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TODO
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TODO
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SELEX.py
1) Build a rnds and sequences object
- should have a code sequences method
- should validate sequence lengths, and store initial condition information
2) clean up motif object to store ddg infromation, etc.
- write a __str__ method
3) Get rid of the stupid matrix multiplication, and write a proper cude kernel
Questions:
How do in-vitro compare to 'known' motifs
-What's the correlation with ATAC-seq in the upper rank list
-Do multiple motifs improve our prediction accuracy
-Write a script to find the best motif
How do motifs from different factors do
-Anshul
Can we predict the chemical affinity *without* using ChIP-seq?
TODO:
Find the best base gibbs free energy for each motif
- Maximize marginal rank correlation with ChIP-seq
Optimize over the best motif
Use DNASE instead of ATAC-seq
Include chromatin marks
do a better job with fragment elngth distribution
- use mean fragment length from cross correlation analysis