diff --git a/.bumpversion.cfg b/.bumpversion.cfg
index b9f9c3763..d6a12c902 100644
--- a/.bumpversion.cfg
+++ b/.bumpversion.cfg
@@ -13,6 +13,6 @@ tag = False
 
 [bumpversion:file:src/client/packaging/npm/package.json]
 
-[bumpversion:file:src/client/packaging/pypi/setup.py]
+[bumpversion:file:src/client/packaging/pypi/pyproject.toml]
 
 [bumpversion:file:dev/local/setup.cfg]
diff --git a/.github/workflows/release-helper.yml b/.github/workflows/release-helper.yml
index f6a57a6b3..d4c24dfcc 100644
--- a/.github/workflows/release-helper.yml
+++ b/.github/workflows/release-helper.yml
@@ -57,14 +57,14 @@ jobs:
       - name: Install build dependencies
         run: |
           python -m pip install --upgrade pip
-          pip install wheel twine
+          pip install build wheel twine
       - name: Prepare package
         run: |
           cp src/client/*.py src/client/packaging/pypi/delphi_epidata/
       - name: Create release
         working-directory: src/client/packaging/pypi
         run: |
-          python setup.py sdist bdist_wheel
+          python -m build --sdist --wheel
       - uses: actions/upload-artifact@v2
         with:
           name: delphi_epidata_py
@@ -80,8 +80,8 @@ jobs:
         with:
           user: __token__
           password: ${{ secrets.DELPHI_PYPI_PROD_TOKEN }}
-          packages_dir: src/client/packaging/pypi/dist/
-          skip_existing: true
+          packages-dir: src/client/packaging/pypi/dist/
+          skip-existing: true
           # repository_url: https://test.pypi.org/legacy/
 
   release_js_client:
diff --git a/src/client/packaging/pypi/CHANGELOG.md b/src/client/packaging/pypi/CHANGELOG.md
index ec6534f1a..05316a9bf 100644
--- a/src/client/packaging/pypi/CHANGELOG.md
+++ b/src/client/packaging/pypi/CHANGELOG.md
@@ -3,6 +3,14 @@
 All notable future changes to the `delphi_epidata` python client will be documented in this file.
 The format is based on [Keep a Changelog](http://keepachangelog.com/).
 
+## [4.1.24] - 2024-06-06
+
+### Includes
+- https://github.com/cmu-delphi/delphi-epidata/pull/1470
+
+### Changed
+- Replaced `setup.py` with `pyproject.toml` for package metadata and build configuration.
+
 ## [4.1.23] - 2024-05-31
 
 ### Includes
diff --git a/src/client/packaging/pypi/pyproject.toml b/src/client/packaging/pypi/pyproject.toml
new file mode 100644
index 000000000..2aadda4e9
--- /dev/null
+++ b/src/client/packaging/pypi/pyproject.toml
@@ -0,0 +1,44 @@
+# This file was derived from the PyPA Sample Project
+# https://github.com/pypa/sampleproject
+
+# Guide (user-friendly):
+# https://packaging.python.org/en/latest/guides/writing-pyproject-toml/
+
+# Specification (technical, formal):
+# https://packaging.python.org/en/latest/specifications/pyproject-toml/
+
+
+# Choosing a build backend:
+# https://packaging.python.org/en/latest/tutorials/packaging-projects/#choosing-a-build-backend
+[build-system]
+# A list of packages that are needed to build your package:
+requires = ["setuptools"] # REQUIRED if [build-system] table is used
+# The name of the Python object that frontends will use to perform the build:
+build-backend = "setuptools.build_meta" # If not defined, then legacy behavior can happen.
+
+[project]
+name = "delphi_epidata" # REQUIRED, is the only field that cannot be marked as dynamic.
+version = "4.1.23"
+description = "A programmatic interface to Delphi's Epidata API."
+readme = "README.md"
+license = { file = "LICENSE" }
+authors = [{ name = "David Farrow", email = "dfarrow0@gmail.com" }]
+maintainers = [
+    { name = "Delphi Support", email = "delphi-support+pypi@andrew.cmu.edu" },
+]
+# For a list of valid classifiers, see https://pypi.org/classifiers/
+classifiers = [
+    "License :: OSI Approved :: MIT License",
+    "Programming Language :: Python",
+    "Programming Language :: Python :: 2",
+    "Programming Language :: Python :: 3",
+    "Operating System :: OS Independent",
+    "Intended Audience :: Science/Research",
+    "Natural Language :: English",
+    "Topic :: Scientific/Engineering :: Bio-Informatics",
+]
+dependencies = ["aiohttp", "delphi-utils", "requests>=2.7.0", "tenacity"]
+
+[project.urls]
+"Homepage" = "https://github.com/cmu-delphi/delphi-epidata"
+"Changelog" = "https://github.com/cmu-delphi/delphi-epidata/blob/main/src/client/packaging/pypi/CHANGELOG.md"
diff --git a/src/client/packaging/pypi/setup.py b/src/client/packaging/pypi/setup.py
deleted file mode 100644
index d71ce3db9..000000000
--- a/src/client/packaging/pypi/setup.py
+++ /dev/null
@@ -1,28 +0,0 @@
-import setuptools
-
-with open("README.md", "r") as f:
-    long_description = f.read()
-
-setuptools.setup(
-    name="delphi_epidata",
-    version="4.1.23",
-    author="David Farrow",
-    author_email="dfarrow0@gmail.com",
-    description="A programmatic interface to Delphi's Epidata API.",
-    long_description=long_description,
-    long_description_content_type="text/markdown",
-    url="https://github.com/cmu-delphi/delphi-epidata",
-    project_urls={
-        "Changelog": "https://github.com/cmu-delphi/delphi-epidata/blob/main/src/client/packaging/pypi/CHANGELOG.md",
-    },
-    packages=setuptools.find_packages(),
-    install_requires=["aiohttp", "delphi-utils", "requests>=2.7.0", "tenacity"],
-    classifiers=[
-        "Programming Language :: Python",
-        "License :: OSI Approved :: MIT License",
-        "Operating System :: OS Independent",
-        "Intended Audience :: Science/Research",
-        "Natural Language :: English",
-        "Topic :: Scientific/Engineering :: Bio-Informatics",
-    ],
-)