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Aciclovir Mean Model Report

Table of Contents

1 Sensitivity Analysis

1.1 Sensitivity Analysis for Aciclovir

Figure 1-1: Most sensitive parameters for AUC_tEnd of Aciclovir Plasma.



Figure 1-2: Most sensitive parameters for Total body clearance/F of Aciclovir Plasma.



Figure 1-3: Most sensitive parameters for Vss (plasma)/F of Aciclovir Plasma.



Figure 1-4: Most sensitive parameters for C_max of Aciclovir Plasma.



2 PK parameters

2.1 PK parameters for Aciclovir

Table 2-1: PK parameters for Aciclovir

Path Parameter Value Unit
Aciclovir Plasma AUC_tEnd 4064.12 µmol*min/l
Aciclovir Plasma Total body clearance/F 4.02 ml/min/kg
Aciclovir Plasma Vss (plasma)/F 777.83 ml/kg
Aciclovir Plasma C_max 50.25 µmol/l


3 Time profiles and residual plots

3.1 Time profiles and residual plots for Aciclovir

Figure 3-1: Time profiles for Aciclovir. Time profiles are plotted in a linear scale.



Figure 3-2: Time profiles for Aciclovir. Time profiles are plotted in a logarithmic scale.