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<!DOCTYPE html>
<html lang="en">
<head>
<meta charset="UTF-8">
<title>Metabolomics Workbench File Validator</title>
<link rel="stylesheet" href="styles/styles.css"/>
</head>
<body class="background">
<div>
<h1><a href="https://MoseleyBioinformaticsLab.github.io/mwFileStatusWebsite/" style="text-decoration:none;color:white;">Metabolomics Workbench File Validator</a></h1>
<p>
Last Updated: 2026-04-05 08:00:01.594111
</p>
</div>
<div>
<h2>Statistics</h2>
<p>
Number of Studies: 93<br>
Number of Analyses: 121<br>
</p>
<h3>Validation Statistics</h3>
<div class="stats__grid">
<div class="stats__grid__item">Status</div>
<div class="stats__grid__item">mwTab</div>
<div class="stats__grid__item">JSON</div>
<a href="https://0.github.io/MoseleyBioinformaticsLab/passing" class="stats__grid__item brightgreen">Passing</a>
<div class="stats__grid__item">0</div>
<div class="stats__grid__item">0</div>
<a href="https://0.github.io/MoseleyBioinformaticsLab/passing" class="stats__grid__item yellow">Warnings Only</a>
<div class="stats__grid__item">0</div>
<div class="stats__grid__item">0</div>
<a href="https://0.github.io/MoseleyBioinformaticsLab/validation_error" class="stats__grid__item orange">Validation Error</a>
<div class="stats__grid__item">85</div>
<div class="stats__grid__item">14</div>
<a href="https://0.github.io/MoseleyBioinformaticsLab/parsing_error" class="stats__grid__item red">Parsing Error</a>
<div class="stats__grid__item">36</div>
<div class="stats__grid__item">107</div>
<a href="https://0.github.io/MoseleyBioinformaticsLab/missing" class="stats__grid__item brightred">Missing</a>
<div class="stats__grid__item">0</div>
<div class="stats__grid__item">0</div>
</div>
<p></p>
<div class="stats__grid">
<div class="stats__grid__item">Validation Error Type</div>
<div class="stats__grid__item">mwTab</div>
<div class="stats__grid__item">JSON</div>
<a href="https://MoseleyBioinformaticsLab.github.io/mwFileStatusWebsite/value" class="stats__grid__item orange">Value Error</a>
<div class="stats__grid__item">81</div>
<div class="stats__grid__item">12</div>
<a href="https://MoseleyBioinformaticsLab.github.io/mwFileStatusWebsite/consistency" class="stats__grid__item orange">Consistency Error</a>
<div class="stats__grid__item">44</div>
<div class="stats__grid__item">1</div>
<a href="https://MoseleyBioinformaticsLab.github.io/mwFileStatusWebsite/format" class="stats__grid__item orange">Format Error</a>
<div class="stats__grid__item">48</div>
<div class="stats__grid__item">10</div>
</div>
<h3>mwTab vs JSON Comparison Statistics</h3>
<div class="compare__stats__grid">
<div class="stats__grid__item">Status</div>
<div class="stats__grid__item">Count</div>
<div class="stats__grid__item brightgreen">Consistent</div>
<div class="stats__grid__item">0</div>
<div class="stats__grid__item orange">Inconsistent</div>
<div class="stats__grid__item">0</div>
<div class="stats__grid__item lightgrey">Not Checked</div>
<div class="stats__grid__item">121</div>
</div>
</div>
<div>
<h2>File Status</h2>
<div class="grid header">
<input type="checkbox" id="study_grid_item0" class="study_checkbox"/>
<label for="study_grid_item0" href="#ST000020" class="study__grid__item">ST000020: Biomarker Discovery in Knee Osteoarthritis (I) - RTI International - Sumner, Susan</label>
<div class="grid__description" style="height:13em;max-height:13">
<div class="desc__grid">
<div class="desc__grid__item">STUDY_TITLE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Biomarker Discovery in Knee Osteoarthritis (I)</div>
<div class="desc__grid__item">STUDY_TYPE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Biomarker Discovery in Knee Osteoarthritis</div>
<div class="desc__grid__item">STUDY_SUMMARY</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">The goal of the study was to determine whether there is a set of metabolites that differentiate people who have knee OA and show radiographic disease progression over 18 months from those who have knee OA and do not show disease progression over the same time period.</div>
<div class="desc__grid__item">INSTITUTE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">RTI International</div>
<div class="desc__grid__item">DEPARTMENT</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Systems and Translational Sciences (STS)</div>
<div class="desc__grid__item">LABORATORY</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">NIH Eastern Regional Comprehensive Metabolomics Resource Core (RTI RCMRC)</div>
<div class="desc__grid__item">LAST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Sumner</div>
<div class="desc__grid__item">FIRST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Susan</div>
<div class="desc__grid__item">ADDRESS</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">3040 East Cornwallis Road, Research Triangle Park, NC 27709, USA.</div>
<div class="desc__grid__item">EMAIL</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">ssumner@rti.org</div>
<div class="desc__grid__item">PHONE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">919-541-7479</div>
<div class="desc__grid__item">NUM_GROUPS</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">4</div>
<div class="desc__grid__item">TOTAL_SUBJECTS</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">88</div>
</div>
</div>
</div>
<div class="grid">
<input type="checkbox" id="analysis_grid_item1" class="analysis_checkbox"/>
<label for="analysis_grid_item1" href="#AN000039" class="analysis__grid__item red">AN000039</label>
<div class="grid__description">
<div>
<span>
<div class="shield">
<div class="shieldLeft grey">
<a href="https://www.metabolomicsworkbench.org/rest/study/analysis_id/AN000039/mwtab/txt" target="_blank">txt</a>
</div>
<div class="shieldRight orange">
<a href="https://raw.githubusercontent.com/MoseleyBioinformaticsLab/mwFileStatusWebsite/master/validation_logs/AN000039_txt.log" target="_blank">Validation Error</a>
</div>
</div>
<div class="shield">
<div class="shieldLeft grey">
<a href="https://www.metabolomicsworkbench.org/rest/study/analysis_id/AN000039/mwtab/json" target="_blank">json</a>
</div>
<div class="shieldRight red">
<a href="https://raw.githubusercontent.com/MoseleyBioinformaticsLab/mwFileStatusWebsite/master/validation_logs/AN000039_json.log" target="_blank">Parsing Error</a>
</div>
</div>
<div class="shield">
<div class="shieldLeft grey">
<a href="https://www.metabolomicsworkbench.org/rest/study/analysis_id/AN000039/mwtab/comparison" target="_blank">comparison</a>
</div>
<div class="shieldRight lightgrey">
<a href="https://raw.githubusercontent.com/MoseleyBioinformaticsLab/mwFileStatusWebsite/master/validation_logs/AN000039_comparison.log" target="_blank">Not Checked</a>
</div>
</div>
</span>
</div>
<br>
<div class="desc__grid">
<div class="desc__grid__item">ANALYSIS_ID</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">AN000039</div>
</div>
</div>
</div> <br> <div class="grid header">
<input type="checkbox" id="study_grid_item1" class="study_checkbox"/>
<label for="study_grid_item1" href="#ST000045" class="study__grid__item">ST000045: Plasma metabolomics: Comparison of non-diabetic controls with T1D patients - Mayo Clinic - Nair, Sree</label>
<div class="grid__description" style="height:12em;max-height:12">
<div class="desc__grid">
<div class="desc__grid__item">STUDY_TITLE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Plasma metabolomics: Comparison of non-diabetic controls with T1D patients</div>
<div class="desc__grid__item">STUDY_TYPE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Drug effect study</div>
<div class="desc__grid__item">STUDY_SUMMARY</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Non-diabetic controls whose metabolites were compared to T1D patients with and insulin. Seven C-peptide?negative T1D subjects were studied on two occasions: during insulin treatment and the other following withdrawal of insulin for 8 h compared with matched healthy ND participants</div>
<div class="desc__grid__item">INSTITUTE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Mayo Clinic</div>
<div class="desc__grid__item">DEPARTMENT</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Endocrinology</div>
<div class="desc__grid__item">LAST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Nair</div>
<div class="desc__grid__item">FIRST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Sree</div>
<div class="desc__grid__item">ADDRESS</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">-</div>
<div class="desc__grid__item">EMAIL</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Dasari.Surendra@mayo.edu</div>
<div class="desc__grid__item">PHONE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">-</div>
<div class="desc__grid__item">NUM_GROUPS</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">1</div>
<div class="desc__grid__item">TOTAL_SUBJECTS</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">7</div>
</div>
</div>
</div>
<div class="grid">
<input type="checkbox" id="analysis_grid_item2" class="analysis_checkbox"/>
<label for="analysis_grid_item2" href="#AN000074" class="analysis__grid__item red">AN000074</label>
<div class="grid__description">
<div>
<span>
<div class="shield">
<div class="shieldLeft grey">
<a href="https://www.metabolomicsworkbench.org/rest/study/analysis_id/AN000074/mwtab/txt" target="_blank">txt</a>
</div>
<div class="shieldRight orange">
<a href="https://raw.githubusercontent.com/MoseleyBioinformaticsLab/mwFileStatusWebsite/master/validation_logs/AN000074_txt.log" target="_blank">Validation Error</a>
</div>
</div>
<div class="shield">
<div class="shieldLeft grey">
<a href="https://www.metabolomicsworkbench.org/rest/study/analysis_id/AN000074/mwtab/json" target="_blank">json</a>
</div>
<div class="shieldRight red">
<a href="https://raw.githubusercontent.com/MoseleyBioinformaticsLab/mwFileStatusWebsite/master/validation_logs/AN000074_json.log" target="_blank">Parsing Error</a>
</div>
</div>
<div class="shield">
<div class="shieldLeft grey">
<a href="https://www.metabolomicsworkbench.org/rest/study/analysis_id/AN000074/mwtab/comparison" target="_blank">comparison</a>
</div>
<div class="shieldRight lightgrey">
<a href="https://raw.githubusercontent.com/MoseleyBioinformaticsLab/mwFileStatusWebsite/master/validation_logs/AN000074_comparison.log" target="_blank">Not Checked</a>
</div>
</div>
</span>
</div>
<br>
<div class="desc__grid">
<div class="desc__grid__item">ANALYSIS_ID</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">AN000074</div>
</div>
</div>
</div> <br> <div class="grid header">
<input type="checkbox" id="study_grid_item2" class="study_checkbox"/>
<label for="study_grid_item2" href="#ST000165" class="study__grid__item">ST000165: None - None - None, None</label>
<div class="grid__description" style="height:0em;max-height:0">
<div class="desc__grid">
</div>
</div>
</div>
<div class="grid">
<input type="checkbox" id="analysis_grid_item3" class="analysis_checkbox"/>
<label for="analysis_grid_item3" href="#AN000258" class="analysis__grid__item red">AN000258</label>
<div class="grid__description">
<div>
<span>
<div class="shield">
<div class="shieldLeft grey">
<a href="https://www.metabolomicsworkbench.org/rest/study/analysis_id/AN000258/mwtab/txt" target="_blank">txt</a>
</div>
<div class="shieldRight red">
<a href="https://raw.githubusercontent.com/MoseleyBioinformaticsLab/mwFileStatusWebsite/master/validation_logs/AN000258_txt.log" target="_blank">Parsing Error</a>
</div>
</div>
<div class="shield">
<div class="shieldLeft grey">
<a href="https://www.metabolomicsworkbench.org/rest/study/analysis_id/AN000258/mwtab/json" target="_blank">json</a>
</div>
<div class="shieldRight red">
<a href="https://raw.githubusercontent.com/MoseleyBioinformaticsLab/mwFileStatusWebsite/master/validation_logs/AN000258_json.log" target="_blank">Parsing Error</a>
</div>
</div>
<div class="shield">
<div class="shieldLeft grey">
<a href="https://www.metabolomicsworkbench.org/rest/study/analysis_id/AN000258/mwtab/comparison" target="_blank">comparison</a>
</div>
<div class="shieldRight lightgrey">
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<div class="desc__grid__item">ANALYSIS_ID</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">AN000258</div>
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<label for="study_grid_item3" href="#ST000166" class="study__grid__item">ST000166: None - None - None, None</label>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">AN000259</div>
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<label for="study_grid_item4" href="#ST000253" class="study__grid__item">ST000253: None - None - None, None</label>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">AN000400</div>
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<div class="desc__grid__item">ANALYSIS_ID</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">AN000401</div>
</div>
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<input type="checkbox" id="study_grid_item5" class="study_checkbox"/>
<label for="study_grid_item5" href="#ST000254" class="study__grid__item">ST000254: The role of microbial metabolites in experimental liver disease - University of North Carolina - Sumner, Susan</label>
<div class="grid__description" style="height:12em;max-height:12">
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<div class="desc__grid__item">STUDY_TITLE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">The role of microbial metabolites in experimental liver disease</div>
<div class="desc__grid__item">STUDY_TYPE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Targeted Metabolomic Analysis of plasma samples</div>
<div class="desc__grid__item">STUDY_SUMMARY</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Aim 1: Our experimental approach is to understand the effect of drinking water supplemented bacterial metabolite, Indole-3-propionic Acid (IPA), in liver disease in an acute alcohol model. Aim 2: Determine the levels of IPA in plasma of conventional mice in a chronic alcohol model. Aim 3: Determine the levels of IPA in plasma of conventional WT (C57BL/6) and mutant SL (sublytic, which is a mouse with a point mutation in ATP4a) mice.</div>
<div class="desc__grid__item">INSTITUTE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">University of North Carolina</div>
<div class="desc__grid__item">DEPARTMENT</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Discovery Science Technology</div>
<div class="desc__grid__item">LABORATORY</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Sumner Lab</div>
<div class="desc__grid__item">LAST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Sumner</div>
<div class="desc__grid__item">FIRST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Susan</div>
<div class="desc__grid__item">ADDRESS</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Eastern Regional Comprehensive Metabolomics Resource Core, UNC Nutrition Research Institute, 500 Laureate Way, Kannapolis, NC, 28081</div>
<div class="desc__grid__item">EMAIL</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">susan_sumner @unc.edu</div>
<div class="desc__grid__item">PHONE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">704-250-5066</div>
<div class="desc__grid__item">SUBMIT_DATE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">2015-09-29</div>
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<label for="analysis_grid_item7" href="#AN000402" class="analysis__grid__item red">AN000402</label>
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<div class="desc__grid__item">ANALYSIS_ID</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">AN000402</div>
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<input type="checkbox" id="study_grid_item6" class="study_checkbox"/>
<label for="study_grid_item6" href="#ST000256" class="study__grid__item">ST000256: Signal Intensities Derived from Different NMR Probes and Parameters Contribute to Variations in Quantification of Metabolites - University of Michigan - Stringer, Kathleen</label>
<div class="grid__description" style="height:15em;max-height:15">
<div class="desc__grid">
<div class="desc__grid__item">STUDY_TITLE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Signal Intensities Derived from Different NMR Probes and Parameters Contribute to Variations in Quantification of Metabolites</div>
<div class="desc__grid__item">STUDY_TYPE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Single timepoint; healthy controls</div>
<div class="desc__grid__item">STUDY_SUMMARY</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Healthy volunteers</div>
<div class="desc__grid__item">INSTITUTE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">University of Michigan</div>
<div class="desc__grid__item">DEPARTMENT</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Clinical Pharmacy</div>
<div class="desc__grid__item">LABORATORY</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">The NMR Metabolomics Laboratory (Stringer)</div>
<div class="desc__grid__item">LAST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Stringer</div>
<div class="desc__grid__item">FIRST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Kathleen</div>
<div class="desc__grid__item">ADDRESS</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">University Michigan, 2900 Huron Parkway, Ann Arbor, MI 48105</div>
<div class="desc__grid__item">EMAIL</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">stringek@umich.edu</div>
<div class="desc__grid__item">PHONE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">--</div>
<div class="desc__grid__item">SUBMIT_DATE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">2015-09-18</div>
<div class="desc__grid__item">NUM_GROUPS</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">N/A</div>
<div class="desc__grid__item">TOTAL_SUBJECTS</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">19</div>
<div class="desc__grid__item">STUDY_COMMENTS</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Data were also generated by the University of Alberta (UA)</div>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">AN000405</div>
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<input type="checkbox" id="study_grid_item7" class="study_checkbox"/>
<label for="study_grid_item7" href="#ST000258" class="study__grid__item">ST000258: Metabolic contribution of pSymA and pSymB megaplasmid/chromid for multipartite meliloti cultured in minimal M9 medium - McMaster University - Finan, Turlough</label>
<div class="grid__description" style="height:12em;max-height:12">
<div class="desc__grid">
<div class="desc__grid__item">STUDY_TITLE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Metabolic contribution of pSymA and pSymB megaplasmid/chromid for multipartite meliloti cultured in minimal M9 medium</div>
<div class="desc__grid__item">STUDY_TYPE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">megaplasmid deletion</div>
<div class="desc__grid__item">STUDY_SUMMARY</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">To understand the contribution of pSymA and pSymB to the metabolism of S. the intracellular metabolome was analyzed at five time points (exponential and growth phases) across the growth curve of strains with or without pSymA and/or grown in a defined, minimal medium (M9).</div>
<div class="desc__grid__item">INSTITUTE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">McMaster University</div>
<div class="desc__grid__item">DEPARTMENT</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Department of Biology</div>
<div class="desc__grid__item">LAST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Finan</div>
<div class="desc__grid__item">FIRST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Turlough</div>
<div class="desc__grid__item">ADDRESS</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Department of Biology, McMaster University, Hamilton, Canada L8S4K1</div>
<div class="desc__grid__item">EMAIL</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">finan@mcmaster.ca</div>
<div class="desc__grid__item">PHONE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">(+1)905-525-9140 ext 22932</div>
<div class="desc__grid__item">NUM_GROUPS</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">20</div>
<div class="desc__grid__item">TOTAL_SUBJECTS</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">115</div>
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<label for="analysis_grid_item9" href="#AN000409" class="analysis__grid__item red">AN000409</label>
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<div class="desc__grid__item">ANALYSIS_ID</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">AN000409</div>
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</div> <br> <div class="grid header">
<input type="checkbox" id="study_grid_item8" class="study_checkbox"/>
<label for="study_grid_item8" href="#ST000267" class="study__grid__item">ST000267: Activity-Based Metabolic Profiling of M. tuberculosis H37Rv Rv3722c - Weill Cornell Medical College - Rhee, Kyu</label>
<div class="grid__description" style="height:11em;max-height:11">
<div class="desc__grid">
<div class="desc__grid__item">STUDY_TITLE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Activity-Based Metabolic Profiling of M. tuberculosis H37Rv Rv3722c</div>
<div class="desc__grid__item">STUDY_TYPE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">timecourse</div>
<div class="desc__grid__item">STUDY_SUMMARY</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">These experiments involve incubating various proteins of unknown function in M. tuberculosis genome with whole-cell lysate and assaying changes in levels over time (e.g. 0, 15, 30min) to try to infer what reaction they might</div>
<div class="desc__grid__item">INSTITUTE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Weill Cornell Medical College</div>
<div class="desc__grid__item">DEPARTMENT</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Microbiology and Immunology</div>
<div class="desc__grid__item">LAST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Rhee</div>
<div class="desc__grid__item">FIRST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Kyu</div>
<div class="desc__grid__item">ADDRESS</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Department of Microbiology and Immunology, Weill Cornell Medical College, 1300 Avenue, New York, NY</div>
<div class="desc__grid__item">EMAIL</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">kyr9001@med.cornell.edu</div>
<div class="desc__grid__item">PHONE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">-</div>
<div class="desc__grid__item">STUDY_COMMENTS</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">The timepoints in the datafiles refer the amount of time (in minutes) that each was incubated with lysate.The units for 'mzmed' are mass/charge.The units for are seconds (retention time).The units for all the other data columns in the are arbitrary; they are integrated peak counts.In this study, Rv1713 was with lysate with and without 1mM GTP added as a co-factor.</div>
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<label for="study_grid_item9" href="#ST000361" class="study__grid__item">ST000361: Characterization and Plasticity of the Metabolome in Peripheral Cells in Bipolar I Disorder - RTI - Sumner, Susan</label>
<div class="grid__description" style="height:15em;max-height:15">
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Characterization and Plasticity of the Metabolome in Peripheral Cells in Bipolar I Disorder</div>
<div class="desc__grid__item">STUDY_TYPE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Broad Spectrum LCMS</div>
<div class="desc__grid__item">STUDY_SUMMARY</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Patients with Bipolar I Disorder (BPI) and matched non-affected controls were recruited. Males and females from all races and ethnicities between the ages of 19-65 participated in the research. Skin biopsies were obtained and fibroblasts were isolated from each of these biopsies. A total of 1 x 〖10〗^7 fibroblasts cells were used for metabolomics. Cell pellets were flash frozen in liquid nitrogen and shipped on dry ice to the NIH Eastern Regional Comprehensive Metabolomic Resource Core at RTI International in North Carolina. Metabolomics will be determined using a broad spectrum metabolomics protocol by RTI</div>
<div class="desc__grid__item">INSTITUTE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">RTI</div>
<div class="desc__grid__item">DEPARTMENT</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Discovery Sciences</div>
<div class="desc__grid__item">LABORATORY</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">System and Translational Sciences</div>
<div class="desc__grid__item">LAST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Sumner</div>
<div class="desc__grid__item">FIRST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Susan</div>
<div class="desc__grid__item">ADDRESS</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">3040 Cornwallis Rd, RTP,NC</div>
<div class="desc__grid__item">EMAIL</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">ssumner@rti.org</div>
<div class="desc__grid__item">PHONE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">919-541-7479</div>
<div class="desc__grid__item">NUM_GROUPS</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">2</div>
<div class="desc__grid__item">TOTAL_SUBJECTS</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">18</div>
<div class="desc__grid__item">NUM_MALES</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">7</div>
<div class="desc__grid__item">NUM_FEMALES</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">11</div>
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<label for="study_grid_item10" href="#ST000365" class="study__grid__item">ST000365: Zebrafish Metabolomics: Model for Environmental Metal Toxicity - University of North Carolina - Sumner, Susan</label>
<div class="grid__description" style="height:11em;max-height:11">
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Zebrafish Metabolomics: Model for Environmental Metal Toxicity</div>
<div class="desc__grid__item">STUDY_SUMMARY</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">This metabolomics seed project will test the hypothesis that zebrafish can provide mechanistic insights into the human health effects of developmental exposure to Cd and Pb. We will use broad spectrum metabolomics of zebrafish larvae after exposure to Cd, Pb, and Cd and Pb compared to controls. Activity observed at 5 days post fertilization is will be used to determine if there is a correlation between biological pathways implicated by these metabolic profiles and cardiovascular, metabolic (obesity), and neurological phenotypes. The behavioral phenotypes have been quantified in zebrafish previously and have been measured in the Newborn Epigenetic STudy (NEST), a NIH-funded project that is investigating how environmental exposures and nutrition, in the womb and during childhood, affect how genes work and how these exposures developed into obesity and other diseases, disorders, and conditions. The results from this study will demonstrate the power of using zebrafish as a model for mechanism discovery in exposure using metabolomics to advance understanding of early life exposure to Cd and Pb and serve as preliminary data for opportunities.</div>
<div class="desc__grid__item">INSTITUTE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">University of North Carolina</div>
<div class="desc__grid__item">DEPARTMENT</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Discovery Sciences</div>
<div class="desc__grid__item">LABORATORY</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Sumner Lab</div>
<div class="desc__grid__item">LAST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Sumner</div>
<div class="desc__grid__item">FIRST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Susan</div>
<div class="desc__grid__item">ADDRESS</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Eastern Regional Comprehensive Metabolomics Resource Core, UNC Nutrition Research Institute, 500 Laureate Way, Kannapolis, NC, 28081</div>
<div class="desc__grid__item">EMAIL</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">susan_sumner @unc.edu</div>
<div class="desc__grid__item">PHONE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">704-250-5066</div>
<div class="desc__grid__item">SUBMIT_DATE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">2016-03-09</div>
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<label for="study_grid_item11" href="#ST000368" class="study__grid__item">ST000368: Investigation of metabolomic blood biomarkers for detection of adenocarcinoma lung cancer - University of California, Davis - Fiehn, Oliver</label>
<div class="grid__description" style="height:12em;max-height:12">
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Investigation of metabolomic blood biomarkers for detection of adenocarcinoma lung cancer</div>
<div class="desc__grid__item">STUDY_TYPE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Lung cancer case control biomarker discovery</div>
<div class="desc__grid__item">STUDY_SUMMARY</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Recently, the National Lung Cancer Screen Trial (NLST) demonstrated that low-dose CT (LDCT) screening could reduce mortality due to lung cancer by 20%. However, LDCT screening is largely hindered by high false-positive rates (96%), particularly in high-risk populations (heavy smokers), due to the low prevalence rates (less than 2%) of malignant tumors and high incidence of benign lung nodules. Consequently, complementary biomarkers that can be used in conjunction with LDCT screening to improve diagnostic capacities and reduce false-positive rates are highly desirable. Preferably, such complementary tools should be noninvasive and exhibit high sensitivity and specificity. The application of “-omic” sciences (genomics, transcriptomics, proteomics, and metabolomics) represents valuable tools for the discovery and validation of potential biomarkers that can be used for detection of NSCLC. Of these omic sciences, metabolomics has received considerable attention for its application in cancer. Metabolomics is the assessment of small molecules and biochemical intermediates (metabolites) using analytic instrumentation. Metabolites in blood are the product of all cellular processes, which are highly responsive to conditions of disease and environment, and represent the final output products of all organs forming a detailed systemic representation of an individual's current physiologic state. In this study, we used an untargeted metabolomics approach using gas chromatography time-of-flight mass spectrometry (GCTOFMS) to analyze the metabolome of serum and plasma samples both collected from the same patients that were organized into two independent case–control studies (ADC1 and ADC2). In both studies, only NSCLC adenocarcinoma was investigated. The overall objectives were to (i) determine whether individual or combinations of metabolites could be used as a diagnostic test to distinguish NSCLC adenocarcinoma from controls and (ii) to determine which, plasma or serum, provides more accurate classifiers for the detection of lung cancer. We developed individual and multimetabolite classifiers using a training test from the ADC1 study and evaluated the performance of the constructed classifiers, individually or in combination, in an independent test/validation study (ADC2). This study shows the potential of metabolite-based diagnostic tests for detection of lung adenocarcinoma. Further validation in a larger pool of samples is warranted.</div>
<div class="desc__grid__item">INSTITUTE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">University of California, Davis</div>
<div class="desc__grid__item">DEPARTMENT</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Genome and Biomedical Sciences Facility</div>
<div class="desc__grid__item">LABORATORY</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">WCMC Metabolomics Core</div>
<div class="desc__grid__item">LAST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Fiehn</div>
<div class="desc__grid__item">FIRST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Oliver</div>
<div class="desc__grid__item">ADDRESS</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">1315 Genome and Biomedical Sciences Facility, 451 Health Sciences Drive, Davis, CA 95616</div>
<div class="desc__grid__item">EMAIL</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">ofiehn@ucdavis.edu</div>
<div class="desc__grid__item">PHONE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">(530) 754-8258</div>
<div class="desc__grid__item">STUDY_COMMENTS</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">SS = Sigma sample and is used as a quality control The first set (ADC1) used for biomarker development consisted of serum and plasma samples obtained from 52 stages I–IV NSCLC adenocarcinoma patients (52 plasma and 49 serum), and 31 healthy controls (31 pairs of serum and plasma) for a total of 163 samples. This set was regarded as the training set for biomarker discovery and classifier development. A second, independent case–control study (ADC2) consisting of serum and plasma samples collected from 43 stage I–IV NSCLC adenocarcinoma patients and 43 healthy controls (total 172 samples) was used as an independent test set for biomarker evaluation. A limitation of this study is the relatively small sample size for each cohort (52 cases, 31 controls for ADC1, and 43 cases and 43 controls for ADC2) because patient variability can be a big factor in smaller studies.</div>
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<label for="study_grid_item12" href="#ST000386" class="study__grid__item">ST000386: Study 2 Investigation of metabolomic blood biomarkers for detection of adenocarcinoma lung cancer (test/validation) - University of California, Davis - Fiehn, Oliver</label>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Study 2 Investigation of metabolomic blood biomarkers for detection of adenocarcinoma lung cancer (test/validation)</div>
<div class="desc__grid__item">STUDY_SUMMARY</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Recently, the National Lung Cancer Screen Trial (NLST) demonstrated that low-dose CT (LDCT) screening could reduce mortality due to lung cancer by 20%. However, LDCT screening is largely hindered by high false-positive rates (96%), particularly in high-risk populations (heavy smokers), due to the low prevalence rates (less than 2%) of malignant tumors and high incidence of benign lung nodules. Consequently, complementary biomarkers that can be used in conjunction with LDCT screening to improve diagnostic capacities and reduce false-positive rates are highly desirable. Preferably, such complementary tools should be noninvasive and exhibit high sensitivity and specificity. The application of “-omic” sciences (genomics, transcriptomics, proteomics, and metabolomics) represents valuable tools for the discovery and validation of potential biomarkers that can be used for detection of NSCLC. Of these omic sciences, metabolomics has received considerable attention for its application in cancer. Metabolomics is the assessment of small molecules and biochemical intermediates (metabolites) using analytic instrumentation. Metabolites in blood are the product of all cellular processes, which are highly responsive to conditions of disease and environment, and represent the final output products of all organs forming a detailed systemic representation of an individual's current physiologic state. In this study, we used an untargeted metabolomics approach using gas chromatography time-of-flight mass spectrometry (GCTOFMS) to analyze the metabolome of serum and plasma samples both collected from the same patients that were organized into two independent case–control studies (ADC1 and ADC2). In both studies, only NSCLC adenocarcinoma was investigated. The overall objectives were to (i) determine whether individual or combinations of metabolites could be used as a diagnostic test to distinguish NSCLC adenocarcinoma from controls and (ii) to determine which, plasma or serum, provides more accurate classifiers for the detection of lung cancer. We developed individual and multimetabolite classifiers using a training test from the ADC1 study and evaluated the performance of the constructed classifiers, individually or in combination, in an independent test/validation study (ADC2). This study shows the potential of metabolite-based diagnostic tests for detection of lung adenocarcinoma. Further validation in a larger pool of samples is warranted.</div>
<div class="desc__grid__item">INSTITUTE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">University of California, Davis</div>
<div class="desc__grid__item">DEPARTMENT</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Genome and Biomedical Sciences Facility</div>
<div class="desc__grid__item">LABORATORY</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">WCMC Metabolomics Core</div>
<div class="desc__grid__item">LAST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Fiehn</div>
<div class="desc__grid__item">FIRST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Oliver</div>
<div class="desc__grid__item">ADDRESS</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">1315 Genome and Biomedical Sciences Facility, 451 Health Sciences Drive, Davis, CA 95616</div>
<div class="desc__grid__item">EMAIL</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">ofiehn@ucdavis.edu</div>
<div class="desc__grid__item">PHONE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">(530) 754-8258</div>
<div class="desc__grid__item">STUDY_COMMENTS</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">SS = Sigma sample and is used as a quality control The first set (ADC1) used for biomarker development consisted of serum and plasma samples obtained from 52 stages I–IV NSCLC adenocarcinoma patients (52 plasma and 49 serum), and 31 healthy controls (31 pairs of serum and plasma) for a total of 163 samples. This set was regarded as the training set for biomarker discovery and classifier development. A second, independent case–control study (ADC2) consisting of serum and plasma samples collected from 43 stage I–IV NSCLC adenocarcinoma patients and 43 healthy controls (total 172 samples) was used as an independent test set for biomarker evaluation. A limitation of this study is the relatively small sample size for each cohort (52 cases, 31 controls for ADC1, and 43 cases and 43 controls for ADC2) because patient variability can be a big factor in smaller studies.</div>
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