biolink-model.shex

BASE <https://w3id.org/biolink/vocab/>
PREFIX rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#>
PREFIX rdfs: <http://www.w3.org/2000/01/rdf-schema#>
PREFIX xsd: <http://www.w3.org/2001/XMLSchema#>
PREFIX OBAN: <http://purl.org/oban/>
PREFIX OBO: <http://purl.obolibrary.org/obo/>
PREFIX dcterms: <http://purl.org/dc/terms/>
PREFIX faldo: <http://biohackathon.org/resource/faldo#>
PREFIX owl: <http://www.w3.org/2002/07/owl#>
PREFIX pav: <http://purl.org/pav/>
PREFIX void: <http://rdfs.org/ns/void#>
PREFIX metatype: <https://w3id.org/biolink/biolinkml/type/>
PREFIX SEMMEDDB: <http://example.org/UNKNOWN/SEMMEDDB/>
PREFIX WD: <http://example.org/UNKNOWN/WD/>
PREFIX dct: <http://example.org/UNKNOWN/dct/>


<ChemicalFormulaValue> xsd:string

<IdentifierType> IRI

<IriType> IRI

<LabelType> xsd:string

<NarrativeText> xsd:string

<SymbolType> xsd:string

<Frequency> OBO:UO_0000105

<PercentageFrequencyValue> OBO:UO_0000187

<Quotient> OBO:UO_0010006

<Unit> OBO:UO_0000000

<TimeType> xsd:dateTime

<BiologicalSequence> xsd:string

metatype:String xsd:string

metatype:Integer xsd:integer

metatype:Boolean xsd:boolean

metatype:Float xsd:float

metatype:Double xsd:double

metatype:Time xsd:dateTime

metatype:Date xsd:date

metatype:Datetime xsd:dateTime

metatype:Uriorcurie IRI

metatype:Uri IRI

metatype:Ncname xsd:string

metatype:Objectidentifier IRI

metatype:Nodeidentifier NONLITERAL

<AbstractEntity>  (
    CLOSED {
       (  $<AbstractEntity_tes> rdf:type . * ;
          rdf:type [ <AbstractEntity> ] ?
       )
    } OR @<Attribute> OR @<QuantityValue>
)

<ActivityAndBehavior> CLOSED {
    (  $<ActivityAndBehavior_tes> (  &<Occurrent_tes> ;
          rdf:type [ OBO:BFO_0000003 ] ?
       ) ;
       rdf:type [ <ActivityAndBehavior> ]
    )
}

<AdministrativeEntity>  (
    {
       (  $<AdministrativeEntity_tes> (  &<NamedThing_tes> ;
             rdf:type [ WD:Q35120 ] ?
          ) ;
          rdf:type [ <AdministrativeEntity> ]
       )
    } OR @<Provider>
)

<AnatomicalEntity>  (
    CLOSED {
       (  $<AnatomicalEntity_tes> (  &<OrganismalEntity_tes> ;
             rdf:type [ WD:Q7239 ] ? ;
             &<ThingWithTaxon_tes> ;
             rdf:type [ <ThingWithTaxon> ] ? ;
             &<PhysicalEntity_tes> ;
             rdf:type [ <PhysicalEntity> ] ? ;
             OBO:RO_0002292 @<GeneOrGeneProduct> * ;
             OBO:RO_0002162 @<OrganismTaxon> *
          ) ;
          rdf:type [ <http://semanticscience.org/resource/SIO_010046> ]
       )
    } OR @<Cell> OR @<CellularComponent> OR @<GrossAnatomicalStructure>
)

<AnatomicalEntityToAnatomicalEntityAssociation>  (
    CLOSED {
       (  $<AnatomicalEntityToAnatomicalEntityAssociation_tes> (  &<Association_tes> ;
             rdf:type [ OBAN:association ] ? ;
             <subject> @<AnatomicalEntity> ;
             <object> @<AnatomicalEntity>
          ) ;
          rdf:type [ <AnatomicalEntityToAnatomicalEntityAssociation> ]
       )
    } OR @<AnatomicalEntityToAnatomicalEntityOntogenicAssociation> OR @<AnatomicalEntityToAnatomicalEntityPartOfAssociation>
)

<AnatomicalEntityToAnatomicalEntityOntogenicAssociation> CLOSED {
    (  $<AnatomicalEntityToAnatomicalEntityOntogenicAssociation_tes> (  &<AnatomicalEntityToAnatomicalEntityAssociation_tes> ;
          rdf:type [ <AnatomicalEntityToAnatomicalEntityAssociation> ] ? ;
          <subject> @<AnatomicalEntity> ;
          <relation> @metatype:Uriorcurie ;
          <object> @<AnatomicalEntity>
       ) ;
       rdf:type [ <AnatomicalEntityToAnatomicalEntityOntogenicAssociation> ]
    )
}

<AnatomicalEntityToAnatomicalEntityPartOfAssociation> CLOSED {
    (  $<AnatomicalEntityToAnatomicalEntityPartOfAssociation_tes> (  &<AnatomicalEntityToAnatomicalEntityAssociation_tes> ;
          rdf:type [ <AnatomicalEntityToAnatomicalEntityAssociation> ] ? ;
          <subject> @<AnatomicalEntity> ;
          <relation> @metatype:Uriorcurie ;
          <object> @<AnatomicalEntity>
       ) ;
       rdf:type [ <AnatomicalEntityToAnatomicalEntityPartOfAssociation> ]
    )
}

<Association>  (
    CLOSED {
       (  $<Association_tes> (  rdf:subject @<NamedThing> ;
             rdf:predicate @metatype:Uriorcurie ;
             rdf:object @<NamedThing> ;
             <negated> @metatype:Boolean ? ;
             rdf:type @<OntologyClass> ? ;
             <qualifiers> @<OntologyClass> * ;
             <publications> @<Publication> * ;
             pav:providedBy @<Provider> ? ;
             <edge_label> @<LabelType> ;
             <has_confidence_level> @<ConfidenceLevel> ? ;
             OBO:RO_0002558 @<EvidenceType> ? ;
             <stage_qualifier> @<LifeStage> ? ;
             <quantifier_qualifier> @<OntologyClass> ? ;
             <frequency_qualifier> @<FrequencyValue> ? ;
             <severity_qualifier> @<SeverityValue> ? ;
             <sex_qualifier> @<BiologicalSex> ? ;
             <onset_qualifier> @<Onset> ? ;
             <clinical_modifier_qualifier> @<ClinicalModifier> ? ;
             <sequence_variant_qualifier> @<SequenceVariant> ? ;
             <change_is_catalyzed_by> @<MacromolecularMachine> *
          ) ;
          rdf:type [ OBAN:association ]
       )
    } OR @<AnatomicalEntityToAnatomicalEntityAssociation> OR @<CaseToPhenotypicFeatureAssociation> OR @<CaseToThingAssociation> OR
    @<CellLineToDiseaseOrPhenotypicFeatureAssociation> OR @<CellLineToThingAssociation> OR @<ChemicalToChemicalAssociation> OR
    @<ChemicalToDiseaseOrPhenotypicFeatureAssociation> OR @<ChemicalToGeneAssociation> OR @<ChemicalToPathwayAssociation> OR
    @<ChemicalToThingAssociation> OR @<DiseaseOrPhenotypicFeatureAssociationToThingAssociation> OR
    @<DiseaseToPhenotypicFeatureAssociation> OR @<DiseaseToThingAssociation> OR @<EntityToPhenotypicFeatureAssociation> OR
    @<EnvironmentToPhenotypicFeatureAssociation> OR @<FunctionalAssociation> OR @<GeneRegulatoryRelationship> OR
    @<GeneToDiseaseAssociation> OR @<GeneToExpressionSiteAssociation> OR @<GeneToGeneAssociation> OR
    @<GeneToPhenotypicFeatureAssociation> OR @<GeneToThingAssociation> OR @<GenomicSequenceLocalization> OR
    @<GenotypeToGeneAssociation> OR @<GenotypeToGenotypePartAssociation> OR @<GenotypeToPhenotypicFeatureAssociation> OR
    @<GenotypeToThingAssociation> OR @<GenotypeToVariantAssociation> OR @<MaterialSampleDerivationAssociation> OR
    @<MaterialSampleToDiseaseOrPhenotypicFeatureAssociation> OR @<MaterialSampleToThingAssociation> OR
    @<PairwiseInteractionAssociation> OR @<PopulationToPopulationAssociation> OR @<SequenceFeatureRelationship> OR
    @<SequenceVariantModulatesTreatmentAssociation> OR @<ThingToDiseaseOrPhenotypicFeatureAssociation> OR
    @<VariantToDiseaseAssociation> OR @<VariantToPhenotypicFeatureAssociation> OR @<VariantToPopulationAssociation> OR
    @<VariantToThingAssociation>
)

<Attribute>  (
    CLOSED {
       (  $<Attribute_tes> (  &<AbstractEntity_tes> ;
             rdf:type [ <AbstractEntity> ] ? ;
             &<OntologyClass_tes> ;
             rdf:type [ <OntologyClass> ] ? ;
             <has_attribute_type> @<OntologyClass> ? ;
             <has_quantitative_value> @<QuantityValue> * ;
             <has_qualitative_value> @<NamedThing> ? ;
             rdfs:label @<LabelType> ;
             rdfs:subClassOf @<IriType> + ;
             owl:ObjectProperty @<NamedThing> * ;
             OBO:RO_0002434 @<NamedThing> * ;
             <node_property> @metatype:String ? ;
             <iri> @<IriType> ? ;
             <synonym> @<LabelType> * ;
             <full_name> @<LabelType> ? ;
             dcterms:description @<NarrativeText> ? ;
             <systematic_synonym> @<LabelType> * ;
             rdfs:subClassOf @<IriType> *
          ) ;
          rdf:type [ <Attribute> ]
       )
    } OR @<BiologicalSex> OR @<ClinicalModifier> OR @<FrequencyValue> OR @<Onset> OR @<SeverityValue> OR @<Zygosity>
)

<BiologicalEntity>  (
    @<BiologicalProcessOrActivity> OR @<DiseaseOrPhenotypicFeature> OR @<Environment> OR @<MolecularEntity> OR @<OrganismalEntity>
)

<BiologicalEntity_struct> {
    (  $<BiologicalEntity_tes> (  &<NamedThing_tes> ;
          rdf:type [ WD:Q35120 ] ? ;
          OBO:RO_0002200 @<PhenotypicFeature> *
       ) ;
       rdf:type [ WD:Q28845870 ]
    )
}

<BiologicalProcess>  (
    CLOSED {
       (  $<BiologicalProcess_tes> (  &<BiologicalProcessOrActivity_tes> ;
             rdf:type [ <BiologicalProcessOrActivity> ] ? ;
             &<Occurrent_tes> ;
             rdf:type [ OBO:BFO_0000003 ] ?
          ) ;
          rdf:type [ OBO:GO_0008150 ]
       )
    } OR @<Pathway> OR @<PhysiologicalProcess>
)

<BiologicalProcessOrActivity>  (
    CLOSED {
       (  $<BiologicalProcessOrActivity_tes> (  &<BiologicalEntity_tes> ;
             rdf:type [ WD:Q28845870 ] ? ;
             &<Occurrent_tes> ;
             rdf:type [ OBO:BFO_0000003 ] ? ;
             OBO:RO_0002233 @<NamedThing> * ;
             OBO:RO_0002234 @<NamedThing> * ;
             OBO:RO_0002333 @<BiologicalProcessOrActivity> * ;
             OBO:RO_0002211 @<Occurrent> * ;
             OBO:RO_0000057 @<NamedThing> * ;
             OBO:BFO_0000063 @<Occurrent> *
          ) ;
          rdf:type [ <BiologicalProcessOrActivity> ]
       )
    } OR @<BiologicalProcess> OR @<MolecularActivity>
)

<BiologicalSex>  (
    CLOSED {
       (  $<BiologicalSex_tes> (  &<Attribute_tes> ;
             rdf:type [ <Attribute> ] ?
          ) ;
          rdf:type [ <BiologicalSex> ]
       )
    } OR @<GenotypicSex> OR @<PhenotypicSex>
)

<Carbohydrate> CLOSED {
    (  $<Carbohydrate_tes> (  &<ChemicalSubstance_tes> ;
          rdf:type [ <http://semanticscience.org/resource/SIO_010004> ] ?
       ) ;
       rdf:type [ <Carbohydrate> ]
    )
}

<Case> CLOSED {
    (  $<Case_tes> (  &<IndividualOrganism_tes> ;
          rdf:type [ <http://semanticscience.org/resource/SIO_010000> ] ?
       ) ;
       rdf:type [ <Case> ]
    )
}

<CaseToPhenotypicFeatureAssociation> CLOSED {
    (  $<CaseToPhenotypicFeatureAssociation_tes> (  &<Association_tes> ;
          rdf:type [ OBAN:association ] ? ;
          &<EntityToPhenotypicFeatureAssociation_tes> ;
          rdf:type [ <EntityToPhenotypicFeatureAssociation> ] ? ;
          &<CaseToThingAssociation_tes> ;
          rdf:type [ <CaseToThingAssociation> ] ?
       ) ;
       rdf:type [ <CaseToPhenotypicFeatureAssociation> ]
    )
}

<CaseToThingAssociation> {
    (  $<CaseToThingAssociation_tes> (  &<Association_tes> ;
          rdf:type [ OBAN:association ] ? ;
          <subject> @<Case>
       ) ;
       rdf:type [ <CaseToThingAssociation> ]
    )
}

<Cell> CLOSED {
    (  $<Cell_tes> (  &<AnatomicalEntity_tes> ;
          rdf:type [ <http://semanticscience.org/resource/SIO_010046> ] ?
       ) ;
       rdf:type [ OBO:GO_0005623 ]
    )
}

<CellLine> CLOSED {
    (  $<CellLine_tes> (  &<OrganismalEntity_tes> ;
          rdf:type [ WD:Q7239 ] ?
       ) ;
       rdf:type [ OBO:CLO_0000031 ]
    )
}

<CellLineToDiseaseOrPhenotypicFeatureAssociation> CLOSED {
    (  $<CellLineToDiseaseOrPhenotypicFeatureAssociation_tes> (  &<Association_tes> ;
          rdf:type [ OBAN:association ] ? ;
          &<CellLineToThingAssociation_tes> ;
          rdf:type [ <CellLineToThingAssociation> ] ? ;
          &<ThingToDiseaseOrPhenotypicFeatureAssociation_tes> ;
          rdf:type [ <ThingToDiseaseOrPhenotypicFeatureAssociation> ] ? ;
          <subject> @<DiseaseOrPhenotypicFeature>
       ) ;
       rdf:type [ <CellLineToDiseaseOrPhenotypicFeatureAssociation> ]
    )
}

<CellLineToThingAssociation> {
    (  $<CellLineToThingAssociation_tes> (  &<Association_tes> ;
          rdf:type [ OBAN:association ] ? ;
          <subject> @<CellLine>
       ) ;
       rdf:type [ <CellLineToThingAssociation> ]
    )
}

<CellularComponent> CLOSED {
    (  $<CellularComponent_tes> (  &<AnatomicalEntity_tes> ;
          rdf:type [ <http://semanticscience.org/resource/SIO_010046> ] ?
       ) ;
       rdf:type [ OBO:GO_0005575 ]
    )
}

<ChemicalSubstance>  (
    CLOSED {
       (  $<ChemicalSubstance_tes> (  &<MolecularEntity_tes> ;
             rdf:type [ <http://semanticscience.org/resource/SIO_010341> ] ?
          ) ;
          rdf:type [ <http://semanticscience.org/resource/SIO_010004> ]
       )
    } OR @<Carbohydrate> OR @<Drug> OR @<Metabolite>
)

<ChemicalToChemicalAssociation>  (
    CLOSED {
       (  $<ChemicalToChemicalAssociation_tes> (  &<Association_tes> ;
             rdf:type [ OBAN:association ] ? ;
             &<ChemicalToThingAssociation_tes> ;
             rdf:type [ <ChemicalToThingAssociation> ] ? ;
             <object> @<ChemicalSubstance>
          ) ;
          rdf:type [ <ChemicalToChemicalAssociation> ]
       )
    } OR @<ChemicalToChemicalDerivationAssociation>
)

<ChemicalToChemicalDerivationAssociation> CLOSED {
    (  $<ChemicalToChemicalDerivationAssociation_tes> (  &<ChemicalToChemicalAssociation_tes> ;
          rdf:type [ <ChemicalToChemicalAssociation> ] ? ;
          <subject> @<ChemicalSubstance> ;
          <relation> @metatype:Uriorcurie ;
          <object> @<ChemicalSubstance> ;
          <change_is_catalyzed_by> @<MacromolecularMachine> *
       ) ;
       rdf:type [ <ChemicalToChemicalDerivationAssociation> ]
    )
}

<ChemicalToDiseaseOrPhenotypicFeatureAssociation> CLOSED {
    (  $<ChemicalToDiseaseOrPhenotypicFeatureAssociation_tes> (  &<Association_tes> ;
          rdf:type [ OBAN:association ] ? ;
          &<ChemicalToThingAssociation_tes> ;
          rdf:type [ <ChemicalToThingAssociation> ] ? ;
          &<ThingToDiseaseOrPhenotypicFeatureAssociation_tes> ;
          rdf:type [ <ThingToDiseaseOrPhenotypicFeatureAssociation> ] ? ;
          <object> @<DiseaseOrPhenotypicFeature>
       ) ;
       rdf:type [ <http://semanticscience.org/resource/SIO_000993> ]
    )
}

<ChemicalToGeneAssociation> CLOSED {
    (  $<ChemicalToGeneAssociation_tes> (  &<Association_tes> ;
          rdf:type [ OBAN:association ] ? ;
          &<ChemicalToThingAssociation_tes> ;
          rdf:type [ <ChemicalToThingAssociation> ] ? ;
          <object> @<GeneOrGeneProduct>
       ) ;
       rdf:type [ <http://semanticscience.org/resource/SIO_001257> ]
    )
}

<ChemicalToPathwayAssociation> CLOSED {
    (  $<ChemicalToPathwayAssociation_tes> (  &<Association_tes> ;
          rdf:type [ OBAN:association ] ? ;
          &<ChemicalToThingAssociation_tes> ;
          rdf:type [ <ChemicalToThingAssociation> ] ? ;
          <object> @<Pathway>
       ) ;
       rdf:type [ <http://semanticscience.org/resource/SIO_001250> ]
    )
}

<ChemicalToThingAssociation> {
    (  $<ChemicalToThingAssociation_tes> (  &<Association_tes> ;
          rdf:type [ OBAN:association ] ? ;
          <subject> @<ChemicalSubstance>
       ) ;
       rdf:type [ <ChemicalToThingAssociation> ]
    )
}

<ClinicalEntity>  (
    CLOSED {
       (  $<ClinicalEntity_tes> (  &<NamedThing_tes> ;
             rdf:type [ WD:Q35120 ] ?
          ) ;
          rdf:type [ <ClinicalEntity> ]
       )
    } OR @<ClinicalIntervention> OR @<ClinicalTrial>
)

<ClinicalIntervention> CLOSED {
    (  $<ClinicalIntervention_tes> (  &<ClinicalEntity_tes> ;
          rdf:type [ <ClinicalEntity> ] ?
       ) ;
       rdf:type [ <ClinicalIntervention> ]
    )
}

<ClinicalModifier> CLOSED {
    (  $<ClinicalModifier_tes> (  &<Attribute_tes> ;
          rdf:type [ <Attribute> ] ?
       ) ;
       rdf:type [ <ClinicalModifier> ]
    )
}

<ClinicalTrial> CLOSED {
    (  $<ClinicalTrial_tes> (  &<ClinicalEntity_tes> ;
          rdf:type [ <ClinicalEntity> ] ?
       ) ;
       rdf:type [ <ClinicalTrial> ]
    )
}

<CodingSequence> CLOSED {
    (  $<CodingSequence_tes> (  &<GenomicEntity_tes> ;
          rdf:type [ OBO:SO_0000110 ] ?
       ) ;
       rdf:type [ OBO:SO_0000316 ]
    )
}

<ConfidenceLevel> CLOSED {
    (  $<ConfidenceLevel_tes> (  &<InformationContentEntity_tes> ;
          rdf:type [ OBO:IAO_0000030 ] ?
       ) ;
       rdf:type [ OBO:CIO_0000028 ]
    )
}

<DataFile>  (
    CLOSED {
       (  $<DataFile_tes> (  &<NamedThing_tes> ;
             rdf:type [ WD:Q35120 ] ?
          ) ;
          rdf:type [ OBO:EFO_0004095 ]
       )
    } OR @<SourceFile>
)

<DataSet>  (
    CLOSED {
       (  $<DataSet_tes> (  &<NamedThing_tes> ;
             rdf:type [ WD:Q35120 ] ?
          ) ;
          rdf:type [ OBO:IAO_0000100 ]
       )
    } OR @<DataSetVersion>
)

<DataSetSummary> {
    (  $<DataSetSummary_tes> (  &<DataSetVersion_tes> ;
          rdf:type [ <DataSetVersion> ] ? ;
          dcterms:source @metatype:String ?
       ) ;
       rdf:type [ <DataSetSummary> ]
    )
}

<DataSetVersion>  (
    CLOSED {
       (  $<DataSetVersion_tes> (  &<DataSet_tes> ;
             rdf:type [ OBO:IAO_0000100 ] ? ;
             dct:title @metatype:String ? ;
             dcterms:source @<DataFile> ? ;
             dct:isVersionOf @<DataSet> ? ;
             rdf:type @metatype:String ? ;
             void:Dataset @<DistributionLevel> ?
          ) ;
          rdf:type [ <DataSetVersion> ]
       )
    } OR @<DataSetSummary> OR @<DistributionLevel>
)

<Device> CLOSED {
    (  $<Device_tes> (  &<NamedThing_tes> ;
          rdf:type [ WD:Q35120 ] ?
       ) ;
       rdf:type [ <Device> ]
    )
}

<Disease> CLOSED {
    (  $<Disease_tes> (  &<DiseaseOrPhenotypicFeature_tes> ;
          rdf:type [ <DiseaseOrPhenotypicFeature> ] ?
       ) ;
       rdf:type [ OBO:MONDO_0000001 ]
    )
}

<DiseaseOrPhenotypicFeature>  (
    CLOSED {
       (  $<DiseaseOrPhenotypicFeature_tes> (  &<BiologicalEntity_tes> ;
             rdf:type [ WD:Q28845870 ] ? ;
             &<ThingWithTaxon_tes> ;
             rdf:type [ <ThingWithTaxon> ] ? ;
             OBO:RO_0002610 @<MolecularEntity> * ;
             <has_biomarker> @<MolecularEntity> * ;
             OBO:RO_0002302 @<NamedThing> * ;
             OBO:RO_0002162 @<OrganismTaxon> *
          ) ;
          rdf:type [ <DiseaseOrPhenotypicFeature> ]
       )
    } OR @<Disease> OR @<PhenotypicFeature>
)

<DiseaseOrPhenotypicFeatureAssociationToLocationAssociation> CLOSED {
    (  $<DiseaseOrPhenotypicFeatureAssociationToLocationAssociation_tes> ( 
          &<DiseaseOrPhenotypicFeatureAssociationToThingAssociation_tes> ;
          rdf:type [ <DiseaseOrPhenotypicFeatureAssociationToThingAssociation> ] ? ;
          <object> @<AnatomicalEntity>
       ) ;
       rdf:type [ OBO:NCIT_R100 ]
    )
}

<DiseaseOrPhenotypicFeatureAssociationToThingAssociation>  (
    {
       (  $<DiseaseOrPhenotypicFeatureAssociationToThingAssociation_tes> (  &<Association_tes> ;
             rdf:type [ OBAN:association ] ? ;
             <subject> @<DiseaseOrPhenotypicFeature>
          ) ;
          rdf:type [ <DiseaseOrPhenotypicFeatureAssociationToThingAssociation> ]
       )
    } OR @<DiseaseOrPhenotypicFeatureAssociationToLocationAssociation>
)

<DiseaseToPhenotypicFeatureAssociation> CLOSED {
    (  $<DiseaseToPhenotypicFeatureAssociation_tes> (  &<Association_tes> ;
          rdf:type [ OBAN:association ] ? ;
          &<EntityToPhenotypicFeatureAssociation_tes> ;
          rdf:type [ <EntityToPhenotypicFeatureAssociation> ] ? ;
          &<DiseaseToThingAssociation_tes> ;
          rdf:type [ <DiseaseToThingAssociation> ] ?
       ) ;
       rdf:type [ <DiseaseToPhenotypicFeatureAssociation> ]
    )
}

<DiseaseToThingAssociation> {
    (  $<DiseaseToThingAssociation_tes> (  &<Association_tes> ;
          rdf:type [ OBAN:association ] ? ;
          <subject> @<Disease>
       ) ;
       rdf:type [ <DiseaseToThingAssociation> ]
    )
}

<DistributionLevel> {
    (  $<DistributionLevel_tes> (  &<DataSetVersion_tes> ;
          rdf:type [ <DataSetVersion> ] ? ;
          dct:downloadURL @metatype:String ?
       ) ;
       rdf:type [ <DistributionLevel> ]
    )
}

<Drug> CLOSED {
    (  $<Drug_tes> (  &<ChemicalSubstance_tes> ;
          rdf:type [ <http://semanticscience.org/resource/SIO_010004> ] ?
       ) ;
       rdf:type [ WD:Q12140 ]
    )
}

<DrugExposure> CLOSED {
    (  $<DrugExposure_tes> (  &<Environment_tes> ;
          rdf:type [ <http://semanticscience.org/resource/SIO_000955> ] ? ;
          <drug> @<ChemicalSubstance> +
       ) ;
       rdf:type [ <http://example.org/UNKNOWN/ECTO/0000509> ]
    )
}

<EntityToDiseaseAssociation> {
    (  $<EntityToDiseaseAssociation_tes> (  &<EntityToFeatureOrDiseaseQualifiers_tes> ;
          rdf:type [ <EntityToFeatureOrDiseaseQualifiers> ] ? ;
          <object> @<Disease>
       ) ;
       rdf:type [ <EntityToDiseaseAssociation> ] ?
    )
}

<EntityToFeatureOrDiseaseQualifiers>  (
    {
       (  $<EntityToFeatureOrDiseaseQualifiers_tes> (  &<FrequencyQualifierMixin_tes> ;
             rdf:type [ <FrequencyQualifierMixin> ] ? ;
             <severity_qualifier> @<SeverityValue> ? ;
             <onset_qualifier> @<Onset> ?
          ) ;
          rdf:type [ <EntityToFeatureOrDiseaseQualifiers> ] ?
       )
    } OR @<EntityToDiseaseAssociation>
)

<EntityToPhenotypicFeatureAssociation> {
    (  $<EntityToPhenotypicFeatureAssociation_tes> (  &<Association_tes> ;
          rdf:type [ OBAN:association ] ? ;
          &<EntityToFeatureOrDiseaseQualifiers_tes> ;
          rdf:type [ <EntityToFeatureOrDiseaseQualifiers> ] ? ;
          <object> @<PhenotypicFeature> ;
          <description> @<NarrativeText> ?
       ) ;
       rdf:type [ <EntityToPhenotypicFeatureAssociation> ]
    )
}

<Environment>  (
    CLOSED {
       (  $<Environment_tes> (  &<BiologicalEntity_tes> ;
             rdf:type [ WD:Q28845870 ] ?
          ) ;
          rdf:type [ <http://semanticscience.org/resource/SIO_000955> ]
       )
    } OR @<DrugExposure> OR @<Treatment>
)

<EnvironmentToPhenotypicFeatureAssociation> CLOSED {
    (  $<EnvironmentToPhenotypicFeatureAssociation_tes> (  &<Association_tes> ;
          rdf:type [ OBAN:association ] ? ;
          &<EntityToPhenotypicFeatureAssociation_tes> ;
          rdf:type [ <EntityToPhenotypicFeatureAssociation> ] ? ;
          <subject> @<Environment>
       ) ;
       rdf:type [ <EnvironmentToPhenotypicFeatureAssociation> ]
    )
}

<EnvironmentalFeature> CLOSED {
    (  $<EnvironmentalFeature_tes> (  &<PlanetaryEntity_tes> ;
          rdf:type [ <PlanetaryEntity> ] ?
       ) ;
       rdf:type [ <EnvironmentalFeature> ]
    )
}

<EnvironmentalProcess> CLOSED {
    (  $<EnvironmentalProcess_tes> (  &<PlanetaryEntity_tes> ;
          rdf:type [ <PlanetaryEntity> ] ? ;
          &<Occurrent_tes> ;
          rdf:type [ OBO:BFO_0000003 ] ? ;
          OBO:RO_0002211 @<Occurrent> * ;
          OBO:RO_0000057 @<NamedThing> * ;
          OBO:RO_0002233 @<NamedThing> * ;
          OBO:RO_0002234 @<NamedThing> * ;
          OBO:BFO_0000063 @<Occurrent> *
       ) ;
       rdf:type [ <EnvironmentalProcess> ]
    )
}

<EvidenceType> CLOSED {
    (  $<EvidenceType_tes> (  &<InformationContentEntity_tes> ;
          rdf:type [ OBO:IAO_0000030 ] ?
       ) ;
       rdf:type [ OBO:ECO_0000000 ]
    )
}

<Exon> CLOSED {
    (  $<Exon_tes> (  &<GenomicEntity_tes> ;
          rdf:type [ OBO:SO_0000110 ] ?
       ) ;
       rdf:type [ OBO:SO_0000147 ]
    )
}

<ExonToTranscriptRelationship> CLOSED {
    (  $<ExonToTranscriptRelationship_tes> (  &<SequenceFeatureRelationship_tes> ;
          rdf:type [ <SequenceFeatureRelationship> ] ? ;
          <subject> @<Exon> ;
          <object> @<Transcript>
       ) ;
       rdf:type [ <ExonToTranscriptRelationship> ]
    )
}

<FrequencyQualifierMixin>  (
    {
       (  $<FrequencyQualifierMixin_tes> <frequency_qualifier> @<FrequencyValue> ? ;
          rdf:type [ <FrequencyQualifierMixin> ] ?
       )
    } OR @<EntityToFeatureOrDiseaseQualifiers>
)

<FrequencyQuantifier> {
    (  $<FrequencyQuantifier_tes> (  &<RelationshipQuantifier_tes> ;
          rdf:type [ <RelationshipQuantifier> ] ? ;
          <has_count> @metatype:Integer ? ;
          <has_total> @metatype:Integer ? ;
          <has_quotient> @metatype:Double ? ;
          <has_percentage> @metatype:Double ?
       ) ;
       rdf:type [ <FrequencyQuantifier> ] ?
    )
}

<FrequencyValue> CLOSED {
    (  $<FrequencyValue_tes> (  &<Attribute_tes> ;
          rdf:type [ <Attribute> ] ?
       ) ;
       rdf:type [ <FrequencyValue> ]
    )
}

<FunctionalAssociation>  (
    CLOSED {
       (  $<FunctionalAssociation_tes> (  &<Association_tes> ;
             rdf:type [ OBAN:association ] ? ;
             <subject> @<MacromolecularMachine> ;
             <object> @<GeneOntologyClass>
          ) ;
          rdf:type [ <FunctionalAssociation> ]
       )
    } OR @<GeneToGoTermAssociation> OR @<MacromolecularMachineToBiologicalProcessAssociation> OR
    @<MacromolecularMachineToCellularComponentAssociation> OR @<MacromolecularMachineToMolecularActivityAssociation>
)

<Gene> CLOSED {
    (  $<Gene_tes> (  &<GeneOrGeneProduct_tes> ;
          rdf:type [ <GeneOrGeneProduct> ] ? ;
          OBO:RO_0002435 @<Gene> * ;
          OBO:RO_0002205 @<GeneProduct> * ;
          WD:P2293 @<DiseaseOrPhenotypicFeature> *
       ) ;
       rdf:type [ OBO:SO_0000704 ]
    )
}

<GeneAsAModelOfDiseaseAssociation> CLOSED {
    (  $<GeneAsAModelOfDiseaseAssociation_tes> (  &<GeneToDiseaseAssociation_tes> ;
          rdf:type [ <http://semanticscience.org/resource/SIO_000983> ] ? ;
          &<ModelToDiseaseMixin_tes> ;
          rdf:type [ <ModelToDiseaseMixin> ] ? ;
          &<EntityToDiseaseAssociation_tes> ;
          rdf:type [ <EntityToDiseaseAssociation> ] ? ;
          <subject> @<GeneOrGeneProduct>
       ) ;
       rdf:type [ <GeneAsAModelOfDiseaseAssociation> ]
    )
}

<GeneFamily> CLOSED {
    (  $<GeneFamily_tes> (  &<MolecularEntity_tes> ;
          rdf:type [ <http://semanticscience.org/resource/SIO_010341> ] ? ;
          &<GeneGrouping_tes> ;
          rdf:type [ <GeneGrouping> ] ?
       ) ;
       rdf:type [ <http://semanticscience.org/resource/SIO_001380> ]
    )
}

<GeneGrouping> {
    (  $<GeneGrouping_tes> rdf:type . * ;
       rdf:type [ <GeneGrouping> ] ?
    )
}

<GeneHasVariantThatContributesToDiseaseAssociation> CLOSED {
    (  $<GeneHasVariantThatContributesToDiseaseAssociation_tes> (  &<GeneToDiseaseAssociation_tes> ;
          rdf:type [ <http://semanticscience.org/resource/SIO_000983> ] ? ;
          <subject> @<GeneOrGeneProduct> ;
          <sequence_variant_qualifier> @<SequenceVariant> ?
       ) ;
       rdf:type [ <GeneHasVariantThatContributesToDiseaseAssociation> ]
    )
}

<GeneOntologyClass> CLOSED {
    (  $<GeneOntologyClass_tes> (  &<OntologyClass_tes> ;
          rdf:type [ <OntologyClass> ] ?
       ) ;
       rdf:type [ <GeneOntologyClass> ]
    )
}

<GeneOrGeneProduct>  (
    CLOSED {
       (  $<GeneOrGeneProduct_tes> (  &<MacromolecularMachine_tes> ;
             rdf:type [ <MacromolecularMachine> ] ? ;
             <in_pathway_with> @<GeneOrGeneProduct> * ;
             <in_complex_with> @<GeneOrGeneProduct> * ;
             <in_cell_population_with> @<GeneOrGeneProduct> * ;
             OBO:RO_0002206 @<AnatomicalEntity> *
          ) ;
          rdf:type [ <GeneOrGeneProduct> ]
       )
    } OR @<Gene> OR @<GeneProduct>
)

<GeneProduct>  (
    CLOSED {
       (  $<GeneProduct_tes> (  &<GeneOrGeneProduct_tes> ;
             rdf:type [ <GeneOrGeneProduct> ] ?
          ) ;
          rdf:type [ WD:Q424689 ]
       )
    } OR @<RNAProduct> OR @<GeneProductIsoform> OR @<Protein>
)

<GeneProductIsoform> {
    (  $<GeneProductIsoform_tes> (  &<GeneProduct_tes> ;
          rdf:type [ WD:Q424689 ] ?
       ) ;
       rdf:type [ <GeneProductIsoform> ]
    )
}

<GeneRegulatoryRelationship> CLOSED {
    (  $<GeneRegulatoryRelationship_tes> (  &<Association_tes> ;
          rdf:type [ OBAN:association ] ? ;
          <subject> @<GeneOrGeneProduct> ;
          <relation> @metatype:Uriorcurie ;
          <object> @<GeneOrGeneProduct>
       ) ;
       rdf:type [ <GeneRegulatoryRelationship> ]
    )
}

<GeneToDiseaseAssociation>  (
    CLOSED {
       (  $<GeneToDiseaseAssociation_tes> (  &<Association_tes> ;
             rdf:type [ OBAN:association ] ? ;
             &<EntityToDiseaseAssociation_tes> ;
             rdf:type [ <EntityToDiseaseAssociation> ] ? ;
             &<GeneToThingAssociation_tes> ;
             rdf:type [ <GeneToThingAssociation> ] ? ;
             <subject> @<GeneOrGeneProduct>
          ) ;
          rdf:type [ <http://semanticscience.org/resource/SIO_000983> ]
       )
    } OR @<GeneAsAModelOfDiseaseAssociation> OR @<GeneHasVariantThatContributesToDiseaseAssociation>
)

<GeneToExpressionSiteAssociation> CLOSED {
    (  $<GeneToExpressionSiteAssociation_tes> (  &<Association_tes> ;
          rdf:type [ OBAN:association ] ? ;
          <subject> @<GeneOrGeneProduct> ;
          <relation> @metatype:Uriorcurie ;
          <object> @<AnatomicalEntity> ;
          <stage_qualifier> @<LifeStage> ? ;
          <quantifier_qualifier> @<OntologyClass> ?
       ) ;
       rdf:type [ <GeneToExpressionSiteAssociation> ]
    )
}

<GeneToGeneAssociation>  (
    @<GeneToGeneHomologyAssociation> OR @<PairwiseGeneToGeneInteraction>
)

<GeneToGeneAssociation_struct> {
    (  $<GeneToGeneAssociation_tes> (  &<Association_tes> ;
          rdf:type [ OBAN:association ] ? ;
          <subject> @<GeneOrGeneProduct> ;
          <object> @<GeneOrGeneProduct>
       ) ;
       rdf:type [ <GeneToGeneAssociation> ]
    )
}

<GeneToGeneHomologyAssociation> CLOSED {
    (  $<GeneToGeneHomologyAssociation_tes> (  &<GeneToGeneAssociation_tes> ;
          rdf:type [ <GeneToGeneAssociation> ] ? ;
          <relation> @metatype:Uriorcurie
       ) ;
       rdf:type [ <GeneToGeneHomologyAssociation> ]
    )
}

<GeneToGeneProductRelationship> CLOSED {
    (  $<GeneToGeneProductRelationship_tes> (  &<SequenceFeatureRelationship_tes> ;
          rdf:type [ <SequenceFeatureRelationship> ] ? ;
          <subject> @<Gene> ;
          <relation> @metatype:Uriorcurie ;
          <object> @<GeneProduct>
       ) ;
       rdf:type [ <GeneToGeneProductRelationship> ]
    )
}

<GeneToGoTermAssociation> CLOSED {
    (  $<GeneToGoTermAssociation_tes> (  &<FunctionalAssociation_tes> ;
          rdf:type [ <FunctionalAssociation> ] ? ;
          <subject> @<MolecularEntity> ;
          <object> @<GeneOntologyClass>
       ) ;
       rdf:type [ <http://bio2rdf.org/wormbase_vocabulary:Gene-GO-Association> ]
    )
}

<GeneToPhenotypicFeatureAssociation> CLOSED {
    (  $<GeneToPhenotypicFeatureAssociation_tes> (  &<Association_tes> ;
          rdf:type [ OBAN:association ] ? ;
          &<EntityToPhenotypicFeatureAssociation_tes> ;
          rdf:type [ <EntityToPhenotypicFeatureAssociation> ] ? ;
          &<GeneToThingAssociation_tes> ;
          rdf:type [ <GeneToThingAssociation> ] ? ;
          <subject> @<GeneOrGeneProduct>
       ) ;
       rdf:type [ <http://bio2rdf.org/wormbase_vocabulary:Gene-Phenotype-Association> ]
    )
}

<GeneToThingAssociation> {
    (  $<GeneToThingAssociation_tes> (  &<Association_tes> ;
          rdf:type [ OBAN:association ] ? ;
          <subject> @<GeneOrGeneProduct>
       ) ;
       rdf:type [ <GeneToThingAssociation> ]
    )
}

<Genome> CLOSED {
    (  $<Genome_tes> (  &<GenomicEntity_tes> ;
          rdf:type [ OBO:SO_0000110 ] ?
       ) ;
       rdf:type [ OBO:SO_0001026 ]
    )
}

<GenomicEntity>  (
    CLOSED {
       (  $<GenomicEntity_tes> (  &<MolecularEntity_tes> ;
             rdf:type [ <http://semanticscience.org/resource/SIO_010341> ] ? ;
             <has_biological_sequence> @<BiologicalSequence> ?
          ) ;
          rdf:type [ OBO:SO_0000110 ]
       )
    } OR @<CodingSequence> OR @<Exon> OR @<Genome> OR @<Genotype> OR @<Haplotype> OR @<MacromolecularMachine> OR @<SequenceVariant>
    OR @<Transcript>
)

<GenomicSequenceLocalization> CLOSED {
    (  $<GenomicSequenceLocalization_tes> (  &<Association_tes> ;
          rdf:type [ OBAN:association ] ? ;
          <subject> @<GenomicEntity> ;
          <object> @<GenomicEntity> ;
          <start_interbase_coordinate> @metatype:String ? ;
          <end_interbase_coordinate> @metatype:String ? ;
          <genome_build> @metatype:String ? ;
          <phase> @metatype:String ?
       ) ;
       rdf:type [ faldo:location ]
    )
}

<Genotype> CLOSED {
    (  $<Genotype_tes> (  &<GenomicEntity_tes> ;
          rdf:type [ OBO:SO_0000110 ] ? ;
          <has_zygosity> @<Zygosity> ?
       ) ;
       rdf:type [ OBO:GENO_0000536 ]
    )
}

<GenotypeToGeneAssociation> CLOSED {
    (  $<GenotypeToGeneAssociation_tes> (  &<Association_tes> ;
          rdf:type [ OBAN:association ] ? ;
          <subject> @<Genotype> ;
          <relation> @metatype:Uriorcurie ;
          <object> @<Gene>
       ) ;
       rdf:type [ <GenotypeToGeneAssociation> ]
    )
}

<GenotypeToGenotypePartAssociation> CLOSED {
    (  $<GenotypeToGenotypePartAssociation_tes> (  &<Association_tes> ;
          rdf:type [ OBAN:association ] ? ;
          <subject> @<Genotype> ;
          <relation> @metatype:Uriorcurie ;
          <object> @<Genotype>
       ) ;
       rdf:type [ <GenotypeToGenotypePartAssociation> ]
    )
}

<GenotypeToPhenotypicFeatureAssociation> CLOSED {
    (  $<GenotypeToPhenotypicFeatureAssociation_tes> (  &<Association_tes> ;
          rdf:type [ OBAN:association ] ? ;
          &<EntityToPhenotypicFeatureAssociation_tes> ;
          rdf:type [ <EntityToPhenotypicFeatureAssociation> ] ? ;
          &<GenotypeToThingAssociation_tes> ;
          rdf:type [ <GenotypeToThingAssociation> ] ? ;
          <subject> @<Genotype> ;
          <relation> @metatype:Uriorcurie
       ) ;
       rdf:type [ <GenotypeToPhenotypicFeatureAssociation> ]
    )
}

<GenotypeToThingAssociation> {
    (  $<GenotypeToThingAssociation_tes> (  &<Association_tes> ;
          rdf:type [ OBAN:association ] ? ;
          <subject> @<Genotype>
       ) ;
       rdf:type [ <GenotypeToThingAssociation> ]
    )
}

<GenotypeToVariantAssociation> CLOSED {
    (  $<GenotypeToVariantAssociation_tes> (  &<Association_tes> ;
          rdf:type [ OBAN:association ] ? ;
          <subject> @<Genotype> ;
          <relation> @metatype:Uriorcurie ;
          <object> @<SequenceVariant>
       ) ;
       rdf:type [ <GenotypeToVariantAssociation> ]
    )
}

<GenotypicSex> CLOSED {
    (  $<GenotypicSex_tes> (  &<BiologicalSex_tes> ;
          rdf:type [ <BiologicalSex> ] ?
       ) ;
       rdf:type [ <GenotypicSex> ]
    )
}

<GeographicLocation>  (
    CLOSED {
       (  $<GeographicLocation_tes> (  &<PlanetaryEntity_tes> ;
             rdf:type [ <PlanetaryEntity> ] ? ;
             <http://www.w3.org/2003/01/geo/wgs84_poslat> @metatype:Float ? ;
             <http://www.w3.org/2003/01/geo/wgs84_poslong> @metatype:Float ?
          ) ;
          rdf:type [ <GeographicLocation> ]
       )
    } OR @<GeographicLocationAtTime>
)

<GeographicLocationAtTime> CLOSED {
    (  $<GeographicLocationAtTime_tes> (  &<GeographicLocation_tes> ;
          rdf:type [ <GeographicLocation> ] ? ;
          <timepoint> @<TimeType> ?
       ) ;
       rdf:type [ <GeographicLocationAtTime> ]
    )
}

<GrossAnatomicalStructure> CLOSED {
    (  $<GrossAnatomicalStructure_tes> (  &<AnatomicalEntity_tes> ;
          rdf:type [ <http://semanticscience.org/resource/SIO_010046> ] ?
       ) ;
       rdf:type [ OBO:UBERON_0010000 ]
    )
}

<Haplotype> CLOSED {
    (  $<Haplotype_tes> (  &<GenomicEntity_tes> ;
          rdf:type [ OBO:SO_0000110 ] ?
       ) ;
       rdf:type [ OBO:GENO_0000871 ]
    )
}

<IndividualOrganism>  (
    CLOSED {
       (  $<IndividualOrganism_tes> (  &<OrganismalEntity_tes> ;
             rdf:type [ WD:Q7239 ] ? ;
             &<ThingWithTaxon_tes> ;
             rdf:type [ <ThingWithTaxon> ] ? ;
             OBO:RO_0002162 @<OrganismTaxon> *
          ) ;
          rdf:type [ <http://semanticscience.org/resource/SIO_010000> ]
       )
    } OR @<Case>
)

<InformationContentEntity>  (
    @<ConfidenceLevel> OR @<EvidenceType> OR @<Publication>
)

<InformationContentEntity_struct> {
    (  $<InformationContentEntity_tes> (  &<NamedThing_tes> ;
          rdf:type [ WD:Q35120 ] ?
       ) ;
       rdf:type [ OBO:IAO_0000030 ]
    )
}

<LifeStage> CLOSED {
    (  $<LifeStage_tes> (  &<OrganismalEntity_tes> ;
          rdf:type [ WD:Q7239 ] ? ;
          &<ThingWithTaxon_tes> ;
          rdf:type [ <ThingWithTaxon> ] ? ;
          OBO:RO_0002162 @<OrganismTaxon> *
       ) ;
       rdf:type [ <LifeStage> ]
    )
}

<MacromolecularComplex> CLOSED {
    (  $<MacromolecularComplex_tes> (  &<MacromolecularMachine_tes> ;
          rdf:type [ <MacromolecularMachine> ] ?
       ) ;
       rdf:type [ <http://semanticscience.org/resource/SIO_010046> ]
    )
}

<MacromolecularMachine>  (
    CLOSED {
       (  $<MacromolecularMachine_tes> (  &<GenomicEntity_tes> ;
             rdf:type [ OBO:SO_0000110 ] ? ;
             <name> @<SymbolType>
          ) ;
          rdf:type [ <MacromolecularMachine> ]
       )
    } OR @<GeneOrGeneProduct> OR @<MacromolecularComplex>
)

<MacromolecularMachineToBiologicalProcessAssociation> CLOSED {
    (  $<MacromolecularMachineToBiologicalProcessAssociation_tes> (  &<FunctionalAssociation_tes> ;
          rdf:type [ <FunctionalAssociation> ] ? ;
          <object> @<BiologicalProcess>
       ) ;
       rdf:type [ <MacromolecularMachineToBiologicalProcessAssociation> ]
    )
}

<MacromolecularMachineToCellularComponentAssociation> CLOSED {
    (  $<MacromolecularMachineToCellularComponentAssociation_tes> (  &<FunctionalAssociation_tes> ;
          rdf:type [ <FunctionalAssociation> ] ? ;
          <object> @<CellularComponent>
       ) ;
       rdf:type [ <MacromolecularMachineToCellularComponentAssociation> ]
    )
}

<MacromolecularMachineToMolecularActivityAssociation> CLOSED {
    (  $<MacromolecularMachineToMolecularActivityAssociation_tes> (  &<FunctionalAssociation_tes> ;
          rdf:type [ <FunctionalAssociation> ] ? ;
          <object> @<MolecularActivity>
       ) ;
       rdf:type [ <MacromolecularMachineToMolecularActivityAssociation> ]
    )
}

<MaterialSample> CLOSED {
    (  $<MaterialSample_tes> (  &<NamedThing_tes> ;
          rdf:type [ WD:Q35120 ] ? ;
          &<SubjectOfInvestigation_tes> ;
          rdf:type [ <SubjectOfInvestigation> ] ? ;
          &<PhysicalEntity_tes> ;
          rdf:type [ <PhysicalEntity> ] ? ;
          <has_attribute> @<Attribute> *
       ) ;
       rdf:type [ <MaterialSample> ]
    )
}

<MaterialSampleDerivationAssociation> CLOSED {
    (  $<MaterialSampleDerivationAssociation_tes> (  &<Association_tes> ;
          rdf:type [ OBAN:association ] ? ;
          <subject> @<MaterialSample> ;
          <relation> @metatype:Uriorcurie ;
          <object> @<NamedThing>
       ) ;
       rdf:type [ <MaterialSampleDerivationAssociation> ]
    )
}

<MaterialSampleToDiseaseOrPhenotypicFeatureAssociation> CLOSED {
    (  $<MaterialSampleToDiseaseOrPhenotypicFeatureAssociation_tes> (  &<Association_tes> ;
          rdf:type [ OBAN:association ] ? ;
          &<MaterialSampleToThingAssociation_tes> ;
          rdf:type [ <MaterialSampleToThingAssociation> ] ? ;
          &<ThingToDiseaseOrPhenotypicFeatureAssociation_tes> ;
          rdf:type [ <ThingToDiseaseOrPhenotypicFeatureAssociation> ] ?
       ) ;
       rdf:type [ <MaterialSampleToDiseaseOrPhenotypicFeatureAssociation> ]
    )
}

<MaterialSampleToThingAssociation> {
    (  $<MaterialSampleToThingAssociation_tes> (  &<Association_tes> ;
          rdf:type [ OBAN:association ] ? ;
          <subject> @<MaterialSample>
       ) ;
       rdf:type [ <MaterialSampleToThingAssociation> ]
    )
}

<Metabolite> CLOSED {
    (  $<Metabolite_tes> (  &<ChemicalSubstance_tes> ;
          rdf:type [ <http://semanticscience.org/resource/SIO_010004> ] ?
       ) ;
       rdf:type [ OBO:CHEBI_25212 ]
    )
}

<MicroRNA> CLOSED {
    (  $<MicroRNA_tes> (  &<NoncodingRNAProduct_tes> ;
          rdf:type [ <http://semanticscience.org/resource/SIO_001235> ] ?
       ) ;
       rdf:type [ <http://semanticscience.org/resource/SIO_001397> ]
    )
}

<ModelToDiseaseMixin> {
    (  $<ModelToDiseaseMixin_tes> (  <subject> @<NamedThing> ;
          <relation> @metatype:Uriorcurie
       ) ;
       rdf:type [ <ModelToDiseaseMixin> ] ?
    )
}

<MolecularActivity> CLOSED {
    (  $<MolecularActivity_tes> (  &<BiologicalProcessOrActivity_tes> ;
          rdf:type [ <BiologicalProcessOrActivity> ] ? ;
          &<Occurrent_tes> ;
          rdf:type [ OBO:BFO_0000003 ] ? ;
          <has_input> @<ChemicalSubstance> * ;
          <has_output> @<ChemicalSubstance> * ;
          <enabled_by> @<MacromolecularMachine> *
       ) ;
       rdf:type [ OBO:GO_0003674 ]
    )
}

<MolecularEntity>  (
    CLOSED {
       (  $<MolecularEntity_tes> (  &<BiologicalEntity_tes> ;
             rdf:type [ WD:Q28845870 ] ? ;
             &<ThingWithTaxon_tes> ;
             rdf:type [ <ThingWithTaxon> ] ? ;
             &<PhysicalEntity_tes> ;
             rdf:type [ <PhysicalEntity> ] ? ;
             OBO:RO_0002436 @<MolecularEntity> * ;
             <affects_abundance_of> @<MolecularEntity> * ;
             <increases_abundance_of> @<MolecularEntity> * ;
             <decreases_abundance_of> @<MolecularEntity> * ;
             <affects_activity_of> @<MolecularEntity> * ;
             <increases_activity_of> @<MolecularEntity> * ;
             <decreases_activity_of> @<MolecularEntity> * ;
             <affects_expression_of> @<GenomicEntity> * ;
             <increases_expression_of> @<GenomicEntity> * ;
             <decreases_expression_of> @<GenomicEntity> * ;
             <affects_folding_of> @<MolecularEntity> * ;
             <increases_folding_of> @<MolecularEntity> * ;
             <decreases_folding_of> @<MolecularEntity> * ;
             <affects_localization_of> @<MolecularEntity> * ;
             <increases_localization_of> @<MolecularEntity> * ;
             <decreases_localization_of> @<MolecularEntity> * ;
             <affects_metabolic_processing_of> @<MolecularEntity> * ;
             <increases_metabolic_processing_of> @<MolecularEntity> * ;
             <decreases_metabolic_processing_of> @<MolecularEntity> * ;
             <affects_molecular_modification_of> @<MolecularEntity> * ;
             <increases_molecular_modification_of> @<MolecularEntity> * ;
             <decreases_molecular_modification_of> @<MolecularEntity> * ;
             <affects_synthesis_of> @<MolecularEntity> * ;
             <increases_synthesis_of> @<MolecularEntity> * ;
             <decreases_synthesis_of> @<MolecularEntity> * ;
             <affects_degradation_of> @<MolecularEntity> * ;
             <increases_degradation_of> @<MolecularEntity> * ;
             <decreases_degradation_of> @<MolecularEntity> * ;
             <affects_mutation_rate_of> @<GenomicEntity> * ;
             <increases_mutation_rate_of> @<GenomicEntity> * ;
             <decreases_mutation_rate_of> @<GenomicEntity> * ;
             <affects_response_to> @<MolecularEntity> * ;
             <increases_response_to> @<MolecularEntity> * ;
             <decreases_response_to> @<MolecularEntity> * ;
             <affects_splicing_of> @<Transcript> * ;
             <increases_splicing_of> @<Transcript> * ;
             <decreases_splicing_of> @<Transcript> * ;
             <affects_stability_of> @<MolecularEntity> * ;
             <increases_stability_of> @<MolecularEntity> * ;
             <decreases_stability_of> @<MolecularEntity> * ;
             <affects_transport_of> @<MolecularEntity> * ;
             <increases_transport_of> @<MolecularEntity> * ;
             <decreases_transport_of> @<MolecularEntity> * ;
             <affects_secretion_of> @<MolecularEntity> * ;
             <increases_secretion_of> @<MolecularEntity> * ;
             <decreases_secretion_of> @<MolecularEntity> * ;
             <affects_uptake_of> @<MolecularEntity> * ;
             <increases_uptake_of> @<MolecularEntity> * ;
             <decreases_uptake_of> @<MolecularEntity> * ;
             OBO:RO_0002448 @<MolecularEntity> * ;
             OBO:RO_0002607 @<DiseaseOrPhenotypicFeature> * ;
             OBO:RO_0002162 @<OrganismTaxon> * ;
             OBO:RO_0002450 @<MolecularEntity> * ;
             OBO:RO_0002449 @<MolecularEntity> *
          ) ;
          rdf:type [ <http://semanticscience.org/resource/SIO_010341> ]
       )
    } OR @<ChemicalSubstance> OR @<GeneFamily> OR @<GenomicEntity>
)

<NamedThing>  (
    CLOSED {
       (  $<NamedThing_tes> (  rdfs:label @<LabelType> ;
             rdfs:subClassOf @<IriType> + ;
             owl:ObjectProperty @<NamedThing> * ;
             OBO:RO_0002434 @<NamedThing> * ;
             <node_property> @metatype:String ? ;
             <iri> @<IriType> ? ;
             <synonym> @<LabelType> * ;
             <full_name> @<LabelType> ? ;
             dcterms:description @<NarrativeText> ? ;
             <systematic_synonym> @<LabelType> * ;
             WD:P129 @<NamedThing> * ;
             SEMMEDDB:AFFECTS @<NamedThing> * ;
             SEMMEDDB:DISRUPTS @<NamedThing> * ;
             OBO:RO_HOM0000001 @<NamedThing> * ;
             OBO:RO_HOM0000011 @<NamedThing> * ;
             OBO:RO_HOM0000017 @<NamedThing> * ;
             OBO:RO_HOM0000018 @<NamedThing> * ;
             SEMMEDDB:COEXISTS_WITH @<NamedThing> * ;
             OBO:RO_00002325 @<NamedThing> * ;
             <affects_risk_for> @<NamedThing> * ;
             SEMMEDDB:PREDISPOSES @<NamedThing> * ;
             OBO:RO_0002326 @<NamedThing> * ;
             OBO:RO_0002410 @<NamedThing> * ;
             OBO:RO_0002599 @<NamedThing> * ;
             OBO:BFO_0000066 @<NamedThing> * ;
             OBO:RO_0001025 @<NamedThing> * ;
             OBO:RO_0001015 @<NamedThing> * ;
             OBO:RO_0003301 @<NamedThing> * ;
             OBO:RO_0002131 @<NamedThing> * ;
             OBO:BFO_0000051 @<NamedThing> * ;
             OBO:BFO_0000050 @<NamedThing> * ;
             OBO:RO_0000056 @<Occurrent> * ;
             OBO:RO_0002331 @<Occurrent> * ;
             OBO:RO_0002215 @<Occurrent> * ;
             OBO:RO_0001001 @<NamedThing> * ;
             OBO:RO_0001000 @<NamedThing> * ;
             SEMMEDDB:MANIFESTATION_OF @<Disease> * ;
             OBO:RO_0003000 @<NamedThing> * ;
             owl:equivalentClass @<NamedThing> * ;
             rdf:type @metatype:String ? ;
             dcterms:created @metatype:Date ? ;
             <update_date> @metatype:Date ? ;
             <http://www.w3.org/2003/01/geo/wgs84_poslat> @metatype:Float ? ;
             <http://www.w3.org/2003/01/geo/wgs84_poslong> @metatype:Float ? ;
             WD:P274 @<ChemicalFormulaValue> ? ;
             <has_count> @metatype:Integer ? ;
             <has_total> @metatype:Integer ? ;
             <has_quotient> @metatype:Double ? ;
             <has_percentage> @metatype:Double ? ;
             <timepoint> @<TimeType> ? ;
             <has_biological_sequence> @<BiologicalSequence> ? ;
             <has_molecular_consequence> @<OntologyClass> * ;
             <has_gene> @<Gene> ? ;
             <has_zygosity> @<Zygosity> ? ;
             <filler> @<NamedThing> ? ;
             <phase> @metatype:String ? ;
             <genome_build> @metatype:String ? ;
             <interbase_coordinate> @metatype:String ? ;
             <start_interbase_coordinate> @metatype:String ? ;
             <end_interbase_coordinate> @metatype:String ?
          ) ;
          rdf:type [ WD:Q35120 ]
       )
    } OR @<AdministrativeEntity> OR @<BiologicalEntity> OR @<ClinicalEntity> OR @<DataFile> OR @<DataSet> OR @<Device> OR
    @<InformationContentEntity> OR @<MaterialSample> OR @<Occurrent> OR @<OntologyClass> OR @<PhysicalEntity> OR @<PlanetaryEntity>
)

<NoncodingRNAProduct>  (
    CLOSED {
       (  $<NoncodingRNAProduct_tes> (  &<RNAProduct_tes> ;
             rdf:type [ OBO:CHEBI_33697 ] ?
          ) ;
          rdf:type [ <http://semanticscience.org/resource/SIO_001235> ]
       )
    } OR @<MicroRNA>
)

<Occurrent>  (
    CLOSED {
       (  $<Occurrent_tes> (  &<NamedThing_tes> ;
             rdf:type [ WD:Q35120 ] ? ;
             OBO:RO_0002211 @<Occurrent> * ;
             OBO:RO_0000057 @<NamedThing> * ;
             OBO:RO_0002233 @<NamedThing> * ;
             OBO:RO_0002234 @<NamedThing> * ;
             OBO:BFO_0000063 @<Occurrent> * ;
             OBO:RO_0002213 @<Occurrent> * ;
             OBO:RO_0002212 @<Occurrent> * ;
             OBO:RO_0002333 @<BiologicalProcessOrActivity> *
          ) ;
          rdf:type [ OBO:BFO_0000003 ]
       )
    } OR @<ActivityAndBehavior> OR @<Phenomenon> OR @<Procedure>
)

<Onset> CLOSED {
    (  $<Onset_tes> (  &<Attribute_tes> ;
          rdf:type [ <Attribute> ] ?
       ) ;
       rdf:type [ OBO:HP_0003674 ]
    )
}

<OntologyClass>  (
    CLOSED {
       (  $<OntologyClass_tes> (  &<NamedThing_tes> ;
             rdf:type [ WD:Q35120 ] ? ;
             rdfs:subClassOf @<IriType> *
          ) ;
          rdf:type [ <OntologyClass> ]
       )
    } OR @<GeneOntologyClass> OR @<OrganismTaxon> OR @<RelationshipType>
)

<OrganismTaxon> CLOSED {
    (  $<OrganismTaxon_tes> (  &<OntologyClass_tes> ;
          rdf:type [ <OntologyClass> ] ?
       ) ;
       rdf:type [ WD:Q16521 ]
    )
}

<OrganismalEntity>  (
    @<AnatomicalEntity> OR @<CellLine> OR @<IndividualOrganism> OR @<LifeStage> OR @<PopulationOfIndividualOrganisms>
)

<OrganismalEntity_struct> {
    (  $<OrganismalEntity_tes> (  &<BiologicalEntity_tes> ;
          rdf:type [ WD:Q28845870 ] ?
       ) ;
       rdf:type [ WD:Q7239 ]
    )
}

<PairwiseGeneToGeneInteraction> CLOSED {
    (  $<PairwiseGeneToGeneInteraction_tes> (  &<GeneToGeneAssociation_tes> ;
          rdf:type [ <GeneToGeneAssociation> ] ? ;
          &<PairwiseInteractionAssociation_tes> ;
          rdf:type [ <PairwiseInteractionAssociation> ] ? ;
          <relation> @metatype:Uriorcurie
       ) ;
       rdf:type [ <PairwiseGeneToGeneInteraction> ]
    )
}

<PairwiseInteractionAssociation> {
    (  $<PairwiseInteractionAssociation_tes> (  &<Association_tes> ;
          rdf:type [ OBAN:association ] ? ;
          <subject> @<MolecularEntity> ;
          <relation> @metatype:Uriorcurie ;
          <object> @<MolecularEntity> ;
          <interacting_molecules_category> @<OntologyClass> ?
       ) ;
       rdf:type [ <PairwiseInteractionAssociation> ]
    )
}

<PathognomonicityQuantifier> {
    (  $<PathognomonicityQuantifier_tes> (  &<SpecificityQuantifier_tes> ;
          rdf:type [ <SpecificityQuantifier> ] ?
       ) ;
       rdf:type [ <PathognomonicityQuantifier> ] ?
    )
}

<Pathway> CLOSED {
    (  $<Pathway_tes> (  &<BiologicalProcess_tes> ;
          rdf:type [ OBO:GO_0008150 ] ?
       ) ;
       rdf:type [ OBO:GO_0007165 ]
    )
}

<Phenomenon> CLOSED {
    (  $<Phenomenon_tes> (  &<Occurrent_tes> ;
          rdf:type [ OBO:BFO_0000003 ] ?
       ) ;
       rdf:type [ <Phenomenon> ]
    )
}

<PhenotypicFeature> CLOSED {
    (  $<PhenotypicFeature_tes> (  &<DiseaseOrPhenotypicFeature_tes> ;
          rdf:type [ <DiseaseOrPhenotypicFeature> ] ?
       ) ;
       rdf:type [ OBO:UPHENO_0001001 ]
    )
}

<PhenotypicSex> CLOSED {
    (  $<PhenotypicSex_tes> (  &<BiologicalSex_tes> ;
          rdf:type [ <BiologicalSex> ] ?
       ) ;
       rdf:type [ <PhenotypicSex> ]
    )
}

<PhysicalEntity> CLOSED {
    (  $<PhysicalEntity_tes> (  &<NamedThing_tes> ;
          rdf:type [ WD:Q35120 ] ?
       ) ;
       rdf:type [ <PhysicalEntity> ]
    )
}

<PhysiologicalProcess> CLOSED {
    (  $<PhysiologicalProcess_tes> (  &<BiologicalProcess_tes> ;
          rdf:type [ OBO:GO_0008150 ] ?
       ) ;
       rdf:type [ <PhysiologicalProcess> ]
    )
}

<PlanetaryEntity>  (
    CLOSED {
       (  $<PlanetaryEntity_tes> (  &<NamedThing_tes> ;
             rdf:type [ WD:Q35120 ] ?
          ) ;
          rdf:type [ <PlanetaryEntity> ]
       )
    } OR @<EnvironmentalFeature> OR @<EnvironmentalProcess> OR @<GeographicLocation>
)

<PopulationOfIndividualOrganisms> CLOSED {
    (  $<PopulationOfIndividualOrganisms_tes> (  &<OrganismalEntity_tes> ;
          rdf:type [ WD:Q7239 ] ? ;
          &<ThingWithTaxon_tes> ;
          rdf:type [ <ThingWithTaxon> ] ? ;
          OBO:RO_0002162 @<OrganismTaxon> *
       ) ;
       rdf:type [ <http://semanticscience.org/resource/SIO_001061> ]
    )
}

<PopulationToPopulationAssociation> CLOSED {
    (  $<PopulationToPopulationAssociation_tes> (  &<Association_tes> ;
          rdf:type [ OBAN:association ] ? ;
          <subject> @<PopulationOfIndividualOrganisms> ;
          <relation> @metatype:Uriorcurie ;
          <object> @<PopulationOfIndividualOrganisms>
       ) ;
       rdf:type [ <PopulationToPopulationAssociation> ]
    )
}

<Procedure> CLOSED {
    (  $<Procedure_tes> (  &<Occurrent_tes> ;
          rdf:type [ OBO:BFO_0000003 ] ?
       ) ;
       rdf:type [ <Procedure> ]
    )
}

<Protein>  (
    CLOSED {
       (  $<Protein_tes> (  &<GeneProduct_tes> ;
             rdf:type [ WD:Q424689 ] ?
          ) ;
          rdf:type [ OBO:PR_000000001 ]
       )
    } OR @<ProteinIsoform>
)

<ProteinIsoform> CLOSED {
    (  $<ProteinIsoform_tes> (  &<Protein_tes> ;
          rdf:type [ OBO:PR_000000001 ] ? ;
          &<GeneProductIsoform_tes> ;
          rdf:type [ <GeneProductIsoform> ] ?
       ) ;
       rdf:type [ <ProteinIsoform> ]
    )
}

<Provider> CLOSED {
    (  $<Provider_tes> (  &<AdministrativeEntity_tes> ;
          rdf:type [ <AdministrativeEntity> ] ?
       ) ;
       rdf:type [ <Provider> ]
    )
}

<Publication> CLOSED {
    (  $<Publication_tes> (  &<InformationContentEntity_tes> ;
          rdf:type [ OBO:IAO_0000030 ] ?
       ) ;
       rdf:type [ OBO:IAO_0000311 ]
    )
}

<QuantityValue> CLOSED {
    (  $<QuantityValue_tes> (  &<AbstractEntity_tes> ;
          rdf:type [ <AbstractEntity> ] ? ;
          <has_unit> @<Unit> ? ;
          <has_numeric_value> @metatype:Double ?
       ) ;
       rdf:type [ <QuantityValue> ] ?
    )
}

<RelationshipQuantifier>  (
    @<FrequencyQuantifier> OR @<SensitivityQuantifier> OR @<SpecificityQuantifier>
)

<RelationshipQuantifier_struct> {
    (  $<RelationshipQuantifier_tes> rdf:type . * ;
       rdf:type [ <RelationshipQuantifier> ] ?
    )
}

<RelationshipType> CLOSED {
    (  $<RelationshipType_tes> (  &<OntologyClass_tes> ;
          rdf:type [ <OntologyClass> ] ?
       ) ;
       rdf:type [ <RelationshipType> ]
    )
}

<RNAProduct>  (
    CLOSED {
       (  $<RNAProduct_tes> (  &<GeneProduct_tes> ;
             rdf:type [ WD:Q424689 ] ?
          ) ;
          rdf:type [ OBO:CHEBI_33697 ]
       )
    } OR @<RNAProductIsoform> OR @<NoncodingRNAProduct>
)

<RNAProductIsoform> CLOSED {
    (  $<RNAProductIsoform_tes> (  &<RNAProduct_tes> ;
          rdf:type [ OBO:CHEBI_33697 ] ? ;
          &<GeneProductIsoform_tes> ;
          rdf:type [ <GeneProductIsoform> ] ?
       ) ;
       rdf:type [ <RNAProductIsoform> ]
    )
}

<SensitivityQuantifier> {
    (  $<SensitivityQuantifier_tes> (  &<RelationshipQuantifier_tes> ;
          rdf:type [ <RelationshipQuantifier> ] ?
       ) ;
       rdf:type [ <SensitivityQuantifier> ] ?
    )
}

<SequenceFeatureRelationship>  (
    CLOSED {
       (  $<SequenceFeatureRelationship_tes> (  &<Association_tes> ;
             rdf:type [ OBAN:association ] ? ;
             <subject> @<GenomicEntity> ;
             <object> @<GenomicEntity>
          ) ;
          rdf:type [ <SequenceFeatureRelationship> ]
       )
    } OR @<ExonToTranscriptRelationship> OR @<GeneToGeneProductRelationship> OR @<TranscriptToGeneRelationship>
)

<SequenceVariant> CLOSED {
    (  $<SequenceVariant_tes> (  &<GenomicEntity_tes> ;
          rdf:type [ OBO:SO_0000110 ] ? ;
          <has_biological_sequence> @<BiologicalSequence> ? ;
          <has_gene> @<Gene> *
       ) ;
       rdf:type [ OBO:GENO_0000002 ]
    )
}

<SequenceVariantModulatesTreatmentAssociation> {
    (  $<SequenceVariantModulatesTreatmentAssociation_tes> (  &<Association_tes> ;
          rdf:type [ OBAN:association ] ? ;
          <subject> @<SequenceVariant> ;
          <object> @<Treatment>
       ) ;
       rdf:type [ <SequenceVariantModulatesTreatmentAssociation> ]
    )
}

<SeverityValue> CLOSED {
    (  $<SeverityValue_tes> (  &<Attribute_tes> ;
          rdf:type [ <Attribute> ] ?
       ) ;
       rdf:type [ <SeverityValue> ]
    )
}

<SourceFile> CLOSED {
    (  $<SourceFile_tes> (  &<DataFile_tes> ;
          rdf:type [ OBO:EFO_0004095 ] ? ;
          pav:version @metatype:String ? ;
          pav:retrievedOn @metatype:Date ?
       ) ;
       rdf:type [ <SourceFile> ]
    )
}

<SpecificityQuantifier>  (
    {
       (  $<SpecificityQuantifier_tes> (  &<RelationshipQuantifier_tes> ;
             rdf:type [ <RelationshipQuantifier> ] ?
          ) ;
          rdf:type [ <SpecificityQuantifier> ] ?
       )
    } OR @<PathognomonicityQuantifier>
)

<SubjectOfInvestigation> {
    (  $<SubjectOfInvestigation_tes> rdf:type . * ;
       rdf:type [ <SubjectOfInvestigation> ] ?
    )
}

<ThingToDiseaseOrPhenotypicFeatureAssociation> {
    (  $<ThingToDiseaseOrPhenotypicFeatureAssociation_tes> (  &<Association_tes> ;
          rdf:type [ OBAN:association ] ? ;
          <object> @<DiseaseOrPhenotypicFeature>
       ) ;
       rdf:type [ <ThingToDiseaseOrPhenotypicFeatureAssociation> ]
    )
}

<ThingWithTaxon> {
    (  $<ThingWithTaxon_tes> OBO:RO_0002162 @<OrganismTaxon> * ;
       rdf:type [ <ThingWithTaxon> ] ?
    )
}

<Transcript> CLOSED {
    (  $<Transcript_tes> (  &<GenomicEntity_tes> ;
          rdf:type [ OBO:SO_0000110 ] ?
       ) ;
       rdf:type [ OBO:SO_0000673 ]
    )
}

<TranscriptToGeneRelationship> CLOSED {
    (  $<TranscriptToGeneRelationship_tes> (  &<SequenceFeatureRelationship_tes> ;
          rdf:type [ <SequenceFeatureRelationship> ] ? ;
          <subject> @<Transcript> ;
          <object> @<Gene>
       ) ;
       rdf:type [ <TranscriptToGeneRelationship> ]
    )
}

<Treatment> CLOSED {
    (  $<Treatment_tes> (  &<Environment_tes> ;
          rdf:type [ <http://semanticscience.org/resource/SIO_000955> ] ? ;
          OBO:RO_0002606 @<DiseaseOrPhenotypicFeature> + ;
          <has_exposure_parts> @<DrugExposure> +
       ) ;
       rdf:type [ OBO:OGMS_0000090 ]
    )
}

<VariantToDiseaseAssociation> CLOSED {
    (  $<VariantToDiseaseAssociation_tes> (  &<Association_tes> ;
          rdf:type [ OBAN:association ] ? ;
          &<VariantToThingAssociation_tes> ;
          rdf:type [ <VariantToThingAssociation> ] ? ;
          &<EntityToDiseaseAssociation_tes> ;
          rdf:type [ <EntityToDiseaseAssociation> ] ? ;
          <subject> @<NamedThing> ;
          <relation> @metatype:Uriorcurie ;
          <object> @<NamedThing>
       ) ;
       rdf:type [ <VariantToDiseaseAssociation> ]
    )
}

<VariantToPhenotypicFeatureAssociation> CLOSED {
    (  $<VariantToPhenotypicFeatureAssociation_tes> (  &<Association_tes> ;
          rdf:type [ OBAN:association ] ? ;
          &<VariantToThingAssociation_tes> ;
          rdf:type [ <VariantToThingAssociation> ] ? ;
          &<EntityToPhenotypicFeatureAssociation_tes> ;
          rdf:type [ <EntityToPhenotypicFeatureAssociation> ] ? ;
          <subject> @<SequenceVariant>
       ) ;
       rdf:type [ <VariantToPhenotypicFeatureAssociation> ]
    )
}

<VariantToPopulationAssociation> CLOSED {
    (  $<VariantToPopulationAssociation_tes> (  &<Association_tes> ;
          rdf:type [ OBAN:association ] ? ;
          &<VariantToThingAssociation_tes> ;
          rdf:type [ <VariantToThingAssociation> ] ? ;
          &<FrequencyQuantifier_tes> ;
          rdf:type [ <FrequencyQuantifier> ] ? ;
          &<FrequencyQualifierMixin_tes> ;
          rdf:type [ <FrequencyQualifierMixin> ] ? ;
          <subject> @<SequenceVariant> ;
          <object> @<PopulationOfIndividualOrganisms> ;
          <has_count> @metatype:Integer ? ;
          <has_total> @metatype:Integer ? ;
          <has_quotient> @metatype:Double ? ;
          <has_percentage> @metatype:Double ?
       ) ;
       rdf:type [ <VariantToPopulationAssociation> ]
    )
}

<VariantToThingAssociation> {
    (  $<VariantToThingAssociation_tes> (  &<Association_tes> ;
          rdf:type [ OBAN:association ] ? ;
          <subject> @<SequenceVariant>
       ) ;
       rdf:type [ <VariantToThingAssociation> ]
    )
}

<Zygosity> CLOSED {
    (  $<Zygosity_tes> (  &<Attribute_tes> ;
          rdf:type [ <Attribute> ] ?
       ) ;
       rdf:type [ OBO:GENO_0000133 ]
    )
}