From 572dbc2c15b11345d6748512b7aeb3acb5aa0d95 Mon Sep 17 00:00:00 2001 From: Nicole Gay Date: Sun, 29 Sep 2024 19:40:03 -0700 Subject: [PATCH] fix figure number reference --- vignettes/key_metabolites.Rmd | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/vignettes/key_metabolites.Rmd b/vignettes/key_metabolites.Rmd index 03d642b..9abc374 100644 --- a/vignettes/key_metabolites.Rmd +++ b/vignettes/key_metabolites.Rmd @@ -40,7 +40,7 @@ knitr::opts_chunk$set( This report was motivated by this reviewer comment regarding our [*Nature* publication](https://www.nature.com/articles/s41586-023-06877-w): -**Reviewer 1:** Given the extensive collection of metabolomics data (targeted and untargeted) for so many tissues and temporal timepoints (Figure 1C) it will be interesting to explore the changes of several key cellular metabolites in addition to the KEGG pathways. For example, it will be interesting to see sex- and time-specific changes in the plasma, muscles, heart of such metabolites as glucose, pyruvate, lactate, acetate, perhaps key intermediates of glycolysis and the TCA cycle. If the data is available, it will be also interesting to characterize the changes in the energy and redox ratios, i.e. ATP/ADP, NADH/NAD+ (or individual concentrations, such as ATP). Given the central roles of these metabolites in cellular physiology/health and multiple changes in the corresponding metabolic pathways (Figure 7), it will be good to present and discuss the observed metabolic changes. +**Reviewer 1:** Given the extensive collection of metabolomics data (targeted and untargeted) for so many tissues and temporal timepoints (Figure 1C) it will be interesting to explore the changes of several key cellular metabolites in addition to the KEGG pathways. For example, it will be interesting to see sex- and time-specific changes in the plasma, muscles, heart of such metabolites as glucose, pyruvate, lactate, acetate, perhaps key intermediates of glycolysis and the TCA cycle. If the data is available, it will be also interesting to characterize the changes in the energy and redox ratios, i.e. ATP/ADP, NADH/NAD+ (or individual concentrations, such as ATP). Given the central roles of these metabolites in cellular physiology/health and multiple changes in the corresponding metabolic pathways ([Figure 6]), it will be good to present and discuss the observed metabolic changes. ```{r setup, message = FALSE, warning = FALSE} library(MotrpacRatTraining6mo)