biolink-model.proto

// Activity or behavior of any independent integral living, organization or mechanical actor in the world
message ActivityAndBehavior
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated regulatesProcessToProcess None = 12
  repeated hasParticipant None = 13
  repeated hasInput None = 14
  repeated hasOutput None = 15
  repeated precedes None = 16
 }
// A subcellular location, cell type or gross anatomical part
message AnatomicalEntity
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated expresses None = 13
  repeated inTaxon None = 14
 }
message AnatomicalEntityToAnatomicalEntityAssociation
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
 }
// A relationship between two anatomical entities where the relationship is ontogenic, i.e the two entities are related by development. A number of different relationship types can be used to specify the precise nature of the relationship
message AnatomicalEntityToAnatomicalEntityOntogenicAssociation
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
 }
// A relationship between two anatomical entities where the relationship is mereological, i.e the two entities are related by parthood. This includes relationships between cellular components and cells, between cells and tissues, tissues and whole organisms
message AnatomicalEntityToAnatomicalEntityPartOfAssociation
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
 }
// A typed association between two entities, supported by evidence
message Association
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
  optional hasConfidenceLevel None = 12
  optional hasEvidence None = 13
  optional stageQualifier None = 14
  optional quantifierQualifier None = 15
  optional frequencyQualifier None = 16
  optional severityQualifier None = 17
  optional sexQualifier None = 18
  optional onsetQualifier None = 19
  optional clinicalModifierQualifier None = 20
  optional sequenceVariantQualifier None = 21
  repeated changeIsCatalyzedBy None = 22
 }
// A property or characteristic of an entity. For example, an apple may have properties such as color, shape, age, crispiness. An environmental sample may have attributes such as depth, lat, long, material.
message Attribute
 {
  optional hasAttributeType None = 1
  repeated hasQuantitativeValue None = 2
  optional hasQualitativeValue None = 3
  id None = 4
  name None = 5
  repeated category None = 6
  repeated relatedTo None = 7
  repeated interactsWith None = 8
  optional nodeProperty None = 9
  optional iri None = 10
  repeated synonym None = 11
  optional fullName None = 12
  optional description None = 13
  repeated systematicSynonym None = 14
  repeated subclassOf None = 15
 }
// One or more causally connected executions of molecular functions
message BiologicalProcess
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated hasInput None = 13
  repeated hasOutput None = 14
  repeated enabledBy None = 15
  repeated regulatesProcessToProcess None = 16
  repeated hasParticipant None = 17
  repeated precedes None = 18
 }
// Either an individual molecular activity, or a collection of causally connected molecular activities
message BiologicalProcessOrActivity
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated hasInput None = 13
  repeated hasOutput None = 14
  repeated enabledBy None = 15
  repeated regulatesProcessToProcess None = 16
  repeated hasParticipant None = 17
  repeated precedes None = 18
 }
message BiologicalSex
 {
  optional hasAttributeType None = 1
  repeated hasQuantitativeValue None = 2
  optional hasQualitativeValue None = 3
  id None = 4
  name None = 5
  repeated category None = 6
  repeated relatedTo None = 7
  repeated interactsWith None = 8
  optional nodeProperty None = 9
  optional iri None = 10
  repeated synonym None = 11
  optional fullName None = 12
  optional description None = 13
  repeated systematicSynonym None = 14
  repeated subclassOf None = 15
 }
message Carbohydrate
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated molecularlyInteractsWith None = 13
  repeated affectsAbundanceOf None = 14
  repeated increasesAbundanceOf None = 15
  repeated decreasesAbundanceOf None = 16
  repeated affectsActivityOf None = 17
  repeated increasesActivityOf None = 18
  repeated decreasesActivityOf None = 19
  repeated affectsExpressionOf None = 20
  repeated increasesExpressionOf None = 21
  repeated decreasesExpressionOf None = 22
  repeated affectsFoldingOf None = 23
  repeated increasesFoldingOf None = 24
  repeated decreasesFoldingOf None = 25
  repeated affectsLocalizationOf None = 26
  repeated increasesLocalizationOf None = 27
  repeated decreasesLocalizationOf None = 28
  repeated affectsMetabolicProcessingOf None = 29
  repeated increasesMetabolicProcessingOf None = 30
  repeated decreasesMetabolicProcessingOf None = 31
  repeated affectsMolecularModificationOf None = 32
  repeated increasesMolecularModificationOf None = 33
  repeated decreasesMolecularModificationOf None = 34
  repeated affectsSynthesisOf None = 35
  repeated increasesSynthesisOf None = 36
  repeated decreasesSynthesisOf None = 37
  repeated affectsDegradationOf None = 38
  repeated increasesDegradationOf None = 39
  repeated decreasesDegradationOf None = 40
  repeated affectsMutationRateOf None = 41
  repeated increasesMutationRateOf None = 42
  repeated decreasesMutationRateOf None = 43
  repeated affectsResponseTo None = 44
  repeated increasesResponseTo None = 45
  repeated decreasesResponseTo None = 46
  repeated affectsSplicingOf None = 47
  repeated increasesSplicingOf None = 48
  repeated decreasesSplicingOf None = 49
  repeated affectsStabilityOf None = 50
  repeated increasesStabilityOf None = 51
  repeated decreasesStabilityOf None = 52
  repeated affectsTransportOf None = 53
  repeated increasesTransportOf None = 54
  repeated decreasesTransportOf None = 55
  repeated affectsSecretionOf None = 56
  repeated increasesSecretionOf None = 57
  repeated decreasesSecretionOf None = 58
  repeated affectsUptakeOf None = 59
  repeated increasesUptakeOf None = 60
  repeated decreasesUptakeOf None = 61
  repeated regulatesEntityToEntity None = 62
  repeated biomarkerFor None = 63
  repeated inTaxon None = 64
 }
// An individual organism that has a patient role in some clinical context.
message Case
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated inTaxon None = 13
 }
// An association between a case (e.g. individual patient) and a phenotypic feature in which the individual has or has had the phenotype
message CaseToPhenotypicFeatureAssociation
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
  optional sexQualifier None = 12
  optional frequencyQualifier None = 13
  optional severityQualifier None = 14
  optional onsetQualifier None = 15
 }
message Cell
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated expresses None = 13
  repeated inTaxon None = 14
 }
message CellLine
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
 }
// An relationship between a cell line and a disease or a phenotype, where the cell line is derived from an individual with that disease or phenotype
message CellLineToDiseaseOrPhenotypicFeatureAssociation
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
 }
// A location in or around a cell
message CellularComponent
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated expresses None = 13
  repeated inTaxon None = 14
 }
// May be a chemical entity or a formulation with a chemical entity as active ingredient, or a complex material with multiple chemical entities as part
message ChemicalSubstance
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated molecularlyInteractsWith None = 13
  repeated affectsAbundanceOf None = 14
  repeated increasesAbundanceOf None = 15
  repeated decreasesAbundanceOf None = 16
  repeated affectsActivityOf None = 17
  repeated increasesActivityOf None = 18
  repeated decreasesActivityOf None = 19
  repeated affectsExpressionOf None = 20
  repeated increasesExpressionOf None = 21
  repeated decreasesExpressionOf None = 22
  repeated affectsFoldingOf None = 23
  repeated increasesFoldingOf None = 24
  repeated decreasesFoldingOf None = 25
  repeated affectsLocalizationOf None = 26
  repeated increasesLocalizationOf None = 27
  repeated decreasesLocalizationOf None = 28
  repeated affectsMetabolicProcessingOf None = 29
  repeated increasesMetabolicProcessingOf None = 30
  repeated decreasesMetabolicProcessingOf None = 31
  repeated affectsMolecularModificationOf None = 32
  repeated increasesMolecularModificationOf None = 33
  repeated decreasesMolecularModificationOf None = 34
  repeated affectsSynthesisOf None = 35
  repeated increasesSynthesisOf None = 36
  repeated decreasesSynthesisOf None = 37
  repeated affectsDegradationOf None = 38
  repeated increasesDegradationOf None = 39
  repeated decreasesDegradationOf None = 40
  repeated affectsMutationRateOf None = 41
  repeated increasesMutationRateOf None = 42
  repeated decreasesMutationRateOf None = 43
  repeated affectsResponseTo None = 44
  repeated increasesResponseTo None = 45
  repeated decreasesResponseTo None = 46
  repeated affectsSplicingOf None = 47
  repeated increasesSplicingOf None = 48
  repeated decreasesSplicingOf None = 49
  repeated affectsStabilityOf None = 50
  repeated increasesStabilityOf None = 51
  repeated decreasesStabilityOf None = 52
  repeated affectsTransportOf None = 53
  repeated increasesTransportOf None = 54
  repeated decreasesTransportOf None = 55
  repeated affectsSecretionOf None = 56
  repeated increasesSecretionOf None = 57
  repeated decreasesSecretionOf None = 58
  repeated affectsUptakeOf None = 59
  repeated increasesUptakeOf None = 60
  repeated decreasesUptakeOf None = 61
  repeated regulatesEntityToEntity None = 62
  repeated biomarkerFor None = 63
  repeated inTaxon None = 64
 }
// A relationship between two chemical entities. This can encompass actual interactions as well as temporal causal edges, e.g. one chemical converted to another.
message ChemicalToChemicalAssociation
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
 }
// A causal relationship between two chemical entities, where the subject represents the upstream entity and the object represents the downstream. For any such association there is an implicit reaction:
//   IF
//   R has-input C1 AND
//   R has-output C2 AND
//   R enabled-by P AND
//   R type Reaction
//   THEN
//   C1 derives-into C2 <<change is catalyzed by P>>
message ChemicalToChemicalDerivationAssociation
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
  repeated changeIsCatalyzedBy None = 12
 }
// An interaction between a chemical entity and a phenotype or disease, where the presence of the chemical gives rise to or exacerbates the phenotype
message ChemicalToDiseaseOrPhenotypicFeatureAssociation
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
 }
// An interaction between a chemical entity and a gene or gene product
message ChemicalToGeneAssociation
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
 }
// An interaction between a chemical entity and a biological process or pathway
message ChemicalToPathwayAssociation
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
 }
// Any entity or process that exists in the clinical domain and outside the biological realm. Diseases are placed under biological entities
message ClinicalEntity
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
 }
message ClinicalIntervention
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
 }
// Used to characterize and specify the phenotypic abnormalities defined in the Phenotypic abnormality subontology, with respect to severity, laterality, age of onset, and other aspects
message ClinicalModifier
 {
  optional hasAttributeType None = 1
  repeated hasQuantitativeValue None = 2
  optional hasQualitativeValue None = 3
  id None = 4
  name None = 5
  repeated category None = 6
  repeated relatedTo None = 7
  repeated interactsWith None = 8
  optional nodeProperty None = 9
  optional iri None = 10
  repeated synonym None = 11
  optional fullName None = 12
  optional description None = 13
  repeated systematicSynonym None = 14
  repeated subclassOf None = 15
 }
message ClinicalTrial
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
 }
message CodingSequence
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated molecularlyInteractsWith None = 13
  repeated affectsAbundanceOf None = 14
  repeated increasesAbundanceOf None = 15
  repeated decreasesAbundanceOf None = 16
  repeated affectsActivityOf None = 17
  repeated increasesActivityOf None = 18
  repeated decreasesActivityOf None = 19
  repeated affectsExpressionOf None = 20
  repeated increasesExpressionOf None = 21
  repeated decreasesExpressionOf None = 22
  repeated affectsFoldingOf None = 23
  repeated increasesFoldingOf None = 24
  repeated decreasesFoldingOf None = 25
  repeated affectsLocalizationOf None = 26
  repeated increasesLocalizationOf None = 27
  repeated decreasesLocalizationOf None = 28
  repeated affectsMetabolicProcessingOf None = 29
  repeated increasesMetabolicProcessingOf None = 30
  repeated decreasesMetabolicProcessingOf None = 31
  repeated affectsMolecularModificationOf None = 32
  repeated increasesMolecularModificationOf None = 33
  repeated decreasesMolecularModificationOf None = 34
  repeated affectsSynthesisOf None = 35
  repeated increasesSynthesisOf None = 36
  repeated decreasesSynthesisOf None = 37
  repeated affectsDegradationOf None = 38
  repeated increasesDegradationOf None = 39
  repeated decreasesDegradationOf None = 40
  repeated affectsMutationRateOf None = 41
  repeated increasesMutationRateOf None = 42
  repeated decreasesMutationRateOf None = 43
  repeated affectsResponseTo None = 44
  repeated increasesResponseTo None = 45
  repeated decreasesResponseTo None = 46
  repeated affectsSplicingOf None = 47
  repeated increasesSplicingOf None = 48
  repeated decreasesSplicingOf None = 49
  repeated affectsStabilityOf None = 50
  repeated increasesStabilityOf None = 51
  repeated decreasesStabilityOf None = 52
  repeated affectsTransportOf None = 53
  repeated increasesTransportOf None = 54
  repeated decreasesTransportOf None = 55
  repeated affectsSecretionOf None = 56
  repeated increasesSecretionOf None = 57
  repeated decreasesSecretionOf None = 58
  repeated affectsUptakeOf None = 59
  repeated increasesUptakeOf None = 60
  repeated decreasesUptakeOf None = 61
  repeated regulatesEntityToEntity None = 62
  repeated biomarkerFor None = 63
  repeated inTaxon None = 64
  optional hasBiologicalSequence None = 65
 }
// Level of confidence in a statement
message ConfidenceLevel
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
 }
message DataFile
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
 }
message DataSet
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
 }
message DataSetVersion
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  optional title None = 12
  optional sourceDataFile None = 13
  optional versionOf None = 14
  optional type None = 15
  optional distribution None = 16
 }
// A thing made or adapted for a particular purpose, especially a piece of mechanical or electronic equipment
message Device
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
 }
message Disease
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated correlatedWith None = 13
  repeated hasBiomarker None = 14
  repeated treatedBy None = 15
  repeated inTaxon None = 16
 }
// Either one of a disease or an individual phenotypic feature. Some knowledge resources such as Monarch treat these as distinct, others such as MESH conflate.
message DiseaseOrPhenotypicFeature
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated correlatedWith None = 13
  repeated hasBiomarker None = 14
  repeated treatedBy None = 15
  repeated inTaxon None = 16
 }
// An association between either a disease or a phenotypic feature and an anatomical entity, where the disease/feature manifests in that site.
message DiseaseOrPhenotypicFeatureAssociationToLocationAssociation
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
 }
// An association between a disease and a phenotypic feature in which the phenotypic feature is associated with the disease in some way
message DiseaseToPhenotypicFeatureAssociation
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
  optional sexQualifier None = 12
  optional frequencyQualifier None = 13
  optional severityQualifier None = 14
  optional onsetQualifier None = 15
 }
// A substance intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease
message Drug
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated molecularlyInteractsWith None = 13
  repeated affectsAbundanceOf None = 14
  repeated increasesAbundanceOf None = 15
  repeated decreasesAbundanceOf None = 16
  repeated affectsActivityOf None = 17
  repeated increasesActivityOf None = 18
  repeated decreasesActivityOf None = 19
  repeated affectsExpressionOf None = 20
  repeated increasesExpressionOf None = 21
  repeated decreasesExpressionOf None = 22
  repeated affectsFoldingOf None = 23
  repeated increasesFoldingOf None = 24
  repeated decreasesFoldingOf None = 25
  repeated affectsLocalizationOf None = 26
  repeated increasesLocalizationOf None = 27
  repeated decreasesLocalizationOf None = 28
  repeated affectsMetabolicProcessingOf None = 29
  repeated increasesMetabolicProcessingOf None = 30
  repeated decreasesMetabolicProcessingOf None = 31
  repeated affectsMolecularModificationOf None = 32
  repeated increasesMolecularModificationOf None = 33
  repeated decreasesMolecularModificationOf None = 34
  repeated affectsSynthesisOf None = 35
  repeated increasesSynthesisOf None = 36
  repeated decreasesSynthesisOf None = 37
  repeated affectsDegradationOf None = 38
  repeated increasesDegradationOf None = 39
  repeated decreasesDegradationOf None = 40
  repeated affectsMutationRateOf None = 41
  repeated increasesMutationRateOf None = 42
  repeated decreasesMutationRateOf None = 43
  repeated affectsResponseTo None = 44
  repeated increasesResponseTo None = 45
  repeated decreasesResponseTo None = 46
  repeated affectsSplicingOf None = 47
  repeated increasesSplicingOf None = 48
  repeated decreasesSplicingOf None = 49
  repeated affectsStabilityOf None = 50
  repeated increasesStabilityOf None = 51
  repeated decreasesStabilityOf None = 52
  repeated affectsTransportOf None = 53
  repeated increasesTransportOf None = 54
  repeated decreasesTransportOf None = 55
  repeated affectsSecretionOf None = 56
  repeated increasesSecretionOf None = 57
  repeated decreasesSecretionOf None = 58
  repeated affectsUptakeOf None = 59
  repeated increasesUptakeOf None = 60
  repeated decreasesUptakeOf None = 61
  repeated regulatesEntityToEntity None = 62
  repeated biomarkerFor None = 63
  repeated inTaxon None = 64
 }
// A drug exposure is an intake of a particular chemical substance
message DrugExposure
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated drug None = 13
 }
// A feature of the environment of an organism that influences one or more phenotypic features of that organism, potentially mediated by genes
message Environment
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
 }
// Any association between an environment and a phenotypic feature, where being in the environment influences the phenotype
message EnvironmentToPhenotypicFeatureAssociation
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
  optional sexQualifier None = 12
  optional frequencyQualifier None = 13
  optional severityQualifier None = 14
  optional onsetQualifier None = 15
 }
message EnvironmentalFeature
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
 }
message EnvironmentalProcess
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated regulatesProcessToProcess None = 12
  repeated hasParticipant None = 13
  repeated hasInput None = 14
  repeated hasOutput None = 15
  repeated precedes None = 16
 }
// Class of evidence that supports an association
message EvidenceType
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
 }
// A region of the transcript sequence within a gene which is not removed from the primary RNA transcript by RNA splicing
message Exon
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated molecularlyInteractsWith None = 13
  repeated affectsAbundanceOf None = 14
  repeated increasesAbundanceOf None = 15
  repeated decreasesAbundanceOf None = 16
  repeated affectsActivityOf None = 17
  repeated increasesActivityOf None = 18
  repeated decreasesActivityOf None = 19
  repeated affectsExpressionOf None = 20
  repeated increasesExpressionOf None = 21
  repeated decreasesExpressionOf None = 22
  repeated affectsFoldingOf None = 23
  repeated increasesFoldingOf None = 24
  repeated decreasesFoldingOf None = 25
  repeated affectsLocalizationOf None = 26
  repeated increasesLocalizationOf None = 27
  repeated decreasesLocalizationOf None = 28
  repeated affectsMetabolicProcessingOf None = 29
  repeated increasesMetabolicProcessingOf None = 30
  repeated decreasesMetabolicProcessingOf None = 31
  repeated affectsMolecularModificationOf None = 32
  repeated increasesMolecularModificationOf None = 33
  repeated decreasesMolecularModificationOf None = 34
  repeated affectsSynthesisOf None = 35
  repeated increasesSynthesisOf None = 36
  repeated decreasesSynthesisOf None = 37
  repeated affectsDegradationOf None = 38
  repeated increasesDegradationOf None = 39
  repeated decreasesDegradationOf None = 40
  repeated affectsMutationRateOf None = 41
  repeated increasesMutationRateOf None = 42
  repeated decreasesMutationRateOf None = 43
  repeated affectsResponseTo None = 44
  repeated increasesResponseTo None = 45
  repeated decreasesResponseTo None = 46
  repeated affectsSplicingOf None = 47
  repeated increasesSplicingOf None = 48
  repeated decreasesSplicingOf None = 49
  repeated affectsStabilityOf None = 50
  repeated increasesStabilityOf None = 51
  repeated decreasesStabilityOf None = 52
  repeated affectsTransportOf None = 53
  repeated increasesTransportOf None = 54
  repeated decreasesTransportOf None = 55
  repeated affectsSecretionOf None = 56
  repeated increasesSecretionOf None = 57
  repeated decreasesSecretionOf None = 58
  repeated affectsUptakeOf None = 59
  repeated increasesUptakeOf None = 60
  repeated decreasesUptakeOf None = 61
  repeated regulatesEntityToEntity None = 62
  repeated biomarkerFor None = 63
  repeated inTaxon None = 64
  optional hasBiologicalSequence None = 65
 }
// A transcript is formed from multiple exons
message ExonToTranscriptRelationship
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
 }
// describes the frequency of occurrence of an event or condition
message FrequencyValue
 {
  optional hasAttributeType None = 1
  repeated hasQuantitativeValue None = 2
  optional hasQualitativeValue None = 3
  id None = 4
  name None = 5
  repeated category None = 6
  repeated relatedTo None = 7
  repeated interactsWith None = 8
  optional nodeProperty None = 9
  optional iri None = 10
  repeated synonym None = 11
  optional fullName None = 12
  optional description None = 13
  repeated systematicSynonym None = 14
  repeated subclassOf None = 15
 }
// An association between a macromolecular machine (gene, gene product or complex of gene products) and either a molecular activity, a biological process or a cellular location in which a function is executed
message FunctionalAssociation
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
 }
message Gene
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated molecularlyInteractsWith None = 13
  repeated affectsAbundanceOf None = 14
  repeated increasesAbundanceOf None = 15
  repeated decreasesAbundanceOf None = 16
  repeated affectsActivityOf None = 17
  repeated increasesActivityOf None = 18
  repeated decreasesActivityOf None = 19
  repeated affectsExpressionOf None = 20
  repeated increasesExpressionOf None = 21
  repeated decreasesExpressionOf None = 22
  repeated affectsFoldingOf None = 23
  repeated increasesFoldingOf None = 24
  repeated decreasesFoldingOf None = 25
  repeated affectsLocalizationOf None = 26
  repeated increasesLocalizationOf None = 27
  repeated decreasesLocalizationOf None = 28
  repeated affectsMetabolicProcessingOf None = 29
  repeated increasesMetabolicProcessingOf None = 30
  repeated decreasesMetabolicProcessingOf None = 31
  repeated affectsMolecularModificationOf None = 32
  repeated increasesMolecularModificationOf None = 33
  repeated decreasesMolecularModificationOf None = 34
  repeated affectsSynthesisOf None = 35
  repeated increasesSynthesisOf None = 36
  repeated decreasesSynthesisOf None = 37
  repeated affectsDegradationOf None = 38
  repeated increasesDegradationOf None = 39
  repeated decreasesDegradationOf None = 40
  repeated affectsMutationRateOf None = 41
  repeated increasesMutationRateOf None = 42
  repeated decreasesMutationRateOf None = 43
  repeated affectsResponseTo None = 44
  repeated increasesResponseTo None = 45
  repeated decreasesResponseTo None = 46
  repeated affectsSplicingOf None = 47
  repeated increasesSplicingOf None = 48
  repeated decreasesSplicingOf None = 49
  repeated affectsStabilityOf None = 50
  repeated increasesStabilityOf None = 51
  repeated decreasesStabilityOf None = 52
  repeated affectsTransportOf None = 53
  repeated increasesTransportOf None = 54
  repeated decreasesTransportOf None = 55
  repeated affectsSecretionOf None = 56
  repeated increasesSecretionOf None = 57
  repeated decreasesSecretionOf None = 58
  repeated affectsUptakeOf None = 59
  repeated increasesUptakeOf None = 60
  repeated decreasesUptakeOf None = 61
  repeated regulatesEntityToEntity None = 62
  repeated biomarkerFor None = 63
  repeated inTaxon None = 64
  optional hasBiologicalSequence None = 65
  repeated inPathwayWith None = 66
  repeated inComplexWith None = 67
  repeated inCellPopulationWith None = 68
  repeated expressedIn None = 69
  repeated geneticallyInteractsWith None = 70
  repeated hasGeneProduct None = 71
  repeated geneAssociatedWithCondition None = 72
 }
message GeneAsAModelOfDiseaseAssociation
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
  optional frequencyQualifier None = 12
  optional severityQualifier None = 13
  optional onsetQualifier None = 14
 }
// any grouping of multiple genes or gene products related by common descent
message GeneFamily
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated molecularlyInteractsWith None = 13
  repeated affectsAbundanceOf None = 14
  repeated increasesAbundanceOf None = 15
  repeated decreasesAbundanceOf None = 16
  repeated affectsActivityOf None = 17
  repeated increasesActivityOf None = 18
  repeated decreasesActivityOf None = 19
  repeated affectsExpressionOf None = 20
  repeated increasesExpressionOf None = 21
  repeated decreasesExpressionOf None = 22
  repeated affectsFoldingOf None = 23
  repeated increasesFoldingOf None = 24
  repeated decreasesFoldingOf None = 25
  repeated affectsLocalizationOf None = 26
  repeated increasesLocalizationOf None = 27
  repeated decreasesLocalizationOf None = 28
  repeated affectsMetabolicProcessingOf None = 29
  repeated increasesMetabolicProcessingOf None = 30
  repeated decreasesMetabolicProcessingOf None = 31
  repeated affectsMolecularModificationOf None = 32
  repeated increasesMolecularModificationOf None = 33
  repeated decreasesMolecularModificationOf None = 34
  repeated affectsSynthesisOf None = 35
  repeated increasesSynthesisOf None = 36
  repeated decreasesSynthesisOf None = 37
  repeated affectsDegradationOf None = 38
  repeated increasesDegradationOf None = 39
  repeated decreasesDegradationOf None = 40
  repeated affectsMutationRateOf None = 41
  repeated increasesMutationRateOf None = 42
  repeated decreasesMutationRateOf None = 43
  repeated affectsResponseTo None = 44
  repeated increasesResponseTo None = 45
  repeated decreasesResponseTo None = 46
  repeated affectsSplicingOf None = 47
  repeated increasesSplicingOf None = 48
  repeated decreasesSplicingOf None = 49
  repeated affectsStabilityOf None = 50
  repeated increasesStabilityOf None = 51
  repeated decreasesStabilityOf None = 52
  repeated affectsTransportOf None = 53
  repeated increasesTransportOf None = 54
  repeated decreasesTransportOf None = 55
  repeated affectsSecretionOf None = 56
  repeated increasesSecretionOf None = 57
  repeated decreasesSecretionOf None = 58
  repeated affectsUptakeOf None = 59
  repeated increasesUptakeOf None = 60
  repeated decreasesUptakeOf None = 61
  repeated regulatesEntityToEntity None = 62
  repeated biomarkerFor None = 63
  repeated inTaxon None = 64
 }
message GeneHasVariantThatContributesToDiseaseAssociation
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
  optional frequencyQualifier None = 12
  optional severityQualifier None = 13
  optional onsetQualifier None = 14
  optional sequenceVariantQualifier None = 15
 }
// an ontology class that describes a functional aspect of a gene, gene prodoct or complex
message GeneOntologyClass
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated subclassOf None = 12
 }
// a union of genes or gene products. Frequently an identifier for one will be used as proxy for another
message GeneOrGeneProduct
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated molecularlyInteractsWith None = 13
  repeated affectsAbundanceOf None = 14
  repeated increasesAbundanceOf None = 15
  repeated decreasesAbundanceOf None = 16
  repeated affectsActivityOf None = 17
  repeated increasesActivityOf None = 18
  repeated decreasesActivityOf None = 19
  repeated affectsExpressionOf None = 20
  repeated increasesExpressionOf None = 21
  repeated decreasesExpressionOf None = 22
  repeated affectsFoldingOf None = 23
  repeated increasesFoldingOf None = 24
  repeated decreasesFoldingOf None = 25
  repeated affectsLocalizationOf None = 26
  repeated increasesLocalizationOf None = 27
  repeated decreasesLocalizationOf None = 28
  repeated affectsMetabolicProcessingOf None = 29
  repeated increasesMetabolicProcessingOf None = 30
  repeated decreasesMetabolicProcessingOf None = 31
  repeated affectsMolecularModificationOf None = 32
  repeated increasesMolecularModificationOf None = 33
  repeated decreasesMolecularModificationOf None = 34
  repeated affectsSynthesisOf None = 35
  repeated increasesSynthesisOf None = 36
  repeated decreasesSynthesisOf None = 37
  repeated affectsDegradationOf None = 38
  repeated increasesDegradationOf None = 39
  repeated decreasesDegradationOf None = 40
  repeated affectsMutationRateOf None = 41
  repeated increasesMutationRateOf None = 42
  repeated decreasesMutationRateOf None = 43
  repeated affectsResponseTo None = 44
  repeated increasesResponseTo None = 45
  repeated decreasesResponseTo None = 46
  repeated affectsSplicingOf None = 47
  repeated increasesSplicingOf None = 48
  repeated decreasesSplicingOf None = 49
  repeated affectsStabilityOf None = 50
  repeated increasesStabilityOf None = 51
  repeated decreasesStabilityOf None = 52
  repeated affectsTransportOf None = 53
  repeated increasesTransportOf None = 54
  repeated decreasesTransportOf None = 55
  repeated affectsSecretionOf None = 56
  repeated increasesSecretionOf None = 57
  repeated decreasesSecretionOf None = 58
  repeated affectsUptakeOf None = 59
  repeated increasesUptakeOf None = 60
  repeated decreasesUptakeOf None = 61
  repeated regulatesEntityToEntity None = 62
  repeated biomarkerFor None = 63
  repeated inTaxon None = 64
  optional hasBiologicalSequence None = 65
  repeated inPathwayWith None = 66
  repeated inComplexWith None = 67
  repeated inCellPopulationWith None = 68
  repeated expressedIn None = 69
 }
// The functional molecular product of a single gene. Gene products are either proteins or functional RNA molecules
message GeneProduct
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated molecularlyInteractsWith None = 13
  repeated affectsAbundanceOf None = 14
  repeated increasesAbundanceOf None = 15
  repeated decreasesAbundanceOf None = 16
  repeated affectsActivityOf None = 17
  repeated increasesActivityOf None = 18
  repeated decreasesActivityOf None = 19
  repeated affectsExpressionOf None = 20
  repeated increasesExpressionOf None = 21
  repeated decreasesExpressionOf None = 22
  repeated affectsFoldingOf None = 23
  repeated increasesFoldingOf None = 24
  repeated decreasesFoldingOf None = 25
  repeated affectsLocalizationOf None = 26
  repeated increasesLocalizationOf None = 27
  repeated decreasesLocalizationOf None = 28
  repeated affectsMetabolicProcessingOf None = 29
  repeated increasesMetabolicProcessingOf None = 30
  repeated decreasesMetabolicProcessingOf None = 31
  repeated affectsMolecularModificationOf None = 32
  repeated increasesMolecularModificationOf None = 33
  repeated decreasesMolecularModificationOf None = 34
  repeated affectsSynthesisOf None = 35
  repeated increasesSynthesisOf None = 36
  repeated decreasesSynthesisOf None = 37
  repeated affectsDegradationOf None = 38
  repeated increasesDegradationOf None = 39
  repeated decreasesDegradationOf None = 40
  repeated affectsMutationRateOf None = 41
  repeated increasesMutationRateOf None = 42
  repeated decreasesMutationRateOf None = 43
  repeated affectsResponseTo None = 44
  repeated increasesResponseTo None = 45
  repeated decreasesResponseTo None = 46
  repeated affectsSplicingOf None = 47
  repeated increasesSplicingOf None = 48
  repeated decreasesSplicingOf None = 49
  repeated affectsStabilityOf None = 50
  repeated increasesStabilityOf None = 51
  repeated decreasesStabilityOf None = 52
  repeated affectsTransportOf None = 53
  repeated increasesTransportOf None = 54
  repeated decreasesTransportOf None = 55
  repeated affectsSecretionOf None = 56
  repeated increasesSecretionOf None = 57
  repeated decreasesSecretionOf None = 58
  repeated affectsUptakeOf None = 59
  repeated increasesUptakeOf None = 60
  repeated decreasesUptakeOf None = 61
  repeated regulatesEntityToEntity None = 62
  repeated biomarkerFor None = 63
  repeated inTaxon None = 64
  optional hasBiologicalSequence None = 65
  repeated inPathwayWith None = 66
  repeated inComplexWith None = 67
  repeated inCellPopulationWith None = 68
  repeated expressedIn None = 69
 }
// A regulatory relationship between two genes
message GeneRegulatoryRelationship
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
 }
message GeneToDiseaseAssociation
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
  optional frequencyQualifier None = 12
  optional severityQualifier None = 13
  optional onsetQualifier None = 14
 }
// An association between a gene and an expression site, possibly qualified by stage/timing info.
message GeneToExpressionSiteAssociation
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
  optional stageQualifier None = 12
  optional quantifierQualifier None = 13
 }
// A homology association between two genes. May be orthology (in which case the species of subject and object should differ) or paralogy (in which case the species may be the same)
message GeneToGeneHomologyAssociation
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
 }
// A gene is transcribed and potentially translated to a gene product
message GeneToGeneProductRelationship
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
 }
message GeneToGoTermAssociation
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
 }
message GeneToPhenotypicFeatureAssociation
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
  optional sexQualifier None = 12
  optional frequencyQualifier None = 13
  optional severityQualifier None = 14
  optional onsetQualifier None = 15
 }
// A genome is the sum of genetic material within a cell or virion.
message Genome
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated molecularlyInteractsWith None = 13
  repeated affectsAbundanceOf None = 14
  repeated increasesAbundanceOf None = 15
  repeated decreasesAbundanceOf None = 16
  repeated affectsActivityOf None = 17
  repeated increasesActivityOf None = 18
  repeated decreasesActivityOf None = 19
  repeated affectsExpressionOf None = 20
  repeated increasesExpressionOf None = 21
  repeated decreasesExpressionOf None = 22
  repeated affectsFoldingOf None = 23
  repeated increasesFoldingOf None = 24
  repeated decreasesFoldingOf None = 25
  repeated affectsLocalizationOf None = 26
  repeated increasesLocalizationOf None = 27
  repeated decreasesLocalizationOf None = 28
  repeated affectsMetabolicProcessingOf None = 29
  repeated increasesMetabolicProcessingOf None = 30
  repeated decreasesMetabolicProcessingOf None = 31
  repeated affectsMolecularModificationOf None = 32
  repeated increasesMolecularModificationOf None = 33
  repeated decreasesMolecularModificationOf None = 34
  repeated affectsSynthesisOf None = 35
  repeated increasesSynthesisOf None = 36
  repeated decreasesSynthesisOf None = 37
  repeated affectsDegradationOf None = 38
  repeated increasesDegradationOf None = 39
  repeated decreasesDegradationOf None = 40
  repeated affectsMutationRateOf None = 41
  repeated increasesMutationRateOf None = 42
  repeated decreasesMutationRateOf None = 43
  repeated affectsResponseTo None = 44
  repeated increasesResponseTo None = 45
  repeated decreasesResponseTo None = 46
  repeated affectsSplicingOf None = 47
  repeated increasesSplicingOf None = 48
  repeated decreasesSplicingOf None = 49
  repeated affectsStabilityOf None = 50
  repeated increasesStabilityOf None = 51
  repeated decreasesStabilityOf None = 52
  repeated affectsTransportOf None = 53
  repeated increasesTransportOf None = 54
  repeated decreasesTransportOf None = 55
  repeated affectsSecretionOf None = 56
  repeated increasesSecretionOf None = 57
  repeated decreasesSecretionOf None = 58
  repeated affectsUptakeOf None = 59
  repeated increasesUptakeOf None = 60
  repeated decreasesUptakeOf None = 61
  repeated regulatesEntityToEntity None = 62
  repeated biomarkerFor None = 63
  repeated inTaxon None = 64
  optional hasBiologicalSequence None = 65
 }
// an entity that can either be directly located on a genome (gene, transcript, exon, regulatory region) or is encoded in a genome (protein)
message GenomicEntity
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated molecularlyInteractsWith None = 13
  repeated affectsAbundanceOf None = 14
  repeated increasesAbundanceOf None = 15
  repeated decreasesAbundanceOf None = 16
  repeated affectsActivityOf None = 17
  repeated increasesActivityOf None = 18
  repeated decreasesActivityOf None = 19
  repeated affectsExpressionOf None = 20
  repeated increasesExpressionOf None = 21
  repeated decreasesExpressionOf None = 22
  repeated affectsFoldingOf None = 23
  repeated increasesFoldingOf None = 24
  repeated decreasesFoldingOf None = 25
  repeated affectsLocalizationOf None = 26
  repeated increasesLocalizationOf None = 27
  repeated decreasesLocalizationOf None = 28
  repeated affectsMetabolicProcessingOf None = 29
  repeated increasesMetabolicProcessingOf None = 30
  repeated decreasesMetabolicProcessingOf None = 31
  repeated affectsMolecularModificationOf None = 32
  repeated increasesMolecularModificationOf None = 33
  repeated decreasesMolecularModificationOf None = 34
  repeated affectsSynthesisOf None = 35
  repeated increasesSynthesisOf None = 36
  repeated decreasesSynthesisOf None = 37
  repeated affectsDegradationOf None = 38
  repeated increasesDegradationOf None = 39
  repeated decreasesDegradationOf None = 40
  repeated affectsMutationRateOf None = 41
  repeated increasesMutationRateOf None = 42
  repeated decreasesMutationRateOf None = 43
  repeated affectsResponseTo None = 44
  repeated increasesResponseTo None = 45
  repeated decreasesResponseTo None = 46
  repeated affectsSplicingOf None = 47
  repeated increasesSplicingOf None = 48
  repeated decreasesSplicingOf None = 49
  repeated affectsStabilityOf None = 50
  repeated increasesStabilityOf None = 51
  repeated decreasesStabilityOf None = 52
  repeated affectsTransportOf None = 53
  repeated increasesTransportOf None = 54
  repeated decreasesTransportOf None = 55
  repeated affectsSecretionOf None = 56
  repeated increasesSecretionOf None = 57
  repeated decreasesSecretionOf None = 58
  repeated affectsUptakeOf None = 59
  repeated increasesUptakeOf None = 60
  repeated decreasesUptakeOf None = 61
  repeated regulatesEntityToEntity None = 62
  repeated biomarkerFor None = 63
  repeated inTaxon None = 64
  optional hasBiologicalSequence None = 65
 }
// A relationship between a sequence feature and an entity it is localized to. The reference entity may be a chromosome, chromosome region or information entity such as a contig
message GenomicSequenceLocalization
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
  optional startInterbaseCoordinate None = 12
  optional endInterbaseCoordinate None = 13
  optional genomeBuild None = 14
  optional phase None = 15
 }
// An information content entity that describes a genome by specifying the total variation in genomic sequence and/or gene expression, relative to some extablished background
message Genotype
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated molecularlyInteractsWith None = 13
  repeated affectsAbundanceOf None = 14
  repeated increasesAbundanceOf None = 15
  repeated decreasesAbundanceOf None = 16
  repeated affectsActivityOf None = 17
  repeated increasesActivityOf None = 18
  repeated decreasesActivityOf None = 19
  repeated affectsExpressionOf None = 20
  repeated increasesExpressionOf None = 21
  repeated decreasesExpressionOf None = 22
  repeated affectsFoldingOf None = 23
  repeated increasesFoldingOf None = 24
  repeated decreasesFoldingOf None = 25
  repeated affectsLocalizationOf None = 26
  repeated increasesLocalizationOf None = 27
  repeated decreasesLocalizationOf None = 28
  repeated affectsMetabolicProcessingOf None = 29
  repeated increasesMetabolicProcessingOf None = 30
  repeated decreasesMetabolicProcessingOf None = 31
  repeated affectsMolecularModificationOf None = 32
  repeated increasesMolecularModificationOf None = 33
  repeated decreasesMolecularModificationOf None = 34
  repeated affectsSynthesisOf None = 35
  repeated increasesSynthesisOf None = 36
  repeated decreasesSynthesisOf None = 37
  repeated affectsDegradationOf None = 38
  repeated increasesDegradationOf None = 39
  repeated decreasesDegradationOf None = 40
  repeated affectsMutationRateOf None = 41
  repeated increasesMutationRateOf None = 42
  repeated decreasesMutationRateOf None = 43
  repeated affectsResponseTo None = 44
  repeated increasesResponseTo None = 45
  repeated decreasesResponseTo None = 46
  repeated affectsSplicingOf None = 47
  repeated increasesSplicingOf None = 48
  repeated decreasesSplicingOf None = 49
  repeated affectsStabilityOf None = 50
  repeated increasesStabilityOf None = 51
  repeated decreasesStabilityOf None = 52
  repeated affectsTransportOf None = 53
  repeated increasesTransportOf None = 54
  repeated decreasesTransportOf None = 55
  repeated affectsSecretionOf None = 56
  repeated increasesSecretionOf None = 57
  repeated decreasesSecretionOf None = 58
  repeated affectsUptakeOf None = 59
  repeated increasesUptakeOf None = 60
  repeated decreasesUptakeOf None = 61
  repeated regulatesEntityToEntity None = 62
  repeated biomarkerFor None = 63
  repeated inTaxon None = 64
  optional hasBiologicalSequence None = 65
  optional hasZygosity None = 66
 }
// Any association between a genotype and a gene. The genotype have have multiple variants in that gene or a single one. There is no assumption of cardinality
message GenotypeToGeneAssociation
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
 }
// Any association between one genotype and a genotypic entity that is a sub-component of it
message GenotypeToGenotypePartAssociation
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
 }
// Any association between one genotype and a phenotypic feature, where having the genotype confers the phenotype, either in isolation or through environment
message GenotypeToPhenotypicFeatureAssociation
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
  optional sexQualifier None = 12
  optional frequencyQualifier None = 13
  optional severityQualifier None = 14
  optional onsetQualifier None = 15
 }
// Any association between a genotype and a sequence variant.
message GenotypeToVariantAssociation
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
 }
// An attribute corresponding to the genotypic sex of the individual, based upon genotypic composition of sex chromosomes.
message GenotypicSex
 {
  optional hasAttributeType None = 1
  repeated hasQuantitativeValue None = 2
  optional hasQualitativeValue None = 3
  id None = 4
  name None = 5
  repeated category None = 6
  repeated relatedTo None = 7
  repeated interactsWith None = 8
  optional nodeProperty None = 9
  optional iri None = 10
  repeated synonym None = 11
  optional fullName None = 12
  optional description None = 13
  repeated systematicSynonym None = 14
  repeated subclassOf None = 15
 }
// a location that can be described in lat/long coordinates
message GeographicLocation
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  optional latitude None = 12
  optional longitude None = 13
 }
// a location that can be described in lat/long coordinates, for a particular time
message GeographicLocationAtTime
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  optional latitude None = 12
  optional longitude None = 13
  optional timepoint None = 14
 }
message GrossAnatomicalStructure
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated expresses None = 13
  repeated inTaxon None = 14
 }
// A set of zero or more Alleles on a single instance of a Sequence[VMC]
message Haplotype
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated molecularlyInteractsWith None = 13
  repeated affectsAbundanceOf None = 14
  repeated increasesAbundanceOf None = 15
  repeated decreasesAbundanceOf None = 16
  repeated affectsActivityOf None = 17
  repeated increasesActivityOf None = 18
  repeated decreasesActivityOf None = 19
  repeated affectsExpressionOf None = 20
  repeated increasesExpressionOf None = 21
  repeated decreasesExpressionOf None = 22
  repeated affectsFoldingOf None = 23
  repeated increasesFoldingOf None = 24
  repeated decreasesFoldingOf None = 25
  repeated affectsLocalizationOf None = 26
  repeated increasesLocalizationOf None = 27
  repeated decreasesLocalizationOf None = 28
  repeated affectsMetabolicProcessingOf None = 29
  repeated increasesMetabolicProcessingOf None = 30
  repeated decreasesMetabolicProcessingOf None = 31
  repeated affectsMolecularModificationOf None = 32
  repeated increasesMolecularModificationOf None = 33
  repeated decreasesMolecularModificationOf None = 34
  repeated affectsSynthesisOf None = 35
  repeated increasesSynthesisOf None = 36
  repeated decreasesSynthesisOf None = 37
  repeated affectsDegradationOf None = 38
  repeated increasesDegradationOf None = 39
  repeated decreasesDegradationOf None = 40
  repeated affectsMutationRateOf None = 41
  repeated increasesMutationRateOf None = 42
  repeated decreasesMutationRateOf None = 43
  repeated affectsResponseTo None = 44
  repeated increasesResponseTo None = 45
  repeated decreasesResponseTo None = 46
  repeated affectsSplicingOf None = 47
  repeated increasesSplicingOf None = 48
  repeated decreasesSplicingOf None = 49
  repeated affectsStabilityOf None = 50
  repeated increasesStabilityOf None = 51
  repeated decreasesStabilityOf None = 52
  repeated affectsTransportOf None = 53
  repeated increasesTransportOf None = 54
  repeated decreasesTransportOf None = 55
  repeated affectsSecretionOf None = 56
  repeated increasesSecretionOf None = 57
  repeated decreasesSecretionOf None = 58
  repeated affectsUptakeOf None = 59
  repeated increasesUptakeOf None = 60
  repeated decreasesUptakeOf None = 61
  repeated regulatesEntityToEntity None = 62
  repeated biomarkerFor None = 63
  repeated inTaxon None = 64
  optional hasBiologicalSequence None = 65
 }
message IndividualOrganism
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated inTaxon None = 13
 }
// A stage of development or growth of an organism, including post-natal adult stages
message LifeStage
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated inTaxon None = 13
 }
message MacromolecularComplex
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated molecularlyInteractsWith None = 13
  repeated affectsAbundanceOf None = 14
  repeated increasesAbundanceOf None = 15
  repeated decreasesAbundanceOf None = 16
  repeated affectsActivityOf None = 17
  repeated increasesActivityOf None = 18
  repeated decreasesActivityOf None = 19
  repeated affectsExpressionOf None = 20
  repeated increasesExpressionOf None = 21
  repeated decreasesExpressionOf None = 22
  repeated affectsFoldingOf None = 23
  repeated increasesFoldingOf None = 24
  repeated decreasesFoldingOf None = 25
  repeated affectsLocalizationOf None = 26
  repeated increasesLocalizationOf None = 27
  repeated decreasesLocalizationOf None = 28
  repeated affectsMetabolicProcessingOf None = 29
  repeated increasesMetabolicProcessingOf None = 30
  repeated decreasesMetabolicProcessingOf None = 31
  repeated affectsMolecularModificationOf None = 32
  repeated increasesMolecularModificationOf None = 33
  repeated decreasesMolecularModificationOf None = 34
  repeated affectsSynthesisOf None = 35
  repeated increasesSynthesisOf None = 36
  repeated decreasesSynthesisOf None = 37
  repeated affectsDegradationOf None = 38
  repeated increasesDegradationOf None = 39
  repeated decreasesDegradationOf None = 40
  repeated affectsMutationRateOf None = 41
  repeated increasesMutationRateOf None = 42
  repeated decreasesMutationRateOf None = 43
  repeated affectsResponseTo None = 44
  repeated increasesResponseTo None = 45
  repeated decreasesResponseTo None = 46
  repeated affectsSplicingOf None = 47
  repeated increasesSplicingOf None = 48
  repeated decreasesSplicingOf None = 49
  repeated affectsStabilityOf None = 50
  repeated increasesStabilityOf None = 51
  repeated decreasesStabilityOf None = 52
  repeated affectsTransportOf None = 53
  repeated increasesTransportOf None = 54
  repeated decreasesTransportOf None = 55
  repeated affectsSecretionOf None = 56
  repeated increasesSecretionOf None = 57
  repeated decreasesSecretionOf None = 58
  repeated affectsUptakeOf None = 59
  repeated increasesUptakeOf None = 60
  repeated decreasesUptakeOf None = 61
  repeated regulatesEntityToEntity None = 62
  repeated biomarkerFor None = 63
  repeated inTaxon None = 64
  optional hasBiologicalSequence None = 65
 }
// A union of gene, gene product, and macromolecular complex. These are the basic units of function in a cell. They either carry out individual biological activities, or they encode molecules which do this.
message MacromolecularMachine
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated molecularlyInteractsWith None = 13
  repeated affectsAbundanceOf None = 14
  repeated increasesAbundanceOf None = 15
  repeated decreasesAbundanceOf None = 16
  repeated affectsActivityOf None = 17
  repeated increasesActivityOf None = 18
  repeated decreasesActivityOf None = 19
  repeated affectsExpressionOf None = 20
  repeated increasesExpressionOf None = 21
  repeated decreasesExpressionOf None = 22
  repeated affectsFoldingOf None = 23
  repeated increasesFoldingOf None = 24
  repeated decreasesFoldingOf None = 25
  repeated affectsLocalizationOf None = 26
  repeated increasesLocalizationOf None = 27
  repeated decreasesLocalizationOf None = 28
  repeated affectsMetabolicProcessingOf None = 29
  repeated increasesMetabolicProcessingOf None = 30
  repeated decreasesMetabolicProcessingOf None = 31
  repeated affectsMolecularModificationOf None = 32
  repeated increasesMolecularModificationOf None = 33
  repeated decreasesMolecularModificationOf None = 34
  repeated affectsSynthesisOf None = 35
  repeated increasesSynthesisOf None = 36
  repeated decreasesSynthesisOf None = 37
  repeated affectsDegradationOf None = 38
  repeated increasesDegradationOf None = 39
  repeated decreasesDegradationOf None = 40
  repeated affectsMutationRateOf None = 41
  repeated increasesMutationRateOf None = 42
  repeated decreasesMutationRateOf None = 43
  repeated affectsResponseTo None = 44
  repeated increasesResponseTo None = 45
  repeated decreasesResponseTo None = 46
  repeated affectsSplicingOf None = 47
  repeated increasesSplicingOf None = 48
  repeated decreasesSplicingOf None = 49
  repeated affectsStabilityOf None = 50
  repeated increasesStabilityOf None = 51
  repeated decreasesStabilityOf None = 52
  repeated affectsTransportOf None = 53
  repeated increasesTransportOf None = 54
  repeated decreasesTransportOf None = 55
  repeated affectsSecretionOf None = 56
  repeated increasesSecretionOf None = 57
  repeated decreasesSecretionOf None = 58
  repeated affectsUptakeOf None = 59
  repeated increasesUptakeOf None = 60
  repeated decreasesUptakeOf None = 61
  repeated regulatesEntityToEntity None = 62
  repeated biomarkerFor None = 63
  repeated inTaxon None = 64
  optional hasBiologicalSequence None = 65
 }
// A functional association between a macromolecular machine (gene, gene product or complex) and a biological process or pathway (as represented in the GO biological process branch), where the entity carries out some part of the process, regulates it, or acts upstream of it
message MacromolecularMachineToBiologicalProcessAssociation
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
 }
// A functional association between a macromolecular machine (gene, gene product or complex) and a cellular component (as represented in the GO cellular component branch), where the entity carries out its function in the cellular component
message MacromolecularMachineToCellularComponentAssociation
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
 }
// A functional association between a macromolecular machine (gene, gene product or complex) and a molecular activity (as represented in the GO molecular function branch), where the entity carries out the activity, or contributes to its execution
message MacromolecularMachineToMolecularActivityAssociation
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
 }
// A sample is a limited quantity of something (e.g. an individual or set of individuals from a population, or a portion of a substance) to be used for testing, analysis, inspection, investigation, demonstration, or trial use. [SIO]
message MaterialSample
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasAttribute None = 12
 }
// An association between a material sample and the material entity it is derived from
message MaterialSampleDerivationAssociation
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
 }
// An association between a material sample and a disease or phenotype
message MaterialSampleToDiseaseOrPhenotypicFeatureAssociation
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
 }
// Any intermediate or product resulting from metabolism. Includes primary and secondary metabolites.
message Metabolite
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated molecularlyInteractsWith None = 13
  repeated affectsAbundanceOf None = 14
  repeated increasesAbundanceOf None = 15
  repeated decreasesAbundanceOf None = 16
  repeated affectsActivityOf None = 17
  repeated increasesActivityOf None = 18
  repeated decreasesActivityOf None = 19
  repeated affectsExpressionOf None = 20
  repeated increasesExpressionOf None = 21
  repeated decreasesExpressionOf None = 22
  repeated affectsFoldingOf None = 23
  repeated increasesFoldingOf None = 24
  repeated decreasesFoldingOf None = 25
  repeated affectsLocalizationOf None = 26
  repeated increasesLocalizationOf None = 27
  repeated decreasesLocalizationOf None = 28
  repeated affectsMetabolicProcessingOf None = 29
  repeated increasesMetabolicProcessingOf None = 30
  repeated decreasesMetabolicProcessingOf None = 31
  repeated affectsMolecularModificationOf None = 32
  repeated increasesMolecularModificationOf None = 33
  repeated decreasesMolecularModificationOf None = 34
  repeated affectsSynthesisOf None = 35
  repeated increasesSynthesisOf None = 36
  repeated decreasesSynthesisOf None = 37
  repeated affectsDegradationOf None = 38
  repeated increasesDegradationOf None = 39
  repeated decreasesDegradationOf None = 40
  repeated affectsMutationRateOf None = 41
  repeated increasesMutationRateOf None = 42
  repeated decreasesMutationRateOf None = 43
  repeated affectsResponseTo None = 44
  repeated increasesResponseTo None = 45
  repeated decreasesResponseTo None = 46
  repeated affectsSplicingOf None = 47
  repeated increasesSplicingOf None = 48
  repeated decreasesSplicingOf None = 49
  repeated affectsStabilityOf None = 50
  repeated increasesStabilityOf None = 51
  repeated decreasesStabilityOf None = 52
  repeated affectsTransportOf None = 53
  repeated increasesTransportOf None = 54
  repeated decreasesTransportOf None = 55
  repeated affectsSecretionOf None = 56
  repeated increasesSecretionOf None = 57
  repeated decreasesSecretionOf None = 58
  repeated affectsUptakeOf None = 59
  repeated increasesUptakeOf None = 60
  repeated decreasesUptakeOf None = 61
  repeated regulatesEntityToEntity None = 62
  repeated biomarkerFor None = 63
  repeated inTaxon None = 64
 }
message MicroRNA
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated molecularlyInteractsWith None = 13
  repeated affectsAbundanceOf None = 14
  repeated increasesAbundanceOf None = 15
  repeated decreasesAbundanceOf None = 16
  repeated affectsActivityOf None = 17
  repeated increasesActivityOf None = 18
  repeated decreasesActivityOf None = 19
  repeated affectsExpressionOf None = 20
  repeated increasesExpressionOf None = 21
  repeated decreasesExpressionOf None = 22
  repeated affectsFoldingOf None = 23
  repeated increasesFoldingOf None = 24
  repeated decreasesFoldingOf None = 25
  repeated affectsLocalizationOf None = 26
  repeated increasesLocalizationOf None = 27
  repeated decreasesLocalizationOf None = 28
  repeated affectsMetabolicProcessingOf None = 29
  repeated increasesMetabolicProcessingOf None = 30
  repeated decreasesMetabolicProcessingOf None = 31
  repeated affectsMolecularModificationOf None = 32
  repeated increasesMolecularModificationOf None = 33
  repeated decreasesMolecularModificationOf None = 34
  repeated affectsSynthesisOf None = 35
  repeated increasesSynthesisOf None = 36
  repeated decreasesSynthesisOf None = 37
  repeated affectsDegradationOf None = 38
  repeated increasesDegradationOf None = 39
  repeated decreasesDegradationOf None = 40
  repeated affectsMutationRateOf None = 41
  repeated increasesMutationRateOf None = 42
  repeated decreasesMutationRateOf None = 43
  repeated affectsResponseTo None = 44
  repeated increasesResponseTo None = 45
  repeated decreasesResponseTo None = 46
  repeated affectsSplicingOf None = 47
  repeated increasesSplicingOf None = 48
  repeated decreasesSplicingOf None = 49
  repeated affectsStabilityOf None = 50
  repeated increasesStabilityOf None = 51
  repeated decreasesStabilityOf None = 52
  repeated affectsTransportOf None = 53
  repeated increasesTransportOf None = 54
  repeated decreasesTransportOf None = 55
  repeated affectsSecretionOf None = 56
  repeated increasesSecretionOf None = 57
  repeated decreasesSecretionOf None = 58
  repeated affectsUptakeOf None = 59
  repeated increasesUptakeOf None = 60
  repeated decreasesUptakeOf None = 61
  repeated regulatesEntityToEntity None = 62
  repeated biomarkerFor None = 63
  repeated inTaxon None = 64
  optional hasBiologicalSequence None = 65
  repeated inPathwayWith None = 66
  repeated inComplexWith None = 67
  repeated inCellPopulationWith None = 68
  repeated expressedIn None = 69
 }
// An execution of a molecular function carried out by a gene product or macromolecular complex.
message MolecularActivity
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated hasInput None = 13
  repeated hasOutput None = 14
  repeated enabledBy None = 15
  repeated regulatesProcessToProcess None = 16
  repeated hasParticipant None = 17
  repeated precedes None = 18
 }
// A gene, gene product, small molecule or macromolecule (including protein complex)
message MolecularEntity
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated molecularlyInteractsWith None = 13
  repeated affectsAbundanceOf None = 14
  repeated increasesAbundanceOf None = 15
  repeated decreasesAbundanceOf None = 16
  repeated affectsActivityOf None = 17
  repeated increasesActivityOf None = 18
  repeated decreasesActivityOf None = 19
  repeated affectsExpressionOf None = 20
  repeated increasesExpressionOf None = 21
  repeated decreasesExpressionOf None = 22
  repeated affectsFoldingOf None = 23
  repeated increasesFoldingOf None = 24
  repeated decreasesFoldingOf None = 25
  repeated affectsLocalizationOf None = 26
  repeated increasesLocalizationOf None = 27
  repeated decreasesLocalizationOf None = 28
  repeated affectsMetabolicProcessingOf None = 29
  repeated increasesMetabolicProcessingOf None = 30
  repeated decreasesMetabolicProcessingOf None = 31
  repeated affectsMolecularModificationOf None = 32
  repeated increasesMolecularModificationOf None = 33
  repeated decreasesMolecularModificationOf None = 34
  repeated affectsSynthesisOf None = 35
  repeated increasesSynthesisOf None = 36
  repeated decreasesSynthesisOf None = 37
  repeated affectsDegradationOf None = 38
  repeated increasesDegradationOf None = 39
  repeated decreasesDegradationOf None = 40
  repeated affectsMutationRateOf None = 41
  repeated increasesMutationRateOf None = 42
  repeated decreasesMutationRateOf None = 43
  repeated affectsResponseTo None = 44
  repeated increasesResponseTo None = 45
  repeated decreasesResponseTo None = 46
  repeated affectsSplicingOf None = 47
  repeated increasesSplicingOf None = 48
  repeated decreasesSplicingOf None = 49
  repeated affectsStabilityOf None = 50
  repeated increasesStabilityOf None = 51
  repeated decreasesStabilityOf None = 52
  repeated affectsTransportOf None = 53
  repeated increasesTransportOf None = 54
  repeated decreasesTransportOf None = 55
  repeated affectsSecretionOf None = 56
  repeated increasesSecretionOf None = 57
  repeated decreasesSecretionOf None = 58
  repeated affectsUptakeOf None = 59
  repeated increasesUptakeOf None = 60
  repeated decreasesUptakeOf None = 61
  repeated regulatesEntityToEntity None = 62
  repeated biomarkerFor None = 63
  repeated inTaxon None = 64
  repeated positivelyRegulatesEntityToEntity None = 65
  repeated negativelyRegulatesEntityToEntity None = 66
 }
// a databased entity or concept/class
message NamedThing
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated physicallyInteractsWith None = 12
  repeated affects None = 13
  repeated regulates None = 14
  repeated positivelyRegulates None = 15
  repeated negativelyRegulates None = 16
  repeated disrupts None = 17
  repeated homologousTo None = 18
  repeated paralogousTo None = 19
  repeated orthologousTo None = 20
  repeated xenologousTo None = 21
  repeated coexistsWith None = 22
  repeated colocalizesWith None = 23
  repeated affectsRiskFor None = 24
  repeated predisposes None = 25
  repeated contributesTo None = 26
  repeated causes None = 27
  repeated prevents None = 28
  repeated occursIn None = 29
  repeated locatedIn None = 30
  repeated locationOf None = 31
  repeated modelOf None = 32
  repeated overlaps None = 33
  repeated hasPart None = 34
  repeated partOf None = 35
  repeated participatesIn None = 36
  repeated activelyInvolvedIn None = 37
  repeated capableOf None = 38
  repeated derivesInto None = 39
  repeated derivesFrom None = 40
  repeated manifestationOf None = 41
  repeated produces None = 42
  repeated sameAs None = 43
  optional type None = 44
  optional creationDate None = 45
  optional updateDate None = 46
  optional latitude None = 47
  optional longitude None = 48
  optional hasChemicalFormula None = 49
  optional aggregateStatistic None = 50
  optional hasCount None = 51
  optional hasTotal None = 52
  optional hasQuotient None = 53
  optional hasPercentage None = 54
  optional timepoint None = 55
  optional hasBiologicalSequence None = 56
  repeated hasMolecularConsequence None = 57
  optional hasGene None = 58
  optional hasZygosity None = 59
  optional filler None = 60
  optional phase None = 61
  optional genomeBuild None = 62
  optional interbaseCoordinate None = 63
  optional startInterbaseCoordinate None = 64
  optional endInterbaseCoordinate None = 65
 }
message NoncodingRNAProduct
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated molecularlyInteractsWith None = 13
  repeated affectsAbundanceOf None = 14
  repeated increasesAbundanceOf None = 15
  repeated decreasesAbundanceOf None = 16
  repeated affectsActivityOf None = 17
  repeated increasesActivityOf None = 18
  repeated decreasesActivityOf None = 19
  repeated affectsExpressionOf None = 20
  repeated increasesExpressionOf None = 21
  repeated decreasesExpressionOf None = 22
  repeated affectsFoldingOf None = 23
  repeated increasesFoldingOf None = 24
  repeated decreasesFoldingOf None = 25
  repeated affectsLocalizationOf None = 26
  repeated increasesLocalizationOf None = 27
  repeated decreasesLocalizationOf None = 28
  repeated affectsMetabolicProcessingOf None = 29
  repeated increasesMetabolicProcessingOf None = 30
  repeated decreasesMetabolicProcessingOf None = 31
  repeated affectsMolecularModificationOf None = 32
  repeated increasesMolecularModificationOf None = 33
  repeated decreasesMolecularModificationOf None = 34
  repeated affectsSynthesisOf None = 35
  repeated increasesSynthesisOf None = 36
  repeated decreasesSynthesisOf None = 37
  repeated affectsDegradationOf None = 38
  repeated increasesDegradationOf None = 39
  repeated decreasesDegradationOf None = 40
  repeated affectsMutationRateOf None = 41
  repeated increasesMutationRateOf None = 42
  repeated decreasesMutationRateOf None = 43
  repeated affectsResponseTo None = 44
  repeated increasesResponseTo None = 45
  repeated decreasesResponseTo None = 46
  repeated affectsSplicingOf None = 47
  repeated increasesSplicingOf None = 48
  repeated decreasesSplicingOf None = 49
  repeated affectsStabilityOf None = 50
  repeated increasesStabilityOf None = 51
  repeated decreasesStabilityOf None = 52
  repeated affectsTransportOf None = 53
  repeated increasesTransportOf None = 54
  repeated decreasesTransportOf None = 55
  repeated affectsSecretionOf None = 56
  repeated increasesSecretionOf None = 57
  repeated decreasesSecretionOf None = 58
  repeated affectsUptakeOf None = 59
  repeated increasesUptakeOf None = 60
  repeated decreasesUptakeOf None = 61
  repeated regulatesEntityToEntity None = 62
  repeated biomarkerFor None = 63
  repeated inTaxon None = 64
  optional hasBiologicalSequence None = 65
  repeated inPathwayWith None = 66
  repeated inComplexWith None = 67
  repeated inCellPopulationWith None = 68
  repeated expressedIn None = 69
 }
// A processual entity
message Occurrent
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated regulatesProcessToProcess None = 12
  repeated hasParticipant None = 13
  repeated hasInput None = 14
  repeated hasOutput None = 15
  repeated precedes None = 16
  repeated positivelyRegulatesProcessToProcess None = 17
  repeated negativelyRegulatesProcessToProcess None = 18
  repeated enabledBy None = 19
 }
// The age group in which manifestations appear
message Onset
 {
  optional hasAttributeType None = 1
  repeated hasQuantitativeValue None = 2
  optional hasQualitativeValue None = 3
  id None = 4
  name None = 5
  repeated category None = 6
  repeated relatedTo None = 7
  repeated interactsWith None = 8
  optional nodeProperty None = 9
  optional iri None = 10
  repeated synonym None = 11
  optional fullName None = 12
  optional description None = 13
  repeated systematicSynonym None = 14
  repeated subclassOf None = 15
 }
// a concept or class in an ontology, vocabulary or thesaurus
message OntologyClass
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated subclassOf None = 12
 }
message OrganismTaxon
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated subclassOf None = 12
 }
// An interaction between two genes or two gene products. May be physical (e.g. protein binding) or genetic (between genes). May be symmetric (e.g. protein interaction) or directed (e.g. phosphorylation)
message PairwiseGeneToGeneInteraction
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
 }
message Pathway
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated hasInput None = 13
  repeated hasOutput None = 14
  repeated enabledBy None = 15
  repeated regulatesProcessToProcess None = 16
  repeated hasParticipant None = 17
  repeated precedes None = 18
 }
// a fact or situation that is observed to exist or happen, especially one whose cause or explanation is in question
message Phenomenon
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated regulatesProcessToProcess None = 12
  repeated hasParticipant None = 13
  repeated hasInput None = 14
  repeated hasOutput None = 15
  repeated precedes None = 16
 }
message PhenotypicFeature
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated correlatedWith None = 13
  repeated hasBiomarker None = 14
  repeated treatedBy None = 15
  repeated inTaxon None = 16
 }
// An attribute corresponding to the phenotypic sex of the individual, based upon the reproductive organs present.
message PhenotypicSex
 {
  optional hasAttributeType None = 1
  repeated hasQuantitativeValue None = 2
  optional hasQualitativeValue None = 3
  id None = 4
  name None = 5
  repeated category None = 6
  repeated relatedTo None = 7
  repeated interactsWith None = 8
  optional nodeProperty None = 9
  optional iri None = 10
  repeated synonym None = 11
  optional fullName None = 12
  optional description None = 13
  repeated systematicSynonym None = 14
  repeated subclassOf None = 15
 }
// An entity that has physical properties such as mass, volume, or charge
message PhysicalEntity
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
 }
message PhysiologicalProcess
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated hasInput None = 13
  repeated hasOutput None = 14
  repeated enabledBy None = 15
  repeated regulatesProcessToProcess None = 16
  repeated hasParticipant None = 17
  repeated precedes None = 18
 }
// Any entity or process that exists at the level of the whole planet
message PlanetaryEntity
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
 }
// A collection of individuals from the same taxonomic class distinguished by one or more characteristics. Characteristics can include, but are not limited to, shared geographic location, genetics, phenotypes [Alliance for Genome Resources]
message PopulationOfIndividualOrganisms
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated inTaxon None = 13
 }
// An association between a two populations
message PopulationToPopulationAssociation
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
 }
// A series of actions conducted in a certain order or manner
message Procedure
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated regulatesProcessToProcess None = 12
  repeated hasParticipant None = 13
  repeated hasInput None = 14
  repeated hasOutput None = 15
  repeated precedes None = 16
 }
// A gene product that is composed of a chain of amino acid sequences and is produced by ribosome-mediated translation of mRNA
message Protein
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated molecularlyInteractsWith None = 13
  repeated affectsAbundanceOf None = 14
  repeated increasesAbundanceOf None = 15
  repeated decreasesAbundanceOf None = 16
  repeated affectsActivityOf None = 17
  repeated increasesActivityOf None = 18
  repeated decreasesActivityOf None = 19
  repeated affectsExpressionOf None = 20
  repeated increasesExpressionOf None = 21
  repeated decreasesExpressionOf None = 22
  repeated affectsFoldingOf None = 23
  repeated increasesFoldingOf None = 24
  repeated decreasesFoldingOf None = 25
  repeated affectsLocalizationOf None = 26
  repeated increasesLocalizationOf None = 27
  repeated decreasesLocalizationOf None = 28
  repeated affectsMetabolicProcessingOf None = 29
  repeated increasesMetabolicProcessingOf None = 30
  repeated decreasesMetabolicProcessingOf None = 31
  repeated affectsMolecularModificationOf None = 32
  repeated increasesMolecularModificationOf None = 33
  repeated decreasesMolecularModificationOf None = 34
  repeated affectsSynthesisOf None = 35
  repeated increasesSynthesisOf None = 36
  repeated decreasesSynthesisOf None = 37
  repeated affectsDegradationOf None = 38
  repeated increasesDegradationOf None = 39
  repeated decreasesDegradationOf None = 40
  repeated affectsMutationRateOf None = 41
  repeated increasesMutationRateOf None = 42
  repeated decreasesMutationRateOf None = 43
  repeated affectsResponseTo None = 44
  repeated increasesResponseTo None = 45
  repeated decreasesResponseTo None = 46
  repeated affectsSplicingOf None = 47
  repeated increasesSplicingOf None = 48
  repeated decreasesSplicingOf None = 49
  repeated affectsStabilityOf None = 50
  repeated increasesStabilityOf None = 51
  repeated decreasesStabilityOf None = 52
  repeated affectsTransportOf None = 53
  repeated increasesTransportOf None = 54
  repeated decreasesTransportOf None = 55
  repeated affectsSecretionOf None = 56
  repeated increasesSecretionOf None = 57
  repeated decreasesSecretionOf None = 58
  repeated affectsUptakeOf None = 59
  repeated increasesUptakeOf None = 60
  repeated decreasesUptakeOf None = 61
  repeated regulatesEntityToEntity None = 62
  repeated biomarkerFor None = 63
  repeated inTaxon None = 64
  optional hasBiologicalSequence None = 65
  repeated inPathwayWith None = 66
  repeated inComplexWith None = 67
  repeated inCellPopulationWith None = 68
  repeated expressedIn None = 69
 }
// Represents a protein that is a specific isoform of the canonical or reference protein. See https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114032/
message ProteinIsoform
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated molecularlyInteractsWith None = 13
  repeated affectsAbundanceOf None = 14
  repeated increasesAbundanceOf None = 15
  repeated decreasesAbundanceOf None = 16
  repeated affectsActivityOf None = 17
  repeated increasesActivityOf None = 18
  repeated decreasesActivityOf None = 19
  repeated affectsExpressionOf None = 20
  repeated increasesExpressionOf None = 21
  repeated decreasesExpressionOf None = 22
  repeated affectsFoldingOf None = 23
  repeated increasesFoldingOf None = 24
  repeated decreasesFoldingOf None = 25
  repeated affectsLocalizationOf None = 26
  repeated increasesLocalizationOf None = 27
  repeated decreasesLocalizationOf None = 28
  repeated affectsMetabolicProcessingOf None = 29
  repeated increasesMetabolicProcessingOf None = 30
  repeated decreasesMetabolicProcessingOf None = 31
  repeated affectsMolecularModificationOf None = 32
  repeated increasesMolecularModificationOf None = 33
  repeated decreasesMolecularModificationOf None = 34
  repeated affectsSynthesisOf None = 35
  repeated increasesSynthesisOf None = 36
  repeated decreasesSynthesisOf None = 37
  repeated affectsDegradationOf None = 38
  repeated increasesDegradationOf None = 39
  repeated decreasesDegradationOf None = 40
  repeated affectsMutationRateOf None = 41
  repeated increasesMutationRateOf None = 42
  repeated decreasesMutationRateOf None = 43
  repeated affectsResponseTo None = 44
  repeated increasesResponseTo None = 45
  repeated decreasesResponseTo None = 46
  repeated affectsSplicingOf None = 47
  repeated increasesSplicingOf None = 48
  repeated decreasesSplicingOf None = 49
  repeated affectsStabilityOf None = 50
  repeated increasesStabilityOf None = 51
  repeated decreasesStabilityOf None = 52
  repeated affectsTransportOf None = 53
  repeated increasesTransportOf None = 54
  repeated decreasesTransportOf None = 55
  repeated affectsSecretionOf None = 56
  repeated increasesSecretionOf None = 57
  repeated decreasesSecretionOf None = 58
  repeated affectsUptakeOf None = 59
  repeated increasesUptakeOf None = 60
  repeated decreasesUptakeOf None = 61
  repeated regulatesEntityToEntity None = 62
  repeated biomarkerFor None = 63
  repeated inTaxon None = 64
  optional hasBiologicalSequence None = 65
  repeated inPathwayWith None = 66
  repeated inComplexWith None = 67
  repeated inCellPopulationWith None = 68
  repeated expressedIn None = 69
 }
// person, group, organization or project that provides a piece of information
message Provider
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
 }
// Any published piece of information. Can refer to a whole publication, or to a part of it (e.g. a figure, figure legend, or section highlighted by NLP). The scope is intended to be general and include information published on the web as well as journals.
message Publication
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
 }
// A value of an attribute that is quantitative and measurable, expressed as a combination of a unit and a numeric value
message QuantityValue
 {
  optional hasUnit None = 1
  optional hasNumericValue None = 2
 }
// An OWL property used as an edge label
message RelationshipType
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated subclassOf None = 12
 }
message RNAProduct
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated molecularlyInteractsWith None = 13
  repeated affectsAbundanceOf None = 14
  repeated increasesAbundanceOf None = 15
  repeated decreasesAbundanceOf None = 16
  repeated affectsActivityOf None = 17
  repeated increasesActivityOf None = 18
  repeated decreasesActivityOf None = 19
  repeated affectsExpressionOf None = 20
  repeated increasesExpressionOf None = 21
  repeated decreasesExpressionOf None = 22
  repeated affectsFoldingOf None = 23
  repeated increasesFoldingOf None = 24
  repeated decreasesFoldingOf None = 25
  repeated affectsLocalizationOf None = 26
  repeated increasesLocalizationOf None = 27
  repeated decreasesLocalizationOf None = 28
  repeated affectsMetabolicProcessingOf None = 29
  repeated increasesMetabolicProcessingOf None = 30
  repeated decreasesMetabolicProcessingOf None = 31
  repeated affectsMolecularModificationOf None = 32
  repeated increasesMolecularModificationOf None = 33
  repeated decreasesMolecularModificationOf None = 34
  repeated affectsSynthesisOf None = 35
  repeated increasesSynthesisOf None = 36
  repeated decreasesSynthesisOf None = 37
  repeated affectsDegradationOf None = 38
  repeated increasesDegradationOf None = 39
  repeated decreasesDegradationOf None = 40
  repeated affectsMutationRateOf None = 41
  repeated increasesMutationRateOf None = 42
  repeated decreasesMutationRateOf None = 43
  repeated affectsResponseTo None = 44
  repeated increasesResponseTo None = 45
  repeated decreasesResponseTo None = 46
  repeated affectsSplicingOf None = 47
  repeated increasesSplicingOf None = 48
  repeated decreasesSplicingOf None = 49
  repeated affectsStabilityOf None = 50
  repeated increasesStabilityOf None = 51
  repeated decreasesStabilityOf None = 52
  repeated affectsTransportOf None = 53
  repeated increasesTransportOf None = 54
  repeated decreasesTransportOf None = 55
  repeated affectsSecretionOf None = 56
  repeated increasesSecretionOf None = 57
  repeated decreasesSecretionOf None = 58
  repeated affectsUptakeOf None = 59
  repeated increasesUptakeOf None = 60
  repeated decreasesUptakeOf None = 61
  repeated regulatesEntityToEntity None = 62
  repeated biomarkerFor None = 63
  repeated inTaxon None = 64
  optional hasBiologicalSequence None = 65
  repeated inPathwayWith None = 66
  repeated inComplexWith None = 67
  repeated inCellPopulationWith None = 68
  repeated expressedIn None = 69
 }
// Represents a protein that is a specific isoform of the canonical or reference RNA
message RNAProductIsoform
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated molecularlyInteractsWith None = 13
  repeated affectsAbundanceOf None = 14
  repeated increasesAbundanceOf None = 15
  repeated decreasesAbundanceOf None = 16
  repeated affectsActivityOf None = 17
  repeated increasesActivityOf None = 18
  repeated decreasesActivityOf None = 19
  repeated affectsExpressionOf None = 20
  repeated increasesExpressionOf None = 21
  repeated decreasesExpressionOf None = 22
  repeated affectsFoldingOf None = 23
  repeated increasesFoldingOf None = 24
  repeated decreasesFoldingOf None = 25
  repeated affectsLocalizationOf None = 26
  repeated increasesLocalizationOf None = 27
  repeated decreasesLocalizationOf None = 28
  repeated affectsMetabolicProcessingOf None = 29
  repeated increasesMetabolicProcessingOf None = 30
  repeated decreasesMetabolicProcessingOf None = 31
  repeated affectsMolecularModificationOf None = 32
  repeated increasesMolecularModificationOf None = 33
  repeated decreasesMolecularModificationOf None = 34
  repeated affectsSynthesisOf None = 35
  repeated increasesSynthesisOf None = 36
  repeated decreasesSynthesisOf None = 37
  repeated affectsDegradationOf None = 38
  repeated increasesDegradationOf None = 39
  repeated decreasesDegradationOf None = 40
  repeated affectsMutationRateOf None = 41
  repeated increasesMutationRateOf None = 42
  repeated decreasesMutationRateOf None = 43
  repeated affectsResponseTo None = 44
  repeated increasesResponseTo None = 45
  repeated decreasesResponseTo None = 46
  repeated affectsSplicingOf None = 47
  repeated increasesSplicingOf None = 48
  repeated decreasesSplicingOf None = 49
  repeated affectsStabilityOf None = 50
  repeated increasesStabilityOf None = 51
  repeated decreasesStabilityOf None = 52
  repeated affectsTransportOf None = 53
  repeated increasesTransportOf None = 54
  repeated decreasesTransportOf None = 55
  repeated affectsSecretionOf None = 56
  repeated increasesSecretionOf None = 57
  repeated decreasesSecretionOf None = 58
  repeated affectsUptakeOf None = 59
  repeated increasesUptakeOf None = 60
  repeated decreasesUptakeOf None = 61
  repeated regulatesEntityToEntity None = 62
  repeated biomarkerFor None = 63
  repeated inTaxon None = 64
  optional hasBiologicalSequence None = 65
  repeated inPathwayWith None = 66
  repeated inComplexWith None = 67
  repeated inCellPopulationWith None = 68
  repeated expressedIn None = 69
 }
// For example, a particular exon is part of a particular transcript or gene
message SequenceFeatureRelationship
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
 }
// An allele that varies in its sequence from what is considered the reference allele at that locus.
message SequenceVariant
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated molecularlyInteractsWith None = 13
  repeated affectsAbundanceOf None = 14
  repeated increasesAbundanceOf None = 15
  repeated decreasesAbundanceOf None = 16
  repeated affectsActivityOf None = 17
  repeated increasesActivityOf None = 18
  repeated decreasesActivityOf None = 19
  repeated affectsExpressionOf None = 20
  repeated increasesExpressionOf None = 21
  repeated decreasesExpressionOf None = 22
  repeated affectsFoldingOf None = 23
  repeated increasesFoldingOf None = 24
  repeated decreasesFoldingOf None = 25
  repeated affectsLocalizationOf None = 26
  repeated increasesLocalizationOf None = 27
  repeated decreasesLocalizationOf None = 28
  repeated affectsMetabolicProcessingOf None = 29
  repeated increasesMetabolicProcessingOf None = 30
  repeated decreasesMetabolicProcessingOf None = 31
  repeated affectsMolecularModificationOf None = 32
  repeated increasesMolecularModificationOf None = 33
  repeated decreasesMolecularModificationOf None = 34
  repeated affectsSynthesisOf None = 35
  repeated increasesSynthesisOf None = 36
  repeated decreasesSynthesisOf None = 37
  repeated affectsDegradationOf None = 38
  repeated increasesDegradationOf None = 39
  repeated decreasesDegradationOf None = 40
  repeated affectsMutationRateOf None = 41
  repeated increasesMutationRateOf None = 42
  repeated decreasesMutationRateOf None = 43
  repeated affectsResponseTo None = 44
  repeated increasesResponseTo None = 45
  repeated decreasesResponseTo None = 46
  repeated affectsSplicingOf None = 47
  repeated increasesSplicingOf None = 48
  repeated decreasesSplicingOf None = 49
  repeated affectsStabilityOf None = 50
  repeated increasesStabilityOf None = 51
  repeated decreasesStabilityOf None = 52
  repeated affectsTransportOf None = 53
  repeated increasesTransportOf None = 54
  repeated decreasesTransportOf None = 55
  repeated affectsSecretionOf None = 56
  repeated increasesSecretionOf None = 57
  repeated decreasesSecretionOf None = 58
  repeated affectsUptakeOf None = 59
  repeated increasesUptakeOf None = 60
  repeated decreasesUptakeOf None = 61
  repeated regulatesEntityToEntity None = 62
  repeated biomarkerFor None = 63
  repeated inTaxon None = 64
  optional hasBiologicalSequence None = 65
  repeated hasGene None = 66
 }
// describes the severity of a phenotypic feature or disease
message SeverityValue
 {
  optional hasAttributeType None = 1
  repeated hasQuantitativeValue None = 2
  optional hasQualitativeValue None = 3
  id None = 4
  name None = 5
  repeated category None = 6
  repeated relatedTo None = 7
  repeated interactsWith None = 8
  optional nodeProperty None = 9
  optional iri None = 10
  repeated synonym None = 11
  optional fullName None = 12
  optional description None = 13
  repeated systematicSynonym None = 14
  repeated subclassOf None = 15
 }
message SourceFile
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  optional sourceVersion None = 12
  optional retrievedOn None = 13
 }
// An RNA synthesized on a DNA or RNA template by an RNA polymerase
message Transcript
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated molecularlyInteractsWith None = 13
  repeated affectsAbundanceOf None = 14
  repeated increasesAbundanceOf None = 15
  repeated decreasesAbundanceOf None = 16
  repeated affectsActivityOf None = 17
  repeated increasesActivityOf None = 18
  repeated decreasesActivityOf None = 19
  repeated affectsExpressionOf None = 20
  repeated increasesExpressionOf None = 21
  repeated decreasesExpressionOf None = 22
  repeated affectsFoldingOf None = 23
  repeated increasesFoldingOf None = 24
  repeated decreasesFoldingOf None = 25
  repeated affectsLocalizationOf None = 26
  repeated increasesLocalizationOf None = 27
  repeated decreasesLocalizationOf None = 28
  repeated affectsMetabolicProcessingOf None = 29
  repeated increasesMetabolicProcessingOf None = 30
  repeated decreasesMetabolicProcessingOf None = 31
  repeated affectsMolecularModificationOf None = 32
  repeated increasesMolecularModificationOf None = 33
  repeated decreasesMolecularModificationOf None = 34
  repeated affectsSynthesisOf None = 35
  repeated increasesSynthesisOf None = 36
  repeated decreasesSynthesisOf None = 37
  repeated affectsDegradationOf None = 38
  repeated increasesDegradationOf None = 39
  repeated decreasesDegradationOf None = 40
  repeated affectsMutationRateOf None = 41
  repeated increasesMutationRateOf None = 42
  repeated decreasesMutationRateOf None = 43
  repeated affectsResponseTo None = 44
  repeated increasesResponseTo None = 45
  repeated decreasesResponseTo None = 46
  repeated affectsSplicingOf None = 47
  repeated increasesSplicingOf None = 48
  repeated decreasesSplicingOf None = 49
  repeated affectsStabilityOf None = 50
  repeated increasesStabilityOf None = 51
  repeated decreasesStabilityOf None = 52
  repeated affectsTransportOf None = 53
  repeated increasesTransportOf None = 54
  repeated decreasesTransportOf None = 55
  repeated affectsSecretionOf None = 56
  repeated increasesSecretionOf None = 57
  repeated decreasesSecretionOf None = 58
  repeated affectsUptakeOf None = 59
  repeated increasesUptakeOf None = 60
  repeated decreasesUptakeOf None = 61
  repeated regulatesEntityToEntity None = 62
  repeated biomarkerFor None = 63
  repeated inTaxon None = 64
  optional hasBiologicalSequence None = 65
 }
// A gene is a collection of transcripts
message TranscriptToGeneRelationship
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
 }
// A treatment is targeted at a disease or phenotype and may involve multiple drug 'exposures'
message Treatment
 {
  id None = 1
  name None = 2
  repeated category None = 3
  repeated relatedTo None = 4
  repeated interactsWith None = 5
  optional nodeProperty None = 6
  optional iri None = 7
  repeated synonym None = 8
  optional fullName None = 9
  optional description None = 10
  repeated systematicSynonym None = 11
  repeated hasPhenotype None = 12
  repeated treats None = 13
  repeated hasExposureParts None = 14
 }
message VariantToDiseaseAssociation
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
  optional frequencyQualifier None = 12
  optional severityQualifier None = 13
  optional onsetQualifier None = 14
 }
message VariantToPhenotypicFeatureAssociation
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
  optional sexQualifier None = 12
  optional frequencyQualifier None = 13
  optional severityQualifier None = 14
  optional onsetQualifier None = 15
 }
// An association between a variant and a population, where the variant has particular frequency in the population
message VariantToPopulationAssociation
 {
  subject None = 1
  relation None = 2
  object None = 3
  id None = 4
  optional negated None = 5
  optional associationType None = 6
  repeated qualifiers None = 7
  repeated publications None = 8
  optional providedBy None = 9
  optional associationSlot None = 10
  edgeLabel None = 11
  optional hasCount None = 12
  optional hasTotal None = 13
  optional hasQuotient None = 14
  optional hasPercentage None = 15
  optional frequencyQualifier None = 16
 }
message Zygosity
 {
  optional hasAttributeType None = 1
  repeated hasQuantitativeValue None = 2
  optional hasQualitativeValue None = 3
  id None = 4
  name None = 5
  repeated category None = 6
  repeated relatedTo None = 7
  repeated interactsWith None = 8
  optional nodeProperty None = 9
  optional iri None = 10
  repeated synonym None = 11
  optional fullName None = 12
  optional description None = 13
  repeated systematicSynonym None = 14
  repeated subclassOf None = 15
 }