diff --git a/src/main/java/io/asyncer/r2dbc/mysql/MySqlConnection.java b/src/main/java/io/asyncer/r2dbc/mysql/MySqlConnection.java
index aa3fb961e..771a923e9 100644
--- a/src/main/java/io/asyncer/r2dbc/mysql/MySqlConnection.java
+++ b/src/main/java/io/asyncer/r2dbc/mysql/MySqlConnection.java
@@ -33,6 +33,7 @@
 import io.r2dbc.spi.Connection;
 import io.r2dbc.spi.IsolationLevel;
 import io.r2dbc.spi.Lifecycle;
+import io.r2dbc.spi.R2dbcNonTransientResourceException;
 import io.r2dbc.spi.TransactionDefinition;
 import io.r2dbc.spi.ValidationDepth;
 import org.jetbrains.annotations.Nullable;
@@ -74,6 +75,10 @@ public final class MySqlConnection implements Connection, Lifecycle, ConnectionS
 
     private static final ServerVersion MYSQL_8 = ServerVersion.create(8, 0, 0);
 
+    private static final ServerVersion MYSQL_STATEMENT_TIMEOUT = ServerVersion.create(5, 7, 4);
+
+    private static final ServerVersion MARIA_STATEMENT_TIMEOUT = ServerVersion.create(10, 2, 0);
+
     private static final BiConsumer<ServerMessage, SynchronousSink<Boolean>> PING = (message, sink) -> {
         if (message instanceof ErrorMessage) {
             ErrorMessage msg = (ErrorMessage) message;
@@ -396,21 +401,26 @@ public Mono<Void> setLockWaitTimeout(Duration timeout) {
     @Override
     public Mono<Void> setStatementTimeout(Duration timeout) {
         requireNonNull(timeout, "timeout must not be null");
-        final ServerVersion supportedVersion = ServerVersion.create(5, 7, 4);
-        long time = timeout.toMillis();
-        ServerVersion serverVersion = context.getServerVersion();
-        boolean serverSupportTimeout =  serverVersion.isGreaterThanOrEqualTo(supportedVersion);
-
-        if (!serverSupportTimeout) {
-            return Mono.defer(() -> Mono.error(new RuntimeException(
-                    "Query timeout is not supported by the server. (Required MySQL 5.7.4+)")));
+        final boolean isMariaDb = context.getCapability().isMariaDb();
+        final ServerVersion serverVersion = context.getServerVersion();
+        final String sql = isMariaDb ? "SET max_statement_time=" + timeout.getSeconds()
+                : "SET SESSION MAX_EXECUTION_TIME=" + timeout.toMillis();
+
+        // mariadb: https://mariadb.com/kb/en/aborting-statements/
+        // mysql: https://dev.mysql.com/blog-archive/server-side-select-statement-timeouts/
+        if (isMariaDb && serverVersion.isGreaterThanOrEqualTo(MARIA_STATEMENT_TIMEOUT)
+            || !isMariaDb && serverVersion.isGreaterThanOrEqualTo(MYSQL_STATEMENT_TIMEOUT)) {
+            return QueryFlow.executeVoid(client, sql);
         }
 
-        String sqlStatement = String.format("SET SESSION MAX_EXECUTION_TIME=%s", time);
-        return QueryFlow.execute(client, sqlStatement)
-                .doOnError(error -> {
-                    logger.error("Error setting statement timeout", error);
-                }).then();
+        return Mono.error(
+                new R2dbcNonTransientResourceException(
+                        "Statement timeout is not supported by server version " + serverVersion,
+                        "HY000",
+                        -1,
+                        sql
+                )
+        );
     }
 
     boolean isSessionAutoCommit() {