-
Notifications
You must be signed in to change notification settings - Fork 0
/
Copy pathAbout.html
125 lines (120 loc) · 16.6 KB
/
About.html
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
<!DOCTYPE html>
<html style="font-size: 16px;">
<head>
<meta name="viewport" content="width=device-width, initial-scale=1.0">
<meta charset="utf-8">
<meta name="keywords" content="About">
<meta name="description" content="">
<meta name="page_type" content="np-template-header-footer-from-plugin">
<title>About</title>
<link rel="stylesheet" href="nicepage.css" media="screen">
<link rel="stylesheet" href="About.css" media="screen">
<script class="u-script" type="text/javascript" src="jquery.js" defer=""></script>
<script class="u-script" type="text/javascript" src="nicepage.js" defer=""></script>
<meta name="generator" content="Nicepage 3.15.3, nicepage.com">
<link id="u-theme-google-font" rel="stylesheet" href="https://fonts.googleapis.com/css?family=Roboto+Condensed:300,300i,400,400i,700,700i|Open+Sans:300,300i,400,400i,600,600i,700,700i,800,800i">
<script type="application/ld+json">{
"@context": "http://schema.org",
"@type": "Organization",
"name": "",
"url": "index.html",
"logo": "images/53b33f797086135fb8a6ad24aa93a9e8fa0272e6176935639431dc784b539f5908f5dd60757bcb3c6bd4953a771089a2bdfdd20767001ec1d151e5_1280.png",
"sameAs": [
"https://github.com/neurogenomics",
"mailto:nskene@ic.ac.uk?subject=Rare%20Disease%20EWCE%20Contact",
"https://www.neurogenomics.co.uk/"
]
}</script>
<meta property="og:title" content="About">
<meta property="og:type" content="website">
<meta name="theme-color" content="#478ac9">
<link rel="canonical" href="index.html">
<meta property="og:url" content="index.html">
</head>
<body class="u-body"><header class="u-align-center-sm u-align-center-xs u-clearfix u-header u-header" id="sec-5ef1"><div class="u-clearfix u-sheet u-sheet-1">
<a href="https://nicepage.com" class="u-image u-logo u-image-1" data-image-width="1280" data-image-height="938">
<img src="images/53b33f797086135fb8a6ad24aa93a9e8fa0272e6176935639431dc784b539f5908f5dd60757bcb3c6bd4953a771089a2bdfdd20767001ec1d151e5_1280.png" class="u-logo-image u-logo-image-1" data-image-width="63">
</a>
<div class="u-social-icons u-spacing-10 u-social-icons-1">
<a class="u-social-url" target="_blank" title="Github" href="https://github.com/neurogenomics"><span class="u-icon u-icon-circle u-social-github u-social-icon u-icon-1"><svg class="u-svg-link" preserveAspectRatio="xMidYMin slice" viewBox="0 0 112 112" style=""><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#svg-1896"></use></svg><svg class="u-svg-content" viewBox="0 0 112 112" x="0" y="0" id="svg-1896"><circle fill="currentColor" cx="56.1" cy="56.1" r="55"></circle><path fill="#FFFFFF" d="M88,51.3c0-5.5-1.9-10.2-5.3-13.7c0.6-1.3,2.3-6.5-0.5-13.5c0,0-4.2-1.4-14,5.3c-4.1-1.1-8.4-1.7-12.7-1.8
c-4.3,0-8.7,0.6-12.7,1.8c-9.7-6.6-14-5.3-14-5.3c-2.8,7-1,12.2-0.5,13.5C25,41.2,23,45.7,23,51.3c0,19.6,11.9,23.9,23.3,25.2
c-1.5,1.3-2.8,3.5-3.2,6.8c-3,1.3-10.2,3.6-14.9-4.3c0,0-2.7-4.9-7.8-5.3c0,0-5-0.1-0.4,3.1c0,0,3.3,1.6,5.6,7.5c0,0,3,9.1,17.2,6
c0,4.3,0.1,8.3,0.1,9.5h25.2c0-1.7,0.1-7.2,0.1-14c0-4.7-1.7-7.9-3.4-9.4C76,75.2,88,70.9,88,51.3z"></path></svg></span>
</a>
<a class="u-social-url" target="_blank" title="Email" href="mailto:nskene@ic.ac.uk?subject=Rare%20Disease%20EWCE%20Contact"><span class="u-icon u-icon-circle u-social-email u-social-icon u-icon-2"><svg class="u-svg-link" preserveAspectRatio="xMidYMin slice" viewBox="0 0 112 112" style=""><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#svg-d2bc"></use></svg><svg class="u-svg-content" viewBox="0 0 112 112" x="0" y="0" id="svg-d2bc"><circle fill="currentColor" cx="56.1" cy="56.1" r="55"></circle><path id="path3864" fill="#FFFFFF" d="M27.2,28h57.6c4,0,7.2,3.2,7.2,7.2l0,0v42.7c0,3.9-3.2,7.2-7.2,7.2l0,0H27.2
c-4,0-7.2-3.2-7.2-7.2V35.2C20,31.1,23.2,28,27.2,28 M56,52.9l28.8-17.8H27.2L56,52.9 M27.2,77.7h57.6V43.5L56,61.3L27.2,43.5V77.7z
"></path></svg></span>
</a>
<a class="u-social-url" target="_blank" title="Neurogenomcis lab website" href="https://www.neurogenomics.co.uk/"><span class="u-icon u-icon-circle u-social-custom u-social-icon u-icon-3"><svg class="u-svg-link" preserveAspectRatio="xMidYMin slice" viewBox="0 0 477.73 477.73" style=""><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#svg-42ee"></use></svg><svg class="u-svg-content" viewBox="0 0 477.73 477.73" x="0px" y="0px" id="svg-42ee" style="enable-background:new 0 0 477.73 477.73;"><g><g><path d="M433.562,100.983c-0.008-0.154-0.025-0.308-0.051-0.461c-0.597-0.853-1.331-1.587-1.946-2.423 c-4.46-6.076-9.182-11.924-14.165-17.545c-1.365-1.536-2.731-3.055-4.13-4.557c-5.131-5.495-10.513-10.735-16.145-15.718 c-1.041-0.922-2.014-1.877-3.055-2.782c-13.88-11.891-29.078-22.153-45.295-30.583c-0.649-0.341-1.331-0.631-1.997-0.973 c-7.222-3.67-14.627-6.969-22.187-9.882c-1.707-0.614-3.26-1.195-4.881-1.707c-6.724-2.423-13.551-4.545-20.48-6.366 c-2.048-0.546-4.096-1.109-6.178-1.587c-6.827-1.587-13.653-2.799-20.634-3.789c-2.116-0.307-4.198-0.717-6.332-0.973 c-17.979-2.185-36.156-2.185-54.136,0c-2.133,0.256-4.215,0.666-6.332,0.973c-6.98,0.99-13.875,2.202-20.634,3.789 c-2.082,0.478-4.13,1.041-6.178,1.587c-6.975,1.82-13.801,3.942-20.48,6.366c-1.707,0.58-3.26,1.161-4.881,1.707 c-7.559,2.913-14.965,6.211-22.187,9.882c-0.666,0.341-1.348,0.631-1.997,0.973c-16.271,8.421-31.52,18.682-45.449,30.583 c-1.041,0.904-2.014,1.86-3.055,2.782c-5.689,5.006-11.071,10.246-16.145,15.718c-1.399,1.502-2.765,3.021-4.13,4.557 c-4.995,5.609-9.717,11.457-14.165,17.544c-0.614,0.836-1.348,1.57-1.946,2.423c-0.078,0.149-0.147,0.303-0.205,0.461 c-58.866,82.497-58.866,193.267,0,275.763c0.058,0.158,0.126,0.312,0.205,0.461c0.597,0.853,1.331,1.587,1.946,2.423 c4.449,6.076,9.17,11.924,14.165,17.545c1.365,1.536,2.731,3.055,4.13,4.557c5.143,5.495,10.524,10.735,16.145,15.718 c1.041,0.922,2.014,1.877,3.055,2.782c13.88,11.891,29.078,22.153,45.295,30.583c0.649,0.341,1.331,0.631,1.997,0.973 c7.222,3.67,14.627,6.969,22.187,9.882c1.707,0.614,3.26,1.195,4.881,1.707c6.724,2.423,13.551,4.545,20.48,6.366 c2.048,0.546,4.096,1.109,6.178,1.587c6.827,1.587,13.653,2.799,20.634,3.789c2.116,0.307,4.198,0.717,6.332,0.973 c17.979,2.185,36.156,2.185,54.136,0c2.133-0.256,4.215-0.666,6.332-0.973c6.98-0.99,13.875-2.202,20.634-3.789 c2.082-0.478,4.13-1.041,6.178-1.587c6.986-1.82,13.813-3.942,20.48-6.366c1.707-0.58,3.26-1.161,4.881-1.707 c7.559-2.913,14.965-6.211,22.187-9.882c0.666-0.341,1.348-0.631,1.997-0.973c16.217-8.431,31.415-18.692,45.295-30.583 c1.041-0.905,2.014-1.86,3.055-2.782c5.689-4.995,11.071-10.234,16.145-15.718c1.399-1.502,2.765-3.021,4.13-4.557 c4.995-5.621,9.717-11.469,14.165-17.545c0.614-0.836,1.348-1.57,1.946-2.423c0.078-0.149,0.147-0.303,0.205-0.461 C492.428,294.25,492.428,183.48,433.562,100.983z M414.089,133.274c16.322,26.881,26.178,57.185,28.791,88.525H340.651 c-1.252-20.336-4.452-40.504-9.557-60.228C359.971,156.163,387.922,146.633,414.089,133.274z M282.368,38.775 c0.956,0.222,1.877,0.529,2.833,0.751c6.11,1.434,12.169,3.072,18.091,5.12c0.905,0.307,1.792,0.666,2.68,0.99 c5.871,2.048,11.656,4.318,17.323,6.827c0.99,0.461,1.963,0.973,2.953,1.434c5.427,2.583,10.729,5.376,15.906,8.38l3.413,2.065 c4.915,3.004,9.694,6.218,14.336,9.643c1.195,0.87,2.389,1.707,3.567,2.662c4.551,3.413,8.909,7.071,13.073,10.974 c1.092,0.99,2.219,1.963,3.294,2.987c4.369,4.147,8.533,8.533,12.561,13.073c0.512,0.597,1.058,1.143,1.57,1.707 c-23.109,11.013-47.59,18.877-72.789,23.381c-11.674-32.092-27.095-62.694-45.943-91.17 C277.606,38.025,280.03,38.264,282.368,38.775z M171.298,221.798c1.346-18.466,4.49-36.757,9.387-54.613 c19.337,2.297,38.793,3.436,58.266,3.413c19.491-0.006,38.965-1.174,58.317-3.499c4.888,17.885,8.015,36.205,9.335,54.699H171.298 z M306.603,255.932c-1.346,18.466-4.49,36.757-9.387,54.613c-19.337-2.297-38.793-3.436-58.266-3.413 c-19.49-0.022-38.963,1.117-58.317,3.413c-4.883-17.857-8.009-36.148-9.336-54.613H306.603z M238.95,45.193 c19.422,27.527,35.396,57.332,47.565,88.747c-15.799,1.678-31.676,2.521-47.565,2.526c-15.871-0.019-31.731-0.867-47.514-2.543 C203.62,102.529,219.575,72.734,238.95,45.193z M85.521,103.663c4.011-4.54,8.192-8.926,12.561-13.073 c1.075-1.024,2.202-1.997,3.294-2.987c4.21-3.834,8.568-7.492,13.073-10.974c1.178-0.905,2.372-1.707,3.567-2.662 c4.642-3.413,9.421-6.628,14.336-9.643l3.413-2.065c5.177-3.026,10.479-5.82,15.906-8.38c0.99-0.461,1.963-0.973,2.953-1.434 c5.666-2.56,11.452-4.83,17.323-6.827c0.887-0.324,1.707-0.683,2.679-0.99c5.922-1.98,11.947-3.618,18.091-5.12 c0.956-0.222,1.877-0.529,2.85-0.734c2.338-0.512,4.762-0.751,7.134-1.178c-18.856,28.481-34.282,59.089-45.961,91.187 c-25.199-4.504-49.681-12.368-72.789-23.381C84.463,104.806,85.009,104.26,85.521,103.663z M63.812,133.274 c26.161,13.358,54.106,22.888,82.978,28.297c-5.099,19.725-8.294,39.893-9.54,60.228H35.021 C37.635,190.459,47.491,160.155,63.812,133.274z M63.812,344.457c-16.322-26.881-26.178-57.185-28.791-88.525H137.25 c1.252,20.336,4.452,40.504,9.557,60.228C117.93,321.567,89.979,331.097,63.812,344.457z M195.533,438.955 c-0.956-0.222-1.877-0.529-2.833-0.751c-6.11-1.434-12.169-3.072-18.091-5.12c-0.905-0.307-1.792-0.666-2.68-0.99 c-5.871-2.048-11.656-4.318-17.323-6.827c-0.99-0.461-1.963-0.973-2.953-1.434c-5.427-2.583-10.729-5.376-15.906-8.38 l-3.413-2.065c-4.915-3.004-9.694-6.218-14.336-9.643c-1.195-0.87-2.389-1.707-3.567-2.662 c-4.551-3.413-8.909-7.071-13.073-10.974c-1.092-0.99-2.219-1.963-3.294-2.987c-4.369-4.147-8.533-8.533-12.561-13.073 c-0.512-0.597-1.058-1.143-1.57-1.707c23.109-11.013,47.59-18.877,72.789-23.381c11.674,32.092,27.095,62.694,45.943,91.17 C200.294,439.706,197.871,439.467,195.533,438.955z M238.95,432.538c-19.422-27.527-35.396-57.332-47.565-88.747 c31.607-3.402,63.488-3.402,95.095,0l-0.017,0.017C274.281,375.201,258.326,404.996,238.95,432.538z M392.38,374.067 c-4.011,4.54-8.192,8.926-12.561,13.073c-1.075,1.024-2.202,1.997-3.294,2.987c-4.21,3.846-8.568,7.504-13.073,10.974 c-1.178,0.904-2.372,1.792-3.567,2.662c-4.642,3.413-9.421,6.628-14.336,9.643l-3.413,2.065 c-5.166,3.015-10.468,5.808-15.906,8.38c-0.99,0.461-1.963,0.973-2.953,1.434c-5.666,2.56-11.452,4.83-17.323,6.827 c-0.887,0.324-1.707,0.683-2.679,0.99c-5.922,1.98-11.947,3.618-18.091,5.12c-0.956,0.222-1.877,0.529-2.85,0.734 c-2.338,0.512-4.762,0.751-7.134,1.178c18.848-28.476,34.27-59.078,45.943-91.17c25.199,4.504,49.681,12.368,72.789,23.381 C393.438,372.924,392.892,373.47,392.38,374.067z M414.089,344.457c-26.161-13.358-54.106-22.888-82.978-28.297 c5.099-19.725,8.294-39.893,9.54-60.228H442.88C440.266,287.271,430.41,317.575,414.089,344.457z"></path>
</g>
</g></svg></span>
</a>
</div>
<nav class="u-align-left u-menu u-menu-dropdown u-offcanvas u-menu-1">
<div class="menu-collapse" style="font-size: 1rem;">
<a class="u-button-style u-nav-link" href="#">
<svg class="u-svg-link" preserveAspectRatio="xMidYMin slice" viewBox="0 0 302 302" style=""><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#svg-8a8f"></use></svg>
<svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" version="1.1" id="svg-8a8f" x="0px" y="0px" viewBox="0 0 302 302" style="enable-background:new 0 0 302 302;" xml:space="preserve" class="u-svg-content"><g><rect y="36" width="302" height="30"></rect><rect y="236" width="302" height="30"></rect><rect y="136" width="302" height="30"></rect>
</g><g></g><g></g><g></g><g></g><g></g><g></g><g></g><g></g><g></g><g></g><g></g><g></g><g></g><g></g><g></g></svg>
</a>
</div>
<div class="u-custom-menu u-nav-container">
<ul class="u-nav u-spacing-2 u-unstyled u-nav-1"><li class="u-nav-item"><a class="u-active-grey-5 u-border-active-palette-1-base u-border-hover-palette-1-base u-button-style u-hover-grey-10 u-nav-link u-text-active-grey-90 u-text-grey-90 u-text-hover-grey-90" href="Home.html" style="padding: 10px 20px;">Home</a>
</li><li class="u-nav-item"><a class="u-active-grey-5 u-border-active-palette-1-base u-border-hover-palette-1-base u-button-style u-hover-grey-10 u-nav-link u-text-active-grey-90 u-text-grey-90 u-text-hover-grey-90" href="About.html" style="padding: 10px 20px;">About</a>
</li></ul>
</div>
<div class="u-custom-menu u-nav-container-collapse">
<div class="u-align-center u-black u-container-style u-inner-container-layout u-opacity u-opacity-95 u-sidenav">
<div class="u-sidenav-overflow">
<div class="u-menu-close"></div>
<ul class="u-align-center u-nav u-popupmenu-items u-unstyled u-nav-2"><li class="u-nav-item"><a class="u-button-style u-nav-link" href="Home.html" style="padding: 10px 20px;">Home</a>
</li><li class="u-nav-item"><a class="u-button-style u-nav-link" href="About.html" style="padding: 10px 20px;">About</a>
</li></ul>
</div>
</div>
<div class="u-black u-menu-overlay u-opacity u-opacity-70"></div>
</div>
</nav>
<h2 class="u-text u-text-1">Rare Disease EWCE</h2>
</div></header>
<section class="u-align-center u-clearfix u-grey-5 u-section-1" id="sec-6ec8">
<div class="u-clearfix u-sheet u-valign-middle u-sheet-1">
<h1 class="u-text u-text-1">About</h1>
<p class="u-text u-text-2">Expression weighted cell-type enrichment (<a href="https://bioconductor.org/packages/release/bioc/html/EWCE.html" class="u-active-none u-border-none u-btn u-button-link u-button-style u-hover-none u-none u-text-palette-1-base u-btn-1">EWCE</a>) analysis was performed with 100000 reps on over 9000 rare disease associated gene sets from the Human phenotype ontology (<a href="https://hpo.jax.org/app/" class="u-active-none u-border-none u-btn u-button-link u-button-style u-hover-none u-none u-text-palette-1-base u-btn-2">HPO</a>). The human scRNA-seq data required was obtained from the <a href="https://descartes.brotmanbaty.org/bbi/human-gene-expression-during-development/" class="u-active-none u-border-none u-btn u-button-link u-button-style u-hover-none u-none u-text-palette-1-base u-btn-3">Descaretes</a> human cell atalas. This allows us to identify the cell types that are significnatly associated with the primary genetic susceptibility for the disease. This site provides resources for retrieving subsets of the results, allowing specialists to make use of findings related to their field of study.
</p>
<a href="https://www.neurogenomics.co.uk/" class="u-btn u-btn-rectangle u-button-style u-color-scheme-summer-time u-color-style-multicolor-1 u-palette-2-base u-radius-0 u-btn-4" target="_blank">Neurogenomics lab</a>
</div>
</section>
<footer class="u-clearfix u-footer u-grey-80" id="sec-69cd"><div class="u-clearfix u-sheet u-sheet-1">
<a href="https://nicepage.com" class="u-image u-logo u-image-1" data-image-width="1280" data-image-height="938">
<img src="images/53b33f797086135fb8a6ad24aa93a9e8fa0272e6176935639431dc784b539f5908f5dd60757bcb3c6bd4953a771089a2bdfdd20767001ec1d151e5_1280.png" class="u-logo-image u-logo-image-1" data-image-width="80">
</a>
<nav class="u-menu u-menu-dropdown u-offcanvas u-menu-1">
<div class="menu-collapse">
<a class="u-button-style u-nav-link" href="#">
<svg><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#menu-hamburger"></use></svg>
<svg version="1.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><defs><symbol id="menu-hamburger" viewBox="0 0 16 16" style="width: 16px; height: 16px;"><rect y="1" width="16" height="2"></rect><rect y="7" width="16" height="2"></rect><rect y="13" width="16" height="2"></rect>
</symbol>
</defs></svg>
</a>
</div>
<div class="u-nav-container">
<ul class="u-nav u-unstyled"><li class="u-nav-item"><a class="u-button-style u-nav-link" href="Home.html">Home</a>
</li><li class="u-nav-item"><a class="u-button-style u-nav-link" href="About.html">About</a>
</li></ul>
</div>
<div class="u-nav-container-collapse">
<div class="u-black u-container-style u-inner-container-layout u-opacity u-opacity-95 u-sidenav">
<div class="u-sidenav-overflow">
<div class="u-menu-close"></div>
<ul class="u-align-center u-nav u-popupmenu-items u-unstyled u-nav-2"><li class="u-nav-item"><a class="u-button-style u-nav-link" href="Home.html">Home</a>
</li><li class="u-nav-item"><a class="u-button-style u-nav-link" href="About.html">About</a>
</li></ul>
</div>
</div>
<div class="u-black u-menu-overlay u-opacity u-opacity-70"></div>
</div>
</nav>
</div></footer>
</body>
</html>