diff --git a/.changes/next-release/bugfix-Waiter-88466.json b/.changes/next-release/bugfix-Waiter-88466.json
new file mode 100644
index 0000000000..35e969b4cb
--- /dev/null
+++ b/.changes/next-release/bugfix-Waiter-88466.json
@@ -0,0 +1,5 @@
+{
+  "type": "bugfix",
+  "category": "Waiter",
+  "description": "Update waiters to handle expected boolean values when matching errors (`boto/botocore#3220 <https://github.com/boto/botocore/issues/3220>`__)"
+}
diff --git a/botocore/waiter.py b/botocore/waiter.py
index 2362eebeda..47f71886d4 100644
--- a/botocore/waiter.py
+++ b/botocore/waiter.py
@@ -302,7 +302,15 @@ def acceptor_matches(response):
             # response.  So response is still a dictionary, and in the case
             # of an error response will contain the "Error" and
             # "ResponseMetadata" key.
-            return response.get("Error", {}).get("Code", "") == expected
+            # When expected is True, accept any error code.
+            # When expected is False, check if any errors were encountered.
+            # Otherwise, check for a specific AWS error code.
+            if expected is True:
+                return "Error" in response and "Code" in response["Error"]
+            elif expected is False:
+                return "Error" not in response
+            else:
+                return response.get("Error", {}).get("Code", "") == expected
 
         return acceptor_matches
 
diff --git a/tests/unit/test_waiters.py b/tests/unit/test_waiters.py
index 62544e180a..7ec9b23e5c 100644
--- a/tests/unit/test_waiters.py
+++ b/tests/unit/test_waiters.py
@@ -189,6 +189,38 @@ def test_single_waiter_supports_error(self):
             success_acceptor({'Error': {'Code': 'DoesNotExistErorr'}})
         )
 
+    def test_single_waiter_supports_no_error(self):
+        single_waiter = {
+            'acceptors': [
+                {
+                    'state': 'success',
+                    'matcher': 'error',
+                    'expected': False,
+                }
+            ],
+        }
+        single_waiter.update(self.boiler_plate_config)
+        config = SingleWaiterConfig(single_waiter)
+        success_acceptor = config.acceptors[0].matcher_func
+        self.assertTrue(success_acceptor({}))
+        self.assertFalse(success_acceptor({'Error': {'Code': 'ExampleError'}}))
+
+    def test_single_waiter_supports_any_error(self):
+        single_waiter = {
+            'acceptors': [
+                {
+                    'state': 'success',
+                    'matcher': 'error',
+                    'expected': True,
+                }
+            ],
+        }
+        single_waiter.update(self.boiler_plate_config)
+        config = SingleWaiterConfig(single_waiter)
+        success_acceptor = config.acceptors[0].matcher_func
+        self.assertTrue(success_acceptor({'Error': {'Code': 'ExampleError1'}}))
+        self.assertTrue(success_acceptor({'Error': {'Code': 'ExampleError2'}}))
+
     def test_unknown_matcher(self):
         unknown_type = 'arbitrary_type'
         single_waiter = {