diff --git a/plugins/optimization-detective/storage/rest-api.php b/plugins/optimization-detective/storage/rest-api.php
index ead4514671..7aa7714357 100644
--- a/plugins/optimization-detective/storage/rest-api.php
+++ b/plugins/optimization-detective/storage/rest-api.php
@@ -88,6 +88,35 @@ function od_register_endpoint(): void {
 }
 add_action( 'rest_api_init', 'od_register_endpoint' );
 
+/**
+ * Determines if the HTTP origin is an authorized one.
+ *
+ * Note that `is_allowed_http_origin()` is not used directly because the underlying `get_allowed_http_origins()` does
+ * not account for the URL port (although there is a to-do comment committed in core to address this). Additionally,
+ * the `is_allowed_http_origin()` function in core for some reason returns a string rather than a boolean.
+ *
+ * @since n.e.x.t
+ *
+ * @see get_allowed_http_origins()
+ * @see is_allowed_http_origin()
+ *
+ * @param string $origin Origin to check.
+ * @return bool Whether the origin is allowed.
+ */
+function od_is_allowed_http_origin( string $origin ): bool {
+	$allowed_origins = get_allowed_http_origins();
+	$home_url_port   = wp_parse_url( home_url(), PHP_URL_PORT );
+	if ( is_int( $home_url_port ) ) {
+		$allowed_origins = array_map(
+			static function ( string $allowed_origin ) use ( $home_url_port ): string {
+				return $allowed_origin . ':' . (string) $home_url_port;
+			},
+			$allowed_origins
+		);
+	}
+	return in_array( $origin, $allowed_origins, true );
+}
+
 /**
  * Handles REST API request to store metrics.
  *
@@ -102,7 +131,7 @@ function od_register_endpoint(): void {
 function od_handle_rest_request( WP_REST_Request $request ) {
 	// Block cross-origin storage requests since by definition URL Metrics data can only be sourced from the frontend of the site.
 	$origin = $request->get_header( 'origin' );
-	if ( null === $origin || home_url() !== $origin ) {
+	if ( null === $origin || ! od_is_allowed_http_origin( $origin ) ) {
 		return new WP_Error(
 			'rest_cross_origin_forbidden',
 			__( 'Cross-origin requests are not allowed for this endpoint.', 'optimization-detective' ),
diff --git a/plugins/optimization-detective/tests/storage/test-rest-api.php b/plugins/optimization-detective/tests/storage/test-rest-api.php
index b92db9d308..7d64b7463d 100644
--- a/plugins/optimization-detective/tests/storage/test-rest-api.php
+++ b/plugins/optimization-detective/tests/storage/test-rest-api.php
@@ -245,6 +245,7 @@ public function test_rest_request_bad_params( array $params ): void {
 	 *
 	 * @covers ::od_register_endpoint
 	 * @covers ::od_handle_rest_request
+	 * @covers ::od_is_allowed_http_origin
 	 */
 	public function test_rest_request_without_origin(): void {
 		$request = new WP_REST_Request( 'POST', self::ROUTE );
@@ -260,6 +261,7 @@ public function test_rest_request_without_origin(): void {
 	 *
 	 * @covers ::od_register_endpoint
 	 * @covers ::od_handle_rest_request
+	 * @covers ::od_is_allowed_http_origin
 	 */
 	public function test_rest_request_cross_origin(): void {
 		$request = new WP_REST_Request( 'POST', self::ROUTE );
@@ -271,6 +273,25 @@ public function test_rest_request_cross_origin(): void {
 		$this->assertSame( 0, did_action( 'od_url_metric_stored' ) );
 	}
 
+	/**
+	 * Test REST API request when 'home_url' is filtered.
+	 *
+	 * @covers ::od_register_endpoint
+	 * @covers ::od_handle_rest_request
+	 * @covers ::od_is_allowed_http_origin
+	 */
+	public function test_rest_request_origin_when_home_url_filtered(): void {
+		$request = $this->create_request( $this->get_valid_params() );
+		add_filter(
+			'home_url',
+			static function ( string $url ): string {
+				return trailingslashit( $url ) . 'home/en/?foo=bar#baz';
+			}
+		);
+		$response = rest_get_server()->dispatch( $request );
+		$this->assertSame( 200, $response->get_status() );
+	}
+
 	/**
 	 * Test not sending JSON data.
 	 *