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<p>This is the readme for the model associated with the paper:
</p><p>Mukunda CL, Narayanan R (2017) Degeneracy in the regulation of short-term
plasticity and synaptic filtering by presynaptic mechanisms. J Physiol
595:2611-2637
<br/>
<a href="http://dx.doi.org/10.1113/JP273482">http://dx.doi.org/10.1113/JP273482</a>
</p><p>This NEURON code was contributed by CL Mukunda. The NEURON simulator is freely
available from <a href="http://neuron.yale.edu">http://neuron.yale.edu</a>
</p><p>The model contains Na, KDr, KA, CaL, CaN and h-currents. AMPA receptor at the
spine has been implemented with GHK equations. Most of the .mod files were
obtained from previous studies except stp.mod, which implements
Neurotransmitter dynamics at the terminal and cleft.
</p><p>Output will be written to a "data" folder. Running the file
"BPF.hoc" generates .txt files consisting data of EPSCs at spine, voltage at
soma and terminal, Calcium concentration at the terminal, Neurotransmitter
concentration at terminal and the synaptic cleft, for 1-50 Hz frequency
stimulation. The EPSCs are inverted as per convention of inward currents being
negative. High pass and Low pass filter profiles can be simulated by plugging
in the values mentioned in the paper.
</p><p>EPSC_1.txt file is an example data generated by running BPF.hoc<p/>
Note that the mod files must be compiled prior to running BPF.hoc. If you need more help to run the model please see <br/>
<a href="https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide.cshtml">https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide.cshtml</a><br/>
The included matlab file plot_ca_data plots this data in a format similar to Figure 2 C:
<p/>
<img src="./screenshot.png" alt="screenshot" width="750">
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