizes number/ratio subjects experiencing certain AE treatment arm control arm. utility functions developed inside tidy_ae_table() list follows. tidy_population(): function used prepare observation datasets use function tidy_ae_table(). function filter adsl dataset, define proper treatment order dataset. tidy_observation(): function used prepare observation datasets use function tidy_ae_table(). function filter adae dataset, define proper treatment order dataset. `prop_test_mn(): function tests equal proportion using Miettinen Nurminen method. forestly package, generates confidence interval (CI) risk difference treatment arm control arm. define_ae_selectList(): function specify AE labels displayed select list interactive forestly plot. two arguments, (1) ae_criterion (2) ae_label. first argument ae_criterion (vector ) string, defines criterion select class AE display interactive forest plot. example, ae_criterion = 'AESER == \"Y\"', select serious AE. second argument ae_label (vector ) string, defines labels displayed select list interactive forest plot. two arguments string vectors, must 1:1 map. function used arguments ae_interested = function tidy_ae_table() (see examples ). throws errors length ae_criterion doesn’t match ae_label. tidy_multi_ae_label(): function design rbind data together according interested AE labels defined ae_interested =. example, use Example 1 , tidy_multi_ae_label() generate AE summary table rbind(summary table AE, summary serious AE). tidy_ae_listing(): function generates data frame serves listed details reactable.","code":"# Example 1: if you would like to display the serious AE tidy_ae_table(...,               ae_interested = define_ae_selectList(ae_criterion = 'AESER == \"Y\"',                                                    ae_label = \"serious AE\"),               ...).  # Example 2: if you would like to display both serious AE and drug-related AE tidy_ae_table(...,               ae_interested = define_ae_selectList(ae_criterion = c('AESER != \"N\"', 'AEREL != \"None\"'),                                                    ae_label = c(\"serious AE\", \"drug-related AE\")               ...)."},{"path":"https://merck.github.io/forestly/articles/design-pattern.html","id":"main-function-2-tlf_download","dir":"Articles","previous_headings":"","what":"Main function 2: tlf_download()","title":"Design Plan of R Package forestly","text":"function generates download button users download AE tables. Example: https://merck.github.io/r2rtf/articles/example-ae-summary.html tlf_ae_specific: function create specific AE table. tlf_ae_listing: function create AE listing. output tlf_xxx functions r2rtf objects created rtf_encode tlf_download: function download multiple TLFs Rmarkdown. Rewrite ae_download_report allow use tlf_xxx functions input.","code":"tlf_ae_summary()   # generate the AE summary table tlf_ae_specific()  # generate the specific AE table # tlf[[4]] <- tlf_ae_listing()   # As needed ????  tlf_download()    # download the above tables"},{"path":"https://merck.github.io/forestly/articles/design-pattern.html","id":"main-function-3-forestly","dir":"Articles","previous_headings":"","what":"Main function 3: forestly()","title":"Design Plan of R Package forestly","text":"function generates interactive forest plot returned objected tidy_ae_table(). interactive forstly plot, consists two blocks. first block select list. items listed select list specified ae_label = function tidy_ae_table(..., ae_interested = , ...). clicking different AE labels, different reactable generated. example, click “serious AE”, reactable display serious AE summary table. main tool develop block crosstalk::filter_select(). second block reactable. reactable summarizes AE information selected AE label. main tool develop block reactable::reactable(). utility functions used develop forestly() listed follows. forestly_design_details(): function returns design details reactable forest plot, including design details cell two proportions; design details cell CI; design details footer two proportions; design details footer CI. design details returned another utility function sparkline_point_js(), introduce details later. generate design details, users need specify elements design, including color: color two proportion/CI plot (see arguments fig_prop_color = fig_diff_color =); label: labels displayed two proportion/CI plot (see arguments fig_prop_label = fig_diff_label =); column width: column width two proportion/CI plot (see arguments fig_prop_colwidth = fig_diff_colwidth =); range: x-axis range plot two proportion/CI plot (see arguments fig_prop_range = fig_diff_range =). sparkline_point_js(): function generates Javascript rendered. used design details reactables, including cell footer. dependence files path forestly/inst/js/sparkline.js. mk_reactable(): function used create data table tabular data sorting pagination default. Essentially, wrapper function reactable() robust BAAMR usage. dependence R package reactable.","code":""},{"path":"https://merck.github.io/forestly/articles/design-pattern.html","id":"other-utility-filesfunctions","dir":"Articles","previous_headings":"","what":"Other utility files/functions","title":"Design Plan of R Package forestly","text":"important_functions.R: used declare R-package dependency functions used develop functions.","code":""},{"path":"https://merck.github.io/forestly/articles/forestly.html","id":"overview","dir":"Articles","previous_headings":"","what":"Overview","title":"Interactive Forest Plot","text":"forestly package creates interactive forest plots clinical trial analysis & reporting. Specific adverse events analysis Subgroup analysis assume ADaM datasets ready analysis leverage metalite data structure define inputs outputs.","code":"forestly_adsl$TRTA <- factor(forestly_adsl$TRT01A, levels = c(\"Xanomeline Low Dose\", \"Placebo\"), labels = c(\"Low Dose\", \"Placebo\"))  forestly_adae$TRTA <- factor(forestly_adae$TRTA, levels = c(\"Xanomeline Low Dose\", \"Placebo\"), labels = c(\"Low Dose\", \"Placebo\")) meta_forestly(   dataset_adsl = forestly_adsl,   dataset_adae = forestly_adae,   parameter_term = \"any;rel;ser\" ) |>   prepare_ae_forestly() |>   format_ae_forestly() |>   ae_forestly()"},{"path":"https://merck.github.io/forestly/articles/forestly.html","id":"interactive-features","dir":"Articles","previous_headings":"","what":"Interactive features","title":"Interactive Forest Plot","text":"interactive features example include: Select different AE criteria. Filter incidence AE one group. Revealed information hovering mouse point. Search bars find subjects selected adverse events (AE). Sort value click column header. Drill-listing clicking \\(\\blacktriangleright\\).","code":""},{"path":"https://merck.github.io/forestly/articles/forestly.html","id":"workflow","dir":"Articles","previous_headings":"","what":"Workflow","title":"Interactive Forest Plot","text":"general workflow : meta_forestly() constructs input metadata treatment analysis ADaM datasets. prepare_ae_forestly() prepares datasets interactive forest plot. format_ae_forestly() formats output layout. ae_forestly() generates interactive forest plot. meta_forestly() wrapper function metalite package. function users simplify process define input parameters required generate interactive forest plot. meta_forestly function require dataset_adsl, dataset_adae, observation_term population_term arguments. dataset_adsl, dataset_adae input ADaM dataset population observation. example, use “apat” population_term “wk12” observation_term. subset creteria terms, using SAFFL == \"Y\" default meta_forestly(). user wants customize definitions terms define new terms, tutorials can found link. paramter level metadata, parameter_term selected predefined terms listed . default, choose three parameter terms rel, ser use “;” concatenate allow three types AE displayed one interactive forest plot. following example, define ITT subset criteria ITTFL == \"Y\"population TEAE subset criteria TRTEMFL == \"Y\" observation. parameter, choose ser nonser pre-defined parameter list. metadata defined, can create interactive forest plot . section, calculate statistics prepare plotting dataset using prepare_ae_forestly(). Argument parameter required since can select parameter one defined metadata. use format_ae_forestly() format output ae_forestly() create interactive forest plot. Default value used arguments two functions. first example, select , ser nonser. example select , rel ser.","code":"meta_forestly(   dataset_adsl = forestly_adsl,   dataset_adae = forestly_adae,   parameter_term = \"any;rel;ser\" ) #> ADaM metadata:  #>    .$data_population     Population data with 170 subjects  #>    .$data_observation    Observation data with 736 records  #>    .$plan    Analysis plan with 1 plans  #>  #>  #>   Analysis population type: #>     name        id  group var       subset label #> 1 'apat' 'USUBJID' 'TRTA'     SAFFL == 'Y'    '' #>  #>  #>   Analysis observation type: #>       name        id  group var       subset label #> 1 'safety' 'USUBJID' 'TRTA'     SAFFL == 'Y'    '' #>  #>  #>   Analysis parameter type: #>    name                         label                     subset #> 1 'any'          'any adverse events'                            #> 2 'rel' 'drug-related adverse events' toupper(AREL) == 'RELATED' #> 3 'ser'      'serious adverse events'               AESER == 'Y' #>  #>  #>   Analysis function: #>            name                     label #> 1 'ae_forestly' 'Interactive forest plot' meta <- meta_forestly(   dataset_adsl = forestly_adsl,   dataset_adae = forestly_adae,   population_term = \"ITT\",   population_subset = ITTFL == \"Y\",   observation_term = \"TEAE\",   observation_subset = TRTEMFL == \"Y\",   parameter_term = \"any;ser;nonser;rel\" ) meta #> ADaM metadata:  #>    .$data_population     Population data with 170 subjects  #>    .$data_observation    Observation data with 736 records  #>    .$plan    Analysis plan with 1 plans  #>  #>  #>   Analysis population type: #>    name        id  group var       subset label #> 1 'ITT' 'USUBJID' 'TRTA'     ITTFL == 'Y'    '' #>  #>  #>   Analysis observation type: #>     name        id  group var         subset label #> 1 'TEAE' 'USUBJID' 'TRTA'     TRTEMFL == 'Y'    '' #>  #>  #>   Analysis parameter type: #>       name                         label                      subset #> 1    'any'          'any adverse events'                             #> 2    'ser'      'serious adverse events'                AESER == 'Y' #> 3 'nonser'  'non-serious adverse events' AESER != 'Y' | is.na(AESER) #> 4    'rel' 'drug-related adverse events'  toupper(AREL) == 'RELATED' #>  #>  #>   Analysis function: #>            name                     label #> 1 'ae_forestly' 'Interactive forest plot' meta |>   prepare_ae_forestly(parameter = \"any;ser;nonser\") |>   format_ae_forestly() |>   ae_forestly() meta |>   prepare_ae_forestly(parameter = \"any;rel;ser\") |>   format_ae_forestly() |>   ae_forestly()"},{"path":"https://merck.github.io/forestly/articles/forestly.html","id":"define-metadata","dir":"Articles","previous_headings":"","what":"Define metadata","title":"Interactive Forest Plot","text":"order provide flexibility different analysis, forestly package also allows way construct metadata. show simplified example metalite package. details can found metalite package website. start construct metadata using metalite. output metadata contains two observation wk12 period1 illustration purpose. Also, parameter, subset criteria AEREL %% c(\"POSSIBLE\", \"PROBABLE\") instead toupper(AREL) == \"RELATED\" order fit observation dataset. metadata defined, can create interactive forest plot wk12 . Using similar approach, create interactive forest plot period1.","code":"library(metalite) meta <- meta_adam(   population = forestly_adsl,   observation = forestly_adae ) |>   define_plan(plan = plan(     analysis = \"ae_forestly\",     population = \"apat\",     observation = c(\"wk12\", \"period1\"),     parameter = \"any;rel;ser\"   )) |>   define_population(     name = \"apat\",     group = \"TRTA\",     subset = quote(SAFFL == \"Y\")   ) |>   define_observation(     name = \"wk12\",     group = \"TRTA\",     subset = quote(SAFFL == \"Y\"),     label = \"Weeks 0 to 12\"   ) |>   define_observation(     name = \"period1\",     group = \"TRTA\",     var = \"AEDECOD\",     subset = quote(TRTEMFL == \"Y\" & SAFFL == \"Y\"),     label = \"Period 1\"   ) |>   define_parameter(     name = \"rel\",     subset = quote(AEREL %in% c(\"POSSIBLE\", \"PROBABLE\"))   ) |>   define_analysis(     name = \"ae_forestly\",     label = \"Interactive forest plot\"   ) |>   meta_build() meta #> ADaM metadata:  #>    .$data_population     Population data with 170 subjects  #>    .$data_observation    Observation data with 736 records  #>    .$plan    Analysis plan with 2 plans  #>  #>  #>   Analysis population type: #>     name        id  group var       subset                         label #> 1 'apat' 'USUBJID' 'TRTA'     SAFFL == 'Y' 'All Participants as Treated' #>  #>  #>   Analysis observation type: #>        name        id  group       var                        subset #> 1    'wk12' 'USUBJID' 'TRTA'                            SAFFL == 'Y' #> 2 'period1' 'USUBJID' 'TRTA' 'AEDECOD' TRTEMFL == 'Y' & SAFFL == 'Y' #>             label #> 1 'Weeks 0 to 12' #> 2      'Period 1' #>  #>  #>   Analysis parameter type: #>    name                         label                               subset #> 1 'rel' 'drug-related adverse events' AEREL %in% c('POSSIBLE', 'PROBABLE') #> 2 'any'          'any adverse events'                                      #> 3 'ser'      'serious adverse events'                         AESER == 'Y' #>  #>  #>   Analysis function: #>            name                     label #> 1 'ae_forestly' 'Interactive forest plot' meta |>   prepare_ae_forestly(     population = \"apat\",     observation = \"wk12\",     parameter = \"any;rel;ser\"   ) |>   format_ae_forestly() |>   ae_forestly() meta |>   prepare_ae_forestly(     population = \"apat\",     observation = \"period1\",     parameter = \"any;rel;ser\"   ) |>   format_ae_forestly() |>   ae_forestly()"},{"path":"https://merck.github.io/forestly/articles/layout.html","id":"overview","dir":"Articles","previous_headings":"","what":"Overview","title":"Controlling Layout","text":"forestly package controls forest plot layouts simple effective approach. illustrate idea, use ADSL (forestly_adsl_3grp) ADAE (forestly_adae_3grp) datasets forestly package contain three treatment groups. first step create required metadata using meta_forestly(). use prepare_ae_forestly() prepare input datasets interactive forest plot. outdata contains parameters required generate interactive forest plot. interactive forest plot default style can generated.","code":"metadata <- meta_forestly(   dataset_adsl = forestly_adsl_3grp,   dataset_adae = forestly_adae_3grp,   parameter_term = \"any;rel;ser\" )  outdata <- metadata |> prepare_ae_forestly()  outdata #> List of 18 #>  $ meta           :List of 7 #>  $ population     : chr \"apat\" #>  $ observation    : chr \"safety\" #>  $ parameter      : chr \"any;rel;ser\" #>  $ n              :'data.frame': 402 obs. of  4 variables: #>  $ order          : num [1:402] 1000 1030 1031 1032 1033 ... #>  $ group          : chr [1:4] \"Placebo\" \"Low Dose\" \"High Dose\" \"Total\" #>  $ reference_group: num 1 #>  $ parameter_order: Factor w/ 3 levels \"any\",\"rel\",\"ser\": 1 1 1 1 1 1 1 1 1 1 ... #>  $ prop           :'data.frame': 402 obs. of  4 variables: #>  $ diff           :'data.frame': 402 obs. of  2 variables: #>  $ n_pop          :'data.frame': 1 obs. of  4 variables: #>  $ name           : chr [1:402] \"Cardiac disorders\" \"Atrial fibrillation\" \"Atrial flutter\" \"Atrial hypertrophy\" ... #>  $ soc_name       : chr [1:402] \"Cardiac disorders\" \"CARDIAC DISORDERS\" \"CARDIAC DISORDERS\" \"CARDIAC DISORDERS\" ... #>  $ ci_lower       :'data.frame': 402 obs. of  2 variables: #>  $ ci_upper       :'data.frame': 402 obs. of  2 variables: #>  $ p              :'data.frame': 402 obs. of  2 variables: #>  $ ae_listing     :'data.frame': 1898 obs. of  14 variables: outdata |>   format_ae_forestly() |>   ae_forestly()"},{"path":"https://merck.github.io/forestly/articles/layout.html","id":"change-color","dir":"Articles","previous_headings":"","what":"Change color","title":"Controlling Layout","text":"default, forestly using teal treatment group plum control group. user wants change color, color argument format_ae_forestly() function can used. example interactive forest plot using black grey.","code":"outdata |>   format_ae_forestly(color = c(\"black\", \"grey60\", \"grey40\")) |>   ae_forestly()"},{"path":"https://merck.github.io/forestly/articles/layout.html","id":"display-different-columns","dir":"Articles","previous_headings":"","what":"Display different columns","title":"Controlling Layout","text":"using display argument format_ae_forestly(), can display total column. can also display risk difference columns similar approach.","code":"outdata |>   format_ae_forestly(display = c(\"n\", \"prop\", \"fig_prop\", \"fig_diff\", \"total\")) |>   ae_forestly() outdata |>   format_ae_forestly(display = c(\"n\", \"prop\", \"fig_prop\", \"fig_diff\", \"diff\")) |>   ae_forestly()"},{"path":"https://merck.github.io/forestly/articles/layout.html","id":"control-column-width","dir":"Articles","previous_headings":"","what":"Control column width","title":"Controlling Layout","text":"can control column width customize layout.","code":"outdata |>   format_ae_forestly(     width_fig = 230,     footer_space = 110   ) |>   ae_forestly(width = 1000)"},{"path":"https://merck.github.io/forestly/articles/layout.html","id":"horizontal-scrolling","dir":"Articles","previous_headings":"","what":"Horizontal scrolling","title":"Controlling Layout","text":"Set ae_forestly(..., width = NULL) make element scrollable horizontally. particularly useful embedding plot pages responsive design, using frameworks Bootstrap.","code":""},{"path":"https://merck.github.io/forestly/articles/layout.html","id":"change-variable-listed-in-drill-down-table","dir":"Articles","previous_headings":"","what":"Change variable listed in drill-down table","title":"Controlling Layout","text":"Users can explore AE listing clicking \\(\\blacktriangleright\\) row specify column names ae_listing_display.","code":"listing_var <- c(   \"SEX\", \"RACE\", \"AGE\",   \"SITEID\", \"AESEV\", \"STUDYID\",   \"AESER\", \"AEREL\", \"ASTDT\", \"AENDT\" )  metadata |>   prepare_ae_forestly(     ae_listing_display = listing_var   ) |>   format_ae_forestly() |>   ae_forestly()"},{"path":"https://merck.github.io/forestly/articles/layout.html","id":"hide-filters","dir":"Articles","previous_headings":"","what":"Hide filters","title":"Controlling Layout","text":"can use simple CSS rules hide incidence rate filter element. example, R Markdown document, use:","code":"```{css, echo=FALSE} #filter_subject {   display: none; } ```"},{"path":"https://merck.github.io/forestly/authors.html","id":null,"dir":"","previous_headings":"","what":"Authors","title":"Authors and Citation","text":"Yilong Zhang. Author. Benjamin Wang. Author, maintainer. Yujie Zhao. Author. Nan Xiao. Contributor. Hiroaki Fukuda. Contributor. Yulia Sidi. Contributor. Xuan Deng. Contributor. Merck & Co., Inc., Rahway, NJ, USA affiliates. Copyright holder.","code":""},{"path":"https://merck.github.io/forestly/authors.html","id":"citation","dir":"","previous_headings":"","what":"Citation","title":"Authors and Citation","text":"Zhang Y, Wang B, Zhao Y (2024). forestly: Interactive Forest Plot. R package version 0.1.1, https://github.com/Merck/forestly, https://merck.github.io/forestly/.","code":"@Manual{,   title = {forestly: Interactive Forest Plot},   author = {Yilong Zhang and Benjamin Wang and Yujie Zhao},   year = {2024},   note = {R package version 0.1.1, https://github.com/Merck/forestly},   url = {https://merck.github.io/forestly/}, }"},{"path":[]},{"path":"https://merck.github.io/forestly/index.html","id":"installation","dir":"","previous_headings":"","what":"Installation","title":"Interactive Forest Plot","text":"easiest way get forestly install CRAN: Alternatively, use new feature get bug fix, can install development version forestly GitHub:","code":"install.packages(\"forestly\") # install.packages(\"remotes\") remotes::install_github(\"Merck/forestly\")"},{"path":"https://merck.github.io/forestly/index.html","id":"overview","dir":"","previous_headings":"","what":"Overview","title":"Interactive Forest Plot","text":"forestly package creates interactive forest plots clinical trial analysis & reporting. Specific adverse events analysis Subgroup analysis assume ADaM datasets ready analysis leverage metalite data structure define inputs outputs.","code":""},{"path":"https://merck.github.io/forestly/index.html","id":"workflow","dir":"","previous_headings":"","what":"Workflow","title":"Interactive Forest Plot","text":"general workflow : meta_forestly() constructs input metadata treatment analysis ADaM datasets. prepare_ae_forestly() prepares datasets interactive forest plot. format_ae_forestly() formats output layout. ae_forestly() generates interactive forest plot. quick example","code":"library(\"forestly\")  meta_forestly(   forestly_adsl,   forestly_adae ) |>   prepare_ae_forestly(parameter = \"any;rel;ser\") |>   format_ae_forestly() |>   ae_forestly()"},{"path":"https://merck.github.io/forestly/index.html","id":"interactive-features","dir":"","previous_headings":"","what":"Interactive features","title":"Interactive Forest Plot","text":"interactive features safety analysis include: Select different AE criteria. Filter incidence AE one groups. Reveal information hovering mouse data point. Search bars find subjects selected adverse events (AEs). Sort value clicking column header. Drill-listing clicking ▸.","code":""},{"path":"https://merck.github.io/forestly/index.html","id":"references","dir":"","previous_headings":"","what":"References","title":"Interactive Forest Plot","text":"Paper: 2023 PHUSE US Connect Talk: 2021 R/Pharma Conference","code":""},{"path":"https://merck.github.io/forestly/reference/ae_forestly.html","id":null,"dir":"Reference","previous_headings":"","what":"Display interactive forest plot — ae_forestly","title":"Display interactive forest plot — ae_forestly","text":"Display interactive forest plot","code":""},{"path":"https://merck.github.io/forestly/reference/ae_forestly.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Display interactive forest plot — ae_forestly","text":"","code":"ae_forestly(   outdata,   display_soc_toggle = TRUE,   filter = c(\"prop\", \"n\"),   width = 1400 )"},{"path":"https://merck.github.io/forestly/reference/ae_forestly.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Display interactive forest plot — ae_forestly","text":"outdata outdata object created format_ae_forestly(). display_soc_toggle boolean value display SOC toggle button. filter character value filter variable. width numeric value width table pixels.","code":""},{"path":"https://merck.github.io/forestly/reference/ae_forestly.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Display interactive forest plot — ae_forestly","text":"AE forest plot saved shiny.tag.list object.","code":""},{"path":"https://merck.github.io/forestly/reference/ae_forestly.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Display interactive forest plot — ae_forestly","text":"","code":"adsl <- forestly_adsl[1:100, ] adae <- forestly_adae[1:100, ] if (interactive()) {   meta_forestly(     dataset_adsl = adsl,     dataset_adae = adae,   ) |>     prepare_ae_forestly() |>     format_ae_forestly() |>     ae_forestly() }"},{"path":"https://merck.github.io/forestly/reference/background_panel.html","id":null,"dir":"Reference","previous_headings":"","what":"Add background for creating plot with customized color — background_panel","title":"Add background for creating plot with customized color — background_panel","text":"Creates colored background panels rainfall forest plot.","code":""},{"path":"https://merck.github.io/forestly/reference/background_panel.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Add background for creating plot with customized color — background_panel","text":"","code":"background_panel(   g,   background_color = c(\"#69B8F7\", \"#FFFFFF\"),   background_alpha = 0.3 )"},{"path":"https://merck.github.io/forestly/reference/background_panel.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Add background for creating plot with customized color — background_panel","text":"g ggplot object adding colored background. background_color vector colors defines color plot background. Default c(\"#69B8F7\", \"#FFFFFF\"), pastel blue white. colors recycled. background_alpha Opacity geom. Default 0.3.","code":""},{"path":"https://merck.github.io/forestly/reference/background_panel.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Add background for creating plot with customized color — background_panel","text":"Plot colored background add panels rainfall forest plot.","code":""},{"path":"https://merck.github.io/forestly/reference/background_panel.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Add background for creating plot with customized color — background_panel","text":"","code":"library(ggplot2)  df <- data.frame(   study = c(\"S1\", \"S2\", \"S3\", \"S4\", \"S5\", \"S6\", \"S7\"),   item = as.factor(1:7),   effect = c(-.4, -.25, -.1, .1, .15, .2, .3),   lower = c(-.43, -.29, -.17, -.02, .04, .17, .27),   upper = c(-.37, -.21, -.03, .22, .24, .23, .33) )  ggplot(data = df) |>   background_panel(background_color = c(\"grey\", \"white\"), background_alpha = 0.4) +   geom_point(aes(y = item, x = effect)) +   geom_errorbar(aes(y = item, x = effect, xmin = lower, xmax = upper), width = 0.4) +   scale_y_discrete(name = \"\", breaks = 1:nrow(df), labels = df$study)"},{"path":"https://merck.github.io/forestly/reference/forestly_adae.html","id":null,"dir":"Reference","previous_headings":"","what":"An adverse event dataset — forestly_adae","title":"An adverse event dataset — forestly_adae","text":"dataset containing adverse event information clinical trial following CDISC ADaM standard.","code":""},{"path":"https://merck.github.io/forestly/reference/forestly_adae.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"An adverse event dataset — forestly_adae","text":"","code":"forestly_adae"},{"path":"https://merck.github.io/forestly/reference/forestly_adae.html","id":"format","dir":"Reference","previous_headings":"","what":"Format","title":"An adverse event dataset — forestly_adae","text":"data frame 736 rows 56 variables.","code":""},{"path":"https://merck.github.io/forestly/reference/forestly_adae.html","id":"source","dir":"Reference","previous_headings":"","what":"Source","title":"An adverse event dataset — forestly_adae","text":"https://github.com/phuse-org/phuse-scripts/tree/master/data/adam/cdisc","code":""},{"path":"https://merck.github.io/forestly/reference/forestly_adae.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"An adverse event dataset — forestly_adae","text":"Definition variable can found https://github.com/phuse-org/phuse-scripts/tree/master/data/adam/cdisc.","code":""},{"path":"https://merck.github.io/forestly/reference/forestly_adae_3grp.html","id":null,"dir":"Reference","previous_headings":"","what":"An adverse event dataset — forestly_adae_3grp","title":"An adverse event dataset — forestly_adae_3grp","text":"dataset containing adverse event information clinical trial following CDISC ADaM standard.","code":""},{"path":"https://merck.github.io/forestly/reference/forestly_adae_3grp.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"An adverse event dataset — forestly_adae_3grp","text":"","code":"forestly_adae_3grp"},{"path":"https://merck.github.io/forestly/reference/forestly_adae_3grp.html","id":"format","dir":"Reference","previous_headings":"","what":"Format","title":"An adverse event dataset — forestly_adae_3grp","text":"data frame 1191 rows 56 variables.","code":""},{"path":"https://merck.github.io/forestly/reference/forestly_adae_3grp.html","id":"source","dir":"Reference","previous_headings":"","what":"Source","title":"An adverse event dataset — forestly_adae_3grp","text":"https://github.com/phuse-org/phuse-scripts/tree/master/data/adam/cdisc","code":""},{"path":"https://merck.github.io/forestly/reference/forestly_adae_3grp.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"An adverse event dataset — forestly_adae_3grp","text":"Definition variable can found https://github.com/phuse-org/phuse-scripts/tree/master/data/adam/cdisc.","code":""},{"path":"https://merck.github.io/forestly/reference/forestly_adsl.html","id":null,"dir":"Reference","previous_headings":"","what":"A subject level demographic dataset — forestly_adsl","title":"A subject level demographic dataset — forestly_adsl","text":"dataset containing demographic information clinical trial following CDISC ADaM standard.","code":""},{"path":"https://merck.github.io/forestly/reference/forestly_adsl.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"A subject level demographic dataset — forestly_adsl","text":"","code":"forestly_adsl"},{"path":"https://merck.github.io/forestly/reference/forestly_adsl.html","id":"format","dir":"Reference","previous_headings":"","what":"Format","title":"A subject level demographic dataset — forestly_adsl","text":"data frame 170 rows 49 variables.","code":""},{"path":"https://merck.github.io/forestly/reference/forestly_adsl.html","id":"source","dir":"Reference","previous_headings":"","what":"Source","title":"A subject level demographic dataset — forestly_adsl","text":"https://github.com/phuse-org/phuse-scripts/tree/master/data/adam/cdisc","code":""},{"path":"https://merck.github.io/forestly/reference/forestly_adsl.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"A subject level demographic dataset — forestly_adsl","text":"Definition variable can found https://github.com/phuse-org/phuse-scripts/tree/master/data/adam/cdisc.","code":""},{"path":"https://merck.github.io/forestly/reference/forestly_adsl_3grp.html","id":null,"dir":"Reference","previous_headings":"","what":"A subject level demographic dataset — forestly_adsl_3grp","title":"A subject level demographic dataset — forestly_adsl_3grp","text":"dataset containing demographic information clinical trial following CDISC ADaM standard.","code":""},{"path":"https://merck.github.io/forestly/reference/forestly_adsl_3grp.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"A subject level demographic dataset — forestly_adsl_3grp","text":"","code":"forestly_adsl_3grp"},{"path":"https://merck.github.io/forestly/reference/forestly_adsl_3grp.html","id":"format","dir":"Reference","previous_headings":"","what":"Format","title":"A subject level demographic dataset — forestly_adsl_3grp","text":"data frame 254 rows 49 variables.","code":""},{"path":"https://merck.github.io/forestly/reference/forestly_adsl_3grp.html","id":"source","dir":"Reference","previous_headings":"","what":"Source","title":"A subject level demographic dataset — forestly_adsl_3grp","text":"https://github.com/phuse-org/phuse-scripts/tree/master/data/adam/cdisc","code":""},{"path":"https://merck.github.io/forestly/reference/forestly_adsl_3grp.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"A subject level demographic dataset — forestly_adsl_3grp","text":"Definition variable can found https://github.com/phuse-org/phuse-scripts/tree/master/data/adam/cdisc.","code":""},{"path":"https://merck.github.io/forestly/reference/format_ae_forestly.html","id":null,"dir":"Reference","previous_headings":"","what":"Format outdata for interactive forest plot — format_ae_forestly","title":"Format outdata for interactive forest plot — format_ae_forestly","text":"Format outdata interactive forest plot","code":""},{"path":"https://merck.github.io/forestly/reference/format_ae_forestly.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Format outdata for interactive forest plot — format_ae_forestly","text":"","code":"format_ae_forestly(   outdata,   display = c(\"n\", \"prop\", \"fig_prop\", \"fig_diff\"),   digits = 1,   width_term = 200,   width_fig = 320,   width_n = 40,   width_prop = 60,   width_diff = 80,   footer_space = 90,   color = NULL,   diff_label = \"Treatment <- Favor -> Placebo\",   show_ae_parameter = FALSE )"},{"path":"https://merck.github.io/forestly/reference/format_ae_forestly.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Format outdata for interactive forest plot — format_ae_forestly","text":"outdata outdata object created prepare_ae_forestly(). display character vector measurement displayed. n: Number subjects AE. prop: Proportion subjects AE. total: Total columns. diff: Risk difference. digits value digits displayed proportion risk difference. width_term Width px AE term column. width_fig Width px proportion risk difference figure. width_n Width px \"N\" columns. width_prop Width px \"(%)\" columns. width_diff Width px risk difference columns. footer_space Space px footer display legend. color vector colors analysis groups. Default value supports 4 groups. diff_label x-axis label risk difference. show_ae_parameter boolean value display AE parameter column.","code":""},{"path":"https://merck.github.io/forestly/reference/format_ae_forestly.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Format outdata for interactive forest plot — format_ae_forestly","text":"outdata object.","code":""},{"path":"https://merck.github.io/forestly/reference/format_ae_forestly.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Format outdata for interactive forest plot — format_ae_forestly","text":"","code":"adsl <- forestly_adsl[1:100,] adae <- forestly_adae[1:100,] meta_forestly(   dataset_adsl = adsl,   dataset_adae = adae ) |>   prepare_ae_forestly()|>   format_ae_forestly() #> Warning: In observation level data, force group variable 'TRTA' be a factor #> Warning: In observation level data, force group variable 'TRTA' be a factor #> List of 25 #>  $ meta                   :List of 7 #>  $ population             : chr \"apat\" #>  $ observation            : chr \"safety\" #>  $ parameter              : chr \"any;rel\" #>  $ n                      :'data.frame':\t79 obs. of  3 variables: #>  $ order                  : num [1:79] 1000 1008 1009 2000 2019 ... #>  $ group                  : chr [1:3] \"Placebo\" \"Xanomeline Low Dose\" \"Total\" #>  $ reference_group        : num 2 #>  $ parameter_order        : Factor w/ 2 levels \"any\",\"rel\": 1 1 1 1 1 1 1 1 1 1 ... #>  $ prop                   :'data.frame':\t79 obs. of  3 variables: #>  $ diff                   :'data.frame':\t79 obs. of  1 variable: #>  $ n_pop                  :'data.frame':\t1 obs. of  3 variables: #>  $ name                   : chr [1:79] \"Cardiac disorders\" \"Atrioventricular block second degree\" \"Bundle branch block left\" \"Eye disorders\" ... #>  $ soc_name               : chr [1:79] \"Cardiac disorders\" \"CARDIAC DISORDERS\" \"CARDIAC DISORDERS\" \"Eye disorders\" ... #>  $ ci_lower               :'data.frame':\t79 obs. of  1 variable: #>  $ ci_upper               :'data.frame':\t79 obs. of  1 variable: #>  $ p                      :'data.frame':\t79 obs. of  1 variable: #>  $ ae_listing             :'data.frame':\t151 obs. of  14 variables: #>  $ tbl                    :'data.frame':\t79 obs. of  14 variables: #>  $ reactable_columns      :List of 14 #>  $ reactable_columns_group:List of 3 #>  $ display                : chr [1:4] \"n\" \"prop\" \"fig_prop\" \"fig_diff\" #>  $ fig_prop_color         : chr [1:2] \"#00857C\" \"#66203A\" #>  $ fig_diff_color         : chr \"#00857C\" #>  $ hidden_column          : chr [1:6] \"parameter\" \"diff_1\" \"lower_1\" \"upper_1\" ..."},{"path":"https://merck.github.io/forestly/reference/meta_forestly.html","id":null,"dir":"Reference","previous_headings":"","what":"Create metadata for interactive forest plot — meta_forestly","title":"Create metadata for interactive forest plot — meta_forestly","text":"Create metadata interactive forest plot","code":""},{"path":"https://merck.github.io/forestly/reference/meta_forestly.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Create metadata for interactive forest plot — meta_forestly","text":"","code":"meta_forestly(   dataset_adsl,   dataset_adae,   population_term = \"apat\",   observation_term = \"safety\",   parameter_term = \"any;rel\",   population_subset = SAFFL == \"Y\",   observation_subset = SAFFL == \"Y\",   treatment_group = \"TRTA\" )"},{"path":"https://merck.github.io/forestly/reference/meta_forestly.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Create metadata for interactive forest plot — meta_forestly","text":"dataset_adsl ADSL source dataset. dataset_adae ADAE source dataset. population_term character value population term name. observation_term character value observation term name. parameter_term character value parameter term name. population_subset unquoted condition selecting populations ADSL dataset. observation_subset unquoted condition selecting observations ADAE dataset. treatment_group character value treatment group name.","code":""},{"path":"https://merck.github.io/forestly/reference/meta_forestly.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Create metadata for interactive forest plot — meta_forestly","text":"metalite object.","code":""},{"path":"https://merck.github.io/forestly/reference/meta_forestly.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Create metadata for interactive forest plot — meta_forestly","text":"","code":"meta_forestly(   forestly_adsl,   forestly_adae,   population_term = \"apat\",   observation_term = \"safety\",   parameter_term = \"any;rel\" ) #> ADaM metadata:  #>    .$data_population \tPopulation data with 170 subjects  #>    .$data_observation \tObservation data with 736 records  #>    .$plan \tAnalysis plan with 1 plans  #>  #>  #>   Analysis population type: #>     name        id  group var       subset label #> 1 'apat' 'USUBJID' 'TRTA'     SAFFL == 'Y'    '' #>  #>  #>   Analysis observation type: #>       name        id  group var       subset label #> 1 'safety' 'USUBJID' 'TRTA'     SAFFL == 'Y'    '' #>  #>  #>   Analysis parameter type: #>    name                         label                     subset #> 1 'any'          'any adverse events'                            #> 2 'rel' 'drug-related adverse events' toupper(AREL) == 'RELATED' #>  #>  #>   Analysis function: #>            name                     label #> 1 'ae_forestly' 'Interactive forest plot' #>"},{"path":"https://merck.github.io/forestly/reference/plot_dot.html","id":null,"dir":"Reference","previous_headings":"","what":"Dot plot — plot_dot","title":"Dot plot — plot_dot","text":"Create dot plot item. instance, used create AEs incidence plot Preferred Term treatment group, part rainfall plot.","code":""},{"path":"https://merck.github.io/forestly/reference/plot_dot.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Dot plot — plot_dot","text":"","code":"plot_dot(   tbl,   y_var,   label,   x_breaks = NULL,   color = NULL,   shape = NULL,   title = \"AE (%)\",   background_color = c(\"#69B8F7\", \"#FFFFFF\"),   background_alpha = 0.3,   theme = theme_panel(show_text = TRUE, show_ticks = TRUE),   legend_nrow = 1 )"},{"path":"https://merck.github.io/forestly/reference/plot_dot.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Dot plot — plot_dot","text":"tbl data frame selected input data set display plot. y x variables required. y_var character string specifies variable displayed y-axis. label character vector labels treatment group. control group label specified last element vector. x_breaks numeric vector x-axis breaks. Default NULL, uses default ggplot2 x-axis breaks presentation. color Color treatment group. shape Shape treatment group. Default circle square. Input values either character numeric value, details, see https://ggplot2.tidyverse.org/articles/ggplot2-specs.html. title Panel title. Default \"AE (%)\". background_color Plot background color. Default c(\"#69B8F7\", \"#FFFFFF\"), pastel blue white. value argument used input background_color argument background_panel(). background_alpha Opacity background. Default 0.3. value argument input background_alpha argument background_panel(). theme Panel theme, including y-axis text, ticks, plot margin. Default theme_panel(show_text = TRUE, show_ticks = TRUE). details, refer theme_panel. legend_nrow Integer, number rows legend display. Must smaller equal number treatment groups. omit legend, set NULL. Default 1.","code":""},{"path":"https://merck.github.io/forestly/reference/plot_dot.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Dot plot — plot_dot","text":"AEs incidence plot item treatment group.","code":""},{"path":"https://merck.github.io/forestly/reference/plot_dot.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Dot plot — plot_dot","text":"","code":"forestly_adsl$TRTA <- factor(   forestly_adsl$TRT01A,   levels = c(\"Xanomeline Low Dose\", \"Placebo\"),   labels = c(\"Low Dose\", \"Placebo\") ) forestly_adae$TRTA <- factor(   forestly_adae$TRTA,   levels = c(\"Xanomeline Low Dose\", \"Placebo\"),   labels = c(\"Low Dose\", \"Placebo\") )  meta <- meta_forestly(   dataset_adsl = forestly_adsl,   dataset_adae = forestly_adae,   population_term = \"apat\",   observation_term = \"wk12\",   parameter_term = \"any;rel;ser\" ) |>   prepare_ae_forestly() |>   format_ae_forestly()  meta_any <- meta$tbl[1:20, ] |> dplyr::filter(parameter == \"any\") meta_any |>   dplyr::select(name, prop_1, prop_2) |>   plot_dot(\"name\", label = c(\"Treatment\", \"Placebo\"))"},{"path":"https://merck.github.io/forestly/reference/plot_errorbar.html","id":null,"dir":"Reference","previous_headings":"","what":"Plot to display risk difference — plot_errorbar","title":"Plot to display risk difference — plot_errorbar","text":"Create plot display risk difference item.","code":""},{"path":"https://merck.github.io/forestly/reference/plot_errorbar.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Plot to display risk difference — plot_errorbar","text":"","code":"plot_errorbar(   tbl,   y_var,   errbar_width = 0.4,   color = NULL,   shape = NULL,   label,   x_breaks = NULL,   grp_abbrev = \"paired\",   favor_direction = \"negative\",   vline = NULL,   line_type = 1,   title = \"Risk Diff. + 95% CI \\n (Percentage Points)\",   background_color = c(\"#69B8F7\", \"#FFFFFF\"),   background_alpha = 0.3,   theme = theme_panel(show_text = TRUE, show_ticks = TRUE),   legend_nrow = 1 )"},{"path":"https://merck.github.io/forestly/reference/plot_errorbar.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Plot to display risk difference — plot_errorbar","text":"tbl data frame selected input data set display plot. y x variables required. y_var character string specifies variable displayed y-axis. errbar_width numeric value define error bar width. Default 0.4. Value argument half length error bar, example, errorbar_width = 0.2 means half error bar width 0.2 unit length. y = 4, error bar range y = 3.8 y = 4.2. color Color treatment group. shape Shape treatment group. Default circle square. Input values either character numeric value, details, see https://ggplot2.tidyverse.org/articles/ggplot2-specs.html. label character vector labels treatment group. control group label specified last element vector. x_breaks numeric vector x-axis breaks. Default NULL, uses default ggplot2 x-axis breaks presentation. grp_abbrev character vector displaying treatment groups favor bar. grp_abbrev = \"paired\", treatment label error bar label argument. grp_abbrev = \"none\", error bar shown. Also, customized terms, users can provide alternative vector treatment labels. Default \"paired\". favor_direction position favor label condition \"comparison treatment – control\". AEs, favor_direction \"negative\"; efficacy, favor_direction \"positive\". vline Vertical reference line position. Default NULL. Users can define one multiple numeric values vector reference line position. line_type Reference line type. Default solid line. Users can define one multiple line types vector (can numeric 1, 2, 3 character \"solid\", \"dashed\"). values recycled order consistent argument vline. title Plot title. Default \"Risk Diff. + 95% CI \\\\n (Percentage Points)\". background_color Plot background color. Default c(\"#69B8F7\", \"#FFFFFF\"), pastel blue white. value argument used input background_color argument background_panel(). background_alpha Opacity background. Default 0.3. value argument input background_alpha argument background_panel(). theme Panel theme, including y-axis text, ticks, plot margin. Default theme_panel(show_text = TRUE, show_ticks = TRUE). details, refer theme_panel. legend_nrow Integer, number rows legend display. Must smaller equal number treatment groups. omit legend, set NULL. Default 1.","code":""},{"path":"https://merck.github.io/forestly/reference/plot_errorbar.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Plot to display risk difference — plot_errorbar","text":"risk difference plot item.","code":""},{"path":"https://merck.github.io/forestly/reference/plot_errorbar.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Plot to display risk difference — plot_errorbar","text":"","code":"forestly_adsl$TRTA <- factor(   forestly_adsl$TRT01A,   levels = c(\"Xanomeline Low Dose\", \"Placebo\"),   labels = c(\"Low Dose\", \"Placebo\") ) forestly_adae$TRTA <- factor(   forestly_adae$TRTA,   levels = c(\"Xanomeline Low Dose\", \"Placebo\"),   labels = c(\"Low Dose\", \"Placebo\") )  meta <- meta_forestly(   dataset_adsl = forestly_adsl,   dataset_adae = forestly_adae,   population_term = \"apat\",   observation_term = \"wk12\",   parameter_term = \"any;rel;ser\" ) |>   prepare_ae_forestly() |>   format_ae_forestly()  meta_any <- meta$tbl[1:20, ] |> dplyr::filter(parameter == \"any\") meta_any |>   dplyr::select(name, diff_1, lower_1, upper_1) |>   plot_errorbar(     y_var = \"name\",     label = c(\"Treatment\", \"Placebo\")   )"},{"path":"https://merck.github.io/forestly/reference/prepare_ae_forestly.html","id":null,"dir":"Reference","previous_headings":"","what":"Prepare datasets for interactive forest plot — prepare_ae_forestly","title":"Prepare datasets for interactive forest plot — prepare_ae_forestly","text":"Prepare datasets interactive forest plot","code":""},{"path":"https://merck.github.io/forestly/reference/prepare_ae_forestly.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Prepare datasets for interactive forest plot — prepare_ae_forestly","text":"","code":"prepare_ae_forestly(   meta,   population = NULL,   observation = NULL,   parameter = NULL,   reference_group = NULL,   ae_listing_display = c(\"USUBJID\", \"SITEID\", \"SEX\", \"RACE\", \"AGE\", \"ASTDY\", \"AESER\",     \"AEREL\", \"AEACN\", \"AEOUT\", \"ADURN\", \"ADURU\"),   ae_listing_unique = FALSE )"},{"path":"https://merck.github.io/forestly/reference/prepare_ae_forestly.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Prepare datasets for interactive forest plot — prepare_ae_forestly","text":"meta metadata object created metalite. population character value population term name. term name used key link information. observation character value observation term name. term name used key link information. parameter character value parameter term name. term name used key link information. reference_group integer indicate reference group. Default 2 2 groups, otherwise, default 1. ae_listing_display vector name variables used display AE listing table. ae_listing_unique logical value display unique records AE listing table.","code":""},{"path":"https://merck.github.io/forestly/reference/prepare_ae_forestly.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Prepare datasets for interactive forest plot — prepare_ae_forestly","text":"outdata object.","code":""},{"path":"https://merck.github.io/forestly/reference/prepare_ae_forestly.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Prepare datasets for interactive forest plot — prepare_ae_forestly","text":"","code":"adsl <- forestly_adsl[1:100,] adae <- forestly_adae[1:100,] meta_forestly(   dataset_adsl = adsl,   dataset_adae = adae ) |>   prepare_ae_forestly() #> Warning: In observation level data, force group variable 'TRTA' be a factor #> Warning: In observation level data, force group variable 'TRTA' be a factor #> List of 18 #>  $ meta           :List of 7 #>  $ population     : chr \"apat\" #>  $ observation    : chr \"safety\" #>  $ parameter      : chr \"any;rel\" #>  $ n              :'data.frame':\t79 obs. of  3 variables: #>  $ order          : num [1:79] 1000 1008 1009 2000 2019 ... #>  $ group          : chr [1:3] \"Placebo\" \"Xanomeline Low Dose\" \"Total\" #>  $ reference_group: num 2 #>  $ parameter_order: Factor w/ 2 levels \"any\",\"rel\": 1 1 1 1 1 1 1 1 1 1 ... #>  $ prop           :'data.frame':\t79 obs. of  3 variables: #>  $ diff           :'data.frame':\t79 obs. of  1 variable: #>  $ n_pop          :'data.frame':\t1 obs. of  3 variables: #>  $ name           : chr [1:79] \"Cardiac disorders\" \"Atrioventricular block second degree\" \"Bundle branch block left\" \"Eye disorders\" ... #>  $ soc_name       : chr [1:79] \"Cardiac disorders\" \"CARDIAC DISORDERS\" \"CARDIAC DISORDERS\" \"Eye disorders\" ... #>  $ ci_lower       :'data.frame':\t79 obs. of  1 variable: #>  $ ci_upper       :'data.frame':\t79 obs. of  1 variable: #>  $ p              :'data.frame':\t79 obs. of  1 variable: #>  $ ae_listing     :'data.frame':\t151 obs. of  14 variables:"},{"path":"https://merck.github.io/forestly/reference/table_panel.html","id":null,"dir":"Reference","previous_headings":"","what":"Create table panel ggplot2 object for rainfall or forest plot — table_panel","title":"Create table panel ggplot2 object for rainfall or forest plot — table_panel","text":"Creates table panel ggplot2 object rainfall forest plot.","code":""},{"path":"https://merck.github.io/forestly/reference/table_panel.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Create table panel ggplot2 object for rainfall or forest plot — table_panel","text":"","code":"table_panel(   tbl,   y_var,   x_label = NULL,   text_color = NULL,   text_size = 8,   text_format_by = \"column\",   background_color = c(\"#69B8F7\", \"#FFFFFF\"),   theme = theme_panel(show_ticks = TRUE, show_text = TRUE),   background_alpha = 0.3 )"},{"path":"https://merck.github.io/forestly/reference/table_panel.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Create table panel ggplot2 object for rainfall or forest plot — table_panel","text":"tbl data frame displayed table. y_var string variable name tbl y axis variable. x_label Labels displayed top table column table. Default NULL, variable name display label. text_color Defines colors display treatment group. text_size Numeric font size data column. Default 8 column. text_format_by option formatting data columns rows. Default \"column\" text color varied column. text_format_by = \"row\", text color varied row. text_format_by = \"group\", text color varied treatment group. background_color Color plot background. Default c(\"#69B8F7\", \"#FFFFFF\") pastel blue white. value argument input value background_color argument background_panel(). theme Controls display y axis text, ticks plot margin. default, theme_panel(show_text = TRUE, show_ticks = TRUE) used. Users suggested use theme_panel(). background_alpha Opacity background. Default 0.3. value argument input value background_alpha argument background_panel().","code":""},{"path":"https://merck.github.io/forestly/reference/table_panel.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Create table panel ggplot2 object for rainfall or forest plot — table_panel","text":"ggplot2 object table panel.","code":""},{"path":"https://merck.github.io/forestly/reference/table_panel.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Create table panel ggplot2 object for rainfall or forest plot — table_panel","text":"","code":"forestly_adsl$TRTA <- factor(   forestly_adsl$TRT01A,   levels = c(\"Xanomeline Low Dose\", \"Placebo\"),   labels = c(\"Low Dose\", \"Placebo\") ) forestly_adae$TRTA <- factor(   forestly_adae$TRTA,   levels = c(\"Xanomeline Low Dose\", \"Placebo\"),   labels = c(\"Low Dose\", \"Placebo\") )  meta <- meta_forestly(   dataset_adsl = forestly_adsl,   dataset_adae = forestly_adae,   population_term = \"apat\",   observation_term = \"wk12\",   parameter_term = \"any;rel;ser\" ) |>   prepare_ae_forestly() |>   format_ae_forestly()  meta_any <- meta$tbl[1:20, ] |> dplyr::filter(parameter == \"any\")  meta_any |>   dplyr::select(name, diff_1, lower_1, upper_1) |>   table_panel(y_var = \"name\")"},{"path":"https://merck.github.io/forestly/reference/theme_panel.html","id":null,"dir":"Reference","previous_headings":"","what":"Theme function for plot with multiple panels — theme_panel","title":"Theme function for plot with multiple panels — theme_panel","text":"Specifies theme plot multiple panels.","code":""},{"path":"https://merck.github.io/forestly/reference/theme_panel.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Theme function for plot with multiple panels — theme_panel","text":"","code":"theme_panel(show_text = TRUE, show_ticks = TRUE)"},{"path":"https://merck.github.io/forestly/reference/theme_panel.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Theme function for plot with multiple panels — theme_panel","text":"show_text logical value controls text display y axis. Default TRUE. show_ticks logical value controls ticks display y axis. Default TRUE.","code":""},{"path":"https://merck.github.io/forestly/reference/theme_panel.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Theme function for plot with multiple panels — theme_panel","text":"Theme specific panel.","code":""},{"path":"https://merck.github.io/forestly/reference/theme_panel.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Theme function for plot with multiple panels — theme_panel","text":"","code":"library(ggplot2)  p <- ggplot(mpg, aes(displ, hwy, colour = class)) +   geom_point()  p  p + theme_panel()"},{"path":"https://merck.github.io/forestly/news/index.html","id":"forestly-011","dir":"Changelog","previous_headings":"","what":"forestly 0.1.1","title":"forestly 0.1.1","text":"Fix bug record selected AE category (#9). Fix bug multiple plots displayed one page (#12). Update dataset forestly_adae since variable factor unexpected.","code":""},{"path":"https://merck.github.io/forestly/news/index.html","id":"forestly-010","dir":"Changelog","previous_headings":"","what":"forestly 0.1.0","title":"forestly 0.1.0","text":"CRAN release: 2023-07-19 Initial version. Added NEWS.md file track changes package.","code":""}]