Modeling of published clinical itraconazole-pioglitazone-DDI studies for model evaluation
Within this repository, we distribute a PK-Sim project file containing simulations of all published clinical studies used to evaluate the predictive performance of our models regarding the itraconazole-pioglitazone-DDI, including the respective observed data digitized from literature reports. The applied itraconazole model has been published previously. For further details and documentation please refer to [1].
PK-Sim Version 7.3.0
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The model code is distributed under the GPLv2 License.
[1] Türk D, Hanke N, Wolf S, Frechen S, Eissing T, Wendl T, Schwab M, Lehr T. Physiologically Based Pharmacokinetic Models for Prediction of Complex CYP2C8 and OATP1B1 (SLCO1B1) Drug–Drug–Gene Interactions: A Modeling Network of Gemfibrozil, Repaglinide, Pioglitazone, Rifampicin, Clarithromycin and Itraconazole. Clinical Pharmacokinetics 2019, https://link.springer.com/article/10.1007/s40262-019-00777-x