Are k and n (powers of (in)activation) free parameters in model?

[pgleeson]

If so they should be listed as free parameters.

"it has been shown that for many voltage-gated ion channels the rate of activation to inactivation is 3:1" is a bit of an assumption to set k=3, n=4 for every ion channel.

[VahidGh]

At the beginning of my fits I was assuming them as free parameters but then I found almost all channels fitted well using the same values. Maybe this is due to the fact that at least 3 gates shall be moved in order to have ions passed through the pore. I'm still tracking this issue in case any exeption like channels with different structures do not work with this assumption.

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On Tue, 14 May 2019, 20:54 Padraig Gleeson, ***@***.***> wrote: If so they should be listed as free parameters. "it has been shown that for many voltage-gated ion channels the rate of activation to inactivation is 3:1" is a bit of an assumption to set k=3, n=4 for every ion channel. — You are receiving this because you are subscribed to this thread. Reply to this email directly, view it on GitHub <#2?email_source=notifications&email_token=ABSYZABBKHPD654VSGAWC43PVLRTRA5CNFSM4HM3TPSKYY3PNVWWK3TUL52HS4DFUVEXG43VMWVGG33NNVSW45C7NFSM4GTXBRYA>, or mute the thread <https://github.com/notifications/unsubscribe-auth/ABSYZAFMHRWXIPJVLYU3ZLDPVLRTRANCNFSM4HM3TPSA> .