Source of inhibition constant for CYP3A4 not clear

[AndreDlm]

I have some difficulties understanding where the K_i of fluvoxamine for CYP3A4 comes from. In the PK-Sim file (and this publication here) the following sources are given for this value:

• Yao et al. 2001
• Olesen et al. 2000

Yao et al. report a f_u in liver microsomes of, on average, 0.33 but no K_i for CYP3A4.
Olesen et al. report a K_i of 24 ± 1.8 µM (SEM).
In PK-Sim there is a K_i,u 1.6 µM which would correspond to a f_u,mic of 0.067.