diff --git a/README.md b/README.md
index 49ca9ea..c32ec55 100644
--- a/README.md
+++ b/README.md
@@ -1 +1,18 @@
 # Clarity Portal
+
+## Install
+```bash
+python3.11 -m venv venv
+source venv/bin/activate
+pip install -r requirements.txt
+```
+
+## Development server
+```bash
+flask --app portal run --debug
+```
+
+## Production server
+```bash
+gunicorn -w 4 portal:app
+```
diff --git a/clarity_portal.py b/clarity_portal.py
deleted file mode 100644
index bd384b1..0000000
--- a/clarity_portal.py
+++ /dev/null
@@ -1,8 +0,0 @@
-from flask_script import Manager
-
-from portal import app
-
-manager = Manager(app)
-
-if __name__ == "__main__":
-    manager.run()
diff --git a/clarity_portal.wsgi b/clarity_portal.wsgi
deleted file mode 100644
index 4200720..0000000
--- a/clarity_portal.wsgi
+++ /dev/null
@@ -1,14 +0,0 @@
-"""Clarity Portal wsgi."""
-activate_this = '/var/www/html/clarity_portal/venv/bin/activate_this.py'
-execfile(activate_this, dict(__file__=activate_this))
-
-# Add app to the path
-import sys
-sys.path.insert(0, "/var/www/html/clarity_portal")
-
-# Load app
-from portal import app as application
-from portal.utils import WSGIMiddleware
-
-# Setup prefix
-application.wsgi_app = WSGIMiddleware(application.wsgi_app, "/clarity_portal")
diff --git a/portal/forms.py b/portal/forms.py
index 206aa2f..7b00019 100644
--- a/portal/forms.py
+++ b/portal/forms.py
@@ -30,7 +30,7 @@ class SubmitSampleForm(FlaskForm):
     parsed_samples = []
     sum_exome_count = 0
 
-    def validate(self):
+    def validate(self, extra_validators=[]):
         """Extra validation, used to validate submitted samples."""
         self.parsed_samples = []
         self.sum_exome_count = 0
@@ -154,7 +154,7 @@ class SubmitDXSampleForm(FlaskForm):
     parsed_samples = []
     sum_exome_count = 0
 
-    def validate(self):
+    def validate(self, extra_validators=[]):
         """Extra validation, used to validate submitted samples."""
         self.parsed_samples = {}
         self.parsed_worklist = {}
@@ -265,6 +265,7 @@ def validate(self):
         }
 
         for line in self.helix_worklist.data:
+            line = line.decode('utf-8')
             if not header:
                 header = line.rstrip().split(',')
                 for udf in udf_column:
diff --git a/requirements.txt b/requirements.txt
index d3774b8..ea7dfe4 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -1,5 +1,6 @@
-Flask==1.0.2
+Flask==2.3.3
 Flask-Bootstrap==3.3.7.1
-Flask-Script==2.0.6
-Flask-WTF==0.14.2
-genologics==0.3.24
+Flask-WTF==1.2.1
+genologics==1.0.0
+gunicorn==21.2.0
+six==1.16.0