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MLEssential

MLEssential is a computational toolbox to predict essential genes for yeast species using machine learning based on multi-scale information, including sequence features and evolution-based features.

Dependencies

  • Python==3.7.4
  • biopython==1.75
  • scikit-learn==0.22.1
  • numpy==1.17.2
  • scipy==1.3.1
  • pandas==0.25.1
  • seaborn==0.9.0

Schematic workflow for gene essentiality prediction using machine learning methods

image

Citation

Please cite this paper: Lu, H. et al. Yeast metabolic innovations emerged via expanded metabolic network and gene positive selection. Molecular Systems Biology 2021(17):e10427. https://www.embopress.org/doi/full/10.15252/msb.202110427.

Contributors