From 91fcfb83bc5566fe0031d111c9e34d67b8993b51 Mon Sep 17 00:00:00 2001 From: Juri Solodenko Date: Tue, 5 Nov 2024 14:59:54 +0100 Subject: [PATCH] Update README.md --- README.md | 17 ++++++++++++----- 1 file changed, 12 insertions(+), 5 deletions(-) diff --git a/README.md b/README.md index f3a5abd..c8422f8 100644 --- a/README.md +++ b/README.md @@ -1,8 +1,15 @@ -# COMPOUND-Model -**_tbd._** +# Valproic acid-Model +Whole-body PBPK model of valproic acid including non-linear binding with albumin in adults, children and children with hypoalbuminemia. +This repository contains: +- a PK-Sim snapshot (*.json ) file of the current PBPK model +- static content (*.md files) as inputs for an evaluation plan +- an evaluation plan (evaluation-plan.json) to create an evaluation report using the snapshot and static text blocks to display the performance of the model +This PBPK model is intended to be used as a basis for the implementation of non-linear protein binding using PBPK/Mobi. The PBPK model helped assess the nonlinear dose-exposure relationship of VPA and the impact of albumin concentrations on the achievement of target exposure. +This whole-body PBPK model of valproic acid has been developed using in published information and the parameters were optimized based on pharmacokinetic clinical data. -## Repository files -**_tbd._** +The model has then been evaluated simulating a large number of clinical studies and comparing with respective observed data, obtained from published clinical pharmacokinetic studies. + +This model has been published[1](#references). ## Code of conduct Everyone interacting in the Open Systems Pharmacology community (codebases, issue trackers, chat rooms, mailing lists etc...) is expected to follow the Open Systems Pharmacology [code of conduct](https://github.com/Open-Systems-Pharmacology/Suite/blob/master/CODE_OF_CONDUCT.md#contributor-covenant-code-of-conduct). @@ -14,4 +21,4 @@ We encourage contribution to the Open Systems Pharmacology community. Before get The model code is distributed under the [GPLv2 License](https://github.com/Open-Systems-Pharmacology/Suite/blob/develop/LICENSE). ## References -[1] **_tbd._** +[1] Karatza, E., Sinha, J., Maglalang, P. D., Edginton, A., & Gonzalez, D. (2024). Physiologically-Based Pharmacokinetic Modeling of Total and Unbound Valproic Acid to Evaluate Dosing in Children With and Without Hypoalbuminemia. Clinical pharmacokinetics, 63(10), 1435–1448. [https://doi.org/10.1007/s40262-024-01418-8](https://doi.org/10.1007/s40262-024-01418-8)