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both_gene.txt
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Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR
GOTERM_CC_DIRECT GO:0070062~extracellular exosome 26 41.269841269841265 3.123981848619222E-7 CLSTN3, MMP9, MRAS, CSPG4, SRC, GOT1, FAT1, FAM129B, FGL1, MSN, LPL, KIF12, ABCB11, STXBP1, DPYSL2, THY1, C8B, PSMC6, SNED1, H2AFY2, FABP4, APAF1, IGFBP2, HPGD, PON3, PYGB 62 2646 18520 2.935166898300539 4.560910198947443E-5 4.560910198947443E-5 3.713097166069268E-4
UP_KEYWORDS Disulfide bond 20 31.746031746031743 1.2999805464192386E-5 LPL, SCUBE1, MICU2, MMP9, MET, CSPG4, ACKR2, IGF1, PDIA5, GRIA3, CPN1, THY1, C8B, SNED1, FAT1, GALNT18, FGL1, IGFBP2, CD302, PON3 63 2199 20793 3.001797353775525 0.0018961839019954185 0.0018961839019954185 0.015450220260371239
GOTERM_BP_DIRECT GO:0042493~response to drug 10 15.873015873015872 6.249430609611817E-5 LPL, ABCB11, MMP9, GNA12, MET, FABP4, SRD5A1, DPYSL2, IGFBP2, SRC 60 528 17535 5.535037878787878 0.03872777323223531 0.03872777323223531 0.09291526493114821
UP_KEYWORDS Glycoprotein 18 28.57142857142857 1.1122001745440266E-4 LPL, CLSTN3, ABCB11, MMP9, MET, CSPG4, ACKR2, GRIA3, ABCA2, CPN1, THY1, C8B, SNED1, SLC7A2, IGFBP2, CD302, ROS1, PON3 63 2123 20793 2.79833120247628 0.016107883474082763 0.00808663859895642 0.13211393316692188
UP_KEYWORDS Signal 23 36.507936507936506 2.153477224023581E-4 HSD17B11, LPL, CLSTN3, SCUBE1, MMP9, MET, CAR12, CSPG4, IGF1, PDIA5, GRIA3, CPN1, THY1, C8B, SNED1, TMEM154, FAT1, APOF, FGL1, IGFBP2, ROS1, CD302, PON3 63 3420 20793 2.219618490671122 0.03095492709341663 0.010426646136695417 0.2556582741653268
UP_SEQ_FEATURE signal peptide 19 30.158730158730158 5.651260865854328E-4 HSD17B11, LPL, CLSTN3, MMP9, MET, CSPG4, IGF1, PDIA5, GRIA3, CPN1, THY1, C8B, SNED1, APOF, FGL1, IGFBP2, CD302, ROS1, PON3 43 1586 7976 2.22211795067304 0.12439672248164257 0.12439672248164257 0.7245701716004915
UP_KEYWORDS Phosphoprotein 24 38.095238095238095 9.128073451777392E-4 ABCB11, MICU2, MET, CSPG4, STXBP1, HAL, ACKR2, GRIA3, ABCA2, DPYSL2, SRC, SHANK3, GCH1, THY1, C8B, GOT1, SLC7A2, FABP4, FAM129B, MSN, GADD45A, ROS1, PON3, PYGB 63 4047 20793 1.9572875851600833 0.12482440634488834 0.032783271059803165 1.079570712499156
UP_KEYWORDS Secreted 11 17.46031746031746 9.779347669337567E-4 HSD17B11, LPL, C8B, SNED1, APOF, MMP9, IGF1, FGL1, IGFBP2, PON3, CPN1 63 1045 20793 3.4741854636591474 0.1331144653469618 0.02816541311729792 1.1561869732958807
GOTERM_BP_DIRECT GO:0051384~response to glucocorticoid 5 7.936507936507936 0.001042453807258314 GOT1, IGF1, FABP4, IGFBP2, CPN1 60 133 17535 10.986842105263158 0.4827218003189214 0.2807794499035232 1.5394080390380926
UP_KEYWORDS Nucleotide-binding 12 19.047619047619047 0.001716299252735848 KIF12, PSMC6, ABCB11, MRAS, GNA12, MET, ABCA2, APAF1, ARL5B, ROS1, SRC, GCH1 63 1327 20793 2.9846054473032617 0.22181809581568113 0.04093762261917033 2.0210103715557537
GOTERM_MF_DIRECT GO:0005515~protein binding 14 22.22222222222222 0.001967102590433284 ABCB11, MMP9, MRAS, STXBP1, IGF1, GRIA3, DPYSL2, SHANK3, SRC, GCH1, THY1, FABP4, PXMP2, APAF1 57 1589 16650 2.5736146533735216 0.2773943055672866 0.2773943055672866 2.3617483436793374
KEGG_PATHWAY rno05205:Proteoglycans in cancer 6 9.523809523809524 0.0021511524721419826 MMP9, MRAS, MET, IGF1, MSN, SRC 37 201 7780 6.2767244856797095 0.2293876438128747 0.2293876438128747 2.4453555518763936
GOTERM_BP_DIRECT GO:0010226~response to lithium ion 3 4.761904761904762 0.002690737177182117 CSPG4, GRIA3, IGFBP2 60 23 17535 38.119565217391305 0.8178341729920694 0.43312282602919494 3.928417588416644
UP_KEYWORDS Lipoprotein 7 11.11111111111111 0.0030557114900556298 LPL, MRAS, GNA12, GRIA3, FAM129B, SRC, THY1 63 481 20793 4.803187803187803 0.36033897892730427 0.061836450493548356 3.572156309372232
GOTERM_CC_DIRECT GO:0043209~myelin sheath 5 7.936507936507936 0.0036178214403218855 STXBP1, SRD5A1, DPYSL2, MSN, THY1 62 191 18520 7.819625063333896 0.4109002242808584 0.23247164500642614 4.2163982886652125
GOTERM_CC_DIRECT GO:0009986~cell surface 8 12.698412698412698 0.00386543725998143 LPL, CLSTN3, SCUBE1, MET, CSPG4, MSN, ROS1, THY1 62 612 18520 3.9047016656124813 0.4318940784791625 0.17178497424070582 4.498941443097171
GOTERM_BP_DIRECT GO:0050731~positive regulation of peptidyl-tyrosine phosphorylation 4 6.349206349206349 0.004906334816439044 CSPG4, IGF1, SRC, THY1 60 102 17535 11.46078431372549 0.9553292059212501 0.5402667466897961 7.0545695352347675
GOTERM_BP_DIRECT GO:0006694~steroid biosynthetic process 3 4.761904761904762 0.00517369534811098 HSD17B11, HSD17B2, SRD5A1 60 32 17535 27.398437500000004 0.9623063321014228 0.4808968312108487 7.425324506924536
GOTERM_BP_DIRECT GO:0009612~response to mechanical stimulus 4 6.349206349206349 0.005179025435125972 MMP9, IGF1, IGFBP2, SRC 60 104 17535 11.240384615384617 0.9624337523935454 0.42128291646215377 7.432701816108556
KEGG_PATHWAY rno05202:Transcriptional misregulation in cancer 5 7.936507936507936 0.006350929365980457 MMP9, MET, IGF1, GRIA3, HPGD 37 162 7780 6.489823156489824 0.5374094974240133 0.31985993900080656 7.06285035295341
INTERPRO IPR027417:P-loop containing nucleoside triphosphate hydrolase 9 14.285714285714285 0.006743948407653131 KIF12, PSMC6, ABCB11, RASEF, MRAS, GNA12, ABCA2, APAF1, ARL5B 62 895 19384 3.143917823031177 0.7665670024339112 0.7665670024339112 8.223912245175292
GOTERM_CC_DIRECT GO:0014069~postsynaptic density 5 7.936507936507936 0.007829119011544853 CLSTN3, MET, GRIA3, SHANK3, SRC 62 238 18520 6.275413391162917 0.6825863324321656 0.24940372328047666 8.919053644053598
UP_KEYWORDS Calcium 7 11.11111111111111 0.008152213482683673 SNED1, CLSTN3, MMP9, FAT1, SCUBE1, APAF1, PON3 63 590 20793 3.915819209039548 0.6973266701206227 0.13876480487190768 9.270961947319002
GOTERM_BP_DIRECT GO:0032869~cellular response to insulin stimulus 4 6.349206349206349 0.008228107444810312 GOT1, IGF1, SRD5A1, SRC 60 123 17535 9.504065040650406 0.9946017245697644 0.5257182275747255 11.56418574060314
GOTERM_BP_DIRECT GO:0019556~histidine catabolic process to glutamate and formamide 2 3.1746031746031744 0.010060743851824528 AMDHD1, HAL 60 3 17535 194.83333333333331 0.998322735929293 0.5501422772154456 13.963952189921391
GOTERM_BP_DIRECT GO:0007584~response to nutrient 4 6.349206349206349 0.011027702696185854 MMP9, IGF1, APAF1, IGFBP2 60 137 17535 8.532846715328466 0.999095584622096 0.540993685849482 15.20553113055123
UP_SEQ_FEATURE active site:Proton acceptor 7 11.11111111111111 0.012971889228152494 HSD17B11, HSD17B2, MET, HPGD, ROS1, PON3, SRC 43 375 7976 3.4624496124031015 0.9535016452310885 0.7843652282935065 15.461889825527775
UP_KEYWORDS Lipid metabolism 5 7.936507936507936 0.013148291036430618 HSD17B11, LPL, HSD17B2, APOF, HPGD 63 306 20793 5.39293495175848 0.8551971731755879 0.19322393657925863 14.556469913606717
UP_KEYWORDS EGF-like domain 4 6.349206349206349 0.014051335239627436 C8B, SNED1, FAT1, SCUBE1 63 169 20793 7.8117779656241195 0.873314104690508 0.18665869821764935 15.48117427442175
GOTERM_CC_DIRECT GO:0043234~protein complex 7 11.11111111111111 0.015045517002315 CLSTN3, MMP9, STXBP1, PXMP2, GRIA3, DPYSL2, GCH1 62 611 18520 3.4222057969484188 0.8906649172608445 0.3576793156979293 16.488596003824163
INTERPRO IPR002347:Glucose/ribitol dehydrogenase 3 4.761904761904762 0.015336934693484697 HSD17B11, HSD17B2, HPGD 62 60 19384 15.63225806451613 0.9639550616468697 0.8101449543648358 17.79996312596327
GOTERM_BP_DIRECT GO:0006810~transport 4 6.349206349206349 0.015346693337803977 SLC25A32, FABP4, ABCA2, NXT2 60 155 17535 7.541935483870967 0.9999431051167206 0.6237233047354376 20.54983236371546
GOTERM_MF_DIRECT GO:0019901~protein kinase binding 6 9.523809523809524 0.01566674046261371 STXBP1, CSPG4, DPYSL2, MSN, SRC, THY1 57 438 16650 4.0014419610670515 0.9261319986907188 0.7282133165343063 17.44235363886223
GOTERM_BP_DIRECT GO:0048545~response to steroid hormone 3 4.761904761904762 0.017935928334519024 IGF1, ABCA2, IGFBP2 60 61 17535 14.37295081967213 0.999989226221037 0.6464937500517323 23.601327763705093
GOTERM_BP_DIRECT GO:0001558~regulation of cell growth 3 4.761904761904762 0.01905972695471412 CLSTN3, H2AFY2, IGFBP2 60 63 17535 13.916666666666668 0.9999947748213547 0.6370542110180046 24.891432765676434
GOTERM_BP_DIRECT GO:0060348~bone development 3 4.761904761904762 0.01905972695471412 HSD17B2, IGF1, SRD5A1 60 63 17535 13.916666666666668 0.9999947748213547 0.6370542110180046 24.891432765676434
GOTERM_BP_DIRECT GO:0042632~cholesterol homeostasis 3 4.761904761904762 0.019632523577453338 LPL, FABP4, ABCA2 60 64 17535 13.699218750000002 0.9999963877172705 0.6186112961617483 25.54114922809031
GOTERM_CC_DIRECT GO:0016324~apical plasma membrane 5 7.936507936507936 0.01965195044199193 ABCB11, CSPG4, MSN, IGFBP2, THY1 62 313 18520 4.771720086571164 0.9448529592443 0.3830446961606968 21.014420424183943
GOTERM_BP_DIRECT GO:0051450~myoblast proliferation 2 3.1746031746031744 0.020021967722029667 MET, IGF1 60 6 17535 97.41666666666666 0.9999971898652515 0.5986895115616162 25.979893134494624
UP_KEYWORDS Membrane 31 49.2063492063492 0.020343444429583746 HSD17B2, CLSTN3, MRAS, GNA12, CSPG4, ABCA2, SRC, TMEM154, FAT1, PXMP2, SRD5A1, FAM129B, MSN, GALNT18, ROS1, LPL, ABCB11, CAR12, MET, STXBP1, ACKR2, IGF1, GRIA3, DPYSL2, SHANK3, THY1, SLC25A32, SLC7A2, CD302, OPN3, SGCB 63 7278 20793 1.40580876483597 0.9502512751608518 0.23875293340489745 21.67407688366916
INTERPRO IPR013032:EGF-like, conserved site 4 6.349206349206349 0.021717281392280473 C8B, SNED1, FAT1, SCUBE1 62 189 19384 6.616828810377197 0.9910907308275072 0.7926929714110797 24.305114396540763
GOTERM_CC_DIRECT GO:0030175~filopodium 3 4.761904761904762 0.021734405479057643 FAT1, MSN, CD302 62 69 18520 12.987377279102384 0.9595712943021691 0.3676526671255267 22.985738076199404
GOTERM_BP_DIRECT GO:0006702~androgen biosynthetic process 2 3.1746031746031744 0.026607972982487904 HSD17B2, SRD5A1 60 8 17535 73.0625 0.999999960383154 0.6789849996800066 33.04397608030604
GOTERM_BP_DIRECT GO:0032526~response to retinoic acid 3 4.761904761904762 0.027052170167385328 HSD17B2, MMP9, IGFBP2 60 76 17535 11.536184210526317 0.9999999703108378 0.6615166025595727 33.49701784552577
GOTERM_CC_DIRECT GO:0045211~postsynaptic membrane 4 6.349206349206349 0.027179707418443767 CLSTN3, MET, GRIA3, SHANK3 62 197 18520 6.065171115113803 0.9821037228853337 0.39522290162272444 27.92940862339489
GOTERM_CC_DIRECT GO:0005615~extracellular space 10 15.873015873015872 0.027541879824237493 LPL, C8B, MMP9, SCUBE1, MET, IGF1, MSN, IGFBP2, PON3, CPN1 62 1316 18520 2.2698303755270124 0.9830506738566782 0.3643191043445815 28.247674099658738
GOTERM_BP_DIRECT GO:0000187~activation of MAPK activity 3 4.761904761904762 0.028383178797815788 MET, CSPG4, IGF1 60 78 17535 11.240384615384617 0.999999987501561 0.6571460453414144 34.837467411390286
GOTERM_MF_DIRECT GO:0005509~calcium ion binding 7 11.11111111111111 0.028828851672436453 SNED1, CLSTN3, RASEF, FAT1, MICU2, SCUBE1, GCH1 57 696 16650 2.937840290381125 0.9919868669275915 0.7998906175634225 29.888066249705012
GOTERM_MF_DIRECT GO:0004713~protein tyrosine kinase activity 3 4.761904761904762 0.02969988191379759 MET, ROS1, SRC 57 80 16650 10.953947368421053 0.9930895886705376 0.7116791997689322 30.647552785599085
INTERPRO IPR020635:Tyrosine-protein kinase, catalytic domain 3 4.761904761904762 0.03006571936915443 MET, ROS1, SRC 62 86 19384 10.90622655663916 0.9985887744489763 0.8061797685927664 32.101194287596236
SMART SM00219:TyrKc 3 4.761904761904762 0.03070818074598978 MET, ROS1, SRC 32 86 9680 10.552325581395348 0.7691320083026648 0.7691320083026648 25.63946528036808
UP_KEYWORDS Tyrosine-protein kinase 3 4.761904761904762 0.030841527614442196 MET, ROS1, SRC 63 92 20793 10.762422360248445 0.989680935655477 0.3169224269659613 31.088575830965826
UP_KEYWORDS ATP-binding 8 12.698412698412698 0.03289131052369437 KIF12, PSMC6, ABCB11, MET, ABCA2, APAF1, ROS1, SRC 63 1029 20793 2.56596788375214 0.9924248423599723 0.31312725704235234 32.80111067368989
KEGG_PATHWAY rno04730:Long-term depression 3 4.761904761904762 0.03309258344207015 GNA12, IGF1, GRIA3 37 62 7780 10.174367916303401 0.9829559866442457 0.7426501287684888 32.08332611594842
INTERPRO IPR011059:Metal-dependent hydrolase, composite domain 2 3.1746031746031744 0.0340852706700118 AMDHD1, DPYSL2 62 11 19384 56.84457478005865 0.9994221174582464 0.7749039288410713 35.58465000384751
INTERPRO IPR018097:EGF-like calcium-binding, conserved site 3 4.761904761904762 0.03538703914618996 SNED1, FAT1, SCUBE1 62 94 19384 9.978037062457105 0.9995675708284704 0.7250085671413486 36.67701077080703
INTERPRO IPR000152:EGF-type aspartate/asparagine hydroxylation site 3 4.761904761904762 0.03607619211576888 SNED1, FAT1, SCUBE1 62 95 19384 9.873005093378607 0.9996291638979201 0.6764934010433046 37.24837105571649
GOTERM_BP_DIRECT GO:0007567~parturition 2 3.1746031746031744 0.036405475948866464 MMP9, HPGD 60 11 17535 53.13636363636363 0.999999999933746 0.7280357644677299 42.39764469408862
UP_SEQ_FEATURE disulfide bond 13 20.634920634920633 0.03678004007975852 LPL, C8B, SNED1, MMP9, CSPG4, IGF1, PDIA5, FGL1, IGFBP2, CD302, PON3, CPN1, THY1 43 1327 7976 1.817143057429768 0.9998502088101598 0.946891737868562 38.24992167003599
INTERPRO IPR006680:Amidohydrolase 1 2 3.1746031746031744 0.037126658089935115 AMDHD1, DPYSL2 62 12 19384 52.10752688172043 0.9997066608386266 0.6382394079530178 38.110156829784216
INTERPRO IPR008266:Tyrosine-protein kinase, active site 3 4.761904761904762 0.03747006282525551 MET, ROS1, SRC 62 97 19384 9.669437978051214 0.9997283167236526 0.5984082639456121 38.38950742991065
GOTERM_MF_DIRECT GO:0005525~GTP binding 5 7.936507936507936 0.03873647676341477 RASEF, MRAS, GNA12, ARL5B, GCH1 57 380 16650 3.843490304709141 0.9985242719670812 0.7284803498174912 38.09350316093296
GOTERM_BP_DIRECT GO:0071394~cellular response to testosterone stimulus 2 3.1746031746031744 0.03964971681532351 SRD5A1, MSN 60 12 17535 48.70833333333333 0.9999999999921377 0.7396513690665392 45.215889659529395
GOTERM_BP_DIRECT GO:0048771~tissue remodeling 2 3.1746031746031744 0.03964971681532351 MMP9, CSPG4 60 12 17535 48.70833333333333 0.9999999999921377 0.7396513690665392 45.215889659529395
UP_KEYWORDS GTP-binding 4 6.349206349206349 0.04021284728452847 MRAS, GNA12, ARL5B, GCH1 63 254 20793 5.197600299962504 0.997502300856642 0.3482065243660978 38.60475364251966
KEGG_PATHWAY rno04115:p53 signaling pathway 3 4.761904761904762 0.041304492036504444 IGF1, APAF1, GADD45A 37 70 7780 9.011583011583012 0.9939275522387991 0.720847869431227 38.42692646906352
GOTERM_CC_DIRECT GO:0005925~focal adhesion 5 7.936507936507936 0.04141121058973439 FAT1, GNA12, CSPG4, MSN, THY1 62 396 18520 3.7715868361029647 0.9979187585519973 0.46069773207274467 39.50970989045276
GOTERM_MF_DIRECT GO:0004303~estradiol 17-beta-dehydrogenase activity 2 3.1746031746031744 0.04286730109678332 HSD17B11, HSD17B2 57 13 16650 44.939271255060724 0.9992748876192196 0.7002672349647329 41.24649119081325
GOTERM_BP_DIRECT GO:0008283~cell proliferation 4 6.349206349206349 0.043252760709726175 CSPG4, IGF1, ROS1, SRC 60 232 17535 5.038793103448276 0.9999999999992691 0.7527182415352758 48.19482573724838
GOTERM_BP_DIRECT GO:0006469~negative regulation of protein kinase activity 3 4.761904761904762 0.044648226845759996 FABP4, GADD45A, THY1 60 100 17535 8.7675 0.9999999999997095 0.7470642529640874 49.3074310671738
UP_KEYWORDS Transport 9 14.285714285714285 0.046241392137774624 SLC25A32, ABCB11, SLC7A2, APOF, STXBP1, FABP4, GRIA3, ABCA2, NXT2 63 1349 20793 2.2019485333050937 0.9990045562962971 0.3692347194723027 43.034790497620946
GOTERM_CC_DIRECT GO:0005622~intracellular 8 12.698412698412698 0.048697757749915166 RASEF, MRAS, GNA12, CSPG4, IGF1, RCAN3, ARL5B, SHANK3 62 1016 18520 2.3520447040894084 0.9993168690255193 0.48450122887960345 44.75433685730511
GOTERM_BP_DIRECT GO:0016337~single organismal cell-cell adhesion 3 4.761904761904762 0.04872950938071092 FAT1, SRC, THY1 60 105 17535 8.35 0.9999999999999806 0.7619140319247778 52.434860107501436
GOTERM_BP_DIRECT GO:0071803~positive regulation of podosome assembly 2 3.1746031746031744 0.04931814965927453 MSN, SRC 60 15 17535 38.96666666666667 0.9999999999999869 0.7508587883696218 52.87077960663487
GOTERM_BP_DIRECT GO:0010447~response to acidic pH 2 3.1746031746031744 0.04931814965927453 MET, SRC 60 15 17535 38.96666666666667 0.9999999999999869 0.7508587883696218 52.87077960663487
GOTERM_BP_DIRECT GO:0055013~cardiac muscle cell development 2 3.1746031746031744 0.04931814965927453 MET, SGCB 60 15 17535 38.96666666666667 0.9999999999999869 0.7508587883696218 52.87077960663487
UP_KEYWORDS Cytoplasm 13 20.634920634920633 0.050434289037884925 GOT1, STXBP1, FABP4, DPYSL2, FAM129B, MSN, APAF1, HPGD, CD302, SRC, SHANK3, GCH1, NXT2 63 2410 20793 1.780339853783837 0.9994768171874046 0.3763860210748281 45.94114463366283
GOTERM_BP_DIRECT GO:0032006~regulation of TOR signaling 2 3.1746031746031744 0.05251964675726626 GNA12, ROS1 60 16 17535 36.53125 0.9999999999999984 0.7584452306933289 55.17713161986999
GOTERM_BP_DIRECT GO:0007565~female pregnancy 3 4.761904761904762 0.05379887194012836 IGF1, IGFBP2, HPGD 60 111 17535 7.898648648648649 0.9999999999999993 0.7529061671079149 56.06889211182493
GOTERM_BP_DIRECT GO:0043627~response to estrogen 3 4.761904761904762 0.05379887194012836 ABCB11, SRD5A1, IGFBP2 60 111 17535 7.898648648648649 0.9999999999999993 0.7529061671079149 56.06889211182493
GOTERM_BP_DIRECT GO:1900745~positive regulation of p38MAPK cascade 2 3.1746031746031744 0.05571054468735186 MET, GADD45A 60 17 17535 34.38235294117647 0.9999999999999998 0.7517647776977551 57.3707405032384
GOTERM_BP_DIRECT GO:0060292~long term synaptic depression 2 3.1746031746031744 0.05571054468735186 STXBP1, SHANK3 60 17 17535 34.38235294117647 0.9999999999999998 0.7517647776977551 57.3707405032384
INTERPRO IPR001881:EGF-like calcium-binding 3 4.761904761904762 0.055710639916815116 SNED1, FAT1, SCUBE1 62 121 19384 7.7515329245534526 0.9999955578247185 0.7084187663277857 51.66345060668218
SMART SM00179:EGF_CA 3 4.761904761904762 0.056946476157104624 SNED1, FAT1, SCUBE1 32 121 9680 7.5 0.9364364588784871 0.7478818905324077 42.701805158078734
GOTERM_CC_DIRECT GO:0043195~terminal bouton 3 4.761904761904762 0.05948848481227895 STXBP1, GRIA3, DPYSL2 62 120 18520 7.467741935483871 0.9998708301622502 0.5258343459950856 51.75957472527833
GOTERM_CC_DIRECT GO:0048471~perinuclear region of cytoplasm 6 9.523809523809524 0.059921660809036534 FAT1, SRD5A1, MSN, ROS1, SRC, NXT2 62 642 18520 2.7916792282182694 0.9998792323218639 0.500412465397321 52.022996405462365
UP_KEYWORDS Alternative splicing 7 11.11111111111111 0.060133932959513574 SLC7A2, STXBP1, IGF1, GRIA3, ROS1, SHANK3, SRC 63 938 20793 2.463041933191187 0.9998831492149135 0.41293767015765703 52.15160113991827
INTERPRO IPR009030:Insulin-like growth factor binding protein, N-terminal 3 4.761904761904762 0.061514669391735964 SNED1, SCUBE1, IGFBP2 62 128 19384 7.327620967741935 0.9999988199238145 0.7108769401496159 55.29897815884739
GOTERM_BP_DIRECT GO:0014070~response to organic cyclic compound 4 6.349206349206349 0.06364492586774721 MMP9, MET, IGF1, SRD5A1 60 272 17535 4.297794117647059 1.0 0.7854652016236766 62.398942804075496
GOTERM_BP_DIRECT GO:0060992~response to fungicide 2 3.1746031746031744 0.06521998779279839 GRIA3, SRD5A1 60 20 17535 29.224999999999998 1.0 0.7817924811396302 63.328832048779546
GOTERM_MF_DIRECT GO:0042802~identical protein binding 6 9.523809523809524 0.06576570296866033 GOT1, MMP9, SCUBE1, STXBP1, APAF1, SHANK3 57 647 16650 2.708858700073212 0.9999866583936909 0.7988124230398359 56.209190751188856
GOTERM_BP_DIRECT GO:0032496~response to lipopolysaccharide 4 6.349206349206349 0.06817626748645923 MMP9, IGF1, HPGD, GCH1 60 280 17535 4.175000000000001 1.0 0.7853713878455038 65.0165220101211
GOTERM_MF_DIRECT GO:0030742~GTP-dependent protein binding 2 3.1746031746031744 0.06834459972360138 MRAS, GCH1 57 21 16650 27.81954887218045 0.9999915447698214 0.7677847809471587 57.654145815727496
INTERPRO IPR001245:Serine-threonine/tyrosine-protein kinase catalytic domain 3 4.761904761904762 0.06838887368578667 MET, ROS1, SRC 62 136 19384 6.896584440227703 0.999999757085554 0.7189472891467951 59.27836918126316
INTERPRO IPR003593:AAA+ ATPase domain 3 4.761904761904762 0.07102978331815726 PSMC6, ABCB11, ABCA2 62 139 19384 6.747737294035739 0.9999998680574252 0.704335731399072 60.71837276007288
GOTERM_BP_DIRECT GO:0032148~activation of protein kinase B activity 2 3.1746031746031744 0.07150725002505783 IGF1, SRC 60 22 17535 26.568181818181817 1.0 0.7904919295173437 66.83119598409041
SMART SM00382:AAA 3 4.761904761904762 0.07263227952903216 PSMC6, ABCB11, ABCA2 32 139 9680 6.528776978417266 0.9711036608000388 0.6931348220798059 51.14010583061106
GOTERM_CC_DIRECT GO:0005829~cytosol 10 15.873015873015872 0.07508150218640217 GOT1, STXBP1, HAL, FABP4, APAF1, DPYSL2, FAM129B, SRC, GCH1, THY1 62 1590 18520 1.8786772164739296 0.9999887512072955 0.5568940668307216 60.45310023044899
KEGG_PATHWAY rno04015:Rap1 signaling pathway 4 6.349206349206349 0.0771544828389399 MRAS, MET, IGF1, SRC 37 216 7780 3.8938938938938943 0.9999396593704 0.856740982791808 60.2714008171819
KEGG_PATHWAY rno04810:Regulation of actin cytoskeleton 4 6.349206349206349 0.07883832784474173 MRAS, GNA12, MSN, SRC 37 218 7780 3.858170096702207 0.9999516229929593 0.8091144005951099 61.09684902616112
GOTERM_BP_DIRECT GO:0042104~positive regulation of activated T cell proliferation 2 3.1746031746031744 0.08086027350534598 IGF1, IGFBP2 60 25 17535 23.38 1.0 0.8207513648075497 71.46827259329345
GOTERM_BP_DIRECT GO:0019433~triglyceride catabolic process 2 3.1746031746031744 0.08086027350534598 LPL, FABP4 60 25 17535 23.38 1.0 0.8207513648075497 71.46827259329345
GOTERM_BP_DIRECT GO:0007420~brain development 4 6.349206349206349 0.08199646532419252 MET, H2AFY2, APAF1, DPYSL2 60 303 17535 3.858085808580858 1.0 0.8154236813299949 71.98840350322118
UP_SEQ_FEATURE domain:ABC transporter 2 2 3.1746031746031744 0.08592757209280914 ABCB11, ABCA2 43 17 7976 21.822161422708618 0.9999999993232268 0.9948995231212672 68.51977523682066
UP_SEQ_FEATURE domain:ABC transporter 1 2 3.1746031746031744 0.08592757209280914 ABCB11, ABCA2 43 17 7976 21.822161422708618 0.9999999993232268 0.9948995231212672 68.51977523682066
GOTERM_BP_DIRECT GO:0033344~cholesterol efflux 2 3.1746031746031744 0.08704410268518609 APOF, ABCA2 60 27 17535 21.64814814814815 1.0 0.8251950552638456 74.1940015895153
GOTERM_BP_DIRECT GO:0007568~aging 4 6.349206349206349 0.08965448067437007 MMP9, IGF1, APAF1, IGFBP2 60 315 17535 3.7111111111111112 1.0 0.8255317747422714 75.27000896341708
GOTERM_BP_DIRECT GO:2001243~negative regulation of intrinsic apoptotic signaling pathway 2 3.1746031746031744 0.09012066185096775 MMP9, SRC 60 28 17535 20.875 1.0 0.8182959229969659 75.45770934905988
UP_SEQ_FEATURE nucleotide phosphate-binding region:ATP 2 2 3.1746031746031744 0.09075117329716284 ABCB11, ABCA2 43 18 7976 20.60981912144703 0.9999999998048151 0.9885688685811209 70.59120898247622
UP_SEQ_FEATURE nucleotide phosphate-binding region:ATP 1 2 3.1746031746031744 0.09075117329716284 ABCB11, ABCA2 43 18 7976 20.60981912144703 0.9999999998048151 0.9885688685811209 70.59120898247622
UP_KEYWORDS Steroid biosynthesis 2 3.1746031746031744 0.09120040658685523 HSD17B11, HSD17B2 63 32 20793 20.62797619047619 0.9999991363334214 0.5396052743268372 67.91069742369852
INTERPRO IPR005225:Small GTP-binding protein domain 3 4.761904761904762 0.0923157506287897 RASEF, MRAS, ARL5B 62 162 19384 5.789725209080047 0.9999999990963883 0.7740570966876001 70.72364645446105
GOTERM_BP_DIRECT GO:0043066~negative regulation of apoptotic process 5 7.936507936507936 0.09593006468491448 MMP9, IGF1, FAM129B, SRC, THY1 60 517 17535 2.826402321083172 1.0 0.8297440675675134 77.6880112549777
GOTERM_MF_DIRECT GO:0004714~transmembrane receptor protein tyrosine kinase activity 2 3.1746031746031744 0.09621089631728778 MET, ROS1 57 30 16650 19.473684210526315 0.9999999436269316 0.843482277647263 70.70940596804095
GOTERM_BP_DIRECT GO:0043388~positive regulation of DNA binding 2 3.1746031746031744 0.09928931689120717 MMP9, IGF1 60 31 17535 18.85483870967742 1.0 0.8324022965364269 78.88987060706458