How DEXseq handles large samples

[zhang-HZAU]

Hello, DEXseq team,

I am currently using DEXseq for alternative splicing analysis. After reading the official documents and my own practical application, I found that when the sample size exceeds 20, the calculation will always stop at the DEXSeq() function. At present, BPPARAM = MultiCoreParam() has been used according to the document and genes with too many 0 values ​​have been deleted.

May I ask, can the BatchJobsParam() mentioned in the documentation for use with large samples provide instructions or examples for adapting to the DEXseq project?

Thanks in advance for any suggestions.