diff --git a/src/petab_gui/controllers/mother_controller.py b/src/petab_gui/controllers/mother_controller.py
index a1c0d2a..0d44aed 100644
--- a/src/petab_gui/controllers/mother_controller.py
+++ b/src/petab_gui/controllers/mother_controller.py
@@ -832,6 +832,7 @@ def new_file(self):
                 continue
             controller.clear_table()
         self.view.plot_dock.plot_it()
+        self.unsaved_changes_change(False)
 
     def check_model(self):
         """Check the consistency of the model. And log the results."""