diff --git a/doc/source/changelog.rst b/doc/source/changelog.rst
index 121f9815d..cca6b650e 100644
--- a/doc/source/changelog.rst
+++ b/doc/source/changelog.rst
@@ -58,6 +58,7 @@ organisation on `GitHub <https://github.com/openbiosim/sire>`__.
   of pinned dependencies for :mod:`sire`. This included fixing the way we
   specify ``blas`` so that we don't force a pin to ``openblas``,
   removing the requirement for ``watchdog`` as it is not used any more,
+  removing ``pypdb`` from the BioSimSpace run requirements,
   and switching to ``qt-main`` rather than the entire ``qt`` package. Our run
   dependencies are now just ``boost``, ``gsl``, ``lazy_import``,
   ``libnetcdf``, ``openmm``, ``pandas``, ``qt-main``, ``rich`` and ``tbb``.
diff --git a/requirements_bss.txt b/requirements_bss.txt
index 23faa5efd..f04cf3943 100644
--- a/requirements_bss.txt
+++ b/requirements_bss.txt
@@ -26,7 +26,6 @@ parmed
 py3dmol
 pydot
 pygtail
-pypdb
 pyyaml
 rdkit