From 069cf1b7cf53cf8b95033ff3e58a9130273df05a Mon Sep 17 00:00:00 2001 From: sfrechen Date: Wed, 2 Dec 2020 13:43:09 +0100 Subject: [PATCH] optimize time resolutions --- Clarithromycin-Midazolam-DDI.json | 777 ++++++++++-------------------- 1 file changed, 246 insertions(+), 531 deletions(-) diff --git a/Clarithromycin-Midazolam-DDI.json b/Clarithromycin-Midazolam-DDI.json index 32c552c..f841b9c 100644 --- a/Clarithromycin-Midazolam-DDI.json +++ b/Clarithromycin-Midazolam-DDI.json @@ -1,5 +1,5 @@ { - "Version": 76, + "Version": 77, "Individuals": [ { "Name": "European (P-gp modified, CYP3A4 36 h)", @@ -87,6 +87,11 @@ "Name": "CYP3A4" }, "Parameters": [ + { + "Name": "Reference concentration", + "Value": 4.32, + "Unit": "µmol/l" + }, { "Name": "t1/2 (liver)", "Value": 36.0, @@ -94,6 +99,11 @@ "ValueOrigin": { "Source": "Unknown" } + }, + { + "Name": "t1/2 (intestine)", + "Value": 23.0, + "Unit": "h" } ] }, @@ -204,6 +214,23 @@ "Name": "ColonSigmoid", "Value": 0.00010384615385 } + ], + "Parameters": [ + { + "Name": "Reference concentration", + "Value": 1.0, + "Unit": "µmol/l" + }, + { + "Name": "t1/2 (liver)", + "Value": 36.0, + "Unit": "h" + }, + { + "Name": "t1/2 (intestine)", + "Value": 23.0, + "Unit": "h" + } ] }, { @@ -592,6 +619,16 @@ "ValueOrigin": { "Source": "Unknown" } + }, + { + "Name": "t1/2 (liver)", + "Value": 36.0, + "Unit": "h" + }, + { + "Name": "t1/2 (intestine)", + "Value": 23.0, + "Unit": "h" } ] }, @@ -635,6 +672,23 @@ "MembraneLocation": "Basolateral", "Value": 0.00064682539683 } + ], + "Parameters": [ + { + "Name": "Reference concentration", + "Value": 1.0, + "Unit": "µmol/l" + }, + { + "Name": "t1/2 (liver)", + "Value": 36.0, + "Unit": "h" + }, + { + "Name": "t1/2 (intestine)", + "Value": 23.0, + "Unit": "h" + } ] }, { @@ -749,6 +803,16 @@ "ValueOrigin": { "Source": "Unknown" } + }, + { + "Name": "t1/2 (liver)", + "Value": 36.0, + "Unit": "h" + }, + { + "Name": "t1/2 (intestine)", + "Value": 23.0, + "Unit": "h" } ] }, @@ -779,6 +843,16 @@ "ValueOrigin": { "Source": "Unknown" } + }, + { + "Name": "t1/2 (liver)", + "Value": 36.0, + "Unit": "h" + }, + { + "Name": "t1/2 (intestine)", + "Value": 23.0, + "Unit": "h" } ] }, @@ -802,6 +876,16 @@ "ValueOrigin": { "Source": "Unknown" } + }, + { + "Name": "t1/2 (liver)", + "Value": 36.0, + "Unit": "h" + }, + { + "Name": "t1/2 (intestine)", + "Value": 23.0, + "Unit": "h" } ] } @@ -3407,7 +3491,7 @@ }, { "Name": "End time", - "Value": 2.0, + "Value": 24.0, "Unit": "h", "ValueOrigin": { "Source": "Unknown" @@ -3422,25 +3506,6 @@ } } ] - }, - { - "Parameters": [ - { - "Name": "Start time", - "Value": 0.0, - "Unit": "h" - }, - { - "Name": "End time", - "Value": 24.0, - "Unit": "h" - }, - { - "Name": "Resolution", - "Value": 4.0, - "Unit": "pts/h" - } - ] } ], "Parameters": [ @@ -3710,7 +3775,8 @@ "MoleculeName": "UGT1A4" }, { - "Name": "Glomerular Filtration-Optimized" + "Name": "Glomerular Filtration-Optimized", + "SystemicProcessType": "GFR" }, { "Name": "GABRG2-Buhr 1997", @@ -3796,7 +3862,7 @@ }, { "Name": "End time", - "Value": 2.0, + "Value": 24.0, "Unit": "h", "ValueOrigin": { "Source": "Unknown" @@ -3811,31 +3877,6 @@ } } ] - }, - { - "Parameters": [ - { - "Name": "Start time", - "Value": 2.0, - "Unit": "h", - "ValueOrigin": { - "Source": "Unknown" - } - }, - { - "Name": "End time", - "Value": 20.0, - "Unit": "h", - "ValueOrigin": { - "Source": "Unknown" - } - }, - { - "Name": "Resolution", - "Value": 4.0, - "Unit": "pts/h" - } - ] } ], "Parameters": [ @@ -4105,7 +4146,8 @@ "MoleculeName": "UGT1A4" }, { - "Name": "Glomerular Filtration-Optimized" + "Name": "Glomerular Filtration-Optimized", + "SystemicProcessType": "GFR" }, { "Name": "GABRG2-Buhr 1997", @@ -4193,7 +4235,7 @@ }, { "Name": "End time", - "Value": 2.0, + "Value": 24.0, "Unit": "h", "ValueOrigin": { "Source": "Unknown" @@ -4208,31 +4250,6 @@ } } ] - }, - { - "Parameters": [ - { - "Name": "Start time", - "Value": 2.0, - "Unit": "h", - "ValueOrigin": { - "Source": "Unknown" - } - }, - { - "Name": "End time", - "Value": 8.0, - "Unit": "h", - "ValueOrigin": { - "Source": "Unknown" - } - }, - { - "Name": "Resolution", - "Value": 4.0, - "Unit": "pts/h" - } - ] } ], "Parameters": [ @@ -4501,7 +4518,8 @@ "MoleculeName": "UGT1A4" }, { - "Name": "Glomerular Filtration-Optimized" + "Name": "Glomerular Filtration-Optimized", + "SystemicProcessType": "GFR" }, { "Name": "GABRG2-Buhr 1997", @@ -4872,7 +4890,8 @@ "MoleculeName": "UGT1A4" }, { - "Name": "Glomerular Filtration-Optimized" + "Name": "Glomerular Filtration-Optimized", + "SystemicProcessType": "GFR" }, { "Name": "GABRG2-Buhr 1997", @@ -4988,7 +5007,7 @@ }, { "Name": "End time", - "Value": 148.0, + "Value": 160.0, "Unit": "h", "ValueOrigin": { "Source": "Unknown" @@ -5003,31 +5022,6 @@ } } ] - }, - { - "Parameters": [ - { - "Name": "Start time", - "Value": 148.0, - "Unit": "h", - "ValueOrigin": { - "Source": "Unknown" - } - }, - { - "Name": "End time", - "Value": 160.0, - "Unit": "h", - "ValueOrigin": { - "Source": "Unknown" - } - }, - { - "Name": "Resolution", - "Value": 4.0, - "Unit": "pts/h" - } - ] } ], "Parameters": [ @@ -5369,7 +5363,8 @@ "MoleculeName": "CYP3A4" }, { - "Name": "Renal Clearances-fitted" + "Name": "Renal Clearances-fitted", + "SystemicProcessType": "Renal" } ], "Protocol": { @@ -5416,7 +5411,8 @@ "MoleculeName": "UGT1A4" }, { - "Name": "Glomerular Filtration-Optimized" + "Name": "Glomerular Filtration-Optimized", + "SystemicProcessType": "GFR" }, { "Name": "GABRG2-Buhr 1997", @@ -5543,7 +5539,7 @@ }, { "Name": "End time", - "Value": 148.0, + "Value": 160.0, "Unit": "h", "ValueOrigin": { "Source": "Unknown" @@ -5558,31 +5554,6 @@ } } ] - }, - { - "Parameters": [ - { - "Name": "Start time", - "Value": 148.0, - "Unit": "h", - "ValueOrigin": { - "Source": "Unknown" - } - }, - { - "Name": "End time", - "Value": 160.0, - "Unit": "h", - "ValueOrigin": { - "Source": "Unknown" - } - }, - { - "Name": "Resolution", - "Value": 4.0, - "Unit": "pts/h" - } - ] } ], "Parameters": [ @@ -5924,7 +5895,8 @@ "MoleculeName": "CYP3A4" }, { - "Name": "Renal Clearances-fitted" + "Name": "Renal Clearances-fitted", + "SystemicProcessType": "Renal" } ], "Protocol": { @@ -5971,7 +5943,8 @@ "MoleculeName": "UGT1A4" }, { - "Name": "Glomerular Filtration-Optimized" + "Name": "Glomerular Filtration-Optimized", + "SystemicProcessType": "GFR" }, { "Name": "GABRG2-Buhr 1997", @@ -6104,7 +6077,7 @@ }, { "Name": "End time", - "Value": 74.25, + "Value": 96.25, "Unit": "h", "ValueOrigin": { "Source": "Unknown" @@ -6119,31 +6092,6 @@ } } ] - }, - { - "Parameters": [ - { - "Name": "Start time", - "Value": 74.25, - "Unit": "h", - "ValueOrigin": { - "Source": "Unknown" - } - }, - { - "Name": "End time", - "Value": 80.25, - "Unit": "h", - "ValueOrigin": { - "Source": "Unknown" - } - }, - { - "Name": "Resolution", - "Value": 4.0, - "Unit": "pts/h" - } - ] } ], "Parameters": [ @@ -6453,7 +6401,8 @@ "MoleculeName": "CYP3A4" }, { - "Name": "Renal Clearances-fitted" + "Name": "Renal Clearances-fitted", + "SystemicProcessType": "Renal" } ], "Protocol": { @@ -6500,7 +6449,8 @@ "MoleculeName": "UGT1A4" }, { - "Name": "Glomerular Filtration-Optimized" + "Name": "Glomerular Filtration-Optimized", + "SystemicProcessType": "GFR" }, { "Name": "GABRG2-Buhr 1997", @@ -6618,7 +6568,35 @@ }, { "Name": "End time", - "Value": 122.0, + "Value": 97.5, + "Unit": "h", + "ValueOrigin": { + "Source": "Unknown" + } + }, + { + "Name": "Resolution", + "Value": 4.0, + "Unit": "pts/h", + "ValueOrigin": { + "Source": "Unknown" + } + } + ] + }, + { + "Parameters": [ + { + "Name": "Start time", + "Value": 97.5, + "Unit": "h", + "ValueOrigin": { + "Source": "Unknown" + } + }, + { + "Name": "End time", + "Value": 121.5, "Unit": "h", "ValueOrigin": { "Source": "Unknown" @@ -6952,7 +6930,8 @@ "MoleculeName": "CYP3A4" }, { - "Name": "Renal Clearances-fitted" + "Name": "Renal Clearances-fitted", + "SystemicProcessType": "Renal" } ], "Protocol": { @@ -6999,7 +6978,8 @@ "MoleculeName": "UGT1A4" }, { - "Name": "Glomerular Filtration-Optimized" + "Name": "Glomerular Filtration-Optimized", + "SystemicProcessType": "GFR" }, { "Name": "GABRG2-Buhr 1997", @@ -7104,7 +7084,7 @@ }, { "Name": "End time", - "Value": 2.0, + "Value": 24.0, "Unit": "h" }, { @@ -7113,35 +7093,13 @@ "Unit": "pts/h" } ] - }, - { - "Parameters": [ - { - "Name": "Start time", - "Value": 2.0, - "Unit": "h" - }, - { - "Name": "End time", - "Value": 10.0, - "Unit": "h", - "ValueOrigin": { - "Source": "Unknown" - } - }, - { - "Name": "Resolution", - "Value": 4.0, - "Unit": "pts/h" - } - ] - } - ], - "Parameters": [ - { - "Path": "Applications|Gurley 2006 - Midazolam - po 8 mg (Control)|Oral solution|Application_1|ProtocolSchemaItem|Volume of water/body weight", - "Value": 3.5, - "Unit": "ml/kg" + } + ], + "Parameters": [ + { + "Path": "Applications|Gurley 2006 - Midazolam - po 8 mg (Control)|Oral solution|Application_1|ProtocolSchemaItem|Volume of water/body weight", + "Value": 3.5, + "Unit": "ml/kg" }, { "Path": "Neighborhoods|Caecum_int_Caecum_cell|Midazolam|P (interstitial->intracellular)", @@ -7359,7 +7317,8 @@ "MoleculeName": "UGT1A4" }, { - "Name": "Glomerular Filtration-Optimized" + "Name": "Glomerular Filtration-Optimized", + "SystemicProcessType": "GFR" }, { "Name": "GABRG2-Buhr 1997", @@ -7475,7 +7434,7 @@ }, { "Name": "End time", - "Value": 148.0, + "Value": 180.0, "Unit": "h", "ValueOrigin": { "Source": "Unknown" @@ -7490,31 +7449,6 @@ } } ] - }, - { - "Parameters": [ - { - "Name": "Start time", - "Value": 148.0, - "Unit": "h", - "ValueOrigin": { - "Source": "Unknown" - } - }, - { - "Name": "End time", - "Value": 180.0, - "Unit": "h", - "ValueOrigin": { - "Source": "Unknown" - } - }, - { - "Name": "Resolution", - "Value": 4.0, - "Unit": "pts/h" - } - ] } ], "Parameters": [ @@ -7810,7 +7744,8 @@ "MoleculeName": "CYP3A4" }, { - "Name": "Renal Clearances-fitted" + "Name": "Renal Clearances-fitted", + "SystemicProcessType": "Renal" } ], "Protocol": { @@ -7857,7 +7792,8 @@ "MoleculeName": "UGT1A4" }, { - "Name": "Glomerular Filtration-Optimized" + "Name": "Glomerular Filtration-Optimized", + "SystemicProcessType": "GFR" }, { "Name": "GABRG2-Buhr 1997", @@ -7973,25 +7909,6 @@ "Value": 0.0, "Unit": "h" }, - { - "Name": "End time", - "Value": 2.0, - "Unit": "h" - }, - { - "Name": "Resolution", - "Value": 20.0, - "Unit": "pts/h" - } - ] - }, - { - "Parameters": [ - { - "Name": "Start time", - "Value": 2.0, - "Unit": "h" - }, { "Name": "End time", "Value": 146.0, @@ -8019,7 +7936,7 @@ }, { "Name": "End time", - "Value": 148.0, + "Value": 180.0, "Unit": "h", "ValueOrigin": { "Source": "Unknown" @@ -8034,31 +7951,6 @@ } } ] - }, - { - "Parameters": [ - { - "Name": "Start time", - "Value": 148.0, - "Unit": "h", - "ValueOrigin": { - "Source": "Unknown" - } - }, - { - "Name": "End time", - "Value": 180.0, - "Unit": "h", - "ValueOrigin": { - "Source": "Unknown" - } - }, - { - "Name": "Resolution", - "Value": 4.0, - "Unit": "pts/h" - } - ] } ], "Parameters": [ @@ -8354,7 +8246,8 @@ "MoleculeName": "CYP3A4" }, { - "Name": "Renal Clearances-fitted" + "Name": "Renal Clearances-fitted", + "SystemicProcessType": "Renal" } ], "Protocol": { @@ -8401,7 +8294,8 @@ "MoleculeName": "UGT1A4" }, { - "Name": "Glomerular Filtration-Optimized" + "Name": "Glomerular Filtration-Optimized", + "SystemicProcessType": "GFR" }, { "Name": "GABRG2-Buhr 1997", @@ -8517,25 +8411,6 @@ "Value": 0.0, "Unit": "h" }, - { - "Name": "End time", - "Value": 2.0, - "Unit": "h" - }, - { - "Name": "Resolution", - "Value": 20.0, - "Unit": "pts/h" - } - ] - }, - { - "Parameters": [ - { - "Name": "Start time", - "Value": 2.0, - "Unit": "h" - }, { "Name": "End time", "Value": 24.0, @@ -8543,7 +8418,7 @@ }, { "Name": "Resolution", - "Value": 4.0, + "Value": 20.0, "Unit": "pts/h" } ] @@ -8771,7 +8646,8 @@ "MoleculeName": "UGT1A4" }, { - "Name": "Glomerular Filtration-Optimized" + "Name": "Glomerular Filtration-Optimized", + "SystemicProcessType": "GFR" }, { "Name": "GABRG2-Buhr 1997", @@ -8859,7 +8735,7 @@ }, { "Name": "End time", - "Value": 2.0, + "Value": 48.0, "Unit": "h" }, { @@ -8868,28 +8744,6 @@ "Unit": "pts/h" } ] - }, - { - "Parameters": [ - { - "Name": "Start time", - "Value": 2.0, - "Unit": "h" - }, - { - "Name": "End time", - "Value": 48.0, - "Unit": "h", - "ValueOrigin": { - "Source": "Unknown" - } - }, - { - "Name": "Resolution", - "Value": 4.0, - "Unit": "pts/h" - } - ] } ], "Parameters": [ @@ -9114,7 +8968,8 @@ "MoleculeName": "UGT1A4" }, { - "Name": "Glomerular Filtration-Optimized" + "Name": "Glomerular Filtration-Optimized", + "SystemicProcessType": "GFR" }, { "Name": "GABRG2-Buhr 1997", @@ -9200,32 +9055,10 @@ "Value": 0.0, "Unit": "h" }, - { - "Name": "End time", - "Value": 2.0, - "Unit": "h" - }, - { - "Name": "Resolution", - "Value": 20.0, - "Unit": "pts/h" - } - ] - }, - { - "Parameters": [ - { - "Name": "Start time", - "Value": 2.0, - "Unit": "h" - }, { "Name": "End time", "Value": 72.0, - "Unit": "h", - "ValueOrigin": { - "Source": "Unknown" - } + "Unit": "h" }, { "Name": "Resolution", @@ -9239,14 +9072,11 @@ { "Name": "Start time", "Value": 72.0, - "Unit": "h", - "ValueOrigin": { - "Source": "Unknown" - } + "Unit": "h" }, { "Name": "End time", - "Value": 74.0, + "Value": 120.0, "Unit": "h", "ValueOrigin": { "Source": "Unknown" @@ -9261,31 +9091,6 @@ } } ] - }, - { - "Parameters": [ - { - "Name": "Start time", - "Value": 74.0, - "Unit": "h", - "ValueOrigin": { - "Source": "Unknown" - } - }, - { - "Name": "End time", - "Value": 120.0, - "Unit": "h", - "ValueOrigin": { - "Source": "Unknown" - } - }, - { - "Name": "Resolution", - "Value": 4.0, - "Unit": "pts/h" - } - ] } ], "Parameters": [ @@ -9561,7 +9366,8 @@ "MoleculeName": "CYP3A4" }, { - "Name": "Renal Clearances-fitted" + "Name": "Renal Clearances-fitted", + "SystemicProcessType": "Renal" } ], "Protocol": { @@ -9608,7 +9414,8 @@ "MoleculeName": "UGT1A4" }, { - "Name": "Glomerular Filtration-Optimized" + "Name": "Glomerular Filtration-Optimized", + "SystemicProcessType": "GFR" }, { "Name": "GABRG2-Buhr 1997", @@ -9714,12 +9521,12 @@ }, { "Name": "End time", - "Value": 2.0, + "Value": 72.0, "Unit": "h" }, { "Name": "Resolution", - "Value": 20.0, + "Value": 4.0, "Unit": "pts/h" } ] @@ -9728,7 +9535,7 @@ "Parameters": [ { "Name": "Start time", - "Value": 2.0, + "Value": 72.0, "Unit": "h" }, { @@ -9738,8 +9545,11 @@ }, { "Name": "Resolution", - "Value": 4.0, - "Unit": "pts/h" + "Value": 20.0, + "Unit": "pts/h", + "ValueOrigin": { + "Source": "Unknown" + } } ] } @@ -9997,7 +9807,8 @@ "MoleculeName": "CYP3A4" }, { - "Name": "Renal Clearances-fitted" + "Name": "Renal Clearances-fitted", + "SystemicProcessType": "Renal" } ], "Protocol": { @@ -10044,7 +9855,8 @@ "MoleculeName": "UGT1A4" }, { - "Name": "Glomerular Filtration-Optimized" + "Name": "Glomerular Filtration-Optimized", + "SystemicProcessType": "GFR" }, { "Name": "GABRG2-Buhr 1997", @@ -10145,12 +9957,12 @@ }, { "Name": "End time", - "Value": 2.0, + "Value": 156.0, "Unit": "h" }, { "Name": "Resolution", - "Value": 20.0, + "Value": 4.0, "Unit": "pts/h" } ] @@ -10159,18 +9971,21 @@ "Parameters": [ { "Name": "Start time", - "Value": 2.0, + "Value": 156.0, "Unit": "h" }, { "Name": "End time", - "Value": 324.0, + "Value": 180.0, "Unit": "h" }, { "Name": "Resolution", - "Value": 4.0, - "Unit": "pts/h" + "Value": 20.0, + "Unit": "pts/h", + "ValueOrigin": { + "Source": "Unknown" + } } ] }, @@ -10178,7 +9993,7 @@ "Parameters": [ { "Name": "Start time", - "Value": 324.0, + "Value": 180.0, "Unit": "h", "ValueOrigin": { "Source": "Unknown" @@ -10186,7 +10001,7 @@ }, { "Name": "End time", - "Value": 326.0, + "Value": 324.0, "Unit": "h", "ValueOrigin": { "Source": "Unknown" @@ -10194,7 +10009,7 @@ }, { "Name": "Resolution", - "Value": 20.0, + "Value": 4.0, "Unit": "pts/h", "ValueOrigin": { "Source": "Unknown" @@ -10206,7 +10021,7 @@ "Parameters": [ { "Name": "Start time", - "Value": 326.0, + "Value": 324.0, "Unit": "h", "ValueOrigin": { "Source": "Unknown" @@ -10222,8 +10037,11 @@ }, { "Name": "Resolution", - "Value": 4.0, - "Unit": "pts/h" + "Value": 20.0, + "Unit": "pts/h", + "ValueOrigin": { + "Source": "Unknown" + } } ] } @@ -10522,7 +10340,8 @@ "MoleculeName": "CYP3A4" }, { - "Name": "Renal Clearances-fitted" + "Name": "Renal Clearances-fitted", + "SystemicProcessType": "Renal" } ], "Protocol": { @@ -10569,7 +10388,8 @@ "MoleculeName": "UGT1A4" }, { - "Name": "Glomerular Filtration-Optimized" + "Name": "Glomerular Filtration-Optimized", + "SystemicProcessType": "GFR" }, { "Name": "GABRG2-Buhr 1997", @@ -10624,7 +10444,8 @@ "MoleculeName": "OATP1B1" }, { - "Name": "Glomerular Filtration-GFR" + "Name": "Glomerular Filtration-GFR", + "SystemicProcessType": "GFR" } ], "Protocol": { @@ -10766,25 +10587,6 @@ "Value": 0.0, "Unit": "h" }, - { - "Name": "End time", - "Value": 2.0, - "Unit": "h" - }, - { - "Name": "Resolution", - "Value": 20.0, - "Unit": "pts/h" - } - ] - }, - { - "Parameters": [ - { - "Name": "Start time", - "Value": 2.0, - "Unit": "h" - }, { "Name": "End time", "Value": 24.0, @@ -10792,7 +10594,7 @@ }, { "Name": "Resolution", - "Value": 4.0, + "Value": 20.0, "Unit": "pts/h" } ] @@ -11020,7 +10822,8 @@ "MoleculeName": "UGT1A4" }, { - "Name": "Glomerular Filtration-Optimized" + "Name": "Glomerular Filtration-Optimized", + "SystemicProcessType": "GFR" }, { "Name": "GABRG2-Buhr 1997", @@ -11148,7 +10951,7 @@ }, { "Name": "End time", - "Value": 148.0, + "Value": 170.0, "Unit": "h", "ValueOrigin": { "Source": "Unknown" @@ -11163,31 +10966,6 @@ } } ] - }, - { - "Parameters": [ - { - "Name": "Start time", - "Value": 146.0, - "Unit": "h", - "ValueOrigin": { - "Source": "Unknown" - } - }, - { - "Name": "End time", - "Value": 158.0, - "Unit": "h", - "ValueOrigin": { - "Source": "Unknown" - } - }, - { - "Name": "Resolution", - "Value": 4.0, - "Unit": "pts/h" - } - ] } ], "Parameters": [ @@ -11483,7 +11261,8 @@ "MoleculeName": "CYP3A4" }, { - "Name": "Renal Clearances-fitted" + "Name": "Renal Clearances-fitted", + "SystemicProcessType": "Renal" } ], "Protocol": { @@ -11530,7 +11309,8 @@ "MoleculeName": "UGT1A4" }, { - "Name": "Glomerular Filtration-Optimized" + "Name": "Glomerular Filtration-Optimized", + "SystemicProcessType": "GFR" }, { "Name": "GABRG2-Buhr 1997", @@ -11678,7 +11458,7 @@ }, { "Name": "End time", - "Value": 148.0, + "Value": 170.0, "Unit": "h", "ValueOrigin": { "Source": "Unknown" @@ -11693,31 +11473,6 @@ } } ] - }, - { - "Parameters": [ - { - "Name": "Start time", - "Value": 148.0, - "Unit": "h", - "ValueOrigin": { - "Source": "Unknown" - } - }, - { - "Name": "End time", - "Value": 156.0, - "Unit": "h", - "ValueOrigin": { - "Source": "Unknown" - } - }, - { - "Name": "Resolution", - "Value": 4.0, - "Unit": "pts/h" - } - ] } ], "Parameters": [ @@ -12013,7 +11768,8 @@ "MoleculeName": "CYP3A4" }, { - "Name": "Renal Clearances-fitted" + "Name": "Renal Clearances-fitted", + "SystemicProcessType": "Renal" } ], "Protocol": { @@ -12060,7 +11816,8 @@ "MoleculeName": "UGT1A4" }, { - "Name": "Glomerular Filtration-Optimized" + "Name": "Glomerular Filtration-Optimized", + "SystemicProcessType": "GFR" }, { "Name": "GABRG2-Buhr 1997", @@ -12185,7 +11942,7 @@ }, { "Name": "End time", - "Value": 2.0, + "Value": 24.0, "Unit": "h" }, { @@ -12194,28 +11951,6 @@ "Unit": "pts/h" } ] - }, - { - "Parameters": [ - { - "Name": "Start time", - "Value": 2.0, - "Unit": "h" - }, - { - "Name": "End time", - "Value": 12.0, - "Unit": "h", - "ValueOrigin": { - "Source": "Unknown" - } - }, - { - "Name": "Resolution", - "Value": 4.0, - "Unit": "pts/h" - } - ] } ], "Parameters": [ @@ -12440,7 +12175,8 @@ "MoleculeName": "UGT1A4" }, { - "Name": "Glomerular Filtration-Optimized" + "Name": "Glomerular Filtration-Optimized", + "SystemicProcessType": "GFR" }, { "Name": "GABRG2-Buhr 1997", @@ -12522,7 +12258,7 @@ }, { "Name": "End time", - "Value": 2.0, + "Value": 24.0, "Unit": "h" }, { @@ -12531,28 +12267,6 @@ "Unit": "pts/h" } ] - }, - { - "Parameters": [ - { - "Name": "Start time", - "Value": 2.0, - "Unit": "h" - }, - { - "Name": "End time", - "Value": 10.0, - "Unit": "h", - "ValueOrigin": { - "Source": "Unknown" - } - }, - { - "Name": "Resolution", - "Value": 4.0, - "Unit": "pts/h" - } - ] } ], "Parameters": [ @@ -12777,7 +12491,8 @@ "MoleculeName": "UGT1A4" }, { - "Name": "Glomerular Filtration-Optimized" + "Name": "Glomerular Filtration-Optimized", + "SystemicProcessType": "GFR" }, { "Name": "GABRG2-Buhr 1997", @@ -13323,22 +13038,22 @@ "LLOQ": 1E-09 }, "Values": [ - 16.40435, - 34.99131, - 50.34536, - 32.94821, - 23.61517, - 19.50017, - 15.94042, - 13.84428, - 11.31718, - 9.34903, - 6.316024, - 4.310359, - 3.001572 + 0.01640435, + 0.03499131, + 0.05034536, + 0.03294821, + 0.02361517, + 0.01950017, + 0.01594042, + 0.0138442805, + 0.0113171805, + 0.00934902951, + 0.006316024, + 0.00431035925, + 0.00300157187 ], "Dimension": "Concentration (mass)", - "Unit": "ng/ml" + "Unit": "mg/l" } ], "BaseGrid": {