diff --git a/src/main/java/io/asyncer/r2dbc/mysql/MySqlConnection.java b/src/main/java/io/asyncer/r2dbc/mysql/MySqlConnection.java
index c2bedf146..6a0abd852 100644
--- a/src/main/java/io/asyncer/r2dbc/mysql/MySqlConnection.java
+++ b/src/main/java/io/asyncer/r2dbc/mysql/MySqlConnection.java
@@ -33,6 +33,7 @@
 import io.r2dbc.spi.Connection;
 import io.r2dbc.spi.IsolationLevel;
 import io.r2dbc.spi.Lifecycle;
+import io.r2dbc.spi.R2dbcNonTransientResourceException;
 import io.r2dbc.spi.TransactionDefinition;
 import io.r2dbc.spi.ValidationDepth;
 import org.jetbrains.annotations.Nullable;
@@ -74,6 +75,10 @@ public final class MySqlConnection implements Connection, Lifecycle, ConnectionS
 
     private static final ServerVersion MYSQL_8 = ServerVersion.create(8, 0, 0);
 
+    private static final ServerVersion MYSQL_5_7_4 = ServerVersion.create(5, 7, 4);
+
+    private static final ServerVersion MARIA_10_2_0 = ServerVersion.create(10, 2, 0, true);
+
     private static final BiConsumer<ServerMessage, SynchronousSink<Boolean>> PING = (message, sink) -> {
         if (message instanceof ErrorMessage) {
             ErrorMessage msg = (ErrorMessage) message;
@@ -396,9 +401,28 @@ public Mono<Void> setLockWaitTimeout(Duration timeout) {
     @Override
     public Mono<Void> setStatementTimeout(Duration timeout) {
         requireNonNull(timeout, "timeout must not be null");
+        final boolean isMariaDb = context.getCapability().isMariaDb();
+        final ServerVersion serverVersion = context.getServerVersion();
+        final long timeoutMs = timeout.toMillis();
+        final String sql = isMariaDb ? "SET max_statement_time=" + timeoutMs / 1000.0
+                : "SET SESSION MAX_EXECUTION_TIME=" + timeoutMs;
+
+        // mariadb: https://mariadb.com/kb/en/aborting-statements/
+        // mysql: https://dev.mysql.com/blog-archive/server-side-select-statement-timeouts/
+        // ref: https://github.com/mariadb-corporation/mariadb-connector-r2dbc
+        if (isMariaDb && serverVersion.isGreaterThanOrEqualTo(MARIA_10_2_0)
+            || !isMariaDb && serverVersion.isGreaterThanOrEqualTo(MYSQL_5_7_4)) {
+            return QueryFlow.executeVoid(client, sql);
+        }
 
-        // TODO: implement me
-        return Mono.empty();
+        return Mono.error(
+                new R2dbcNonTransientResourceException(
+                        "Statement timeout is not supported by server version " + serverVersion,
+                        "HY000",
+                        -1,
+                        sql
+                )
+        );
     }
 
     boolean isSessionAutoCommit() {
diff --git a/src/main/java/io/asyncer/r2dbc/mysql/message/server/ErrorMessage.java b/src/main/java/io/asyncer/r2dbc/mysql/message/server/ErrorMessage.java
index 9dee369ee..a7ef07fb8 100644
--- a/src/main/java/io/asyncer/r2dbc/mysql/message/server/ErrorMessage.java
+++ b/src/main/java/io/asyncer/r2dbc/mysql/message/server/ErrorMessage.java
@@ -74,6 +74,8 @@ public R2dbcException toException() {
     }
 
     public R2dbcException toException(@Nullable String sql) {
+        // mysql: https://dev.mysql.com/doc/mysql-errors/8.0/en/server-error-reference.html
+        // mariadb: https://mariadb.com/kb/en/mariadb-error-code-reference/
         // Should keep looking more error codes
         switch (code) {
             case 1044: // Database access denied
@@ -93,6 +95,8 @@ public R2dbcException toException(@Nullable String sql) {
                 return new R2dbcTransientResourceException(message, sqlState, code);
             case 1205: // Wait lock timeout
             case 1907: // Statement executing timeout
+            case 3024: // Query execution was interrupted, maximum statement execution time exceeded
+            case 1969: // Query execution was interrupted
                 return new R2dbcTimeoutException(message, sqlState, code);
             case 1613: // Transaction rollback because of took too long
                 return new R2dbcRollbackException(message, sqlState, code);
diff --git a/src/test/java/io/asyncer/r2dbc/mysql/IntegrationTestSupport.java b/src/test/java/io/asyncer/r2dbc/mysql/IntegrationTestSupport.java
index 11e754e99..3f81a383d 100644
--- a/src/test/java/io/asyncer/r2dbc/mysql/IntegrationTestSupport.java
+++ b/src/test/java/io/asyncer/r2dbc/mysql/IntegrationTestSupport.java
@@ -17,6 +17,7 @@
 package io.asyncer.r2dbc.mysql;
 
 import io.r2dbc.spi.R2dbcBadGrammarException;
+import io.r2dbc.spi.R2dbcTimeoutException;
 import io.r2dbc.spi.Result;
 import org.jetbrains.annotations.Nullable;
 import org.reactivestreams.Publisher;
@@ -50,6 +51,10 @@ void badGrammar(Function<? super MySqlConnection, Publisher<?>> runner) {
         process(runner).verifyError(R2dbcBadGrammarException.class);
     }
 
+    void timeout(Function<? super MySqlConnection, Publisher<?>> runner) {
+        process(runner).verifyError(R2dbcTimeoutException.class);
+    }
+
     void illegalArgument(Function<? super MySqlConnection, Publisher<?>> runner) {
         process(runner).expectError(IllegalArgumentException.class).verify(Duration.ofSeconds(3));
     }
@@ -136,4 +141,21 @@ boolean envIsLessThanMySql57OrMariaDb102() {
 
         return ver.isLessThan(ServerVersion.create(5, 7, 0));
     }
+
+    boolean envIsLessThanMySql574OrMariaDb102() {
+        String version = System.getProperty("test.mysql.version");
+
+        if (version == null || version.isEmpty()) {
+            return true;
+        }
+
+        ServerVersion ver = ServerVersion.parse(version);
+        String type = System.getProperty("test.db.type");
+
+        if ("mariadb".equalsIgnoreCase(type)) {
+            return ver.isLessThan(ServerVersion.create(10, 2, 0));
+        }
+
+        return ver.isLessThan(ServerVersion.create(5, 7, 4));
+    }
 }
diff --git a/src/test/java/io/asyncer/r2dbc/mysql/QueryIntegrationTestSupport.java b/src/test/java/io/asyncer/r2dbc/mysql/QueryIntegrationTestSupport.java
index d03811faf..9a0051457 100644
--- a/src/test/java/io/asyncer/r2dbc/mysql/QueryIntegrationTestSupport.java
+++ b/src/test/java/io/asyncer/r2dbc/mysql/QueryIntegrationTestSupport.java
@@ -612,6 +612,17 @@ void testUnionQueryWithJsonColumnDecodedAsString() {
         );
     }
 
+    @Test
+    @DisabledIf("envIsLessThanMySql574OrMariaDb102")
+    void setStatementTimeoutTest() {
+        final String sql = "SELECT 1 WHERE SLEEP(1) > 1";
+        timeout(connection -> connection.setStatementTimeout(Duration.ofMillis(500))
+                .then(Mono.from(connection.createStatement(sql).execute()))
+                .flatMapMany(result -> Mono.from(result.map((row, metadata) -> row.get(0, String.class))))
+                .doOnNext(it -> System.out.println(it))
+        );
+    }
+
     private static JsonNode parseJson(String json) {
         ObjectMapper mapper = new ObjectMapper();
         try {