diff --git a/requirements.txt b/requirements.txt
index 900e2c36..511f5337 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -3,7 +3,7 @@
 argo-ams-library
 certifi<2020.4.5.2  # Used by AMS (via requests), 2020.4.5.2 dropped support for Python 2
 pyopenssl<=21.0.0  # 22.0.0 dropped support for Python 2
-cryptography==3.3.0  # Crypto dropped support for Python 2 after 3.3.  They're now on 41.X...
+cryptography==42.0.0  # Crypto dropped support for Python 2 after 3.3.  They're now on 41.X...
 stomp.py<5.0.0
 python-daemon<=2.3.0  # 2.3.1 dropped support for Python 2
 python-ldap<3.4.0  # python-ldap-3.4.0 dropped support for Python 2
diff --git a/setup.py b/setup.py
index a495ca0c..9c49035a 100644
--- a/setup.py
+++ b/setup.py
@@ -51,7 +51,7 @@ def main():
           download_url='https://github.com/apel/ssm/releases',
           license='Apache License, Version 2.0',
           install_requires=[
-              'cryptography==3.3.0',
+              'cryptography==42.0.0',
               'stomp.py<5.0.0',
               'python-ldap<3.4.0',
               'setuptools',