From 97cae1d5f366ca9ce462ff5ed80e0d68f27c5aac Mon Sep 17 00:00:00 2001 From: Wubing Zhang Date: Thu, 7 Nov 2024 07:51:17 -0800 Subject: [PATCH] binsize to grid.size; spatial_ecotyper to spatialecotyper --- docs/articles/Integration.html | 2 +- docs/articles/SingleSample.html | 2 +- docs/pkgdown.yml | 2 +- docs/reference/AnnotateCells.html | 17 ++++----- docs/reference/ComputeAvgs.html | 18 +++++++-- docs/reference/IntegrateSpatialEcoTyper.html | 2 +- docs/reference/MultiSpatialEcoTyper.html | 2 +- docs/reference/PreprocessST.html | 2 +- docs/reference/RecoverSE.html | 4 +- docs/reference/SpatialEcoTyper.html | 40 ++++++++++---------- docs/search.json | 2 +- man/IntegrateSpatialEcoTyper.Rd | 2 +- man/MultiSpatialEcoTyper.Rd | 2 +- man/RecoverSE.Rd | 4 +- man/SpatialEcoTyper.Rd | 8 ++-- vignettes/Integration.Rmd | 2 +- vignettes/SingleSample.Rmd | 2 +- 17 files changed, 60 insertions(+), 53 deletions(-) diff --git a/docs/articles/Integration.html b/docs/articles/Integration.html index 1f06aa7..a91e8dd 100644 --- a/docs/articles/Integration.html +++ b/docs/articles/Integration.html @@ -500,7 +500,7 @@

Pathologist region annotation minibatch size and reduce the number of cores (ncores) allocated. However, for larger datasets, the minimum memory requirement may remain high. Another option is to -increase the binsize, which reduces the number of spatial +increase the grid.size, which reduces the number of spatial microregions. This can significantly decrease memory usage by downsampling the ST data, potentially excluding many cells from the analysis though.

diff --git a/docs/articles/SingleSample.html b/docs/articles/SingleSample.html index fba2591..29c9284 100644 --- a/docs/articles/SingleSample.html +++ b/docs/articles/SingleSample.html @@ -309,7 +309,7 @@

SE discovery using SpatialEcoTyperminibatch size and reduce the number of cores (ncores) allocated. However, for larger datasets, the minimum memory requirement may remain high. Another option is to -increase the binsize, which reduces the number of spatial +increase the grid.size, which reduces the number of spatial microregions. This can significantly decrease memory usage by downsampling the ST data, potentially excluding many cells from the analysis though.

diff --git a/docs/pkgdown.yml b/docs/pkgdown.yml index 14a55ba..182ceb1 100644 --- a/docs/pkgdown.yml +++ b/docs/pkgdown.yml @@ -8,7 +8,7 @@ articles: Recovery_Spatial: Recovery_Spatial.html SingleSample: SingleSample.html TrainRecoveryModels: TrainRecoveryModels.html -last_built: 2024-11-07T05:38Z +last_built: 2024-11-07T09:12Z urls: reference: https://digitalcytometry.github.io/spatialecotyper/reference article: https://digitalcytometry.github.io/spatialecotyper/articles diff --git a/docs/reference/AnnotateCells.html b/docs/reference/AnnotateCells.html index 0380980..4197b98 100644 --- a/docs/reference/AnnotateCells.html +++ b/docs/reference/AnnotateCells.html @@ -119,12 +119,9 @@

Examples#> HumanMelanomaPatient1__cell_3661 Stroma -874.2712 #> HumanMelanomaPatient1__cell_3663 Stroma -903.6559 obj <- readRDS("Melanoma1_subset_SpatialEcoTyper_results.rds")$obj -#> Warning: cannot open compressed file 'Melanoma1_subset_SpatialEcoTyper_results.rds', probable reason 'No such file or directory' -#> Error in gzfile(file, "rb"): cannot open the connection ## Transfer SE annotations to single cells scmeta <- AnnotateCells(scmeta = scmeta, obj = obj) -#> Error in eval(expr, envir, enclos): object 'obj' not found head(scmeta) #> X Y CellType CellTypeName #> HumanMelanomaPatient1__cell_3655 1894.706 -6367.766 Fibroblast Fibroblasts @@ -133,13 +130,13 @@

Examples#> HumanMelanomaPatient1__cell_3660 1981.600 -6372.266 Fibroblast Fibroblasts #> HumanMelanomaPatient1__cell_3661 1742.939 -6374.851 Fibroblast Fibroblasts #> HumanMelanomaPatient1__cell_3663 1921.683 -6383.309 Fibroblast Fibroblasts -#> Region Dist2Interface -#> HumanMelanomaPatient1__cell_3655 Stroma -883.1752 -#> HumanMelanomaPatient1__cell_3657 Stroma -894.8463 -#> HumanMelanomaPatient1__cell_3658 Stroma -904.1115 -#> HumanMelanomaPatient1__cell_3660 Stroma -907.8909 -#> HumanMelanomaPatient1__cell_3661 Stroma -874.2712 -#> HumanMelanomaPatient1__cell_3663 Stroma -903.6559 +#> Region Dist2Interface SE +#> HumanMelanomaPatient1__cell_3655 Stroma -883.1752 SE5 +#> HumanMelanomaPatient1__cell_3657 Stroma -894.8463 SE7 +#> HumanMelanomaPatient1__cell_3658 Stroma -904.1115 SE7 +#> HumanMelanomaPatient1__cell_3660 Stroma -907.8909 SE7 +#> HumanMelanomaPatient1__cell_3661 Stroma -874.2712 SE0 +#> HumanMelanomaPatient1__cell_3663 Stroma -903.6559 SE5 diff --git a/docs/reference/ComputeAvgs.html b/docs/reference/ComputeAvgs.html index b3a00af..e9a99c4 100644 --- a/docs/reference/ComputeAvgs.html +++ b/docs/reference/ComputeAvgs.html @@ -134,14 +134,24 @@

Examples normdata <- tmpobj[["SCT"]]$data } metadata = readRDS("Melanoma1_subset_SpatialEcoTyper_results.rds")$metadata -#> Warning: cannot open compressed file 'Melanoma1_subset_SpatialEcoTyper_results.rds', probable reason 'No such file or directory' -#> Error in gzfile(file, "rb"): cannot open the connection # Construct cell-type-specific gene expression signatures of SEs avgexprs <- ComputeAvgs(normdata = normdata, scmeta = metadata) -#> Error in eval(expr, envir, enclos): object 'metadata' not found head(avgexprs) -#> Error in h(simpleError(msg, call)): error in evaluating the argument 'x' in selecting a method for function 'head': object 'avgexprs' not found +#> SE5 SE7 SE0 SE4 +#> Fibroblast..PDK4 0.110804267 0.19775972 0.13120621 -0.04927833 +#> Fibroblast..TNFRSF17 0.000000000 0.00000000 0.00000000 0.00000000 +#> Fibroblast..ICAM3 0.000000000 0.00000000 0.00000000 0.00000000 +#> Fibroblast..FAP 0.118792445 -0.13868930 0.05233653 0.03938155 +#> Fibroblast..GZMB -0.031686314 -0.07422975 -0.03297410 0.02567394 +#> Fibroblast..TSC2 -0.001888106 -0.03091562 -0.02679740 -0.02925629 +#> SE6 SE2 SE1 SE3 +#> Fibroblast..PDK4 -0.13236092 -0.17959104 -0.025478747 0.01853931 +#> Fibroblast..TNFRSF17 0.00000000 0.00000000 0.000000000 0.00000000 +#> Fibroblast..ICAM3 0.00000000 0.00000000 0.000000000 0.00000000 +#> Fibroblast..FAP 0.05003947 -0.10671133 0.035710822 -0.07657463 +#> Fibroblast..GZMB 0.00161892 0.02988412 -0.001820212 0.04700560 +#> Fibroblast..TSC2 -0.02869510 -0.05265459 0.117406740 0.13560073 diff --git a/docs/reference/IntegrateSpatialEcoTyper.html b/docs/reference/IntegrateSpatialEcoTyper.html index 6f7a4d2..7d65063 100644 --- a/docs/reference/IntegrateSpatialEcoTyper.html +++ b/docs/reference/IntegrateSpatialEcoTyper.html @@ -137,7 +137,7 @@

Arguments

Examples

- 
# See https://digitalcytometry.github.io/SpatialEcoTyper/docs/articles/Integration.html
+    
# See https://digitalcytometry.github.io/spatialecotyper/docs/articles/Integration.html
 
 
 

diff --git a/docs/reference/MultiSpatialEcoTyper.html b/docs/reference/MultiSpatialEcoTyper.html
index 5b3ab34..352ea85 100644
--- a/docs/reference/MultiSpatialEcoTyper.html
+++ b/docs/reference/MultiSpatialEcoTyper.html
@@ -180,7 +180,7 @@ 
Details
     
Examples

-    
# See https://digitalcytometry.github.io/SpatialEcoTyper/docs/articles/Integration.html
+    
# See https://digitalcytometry.github.io/spatialecotyper/docs/articles/Integration.html
 
 
 

diff --git a/docs/reference/PreprocessST.html b/docs/reference/PreprocessST.html
index 8275418..5d418fc 100644
--- a/docs/reference/PreprocessST.html
+++ b/docs/reference/PreprocessST.html
@@ -143,7 +143,7 @@ 
Examples                     sep = "\t", header = TRUE, row.names = 1)
 processed <- PreprocessST(expdat = scdata, scmeta, X = "X", Y = "Y",
                           min.cells = 3, min.features = 5)
-#> 2024-11-06 21:40:31.278444 Remove 87 genes expressed in fewer than 3 cells
+#> 2024-11-07 01:13:45.324804 Remove 87 genes expressed in fewer than 3 cells
 head(processed$metadata)
 #>                                         X         Y   CellType CellTypeName
 #> HumanMelanomaPatient1__cell_3655 1894.706 -6367.766 Fibroblast  Fibroblasts
diff --git a/docs/reference/RecoverSE.html b/docs/reference/RecoverSE.html
index 739a4e7..1748780 100644
--- a/docs/reference/RecoverSE.html
+++ b/docs/reference/RecoverSE.html
@@ -89,8 +89,8 @@ 
Value

     
Examples

-    
# see https://digitalcytometry.github.io/SpatialEcoTyper_dev/articles/Recovery_scRNA.html
-# see https://digitalcytometry.github.io/SpatialEcoTyper_dev/articles/Recovery_Spatial.html
+    
# see https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_scRNA.html
+# see https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_Spatial.html
 
 
 

diff --git a/docs/reference/SpatialEcoTyper.html b/docs/reference/SpatialEcoTyper.html
index 6233887..ac7fb4f 100644
--- a/docs/reference/SpatialEcoTyper.html
+++ b/docs/reference/SpatialEcoTyper.html
@@ -63,7 +63,7 @@ 
Usage
   iterations = 5,
   minibatch = 5000,
   ncores = 1,
-  binsize = round(radius * 1.4),
+  grid.size = round(radius * 1.4),
   filter.region.by.celltypes = NULL
 )

     

@@ -137,9 +137,9 @@ 
Argumentsbinsize
-
Numeric specifying the bin size for spatial discretization of coordinates. By default,
-this size is determined based on the specified radius (radius*1.4 µm). Increasing the binsize will
+
grid.size

+
Numeric specifying the grid size for spatial discretization of coordinates. By default,
+this size is determined based on the specified radius (radius*1.4 µm). Increasing the grid.size will
 downsample microregions and expedite the analysis, while it might eliminate cells located between bins
 from the SE discovery analysis.

 
@@ -162,7 +162,7 @@ 
Arguments
     
Examples

-    
# See https://digitalcytometry.github.io/SpatialEcoTyper/docs/articles/SingleSample.html
+    
# See https://digitalcytometry.github.io/spatialecotyper/docs/articles/SingleSample.html
 suppressPackageStartupMessages(library(dplyr))
 suppressPackageStartupMessages(library(ggplot2))
 suppressPackageStartupMessages(library(parallel))
@@ -232,27 +232,27 @@ 
Examplesse_results <- SpatialEcoTyper(normdata, scmeta,
                               outprefix = "Melanoma1_subset",
                               radius = 50, ncores = 2)
-#> 2024-11-06 21:40:33.351806 Remove 88 genes expressed in fewer than 5 cells
-#> 2024-11-06 21:40:33.669924 Construct spatial meta cells for each cell type
+#> 2024-11-07 01:13:47.274967 Remove 88 genes expressed in fewer than 5 cells
+#> 2024-11-07 01:13:47.599961 Construct spatial meta cells for each cell type
 #> 		Total spatial microregions: 2315
 #> 		Total spatial meta cells: 7711
-#> 2024-11-06 21:40:44.397087 PCA for each cell type
-#> 2024-11-06 21:40:46.028613 Construct cell-type-specific similarity network
-#> 2024-11-06 21:40:46.687294 Similarity network fusion
-#> 2024-11-06 21:40:46.688753 Normalize networks ...
-#> 2024-11-06 21:40:46.763675 Calculate the local transition matrix ...
-#> 2024-11-06 21:40:47.215871 Perform the diffusion ...
-#> 	2024-11-06 21:40:47.216931 Iteration: 1
-#> 	2024-11-06 21:40:51.881714 Iteration: 2
-#> 	2024-11-06 21:41:14.434246 Iteration: 3
-#> 	2024-11-06 21:41:41.458828 Iteration: 4
-#> 	2024-11-06 21:42:06.833207 Iteration: 5
-#> 2024-11-06 21:42:33.750084 Create Seurat object and perform clustering analysis
+#> 2024-11-07 01:13:57.050384 PCA for each cell type
+#> 2024-11-07 01:13:58.415943 Construct cell-type-specific similarity network
+#> 2024-11-07 01:13:59.127738 Similarity network fusion
+#> 2024-11-07 01:13:59.129295 Normalize networks ...
+#> 2024-11-07 01:13:59.226963 Calculate the local transition matrix ...
+#> 2024-11-07 01:13:59.686673 Perform the diffusion ...
+#> 	2024-11-07 01:13:59.687456 Iteration: 1
+#> 	2024-11-07 01:14:05.423195 Iteration: 2
+#> 	2024-11-07 01:14:21.987019 Iteration: 3
+#> 	2024-11-07 01:14:48.162873 Iteration: 4
+#> 	2024-11-07 01:15:11.952116 Iteration: 5
+#> 2024-11-07 01:15:38.286144 Create Seurat object and perform clustering analysis
 #> Warning: Data is of class dgeMatrix. Coercing to dgCMatrix.
 #> Warning: The default method for RunUMAP has changed from calling Python UMAP via reticulate to the R-native UWOT using the cosine metric
 #> To use Python UMAP via reticulate, set umap.method to 'umap-learn' and metric to 'correlation'
 #> This message will be shown once per session
-#> 2024-11-06 21:42:44.872975 The Seurat object is saved into Melanoma1_subset_SpatialEcoTyper_results.rds
+#> 2024-11-07 01:15:49.269557 The Seurat object is saved into Melanoma1_subset_SpatialEcoTyper_results.rds
 # Extract the Seurat object and updated single-cell metadata
 obj <- se_results$obj # A Seurat object
 obj
diff --git a/docs/search.json b/docs/search.json
index 655435e..41a5473 100644
--- a/docs/search.json
+++ b/docs/search.json
@@ -1 +1 @@
-[{"path":"https://digitalcytometry.github.io/spatialecotyper/LICENSE.html","id":null,"dir":"","previous_headings":"","what":"STANFORD NON-COMMERCIAL SOFTWARE LICENSE AGREEMENT","title":"STANFORD NON-COMMERCIAL SOFTWARE LICENSE AGREEMENT","text":"Board Trustees Leland Stanford Junior University (“Stanford”) provides EcoTyper software code (“Service”) free charge non-commercial use . Use Service commercial entity purpose, including research, prohibited. using Service, agree bound terms Agreement. Please read carefully. agree use Service commercial advantage, course -profit activities. agree use Service behalf organization non-profit organization. Commercial entities wishing use Service contact Stanford University’s Office Technology Licensing reference docket S19-484. SERVICE OFFERED “”, , EXTENT PERMITTED LAW, STANFORD MAKES REPRESENTATIONS EXTENDS WARRANTIES KIND, EITHER EXPRESS IMPLIED. STANFORD SHALL LIABLE CLAIMS DAMAGES RESPECT LOSS CLAIM THIRD PARTY ACCOUNT , ARISING USE SERVICE. HEREBY AGREE DEFEND INDEMNIFY STANFORD, TRUSTEES, EMPLOYEES, OFFICERS, STUDENTS, AGENTS, FACULTY, REPRESENTATIVES, VOLUNTEERS (“STANFORD INDEMNITEES”) LOSS CLAIM ASSERTED STANFORD INDEMNITEES ARISING USE SERVICE. rights expressly granted Agreement reserved retained Stanford licensors content providers. Agreement provides license patent. agree Agreement dispute arising governed laws State California, United States America, applicable agreements negotiated, executed, performed within California. Subject compliance terms conditions set forth Agreement, Stanford grants revocable, non-exclusive, non-transferable right access make use Service.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"overview","dir":"Articles","previous_headings":"","what":"Overview","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"tutorial, illustrate identify conserved spatial ecotypes (SEs) across multiple samples using MultiSpatialEcoTyper function. sample represents single-cell spatial transcriptomics data, including gene expression profile associated single-cell metadata. analyzing single-cell spatial transcriptomics data cancer samples provided Vizgen’s MERSCOPE FFPE Human Immuno-oncology. efficiency, selected subset regions melanoma sample colon cancer sample integrative analysis. can download gene expression profiles single-cell metadata . melanoma sample includes spatial expression data 500 genes across 27,907 cells, colon cancer sample contains data 38,080 cells. samples, cells categorized ten distinct cell types: B cells, CD4+ T cells, CD8+ T cells, NK cells, plasma cells, macrophages, dendritic cells (DC), fibroblasts, endothelial cells, cancer cell origin (CCOs). Due high heterogeneity, CCOs excluded demonstration. cells also annotated four spatial regions, including tumor, inner margin, outer margin, stroma. tumor stroma regions defined based density cancer cells. inner outer margins delineated regions extending 250 μm inside outside tumor boundaries, respectively. addition, assessed distance single cell tumor/stroma interface computing shortest Euclidean distance tumor regions (stromal regions) cells localized stromal region (tumor regions). positive distance used cells localized tumor region, negative distance used cells localized stroma region. First load required packages vignette","code":"suppressPackageStartupMessages(library(dplyr)) suppressPackageStartupMessages(library(ggplot2)) suppressPackageStartupMessages(library(parallel)) suppressPackageStartupMessages(library(Seurat)) suppressPackageStartupMessages(library(data.table)) suppressPackageStartupMessages(library(googledrive)) suppressPackageStartupMessages(library(NMF)) suppressPackageStartupMessages(library(ComplexHeatmap)) library(SpatialEcoTyper)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"loading-data","dir":"Articles","previous_headings":"","what":"Loading data","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"Spatial EcoTyper analysis requires two input data sample: gene expression matrix: rows represent gene names columns represent cell IDs meta data: data frame least three columns, including “X” (X-coordinate), “Y” (Y-coordinate), “CellType” (cell type annotation). row names meta data match column names (cell IDs) expression matrix. First, download demo data Google Drive , load text files R. can use read.table small files data.table::fread larger files. Mtx files can loaded R using ReadMtx function Seurat package.","code":"drive_deauth() # Disable Google sign-in requirement drive_download(as_id(\"1CoQmU3u8MoVC8RbLUvTDQmOuJJ703HHB\"), \"HumanMelanomaPatient1_subset_counts.tsv.gz\", overwrite = TRUE) drive_download(as_id(\"1CgUOQKrWY_TG61o5aw7J9LZzE20D6NuI\"), \"HumanMelanomaPatient1_subset_scmeta.tsv\", overwrite = TRUE) drive_download(as_id(\"1ChwONUjr_yoURodnkDBj68ZUbjdHtmP6\"), \"HumanColonCancerPatient2_subset_counts.tsv.gz\", overwrite = TRUE) drive_download(as_id(\"1CipRjjD7cqzqKO0Yf4LUdsEw1XDzP6JS\"), \"HumanColonCancerPatient2_subset_scmeta.tsv\", overwrite = TRUE) # Load single-cell metadata # Row names should be cell ids. Required columns: X, Y, CellType;  # Recommend a 'Region' column if pathologist region annotations are available scmeta1 <- read.table(\"HumanMelanomaPatient1_subset_scmeta.tsv\",                       sep = \"\\t\", header = TRUE, row.names = 1) scmeta2 <- read.table(\"HumanColonCancerPatient2_subset_scmeta.tsv\",                       sep = \"\\t\", header = TRUE, row.names = 1) head(scmeta1[, c(\"X\", \"Y\", \"CellType\", \"Region\")]) ##                                         X         Y   CellType Region ## HumanMelanomaPatient1__cell_3655 1894.706 -6367.766 Fibroblast Stroma ## HumanMelanomaPatient1__cell_3657 1942.480 -6369.602 Fibroblast Stroma ## HumanMelanomaPatient1__cell_3658 1963.007 -6374.026 Fibroblast Stroma ## HumanMelanomaPatient1__cell_3660 1981.600 -6372.266 Fibroblast Stroma ## HumanMelanomaPatient1__cell_3661 1742.939 -6374.851 Fibroblast Stroma ## HumanMelanomaPatient1__cell_3663 1921.683 -6383.309 Fibroblast Stroma head(scmeta2[, c(\"X\", \"Y\", \"CellType\", \"Region\")]) ##                                            X         Y   CellType       Region ## HumanColonCancerPatient2__cell_1085 5057.912 -1721.871 Macrophage Inner margin ## HumanColonCancerPatient2__cell_1205 5035.339 -1783.352 Macrophage Inner margin ## HumanColonCancerPatient2__cell_1312 5012.093 -1908.390 Macrophage Inner margin ## HumanColonCancerPatient2__cell_1625 5073.743 -1861.740 Macrophage Inner margin ## HumanColonCancerPatient2__cell_1629 5030.235 -1867.441 Macrophage Inner margin ## HumanColonCancerPatient2__cell_1639 5020.448 -1882.751 Macrophage Inner margin # Load single-cell gene expression data. Rows represent gene names and columns represent cell IDs scdata1 <- fread(\"HumanMelanomaPatient1_subset_counts.tsv.gz\",                 sep = \"\\t\",header = TRUE, data.table = FALSE) rownames(scdata1) <- scdata1[, 1]  # Setting the first column as row names scdata1 <- as.matrix(scdata1[, -1]) # Dropping first column  scdata2 <- fread(\"HumanColonCancerPatient2_subset_counts.tsv.gz\",                 sep = \"\\t\",header = TRUE, data.table = FALSE) rownames(scdata2) <- scdata2[, 1] # Setting the first column as row names scdata2 <- as.matrix(scdata2[, -1]) # Dropping first column head(scdata1[,1:5]) ##          HumanMelanomaPatient1__cell_3655 HumanMelanomaPatient1__cell_3657 ## PDK4                                    0                                1 ## TNFRSF17                                0                                0 ## ICAM3                                   0                                0 ## FAP                                     1                                0 ## GZMB                                    0                                0 ## TSC2                                    0                                0 ##          HumanMelanomaPatient1__cell_3658 HumanMelanomaPatient1__cell_3660 ## PDK4                                    1                                0 ## TNFRSF17                                0                                0 ## ICAM3                                   0                                0 ## FAP                                     0                                0 ## GZMB                                    0                                0 ## TSC2                                    0                                0 ##          HumanMelanomaPatient1__cell_3661 ## PDK4                                    0 ## TNFRSF17                                0 ## ICAM3                                   0 ## FAP                                     0 ## GZMB                                    0 ## TSC2                                    0 head(scdata2[,1:5]) ##         HumanColonCancerPatient2__cell_1085 HumanColonCancerPatient2__cell_1205 ## PDK4                                      0                                   0 ## CCL26                                     0                                   0 ## CX3CL1                                    0                                   0 ## PGLYRP1                                   0                                   0 ## CD4                                       0                                   0 ## SNAI2                                     0                                   0 ##         HumanColonCancerPatient2__cell_1312 HumanColonCancerPatient2__cell_1625 ## PDK4                                      1                                   0 ## CCL26                                     0                                   0 ## CX3CL1                                    0                                   0 ## PGLYRP1                                   0                                   0 ## CD4                                       0                                   0 ## SNAI2                                     0                                   0 ##         HumanColonCancerPatient2__cell_1629 ## PDK4                                      0 ## CCL26                                     0 ## CX3CL1                                    0 ## PGLYRP1                                   0 ## CD4                                       0 ## SNAI2                                     0 # Make sure row names of the meta data match column names of the gene expression matrix scdata1 <- scdata1[, match(rownames(scmeta1), colnames(scdata1))] scdata2 <- scdata2[, match(rownames(scmeta2), colnames(scdata2))] drive_download(as_id(\"13M3xhRxp0xK9gf5F4DE9idSBFqVQIXDT\"), \"HumanMelanomaPatient1_subset_counts.mtx.gz\", overwrite = TRUE) drive_download(as_id(\"136feRaFjMtNvduLTm5xqa3WhyyoG4Xzo\"), \"HumanMelanomaPatient1_subset_cells.tsv.gz\", overwrite = TRUE) drive_download(as_id(\"13QprWzJhzzUy_w3XSrjlt9pjf2n-G7HV\"), \"HumanMelanomaPatient1_subset_genes.tsv.gz\", overwrite = TRUE)  drive_download(as_id(\"17fH9BAAugYi1FMLrMuTxojtOoklFBB-K\"), \"HumanColonCancerPatient2_subset_counts.mtx.gz\", overwrite = TRUE) drive_download(as_id(\"17a1f1VjxJSje_uyPt6zA97zTps9ko6rk\"), \"HumanColonCancerPatient2_subset_cells.tsv.gz\", overwrite = TRUE) drive_download(as_id(\"17fH0jE5b2YqJ5fpQtYil27k-7YhzArD6\"), \"HumanColonCancerPatient2_subset_genes.tsv.gz\", overwrite = TRUE) scdata1 <- ReadMtx(mtx = \"HumanMelanomaPatient1_subset_counts.mtx.gz\", cells = \"HumanMelanomaPatient1_subset_cells.tsv.gz\", features = \"HumanMelanomaPatient1_subset_genes.tsv.gz\", feature.column = 1, cell.column = 1) scdata2 <- ReadMtx(mtx = \"HumanColonCancerPatient2_subset_counts.mtx.gz\", cells = \"HumanColonCancerPatient2_subset_cells.tsv.gz\", features = \"HumanColonCancerPatient2_subset_genes.tsv.gz\", feature.column = 1, cell.column = 1)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"data-normalization","dir":"Articles","previous_headings":"","what":"Data normalization","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"Gene expression data normalized SpatialEcoTyper analysis. can achieved using either NormalizeData SCTransform. Alternatively, may skip step allow MultiSpatialEcoTyper function handle normalization specifying desired method (e.g., SCT) normalization.method argument. faster computation, recommended install glmGamPoi package SCTransform normalization.","code":"## Install the glmGamPoi package if(!\"glmGamPoi\" %in% installed.packages()){   BiocManager::install(\"glmGamPoi\") }  ## Data normalization tmpobj1 <- CreateSeuratObject(scdata1) %>%       SCTransform(clip.range = c(-10, 10), verbose = FALSE) tmpobj2 <- CreateSeuratObject(scdata2) %>%       SCTransform(clip.range = c(-10, 10), verbose = FALSE)  ## Extract the normalized gene expression data seurat_version = as.integer(gsub(\"\\\\..*\", \"\", as.character(packageVersion(\"SeuratObject\")))) if(seurat_version<5){   normdata1 <- GetAssayData(tmpobj1, \"data\")   normdata2 <- GetAssayData(tmpobj2, \"data\") }else{   normdata1 <- tmpobj1[[\"SCT\"]]$data   normdata2 <- tmpobj2[[\"SCT\"]]$data } normdata1 <- NormalizeData(scdata1) normdata2 <- NormalizeData(scdata2)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"preview-of-the-samples","dir":"Articles","previous_headings":"","what":"Preview of the samples","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"SpatialView function can used visualize spatial distribution single cells within tissues.  SpatialView function can also used visualize spatial landscape regions samples.  can also visualize continuous characteristics, minimum distance single cell tumor/stroma margin, using SpatialView function. , positive distances indicate cells located within tumor region, negative distances denote cells within stroma.","code":"# Visualize the cell type annotations in the tissue p1 <- SpatialView(scmeta1, by = \"CellType\") + labs(title = \"SKCM\") +         scale_color_manual(values = pals::cols25()) + theme(legend.position = \"none\") p2 <- SpatialView(scmeta2, by = \"CellType\") + labs(title = \"CRC\") +         scale_color_manual(values = pals::cols25()) p1 + p2 # Visualize the regions in the tissue p1 <- SpatialView(scmeta1, by = \"Region\") + labs(title = \"SKCM\") +         scale_color_brewer(type = \"qual\", palette = \"Set1\") +          theme(legend.position = \"none\") p2 <- SpatialView(scmeta2, by = \"Region\") + labs(title = \"CRC\") +         scale_color_brewer(type = \"qual\", palette = \"Set1\") p1 + p2 # Visualize the distance to tumor margin p1 <- SpatialView(scmeta1, by = \"Dist2Interface\") + labs(title = \"SKCM\") +          scale_colour_gradient2(low = \"#5e3c99\", high = \"#e66101\", mid = \"#d9d9d9\", midpoint = 0) +         theme(legend.position = \"none\") p2 <- SpatialView(scmeta2, by = \"Dist2Interface\") + labs(title = \"CRC\") +          scale_colour_gradient2(low = \"#5e3c99\", high = \"#e66101\", mid = \"#d9d9d9\", midpoint = 0) + labs(color = \"Distance to\\ntumor margin\") p1 + p2 ## Visualize gene expression in the tissue gg <- scmeta1 gg$Expression <- normdata1[\"STAT1\", ] p1 <- SpatialView(gg, by = \"Expression\") +    scale_color_viridis_c() + labs(color = \"STAT1\") gg <- scmeta2 gg$Expression <- normdata2[\"STAT1\", ] p2 <- SpatialView(gg, by = \"Expression\") +    scale_color_viridis_c() + labs(color = \"STAT1\") p1 + p2"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"spatial-ecotyper-analysis-across-multiple-samples","dir":"Articles","previous_headings":"","what":"Spatial EcoTyper analysis across multiple samples","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"MultiSpatialEcoTyper function enables integration single-cell spatial transcriptomics data across multiple samples, facilitating identification SEs shared across samples cancer types. analysis performed three stages: Independent Spatial EcoTyper Analysis: Spatial EcoTyper run sample independently identify spatial clusters construct cell-type-specific gene expression profiles spatial clusters. Integration via Similarity Network Fusion: Spatial clusters different samples integrated learn unified embedding using Similarity Network Fusion (Wang et al., 2014). NMF Clustering: Non-negative Matrix Factorization (NMF) applied unified embedding identify conserved SEs across samples. data_list named list expression matrices matrix represents gene expression data sample. columns matrix correspond cells, rows correspond genes. list names match sample names; otherwise, samples named ‘Sample1’, ‘Sample2’, etc. metadata_list named list metadata data frames, data frame contains metadata corresponding cells expression matrices. metadata data frame include least three columns (X, Y, CellType), row names match cell IDs (column names) expression matrix. outdir Directory results saved. Defaults current directory subdirectory named “SpatialEcoTyper_results_” followed current date. normalization.method Method normalizing expression data. Options include “None” (default), “SCT”, methods compatible Seurat’s NormalizeData function. nmf_ranks Integer vector specifying number clusters (10 default). vector provided, function tests ranks selects optimal rank NMF, though may increase computation time. radius Numeric specifying radius (units spatial coordinates) defining spatial neighborhoods around cell. Default 50. minibatch Integer specifying number columns (default: 5000) process minibatch SNF analysis. option splits matrix smaller chunks, thus reducing memory usage. ncores Integer specifying number cores parallel processing (default: 1). can type ?MultiSpatialEcoTyper visualize full manual. Important note: examples , use 10 clusters 5 runs per rank demonstration purposes. select optimal number clusters obtain robust results, can use nmf_ranks argument vector integers test multiple ranks NMF analysis. can also use nmfClustering function rank selection, outlined next section (NMF clustering SpatialEcoTyper).","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"preparing-data","dir":"Articles","previous_headings":"Spatial EcoTyper analysis across multiple samples","what":"Preparing data","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"","code":"data_list <- list(SKCM = normdata1, CRC = normdata2) metadata_list <- list(SKCM = scmeta1, CRC = scmeta2)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"pathologist-region-annotation-unavailable","dir":"Articles","previous_headings":"Spatial EcoTyper analysis across multiple samples","what":"Pathologist region annotation unavailable","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"","code":"MultiSpatialEcoTyper(data_list, metadata_list,                       normalization.method = \"None\", # Normalization method                      nmf_ranks = 10,  # Number of clusters                      nrun.per.rank = 5,  # Recommend 30 or higher for robust results                      ncores = 2) # This demo takes ~3 minutes on a macOS with an Apple M1 Pro chip and 16 GB memory."},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"pathologist-region-annotation-available","dir":"Articles","previous_headings":"Spatial EcoTyper analysis across multiple samples","what":"Pathologist region annotation available","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"region annotations available, recommend include region annotations metadata specify Region MultiSpatialEcoTyper function, improve integration accuracy.","code":"## Annotation of tumor and stroma regions will be considered for the analysis. metadata_list$SKCM$Region2 = metadata_list$SKCM$Region metadata_list$CRC$Region2 = metadata_list$CRC$Region metadata_list$SKCM$Region2 = ifelse(metadata_list$SKCM$Dist2Interface<0, \"Stroma\", \"Tumor\") metadata_list$CRC$Region2 = ifelse(metadata_list$CRC$Dist2Interface<0, \"Stroma\", \"Tumor\") MultiSpatialEcoTyper(data_list, metadata_list,                       normalization.method = \"None\", # Normalization method                      min.cts.per.region = 2, # At least two cell types in each microregion                      nmf_ranks = 10,  # Number of clusters                      nrun.per.rank = 5,  # Recommend 30 or higher for robust results                      Region = \"Region2\", # Use pathologist annotations if available                      ncores = 2) ## This demo takes ~3 minutes to complete on macOS with an Apple M1 Pro chip and 16 GB memory."},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"pathologist-region-annotation-available-2","dir":"Articles","previous_headings":"Spatial EcoTyper analysis across multiple samples","what":"Pathologist region annotation available (2)","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"can specify nmf_ranks argument vector integers test multiple ranks, enabling selection optimal number clusters. ’ve already run SpatialEcoTyper sample, can integrate results directly using IntegrateSpatialEcoTyper. real-world single-cell ST datasets 100,000 cells, analysis can time- memory-intensive. speed process, can increase number cores used (ncores), also increase memory consumption. limited computational memory, several strategies reduce usage. One approach decrease minibatch size reduce number cores (ncores) allocated. However, larger datasets, minimum memory requirement may remain high. Another option increase binsize, reduces number spatial microregions. can significantly decrease memory usage downsampling ST data, potentially excluding many cells analysis though. ’re interested studying multicellular communities associated specific cell types, can use filter.region..celltypes argument focus microregions containing least one cell specified cell types. example available Discovery Spatial Ecotypes Single Sample. ’re interested regions composed multiple cell types, can use min.cts.per.region argument specify minimum number distinct cell types required microregion included analysis.","code":"## Annotation of tumor and stroma regions will be considered for the analysis. metadata_list$SKCM$Region2 = metadata_list$SKCM$Region metadata_list$CRC$Region2 = metadata_list$CRC$Region metadata_list$SKCM$Region2 = ifelse(metadata_list$SKCM$Dist2Interface<0, \"Stroma\", \"Tumor\") metadata_list$CRC$Region2 = ifelse(metadata_list$CRC$Dist2Interface<0, \"Stroma\", \"Tumor\") MultiSpatialEcoTyper(data_list, metadata_list,                       normalization.method = \"None\", # Normalization method                      nmf_ranks = seq(4,15,2),  # Number of clusters                      nrun.per.rank = 30,  # 30 runs per rank for robust results                      Region = \"Region2\", # Use pathologist annotations                      ncores = 2) ## This demo takes ~16 minutes to complete on macOS with an Apple M1 Pro chip and 16 GB memory. drive_download(as_id(\"126OSOk8sAaxhJID1D3-75bI9S-to9Lkg\"), \"CRC_SpatialEcoTyper_results.rds\", overwrite = TRUE) drive_download(as_id(\"11y0lcpawQAZAvDCnt3tBQsF90Wet0lKe\"), \"SKCM_SpatialEcoTyper_results.rds\", overwrite = TRUE) data_list <- list(SKCM = normdata1, CRC = normdata2) SpatialEcoTyper_list <- list(SKCM = readRDS(\"SKCM_SpatialEcoTyper_results.rds\"),                              CRC = readRDS(\"CRC_SpatialEcoTyper_results.rds\")) IntegrateSpatialEcoTyper(SpatialEcoTyper_list, data_list,                           outdir = \"SpatialEcoTyper_results/\",                          normalization.method = \"None\",                           nmf_ranks = 10, # Number of clusters                          nrun.per.rank = 5,  # recommend 30 or higher for robust results                          Region = \"Region2\", # Use pathologist annotations if available                          ncores = 2) # This demo takes ~3 minutes on a macOS with an Apple M1 Pro chip and 16 GB memory."},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"output-results","dir":"Articles","previous_headings":"","what":"Output results","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"results saved specified directory (outdir) subdirectory named SpatialEcoTyper_results_ followed current date. output files include: (SampleName)_SpatialEcoTyper_results.rds SpatialEcoTyper result sample. MultiSE_integrated_final.rds matrix representing fused similarity matrix spatial clusters across samples. MultiSE_integrated_final_hmap.pdf heatmap visualizing fused similarity matrix spatial clusters, grouped samples SEs. MultiSE_metadata_final.rds Single-cell metadata ‘SE’ column annotating discovered SEs, saved RDS file. MultiSE_metadata_final.tsv MultiSE_metadata_final.rds, saved TSV format. SpatialView_SEs_by_Sample.pdf figure showing spatial landscape SEs across samples. BarView_SEs_Sample_Frac.pdf bar plot showing fraction cells sample represented within SE. BarView_SEs_Region_Frac_Avg.pdf bar plot showing average fraction regions represented within SE. BarView_SEs_CellType_Frac_Avg.pdf bar plot showing average cell type composition within SE. MultiSE_NMF_results.rds NMF result derived nmfClustering function. single rank provided, contains NMFfitX1 object . multiple ranks provided, list containing optimal number communities (bestK), list NMFfitX1 objects (NMFfits), ggplot object (p) displaying cophenetic coefficient different cluster numbers. MultiSE_NMF_Cophenetic_Dynamics.pdf figure showing cophenetic coefficients different numbers clusters, available multiple ranks provided. results demo data can downloaded MultiSpatialEcoTyper_results.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"nmf-clustering","dir":"Articles","previous_headings":"","what":"NMF clustering","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"Spatial EcoTyper uses NMF group spatial clusters multiple samples conserved SEs. determine optimal number clusters, rank, computed cophenetic coefficient, quantifies classification stability given rank (.e., number clusters) ranges 0 1, 1 indicating maximally stability. Typically, rank cophenetic coefficient begins decrease chosen. However, method can challenging cophenetic coefficient exhibits multi-modal shape across different ranks. cases, Spatial EcoTyper analysis, recommend selecting number SEs coefficient drops 0.95 default.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"selecting-the-optimal-rank","dir":"Articles","previous_headings":"NMF clustering","what":"Selecting the optimal rank","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"determine optimal rank, can use nmfClustering function, tests multiple ranks computes cophenetic coefficient . analysis requires fused similarity network matrix (MultiSE_integrated_final.rds) generated previous step. Load files R: Next, test multiple ranks find optimal number SEs. running time step depends data size, number ranks test, number runs per rank, number cores parallel analysis. demonstration, test six different ranks ranging 4 15 5 runs per rank. better understand cophenetic coefficient changes different ranks, can visualize results.  optimal rank determined, can use generate final SE annotations. can add newly defined SEs meta data","code":"## Fused similarity matrix of spatial clusters across all samples outdir = paste0(\"SpatialEcoTyper_results_\", Sys.Date()) integrated = readRDS(file.path(outdir, \"MultiSE_integrated_final.rds\")) dim(integrated) ## [1] 376 376 ## Single-cell metadata with an 'SE' column annotating the discovered SEs finalmeta = readRDS(file.path(outdir, \"MultiSE_metadata_final.rds\")) head(finalmeta[, c(\"Sample\", \"X\", \"Y\", \"CellType\", \"Region\", \"InitSE\", \"SE\")]) ##                                  Sample        X         Y   CellType Region ## HumanMelanomaPatient1__cell_3655   SKCM 1894.706 -6367.766 Fibroblast Stroma ## HumanMelanomaPatient1__cell_3657   SKCM 1942.480 -6369.602 Fibroblast Stroma ## HumanMelanomaPatient1__cell_3658   SKCM 1963.007 -6374.026 Fibroblast Stroma ## HumanMelanomaPatient1__cell_3660   SKCM 1981.600 -6372.266 Fibroblast Stroma ## HumanMelanomaPatient1__cell_3661   SKCM 1742.939 -6374.851 Fibroblast Stroma ## HumanMelanomaPatient1__cell_3663   SKCM 1921.683 -6383.309 Fibroblast Stroma ##                                          InitSE  SE ## HumanMelanomaPatient1__cell_3655 SKCM..InitSE77 SE3 ## HumanMelanomaPatient1__cell_3657 SKCM..InitSE63 SE4 ## HumanMelanomaPatient1__cell_3658 SKCM..InitSE63 SE4 ## HumanMelanomaPatient1__cell_3660 SKCM..InitSE63 SE4 ## HumanMelanomaPatient1__cell_3661 SKCM..InitSE60 SE3 ## HumanMelanomaPatient1__cell_3663 SKCM..InitSE77 SE3 nmf_res <- nmfClustering(integrated, ranks = seq(4,15,2),                          nrun.per.rank = 5, # Recommend 30 or higher                          min.coph = 0.99, # minimum cophenetic coefficient threshold                          ncores = 4,                          seed = 2024) ## This process takes ~3 minutes on a macOS with an Apple M1 Pro chip and 16 GB of memory paste0(\"The selected rank is \", nmf_res$bestK) ## [1] \"The selected rank is 4\" plot(nmf_res$p) ses <- predict(nmf_res$NMFfits[[paste0(\"K.\", nmf_res$bestK)]]) head(ses) ##   SKCM..InitSE1  SKCM..InitSE74 SKCM..InitSE110  SKCM..InitSE16 SKCM..InitSE111  ##               1               2               2               2               2  ##  SKCM..InitSE24  ##               2  ## Levels: 1 2 3 4 finalmeta$SE = paste0(\"SE\", ses[finalmeta$InitSE]) head(finalmeta) ##                                                               CID        X ## HumanMelanomaPatient1__cell_3655 HumanMelanomaPatient1__cell_3655 1894.706 ## HumanMelanomaPatient1__cell_3657 HumanMelanomaPatient1__cell_3657 1942.480 ## HumanMelanomaPatient1__cell_3658 HumanMelanomaPatient1__cell_3658 1963.007 ## HumanMelanomaPatient1__cell_3660 HumanMelanomaPatient1__cell_3660 1981.600 ## HumanMelanomaPatient1__cell_3661 HumanMelanomaPatient1__cell_3661 1742.939 ## HumanMelanomaPatient1__cell_3663 HumanMelanomaPatient1__cell_3663 1921.683 ##                                          Y   CellType CellTypeName Region ## HumanMelanomaPatient1__cell_3655 -6367.766 Fibroblast  Fibroblasts Stroma ## HumanMelanomaPatient1__cell_3657 -6369.602 Fibroblast  Fibroblasts Stroma ## HumanMelanomaPatient1__cell_3658 -6374.026 Fibroblast  Fibroblasts Stroma ## HumanMelanomaPatient1__cell_3660 -6372.266 Fibroblast  Fibroblasts Stroma ## HumanMelanomaPatient1__cell_3661 -6374.851 Fibroblast  Fibroblasts Stroma ## HumanMelanomaPatient1__cell_3663 -6383.309 Fibroblast  Fibroblasts Stroma ##                                  Dist2Interface Region2         InitSE Sample ## HumanMelanomaPatient1__cell_3655      -883.1752  Stroma SKCM..InitSE77   SKCM ## HumanMelanomaPatient1__cell_3657      -894.8463  Stroma SKCM..InitSE63   SKCM ## HumanMelanomaPatient1__cell_3658      -904.1115  Stroma SKCM..InitSE63   SKCM ## HumanMelanomaPatient1__cell_3660      -907.8909  Stroma SKCM..InitSE63   SKCM ## HumanMelanomaPatient1__cell_3661      -874.2712  Stroma SKCM..InitSE60   SKCM ## HumanMelanomaPatient1__cell_3663      -903.6559  Stroma SKCM..InitSE77   SKCM ##                                   SE ## HumanMelanomaPatient1__cell_3655 SE1 ## HumanMelanomaPatient1__cell_3657 SE1 ## HumanMelanomaPatient1__cell_3658 SE1 ## HumanMelanomaPatient1__cell_3660 SE1 ## HumanMelanomaPatient1__cell_3661 SE1 ## HumanMelanomaPatient1__cell_3663 SE1"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"using-a-different-rank","dir":"Articles","previous_headings":"NMF clustering","what":"Using a different rank","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"simply want experiment different rank, can use nmfClustering function. single rank specified, directly returns NMFfit object predicting SE grouping, shown : can add newly defined SEs meta data","code":"nmf_res <- nmfClustering(integrated, ranks = 10, nrun.per.rank = 30,                           seed = 1, ncores = 1) ses <- predict(nmf_res) ## This process takes ~6 minutes on a macOS with an Apple M1 Pro chip and 16 GB of memory finalmeta$SE = paste0(\"SE\", ses[finalmeta$InitSE]) head(finalmeta) ##                                                               CID        X ## HumanMelanomaPatient1__cell_3655 HumanMelanomaPatient1__cell_3655 1894.706 ## HumanMelanomaPatient1__cell_3657 HumanMelanomaPatient1__cell_3657 1942.480 ## HumanMelanomaPatient1__cell_3658 HumanMelanomaPatient1__cell_3658 1963.007 ## HumanMelanomaPatient1__cell_3660 HumanMelanomaPatient1__cell_3660 1981.600 ## HumanMelanomaPatient1__cell_3661 HumanMelanomaPatient1__cell_3661 1742.939 ## HumanMelanomaPatient1__cell_3663 HumanMelanomaPatient1__cell_3663 1921.683 ##                                          Y   CellType CellTypeName Region ## HumanMelanomaPatient1__cell_3655 -6367.766 Fibroblast  Fibroblasts Stroma ## HumanMelanomaPatient1__cell_3657 -6369.602 Fibroblast  Fibroblasts Stroma ## HumanMelanomaPatient1__cell_3658 -6374.026 Fibroblast  Fibroblasts Stroma ## HumanMelanomaPatient1__cell_3660 -6372.266 Fibroblast  Fibroblasts Stroma ## HumanMelanomaPatient1__cell_3661 -6374.851 Fibroblast  Fibroblasts Stroma ## HumanMelanomaPatient1__cell_3663 -6383.309 Fibroblast  Fibroblasts Stroma ##                                  Dist2Interface Region2         InitSE Sample ## HumanMelanomaPatient1__cell_3655      -883.1752  Stroma SKCM..InitSE77   SKCM ## HumanMelanomaPatient1__cell_3657      -894.8463  Stroma SKCM..InitSE63   SKCM ## HumanMelanomaPatient1__cell_3658      -904.1115  Stroma SKCM..InitSE63   SKCM ## HumanMelanomaPatient1__cell_3660      -907.8909  Stroma SKCM..InitSE63   SKCM ## HumanMelanomaPatient1__cell_3661      -874.2712  Stroma SKCM..InitSE60   SKCM ## HumanMelanomaPatient1__cell_3663      -903.6559  Stroma SKCM..InitSE77   SKCM ##                                    SE ## HumanMelanomaPatient1__cell_3655  SE4 ## HumanMelanomaPatient1__cell_3657 SE10 ## HumanMelanomaPatient1__cell_3658 SE10 ## HumanMelanomaPatient1__cell_3660 SE10 ## HumanMelanomaPatient1__cell_3661  SE4 ## HumanMelanomaPatient1__cell_3663  SE4"},{"path":[]},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"visualizing-the-integrated-similarity-matrix","dir":"Articles","previous_headings":"Visualizing SEs","what":"Visualizing the integrated similarity matrix","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"reordering spatial clusters based newly identified SEs, can re-draw heatmap show fused similarity matrix spatial clusters across samples.","code":"ords = names(ses)[order(ses)] integrated = integrated[ords, ords] # reorder the cells ann <- data.frame(Sample = gsub(\"\\\\.\\\\..*\", \"\", rownames(integrated)),                   SE = paste0(\"SE\", ses[ords]),                   row.names = rownames(integrated)) # cell groups SE_cols <- getColors(length(unique(ann$SE)), palette = 1) # colors for SEs names(SE_cols) <- unique(ann$SE) sample_cols <- getColors(length(unique(ann$Sample)), palette = 2) # colors for samples names(sample_cols) <- unique(ann$Sample)  ## draw heatmap HeatmapView(integrated, show_row_names = FALSE, show_column_names = FALSE,             top_ann = ann, top_ann_col = list(Sample = sample_cols, SE = SE_cols)) drawRectangleAnnotation(ann$SE, ann$SE)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"visualizing-ses-in-the-tissue","dir":"Articles","previous_headings":"Visualizing SEs","what":"Visualizing SEs in the tissue","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"examine spatial distribution identified SEs, can use SpatialView function visualize SEs tissues.","code":"SpatialView(finalmeta, by = \"SE\")  + facet_wrap(~Sample, scales = \"free\")"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"association-between-ses-and-pre-annotated-regions","dir":"Articles","previous_headings":"Visualizing SEs","what":"Association between SEs and pre-annotated regions","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"examine enrichment SEs pre-annotated regions, can visualize cell fractions region, SE.","code":"gg <- finalmeta %>% filter(!is.na(SE)) %>% count(SE, Region, Sample) %>%      group_by(Sample, SE) %>% mutate(Frac = n / sum(n)) %>% ## cell type fractions within each sample     group_by(SE, Region) %>% summarise(Frac = mean(Frac)) ## average cell type fractions across all samples ggplot(gg, aes(SE, Frac, fill = Region)) +    geom_bar(stat = \"identity\", position = \"fill\") +    scale_fill_brewer(type = \"qual\", palette = \"Set1\") +   theme_bw(base_size = 14) + coord_flip() +    labs(y = \"Fraction\") gg <- finalmeta %>% filter(!is.na(SE)) %>% count(SE, Region, Sample)  ggplot(gg, aes(SE, n, fill = Region)) +    geom_bar(stat = \"identity\", position = \"fill\") +    scale_fill_brewer(type = \"qual\", palette = \"Set1\") +   facet_wrap(~Sample) +   theme_bw(base_size = 14) + coord_flip() +    labs(y = \"Fraction of regions\")"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"distance-of-ses-to-tumorstroma-interface","dir":"Articles","previous_headings":"Visualizing SEs","what":"Distance of SEs to tumor/stroma interface","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"box plot visualizes distribution distances SEs tumor/stroma interface. Positive distances indicate cells located within tumor region, negative distances denote cells within stroma. SEs ordered median distance, highlighting spatial localization relative tumor/stroma interface.","code":"gg <- finalmeta %>% filter(!is.na(SE)) %>% group_by(Sample, SE) %>%    summarise(Dist2Interface = mean(Dist2Interface)) %>% arrange(Dist2Interface) gg$SE = factor(gg$SE, levels = unique(gg$SE)) ggplot(gg, aes(SE, Dist2Interface)) + geom_boxplot() +    geom_point(aes(color = Sample)) + theme_bw() +    labs(y = \"Distance to tumor/stroma interface (μm)\")"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"cell-type-composition-of-ses","dir":"Articles","previous_headings":"Visualizing SEs","what":"Cell type composition of SEs","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"can visualize cell type composition SEs bar plot. cell type fractions can averaged across two samples. Average cell type composition SEs across samples","code":"gg <- finalmeta %>% filter(!is.na(SE)) %>% count(SE, CellType, Sample) %>%      group_by(Sample, SE) %>% mutate(Frac = n / sum(n)) %>% ## cell type fractions within each sample     group_by(SE, CellType) %>% summarise(Frac = mean(Frac)) ## average cell type fractions across all samples  ggplot(gg, aes(SE, Frac, fill = CellType)) +    geom_bar(stat = \"identity\", position = \"fill\") +   scale_fill_manual(values = pals::cols25()) +   theme_bw(base_size = 14) + coord_flip() +    labs(y = \"Cell type abundance\") gg <- finalmeta %>% filter(!is.na(SE)) %>% count(SE, CellType, Sample)  ggplot(gg, aes(SE, n, fill = CellType)) +    geom_bar(stat = \"identity\", position = \"fill\") +   scale_fill_manual(values = pals::cols25()) +   facet_wrap(~Sample) +   theme_bw(base_size = 14) + coord_flip() +    labs(y = \"Cell type abundance\")"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"identification-of-cell-type-specific-se-markers","dir":"Articles","previous_headings":"","what":"Identification of cell-type-specific SE markers","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"can identify cell-type-specific SE markers differential expression analysis using presto package. example identify fibroblast-specific markers SE.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"de-analysis-within-each-sample","dir":"Articles","previous_headings":"Identification of cell-type-specific SE markers","what":"DE analysis within each sample","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"","code":"require(\"presto\") ## DE analysis within the first sample tmpmeta1 = finalmeta %>% filter(CellType==\"Fibroblast\" & Sample==\"SKCM\" & (!is.na(SE))) tmpdata1 = normdata1[, tmpmeta1$CID] degs1 = wilcoxauc(tmpdata1, tmpmeta1$SE) ## DE analysis within the second sample tmpmeta2 = finalmeta %>% filter(CellType==\"Fibroblast\" & Sample==\"CRC\" & (!is.na(SE))) tmpdata2 = normdata2[, tmpmeta2$CID] degs2 = wilcoxauc(tmpdata2, tmpmeta2$SE) # DE analysis  head(degs1) ##    feature group     avgExpr        logFC statistic       auc         pval ## 1     PDK4  SE10 0.117555097  0.047787757   4701164 0.5269201 2.300787e-09 ## 2 TNFRSF17  SE10 0.000000000  0.000000000   4460984 0.5000000 1.000000e+00 ## 3    ICAM3  SE10 0.000000000  0.000000000   4460984 0.5000000 1.000000e+00 ## 4      FAP  SE10 0.102200894 -0.037071606   4241882 0.4754425 1.963176e-05 ## 5     GZMB  SE10 0.007441764 -0.008093071   4423277 0.4957737 3.439501e-02 ## 6     TSC2  SE10 0.006910210 -0.002427312   4446112 0.4983331 3.257778e-01 ##           padj     pct_in   pct_out ## 1 1.030353e-08 14.2638037  9.003215 ## 2 1.000000e+00  0.0000000  0.000000 ## 3 1.000000e+00  0.0000000  0.000000 ## 4 6.684535e-05 13.3435583 18.269512 ## 5 8.335732e-02  1.0736196  1.914645 ## 6 6.484080e-01  0.9969325  1.330020 head(degs2) ##    feature group    avgExpr       logFC statistic       auc         pval ## 1     PDK4   SE1 0.07290325 -0.08483371  15082423 0.4580113 3.871812e-25 ## 2   CX3CL1   SE1 0.03282075 -0.01465999  16182732 0.4914246 7.090800e-04 ## 3      CD4   SE1 0.00000000  0.00000000  16465120 0.5000000 1.000000e+00 ## 4    SNAI2   SE1 0.35501044  0.11399360  18215060 0.5531408 6.627100e-26 ## 5 TNFRSF17   SE1 0.00000000  0.00000000  16465120 0.5000000 1.000000e+00 ## 6    ICAM3   SE1 0.00000000  0.00000000  16465120 0.5000000 1.000000e+00 ##           padj    pct_in   pct_out ## 1 2.380875e-24  8.921162 17.125293 ## 2 1.848993e-03  4.107884  5.818208 ## 3 1.000000e+00  0.000000  0.000000 ## 4 4.333913e-25 36.431535 26.939403 ## 5 1.000000e+00  0.000000  0.000000 ## 6 1.000000e+00  0.000000  0.000000"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"identifying-conserved-markers-across-samples","dir":"Articles","previous_headings":"Identification of cell-type-specific SE markers","what":"Identifying conserved markers across samples","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"identify markers conserved across different samples, conduct meta-analysis averaging log2 fold changes (log2FC) DE analyses. identify markers specific SE-associated cell state, calculate difference maximum log2FC gene second-highest log2FC:","code":"library(tidyr) degs <- merge(degs1[, c(1,2,4)], degs2[, c(1,2,4)], by = c(\"feature\", \"group\")) degs$AvgLogFC = (degs$logFC.x + degs$logFC.y) / 2 lfcs = degs %>% pivot_wider(id_cols = feature, names_from = group,                              values_from = AvgLogFC) %>% as.data.frame rownames(lfcs) <- lfcs$feature lfcs <- lfcs[, -1] head(lfcs) ##                SE10         SE3         SE4         SE6         SE7         SE8 ## ACKR3    0.04539229 -0.11089193  0.22761738 -0.13915649 -0.16230522  0.05704506 ## ACTA2    0.64868983  0.19121333 -0.28277467 -0.15495698 -0.13060735  0.26294794 ## ADAMTS4 -0.07880286 -0.03558349 -0.10298639  0.15231638  0.14598004 -0.10437673 ## AKT1    -0.11112575 -0.00885807 -0.19659536  0.11531490  0.32156308 -0.09316424 ## AKT2     0.01227246 -0.01219427  0.01067868 -0.01456746  0.01794543 -0.02832473 ## AKT3     0.05820973 -0.05104454 -0.02226315 -0.01922768  0.02741800 -0.03496944 ##                   SE9 ## ACKR3   -2.297758e-02 ## ACTA2   -1.850714e-01 ## ADAMTS4 -3.370712e-03 ## AKT1    -3.274771e-02 ## AKT2    -2.510557e-05 ## AKT3    -2.496374e-02 secondmax = apply(lfcs, 1, function(x){ -sort(-x)[2] }) delta = lfcs - secondmax ## Markers are considered specific if they have a positive delta and a log2FC greater than 0.05: idx = delta>0 & lfcs>0.05 markers = lapply(colnames(lfcs), function(se){   gs = rownames(idx)[idx[, se]]   gs = gs[order(-lfcs[gs, se])]   gs }) names(markers) = colnames(lfcs) markers = markers[lengths(markers)>0] ## Select the top five markers top5 = lapply(markers, function(x){ x[1:min(5, length(x))] }) top5 ## $SE10 ## [1] \"ACTA2\"  \"COL4A1\" \"MYH11\"  \"TGFB3\"  \"TNC\"    ##  ## $SE3 ## [1] \"FN1\"    \"CSF1\"   \"COL5A1\" ##  ## $SE4 ## [1] \"FOS\"     \"PLA2G2A\" \"DUSP1\"   \"EGR1\"    \"FBLN1\"   ##  ## $SE6 ## [1] \"HLA-DRA\" \"BST2\"    \"CXCL9\"   \"STAT1\"   \"SOD2\"    ##  ## $SE7 ## [1] \"PKM\"    \"MMP11\"  \"CTNNB1\" \"TGFBI\"  \"YAP1\"   ##  ## $SE8 ## [1] \"SFRP2\"   \"COL1A1\"  \"SMOC2\"   \"COL11A1\" \"MFAP5\"   ##  ## $SE9 ## [1] \"XBP1\"  \"CXCR4\" \"CCL2\"  \"PTPRC\" \"STAT3\""},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"visualizing-top-se-cell-state-markers","dir":"Articles","previous_headings":"Identification of cell-type-specific SE markers","what":"Visualizing top SE cell state markers","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"","code":"gg = t(scale(t(lfcs[unlist(top5), ]), center = FALSE)) HeatmapView(gg, breaks = c(0, 1, 1.5))"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"session-info","dir":"Articles","previous_headings":"","what":"Session info","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"session info allows users replicate exact environment identify potential discrepancies package versions configurations might causing problems.","code":"sessionInfo() ## R version 4.4.1 (2024-06-14) ## Platform: aarch64-apple-darwin20 ## Running under: macOS 15.1 ##  ## Matrix products: default ## BLAS:   /Library/Frameworks/R.framework/Versions/4.4-arm64/Resources/lib/libRblas.0.dylib  ## LAPACK: /Library/Frameworks/R.framework/Versions/4.4-arm64/Resources/lib/libRlapack.dylib;  LAPACK version 3.12.0 ##  ## locale: ## [1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8 ##  ## time zone: America/Los_Angeles ## tzcode source: internal ##  ## attached base packages: ## [1] grid      parallel  stats     graphics  grDevices utils     datasets  ## [8] methods   base      ##  ## other attached packages: ##  [1] tidyr_1.3.1           presto_1.0.0          Rcpp_1.0.13           ##  [4] pals_1.9              SpatialEcoTyper_1.0.0 RANN_2.6.2            ##  [7] Matrix_1.7-0          ComplexHeatmap_2.20.0 NMF_0.28              ## [10] Biobase_2.64.0        BiocGenerics_0.50.0   cluster_2.1.6         ## [13] rngtools_1.5.2        registry_0.5-1        googledrive_2.1.1     ## [16] data.table_1.16.0     Seurat_5.1.0          SeuratObject_5.0.2    ## [19] sp_2.1-4              ggplot2_3.5.1         dplyr_1.1.4           ##  ## loaded via a namespace (and not attached): ##   [1] RcppAnnoy_0.0.22            splines_4.4.1               ##   [3] later_1.3.2                 tibble_3.2.1                ##   [5] R.oo_1.26.0                 polyclip_1.10-7             ##   [7] fastDummies_1.7.4           lifecycle_1.0.4             ##   [9] doParallel_1.0.17           globals_0.16.3              ##  [11] lattice_0.22-6              MASS_7.3-60.2               ##  [13] magrittr_2.0.3              plotly_4.10.4               ##  [15] sass_0.4.9                  rmarkdown_2.28              ##  [17] jquerylib_0.1.4             yaml_2.3.10                 ##  [19] httpuv_1.6.15               glmGamPoi_1.16.0            ##  [21] sctransform_0.4.1           spam_2.10-0                 ##  [23] spatstat.sparse_3.1-0       reticulate_1.39.0           ##  [25] mapproj_1.2.11              cowplot_1.1.3               ##  [27] pbapply_1.7-2               RColorBrewer_1.1-3          ##  [29] maps_3.4.2                  zlibbioc_1.50.0             ##  [31] abind_1.4-5                 GenomicRanges_1.56.1        ##  [33] Rtsne_0.17                  purrr_1.0.2                 ##  [35] R.utils_2.12.3              GenomeInfoDbData_1.2.12     ##  [37] circlize_0.4.16             IRanges_2.38.1              ##  [39] S4Vectors_0.42.1            ggrepel_0.9.6               ##  [41] irlba_2.3.5.1               listenv_0.9.1               ##  [43] spatstat.utils_3.1-0        goftest_1.2-3               ##  [45] RSpectra_0.16-2             spatstat.random_3.3-1       ##  [47] fitdistrplus_1.2-1          parallelly_1.38.0           ##  [49] DelayedMatrixStats_1.26.0   pkgdown_2.1.0               ##  [51] DelayedArray_0.30.1         leiden_0.4.3.1              ##  [53] codetools_0.2-20            tidyselect_1.2.1            ##  [55] shape_1.4.6.1               farver_2.1.2                ##  [57] UCSC.utils_1.0.0            matrixStats_1.4.1           ##  [59] stats4_4.4.1                spatstat.explore_3.3-2      ##  [61] jsonlite_1.8.8              GetoptLong_1.0.5            ##  [63] progressr_0.14.0            ggridges_0.5.6              ##  [65] survival_3.6-4              iterators_1.0.14            ##  [67] systemfonts_1.1.0           foreach_1.5.2               ##  [69] tools_4.4.1                 ragg_1.3.2                  ##  [71] ica_1.0-3                   glue_1.7.0                  ##  [73] SparseArray_1.4.8           gridExtra_2.3               ##  [75] xfun_0.47                   MatrixGenerics_1.16.0       ##  [77] GenomeInfoDb_1.40.1         withr_3.0.1                 ##  [79] BiocManager_1.30.25         fastmap_1.2.0               ##  [81] fansi_1.0.6                 digest_0.6.37               ##  [83] R6_2.5.1                    mime_0.12                   ##  [85] textshaping_0.4.0           colorspace_2.1-1            ##  [87] scattermore_1.2             tensor_1.5                  ##  [89] dichromat_2.0-0.1           spatstat.data_3.1-2         ##  [91] R.methodsS3_1.8.2           utf8_1.2.4                  ##  [93] generics_0.1.3              S4Arrays_1.4.1              ##  [95] httr_1.4.7                  htmlwidgets_1.6.4           ##  [97] uwot_0.2.2                  pkgconfig_2.0.3             ##  [99] gtable_0.3.5                lmtest_0.9-40               ## [101] XVector_0.44.0              htmltools_0.5.8.1           ## [103] dotCall64_1.1-1             clue_0.3-65                 ## [105] scales_1.3.0                png_0.1-8                   ## [107] spatstat.univar_3.0-1       knitr_1.48                  ## [109] rstudioapi_0.16.0           reshape2_1.4.4              ## [111] rjson_0.2.22                nlme_3.1-164                ## [113] curl_5.2.2                  cachem_1.1.0                ## [115] zoo_1.8-12                  GlobalOptions_0.1.2         ## [117] stringr_1.5.1               KernSmooth_2.23-24          ## [119] miniUI_0.1.1.1              desc_1.4.3                  ## [121] pillar_1.9.0                vctrs_0.6.5                 ## [123] promises_1.3.0              xtable_1.8-4                ## [125] evaluate_0.24.0             magick_2.8.5                ## [127] cli_3.6.3                   compiler_4.4.1              ## [129] rlang_1.1.4                 crayon_1.5.3                ## [131] future.apply_1.11.2         labeling_0.4.3              ## [133] plyr_1.8.9                  fs_1.6.4                    ## [135] stringi_1.8.4               viridisLite_0.4.2           ## [137] deldir_2.0-4                gridBase_0.4-7              ## [139] munsell_0.5.1               lazyeval_0.2.2              ## [141] spatstat.geom_3.3-2         RcppHNSW_0.6.0              ## [143] patchwork_1.2.0             sparseMatrixStats_1.16.0    ## [145] future_1.34.0               shiny_1.9.1                 ## [147] highr_0.11                  SummarizedExperiment_1.34.0 ## [149] ROCR_1.0-11                 gargle_1.5.2                ## [151] igraph_2.0.3                bslib_0.8.0"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_Bulk.html","id":"overview","dir":"Articles","previous_headings":"","what":"Overview","title":"Recovery of Spatial Ecotypes from Bulk Gene Expression Data","text":"tutorial, demonstrate infer spatial ecotype (SE) abundances bulk RNA-seq data. Specifically, infer SE abundances RNA-seq data TCGA melanoma samples. gene expression matrix available SKCM_RNASeqV2.geneExp.tsv, Transcripts Per Million (TPM) matrix obtained PanCanAtlas. First load required packages vignette","code":"suppressPackageStartupMessages(library(googledrive)) suppressPackageStartupMessages(library(Seurat)) suppressPackageStartupMessages(library(data.table)) library(SpatialEcoTyper)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_Bulk.html","id":"loading-bulk-expression-of-tcga-melanoma-samples","dir":"Articles","previous_headings":"","what":"Loading bulk expression of TCGA melanoma samples","title":"Recovery of Spatial Ecotypes from Bulk Gene Expression Data","text":"","code":"drive_deauth() # Disable Google sign-in requirement drive_download(as_id(\"14RwnoxhIkGeLp6GXehmAXLvy8Ii2_COU\"), \"SKCM_RNASeqV2.geneExp.tsv\", overwrite = TRUE) # download data from googledrive bulkdata <- fread(\"SKCM_RNASeqV2.geneExp.tsv\", sep = \"\\t\", data.table = FALSE) rownames(bulkdata) <- bulkdata[, 1] ## Set the first column as row names bulkdata <- bulkdata[, -1] ## Drop the first column head(bulkdata[, 1:5]) ## TPM matrix ##       TCGA.3N.A9WB.06 TCGA.3N.A9WC.06 TCGA.3N.A9WD.06 TCGA.BF.A1PU.01 ## A1BG         381.0660         195.182        360.8790        176.3990 ## A1CF           0.0000           0.000          0.7092          0.0000 ## A2BP1          0.0000           0.000          6.3830          1.2987 ## A2LD1        250.1980         160.755         97.1986        163.2340 ## A2M         2209.5200      169237.000      18257.9000       6716.4500 ## A2ML1          7.2698           0.000          0.0000          7.7922 ##       TCGA.BF.A1PV.01 ## A1BG         216.8470 ## A1CF           0.0000 ## A2BP1          0.0000 ## A2LD1         60.8727 ## A2M         1740.5800 ## A2ML1          0.5977"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_Bulk.html","id":"se-deconvolution","dir":"Articles","previous_headings":"","what":"SE deconvolution","title":"Recovery of Spatial Ecotypes from Bulk Gene Expression Data","text":"DeconvoluteSE function infers SE abundances bulk tissues. Users can choose either use default model, estimates abundance predefined SEs, apply custom model infer abundance newly defined SEs based bulk gene expression data. prediction, gene expression data log2-transformed (max value exceeds 80), followed normalization mean 0 unit variance gene. ensure accurate univariance normalization, minimum sample size 20 recommended. dataset fewer samples, recommend use public datasets reference estimate mean standard deviation default model trained pseudobulk gene expression data predicts abundances nine predefined SEs along nonSE group, primarily includes cancer cells cells associated SEs. predicted SE nonSE abundances sample sum 1, making comparable across samples. Note: 1) SE abundances directly comparable across samples, enabling analysis SE distribution patterns different conditions. 2) Since number cell states varies across SEs, direct abundance comparisons different SEs nonSE group may meaningful. SEs represent distinct spatial multicellular communities, defined unique combination cell states.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_Bulk.html","id":"using-default-model","dir":"Articles","previous_headings":"SE deconvolution","what":"Using default model","title":"Recovery of Spatial Ecotypes from Bulk Gene Expression Data","text":"","code":"sefracs <- DeconvoluteSE(bulkdata, scale = TRUE) head(sefracs) ##                      nonSE        SE1        SE2        SE3        SE4 ## TCGA.3N.A9WB.06 0.19380234 0.05372667 0.16735600 0.12581663 0.07216666 ## TCGA.3N.A9WC.06 0.05293689 0.13901340 0.08427617 0.08372047 0.04243859 ## TCGA.3N.A9WD.06 0.27200075 0.17114795 0.06288761 0.05641549 0.10166721 ## TCGA.BF.A1PU.01 0.16899510 0.13618971 0.06501306 0.09269615 0.17313296 ## TCGA.BF.A1PV.01 0.12078283 0.06921834 0.05970319 0.16813008 0.11059648 ## TCGA.BF.A1PX.01 0.21398415 0.04019509 0.08906215 0.04499893 0.08561680 ##                        SE5          SE6          SE7        SE8        SE9 ## TCGA.3N.A9WB.06 0.06884572 6.495692e-02 4.610809e-03 0.16471168 0.08400658 ## TCGA.3N.A9WC.06 0.05623098 6.781589e-03 3.162253e-01 0.15964259 0.05873404 ## TCGA.3N.A9WD.06 0.02720647 8.345475e-02 9.239064e-02 0.07760029 0.05522884 ## TCGA.BF.A1PU.01 0.13404194 3.330034e-16 3.330034e-16 0.02543647 0.20449461 ## TCGA.BF.A1PV.01 0.14669963 1.677658e-01 1.260194e-03 0.06961553 0.08622790 ## TCGA.BF.A1PX.01 0.09930790 7.771710e-02 1.239738e-01 0.12590726 0.09923685"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_Bulk.html","id":"using-custom-model","dir":"Articles","previous_headings":"SE deconvolution","what":"Using custom model","title":"Recovery of Spatial Ecotypes from Bulk Gene Expression Data","text":"identifying SEs using SpatialEcoTyper MultiSpatialEcoTyper, users can develop Non-Negative Matrix Factorization (NMF) model deconvolve SEs bulk tissue samples, following tutorial . Users can create NMF model deconvolve SEs bulk gene expression data. training data can derived pseudo-bulk mixtures created aggregating single-cell transcriptomics data. tutorial, generate pseudo-bulk mixtures using single-cell RNA-seq data melanoma sample, also featured Recovery Spatial Ecotypes Single-Cell Gene Expression Data. raw count sample available WU2161_counts.tsv SE recovery results available WU2161_RecoveredSEs.tsv. Loading data Note: demonstration purposes, used 1,337 cells grouped SEs create pseudo-bulk mixtures. limited cell number offers basic example, may fully capture diverse characteristics SEs, potentially affecting robustness model training subsequent SE recovery. practice, recommend using comprehensive dataset accurately reflects properties SEs, ensuring training process results reliable recovery model. Creating pseudobulk data CreatePseudobulks function used create pseudo-bulk mixtures single-cell (spatial) transcriptomics data cells grouped SEs. samples cell fractions Gaussian distribution, sets negative fractions 0 re-normalizes fractions sum 1 across SEs. Based resulting fractions, samples 1,000 cells per pseudo-bulk mixture replacement, aggregates transcriptomes non-log linear space, normalize resulting mixture logarithm CPM using Seurat’s NormalizeData. Training NMFGenerateW function used train NMF model SE deconvolution based provided SE fractions gene expression matrix. applying NMF, gene’s expression scaled mean 0 unit variance (recommended). meet non-negativity requirement NMF, expression matrix transformed using posneg method. transformation splits expression matrix two matrices: one containing positive values containing absolute values negative values. two matrices concatenated form final training data NMF model. resulting W matrix can used infer SE sbundances bulk gene expression profiles using DeconvoluteSE function. Deconvolution can use new model SE deconvolution specifying W parameter:","code":"# Download single-cell gene expression matrix and SE recovery results. # The downloads should be finished within 1min. drive_download(as_id(\"17VAeOnz6vTt2s0ZeTrK1kITdJ3Yus4ei\"), \"WU2161_counts.tsv\", overwrite = TRUE) drive_download(as_id(\"17kFjOHhmWxWAKm-LDqy6wV27o5lvz8L2\"), \"WU2161_RecoveredSEs.tsv\", overwrite = TRUE) # Load single-cell gene expression matrix. counts = fread(\"WU2161_counts.tsv\", sep = \"\\t\", data.table = FALSE) rownames(counts) = counts[, 1] ## Set the first column as row names counts = counts[, -1] ## Drop the first column head(counts[, 1:5])  # Load SE recovery results SEs = read.table(\"WU2161_RecoveredSEs.tsv\", sep = \"\\t\", row.names = 1, header = TRUE) SEs = SEs[match(colnames(counts), rownames(SEs)), 1] # extract SE predictions length(SEs) table(SEs) result = CreatePseudobulks(counts = counts, groups = SEs, n_mixtures = 100) head(result$Mixtures[, 1:5]) ## Gene expression matrix of pseudobulks head(result$Fracs) ## SE fractions in pseudobulks W = NMFGenerateW(t(result$Fracs), result$Mixtures) ## This step should be done within 1 min head(W) sefracs <- DeconvoluteSE(bulkdata, W = W)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_Bulk.html","id":"visualization-of-se-abundances","dir":"Articles","previous_headings":"","what":"Visualization of SE abundances","title":"Recovery of Spatial Ecotypes from Bulk Gene Expression Data","text":"","code":"library(grid) HeatmapView(sefracs, breaks = c(0, 0.15, 0.3),              show_row_names = FALSE, cluster_rows = TRUE)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_Bulk.html","id":"session-info","dir":"Articles","previous_headings":"","what":"Session info","title":"Recovery of Spatial Ecotypes from Bulk Gene Expression Data","text":"session info allows users replicate exact environment identify potential discrepancies package versions configurations might causing problems.","code":"sessionInfo() ## R version 4.4.1 (2024-06-14) ## Platform: aarch64-apple-darwin20 ## Running under: macOS 15.1 ##  ## Matrix products: default ## BLAS:   /Library/Frameworks/R.framework/Versions/4.4-arm64/Resources/lib/libRblas.0.dylib  ## LAPACK: /Library/Frameworks/R.framework/Versions/4.4-arm64/Resources/lib/libRlapack.dylib;  LAPACK version 3.12.0 ##  ## locale: ## [1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8 ##  ## time zone: America/Los_Angeles ## tzcode source: internal ##  ## attached base packages: ## [1] grid      parallel  stats     graphics  grDevices utils     datasets  ## [8] methods   base      ##  ## other attached packages: ##  [1] SpatialEcoTyper_1.0.0 NMF_0.28              Biobase_2.64.0        ##  [4] BiocGenerics_0.50.0   cluster_2.1.6         rngtools_1.5.2        ##  [7] registry_0.5-1        dplyr_1.1.4           RANN_2.6.2            ## [10] Matrix_1.7-0          data.table_1.16.0     Seurat_5.1.0          ## [13] SeuratObject_5.0.2    sp_2.1-4              googledrive_2.1.1     ##  ## loaded via a namespace (and not attached): ##   [1] RColorBrewer_1.1-3     shape_1.4.6.1          rstudioapi_0.16.0      ##   [4] jsonlite_1.8.8         magrittr_2.0.3         magick_2.8.5           ##   [7] spatstat.utils_3.1-0   rmarkdown_2.28         GlobalOptions_0.1.2    ##  [10] fs_1.6.4               ragg_1.3.2             vctrs_0.6.5            ##  [13] ROCR_1.0-11            spatstat.explore_3.3-2 htmltools_0.5.8.1      ##  [16] curl_5.2.2             sass_0.4.9             sctransform_0.4.1      ##  [19] parallelly_1.38.0      KernSmooth_2.23-24     bslib_0.8.0            ##  [22] htmlwidgets_1.6.4      desc_1.4.3             ica_1.0-3              ##  [25] plyr_1.8.9             plotly_4.10.4          zoo_1.8-12             ##  [28] cachem_1.1.0           igraph_2.0.3           iterators_1.0.14       ##  [31] mime_0.12              lifecycle_1.0.4        pkgconfig_2.0.3        ##  [34] R6_2.5.1               fastmap_1.2.0          clue_0.3-65            ##  [37] fitdistrplus_1.2-1     future_1.34.0          shiny_1.9.1            ##  [40] digest_0.6.37          colorspace_2.1-1       S4Vectors_0.42.1       ##  [43] patchwork_1.2.0        tensor_1.5             RSpectra_0.16-2        ##  [46] irlba_2.3.5.1          textshaping_0.4.0      progressr_0.14.0       ##  [49] fansi_1.0.6            spatstat.sparse_3.1-0  httr_1.4.7             ##  [52] polyclip_1.10-7        abind_1.4-5            compiler_4.4.1         ##  [55] gargle_1.5.2           doParallel_1.0.17      fastDummies_1.7.4      ##  [58] highr_0.11             MASS_7.3-60.2          rjson_0.2.22           ##  [61] tools_4.4.1            lmtest_0.9-40          httpuv_1.6.15          ##  [64] future.apply_1.11.2    goftest_1.2-3          glue_1.7.0             ##  [67] nlme_3.1-164           promises_1.3.0         gridBase_0.4-7         ##  [70] Rtsne_0.17             reshape2_1.4.4         generics_0.1.3         ##  [73] gtable_0.3.5           spatstat.data_3.1-2    tidyr_1.3.1            ##  [76] utf8_1.2.4             spatstat.geom_3.3-2    RcppAnnoy_0.0.22       ##  [79] foreach_1.5.2          ggrepel_0.9.6          pillar_1.9.0           ##  [82] stringr_1.5.1          spam_2.10-0            RcppHNSW_0.6.0         ##  [85] later_1.3.2            circlize_0.4.16        splines_4.4.1          ##  [88] lattice_0.22-6         survival_3.6-4         deldir_2.0-4           ##  [91] tidyselect_1.2.1       ComplexHeatmap_2.20.0  miniUI_0.1.1.1         ##  [94] pbapply_1.7-2          knitr_1.48             gridExtra_2.3          ##  [97] IRanges_2.38.1         scattermore_1.2        stats4_4.4.1           ## [100] xfun_0.47              matrixStats_1.4.1      stringi_1.8.4          ## [103] lazyeval_0.2.2         yaml_2.3.10            evaluate_0.24.0        ## [106] codetools_0.2-20       tibble_3.2.1           BiocManager_1.30.25    ## [109] cli_3.6.3              uwot_0.2.2             xtable_1.8-4           ## [112] reticulate_1.39.0      systemfonts_1.1.0      munsell_0.5.1          ## [115] jquerylib_0.1.4        Rcpp_1.0.13            globals_0.16.3         ## [118] spatstat.random_3.3-1  png_0.1-8              spatstat.univar_3.0-1  ## [121] pkgdown_2.1.0          ggplot2_3.5.1          dotCall64_1.1-1        ## [124] listenv_0.9.1          viridisLite_0.4.2      scales_1.3.0           ## [127] ggridges_0.5.6         crayon_1.5.3           leiden_0.4.3.1         ## [130] purrr_1.0.2            GetoptLong_1.0.5       rlang_1.1.4            ## [133] cowplot_1.1.3"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_Spatial.html","id":"se-recovery-from-single-cell-spatial-data","dir":"Articles","previous_headings":"","what":"SE recovery from single-cell spatial data","title":"Recovery of Spatial Ecotypes from Spatial Transcriptomics Data","text":"tutorial, demonstrate recover spatial ecotypes (SEs) single-cell spatial transcriptomics data profiled platforms MERSCOPE, CosMx SMI, Xenium. use subset melanoma MERSCOPE sample illustrate SE recovery process. expression data single-cell metadata can downloaded Google Drive. data, single cells categorized nine major cell types, including B cells, CD4+ T cells, CD8+ T cells, NK cells, plasma cells, macrophages, dendritic cells (DC), fibroblasts, endothelial cells. First load required packages vignette","code":"suppressPackageStartupMessages(library(dplyr)) suppressPackageStartupMessages(library(ggplot2)) suppressPackageStartupMessages(library(Seurat)) suppressPackageStartupMessages(library(data.table)) suppressPackageStartupMessages(library(googledrive)) library(SpatialEcoTyper)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_Spatial.html","id":"loading-data","dir":"Articles","previous_headings":"SE recovery from single-cell spatial data","what":"Loading data","title":"Recovery of Spatial Ecotypes from Spatial Transcriptomics Data","text":"Download demo data Google Drive: Load gene expression matrix meta data R.","code":"drive_deauth() # Disable Google sign-in requirement drive_download(as_id(\"13Rc5Rsu8jbnEYYfUse-xQ7ges51LcI7n\"), \"HumanMelanomaPatient1_subset_counts.tsv.gz\", overwrite = TRUE) drive_download(as_id(\"12xcZNhpT-xbhcG8kX1QAdTeM9TKeFAUW\"), \"HumanMelanomaPatient1_subset_scmeta.tsv\", overwrite = TRUE) # Load single-cell gene expression matrix. Rows are genes, columns are cells. scdata <- fread(\"HumanMelanomaPatient1_subset_counts.tsv.gz\",                  sep = \"\\t\",header = TRUE, data.table = FALSE) rownames(scdata) <- scdata[, 1] scdata <- as.matrix(scdata[, -1]) head(scdata[, 1:5]) ##          HumanMelanomaPatient1__cell_3655 HumanMelanomaPatient1__cell_3657 ## PDK4                                    0                                1 ## TNFRSF17                                0                                0 ## ICAM3                                   0                                0 ## FAP                                     1                                0 ## GZMB                                    0                                0 ## TSC2                                    0                                0 ##          HumanMelanomaPatient1__cell_3658 HumanMelanomaPatient1__cell_3660 ## PDK4                                    1                                0 ## TNFRSF17                                0                                0 ## ICAM3                                   0                                0 ## FAP                                     0                                0 ## GZMB                                    0                                0 ## TSC2                                    0                                0 ##          HumanMelanomaPatient1__cell_3661 ## PDK4                                    0 ## TNFRSF17                                0 ## ICAM3                                   0 ## FAP                                     0 ## GZMB                                    0 ## TSC2                                    0 # Load single-cell metadata, with at least three columns, including X, Y, and CellType scmeta <- read.table(\"HumanMelanomaPatient1_subset_scmeta.tsv\",                        sep = \"\\t\",header = TRUE, row.names = 1) scdata = scdata[, match(rownames(scmeta), colnames(scdata))]  head(scmeta[, c(\"X\", \"Y\", \"CellType\")]) ##                                         X         Y   CellType ## HumanMelanomaPatient1__cell_3655 1894.706 -6367.766 Fibroblast ## HumanMelanomaPatient1__cell_3657 1942.480 -6369.602 Fibroblast ## HumanMelanomaPatient1__cell_3658 1963.007 -6374.026 Fibroblast ## HumanMelanomaPatient1__cell_3660 1981.600 -6372.266 Fibroblast ## HumanMelanomaPatient1__cell_3661 1742.939 -6374.851 Fibroblast ## HumanMelanomaPatient1__cell_3663 1921.683 -6383.309 Fibroblast"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_Spatial.html","id":"data-normalization","dir":"Articles","previous_headings":"SE recovery from single-cell spatial data","what":"Data normalization","title":"Recovery of Spatial Ecotypes from Spatial Transcriptomics Data","text":"gene expression data normalized SE recovery. data can normalized using SCTransform NormalizeData. , normalizing using SCTransform normalization. recommend install glmGamPoi package faster computation.","code":"if(!\"glmGamPoi\" %in% installed.packages()){   BiocManager::install(\"glmGamPoi\") } tmpobj <- CreateSeuratObject(scdata) %>%       SCTransform(clip.range = c(-10, 10), verbose = FALSE)  seurat_version = as.integer(gsub(\"\\\\..*\", \"\", as.character(packageVersion(\"SeuratObject\")))) if(seurat_version<5){   normdata <- GetAssayData(tmpobj, \"data\") }else{   normdata <- tmpobj[[\"SCT\"]]$data } normdata <- NormalizeData(scdata)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_Spatial.html","id":"se-recovery","dir":"Articles","previous_headings":"SE recovery from single-cell spatial data","what":"SE recovery","title":"Recovery of Spatial Ecotypes from Spatial Transcriptomics Data","text":"RecoverSE function used assign single cells SEs. Users can either use default models recover predefined SEs use custom models recover newly defined SEs. Note: recover SEs single-cell data, must specify either celltypes se_results RecoverSE function. neither provided, assume input data represents spot-level spatial transcriptomics, SE abundances inferred directly spot. default NMF models trained discovery MERSCOPE data, encompassing five cancer types: melanoma, four carcinomas. models tailored nine distinct cell types: B cells, CD4+ T cells, CD8+ T cells, NK cells, plasma cells, macrophages, dendritic cells, fibroblasts, endothelial cells. model facilitates recovery SEs single-cell datasets, allowing cell-type-specific SE analysis. Thus, SE recovery using default models, cells query data grouped one “B”, “CD4T”, “CD8T”, “NK”, “Plasma”, “Macrophage”, “DC”, “Fibroblast”, “Endothelial”, case sensitive. cell types considered non-SE compartments. SE recovery, recommend use unified embedding spatial microregions performing de novo Spatial EcoTyper analysis, integrate gene expression spatial information. embedding enhance accuracy refinement SE recovery results. detailed tutorial Spatial EcoTyper analysis available Discovery Spatial Ecotypes Single-cell Spatial Dataset. demonstration purposes, used SpatialEcoTyper group cells spatial clusters resolution 10. practice, recommend experimenting multiple resolutions ensure robust reliable results. specify se_results RecoverSE function SE recovery. can also recover SEs without using spatial embedding, less accurate due lack spatial information. cell type annotations required case. Cells grouped one “B”, “CD4T”, “CD8T”, “NK”, “Plasma”, “Macrophage”, “DC”, “Fibroblast”, “Endothelial”, case sensitive. cell types considered non-SE compartments. use custom models, users first develop recovery models following tutorial Development SE Recovery Models. resulting models can used SE recovery. example model available SE_Recovery_W_list.rds. Using custom models specifying Ws argument:","code":"## make sure the cells are grouped into one of \"B\", \"CD4T\", \"CD8T\", \"NK\", \"Plasma\", \"Macrophage\", \"DC\", \"Fibroblast\", and \"Endothelial\". print(unique(scmeta$CellType)) ## [1] \"Fibroblast\"  \"Endothelial\" \"DC\"          \"Macrophage\"  \"CD8T\"        ## [6] \"CD4T\"        \"Plasma\"      \"NK\"          \"B\" ## Spatial EcoTyper analysis: it would take ~2 min emb = SpatialEcoTyper(normdata, scmeta, resolution = 10) emb$obj ## A seurat object including the spatial embedding ## An object of class Seurat  ## 2315 features across 2315 samples within 1 assay  ## Active assay: RNA (2315 features, 2315 variable features) ##  3 layers present: counts, data, scale.data ##  2 dimensional reductions calculated: pca, umap head(emb$metadata[, c(\"X\", \"Y\", \"CellType\", \"SE\")])  ## Single-cell meta data with SE annotations ##                                         X         Y   CellType   SE ## HumanMelanomaPatient1__cell_3655 1894.706 -6367.766 Fibroblast SE25 ## HumanMelanomaPatient1__cell_3657 1942.480 -6369.602 Fibroblast SE29 ## HumanMelanomaPatient1__cell_3658 1963.007 -6374.026 Fibroblast SE29 ## HumanMelanomaPatient1__cell_3660 1981.600 -6372.266 Fibroblast SE29 ## HumanMelanomaPatient1__cell_3661 1742.939 -6374.851 Fibroblast SE48 ## HumanMelanomaPatient1__cell_3663 1921.683 -6383.309 Fibroblast SE25 sepreds <- RecoverSE(normdata, se_results = emb) head(sepreds) ## HumanMelanomaPatient1__cell_3655 HumanMelanomaPatient1__cell_3657  ##                            \"SE1\"                            \"SE4\"  ## HumanMelanomaPatient1__cell_3658 HumanMelanomaPatient1__cell_3660  ##                            \"SE4\"                            \"SE4\"  ## HumanMelanomaPatient1__cell_3661 HumanMelanomaPatient1__cell_3663  ##                            \"SE3\"                            \"SE1\" ## make sure the cells are grouped into one of \"B\", \"CD4T\", \"CD8T\", \"NK\", \"Plasma\", \"Macrophage\", \"DC\", \"Fibroblast\", and \"Endothelial\". print(unique(scmeta$CellType)) sepreds <- RecoverSE(normdata, celltypes = scmeta$CellType) head(sepreds) # Download SE recovery model drive_download(as_id(\"171WaAe49babYB85Cn1FcoNNE-lzYp1T_\"), \"SE_Recovery_W_list.rds\", overwrite = TRUE) Ws <- readRDS(\"SE_Recovery_W_list.rds\") ## make sure the cell type names are consistent. print(unique(scmeta$CellType)) print(names(Ws)) sepreds <- RecoverSE(normdata, celltypes = scmeta$CellType, Ws = Ws)  ## If Spatial EcoTyper result is available, we recommend: sepreds <- RecoverSE(normdata, se_results = emb, Ws = Ws)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_Spatial.html","id":"visualization-of-ses-in-the-tissue","dir":"Articles","previous_headings":"SE recovery from single-cell spatial data","what":"Visualization of SEs in the tissue","title":"Recovery of Spatial Ecotypes from Spatial Transcriptomics Data","text":"","code":"## Add the recovery result into the meta data scmeta$RecoveredSE <- sepreds[rownames(scmeta)] ## Visualize the SE recovery results SpatialView(scmeta, by = \"RecoveredSE\")"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_Spatial.html","id":"recovery-of-spatial-ecotypes-from-visium-spatial-gene-expression-data","dir":"Articles","previous_headings":"","what":"Recovery of spatial ecotypes from Visium Spatial Gene Expression data","title":"Recovery of Spatial Ecotypes from Spatial Transcriptomics Data","text":"recover SEs Visium spatial transcriptomics data, first infer SE abundances spot. spot assigned SE highest inferred abundance, enabling spatial mapping SEs across tissue. tutorial, use breast cancer sample demonstrate SE recovery Visium data. expression data can accessed : V1_Breast_Cancer_Block_A_Section_1_filtered_feature_bc_matrix.h5, downloaded 10x Genomics datasets.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_Spatial.html","id":"loading-data-1","dir":"Articles","previous_headings":"Recovery of spatial ecotypes from Visium Spatial Gene Expression data","what":"Loading data","title":"Recovery of Spatial Ecotypes from Spatial Transcriptomics Data","text":"First, download data Google Drive Load expression data R using Read10X_h5 function Seurat package.","code":"drive_download(as_id(\"15D9LgvZmCZUfsL62cD67JMf8Jcq_UyuB\"), \"V1_Breast_Cancer_Block_A_Section_1_filtered_feature_bc_matrix.h5\", overwrite = TRUE) drive_download(as_id(\"15NTZc1HrW_gLS_pmi1ckYLw30kNarf4w\"), \"V1_Breast_Cancer_Block_A_Section_1_tissue_positions_list.csv\", overwrite = TRUE) ## This download should be done within 1 min. if(!\"hdf5r\" %in% installed.packages()) BiocManager::install(\"hdf5r\") require(\"hdf5r\") # Load Visium gene expression matrix. Rows are genes, columns are spots. dat <- Read10X_h5(\"V1_Breast_Cancer_Block_A_Section_1_filtered_feature_bc_matrix.h5\") # normalize the expression data dat <- NormalizeData(dat)  meta <- read.csv(\"V1_Breast_Cancer_Block_A_Section_1_tissue_positions_list.csv\",                   header = FALSE, row.names = 1) colnames(meta) <- c(\"tissue\", \"row\", \"col\", \"imagerow\", \"imagecol\") meta <- meta[colnames(dat), ] head(meta) ##                    tissue row col imagerow imagecol ## AAACAAGTATCTCCCA-1      1  50 102    15632    17782 ## AAACACCAATAACTGC-1      1  59  19    17734     6447 ## AAACAGAGCGACTCCT-1      1  14  94     7079    16716 ## AAACAGGGTCTATATT-1      1  47  13    14882     5637 ## AAACAGTGTTCCTGGG-1      1  73  43    21069     9712 ## AAACATTTCCCGGATT-1      1  61  97    18242    17091"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_Spatial.html","id":"se-recovery-1","dir":"Articles","previous_headings":"Recovery of spatial ecotypes from Visium Spatial Gene Expression data","what":"SE recovery","title":"Recovery of Spatial Ecotypes from Spatial Transcriptomics Data","text":"neither celltypes se_results specified, RecoverSE function assume input data gene--spot gene expression matrix infer SE abundances across spots. Users option either use default models recover predefined SEs apply custom models recover newly defined SEs. develop SE recovery models, users follow tutorial Developing SE Recovery Models. resulting models can used SE recovery. example model available SE_Recovery_W_list.rds. specifying Ws parameter (list cell-type-specific W matrices) RecoverSE function, custom models used recovering SEs.","code":"preds <- RecoverSE(dat) head(preds) ##                             SE1          SE2          SE3          SE4 ## AAACAAGTATCTCCCA-1 2.127701e-04 6.877800e-05 3.979458e-01 8.534547e-02 ## AAACACCAATAACTGC-1 1.321616e-01 6.347672e-02 4.580604e-02 9.893653e-02 ## AAACAGAGCGACTCCT-1 1.658118e-01 2.438595e-15 1.257332e-01 1.021615e-01 ## AAACAGGGTCTATATT-1 6.495088e-02 1.975689e-16 2.208619e-01 6.972421e-10 ## AAACAGTGTTCCTGGG-1 9.104830e-02 2.073793e-01 2.579438e-09 6.489594e-02 ## AAACATTTCCCGGATT-1 6.684999e-13 2.987802e-01 2.908525e-08 7.202254e-07 ##                             SE5          SE6          SE7          SE8 ## AAACAAGTATCTCCCA-1 1.162860e-01 1.723712e-16 3.026670e-01 2.078080e-02 ## AAACACCAATAACTGC-1 4.542600e-07 4.511416e-01 3.746409e-16 1.333849e-01 ## AAACAGAGCGACTCCT-1 7.829883e-03 3.928577e-05 3.462729e-01 2.635185e-04 ## AAACAGGGTCTATATT-1 8.604433e-03 1.976922e-16 7.055828e-01 1.739479e-09 ## AAACAGTGTTCCTGGG-1 1.529680e-06 2.947065e-01 2.356171e-15 1.632831e-01 ## AAACATTTCCCGGATT-1 1.993179e-11 1.996192e-01 3.022784e-16 2.576151e-01 ##                             SE9        nonSE ## AAACAAGTATCTCCCA-1 1.755819e-02 5.913523e-02 ## AAACACCAATAACTGC-1 4.131729e-03 7.096041e-02 ## AAACAGAGCGACTCCT-1 1.684507e-02 2.350429e-01 ## AAACAGGGTCTATATT-1 1.975689e-16 2.054490e-11 ## AAACAGTGTTCCTGGG-1 2.351639e-06 1.786829e-01 ## AAACATTTCCCGGATT-1 7.419167e-02 1.697931e-01 ## This step would take ~3 minutes to complete # Download SE recovery model drive_download(as_id(\"171WaAe49babYB85Cn1FcoNNE-lzYp1T_\"), \"SE_Recovery_W_list.rds\", overwrite = TRUE) Ws <- readRDS(\"SE_Recovery_W_list.rds\")  ## Using custom models by specifying the Ws argument preds <- RecoverSE(normdata, Ws = Ws) ## This step would take ~3 minutes to complete"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_Spatial.html","id":"visualization-of-ses-in-the-tissue-1","dir":"Articles","previous_headings":"Recovery of spatial ecotypes from Visium Spatial Gene Expression data","what":"Visualization of SEs in the tissue","title":"Recovery of Spatial Ecotypes from Spatial Transcriptomics Data","text":"spot can assigned SE highest inferred abundance, spatial mapping SEs can visualized using SpatialView function.","code":"meta$RecoveredSE = colnames(preds)[apply(preds, 1, which.max)] meta$Y = -meta$row SpatialView(meta, by = \"RecoveredSE\", X = \"col\", Y = \"Y\", pt.size = 2)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_Spatial.html","id":"session-info","dir":"Articles","previous_headings":"","what":"Session info","title":"Recovery of Spatial Ecotypes from Spatial Transcriptomics Data","text":"session info allows users replicate exact environment identify potential discrepancies package versions configurations might causing problems.","code":"sessionInfo() ## R version 4.4.1 (2024-06-14) ## Platform: aarch64-apple-darwin20 ## Running under: macOS 15.1 ##  ## Matrix products: default ## BLAS:   /Library/Frameworks/R.framework/Versions/4.4-arm64/Resources/lib/libRblas.0.dylib  ## LAPACK: /Library/Frameworks/R.framework/Versions/4.4-arm64/Resources/lib/libRlapack.dylib;  LAPACK version 3.12.0 ##  ## locale: ## [1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8 ##  ## time zone: America/Los_Angeles ## tzcode source: internal ##  ## attached base packages: ## [1] parallel  stats     graphics  grDevices utils     datasets  methods   ## [8] base      ##  ## other attached packages: ##  [1] hdf5r_1.3.11          SpatialEcoTyper_1.0.0 NMF_0.28              ##  [4] Biobase_2.64.0        BiocGenerics_0.50.0   cluster_2.1.6         ##  [7] rngtools_1.5.2        registry_0.5-1        RANN_2.6.2            ## [10] Matrix_1.7-0          googledrive_2.1.1     data.table_1.16.0     ## [13] Seurat_5.1.0          SeuratObject_5.0.2    sp_2.1-4              ## [16] ggplot2_3.5.1         dplyr_1.1.4           ##  ## loaded via a namespace (and not attached): ##   [1] RcppAnnoy_0.0.22            splines_4.4.1               ##   [3] later_1.3.2                 tibble_3.2.1                ##   [5] R.oo_1.26.0                 polyclip_1.10-7             ##   [7] fastDummies_1.7.4           lifecycle_1.0.4             ##   [9] doParallel_1.0.17           pals_1.9                    ##  [11] globals_0.16.3              lattice_0.22-6              ##  [13] MASS_7.3-60.2               magrittr_2.0.3              ##  [15] plotly_4.10.4               sass_0.4.9                  ##  [17] rmarkdown_2.28              jquerylib_0.1.4             ##  [19] yaml_2.3.10                 httpuv_1.6.15               ##  [21] glmGamPoi_1.16.0            sctransform_0.4.1           ##  [23] spam_2.10-0                 spatstat.sparse_3.1-0       ##  [25] reticulate_1.39.0           mapproj_1.2.11              ##  [27] cowplot_1.1.3               pbapply_1.7-2               ##  [29] RColorBrewer_1.1-3          maps_3.4.2                  ##  [31] zlibbioc_1.50.0             abind_1.4-5                 ##  [33] GenomicRanges_1.56.1        Rtsne_0.17                  ##  [35] purrr_1.0.2                 R.utils_2.12.3              ##  [37] GenomeInfoDbData_1.2.12     circlize_0.4.16             ##  [39] IRanges_2.38.1              S4Vectors_0.42.1            ##  [41] ggrepel_0.9.6               irlba_2.3.5.1               ##  [43] listenv_0.9.1               spatstat.utils_3.1-0        ##  [45] goftest_1.2-3               RSpectra_0.16-2             ##  [47] spatstat.random_3.3-1       fitdistrplus_1.2-1          ##  [49] parallelly_1.38.0           DelayedMatrixStats_1.26.0   ##  [51] pkgdown_2.1.0               DelayedArray_0.30.1         ##  [53] leiden_0.4.3.1              codetools_0.2-20            ##  [55] tidyselect_1.2.1            shape_1.4.6.1               ##  [57] farver_2.1.2                UCSC.utils_1.0.0            ##  [59] matrixStats_1.4.1           stats4_4.4.1                ##  [61] spatstat.explore_3.3-2      jsonlite_1.8.8              ##  [63] GetoptLong_1.0.5            progressr_0.14.0            ##  [65] ggridges_0.5.6              survival_3.6-4              ##  [67] iterators_1.0.14            systemfonts_1.1.0           ##  [69] foreach_1.5.2               tools_4.4.1                 ##  [71] ragg_1.3.2                  ica_1.0-3                   ##  [73] Rcpp_1.0.13                 glue_1.7.0                  ##  [75] SparseArray_1.4.8           gridExtra_2.3               ##  [77] xfun_0.47                   MatrixGenerics_1.16.0       ##  [79] GenomeInfoDb_1.40.1         withr_3.0.1                 ##  [81] BiocManager_1.30.25         fastmap_1.2.0               ##  [83] fansi_1.0.6                 digest_0.6.37               ##  [85] R6_2.5.1                    mime_0.12                   ##  [87] textshaping_0.4.0           colorspace_2.1-1            ##  [89] scattermore_1.2             tensor_1.5                  ##  [91] dichromat_2.0-0.1           spatstat.data_3.1-2         ##  [93] R.methodsS3_1.8.2           utf8_1.2.4                  ##  [95] tidyr_1.3.1                 generics_0.1.3              ##  [97] S4Arrays_1.4.1              httr_1.4.7                  ##  [99] htmlwidgets_1.6.4           uwot_0.2.2                  ## [101] pkgconfig_2.0.3             gtable_0.3.5                ## [103] ComplexHeatmap_2.20.0       lmtest_0.9-40               ## [105] XVector_0.44.0              htmltools_0.5.8.1           ## [107] dotCall64_1.1-1             clue_0.3-65                 ## [109] scales_1.3.0                png_0.1-8                   ## [111] spatstat.univar_3.0-1       knitr_1.48                  ## [113] rstudioapi_0.16.0           reshape2_1.4.4              ## [115] rjson_0.2.22                nlme_3.1-164                ## [117] curl_5.2.2                  cachem_1.1.0                ## [119] zoo_1.8-12                  GlobalOptions_0.1.2         ## [121] stringr_1.5.1               KernSmooth_2.23-24          ## [123] miniUI_0.1.1.1              desc_1.4.3                  ## [125] pillar_1.9.0                grid_4.4.1                  ## [127] vctrs_0.6.5                 promises_1.3.0              ## [129] xtable_1.8-4                evaluate_0.24.0             ## [131] cli_3.6.3                   compiler_4.4.1              ## [133] rlang_1.1.4                 crayon_1.5.3                ## [135] future.apply_1.11.2         labeling_0.4.3              ## [137] plyr_1.8.9                  fs_1.6.4                    ## [139] stringi_1.8.4               viridisLite_0.4.2           ## [141] deldir_2.0-4                gridBase_0.4-7              ## [143] munsell_0.5.1               lazyeval_0.2.2              ## [145] spatstat.geom_3.3-2         RcppHNSW_0.6.0              ## [147] patchwork_1.2.0             bit64_4.5.2                 ## [149] sparseMatrixStats_1.16.0    future_1.34.0               ## [151] shiny_1.9.1                 highr_0.11                  ## [153] SummarizedExperiment_1.34.0 ROCR_1.0-11                 ## [155] gargle_1.5.2                igraph_2.0.3                ## [157] bslib_0.8.0                 bit_4.5.0"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_scRNA.html","id":"overview","dir":"Articles","previous_headings":"","what":"Overview","title":"Recovery of Spatial Ecotypes from Single-Cell Gene Expression Data","text":"tutorial, illustrate recover spatial ecotypes (SEs) single-cell RNA-seq data. First load required packages vignette","code":"suppressPackageStartupMessages(library(dplyr)) suppressPackageStartupMessages(library(ggplot2)) suppressPackageStartupMessages(library(parallel)) suppressPackageStartupMessages(library(Seurat)) suppressPackageStartupMessages(library(data.table)) suppressPackageStartupMessages(library(googledrive)) library(SpatialEcoTyper)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_scRNA.html","id":"data-preparation","dir":"Articles","previous_headings":"","what":"Data preparation","title":"Recovery of Spatial Ecotypes from Single-Cell Gene Expression Data","text":"recovery process requires normalized gene expression matrix vector cell type annotations. seurat object demo data can accessed WU2161_seurat_obj.rds. First, load seurat object R: Next, normalize gene expression data using SCTransform NormalizeData. , normalizing using SCTransform. recommend install glmGamPoi package faster computation. , extract normalized gene expression matrix cell type annotations Seurat object. Sparse matrix .mtx format can imported using ReadMtx function Seurat package. demo data can accessed WU2161. cell type annotations available WU2161_celltype_ann.tsv. Tab-delimited files can loaded R using fread function data.table package. TSV file expression matrix can accessed WU2161_counts.tsv cell type annotations available WU2161_celltype_ann.tsv.","code":"drive_deauth() # Disable Google sign-in requirement drive_download(as_id(\"17356t3n4vY581hogyi0Gmz4Sj5v804Vz\"), \"WU2161_seurat_obj.rds\", overwrite = TRUE) # Load the seurat object obj <- readRDS(\"WU2161_seurat_obj.rds\") obj ## An object of class Seurat  ## 27425 features across 1337 samples within 1 assay  ## Active assay: RNA (27425 features, 2000 variable features) ##  3 layers present: counts, data, scale.data ##  2 dimensional reductions calculated: pca, umap # Cell type annotations unique(obj$CellType) ## [1] \"Macrophage\" \"B\"          \"CD4T\"       \"CD8T\"       \"Neuron\"     ## [6] \"Fibroblast\" \"Epithelial\" \"Plasma\" if(!\"glmGamPoi\" %in% installed.packages()){   BiocManager::install(\"glmGamPoi\") } obj <- SCTransform(obj, verbose = FALSE) seurat_version = as.integer(gsub(\"\\\\..*\", \"\", as.character(packageVersion(\"SeuratObject\")))) if(seurat_version<5){   normdata <- GetAssayData(obj, \"data\") }else{   normdata <- obj[[\"SCT\"]]$data } head(normdata[, 1:5]) ## 6 x 5 sparse Matrix of class \"dgCMatrix\" ##            AAACCTGCACATGACT-1 AAACCTGGTGGTCCGT-1 AAACCTGGTTTGTGTG-1 ## AL627309.1                  .                  .                  . ## AL627309.5                  .                  .                  . ## AP006222.2                  .                  .                  . ## LINC01409                   .                  .                  . ## LINC01128                   .                  .                  . ## LINC00115                   .                  .                  . ##            AAACCTGTCCGATATG-1 AAACCTGTCTAACGGT-1 ## AL627309.1                  .                  . ## AL627309.5                  .                  . ## AP006222.2                  .                  . ## LINC01409                   .                  . ## LINC01128                   .                  . ## LINC00115                   .                  . ctann = obj$CellType head(ctann) ## AAACCTGCACATGACT-1 AAACCTGGTGGTCCGT-1 AAACCTGGTTTGTGTG-1 AAACCTGTCCGATATG-1  ##       \"Macrophage\"                \"B\"             \"CD4T\"       \"Macrophage\"  ## AAACCTGTCTAACGGT-1 AAACGGGCACTTAAGC-1  ##                \"B\"             \"CD8T\" table(ctann) ## ctann ##          B       CD4T       CD8T Epithelial Fibroblast Macrophage     Neuron  ##         97        138        425        121         44        374         91  ##     Plasma  ##         47 ## Load the gene expression matrix scdata = ReadMtx(mtx = \"matrix.mtx\", features = \"features.tsv\",                   cells = \"barcodes.tsv\", feature.column = 1, cell.column = 1)  ## Normalize the data normdata = NormalizeData(scdata) head(normdata[, 1:5]) ## Load cell type annotation ctann = read.table(\"WU2161_celltype_ann.tsv\", sep = \"\\t\",                     header = TRUE, row.names = 1) ctann = ctann[match(colnames(normdata), rownames(ctann)), 1] table(ctann) ## Download data from google drive drive_download(as_id(\"17VAeOnz6vTt2s0ZeTrK1kITdJ3Yus4ei\"), \"WU2161_counts.tsv\", overwrite = TRUE) drive_download(as_id(\"17Ax4LMOClMBu6h_WUcwXtFw4HuIU8_AQ\"), \"WU2161_celltype_ann.tsv\", overwrite = TRUE) ## Load the gene expression matrix scdata = fread(\"WU2161_counts.tsv\", sep = \"\\t\", data.table = FALSE) rownames(scdata) = scdata[, 1] ## Set the first column as row names scdata = scdata[, -1] ## Drop the first column  ## Normalize the data normdata = NormalizeData(scdata) head(normdata[, 1:5]) ##            AAACCTGCACATGACT-1 AAACCTGGTGGTCCGT-1 AAACCTGGTTTGTGTG-1 ## AL627309.1                  0                  0                  0 ## AL627309.5                  0                  0                  0 ## AP006222.2                  0                  0                  0 ## AC114498.1                  0                  0                  0 ## AL669831.2                  0                  0                  0 ## LINC01409                   0                  0                  0 ##            AAACCTGTCCGATATG-1 AAACCTGTCTAACGGT-1 ## AL627309.1          0.0000000                  0 ## AL627309.5          0.2951209                  0 ## AP006222.2          0.0000000                  0 ## AC114498.1          0.0000000                  0 ## AL669831.2          0.0000000                  0 ## LINC01409           0.0000000                  0 ## Load cell type annotation ctann = read.table(\"WU2161_celltype_ann.tsv\", sep = \"\\t\",                     header = TRUE, row.names = 1) ctann = ctann[match(colnames(normdata), rownames(ctann)), 1] table(ctann) ## ctann ##          B       CD4T       CD8T Epithelial Fibroblast Macrophage     Plasma  ##         97        138        425        121         44        374         47  ##    Unknown  ##         91"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_scRNA.html","id":"se-recovery","dir":"Articles","previous_headings":"","what":"SE recovery","title":"Recovery of Spatial Ecotypes from Single-Cell Gene Expression Data","text":"RecoverSE function used assign single cells SEs. Users can either use default model recover predefined SEs use custom model recover newly defined SEs. Note: using RecoverSE single-cell RNA-seq data, essential specify celltypes parameter. cell type annotations provided, function assume input data corresponds bulk spatial transcriptomics (e.g., Visium), infer SE abundances spot. default NMF models trained discovery MERSCOPE data, encompassing five cancer types: melanoma, four carcinomas. models tailored nine distinct cell types: B cells, CD4+ T cells, CD8+ T cells, NK cells, plasma cells, macrophages, dendritic cells, fibroblasts, endothelial cells. model facilitates recovery SEs single-cell datasets, allowing cell-type-specific SE analysis. SE recovery, cells query data grouped one “B”, “CD4T”, “CD8T”, “NK”, “Plasma”, “Macrophage”, “DC”, “Fibroblast”, “Endothelial”, case sensitive. cell types considered non-SE compartments. use custom models, users first develop recovery models following tutorial Development SE Recovery Models. resulting models can used SE recovery. example model available SE_Recovery_W_list.rds. Download example models Load custom models Using custom models SE recovery specifying Ws argument.","code":"sepreds <- RecoverSE(normdata, celltypes = ctann) head(sepreds) ## AAACCTGCACATGACT-1 AAACCTGGTGGTCCGT-1 AAACCTGGTTTGTGTG-1 AAACCTGTCCGATATG-1  ##              \"SE8\"            \"nonSE\"              \"SE1\"              \"SE8\"  ## AAACCTGTCTAACGGT-1 AAACGGGCACTTAAGC-1  ##            \"nonSE\"            \"nonSE\" drive_download(as_id(\"171WaAe49babYB85Cn1FcoNNE-lzYp1T_\"), \"SE_Recovery_W_list.rds\", overwrite = TRUE) Ws <- readRDS(\"SE_Recovery_W_list.rds\") names(Ws) ## named list of W matrices ## [1] \"CD4T\"        \"CD8T\"        \"DC\"          \"Endothelial\" \"Fibroblast\"  ## [6] \"Macrophage\"  \"NK\"          \"Plasma\" head(Ws[[1]]) ## feature by SE matrix ##                  SE01      SE02      SE03      SE04      SE05      SE06 ## CD226__pos  0.4145936 0.2555579 0.3323735 0.3241147 0.2263783 0.3279133 ## CDKN1B__pos 0.5729663 0.4552065 0.5120732 0.4627805 0.4453117 0.5156023 ## CXCR4__pos  0.5865790 0.2771225 0.4093821 0.3607076 0.3589891 0.3937211 ## DUSP1__pos  0.4233067 0.3462390 0.2269798 0.1616814 0.3265539 0.2562118 ## KLF2__pos   0.5889618 0.2314586 0.3867504 0.2295206 0.2998234 0.5173246 ## ICAM2__pos  0.4593230 0.2611751 0.4427930 0.3143084 0.3679498 0.4532637 ##                  SE07      SE08      SE09      SE10      SE11 ## CD226__pos  0.2189382 0.3417897 0.2563481 0.2360192 0.2815938 ## CDKN1B__pos 0.4414750 0.4747166 0.4414508 0.3922732 0.3821411 ## CXCR4__pos  0.3751669 0.4456410 0.3023204 0.2629156 0.2729461 ## DUSP1__pos  0.3682236 0.2211759 0.1713413 0.1699067 0.1121763 ## KLF2__pos   0.3570251 0.4327206 0.1732251 0.2086729 0.2118797 ## ICAM2__pos  0.2660441 0.5494585 0.2878338 0.3711269 0.2575091 sepreds <- RecoverSE(normdata, celltypes = ctann, Ws = Ws) head(sepreds) ## AAACCTGCACATGACT-1 AAACCTGGTGGTCCGT-1 AAACCTGGTTTGTGTG-1 AAACCTGTCCGATATG-1  ##             \"SE10\"            \"nonSE\"             \"SE01\"             \"SE10\"  ## AAACCTGTCTAACGGT-1 AAACGGGCACTTAAGC-1  ##            \"nonSE\"             \"SE03\""},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_scRNA.html","id":"session-info","dir":"Articles","previous_headings":"","what":"Session info","title":"Recovery of Spatial Ecotypes from Single-Cell Gene Expression Data","text":"session info allows users replicate exact environment identify potential discrepancies package versions configurations might causing problems.","code":"sessionInfo() ## R version 4.4.1 (2024-06-14) ## Platform: aarch64-apple-darwin20 ## Running under: macOS 15.1 ##  ## Matrix products: default ## BLAS:   /Library/Frameworks/R.framework/Versions/4.4-arm64/Resources/lib/libRblas.0.dylib  ## LAPACK: /Library/Frameworks/R.framework/Versions/4.4-arm64/Resources/lib/libRlapack.dylib;  LAPACK version 3.12.0 ##  ## locale: ## [1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8 ##  ## time zone: America/Los_Angeles ## tzcode source: internal ##  ## attached base packages: ## [1] parallel  stats     graphics  grDevices utils     datasets  methods   ## [8] base      ##  ## other attached packages: ##  [1] SpatialEcoTyper_1.0.0 NMF_0.28              Biobase_2.64.0        ##  [4] BiocGenerics_0.50.0   cluster_2.1.6         rngtools_1.5.2        ##  [7] registry_0.5-1        RANN_2.6.2            Matrix_1.7-0          ## [10] googledrive_2.1.1     data.table_1.16.0     Seurat_5.1.0          ## [13] SeuratObject_5.0.2    sp_2.1-4              ggplot2_3.5.1         ## [16] dplyr_1.1.4           ##  ## loaded via a namespace (and not attached): ##   [1] RcppAnnoy_0.0.22            splines_4.4.1               ##   [3] later_1.3.2                 tibble_3.2.1                ##   [5] polyclip_1.10-7             fastDummies_1.7.4           ##   [7] lifecycle_1.0.4             doParallel_1.0.17           ##   [9] globals_0.16.3              lattice_0.22-6              ##  [11] MASS_7.3-60.2               magrittr_2.0.3              ##  [13] plotly_4.10.4               sass_0.4.9                  ##  [15] rmarkdown_2.28              jquerylib_0.1.4             ##  [17] yaml_2.3.10                 httpuv_1.6.15               ##  [19] glmGamPoi_1.16.0            sctransform_0.4.1           ##  [21] spam_2.10-0                 spatstat.sparse_3.1-0       ##  [23] reticulate_1.39.0           cowplot_1.1.3               ##  [25] pbapply_1.7-2               RColorBrewer_1.1-3          ##  [27] zlibbioc_1.50.0             abind_1.4-5                 ##  [29] GenomicRanges_1.56.1        Rtsne_0.17                  ##  [31] purrr_1.0.2                 circlize_0.4.16             ##  [33] GenomeInfoDbData_1.2.12     IRanges_2.38.1              ##  [35] S4Vectors_0.42.1            ggrepel_0.9.6               ##  [37] irlba_2.3.5.1               listenv_0.9.1               ##  [39] spatstat.utils_3.1-0        goftest_1.2-3               ##  [41] RSpectra_0.16-2             spatstat.random_3.3-1       ##  [43] fitdistrplus_1.2-1          parallelly_1.38.0           ##  [45] DelayedMatrixStats_1.26.0   pkgdown_2.1.0               ##  [47] DelayedArray_0.30.1         leiden_0.4.3.1              ##  [49] codetools_0.2-20            tidyselect_1.2.1            ##  [51] shape_1.4.6.1               UCSC.utils_1.0.0            ##  [53] matrixStats_1.4.1           stats4_4.4.1                ##  [55] spatstat.explore_3.3-2      jsonlite_1.8.8              ##  [57] GetoptLong_1.0.5            progressr_0.14.0            ##  [59] ggridges_0.5.6              survival_3.6-4              ##  [61] iterators_1.0.14            systemfonts_1.1.0           ##  [63] foreach_1.5.2               tools_4.4.1                 ##  [65] ragg_1.3.2                  ica_1.0-3                   ##  [67] Rcpp_1.0.13                 glue_1.7.0                  ##  [69] SparseArray_1.4.8           gridExtra_2.3               ##  [71] xfun_0.47                   MatrixGenerics_1.16.0       ##  [73] GenomeInfoDb_1.40.1         withr_3.0.1                 ##  [75] BiocManager_1.30.25         fastmap_1.2.0               ##  [77] fansi_1.0.6                 digest_0.6.37               ##  [79] R6_2.5.1                    mime_0.12                   ##  [81] textshaping_0.4.0           colorspace_2.1-1            ##  [83] scattermore_1.2             tensor_1.5                  ##  [85] spatstat.data_3.1-2         utf8_1.2.4                  ##  [87] tidyr_1.3.1                 generics_0.1.3              ##  [89] S4Arrays_1.4.1              httr_1.4.7                  ##  [91] htmlwidgets_1.6.4           uwot_0.2.2                  ##  [93] pkgconfig_2.0.3             gtable_0.3.5                ##  [95] ComplexHeatmap_2.20.0       lmtest_0.9-40               ##  [97] XVector_0.44.0              htmltools_0.5.8.1           ##  [99] dotCall64_1.1-1             clue_0.3-65                 ## [101] scales_1.3.0                png_0.1-8                   ## [103] spatstat.univar_3.0-1       knitr_1.48                  ## [105] rstudioapi_0.16.0           reshape2_1.4.4              ## [107] rjson_0.2.22                nlme_3.1-164                ## [109] curl_5.2.2                  cachem_1.1.0                ## [111] zoo_1.8-12                  GlobalOptions_0.1.2         ## [113] stringr_1.5.1               KernSmooth_2.23-24          ## [115] miniUI_0.1.1.1              desc_1.4.3                  ## [117] pillar_1.9.0                grid_4.4.1                  ## [119] vctrs_0.6.5                 promises_1.3.0              ## [121] xtable_1.8-4                evaluate_0.24.0             ## [123] cli_3.6.3                   compiler_4.4.1              ## [125] rlang_1.1.4                 crayon_1.5.3                ## [127] future.apply_1.11.2         plyr_1.8.9                  ## [129] fs_1.6.4                    stringi_1.8.4               ## [131] viridisLite_0.4.2           deldir_2.0-4                ## [133] gridBase_0.4-7              munsell_0.5.1               ## [135] lazyeval_0.2.2              spatstat.geom_3.3-2         ## [137] RcppHNSW_0.6.0              patchwork_1.2.0             ## [139] sparseMatrixStats_1.16.0    future_1.34.0               ## [141] shiny_1.9.1                 SummarizedExperiment_1.34.0 ## [143] ROCR_1.0-11                 gargle_1.5.2                ## [145] igraph_2.0.3                bslib_0.8.0"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/SingleSample.html","id":"overview","dir":"Articles","previous_headings":"","what":"Overview","title":"Discovery of Spatial Ecotypes from a Single Sample","text":"tutorial, illustrate perform de novo discovery spatially distinct cellular ecosystems (SEs) single-cell spatial transcriptomics dataset using SpatialEcoTyper. analyzing single-cell spatial transcriptomics data melanoma sample (raw data available Vizgen’s MERSCOPE FFPE Human Immuno-oncology). quickly demonstrate SpatialEcoTyper works, ’ve selected subset sample, can downloaded . demo data comprises spatial expression 500 genes across 27,907 cells, categorized ten distinct cell types: B cells, CD4+ T cells, CD8+ T cells, NK cells, plasma cells, macrophages, dendritic cells (DC), fibroblasts, endothelial cells, cancer cell origin (CCOs). Given large proportion CCOs, order reduce running time, CCOs excluded demonstration. Besides, cells grouped four regions, including tumor, inner margin, outer margin, stroma. tumor stroma regions defined based density CCOs. detailed information tumor stroma annotations, please refer CytoSPACE paper. inner outer margins delineated regions extending 250 μm inside outside tumor boundaries, respectively. addition, assessed distance single cell tumor/stroma interface computing shortest Euclidean distance tumor regions (stromal regions) cells localized stromal region (tumor regions). positive distance used cells localized tumor region, negative distance used cells localized stroma region. SpatialEcoTyper analysis requires two input data: gene expression matrix: rows represent gene names columns represent cell IDs meta data: data frame least three columns, including “X” (X-coordinate), “Y” (Y-coordinate), “CellType” (cell type annotation). row names meta data match column names (cell IDs) expression matrix. First load required packages vignette","code":"suppressPackageStartupMessages(library(dplyr)) suppressPackageStartupMessages(library(ggplot2)) suppressPackageStartupMessages(library(parallel)) suppressPackageStartupMessages(library(Seurat)) suppressPackageStartupMessages(library(data.table)) suppressPackageStartupMessages(library(googledrive)) suppressPackageStartupMessages(library(R.utils))  library(SpatialEcoTyper)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/SingleSample.html","id":"loading-data","dir":"Articles","previous_headings":"","what":"Loading data","title":"Discovery of Spatial Ecotypes from a Single Sample","text":"Download data Google Drive Large text files can loaded R using fread function data.table package. SpatialEcoTyper supports sparse matrix input. Mtx files can loaded R using ReadMtx function Seurat package.","code":"drive_deauth() # Disable Google sign-in requirement drive_download(as_id(\"13Rc5Rsu8jbnEYYfUse-xQ7ges51LcI7n\"), \"HumanMelanomaPatient1_subset_counts.tsv.gz\", overwrite = TRUE) drive_download(as_id(\"12xcZNhpT-xbhcG8kX1QAdTeM9TKeFAUW\"), \"HumanMelanomaPatient1_subset_scmeta.tsv\", overwrite = TRUE) # Load single-cell gene expression matrix. Rows represent gene names and columns represent cell IDs scdata <- fread(\"HumanMelanomaPatient1_subset_counts.tsv.gz\",                  sep = \"\\t\",header = TRUE, data.table = FALSE) rownames(scdata) <- scdata[, 1]  # Setting the first column as row names scdata <- as.matrix(scdata[, -1]) # Dropping first column head(scdata[, 1:5]) ##          HumanMelanomaPatient1__cell_3655 HumanMelanomaPatient1__cell_3657 ## PDK4                                    0                                1 ## TNFRSF17                                0                                0 ## ICAM3                                   0                                0 ## FAP                                     1                                0 ## GZMB                                    0                                0 ## TSC2                                    0                                0 ##          HumanMelanomaPatient1__cell_3658 HumanMelanomaPatient1__cell_3660 ## PDK4                                    1                                0 ## TNFRSF17                                0                                0 ## ICAM3                                   0                                0 ## FAP                                     0                                0 ## GZMB                                    0                                0 ## TSC2                                    0                                0 ##          HumanMelanomaPatient1__cell_3661 ## PDK4                                    0 ## TNFRSF17                                0 ## ICAM3                                   0 ## FAP                                     0 ## GZMB                                    0 ## TSC2                                    0 # Load single-cell metadata # Three columns are required, including \"X\", \"Y\", and \"CellType\" # The row names should match the cell ids in the expression matrix scmeta <- read.table(\"HumanMelanomaPatient1_subset_scmeta.tsv\",                        sep = \"\\t\",header = TRUE, row.names = 1) scmeta <- scmeta[match(colnames(scdata), rownames(scmeta)), ] # match the cell ids in scdata and scmeta head(scmeta[, c(\"X\", \"Y\", \"CellType\")]) ##                                         X         Y   CellType ## HumanMelanomaPatient1__cell_3655 1894.706 -6367.766 Fibroblast ## HumanMelanomaPatient1__cell_3657 1942.480 -6369.602 Fibroblast ## HumanMelanomaPatient1__cell_3658 1963.007 -6374.026 Fibroblast ## HumanMelanomaPatient1__cell_3660 1981.600 -6372.266 Fibroblast ## HumanMelanomaPatient1__cell_3661 1742.939 -6374.851 Fibroblast ## HumanMelanomaPatient1__cell_3663 1921.683 -6383.309 Fibroblast drive_download(as_id(\"13M3xhRxp0xK9gf5F4DE9idSBFqVQIXDT\"), \"HumanMelanomaPatient1_subset_counts.mtx.gz\", overwrite = TRUE) drive_download(as_id(\"136feRaFjMtNvduLTm5xqa3WhyyoG4Xzo\"), \"HumanMelanomaPatient1_subset_cells.tsv.gz\", overwrite = TRUE) drive_download(as_id(\"13QprWzJhzzUy_w3XSrjlt9pjf2n-G7HV\"), \"HumanMelanomaPatient1_subset_genes.tsv.gz\", overwrite = TRUE)  scdata <- ReadMtx(mtx = \"HumanMelanomaPatient1_subset_counts.mtx.gz\",                    cells = \"HumanMelanomaPatient1_subset_cells.tsv.gz\",                    features = \"HumanMelanomaPatient1_subset_genes.tsv.gz\",                   feature.column = 1, cell.column = 1)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/SingleSample.html","id":"data-normalization","dir":"Articles","previous_headings":"","what":"Data normalization","title":"Discovery of Spatial Ecotypes from a Single Sample","text":"gene expression data normalized SpatialEcoTyper analysis. data can normalized using NormalizeData SCTransform. , normalizing using SCTransform normalization. recommend install glmGamPoi package faster computation.","code":"if(!\"glmGamPoi\" %in% installed.packages()){   BiocManager::install(\"glmGamPoi\") } tmpobj <- CreateSeuratObject(scdata) %>%       SCTransform(clip.range = c(-10, 10), verbose = FALSE)  seurat_version = as.integer(gsub(\"\\\\..*\", \"\", as.character(packageVersion(\"SeuratObject\")))) if(seurat_version<5){   normdata <- GetAssayData(tmpobj, \"data\") }else{   normdata <- tmpobj[[\"SCT\"]]$data } normdata <- NormalizeData(scdata)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/SingleSample.html","id":"preview-of-the-sample","dir":"Articles","previous_headings":"","what":"Preview of the sample","title":"Discovery of Spatial Ecotypes from a Single Sample","text":"SpatialView function can used visualize single cells spatial space, cell type region.   SpatialView function can also used visualize continuous characteristics, minimum distance single cell tumor/stroma margin. , positive distances indicate cells located within tumor region, negative distances denote cells within stroma.","code":"# Visualize the cell type annotations in the tissue SpatialView(scmeta, by = \"CellType\") + scale_color_manual(values = pals::cols25()) # Visualize the regions in the tissue SpatialView(scmeta, by = \"Region\") + scale_color_brewer(type = \"qual\", palette = \"Set1\") # Visualize the distance to tumor margin SpatialView(scmeta, by = \"Dist2Interface\") +    scale_colour_gradient2(low = \"#5e3c99\", high = \"#e66101\",                           mid = \"#d9d9d9\", midpoint = 0) +    labs(color = \"Distance to\\ntumor margin\")"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/SingleSample.html","id":"se-discovery-using-spatialecotyper","dir":"Articles","previous_headings":"","what":"SE discovery using SpatialEcoTyper","title":"Discovery of Spatial Ecotypes from a Single Sample","text":"SpatialEcoTyper function designed identify spatial ecotypes (SEs) single-cell spatial transcriptomics data. workflow begins grouping spatially co-localized single cells microregions, cell-type-specific gene expression profiles (GEPs) constructed microregion. Following , similarity networks microregions constructed based cell type-specific GEPs. integrate networks, SpatialEcoTyper utilizes Similarity Network Fusion (SNF) method, originally developed multi-omics data integration (Wang et al., 2014). fused similarity network enables identification SEs clustering. normdata matrix representing normalized gene expression data, rows correspond genes columns correspond cells. metadata data frame containing metadata associated cell. Must include spatial coordinates (e.g., X Y) well cell type annotations. row names must match column names normdata. outprefix Character string specifying prefix output file names. radius Numeric specifying radius (default: 50 µm) defining spatial microregion. minibatch Integer specifying number columns process minibatch SNF analysis. Default 5000. option splits matrix smaller chunks (minibatch), thus reducing memory usage. ncores Integer specifying number CPU cores use parallel processing. can type ?SpatialEcoTyper visualize full manual. real-world single-cell ST datasets 100,000 cells, analysis can time- memory-intensive. speed process, can increase number cores used (ncores), also increase memory consumption. limited computational memory, several strategies reduce usage. One approach decrease minibatch size reduce number cores (ncores) allocated. However, larger datasets, minimum memory requirement may remain high. Another option increase binsize, reduces number spatial microregions. can significantly decrease memory usage downsampling ST data, potentially excluding many cells analysis though. ’re interested studying multicellular communities associated specific cell types, can use filter.region..celltypes argument focus microregions containing least one cell specified cell types. example, identify multicellular communities related T cells, can use following command. ’re interested regions composed multiple cell types, can use min.cts.per.region argument specify minimum number distinct cell types required microregion included analysis.","code":"## This step takes ~2 minutes to complete on macOS with an Apple M1 Pro chip and 16 GB memory. se_results <- SpatialEcoTyper(normdata, scmeta,                               outprefix = \"Melanoma1_subset\",                               radius = 50, ncores = 2) se_results <- SpatialEcoTyper(normdata, scmeta,                               outprefix = \"Melanoma1_subset\",                               radius = 50, ncores = 2,                               filter.region.by.celltypes = c(\"CD8T\", \"CD4T\")) se_results <- SpatialEcoTyper(normdata, scmeta,                               outprefix = \"Melanoma1_subset\",                               radius = 50, ncores = 2,                               min.cts.per.region = 2)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/SingleSample.html","id":"spatialecotyper-result","dir":"Articles","previous_headings":"","what":"SpatialEcoTyper result","title":"Discovery of Spatial Ecotypes from a Single Sample","text":"outprefix specified, SpatialEcoTyper result saved RDS file named outprefix_SpatialEcoTyper_results.rds. result can loaded R using readRDS. SpatialEcoTyper result list includes two key components: Seurat object constructed integrated embedding spatial microregions, allowing detailed analysis visualization spatial architecture; data frame single-cell metadata, includes annotations discovered spatial ecotypes. annotations can used explore spatial distribution characteristics SEs within tissue.","code":"## drive_download(as_id(\"18AzHCtwwXoOM9_yRCjyfzcLQaWiQo1au\"), \"Melanoma1_subset_SpatialEcoTyper_results.rds\", overwrite = TRUE) se_results <- readRDS(\"Melanoma1_subset_SpatialEcoTyper_results.rds\") # Extract the Seurat object and updated single-cell metadata obj <- se_results$obj # A Seurat object scmeta <- se_results$metadata # Updated single-cell meta data, with SE annotation added head(scmeta) ##                                         X         Y   CellType CellTypeName ## HumanMelanomaPatient1__cell_3655 1894.706 -6367.766 Fibroblast  Fibroblasts ## HumanMelanomaPatient1__cell_3657 1942.480 -6369.602 Fibroblast  Fibroblasts ## HumanMelanomaPatient1__cell_3658 1963.007 -6374.026 Fibroblast  Fibroblasts ## HumanMelanomaPatient1__cell_3660 1981.600 -6372.266 Fibroblast  Fibroblasts ## HumanMelanomaPatient1__cell_3661 1742.939 -6374.851 Fibroblast  Fibroblasts ## HumanMelanomaPatient1__cell_3663 1921.683 -6383.309 Fibroblast  Fibroblasts ##                                  Region Dist2Interface  SE ## HumanMelanomaPatient1__cell_3655 Stroma      -883.1752 SE6 ## HumanMelanomaPatient1__cell_3657 Stroma      -894.8463 SE7 ## HumanMelanomaPatient1__cell_3658 Stroma      -904.1115 SE7 ## HumanMelanomaPatient1__cell_3660 Stroma      -907.8909 SE7 ## HumanMelanomaPatient1__cell_3661 Stroma      -874.2712 SE0 ## HumanMelanomaPatient1__cell_3663 Stroma      -903.6559 SE6 table(scmeta$SE) ## The number of cells in each SE ##  ##  SE0  SE1  SE2  SE3  SE4  SE5  SE6  SE7  ## 2847 6724 2773 5324 1857 3285 2856 2124"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/SingleSample.html","id":"embedding-of-spatial-architecture","dir":"Articles","previous_headings":"","what":"Embedding of spatial architecture","title":"Discovery of Spatial Ecotypes from a Single Sample","text":"spatial microregions’ embedding can visualized using standard Seurat functions DimPlot FeaturePlot. visualizations help explore spatial organization heterogeneity within tissue. Note: embedding clustering results differ slightly Seurat v4 v5. However, overall clustering patterns remain largely consistent, Adjusted Rand Index (ARI) 0.7 demonstration dataset. consistency ensures , despite minor variations, key biological insights preserved across versions.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/SingleSample.html","id":"visualizing-tumorstroma-regions-in-the-embedding","dir":"Articles","previous_headings":"Embedding of spatial architecture","what":"Visualizing tumor/stroma regions in the embedding","title":"Discovery of Spatial Ecotypes from a Single Sample","text":"","code":"DimPlot(obj, group.by = \"Region\") + scale_color_brewer(type = \"qual\", palette = \"Set1\")"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/SingleSample.html","id":"visualizing-the-distance-of-microregions-to-tumorstroma-interface","dir":"Articles","previous_headings":"Embedding of spatial architecture","what":"Visualizing the distance of microregions to tumor/stroma interface","title":"Discovery of Spatial Ecotypes from a Single Sample","text":"plot highlights distance spatial microregion tumor/stroma interface, revealing spatial continuum learnt SpatialEcoTyper. , positive distances indicate microregions located within tumor region, negative distances denote microregions within stroma.","code":"FeaturePlot(obj, \"Dist2Interface\", min.cutoff = -600, max.cutoff = 600) +    scale_colour_gradient2(low = \"#5e3c99\", high = \"#e66101\", mid = \"#d9d9d9\", midpoint = 0)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/SingleSample.html","id":"visualizing-spatial-ecotypes-in-the-embedding","dir":"Articles","previous_headings":"Embedding of spatial architecture","what":"Visualizing spatial ecotypes in the embedding","title":"Discovery of Spatial Ecotypes from a Single Sample","text":"plot visualizes SEs within spatial embedding. SEs represent distinct spatial microenvironments, unique cellular compositions spatial characteristics.","code":"DimPlot(obj, group.by = \"SE\") + scale_color_manual(values = pals::kelly()[-1])"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/SingleSample.html","id":"visualizing-the-most-abundant-cell-types-in-each-spatial-microregion","dir":"Articles","previous_headings":"Embedding of spatial architecture","what":"Visualizing the most abundant cell types in each spatial microregion","title":"Discovery of Spatial Ecotypes from a Single Sample","text":", focus visualizing dominant cell types within spatial microregion highlight characteristic cellular composition different SEs.","code":"DimPlot(obj, group.by = \"CellType\") +   scale_color_manual(values = pals::cols25())"},{"path":[]},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/SingleSample.html","id":"visualizing-ses-in-the-tissue","dir":"Articles","previous_headings":"SE characteristics","what":"Visualizing SEs in the tissue","title":"Discovery of Spatial Ecotypes from a Single Sample","text":"spatial distribution SEs within tissue can visualized using SpatialView function. visualization provides insights localization spatial organization different SEs across tissue section.  Note: NA values SE annotations denote cells excluded analysis, due absence neighboring cells insufficient number detected genes.","code":"SpatialView(scmeta, by = \"SE\")"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/SingleSample.html","id":"visualizing-the-cell-type-composition-of-ses","dir":"Articles","previous_headings":"SE characteristics","what":"Visualizing the cell type composition of SEs","title":"Discovery of Spatial Ecotypes from a Single Sample","text":"bar plot illustrates cell type composition within SE. visualization helps identify dominant cell types SE compare cellular makeup across different SEs.","code":"gg <- scmeta %>% filter(!is.na(SE)) %>% count(SE, CellType) ggplot(gg, aes(SE, n, fill = CellType)) +    geom_bar(stat = \"identity\", position = \"fill\") +   scale_fill_manual(values = pals::cols25()) +   theme_bw(base_size = 14) + coord_flip() +    labs(y = \"Cell type abundance\")"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/SingleSample.html","id":"visualizing-the-association-between-ses-and-pre-annotated-regions","dir":"Articles","previous_headings":"SE characteristics","what":"Visualizing the association between SEs and pre-annotated regions","title":"Discovery of Spatial Ecotypes from a Single Sample","text":"bar plot shows relationship SEs pre-annotated regions, tumor stroma. proportion SE associated regions displayed, providing insights SEs correspond different tissue regions.","code":"gg <- scmeta %>% filter(!is.na(SE)) %>% count(SE, Region) ggplot(gg, aes(SE, n, fill = Region)) +    geom_bar(stat = \"identity\", position = \"fill\") +    scale_fill_brewer(type = \"qual\", palette = \"Set1\") +   theme_bw(base_size = 14) + coord_flip() +    labs(y = \"Fraction\")"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/SingleSample.html","id":"visualizing-the-distance-of-ses-to-tumorstroma-interface","dir":"Articles","previous_headings":"SE characteristics","what":"Visualizing the distance of SEs to tumor/stroma interface","title":"Discovery of Spatial Ecotypes from a Single Sample","text":"box plot visualizes distribution distances SEs tumor/stroma interface. Positive distances indicate cells located within tumor region, negative distances denote cells within stroma. SEs ordered median distance, highlighting spatial localization relative tumor/stroma interface.","code":"gg <- scmeta %>% filter(!is.na(SE)) ## Order SEs by their distance to tumor/stroma interface tmp <-  gg %>% group_by(SE) %>% summarise(Mid = median(Dist2Interface)) %>% arrange(Mid) %>% pull(SE) gg$SE = factor(gg$SE, levels = tmp) ggplot(gg, aes(SE, Dist2Interface)) +    geom_boxplot() + theme_bw() + labs(y = \"Distance to tumor/stroma interface (μm)\")"},{"path":[]},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/SingleSample.html","id":"differential-expression-analysis","dir":"Articles","previous_headings":"Identification of cell-type-specific SE markers","what":"Differential expression analysis","title":"Discovery of Spatial Ecotypes from a Single Sample","text":"identify cell-type-specific SE markers, can perform differential expression analysis using presto package. example identify fibroblast-specific markers SE. Note: MERSCOPE data used SE discovery includes limited number genes. enhance analysis, can extend differential expression analysis whole transcriptome aligning scRNA-seq data spatial transcriptomics data via CytoSPACE.","code":"if(!\"presto\" %in% installed.packages()){    BiocManager::install(\"devtools\")   devtools::install_github(\"immunogenomics/presto\") } library(\"presto\")  # Ensure the normalized data is aligned with the single-cell metadata normdata = normdata[, rownames(scmeta)]  # Perform differential expression analysis for fibroblasts across SEs idx = which(scmeta$CellType==\"Fibroblast\" & !is.na(scmeta$SE)) degs = wilcoxauc(normdata[, idx], scmeta$SE[idx])  # Filter for significant markers with positive log-fold change degs = degs %>% filter(logFC>0 & pval<0.05) %>% arrange(desc(logFC)) head(degs) ##   feature group  avgExpr     logFC statistic       auc          pval ## 1   ACTA2   SE7 2.269714 1.9200869   4826706 0.7719666 6.157041e-196 ## 2 PLA2G2A   SE0 2.076013 1.4444331   9636530 0.8226676  0.000000e+00 ## 3 PLA2G2A   SE6 2.177647 1.4145934   5418244 0.7996960 2.595786e-219 ## 4     PKM   SE4 2.592488 1.3997410   3527900 0.8820820 1.875924e-178 ## 5     FN1   SE3 3.124745 1.1463924   5771112 0.7979963 4.778744e-193 ## 6 HLA-DRA   SE3 1.711258 0.9756877   5434388 0.7514360 8.958194e-160 ##            padj   pct_in  pct_out ## 1 8.455670e-194 69.35897 30.37675 ## 2  0.000000e+00 90.22005 34.38547 ## 3 1.069464e-216 88.39390 40.08561 ## 4 3.864404e-176 98.75260 81.20265 ## 5 4.922107e-191 98.03922 88.25844 ## 6 6.151293e-158 86.05664 43.91978"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/SingleSample.html","id":"visualizing-the-expression-of-cell-state-markers","dir":"Articles","previous_headings":"Identification of cell-type-specific SE markers","what":"Visualizing the expression of cell state markers","title":"Discovery of Spatial Ecotypes from a Single Sample","text":"’ve identified potential markers, can visualize expression across SEs. example using ACTA2 gene.  can also visualize expression marker (e.g., ACTA2) tissue.","code":"## Gene expression across all SEs gg <- scmeta[idx, ] gg$Expression <- normdata[\"ACTA2\", idx] ggplot(gg, aes(SE, Expression)) + geom_boxplot() +    theme_classic(base_size = 14) + ylab(\"ACTA2 expression\") ## Visualize gene expression in spatial gg <- scmeta gg$Expression <- normdata[\"ACTA2\", ] SpatialView(gg, by = \"Expression\") + scale_color_viridis_c() +    labs(color = \"ACTA2\\nexpression\")"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/SingleSample.html","id":"session-info","dir":"Articles","previous_headings":"","what":"Session info","title":"Discovery of Spatial Ecotypes from a Single Sample","text":"session info allows users replicate exact environment identify potential discrepancies package versions configurations might causing problems.","code":"sessionInfo() ## R version 4.4.1 (2024-06-14) ## Platform: aarch64-apple-darwin20 ## Running under: macOS 15.1 ##  ## Matrix products: default ## BLAS:   /Library/Frameworks/R.framework/Versions/4.4-arm64/Resources/lib/libRblas.0.dylib  ## LAPACK: /Library/Frameworks/R.framework/Versions/4.4-arm64/Resources/lib/libRlapack.dylib;  LAPACK version 3.12.0 ##  ## locale: ## [1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8 ##  ## time zone: America/Los_Angeles ## tzcode source: internal ##  ## attached base packages: ## [1] parallel  stats     graphics  grDevices utils     datasets  methods   ## [8] base      ##  ## other attached packages: ##  [1] presto_1.0.0          Rcpp_1.0.13           SpatialEcoTyper_1.0.0 ##  [4] NMF_0.28              Biobase_2.64.0        BiocGenerics_0.50.0   ##  [7] cluster_2.1.6         rngtools_1.5.2        registry_0.5-1        ## [10] RANN_2.6.2            Matrix_1.7-0          R.utils_2.12.3        ## [13] R.oo_1.26.0           R.methodsS3_1.8.2     googledrive_2.1.1     ## [16] data.table_1.16.0     Seurat_5.1.0          SeuratObject_5.0.2    ## [19] sp_2.1-4              ggplot2_3.5.1         dplyr_1.1.4           ##  ## loaded via a namespace (and not attached): ##   [1] RcppAnnoy_0.0.22            splines_4.4.1               ##   [3] later_1.3.2                 tibble_3.2.1                ##   [5] polyclip_1.10-7             fastDummies_1.7.4           ##   [7] lifecycle_1.0.4             doParallel_1.0.17           ##   [9] pals_1.9                    globals_0.16.3              ##  [11] lattice_0.22-6              MASS_7.3-60.2               ##  [13] magrittr_2.0.3              plotly_4.10.4               ##  [15] sass_0.4.9                  rmarkdown_2.28              ##  [17] jquerylib_0.1.4             yaml_2.3.10                 ##  [19] httpuv_1.6.15               glmGamPoi_1.16.0            ##  [21] sctransform_0.4.1           spam_2.10-0                 ##  [23] spatstat.sparse_3.1-0       reticulate_1.39.0           ##  [25] mapproj_1.2.11              cowplot_1.1.3               ##  [27] pbapply_1.7-2               RColorBrewer_1.1-3          ##  [29] maps_3.4.2                  zlibbioc_1.50.0             ##  [31] abind_1.4-5                 GenomicRanges_1.56.1        ##  [33] Rtsne_0.17                  purrr_1.0.2                 ##  [35] GenomeInfoDbData_1.2.12     circlize_0.4.16             ##  [37] IRanges_2.38.1              S4Vectors_0.42.1            ##  [39] ggrepel_0.9.6               irlba_2.3.5.1               ##  [41] listenv_0.9.1               spatstat.utils_3.1-0        ##  [43] goftest_1.2-3               RSpectra_0.16-2             ##  [45] spatstat.random_3.3-1       fitdistrplus_1.2-1          ##  [47] parallelly_1.38.0           DelayedMatrixStats_1.26.0   ##  [49] pkgdown_2.1.0               DelayedArray_0.30.1         ##  [51] leiden_0.4.3.1              codetools_0.2-20            ##  [53] tidyselect_1.2.1            shape_1.4.6.1               ##  [55] farver_2.1.2                UCSC.utils_1.0.0            ##  [57] matrixStats_1.4.1           stats4_4.4.1                ##  [59] spatstat.explore_3.3-2      jsonlite_1.8.8              ##  [61] GetoptLong_1.0.5            progressr_0.14.0            ##  [63] ggridges_0.5.6              survival_3.6-4              ##  [65] iterators_1.0.14            systemfonts_1.1.0           ##  [67] foreach_1.5.2               tools_4.4.1                 ##  [69] ragg_1.3.2                  ica_1.0-3                   ##  [71] glue_1.7.0                  SparseArray_1.4.8           ##  [73] gridExtra_2.3               xfun_0.47                   ##  [75] MatrixGenerics_1.16.0       GenomeInfoDb_1.40.1         ##  [77] withr_3.0.1                 BiocManager_1.30.25         ##  [79] fastmap_1.2.0               fansi_1.0.6                 ##  [81] digest_0.6.37               R6_2.5.1                    ##  [83] mime_0.12                   textshaping_0.4.0           ##  [85] colorspace_2.1-1            scattermore_1.2             ##  [87] tensor_1.5                  dichromat_2.0-0.1           ##  [89] spatstat.data_3.1-2         utf8_1.2.4                  ##  [91] tidyr_1.3.1                 generics_0.1.3              ##  [93] S4Arrays_1.4.1              httr_1.4.7                  ##  [95] htmlwidgets_1.6.4           uwot_0.2.2                  ##  [97] pkgconfig_2.0.3             gtable_0.3.5                ##  [99] ComplexHeatmap_2.20.0       lmtest_0.9-40               ## [101] XVector_0.44.0              htmltools_0.5.8.1           ## [103] dotCall64_1.1-1             clue_0.3-65                 ## [105] scales_1.3.0                png_0.1-8                   ## [107] spatstat.univar_3.0-1       knitr_1.48                  ## [109] rstudioapi_0.16.0           reshape2_1.4.4              ## [111] rjson_0.2.22                nlme_3.1-164                ## [113] curl_5.2.2                  cachem_1.1.0                ## [115] zoo_1.8-12                  GlobalOptions_0.1.2         ## [117] stringr_1.5.1               KernSmooth_2.23-24          ## [119] miniUI_0.1.1.1              desc_1.4.3                  ## [121] pillar_1.9.0                grid_4.4.1                  ## [123] vctrs_0.6.5                 promises_1.3.0              ## [125] xtable_1.8-4                evaluate_0.24.0             ## [127] cli_3.6.3                   compiler_4.4.1              ## [129] rlang_1.1.4                 crayon_1.5.3                ## [131] future.apply_1.11.2         labeling_0.4.3              ## [133] plyr_1.8.9                  fs_1.6.4                    ## [135] stringi_1.8.4               viridisLite_0.4.2           ## [137] deldir_2.0-4                gridBase_0.4-7              ## [139] munsell_0.5.1               lazyeval_0.2.2              ## [141] spatstat.geom_3.3-2         RcppHNSW_0.6.0              ## [143] patchwork_1.2.0             sparseMatrixStats_1.16.0    ## [145] future_1.34.0               shiny_1.9.1                 ## [147] highr_0.11                  SummarizedExperiment_1.34.0 ## [149] ROCR_1.0-11                 gargle_1.5.2                ## [151] igraph_2.0.3                bslib_0.8.0"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/TrainRecoveryModels.html","id":"development-of-se-recovery-model","dir":"Articles","previous_headings":"","what":"Development of SE recovery model","title":"Development of NMF Models for Spatial Ecotype Recovery","text":"performing Spatial EcoTyper analysis, users can develop machine learning model recover spatial ecotypes (SEs) various types gene expression data, including spatial transcriptomics single-cell RNA-seq. tutorial, use Vizgen MERSCOPE data two samples demonstrate training process. gene expression matrices, cell type SE annotations required training can obtained . First load required packages vignette","code":"suppressPackageStartupMessages(library(googledrive)) suppressPackageStartupMessages(library(Seurat)) suppressPackageStartupMessages(library(NMF)) suppressPackageStartupMessages(library(data.table)) suppressPackageStartupMessages(library(dplyr)) library(SpatialEcoTyper)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/TrainRecoveryModels.html","id":"loading-data","dir":"Articles","previous_headings":"Development of SE recovery model","what":"Loading data","title":"Development of NMF Models for Spatial Ecotype Recovery","text":"Download data Google Drive Load gene expression matrix Load cell type SE annotations","code":"drive_deauth() # Disable Google sign-in requirement drive_download(as_id(\"17mbc56M0GTq-9MR0GqHas-L-yIXdnxtu\"), \"HumanMelanomaPatient1_subset_counts.tsv.gz\", overwrite = TRUE) drive_download(as_id(\"17nL0ceONPw8ByAtDe34DiXiGLMVBLlPX\"), \"HumanColonCancerPatient2_subset_counts.tsv.gz\", overwrite = TRUE) drive_download(as_id(\"18HsreR4QH6hh5L-YO7toP9lg62dVv8iX\"), \"MultiSE_metadata_final.tsv\", overwrite = TRUE) ## Read the expression matrix for the first sample scdata <- fread(\"HumanMelanomaPatient1_subset_counts.tsv.gz\",                  sep = \"\\t\",header = TRUE, data.table = FALSE) rownames(scdata) <- scdata[, 1]  ## set the first column as row names scdata <- scdata[, -1]  ## drop the first column scdata <- NormalizeData(scdata)  ## Normalize the expression matrix  ## Read the expression matrix for the second sample scdata2 <- fread(\"HumanColonCancerPatient2_subset_counts.tsv.gz\",                  sep = \"\\t\",header = TRUE, data.table = FALSE) rownames(scdata2) <- scdata2[, 1]  ## set the first column as row names scdata2 <- scdata2[, -1]  ## drop the first column scdata2 <- NormalizeData(scdata2)  ## Normalize the expression matrix  ## Combine the two expression matrices genes <- intersect(rownames(scdata), rownames(scdata2)) scdata <- cbind(scdata[genes, ], scdata2[genes, ]) head(scdata[, 1:5]) ##          HumanMelanomaPatient1__cell_3655 HumanMelanomaPatient1__cell_3657 ## PDK4                             0.000000                         4.221184 ## TNFRSF17                         0.000000                         0.000000 ## ICAM3                            0.000000                         0.000000 ## FAP                              3.552438                         0.000000 ## GZMB                             0.000000                         0.000000 ## TSC2                             0.000000                         0.000000 ##          HumanMelanomaPatient1__cell_3658 HumanMelanomaPatient1__cell_3660 ## PDK4                             3.208945                                0 ## TNFRSF17                         0.000000                                0 ## ICAM3                            0.000000                                0 ## FAP                              0.000000                                0 ## GZMB                             0.000000                                0 ## TSC2                             0.000000                                0 ##          HumanMelanomaPatient1__cell_3661 ## PDK4                                    0 ## TNFRSF17                                0 ## ICAM3                                   0 ## FAP                                     0 ## GZMB                                    0 ## TSC2                                    0 ## Load the single-cell meta data derived from MultiSpatialEcoTyper analysis scmeta <- read.table(\"MultiSE_metadata_final.tsv\", sep = \"\\t\",                       header = TRUE, row.names = 1) scmeta$SE[is.na(scmeta$SE)] = \"nonSE\" ## cells with NA predictions were assigned into the NonSE group  ## Matches the row names of meta data and column names of expression matrix cells <- intersect(colnames(scdata), rownames(scmeta)) scdata <- scdata[, cells] scmeta <- scmeta[cells, ] head(scmeta[, c(\"Sample\", \"CellType\", \"SE\")]) ##                                  Sample   CellType  SE ## HumanMelanomaPatient1__cell_3655   SKCM Fibroblast SE3 ## HumanMelanomaPatient1__cell_3657   SKCM Fibroblast SE4 ## HumanMelanomaPatient1__cell_3658   SKCM Fibroblast SE4 ## HumanMelanomaPatient1__cell_3660   SKCM Fibroblast SE4 ## HumanMelanomaPatient1__cell_3661   SKCM Fibroblast SE3 ## HumanMelanomaPatient1__cell_3663   SKCM Fibroblast SE3"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/TrainRecoveryModels.html","id":"training","dir":"Articles","previous_headings":"Development of SE recovery model","what":"Training","title":"Development of NMF Models for Spatial Ecotype Recovery","text":"NMFGenerateWList function used train cell-type specific NMF models recovering SEs. Prior NMF, gene scaled mean 0 unit variance within cell type-specific expression matrix. satisfy non-negativity requirement NMF, cell type-specific expression matrices individually processed using posneg transformation, converts expression matrix two matrices, one containing positive values containing negative values sign inverted. two matrices subsequently concatenated produce training data. NMFGenerateWList function return list feature × SE matrices, representing cell type-specific gene signature matrix rows features columns SEs. Note: default, NMFGenerateWList selects top 2000 variable features (nfeature argument) -samples 2500 cells (downsample argument) within cell type training. training, retains 50 genes per SE (nfeature.per.se argument) model. Users can tune parameters accordingly. resulting W matrices used recover SEs spatial transcriptomics single-cell RNA-seq using RecoverSE function. detailed documentation SE recovery available Recovery Spatial Ecotypes Single-Cell Gene Expression Data Recovery Spatial Ecotypes Spatial Transcriptomics Data.","code":"# training Ws = NMFGenerateWList(scdata, scmeta,                        CellType = \"CellType\",                       SE = \"SE\", Sample = \"Sample\") ## This step would take ~3 mins for the demo. class(Ws) ## [1] \"list\" names(Ws) ## [1] \"B\"           \"CD4T\"        \"CD8T\"        \"DC\"          \"Endothelial\" ## [6] \"Fibroblast\"  \"Macrophage\"  \"NK\"          \"Plasma\" head(Ws[[2]]) ##                   SE1       SE5       SE6      SE10       SE8       SE3 ## FOXP3__pos  0.4719930 0.4885273 0.3651733 0.6901381 0.8495508 0.5111029 ## CCL5__neg   0.4636977 0.5029325 0.4671653 0.5279928 0.6660964 0.5879144 ## NFKB2__neg  0.5959560 0.5353461 0.3610576 0.4095969 0.5328200 0.6356051 ## NFKBIA__neg 0.5449949 0.5124919 0.4053110 0.3867929 0.4872992 0.5444012 ## XBP1__neg   0.3641057 0.4390831 0.4536565 0.5994809 0.6964391 0.4286859 ## IRF3__neg   0.4771004 0.4980158 0.4737179 0.5178389 0.4861118 0.4835203 ##                   SE4       SE9       SE2       SE7 ## FOXP3__pos  0.7223714 0.4173739 0.5810581 0.5287318 ## CCL5__neg   0.7176785 0.3887930 0.5669015 0.7065557 ## NFKB2__neg  0.7882044 0.4825905 1.0177761 0.1657350 ## NFKBIA__neg 0.5245634 0.4819461 0.9273532 0.7001782 ## XBP1__neg   0.4714610 0.5722981 0.6128531 0.8757327 ## IRF3__neg   0.4070195 0.5213065 0.6902136 0.9023205"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/TrainRecoveryModels.html","id":"development-of-se-deconvolution-model","dir":"Articles","previous_headings":"","what":"Development of SE deconvolution model","title":"Development of NMF Models for Spatial Ecotype Recovery","text":"Users can also develop NMF model deconvolve SEs bulk gene expression data. training data can pseudo-bulk mixtures aggregating single-cell transcriptomics. tutorial, create pseudo-bulk mixtures single-cell RNA-seq data melanoma sample. raw count sample available WU2161_counts.tsv SE recovery results available WU2161_RecoveredSEs.tsv.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/TrainRecoveryModels.html","id":"loading-data-1","dir":"Articles","previous_headings":"Development of SE deconvolution model","what":"Loading data","title":"Development of NMF Models for Spatial Ecotype Recovery","text":"Note: demonstration purposes, used 1,337 cells grouped SEs create pseudo-bulk mixtures. limited cell number offers basic example, fully capture diverse characteristics SEs, potentially affecting robustness model training subsequent SE recovery. practice, recommend using comprehensive dataset accurately reflects properties SEs, ensuring training process results reliable recovery model.","code":"# Download single-cell gene expression matrix and SE recovery results. # The downloads should be finished within 1min. drive_download(as_id(\"17VAeOnz6vTt2s0ZeTrK1kITdJ3Yus4ei\"), \"WU2161_counts.tsv\", overwrite = TRUE) drive_download(as_id(\"17kFjOHhmWxWAKm-LDqy6wV27o5lvz8L2\"), \"WU2161_RecoveredSEs.tsv\", overwrite = TRUE) # Load single-cell gene expression matrix. counts = fread(\"WU2161_counts.tsv\", sep = \"\\t\", data.table = FALSE) rownames(counts) = counts[, 1] ## Set the first column as row names counts = counts[, -1] ## Drop the first column head(counts[, 1:5]) ##            AAACCTGCACATGACT-1 AAACCTGGTGGTCCGT-1 AAACCTGGTTTGTGTG-1 ## AL627309.1                  0                  0                  0 ## AL627309.5                  0                  0                  0 ## AP006222.2                  0                  0                  0 ## AC114498.1                  0                  0                  0 ## AL669831.2                  0                  0                  0 ## LINC01409                   0                  0                  0 ##            AAACCTGTCCGATATG-1 AAACCTGTCTAACGGT-1 ## AL627309.1                  0                  0 ## AL627309.5                  1                  0 ## AP006222.2                  0                  0 ## AC114498.1                  0                  0 ## AL669831.2                  0                  0 ## LINC01409                   0                  0 # Load SE recovery results SEs = read.table(\"WU2161_RecoveredSEs.tsv\", sep = \"\\t\", row.names = 1, header = TRUE) SEs = SEs[match(colnames(counts), rownames(SEs)), 1] # extract SE predictions length(SEs) ## [1] 1337 table(SEs) ## SEs ## nonSE   SE1   SE2   SE3   SE4   SE5   SE6   SE7   SE8   SE9  ##   912    71    45    24     5    43    74    75    71    17"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/TrainRecoveryModels.html","id":"creating-pseudobulk-data","dir":"Articles","previous_headings":"Development of SE deconvolution model","what":"Creating pseudobulk data","title":"Development of NMF Models for Spatial Ecotype Recovery","text":"CreatePseudobulks function used create pseudo-bulk mixtures single-cell (spatial) transcriptomics data cells grouped SEs. samples cell fractions Gaussian distribution, sets negative fractions 0 re-normalizes fractions sum 1 across SEs. Based resulting fractions, samples 1,000 cells per pseudo-bulk mixture replacement, aggregates transcriptomes non-log linear space, normalize resulting mixture logarithm CPM using Seurat’s NormalizeData.","code":"result = CreatePseudobulks(counts = counts, groups = SEs, n_mixtures = 100) ## This step took ~4 min for the demo. head(result$Mixtures[, 1:5]) ## Gene expression matrix of pseudobulks ##            Pseudobulk1  Pseudobulk2 Pseudobulk3  Pseudobulk4  Pseudobulk5 ## AL627309.1 0.020129003 0.0166225359 0.023307824 0.0098541618 0.0088996542 ## AL627309.5 0.042782118 0.0507958729 0.065149253 0.0307522233 0.0470043992 ## AP006222.2 0.001258585 0.0047970105 0.002820776 0.0005117182 0.0027994077 ## AC114498.1 0.001848058 0.0009235317 0.002770807 0.0018443685 0.0009235317 ## AL669831.2 0.000000000 0.0000000000 0.000000000 0.0000000000 0.0000000000 ## LINC01409  0.028300784 0.0323725374 0.042793627 0.0507739102 0.0274993034 head(result$Fracs) ## SE fractions in pseudobulks ##                  nonSE        SE1        SE2        SE3         SE4        SE5 ## Pseudobulk1 0.16490065 0.04918395 0.04180656 0.13380601 0.108023707 0.10246218 ## Pseudobulk2 0.06857820 0.14872621 0.11331726 0.11852688 0.051279421 0.09434107 ## Pseudobulk3 0.08345357 0.17803366 0.19856639 0.00000000 0.002316577 0.04424433 ## Pseudobulk4 0.09014638 0.07754488 0.06834655 0.06010091 0.080744805 0.11287459 ## Pseudobulk5 0.12412216 0.00000000 0.05709886 0.11705402 0.102333027 0.21175799 ## Pseudobulk6 0.04653528 0.07215946 0.05076475 0.13719262 0.114854678 0.17734928 ##                    SE6        SE7        SE8        SE9 ## Pseudobulk1 0.15013277 0.11912636 0.09232816 0.03822966 ## Pseudobulk2 0.10492044 0.08010585 0.09546042 0.12474424 ## Pseudobulk3 0.15682092 0.15585820 0.03024719 0.15045916 ## Pseudobulk4 0.13277544 0.06254595 0.17260478 0.14231574 ## Pseudobulk5 0.06920083 0.04372533 0.22512173 0.04958606 ## Pseudobulk6 0.06965773 0.16811845 0.02792748 0.13544026"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/TrainRecoveryModels.html","id":"training-1","dir":"Articles","previous_headings":"Development of SE deconvolution model","what":"Training","title":"Development of NMF Models for Spatial Ecotype Recovery","text":"NMFGenerateW function used train NMF model SE deconvolution based provided SE fractions gene expression matrix. applying NMF, gene’s expression scaled mean 0 unit variance default. meet non-negativity requirement NMF, expression matrix transformed using posneg method. transformation splits expression matrix two matrices: one containing positive values containing absolute values negative values. two matrices concatenated form final training data NMF model. Note: default, NMFGenerateW selects top 2000 variable features (nfeature argument) training. training, retains 50 genes per SE (nfeature.per.se argument) model. Users can tune parameters accordingly. resulting W matrix can used infer SE abundances bulk gene expression profiles using DeconvoluteSE function. detailed documentation SE deconvolution available Recovery Spatial Ecotypes Bulk Gene Expression Data.","code":"W = NMFGenerateW(result$Fracs, result$Mixtures) ## This step took less than 1 min for the demo. head(W) ##                       nonSE          SE1          SE2          SE3          SE4 ## IGLV1-40__pos  6.435004e-02 2.220446e-16 2.220446e-16 2.220446e-16 2.220446e-16 ## IGHV4-34__pos  2.220446e-16 2.220446e-16 1.352908e-07 1.027098e-12 2.220446e-16 ## IGLV2-14__pos  4.468224e+00 2.220446e-16 1.323646e-15 2.220446e-16 1.962789e-01 ## IGKV2D-30__pos 1.061495e-15 2.220446e-16 6.075700e-01 1.292995e-15 1.082039e-15 ## IGKV1-33__pos  2.220446e-16 2.220446e-16 1.326303e-08 2.206336e-12 2.220446e-16 ## NLRP3__pos     2.220446e-16 2.220446e-16 2.220446e-16 2.220446e-16 2.220446e-16 ##                         SE5          SE6          SE7          SE8          SE9 ## IGLV1-40__pos  1.003067e-06 2.220446e-16 4.618030e+00 9.300405e-10 2.220446e-16 ## IGHV4-34__pos  1.264496e-11 2.220446e-16 4.671389e+00 2.220446e-16 2.220446e-16 ## IGLV2-14__pos  2.220446e-16 2.220446e-16 2.220446e-16 5.860832e-09 2.220446e-16 ## IGKV2D-30__pos 2.220446e-16 2.220446e-16 4.054420e+00 2.220446e-16 4.717884e-13 ## IGKV1-33__pos  2.841738e-12 2.220446e-16 4.649631e+00 2.220446e-16 3.816478e-16 ## NLRP3__pos     2.220446e-16 4.617904e+00 2.220446e-16 2.220446e-16 2.220446e-16 ## Save the model for late use. saveRDS(W, \"SE_Deconvolution_W.rds\")"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/TrainRecoveryModels.html","id":"session-info","dir":"Articles","previous_headings":"","what":"Session info","title":"Development of NMF Models for Spatial Ecotype Recovery","text":"session info allows users replicate exact environment identify potential discrepancies package versions configurations might causing problems.","code":"sessionInfo() ## R version 4.4.1 (2024-06-14) ## Platform: aarch64-apple-darwin20 ## Running under: macOS 15.1 ##  ## Matrix products: default ## BLAS:   /Library/Frameworks/R.framework/Versions/4.4-arm64/Resources/lib/libRblas.0.dylib  ## LAPACK: /Library/Frameworks/R.framework/Versions/4.4-arm64/Resources/lib/libRlapack.dylib;  LAPACK version 3.12.0 ##  ## locale: ## [1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8 ##  ## time zone: America/Los_Angeles ## tzcode source: internal ##  ## attached base packages: ## [1] parallel  stats     graphics  grDevices utils     datasets  methods   ## [8] base      ##  ## other attached packages: ##  [1] SpatialEcoTyper_1.0.0 RANN_2.6.2            Matrix_1.7-0          ##  [4] dplyr_1.1.4           data.table_1.16.0     NMF_0.28              ##  [7] Biobase_2.64.0        BiocGenerics_0.50.0   cluster_2.1.6         ## [10] rngtools_1.5.2        registry_0.5-1        Seurat_5.1.0          ## [13] SeuratObject_5.0.2    sp_2.1-4              googledrive_2.1.1     ##  ## loaded via a namespace (and not attached): ##   [1] RColorBrewer_1.1-3     shape_1.4.6.1          rstudioapi_0.16.0      ##   [4] jsonlite_1.8.8         magrittr_2.0.3         spatstat.utils_3.1-0   ##   [7] rmarkdown_2.28         GlobalOptions_0.1.2    fs_1.6.4               ##  [10] ragg_1.3.2             vctrs_0.6.5            ROCR_1.0-11            ##  [13] spatstat.explore_3.3-2 htmltools_0.5.8.1      curl_5.2.2             ##  [16] sass_0.4.9             sctransform_0.4.1      parallelly_1.38.0      ##  [19] KernSmooth_2.23-24     bslib_0.8.0            htmlwidgets_1.6.4      ##  [22] desc_1.4.3             ica_1.0-3              plyr_1.8.9             ##  [25] plotly_4.10.4          zoo_1.8-12             cachem_1.1.0           ##  [28] igraph_2.0.3           iterators_1.0.14       mime_0.12              ##  [31] lifecycle_1.0.4        pkgconfig_2.0.3        R6_2.5.1               ##  [34] fastmap_1.2.0          clue_0.3-65            fitdistrplus_1.2-1     ##  [37] future_1.34.0          shiny_1.9.1            digest_0.6.37          ##  [40] colorspace_2.1-1       S4Vectors_0.42.1       patchwork_1.2.0        ##  [43] tensor_1.5             RSpectra_0.16-2        irlba_2.3.5.1          ##  [46] textshaping_0.4.0      progressr_0.14.0       fansi_1.0.6            ##  [49] spatstat.sparse_3.1-0  httr_1.4.7             polyclip_1.10-7        ##  [52] abind_1.4-5            compiler_4.4.1         gargle_1.5.2           ##  [55] withr_3.0.1            doParallel_1.0.17      fastDummies_1.7.4      ##  [58] R.utils_2.12.3         MASS_7.3-60.2          rjson_0.2.22           ##  [61] tools_4.4.1            lmtest_0.9-40          httpuv_1.6.15          ##  [64] future.apply_1.11.2    goftest_1.2-3          R.oo_1.26.0            ##  [67] glue_1.7.0             nlme_3.1-164           promises_1.3.0         ##  [70] grid_4.4.1             gridBase_0.4-7         Rtsne_0.17             ##  [73] reshape2_1.4.4         generics_0.1.3         gtable_0.3.5           ##  [76] spatstat.data_3.1-2    R.methodsS3_1.8.2      tidyr_1.3.1            ##  [79] utf8_1.2.4             spatstat.geom_3.3-2    RcppAnnoy_0.0.22       ##  [82] foreach_1.5.2          ggrepel_0.9.6          pillar_1.9.0           ##  [85] stringr_1.5.1          spam_2.10-0            RcppHNSW_0.6.0         ##  [88] later_1.3.2            circlize_0.4.16        splines_4.4.1          ##  [91] lattice_0.22-6         survival_3.6-4         deldir_2.0-4           ##  [94] tidyselect_1.2.1       ComplexHeatmap_2.20.0  miniUI_0.1.1.1         ##  [97] pbapply_1.7-2          knitr_1.48             gridExtra_2.3          ## [100] IRanges_2.38.1         scattermore_1.2        stats4_4.4.1           ## [103] xfun_0.47              matrixStats_1.4.1      stringi_1.8.4          ## [106] lazyeval_0.2.2         yaml_2.3.10            evaluate_0.24.0        ## [109] codetools_0.2-20       tibble_3.2.1           BiocManager_1.30.25    ## [112] cli_3.6.3              uwot_0.2.2             xtable_1.8-4           ## [115] reticulate_1.39.0      systemfonts_1.1.0      munsell_0.5.1          ## [118] jquerylib_0.1.4        Rcpp_1.0.13            globals_0.16.3         ## [121] spatstat.random_3.3-1  png_0.1-8              spatstat.univar_3.0-1  ## [124] pkgdown_2.1.0          ggplot2_3.5.1          dotCall64_1.1-1        ## [127] listenv_0.9.1          viridisLite_0.4.2      scales_1.3.0           ## [130] ggridges_0.5.6         crayon_1.5.3           leiden_0.4.3.1         ## [133] purrr_1.0.2            GetoptLong_1.0.5       rlang_1.1.4            ## [136] cowplot_1.1.3"},{"path":"https://digitalcytometry.github.io/spatialecotyper/authors.html","id":null,"dir":"","previous_headings":"","what":"Authors","title":"Authors and Citation","text":"Wubing Zhang. Author, maintainer.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/authors.html","id":"citation","dir":"","previous_headings":"","what":"Citation","title":"Authors and Citation","text":"Zhang W (2024). SpatialEcoTyper: Spatial ecotype analaysis. R package version 1.0.0, https://digitalcytometry.github/spatialecotyper.","code":"@Manual{,   title = {SpatialEcoTyper: Spatial ecotype analaysis},   author = {Wubing Zhang},   year = {2024},   note = {R package version 1.0.0},   url = {https://digitalcytometry.github/spatialecotyper}, }"},{"path":"https://digitalcytometry.github.io/spatialecotyper/index.html","id":"deciphering-spatial-ecotypes-from-spatial-single-cell-and-bulk-transcriptomic-data","dir":"","previous_headings":"","what":"Spatial ecotype analaysis","title":"Spatial ecotype analaysis","text":"Spatial EcoTyper versatile framework designed systematic identification spatial cellular communities, termed spatial ecotypes, single-cell spatial transcriptomics data. addition, provides unified methods recovery spatial ecotypes across multiple data modalities, including spatial transcriptomics, single-cell RNA-seq, bulk transcriptomic datasets.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/index.html","id":"overview-of-spatial-ecotyper","dir":"","previous_headings":"","what":"Overview of Spatial EcoTyper","title":"Spatial ecotype analaysis","text":"Spatial EcoTyper available R package, comprehensive documentation accessible https://digitalcytometry.github.io/spatialecotyper. Additionally, Spatial EcoTyper can used via web platform https://spatialecotyper.stanford.edu/ (available soon), user-friendly interface recovering spatial ecotypes various data sources, including spatial transcriptomics (e.g. MERSCOPE, Visium, etc), single-cell RNA-seq, bulk gene expression datasets. provide 6 comprehensive tutorials illustrating functionalities included SpatialEcoTyper R package. first tutorial demonstrates identify spatial ecotypes single-cell spatial transcriptomics data. second demonstrates identified conserved spatial ecotypes across multiple samples. third demonstrates develop NMF models recovery spatial ecotypes unseen data. remaining tutorials introduce recover spatial ecotypes spatial transcriptomics, scRNA-seq, bulk RNA-seq datasets. Tutorial 1: Discovery Spatial Ecotypes Single Sample Tutorial 2: Discovery Spatial Ecotypes Multiple Samples Tutorial 3: Development NMF Models Spatial Ecotype Recovery Tutorial 4: Recovery Spatial Ecotypes Spatial Transcriptomics Data Tutorial 5: Recovery Spatial Ecotypes Single-Cell Gene Expression Data Tutorial 6: Recovery Spatial Ecotypes Bulk Gene Expression Data Note: Spatial EcoTyper depends extensively Seurat key processes like dimensionality reduction, UMAP embedding, clustering, visualization. Initially developed using Seurat v4.3, tool thoroughly tested validated Seurat v5. Although UMAP embeddings clustering results show slight differences Seurat v4 v5, overall consistency remains strong, ensuring core biological insights preserved across versions.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/index.html","id":"installation","dir":"","previous_headings":"","what":"Installation","title":"Spatial ecotype analaysis","text":"Spatial EcoTyper available R package can installed via BiocManager package directly R console. ERROR: dependency ‘GetoptLong’ available package ‘ComplexHeatmap’ installation within R console fails, can try installing necessary packages via conda install mamba install. Failed install ‘presto’ GitHub: HTTP error 401. Bad credentials resolve issue, ’ll need authenticate using personal access token (PAT). can generate GitHub personal access token following GitHub’s documentation. generating token, set environment variable R using following code. Replace “YOUR_TOKEN” actual token: source code Spatial EcoTyper available https://github.com/digitalcytometry/spatialecotyper. downloading package, can install source code using command:","code":"if(!\"BiocManager\" %in% installed.packages()){   install.packages(\"BiocManager\") }  ## Install dependencies BiocManager::install(c(\"remotes\", \"Seurat\", \"NMF\", \"dplyr\", \"pals\",                        \"data.table\", \"ComplexHeatmap\", \"googledrive\",                         \"glmGamPoi\", \"immunogenomics/presto\"))  ## Install SpatialEcoTyper BiocManager::install(\"digitalcytometry/spatialecotyper\") conda install bioconda::bioconductor-complexheatmap ## Set the token in your R environment: Sys.setenv(GITHUB_PAT=\"YOUR_TOKEN\")  ## Install the package from GitHub: BiocManager::install(\"immunogenomics/presto\") install.packages(\"SpatialEcoTyper.tar.gz\", repos = NULL)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/index.html","id":"contribution","dir":"","previous_headings":"","what":"Contribution","title":"Spatial ecotype analaysis","text":"encounter bugs suggestions improvements, please feel free open issue submit pull request. feedback contributions help us make tool better everyone.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/index.html","id":"license","dir":"","previous_headings":"","what":"License","title":"Spatial ecotype analaysis","text":"Please see LICENSE file.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/index.html","id":"authors","dir":"","previous_headings":"","what":"Authors","title":"Spatial ecotype analaysis","text":"Spatial EcoTyper developed Newman Lab Wubing Zhang.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/index.html","id":"citation","dir":"","previous_headings":"","what":"Citation","title":"Spatial ecotype analaysis","text":"use Spatial EcoTyper, please cite:","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/AnnotateCells.html","id":null,"dir":"Reference","previous_headings":"","what":"Extract Spatial Ecotype Annotations for Single Cells — AnnotateCells","title":"Extract Spatial Ecotype Annotations for Single Cells — AnnotateCells","text":"function adds spatial ecotype annotations metadata single cells.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/AnnotateCells.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Extract Spatial Ecotype Annotations for Single Cells — AnnotateCells","text":"","code":"AnnotateCells(scmeta, obj)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/AnnotateCells.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Extract Spatial Ecotype Annotations for Single Cells — AnnotateCells","text":"scmeta Data frame containing single-cell metadata. Two columns (X Y) spatial coordinates required. obj Seurat object returned SpatialEcoTyper function.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/AnnotateCells.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Extract Spatial Ecotype Annotations for Single Cells — AnnotateCells","text":"modified version `scmeta` spatial ecotype annotations added.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/AnnotateCells.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Extract Spatial Ecotype Annotations for Single Cells — AnnotateCells","text":"","code":"library(data.table) #>  #> Attaching package: ‘data.table’ #> The following objects are masked from ‘package:dplyr’: #>  #>     between, first, last library(Seurat) library(SpatialEcoTyper) library(googledrive) drive_deauth() # no Google sign-in is required ## Download a single-cell meta data drive_download(as_id(\"1CgUOQKrWY_TG61o5aw7J9LZzE20D6NuI\"),                     \"HumanMelanomaPatient1_subset_scmeta.tsv\",                      overwrite = TRUE) #> File downloaded: #> • HumanMelanomaPatient1_subset_scmeta.tsv #>    #> Saved locally as: #> • HumanMelanomaPatient1_subset_scmeta.tsv ## Obtain a Seurat object from SpatialEcoTyper result drive_download(as_id(\"1nSPj2zRywFUdbo1fwiz77ds4NuM6bmV2\"),               \"Melanoma1_subset_SpatialEcoTyper_results.rds\", overwrite = TRUE) #> Error in map(as_id(id), get_one_file_id): ℹ In index: 1. #> Caused by error in `.f()`: #> ! Client error: (404) Not Found #> File not found: 1nSPj2zRywFUdbo1fwiz77ds4NuM6bmV2. #> • message: File not found: 1nSPj2zRywFUdbo1fwiz77ds4NuM6bmV2. #> • domain: global #> • reason: notFound #> • location: fileId #> • locationType: parameter  scmeta <- read.table(\"HumanMelanomaPatient1_subset_scmeta.tsv\",                      sep = \"\\t\", header = TRUE, row.names = 1) head(scmeta) #>                                         X         Y   CellType CellTypeName #> HumanMelanomaPatient1__cell_3655 1894.706 -6367.766 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3657 1942.480 -6369.602 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3658 1963.007 -6374.026 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3660 1981.600 -6372.266 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3661 1742.939 -6374.851 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3663 1921.683 -6383.309 Fibroblast  Fibroblasts #>                                  Region Dist2Interface #> HumanMelanomaPatient1__cell_3655 Stroma      -883.1752 #> HumanMelanomaPatient1__cell_3657 Stroma      -894.8463 #> HumanMelanomaPatient1__cell_3658 Stroma      -904.1115 #> HumanMelanomaPatient1__cell_3660 Stroma      -907.8909 #> HumanMelanomaPatient1__cell_3661 Stroma      -874.2712 #> HumanMelanomaPatient1__cell_3663 Stroma      -903.6559 obj <- readRDS(\"Melanoma1_subset_SpatialEcoTyper_results.rds\")$obj #> Warning: cannot open compressed file 'Melanoma1_subset_SpatialEcoTyper_results.rds', probable reason 'No such file or directory' #> Error in gzfile(file, \"rb\"): cannot open the connection  ## Transfer SE annotations to single cells scmeta <- AnnotateCells(scmeta = scmeta, obj = obj) #> Error in eval(expr, envir, enclos): object 'obj' not found head(scmeta) #>                                         X         Y   CellType CellTypeName #> HumanMelanomaPatient1__cell_3655 1894.706 -6367.766 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3657 1942.480 -6369.602 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3658 1963.007 -6374.026 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3660 1981.600 -6372.266 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3661 1742.939 -6374.851 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3663 1921.683 -6383.309 Fibroblast  Fibroblasts #>                                  Region Dist2Interface #> HumanMelanomaPatient1__cell_3655 Stroma      -883.1752 #> HumanMelanomaPatient1__cell_3657 Stroma      -894.8463 #> HumanMelanomaPatient1__cell_3658 Stroma      -904.1115 #> HumanMelanomaPatient1__cell_3660 Stroma      -907.8909 #> HumanMelanomaPatient1__cell_3661 Stroma      -874.2712 #> HumanMelanomaPatient1__cell_3663 Stroma      -903.6559"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/ComputeAvg.html","id":null,"dir":"Reference","previous_headings":"","what":"Compute Cell-Type-Specific Average Expression of Spatial Clusters — ComputeAvg","title":"Compute Cell-Type-Specific Average Expression of Spatial Clusters — ComputeAvg","text":"Compute Cell-Type-Specific Average Expression Spatial Clusters","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/ComputeAvg.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Compute Cell-Type-Specific Average Expression of Spatial Clusters — ComputeAvg","text":"","code":"ComputeAvg(   normdata,   scmeta,   cluster = \"SE\",   Region = NULL,   scale = TRUE,   ncores = 4 )"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/ComputeAvg.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Compute Cell-Type-Specific Average Expression of Spatial Clusters — ComputeAvg","text":"normdata Numeric matrix normalized expression data, rows represent genes columns represent cells. scmeta Data frame containing metadata associated cell, including spatial cluster cell type annotations. cluster Character string specifying column name 'scmeta' containing spatial cluster annotations. Region Character string specifying column name metadata data frames containing region annotations (default: NULL). scale boolean specifying whether univariance normalization. ncores Integer specifying number CPU cores use parallel processing.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/ComputeAvg.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Compute Cell-Type-Specific Average Expression of Spatial Clusters — ComputeAvg","text":"matrix average expression, rows represent genes columns represent spatial clusters sample.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/ComputeAvg.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Compute Cell-Type-Specific Average Expression of Spatial Clusters — ComputeAvg","text":"","code":"library(data.table) library(Seurat) library(SpatialEcoTyper) library(googledrive) drive_deauth() # no Google sign-in is required drive_download(as_id(\"13Rc5Rsu8jbnEYYfUse-xQ7ges51LcI7n\"),                     \"HumanMelanomaPatient1_subset_counts.tsv.gz\",                     overwrite = TRUE, verbose = FALSE) drive_download(as_id(\"1GUbbEBttiu2ntVpaIcIK7YobaKKwbqnM\"),                     \"HumanMelanomaPatient1_subset_SpatialEcoTyper_results.rds\",                     overwrite = TRUE, verbose = FALSE) scdata <- fread(\"HumanMelanomaPatient1_subset_counts.tsv.gz\",                 sep = \"\\t\",header = TRUE, data.table = FALSE) rownames(scdata) <- scdata[, 1] scdata <- as.matrix(scdata[, -1]) tmpobj <- CreateSeuratObject(scdata) %>%         SCTransform(clip.range = c(-10, 10), verbose = FALSE) seurat_version = as.integer(gsub(\"\\\\..*\", \"\", as.character(packageVersion(\"Seurat\")))) if(seurat_version<5){   normdata <- GetAssayData(tmpobj, \"data\") }else{   normdata <- tmpobj[[\"SCT\"]]$data } metadata = readRDS(\"HumanMelanomaPatient1_subset_SpatialEcoTyper_results.rds\")$metadata  # Construct cell-type-specific gene expression signatures of SEs avgexprs <- ComputeAvg(normdata = normdata, scmeta = metadata) head(avgexprs) #>                             SE09        SE01        SE08         SE07 #> Fibroblast..PDK4      0.35259620  0.13410953  0.06966571  0.118335435 #> Fibroblast..TNFRSF17  0.00000000  0.00000000  0.00000000  0.000000000 #> Fibroblast..ICAM3     0.00000000  0.00000000  0.00000000  0.000000000 #> Fibroblast..FAP      -0.29331695  0.02505667 -0.07346211  0.077473474 #> Fibroblast..GZMB     -0.09797678 -0.04104210 -0.09082236 -0.002063296 #> Fibroblast..TSC2     -0.05899541 -0.02658523 -0.02690466 -0.016824868 #>                             SE04        SE03         SE06       SE02       SE05 #> Fibroblast..PDK4     -0.04187951 -0.18236328 -0.121186218 0.02876511 0.01315714 #> Fibroblast..TNFRSF17  0.00000000  0.00000000  0.000000000 0.00000000 0.00000000 #> Fibroblast..ICAM3     0.00000000  0.00000000  0.000000000 0.00000000 0.00000000 #> Fibroblast..FAP       0.05147663 -0.08659207  0.053183806 0.02960319 0.11607862 #> Fibroblast..GZMB      0.01127651  0.02282926 -0.009071706 0.03888278 0.04906746 #> Fibroblast..TSC2      0.02419604 -0.04820711 -0.001317502 0.07683963 0.09783272"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/ComputeAvgs.html","id":null,"dir":"Reference","previous_headings":"","what":"Compute Cell-Type-Specific Average Expression of Spatial Clusters — ComputeAvgs","title":"Compute Cell-Type-Specific Average Expression of Spatial Clusters — ComputeAvgs","text":"Compute Cell-Type-Specific Average Expression Spatial Clusters","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/ComputeAvgs.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Compute Cell-Type-Specific Average Expression of Spatial Clusters — ComputeAvgs","text":"","code":"ComputeAvgs(   normdata,   scmeta,   cluster = \"SE\",   Region = NULL,   scale = TRUE,   ncores = 4 )"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/ComputeAvgs.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Compute Cell-Type-Specific Average Expression of Spatial Clusters — ComputeAvgs","text":"normdata Numeric matrix normalized expression data, rows represent genes columns represent cells. scmeta Data frame containing metadata associated cell, including spatial cluster cell type annotations. cluster Character string specifying column name 'scmeta' containing spatial cluster annotations. Region Character string specifying column name metadata data frames containing region annotations (default: NULL). scale boolean specifying whether univariance normalization. ncores Integer specifying number CPU cores use parallel processing.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/ComputeAvgs.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Compute Cell-Type-Specific Average Expression of Spatial Clusters — ComputeAvgs","text":"matrix average expression, rows represent genes columns represent spatial clusters sample.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/ComputeAvgs.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Compute Cell-Type-Specific Average Expression of Spatial Clusters — ComputeAvgs","text":"","code":"library(data.table) library(Seurat) library(SpatialEcoTyper) library(googledrive) drive_deauth() # no Google sign-in is required drive_download(as_id(\"1CoQmU3u8MoVC8RbLUvTDQmOuJJ703HHB\"),               \"HumanMelanomaPatient1_subset_counts.tsv.gz\", overwrite = TRUE) #> File downloaded: #> • HumanMelanomaPatient1_subset_counts.tsv.gz #>    #> Saved locally as: #> • HumanMelanomaPatient1_subset_counts.tsv.gz drive_download(as_id(\"1nSPj2zRywFUdbo1fwiz77ds4NuM6bmV2\"),               \"Melanoma1_subset_SpatialEcoTyper_results.rds\", overwrite = TRUE) #> Error in map(as_id(id), get_one_file_id): ℹ In index: 1. #> Caused by error in `.f()`: #> ! Client error: (404) Not Found #> File not found: 1nSPj2zRywFUdbo1fwiz77ds4NuM6bmV2. #> • message: File not found: 1nSPj2zRywFUdbo1fwiz77ds4NuM6bmV2. #> • domain: global #> • reason: notFound #> • location: fileId #> • locationType: parameter scdata <- fread(\"HumanMelanomaPatient1_subset_counts.tsv.gz\",                 sep = \"\\t\",header = TRUE, data.table = FALSE) rownames(scdata) <- scdata[, 1] scdata <- as.matrix(scdata[, -1]) tmpobj <- CreateSeuratObject(scdata) %>%         SCTransform(clip.range = c(-10, 10), verbose = FALSE) #> Warning: Data is of class matrix. Coercing to dgCMatrix. seurat_version = as.integer(gsub(\"\\\\..*\", \"\", as.character(packageVersion(\"SeuratObject\")))) if(seurat_version<5){   normdata <- GetAssayData(tmpobj, \"data\") }else{   normdata <- tmpobj[[\"SCT\"]]$data } metadata = readRDS(\"Melanoma1_subset_SpatialEcoTyper_results.rds\")$metadata #> Warning: cannot open compressed file 'Melanoma1_subset_SpatialEcoTyper_results.rds', probable reason 'No such file or directory' #> Error in gzfile(file, \"rb\"): cannot open the connection  # Construct cell-type-specific gene expression signatures of SEs avgexprs <- ComputeAvgs(normdata = normdata, scmeta = metadata) #> Error in eval(expr, envir, enclos): object 'metadata' not found head(avgexprs) #> Error in h(simpleError(msg, call)): error in evaluating the argument 'x' in selecting a method for function 'head': object 'avgexprs' not found"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/ComputeFCs.html","id":null,"dir":"Reference","previous_headings":"","what":"Compute Cell-Type-Specific Fold Changes (FCs) for Spatial Clusters — ComputeFCs","title":"Compute Cell-Type-Specific Fold Changes (FCs) for Spatial Clusters — ComputeFCs","text":"function computes fold changes (FCs) spatial transcriptomic data, comparing expression levels spatial clusters within cell type.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/ComputeFCs.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Compute Cell-Type-Specific Fold Changes (FCs) for Spatial Clusters — ComputeFCs","text":"","code":"ComputeFCs(   normdata,   scmeta,   cluster = \"SE\",   Region = NULL,   scale = FALSE,   ncores = parallel::detectCores() )"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/ComputeFCs.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Compute Cell-Type-Specific Fold Changes (FCs) for Spatial Clusters — ComputeFCs","text":"normdata Numeric matrix normalized expression data, rows represent genes columns represent cells. scmeta Data frame containing metadata associated cell, including spatial cluster cell type annotations. cluster Character string specifying column name 'scmeta' containing spatial cluster annotations. Region Character string specifying column name metadata data frames containing region annotations (default: NULL). scale boolean specifying whether univariance normalization. ncores Integer specifying number CPU cores use parallel processing.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/ComputeFCs.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Compute Cell-Type-Specific Fold Changes (FCs) for Spatial Clusters — ComputeFCs","text":"matrix fold changes (FCs), rows represent genes columns represent spatial clusters sample.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/CreatePseudobulks.html","id":null,"dir":"Reference","previous_headings":"","what":"Create Pseudo-bulk Mixtures — CreatePseudobulks","title":"Create Pseudo-bulk Mixtures — CreatePseudobulks","text":"function generates pseudobulk samples aggregating single-cell transcriptomics.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/CreatePseudobulks.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Create Pseudo-bulk Mixtures — CreatePseudobulks","text":"","code":"CreatePseudobulks(data = NULL, groups, counts = NULL, n_mixtures = 100)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/CreatePseudobulks.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Create Pseudo-bulk Mixtures — CreatePseudobulks","text":"data matrix normalized gene expression data (genes x cells). NULL, counts must provided. groups named vector indicating group (e.g., spatial ecotype) cell. names correspond column names data matrix. counts matrix raw counts data (genes x cells). Used generate normalized data data provided. n_mixtures integer specifying number pseudobulk samples create. Default 100.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/CreatePseudobulks.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Create Pseudo-bulk Mixtures — CreatePseudobulks","text":"list containing two elements: Fracs matrix fractions group pseudobulk samples (rows represent pseudobulk samples, columns represent groups). Mixtures matrix pseudobulk gene expression data (genes x pseudobulk samples).","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/CreatePseudobulks.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Create Pseudo-bulk Mixtures — CreatePseudobulks","text":"`data` provided, function normalize `counts` matrix dividing column sum multiplying 10,000. maximum value `data` less 80, assumes data log2 scale converts back non-log scale. `groups` vector used ensure cells correctly assigned respective groups.   `groups` names, assumed names correspond column names `data` matrix. Pseudobulk samples created sampling cells group based predefined fractions,   calculating average expression gene pseudobulk samples. pseudobulk data normalized using Seurat's `NormalizeData` function.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/CreatePseudobulks.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Create Pseudo-bulk Mixtures — CreatePseudobulks","text":"","code":"library(SpatialEcoTyper) library(googledrive) drive_deauth() # no Google sign-in is required drive_download(as_id(\"15n9zlXed74oeGaO1pythOOM_iWIfuMn2\"), \"Melanoma_WU2161_counts.rds\",                     overwrite = TRUE) #> File downloaded: #> • Melanoma_WU2161_counts.rds  #> Saved locally as: #> • Melanoma_WU2161_counts.rds counts <- readRDS(\"Melanoma_WU2161_counts.rds\") ## raw counts of scRNA-seq data groups <- sample(paste0(\"SE\", 1:10), ncol(counts), replace = TRUE) names(groups) <- colnames(counts) result = CreatePseudobulks(counts = counts, groups = groups, n_mixtures = 20) head(result$Mixtures[, 1:5]) ## Gene expression matrix of pseudobulks #>            Pseudobulk1 Pseudobulk2  Pseudobulk3  Pseudobulk4  Pseudobulk5 #> AL627309.1 0.010074937 0.026466048 0.0171018497 0.0171069227 0.0255710058 #> AL627309.5 0.028185407 0.028121530 0.0440359686 0.0470177161 0.0566584344 #> AP006222.2 0.005813013 0.002907824 0.0051710095 0.0088178291 0.0068326888 #> AC114498.1 0.014872736 0.014857974 0.0069979292 0.0069840099 0.0069909626 #> AL669831.2 0.001482140 0.000000000 0.0003703704 0.0007391259 0.0003700004 #> LINC01409  0.038924808 0.030773482 0.0406855932 0.0485869241 0.0419149703 head(result$Fracs) ## SE fractions in pseudobulks #>                     SE1       SE10        SE2        SE3        SE4        SE5 #> Pseudobulk1 0.148299599 0.04084198 0.13605238 0.04812145 0.07334537 0.16468016 #> Pseudobulk2 0.180245105 0.03591520 0.03277197 0.16672719 0.17952414 0.11634038 #> Pseudobulk3 0.078572940 0.08653050 0.12737995 0.10409351 0.08368176 0.06809299 #> Pseudobulk4 0.073579654 0.20107738 0.10550911 0.11484678 0.07561444 0.11455294 #> Pseudobulk5 0.003943657 0.15120503 0.09552227 0.05698550 0.14124883 0.10354736 #> Pseudobulk6 0.067123736 0.11070905 0.15959928 0.07370885 0.15368544 0.06388965 #>                    SE6        SE7        SE8        SE9 #> Pseudobulk1 0.00000000 0.16123196 0.02122383 0.20620327 #> Pseudobulk2 0.03504460 0.11745721 0.00000000 0.13597421 #> Pseudobulk3 0.16320454 0.09041136 0.07594698 0.12208546 #> Pseudobulk4 0.04802129 0.16669192 0.05996442 0.04014206 #> Pseudobulk5 0.07907159 0.13299510 0.08381708 0.15166359 #> Pseudobulk6 0.16595165 0.01566788 0.13811904 0.05154544"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/DeconvoluteSE.html","id":null,"dir":"Reference","previous_headings":"","what":"Infer SE Abundances Using Pretrained NMF Model — DeconvoluteSE","title":"Infer SE Abundances Using Pretrained NMF Model — DeconvoluteSE","text":"function predicts SE abundances mixture.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/DeconvoluteSE.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Infer SE Abundances Using Pretrained NMF Model — DeconvoluteSE","text":"","code":"DeconvoluteSE(dat, scale = TRUE, W = NULL)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/DeconvoluteSE.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Infer SE Abundances Using Pretrained NMF Model — DeconvoluteSE","text":"dat numeric matrix bulk gene expression data. scale Logical indicating whether scale input data predictions. W W matrix inferring SE abundances bulk expression data.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/DeconvoluteSE.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Infer SE Abundances Using Pretrained NMF Model — DeconvoluteSE","text":"matrix SE abundances bulk tumors.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/DeconvoluteSE.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Infer SE Abundances Using Pretrained NMF Model — DeconvoluteSE","text":"","code":"library(googledrive) drive_deauth() # no Google sign-in is required drive_download(as_id(\"14QvmgISxaArTzWt_UHvf55aAYN2zm84Q\"), \"SKCM_RNASeqV2.geneExp.rds\",                     overwrite = TRUE) #> File downloaded: #> • SKCM_RNASeqV2.geneExp.rds  #> Saved locally as: #> • SKCM_RNASeqV2.geneExp.rds bulkdata <- readRDS(\"SKCM_RNASeqV2.geneExp.rds\")  # Predict SE abundances in bulk tumors se_abundances <- DeconvoluteSE(dat = bulkdata) head(se_abundances[, 1:5]) #>                      nonSE        SE1        SE2        SE3        SE4 #> TCGA-3N-A9WB-06 0.19380234 0.05372667 0.16735600 0.12581663 0.07216666 #> TCGA-3N-A9WC-06 0.05293689 0.13901340 0.08427617 0.08372047 0.04243859 #> TCGA-3N-A9WD-06 0.27200075 0.17114795 0.06288761 0.05641549 0.10166721 #> TCGA-BF-A1PU-01 0.16899510 0.13618971 0.06501306 0.09269615 0.17313296 #> TCGA-BF-A1PV-01 0.12078283 0.06921834 0.05970319 0.16813008 0.11059648 #> TCGA-BF-A1PX-01 0.21398415 0.04019509 0.08906215 0.04499893 0.08561680"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/GetPCList.html","id":null,"dir":"Reference","previous_headings":"","what":"Generate Principal Component (PC) List for Spatial Microregions — GetPCList","title":"Generate Principal Component (PC) List for Spatial Microregions — GetPCList","text":"function performs principal component analysis based cell-type-specific gene expression spatial microregions.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/GetPCList.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Generate Principal Component (PC) List for Spatial Microregions — GetPCList","text":"","code":"GetPCList(   mergedncem,   min.cells = 3,   min.features = 5,   nfeatures = 3000,   ncores = 1,   do.scale = TRUE )"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/GetPCList.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Generate Principal Component (PC) List for Spatial Microregions — GetPCList","text":"mergedncem matrix cell-type-specific gene expression data, rows representing genes columns representing spatial microregions cell type. min.cells Integer, minimum number non-zero counts required per gene retain gene analysis. Default 3. min.features Integer, minimum number features (genes) required per spatial microregion retain microregion analysis. Default 5. nfeatures Integer, number variable features select PCA. Default 3000. ncores Integer, number cores use parallel processing. Default 1. .scale Logical, whether scale data performing PCA. Default TRUE.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/GetPCList.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Generate Principal Component (PC) List for Spatial Microregions — GetPCList","text":"named list matrices, matrix contains PCs specific cell type. Cell types insufficient data excluded result.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/GetPCList.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Generate Principal Component (PC) List for Spatial Microregions — GetPCList","text":"function first filters input matrix based specified minimum number cells features. creates Seurat objects cell type, normalizes data, identifies variable features, scales data, performs PCA. resulting PCs cell type returned list.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/GetSNlist.html","id":null,"dir":"Reference","previous_headings":"","what":"Construct Cell-Type-Specific Similarity Network — GetSNList","title":"Construct Cell-Type-Specific Similarity Network — GetSNList","text":"function generates list similarity networks (SNs) given list embeddings. embeddings represent spatial microregions, function computes K-nearest neighbor (KNN) graphs based provided embeddings create similarity matrices.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/GetSNlist.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Construct Cell-Type-Specific Similarity Network — GetSNList","text":"","code":"GetSNList(emb_list, npcs = 20, k = 50, min.cts.per.region = 1, ncores = 1)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/GetSNlist.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Construct Cell-Type-Specific Similarity Network — GetSNList","text":"emb_list list matrices matrix contains embeddings single sample. rows correspond different principal components (PCs) features, columns correspond spatial regions cells. npcs integer specifying number principal components features use embedding matrix. Default 20. k integer specifying number nearest neighbors consider constructing KNN graph. Default 50. min.cts.per.region integer specifying minimum number distinct cell types must present spatial region retained analysis. Default 1. ncores integer specifying number cores use parallel computation. Default 1.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/GetSNlist.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Construct Cell-Type-Specific Similarity Network — GetSNList","text":"list sparse matrices matrix represents similarity network (SN) sample. rows columns matrix correspond spatial regions, values represent similarity scores.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/GetSNlist.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Construct Cell-Type-Specific Similarity Network — GetSNList","text":"function first trims input embeddings retain top `npcs` principal components features. filters spatial regions meet minimum cell type threshold. sample, function computes KNN graph using trimmed embeddings converts resulting distances similarity scores. Missing spatial regions filled zeros ensure samples regions.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/GetSpatialMetacells.html","id":null,"dir":"Reference","previous_headings":"","what":"Construct Spatial Metacells from Single-Cell Spatial Data — GetSpatialMetacells","title":"Construct Spatial Metacells from Single-Cell Spatial Data — GetSpatialMetacells","text":"function computes spatial metacells single-cell spatial transcriptomics. Spatial metacells represent aggregated expression profiles spatially proximal cells. function utilizes k-nearest neighbor (KNN) weighting aggregate expression profiles neighboring cells generate metacell expression profiles cell type.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/GetSpatialMetacells.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Construct Spatial Metacells from Single-Cell Spatial Data — GetSpatialMetacells","text":"","code":"GetSpatialMetacells(   normdata,   metadata,   X = \"X\",   Y = \"Y\",   CellType = \"CellType\",   k = 20,   radius = 50,   bin = \"SpotID\",   bin.X = \"Spot.X\",   bin.Y = \"Spot.Y\",   min.cells.per.region = 1,   ncores = 1 )"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/GetSpatialMetacells.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Construct Spatial Metacells from Single-Cell Spatial Data — GetSpatialMetacells","text":"normdata matrix data frame representing normalized gene expression data, rows correspond genes columns correspond cells. metadata data frame containing metadata associated cell. Must include spatial coordinates (e.g., X Y) well cell type annotations. row names metadata must match column names normdata. X Character string specifying column name metadata containing X spatial coordinates. Y Character string specifying column name metadata containing Y spatial coordinates. CellType Character string specifying column name metadata containing cell type annotations. k Integer specifying number nearest spatial neighbors constructing metacells. radius Numeric value specifying radius (units spatial coordinates) within neighboring cells considered. bin Character string specifying column name metadata containing microregion identifier. bin.X Character string specifying column name metadata containing X spatial coordinates microregions. bin.Y Character string specifying column name metadata containing Y spatial coordinates microregions. min.cells.per.region Integer specifying minimum number cells required spatial microregion compute metacells. ncores Integer specifying number CPU cores use parallel processing (default: 1).","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/GetSpatialMetacells.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Construct Spatial Metacells from Single-Cell Spatial Data — GetSpatialMetacells","text":"matrix containing spatial metacell expression profiles, rows representing individual genes         columns representing metacells.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/GetSpatialMetacells.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Construct Spatial Metacells from Single-Cell Spatial Data — GetSpatialMetacells","text":"","code":"library(data.table) library(Seurat) library(SpatialEcoTyper) library(googledrive) drive_deauth() # no Google sign-in is required drive_download(as_id(\"1CgUOQKrWY_TG61o5aw7J9LZzE20D6NuI\"),                     \"HumanMelanomaPatient1_subset_scmeta.tsv\", overwrite = TRUE) #> File downloaded: #> • HumanMelanomaPatient1_subset_scmeta.tsv #>    #> Saved locally as: #> • HumanMelanomaPatient1_subset_scmeta.tsv drive_download(as_id(\"1CoQmU3u8MoVC8RbLUvTDQmOuJJ703HHB\"),               \"HumanMelanomaPatient1_subset_counts.tsv.gz\", overwrite = TRUE) #> File downloaded: #> • HumanMelanomaPatient1_subset_counts.tsv.gz #>    #> Saved locally as: #> • HumanMelanomaPatient1_subset_counts.tsv.gz scdata <- fread(\"HumanMelanomaPatient1_subset_counts.tsv.gz\",                 sep = \"\\t\",header = TRUE, data.table = FALSE) rownames(scdata) <- scdata[, 1] scdata <- as.matrix(scdata[, -1]) normdata = NormalizeData(scdata) scmeta <- read.table(\"HumanMelanomaPatient1_subset_scmeta.tsv\",                       sep = \"\\t\",header = TRUE, row.names = 1)  # Construct spatial metacells from single-cell spatial data metacells <- GetSpatialMetacells(normdata = normdata, metadata = scmeta,                                  X = \"X\", Y = \"Y\", CellType = \"CellType\") head(metacells) #> 6 x 7711 Matrix of class \"dgeMatrix\" #>          X66_Y-91..B X62_Y-91..B X64_Y-92..B X63_Y-92..B X61_Y-92..B #> PDK4               0    0.000000   0.0000000   0.0000000    0.000000 #> TNFRSF17           0    0.000000   1.6049446   0.9508847    0.000000 #> ICAM3              0    3.056593   2.5135272   3.2732424    2.698584 #> FAP                0    0.000000   0.0000000   0.0000000    0.000000 #> GZMB               0    0.000000   0.8442368   0.0000000    0.000000 #> TSC2               0    0.000000   0.0000000   0.9333217    0.000000 #>          X62_Y-92..B X64_Y-93..B X62_Y-93..B X61_Y-93..B X63_Y-93..B #> PDK4         0.00000    0.000000    0.000000    0.000000   0.0000000 #> TNFRSF17     0.00000    0.383744    0.000000    1.137039   0.5433627 #> ICAM3        2.42756    2.059535    2.478747    3.496900   3.0849468 #> FAP          0.00000    0.000000    0.000000    0.000000   0.0000000 #> GZMB         0.00000    1.672252    0.000000    0.000000   0.6873982 #> TSC2         0.00000    0.000000    0.000000    0.000000   0.5333267 #>          X62_Y-94..B X61_Y-96..B X65_Y-91..B X63_Y-91..B X64_Y-94..B #> PDK4        0.000000     0.00000    0.000000    0.000000    0.000000 #> TNFRSF17    0.000000     2.11725    1.425194    1.148879    0.000000 #> ICAM3       3.586821     2.14130    1.653918    5.075187    1.264459 #> FAP         0.000000     0.00000    0.000000    0.000000    0.000000 #> GZMB        0.000000     0.00000    0.000000    0.000000    1.264459 #> TSC2        0.000000     0.00000    0.000000    0.000000    0.000000 #>          X56_Y-91..B X58_Y-92..B X59_Y-92..B X58_Y-93..B X54_Y-93..B #> PDK4               0      0.0000    0.000000           0           0 #> TNFRSF17           0      0.0000    0.000000           0           0 #> ICAM3              0      2.2414    3.588517           0           0 #> FAP                0      0.0000    0.000000           0           0 #> GZMB               0      0.0000    0.000000           0           0 #> TSC2               0      0.0000    0.000000           0           0 #>          X58_Y-94..B X56_Y-95..B X59_Y-95..B X57_Y-96..B X56_Y-96..B #> PDK4        0.000000   0.0000000           0     0.00000    0.000000 #> TNFRSF17    0.000000   2.6163040           0     1.29846    1.817844 #> ICAM3       4.848761   2.0284363           0     4.24806    3.856029 #> FAP         0.000000   0.0000000           0     0.00000    0.000000 #> GZMB        0.000000   0.6726485           0     0.00000    0.000000 #> TSC2        0.000000   0.0000000           0     0.00000    0.000000 #>          X59_Y-97..B X57_Y-97..B X56_Y-97..B X55_Y-95..B X76_Y-102..B #> PDK4        0.000000    0.000000    0.000000    0.000000     0.000000 #> TNFRSF17    0.000000    1.056955    0.000000    4.567223     2.225693 #> ICAM3       4.706922    1.155021    3.326435    2.209223     2.376547 #> FAP         0.000000    0.000000    0.000000    0.000000     0.000000 #> GZMB        0.000000    0.000000    0.000000    2.354270     0.000000 #> TSC2        0.000000    0.000000    0.000000    0.000000     0.000000 #>          X77_Y-102..B X75_Y-90..B X75_Y-88..B X42_Y-78..B X76_Y-73..B #> PDK4         0.000000    0.000000    0.000000    0.000000    0.000000 #> TNFRSF17     2.225693    0.000000    0.000000    4.163422    3.491864 #> ICAM3        2.376547    4.900324    5.476862    5.537982    4.169673 #> FAP          0.000000    0.000000    0.000000    0.000000    0.000000 #> GZMB         0.000000    0.000000    0.000000    0.000000    0.000000 #> TSC2         0.000000    0.000000    0.000000    0.000000    0.000000 #>          X74_Y-73..B X73_Y-74..B X73_Y-75..B X75_Y-78..B X73_Y-73..B #> PDK4        0.000000    0.000000     0.00000    0.000000    0.000000 #> TNFRSF17    1.215350    0.000000     0.00000    2.058892    1.620467 #> ICAM3       2.579869    3.150018     2.82084    1.720393    5.175989 #> FAP         0.000000    0.000000     0.00000    0.000000    0.000000 #> GZMB        0.000000    0.000000     0.00000    0.000000    0.000000 #> TSC2        0.000000    0.000000     0.00000    0.000000    0.000000 #>          X73_Y-76..B X62_Y-70..B X63_Y-70..B X67_Y-75..B X72_Y-74..B #> PDK4        0.000000    0.000000    0.000000    0.000000    0.000000 #> TNFRSF17    0.000000    4.861401    2.430701    0.000000    2.405894 #> ICAM3       5.727247    4.459799    4.405866    2.146131    2.365282 #> FAP         0.000000    0.000000    0.000000    0.000000    0.000000 #> GZMB        0.000000    3.778150    1.889075    0.000000    0.000000 #> TSC2        0.000000    0.000000    0.000000    0.000000    0.000000 #>          X72_Y-75..B X68_Y-75..B X71_Y-75..B X69_Y-75..B X72_Y-76..B #> PDK4       0.0000000    0.000000    0.000000    0.000000   0.0000000 #> TNFRSF17   0.9891199    0.000000    0.000000    0.000000   1.1521029 #> ICAM3      2.3473298    4.505335    2.119072    4.743091   4.1962180 #> FAP        0.0000000    0.000000    0.000000    0.000000   0.0000000 #> GZMB       0.3010424    0.000000    1.053648    0.000000   0.5268242 #> TSC2       0.0000000    0.000000    0.000000    0.000000   0.0000000 #>          X68_Y-76..B X70_Y-76..B X69_Y-77..B X68_Y-77..B X70_Y-77..B #> PDK4               0   0.0000000    0.000000     0.00000           0 #> TNFRSF17           0   0.7068714    0.635359     0.00000           0 #> ICAM3              0   2.2229375    2.970187     1.81018           0 #> FAP                0   0.0000000    0.000000     0.00000           0 #> GZMB               0   0.0000000    0.000000     0.00000           0 #> TSC2               0   0.0000000    0.000000     0.00000           0 #>          X72_Y-77..B X71_Y-78..B X70_Y-78..B X71_Y-79..B X70_Y-79..B #> PDK4        0.000000   0.0000000    0.000000    0.000000    0.000000 #> TNFRSF17    0.000000   0.5914898    1.171932    0.000000    0.000000 #> ICAM3       4.645283   1.6259953    1.412128    3.682414    4.156191 #> FAP         0.000000   0.0000000    0.000000    0.000000    0.000000 #> GZMB        0.000000   0.4806457    0.000000    0.000000    0.000000 #> TSC2        0.000000   0.0000000    0.000000    0.000000    0.000000 #>          X67_Y-74..B X68_Y-74..B X67_Y-76..B X71_Y-76..B X71_Y-77..B #> PDK4               0    0.000000    0.000000    0.000000    0.000000 #> TNFRSF17           0    0.000000    0.000000    1.432264    1.064682 #> ICAM3              0    1.847129    1.739192    1.795429    2.002926 #> FAP                0    0.000000    0.000000    0.000000    0.000000 #> GZMB               0    0.000000    0.000000    0.000000    0.000000 #> TSC2               0    0.000000    0.000000    0.000000    0.000000 #>          X54_Y-78..B X54_Y-79..B X51_Y-73..B X52_Y-73..B X49_Y-78..B #> PDK4        0.000000    0.000000    0.000000    0.000000    0.000000 #> TNFRSF17    0.000000    1.361292    0.000000    1.470127    1.262179 #> ICAM3       1.194038    2.452523    4.756657    3.204808    2.534343 #> FAP         0.000000    0.000000    0.000000    0.000000    0.000000 #> GZMB        0.000000    0.634420    0.000000    0.000000    0.000000 #> TSC2        0.000000    0.000000    0.000000    0.000000    0.000000 #>          X48_Y-78..B X49_Y-79..B X53_Y-75..B X53_Y-76..B X50_Y-79..B #> PDK4        0.000000    0.000000    0.000000    0.000000    0.000000 #> TNFRSF17    0.000000    0.000000    4.403978    4.459799    1.027227 #> ICAM3       2.481897    2.890517    4.403978    4.459799    2.353053 #> FAP         0.000000    0.000000    0.000000    0.000000    0.000000 #> GZMB        0.000000    0.000000    2.229899    4.459799    0.000000 #> TSC2        0.000000    0.000000    0.000000    0.000000    0.000000 #>          X53_Y-79..B X47_Y-92..B X44_Y-92..B X46_Y-93..B X44_Y-91..B #> PDK4       0.0000000           0    0.000000    0.000000           0 #> TNFRSF17   0.5502978           0    0.000000    0.000000           0 #> ICAM3      3.0141224           0    2.238421    5.057837           0 #> FAP        0.0000000           0    0.000000    0.000000           0 #> GZMB       0.0000000           0    0.000000    0.000000           0 #> TSC2       0.0000000           0    0.000000    5.057837           0 #>          X45_Y-92..B X47_Y-66..B X48_Y-66..B X54_Y-64..B X52_Y-65..B #> PDK4        0.000000    0.000000    0.000000      0.0000   0.0000000 #> TNFRSF17    0.000000    0.000000    0.000000      0.0000   0.9805178 #> ICAM3       2.225693    5.364882    2.322641      1.4115   3.5523383 #> FAP         0.000000    0.000000    0.000000      0.0000   0.0000000 #> GZMB        0.000000    0.000000    0.000000      0.0000   0.0000000 #> TSC2        0.000000    0.000000    0.000000      0.0000   0.0000000 #>          X51_Y-66..B X48_Y-67..B X51_Y-67..B X50_Y-64..B X54_Y-65..B #> PDK4       0.0000000    0.000000      0.0000    0.000000     0.00000 #> TNFRSF17   0.8869554    0.000000      2.1335    0.000000     0.00000 #> ICAM3      0.9710122    3.190812      2.1335    2.166602     2.11725 #> FAP        0.0000000    0.000000      0.0000    0.000000     0.00000 #> GZMB       1.2288870    0.000000      0.0000    0.000000     0.00000 #> TSC2       0.0000000    0.000000      0.0000    0.000000     0.00000 #>          X53_Y-65..B X49_Y-65..B X49_Y-66..B X52_Y-66..B X50_Y-66..B #> PDK4               0    0.000000    0.000000    0.000000    0.000000 #> TNFRSF17           0    1.151317    1.151317    0.000000    0.000000 #> ICAM3              0    0.000000    0.000000    3.345598    2.166602 #> FAP                0    0.000000    0.000000    0.000000    0.000000 #> GZMB               0    0.000000    0.000000    0.000000    3.072218 #> TSC2               0    0.000000    0.000000    0.000000    0.000000 #>          X49_Y-67..B X50_Y-67..B X36_Y-83..B X37_Y-84..B X42_Y-85..B #> PDK4        0.000000    0.000000           0    0.000000   0.0000000 #> TNFRSF17    0.000000    0.000000           0    1.899630   0.6837525 #> ICAM3       3.190812    3.665744           0    1.899630   2.4151935 #> FAP         0.000000    0.000000           0    0.000000   0.0000000 #> GZMB        0.000000    0.000000           0    1.812122   0.2174079 #> TSC2        0.000000    0.000000           0    0.000000   0.0000000 #>          X44_Y-73..B X47_Y-74..B X44_Y-74..B X45_Y-74..B X46_Y-75..B #> PDK4               0           0   0.0000000    0.000000    0.000000 #> TNFRSF17           0           0   0.4543282    0.555290    1.191139 #> ICAM3              0           0   2.1856303    2.161786    2.252606 #> FAP                0           0   0.0000000    0.000000    0.000000 #> GZMB               0           0   0.0000000    0.000000    0.000000 #> TSC2               0           0   0.0000000    0.000000    0.000000 #>          X44_Y-75..B X45_Y-75..B X44_Y-76..B X42_Y-76..B X45_Y-76..B #> PDK4       0.0000000    0.000000    0.000000           0    0.000000 #> TNFRSF17   0.9697523    0.000000    0.000000           0    0.000000 #> ICAM3      1.8213317    2.262653    1.584485           0    3.569047 #> FAP        0.0000000    0.000000    0.000000           0    0.000000 #> GZMB       0.0000000    0.000000    0.000000           0    0.000000 #> TSC2       0.0000000    1.921466    0.000000           0    0.000000 #>          X47_Y-76..B X43_Y-76..B X46_Y-76..B X46_Y-77..B X45_Y-77..B #> PDK4        0.000000   0.0000000   0.0000000   0.0000000    0.000000 #> TNFRSF17    0.000000   0.0000000   0.2104024   0.6125659    1.149039 #> ICAM3       4.346490   1.8942054   2.7932473   3.8361366    3.517611 #> FAP         0.000000   0.0000000   0.0000000   0.0000000    0.000000 #> GZMB        2.076629   0.3997759   0.4153259   0.2671964    0.000000 #> TSC2        0.000000   0.0000000   0.2066379   0.2283413    0.000000 #>          X46_Y-78..B X45_Y-78..B X45_Y-79..B X44_Y-79..B X47_Y-79..B #> PDK4       0.0000000   0.0000000   0.0000000           0   0.0000000 #> TNFRSF17   0.6647316   0.0000000   0.4652812           0   0.6690602 #> ICAM3      1.8095057   2.3311942   3.6685605           0   3.1167736 #> FAP        0.0000000   0.0000000   0.0000000           0   0.0000000 #> GZMB       0.4372764   0.5938873   0.0000000           0   0.0000000 #> TSC2       0.0000000   0.0000000   0.0000000           0   0.3960912 #>          X46_Y-79..B X47_Y-78..B X75_Y-79..B X75_Y-80..B X77_Y-82..B #> PDK4       0.0000000   0.0000000    0.000000    0.000000    0.000000 #> TNFRSF17   0.2491555   0.6433513    0.000000    1.573163    4.836282 #> ICAM3      2.4966915   2.6336547    4.529834    1.802723    0.000000 #> FAP        0.0000000   0.0000000    0.000000    0.000000    0.000000 #> GZMB       0.6265417   0.0000000    0.000000    0.000000    0.000000 #> TSC2       0.2075520   0.0000000    0.000000    0.000000    0.000000 #>          X75_Y-81..B X74_Y-67..B X73_Y-67..B X74_Y-68..B X75_Y-68..B #> PDK4               0   0.0000000    0.000000   0.0000000   0.0000000 #> TNFRSF17           0   0.0000000    0.000000   0.0000000   0.3469518 #> ICAM3              0   3.3201526    3.607293   3.2840292   1.2847042 #> FAP                0   0.0000000    0.000000   0.0000000   0.0000000 #> GZMB               0   0.4019965    0.000000   0.4385417   0.3999805 #> TSC2               0   0.0000000    0.000000   0.4016769   0.0000000 #>          X75_Y-69..B X74_Y-69..B X76_Y-69..B X76_Y-70..B X73_Y-70..B #> PDK4       0.0000000   0.0000000    0.000000           0   0.0000000 #> TNFRSF17   0.3469518   1.0236658    0.000000           0   0.6312631 #> ICAM3      2.9231439   3.7946510    1.588185           0   3.4717022 #> FAP        0.0000000   0.0000000    0.000000           0   0.0000000 #> GZMB       0.7875139   0.5167112    0.000000           0   0.5885675 #> TSC2       0.0000000   0.4909384    0.000000           0   0.0000000 #>          X74_Y-70..B X73_Y-71..B X74_Y-71..B X74_Y-72..B X73_Y-72..B #> PDK4       0.0000000   0.0000000   0.0000000   0.0000000    0.000000 #> TNFRSF17   0.4557445   0.6873982   0.3207858   0.0000000    0.000000 #> ICAM3      3.2332347   4.2071137   3.2907634   2.3859686    4.118722 #> FAP        0.0000000   0.0000000   0.0000000   0.0000000    0.000000 #> GZMB       0.9822268   0.6179731   0.8854903   0.3034288    0.000000 #> TSC2       0.0000000   0.0000000   0.0000000   0.0000000    0.000000 #>          X73_Y-68..B X73_Y-69..B X48_Y-79..B X46_Y-80..B X45_Y-80..B #> PDK4               0    0.000000    0.000000   0.0000000   0.0000000 #> TNFRSF17           0    0.000000    0.000000   0.0000000   0.2260400 #> ICAM3              0    2.470424    2.170326   3.2481627   3.4603199 #> FAP                0    0.000000    0.000000   0.0000000   0.0000000 #> GZMB               0    0.000000    0.000000   0.2284554   0.2221523 #> TSC2               0    0.000000    0.000000   0.2184758   0.2130847 #>          X43_Y-80..B X44_Y-80..B X46_Y-81..B X45_Y-81..B X44_Y-81..B #> PDK4        0.000000   0.0000000    0.000000   0.0000000   0.0000000 #> TNFRSF17    0.000000   0.8083552    0.000000   0.4297029   0.9307104 #> ICAM3       1.960745   1.4005323    4.142261   2.8854139   2.7811556 #> FAP         0.000000   0.0000000    0.000000   0.0000000   0.0000000 #> GZMB        0.000000   0.0000000    1.253864   0.0000000   0.0000000 #> TSC2        0.000000   0.0000000    0.000000   0.0000000   0.0000000 #>          X43_Y-81..B X43_Y-82..B X44_Y-82..B X44_Y-83..B X43_Y-83..B #> PDK4       0.0000000   0.0000000   0.0000000    0.000000   0.0000000 #> TNFRSF17   0.5199608   0.6756255   0.6820723    0.000000   1.1535714 #> ICAM3      2.3077972   2.1366305   2.7427978    4.452312   2.8168004 #> FAP        0.0000000   0.0000000   0.0000000    0.000000   0.0000000 #> GZMB       0.0000000   0.0000000   0.0000000    0.000000   0.6531461 #> TSC2       0.0000000   0.0000000   0.0000000    0.000000   0.0000000 #>          X43_Y-84..B X42_Y-84..B X44_Y-84..B X43_Y-85..B X44_Y-85..B #> PDK4       0.0000000   0.0000000           0   0.0000000   0.0000000 #> TNFRSF17   0.4147101   0.4865075           0   0.0000000   0.0000000 #> ICAM3      3.3261431   2.6702620           0   2.0133817   2.6620434 #> FAP        0.0000000   0.0000000           0   0.0000000   0.0000000 #> GZMB       0.0000000   0.0000000           0   0.2174079   0.6510636 #> TSC2       0.0000000   0.0000000           0   0.0000000   0.0000000 #>          X51_Y-91..B X53_Y-92..B X71_Y-82..B X71_Y-83..B X67_Y-84..B #> PDK4        0.000000           0    0.000000    0.000000    0.000000 #> TNFRSF17    0.000000           0    2.283413    0.000000    0.000000 #> ICAM3       2.120614           0    0.000000    1.429282    2.560989 #> FAP         0.000000           0    0.000000    0.000000    0.000000 #> GZMB        0.000000           0    0.000000    0.000000    0.000000 #> TSC2        0.000000           0    2.283413    0.000000    0.000000 #>          X70_Y-84..B X68_Y-84..B X69_Y-84..B X69_Y-85..B X71_Y-80..B #> PDK4        0.000000    0.000000    0.000000   0.0000000           0 #> TNFRSF17    1.265673    0.000000    0.000000   0.0000000           0 #> ICAM3       3.927594    3.655262    2.975360   3.1011481           0 #> FAP         0.000000    0.000000    0.000000   0.0000000           0 #> GZMB        0.000000    0.000000    1.124994   0.4195564           0 #> TSC2        0.000000    0.000000    0.000000   0.0000000           0 #>          X71_Y-81..B X72_Y-83..B X70_Y-83..B X70_Y-85..B X68_Y-85..B #> PDK4        0.000000    0.000000    0.000000   0.0000000   0.0000000 #> TNFRSF17    2.283413    0.000000    1.784959   0.6608008   0.0000000 #> ICAM3       0.000000    2.491555    2.993083   3.3247117   2.3770512 #> FAP         0.000000    0.000000    0.000000   0.0000000   0.0000000 #> GZMB        0.000000    0.000000    0.000000   0.6173469   0.7691868 #> TSC2        2.283413    0.000000    0.000000   0.0000000   0.0000000 #>          X50_Y-69..B X49_Y-69..B X52_Y-72..B X51_Y-68..B X49_Y-68..B #> PDK4       0.0000000   0.0000000           0    0.000000           0 #> TNFRSF17   0.9152592   0.0000000           0    0.000000           0 #> ICAM3      1.0115674   2.3390514           0    3.122069           0 #> FAP        0.0000000   0.0000000           0    0.000000           0 #> GZMB       0.0000000   0.7504965           0    0.000000           0 #> TSC2       0.0000000   0.7377629           0    0.000000           0 #>          X51_Y-69..B X52_Y-71..B X65_Y-65..B X57_Y-80..B X56_Y-81..B #> PDK4        0.000000           0    0.000000           0    0.000000 #> TNFRSF17    0.000000           0    4.676402           0    0.000000 #> ICAM3       2.031452           0    0.000000           0    3.008576 #> FAP         0.000000           0    0.000000           0    0.000000 #> GZMB        0.000000           0    0.000000           0    0.000000 #> TSC2        0.000000           0    0.000000           0    0.000000 #>          X59_Y-81..B X57_Y-82..B X58_Y-81..B X58_Y-82..B X59_Y-84..B #> PDK4               0    0.000000    0.000000    0.000000           0 #> TNFRSF17           0    2.595287    0.000000    0.000000           0 #> ICAM3              0    2.225693    4.825431    4.825431           0 #> FAP                0    0.000000    0.000000    0.000000           0 #> GZMB               0    0.000000    0.000000    0.000000           0 #> TSC2               0    0.000000    0.000000    0.000000           0 #>          X56_Y-79..B X56_Y-80..B X55_Y-80..B X55_Y-81..B X56_Y-82..B #> PDK4        0.000000           0    0.000000           0    0.000000 #> TNFRSF17    0.000000           0    0.000000           0    1.730191 #> ICAM3       2.552774           0    5.121978           0    1.675755 #> FAP         0.000000           0    0.000000           0    0.000000 #> GZMB        0.000000           0    0.000000           0    0.000000 #> TSC2        0.000000           0    0.000000           0    0.000000 #>          X57_Y-83..B X64_Y-84..B X63_Y-84..B X65_Y-85..B X63_Y-85..B #> PDK4        0.000000    0.000000   0.0000000   0.0000000   0.0000000 #> TNFRSF17    2.595287    0.000000   0.8773159   0.8703865   1.1782220 #> ICAM3       2.312536    2.677175   1.8470682   3.7304454   2.8149688 #> FAP         0.000000    0.000000   0.0000000   0.0000000   0.0000000 #> GZMB        0.000000    0.000000   1.0146972   1.1190904   0.7247837 #> TSC2        0.000000    0.000000   0.0000000   0.0000000   0.0000000 #>          X61_Y-85..B X66_Y-84..B X36_Y-93..B X36_Y-92..B X34_Y-94..B #> PDK4        0.000000    0.000000    0.000000    0.000000           0 #> TNFRSF17    1.132458    0.000000    1.901769    1.541691           0 #> ICAM3       2.473679    5.121978    4.648633    1.325662           0 #> FAP         0.000000    0.000000    0.000000    0.000000           0 #> GZMB        0.000000    0.000000    0.000000    0.000000           0 #> TSC2        1.169100    0.000000    0.000000    0.000000           0 #>          X35_Y-97..B X43_Y-86..B X42_Y-86..B X44_Y-86..B X43_Y-87..B #> PDK4               0   0.0000000    0.000000   0.0000000   0.0000000 #> TNFRSF17           0   0.2269476    0.225149   0.9525449   0.6184871 #> ICAM3              0   3.6483110    1.918486   3.3324674   2.9738375 #> FAP                0   0.0000000    0.000000   0.0000000   0.0000000 #> GZMB               0   0.0000000    0.000000   0.0000000   0.0000000 #> TSC2               0   0.0000000    0.000000   0.0000000   0.0000000 #>          X44_Y-87..B X42_Y-87..B X45_Y-87..B X42_Y-88..B X44_Y-88..B #> PDK4       0.0000000   0.0000000    0.000000    0.000000   0.0000000 #> TNFRSF17   0.6323202   0.2185514    0.000000    0.620909   0.4240316 #> ICAM3      3.5784903   3.0873261    1.555306    3.613346   3.9456665 #> FAP        0.0000000   0.0000000    0.000000    0.000000   0.0000000 #> GZMB       0.0000000   0.1949055    0.000000    0.000000   0.1970840 #> TSC2       0.0000000   0.0000000    1.327379    0.000000   0.0000000 #>          X43_Y-88..B X45_Y-88..B X43_Y-89..B X42_Y-89..B X46_Y-89..B #> PDK4       0.0000000    0.000000   0.0000000   0.0000000   0.0000000 #> TNFRSF17   0.5452494    0.000000   0.6935526   0.2042816   0.7675449 #> ICAM3      3.2789595    1.316071   3.2069784   3.3444017   3.9839161 #> FAP        0.0000000    0.000000   0.0000000   0.0000000   0.0000000 #> GZMB       0.0000000    0.000000   0.0000000   0.2463577   0.7675449 #> TSC2       0.0000000    0.000000   0.1536776   0.0000000   0.0000000 #>          X44_Y-89..B X47_Y-89..B X45_Y-89..B X43_Y-90..B X48_Y-90..B #> PDK4        0.000000    0.000000   0.0000000   0.0000000    0.000000 #> TNFRSF17    1.036512    1.383680   0.4605269   0.2348855    0.000000 #> ICAM3       1.828444    2.983602   2.1614393   3.2628638    2.984646 #> FAP         0.000000    0.000000   0.0000000   0.0000000    0.000000 #> GZMB        0.000000    0.000000   0.4605269   0.0000000    0.000000 #> TSC2        0.000000    0.000000   0.0000000   0.0000000    0.000000 #>          X42_Y-90..B X44_Y-90..B X47_Y-90..B X45_Y-90..B X46_Y-87..B #> PDK4       0.0000000   0.0000000    0.000000    0.000000           0 #> TNFRSF17   0.4603805   0.8529633    2.075520    0.000000           0 #> ICAM3      2.8731964   2.4976425    4.475403    3.055309           0 #> FAP        0.0000000   0.0000000    0.000000    0.000000           0 #> GZMB       0.2307560   0.2094335    0.000000    0.000000           0 #> TSC2       0.0000000   0.0000000    0.000000    0.000000           0 #>          X46_Y-88..B X47_Y-88..B X48_Y-89..B X41_Y-89..B X43_Y-91..B #> PDK4        0.000000           0   0.0000000           0    0.000000 #> TNFRSF17    0.000000           0   0.7350635           0    2.293638 #> ICAM3       2.237996           0   3.1992382           0    3.851602 #> FAP         0.000000           0   0.0000000           0    0.000000 #> GZMB        0.000000           0   0.0000000           0    0.000000 #> TSC2        0.000000           0   0.0000000           0    0.000000 #>          X55_Y-79..B X53_Y-80..B X49_Y-80..B X52_Y-81..B X51_Y-82..B #> PDK4        0.000000    0.000000    0.000000           0    0.000000 #> TNFRSF17    0.000000    0.000000    0.000000           0    0.000000 #> ICAM3       5.242795    2.964811    4.573885           0    4.900324 #> FAP         0.000000    0.000000    0.000000           0    0.000000 #> GZMB        0.000000    0.000000    0.000000           0    0.000000 #> TSC2        0.000000    0.000000    0.000000           0    0.000000 #>          X50_Y-82..B X51_Y-83..B X52_Y-83..B X51_Y-84..B X53_Y-85..B #> PDK4        0.000000    0.000000    0.000000     0.00000    0.000000 #> TNFRSF17    3.780260    3.786538    0.000000     0.00000    2.201191 #> ICAM3       2.234142    4.468283    2.283413     2.03995    4.002774 #> FAP         0.000000    0.000000    0.000000     0.00000    0.000000 #> GZMB        0.000000    0.000000    0.000000     0.00000    0.000000 #> TSC2        0.000000    0.000000    0.000000     0.00000    0.000000 #>          X52_Y-80..B X54_Y-82..B X67_Y-96..B X68_Y-96..B X76_Y-97..B #> PDK4        0.000000           0    0.000000    0.000000    0.000000 #> TNFRSF17    0.000000           0    4.378773    0.000000    0.000000 #> ICAM3       1.500993           0    4.378773    4.940848    4.451387 #> FAP         0.000000           0    0.000000    0.000000    0.000000 #> GZMB        0.000000           0    0.000000    0.000000    0.000000 #> TSC2        0.000000           0    0.000000    0.000000    0.000000 #>          X77_Y-94..B X74_Y-96..B X45_Y-69..B X46_Y-69..B X47_Y-70..B #> PDK4        0.000000    0.000000    0.000000    0.000000    0.000000 #> TNFRSF17    0.000000    0.000000    0.000000    0.000000    0.000000 #> ICAM3       4.836282    4.163422    4.275582    5.305734    1.538374 #> FAP         0.000000    0.000000    0.000000    0.000000    0.000000 #> GZMB        0.000000    0.000000    0.000000    0.000000    0.000000 #> TSC2        0.000000    0.000000    0.000000    0.000000    0.000000 #>          X46_Y-70..B X48_Y-70..B X47_Y-71..B X45_Y-72..B X47_Y-73..B #> PDK4               0     0.00000    0.000000           0      0.0000 #> TNFRSF17           0     0.00000    0.000000           0      0.0000 #> ICAM3              0     3.18383    3.454502           0      2.0371 #> FAP                0     0.00000    0.000000           0      0.0000 #> GZMB               0     0.00000    0.000000           0      0.0000 #> TSC2               0     0.00000    0.000000           0      0.0000 #>          X46_Y-67..B X46_Y-68..B X47_Y-69..B X46_Y-71..B X73_Y-65..B #> PDK4        0.000000    0.000000    0.000000    0.000000     0.00000 #> TNFRSF17    1.088931    1.451907    0.000000    0.000000     0.00000 #> ICAM3       2.349539    3.132718    5.075529    3.454502     2.50247 #> FAP         0.000000    0.000000    0.000000    0.000000     0.00000 #> GZMB        0.000000    0.000000    0.000000    0.000000     0.00000 #> TSC2        0.000000    0.000000    0.000000    0.000000     0.00000 #>          X73_Y-66..B X76_Y-66..B X41_Y-88..B X36_Y-88..B X30_Y-103..B #> PDK4        0.000000     0.00000    0.000000           0     0.000000 #> TNFRSF17    0.000000     0.00000    1.286991           0     0.000000 #> ICAM3       3.433638     4.70854    0.000000           0     4.615121 #> FAP         0.000000     0.00000    0.000000           0     0.000000 #> GZMB        0.000000     0.00000    0.000000           0     0.000000 #> TSC2        0.000000     0.00000    0.000000           0     0.000000 #>          X31_Y-103..B X32_Y-103..B X28_Y-101..B X27_Y-101..B X27_Y-102..B #> PDK4         0.000000     0.000000    0.0000000    0.0000000      0.00000 #> TNFRSF17     0.000000     4.046200    0.0000000    0.0000000      0.00000 #> ICAM3        2.382278     5.133085    3.8252390    3.8252390      5.04754 #> FAP          0.000000     0.000000    0.0000000    0.0000000      0.00000 #> GZMB         0.000000     0.000000    0.9373996    0.9373996      0.00000 #> TSC2         0.000000     0.000000    0.0000000    0.0000000      0.00000 #>          X30_Y-102..B X61_Y-100..B X62_Y-100..B X64_Y-100..B X64_Y-101..B #> PDK4                0     0.000000     0.000000     0.000000    0.0000000 #> TNFRSF17            0     2.197225     0.000000     0.000000    0.8742058 #> ICAM3               0     4.733968     4.576296     3.689523    2.8111273 #> FAP                 0     0.000000     0.000000     0.000000    0.0000000 #> GZMB                0     3.087934     0.000000     0.000000    0.0000000 #> TSC2                0     0.000000     0.000000     0.000000    0.0000000 #>          X63_Y-101..B X64_Y-102..B X64_Y-104..B X65_Y-100..B X65_Y-101..B #> PDK4                0     0.000000     0.000000     0.000000     0.000000 #> TNFRSF17            0     4.655546     0.000000     0.000000     1.092757 #> ICAM3               0     0.000000     2.822176     5.035548     3.610531 #> FAP                 0     0.000000     0.000000     0.000000     0.000000 #> GZMB                0     0.000000     0.000000     0.000000     0.000000 #> TSC2                0     0.000000     0.000000     0.000000     0.000000 #>          X60_Y-102..B X66_Y-102..B X65_Y-102..B X70_Y-86..B X69_Y-86..B #> PDK4         0.000000            0     0.000000   0.0000000    0.000000 #> TNFRSF17     0.000000            0     4.655546   0.5063828    1.067448 #> ICAM3        5.313305            0     4.655546   2.3459965    3.326446 #> FAP          0.000000            0     0.000000   0.0000000    0.000000 #> GZMB         0.000000            0     0.000000   0.0000000    0.000000 #> TSC2         0.000000            0     0.000000   0.4927530    0.000000 #>          X68_Y-86..B X67_Y-86..B X69_Y-87..B X68_Y-87..B X67_Y-87..B #> PDK4        0.000000    0.000000   0.0000000   0.0000000   0.0000000 #> TNFRSF17    1.128071    0.000000   0.0000000   0.4186608   0.9529113 #> ICAM3       3.260184    4.620157   1.8693242   1.2612400   0.0000000 #> FAP         0.000000    0.000000   0.0000000   0.0000000   0.0000000 #> GZMB        0.000000    0.000000   0.0000000   0.0000000   0.0000000 #> TSC2        0.000000    0.000000   0.5543472   0.0000000   0.0000000 #>          X68_Y-88..B X69_Y-89..B X70_Y-87..B X69_Y-88..B X67_Y-88..B #> PDK4               0    0.000000    0.000000           0           0 #> TNFRSF17           0    0.000000    0.000000           0           0 #> ICAM3              0    3.961696    0.000000           0           0 #> FAP                0    0.000000    0.000000           0           0 #> GZMB               0    0.000000    0.000000           0           0 #> TSC2               0    0.000000    2.217389           0           0 #>          X68_Y-90..B X26_Y-107..B X72_Y-100..B X71_Y-101..B X69_Y-104..B #> PDK4        0.000000     0.000000     0.000000     0.000000     0.000000 #> TNFRSF17    0.000000     2.302635     0.000000     2.498805     0.000000 #> ICAM3       5.089387     1.893269     4.635125     3.049536     2.343499 #> FAP         0.000000     0.000000     0.000000     0.000000     0.000000 #> GZMB        0.000000     1.893269     0.000000     0.000000     0.000000 #> TSC2        0.000000     0.000000     0.000000     0.000000     0.000000 #>          X70_Y-104..B X67_Y-104..B X70_Y-105..B X68_Y-106..B X70_Y-106..B #> PDK4                0            0            0     0.000000            0 #> TNFRSF17            0            0            0     0.000000            0 #> ICAM3               0            0            0     0.000000            0 #> FAP                 0            0            0     0.000000            0 #> GZMB                0            0            0     4.169673            0 #> TSC2                0            0            0     0.000000            0 #>          X63_Y-105..B X66_Y-106..B X52_Y-105..B X31_Y-104..B X33_Y-104..B #> PDK4                0            0            0            0     0.000000 #> TNFRSF17            0            0            0            0     0.000000 #> ICAM3               0            0            0            0     5.350863 #> FAP                 0            0            0            0     0.000000 #> GZMB                0            0            0            0     0.000000 #> TSC2                0            0            0            0     0.000000 #>          X35_Y-104..B X56_Y-98..B X58_Y-98..B X56_Y-99..B X59_Y-99..B #> PDK4                0   0.0000000    0.000000     0.00000    0.000000 #> TNFRSF17            0   0.7298883    0.000000     1.21648    0.000000 #> ICAM3               0   2.6164556    3.532434     1.21648    4.964721 #> FAP                 0   0.0000000    0.000000     0.00000    0.000000 #> GZMB                0   0.0000000    0.000000     0.00000    0.000000 #> TSC2                0   0.0000000    0.000000     0.00000    0.000000 #>          X56_Y-102..B X59_Y-98..B X58_Y-99..B X58_Y-100..B X42_Y-100..B #> PDK4         0.000000    0.000000    0.000000            0            0 #> TNFRSF17     4.913648    0.000000    0.000000            0            0 #> ICAM3        5.603116    3.532434    4.968821            0            0 #> FAP          0.000000    0.000000    0.000000            0            0 #> GZMB         0.000000    0.000000    0.000000            0            0 #> TSC2         0.000000    0.000000    0.000000            0            0 #>          X41_Y-101..B X41_Y-103..B X62_Y-85..B X64_Y-85..B X66_Y-86..B #> PDK4         0.000000            0           0   0.0000000   0.0000000 #> TNFRSF17     0.000000            0           0   1.3688179   0.0000000 #> ICAM3        2.646702            0           0   5.0343697   3.7583304 #> FAP          0.000000            0           0   0.0000000   0.0000000 #> GZMB         0.000000            0           0   0.9325753   0.0000000 #> TSC2         0.000000            0           0   0.0000000   0.9748411 #>          X63_Y-86..B X62_Y-86..B X65_Y-86..B X66_Y-87..B X65_Y-87..B #> PDK4        0.000000           0    0.000000   0.0000000    0.000000 #> TNFRSF17    0.000000           0    0.000000   0.6640457    0.000000 #> ICAM3       2.170326           0    2.948429   2.7503651    2.121432 #> FAP         0.000000           0    0.000000   0.0000000    0.000000 #> GZMB        0.000000           0    0.000000   0.0000000    0.000000 #> TSC2        0.000000           0    0.000000   0.0000000    0.000000 #>          X63_Y-87..B X62_Y-89..B X63_Y-89..B X64_Y-89..B X63_Y-90..B #> PDK4        0.000000    0.000000           0           0   0.0000000 #> TNFRSF17    4.182296    0.000000           0           0   0.9191032 #> ICAM3       0.000000    2.614978           0           0   4.8600150 #> FAP         0.000000    0.000000           0           0   0.0000000 #> GZMB        0.000000    1.509945           0           0   0.0000000 #> TSC2        0.000000    0.000000           0           0   0.0000000 #>          X65_Y-90..B X64_Y-90..B X66_Y-85..B X61_Y-86..B X62_Y-87..B #> PDK4        0.000000   0.0000000    0.000000    0.000000           0 #> TNFRSF17    3.054253   0.9774357    0.000000    0.000000           0 #> ICAM3       3.549709   2.0727552    2.437103    1.788294           0 #> FAP         0.000000   0.0000000    0.000000    0.000000           0 #> GZMB        0.000000   0.0000000    0.000000    0.000000           0 #> TSC2        0.000000   0.0000000    2.437103    1.558801           0 #>          X62_Y-90..B X64_Y-91..B X41_Y-92..B X40_Y-94..B X42_Y-96..B #> PDK4        0.000000    0.000000    0.000000    0.000000     0.00000 #> TNFRSF17    0.000000    0.000000    0.000000    0.000000     0.00000 #> ICAM3       4.529834    1.776734    3.364981    5.057837     4.69771 #> FAP         0.000000    0.000000    0.000000    0.000000     0.00000 #> GZMB        4.529834    0.000000    4.725012    0.000000     0.00000 #> TSC2        0.000000    0.000000    0.000000    0.000000     0.00000 #>          X42_Y-92..B X40_Y-105..B X41_Y-106..B X40_Y-107..B X40_Y-104..B #> PDK4        0.000000            0            0     0.000000     0.000000 #> TNFRSF17    0.000000            0            0     0.000000     0.000000 #> ICAM3       5.073486            0            0     2.247962     5.612132 #> FAP         0.000000            0            0     0.000000     0.000000 #> GZMB        0.000000            0            0     0.000000     4.520800 #> TSC2        0.000000            0            0     0.000000     0.000000 #>          X40_Y-106..B X52_Y-85..B X53_Y-86..B X49_Y-88..B X48_Y-88..B #> PDK4         0.000000    0.000000    0.000000           0    0.000000 #> TNFRSF17     0.000000    2.518675    4.402383           0    0.000000 #> ICAM3        2.997283    1.975818    4.402383           0    5.823279 #> FAP          0.000000    0.000000    0.000000           0    0.000000 #> GZMB         0.000000    0.000000    0.000000           0    0.000000 #> TSC2         0.000000    2.124001    0.000000           0    0.000000 #>          X54_Y-88..B X54_Y-89..B X50_Y-89..B X49_Y-90..B X50_Y-90..B #> PDK4        0.000000    0.000000           0    0.000000    0.000000 #> TNFRSF17    0.000000    0.000000           0    0.000000    0.000000 #> ICAM3       4.747414    4.858117           0    2.664418    2.165482 #> FAP         0.000000    0.000000           0    0.000000    0.000000 #> GZMB        0.000000    0.000000           0    0.000000    0.000000 #> TSC2        0.000000    0.000000           0    0.000000    0.000000 #>          X51_Y-90..B X49_Y-89..B X56_Y-87..B X56_Y-89..B X54_Y-90..B #> PDK4        0.000000    0.000000           0           0    0.000000 #> TNFRSF17    0.000000    4.611084           0           0    3.807837 #> ICAM3       2.288148    0.000000           0           0    3.807837 #> FAP         0.000000    0.000000           0           0    0.000000 #> GZMB        0.000000    0.000000           0           0    0.000000 #> TSC2        0.000000    0.000000           0           0    0.000000 #>          X55_Y-90..B X58_Y-91..B X57_Y-91..B X57_Y-88..B X55_Y-65..B #> PDK4               0    0.000000    0.000000           0    0.000000 #> TNFRSF17           0    0.000000    0.000000           0    0.000000 #> ICAM3              0    1.771102    5.313305           0    4.195087 #> FAP                0    0.000000    0.000000           0    0.000000 #> GZMB               0    0.000000    0.000000           0    0.000000 #> TSC2               0    0.000000    0.000000           0    0.000000 #>          X72_Y-64..B X72_Y-65..B X72_Y-66..B X49_Y-100..B X54_Y-103..B #> PDK4        0.000000    0.000000    0.000000      0.00000     0.000000 #> TNFRSF17    0.000000    0.000000    0.000000      0.00000     4.426577 #> ICAM3       4.544179    3.029452    1.665870      4.38658     0.000000 #> FAP         0.000000    0.000000    0.000000      0.00000     0.000000 #> GZMB        0.000000    0.000000    1.548428      0.00000     0.000000 #> TSC2        0.000000    0.000000    0.000000      0.00000     0.000000 #>          X44_Y-98..B X26_Y-96..CD4T X26_Y-97..CD4T X27_Y-98..CD4T #> PDK4               0       0.000000        0.00000      0.0000000 #> TNFRSF17           0       0.000000        0.00000      0.0000000 #> ICAM3              0       3.065884        3.94624      4.0085034 #> FAP                0       0.000000        0.00000      0.0000000 #> GZMB               0       0.000000        0.00000      0.0000000 #> TSC2               0       0.000000        0.00000      0.7731077 #>          X27_Y-96..CD4T X24_Y-96..CD4T X63_Y-91..CD4T X64_Y-91..CD4T #> PDK4                  0        0.00000       0.000000       0.000000 #> TNFRSF17              0        0.00000       0.000000       0.000000 #> ICAM3                 0        5.50086       3.539812       2.402751 #> FAP                   0        0.00000       0.000000       0.000000 #> GZMB                  0        0.00000       0.000000       0.714496 #> TSC2                  0        0.00000       0.000000       0.000000 #>          X62_Y-91..CD4T X64_Y-92..CD4T X61_Y-92..CD4T X62_Y-92..CD4T #> PDK4          0.0000000       0.000000      0.0000000      0.0000000 #> TNFRSF17      0.0000000       0.000000      0.0000000      0.0000000 #> ICAM3         3.2447005       2.960047      2.6487423      3.4995989 #> FAP           0.0000000       0.000000      0.0000000      0.0000000 #> GZMB          0.9125695       0.000000      0.0000000      0.2750825 #> TSC2          0.2735358       0.463333      0.2342835      0.0000000 #>          X63_Y-92..CD4T X62_Y-93..CD4T X65_Y-93..CD4T X61_Y-93..CD4T #> PDK4          0.0000000      0.0000000       0.000000        0.00000 #> TNFRSF17      0.0000000      0.0000000       0.000000        0.00000 #> ICAM3         3.2052549      3.6634460       1.420565        5.09924 #> FAP           0.0000000      0.0000000       0.000000        0.00000 #> GZMB          0.2590867      0.5188492       0.000000        0.00000 #> TSC2          0.0000000      0.0000000       0.000000        0.00000 #>          X63_Y-93..CD4T X64_Y-93..CD4T X65_Y-95..CD4T X61_Y-96..CD4T #> PDK4          0.0000000         0.0000              0       0.000000 #> TNFRSF17      0.0000000         0.0000              0       0.000000 #> ICAM3         3.3914567         2.0018              0       2.292929 #> FAP           0.0000000         0.0000              0       0.000000 #> GZMB          0.3454489         0.0000              0       0.000000 #> TSC2          0.0000000         0.0000              0       0.000000 #>          X62_Y-96..CD4T X61_Y-97..CD4T X61_Y-98..CD4T X60_Y-91..CD4T #> PDK4           0.000000       0.000000       0.000000        0.00000 #> TNFRSF17       0.000000       0.000000       0.000000        0.00000 #> ICAM3          5.364882       2.120614       4.353076        1.18887 #> FAP            0.000000       0.000000       0.000000        0.00000 #> GZMB           0.000000       0.000000       0.000000        0.00000 #> TSC2           0.000000       0.000000       0.000000        0.00000 #>          X65_Y-91..CD4T X61_Y-91..CD4T X64_Y-94..CD4T X64_Y-95..CD4T #> PDK4           0.000000       0.000000      0.0000000       0.000000 #> TNFRSF17       0.000000       0.000000      0.0000000       0.000000 #> ICAM3          2.489443       2.310581      0.7225481       5.138686 #> FAP            0.000000       0.000000      0.0000000       0.000000 #> GZMB           0.000000       0.000000      0.0000000       0.000000 #> TSC2           0.000000       0.000000      0.0000000       0.000000 #>          X63_Y-95..CD4T X62_Y-95..CD4T X61_Y-95..CD4T X58_Y-91..CD4T #> PDK4           0.000000              0       0.000000       0.000000 #> TNFRSF17       0.000000              0       0.000000       0.000000 #> ICAM3          2.544693              0       5.658486       3.247841 #> FAP            0.000000              0       0.000000       0.000000 #> GZMB           0.000000              0       0.000000       0.000000 #> TSC2           0.000000              0       0.000000       0.000000 #>          X56_Y-91..CD4T X59_Y-91..CD4T X57_Y-91..CD4T X54_Y-91..CD4T #> PDK4           0.000000       0.000000      0.0000000              0 #> TNFRSF17       0.000000       0.000000      0.0000000              0 #> ICAM3          1.317707       3.605486      2.9268663              0 #> FAP            0.000000       0.000000      0.0000000              0 #> GZMB           0.000000       0.000000      0.0000000              0 #> TSC2           0.000000       0.000000      0.2696462              0 #>          X56_Y-92..CD4T X59_Y-92..CD4T X57_Y-92..CD4T X60_Y-92..CD4T #> PDK4           0.000000       0.000000              0      0.0000000 #> TNFRSF17       0.000000       0.000000              0      0.0000000 #> ICAM3          1.645508       1.527549              0      1.9806193 #> FAP            0.000000       0.000000              0      0.0000000 #> GZMB           0.000000       0.000000              0      0.0000000 #> TSC2           0.000000       0.000000              0      0.6359124 #>          X55_Y-92..CD4T X58_Y-92..CD4T X60_Y-93..CD4T X59_Y-93..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.449214       3.446105       2.652644       2.574504 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X54_Y-93..CD4T X55_Y-93..CD4T X58_Y-93..CD4T X56_Y-93..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          1.807006       1.718587       1.651578       5.257927 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X57_Y-93..CD4T X55_Y-94..CD4T X57_Y-94..CD4T X56_Y-94..CD4T #> PDK4           0.000000      0.0000000       0.000000       0.000000 #> TNFRSF17       0.000000      0.0000000       0.000000       0.000000 #> ICAM3          2.521216      2.3586099       1.680811       2.741661 #> FAP            0.000000      0.0000000       0.000000       0.000000 #> GZMB           0.000000      0.2513632       0.000000       0.000000 #> TSC2           0.000000      0.0000000       0.000000       0.000000 #>          X60_Y-94..CD4T X59_Y-94..CD4T X54_Y-94..CD4T X57_Y-95..CD4T #> PDK4            0.00000       0.000000       0.000000       0.000000 #> TNFRSF17        0.00000       0.000000       0.000000       0.000000 #> ICAM3           3.21031       4.275866       1.859391       2.652738 #> FAP             0.00000       0.000000       0.000000       0.000000 #> GZMB            0.00000       0.000000       1.005453       0.000000 #> TSC2            0.00000       0.000000       0.000000       0.000000 #>          X56_Y-95..CD4T X59_Y-95..CD4T X55_Y-95..CD4T X56_Y-96..CD4T #> PDK4           0.000000       0.000000       0.000000      0.0000000 #> TNFRSF17       0.000000       0.000000       0.000000      0.0000000 #> ICAM3          2.699097       4.587234       2.781063      3.1043649 #> FAP            0.000000       0.000000       0.000000      0.0000000 #> GZMB           0.000000       0.000000       0.000000      0.2189387 #> TSC2           0.000000       0.000000       0.000000      0.2343499 #>          X58_Y-96..CD4T X57_Y-96..CD4T X55_Y-96..CD4T X59_Y-96..CD4T #> PDK4           0.000000      0.0000000       0.000000        0.00000 #> TNFRSF17       0.000000      0.0000000       0.000000        0.00000 #> ICAM3          1.972455      3.1166299       1.841818        2.19329 #> FAP            0.000000      0.0000000       0.000000        0.00000 #> GZMB           0.000000      0.2189387       0.000000        0.00000 #> TSC2           0.000000      0.4720046       0.000000        0.00000 #>          X55_Y-97..CD4T X57_Y-97..CD4T X56_Y-97..CD4T X58_Y-97..CD4T #> PDK4           0.000000      0.0000000      0.0000000        0.00000 #> TNFRSF17       0.000000      0.0000000      0.0000000        0.00000 #> ICAM3          3.552443      2.2168620      2.2370799        1.65813 #> FAP            0.000000      0.0000000      0.0000000        0.00000 #> GZMB           0.000000      0.0000000      0.2075520        0.00000 #> TSC2           0.372357      0.2376547      0.2376547        0.00000 #>          X59_Y-97..CD4T X55_Y-91..CD4T X56_Y-98..CD4T X74_Y-98..CD4T #> PDK4           0.000000       0.000000      0.0000000              0 #> TNFRSF17       0.000000       0.000000      0.0000000              0 #> ICAM3          2.327773       1.810957      3.1893808              0 #> FAP            0.000000       0.000000      0.0000000              0 #> GZMB           0.000000       0.000000      0.0000000              0 #> TSC2           0.000000       0.000000      0.4297512              0 #>          X73_Y-98..CD4T X76_Y-98..CD4T X78_Y-98..CD4T X77_Y-99..CD4T #> PDK4           0.000000      0.0000000       0.000000       0.000000 #> TNFRSF17       0.000000      0.0000000       0.000000       0.000000 #> ICAM3          3.054983      0.7493335       5.303305       2.928529 #> FAP            0.000000      0.0000000       0.000000       0.000000 #> GZMB           0.000000      0.0000000       0.000000       0.000000 #> TSC2           0.000000      0.0000000       0.000000       0.000000 #>          X76_Y-99..CD4T X76_Y-100..CD4T X77_Y-100..CD4T X75_Y-101..CD4T #> PDK4           0.000000        0.000000        0.000000        0.000000 #> TNFRSF17       0.000000        0.000000        0.000000        0.000000 #> ICAM3          1.650147        5.264283        4.451387        3.912415 #> FAP            0.000000        0.000000        0.000000        0.000000 #> GZMB           0.000000        0.000000        0.000000        0.000000 #> TSC2           0.000000        0.000000        0.000000        0.000000 #>          X74_Y-101..CD4T X75_Y-102..CD4T X78_Y-102..CD4T X73_Y-103..CD4T #> PDK4                   0        0.000000        0.000000        0.000000 #> TNFRSF17               0        0.000000        0.000000        0.000000 #> ICAM3                  0        4.625072        4.585859        2.638130 #> FAP                    0        0.000000        0.000000        0.000000 #> GZMB                   0        0.000000        0.000000        1.218551 #> TSC2                   0        0.000000        0.000000        0.000000 #>          X76_Y-103..CD4T X77_Y-103..CD4T X76_Y-97..CD4T X77_Y-102..CD4T #> PDK4            0.000000        0.000000       0.000000        0.000000 #> TNFRSF17        0.000000        0.000000       0.000000        0.000000 #> ICAM3           5.460237        1.841818       3.189952        2.762726 #> FAP             0.000000        0.000000       0.000000        0.000000 #> GZMB            0.000000        0.000000       0.000000        0.000000 #> TSC2            0.000000        0.000000       0.000000        0.000000 #>          X76_Y-104..CD4T X78_Y-85..CD4T X73_Y-85..CD4T X75_Y-86..CD4T #> PDK4            0.000000       0.000000       0.000000       0.000000 #> TNFRSF17        0.000000       0.000000       0.000000       0.000000 #> ICAM3           5.027855       2.405894       5.303305       4.686998 #> FAP             0.000000       0.000000       0.000000       0.000000 #> GZMB            0.000000       0.000000       0.000000       0.000000 #> TSC2            0.000000       0.000000       0.000000       0.000000 #>          X78_Y-88..CD4T X75_Y-89..CD4T X77_Y-90..CD4T X32_Y-74..CD4T #> PDK4                  0       0.000000       0.000000       0.000000 #> TNFRSF17              0       0.000000       0.000000       0.000000 #> ICAM3                 0       6.121496       5.364882       4.605269 #> FAP                   0       0.000000       0.000000       0.000000 #> GZMB                  0       0.000000       0.000000       0.000000 #> TSC2                  0       0.000000       0.000000       0.000000 #>          X33_Y-79..CD4T X31_Y-73..CD4T X40_Y-72..CD4T X38_Y-71..CD4T #> PDK4                  0        0.00000        0.00000              0 #> TNFRSF17              0        0.00000        0.00000              0 #> ICAM3                 0        5.00494        2.61645              0 #> FAP                   0        0.00000        0.00000              0 #> GZMB                  0        0.00000        0.00000              0 #> TSC2                  0        0.00000        0.00000              0 #>          X37_Y-74..CD4T X40_Y-75..CD4T X37_Y-75..CD4T X39_Y-75..CD4T #> PDK4           0.000000       0.000000              0              0 #> TNFRSF17       0.000000       0.000000              0              0 #> ICAM3          4.557445       3.286341              0              0 #> FAP            0.000000       0.000000              0              0 #> GZMB           4.557445       0.000000              0              0 #> TSC2           0.000000       0.000000              0              0 #>          X38_Y-77..CD4T X42_Y-78..CD4T X38_Y-74..CD4T X77_Y-72..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          5.283602       5.880932       5.283602       1.696462 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       3.912415       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X76_Y-73..CD4T X73_Y-73..CD4T X75_Y-73..CD4T X77_Y-74..CD4T #> PDK4            0.00000      0.0000000       0.000000       0.000000 #> TNFRSF17        0.00000      0.0000000       0.000000       0.000000 #> ICAM3           1.83633      2.9097494       5.121978       2.601444 #> FAP             0.00000      0.0000000       0.000000       0.000000 #> GZMB            0.00000      0.0000000       0.000000       0.000000 #> TSC2            0.00000      0.3079424       0.000000       0.000000 #>          X76_Y-74..CD4T X78_Y-74..CD4T X73_Y-74..CD4T X75_Y-74..CD4T #> PDK4           0.000000              0      0.0000000              0 #> TNFRSF17       0.000000              0      0.0000000              0 #> ICAM3          2.826767              0      1.2482486              0 #> FAP            0.000000              0      0.0000000              0 #> GZMB           0.000000              0      0.6060952              0 #> TSC2           0.000000              0      0.0000000              0 #>          X77_Y-75..CD4T X76_Y-75..CD4T X75_Y-75..CD4T X72_Y-75..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          4.927321       4.036619       3.753336       2.032744 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X74_Y-75..CD4T X76_Y-76..CD4T X74_Y-76..CD4T X77_Y-76..CD4T #> PDK4                  0       0.000000       0.000000        0.00000 #> TNFRSF17              0       0.000000       0.000000        0.00000 #> ICAM3                 0       1.489428       1.274359        2.19329 #> FAP                   0       0.000000       0.000000        0.00000 #> GZMB                  0       0.000000       0.000000        0.00000 #> TSC2                  0       0.000000       0.000000        0.00000 #>          X78_Y-76..CD4T X73_Y-76..CD4T X72_Y-76..CD4T X75_Y-77..CD4T #> PDK4           0.000000       0.000000      0.0000000       0.000000 #> TNFRSF17       0.000000       0.000000      0.0000000       0.000000 #> ICAM3          4.040696       1.325826      0.9054755       2.632142 #> FAP            0.000000       0.000000      0.0000000       0.000000 #> GZMB           4.040696       0.000000      0.0000000       0.000000 #> TSC2           0.000000       0.000000      0.0000000       0.000000 #>          X76_Y-77..CD4T X75_Y-78..CD4T X76_Y-78..CD4T X77_Y-79..CD4T #> PDK4           0.000000       0.000000              0        0.00000 #> TNFRSF17       0.000000       0.000000              0        0.00000 #> ICAM3          2.632142       1.384495              0        3.79076 #> FAP            0.000000       0.000000              0        0.00000 #> GZMB           0.000000       0.000000              0        0.00000 #> TSC2           0.000000       0.000000              0        0.00000 #>          X78_Y-79..CD4T X65_Y-67..CD4T X61_Y-69..CD4T X63_Y-69..CD4T #> PDK4           0.000000       0.000000              0        0.00000 #> TNFRSF17       0.000000       0.000000              0        0.00000 #> ICAM3          4.820628       4.254824              0        3.61014 #> FAP            0.000000       0.000000              0        0.00000 #> GZMB           2.234142       0.000000              0        0.00000 #> TSC2           0.000000       0.000000              0        0.00000 #>          X62_Y-69..CD4T X62_Y-70..CD4T X63_Y-70..CD4T X61_Y-71..CD4T #> PDK4                  0        0.00000        0.00000        0.00000 #> TNFRSF17              0        0.00000        0.00000        0.00000 #> ICAM3                 0        2.23648        2.23648        1.50395 #> FAP                   0        0.00000        0.00000        0.00000 #> GZMB                  0        0.00000        0.00000        0.00000 #> TSC2                  0        0.00000        0.00000        0.00000 #>          X64_Y-72..CD4T X65_Y-73..CD4T X66_Y-73..CD4T X64_Y-71..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.014891       1.884917       1.761771       2.209223 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           2.014891       0.000000       0.000000       0.000000 #>          X65_Y-72..CD4T X63_Y-73..CD4T X67_Y-73..CD4T X65_Y-74..CD4T #> PDK4           0.000000              0      0.0000000       0.000000 #> TNFRSF17       0.000000              0      0.0000000       0.000000 #> ICAM3          2.599872              0      0.8081269       3.438233 #> FAP            0.000000              0      0.0000000       0.000000 #> GZMB           0.000000              0      0.0000000       0.000000 #> TSC2           1.343260              0      0.0000000       0.000000 #>          X64_Y-74..CD4T X66_Y-75..CD4T X65_Y-75..CD4T X67_Y-77..CD4T #> PDK4            0.00000       0.000000       0.000000       0.000000 #> TNFRSF17        0.00000       0.000000       0.000000       0.000000 #> ICAM3           3.08498       3.153173       1.467283       2.584518 #> FAP             0.00000       0.000000       0.000000       0.000000 #> GZMB            0.00000       0.000000       0.000000       0.000000 #> TSC2            0.00000       0.000000       0.000000       0.000000 #>          X61_Y-73..CD4T X67_Y-74..CD4T X66_Y-76..CD4T X66_Y-77..CD4T #> PDK4           0.000000      0.0000000        0.00000       0.000000 #> TNFRSF17       0.000000      0.0000000        0.00000       0.000000 #> ICAM3          4.538951      1.0345371        4.22782       2.584518 #> FAP            0.000000      0.0000000        0.00000       0.000000 #> GZMB           0.000000      0.5000782        0.00000       0.000000 #> TSC2           0.000000      0.0000000        4.22782       0.000000 #>          X72_Y-73..CD4T X72_Y-74..CD4T X68_Y-74..CD4T X71_Y-75..CD4T #> PDK4           0.000000      0.0000000      0.0000000       0.000000 #> TNFRSF17       0.000000      0.0000000      0.0000000       0.000000 #> ICAM3          2.162197      1.6292058      3.0596493       1.155555 #> FAP            0.000000      0.0000000      0.0000000       0.000000 #> GZMB           0.000000      0.3232508      0.2895189       0.000000 #> TSC2           0.000000      0.0000000      0.0000000       0.000000 #>          X69_Y-75..CD4T X68_Y-75..CD4T X67_Y-75..CD4T X73_Y-75..CD4T #> PDK4          0.0000000       0.000000        0.00000       0.000000 #> TNFRSF17      0.0000000       0.000000        0.00000       0.000000 #> ICAM3         3.3821229       4.289524        2.08581       2.487806 #> FAP           0.0000000       0.000000        0.00000       0.000000 #> GZMB          0.0000000       0.000000        0.00000       0.000000 #> TSC2          0.3123506       0.000000        0.00000       0.000000 #>          X69_Y-76..CD4T X68_Y-76..CD4T X67_Y-76..CD4T X71_Y-76..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          3.047288       2.247907       1.602073       3.473269 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X70_Y-76..CD4T X69_Y-77..CD4T X71_Y-77..CD4T X70_Y-77..CD4T #> PDK4          0.0000000      0.0000000       0.000000       0.000000 #> TNFRSF17      0.0000000      0.0000000       0.000000       0.000000 #> ICAM3         4.0868514      3.0856368       3.866558       3.908443 #> FAP           0.0000000      0.0000000       0.000000       0.000000 #> GZMB          0.5520912      0.1988493       0.000000       0.000000 #> TSC2          0.0000000      0.0000000       0.000000       0.000000 #>          X72_Y-77..CD4T X71_Y-78..CD4T X69_Y-78..CD4T X70_Y-78..CD4T #> PDK4           0.000000      0.0000000      0.0000000      0.0000000 #> TNFRSF17       0.000000      0.0000000      0.0000000      0.0000000 #> ICAM3          2.643846      2.2127911      2.0131060      2.8925060 #> FAP            0.000000      0.0000000      0.0000000      0.0000000 #> GZMB           0.000000      0.5144518      0.2001511      0.2411979 #> TSC2           0.000000      0.0000000      0.0000000      0.0000000 #>          X72_Y-78..CD4T X70_Y-79..CD4T X71_Y-79..CD4T X71_Y-74..CD4T #> PDK4           0.000000      0.0000000      0.0000000       0.000000 #> TNFRSF17       0.000000      0.0000000      0.0000000       0.000000 #> ICAM3          3.307508      3.0361559      3.2645628       1.489459 #> FAP            0.000000      0.0000000      0.0000000       0.000000 #> GZMB           0.000000      0.3030476      0.2369989       0.000000 #> TSC2           0.000000      0.0000000      0.0000000       0.000000 #>          X68_Y-77..CD4T X58_Y-74..CD4T X54_Y-77..CD4T X55_Y-78..CD4T #> PDK4          0.0000000       0.000000      0.0000000        0.00000 #> TNFRSF17      0.0000000       0.000000      0.0000000        0.00000 #> ICAM3         2.5199497       2.004158      2.6390275        2.80005 #> FAP           0.0000000       0.000000      0.0000000        0.00000 #> GZMB          0.2209437       1.878748      0.3897001        0.00000 #> TSC2          0.0000000       0.000000      0.0000000        0.00000 #>          X54_Y-78..CD4T X56_Y-79..CD4T X55_Y-79..CD4T X54_Y-79..CD4T #> PDK4           0.000000        0.00000       0.000000      0.0000000 #> TNFRSF17       0.000000        0.00000       0.000000      0.0000000 #> ICAM3          1.890642        1.83463       3.610104      2.9299549 #> FAP            0.000000        0.00000       0.000000      0.0000000 #> GZMB           0.000000        0.00000       0.000000      0.5121822 #> TSC2           0.000000        0.00000       0.000000      0.0000000 #>          X73_Y-66..CD4T X73_Y-67..CD4T X68_Y-67..CD4T X73_Y-68..CD4T #> PDK4          0.0000000      0.0000000              0      0.0000000 #> TNFRSF17      0.0000000      0.0000000              0      0.0000000 #> ICAM3         2.5303233      2.7020591              0      2.4101008 #> FAP           0.0000000      0.0000000              0      0.0000000 #> GZMB          0.0000000      0.2338201              0      0.4589269 #> TSC2          0.5249983      0.0000000              0      0.2399883 #>          X69_Y-69..CD4T X72_Y-69..CD4T X73_Y-69..CD4T X70_Y-70..CD4T #> PDK4                  0        0.00000      0.0000000       0.000000 #> TNFRSF17              0        0.00000      0.0000000       0.000000 #> ICAM3                 0        0.00000      2.5002902       4.787888 #> FAP                   0        0.00000      0.0000000       0.000000 #> GZMB                  0        0.00000      0.3788075       0.000000 #> TSC2                  0        4.99761      0.0000000       0.000000 #>          X73_Y-70..CD4T X72_Y-71..CD4T X67_Y-71..CD4T X72_Y-72..CD4T #> PDK4           0.000000      0.0000000              0      0.0000000 #> TNFRSF17       0.000000      0.0000000              0      0.0000000 #> ICAM3          2.746235      2.0443150              0      2.7766650 #> FAP            0.000000      0.0000000              0      0.0000000 #> GZMB           0.000000      0.4968785              0      0.8517918 #> TSC2           0.000000      0.0000000              0      0.0000000 #>          X73_Y-72..CD4T X69_Y-68..CD4T X72_Y-68..CD4T X72_Y-70..CD4T #> PDK4           0.000000              0        0.00000              0 #> TNFRSF17       0.000000              0        0.00000              0 #> ICAM3          4.084259              0        5.44192              0 #> FAP            0.000000              0        0.00000              0 #> GZMB           1.426902              0        0.00000              0 #> TSC2           0.000000              0        0.00000              0 #>          X73_Y-71..CD4T X52_Y-73..CD4T X49_Y-73..CD4T X53_Y-74..CD4T #> PDK4           0.000000      0.0000000         0.0000      0.0000000 #> TNFRSF17       0.000000      0.0000000         0.0000      0.0000000 #> ICAM3          2.595133      2.6717415         4.0799      2.2137032 #> FAP            0.000000      0.0000000         0.0000      0.0000000 #> GZMB           0.376948      0.0000000         0.0000      0.8089178 #> TSC2           0.000000      0.2264917         0.0000      0.0000000 #>          X52_Y-74..CD4T X53_Y-75..CD4T X52_Y-75..CD4T X53_Y-76..CD4T #> PDK4          0.0000000      0.0000000      0.0000000      0.0000000 #> TNFRSF17      0.0000000      0.0000000      0.0000000      0.0000000 #> ICAM3         2.7127532      2.4103171      2.4600836      3.7515088 #> FAP           0.0000000      0.0000000      0.0000000      0.0000000 #> GZMB          0.4793066      0.4355722      0.0000000      0.0000000 #> TSC2          0.0000000      0.4035223      0.5044029      0.6771505 #>          X54_Y-76..CD4T X48_Y-77..CD4T X49_Y-78..CD4T X48_Y-78..CD4T #> PDK4          0.0000000       0.000000       0.000000       0.000000 #> TNFRSF17      0.0000000       0.000000       0.000000       0.000000 #> ICAM3         2.3163880       2.300271       2.396969       2.699894 #> FAP           0.0000000       0.000000       0.000000       0.000000 #> GZMB          0.5196002       0.000000       0.000000       0.000000 #> TSC2          0.0000000       0.000000       0.000000       0.000000 #>          X50_Y-78..CD4T X53_Y-78..CD4T X52_Y-78..CD4T X50_Y-79..CD4T #> PDK4          0.0000000       0.000000       0.000000      0.0000000 #> TNFRSF17      0.0000000       0.000000       0.000000      0.0000000 #> ICAM3         2.8139101       2.719675       2.002833      2.5727569 #> FAP           0.0000000       0.000000       0.000000      0.0000000 #> GZMB          0.2859526       0.000000       0.000000      0.6173570 #> TSC2          0.0000000       0.000000       0.000000      0.2771736 #>          X53_Y-79..CD4T X49_Y-79..CD4T X52_Y-79..CD4T X54_Y-72..CD4T #> PDK4           0.000000      0.0000000       0.000000              0 #> TNFRSF17       0.000000      0.0000000       0.000000              0 #> ICAM3          2.501836      1.6564799       2.449483              0 #> FAP            0.000000      0.0000000       0.000000              0 #> GZMB           0.275654      0.0000000       0.000000              0 #> TSC2           0.000000      0.2217389       0.000000              0 #>          X52_Y-72..CD4T X51_Y-73..CD4T X51_Y-74..CD4T X44_Y-91..CD4T #> PDK4          0.0000000      0.0000000              0      0.0000000 #> TNFRSF17      0.0000000      0.0000000              0      0.0000000 #> ICAM3         1.9846965      1.2741764              0      2.8864227 #> FAP           0.0000000      0.0000000              0      0.0000000 #> GZMB          0.0000000      0.7058355              0      0.0000000 #> TSC2          0.4529834      0.0000000              0      0.2221676 #>          X46_Y-91..CD4T X48_Y-91..CD4T X47_Y-91..CD4T X45_Y-91..CD4T #> PDK4           0.000000        0.00000       0.000000       0.000000 #> TNFRSF17       0.000000        0.00000       0.000000       0.000000 #> ICAM3          2.985732        1.99598       2.187212       3.577819 #> FAP            0.000000        0.00000       0.000000       0.000000 #> GZMB           0.000000        0.00000       0.000000       0.000000 #> TSC2           0.000000        0.00000       0.000000       0.000000 #>          X43_Y-91..CD4T X43_Y-92..CD4T X45_Y-92..CD4T X47_Y-92..CD4T #> PDK4                  0       0.000000       0.000000      0.0000000 #> TNFRSF17              0       0.000000       0.000000      0.0000000 #> ICAM3                 0       5.141390       3.381131      2.1581818 #> FAP                   0       0.000000       0.000000      0.0000000 #> GZMB                  0       0.000000       0.000000      0.0000000 #> TSC2                  0       1.081453       0.000000      0.4888767 #>          X46_Y-92..CD4T X44_Y-92..CD4T X42_Y-92..CD4T X47_Y-93..CD4T #> PDK4           0.000000       0.000000       0.000000         0.0000 #> TNFRSF17       0.000000       0.000000       0.000000         0.0000 #> ICAM3          2.163602       3.008183       2.851665         2.9947 #> FAP            0.000000       0.000000       0.000000         0.0000 #> GZMB           0.000000       0.000000       0.000000         0.0000 #> TSC2           0.439989       0.000000       0.000000         0.0000 #>          X44_Y-93..CD4T X45_Y-93..CD4T X46_Y-93..CD4T X46_Y-94..CD4T #> PDK4           0.000000       0.000000        0.00000       0.000000 #> TNFRSF17       0.000000       0.000000        0.00000       0.000000 #> ICAM3          2.466472       3.459759        3.07575       2.415677 #> FAP            0.000000       0.000000        0.00000       0.000000 #> GZMB           0.000000       0.000000        0.00000       0.000000 #> TSC2           0.000000       0.000000        0.00000       0.000000 #>          X45_Y-94..CD4T X44_Y-94..CD4T X46_Y-95..CD4T X45_Y-95..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.741632       4.790279       2.449616       2.386433 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X44_Y-95..CD4T X44_Y-96..CD4T X45_Y-96..CD4T X46_Y-96..CD4T #> PDK4           0.000000      0.0000000       0.000000        0.00000 #> TNFRSF17       0.000000      0.0000000       0.000000        0.00000 #> ICAM3          2.309367      2.7275589       1.800479        1.73217 #> FAP            0.000000      0.0000000       0.000000        0.00000 #> GZMB           0.000000      0.6711014       0.469771        0.00000 #> TSC2           0.000000      0.0000000       0.000000        0.00000 #>          X46_Y-97..CD4T X44_Y-97..CD4T X48_Y-92..CD4T X47_Y-97..CD4T #> PDK4           0.000000       0.000000       0.000000              0 #> TNFRSF17       0.000000       0.000000       0.000000              0 #> ICAM3          1.568517       1.680811       1.262893              0 #> FAP            0.000000       0.000000       0.000000              0 #> GZMB           0.000000       0.000000       0.000000              0 #> TSC2           0.000000       0.000000       0.000000              0 #>          X43_Y-98..CD4T X25_Y-74..CD4T X33_Y-70..CD4T X33_Y-71..CD4T #> PDK4           0.000000        0.00000       0.000000              0 #> TNFRSF17       0.000000        0.00000       0.000000              0 #> ICAM3          3.648973        5.84594       4.268613              0 #> FAP            0.000000        0.00000       0.000000              0 #> GZMB           0.000000        0.00000       0.000000              0 #> TSC2           0.000000        0.00000       0.000000              0 #>          X29_Y-72..CD4T X35_Y-82..CD4T X35_Y-81..CD4T X28_Y-80..CD4T #> PDK4           0.000000              0              0       0.000000 #> TNFRSF17       0.000000              0              0       0.000000 #> ICAM3          2.411979              0              0       4.940848 #> FAP            0.000000              0              0       0.000000 #> GZMB           0.000000              0              0       0.000000 #> TSC2           0.000000              0              0       0.000000 #>          X24_Y-83..CD4T X25_Y-68..CD4T X30_Y-68..CD4T X23_Y-79..CD4T #> PDK4           0.000000       0.000000              0       0.000000 #> TNFRSF17       0.000000       0.000000              0       0.000000 #> ICAM3          5.812138       4.378773              0       4.764556 #> FAP            0.000000       0.000000              0       0.000000 #> GZMB           0.000000       0.000000              0       0.000000 #> TSC2           0.000000       0.000000              0       0.000000 #>          X45_Y-66..CD4T X46_Y-66..CD4T X53_Y-64..CD4T X53_Y-65..CD4T #> PDK4           0.000000       0.000000        0.00000       0.000000 #> TNFRSF17       0.000000       0.000000        0.00000       0.000000 #> ICAM3          4.402383       5.681529        2.90065       2.606103 #> FAP            0.000000       0.000000        0.00000       0.000000 #> GZMB           0.000000       0.000000        0.00000       0.000000 #> TSC2           0.000000       0.000000        0.00000       0.000000 #>          X52_Y-65..CD4T X54_Y-65..CD4T X55_Y-65..CD4T X51_Y-65..CD4T #> PDK4           0.000000      0.0000000       0.000000        0.00000 #> TNFRSF17       0.000000      0.0000000       0.000000        0.00000 #> ICAM3          2.392239      2.3838229       2.971039        1.89856 #> FAP            0.000000      0.0000000       0.000000        0.00000 #> GZMB           0.000000      0.3839662       0.000000        0.00000 #> TSC2           0.000000      0.0000000       0.000000        0.00000 #>          X52_Y-66..CD4T X51_Y-66..CD4T X49_Y-66..CD4T X48_Y-66..CD4T #> PDK4          0.0000000       0.000000              0              0 #> TNFRSF17      0.0000000       0.000000              0              0 #> ICAM3         2.9298193       1.437792              0              0 #> FAP           0.0000000       0.000000              0              0 #> GZMB          0.0000000       0.000000              0              0 #> TSC2          0.2606045       0.000000              0              0 #>          X51_Y-67..CD4T X52_Y-67..CD4T X54_Y-64..CD4T X53_Y-66..CD4T #> PDK4          0.0000000      0.0000000      0.0000000       0.000000 #> TNFRSF17      0.0000000      0.0000000      0.0000000       0.000000 #> ICAM3         1.2010792      1.7090820      2.7558473       2.018587 #> FAP           0.0000000      0.0000000      0.0000000       0.000000 #> GZMB          0.8802377      0.8802377      0.4479606       0.000000 #> TSC2          0.0000000      0.0000000      0.0000000       0.000000 #>          X37_Y-82..CD4T X41_Y-83..CD4T X48_Y-73..CD4T X45_Y-73..CD4T #> PDK4                  0       0.000000        0.00000              0 #> TNFRSF17              0       0.000000        0.00000              0 #> ICAM3                 0       5.343928        0.00000              0 #> FAP                   0       0.000000        0.00000              0 #> GZMB                  0       4.655546        4.70854              0 #> TSC2                  0       0.000000        0.00000              0 #>          X47_Y-73..CD4T X46_Y-73..CD4T X47_Y-74..CD4T X43_Y-74..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          4.053026       1.272347       2.472211       4.254824 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X46_Y-74..CD4T X44_Y-74..CD4T X46_Y-75..CD4T X47_Y-75..CD4T #> PDK4           0.000000       0.000000        0.00000       0.000000 #> TNFRSF17       0.000000       0.000000        0.00000       0.000000 #> ICAM3          1.771937       4.954735        0.69184       1.387834 #> FAP            0.000000       0.000000        0.00000       0.000000 #> GZMB           0.000000       0.000000        0.00000       0.000000 #> TSC2           0.000000       0.000000        0.00000       0.000000 #>          X43_Y-75..CD4T X45_Y-75..CD4T X46_Y-76..CD4T X44_Y-76..CD4T #> PDK4           0.000000              0      0.0000000       0.000000 #> TNFRSF17       0.000000              0      0.0000000       0.000000 #> ICAM3          2.370883              0      1.3788880       3.976987 #> FAP            0.000000              0      0.0000000       0.000000 #> GZMB           0.000000              0      0.4990333       0.000000 #> TSC2           2.370883              0      0.0000000       0.000000 #>          X47_Y-76..CD4T X45_Y-77..CD4T X47_Y-77..CD4T X46_Y-77..CD4T #> PDK4          0.0000000        0.00000       0.000000      0.0000000 #> TNFRSF17      0.0000000        0.00000       0.000000      0.0000000 #> ICAM3         1.7798896        3.85601       3.583673      2.8451320 #> FAP           0.0000000        0.00000       0.000000      0.0000000 #> GZMB          0.4536667        0.00000       0.000000      0.0000000 #> TSC2          0.0000000        0.00000       0.000000      0.9774357 #>          X43_Y-77..CD4T X44_Y-78..CD4T X47_Y-78..CD4T X46_Y-78..CD4T #> PDK4           0.000000       0.000000       0.000000      0.0000000 #> TNFRSF17       0.000000       0.000000       0.000000      0.0000000 #> ICAM3          4.243257       4.720328       2.515943      2.9498188 #> FAP            0.000000       0.000000       0.000000      0.0000000 #> GZMB           0.000000       0.000000       0.000000      0.3505727 #> TSC2           0.000000       0.000000       0.000000      0.3759368 #>          X45_Y-78..CD4T X43_Y-78..CD4T X46_Y-79..CD4T X44_Y-79..CD4T #> PDK4           0.000000              0      0.0000000              0 #> TNFRSF17       0.000000              0      0.0000000              0 #> ICAM3          2.933036              0      3.3127721              0 #> FAP            0.000000              0      0.0000000              0 #> GZMB           0.000000              0      0.2278723              0 #> TSC2           0.000000              0      0.0000000              0 #>          X45_Y-79..CD4T X47_Y-79..CD4T X48_Y-79..CD4T X47_Y-72..CD4T #> PDK4          0.0000000       0.000000       0.000000       0.000000 #> TNFRSF17      0.0000000       0.000000       0.000000       0.000000 #> ICAM3         3.1908962       2.050485       1.842319       3.512688 #> FAP           0.0000000       0.000000       0.000000       0.000000 #> GZMB          0.0000000       0.000000       0.000000       0.000000 #> TSC2          0.3477538       0.000000       0.000000       0.000000 #>          X42_Y-76..CD4T X44_Y-77..CD4T X75_Y-80..CD4T X76_Y-80..CD4T #> PDK4           0.000000        0.00000         0.0000       0.000000 #> TNFRSF17       0.000000        0.00000         0.0000       0.000000 #> ICAM3          5.697193        2.19329         2.5279       2.247022 #> FAP            0.000000        0.00000         0.0000       0.000000 #> GZMB           0.000000        0.00000         0.0000       0.000000 #> TSC2           4.605269        0.00000         0.0000       0.000000 #>          X76_Y-81..CD4T X77_Y-81..CD4T X75_Y-81..CD4T X78_Y-82..CD4T #> PDK4          0.0000000      0.0000000       0.000000       0.000000 #> TNFRSF17      0.0000000      0.0000000       0.000000       0.000000 #> ICAM3         1.9651102      2.1705557       3.532326       4.099151 #> FAP           0.0000000      0.0000000       0.000000       0.000000 #> GZMB          0.0000000      0.5601438       0.000000       0.000000 #> TSC2          0.6158943      0.0000000       1.231789       0.000000 #>          X76_Y-82..CD4T X77_Y-82..CD4T X78_Y-83..CD4T X77_Y-83..CD4T #> PDK4           0.000000       0.000000       0.000000        0.00000 #> TNFRSF17       0.000000       0.000000       0.000000        0.00000 #> ICAM3          2.723407       2.794452       1.989258        1.77721 #> FAP            0.000000       0.000000       0.000000        0.00000 #> GZMB           0.000000       0.000000       0.000000        0.00000 #> TSC2           0.000000       0.000000       0.000000        0.00000 #>          X78_Y-84..CD4T X78_Y-81..CD4T X79_Y-83..CD4T X79_Y-84..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          1.727245       3.972802       2.486573       1.989258 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X74_Y-66..CD4T X72_Y-66..CD4T X74_Y-67..CD4T X76_Y-67..CD4T #> PDK4          0.0000000      0.0000000      0.0000000              0 #> TNFRSF17      0.0000000      0.0000000      0.0000000              0 #> ICAM3         2.9681365      2.3115971      2.7792518              0 #> FAP           0.0000000      0.0000000      0.0000000              0 #> GZMB          0.0000000      0.0000000      0.4755478              0 #> TSC2          0.6045352      0.3211678      0.0000000              0 #>          X75_Y-67..CD4T X78_Y-67..CD4T X74_Y-68..CD4T X76_Y-68..CD4T #> PDK4          0.0000000              0      0.0000000       0.000000 #> TNFRSF17      0.0000000              0      0.0000000       0.000000 #> ICAM3         2.5835230              0      2.9288163       1.027737 #> FAP           0.0000000              0      0.0000000       0.000000 #> GZMB          0.5858747              0      0.2189387       0.000000 #> TSC2          0.0000000              0      0.2376547       0.000000 #>          X77_Y-68..CD4T X75_Y-68..CD4T X78_Y-68..CD4T X74_Y-69..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          4.002422       2.187484       4.817691       2.678261 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X75_Y-69..CD4T X76_Y-69..CD4T X78_Y-69..CD4T X77_Y-69..CD4T #> PDK4          0.0000000      0.0000000              0       0.000000 #> TNFRSF17      0.0000000      0.0000000              0       0.000000 #> ICAM3         2.5489807      2.4360164              0       1.433086 #> FAP           0.0000000      0.0000000              0       0.000000 #> GZMB          0.3318059      0.0000000              0       0.000000 #> TSC2          0.0000000      0.4311194              0       0.000000 #>          X77_Y-70..CD4T X74_Y-70..CD4T X76_Y-70..CD4T X75_Y-70..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          1.675755       3.220413       2.695886       2.369243 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X74_Y-71..CD4T X78_Y-71..CD4T X74_Y-72..CD4T X78_Y-72..CD4T #> PDK4          0.0000000       0.000000      0.0000000       0.000000 #> TNFRSF17      0.0000000       0.000000      0.0000000       0.000000 #> ICAM3         2.5402445       2.388077      3.3137032       1.194038 #> FAP           0.0000000       0.000000      0.0000000       0.000000 #> GZMB          0.4887265       0.000000      0.8948206       0.000000 #> TSC2          0.0000000       0.000000      0.0000000       0.000000 #>          X76_Y-72..CD4T X74_Y-73..CD4T X56_Y-66..CD4T X58_Y-66..CD4T #> PDK4                  0       0.000000       0.000000      0.0000000 #> TNFRSF17              0       0.000000       0.000000      0.0000000 #> ICAM3                 0       2.611758       2.922171      3.9124797 #> FAP                   0       0.000000       0.000000      0.0000000 #> GZMB                  0       0.000000       0.000000      0.9506189 #> TSC2                  0       1.140373       0.000000      0.0000000 #>          X56_Y-67..CD4T X59_Y-67..CD4T X57_Y-67..CD4T X60_Y-67..CD4T #> PDK4           0.000000       0.000000      0.0000000       0.000000 #> TNFRSF17       0.000000       0.000000      0.0000000       0.000000 #> ICAM3          4.654690       1.516052      4.1885277       1.096645 #> FAP            0.000000       0.000000      0.0000000       0.000000 #> GZMB           0.000000       1.584365      0.0000000       1.153780 #> TSC2           1.483796       1.516052      0.8902773       0.000000 #>          X59_Y-68..CD4T X60_Y-68..CD4T X58_Y-68..CD4T X58_Y-69..CD4T #> PDK4                  0      0.0000000              0              0 #> TNFRSF17              0      0.0000000              0              0 #> ICAM3                 0      1.7562058              0              0 #> FAP                   0      0.0000000              0              0 #> GZMB                  0      0.9230241              0              0 #> TSC2                  0      0.0000000              0              0 #>          X57_Y-70..CD4T X60_Y-70..CD4T X57_Y-66..CD4T X58_Y-67..CD4T #> PDK4           0.000000       0.000000        0.00000       0.000000 #> TNFRSF17       0.000000       0.000000        0.00000       0.000000 #> ICAM3          4.040696       4.999905        3.58642       2.216657 #> FAP            0.000000       0.000000        0.00000       0.000000 #> GZMB           0.000000       0.000000        0.00000       1.188274 #> TSC2           0.000000       2.661704        0.00000       1.137039 #>          X55_Y-68..CD4T X59_Y-69..CD4T X48_Y-80..CD4T X45_Y-80..CD4T #> PDK4                  0       0.000000      0.0000000      0.0000000 #> TNFRSF17              0       0.000000      0.0000000      0.0000000 #> ICAM3                 0       3.017342      2.4498545      2.3347666 #> FAP                   0       0.000000      0.0000000      0.0000000 #> GZMB                  0       0.000000      0.0000000      0.0000000 #> TSC2                  0       0.000000      0.3745158      0.3477538 #>          X46_Y-80..CD4T X47_Y-80..CD4T X44_Y-80..CD4T X43_Y-80..CD4T #> PDK4           0.000000        0.00000       0.000000       0.000000 #> TNFRSF17       0.000000        0.00000       0.000000       0.000000 #> ICAM3          2.026973        2.06113       3.022048       2.498805 #> FAP            0.000000        0.00000       0.000000       0.000000 #> GZMB           0.000000        0.00000       0.000000       0.000000 #> TSC2           0.000000        0.00000       0.000000       0.000000 #>          X44_Y-81..CD4T X45_Y-81..CD4T X46_Y-81..CD4T X47_Y-81..CD4T #> PDK4           0.000000       0.000000      0.0000000       0.000000 #> TNFRSF17       0.000000       0.000000      0.0000000       0.000000 #> ICAM3          3.243220       2.122589      3.2304350       3.361997 #> FAP            0.000000       0.000000      0.0000000       0.000000 #> GZMB           0.463297       0.000000      0.3729817       0.000000 #> TSC2           0.000000       0.000000      0.3305225       0.000000 #>          X46_Y-82..CD4T X45_Y-82..CD4T X44_Y-82..CD4T X47_Y-82..CD4T #> PDK4          0.0000000       0.000000       0.000000       0.000000 #> TNFRSF17      0.0000000       0.000000       0.000000       0.000000 #> ICAM3         2.6213040       1.861670       1.302123       2.196719 #> FAP           0.0000000       0.000000       0.000000       0.000000 #> GZMB          0.5975719       0.000000       0.000000       0.689506 #> TSC2          0.0000000       0.372357       1.117071       0.000000 #>          X44_Y-83..CD4T X45_Y-83..CD4T X43_Y-83..CD4T X46_Y-83..CD4T #> PDK4           0.000000      0.0000000              0      0.0000000 #> TNFRSF17       0.000000      0.0000000              0      0.0000000 #> ICAM3          2.342666      2.7795192              0      3.0657195 #> FAP            0.000000      0.0000000              0      0.0000000 #> GZMB           0.000000      0.0000000              0      0.0000000 #> TSC2           0.000000      0.4855019              0      0.4315573 #>          X44_Y-84..CD4T X43_Y-84..CD4T X44_Y-85..CD4T X43_Y-85..CD4T #> PDK4           0.000000      0.0000000      0.0000000      0.0000000 #> TNFRSF17       0.000000      0.0000000      0.0000000      0.0000000 #> ICAM3          3.675083      3.1547966      2.2859938      3.1308372 #> FAP            0.000000      0.0000000      0.0000000      0.0000000 #> GZMB           0.000000      0.0000000      0.0000000      0.0000000 #> TSC2           0.000000      0.3095145      0.3403699      0.2280633 #>          X42_Y-85..CD4T X43_Y-81..CD4T X43_Y-82..CD4T X51_Y-91..CD4T #> PDK4           0.000000       0.000000       0.000000      0.0000000 #> TNFRSF17       0.000000       0.000000       0.000000      0.0000000 #> ICAM3          3.970494       5.027264       2.513632      0.9342106 #> FAP            0.000000       0.000000       0.000000      0.0000000 #> GZMB           0.000000       0.000000       0.000000      0.0000000 #> TSC2           0.000000       0.000000       0.000000      0.0000000 #>          X49_Y-91..CD4T X53_Y-92..CD4T X51_Y-92..CD4T X54_Y-92..CD4T #> PDK4           0.000000       0.000000       0.000000              0 #> TNFRSF17       0.000000       0.000000       0.000000              0 #> ICAM3          2.041831       1.547737       1.584365              0 #> FAP            0.000000       0.000000       0.000000              0 #> GZMB           0.000000       0.000000       0.000000              0 #> TSC2           0.000000       0.000000       0.000000              0 #>          X53_Y-93..CD4T X49_Y-93..CD4T X51_Y-94..CD4T X51_Y-96..CD4T #> PDK4           0.000000         0.0000              0       0.000000 #> TNFRSF17       0.000000         0.0000              0       0.000000 #> ICAM3          2.112783         1.7443              0       4.577379 #> FAP            0.000000         0.0000              0       0.000000 #> GZMB           0.000000         0.0000              0       2.159238 #> TSC2           0.000000         0.0000              0       0.000000 #>          X50_Y-91..CD4T X50_Y-92..CD4T X52_Y-92..CD4T X49_Y-92..CD4T #> PDK4           0.000000       0.000000       0.000000         0.0000 #> TNFRSF17       0.000000       0.000000       0.000000         0.0000 #> ICAM3          1.318517       0.000000       2.373715         1.7443 #> FAP            0.000000       0.000000       0.000000         0.0000 #> GZMB           0.000000       0.000000       0.000000         0.0000 #> TSC2           0.445484       1.696173       0.000000         0.0000 #>          X52_Y-96..CD4T X72_Y-79..CD4T X71_Y-80..CD4T X70_Y-80..CD4T #> PDK4           0.000000       0.000000       0.000000      0.0000000 #> TNFRSF17       0.000000       0.000000       0.000000      0.0000000 #> ICAM3          4.577379       2.782646       3.260614      2.8330046 #> FAP            0.000000       0.000000       0.000000      0.0000000 #> GZMB           2.159238       0.000000       0.000000      0.3229489 #> TSC2           0.000000       0.000000       0.000000      0.0000000 #>          X71_Y-81..CD4T X71_Y-82..CD4T X72_Y-82..CD4T X70_Y-82..CD4T #> PDK4            0.00000       0.000000       0.000000       0.000000 #> TNFRSF17        0.00000       0.000000       0.000000       0.000000 #> ICAM3           2.48785       2.544154       3.382456       2.556642 #> FAP             0.00000       0.000000       0.000000       0.000000 #> GZMB            0.00000       0.000000       0.000000       0.000000 #> TSC2            0.00000       0.000000       0.000000       0.000000 #>          X71_Y-83..CD4T X70_Y-83..CD4T X70_Y-84..CD4T X69_Y-84..CD4T #> PDK4          0.0000000      0.0000000      0.0000000      0.0000000 #> TNFRSF17      0.0000000      0.0000000      0.0000000      0.0000000 #> ICAM3         2.8190836      4.0227149      3.7805610      2.8066028 #> FAP           0.0000000      0.0000000      0.0000000      0.0000000 #> GZMB          0.0000000      0.0000000      0.1912612      0.4205541 #> TSC2          0.5732323      0.3275613      0.0000000      0.0000000 #>          X66_Y-84..CD4T X68_Y-84..CD4T X71_Y-84..CD4T X67_Y-84..CD4T #> PDK4           0.000000      0.0000000       0.000000      0.0000000 #> TNFRSF17       0.000000      0.0000000       0.000000      0.0000000 #> ICAM3          2.579774      3.2852575       4.023536      2.7081877 #> FAP            0.000000      0.0000000       0.000000      0.0000000 #> GZMB           0.000000      0.6980842       0.000000      0.4766301 #> TSC2           0.000000      0.2322641       0.000000      0.0000000 #>          X68_Y-85..CD4T X69_Y-85..CD4T X70_Y-85..CD4T X67_Y-85..CD4T #> PDK4          0.0000000      0.0000000       0.000000      0.0000000 #> TNFRSF17      0.0000000      0.0000000       0.000000      0.0000000 #> ICAM3         3.1814777      2.7630776       2.748494      2.3801721 #> FAP           0.0000000      0.0000000       0.000000      0.0000000 #> GZMB          0.6681477      0.2292929       0.000000      0.6619542 #> TSC2          0.4478238      0.0000000       0.000000      0.4750883 #>          X68_Y-79..CD4T X50_Y-67..CD4T X48_Y-67..CD4T X51_Y-68..CD4T #> PDK4           0.000000       0.000000       0.000000      0.0000000 #> TNFRSF17       0.000000       0.000000       0.000000      0.0000000 #> ICAM3          4.275582       2.417919       4.132759      3.3378203 #> FAP            0.000000       0.000000       0.000000      0.0000000 #> GZMB           0.000000       0.000000       0.000000      0.0000000 #> TSC2           0.000000       0.000000       0.000000      0.2242739 #>          X52_Y-68..CD4T X50_Y-68..CD4T X49_Y-68..CD4T X48_Y-68..CD4T #> PDK4          0.0000000         0.0000      0.0000000       0.000000 #> TNFRSF17      0.0000000         0.0000      0.0000000       0.000000 #> ICAM3         2.4493445         1.7684      0.8019646       4.626021 #> FAP           0.0000000         0.0000      0.0000000       0.000000 #> GZMB          0.4548155         0.0000      0.7675449       0.000000 #> TSC2          0.0000000         0.0000      0.0000000       0.000000 #>          X51_Y-69..CD4T X49_Y-69..CD4T X50_Y-69..CD4T X52_Y-69..CD4T #> PDK4          0.0000000       0.000000      0.0000000       0.000000 #> TNFRSF17      0.0000000       0.000000      0.0000000       0.000000 #> ICAM3         2.6955067       2.413745      1.1322411       3.862567 #> FAP           0.0000000       0.000000      0.0000000       0.000000 #> GZMB          0.0000000       1.410509      0.5502978       0.000000 #> TSC2          0.2274077       0.000000      0.0000000       0.000000 #>          X48_Y-69..CD4T X51_Y-70..CD4T X49_Y-70..CD4T X52_Y-70..CD4T #> PDK4           0.000000      0.0000000       0.000000      0.0000000 #> TNFRSF17       0.000000      0.0000000       0.000000      0.0000000 #> ICAM3          4.626021      3.4586830       2.359365      3.2520373 #> FAP            0.000000      0.0000000       0.000000      0.0000000 #> GZMB           0.000000      0.2449072       1.082892      0.3469518 #> TSC2           0.000000      0.0000000       0.000000      0.0000000 #>          X48_Y-70..CD4T X51_Y-71..CD4T X52_Y-71..CD4T X48_Y-72..CD4T #> PDK4            0.00000       0.000000       0.000000              0 #> TNFRSF17        0.00000       0.000000       0.000000              0 #> ICAM3           2.94201       1.908959       2.129468              0 #> FAP             0.00000       0.000000       0.000000              0 #> GZMB            0.00000       0.000000       0.000000              0 #> TSC2            0.00000       0.000000       0.000000              0 #>          X65_Y-65..CD4T X57_Y-80..CD4T X54_Y-80..CD4T X56_Y-80..CD4T #> PDK4                  0       0.000000      0.0000000        0.00000 #> TNFRSF17              0       0.000000      0.0000000        0.00000 #> ICAM3                 0       1.790643      2.2859167        2.21147 #> FAP                   0       0.000000      0.0000000        0.00000 #> GZMB                  0       0.000000      0.7873398        0.00000 #> TSC2                  0       0.000000      0.0000000        0.00000 #>          X55_Y-80..CD4T X59_Y-80..CD4T X58_Y-80..CD4T X55_Y-81..CD4T #> PDK4          0.0000000       0.000000       0.000000       0.000000 #> TNFRSF17      0.0000000       0.000000       0.000000       0.000000 #> ICAM3         1.6617296       0.000000       1.235212       2.272359 #> FAP           0.0000000       0.000000       0.000000       0.000000 #> GZMB          0.4030235       2.889724       1.444862       0.000000 #> TSC2          0.0000000       0.000000       0.000000       0.000000 #>          X57_Y-81..CD4T X58_Y-81..CD4T X56_Y-81..CD4T X54_Y-81..CD4T #> PDK4           0.000000        0.00000       0.000000       0.000000 #> TNFRSF17       0.000000        0.00000       0.000000       0.000000 #> ICAM3          1.786985        2.58012       2.932332       1.421813 #> FAP            0.000000        0.00000       0.000000       0.000000 #> GZMB           0.000000        0.00000       0.000000       0.000000 #> TSC2           0.000000        0.00000       0.000000       0.000000 #>          X59_Y-81..CD4T X60_Y-81..CD4T X58_Y-82..CD4T X55_Y-82..CD4T #> PDK4           0.000000      0.0000000       0.000000       0.000000 #> TNFRSF17       0.000000      0.0000000       0.000000       0.000000 #> ICAM3          2.195498      0.7979814       1.836735       1.439938 #> FAP            0.000000      0.0000000       0.000000       0.000000 #> GZMB           0.000000      0.0000000       0.000000       0.000000 #> TSC2           0.000000      0.0000000       0.000000       0.000000 #>          X57_Y-82..CD4T X56_Y-82..CD4T X59_Y-82..CD4T X54_Y-82..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          1.774773       1.125956       1.340412       2.412132 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X57_Y-83..CD4T X59_Y-83..CD4T X58_Y-83..CD4T X55_Y-83..CD4T #> PDK4           0.000000              0       0.000000       0.000000 #> TNFRSF17       0.000000              0       0.000000       0.000000 #> ICAM3          1.942505              0       3.591599       3.018908 #> FAP            0.000000              0       0.000000       0.000000 #> GZMB           0.000000              0       0.000000       0.000000 #> TSC2           0.000000              0       0.000000       0.000000 #>          X61_Y-83..CD4T X56_Y-83..CD4T X58_Y-84..CD4T X57_Y-84..CD4T #> PDK4           0.000000              0        0.00000      0.0000000 #> TNFRSF17       0.000000              0        0.00000      0.0000000 #> ICAM3          1.754761              0        2.23795      1.8088659 #> FAP            0.000000              0        0.00000      0.0000000 #> GZMB           0.000000              0        0.00000      0.9672564 #> TSC2           0.000000              0        0.00000      0.0000000 #>          X59_Y-84..CD4T X54_Y-84..CD4T X55_Y-84..CD4T X59_Y-85..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          4.142667       4.315649       4.416319       2.091148 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X60_Y-85..CD4T X56_Y-85..CD4T X61_Y-85..CD4T X56_Y-84..CD4T #> PDK4          0.0000000       0.000000       0.000000              0 #> TNFRSF17      0.0000000       0.000000       0.000000              0 #> ICAM3         1.7870027       4.566825       1.754484              0 #> FAP           0.0000000       0.000000       0.000000              0 #> GZMB          0.5732323       0.000000       0.000000              0 #> TSC2          0.0000000       0.000000       0.000000              0 #>          X79_Y-80..CD4T X60_Y-82..CD4T X60_Y-83..CD4T X62_Y-83..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          4.468283       1.584365       1.754761       2.453962 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           4.468283       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X64_Y-84..CD4T X62_Y-84..CD4T X63_Y-84..CD4T X61_Y-84..CD4T #> PDK4          0.0000000       0.000000       0.000000              0 #> TNFRSF17      0.0000000       0.000000       0.000000              0 #> ICAM3         2.6643191       2.102488       2.680496              0 #> FAP           0.0000000       0.000000       0.000000              0 #> GZMB          0.0000000       0.000000       0.000000              0 #> TSC2          0.2671964       0.000000       0.000000              0 #>          X65_Y-84..CD4T X62_Y-85..CD4T X64_Y-85..CD4T X63_Y-85..CD4T #> PDK4          0.0000000      0.0000000       0.000000      0.0000000 #> TNFRSF17      0.0000000      0.0000000       0.000000      0.0000000 #> ICAM3         1.6649262      1.8305633       2.710257      3.0156406 #> FAP           0.0000000      0.0000000       0.000000      0.0000000 #> GZMB          0.2513632      0.9378541       0.000000      0.2732539 #> TSC2          0.0000000      0.0000000       0.000000      0.0000000 #>          X65_Y-85..CD4T X61_Y-80..CD4T X64_Y-83..CD4T X66_Y-85..CD4T #> PDK4          0.0000000              0       0.000000      0.0000000 #> TNFRSF17      0.0000000              0       0.000000      0.0000000 #> ICAM3         1.6595285              0       3.616574      2.4627101 #> FAP           0.0000000              0       0.000000      0.0000000 #> GZMB          0.2513632              0       0.000000      0.2659938 #> TSC2          0.0000000              0       0.000000      0.0000000 #>          X34_Y-91..CD4T X35_Y-91..CD4T X35_Y-93..CD4T X36_Y-94..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          4.703852       1.449386       2.443589       1.745331 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X36_Y-95..CD4T X34_Y-96..CD4T X34_Y-97..CD4T X36_Y-92..CD4T #> PDK4           0.000000       0.000000       0.000000              0 #> TNFRSF17       0.000000       0.000000       0.000000              0 #> ICAM3          4.954735       3.804965       0.000000              0 #> FAP            0.000000       0.000000       0.000000              0 #> GZMB           0.000000       0.000000       4.296792              0 #> TSC2           0.000000       0.000000       0.000000              0 #>          X35_Y-92..CD4T X35_Y-94..CD4T X34_Y-95..CD4T X35_Y-96..CD4T #> PDK4           0.000000              0        0.00000          0.000 #> TNFRSF17       0.000000              0        0.00000          0.000 #> ICAM3          1.449386              0        5.03209          5.011 #> FAP            0.000000              0        0.00000          0.000 #> GZMB           0.000000              0        0.00000          0.000 #> TSC2           0.000000              0        0.00000          0.000 #>          X48_Y-85..CD4T X42_Y-86..CD4T X44_Y-86..CD4T X45_Y-86..CD4T #> PDK4           0.000000       0.000000       0.000000      0.0000000 #> TNFRSF17       0.000000       0.000000       0.000000      0.0000000 #> ICAM3          3.209201       1.434655       2.140443      2.6436466 #> FAP            0.000000       0.000000       0.000000      0.0000000 #> GZMB           0.000000       0.000000       0.000000      0.0000000 #> TSC2           0.000000       0.000000       0.463297      0.4641407 #>          X45_Y-87..CD4T X44_Y-87..CD4T X42_Y-87..CD4T X47_Y-87..CD4T #> PDK4          0.0000000      0.0000000       0.000000      0.0000000 #> TNFRSF17      0.0000000      0.0000000       0.000000      0.0000000 #> ICAM3         2.6593864      4.8167270       2.388077      1.8179846 #> FAP           0.0000000      0.0000000       0.000000      0.0000000 #> GZMB          0.0000000      0.0000000       0.000000      0.0000000 #> TSC2          0.5346431      0.9623575       0.000000      0.8289816 #>          X46_Y-87..CD4T X42_Y-88..CD4T X45_Y-88..CD4T X46_Y-88..CD4T #> PDK4          0.0000000       0.000000       0.000000      0.0000000 #> TNFRSF17      0.0000000       0.000000       0.000000      0.0000000 #> ICAM3         1.8149937       4.918402       1.121785      2.7419189 #> FAP           0.0000000       0.000000       0.000000      0.0000000 #> GZMB          0.8666407       0.000000       0.000000      0.3611003 #> TSC2          0.0000000       0.000000       0.000000      0.0000000 #>          X44_Y-88..CD4T X47_Y-88..CD4T X43_Y-88..CD4T X45_Y-89..CD4T #> PDK4           0.000000       0.000000       0.000000      0.0000000 #> TNFRSF17       0.000000       0.000000       0.000000      0.0000000 #> ICAM3          3.807113       2.173297       4.635125      2.6109039 #> FAP            0.000000       0.000000       0.000000      0.0000000 #> GZMB           0.000000       0.000000       0.000000      0.2519177 #> TSC2           0.000000       0.000000       0.000000      0.2519177 #>          X44_Y-89..CD4T X47_Y-89..CD4T X48_Y-89..CD4T X46_Y-89..CD4T #> PDK4           0.000000      0.0000000      0.0000000      0.0000000 #> TNFRSF17       0.000000      0.0000000      0.0000000      0.0000000 #> ICAM3          3.544828      1.6576712      2.3091069      2.1872385 #> FAP            0.000000      0.0000000      0.0000000      0.0000000 #> GZMB           0.000000      0.0000000      0.0000000      0.2009494 #> TSC2           0.000000      0.1946694      0.6432827      0.0000000 #>          X47_Y-90..CD4T X44_Y-90..CD4T X46_Y-90..CD4T X48_Y-90..CD4T #> PDK4          0.0000000       0.000000      0.0000000      0.0000000 #> TNFRSF17      0.0000000       0.000000      0.0000000      0.0000000 #> ICAM3         2.1259014       2.409164      2.0598530      2.8546606 #> FAP           0.0000000       0.000000      0.0000000      0.0000000 #> GZMB          0.2511868       0.000000      0.2232772      0.0000000 #> TSC2          0.2433368       0.000000      0.2165617      0.4093617 #>          X43_Y-90..CD4T X45_Y-90..CD4T X42_Y-90..CD4T X42_Y-91..CD4T #> PDK4           0.000000      0.0000000       0.000000       0.000000 #> TNFRSF17       0.000000      0.0000000       0.000000       0.000000 #> ICAM3          3.436736      2.6941335       3.139337       4.108909 #> FAP            0.000000      0.0000000       0.000000       0.000000 #> GZMB           0.000000      0.2141300       0.000000       0.000000 #> TSC2           0.000000      0.4090356       0.000000       0.000000 #>          X45_Y-85..CD4T X48_Y-86..CD4T X43_Y-86..CD4T X51_Y-79..CD4T #> PDK4           0.000000       0.000000       0.000000      0.0000000 #> TNFRSF17       0.000000       0.000000       0.000000      0.0000000 #> ICAM3          3.544599       3.595174       3.495159      2.2785529 #> FAP            0.000000       0.000000       0.000000      0.0000000 #> GZMB           0.000000       0.000000       0.000000      0.6027839 #> TSC2           0.729364       0.000000       1.389891      0.2883874 #>          X53_Y-80..CD4T X51_Y-80..CD4T X52_Y-80..CD4T X49_Y-80..CD4T #> PDK4           0.000000      0.0000000       0.000000      0.0000000 #> TNFRSF17       0.000000      0.0000000       0.000000      0.0000000 #> ICAM3          2.508922      3.3834226       3.310062      2.8229007 #> FAP            0.000000      0.0000000       0.000000      0.0000000 #> GZMB           0.000000      0.2694496       0.000000      0.0000000 #> TSC2           0.000000      0.2703632       0.000000      0.2370883 #>          X50_Y-80..CD4T X50_Y-81..CD4T X53_Y-81..CD4T X51_Y-81..CD4T #> PDK4          0.0000000       0.000000       0.000000       0.000000 #> TNFRSF17      0.0000000       0.000000       0.000000       0.000000 #> ICAM3         2.4216931       3.415864       2.703015       1.973869 #> FAP           0.0000000       0.000000       0.000000       0.000000 #> GZMB          0.4754153       0.000000       0.000000       0.000000 #> TSC2          0.2370883       0.000000       0.000000       0.000000 #>          X52_Y-81..CD4T X51_Y-82..CD4T X50_Y-82..CD4T X51_Y-83..CD4T #> PDK4           0.000000       0.000000      0.0000000       0.000000 #> TNFRSF17       0.000000       0.000000      0.0000000       0.000000 #> ICAM3          2.766248       1.012956      0.5628724       1.439154 #> FAP            0.000000       0.000000      0.0000000       0.000000 #> GZMB           0.000000       0.000000      0.0000000       0.000000 #> TSC2           0.000000       0.000000      0.0000000       0.000000 #>          X52_Y-83..CD4T X54_Y-83..CD4T X52_Y-84..CD4T X54_Y-85..CD4T #> PDK4          0.0000000        0.00000      0.0000000       0.000000 #> TNFRSF17      0.0000000        0.00000      0.0000000       0.000000 #> ICAM3         3.3682339        3.25856      3.8125185       3.396151 #> FAP           0.0000000        0.00000      0.0000000       0.000000 #> GZMB          0.5387513        0.00000      0.0000000       0.000000 #> TSC2          0.0000000        0.00000      0.7140395       0.000000 #>          X52_Y-85..CD4T X53_Y-82..CD4T X51_Y-84..CD4T X48_Y-84..CD4T #> PDK4           0.000000       0.000000      0.0000000       0.000000 #> TNFRSF17       0.000000       0.000000      0.0000000       0.000000 #> ICAM3          2.580749       2.429512      1.8211110       5.184671 #> FAP            0.000000       0.000000      0.0000000       0.000000 #> GZMB           0.000000       0.000000      0.0000000       0.000000 #> TSC2           0.000000       0.000000      0.5858747       0.000000 #>          X70_Y-91..CD4T X69_Y-92..CD4T X73_Y-93..CD4T X68_Y-94..CD4T #> PDK4                  0       0.000000       0.000000              0 #> TNFRSF17              0       0.000000       0.000000              0 #> ICAM3                 0       5.283602       5.346428              0 #> FAP                   0       0.000000       0.000000              0 #> GZMB                  0       5.283602       0.000000              0 #> TSC2                  0       0.000000       0.000000              0 #>          X66_Y-96..CD4T X73_Y-97..CD4T X70_Y-92..CD4T X69_Y-94..CD4T #> PDK4           0.000000              0       0.000000       0.000000 #> TNFRSF17       0.000000              0       0.000000       0.000000 #> ICAM3          4.686998              0       2.544693       0.000000 #> FAP            0.000000              0       0.000000       0.000000 #> GZMB           0.000000              0       0.000000       5.264283 #> TSC2           0.000000              0       0.000000       0.000000 #>          X78_Y-92..CD4T X76_Y-92..CD4T X76_Y-93..CD4T X75_Y-93..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          4.968234       4.517478       4.669328       4.867351 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X77_Y-93..CD4T X78_Y-94..CD4T X77_Y-94..CD4T X76_Y-94..CD4T #> PDK4           0.000000              0       0.000000        0.00000 #> TNFRSF17       0.000000              0       0.000000        0.00000 #> ICAM3          4.889067              0       2.414025        2.31714 #> FAP            0.000000              0       0.000000        0.00000 #> GZMB           0.000000              0       0.000000        0.00000 #> TSC2           0.000000              0       0.000000        0.00000 #>          X75_Y-94..CD4T X78_Y-95..CD4T X72_Y-95..CD4T X77_Y-95..CD4T #> PDK4           0.000000       0.000000              0       0.000000 #> TNFRSF17       0.000000       0.000000              0       0.000000 #> ICAM3          3.931826       1.789709              0       2.950113 #> FAP            0.000000       0.000000              0       0.000000 #> GZMB           0.000000       0.000000              0       0.000000 #> TSC2           0.000000       0.000000              0       0.000000 #>          X76_Y-95..CD4T X78_Y-96..CD4T X75_Y-96..CD4T X76_Y-96..CD4T #> PDK4                  0        0.00000       0.000000       0.000000 #> TNFRSF17              0        0.00000       0.000000       0.000000 #> ICAM3                 0        4.76277       5.027264       2.348855 #> FAP                   0        0.00000       0.000000       0.000000 #> GZMB                  0        0.00000       5.027264       0.000000 #> TSC2                  0        0.00000       0.000000       0.000000 #>          X78_Y-97..CD4T X75_Y-97..CD4T X74_Y-93..CD4T X74_Y-95..CD4T #> PDK4           0.000000       0.000000       0.000000              0 #> TNFRSF17       0.000000       0.000000       0.000000              0 #> ICAM3          4.912057       4.647939       4.973788              0 #> FAP            0.000000       0.000000       0.000000              0 #> GZMB           0.000000       2.513632       0.000000              0 #> TSC2           0.000000       0.000000       0.000000              0 #>          X73_Y-95..CD4T X42_Y-67..CD4T X46_Y-67..CD4T X46_Y-68..CD4T #> PDK4                  0              0       0.000000       0.000000 #> TNFRSF17              0              0       0.000000       0.000000 #> ICAM3                 0              0       2.783545       3.151365 #> FAP                   0              0       0.000000       0.000000 #> GZMB                  0              0       0.000000       0.000000 #> TSC2                  0              0       0.000000       0.000000 #>          X47_Y-69..CD4T X47_Y-70..CD4T X44_Y-70..CD4T X47_Y-71..CD4T #> PDK4                  0      0.0000000              0        0.00000 #> TNFRSF17              0      0.0000000              0        0.00000 #> ICAM3                 0      0.8788898              0        1.34122 #> FAP                   0      0.0000000              0        0.00000 #> GZMB                  0      0.0000000              0        0.00000 #> TSC2                  0      0.0000000              0        0.00000 #>          X46_Y-71..CD4T X46_Y-69..CD4T X73_Y-65..CD4T X79_Y-65..CD4T #> PDK4           0.000000       0.000000       0.000000              0 #> TNFRSF17       0.000000       0.000000       0.000000              0 #> ICAM3          2.682441       2.127412       2.520053              0 #> FAP            0.000000       0.000000       0.000000              0 #> GZMB           0.000000       0.000000       0.000000              0 #> TSC2           0.000000       0.000000       0.000000              0 #>          X74_Y-65..CD4T X75_Y-66..CD4T X26_Y-89..CD4T X27_Y-90..CD4T #> PDK4           0.000000      0.0000000        0.00000       0.000000 #> TNFRSF17       0.000000      0.0000000        0.00000       0.000000 #> ICAM3          2.183745      2.6855557        3.94168       3.208036 #> FAP            0.000000      0.0000000        0.00000       0.000000 #> GZMB           0.000000      0.5207775        0.00000       0.000000 #> TSC2           0.000000      0.0000000        0.00000       0.000000 #>          X35_Y-86..CD4T X36_Y-88..CD4T X34_Y-90..CD4T X33_Y-91..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          4.050084       4.843472       2.996526       3.400714 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X34_Y-86..CD4T X41_Y-85..CD4T X41_Y-88..CD4T X35_Y-88..CD4T #> PDK4                  0              0       0.000000       0.000000 #> TNFRSF17              0              0       0.000000       0.000000 #> ICAM3                 0              0       4.268613       4.843472 #> FAP                   0              0       0.000000       0.000000 #> GZMB                  0              0       0.000000       0.000000 #> TSC2                  0              0       0.000000       0.000000 #>          X36_Y-89..CD4T X42_Y-89..CD4T X37_Y-90..CD4T X36_Y-90..CD4T #> PDK4                  0        0.00000       0.000000       0.000000 #> TNFRSF17              0        0.00000       0.000000       0.000000 #> ICAM3                 0        3.60346       4.214594       4.374893 #> FAP                   0        0.00000       0.000000       0.000000 #> GZMB                  0        0.00000       0.000000       0.000000 #> TSC2                  0        0.00000       0.000000       0.000000 #>          X32_Y-100..CD4T X30_Y-101..CD4T X31_Y-101..CD4T X30_Y-102..CD4T #> PDK4                   0        0.000000        0.000000        0.000000 #> TNFRSF17               0        0.000000        0.000000        0.000000 #> ICAM3                  0        3.958885        3.721509        3.906175 #> FAP                    0        0.000000        0.000000        0.000000 #> GZMB                   0        0.000000        0.000000        0.000000 #> TSC2                   0        0.000000        0.000000        0.000000 #>          X31_Y-102..CD4T X30_Y-103..CD4T X31_Y-103..CD4T X33_Y-103..CD4T #> PDK4              0.0000        0.000000        0.000000        0.000000 #> TNFRSF17          0.0000        0.000000        0.000000        0.000000 #> ICAM3             3.0761        2.923697        3.491006        2.916626 #> FAP               0.0000        0.000000        0.000000        0.000000 #> GZMB              0.0000        0.000000        0.000000        0.000000 #> TSC2              0.0000        0.000000        0.000000        0.000000 #>          X32_Y-103..CD4T X34_Y-100..CD4T X32_Y-104..CD4T X22_Y-87..CD4T #> PDK4            0.000000               0        0.000000              0 #> TNFRSF17        0.000000               0        0.000000              0 #> ICAM3           3.496819               0        3.193353              0 #> FAP             0.000000               0        0.000000              0 #> GZMB            0.000000               0        0.000000              0 #> TSC2            0.000000               0        0.000000              0 #>          X22_Y-91..CD4T X23_Y-86..CD4T X22_Y-99..CD4T X22_Y-103..CD4T #> PDK4                  0       0.000000       0.000000               0 #> TNFRSF17              0       0.000000       0.000000               0 #> ICAM3                 0       4.728857       5.262747               0 #> FAP                   0       0.000000       0.000000               0 #> GZMB                  0       0.000000       0.000000               0 #> TSC2                  0       0.000000       0.000000               0 #>          X23_Y-99..CD4T X25_Y-97..CD4T X28_Y-101..CD4T X27_Y-101..CD4T #> PDK4           0.000000       0.000000        0.000000        0.000000 #> TNFRSF17       0.000000       0.000000        0.000000        0.000000 #> ICAM3          2.595287       5.000537        3.230825        2.747486 #> FAP            0.000000       0.000000        0.000000        0.000000 #> GZMB           0.000000       1.624735        0.000000        0.000000 #> TSC2           0.000000       0.000000        0.000000        0.000000 #>          X29_Y-102..CD4T X27_Y-102..CD4T X28_Y-102..CD4T X26_Y-102..CD4T #> PDK4            0.000000         0.00000        0.000000        0.000000 #> TNFRSF17        0.000000         0.00000        0.000000        0.000000 #> ICAM3           1.569513         5.51308        3.175088        4.502979 #> FAP             0.000000         0.00000        0.000000        0.000000 #> GZMB            0.000000         0.00000        0.000000        0.000000 #> TSC2            0.000000         0.00000        0.000000        0.000000 #>          X28_Y-103..CD4T X25_Y-103..CD4T X24_Y-97..CD4T X29_Y-101..CD4T #> PDK4            0.000000        0.000000       0.000000        0.000000 #> TNFRSF17        0.000000        0.000000       0.000000        0.000000 #> ICAM3           4.588412        5.159809       5.125618        3.558484 #> FAP             0.000000        0.000000       0.000000        0.000000 #> GZMB            0.000000        0.000000       1.218551        0.000000 #> TSC2            0.000000        0.000000       0.000000        0.000000 #>          X74_Y-104..CD4T X77_Y-104..CD4T X74_Y-105..CD4T X73_Y-105..CD4T #> PDK4           0.0000000        0.000000       0.0000000        0.000000 #> TNFRSF17       0.0000000        0.000000       0.0000000        0.000000 #> ICAM3          0.9438981        2.376547       0.6742129        3.492406 #> FAP            0.0000000        0.000000       0.0000000        0.000000 #> GZMB           0.9483530        0.000000       1.4350100        0.000000 #> TSC2           0.0000000        0.000000       0.0000000        0.000000 #>          X75_Y-106..CD4T X73_Y-106..CD4T X74_Y-106..CD4T X75_Y-104..CD4T #> PDK4           0.0000000        0.000000        0.000000        0.000000 #> TNFRSF17       0.0000000        0.000000        0.000000        0.000000 #> ICAM3          0.9904241        3.617353        0.000000        4.996693 #> FAP            0.0000000        0.000000        0.000000        0.000000 #> GZMB           0.0000000        1.742247        1.742247        2.292929 #> TSC2           0.0000000        0.000000        0.000000        0.000000 #>          X73_Y-107..CD4T X62_Y-98..CD4T X63_Y-98..CD4T X60_Y-99..CD4T #> PDK4            0.000000       0.000000       0.000000       0.000000 #> TNFRSF17        0.000000       0.000000       0.000000       0.000000 #> ICAM3           0.000000       3.726855       4.887178       3.252285 #> FAP             0.000000       0.000000       0.000000       0.000000 #> GZMB            2.613371       0.000000       0.000000       0.000000 #> TSC2            0.000000       0.000000       0.000000       0.000000 #>          X65_Y-99..CD4T X62_Y-99..CD4T X61_Y-99..CD4T X63_Y-99..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.491555       1.218551       4.037312       5.880932 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X62_Y-100..CD4T X63_Y-100..CD4T X61_Y-100..CD4T X64_Y-100..CD4T #> PDK4            0.000000        0.000000        0.000000        0.000000 #> TNFRSF17        0.000000        0.000000        0.000000        0.000000 #> ICAM3           1.792362        2.580652        2.437103        2.557047 #> FAP             0.000000        0.000000        0.000000        0.000000 #> GZMB            0.000000        0.000000        0.000000        1.202947 #> TSC2            0.000000        0.000000        0.000000        0.000000 #>          X63_Y-101..CD4T X61_Y-101..CD4T X64_Y-101..CD4T X65_Y-101..CD4T #> PDK4                   0       0.0000000       0.0000000       0.0000000 #> TNFRSF17               0       0.0000000       0.0000000       0.0000000 #> ICAM3                  0       2.3459957       2.0478949       2.9481690 #> FAP                    0       0.0000000       0.0000000       0.0000000 #> GZMB                   0       0.5251932       0.6873982       0.9623575 #> TSC2                   0       0.0000000       0.0000000       0.0000000 #>          X62_Y-101..CD4T X66_Y-101..CD4T X64_Y-102..CD4T X62_Y-102..CD4T #> PDK4            0.000000        0.000000       0.0000000        0.000000 #> TNFRSF17        0.000000        0.000000       0.0000000        0.000000 #> ICAM3           3.756285        3.147809       0.6823076        3.138058 #> FAP             0.000000        0.000000       0.0000000        0.000000 #> GZMB            0.000000        0.000000       0.0000000        0.000000 #> TSC2            0.000000        0.000000       0.0000000        0.000000 #>          X66_Y-102..CD4T X61_Y-102..CD4T X60_Y-102..CD4T X64_Y-103..CD4T #> PDK4            0.000000        0.000000        0.000000        0.000000 #> TNFRSF17        0.000000        0.000000        0.000000        0.000000 #> ICAM3           1.065424        2.867496        2.470449        1.955021 #> FAP             0.000000        0.000000        0.000000        0.000000 #> GZMB            0.000000        0.000000        0.000000        0.537099 #> TSC2            0.000000        0.000000        0.000000        0.537099 #>          X63_Y-103..CD4T X65_Y-103..CD4T X62_Y-103..CD4T X61_Y-103..CD4T #> PDK4           0.0000000        0.000000        0.000000        0.000000 #> TNFRSF17       0.0000000        0.000000        0.000000        0.000000 #> ICAM3          3.4687772        2.332959        1.773293        3.760403 #> FAP            0.0000000        0.000000        0.000000        0.000000 #> GZMB           0.2417005        0.000000        0.000000        0.000000 #> TSC2           0.0000000        0.000000        0.000000        0.000000 #>          X63_Y-104..CD4T X61_Y-104..CD4T X63_Y-102..CD4T X64_Y-104..CD4T #> PDK4           0.0000000        0.000000       0.0000000       0.0000000 #> TNFRSF17       0.0000000        0.000000       0.0000000       0.0000000 #> ICAM3          1.8253908        1.308999       2.3709545       2.6759811 #> FAP            0.0000000        0.000000       0.0000000       0.0000000 #> GZMB           0.4296792        0.000000       0.6848181       0.3305225 #> TSC2           0.4296792        0.000000       0.0000000       0.3305225 #>          X23_Y-104..CD4T X23_Y-106..CD4T X24_Y-106..CD4T X22_Y-106..CD4T #> PDK4            0.000000        0.000000        0.000000        0.000000 #> TNFRSF17        0.000000        0.000000        0.000000        0.000000 #> ICAM3           4.062903        3.155227        3.953971        2.521216 #> FAP             0.000000        0.000000        0.000000        0.000000 #> GZMB            0.000000        0.000000        0.000000        0.000000 #> TSC2            0.000000        0.000000        0.000000        0.000000 #>          X21_Y-106..CD4T X22_Y-107..CD4T X69_Y-86..CD4T X70_Y-86..CD4T #> PDK4            0.000000        0.000000      0.0000000      0.0000000 #> TNFRSF17        0.000000        0.000000      0.0000000      0.0000000 #> ICAM3           3.323195        3.323195      3.9633981      3.4416295 #> FAP             0.000000        0.000000      0.0000000      0.0000000 #> GZMB            0.000000        0.000000      0.2217389      0.0000000 #> TSC2            0.000000        0.000000      0.2217389      0.2750825 #>          X68_Y-86..CD4T X67_Y-86..CD4T X71_Y-86..CD4T X68_Y-87..CD4T #> PDK4           0.000000      0.0000000        0.00000       0.000000 #> TNFRSF17       0.000000      0.0000000        0.00000       0.000000 #> ICAM3          2.329445      2.8112394        4.97356       3.782066 #> FAP            0.000000      0.0000000        0.00000       0.000000 #> GZMB           0.000000      0.0000000        0.00000       0.000000 #> TSC2           0.000000      0.2189387        0.00000       0.000000 #>          X69_Y-87..CD4T X70_Y-87..CD4T X68_Y-88..CD4T X69_Y-88..CD4T #> PDK4            0.00000              0       0.000000       0.000000 #> TNFRSF17        0.00000              0       0.000000       0.000000 #> ICAM3           3.07888              0       2.383524       2.402839 #> FAP             0.00000              0       0.000000       0.000000 #> GZMB            0.00000              0       0.000000       0.000000 #> TSC2            0.00000              0       0.000000       0.000000 #>          X72_Y-88..CD4T X71_Y-88..CD4T X71_Y-89..CD4T X68_Y-89..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          1.322255       1.322255       4.585859       2.329692 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X68_Y-90..CD4T X66_Y-86..CD4T X67_Y-87..CD4T X25_Y-104..CD4T #> PDK4           0.000000      0.0000000      0.0000000        0.000000 #> TNFRSF17       0.000000      0.0000000      0.0000000        0.000000 #> ICAM3          1.646949      2.3523015      4.0719090        5.159809 #> FAP            0.000000      0.0000000      0.0000000        0.000000 #> GZMB           0.000000      0.2519941      0.8189413        0.000000 #> TSC2           0.000000      0.0000000      0.0000000        0.000000 #>          X29_Y-104..CD4T X28_Y-105..CD4T X23_Y-105..CD4T X25_Y-105..CD4T #> PDK4                   0        0.000000        0.000000        0.000000 #> TNFRSF17               0        0.000000        0.000000        0.000000 #> ICAM3                  0        4.787888        4.182296        4.637509 #> FAP                    0        0.000000        0.000000        0.000000 #> GZMB                   0        0.000000        0.000000        1.387807 #> TSC2                   0        0.000000        0.000000        0.000000 #>          X24_Y-105..CD4T X25_Y-106..CD4T X26_Y-106..CD4T X26_Y-107..CD4T #> PDK4            0.000000        0.000000        0.000000       0.0000000 #> TNFRSF17        0.000000        0.000000        0.000000       0.0000000 #> ICAM3           4.520879        3.760926        4.012792       3.9444343 #> FAP             0.000000        0.000000        0.000000       0.0000000 #> GZMB            0.000000        1.498920        0.000000       0.9660202 #> TSC2            0.000000        0.000000        1.083301       0.8666407 #>          X25_Y-107..CD4T X27_Y-107..CD4T X24_Y-107..CD4T X27_Y-106..CD4T #> PDK4           0.0000000        0.000000        0.000000        0.000000 #> TNFRSF17       0.0000000        0.000000        0.000000        0.000000 #> ICAM3          3.7570790        5.634209        5.181734        5.747799 #> FAP            0.0000000        0.000000        0.000000        0.000000 #> GZMB           0.9660202        0.000000        0.000000        0.000000 #> TSC2           0.0000000        0.000000        0.000000        0.000000 #>          X69_Y-98..CD4T X72_Y-98..CD4T X67_Y-98..CD4T X69_Y-100..CD4T #> PDK4                  0       0.000000              0               0 #> TNFRSF17              0       0.000000              0               0 #> ICAM3                 0       2.376547              0               0 #> FAP                   0       0.000000              0               0 #> GZMB                  0       2.622667              0               0 #> TSC2                  0       0.000000              0               0 #>          X72_Y-102..CD4T X69_Y-102..CD4T X70_Y-102..CD4T X67_Y-103..CD4T #> PDK4            0.000000               0               0        0.000000 #> TNFRSF17        0.000000               0               0        0.000000 #> ICAM3           1.663444               0               0        0.000000 #> FAP             0.000000               0               0        0.000000 #> GZMB            0.000000               0               0        4.635125 #> TSC2            1.429890               0               0        0.000000 #>          X68_Y-103..CD4T X70_Y-99..CD4T X72_Y-100..CD4T X67_Y-102..CD4T #> PDK4            0.000000       0.000000               0        0.000000 #> TNFRSF17        0.000000       0.000000               0        0.000000 #> ICAM3           5.323408       2.569343               0        2.278723 #> FAP             0.000000       0.000000               0        0.000000 #> GZMB            0.000000       0.000000               0        0.000000 #> TSC2            0.000000       0.000000               0        0.000000 #>          X70_Y-104..CD4T X72_Y-104..CD4T X71_Y-104..CD4T X69_Y-104..CD4T #> PDK4            0.000000        0.000000       0.0000000        0.000000 #> TNFRSF17        0.000000        0.000000       0.0000000        0.000000 #> ICAM3           2.934486        2.788274       3.8040771        5.057837 #> FAP             0.000000        0.000000       0.0000000        0.000000 #> GZMB            0.000000        0.000000       0.0000000        0.000000 #> TSC2            0.000000        0.000000       0.9414259        0.000000 #>          X70_Y-105..CD4T X67_Y-105..CD4T X68_Y-105..CD4T X71_Y-105..CD4T #> PDK4            0.000000        0.000000        0.000000       0.0000000 #> TNFRSF17        0.000000        0.000000        0.000000       0.0000000 #> ICAM3           3.334977        2.980975        0.000000       4.0564592 #> FAP             0.000000        0.000000        0.000000       0.0000000 #> GZMB            0.000000        0.000000        2.221523       0.0000000 #> TSC2            0.000000        0.000000        0.000000       0.6276173 #>          X69_Y-105..CD4T X67_Y-106..CD4T X70_Y-106..CD4T X68_Y-106..CD4T #> PDK4            0.000000       0.0000000        0.000000        0.000000 #> TNFRSF17        0.000000       0.0000000        0.000000        0.000000 #> ICAM3           4.576296       0.7742138        1.363358        1.008486 #> FAP             0.000000       0.0000000        0.000000        0.000000 #> GZMB            0.000000       0.8959212        1.536109        0.000000 #> TSC2            0.000000       0.0000000        0.000000        0.000000 #>          X66_Y-106..CD4T X71_Y-106..CD4T X69_Y-107..CD4T X71_Y-107..CD4T #> PDK4            0.000000        0.000000        0.000000               0 #> TNFRSF17        0.000000        0.000000        0.000000               0 #> ICAM3           1.225081        2.054454        3.711592               0 #> FAP             0.000000        0.000000        0.000000               0 #> GZMB            1.153780        0.000000        0.000000               0 #> TSC2            0.000000        0.000000        0.000000               0 #>          X70_Y-107..CD4T X68_Y-107..CD4T X67_Y-104..CD4T X72_Y-105..CD4T #> PDK4            0.000000               0       0.0000000        0.000000 #> TNFRSF17        0.000000               0       0.0000000        0.000000 #> ICAM3           2.639745               0       1.8521631        5.630415 #> FAP             0.000000               0       0.0000000        0.000000 #> GZMB            1.536109               0       0.9210538        0.000000 #> TSC2            0.000000               0       0.0000000        0.000000 #>          X56_Y-103..CD4T X57_Y-104..CD4T X56_Y-104..CD4T X58_Y-104..CD4T #> PDK4            0.000000       0.0000000        0.000000       0.0000000 #> TNFRSF17        0.000000       0.0000000        0.000000       0.0000000 #> ICAM3           3.023332       0.9121775        1.049984       2.8893089 #> FAP             0.000000       0.0000000        0.000000       0.0000000 #> GZMB            0.000000       0.0000000        0.000000       0.5515678 #> TSC2            0.000000       0.0000000        0.000000       0.0000000 #>          X58_Y-105..CD4T X61_Y-105..CD4T X59_Y-105..CD4T X55_Y-105..CD4T #> PDK4            0.000000        0.000000        0.000000       0.0000000 #> TNFRSF17        0.000000        0.000000        0.000000       0.0000000 #> ICAM3           2.084964        1.492281        1.139361       1.9106391 #> FAP             0.000000        0.000000        0.000000       0.0000000 #> GZMB            0.000000        0.000000        0.000000       0.0000000 #> TSC2            0.000000        0.000000        0.000000       0.5379958 #>          X56_Y-105..CD4T X54_Y-105..CD4T X57_Y-106..CD4T X59_Y-106..CD4T #> PDK4            0.000000        0.000000          0.0000               0 #> TNFRSF17        0.000000        0.000000          0.0000               0 #> ICAM3           2.937144        4.543291          1.8411               0 #> FAP             0.000000        0.000000          0.0000               0 #> GZMB            0.000000        0.000000          0.0000               0 #> TSC2            0.000000        0.000000          0.0000               0 #>          X59_Y-103..CD4T X55_Y-104..CD4T X57_Y-105..CD4T X56_Y-106..CD4T #> PDK4            0.000000        0.000000         0.00000        0.000000 #> TNFRSF17        0.000000        0.000000         0.00000        0.000000 #> ICAM3           2.451002        5.278628         1.79181        2.686189 #> FAP             0.000000        0.000000         0.00000        0.000000 #> GZMB            0.000000        0.000000         0.00000        0.000000 #> TSC2            0.000000        0.000000         0.00000        0.000000 #>          X55_Y-107..CD4T X65_Y-104..CD4T X64_Y-105..CD4T X65_Y-105..CD4T #> PDK4            0.000000       0.0000000        0.000000       0.0000000 #> TNFRSF17        0.000000       0.0000000        0.000000       0.0000000 #> ICAM3           2.103244       4.1044725        2.276021       2.8716802 #> FAP             0.000000       0.0000000        0.000000       0.0000000 #> GZMB            0.949815       0.0000000        0.000000       0.0000000 #> TSC2            0.000000       0.3648978        0.000000       0.4378773 #>          X66_Y-105..CD4T X63_Y-105..CD4T X64_Y-106..CD4T X63_Y-106..CD4T #> PDK4           0.0000000        0.000000         0.00000        0.000000 #> TNFRSF17       0.0000000        0.000000         0.00000        0.000000 #> ICAM3          2.0781384        2.227338         2.18553        2.089267 #> FAP            0.0000000        0.000000         0.00000        0.000000 #> GZMB           0.6593029        0.000000         0.00000        0.000000 #> TSC2           0.0000000        0.000000         0.00000        0.000000 #>          X65_Y-106..CD4T X64_Y-107..CD4T X65_Y-107..CD4T X49_Y-103..CD4T #> PDK4                   0         0.00000       0.0000000       0.0000000 #> TNFRSF17               0         0.00000       0.0000000       0.0000000 #> ICAM3                  0         1.30471       0.6856808       1.9409339 #> FAP                    0         0.00000       0.0000000       0.0000000 #> GZMB                   0         0.00000       0.0000000       0.7740249 #> TSC2                   0         0.00000       0.0000000       0.0000000 #>          X50_Y-104..CD4T X49_Y-104..CD4T X53_Y-104..CD4T X52_Y-104..CD4T #> PDK4            0.000000        0.000000         0.00000         0.00000 #> TNFRSF17        0.000000        0.000000         0.00000         0.00000 #> ICAM3           5.130296        2.505804         3.66332         2.91337 #> FAP             0.000000        0.000000         0.00000         0.00000 #> GZMB            0.000000        0.000000         0.00000         0.00000 #> TSC2            0.000000        0.000000         0.00000         0.00000 #>          X52_Y-105..CD4T X49_Y-106..CD4T X53_Y-106..CD4T X50_Y-106..CD4T #> PDK4            0.000000        0.000000        0.000000               0 #> TNFRSF17        0.000000        0.000000        0.000000               0 #> ICAM3           2.670201        4.601027        2.297758               0 #> FAP             0.000000        0.000000        0.000000               0 #> GZMB            0.000000        0.000000        0.000000               0 #> TSC2            0.000000        0.000000        0.000000               0 #>          X48_Y-106..CD4T X54_Y-107..CD4T X53_Y-107..CD4T X48_Y-107..CD4T #> PDK4            0.000000        0.000000        0.000000               0 #> TNFRSF17        0.000000        0.000000        0.000000               0 #> ICAM3           1.592051        2.359745        2.247271               0 #> FAP             0.000000        0.000000        0.000000               0 #> GZMB            0.000000        0.000000        0.000000               0 #> TSC2            0.000000        0.000000        0.000000               0 #>          X52_Y-107..CD4T X51_Y-107..CD4T X53_Y-105..CD4T X49_Y-105..CD4T #> PDK4            0.000000               0        0.000000        0.000000 #> TNFRSF17        0.000000               0        0.000000        0.000000 #> ICAM3           4.062903               0        2.803089        4.529834 #> FAP             0.000000               0        0.000000        0.000000 #> GZMB            0.000000               0        0.000000        0.000000 #> TSC2            0.000000               0        0.000000        0.000000 #>          X51_Y-106..CD4T X50_Y-107..CD4T X33_Y-104..CD4T X34_Y-104..CD4T #> PDK4            0.000000          0.0000        0.000000        0.000000 #> TNFRSF17        0.000000          0.0000        0.000000        0.000000 #> ICAM3           5.537982          4.5208        5.421048        3.613134 #> FAP             0.000000          0.0000        0.000000        0.000000 #> GZMB            0.000000          0.0000        0.000000        0.000000 #> TSC2            0.000000          0.0000        0.000000        0.000000 #>          X35_Y-104..CD4T X31_Y-104..CD4T X33_Y-105..CD4T X30_Y-107..CD4T #> PDK4             0.00000         0.00000        0.000000               0 #> TNFRSF17         0.00000         0.00000        0.000000               0 #> ICAM3            5.08532         5.44192        4.625072               0 #> FAP              0.00000         0.00000        0.000000               0 #> GZMB             0.00000         0.00000        0.000000               0 #> TSC2             0.00000         0.00000        0.000000               0 #>          X48_Y-105..CD4T X43_Y-105..CD4T X46_Y-106..CD4T X47_Y-106..CD4T #> PDK4           0.0000000        0.000000        0.000000        0.000000 #> TNFRSF17       0.0000000        0.000000        0.000000        0.000000 #> ICAM3          3.8152068        4.472554        3.306266        1.139361 #> FAP            0.0000000        0.000000        0.000000        0.000000 #> GZMB           0.0000000        0.000000        0.000000        0.000000 #> TSC2           0.9188316        0.000000        0.000000        0.000000 #>          X45_Y-107..CD4T X47_Y-107..CD4T X45_Y-106..CD4T X46_Y-107..CD4T #> PDK4            0.000000        0.000000        0.000000          0.0000 #> TNFRSF17        0.000000        0.000000        0.000000          0.0000 #> ICAM3           2.880533        3.123078        2.430701          4.3208 #> FAP             0.000000        0.000000        0.000000          0.0000 #> GZMB            0.000000        0.000000        0.000000          0.0000 #> TSC2            0.000000        0.000000        0.000000          0.0000 #>          X58_Y-98..CD4T X57_Y-98..CD4T X60_Y-98..CD4T X59_Y-98..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          3.446558       1.719406       3.800008       3.659112 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X55_Y-98..CD4T X58_Y-99..CD4T X55_Y-99..CD4T X57_Y-99..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.393989       2.770611       1.569541       1.196972 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.537189       0.000000       0.000000       0.000000 #>          X54_Y-99..CD4T X59_Y-99..CD4T X55_Y-100..CD4T X59_Y-100..CD4T #> PDK4           0.000000       0.000000        0.000000        0.000000 #> TNFRSF17       0.000000       0.000000        0.000000        0.000000 #> ICAM3          1.424685       2.630875        3.497614        4.031577 #> FAP            0.000000       0.000000        0.000000        0.000000 #> GZMB           0.000000       0.000000        0.000000        0.000000 #> TSC2           0.000000       0.000000        0.000000        0.000000 #>          X57_Y-100..CD4T X58_Y-100..CD4T X60_Y-100..CD4T X59_Y-101..CD4T #> PDK4            0.000000        0.000000        0.000000        0.000000 #> TNFRSF17        0.000000        0.000000        0.000000        0.000000 #> ICAM3           4.776417        4.846483        5.026725        4.222276 #> FAP             0.000000        0.000000        0.000000        0.000000 #> GZMB            0.000000        0.000000        0.000000        0.000000 #> TSC2            0.000000        0.000000        0.000000        0.000000 #>          X58_Y-101..CD4T X56_Y-101..CD4T X55_Y-101..CD4T X60_Y-101..CD4T #> PDK4            0.000000               0        0.000000        0.000000 #> TNFRSF17        0.000000               0        0.000000        0.000000 #> ICAM3           4.453213               0        2.343499        1.400515 #> FAP             0.000000               0        0.000000        0.000000 #> GZMB            0.000000               0        0.000000        2.727895 #> TSC2            0.000000               0        0.000000        0.000000 #>          X57_Y-101..CD4T X57_Y-102..CD4T X59_Y-102..CD4T X58_Y-102..CD4T #> PDK4            0.000000        0.000000        0.000000        0.000000 #> TNFRSF17        0.000000        0.000000        0.000000        0.000000 #> ICAM3           5.149528        3.089717        2.828111        4.924887 #> FAP             0.000000        0.000000        0.000000        0.000000 #> GZMB            0.000000        0.000000        0.000000        0.000000 #> TSC2            0.000000        0.000000        0.000000        0.000000 #>          X57_Y-103..CD4T X60_Y-103..CD4T X58_Y-103..CD4T X56_Y-99..CD4T #> PDK4                   0        0.000000        0.000000      0.0000000 #> TNFRSF17               0        0.000000        0.000000      0.0000000 #> ICAM3                  0        1.736164        1.876805      3.1192857 #> FAP                    0        0.000000        0.000000      0.0000000 #> GZMB                   0        0.000000        1.286991      0.0000000 #> TSC2                   0        0.000000        0.000000      0.5158426 #>          X54_Y-100..CD4T X56_Y-100..CD4T X42_Y-98..CD4T X40_Y-99..CD4T #> PDK4            0.000000        0.000000              0              0 #> TNFRSF17        0.000000        0.000000              0              0 #> ICAM3           2.923452        5.050104              0              0 #> FAP             0.000000        0.000000              0              0 #> GZMB            0.000000        0.000000              0              0 #> TSC2            0.000000        0.000000              0              0 #>          X42_Y-99..CD4T X38_Y-100..CD4T X39_Y-100..CD4T X42_Y-100..CD4T #> PDK4           0.000000        0.000000         0.00000        0.000000 #> TNFRSF17       0.000000        0.000000         0.00000        0.000000 #> ICAM3          2.243233        5.631974         5.13598        2.493623 #> FAP            0.000000        0.000000         0.00000        0.000000 #> GZMB           0.000000        0.000000         0.00000        0.000000 #> TSC2           0.000000        0.000000         0.00000        0.000000 #>          X41_Y-101..CD4T X42_Y-101..CD4T X41_Y-102..CD4T X41_Y-103..CD4T #> PDK4            0.000000        0.000000        0.000000        0.000000 #> TNFRSF17        0.000000        0.000000        0.000000        0.000000 #> ICAM3           1.810625        1.039213        2.313935        1.531839 #> FAP             0.000000        0.000000        0.000000        0.000000 #> GZMB            0.000000        0.000000        0.000000        0.000000 #> TSC2            0.000000        0.000000        0.000000        0.000000 #>          X42_Y-103..CD4T X63_Y-86..CD4T X64_Y-86..CD4T X62_Y-86..CD4T #> PDK4            0.000000      0.0000000      0.0000000       0.000000 #> TNFRSF17        0.000000      0.0000000      0.0000000       0.000000 #> ICAM3           1.714088      2.7502745      2.7260971       2.943564 #> FAP             0.000000      0.0000000      0.0000000       0.000000 #> GZMB            0.000000      0.3184102      0.3184102       0.000000 #> TSC2            1.064682      0.2878984      0.0000000       1.199941 #>          X61_Y-86..CD4T X65_Y-86..CD4T X63_Y-87..CD4T X65_Y-87..CD4T #> PDK4           0.000000       0.000000       0.000000              0 #> TNFRSF17       0.000000       0.000000       0.000000              0 #> ICAM3          2.568591       3.154723       2.771202              0 #> FAP            0.000000       0.000000       0.000000              0 #> GZMB           0.000000       0.000000       0.000000              0 #> TSC2           0.453010       0.000000       0.000000              0 #>          X61_Y-87..CD4T X62_Y-87..CD4T X66_Y-87..CD4T X64_Y-87..CD4T #> PDK4           0.000000      0.0000000      0.0000000       0.000000 #> TNFRSF17       0.000000      0.0000000      0.0000000       0.000000 #> ICAM3          3.003513      3.0193249      2.9767598       3.835508 #> FAP            0.000000      0.0000000      0.0000000       0.000000 #> GZMB           0.000000      0.0000000      0.9827296       1.087039 #> TSC2           0.000000      0.4799766      0.0000000       0.000000 #>          X62_Y-88..CD4T X63_Y-88..CD4T X66_Y-88..CD4T X63_Y-89..CD4T #> PDK4           0.000000       0.000000       0.000000      0.0000000 #> TNFRSF17       0.000000       0.000000       0.000000      0.0000000 #> ICAM3          3.426962       4.008434       2.682441      2.5243719 #> FAP            0.000000       0.000000       0.000000      0.0000000 #> GZMB           0.000000       0.000000       0.000000      0.0000000 #> TSC2           0.000000       0.000000       0.000000      0.2365282 #>          X64_Y-89..CD4T X62_Y-89..CD4T X64_Y-90..CD4T X62_Y-90..CD4T #> PDK4           0.000000       0.000000      0.0000000      0.0000000 #> TNFRSF17       0.000000       0.000000      0.0000000      0.0000000 #> ICAM3          2.155859       1.539281      2.1741160      3.4608055 #> FAP            0.000000       0.000000      0.0000000      0.0000000 #> GZMB           0.000000       0.000000      0.9526613      0.2491932 #> TSC2           0.000000       0.000000      0.0000000      0.2459210 #>          X61_Y-90..CD4T X63_Y-90..CD4T X66_Y-90..CD4T X64_Y-88..CD4T #> PDK4           0.000000      0.0000000       0.000000       0.000000 #> TNFRSF17       0.000000      0.0000000       0.000000       0.000000 #> ICAM3          1.995478      3.7661280       4.650401       2.297758 #> FAP            0.000000      0.0000000       0.000000       0.000000 #> GZMB           0.000000      0.2130847       0.000000       0.000000 #> TSC2           0.000000      0.2213289       3.966766       0.000000 #>          X41_Y-92..CD4T X39_Y-92..CD4T X41_Y-93..CD4T X36_Y-93..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          1.765212       4.085632       1.067153       3.202189 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X38_Y-94..CD4T X39_Y-94..CD4T X37_Y-95..CD4T X41_Y-95..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          3.390351       5.089387       4.234501       2.704084 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X41_Y-96..CD4T X42_Y-96..CD4T X41_Y-97..CD4T X40_Y-97..CD4T #> PDK4           0.000000       0.000000       0.000000              0 #> TNFRSF17       0.000000       0.000000       0.000000              0 #> ICAM3          4.086292       3.262131       4.679647              0 #> FAP            0.000000       0.000000       0.000000              0 #> GZMB           0.000000       0.000000       0.000000              0 #> TSC2           0.000000       0.000000       0.000000              0 #>          X41_Y-104..CD4T X40_Y-104..CD4T X40_Y-105..CD4T X41_Y-105..CD4T #> PDK4            0.000000        0.000000       0.0000000        0.000000 #> TNFRSF17        0.000000        0.000000       0.0000000        0.000000 #> ICAM3           4.846617        3.620681       2.3025049        3.267796 #> FAP             0.000000        0.000000       0.0000000        0.000000 #> GZMB            1.021408        1.021408       0.6809387        1.021408 #> TSC2            0.000000        0.000000       0.0000000        0.000000 #>          X42_Y-105..CD4T X40_Y-106..CD4T X41_Y-106..CD4T X42_Y-106..CD4T #> PDK4            0.000000        0.000000        0.000000               0 #> TNFRSF17        0.000000        0.000000        0.000000               0 #> ICAM3           3.922071        1.143436        1.844187               0 #> FAP             0.000000        0.000000        0.000000               0 #> GZMB            0.000000        0.000000        0.000000               0 #> TSC2            0.000000        0.000000        0.000000               0 #>          X40_Y-107..CD4T X41_Y-107..CD4T X53_Y-85..CD4T X52_Y-86..CD4T #> PDK4           0.0000000       0.0000000       0.000000       0.000000 #> TNFRSF17       0.0000000       0.0000000       0.000000       0.000000 #> ICAM3          1.8954818       1.9553863       2.386111       2.420395 #> FAP            0.0000000       0.0000000       0.000000       0.000000 #> GZMB           0.3926936       0.4363262       0.000000       0.000000 #> TSC2           0.0000000       0.0000000       0.000000       0.000000 #>          X51_Y-86..CD4T X53_Y-86..CD4T X54_Y-86..CD4T X54_Y-87..CD4T #> PDK4           0.000000       0.000000      0.0000000      0.0000000 #> TNFRSF17       0.000000       0.000000      0.0000000      0.0000000 #> ICAM3          1.008866       3.330255      2.0417234      2.4330027 #> FAP            0.000000       0.000000      0.0000000      0.0000000 #> GZMB           0.000000       0.000000      0.6607245      0.3303623 #> TSC2           0.000000       0.000000      0.0000000      0.0000000 #>          X52_Y-87..CD4T X51_Y-87..CD4T X53_Y-87..CD4T X50_Y-87..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.279614       2.335344       3.180146       3.142733 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X49_Y-88..CD4T X52_Y-88..CD4T X51_Y-88..CD4T X54_Y-88..CD4T #> PDK4           0.000000       0.000000      0.0000000       0.000000 #> TNFRSF17       0.000000       0.000000      0.0000000       0.000000 #> ICAM3          2.037083       2.238497      2.0879430       2.427409 #> FAP            0.000000       0.000000      0.0000000       0.000000 #> GZMB           0.000000       0.000000      0.0000000       0.000000 #> TSC2           0.000000       0.000000      0.2653912       0.000000 #>          X53_Y-88..CD4T X50_Y-88..CD4T X48_Y-88..CD4T X53_Y-89..CD4T #> PDK4          0.0000000      0.0000000       0.000000      0.0000000 #> TNFRSF17      0.0000000      0.0000000       0.000000      0.0000000 #> ICAM3         2.1992076      2.4403847       2.498805      2.2747936 #> FAP           0.0000000      0.0000000       0.000000      0.0000000 #> GZMB          0.2903064      0.3386448       0.000000      0.4103065 #> TSC2          0.0000000      0.3878794       0.000000      0.4103065 #>          X52_Y-89..CD4T X54_Y-89..CD4T X50_Y-89..CD4T X49_Y-89..CD4T #> PDK4           0.000000       0.000000      0.0000000       0.000000 #> TNFRSF17       0.000000       0.000000      0.0000000       0.000000 #> ICAM3          3.266128       2.010267      2.6573552       3.631671 #> FAP            0.000000       0.000000      0.0000000       0.000000 #> GZMB           0.000000       0.000000      0.6289118       0.000000 #> TSC2           0.000000       0.000000      0.0000000       0.000000 #>          X51_Y-89..CD4T X50_Y-90..CD4T X54_Y-90..CD4T X49_Y-90..CD4T #> PDK4           0.000000      0.0000000      0.0000000       0.000000 #> TNFRSF17       0.000000      0.0000000      0.0000000       0.000000 #> ICAM3          4.683135      1.7611875      1.7400629       2.147897 #> FAP            0.000000      0.0000000      0.0000000       0.000000 #> GZMB           0.000000      0.0000000      0.5033148       0.000000 #> TSC2           0.000000      0.6125405      0.0000000       0.000000 #>          X53_Y-90..CD4T X51_Y-90..CD4T X52_Y-90..CD4T X52_Y-91..CD4T #> PDK4           0.000000       0.000000      0.0000000       0.000000 #> TNFRSF17       0.000000       0.000000      0.0000000       0.000000 #> ICAM3          4.625072       3.289106      2.4508600       1.569955 #> FAP            0.000000       0.000000      0.0000000       0.000000 #> GZMB           0.000000       0.000000      0.4689218       0.000000 #> TSC2           0.000000       0.000000      0.4689218       0.000000 #>          X53_Y-91..CD4T X55_Y-85..CD4T X57_Y-85..CD4T X60_Y-86..CD4T #> PDK4                  0       0.000000              0      0.0000000 #> TNFRSF17              0       0.000000              0      0.0000000 #> ICAM3                 0       4.013637              0      2.6636185 #> FAP                   0       0.000000              0      0.0000000 #> GZMB                  0       0.000000              0      0.5095399 #> TSC2                  0       0.000000              0      0.0000000 #>          X59_Y-86..CD4T X58_Y-86..CD4T X56_Y-86..CD4T X59_Y-87..CD4T #> PDK4           0.000000      0.0000000       0.000000       0.000000 #> TNFRSF17       0.000000      0.0000000       0.000000       0.000000 #> ICAM3          1.442402      0.7181806       2.583753       2.824237 #> FAP            0.000000      0.0000000       0.000000       0.000000 #> GZMB           0.000000      0.0000000       0.000000       0.804874 #> TSC2           0.000000      0.0000000       0.000000       0.000000 #>          X56_Y-87..CD4T X57_Y-87..CD4T X55_Y-88..CD4T X57_Y-88..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          1.556809       2.699422       1.373178       1.994705 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X58_Y-88..CD4T X57_Y-89..CD4T X55_Y-89..CD4T X56_Y-89..CD4T #> PDK4             0.0000      0.0000000        0.00000       0.000000 #> TNFRSF17         0.0000      0.0000000        0.00000       0.000000 #> ICAM3            1.7147      2.6527565        1.86821       1.622743 #> FAP              0.0000      0.0000000        0.00000       0.000000 #> GZMB             0.0000      0.3114399        0.00000       0.000000 #> TSC2             0.0000      0.0000000        0.00000       0.000000 #>          X58_Y-89..CD4T X57_Y-90..CD4T X55_Y-90..CD4T X56_Y-90..CD4T #> PDK4          0.0000000      0.0000000      0.0000000      0.0000000 #> TNFRSF17      0.0000000      0.0000000      0.0000000      0.0000000 #> ICAM3         2.7925208      3.7455124      2.7368811      2.2205403 #> FAP           0.0000000      0.0000000      0.0000000      0.0000000 #> GZMB          0.4671599      0.0000000      0.5033148      0.3629768 #> TSC2          0.0000000      0.2471757      0.0000000      0.0000000 #>          X58_Y-90..CD4T X55_Y-86..CD4T X58_Y-87..CD4T X59_Y-89..CD4T #> PDK4           0.000000       0.000000       0.000000              0 #> TNFRSF17       0.000000       0.000000       0.000000              0 #> ICAM3          2.334596       4.485477       2.012185              0 #> FAP            0.000000       0.000000       0.000000              0 #> GZMB           0.000000       0.000000       2.012185              0 #> TSC2           0.000000       0.000000       0.000000              0 #>          X59_Y-90..CD4T X55_Y-64..CD4T X56_Y-65..CD4T X55_Y-66..CD4T #> PDK4           0.000000       0.000000       0.000000      0.0000000 #> TNFRSF17       0.000000       0.000000       0.000000      0.0000000 #> ICAM3          2.386402       3.345307       2.010557      2.8650200 #> FAP            0.000000       0.000000       0.000000      0.0000000 #> GZMB           0.000000       0.000000       0.000000      0.0000000 #> TSC2           0.000000       0.000000       0.000000      0.6193419 #>          X56_Y-64..CD4T X72_Y-64..CD4T X72_Y-65..CD4T X71_Y-65..CD4T #> PDK4            0.00000       0.000000       0.000000       0.000000 #> TNFRSF17        0.00000       0.000000       0.000000       0.000000 #> ICAM3           2.28222       3.380598       2.387769       2.947649 #> FAP             0.00000       0.000000       0.000000       0.000000 #> GZMB            0.00000       0.000000       0.000000       0.000000 #> TSC2            0.00000       0.000000       0.000000       0.000000 #>          X70_Y-64..CD4T X71_Y-66..CD4T X67_Y-66..CD4T X70_Y-66..CD4T #> PDK4                  0       0.000000       0.000000       0.000000 #> TNFRSF17              0       0.000000       0.000000       0.000000 #> ICAM3                 0       2.009494       4.730565       4.418446 #> FAP                   0       0.000000       0.000000       0.000000 #> GZMB                  0       0.000000       5.419291       0.000000 #> TSC2                  0       0.000000       0.000000       0.000000 #>          X49_Y-99..CD4T X52_Y-99..CD4T X53_Y-100..CD4T X52_Y-100..CD4T #> PDK4            0.00000       0.000000        0.000000         0.00000 #> TNFRSF17        0.00000       0.000000        0.000000         0.00000 #> ICAM3           2.72096       2.324919        2.256656         1.46089 #> FAP             0.00000       0.000000        0.000000         0.00000 #> GZMB            0.00000       0.000000        0.000000         0.00000 #> TSC2            0.00000       0.000000        0.000000         0.00000 #>          X50_Y-100..CD4T X49_Y-100..CD4T X48_Y-100..CD4T X49_Y-101..CD4T #> PDK4             0.00000        0.000000        0.000000        0.000000 #> TNFRSF17         0.00000        0.000000        0.000000        0.000000 #> ICAM3            2.09983        2.718009        4.941713        1.570502 #> FAP              0.00000        0.000000        0.000000        0.000000 #> GZMB             0.00000        0.000000        0.000000        0.000000 #> TSC2             0.00000        0.000000        0.000000        0.000000 #>          X48_Y-101..CD4T X51_Y-101..CD4T X53_Y-101..CD4T X53_Y-102..CD4T #> PDK4            0.000000               0               0               0 #> TNFRSF17        0.000000               0               0               0 #> ICAM3           2.758504               0               0               0 #> FAP             0.000000               0               0               0 #> GZMB            0.000000               0               0               0 #> TSC2            0.000000               0               0               0 #>          X50_Y-102..CD4T X49_Y-102..CD4T X52_Y-102..CD4T X55_Y-103..CD4T #> PDK4            0.000000        0.000000        0.000000        0.000000 #> TNFRSF17        0.000000        0.000000        0.000000        0.000000 #> ICAM3           2.306958        1.325826        1.893269        4.392397 #> FAP             0.000000        0.000000        0.000000        0.000000 #> GZMB            0.000000        0.000000        0.000000        0.000000 #> TSC2            0.000000        0.000000        1.893269        0.000000 #>          X51_Y-104..CD4T X54_Y-104..CD4T X49_Y-98..CD4T X50_Y-99..CD4T #> PDK4               0.000        0.000000        0.00000       0.000000 #> TNFRSF17           0.000        0.000000        0.00000       0.000000 #> ICAM3              4.714        3.443066        2.72096       2.389325 #> FAP                0.000        0.000000        0.00000       0.000000 #> GZMB               0.000        0.000000        0.00000       0.000000 #> TSC2               0.000        0.000000        0.00000       0.000000 #>          X51_Y-99..CD4T X51_Y-100..CD4T X52_Y-101..CD4T X54_Y-101..CD4T #> PDK4           0.000000         0.00000               0               0 #> TNFRSF17       0.000000         0.00000               0               0 #> ICAM3          1.612094         1.20907               0               0 #> FAP            0.000000         0.00000               0               0 #> GZMB           0.000000         0.00000               0               0 #> TSC2           0.000000         0.00000               0               0 #>          X44_Y-98..CD4T X47_Y-98..CD4T X48_Y-99..CD4T X43_Y-99..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          3.635371       1.506933       3.168274       3.273992 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       1.377586       0.000000 #>          X43_Y-100..CD4T X44_Y-100..CD4T X44_Y-101..CD4T X47_Y-101..CD4T #> PDK4            0.000000        0.000000        0.000000       0.0000000 #> TNFRSF17        0.000000        0.000000        0.000000       0.0000000 #> ICAM3           2.192507        3.297118        4.200292       0.9994398 #> FAP             0.000000        0.000000        0.000000       0.0000000 #> GZMB            0.000000        0.000000        0.000000       0.0000000 #> TSC2            0.000000        0.000000        0.000000       0.0000000 #>          X46_Y-101..CD4T X42_Y-102..CD4T X43_Y-102..CD4T X47_Y-100..CD4T #> PDK4            0.000000        0.000000        0.000000        0.000000 #> TNFRSF17        0.000000        0.000000        0.000000        0.000000 #> ICAM3           3.997759        2.331420        3.559705        2.888209 #> FAP             0.000000        0.000000        0.000000        0.000000 #> GZMB            0.000000        0.000000        0.000000        0.000000 #> TSC2            0.000000        0.665426        0.000000        0.000000 #>          X48_Y-102..CD4T X44_Y-102..CD4T X43_Y-103..CD4T X47_Y-103..CD4T #> PDK4            0.000000               0               0        0.000000 #> TNFRSF17        0.000000               0               0        0.000000 #> ICAM3           2.651652               0               0        2.658331 #> FAP             0.000000               0               0        0.000000 #> GZMB            0.000000               0               0        0.000000 #> TSC2            0.000000               0               0        0.000000 #>          X28_Y-94..CD8T X26_Y-96..CD8T X26_Y-97..CD8T X27_Y-96..CD8T #> PDK4                  0       0.000000       0.000000              0 #> TNFRSF17              0       0.000000       0.000000              0 #> ICAM3                 0       2.636273       2.877562              0 #> FAP                   0       0.000000       0.000000              0 #> GZMB                  0       0.000000       0.000000              0 #> TSC2                  0       0.000000       0.000000              0 #>          X64_Y-91..CD8T X61_Y-91..CD8T X62_Y-91..CD8T X61_Y-92..CD8T #> PDK4           0.000000       0.000000       0.000000      0.0000000 #> TNFRSF17       0.000000       0.000000       0.000000      0.0000000 #> ICAM3          0.000000       4.066063       5.639749      2.6656890 #> FAP            0.000000       0.000000       0.000000      0.0000000 #> GZMB           4.214594       1.246369       4.749024      0.5807491 #> TSC2           0.000000       0.000000       0.000000      0.0000000 #>          X60_Y-92..CD8T X64_Y-92..CD8T X62_Y-93..CD8T X64_Y-93..CD8T #> PDK4           0.000000        0.00000       0.000000       0.000000 #> TNFRSF17       0.000000        0.00000       0.000000       0.000000 #> ICAM3          3.086627        5.50999       2.671751       3.673326 #> FAP            0.000000        0.00000       0.000000       0.000000 #> GZMB           0.000000        0.00000       0.000000       0.000000 #> TSC2           0.000000        0.00000       0.000000       1.707326 #>          X64_Y-94..CD8T X63_Y-95..CD8T X62_Y-96..CD8T X62_Y-92..CD8T #> PDK4           0.000000        0.00000              0      0.0000000 #> TNFRSF17       0.000000        0.00000              0      0.0000000 #> ICAM3          2.052819        0.00000              0      2.6481131 #> FAP            0.000000        0.00000              0      0.0000000 #> GZMB           0.000000        5.32853              0      0.7759244 #> TSC2           1.707326        0.00000              0      0.0000000 #>          X58_Y-91..CD8T X57_Y-91..CD8T X59_Y-91..CD8T X55_Y-92..CD8T #> PDK4          0.0000000      0.0000000      0.0000000       0.000000 #> TNFRSF17      0.0000000      0.0000000      0.0000000       0.000000 #> ICAM3         3.5450852      3.2825575      1.5833438       0.000000 #> FAP           0.0000000      0.0000000      0.0000000       0.000000 #> GZMB          0.5533222      0.7222006      2.3105681       2.393944 #> TSC2          0.5268242      0.0000000      0.7902942       0.000000 #>          X56_Y-92..CD8T X58_Y-92..CD8T X59_Y-92..CD8T X58_Y-93..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          0.000000       3.231059       3.851422       5.416065 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           4.989231       0.000000       1.900406       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X59_Y-93..CD8T X54_Y-93..CD8T X57_Y-93..CD8T X55_Y-94..CD8T #> PDK4           0.000000      0.0000000       0.000000       0.000000 #> TNFRSF17       0.000000      0.0000000       0.000000       0.000000 #> ICAM3          4.529207      3.0791222       4.836282       1.711365 #> FAP            0.000000      0.0000000       0.000000       0.000000 #> GZMB           1.284671      0.0000000       0.000000       1.598592 #> TSC2           0.000000      0.7389961       0.000000       0.000000 #>          X59_Y-94..CD8T X54_Y-94..CD8T X60_Y-94..CD8T X55_Y-95..CD8T #> PDK4           0.000000      0.0000000       0.000000       0.000000 #> TNFRSF17       0.000000      0.0000000       0.000000       0.000000 #> ICAM3          1.828266      2.2379415       0.000000       2.256974 #> FAP            0.000000      0.0000000       0.000000       0.000000 #> GZMB           0.000000      0.6725372       0.000000       1.408283 #> TSC2           1.595963      0.0000000       2.393944       0.000000 #>          X57_Y-95..CD8T X56_Y-95..CD8T X57_Y-96..CD8T X56_Y-96..CD8T #> PDK4           0.000000      0.0000000      0.0000000      0.0000000 #> TNFRSF17       0.000000      0.0000000      0.0000000      0.0000000 #> ICAM3          2.947211      2.4540000      2.5937309      3.3763498 #> FAP            0.000000      0.0000000      0.0000000      0.0000000 #> GZMB           0.000000      0.4665919      0.5196002      0.3597232 #> TSC2           0.000000      0.0000000      0.0000000      0.3759368 #>          X59_Y-96..CD8T X58_Y-96..CD8T X58_Y-97..CD8T X55_Y-97..CD8T #> PDK4                  0       0.000000       0.000000      0.0000000 #> TNFRSF17              0       0.000000       0.000000      0.0000000 #> ICAM3                 0       2.456824       2.308031      2.4964971 #> FAP                   0       0.000000       0.000000      0.0000000 #> GZMB                  0       0.000000       2.458916      0.9943451 #> TSC2                  0       2.213289       0.000000      0.0000000 #>          X56_Y-97..CD8T X59_Y-97..CD8T X57_Y-97..CD8T X56_Y-94..CD8T #> PDK4          0.0000000       0.000000      0.0000000       0.000000 #> TNFRSF17      0.0000000       0.000000      0.0000000       0.000000 #> ICAM3         3.4304663       3.105362      0.7691868       1.725327 #> FAP           0.0000000       0.000000      0.0000000       0.000000 #> GZMB          0.0000000       3.253465      0.9195312       1.430525 #> TSC2          0.3054486       0.000000      0.0000000       0.000000 #>          X55_Y-98..CD8T X75_Y-98..CD8T X77_Y-99..CD8T X77_Y-85..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.537762       0.000000       5.303305       5.264283 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           1.612432       0.000000       0.000000       0.000000 #> TSC2           0.303916       4.741765       0.000000       0.000000 #>          X75_Y-90..CD8T X78_Y-91..CD8T X30_Y-73..CD8T X39_Y-70..CD8T #> PDK4           0.000000        0.00000       0.000000       0.000000 #> TNFRSF17       0.000000        0.00000       0.000000       0.000000 #> ICAM3          5.550671        5.46899       0.000000       4.817854 #> FAP            0.000000        0.00000       0.000000       0.000000 #> GZMB           0.000000        5.46899       5.476862       0.000000 #> TSC2           0.000000        0.00000       0.000000       0.000000 #>          X40_Y-72..CD8T X39_Y-72..CD8T X41_Y-68..CD8T X40_Y-73..CD8T #> PDK4          0.0000000      0.0000000       0.000000       0.000000 #> TNFRSF17      0.0000000      0.0000000       0.000000       0.000000 #> ICAM3         0.9942467      0.9942467       5.658486       1.988493 #> FAP           0.0000000      0.0000000       0.000000       0.000000 #> GZMB          0.0000000      0.0000000       0.000000       0.000000 #> TSC2          0.0000000      0.0000000       0.000000       0.000000 #>          X40_Y-75..CD8T X37_Y-78..CD8T X39_Y-75..CD8T X73_Y-73..CD8T #> PDK4             0.0000       0.000000         0.0000      0.0000000 #> TNFRSF17         0.0000       0.000000         0.0000      0.0000000 #> ICAM3            2.0457       5.364882         2.0457      3.2555468 #> FAP              0.0000       0.000000         0.0000      0.0000000 #> GZMB             0.0000       0.000000         0.0000      0.0000000 #> TSC2             0.0000       0.000000         0.0000      0.8145297 #>          X74_Y-73..CD8T X77_Y-74..CD8T X75_Y-75..CD8T X73_Y-75..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          3.190872       2.775336       5.408168       2.540702 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       2.197225 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X76_Y-75..CD8T X77_Y-75..CD8T X76_Y-76..CD8T X78_Y-77..CD8T #> PDK4           0.000000       0.000000       0.000000              0 #> TNFRSF17       0.000000       0.000000       0.000000              0 #> ICAM3          1.522275       1.522275       3.344037              0 #> FAP            0.000000       0.000000       0.000000              0 #> GZMB           0.000000       0.000000       3.138587              0 #> TSC2           0.000000       0.000000       0.000000              0 #>          X77_Y-77..CD8T X76_Y-77..CD8T X77_Y-78..CD8T X74_Y-79..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.032958       0.000000       1.541691       0.000000 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.948353       2.569343       0.000000       5.453431 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X75_Y-77..CD8T X61_Y-67..CD8T X61_Y-68..CD8T X63_Y-70..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          6.099073       2.393944       3.829301       1.680811 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       2.144835       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X65_Y-70..CD8T X62_Y-71..CD8T X65_Y-71..CD8T X64_Y-71..CD8T #> PDK4           0.000000              0       0.000000       0.000000 #> TNFRSF17       0.000000              0       0.000000       0.000000 #> ICAM3          1.925955              0       1.925955       3.156336 #> FAP            0.000000              0       0.000000       0.000000 #> GZMB           0.000000              0       0.000000       0.000000 #> TSC2           0.000000              0       0.000000       0.000000 #>          X65_Y-72..CD8T X64_Y-72..CD8T X63_Y-72..CD8T X67_Y-73..CD8T #> PDK4          0.0000000      0.0000000              0       0.000000 #> TNFRSF17      0.0000000      0.0000000              0       0.000000 #> ICAM3         1.6282114      0.6465605              0       2.357021 #> FAP           0.0000000      0.0000000              0       0.000000 #> GZMB          0.7844143      0.0000000              0       1.093461 #> TSC2          0.0000000      0.0000000              0       0.630304 #>          X63_Y-69..CD8T X62_Y-69..CD8T X62_Y-72..CD8T X64_Y-73..CD8T #> PDK4                  0       0.000000              0              0 #> TNFRSF17              0       0.000000              0              0 #> ICAM3                 0       0.000000              0              0 #> FAP                   0       0.000000              0              0 #> GZMB                  0       4.900324              0              0 #> TSC2                  0       0.000000              0              0 #>          X66_Y-73..CD8T X65_Y-73..CD8T X64_Y-74..CD8T X65_Y-74..CD8T #> PDK4           0.000000              0       0.000000       0.000000 #> TNFRSF17       0.000000              0       0.000000       0.000000 #> ICAM3          1.444069              0       1.328326       0.000000 #> FAP            0.000000              0       0.000000       0.000000 #> GZMB           0.000000              0       2.476846       4.200369 #> TSC2           0.000000              0       0.000000       0.000000 #>          X66_Y-74..CD8T X65_Y-75..CD8T X64_Y-75..CD8T X67_Y-76..CD8T #> PDK4           0.000000       0.000000              0      0.0000000 #> TNFRSF17       0.000000       0.000000              0      0.0000000 #> ICAM3          2.217389       2.463577              0      2.4287779 #> FAP            0.000000       0.000000              0      0.0000000 #> GZMB           0.000000       2.687764              0      0.8696374 #> TSC2           0.000000       0.000000              0      0.0000000 #>          X64_Y-76..CD8T X63_Y-76..CD8T X66_Y-77..CD8T X60_Y-77..CD8T #> PDK4           0.000000              0      0.0000000       0.000000 #> TNFRSF17       0.000000              0      0.0000000       0.000000 #> ICAM3          4.378773              0      0.9461129       4.793809 #> FAP            0.000000              0      0.0000000       0.000000 #> GZMB           0.000000              0      0.0000000       0.000000 #> TSC2           0.000000              0      0.0000000       0.000000 #>          X63_Y-73..CD8T X62_Y-73..CD8T X62_Y-74..CD8T X66_Y-76..CD8T #> PDK4            0.00000       0.000000       0.000000              0 #> TNFRSF17        0.00000       0.000000       0.000000              0 #> ICAM3           0.00000       0.000000       0.000000              0 #> FAP             0.00000       0.000000       0.000000              0 #> GZMB            1.81781       3.298826       3.926936              0 #> TSC2            0.00000       0.000000       0.000000              0 #>          X67_Y-77..CD8T X63_Y-78..CD8T X73_Y-72..CD8T X72_Y-73..CD8T #> PDK4          0.0000000              0       0.000000      0.0000000 #> TNFRSF17      0.0000000              0       0.000000      0.0000000 #> ICAM3         2.1563316              0       1.640048      2.8518588 #> FAP           0.0000000              0       0.000000      0.0000000 #> GZMB          0.6200932              0       0.452080      1.4204279 #> TSC2          0.0000000              0       0.000000      0.4442889 #>          X68_Y-73..CD8T X71_Y-74..CD8T X72_Y-74..CD8T X67_Y-74..CD8T #> PDK4          0.0000000      0.0000000      0.0000000      0.0000000 #> TNFRSF17      0.0000000      0.0000000      0.0000000      0.0000000 #> ICAM3         0.7668074      2.0429491      2.2188250      1.4951361 #> FAP           0.0000000      0.0000000      0.0000000      0.0000000 #> GZMB          1.5653122      0.4983864      0.7073108      1.4155788 #> TSC2          1.0084864      0.4983864      0.0000000      0.5602702 #>          X68_Y-74..CD8T X69_Y-74..CD8T X67_Y-75..CD8T X69_Y-75..CD8T #> PDK4          0.0000000       0.000000       0.000000       0.000000 #> TNFRSF17      0.0000000       0.000000       0.000000       0.000000 #> ICAM3         2.7548555       2.964350       2.404904       3.120317 #> FAP           0.0000000       0.000000       0.000000       0.000000 #> GZMB          0.3905832       1.304315       1.042418       1.448688 #> TSC2          0.0000000       0.000000       0.000000       0.000000 #>          X71_Y-75..CD8T X68_Y-75..CD8T X72_Y-75..CD8T X70_Y-75..CD8T #> PDK4          0.0000000       0.000000      0.0000000      0.0000000 #> TNFRSF17      0.0000000       0.000000      0.0000000      0.0000000 #> ICAM3         1.9921136       3.797324      1.5087171      2.9721683 #> FAP           0.0000000       0.000000      0.0000000      0.0000000 #> GZMB          0.8263349       0.556925      0.7475796      1.4892872 #> TSC2          0.3737898       0.000000      0.7475796      0.4268613 #>          X70_Y-76..CD8T X69_Y-76..CD8T X68_Y-76..CD8T X71_Y-76..CD8T #> PDK4          0.0000000       0.000000      0.0000000       0.000000 #> TNFRSF17      0.0000000       0.000000      0.0000000       0.000000 #> ICAM3         2.7347365       3.068402      3.3006275       3.302682 #> FAP           0.0000000       0.000000      0.0000000       0.000000 #> GZMB          2.2685281       1.031136      0.9698781       1.943210 #> TSC2          0.3557178       0.000000      0.3275613       0.000000 #>          X68_Y-77..CD8T X70_Y-77..CD8T X69_Y-77..CD8T X71_Y-77..CD8T #> PDK4          0.0000000        0.00000      0.0000000              0 #> TNFRSF17      0.0000000        0.00000      0.0000000              0 #> ICAM3         3.4417921        1.23044      2.8369101              0 #> FAP           0.0000000        0.00000      0.0000000              0 #> GZMB          1.5301743        0.00000      1.2598488              0 #> TSC2          0.3821549        0.00000      0.5445375              0 #>          X69_Y-78..CD8T X70_Y-78..CD8T X72_Y-78..CD8T X71_Y-78..CD8T #> PDK4          0.0000000      0.0000000       0.000000       0.000000 #> TNFRSF17      0.0000000      0.0000000       0.000000       0.000000 #> ICAM3         3.3440310      2.3188107       2.322641       4.599839 #> FAP           0.0000000      0.0000000       0.000000       0.000000 #> GZMB          0.7913279      0.6303040       0.000000       3.691381 #> TSC2          0.8529123      0.5502978       0.000000       0.000000 #>          X72_Y-79..CD8T X68_Y-79..CD8T X72_Y-76..CD8T X68_Y-78..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.322641       1.420565       2.666807       2.632142 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       2.288148 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X71_Y-79..CD8T X57_Y-75..CD8T X54_Y-75..CD8T X55_Y-77..CD8T #> PDK4          0.0000000       0.000000       0.000000      0.0000000 #> TNFRSF17      0.0000000       0.000000       0.000000      0.0000000 #> ICAM3         3.2570913       2.297758       1.704576      2.6739967 #> FAP           0.0000000       0.000000       0.000000      0.0000000 #> GZMB          3.3993232       2.843687       3.066564      0.5602959 #> TSC2          0.7759244       0.000000       0.000000      0.0000000 #>          X54_Y-77..CD8T X55_Y-78..CD8T X54_Y-79..CD8T X55_Y-79..CD8T #> PDK4           0.000000      0.0000000      0.0000000       0.000000 #> TNFRSF17       0.000000      0.0000000      0.0000000       0.000000 #> ICAM3          2.646368      1.8516351      2.7515059       1.040855 #> FAP            0.000000      0.0000000      0.0000000       0.000000 #> GZMB           1.662488      0.7184749      1.1520843       0.000000 #> TSC2           0.000000      0.0000000      0.3437141       0.000000 #>          X56_Y-79..CD8T X55_Y-75..CD8T X54_Y-76..CD8T X54_Y-78..CD8T #> PDK4           0.000000       0.000000      0.0000000      0.0000000 #> TNFRSF17       0.000000       0.000000      0.0000000      0.0000000 #> ICAM3          1.387807       5.293404      2.4952312      2.9393540 #> FAP            0.000000       0.000000      0.0000000      0.0000000 #> GZMB           0.000000       4.605269      0.6419852      0.3922071 #> TSC2           0.000000       0.000000      0.0000000      0.0000000 #>          X73_Y-66..CD8T X68_Y-67..CD8T X73_Y-68..CD8T X68_Y-68..CD8T #> PDK4           0.000000      0.0000000       0.000000       0.000000 #> TNFRSF17       0.000000      0.0000000       0.000000       0.000000 #> ICAM3          2.671707      1.1464647       1.858254       1.356178 #> FAP            0.000000      0.0000000       0.000000       0.000000 #> GZMB           1.470474      0.0000000       1.252686       1.356178 #> TSC2           0.000000      0.9757137       0.000000       1.172299 #>          X69_Y-68..CD8T X72_Y-69..CD8T X68_Y-69..CD8T X73_Y-69..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          1.356178       4.860139       1.088931       2.860219 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           1.356178       5.202882       2.179822       2.552675 #> TSC2           1.172299       0.000000       0.000000       0.000000 #>          X69_Y-69..CD8T X71_Y-70..CD8T X68_Y-70..CD8T X69_Y-70..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          3.057255       4.768901       0.000000       1.736164 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       2.087982       5.014111       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X73_Y-70..CD8T X67_Y-70..CD8T X73_Y-71..CD8T X70_Y-71..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          4.178846       2.521216       2.064839       5.208492 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       4.998584       1.564425       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X72_Y-71..CD8T X67_Y-71..CD8T X72_Y-72..CD8T X71_Y-73..CD8T #> PDK4           0.000000              0       0.000000       0.000000 #> TNFRSF17       0.000000              0       0.000000       0.000000 #> ICAM3          1.996284              0       2.396339       2.298401 #> FAP            0.000000              0       0.000000       0.000000 #> GZMB           1.611351              0       2.404436       2.418805 #> TSC2           0.000000              0       0.000000       0.000000 #>          X69_Y-66..CD8T X67_Y-67..CD8T X72_Y-68..CD8T X71_Y-69..CD8T #> PDK4                  0       0.000000       0.000000       0.000000 #> TNFRSF17              0       0.000000       0.000000       0.000000 #> ICAM3                 0       1.528620       1.985406       4.814520 #> FAP                   0       0.000000       0.000000       0.000000 #> GZMB                  0       0.000000       2.803550       3.645432 #> TSC2                  0       1.300952       0.000000       0.000000 #>          X72_Y-70..CD8T X70_Y-70..CD8T X49_Y-72..CD8T X52_Y-73..CD8T #> PDK4           0.000000       0.000000       0.000000      0.0000000 #> TNFRSF17       0.000000       0.000000       0.000000      0.0000000 #> ICAM3          3.003428       2.604246       2.902173      4.6466942 #> FAP            0.000000       0.000000       0.000000      0.0000000 #> GZMB           1.131958       1.923706       2.593947      0.8376117 #> TSC2           0.000000       0.000000       0.000000      0.0000000 #>          X50_Y-73..CD8T X48_Y-74..CD8T X54_Y-74..CD8T X51_Y-74..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.982651       1.597077       2.359745       2.903613 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           3.119573       2.268913       2.193290       1.623449 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X52_Y-74..CD8T X50_Y-74..CD8T X53_Y-74..CD8T X52_Y-75..CD8T #> PDK4           0.000000      0.0000000       0.000000       0.000000 #> TNFRSF17       0.000000      0.0000000       0.000000       0.000000 #> ICAM3          2.931699      1.0976266       1.616756       2.419815 #> FAP            0.000000      0.0000000       0.000000       0.000000 #> GZMB           2.153573      0.9274194       2.746963       3.834021 #> TSC2           0.000000      0.0000000       0.000000       0.000000 #>          X53_Y-75..CD8T X53_Y-76..CD8T X53_Y-77..CD8T X52_Y-77..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          1.979849       1.993688       2.211148       2.234142 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           3.563991       2.091131       3.057047       2.595287 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X48_Y-77..CD8T X49_Y-77..CD8T X50_Y-77..CD8T X49_Y-78..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.032909       1.183571       1.578095       2.484391 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           1.021408       2.235436       2.980582       1.392216 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X53_Y-78..CD8T X51_Y-78..CD8T X52_Y-78..CD8T X48_Y-78..CD8T #> PDK4           0.000000      0.0000000      0.0000000       0.000000 #> TNFRSF17       0.000000      0.0000000      0.0000000       0.000000 #> ICAM3          3.970002      1.2983756      1.0229988       1.665422 #> FAP            0.000000      0.0000000      0.0000000       0.000000 #> GZMB           1.163684      3.5213572      3.1516168       0.510704 #> TSC2           0.000000      0.3617165      0.4521457       0.000000 #>          X50_Y-79..CD8T X52_Y-79..CD8T X53_Y-79..CD8T X49_Y-79..CD8T #> PDK4          0.0000000       0.000000       0.000000      0.0000000 #> TNFRSF17      0.0000000       0.000000       0.000000      0.0000000 #> ICAM3         3.2625132       1.606956       2.849689      4.4027769 #> FAP           0.0000000       0.000000       0.000000      0.0000000 #> GZMB          0.8702735       1.027986       1.427712      0.4612267 #> TSC2          0.3914913       0.000000       0.000000      0.5654874 #>          X49_Y-73..CD8T X51_Y-73..CD8T X49_Y-74..CD8T X44_Y-91..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          0.000000       3.098505       2.982651       3.358216 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           3.891221       1.610591       3.119573       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X48_Y-91..CD8T X48_Y-92..CD8T X47_Y-92..CD8T X46_Y-92..CD8T #> PDK4           0.000000      0.0000000      0.0000000      0.0000000 #> TNFRSF17       0.000000      0.0000000      0.0000000      0.0000000 #> ICAM3          4.261882      2.8526660      2.7514299      2.6400312 #> FAP            0.000000      0.0000000      0.0000000      0.0000000 #> GZMB           1.361057      0.8394405      0.6616755      0.6616755 #> TSC2           0.000000      0.0000000      0.0000000      0.0000000 #>          X44_Y-92..CD8T X43_Y-92..CD8T X47_Y-93..CD8T X46_Y-93..CD8T #> PDK4           0.000000        0.00000       0.000000       0.000000 #> TNFRSF17       0.000000        0.00000       0.000000       0.000000 #> ICAM3          2.858564        4.97594       3.483684       2.908412 #> FAP            0.000000        0.00000       0.000000       0.000000 #> GZMB           0.000000        0.00000       1.058681       0.000000 #> TSC2           0.000000        0.00000       0.000000       0.000000 #>          X45_Y-93..CD8T X45_Y-94..CD8T X46_Y-94..CD8T X46_Y-95..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.297758       1.226361       3.092300       2.554068 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       1.453175       1.316586       2.547080 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X44_Y-95..CD8T X47_Y-95..CD8T X48_Y-95..CD8T X45_Y-96..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          5.386288       2.177156       4.354312       1.063138 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X44_Y-96..CD8T X47_Y-96..CD8T X44_Y-97..CD8T X46_Y-97..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          5.226742       2.604246       5.760338       4.459799 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       2.949450       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X45_Y-91..CD8T X45_Y-92..CD8T X47_Y-94..CD8T X24_Y-76..CD8T #> PDK4           0.000000              0       0.000000       0.000000 #> TNFRSF17       0.000000              0       0.000000       0.000000 #> ICAM3          2.292929              0       0.000000       5.019766 #> FAP            0.000000              0       0.000000       0.000000 #> GZMB           2.393944              0       1.886162       0.000000 #> TSC2           2.051518              0       0.000000       0.000000 #>          X33_Y-71..CD8T X30_Y-72..CD8T X36_Y-80..CD8T X21_Y-66..CD8T #> PDK4           0.000000       0.000000       0.000000              0 #> TNFRSF17       0.000000       0.000000       0.000000              0 #> ICAM3          5.050104       4.221184       4.865342              0 #> FAP            0.000000       0.000000       0.000000              0 #> GZMB           0.000000       0.000000       2.189387              0 #> TSC2           0.000000       0.000000       0.000000              0 #>          X25_Y-70..CD8T X26_Y-72..CD8T X46_Y-65..CD8T X43_Y-65..CD8T #> PDK4           0.000000        0.00000       0.000000       0.000000 #> TNFRSF17       0.000000        0.00000       0.000000       0.000000 #> ICAM3          4.402383        4.71949       4.355722       4.340652 #> FAP            0.000000        0.00000       0.000000       0.000000 #> GZMB           4.402383        0.00000       0.000000       5.027264 #> TSC2           0.000000        0.00000       0.000000       0.000000 #>          X47_Y-66..CD8T X45_Y-66..CD8T X46_Y-67..CD8T X46_Y-66..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          5.042432       4.812979       3.013379       2.382278 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X54_Y-64..CD8T X48_Y-64..CD8T X53_Y-64..CD8T X54_Y-65..CD8T #> PDK4           0.000000              0      0.0000000       0.000000 #> TNFRSF17       0.000000              0      0.0000000       0.000000 #> ICAM3          2.954698              0      2.2544884       2.416070 #> FAP            0.000000              0      0.0000000       0.000000 #> GZMB           1.829717              0      0.6138275       1.400037 #> TSC2           0.000000              0      0.0000000       0.000000 #>          X52_Y-65..CD8T X53_Y-65..CD8T X51_Y-66..CD8T X52_Y-66..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.081694       2.708072       4.116978       3.109905 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.596098       0.878334       0.000000       1.489232 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X54_Y-66..CD8T X52_Y-64..CD8T X51_Y-65..CD8T X48_Y-65..CD8T #> PDK4           0.000000       0.000000       0.000000              0 #> TNFRSF17       0.000000       0.000000       0.000000              0 #> ICAM3          4.324836       3.122541       3.971361              0 #> FAP            0.000000       0.000000       0.000000              0 #> GZMB           0.000000       0.894147       0.000000              0 #> TSC2           0.000000       0.000000       0.000000              0 #>          X37_Y-79..CD8T X37_Y-82..CD8T X42_Y-82..CD8T X42_Y-83..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          4.590686       4.730565       5.488788       5.077353 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           2.450162       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X37_Y-83..CD8T X37_Y-84..CD8T X44_Y-73..CD8T X48_Y-73..CD8T #> PDK4           0.000000              0       0.000000      0.0000000 #> TNFRSF17       0.000000              0       0.000000      0.0000000 #> ICAM3          2.446865              0       4.443047      2.1631170 #> FAP            0.000000              0       0.000000      0.0000000 #> GZMB           0.000000              0       0.000000      3.6720049 #> TSC2           0.000000              0       0.000000      0.5542305 #>          X47_Y-73..CD8T X43_Y-74..CD8T X46_Y-74..CD8T X47_Y-74..CD8T #> PDK4          0.0000000              0       0.000000       0.000000 #> TNFRSF17      0.0000000              0       0.000000       0.000000 #> ICAM3         3.1442880              0       5.266346       2.161914 #> FAP           0.0000000              0       0.000000       0.000000 #> GZMB          1.6484800              0       0.000000       1.342973 #> TSC2          0.3325383              0       0.000000       0.000000 #>          X45_Y-75..CD8T X47_Y-75..CD8T X46_Y-75..CD8T X47_Y-76..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          5.770386       1.235788       2.088098       3.401927 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       1.354731       1.036934       2.137961 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X46_Y-76..CD8T X45_Y-76..CD8T X48_Y-76..CD8T X47_Y-77..CD8T #> PDK4           0.000000        0.00000       0.000000       0.000000 #> TNFRSF17       0.000000        0.00000       0.000000       0.000000 #> ICAM3          3.099737        5.34116       3.722842       2.251754 #> FAP            0.000000        0.00000       0.000000       0.000000 #> GZMB           0.000000        0.00000       2.748807       1.512804 #> TSC2           0.000000        0.00000       0.000000       0.000000 #>          X45_Y-78..CD8T X46_Y-78..CD8T X48_Y-79..CD8T X47_Y-78..CD8T #> PDK4           0.000000       0.000000       0.000000              0 #> TNFRSF17       0.000000       0.000000       0.000000              0 #> ICAM3          2.573573       2.573573       2.207712              0 #> FAP            0.000000       0.000000       0.000000              0 #> GZMB           2.229899       2.229899       0.000000              0 #> TSC2           0.000000       0.000000       0.000000              0 #>          X77_Y-80..CD8T X76_Y-80..CD8T X78_Y-81..CD8T X78_Y-82..CD8T #> PDK4           0.000000              0        0.00000      0.0000000 #> TNFRSF17       0.000000              0        0.00000      0.0000000 #> ICAM3          5.012325              0        1.24047      1.2918651 #> FAP            0.000000              0        0.00000      0.0000000 #> GZMB           0.000000              0        1.24047      0.6202348 #> TSC2           0.000000              0        0.00000      0.0000000 #>          X78_Y-83..CD8T X77_Y-84..CD8T X75_Y-84..CD8T X75_Y-79..CD8T #> PDK4          0.0000000              0              0              0 #> TNFRSF17      0.0000000              0              0              0 #> ICAM3         1.8571313              0              0              0 #> FAP           0.0000000              0              0              0 #> GZMB          0.9995219              0              0              0 #> TSC2          0.0000000              0              0              0 #>          X77_Y-81..CD8T X77_Y-83..CD8T X72_Y-67..CD8T X78_Y-67..CD8T #> PDK4                  0       0.000000       0.000000       0.000000 #> TNFRSF17              0       0.000000       0.000000       0.000000 #> ICAM3                 0       2.223435       2.715443       2.762726 #> FAP                   0       0.000000       0.000000       0.000000 #> GZMB                  0       1.566950       0.000000       0.000000 #> TSC2                  0       0.000000       0.000000       0.000000 #>          X74_Y-67..CD8T X75_Y-67..CD8T X76_Y-68..CD8T X74_Y-68..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          3.383285       2.775336       2.780313       3.508941 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           3.153710       0.000000       2.941691       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X77_Y-68..CD8T X76_Y-69..CD8T X77_Y-69..CD8T X78_Y-69..CD8T #> PDK4                  0       0.000000              0              0 #> TNFRSF17              0       0.000000              0              0 #> ICAM3                 0       0.000000              0              0 #> FAP                   0       0.000000              0              0 #> GZMB                  0       2.569343              0              0 #> TSC2                  0       0.000000              0              0 #>          X74_Y-69..CD8T X75_Y-69..CD8T X78_Y-70..CD8T X74_Y-70..CD8T #> PDK4           0.000000       0.000000       0.000000        0.00000 #> TNFRSF17       0.000000       0.000000       0.000000        0.00000 #> ICAM3          1.895791       1.272347       1.308999        2.78642 #> FAP            0.000000       0.000000       0.000000        0.00000 #> GZMB           1.665870       0.000000       0.000000        0.00000 #> TSC2           0.000000       0.000000       0.000000        0.00000 #>          X74_Y-71..CD8T X77_Y-71..CD8T X78_Y-72..CD8T X77_Y-72..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          6.132899       4.858501       2.470424       3.239001 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           4.753095       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X76_Y-66..CD8T X75_Y-68..CD8T X57_Y-66..CD8T X58_Y-66..CD8T #> PDK4           0.000000      0.0000000       0.000000       0.000000 #> TNFRSF17       0.000000      0.0000000       0.000000       0.000000 #> ICAM3          5.226742      3.0951601       2.036917       2.679548 #> FAP            0.000000      0.0000000       0.000000       0.000000 #> GZMB           0.000000      0.7160465       2.502229       1.283725 #> TSC2           0.000000      0.0000000       0.000000       0.000000 #>          X58_Y-67..CD8T X59_Y-67..CD8T X56_Y-67..CD8T X57_Y-67..CD8T #> PDK4          0.0000000        0.00000       0.000000      0.0000000 #> TNFRSF17      0.0000000        0.00000       0.000000      0.0000000 #> ICAM3         1.9291124        2.71528       3.278579      2.8124996 #> FAP           0.0000000        0.00000       0.000000      0.0000000 #> GZMB          0.6981683        0.00000       0.000000      0.9831132 #> TSC2          0.0000000        0.00000       0.000000      0.0000000 #>          X60_Y-67..CD8T X57_Y-68..CD8T X60_Y-68..CD8T X58_Y-68..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          1.965913       2.687769       2.762516       1.301507 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       1.887273       0.000000       1.176897 #> TSC2           2.130847       0.000000       1.420565       0.000000 #>          X57_Y-69..CD8T X59_Y-69..CD8T X59_Y-70..CD8T X58_Y-70..CD8T #> PDK4          0.0000000      0.0000000       0.000000       0.000000 #> TNFRSF17      0.0000000      0.0000000       0.000000       0.000000 #> ICAM3         0.8564476      0.8229633       1.028704       4.663002 #> FAP           0.0000000      0.0000000       0.000000       0.000000 #> GZMB          1.3730471      0.8622388       0.000000       0.000000 #> TSC2          0.0000000      0.0000000       0.000000       0.000000 #>          X60_Y-71..CD8T X59_Y-71..CD8T X54_Y-68..CD8T X58_Y-69..CD8T #> PDK4                  0              0              0      0.0000000 #> TNFRSF17              0              0              0      0.0000000 #> ICAM3                 0              0              0      0.8564476 #> FAP                   0              0              0      0.0000000 #> GZMB                  0              0              0      2.0915794 #> TSC2                  0              0              0      0.0000000 #>          X57_Y-70..CD8T X60_Y-70..CD8T X58_Y-71..CD8T X43_Y-79..CD8T #> PDK4           0.000000              0       0.000000       0.000000 #> TNFRSF17       0.000000              0       0.000000       0.000000 #> ICAM3          4.663002              0       5.697193       4.363345 #> FAP            0.000000              0       0.000000       0.000000 #> GZMB           0.000000              0       0.000000       5.050104 #> TSC2           0.000000              0       0.000000       0.000000 #>          X47_Y-79..CD8T X45_Y-79..CD8T X46_Y-79..CD8T X47_Y-80..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.474852       4.502979       1.715716       1.754761 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       1.486600       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X45_Y-80..CD8T X46_Y-80..CD8T X46_Y-81..CD8T X45_Y-81..CD8T #> PDK4                  0      0.0000000      0.0000000       0.000000 #> TNFRSF17              0      0.0000000      0.0000000       0.000000 #> ICAM3                 0      2.7902989      3.6781488       2.331095 #> FAP                   0      0.0000000      0.0000000       0.000000 #> GZMB                  0      0.6726485      0.5504289       0.000000 #> TSC2                  0      0.0000000      0.0000000       0.000000 #>          X44_Y-81..CD8T X47_Y-81..CD8T X45_Y-82..CD8T X44_Y-82..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.338433       1.536039       2.760323       3.288513 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       1.565736       1.882359       1.592051 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X47_Y-82..CD8T X46_Y-82..CD8T X43_Y-82..CD8T X45_Y-83..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.260643       2.780489       2.388077       1.589603 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           1.788609       2.739967       2.388077       1.858139 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X43_Y-83..CD8T X46_Y-83..CD8T X44_Y-83..CD8T X44_Y-84..CD8T #> PDK4           0.000000      0.0000000       0.000000      0.0000000 #> TNFRSF17       0.000000      0.0000000       0.000000      0.0000000 #> ICAM3          1.910782      0.9733472       4.391410      3.1686804 #> FAP            0.000000      0.0000000       0.000000      0.0000000 #> GZMB           0.000000      3.1541527       1.212349      1.4528906 #> TSC2           0.000000      0.0000000       0.000000      0.4030235 #>          X45_Y-84..CD8T X46_Y-84..CD8T X43_Y-84..CD8T X47_Y-84..CD8T #> PDK4          0.0000000       0.000000      0.0000000       0.000000 #> TNFRSF17      0.0000000       0.000000      0.0000000       0.000000 #> ICAM3         0.6948307       2.403642      2.8443812       4.470883 #> FAP           0.0000000       0.000000      0.0000000       0.000000 #> GZMB          1.4920869       1.894971      0.0000000       2.034268 #> TSC2          0.0000000       0.000000      0.9672564       2.034268 #>          X45_Y-85..CD8T X46_Y-85..CD8T X44_Y-85..CD8T X44_Y-79..CD8T #> PDK4          0.0000000      0.0000000       0.000000       0.000000 #> TNFRSF17      0.0000000      0.0000000       0.000000       0.000000 #> ICAM3         1.3758694      1.6341596       1.508529       5.747799 #> FAP           0.0000000      0.0000000       0.000000       0.000000 #> GZMB          2.2163468      0.8070447       1.533803       0.000000 #> TSC2          0.3111072      0.0000000       0.000000       0.000000 #>          X47_Y-83..CD8T X47_Y-85..CD8T X48_Y-85..CD8T X55_Y-91..CD8T #> PDK4           0.000000       0.000000       0.000000      0.0000000 #> TNFRSF17       0.000000       0.000000       0.000000      0.0000000 #> ICAM3          1.555306       1.114950       1.812116      3.2962388 #> FAP            0.000000       0.000000       0.000000      0.0000000 #> GZMB           3.110612       2.249687       1.464110      0.7708453 #> TSC2           0.000000       0.000000       0.000000      0.0000000 #>          X50_Y-91..CD8T X49_Y-91..CD8T X51_Y-92..CD8T X52_Y-92..CD8T #> PDK4           0.000000       0.000000       0.000000        0.00000 #> TNFRSF17       0.000000       0.000000       0.000000        0.00000 #> ICAM3          2.723682       2.758973       3.255426        1.28892 #> FAP            0.000000       0.000000       0.000000        0.00000 #> GZMB           0.000000       0.000000       2.206654        0.00000 #> TSC2           0.000000       0.000000       0.000000        0.00000 #>          X53_Y-92..CD8T X50_Y-92..CD8T X49_Y-92..CD8T X53_Y-93..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.661704       3.418446       3.015213       4.128237 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       3.541145       1.599463       1.216147 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X48_Y-94..CD8T X53_Y-94..CD8T X51_Y-94..CD8T X54_Y-95..CD8T #> PDK4            0.00000              0       0.000000              0 #> TNFRSF17        0.00000              0       0.000000              0 #> ICAM3           3.94168              0       2.078606              0 #> FAP             0.00000              0       0.000000              0 #> GZMB            3.94168              0       0.000000              0 #> TSC2            0.00000              0       0.000000              0 #>          X53_Y-95..CD8T X52_Y-96..CD8T X51_Y-96..CD8T X49_Y-96..CD8T #> PDK4                  0       0.000000       0.000000       0.000000 #> TNFRSF17              0       0.000000       0.000000       0.000000 #> ICAM3                 0       2.723424       2.170326       0.000000 #> FAP                   0       0.000000       0.000000       0.000000 #> GZMB                  0       0.000000       0.000000       4.307573 #> TSC2                  0       0.000000       0.000000       0.000000 #>          X51_Y-97..CD8T X52_Y-93..CD8T X52_Y-95..CD8T X70_Y-79..CD8T #> PDK4           0.000000       0.000000              0       0.000000 #> TNFRSF17       0.000000       0.000000              0       0.000000 #> ICAM3          0.000000       1.750587              0       2.370420 #> FAP            0.000000       0.000000              0       0.000000 #> GZMB           5.089387       2.432293              0       1.778808 #> TSC2           0.000000       0.000000              0       0.000000 #>          X69_Y-79..CD8T X71_Y-80..CD8T X68_Y-80..CD8T X68_Y-81..CD8T #> PDK4           0.000000      0.0000000              0       0.000000 #> TNFRSF17       0.000000      0.0000000              0       0.000000 #> ICAM3          4.132759      1.5002671              0       1.849044 #> FAP            0.000000      0.0000000              0       0.000000 #> GZMB           5.220621      2.8086359              0       0.000000 #> TSC2           0.000000      0.7611375              0       0.000000 #>          X71_Y-81..CD8T X72_Y-82..CD8T X71_Y-82..CD8T X70_Y-83..CD8T #> PDK4          0.0000000              0       0.000000      0.0000000 #> TNFRSF17      0.0000000              0       0.000000      0.0000000 #> ICAM3         2.9065061              0       1.389577      3.1023242 #> FAP           0.0000000              0       0.000000      0.0000000 #> GZMB          2.7364451              0       0.000000      0.8289268 #> TSC2          0.7611375              0       0.000000      0.0000000 #>          X71_Y-83..CD8T X67_Y-83..CD8T X72_Y-83..CD8T X68_Y-83..CD8T #> PDK4           0.000000      0.0000000              0       0.000000 #> TNFRSF17       0.000000      0.0000000              0       0.000000 #> ICAM3          1.701849      3.6653027              0       2.941048 #> FAP            0.000000      0.0000000              0       0.000000 #> GZMB           0.000000      3.7975515              0       3.097077 #> TSC2           0.000000      0.4915409              0       1.454448 #>          X69_Y-84..CD8T X67_Y-84..CD8T X68_Y-84..CD8T X67_Y-85..CD8T #> PDK4          0.0000000      0.0000000       0.000000      0.0000000 #> TNFRSF17      0.0000000      0.0000000       0.000000      0.0000000 #> ICAM3         2.6770466      2.8938359       2.640429      0.9466345 #> FAP           0.0000000      0.0000000       0.000000      0.0000000 #> GZMB          0.9311093      2.9235222       2.604722      0.0000000 #> TSC2          0.0000000      0.5390712       0.000000      0.0000000 #>          X68_Y-85..CD8T X70_Y-80..CD8T X70_Y-84..CD8T X52_Y-67..CD8T #> PDK4          0.0000000       0.000000       0.000000      0.0000000 #> TNFRSF17      0.0000000       0.000000       0.000000      0.0000000 #> ICAM3         3.3722347       1.673255       2.808479      2.3628909 #> FAP           0.0000000       0.000000       0.000000      0.0000000 #> GZMB          0.6650781       1.980712       0.000000      0.7902942 #> TSC2          0.0000000       0.000000       0.000000      0.0000000 #>          X53_Y-67..CD8T X51_Y-67..CD8T X51_Y-68..CD8T X52_Y-68..CD8T #> PDK4                  0      0.0000000       0.000000       0.000000 #> TNFRSF17              0      0.0000000       0.000000       0.000000 #> ICAM3                 0      2.3383974       2.069306       3.621084 #> FAP                   0      0.0000000       0.000000       0.000000 #> GZMB                  0      0.5927206       0.000000       1.338587 #> TSC2                  0      0.0000000       0.000000       0.000000 #>          X49_Y-68..CD8T X51_Y-69..CD8T X52_Y-69..CD8T X50_Y-70..CD8T #> PDK4           0.000000      0.0000000       0.000000       0.000000 #> TNFRSF17       0.000000      0.0000000       0.000000       0.000000 #> ICAM3          4.913648      3.0705845       2.288216       2.699821 #> FAP            0.000000      0.0000000       0.000000       0.000000 #> GZMB           0.000000      0.7109218       1.485131       3.255025 #> TSC2           0.000000      0.0000000       0.000000       0.000000 #>          X52_Y-70..CD8T X51_Y-70..CD8T X49_Y-70..CD8T X53_Y-70..CD8T #> PDK4          0.0000000       0.000000       0.000000       0.000000 #> TNFRSF17      0.0000000       0.000000       0.000000       0.000000 #> ICAM3         0.5828149       2.139732       2.315204       2.004158 #> FAP           0.0000000       0.000000       0.000000       0.000000 #> GZMB          1.6758616       2.902072       1.284671       4.483961 #> TSC2          0.0000000       0.000000       0.000000       0.000000 #>          X48_Y-71..CD8T X52_Y-71..CD8T X51_Y-71..CD8T X49_Y-71..CD8T #> PDK4           0.000000      0.0000000      0.0000000       0.000000 #> TNFRSF17       0.000000      0.0000000      0.0000000       0.000000 #> ICAM3          2.197123      2.4309600      2.7650130       2.823799 #> FAP            0.000000      0.0000000      0.0000000       0.000000 #> GZMB           3.134463      1.2468594      1.6768192       4.063766 #> TSC2           0.000000      0.4140684      0.5520912       0.000000 #>          X52_Y-72..CD8T X53_Y-72..CD8T X51_Y-72..CD8T X50_Y-72..CD8T #> PDK4           0.000000       0.000000       0.000000              0 #> TNFRSF17       0.000000       0.000000       0.000000              0 #> ICAM3          2.730292       2.033394       1.588185              0 #> FAP            0.000000       0.000000       0.000000              0 #> GZMB           1.331154       1.694196       0.000000              0 #> TSC2           0.000000       0.000000       0.000000              0 #>          X50_Y-69..CD8T X48_Y-70..CD8T X63_Y-65..CD8T X64_Y-65..CD8T #> PDK4           0.000000      0.0000000       0.000000       0.000000 #> TNFRSF17       0.000000      0.0000000       0.000000       0.000000 #> ICAM3          1.599922      1.1513173       4.529834       2.004158 #> FAP            0.000000      0.0000000       0.000000       0.000000 #> GZMB           1.599922      0.9373394       0.000000       2.004158 #> TSC2           0.000000      0.0000000       0.000000       2.288148 #>          X65_Y-65..CD8T X66_Y-65..CD8T X64_Y-64..CD8T X56_Y-80..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          1.336105       1.850224       2.004158       2.520515 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           2.849089       0.000000       2.004158       1.123547 #> TSC2           0.000000       0.000000       2.288148       0.000000 #>          X59_Y-80..CD8T X58_Y-80..CD8T X55_Y-80..CD8T X57_Y-80..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          1.429890       3.030143       2.127412       3.479319 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           1.396223       0.000000       0.000000       1.209070 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X57_Y-81..CD8T X58_Y-81..CD8T X60_Y-81..CD8T X59_Y-81..CD8T #> PDK4           0.000000      0.0000000      0.0000000      0.0000000 #> TNFRSF17       0.000000      0.0000000      0.0000000      0.0000000 #> ICAM3          1.728092      1.5533851      2.3603774      2.2915501 #> FAP            0.000000      0.0000000      0.0000000      0.0000000 #> GZMB           1.834017      0.7595459      1.5571683      0.6415187 #> TSC2           0.000000      0.0000000      0.7759244      0.3103698 #>          X55_Y-81..CD8T X54_Y-81..CD8T X59_Y-82..CD8T X55_Y-82..CD8T #> PDK4           0.000000      0.0000000       0.000000       0.000000 #> TNFRSF17       0.000000      0.0000000       0.000000       0.000000 #> ICAM3          2.383321      0.7272242       3.697127       2.437488 #> FAP            0.000000      0.0000000       0.000000       0.000000 #> GZMB           1.387668      0.0000000       1.256816       1.210643 #> TSC2           0.000000      0.0000000       0.000000       0.000000 #>          X58_Y-82..CD8T X56_Y-82..CD8T X54_Y-82..CD8T X60_Y-82..CD8T #> PDK4          0.0000000       0.000000       0.000000              0 #> TNFRSF17      0.0000000       0.000000       0.000000              0 #> ICAM3         1.7116118       2.622667       2.921911              0 #> FAP           0.0000000       0.000000       0.000000              0 #> GZMB          0.5744395       0.000000       1.132774              0 #> TSC2          0.0000000       0.000000       0.000000              0 #>          X57_Y-82..CD8T X55_Y-83..CD8T X54_Y-83..CD8T X57_Y-83..CD8T #> PDK4                  0      0.0000000      0.0000000              0 #> TNFRSF17              0      0.0000000      0.0000000              0 #> ICAM3                 0      1.9893203      3.0971428              0 #> FAP                   0      0.0000000      0.0000000              0 #> GZMB                  0      0.6518137      0.5398094              0 #> TSC2                  0      0.0000000      0.5708532              0 #>          X58_Y-83..CD8T X55_Y-84..CD8T X58_Y-84..CD8T X57_Y-84..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          3.273628       2.161727       2.984325       2.131529 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           1.872224       0.874862       2.344149       2.655346 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X59_Y-84..CD8T X59_Y-85..CD8T X58_Y-85..CD8T X54_Y-85..CD8T #> PDK4          0.0000000      0.0000000        0.00000      0.0000000 #> TNFRSF17      0.0000000      0.0000000        0.00000      0.0000000 #> ICAM3         1.7602219      2.3594766        2.33273      1.1804230 #> FAP           0.0000000      0.0000000        0.00000      0.0000000 #> GZMB          1.7467514      2.4067236        1.10834      0.3268783 #> TSC2          0.3745314      0.2203126        0.00000      0.3191631 #>          X57_Y-85..CD8T X55_Y-85..CD8T X56_Y-85..CD8T X60_Y-85..CD8T #> PDK4           0.000000      0.0000000      0.0000000       0.000000 #> TNFRSF17       0.000000      0.0000000      0.0000000       0.000000 #> ICAM3          1.474908      1.4223983      2.7372745       3.267923 #> FAP            0.000000      0.0000000      0.0000000       0.000000 #> GZMB           1.842186      0.2664608      0.8057099       1.761261 #> TSC2           0.000000      0.2628402      0.0000000       0.000000 #>          X57_Y-79..CD8T X54_Y-80..CD8T X56_Y-83..CD8T X61_Y-81..CD8T #> PDK4           0.000000       0.000000              0              0 #> TNFRSF17       0.000000       0.000000              0              0 #> ICAM3          1.727245       1.721173              0              0 #> FAP            0.000000       0.000000              0              0 #> GZMB           2.981859       1.546650              0              0 #> TSC2           0.000000       0.000000              0              0 #>          X61_Y-82..CD8T X63_Y-82..CD8T X60_Y-83..CD8T X63_Y-83..CD8T #> PDK4            0.00000       0.000000       0.000000      0.0000000 #> TNFRSF17        0.00000       0.000000       0.000000      0.0000000 #> ICAM3           0.00000       1.407061       0.000000      1.6976798 #> FAP             0.00000       0.000000       0.000000      0.0000000 #> GZMB            5.24357       0.000000       2.225693      1.7241100 #> TSC2            0.00000       0.000000       0.000000      0.2544595 #>          X61_Y-83..CD8T X62_Y-83..CD8T X65_Y-83..CD8T X62_Y-84..CD8T #> PDK4           0.000000       0.000000       0.000000      0.0000000 #> TNFRSF17       0.000000       0.000000       0.000000      0.0000000 #> ICAM3          1.999907       2.610942       2.456824      1.7160673 #> FAP            0.000000       0.000000       0.000000      0.0000000 #> GZMB           2.752518       0.845581       2.586486      0.8614808 #> TSC2           0.000000       0.000000       0.000000      0.0000000 #>          X63_Y-84..CD8T X64_Y-84..CD8T X65_Y-84..CD8T X64_Y-85..CD8T #> PDK4          0.0000000      0.0000000      0.0000000       0.000000 #> TNFRSF17      0.0000000      0.0000000      0.0000000       0.000000 #> ICAM3         1.7092120      1.4252724      1.4333825       2.925904 #> FAP           0.0000000      0.0000000      0.0000000       0.000000 #> GZMB          0.9731571      0.2781762      0.6703018       0.000000 #> TSC2          0.2162906      0.2437103      0.2903302       0.000000 #>          X62_Y-85..CD8T X66_Y-85..CD8T X63_Y-85..CD8T X62_Y-82..CD8T #> PDK4            0.00000       0.000000       0.000000              0 #> TNFRSF17        0.00000       0.000000       0.000000              0 #> ICAM3           0.00000       1.386725       4.069315              0 #> FAP             0.00000       0.000000       0.000000              0 #> GZMB            1.05672       0.904150       0.000000              0 #> TSC2            0.00000       0.000000       0.000000              0 #>          X64_Y-82..CD8T X64_Y-83..CD8T X66_Y-84..CD8T X65_Y-85..CD8T #> PDK4           0.000000      0.0000000       0.000000      0.0000000 #> TNFRSF17       0.000000      0.0000000       0.000000      0.0000000 #> ICAM3          1.407061      1.6934696       1.593793      1.8988088 #> FAP            0.000000      0.0000000       0.000000      0.0000000 #> GZMB           0.000000      2.0017363       2.119575      1.0633323 #> TSC2           0.000000      0.8363652       0.000000      0.9290565 #>          X36_Y-92..CD8T X35_Y-93..CD8T X30_Y-94..CD8T X34_Y-96..CD8T #> PDK4           0.000000              0              0              0 #> TNFRSF17       0.000000              0              0              0 #> ICAM3          2.424381              0              0              0 #> FAP            0.000000              0              0              0 #> GZMB           0.000000              0              0              0 #> TSC2           0.000000              0              0              0 #>          X35_Y-92..CD8T X34_Y-93..CD8T X43_Y-85..CD8T X45_Y-86..CD8T #> PDK4           0.000000       0.000000       0.000000      0.0000000 #> TNFRSF17       0.000000       0.000000       0.000000      0.0000000 #> ICAM3          4.848761       6.179867       4.468283      2.8072228 #> FAP            0.000000       0.000000       0.000000      0.0000000 #> GZMB           0.000000       0.000000       0.000000      0.7466574 #> TSC2           0.000000       0.000000       0.000000      0.7466574 #>          X48_Y-86..CD8T X44_Y-86..CD8T X47_Y-86..CD8T X46_Y-86..CD8T #> PDK4           0.000000      0.0000000       0.000000       0.000000 #> TNFRSF17       0.000000      0.0000000       0.000000       0.000000 #> ICAM3          1.513427      0.8592801       1.588771       2.164622 #> FAP            0.000000      0.0000000       0.000000       0.000000 #> GZMB           1.124263      0.8941470       1.188906       1.837662 #> TSC2           0.000000      0.0000000       0.000000       0.000000 #>          X47_Y-87..CD8T X46_Y-87..CD8T X47_Y-88..CD8T X45_Y-88..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.150410       2.602777       1.743714       3.172723 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           1.803082       1.315073       1.018513       1.849195 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X48_Y-88..CD8T X46_Y-88..CD8T X43_Y-89..CD8T X47_Y-89..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.373356       2.576895       4.787888       2.506305 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           1.477229       0.873928       0.000000       0.000000 #> TSC2           0.324947       0.000000       0.000000       0.000000 #>          X46_Y-89..CD8T X48_Y-89..CD8T X45_Y-89..CD8T X47_Y-90..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.357729       2.098185       2.234309       1.964292 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       1.256192       0.000000       0.000000 #> TSC2           0.000000       0.000000       1.363358       0.000000 #>          X46_Y-90..CD8T X43_Y-90..CD8T X45_Y-90..CD8T X47_Y-91..CD8T #> PDK4          0.0000000       0.000000      0.0000000       0.000000 #> TNFRSF17      0.0000000       0.000000      0.0000000       0.000000 #> ICAM3         3.3121447       1.416001      3.4953013       3.491768 #> FAP           0.0000000       0.000000      0.0000000       0.000000 #> GZMB          0.4157211       0.000000      0.5196514       0.000000 #> TSC2          0.0000000       0.000000      0.0000000       0.000000 #>          X46_Y-91..CD8T X45_Y-87..CD8T X44_Y-89..CD8T X44_Y-90..CD8T #> PDK4            0.00000       0.000000       0.000000        0.00000 #> TNFRSF17        0.00000       0.000000       0.000000        0.00000 #> ICAM3           1.89538       2.882369       0.000000        5.95484 #> FAP             0.00000       0.000000       0.000000        0.00000 #> GZMB            0.00000       0.000000       0.000000        0.00000 #> TSC2            0.00000       0.000000       5.453431        0.00000 #>          X51_Y-79..CD8T X49_Y-80..CD8T X50_Y-80..CD8T X51_Y-80..CD8T #> PDK4           0.000000      0.0000000       0.000000      0.0000000 #> TNFRSF17       0.000000      0.0000000       0.000000      0.0000000 #> ICAM3          1.874862      2.1603075       2.106158      2.3850445 #> FAP            0.000000      0.0000000       0.000000      0.0000000 #> GZMB           2.322058      0.4378773       0.000000      0.8644401 #> TSC2           0.000000      0.3498060       0.000000      0.0000000 #>          X53_Y-80..CD8T X52_Y-80..CD8T X52_Y-81..CD8T X50_Y-81..CD8T #> PDK4             0.0000       0.000000       0.000000      0.0000000 #> TNFRSF17         0.0000       0.000000       0.000000      0.0000000 #> ICAM3            1.1691       1.295472       1.295472      1.8358534 #> FAP              0.0000       0.000000       0.000000      0.0000000 #> GZMB             0.0000       1.791804       1.791804      0.3586639 #> TSC2             0.0000       0.000000       0.000000      0.0000000 #>          X53_Y-81..CD8T X51_Y-81..CD8T X50_Y-82..CD8T X52_Y-82..CD8T #> PDK4           0.000000      0.0000000       0.000000       0.000000 #> TNFRSF17       0.000000      0.0000000       0.000000       0.000000 #> ICAM3          2.752725      1.8082843       4.358866       2.873336 #> FAP            0.000000      0.0000000       0.000000       0.000000 #> GZMB           0.000000      0.4843749       0.000000       1.051428 #> TSC2           0.000000      0.0000000       0.000000       0.000000 #>          X53_Y-82..CD8T X51_Y-82..CD8T X49_Y-82..CD8T X51_Y-83..CD8T #> PDK4           0.000000       0.000000       0.000000      0.0000000 #> TNFRSF17       0.000000       0.000000       0.000000      0.0000000 #> ICAM3          3.165961       3.300192       2.822176      1.4759059 #> FAP            0.000000       0.000000       0.000000      0.0000000 #> GZMB           0.000000       1.194726       0.000000      0.5256183 #> TSC2           0.000000       0.000000       0.000000      0.0000000 #>          X52_Y-83..CD8T X53_Y-84..CD8T X54_Y-84..CD8T X49_Y-84..CD8T #> PDK4           0.000000       0.000000      0.0000000       0.000000 #> TNFRSF17       0.000000       0.000000      0.0000000       0.000000 #> ICAM3          3.621239       2.130847      2.7080527       2.090693 #> FAP            0.000000       0.000000      0.0000000       0.000000 #> GZMB           0.000000       2.677175      0.3843472       1.025759 #> TSC2           0.000000       0.000000      0.4151659       0.000000 #>          X52_Y-84..CD8T X51_Y-84..CD8T X52_Y-85..CD8T X50_Y-85..CD8T #> PDK4           0.000000       0.000000      0.0000000       0.000000 #> TNFRSF17       0.000000       0.000000      0.0000000       0.000000 #> ICAM3          4.119759       3.234574      2.6496938       3.219811 #> FAP            0.000000       0.000000      0.0000000       0.000000 #> GZMB           0.000000       0.000000      0.2904758       1.607180 #> TSC2           0.000000       0.000000      0.0000000       0.000000 #>          X53_Y-85..CD8T X51_Y-85..CD8T X49_Y-85..CD8T X49_Y-81..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.955556       2.288920       3.325976       1.255145 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           1.064404       1.021386       1.749434       0.000000 #> TSC2           0.445484       0.000000       0.000000       0.000000 #>          X49_Y-83..CD8T X50_Y-84..CD8T X70_Y-91..CD8T X66_Y-91..CD8T #> PDK4           0.000000       0.000000       0.000000              0 #> TNFRSF17       0.000000       0.000000       0.000000              0 #> ICAM3          4.097200       1.779014       4.410381              0 #> FAP            0.000000       0.000000       0.000000              0 #> GZMB           4.782003       3.376939       4.410381              0 #> TSC2           0.000000       0.000000       0.000000              0 #>          X69_Y-93..CD8T X72_Y-93..CD8T X75_Y-91..CD8T X76_Y-92..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          4.861401       5.658486       5.929589       5.245334 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           4.861401       0.000000       0.000000       5.245334 #> TSC2           0.000000       0.000000       0.000000       5.245334 #>          X78_Y-92..CD8T X73_Y-93..CD8T X78_Y-93..CD8T X77_Y-93..CD8T #> PDK4           0.000000              0       0.000000       0.000000 #> TNFRSF17       0.000000              0       0.000000       0.000000 #> ICAM3          2.084836              0       1.389891       4.635125 #> FAP            0.000000              0       0.000000       0.000000 #> GZMB           0.000000              0       0.000000       5.323408 #> TSC2           0.000000              0       0.000000       0.000000 #>          X75_Y-94..CD8T X77_Y-95..CD8T X74_Y-96..CD8T X76_Y-96..CD8T #> PDK4           0.000000              0       0.000000         0.0000 #> TNFRSF17       0.000000              0       0.000000         0.0000 #> ICAM3          4.754651              0       5.155681         5.9172 #> FAP            0.000000              0       0.000000         0.0000 #> GZMB           0.000000              0       0.000000         0.0000 #> TSC2           0.000000              0       0.000000         0.0000 #>          X77_Y-96..CD8T X47_Y-69..CD8T X45_Y-69..CD8T X47_Y-70..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.443589       2.622667       5.081404       1.141706 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X46_Y-70..CD8T X45_Y-72..CD8T X48_Y-72..CD8T X47_Y-72..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          1.141706       5.057837       2.242739       3.040983 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       3.578498       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X46_Y-68..CD8T X73_Y-64..CD8T X74_Y-65..CD8T X73_Y-65..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.382278       3.242232       2.794589       3.250627 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       1.510126       1.338072       1.476509 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X74_Y-66..CD8T X72_Y-66..CD8T X24_Y-86..CD8T X27_Y-91..CD8T #> PDK4           0.000000       0.000000              0              0 #> TNFRSF17       0.000000       0.000000              0              0 #> ICAM3          2.040059       2.473667              0              0 #> FAP            0.000000       0.000000              0              0 #> GZMB           1.196356       0.000000              0              0 #> TSC2           0.000000       0.000000              0              0 #>          X27_Y-90..CD8T X33_Y-88..CD8T X38_Y-91..CD8T X42_Y-91..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          6.132899       5.408168       5.034617       5.097434 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       4.410381 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X33_Y-100..CD8T X35_Y-100..CD8T X30_Y-102..CD8T X30_Y-103..CD8T #> PDK4            0.000000          0.0000        0.000000        0.000000 #> TNFRSF17        0.000000          0.0000        0.000000        0.000000 #> ICAM3           5.264283          4.9541        3.604498        4.536145 #> FAP             0.000000          0.0000        0.000000        0.000000 #> GZMB            0.000000          0.0000        1.038115        0.000000 #> TSC2            0.000000          0.0000        0.000000        0.000000 #>          X33_Y-103..CD8T X32_Y-103..CD8T X33_Y-104..CD8T X34_Y-100..CD8T #> PDK4           0.0000000               0        0.000000        0.000000 #> TNFRSF17       0.0000000               0        0.000000        0.000000 #> ICAM3          0.9854309               0        4.851533        5.269033 #> FAP            0.0000000               0        0.000000        0.000000 #> GZMB           0.0000000               0        0.000000        0.000000 #> TSC2           0.0000000               0        0.000000        0.000000 #>          X23_Y-104..CD8T X22_Y-103..CD8T X27_Y-98..CD8T X23_Y-99..CD8T #> PDK4            0.000000        0.000000              0       0.000000 #> TNFRSF17        0.000000        0.000000              0       0.000000 #> ICAM3           4.968821        4.848761              0       4.823959 #> FAP             0.000000        0.000000              0       0.000000 #> GZMB            0.000000        0.000000              0       0.000000 #> TSC2            0.000000        0.000000              0       0.000000 #>          X27_Y-101..CD8T X28_Y-101..CD8T X27_Y-102..CD8T X26_Y-103..CD8T #> PDK4                   0         0.00000        0.000000        0.000000 #> TNFRSF17               0         0.00000        0.000000        0.000000 #> ICAM3                  0         2.30756        5.323408        2.762726 #> FAP                    0         0.00000        0.000000        0.000000 #> GZMB                   0         0.00000        4.635125        0.000000 #> TSC2                   0         0.00000        0.000000        0.000000 #>          X77_Y-103..CD8T X77_Y-104..CD8T X78_Y-104..CD8T X73_Y-106..CD8T #> PDK4            0.000000        0.000000        0.000000        0.000000 #> TNFRSF17        0.000000        0.000000        0.000000        0.000000 #> ICAM3           0.000000        0.000000        4.625072        3.427243 #> FAP             0.000000        0.000000        0.000000        0.000000 #> GZMB            2.332959        0.000000        0.000000        0.000000 #> TSC2            2.278723        4.557445        0.000000        0.000000 #>          X76_Y-106..CD8T X63_Y-99..CD8T X61_Y-101..CD8T X64_Y-101..CD8T #> PDK4                   0              0        0.000000        0.000000 #> TNFRSF17               0              0        0.000000        0.000000 #> ICAM3                  0              0        3.530878        5.290126 #> FAP                    0              0        0.000000        0.000000 #> GZMB                   0              0        2.730166        4.201545 #> TSC2                   0              0        0.000000        0.000000 #>          X63_Y-101..CD8T X65_Y-101..CD8T X61_Y-102..CD8T X63_Y-102..CD8T #> PDK4            0.000000               0        0.000000       0.0000000 #> TNFRSF17        0.000000               0        0.000000       0.0000000 #> ICAM3           4.741765               0        2.713145       3.8779095 #> FAP             0.000000               0        0.000000       0.0000000 #> GZMB            0.000000               0        2.145825       0.9171717 #> TSC2            0.000000               0        0.000000       0.0000000 #>          X60_Y-102..CD8T X62_Y-102..CD8T X64_Y-103..CD8T X63_Y-103..CD8T #> PDK4            0.000000        0.000000        0.000000         0.00000 #> TNFRSF17        0.000000        0.000000        0.000000         0.00000 #> ICAM3           2.001511        4.838779        4.305215         1.99888 #> FAP             0.000000        0.000000        0.000000         0.00000 #> GZMB            0.000000        2.317563        0.000000         0.00000 #> TSC2            0.000000        0.000000        0.000000         0.00000 #>          X61_Y-103..CD8T X65_Y-103..CD8T X65_Y-104..CD8T X62_Y-101..CD8T #> PDK4            0.000000        0.000000        0.000000        0.000000 #> TNFRSF17        0.000000        0.000000        0.000000        0.000000 #> ICAM3           2.787588        5.343928        3.560894        5.177008 #> FAP             0.000000        0.000000        0.000000        0.000000 #> GZMB            1.588185        0.000000        1.147275        1.506933 #> TSC2            0.000000        0.000000        0.000000        0.000000 #>          X64_Y-102..CD8T X62_Y-103..CD8T X23_Y-105..CD8T X23_Y-106..CD8T #> PDK4                   0        0.000000        0.000000               0 #> TNFRSF17               0        0.000000        0.000000               0 #> ICAM3                  0        4.510081        1.595963               0 #> FAP                    0        0.000000        0.000000               0 #> GZMB                   0        1.158781        0.000000               0 #> TSC2                   0        0.000000        0.000000               0 #>          X22_Y-107..CD8T X69_Y-85..CD8T X66_Y-86..CD8T X69_Y-86..CD8T #> PDK4            0.000000       0.000000       0.000000       0.000000 #> TNFRSF17        0.000000       0.000000       0.000000       0.000000 #> ICAM3           5.658486       4.990139       1.920446       4.787888 #> FAP             0.000000       0.000000       0.000000       0.000000 #> GZMB            0.000000       0.000000       0.000000       0.000000 #> TSC2            0.000000       0.000000       0.000000       0.000000 #>          X67_Y-86..CD8T X68_Y-87..CD8T X72_Y-87..CD8T X67_Y-87..CD8T #> PDK4           0.000000       0.000000              0       0.000000 #> TNFRSF17       0.000000       0.000000              0       0.000000 #> ICAM3          4.525400       5.791852              0       4.724259 #> FAP            0.000000       0.000000              0       0.000000 #> GZMB           0.000000       0.000000              0       0.000000 #> TSC2           2.269476       0.000000              0       1.512984 #>          X69_Y-88..CD8T X71_Y-88..CD8T X72_Y-90..CD8T X70_Y-90..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          5.089419       5.747799       1.961036       5.974209 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           2.197225       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X73_Y-91..CD8T X68_Y-86..CD8T X72_Y-86..CD8T X67_Y-89..CD8T #> PDK4                  0       0.000000              0       0.000000 #> TNFRSF17              0       0.000000              0       0.000000 #> ICAM3                 0       5.272503              0       1.696462 #> FAP                   0       0.000000              0       0.000000 #> GZMB                  0       0.000000              0       1.696462 #> TSC2                  0       0.000000              0       0.000000 #>          X28_Y-104..CD8T X25_Y-105..CD8T X24_Y-105..CD8T X24_Y-106..CD8T #> PDK4            0.000000        0.000000               0        0.000000 #> TNFRSF17        0.000000        0.000000               0        0.000000 #> ICAM3           5.050104        2.952722               0        2.359745 #> FAP             0.000000        0.000000               0        0.000000 #> GZMB            0.000000        0.000000               0        0.000000 #> TSC2            0.000000        0.000000               0        2.359745 #>          X25_Y-106..CD8T X26_Y-106..CD8T X26_Y-107..CD8T X28_Y-107..CD8T #> PDK4            0.000000         0.00000         0.00000               0 #> TNFRSF17        0.000000         0.00000         0.00000               0 #> ICAM3           5.361098         2.46331         2.46331               0 #> FAP             0.000000         0.00000         0.00000               0 #> GZMB            0.000000         0.00000         0.00000               0 #> TSC2            0.000000         0.00000         0.00000               0 #>          X73_Y-98..CD8T X68_Y-102..CD8T X68_Y-104..CD8T X66_Y-104..CD8T #> PDK4           0.000000               0        0.000000        0.000000 #> TNFRSF17       0.000000               0        0.000000        0.000000 #> ICAM3          4.874205               0        4.635125        5.190573 #> FAP            0.000000               0        0.000000        0.000000 #> GZMB           0.000000               0        5.323408        0.000000 #> TSC2           0.000000               0        0.000000        0.000000 #>          X70_Y-105..CD8T X71_Y-105..CD8T X67_Y-105..CD8T X68_Y-106..CD8T #> PDK4            0.000000       0.0000000        0.000000        0.000000 #> TNFRSF17        0.000000       0.0000000        0.000000        0.000000 #> ICAM3           4.587305       2.7324445        2.595287        0.000000 #> FAP             0.000000       0.0000000        0.000000        0.000000 #> GZMB            0.000000       0.0000000        0.000000        2.338201 #> TSC2            0.000000       0.8988378        0.000000        0.000000 #>          X71_Y-106..CD8T X70_Y-104..CD8T X68_Y-105..CD8T X70_Y-106..CD8T #> PDK4            0.000000        0.000000               0        0.000000 #> TNFRSF17        0.000000        0.000000               0        0.000000 #> ICAM3           4.351536        4.624126               0        4.913648 #> FAP             0.000000        0.000000               0        0.000000 #> GZMB            2.025715        0.000000               0        0.000000 #> TSC2            0.000000        0.000000               0        0.000000 #>          X57_Y-104..CD8T X55_Y-104..CD8T X59_Y-104..CD8T X58_Y-104..CD8T #> PDK4            0.000000        0.000000        0.000000        0.000000 #> TNFRSF17        0.000000        0.000000        0.000000        0.000000 #> ICAM3           1.087039        3.424788        2.436279        2.042729 #> FAP             0.000000        0.000000        0.000000        0.000000 #> GZMB            1.316071        0.000000        1.269158        3.676378 #> TSC2            0.000000        1.132458        0.000000        0.000000 #>          X54_Y-104..CD8T X59_Y-105..CD8T X60_Y-105..CD8T X57_Y-105..CD8T #> PDK4            0.000000        0.000000        0.000000        0.000000 #> TNFRSF17        0.000000        0.000000        0.000000        0.000000 #> ICAM3           5.014032        2.323662        5.747799        2.210220 #> FAP             0.000000        0.000000        0.000000        0.000000 #> GZMB            1.151317        1.330505        0.000000        1.773897 #> TSC2            1.132458        0.000000        0.000000        0.000000 #>          X58_Y-105..CD8T X55_Y-106..CD8T X54_Y-106..CD8T X59_Y-106..CD8T #> PDK4           0.0000000       0.0000000       0.0000000        0.000000 #> TNFRSF17       0.0000000       0.0000000       0.0000000        0.000000 #> ICAM3          1.3215920       0.7810725       1.2681636        2.083457 #> FAP            0.0000000       0.0000000       0.0000000        0.000000 #> GZMB           2.1308523       0.8526187       0.5913206        2.958706 #> TSC2           0.6726485       0.3837724       0.0000000        0.000000 #>          X56_Y-106..CD8T X57_Y-106..CD8T X54_Y-107..CD8T X55_Y-107..CD8T #> PDK4           0.0000000        0.000000       0.0000000       0.0000000 #> TNFRSF17       0.0000000        0.000000       0.0000000       0.0000000 #> ICAM3          1.6154075        3.131085       2.7144880       2.7651569 #> FAP            0.0000000        0.000000       0.0000000       0.0000000 #> GZMB           0.5628478        1.717709       0.6458286       0.4739053 #> TSC2           0.9965127        0.000000       0.0000000       0.0000000 #>          X56_Y-104..CD8T X55_Y-105..CD8T X56_Y-105..CD8T X58_Y-106..CD8T #> PDK4            0.000000         0.00000               0        0.000000 #> TNFRSF17        0.000000         0.00000               0        0.000000 #> ICAM3           2.006819         1.52862               0        2.934565 #> FAP             0.000000         0.00000               0        0.000000 #> GZMB            0.000000         0.00000               0        4.897960 #> TSC2            0.000000         0.00000               0        0.000000 #>          X56_Y-107..CD8T X57_Y-107..CD8T X64_Y-104..CD8T X61_Y-104..CD8T #> PDK4           0.0000000        0.000000        0.000000        0.000000 #> TNFRSF17       0.0000000        0.000000        0.000000        0.000000 #> ICAM3          3.3984732        0.000000        3.839446        4.676402 #> FAP            0.0000000        0.000000        0.000000        0.000000 #> GZMB           1.5551297        5.612132        0.996622        4.676402 #> TSC2           0.7272242        0.000000        0.000000        0.000000 #>          X65_Y-105..CD8T X62_Y-105..CD8T X64_Y-105..CD8T X62_Y-106..CD8T #> PDK4            0.000000        0.000000               0        0.000000 #> TNFRSF17        0.000000        0.000000               0        0.000000 #> ICAM3           1.906253        1.687675               0        2.281482 #> FAP             0.000000        0.000000               0        0.000000 #> GZMB            1.835639        2.013298               0        4.096881 #> TSC2            0.000000        0.000000               0        0.000000 #>          X61_Y-106..CD8T X64_Y-106..CD8T X63_Y-106..CD8T X66_Y-107..CD8T #> PDK4            0.000000               0        0.000000         0.00000 #> TNFRSF17        0.000000               0        0.000000         0.00000 #> ICAM3           1.459591               0        0.000000         2.11391 #> FAP             0.000000               0        0.000000         0.00000 #> GZMB            2.800854               0        1.730191         0.00000 #> TSC2            0.000000               0        0.000000         0.00000 #>          X67_Y-107..CD8T X63_Y-104..CD8T X61_Y-107..CD8T X64_Y-107..CD8T #> PDK4             0.00000        0.000000        0.000000        0.000000 #> TNFRSF17         0.00000        0.000000        0.000000        0.000000 #> ICAM3            4.22782        3.346982        2.201191        3.879363 #> FAP              0.00000        0.000000        0.000000        0.000000 #> GZMB             0.00000        1.661037        1.967140        0.000000 #> TSC2             0.00000        0.000000        0.000000        0.000000 #>          X49_Y-103..CD8T X49_Y-104..CD8T X48_Y-104..CD8T X52_Y-105..CD8T #> PDK4            0.000000        0.000000        0.000000        0.000000 #> TNFRSF17        0.000000        0.000000        0.000000        0.000000 #> ICAM3           1.486600        0.000000        0.000000        2.760200 #> FAP             0.000000        0.000000        0.000000        0.000000 #> GZMB            1.715716        0.000000        0.000000        1.226856 #> TSC2            0.000000        1.284671        2.569343        0.000000 #>          X53_Y-105..CD8T X54_Y-105..CD8T X51_Y-106..CD8T X48_Y-107..CD8T #> PDK4           0.0000000       0.0000000       0.0000000        0.000000 #> TNFRSF17       0.0000000       0.0000000       0.0000000        0.000000 #> ICAM3          0.6248929       3.3482422       0.9827296        2.459723 #> FAP            0.0000000       0.0000000       0.0000000        0.000000 #> GZMB           0.7125970       1.9526771       1.6383472        2.549121 #> TSC2           0.0000000       0.6471191       0.0000000        0.000000 #>          X53_Y-107..CD8T X50_Y-107..CD8T X50_Y-103..CD8T X51_Y-104..CD8T #> PDK4            0.000000        0.000000        0.000000        0.000000 #> TNFRSF17        0.000000        0.000000        0.000000        0.000000 #> ICAM3           1.580588        2.582144        1.634674        1.225109 #> FAP             0.000000        0.000000        0.000000        0.000000 #> GZMB            1.489428        4.675524        3.052975        2.844962 #> TSC2            0.000000        0.000000        0.000000        0.000000 #>          X52_Y-106..CD8T X31_Y-104..CD8T X30_Y-107..CD8T X31_Y-103..CD8T #> PDK4             0.00000        0.000000          0.0000               0 #> TNFRSF17         0.00000        0.000000          0.0000               0 #> ICAM3            4.18867        1.110762          4.0462               0 #> FAP              0.00000        0.000000          0.0000               0 #> GZMB             0.00000        0.000000          0.0000               0 #> TSC2             0.00000        0.000000          0.0000               0 #>          X42_Y-103..CD8T X43_Y-105..CD8T X42_Y-106..CD8T X46_Y-106..CD8T #> PDK4            0.000000        0.000000       0.0000000        0.000000 #> TNFRSF17        0.000000        0.000000       0.0000000        0.000000 #> ICAM3           1.964449        1.852899       1.9916756        3.603166 #> FAP             0.000000        0.000000       0.0000000        0.000000 #> GZMB            0.000000        4.688457       0.0000000        0.000000 #> TSC2            0.000000        0.000000       0.9245222        0.000000 #>          X44_Y-106..CD8T X43_Y-107..CD8T X42_Y-107..CD8T X45_Y-107..CD8T #> PDK4            0.000000        0.000000        0.000000        0.000000 #> TNFRSF17        0.000000        0.000000        0.000000        0.000000 #> ICAM3           2.391002        0.000000        2.705202        4.351933 #> FAP             0.000000        0.000000        0.000000        0.000000 #> GZMB            2.418141        4.836282        1.308979        0.000000 #> TSC2            0.000000        0.000000        0.000000        0.000000 #>          X47_Y-107..CD8T X47_Y-105..CD8T X56_Y-98..CD8T X59_Y-98..CD8T #> PDK4            0.000000               0      0.0000000       0.000000 #> TNFRSF17        0.000000               0      0.0000000       0.000000 #> ICAM3           2.283413               0      3.1912723       1.422871 #> FAP             0.000000               0      0.0000000       0.000000 #> GZMB            2.283413               0      1.9189710       0.000000 #> TSC2            0.000000               0      0.4727583       0.000000 #>          X57_Y-98..CD8T X59_Y-99..CD8T X55_Y-99..CD8T X56_Y-99..CD8T #> PDK4           0.000000       0.000000      0.0000000      0.0000000 #> TNFRSF17       0.000000       0.000000      0.0000000      0.0000000 #> ICAM3          2.578708       4.268613      2.3586976      4.0403501 #> FAP            0.000000       0.000000      0.0000000      0.0000000 #> GZMB           1.387668       0.000000      0.5303305      2.3887799 #> TSC2           0.000000       0.000000      0.0000000      0.7091374 #>          X54_Y-100..CD8T X60_Y-100..CD8T X60_Y-101..CD8T X56_Y-101..CD8T #> PDK4            0.000000               0        0.000000        0.000000 #> TNFRSF17        0.000000               0        0.000000        0.000000 #> ICAM3           1.759156               0        1.995124        5.430541 #> FAP             0.000000               0        0.000000        0.000000 #> GZMB            1.269596               0        1.993058        4.340652 #> TSC2            0.000000               0        0.000000        0.000000 #>          X58_Y-102..CD8T X57_Y-102..CD8T X59_Y-103..CD8T X57_Y-103..CD8T #> PDK4            0.000000        0.000000        0.000000        0.000000 #> TNFRSF17        0.000000        0.000000        0.000000        0.000000 #> ICAM3           4.950236        4.621207        2.528918        3.951636 #> FAP             0.000000        0.000000        0.000000        0.000000 #> GZMB            0.000000        0.000000        0.000000        0.000000 #> TSC2            0.000000        0.000000        0.000000        0.000000 #>          X54_Y-98..CD8T X54_Y-99..CD8T X57_Y-100..CD8T X55_Y-100..CD8T #> PDK4           0.000000       0.000000         0.00000       0.0000000 #> TNFRSF17       0.000000       0.000000         0.00000       0.0000000 #> ICAM3          4.626574       2.423956         5.50899       2.0525876 #> FAP            0.000000       0.000000         0.00000       0.0000000 #> GZMB           1.603929       0.000000         0.00000       0.6458286 #> TSC2           0.000000       0.000000         0.00000       0.0000000 #>          X38_Y-100..CD8T X41_Y-101..CD8T X42_Y-102..CD8T X41_Y-102..CD8T #> PDK4                   0        0.000000        0.000000        0.000000 #> TNFRSF17               0        0.000000        0.000000        0.000000 #> ICAM3                  0        2.599929        3.584065        3.484495 #> FAP                    0        0.000000        0.000000        0.000000 #> GZMB                   0        1.276387        0.000000        0.000000 #> TSC2                   0        0.000000        0.000000        0.000000 #>          X41_Y-103..CD8T X61_Y-85..CD8T X63_Y-86..CD8T X62_Y-86..CD8T #> PDK4            0.000000       0.000000       0.000000      0.0000000 #> TNFRSF17        0.000000       0.000000       0.000000      0.0000000 #> ICAM3           1.754761       2.350389       4.692095      1.5087497 #> FAP             0.000000       0.000000       0.000000      0.0000000 #> GZMB            0.000000       0.000000       0.000000      0.9957014 #> TSC2            0.000000       0.000000       0.000000      0.0000000 #>          X61_Y-86..CD8T X65_Y-86..CD8T X61_Y-87..CD8T X60_Y-87..CD8T #> PDK4          0.0000000       0.000000       0.000000       0.000000 #> TNFRSF17      0.0000000       0.000000       0.000000       0.000000 #> ICAM3         2.7134637       4.840886       2.498489       1.230095 #> FAP           0.0000000       0.000000       0.000000       0.000000 #> GZMB          0.9895535       0.000000       1.904691       1.104611 #> TSC2          0.0000000       0.000000       0.000000       0.000000 #>          X62_Y-87..CD8T X63_Y-87..CD8T X62_Y-88..CD8T X62_Y-89..CD8T #> PDK4          0.0000000       0.000000       0.000000       0.000000 #> TNFRSF17      0.0000000       0.000000       0.000000       0.000000 #> ICAM3         1.8478400       4.635125       1.096645       2.187626 #> FAP           0.0000000       0.000000       0.000000       0.000000 #> GZMB          1.1407125       0.000000       0.000000       0.880152 #> TSC2          0.5606847       0.000000       1.121369       0.000000 #>          X64_Y-89..CD8T X66_Y-89..CD8T X61_Y-89..CD8T X63_Y-89..CD8T #> PDK4           0.000000              0       0.000000      0.0000000 #> TNFRSF17       0.000000              0       0.000000      0.0000000 #> ICAM3          2.411979              0       1.786822      3.9560522 #> FAP            0.000000              0       0.000000      0.0000000 #> GZMB           0.000000              0       2.163472      0.7365258 #> TSC2           0.000000              0       0.000000      0.0000000 #>          X62_Y-90..CD8T X61_Y-90..CD8T X64_Y-90..CD8T X63_Y-90..CD8T #> PDK4           0.000000      0.0000000       0.000000       0.000000 #> TNFRSF17       0.000000      0.0000000       0.000000       0.000000 #> ICAM3          3.011852      4.4174895       2.651652       4.743470 #> FAP            0.000000      0.0000000       0.000000       0.000000 #> GZMB           2.156485      0.3951471       0.000000       1.031136 #> TSC2           0.000000      0.0000000       2.651652       0.000000 #>          X65_Y-90..CD8T X60_Y-91..CD8T X64_Y-86..CD8T X63_Y-91..CD8T #> PDK4                  0      0.0000000       0.000000       0.000000 #> TNFRSF17              0      0.0000000       0.000000       0.000000 #> ICAM3                 0      1.1484035       4.625072       1.531839 #> FAP                   0      0.0000000       0.000000       0.000000 #> GZMB                  0      0.6228888       0.000000       3.029600 #> TSC2                  0      0.0000000       0.000000       0.000000 #>          X36_Y-93..CD8T X38_Y-94..CD8T X40_Y-94..CD8T X39_Y-96..CD8T #> PDK4                  0       0.000000       0.000000       0.000000 #> TNFRSF17              0       0.000000       0.000000       0.000000 #> ICAM3                 0       2.137791       4.214594       4.571217 #> FAP                   0       0.000000       0.000000       0.000000 #> GZMB                  0       2.544693       0.000000       0.000000 #> TSC2                  0       0.000000       0.000000       0.000000 #>          X41_Y-97..CD8T X40_Y-93..CD8T X39_Y-95..CD8T X42_Y-96..CD8T #> PDK4           0.000000       0.000000              0              0 #> TNFRSF17       0.000000       0.000000              0              0 #> ICAM3          5.935842       4.874205              0              0 #> FAP            0.000000       0.000000              0              0 #> GZMB           0.000000       4.188670              0              0 #> TSC2           0.000000       0.000000              0              0 #>          X41_Y-96..CD8T X41_Y-104..CD8T X40_Y-105..CD8T X41_Y-106..CD8T #> PDK4           0.000000        0.000000        0.000000       0.0000000 #> TNFRSF17       0.000000        0.000000        0.000000       0.0000000 #> ICAM3          3.756486        4.874205        4.954735       2.3228422 #> FAP            0.000000        0.000000        0.000000       0.0000000 #> GZMB           0.000000        0.000000        2.477368       0.7595742 #> TSC2           0.000000        0.000000        0.000000       0.0000000 #>          X40_Y-106..CD8T X41_Y-107..CD8T X41_Y-105..CD8T X40_Y-107..CD8T #> PDK4            0.000000       0.0000000        0.000000        0.000000 #> TNFRSF17        0.000000       0.0000000        0.000000        0.000000 #> ICAM3           1.277749       2.5353918        3.170727        3.350614 #> FAP             0.000000       0.0000000        0.000000        0.000000 #> GZMB            0.000000       0.6544894        3.175422        0.000000 #> TSC2            0.000000       0.8509247        0.000000        0.000000 #>          X53_Y-86..CD8T X50_Y-86..CD8T X54_Y-86..CD8T X51_Y-86..CD8T #> PDK4          0.0000000      0.0000000       0.000000      0.0000000 #> TNFRSF17      0.0000000      0.0000000       0.000000      0.0000000 #> ICAM3         2.5466688      1.9946733       3.305990      3.2606664 #> FAP           0.0000000      0.0000000       0.000000      0.0000000 #> GZMB          0.8156533      0.5023111       1.736874      0.5696807 #> TSC2          0.0000000      0.0000000       0.000000      0.0000000 #>          X49_Y-86..CD8T X52_Y-86..CD8T X54_Y-87..CD8T X52_Y-87..CD8T #> PDK4           0.000000       0.000000      0.0000000       0.000000 #> TNFRSF17       0.000000       0.000000      0.0000000       0.000000 #> ICAM3          1.116313       2.357539      2.4793185       2.454733 #> FAP            0.000000       0.000000      0.0000000       0.000000 #> GZMB           2.732567       0.000000      0.8665649       1.149263 #> TSC2           0.000000       0.000000      0.0000000       0.000000 #>          X53_Y-87..CD8T X51_Y-87..CD8T X50_Y-87..CD8T X55_Y-87..CD8T #> PDK4           0.000000      0.0000000       0.000000      0.0000000 #> TNFRSF17       0.000000      0.0000000       0.000000      0.0000000 #> ICAM3          3.732583      1.5635845       3.157049      2.0320291 #> FAP            0.000000      0.0000000       0.000000      0.0000000 #> GZMB           0.000000      0.3303623       0.000000      0.9895394 #> TSC2           0.000000      0.0000000       0.000000      0.0000000 #>          X51_Y-88..CD8T X49_Y-88..CD8T X52_Y-88..CD8T X50_Y-88..CD8T #> PDK4           0.000000      0.0000000      0.0000000      0.0000000 #> TNFRSF17       0.000000      0.0000000      0.0000000      0.0000000 #> ICAM3          1.964094      1.5206385      3.1038628      2.5882922 #> FAP            0.000000      0.0000000      0.0000000      0.0000000 #> GZMB           0.000000      0.0000000      0.8332802      0.5672831 #> TSC2           0.000000      0.4061838      0.0000000      0.4165953 #>          X53_Y-88..CD8T X54_Y-88..CD8T X51_Y-89..CD8T X50_Y-89..CD8T #> PDK4           0.000000      0.0000000      0.0000000      0.0000000 #> TNFRSF17       0.000000      0.0000000      0.0000000      0.0000000 #> ICAM3          2.831499      3.3646137      1.7699481      2.4294955 #> FAP            0.000000      0.0000000      0.0000000      0.0000000 #> GZMB           0.000000      0.7559861      0.8939245      1.4348636 #> TSC2           0.000000      0.0000000      0.0000000      0.7829516 #>          X53_Y-89..CD8T X49_Y-89..CD8T X54_Y-89..CD8T X52_Y-89..CD8T #> PDK4           0.000000       0.000000      0.0000000      0.0000000 #> TNFRSF17       0.000000       0.000000      0.0000000      0.0000000 #> ICAM3          2.490898       2.954208      2.3777906      2.6157568 #> FAP            0.000000       0.000000      0.0000000      0.0000000 #> GZMB           0.000000       1.220016      0.5463786      0.9932495 #> TSC2           0.000000       0.000000      0.0000000      0.0000000 #>          X51_Y-90..CD8T X52_Y-90..CD8T X50_Y-90..CD8T X54_Y-90..CD8T #> PDK4          0.0000000       0.000000      0.0000000      0.0000000 #> TNFRSF17      0.0000000       0.000000      0.0000000      0.0000000 #> ICAM3         1.6801167       2.276192      3.3041317      1.9021014 #> FAP           0.0000000       0.000000      0.0000000      0.0000000 #> GZMB          0.8836891       1.417228      0.0000000      0.7853872 #> TSC2          0.0000000       0.000000      0.7829516      0.0000000 #>          X49_Y-90..CD8T X48_Y-90..CD8T X51_Y-91..CD8T X54_Y-91..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          3.752339       3.691567       4.555484       1.629059 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       2.775001       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X49_Y-87..CD8T X52_Y-91..CD8T X55_Y-86..CD8T X58_Y-86..CD8T #> PDK4           0.000000              0      0.0000000       0.000000 #> TNFRSF17       0.000000              0      0.0000000       0.000000 #> ICAM3          2.054943              0      2.2399314       2.370629 #> FAP            0.000000              0      0.0000000       0.000000 #> GZMB           0.000000              0      0.4855622       1.079017 #> TSC2           0.000000              0      0.2019423       0.258369 #>          X56_Y-86..CD8T X59_Y-86..CD8T X57_Y-86..CD8T X60_Y-86..CD8T #> PDK4          0.0000000       0.000000      0.0000000       0.000000 #> TNFRSF17      0.0000000       0.000000      0.0000000       0.000000 #> ICAM3         1.9868697       1.414461      1.8989400       4.695632 #> FAP           0.0000000       0.000000      0.0000000       0.000000 #> GZMB          0.0000000       1.569088      0.7079074       1.346899 #> TSC2          0.9513777       0.000000      0.2540314       0.000000 #>          X57_Y-87..CD8T X58_Y-87..CD8T X59_Y-87..CD8T X56_Y-87..CD8T #> PDK4          0.0000000      0.0000000      0.0000000      0.0000000 #> TNFRSF17      0.0000000      0.0000000      0.0000000      0.0000000 #> ICAM3         2.5933144      3.0410020      3.1316414      0.6578956 #> FAP           0.0000000      0.0000000      0.0000000      0.0000000 #> GZMB          0.0000000      0.3542515      0.9933893      0.6742129 #> TSC2          0.3255318      0.3505727      0.0000000      1.9040665 #>          X58_Y-88..CD8T X57_Y-88..CD8T X59_Y-88..CD8T X55_Y-88..CD8T #> PDK4           0.000000      0.0000000       0.000000      0.0000000 #> TNFRSF17       0.000000      0.0000000       0.000000      0.0000000 #> ICAM3          1.724694      2.1929030       2.319389      2.7985833 #> FAP            0.000000      0.0000000       0.000000      0.0000000 #> GZMB           0.667991      0.3817091       2.824297      0.4943154 #> TSC2           0.000000      0.2735443       0.000000      0.2531745 #>          X56_Y-88..CD8T X55_Y-89..CD8T X59_Y-89..CD8T X58_Y-89..CD8T #> PDK4           0.000000      0.0000000       0.000000       0.000000 #> TNFRSF17       0.000000      0.0000000       0.000000       0.000000 #> ICAM3          1.894707      2.5732807       2.061679       2.911906 #> FAP            0.000000      0.0000000       0.000000       0.000000 #> GZMB           1.038720      0.5702217       3.017911       3.968168 #> TSC2           0.000000      0.2869311       0.000000       0.000000 #>          X56_Y-89..CD8T X57_Y-89..CD8T X60_Y-89..CD8T X59_Y-90..CD8T #> PDK4          0.0000000       0.000000      0.0000000      0.0000000 #> TNFRSF17      0.0000000       0.000000      0.0000000      0.0000000 #> ICAM3         3.2368737       1.754483      1.3542150      1.1884005 #> FAP           0.0000000       0.000000      0.0000000      0.0000000 #> GZMB          0.5227870       1.908738      0.6524036      0.8380497 #> TSC2          0.6176061       0.000000      0.0000000      0.3951471 #>          X56_Y-90..CD8T X60_Y-90..CD8T X58_Y-90..CD8T X57_Y-90..CD8T #> PDK4           0.000000      0.0000000      0.0000000       0.000000 #> TNFRSF17       0.000000      0.0000000      0.0000000       0.000000 #> ICAM3          3.591725      1.1412379      2.7274601       2.361668 #> FAP            0.000000      0.0000000      0.0000000       0.000000 #> GZMB           1.836751      0.4152592      2.2952125       0.555290 #> TSC2           0.449168      0.0000000      0.6847378       0.000000 #>          X55_Y-90..CD8T X56_Y-91..CD8T X57_Y-64..CD8T X55_Y-65..CD8T #> PDK4          0.0000000       0.000000        0.00000      0.0000000 #> TNFRSF17      0.0000000       0.000000        0.00000      0.0000000 #> ICAM3         2.3622212       4.862580        4.80661      2.3031323 #> FAP           0.0000000       0.000000        0.00000      0.0000000 #> GZMB          0.7708453       2.684107        0.00000      0.5714436 #> TSC2          0.6689396       0.000000        0.00000      0.0000000 #>          X57_Y-65..CD8T X56_Y-65..CD8T X59_Y-65..CD8T X58_Y-65..CD8T #> PDK4           0.000000       0.000000              0       0.000000 #> TNFRSF17       0.000000       0.000000              0       0.000000 #> ICAM3          2.377696       2.173268              0       3.672643 #> FAP            0.000000       0.000000              0       0.000000 #> GZMB           3.883683       1.268206              0       0.000000 #> TSC2           0.000000       0.000000              0       0.000000 #>          X55_Y-66..CD8T X55_Y-64..CD8T X56_Y-66..CD8T X59_Y-66..CD8T #> PDK4          0.0000000      0.0000000       0.000000       0.000000 #> TNFRSF17      0.0000000      0.0000000       0.000000       0.000000 #> ICAM3         4.0281344      1.9375535       2.162236       1.464816 #> FAP           0.0000000      0.0000000       0.000000       0.000000 #> GZMB          0.7098315      0.4571549       2.015823       3.383820 #> TSC2          0.0000000      0.0000000       0.000000       0.000000 #>          X72_Y-64..CD8T X72_Y-65..CD8T X70_Y-65..CD8T X71_Y-65..CD8T #> PDK4                  0        0.00000       0.000000      0.0000000 #> TNFRSF17              0        0.00000       0.000000      0.0000000 #> ICAM3                 0        2.52211       0.000000      0.9051745 #> FAP                   0        0.00000       0.000000      0.0000000 #> GZMB                  0        0.00000       2.242739      1.1213694 #> TSC2                  0        0.00000       0.000000      0.0000000 #>          X67_Y-65..CD8T X67_Y-66..CD8T X73_Y-67..CD8T X71_Y-64..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          4.416562       1.641226       4.606438       0.000000 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       2.293403       1.495159 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X49_Y-97..CD8T X54_Y-97..CD8T X48_Y-98..CD8T X50_Y-98..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          0.000000       4.036189       0.000000       3.458783 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           2.153787       1.822900       5.089387       0.845326 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X48_Y-99..CD8T X50_Y-99..CD8T X51_Y-99..CD8T X49_Y-99..CD8T #> PDK4            0.00000       0.000000      0.0000000       0.000000 #> TNFRSF17        0.00000       0.000000      0.0000000       0.000000 #> ICAM3           3.35045       2.334399      2.9710057       3.458041 #> FAP             0.00000       0.000000      0.0000000       0.000000 #> GZMB            2.18397       2.279784      0.8159799       0.999553 #> TSC2            0.00000       0.568193      0.0000000       0.000000 #>          X53_Y-99..CD8T X50_Y-100..CD8T X52_Y-99..CD8T X51_Y-100..CD8T #> PDK4           0.000000       0.0000000       0.000000        0.000000 #> TNFRSF17       0.000000       0.0000000       0.000000        0.000000 #> ICAM3          3.231300       2.3632561       2.514855        3.125649 #> FAP            0.000000       0.0000000       0.000000        0.000000 #> GZMB           1.754761       3.3582018       2.418666        2.592712 #> TSC2           0.000000       0.2622429       0.000000        0.000000 #>          X49_Y-100..CD8T X53_Y-100..CD8T X48_Y-100..CD8T X51_Y-101..CD8T #> PDK4           0.0000000        0.000000       0.0000000        0.000000 #> TNFRSF17       0.0000000        0.000000       0.0000000        0.000000 #> ICAM3          3.4534618        1.565903       3.4045804        3.318310 #> FAP            0.0000000        0.000000       0.0000000        0.000000 #> GZMB           2.2096792        0.000000       0.0000000        3.487846 #> TSC2           0.7641125        0.000000       0.3539444        0.000000 #>          X49_Y-101..CD8T X48_Y-101..CD8T X50_Y-101..CD8T X54_Y-101..CD8T #> PDK4           0.0000000       0.0000000        0.000000        0.000000 #> TNFRSF17       0.0000000       0.0000000        0.000000        0.000000 #> ICAM3          1.4462725       2.3958996        1.295388        1.565903 #> FAP            0.0000000       0.0000000        0.000000        0.000000 #> GZMB           1.2231037       0.6176543        3.514943        1.878655 #> TSC2           0.3310743       0.0000000        0.000000        0.000000 #>          X52_Y-101..CD8T X49_Y-102..CD8T X50_Y-102..CD8T X53_Y-102..CD8T #> PDK4            0.000000       0.0000000        0.000000        0.000000 #> TNFRSF17        0.000000       0.0000000        0.000000        0.000000 #> ICAM3           3.426183       1.9967346        1.749537        2.437103 #> FAP             0.000000       0.0000000        0.000000        0.000000 #> GZMB            2.198423       1.4517498        1.984117        2.255925 #> TSC2            1.008806       0.3912697        0.000000        0.000000 #>          X52_Y-102..CD8T X52_Y-103..CD8T X50_Y-104..CD8T X49_Y-98..CD8T #> PDK4            0.000000        0.000000         0.00000        0.00000 #> TNFRSF17        0.000000        0.000000         0.00000        0.00000 #> ICAM3           2.412590        2.388077         2.11287        2.30756 #> FAP             0.000000        0.000000         0.00000        0.00000 #> GZMB            2.480004        2.704084         3.32776        2.30756 #> TSC2            0.000000        0.000000         0.00000        0.00000 #>          X53_Y-101..CD8T X48_Y-102..CD8T X48_Y-103..CD8T X46_Y-98..CD8T #> PDK4            0.000000       0.0000000        0.000000        0.00000 #> TNFRSF17        0.000000       0.0000000        0.000000        0.00000 #> ICAM3           2.348855       1.3239700        3.394891        1.74903 #> FAP             0.000000       0.0000000        0.000000        0.00000 #> GZMB            0.000000       2.0938069        0.000000        4.04196 #> TSC2            0.000000       0.4303966        0.000000        0.00000 #>          X47_Y-98..CD8T X43_Y-98..CD8T X42_Y-98..CD8T X46_Y-99..CD8T #> PDK4           0.000000              0              0              0 #> TNFRSF17       0.000000              0              0              0 #> ICAM3          5.880932              0              0              0 #> FAP            0.000000              0              0              0 #> GZMB           0.000000              0              0              0 #> TSC2           0.000000              0              0              0 #>          X44_Y-99..CD8T X43_Y-100..CD8T X45_Y-100..CD8T X43_Y-101..CD8T #> PDK4           0.000000        0.000000               0        0.000000 #> TNFRSF17       0.000000        0.000000               0        0.000000 #> ICAM3          0.000000        2.661704               0        0.000000 #> FAP            0.000000        0.000000               0        0.000000 #> GZMB           3.761591        2.327773               0        4.655546 #> TSC2           0.000000        0.000000               0        0.000000 #>          X47_Y-101..CD8T X42_Y-101..CD8T X43_Y-103..CD8T X45_Y-98..CD8T #> PDK4           0.0000000        0.000000               0       0.000000 #> TNFRSF17       0.0000000        0.000000               0       0.000000 #> ICAM3          1.5852851        0.000000               0       0.000000 #> FAP            0.0000000        0.000000               0       0.000000 #> GZMB           0.6964222        2.552774               0       2.292929 #> TSC2           0.0000000        0.000000               0       0.000000 #>          X47_Y-100..CD8T X46_Y-101..CD8T X47_Y-103..CD8T X27_Y-91..DC #> PDK4           0.0000000          0.0000        0.000000     4.615121 #> TNFRSF17       0.0000000          0.0000        0.000000     0.000000 #> ICAM3          2.2683142          2.9586        2.255925     3.931826 #> FAP            0.0000000          0.0000        0.000000     0.000000 #> GZMB           0.8091768          3.1339        0.000000     0.000000 #> TSC2           0.0000000          0.0000        0.000000     3.931826 #>          X24_Y-92..DC X27_Y-95..DC X24_Y-96..DC X26_Y-96..DC X26_Y-97..DC #> PDK4                0     4.088511     2.967728     2.681653     2.436754 #> TNFRSF17            0     0.000000     0.000000     0.000000     0.000000 #> ICAM3               0     0.000000     1.398362     2.454162     2.300260 #> FAP                 0     0.000000     0.000000     0.000000     0.000000 #> GZMB                0     0.000000     0.000000     0.000000     0.000000 #> TSC2                0     0.000000     0.000000     0.000000     0.000000 #>          X25_Y-97..DC X26_Y-98..DC X28_Y-96..DC X65_Y-92..DC X64_Y-93..DC #> PDK4         3.516896     2.416839      4.69771     3.406335     4.887178 #> TNFRSF17     0.000000     0.000000      0.00000     0.000000     0.000000 #> ICAM3        4.195087     2.772998      0.00000     0.000000     0.000000 #> FAP          0.000000     0.000000      0.00000     0.000000     0.000000 #> GZMB         0.000000     0.000000      0.00000     0.000000     0.000000 #> TSC2         0.000000     0.000000      0.00000     0.000000     0.000000 #>          X64_Y-94..DC X62_Y-94..DC X61_Y-95..DC X61_Y-96..DC X55_Y-91..DC #> PDK4         2.443589            0            0     0.000000     0.000000 #> TNFRSF17     0.000000            0            0     0.000000     0.000000 #> ICAM3        2.238421            0            0     3.155804     0.000000 #> FAP          0.000000            0            0     0.000000     0.000000 #> GZMB         0.000000            0            0     0.000000     0.000000 #> TSC2         0.000000            0            0     0.000000     1.637539 #>          X57_Y-92..DC X58_Y-92..DC X59_Y-92..DC X55_Y-92..DC X57_Y-94..DC #> PDK4                0     1.858741     1.858741            0     0.000000 #> TNFRSF17            0     0.000000     0.000000            0     0.000000 #> ICAM3               0     2.199204     2.199204            0     4.141856 #> FAP                 0     0.000000     0.000000            0     0.000000 #> GZMB                0     0.000000     0.000000            0     0.000000 #> TSC2                0     0.000000     0.000000            0     0.000000 #>          X55_Y-94..DC X56_Y-95..DC X57_Y-96..DC X58_Y-96..DC X57_Y-97..DC #> PDK4         2.105524            0     4.095820     1.694787     2.047910 #> TNFRSF17     0.000000            0     0.000000     0.000000     0.000000 #> ICAM3        1.167787            0     1.837663     1.694787     1.782712 #> FAP          0.000000            0     0.000000     0.000000     0.000000 #> GZMB         0.000000            0     0.000000     0.000000     0.000000 #> TSC2         0.000000            0     0.000000     1.694787     0.000000 #>          X59_Y-96..DC X56_Y-96..DC X76_Y-100..DC X73_Y-100..DC X74_Y-101..DC #> PDK4                0            0      0.000000      0.000000       4.38658 #> TNFRSF17            0            0      0.000000      0.000000       0.00000 #> ICAM3               0            0      0.000000      4.214594       0.00000 #> FAP                 0            0      0.000000      0.000000       0.00000 #> GZMB                0            0      3.811077      0.000000       0.00000 #> TSC2                0            0      0.000000      0.000000       0.00000 #>          X77_Y-102..DC X78_Y-85..DC X74_Y-86..DC X75_Y-86..DC X74_Y-87..DC #> PDK4                 0     1.923706     0.000000     0.000000            0 #> TNFRSF17             0     0.000000     0.000000     0.000000            0 #> ICAM3                0     2.264917     5.333615     2.201191            0 #> FAP                  0     0.000000     0.000000     0.000000            0 #> GZMB                 0     0.000000     0.000000     0.000000            0 #> TSC2                 0     0.000000     0.000000     0.000000            0 #>          X75_Y-88..DC X73_Y-90..DC X72_Y-87..DC X32_Y-74..DC X42_Y-66..DC #> PDK4         0.000000    0.9188316     2.288148     2.213289     2.057408 #> TNFRSF17     0.000000    0.0000000     0.000000     0.000000     0.000000 #> ICAM3        4.163422    2.0801523     0.000000     2.209223     2.060380 #> FAP          0.000000    0.0000000     0.000000     0.000000     0.000000 #> GZMB         0.000000    0.0000000     0.000000     0.000000     0.000000 #> TSC2         0.000000    0.0000000     0.000000     0.000000     0.000000 #>          X41_Y-69..DC X39_Y-70..DC X39_Y-74..DC X40_Y-75..DC X39_Y-75..DC #> PDK4         1.143054     3.186429     4.010973     4.129745     3.679083 #> TNFRSF17     0.000000     0.000000     0.000000     0.000000     0.000000 #> ICAM3        2.923962     0.000000     0.000000     3.452557     3.679083 #> FAP          0.000000     0.000000     0.000000     0.000000     0.000000 #> GZMB         0.000000     0.000000     0.000000     0.000000     0.000000 #> TSC2         0.000000     0.000000     0.000000     0.000000     0.000000 #>          X37_Y-76..DC X40_Y-76..DC X37_Y-77..DC X73_Y-75..DC X60_Y-70..DC #> PDK4         0.000000     0.000000     1.750587            0     0.000000 #> TNFRSF17     0.000000     0.000000     0.000000            0     0.000000 #> ICAM3        3.101507     3.888691     1.901769            0     4.333204 #> FAP          0.000000     0.000000     0.000000            0     0.000000 #> GZMB         0.000000     0.000000     0.000000            0     0.000000 #> TSC2         0.000000     0.000000     0.000000            0     0.000000 #>          X73_Y-76..DC X72_Y-75..DC X54_Y-78..DC X69_Y-69..DC X72_Y-69..DC #> PDK4         0.000000            0     0.000000     0.000000     4.303966 #> TNFRSF17     0.000000            0     0.000000     0.000000     0.000000 #> ICAM3        5.235994            0     2.148396     4.532863     0.000000 #> FAP          0.000000            0     0.000000     0.000000     0.000000 #> GZMB         0.000000            0     0.000000     0.000000     0.000000 #> TSC2         0.000000            0     0.000000     0.000000     0.000000 #>          X48_Y-79..DC X54_Y-79..DC X52_Y-73..DC X53_Y-74..DC X54_Y-77..DC #> PDK4         1.402683     0.000000     0.000000            0            0 #> TNFRSF17     0.000000     0.000000     0.000000            0            0 #> ICAM3        1.416001     2.148396     4.585859            0            0 #> FAP          0.000000     0.000000     0.000000            0            0 #> GZMB         0.000000     0.000000     0.000000            0            0 #> TSC2         0.000000     0.000000     0.000000            0            0 #>          X46_Y-91..DC X43_Y-92..DC X42_Y-92..DC X44_Y-92..DC X45_Y-92..DC #> PDK4                0    0.0000000    0.0000000     0.000000     0.000000 #> TNFRSF17            0    0.0000000    0.0000000     0.000000     0.000000 #> ICAM3               0    0.8653708    0.8947885     3.461483     2.288148 #> FAP                 0    0.0000000    0.0000000     0.000000     0.000000 #> GZMB                0    0.0000000    0.0000000     0.000000     0.000000 #> TSC2                0    0.0000000    0.0000000     0.000000     0.000000 #>          X42_Y-93..DC X43_Y-93..DC X44_Y-93..DC X44_Y-94..DC X42_Y-94..DC #> PDK4                0            0     0.000000     0.000000            0 #> TNFRSF17            0            0     0.000000     0.000000            0 #> ICAM3               0            0     2.262653     2.393944            0 #> FAP                 0            0     0.000000     0.000000            0 #> GZMB                0            0     0.000000     0.000000            0 #> TSC2                0            0     0.000000     0.000000            0 #>          X46_Y-95..DC X43_Y-95..DC X44_Y-95..DC X45_Y-95..DC X42_Y-95..DC #> PDK4         0.000000     0.000000     0.000000       0.0000     0.000000 #> TNFRSF17     0.000000     0.000000     0.000000       0.0000     0.000000 #> ICAM3        1.281723     1.112847     1.483796       0.0000     1.708544 #> FAP          0.000000     0.000000     0.000000       0.0000     0.000000 #> GZMB         0.000000     0.000000     1.215267       1.8229     0.000000 #> TSC2         0.000000     0.000000     0.000000       0.0000     0.000000 #>          X42_Y-96..DC X44_Y-96..DC X47_Y-97..DC X46_Y-92..DC X45_Y-93..DC #> PDK4          0.00000            0       4.0972            0     0.000000 #> TNFRSF17      0.00000            0       0.0000            0     0.000000 #> ICAM3         1.53776            0       0.0000            0     2.262653 #> FAP           0.00000            0       0.0000            0     0.000000 #> GZMB          0.00000            0       0.0000            0     0.000000 #> TSC2          0.00000            0       0.0000            0     0.000000 #>          X46_Y-96..DC X25_Y-74..DC X26_Y-78..DC X35_Y-70..DC X30_Y-80..DC #> PDK4         4.348158     0.000000     3.038826            0     3.664146 #> TNFRSF17     0.000000     0.000000     0.000000            0     0.000000 #> ICAM3        0.000000     4.234501     3.038826            0     0.000000 #> FAP          0.000000     0.000000     0.000000            0     0.000000 #> GZMB         0.000000     0.000000     0.000000            0     0.000000 #> TSC2         0.000000     0.000000     0.000000            0     0.000000 #>          X24_Y-66..DC X24_Y-67..DC X28_Y-72..DC X25_Y-72..DC X22_Y-83..DC #> PDK4         1.236559     1.236559     2.155597            0            0 #> TNFRSF17     0.000000     0.000000     0.000000            0            0 #> ICAM3        2.797121     2.797121     2.155597            0            0 #> FAP          0.000000     0.000000     0.000000            0            0 #> GZMB         0.000000     0.000000     0.000000            0            0 #> TSC2         0.000000     0.000000     0.000000            0            0 #>          X23_Y-80..DC X22_Y-85..DC X46_Y-64..DC X46_Y-65..DC X47_Y-65..DC #> PDK4                0       2.0231     1.308167     1.308167            0 #> TNFRSF17            0       0.0000     0.000000     0.000000            0 #> ICAM3               0       0.0000     2.555106     2.555106            0 #> FAP                 0       0.0000     0.000000     0.000000            0 #> GZMB                0       0.0000     0.000000     0.000000            0 #> TSC2                0       0.0000     0.000000     0.000000            0 #>          X44_Y-65..DC X47_Y-66..DC X45_Y-66..DC X46_Y-67..DC X51_Y-65..DC #> PDK4         0.000000       0.0000     0.000000     2.084836            0 #> TNFRSF17     0.000000       0.0000     0.000000     0.000000            0 #> ICAM3        3.197619       2.0371     1.852899     0.000000            0 #> FAP          0.000000       0.0000     0.000000     0.000000            0 #> GZMB         0.000000       0.0000     0.000000     0.000000            0 #> TSC2         0.000000       0.0000     0.000000     0.000000            0 #>          X52_Y-66..DC X51_Y-67..DC X53_Y-65..DC X51_Y-66..DC X49_Y-66..DC #> PDK4                0     1.732239            0            0     1.733741 #> TNFRSF17            0     0.000000            0            0     0.000000 #> ICAM3               0     1.799849            0            0     1.733741 #> FAP                 0     0.000000            0            0     0.000000 #> GZMB                0     0.000000            0            0     0.000000 #> TSC2                0     0.000000            0            0     0.000000 #>          X36_Y-79..DC X37_Y-80..DC X37_Y-82..DC X42_Y-83..DC X36_Y-83..DC #> PDK4         2.463577     4.635125     2.900527            0     0.000000 #> TNFRSF17     0.000000     0.000000     0.000000            0     0.000000 #> ICAM3        0.000000     4.635125     0.000000            0     1.377586 #> FAP          0.000000     0.000000     0.000000            0     0.000000 #> GZMB         0.000000     0.000000     0.000000            0     0.000000 #> TSC2         0.000000     0.000000     0.000000            0     0.000000 #>          X36_Y-84..DC X39_Y-84..DC X44_Y-73..DC X45_Y-73..DC X44_Y-74..DC #> PDK4         0.000000            0     1.830224     0.000000     1.830224 #> TNFRSF17     0.000000            0     0.000000     0.000000     0.000000 #> ICAM3        1.377586            0     1.860705     3.819994     0.000000 #> FAP          0.000000            0     0.000000     0.000000     0.000000 #> GZMB         0.000000            0     0.000000     0.000000     0.000000 #> TSC2         0.000000            0     0.000000     0.000000     0.000000 #>          X45_Y-74..DC X43_Y-74..DC X44_Y-75..DC X46_Y-75..DC X44_Y-76..DC #> PDK4         0.000000            0            0      0.00000     0.000000 #> TNFRSF17     0.000000            0            0      0.00000     0.000000 #> ICAM3        4.138814            0            0      1.28397     4.595516 #> FAP          0.000000            0            0      0.00000     0.000000 #> GZMB         0.000000            0            0      0.00000     0.000000 #> TSC2         0.000000            0            0      0.00000     0.000000 #>          X47_Y-77..DC X46_Y-77..DC X47_Y-78..DC X47_Y-75..DC X45_Y-77..DC #> PDK4         2.157414     1.438276     0.000000            0     0.000000 #> TNFRSF17     0.000000     0.000000     0.000000            0     0.000000 #> ICAM3        1.817480     2.889927     3.926936            0     5.034819 #> FAP          0.000000     0.000000     0.000000            0     0.000000 #> GZMB         0.000000     0.000000     0.000000            0     0.000000 #> TSC2         0.000000     0.000000     0.000000            0     0.000000 #>          X43_Y-78..DC X76_Y-82..DC X77_Y-85..DC X76_Y-85..DC X75_Y-80..DC #> PDK4         3.782335      0.00000     0.000000     0.000000            0 #> TNFRSF17     0.000000      0.00000     0.000000     0.000000            0 #> ICAM3        0.000000      4.70854     4.067964     4.067964            0 #> FAP          0.000000      0.00000     0.000000     0.000000            0 #> GZMB         0.000000      0.00000     0.000000     0.000000            0 #> TSC2         3.782335      0.00000     0.000000     0.000000            0 #>          X75_Y-69..DC X75_Y-70..DC X77_Y-71..DC X73_Y-71..DC X73_Y-70..DC #> PDK4         4.402383     2.201191            0     0.000000            0 #> TNFRSF17     0.000000     0.000000            0     0.000000            0 #> ICAM3        3.721409     1.860705            0     2.536743            0 #> FAP          0.000000     0.000000            0     0.000000            0 #> GZMB         0.000000     0.000000            0     0.000000            0 #> TSC2         0.000000     0.000000            0     0.000000            0 #>          X60_Y-68..DC X59_Y-68..DC X58_Y-69..DC X58_Y-66..DC X47_Y-79..DC #> PDK4         1.541691     0.000000     4.333204            0     2.104024 #> TNFRSF17     0.000000     0.000000     0.000000            0     0.000000 #> ICAM3        2.814321     4.221481     0.000000            0     0.000000 #> FAP          0.000000     0.000000     0.000000            0     0.000000 #> GZMB         0.000000     0.000000     0.000000            0     0.000000 #> TSC2         0.000000     0.000000     0.000000            0     0.000000 #>          X44_Y-80..DC X43_Y-80..DC X46_Y-80..DC X44_Y-82..DC X43_Y-83..DC #> PDK4         0.000000            0     0.000000     0.000000    0.7938436 #> TNFRSF17     0.000000            0     0.000000     0.000000    0.0000000 #> ICAM3        1.919237            0     3.922071     1.768058    0.0000000 #> FAP          0.000000            0     0.000000     0.000000    0.0000000 #> GZMB         0.000000            0     0.000000     0.000000    0.0000000 #> TSC2         0.000000            0     0.000000     0.000000    0.0000000 #>          X43_Y-84..DC X42_Y-84..DC X43_Y-85..DC X49_Y-91..DC X51_Y-93..DC #> PDK4         1.686553     3.596243     2.012185     0.000000            0 #> TNFRSF17     0.000000     0.000000     0.000000     0.000000            0 #> ICAM3        0.000000     3.596243     0.000000     3.971863            0 #> FAP          0.000000     0.000000     0.000000     0.000000            0 #> GZMB         0.000000     0.000000     0.000000     0.000000            0 #> TSC2         0.000000     0.000000     0.000000     0.000000            0 #>          X72_Y-82..DC X73_Y-83..DC X70_Y-84..DC X71_Y-85..DC X71_Y-79..DC #> PDK4                0            0            0     4.163422            0 #> TNFRSF17            0            0            0     0.000000            0 #> ICAM3               0            0            0     4.163422            0 #> FAP                 0            0            0     0.000000            0 #> GZMB                0            0            0     0.000000            0 #> TSC2                0            0            0     0.000000            0 #>          X49_Y-67..DC X48_Y-67..DC X48_Y-68..DC X50_Y-69..DC X51_Y-70..DC #> PDK4         1.155827     0.000000     0.000000     1.577902            0 #> TNFRSF17     0.000000     0.000000     0.000000     0.000000            0 #> ICAM3        3.443030     3.430805     1.812122     4.041122            0 #> FAP          0.000000     0.000000     0.000000     0.000000            0 #> GZMB         0.000000     0.000000     0.000000     0.000000            0 #> TSC2         0.000000     0.000000     0.000000     0.000000            0 #>          X50_Y-68..DC X49_Y-69..DC X56_Y-81..DC X59_Y-82..DC X59_Y-84..DC #> PDK4                0     3.155804     0.000000            0            0 #> TNFRSF17            0     0.000000     0.000000            0            0 #> ICAM3               0     3.827419     4.348158            0            0 #> FAP                 0     0.000000     0.000000            0            0 #> GZMB                0     0.000000     0.000000            0            0 #> TSC2                0     0.000000     0.000000            0            0 #>          X60_Y-85..DC X55_Y-80..DC X56_Y-82..DC X62_Y-84..DC X35_Y-91..DC #> PDK4                0            0            0            0     0.000000 #> TNFRSF17            0            0            0            0     0.000000 #> ICAM3               0            0            0            0     4.111455 #> FAP                 0            0            0            0     0.000000 #> GZMB                0            0            0            0     0.000000 #> TSC2                0            0            0            0     0.000000 #>          X35_Y-93..DC X34_Y-93..DC X35_Y-94..DC X34_Y-94..DC X36_Y-94..DC #> PDK4        1.6697617     2.226349            0            0     0.000000 #> TNFRSF17    0.0000000     0.000000            0            0     0.000000 #> ICAM3       0.9866613     1.315548            0            0     3.726738 #> FAP         0.0000000     0.000000            0            0     0.000000 #> GZMB        0.0000000     0.000000            0            0     2.378450 #> TSC2        0.0000000     0.000000            0            0     0.000000 #>          X34_Y-96..DC X35_Y-97..DC X42_Y-85..DC X42_Y-86..DC X45_Y-87..DC #> PDK4         3.893389     0.000000     2.822118     0.000000            0 #> TNFRSF17     0.000000     0.000000     0.000000     0.000000            0 #> ICAM3        3.220413     3.860974     3.010429     3.841744            0 #> FAP          0.000000     0.000000     0.000000     0.000000            0 #> GZMB         0.000000     0.000000     0.000000     0.000000            0 #> TSC2         0.000000     0.000000     0.000000     0.000000            0 #>          X44_Y-88..DC X45_Y-89..DC X45_Y-90..DC X44_Y-90..DC X42_Y-91..DC #> PDK4         3.847411     2.127412     4.254824      0.00000     0.000000 #> TNFRSF17     0.000000     0.000000     0.000000      0.00000     0.000000 #> ICAM3        3.847411     1.673146     0.000000      2.03995     2.620585 #> FAP          0.000000     0.000000     0.000000      0.00000     0.000000 #> GZMB         0.000000     0.000000     0.000000      0.00000     0.000000 #> TSC2         0.000000     0.000000     0.000000      0.00000     0.000000 #>          X46_Y-89..DC X47_Y-89..DC X47_Y-90..DC X53_Y-80..DC X52_Y-80..DC #> PDK4         4.494189            0            0     0.000000     0.000000 #> TNFRSF17     0.000000            0            0     0.000000     0.000000 #> ICAM3        0.000000            0            0     4.459799     2.229899 #> FAP          0.000000            0            0     0.000000     0.000000 #> GZMB         0.000000            0            0     0.000000     0.000000 #> TSC2         0.000000            0            0     0.000000     0.000000 #>          X51_Y-81..DC X52_Y-79..DC X52_Y-84..DC X70_Y-92..DC X72_Y-92..DC #> PDK4                0       0.0000            0     0.000000     3.559047 #> TNFRSF17            0       0.0000            0     0.000000     0.000000 #> ICAM3               0       1.4866            0     4.473981     4.237859 #> FAP                 0       0.0000            0     0.000000     0.000000 #> GZMB                0       0.0000            0     0.000000     0.000000 #> TSC2                0       0.0000            0     0.000000     0.000000 #>          X69_Y-92..DC X70_Y-95..DC X68_Y-97..DC X76_Y-92..DC X75_Y-92..DC #> PDK4                0            0     0.000000     0.000000     4.589067 #> TNFRSF17            0            0     0.000000     0.000000     0.000000 #> ICAM3               0            0     2.031452     2.521216     3.510576 #> FAP                 0            0     0.000000     0.000000     0.000000 #> GZMB                0            0     0.000000     0.000000     0.000000 #> TSC2                0            0     0.000000     0.000000     0.000000 #>          X74_Y-96..DC X73_Y-93..DC X74_Y-93..DC X74_Y-97..DC X42_Y-67..DC #> PDK4         4.418446     0.000000     0.000000            0     4.114816 #> TNFRSF17     0.000000     0.000000     0.000000            0     0.000000 #> ICAM3        4.418446     0.000000     0.000000            0     0.000000 #> FAP          0.000000     0.000000     0.000000            0     0.000000 #> GZMB         0.000000     0.000000     0.000000            0     0.000000 #> TSC2         0.000000     1.828383     1.828383            0     0.000000 #>          X46_Y-68..DC X47_Y-69..DC X45_Y-70..DC X47_Y-71..DC X46_Y-71..DC #> PDK4         0.000000            0     3.615404     0.000000     2.221523 #> TNFRSF17     0.000000            0     0.000000     0.000000     0.000000 #> ICAM3        0.000000            0     4.011860     2.855714     0.000000 #> FAP          0.000000            0     0.000000     0.000000     0.000000 #> GZMB         2.166602            0     0.000000     0.000000     0.000000 #> TSC2         0.000000            0     0.000000     0.000000     0.000000 #>          X45_Y-72..DC X43_Y-68..DC X48_Y-70..DC X28_Y-88..DC X26_Y-91..DC #> PDK4                0            0     0.000000     4.195087            0 #> TNFRSF17            0            0     0.000000     0.000000            0 #> ICAM3               0            0     3.307465     0.000000            0 #> FAP                 0            0     0.000000     0.000000            0 #> GZMB                0            0     0.000000     0.000000            0 #> TSC2                0            0     0.000000     0.000000            0 #>          X33_Y-86..DC X34_Y-90..DC X33_Y-89..DC X37_Y-89..DC X39_Y-91..DC #> PDK4         3.122011     1.600965     0.000000     2.908595     3.069454 #> TNFRSF17     0.000000     0.000000     0.000000     0.000000     0.000000 #> ICAM3        3.122011     2.304688     5.199492     4.253114     2.231309 #> FAP          0.000000     0.000000     0.000000     0.000000     0.000000 #> GZMB         0.000000     0.000000     0.000000     0.000000     0.000000 #> TSC2         0.000000     0.000000     0.000000     0.000000     1.363459 #>          X36_Y-91..DC X36_Y-87..DC X36_Y-88..DC X38_Y-90..DC X34_Y-100..DC #> PDK4         0.000000            0            0            0      0.000000 #> TNFRSF17     0.000000            0            0            0      0.000000 #> ICAM3        4.045108            0            0            0      3.660449 #> FAP          0.000000            0            0            0      0.000000 #> GZMB         0.000000            0            0            0      0.000000 #> TSC2         0.000000            0            0            0      0.000000 #>          X31_Y-101..DC X30_Y-102..DC X33_Y-103..DC X34_Y-103..DC X30_Y-103..DC #> PDK4          0.000000      3.755482      0.000000             0      3.661595 #> TNFRSF17      0.000000      0.000000      0.000000             0      0.000000 #> ICAM3         3.253301      3.755482      2.411215             0      4.198737 #> FAP           0.000000      0.000000      0.000000             0      0.000000 #> GZMB          0.000000      0.000000      0.000000             0      0.000000 #> TSC2          0.000000      0.000000      0.000000             0      0.000000 #>          X32_Y-103..DC X22_Y-86..DC X22_Y-87..DC X23_Y-99..DC X27_Y-98..DC #> PDK4         0.6393755     0.000000            0     4.074201     1.555851 #> TNFRSF17     0.0000000     0.000000            0     0.000000     0.000000 #> ICAM3        2.0093461     4.760721            0     4.074201     2.090090 #> FAP          0.0000000     0.000000            0     0.000000     0.000000 #> GZMB         0.0000000     0.000000            0     0.000000     0.000000 #> TSC2         0.0000000     0.000000            0     0.000000     0.000000 #>          X27_Y-101..DC X28_Y-101..DC X30_Y-101..DC X28_Y-102..DC X28_Y-103..DC #> PDK4                 0      3.494957      1.755288      0.000000     0.7242994 #> TNFRSF17             0      0.000000      0.000000      0.000000     0.0000000 #> ICAM3                0      4.858226      3.381939      3.926936     1.9713169 #> FAP                  0      0.000000      0.000000      0.000000     0.0000000 #> GZMB                 0      0.000000      0.000000      0.000000     0.7242994 #> TSC2                 0      0.000000      0.000000      0.000000     0.7242994 #>          X28_Y-104..DC X74_Y-104..DC X73_Y-107..DC X74_Y-105..DC X61_Y-100..DC #> PDK4          0.000000      0.000000      0.000000             0      1.644943 #> TNFRSF17      0.000000      0.000000      0.000000             0      0.000000 #> ICAM3         1.597936      1.562044      0.000000             0      4.150043 #> FAP           0.000000      0.000000      0.000000             0      0.000000 #> GZMB          0.000000      0.000000      2.242739             0      0.000000 #> TSC2          0.000000      0.000000      0.000000             0      0.000000 #>          X63_Y-100..DC X64_Y-101..DC X63_Y-101..DC X61_Y-102..DC X62_Y-104..DC #> PDK4          4.508691      4.146185      1.512984      0.000000             0 #> TNFRSF17      0.000000      0.000000      0.000000      0.000000             0 #> ICAM3         2.120614      4.486864      1.512984      4.405041             0 #> FAP           0.000000      0.000000      0.000000      0.000000             0 #> GZMB          0.000000      2.269476      1.512984      0.000000             0 #> TSC2          0.000000      0.000000      0.000000      0.000000             0 #>          X61_Y-101..DC X62_Y-101..DC X22_Y-105..DC X22_Y-107..DC X72_Y-86..DC #> PDK4           0.00000             0             0      0.000000     0.000000 #> TNFRSF17       0.00000             0             0      0.000000     0.000000 #> ICAM3          3.93674             0             0      2.509883     3.879363 #> FAP            0.00000             0             0      0.000000     0.000000 #> GZMB           0.00000             0             0      0.000000     0.000000 #> TSC2           0.00000             0             0      0.000000     3.879363 #>          X70_Y-86..DC X68_Y-87..DC X68_Y-88..DC X70_Y-89..DC X72_Y-90..DC #> PDK4                0            0     2.234142     4.363345     1.837663 #> TNFRSF17            0            0     0.000000     0.000000     0.000000 #> ICAM3               0            0     4.318978     0.000000     1.837663 #> FAP                 0            0     0.000000     0.000000     0.000000 #> GZMB                0            0     0.000000     0.000000     0.000000 #> TSC2                0            0     0.000000     0.000000     0.000000 #>          X72_Y-89..DC X25_Y-104..DC X24_Y-105..DC X27_Y-105..DC X25_Y-105..DC #> PDK4                0      4.430669      0.000000        0.0000      0.000000 #> TNFRSF17            0      0.000000      0.000000        0.0000      0.000000 #> ICAM3               0      0.000000      3.494957        1.7248      2.608787 #> FAP                 0      0.000000      0.000000        0.0000      0.000000 #> GZMB                0      0.000000      0.000000        0.0000      0.000000 #> TSC2                0      0.000000      0.000000        0.0000      0.000000 #>          X27_Y-106..DC X25_Y-106..DC X28_Y-106..DC X26_Y-106..DC X25_Y-107..DC #> PDK4            0.0000      2.816016      2.517409      1.839541     0.7358165 #> TNFRSF17        0.0000      0.000000      0.000000      0.000000     0.0000000 #> ICAM3           1.7248      1.216480      2.174079      1.839541     0.7358165 #> FAP             0.0000      0.000000      0.000000      0.000000     0.0000000 #> GZMB            0.0000      0.000000      0.000000      1.901769     0.7607077 #> TSC2            0.0000      0.000000      0.000000      0.000000     0.0000000 #>          X26_Y-107..DC X69_Y-99..DC X67_Y-102..DC X72_Y-102..DC X69_Y-102..DC #> PDK4         0.9197706            0             0      0.000000      2.137791 #> TNFRSF17     0.0000000            0             0      0.000000      0.000000 #> ICAM3        0.9197706            0             0      4.665919      4.808650 #> FAP          0.0000000            0             0      0.000000      0.000000 #> GZMB         0.9508847            0             0      0.000000      0.000000 #> TSC2         0.0000000            0             0      0.000000      0.000000 #>          X73_Y-103..DC X71_Y-101..DC X70_Y-105..DC X72_Y-105..DC X68_Y-105..DC #> PDK4                 0             0             0             0      4.241228 #> TNFRSF17             0             0             0             0      0.000000 #> ICAM3                0             0             0             0      4.241228 #> FAP                  0             0             0             0      0.000000 #> GZMB                 0             0             0             0      0.000000 #> TSC2                 0             0             0             0      0.000000 #>          X71_Y-106..DC X72_Y-106..DC X65_Y-107..DC X64_Y-106..DC X53_Y-104..DC #> PDK4           0.00000      0.000000             0             0      0.000000 #> TNFRSF17       0.00000      0.000000             0             0      0.000000 #> ICAM3          4.18867      4.494189             0             0      4.374893 #> FAP            0.00000      0.000000             0             0      0.000000 #> GZMB           0.00000      0.000000             0             0      0.000000 #> TSC2           0.00000      0.000000             0             0      0.000000 #>          X49_Y-104..DC X54_Y-105..DC X49_Y-105..DC X48_Y-106..DC X53_Y-105..DC #> PDK4          4.018989      0.000000      2.009494      0.000000      2.034268 #> TNFRSF17      0.000000      0.000000      0.000000      0.000000      0.000000 #> ICAM3         0.000000      3.741288      2.185514      2.332959      4.563994 #> FAP           0.000000      0.000000      0.000000      0.000000      0.000000 #> GZMB          0.000000      0.000000      0.000000      0.000000      0.000000 #> TSC2          0.000000      0.000000      0.000000      0.000000      0.000000 #>          X33_Y-104..DC X32_Y-104..DC X34_Y-104..DC X30_Y-105..DC X30_Y-106..DC #> PDK4          0.000000      1.278751             0      4.013637      2.006819 #> TNFRSF17      0.000000      0.000000             0      0.000000      0.000000 #> ICAM3         3.858725      2.572483             0      4.013637      2.006819 #> FAP           0.000000      0.000000             0      0.000000      0.000000 #> GZMB          0.000000      0.000000             0      0.000000      0.000000 #> TSC2          0.000000      0.000000             0      0.000000      0.000000 #>          X30_Y-107..DC X29_Y-107..DC X35_Y-104..DC X34_Y-106..DC X34_Y-107..DC #> PDK4          0.000000      0.000000      4.451387      4.371029      2.185514 #> TNFRSF17      0.000000      0.000000      0.000000      0.000000      0.000000 #> ICAM3         4.511964      4.511964      0.000000      0.000000      2.060380 #> FAP           0.000000      0.000000      0.000000      0.000000      0.000000 #> GZMB          0.000000      0.000000      0.000000      0.000000      0.000000 #> TSC2          0.000000      0.000000      0.000000      0.000000      0.000000 #>          X58_Y-97..DC X59_Y-98..DC X55_Y-98..DC X56_Y-98..DC X56_Y-99..DC #> PDK4                0     0.000000      0.00000            0            0 #> TNFRSF17            0     0.000000      0.00000            0            0 #> ICAM3               0     3.874733      3.79926            0            0 #> FAP                 0     0.000000      0.00000            0            0 #> GZMB                0     0.000000      0.00000            0            0 #> TSC2                0     0.000000      0.00000            0            0 #>          X55_Y-100..DC X58_Y-100..DC X57_Y-100..DC X56_Y-101..DC X59_Y-103..DC #> PDK4           0.00000      1.749030      0.000000      0.000000      0.000000 #> TNFRSF17       0.00000      0.000000      0.000000      0.000000      0.000000 #> ICAM3          3.00427      4.632675      5.089387      3.239978      0.000000 #> FAP            0.00000      0.000000      0.000000      0.000000      0.000000 #> GZMB           0.00000      0.000000      0.000000      0.000000      4.157211 #> TSC2           0.00000      1.749030      0.000000      0.000000      0.000000 #>          X59_Y-99..DC X56_Y-100..DC X59_Y-102..DC X57_Y-103..DC X41_Y-98..DC #> PDK4                0             0      0.000000             0     0.000000 #> TNFRSF17            0             0      0.000000             0     0.000000 #> ICAM3               0             0      0.000000             0     2.127412 #> FAP                 0             0      0.000000             0     0.000000 #> GZMB                0             0      2.078606             0     0.000000 #> TSC2                0             0      0.000000             0     0.000000 #>          X39_Y-98..DC X40_Y-99..DC X38_Y-99..DC X42_Y-100..DC X38_Y-100..DC #> PDK4                0            0            0      0.000000       1.77331 #> TNFRSF17            0            0            0      0.000000       0.00000 #> ICAM3               0            0            0      4.008316       1.77331 #> FAP                 0            0            0      0.000000       0.00000 #> GZMB                0            0            0      0.000000       0.00000 #> TSC2                0            0            0      0.000000       0.00000 #>          X39_Y-100..DC X38_Y-101..DC X41_Y-102..DC X41_Y-103..DC X41_Y-104..DC #> PDK4            0.0000      1.042751      0.000000      0.000000     0.8425977 #> TNFRSF17        0.0000      0.000000      0.000000      0.000000     0.0000000 #> ICAM3           1.7248      0.000000      4.645283      4.742853     1.0115501 #> FAP             0.0000      0.000000      0.000000      0.000000     0.0000000 #> GZMB            0.0000      0.000000      0.000000      0.000000     0.0000000 #> TSC2            0.0000      0.000000      0.000000      0.000000     0.0000000 #>          X66_Y-87..DC X62_Y-88..DC X64_Y-90..DC X65_Y-90..DC X62_Y-91..DC #> PDK4                0     0.000000     0.000000     3.825224     0.000000 #> TNFRSF17            0     0.000000     0.000000     0.000000     0.000000 #> ICAM3               0     3.884015     1.325662     3.825224     2.335573 #> FAP                 0     0.000000     0.000000     0.000000     0.000000 #> GZMB                0     3.884015     0.000000     0.000000     0.000000 #> TSC2                0     0.000000     0.000000     0.000000     0.000000 #>          X66_Y-91..DC X66_Y-86..DC X62_Y-86..DC X63_Y-87..DC X41_Y-91..DC #> PDK4                0            0       4.0972            0            0 #> TNFRSF17            0            0       0.0000            0            0 #> ICAM3               0            0       0.0000            0            0 #> FAP                 0            0       0.0000            0            0 #> GZMB                0            0       0.0000            0            0 #> TSC2                0            0       0.0000            0            0 #>          X40_Y-91..DC X37_Y-92..DC X37_Y-93..DC X40_Y-93..DC X36_Y-93..DC #> PDK4         3.411989     0.000000     0.000000     0.000000     0.000000 #> TNFRSF17     0.000000     0.000000     0.000000     0.000000     0.000000 #> ICAM3        0.000000     3.367717     3.517465     3.029411     3.675326 #> FAP          0.000000     0.000000     0.000000     0.000000     0.000000 #> GZMB         0.000000     0.000000     2.378450     0.000000     4.756900 #> TSC2         0.000000     0.000000     0.000000     0.000000     0.000000 #>          X41_Y-94..DC X41_Y-95..DC X39_Y-95..DC X39_Y-96..DC X41_Y-96..DC #> PDK4                0     0.000000            0    0.9733472      0.00000 #> TNFRSF17            0     0.000000            0    0.0000000      0.00000 #> ICAM3               0     1.270718            0    0.9733472      1.53776 #> FAP                 0     0.000000            0    0.0000000      0.00000 #> GZMB                0     0.000000            0    0.0000000      0.00000 #> TSC2                0     0.000000            0    0.0000000      0.00000 #>          X40_Y-94..DC X36_Y-95..DC X39_Y-104..DC X40_Y-104..DC X41_Y-105..DC #> PDK4         0.000000            0      3.782335     0.6740781      1.123464 #> TNFRSF17     0.000000            0      0.000000     0.0000000      0.000000 #> ICAM3        3.926936            0      0.000000     1.6685985      2.780998 #> FAP          0.000000            0      0.000000     0.0000000      0.000000 #> GZMB         0.000000            0      0.000000     0.0000000      0.000000 #> TSC2         0.000000            0      0.000000     0.0000000      0.000000 #>          X40_Y-105..DC X39_Y-105..DC X37_Y-106..DC X40_Y-106..DC X37_Y-105..DC #> PDK4          0.000000             0             0             0      0.000000 #> TNFRSF17      0.000000             0             0             0      0.000000 #> ICAM3         4.296792             0             0             0      3.624244 #> FAP           0.000000             0             0             0      0.000000 #> GZMB          0.000000             0             0             0      0.000000 #> TSC2          0.000000             0             0             0      0.000000 #>          X41_Y-106..DC X40_Y-107..DC X52_Y-86..DC X52_Y-88..DC X50_Y-89..DC #> PDK4          0.000000      0.000000            0     0.000000            0 #> TNFRSF17      0.000000      0.000000            0     0.000000            0 #> ICAM3         0.000000      1.833929            0     1.958616            0 #> FAP           0.000000      0.000000            0     0.000000            0 #> GZMB          0.000000      0.000000            0     0.000000            0 #> TSC2          4.108909      0.000000            0     0.000000            0 #>          X53_Y-85..DC X51_Y-86..DC X52_Y-87..DC X51_Y-88..DC X49_Y-88..DC #> PDK4                0            0            0     0.000000            0 #> TNFRSF17            0            0            0     0.000000            0 #> ICAM3               0            0            0     4.108909            0 #> FAP                 0            0            0     0.000000            0 #> GZMB                0            0            0     0.000000            0 #> TSC2                0            0            0     0.000000            0 #>          X57_Y-90..DC X55_Y-90..DC X61_Y-85..DC X48_Y-98..DC X48_Y-99..DC #> PDK4                0     0.000000            0     0.000000     0.000000 #> TNFRSF17            0     0.000000            0     0.000000     0.000000 #> ICAM3               0     0.000000            0     3.232025     1.616013 #> FAP                 0     0.000000            0     0.000000     0.000000 #> GZMB                0     0.000000            0     0.000000     0.000000 #> TSC2                0     3.275078            0     0.000000     0.000000 #>          X53_Y-98..DC X50_Y-100..DC X44_Y-97..DC X42_Y-98..DC X43_Y-99..DC #> PDK4                0             0     0.000000     0.000000     0.000000 #> TNFRSF17            0             0     0.000000     0.000000     0.000000 #> ICAM3               0             0     4.029781     4.254824     1.424967 #> FAP                 0             0     0.000000     0.000000     0.000000 #> GZMB                0             0     0.000000     0.000000     0.000000 #> TSC2                0             0     0.000000     0.000000     0.000000 #>          X42_Y-102..DC X43_Y-100..DC X29_Y-91..Endothelial #> PDK4                 0             0             0.3263064 #> TNFRSF17             0             0             0.0000000 #> ICAM3                0             0             0.0000000 #> FAP                  0             0             0.6866956 #> GZMB                 0             0             0.0000000 #> TSC2                 0             0             0.0000000 #>          X24_Y-91..Endothelial X26_Y-91..Endothelial X24_Y-92..Endothelial #> PDK4                 0.7863651                     0             0.6553043 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.0000000                     0             0.0000000 #> GZMB                 0.0000000                     0             0.0000000 #> TSC2                 0.0000000                     0             0.0000000 #>          X29_Y-92..Endothelial X29_Y-93..Endothelial X30_Y-93..Endothelial #> PDK4                 0.2890709             0.6807583             0.7752843 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.7609970             0.0000000             0.0000000 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X24_Y-94..Endothelial X24_Y-95..Endothelial X28_Y-95..Endothelial #> PDK4                   1.01391              1.267388             1.1033435 #> TNFRSF17               0.00000              0.000000             0.0000000 #> ICAM3                  0.00000              0.000000             0.0000000 #> FAP                    0.00000              0.000000             0.6215519 #> GZMB                   0.00000              0.000000             0.0000000 #> TSC2                   0.00000              0.000000             0.0000000 #>          X27_Y-95..Endothelial X28_Y-96..Endothelial X27_Y-96..Endothelial #> PDK4                 1.5680964             1.2354310             1.4916799 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.2392100             0.6829458             0.1674470 #> GZMB                 0.2902074             0.2293006             0.2031452 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X26_Y-96..Endothelial X27_Y-97..Endothelial X28_Y-97..Endothelial #> PDK4                 1.5732845             0.6812293             1.3317520 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.2232626             0.7934868             0.8832670 #> GZMB                 0.0000000             0.0000000             0.2998546 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X24_Y-97..Endothelial X26_Y-97..Endothelial X28_Y-92..Endothelial #> PDK4                 1.4524192              2.034485              1.182641 #> TNFRSF17             0.0000000              0.000000              0.000000 #> ICAM3                0.0000000              0.000000              0.000000 #> FAP                  0.4085627              0.000000              2.057124 #> GZMB                 0.0000000              0.000000              0.000000 #> TSC2                 0.2213704              0.000000              0.000000 #>          X24_Y-98..Endothelial X65_Y-91..Endothelial X63_Y-91..Endothelial #> PDK4                 0.4300587             0.5698954                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.0000000             0.1755673                     0 #> GZMB                 0.0000000             0.1755673                     0 #> TSC2                 0.2418141             0.0000000                     0 #>          X66_Y-91..Endothelial X66_Y-92..Endothelial X61_Y-92..Endothelial #> PDK4                 0.8949568             0.5422553                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.1667890             0.2227792                     0 #> GZMB                 0.3457467             0.1789577                     0 #> TSC2                 0.0000000             0.0000000                     0 #>          X67_Y-92..Endothelial X62_Y-92..Endothelial X67_Y-93..Endothelial #> PDK4                 0.3548393                     0             0.4137505 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.4059865                     0             0.0000000 #> GZMB                 0.0000000                     0             0.0000000 #> TSC2                 0.0000000                     0             0.0000000 #>          X60_Y-93..Endothelial X63_Y-93..Endothelial X61_Y-94..Endothelial #> PDK4                  2.665872                     0              0.896915 #> TNFRSF17              0.000000                     0              0.000000 #> ICAM3                 0.000000                     0              0.000000 #> FAP                   0.000000                     0              0.000000 #> GZMB                  0.000000                     0              0.000000 #> TSC2                  0.000000                     0              0.000000 #>          X64_Y-96..Endothelial X65_Y-96..Endothelial X62_Y-96..Endothelial #> PDK4                 0.2660383                     0             0.3071172 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.2984125                     0             0.3039720 #> GZMB                 0.0000000                     0             0.0000000 #> TSC2                 0.0000000                     0             0.0000000 #>          X67_Y-96..Endothelial X61_Y-96..Endothelial X63_Y-96..Endothelial #> PDK4                 1.6836266             0.3992524             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.8914254             0.3951636             0.0000000 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.8914254             0.0000000             0.4822616 #>          X66_Y-96..Endothelial X63_Y-97..Endothelial X64_Y-97..Endothelial #> PDK4                  1.584402               0.00000               0.00000 #> TNFRSF17              0.000000               0.00000               0.00000 #> ICAM3                 0.000000               0.00000               0.00000 #> FAP                   0.000000               1.20599               1.20599 #> GZMB                  0.000000               0.00000               0.00000 #> TSC2                  0.000000               0.00000               0.00000 #>          X65_Y-98..Endothelial X64_Y-93..Endothelial X61_Y-93..Endothelial #> PDK4                 0.0000000                     0              0.896915 #> TNFRSF17             0.0000000                     0              0.000000 #> ICAM3                0.0000000                     0              0.000000 #> FAP                  0.8711444                     0              0.000000 #> GZMB                 0.0000000                     0              0.000000 #> TSC2                 0.0000000                     0              0.000000 #>          X63_Y-94..Endothelial X62_Y-94..Endothelial X64_Y-95..Endothelial #> PDK4                 0.9250144              1.541691             0.3144089 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.0000000              0.000000             0.3526693 #> GZMB                 0.0000000              0.000000             0.0000000 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X55_Y-91..Endothelial X58_Y-92..Endothelial X58_Y-93..Endothelial #> PDK4                 2.0473180              0.000000             0.8900206 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.5445555              3.721409             0.8900206 #> GZMB                 0.2421124              0.000000             0.0000000 #> TSC2                 0.2578671              0.000000             0.8900206 #>          X55_Y-93..Endothelial X59_Y-93..Endothelial X58_Y-94..Endothelial #> PDK4                 0.8319928              1.801583             1.4692927 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  1.8243206              0.000000             0.5340123 #> GZMB                 0.0000000              0.000000             0.0000000 #> TSC2                 0.0000000              0.000000             0.5340123 #>          X55_Y-95..Endothelial X59_Y-95..Endothelial X54_Y-95..Endothelial #> PDK4                         0              1.011567              0.000000 #> TNFRSF17                     0              0.000000              0.000000 #> ICAM3                        0              0.000000              0.000000 #> FAP                          0              0.000000              0.000000 #> GZMB                         0              0.000000              0.759852 #> TSC2                         0              0.000000              0.000000 #>          X58_Y-95..Endothelial X56_Y-95..Endothelial X56_Y-96..Endothelial #> PDK4                         0                     0              2.787984 #> TNFRSF17                     0                     0              0.000000 #> ICAM3                        0                     0              0.000000 #> FAP                          0                     0              0.000000 #> GZMB                         0                     0              1.083301 #> TSC2                         0                     0              0.000000 #>          X56_Y-97..Endothelial X75_Y-98..Endothelial X78_Y-98..Endothelial #> PDK4                 1.6027300                     0             0.6707283 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.3625463                     0             0.4975883 #> GZMB                 0.4814671                     0             0.0000000 #> TSC2                 0.0000000                     0             0.0000000 #>          X78_Y-99..Endothelial X78_Y-100..Endothelial X76_Y-100..Endothelial #> PDK4                 1.2232721                1.07779                      0 #> TNFRSF17             0.0000000                0.00000                      0 #> ICAM3                0.0000000                0.00000                      0 #> FAP                  0.2296562                0.00000                      0 #> GZMB                 0.0000000                0.00000                      0 #> TSC2                 0.0000000                0.00000                      0 #>          X76_Y-101..Endothelial X73_Y-101..Endothelial X78_Y-101..Endothelial #> PDK4                  0.8234747                      0                      0 #> TNFRSF17              0.0000000                      0                      0 #> ICAM3                 0.0000000                      0                      0 #> FAP                   0.7564919                      0                      0 #> GZMB                  0.0000000                      0                      0 #> TSC2                  0.0000000                      0                      0 #>          X73_Y-102..Endothelial X76_Y-102..Endothelial X77_Y-102..Endothelial #> PDK4                  0.6289972              0.6436798              0.3263064 #> TNFRSF17              0.0000000              0.0000000              0.0000000 #> ICAM3                 0.0000000              0.0000000              0.0000000 #> FAP                   0.0000000              0.4908489              0.0000000 #> GZMB                  0.6289972              0.4403334              0.3453873 #> TSC2                  0.0000000              0.0000000              0.0000000 #>          X76_Y-103..Endothelial X79_Y-98..Endothelial X75_Y-103..Endothelial #> PDK4                  0.4006007             0.9383771              0.2338305 #> TNFRSF17              0.0000000             0.0000000              0.0000000 #> ICAM3                 0.0000000             0.0000000              0.0000000 #> FAP                   0.0000000             0.3731913              0.0000000 #> GZMB                  0.2029701             0.0000000              0.2410270 #> TSC2                  0.0000000             0.0000000              0.0000000 #>          X75_Y-104..Endothelial X75_Y-85..Endothelial X75_Y-86..Endothelial #> PDK4                  0.0000000              1.040855              1.040855 #> TNFRSF17              0.0000000              0.000000              0.000000 #> ICAM3                 0.0000000              0.000000              0.000000 #> FAP                   0.0000000              0.000000              0.000000 #> GZMB                  0.7534725              0.000000              0.000000 #> TSC2                  0.0000000              0.000000              0.000000 #>          X78_Y-87..Endothelial X76_Y-87..Endothelial X77_Y-87..Endothelial #> PDK4                  3.694257             1.5516406             1.2929232 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   3.694257             0.4222984             0.4645283 #> GZMB                  0.000000             0.3790611             0.4169673 #> TSC2                  0.000000             0.4222984             0.4645283 #>          X78_Y-91..Endothelial X77_Y-91..Endothelial X78_Y-85..Endothelial #> PDK4                 0.9663610             0.9663610              1.123547 #> TNFRSF17             0.0000000             0.0000000              0.000000 #> ICAM3                0.0000000             0.0000000              0.000000 #> FAP                  0.0000000             0.0000000              0.000000 #> GZMB                 0.3439382             0.3439382              0.000000 #> TSC2                 0.0000000             0.0000000              0.000000 #>          X73_Y-85..Endothelial X33_Y-73..Endothelial X31_Y-73..Endothelial #> PDK4                         0             1.0687675              1.255199 #> TNFRSF17                     0             0.0000000              0.000000 #> ICAM3                        0             0.0000000              0.000000 #> FAP                          0             0.2442264              0.000000 #> GZMB                         0             0.0000000              0.000000 #> TSC2                         0             0.3278334              0.000000 #>          X32_Y-74..Endothelial X31_Y-74..Endothelial X35_Y-77..Endothelial #> PDK4                 0.9806495             0.5090745              1.644347 #> TNFRSF17             0.0000000             0.0000000              0.000000 #> ICAM3                0.0000000             0.0000000              0.000000 #> FAP                  0.0000000             0.0000000              0.000000 #> GZMB                 0.0000000             0.0000000              0.000000 #> TSC2                 0.0000000             0.0000000              0.000000 #>          X35_Y-78..Endothelial X30_Y-78..Endothelial X36_Y-79..Endothelial #> PDK4                 0.7870859             0.7042003             0.8540386 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.3341206             0.0000000             0.5042380 #> GZMB                 0.0000000             0.0000000             0.5305103 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X31_Y-72..Endothelial X30_Y-72..Endothelial X33_Y-72..Endothelial #> PDK4                 0.3996139             0.8063748             0.7926146 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.0000000             0.0000000 #> GZMB                 0.2521216             0.2653912             0.0000000 #> TSC2                 0.0000000             0.1779634             0.3278334 #>          X32_Y-73..Endothelial X30_Y-73..Endothelial X30_Y-74..Endothelial #> PDK4                 0.7119730             1.2930691             0.6941926 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.3256353             0.0000000             0.0000000 #> GZMB                 0.3404694             0.0000000             0.0000000 #> TSC2                 0.3221282             0.3757004             0.0000000 #>          X34_Y-78..Endothelial X30_Y-79..Endothelial X35_Y-79..Endothelial #> PDK4                 0.9681625              1.638518             0.8595992 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.4594158              0.000000             1.0015582 #> GZMB                 0.0000000              0.000000             0.0000000 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X37_Y-67..Endothelial X42_Y-67..Endothelial X41_Y-68..Endothelial #> PDK4                         0               1.43662             0.3956705 #> TNFRSF17                     0               0.00000             0.0000000 #> ICAM3                        0               0.00000             0.0000000 #> FAP                          0               0.00000             0.6531360 #> GZMB                         0               0.00000             0.0000000 #> TSC2                         0               0.00000             0.0000000 #>          X35_Y-68..Endothelial X41_Y-69..Endothelial X39_Y-69..Endothelial #> PDK4                  0.000000             1.1325629             0.9541226 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   1.720393             0.8476295             0.9541226 #> GZMB                  0.000000             0.0000000             0.0000000 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X40_Y-69..Endothelial X35_Y-69..Endothelial X38_Y-71..Endothelial #> PDK4                  1.510084                     0             0.0000000 #> TNFRSF17              0.000000                     0             0.0000000 #> ICAM3                 0.000000                     0             0.0000000 #> FAP                   0.499083                     0             0.0000000 #> GZMB                  0.000000                     0             0.2945862 #> TSC2                  0.000000                     0             0.0000000 #>          X39_Y-71..Endothelial X40_Y-71..Endothelial X40_Y-72..Endothelial #> PDK4                  0.000000              1.015642              1.304263 #> TNFRSF17              0.000000              0.000000              0.000000 #> ICAM3                 0.000000              0.000000              0.000000 #> FAP                   0.000000              0.000000              0.000000 #> GZMB                  0.382962              0.000000              0.000000 #> TSC2                  0.000000              0.000000              0.000000 #>          X38_Y-72..Endothelial X39_Y-73..Endothelial X40_Y-73..Endothelial #> PDK4                 0.1363459             0.8916219             0.5922064 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.1509120             0.4192954             0.0000000 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X41_Y-67..Endothelial X42_Y-68..Endothelial X39_Y-70..Endothelial #> PDK4                  1.374147             0.8025693               0.00000 #> TNFRSF17              0.000000             0.0000000               0.00000 #> ICAM3                 0.000000             0.0000000               0.00000 #> FAP                   0.000000             0.0000000               0.00000 #> GZMB                  0.000000             0.0000000               0.63827 #> TSC2                  0.000000             0.0000000               0.00000 #>          X39_Y-72..Endothelial X38_Y-73..Endothelial X37_Y-73..Endothelial #> PDK4                  0.989385             1.6258524             1.2512386 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             0.3589168             0.4277305 #> GZMB                  0.000000             0.0000000             0.3388970 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X37_Y-74..Endothelial X38_Y-74..Endothelial X39_Y-74..Endothelial #> PDK4                 0.6996443             0.9270162             2.8871844 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.2592460             0.6945588             0.8241521 #> GZMB                 0.4518627             0.5213800             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X41_Y-75..Endothelial X38_Y-75..Endothelial X40_Y-75..Endothelial #> PDK4                 0.5918616              1.736219             0.7498636 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.7381426              1.785285             0.3700352 #> GZMB                 0.0000000              0.000000             0.0000000 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X39_Y-75..Endothelial X37_Y-75..Endothelial X38_Y-76..Endothelial #> PDK4                 1.4838463             0.8694723             0.2206591 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.2735358             0.1803323             0.4764148 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X37_Y-76..Endothelial X39_Y-76..Endothelial X42_Y-77..Endothelial #> PDK4                 0.4986333              1.237822             1.2620858 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.1868640              0.000000             0.6658778 #> GZMB                 0.0000000              0.000000             0.0000000 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X37_Y-77..Endothelial X41_Y-78..Endothelial X42_Y-78..Endothelial #> PDK4                 0.5480896              0.000000             1.6506942 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.3453042              4.686998             0.0000000 #> GZMB                 0.0000000              0.000000             0.2330819 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X38_Y-78..Endothelial X40_Y-78..Endothelial X36_Y-78..Endothelial #> PDK4                 0.4360977              1.641654             0.0000000 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.0000000              0.000000             0.7102070 #> GZMB                 0.0000000              0.000000             0.3713572 #> TSC2                 0.0000000              0.000000             0.4520800 #>          X39_Y-78..Endothelial X37_Y-78..Endothelial X79_Y-78..Endothelial #> PDK4                 2.0915196              1.812714                     0 #> TNFRSF17             0.0000000              0.000000                     0 #> ICAM3                0.0000000              0.000000                     0 #> FAP                  0.3912929              1.616597                     0 #> GZMB                 0.0000000              0.000000                     0 #> TSC2                 0.0000000              0.000000                     0 #>          X75_Y-73..Endothelial X76_Y-73..Endothelial X73_Y-73..Endothelial #> PDK4                 0.4126319                     0              1.416312 #> TNFRSF17             0.0000000                     0              0.000000 #> ICAM3                0.0000000                     0              0.000000 #> FAP                  0.0000000                     0              0.000000 #> GZMB                 0.0000000                     0              0.000000 #> TSC2                 0.0000000                     0              0.000000 #>          X75_Y-74..Endothelial X76_Y-74..Endothelial X73_Y-74..Endothelial #> PDK4                  1.209938                     0              2.127412 #> TNFRSF17              0.000000                     0              0.000000 #> ICAM3                 0.000000                     0              0.000000 #> FAP                   0.000000                     0              0.000000 #> GZMB                  0.000000                     0              0.000000 #> TSC2                  0.000000                     0              0.000000 #>          X75_Y-75..Endothelial X74_Y-75..Endothelial X76_Y-75..Endothelial #> PDK4                  1.561007             0.4749075              0.000000 #> TNFRSF17              0.000000             0.0000000              0.000000 #> ICAM3                 0.000000             0.0000000              0.000000 #> FAP                   1.211063             0.5768901              0.000000 #> GZMB                  0.000000             0.4939545              0.000000 #> TSC2                  0.000000             0.0000000              2.066379 #>          X78_Y-75..Endothelial X78_Y-76..Endothelial X75_Y-76..Endothelial #> PDK4                 0.9999217             0.4444671             1.6608412 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.0000000             0.6359124 #> GZMB                 1.1016603             0.9639527             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X74_Y-76..Endothelial X73_Y-76..Endothelial X75_Y-77..Endothelial #> PDK4                 1.0719422              1.127529                     0 #> TNFRSF17             0.0000000              0.000000                     0 #> ICAM3                0.0000000              0.000000                     0 #> FAP                  0.3868022              0.000000                     0 #> GZMB                 0.3592396              0.000000                     0 #> TSC2                 0.0000000              0.000000                     0 #>          X73_Y-77..Endothelial X78_Y-77..Endothelial X73_Y-78..Endothelial #> PDK4                  1.002248               2.61249             0.7358347 #> TNFRSF17              0.000000               0.00000             0.0000000 #> ICAM3                 0.000000               0.00000             0.0000000 #> FAP                   0.000000               0.00000             0.3862604 #> GZMB                  0.000000               0.00000             0.0000000 #> TSC2                  0.000000               0.00000             0.0000000 #>          X77_Y-78..Endothelial X78_Y-78..Endothelial X76_Y-79..Endothelial #> PDK4                  0.000000             0.0000000             1.6191279 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             0.0000000             0.6363983 #> GZMB                  0.585096             0.8352553             0.0000000 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X78_Y-79..Endothelial X76_Y-72..Endothelial X73_Y-72..Endothelial #> PDK4                  1.120763             0.7995658             0.6742129 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             0.0000000             0.6266542 #> GZMB                  0.000000             0.0000000             0.0000000 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X77_Y-73..Endothelial X65_Y-70..Endothelial X62_Y-70..Endothelial #> PDK4                         0             0.8097657                     0 #> TNFRSF17                     0             0.0000000                     0 #> ICAM3                        0             0.0000000                     0 #> FAP                          0             0.0000000                     0 #> GZMB                         0             1.0759916                     0 #> TSC2                         0             0.0000000                     0 #>          X63_Y-70..Endothelial X64_Y-70..Endothelial X61_Y-70..Endothelial #> PDK4                         0              1.760947             0.7523182 #> TNFRSF17                     0              0.000000             0.0000000 #> ICAM3                        0              0.000000             0.0000000 #> FAP                          0              0.000000             0.7335717 #> GZMB                         0              0.661493             0.0000000 #> TSC2                         0              0.000000             0.0000000 #>          X62_Y-71..Endothelial X63_Y-71..Endothelial X65_Y-71..Endothelial #> PDK4                         0             0.8206074              1.034704 #> TNFRSF17                     0             0.0000000              0.000000 #> ICAM3                        0             0.0000000              0.000000 #> FAP                          0             0.0000000              0.000000 #> GZMB                         0             0.0000000              1.075992 #> TSC2                         0             0.0000000              0.000000 #>          X64_Y-72..Endothelial X65_Y-72..Endothelial X62_Y-73..Endothelial #> PDK4                         0                     0                     0 #> TNFRSF17                     0                     0                     0 #> ICAM3                        0                     0                     0 #> FAP                          0                     0                     0 #> GZMB                         0                     0                     0 #> TSC2                         0                     0                     0 #>          X63_Y-74..Endothelial X67_Y-74..Endothelial X65_Y-75..Endothelial #> PDK4                         0                     0             1.2223834 #> TNFRSF17                     0                     0             0.0000000 #> ICAM3                        0                     0             0.0000000 #> FAP                          0                     0             0.4637097 #> GZMB                         0                     0             0.0000000 #> TSC2                         0                     0             0.4163208 #>          X66_Y-76..Endothelial X66_Y-77..Endothelial X67_Y-77..Endothelial #> PDK4                 0.3378579             1.0417412             0.6864135 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.8587407             0.2511868             0.6154713 #> GZMB                 0.4465543             0.4927830             0.6065021 #> TSC2                 0.3700630             0.1595077             0.0000000 #>          X63_Y-73..Endothelial X66_Y-73..Endothelial X65_Y-74..Endothelial #> PDK4                         0                     0              1.985932 #> TNFRSF17                     0                     0              0.000000 #> ICAM3                        0                     0              0.000000 #> FAP                          0                     0              0.000000 #> GZMB                         0                     0              1.985932 #> TSC2                         0                     0              0.000000 #>          X64_Y-74..Endothelial X65_Y-76..Endothelial X64_Y-76..Endothelial #> PDK4                  2.663617             1.2223834              0.000000 #> TNFRSF17              0.000000             0.0000000              0.000000 #> ICAM3                 0.000000             0.0000000              0.000000 #> FAP                   0.000000             0.4637097              0.000000 #> GZMB                  1.323954             0.0000000              0.000000 #> TSC2                  0.000000             0.4163208              4.318475 #>          X72_Y-73..Endothelial X69_Y-75..Endothelial X69_Y-76..Endothelial #> PDK4                   3.94168             0.0000000             0.4159964 #> TNFRSF17               0.00000             0.0000000             0.0000000 #> ICAM3                  0.00000             0.0000000             0.0000000 #> FAP                    0.00000             0.4803665             0.0000000 #> GZMB                   0.00000             0.0000000             0.0000000 #> TSC2                   0.00000             0.0000000             0.0000000 #>          X68_Y-76..Endothelial X70_Y-76..Endothelial X72_Y-76..Endothelial #> PDK4                  2.006819                     0              2.317191 #> TNFRSF17              0.000000                     0              0.000000 #> ICAM3                 0.000000                     0              0.000000 #> FAP                   0.000000                     0              0.000000 #> GZMB                  0.000000                     0              0.000000 #> TSC2                  0.000000                     0              0.000000 #>          X72_Y-77..Endothelial X71_Y-77..Endothelial X70_Y-77..Endothelial #> PDK4                 0.4099985             0.4447803                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.0000000             0.0000000                     0 #> GZMB                 0.0000000             0.0000000                     0 #> TSC2                 0.0000000             0.0000000                     0 #>          X70_Y-78..Endothelial X71_Y-78..Endothelial X73_Y-79..Endothelial #> PDK4                  2.006819                     0              1.103752 #> TNFRSF17              0.000000                     0              0.000000 #> ICAM3                 0.000000                     0              0.000000 #> FAP                   0.000000                     0              0.000000 #> GZMB                  0.000000                     0              0.000000 #> TSC2                  0.000000                     0              0.000000 #>          X70_Y-79..Endothelial X71_Y-79..Endothelial X72_Y-74..Endothelial #> PDK4                 1.1986874              1.398362              2.732168 #> TNFRSF17             0.0000000              0.000000              0.000000 #> ICAM3                0.0000000              0.000000              0.000000 #> FAP                  0.0000000              0.000000              0.000000 #> GZMB                 0.4355722              0.000000              0.000000 #> TSC2                 0.0000000              0.000000              0.000000 #>          X71_Y-74..Endothelial X58_Y-73..Endothelial X57_Y-73..Endothelial #> PDK4                         0             0.8496557             0.8119029 #> TNFRSF17                     0             0.0000000             0.0000000 #> ICAM3                        0             0.0000000             0.0000000 #> FAP                          0             0.4233368             0.2877191 #> GZMB                         0             0.1476121             0.3112437 #> TSC2                         0             0.0000000             0.1333782 #>          X57_Y-74..Endothelial X59_Y-75..Endothelial X60_Y-75..Endothelial #> PDK4                 0.4884197             0.5071364             0.5071364 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.2300295             0.2487942             0.2487942 #> GZMB                 0.2337595             0.0000000             0.0000000 #> TSC2                 0.4205697             0.0000000             0.0000000 #>          X58_Y-75..Endothelial X59_Y-76..Endothelial X58_Y-76..Endothelial #> PDK4                 0.6273057             0.9562942             0.3568031 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.0000000             0.0000000 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X54_Y-77..Endothelial X54_Y-78..Endothelial X55_Y-78..Endothelial #> PDK4                 0.6566938             0.8621751             0.3444224 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.3902681             0.4601614             1.1201001 #> GZMB                 0.2821430             0.4798245             0.8724082 #> TSC2                 0.2915969             0.1895380             0.0000000 #>          X55_Y-79..Endothelial X54_Y-79..Endothelial X58_Y-74..Endothelial #> PDK4                 1.0141077             0.4463157             0.5061955 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.2332959             0.3955178 #> GZMB                 0.5196002             0.2338201             0.0000000 #> TSC2                 0.0000000             0.2343499             0.3925318 #>          X68_Y-66..Endothelial X68_Y-67..Endothelial X68_Y-68..Endothelial #> PDK4                         0             0.6030263              0.527648 #> TNFRSF17                     0             0.0000000              0.000000 #> ICAM3                        0             0.0000000              0.000000 #> FAP                          0             0.0000000              0.000000 #> GZMB                         0             0.0000000              0.000000 #> TSC2                         0             0.0000000              0.000000 #>          X73_Y-68..Endothelial X71_Y-68..Endothelial X69_Y-68..Endothelial #> PDK4                  1.132458             0.9364599             0.8442368 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             0.0000000             0.0000000 #> GZMB                  0.000000             0.0000000             0.0000000 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X72_Y-68..Endothelial X68_Y-69..Endothelial X71_Y-69..Endothelial #> PDK4                  2.497226             0.7052915             0.7530552 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             0.0000000             0.2296562 #> GZMB                  0.000000             0.0000000             0.2715128 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X72_Y-69..Endothelial X68_Y-70..Endothelial X69_Y-70..Endothelial #> PDK4                 0.8158098              1.175486             2.6496611 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.2487942              1.332586             0.4049601 #> GZMB                 0.2941389              0.000000             0.0000000 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X70_Y-70..Endothelial X69_Y-71..Endothelial X70_Y-71..Endothelial #> PDK4                 2.5769900             2.6496611             2.5769900 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.3149689             0.4049601             0.3149689 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X67_Y-71..Endothelial X68_Y-72..Endothelial X73_Y-66..Endothelial #> PDK4                  0.000000                     0             0.4002166 #> TNFRSF17              0.000000                     0             0.0000000 #> ICAM3                 0.000000                     0             0.0000000 #> FAP                   1.329106                     0             0.4290446 #> GZMB                  0.000000                     0             0.0000000 #> TSC2                  0.000000                     0             0.3994954 #>          X73_Y-67..Endothelial X69_Y-72..Endothelial X54_Y-72..Endothelial #> PDK4                 0.9668519                     0                     0 #> TNFRSF17             0.0000000                     0                     0 #> ICAM3                0.0000000                     0                     0 #> FAP                  0.4719490                     0                     0 #> GZMB                 0.0000000                     0                     0 #> TSC2                 0.0000000                     0                     0 #>          X52_Y-73..Endothelial X51_Y-73..Endothelial X49_Y-73..Endothelial #> PDK4                  0.000000             0.8651222              4.182296 #> TNFRSF17              0.000000             0.0000000              0.000000 #> ICAM3                 0.000000             0.0000000              0.000000 #> FAP                   1.152782             0.5669179              0.000000 #> GZMB                  0.594137             0.5947178              0.000000 #> TSC2                  0.000000             0.0000000              0.000000 #>          X50_Y-73..Endothelial X50_Y-74..Endothelial X53_Y-74..Endothelial #> PDK4                  1.640278              0.608304                     0 #> TNFRSF17              0.000000              0.000000                     0 #> ICAM3                 0.000000              0.000000                     0 #> FAP                   0.000000              0.000000                     0 #> GZMB                  0.000000              0.000000                     0 #> TSC2                  0.000000              0.000000                     0 #>          X52_Y-74..Endothelial X51_Y-74..Endothelial X53_Y-75..Endothelial #> PDK4                 0.0000000             1.2722463             1.2019316 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.0000000             0.5921297 #> GZMB                 0.8853154             0.3457069             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X54_Y-75..Endothelial X53_Y-76..Endothelial X48_Y-77..Endothelial #> PDK4                 1.6796437             1.5298431                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.5181135             0.5181135                     0 #> GZMB                 0.0000000             0.4584823                     0 #> TSC2                 0.3718606             0.0000000                     0 #>          X53_Y-78..Endothelial X51_Y-78..Endothelial X52_Y-78..Endothelial #> PDK4                  1.672713             0.4728577             0.4728577 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             0.4728577             0.4728577 #> GZMB                  0.000000             0.4728577             0.4728577 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X54_Y-76..Endothelial X49_Y-79..Endothelial X50_Y-79..Endothelial #> PDK4                 0.0000000              1.090686                     0 #> TNFRSF17             0.0000000              0.000000                     0 #> ICAM3                0.0000000              0.000000                     0 #> FAP                  0.8455810              0.000000                     0 #> GZMB                 0.6113098              0.000000                     0 #> TSC2                 0.0000000              0.000000                     0 #>          X44_Y-91..Endothelial X43_Y-91..Endothelial X47_Y-92..Endothelial #> PDK4                 0.0000000              0.949815             0.6197871 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.5486861              0.000000             0.0000000 #> GZMB                 0.0000000              0.000000             0.0000000 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X44_Y-92..Endothelial X46_Y-92..Endothelial X42_Y-93..Endothelial #> PDK4                 0.2902074             0.4426577             0.7431380 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.5855210             0.0000000             0.7480543 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X43_Y-93..Endothelial X42_Y-94..Endothelial X43_Y-94..Endothelial #> PDK4                  0.000000             0.5812126             0.3539842 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   1.047037             0.4079932             0.7720089 #> GZMB                  0.000000             0.0000000             0.0000000 #> TSC2                  0.000000             0.2120614             0.0000000 #>          X46_Y-94..Endothelial X43_Y-95..Endothelial X48_Y-95..Endothelial #> PDK4                         0             0.0000000              0.000000 #> TNFRSF17                     0             0.0000000              0.000000 #> ICAM3                        0             0.0000000              0.000000 #> FAP                          0             0.9629777              0.000000 #> GZMB                         0             0.0000000              1.260778 #> TSC2                         0             0.0000000              0.000000 #>          X41_Y-95..Endothelial X43_Y-96..Endothelial X45_Y-96..Endothelial #> PDK4                  2.009691             0.2684563             0.1985126 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             0.7593920             0.0000000 #> GZMB                  0.000000             0.0000000             0.2407422 #> TSC2                  0.000000             0.2278723             0.0000000 #>          X42_Y-96..Endothelial X44_Y-96..Endothelial X45_Y-97..Endothelial #> PDK4                 0.9355264             0.0000000             0.2779176 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.8243603             0.4517058             0.0000000 #> GZMB                 0.0000000             0.0000000             0.3370391 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X47_Y-96..Endothelial X43_Y-97..Endothelial X46_Y-97..Endothelial #> PDK4                         0             0.5849136             0.6232818 #> TNFRSF17                     0             0.0000000             0.0000000 #> ICAM3                        0             0.0000000             0.0000000 #> FAP                          0             0.5567975             0.0000000 #> GZMB                         0             0.0000000             0.0000000 #> TSC2                         0             0.1841427             0.0000000 #>          X47_Y-97..Endothelial X42_Y-97..Endothelial X45_Y-91..Endothelial #> PDK4                   0.34496             0.2271161             0.0000000 #> TNFRSF17               0.00000             0.0000000             0.0000000 #> ICAM3                  0.00000             0.0000000             0.0000000 #> FAP                    0.00000             0.8584231             0.7105898 #> GZMB                   0.00000             0.2562189             0.0000000 #> TSC2                   0.00000             0.2166384             0.0000000 #>          X45_Y-92..Endothelial X42_Y-95..Endothelial X44_Y-97..Endothelial #> PDK4                         0             1.1825303             0.7549723 #> TNFRSF17                     0             0.0000000             0.0000000 #> ICAM3                        0             0.0000000             0.0000000 #> FAP                          0             0.7240133             0.0000000 #> GZMB                         0             0.0000000             0.0000000 #> TSC2                         0             0.0000000             0.0000000 #>          X43_Y-98..Endothelial X23_Y-77..Endothelial X22_Y-77..Endothelial #> PDK4                 0.0000000              1.256729              4.382669 #> TNFRSF17             0.0000000              0.000000              0.000000 #> ICAM3                0.0000000              0.000000              0.000000 #> FAP                  0.2590567              0.000000              0.000000 #> GZMB                 0.0000000              0.000000              0.000000 #> TSC2                 0.0000000              0.000000              0.000000 #>          X24_Y-78..Endothelial X23_Y-78..Endothelial X22_Y-78..Endothelial #> PDK4                 0.8384455              1.340511              1.436262 #> TNFRSF17             0.0000000              0.000000              0.000000 #> ICAM3                0.0000000              0.000000              0.000000 #> FAP                  0.6547753              0.000000              0.000000 #> GZMB                 0.2922508              0.000000              0.000000 #> TSC2                 0.0000000              0.000000              0.000000 #>          X22_Y-79..Endothelial X24_Y-77..Endothelial X25_Y-73..Endothelial #> PDK4                 1.6453959             0.3574726             2.1650842 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.3598729             0.6296916 #> GZMB                 0.3115812             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X26_Y-73..Endothelial X25_Y-74..Endothelial X24_Y-74..Endothelial #> PDK4                  1.231234              1.175907              0.000000 #> TNFRSF17              0.000000              0.000000              0.000000 #> ICAM3                 0.000000              0.000000              0.000000 #> FAP                   0.000000              0.000000              0.000000 #> GZMB                  0.000000              0.000000              0.000000 #> TSC2                  0.000000              0.000000              0.723442 #>          X24_Y-75..Endothelial X25_Y-75..Endothelial X25_Y-76..Endothelial #> PDK4                 0.7564919             0.9077902              1.062157 #> TNFRSF17             0.0000000             0.0000000              0.000000 #> ICAM3                0.0000000             0.0000000              0.000000 #> FAP                  0.0000000             0.0000000              0.000000 #> GZMB                 0.0000000             0.0000000              0.000000 #> TSC2                 0.7234420             0.8681304              0.000000 #>          X25_Y-77..Endothelial X26_Y-72..Endothelial X29_Y-72..Endothelial #> PDK4                 0.3574726              1.153207              2.810484 #> TNFRSF17             0.0000000              0.000000              0.000000 #> ICAM3                0.0000000              0.000000              0.000000 #> FAP                  0.3598729              0.000000              1.168099 #> GZMB                 0.0000000              0.000000              0.000000 #> TSC2                 0.0000000              0.000000              0.000000 #>          X24_Y-72..Endothelial X24_Y-73..Endothelial X26_Y-76..Endothelial #> PDK4                   1.87629             2.1449660                     0 #> TNFRSF17               0.00000             0.0000000                     0 #> ICAM3                  0.00000             0.0000000                     0 #> FAP                    0.00000             0.4722687                     0 #> GZMB                   0.00000             0.0000000                     0 #> TSC2                   0.00000             0.0000000                     0 #>          X25_Y-78..Endothelial X25_Y-79..Endothelial X24_Y-79..Endothelial #> PDK4                 0.5344367             1.0725816             0.9347402 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.6080056             0.2716813             0.3169616 #> GZMB                 0.2713757             0.2713757             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X26_Y-79..Endothelial X34_Y-67..Endothelial X30_Y-70..Endothelial #> PDK4                         0                     0                     0 #> TNFRSF17                     0                     0                     0 #> ICAM3                        0                     0                     0 #> FAP                          0                     0                     0 #> GZMB                         0                     0                     0 #> TSC2                         0                     0                     0 #>          X33_Y-70..Endothelial X35_Y-70..Endothelial X34_Y-70..Endothelial #> PDK4                  0.000000             1.2894122              1.031530 #> TNFRSF17              0.000000             0.0000000              0.000000 #> ICAM3                 0.000000             0.0000000              0.000000 #> FAP                   0.000000             0.0000000              0.000000 #> GZMB                  0.000000             0.4872638              0.389811 #> TSC2                  2.411979             0.0000000              0.000000 #>          X34_Y-71..Endothelial X32_Y-72..Endothelial X33_Y-67..Endothelial #> PDK4                 0.7607077              0.514738              4.311194 #> TNFRSF17             0.0000000              0.000000              0.000000 #> ICAM3                0.0000000              0.000000              0.000000 #> FAP                  0.0000000              0.000000              0.000000 #> GZMB                 0.7796220              0.000000              0.000000 #> TSC2                 0.0000000              0.000000              0.000000 #>          X30_Y-68..Endothelial X31_Y-70..Endothelial X31_Y-71..Endothelial #> PDK4                  2.549573              4.333887             0.6652454 #> TNFRSF17              0.000000              0.000000             0.0000000 #> ICAM3                 0.000000              0.000000             0.0000000 #> FAP                   0.000000              0.000000             0.0000000 #> GZMB                  0.000000              0.000000             0.2801351 #> TSC2                  0.000000              0.000000             0.0000000 #>          X33_Y-71..Endothelial X30_Y-71..Endothelial X33_Y-65..Endothelial #> PDK4                 0.0000000             0.5916781              3.464477 #> TNFRSF17             0.0000000             0.0000000              0.000000 #> ICAM3                0.0000000             0.0000000              0.000000 #> FAP                  0.8523389             0.0000000              0.000000 #> GZMB                 0.0000000             0.0000000              0.000000 #> TSC2                 0.0000000             0.0000000              0.000000 #>          X36_Y-80..Endothelial X30_Y-80..Endothelial X35_Y-80..Endothelial #> PDK4                 0.6195601              2.018057             2.0764464 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.0000000              0.000000             0.3081741 #> GZMB                 0.0000000              0.000000             0.0000000 #> TSC2                 0.0000000              0.000000             0.3041201 #>          X35_Y-81..Endothelial X36_Y-81..Endothelial X34_Y-81..Endothelial #> PDK4                 1.1151915             0.3862895             0.9235643 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.4426129             0.0000000 #> GZMB                 0.2113077             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X35_Y-82..Endothelial X34_Y-82..Endothelial X35_Y-83..Endothelial #> PDK4                 0.5819524              1.661536             0.4766301 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.0000000              0.000000             0.0000000 #> GZMB                 0.1828383              0.000000             0.0000000 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X36_Y-83..Endothelial X30_Y-84..Endothelial X30_Y-85..Endothelial #> PDK4                 0.8388638               1.20701             0.5450324 #> TNFRSF17             0.0000000               0.00000             0.0000000 #> ICAM3                0.0000000               0.00000             0.0000000 #> FAP                  0.2175929               0.00000             0.0000000 #> GZMB                 0.0000000               0.00000             0.0000000 #> TSC2                 0.0000000               0.00000             0.0000000 #>          X31_Y-85..Endothelial X33_Y-81..Endothelial X36_Y-82..Endothelial #> PDK4                 0.9353892                     0             0.3561442 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.0000000                     0             0.2048600 #> GZMB                 0.0000000                     0             0.1828383 #> TSC2                 0.0000000                     0             0.0000000 #>          X34_Y-83..Endothelial X34_Y-84..Endothelial X29_Y-84..Endothelial #> PDK4                 0.8914254             0.8914254              1.295232 #> TNFRSF17             0.0000000             0.0000000              0.000000 #> ICAM3                0.0000000             0.0000000              0.000000 #> FAP                  0.0000000             0.0000000              0.000000 #> GZMB                 0.0000000             0.0000000              0.000000 #> TSC2                 0.8914254             0.8914254              0.000000 #>          X32_Y-85..Endothelial X38_Y-64..Endothelial X38_Y-65..Endothelial #> PDK4                         0              3.914820                     0 #> TNFRSF17                     0              0.000000                     0 #> ICAM3                        0              0.000000                     0 #> FAP                          0              3.241421                     0 #> GZMB                         0              0.000000                     0 #> TSC2                         0              0.000000                     0 #>          X38_Y-66..Endothelial X36_Y-66..Endothelial X42_Y-66..Endothelial #> PDK4                         0              1.573619              1.389913 #> TNFRSF17                     0              0.000000              0.000000 #> ICAM3                        0              0.000000              0.000000 #> FAP                          0              0.000000              0.000000 #> GZMB                         0              0.000000              0.000000 #> TSC2                         0              0.000000              0.000000 #>          X23_Y-67..Endothelial X24_Y-67..Endothelial X22_Y-68..Endothelial #> PDK4                  1.164795             0.9416899             2.2356393 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             0.2006819             0.0000000 #> GZMB                  0.000000             0.2057408             0.0000000 #> TSC2                  0.000000             0.0000000             0.1687916 #>          X23_Y-68..Endothelial X21_Y-68..Endothelial X22_Y-69..Endothelial #> PDK4                   2.01414             1.9832642             2.4821051 #> TNFRSF17               0.00000             0.0000000             0.0000000 #> ICAM3                  0.00000             0.0000000             0.0000000 #> FAP                    0.00000             0.0000000             0.0000000 #> GZMB                   0.00000             0.0000000             0.0000000 #> TSC2                   0.00000             0.4219789             0.1875462 #>          X23_Y-69..Endothelial X22_Y-72..Endothelial X29_Y-80..Endothelial #> PDK4                  1.974855             0.9796744                     0 #> TNFRSF17              0.000000             0.0000000                     0 #> ICAM3                 0.000000             0.0000000                     0 #> FAP                   0.000000             0.0000000                     0 #> GZMB                  0.000000             0.0000000                     0 #> TSC2                  0.000000             0.0000000                     0 #>          X25_Y-81..Endothelial X26_Y-81..Endothelial X26_Y-82..Endothelial #> PDK4                  4.635125             0.8159799             0.0000000 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             1.0416984             0.7440703 #> GZMB                  0.000000             0.0000000             0.0000000 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X23_Y-82..Endothelial X28_Y-82..Endothelial X27_Y-82..Endothelial #> PDK4                 0.0000000             0.0000000             0.8543770 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.6516754             0.6034497             0.7902847 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.7447139             0.4964759 #>          X28_Y-83..Endothelial X27_Y-83..Endothelial X28_Y-84..Endothelial #> PDK4                 0.8607599             1.2815655             0.4379644 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.3620698             0.5819774             0.0000000 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.4468283             0.0000000             0.0000000 #>          X26_Y-84..Endothelial X26_Y-85..Endothelial X23_Y-79..Endothelial #> PDK4                  0.984185             0.9664662             1.0262621 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.957405             0.0000000             0.0000000 #> GZMB                  0.000000             0.0000000             0.6363843 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X24_Y-80..Endothelial X23_Y-81..Endothelial X24_Y-81..Endothelial #> PDK4                 0.6928685             0.2359745                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.0000000             0.0000000                     0 #> GZMB                 0.0000000             0.2009494                     0 #> TSC2                 0.0000000             0.2359745                     0 #>          X26_Y-83..Endothelial X24_Y-83..Endothelial X24_Y-84..Endothelial #> PDK4                  0.984185                     0                     0 #> TNFRSF17              0.000000                     0                     0 #> ICAM3                 0.000000                     0                     0 #> FAP                   0.957405                     0                     0 #> GZMB                  0.000000                     0                     0 #> TSC2                  0.000000                     0                     0 #>          X28_Y-85..Endothelial X29_Y-85..Endothelial X25_Y-66..Endothelial #> PDK4                  1.446364              1.285657             1.1652032 #> TNFRSF17              0.000000              0.000000             0.0000000 #> ICAM3                 0.000000              0.000000             0.0000000 #> FAP                   0.000000              0.000000             0.0000000 #> GZMB                  0.000000              0.000000             0.5549608 #> TSC2                  0.000000              0.000000             0.0000000 #>          X24_Y-66..Endothelial X25_Y-67..Endothelial X28_Y-67..Endothelial #> PDK4                 1.1119622             1.1119622              1.544472 #> TNFRSF17             0.0000000             0.0000000              0.000000 #> ICAM3                0.0000000             0.0000000              0.000000 #> FAP                  0.0000000             0.0000000              0.000000 #> GZMB                 0.5549608             0.5549608              0.000000 #> TSC2                 0.0000000             0.0000000              0.000000 #>          X27_Y-67..Endothelial X25_Y-68..Endothelial X26_Y-68..Endothelial #> PDK4                 0.9464191              1.813065             1.0882531 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.0000000              0.000000             0.0000000 #> GZMB                 0.0000000              0.000000             0.1583313 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X29_Y-68..Endothelial X28_Y-68..Endothelial X27_Y-68..Endothelial #> PDK4                 1.6343346                     0              1.318438 #> TNFRSF17             0.0000000                     0              0.000000 #> ICAM3                0.0000000                     0              0.000000 #> FAP                  0.0000000                     0              0.000000 #> GZMB                 0.4404075                     0              0.000000 #> TSC2                 0.0000000                     0              0.000000 #>          X25_Y-69..Endothelial X25_Y-70..Endothelial X26_Y-70..Endothelial #> PDK4                 0.4864134             0.4864134             0.9078801 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.0000000             0.3142794 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X29_Y-70..Endothelial X23_Y-71..Endothelial X29_Y-71..Endothelial #> PDK4                  1.791037              2.815324             1.5012954 #> TNFRSF17              0.000000              0.000000             0.0000000 #> ICAM3                 0.000000              0.000000             0.0000000 #> FAP                   0.000000              0.000000             0.0000000 #> GZMB                  1.132890              0.000000             0.7209299 #> TSC2                  0.000000              0.000000             0.0000000 #>          X26_Y-71..Endothelial X28_Y-71..Endothelial X28_Y-72..Endothelial #> PDK4                 0.9640177             0.7978866             0.7999609 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.2403313             0.0000000             0.0000000 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X25_Y-72..Endothelial X26_Y-67..Endothelial X22_Y-80..Endothelial #> PDK4                  1.520061             0.9131944             0.4491191 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             0.0000000             0.0000000 #> GZMB                  0.000000             0.1583313             0.0000000 #> TSC2                  0.000000             0.0000000             0.4399346 #>          X23_Y-80..Endothelial X22_Y-81..Endothelial X22_Y-82..Endothelial #> PDK4                 0.8004622             0.8762202             0.4812917 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.0000000             0.2145034 #> GZMB                 0.4520800             0.2009494             0.0000000 #> TSC2                 0.0000000             0.4460518             0.0000000 #>          X23_Y-83..Endothelial X22_Y-83..Endothelial X21_Y-83..Endothelial #> PDK4                         0             1.0521706             0.6813597 #> TNFRSF17                     0             0.0000000             0.0000000 #> ICAM3                        0             0.0000000             0.0000000 #> FAP                          0             0.5326333             0.3120049 #> GZMB                         0             0.0000000             0.0000000 #> TSC2                         0             0.0000000             0.0000000 #>          X23_Y-84..Endothelial X22_Y-84..Endothelial X21_Y-84..Endothelial #> PDK4                 0.0000000             0.2302635                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.4625072             0.2312536                     0 #> GZMB                 0.3941680             0.1970840                     0 #> TSC2                 0.0000000             0.0000000                     0 #>          X21_Y-85..Endothelial X22_Y-85..Endothelial X43_Y-64..Endothelial #> PDK4                 0.3248682             0.7456687             0.6975768 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.0000000             0.6550281 #> GZMB                 0.3248682             0.2526753             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X46_Y-64..Endothelial X44_Y-64..Endothelial X45_Y-64..Endothelial #> PDK4                 0.8668459                     0             0.2376547 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.4615634                     0             0.0000000 #> GZMB                 0.0000000                     0             0.1843320 #> TSC2                 0.0000000                     0             0.0000000 #>          X43_Y-65..Endothelial X46_Y-65..Endothelial X45_Y-65..Endothelial #> PDK4                 1.0375722             0.7324827             0.4625834 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.5954801             0.6006698             0.0000000 #> GZMB                 0.0000000             0.1341331             0.1843320 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X44_Y-65..Endothelial X48_Y-65..Endothelial X45_Y-66..Endothelial #> PDK4                 0.7480289              1.025056             0.9554066 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.0000000              0.884390             0.0000000 #> GZMB                 0.0000000              0.000000             0.0000000 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X46_Y-66..Endothelial X43_Y-66..Endothelial X48_Y-66..Endothelial #> PDK4                 0.7144360              1.283108             0.9111610 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.3868236              0.000000             0.7861244 #> GZMB                 0.1946694              0.000000             0.0000000 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X47_Y-66..Endothelial X46_Y-67..Endothelial X47_Y-67..Endothelial #> PDK4                 0.3754557             1.3212629             0.5833980 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.2065268             0.1808583             0.0000000 #> GZMB                 0.2737308             0.1946694             0.0000000 #> TSC2                 0.0000000             0.1455939             0.2370883 #>          X45_Y-67..Endothelial X52_Y-64..Endothelial X53_Y-64..Endothelial #> PDK4                 0.9955345             1.1374298             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.7234920             0.5245398             0.7868097 #> GZMB                 0.9929658             0.6296916             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X49_Y-64..Endothelial X52_Y-65..Endothelial X49_Y-65..Endothelial #> PDK4                 0.6432827             0.8530724                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.0000000             0.3934048                     0 #> GZMB                 0.0000000             0.4722687                     0 #> TSC2                 0.4181146             0.0000000                     0 #>          X54_Y-65..Endothelial X55_Y-65..Endothelial X53_Y-65..Endothelial #> PDK4                 0.5188800             1.1374856             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.4440548             0.3947154             0.6294477 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.4543701             0.4038845             0.0000000 #>          X51_Y-66..Endothelial X52_Y-66..Endothelial X52_Y-67..Endothelial #> PDK4                 0.7612854              0.752717             0.6021736 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.8421797              0.000000             0.0000000 #> GZMB                 0.0000000              0.000000             0.0000000 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X54_Y-67..Endothelial X39_Y-79..Endothelial X42_Y-79..Endothelial #> PDK4                 0.0000000             1.9588664              1.806109 #> TNFRSF17             0.0000000             0.0000000              0.000000 #> ICAM3                0.0000000             0.0000000              0.000000 #> FAP                  0.7815246             0.4471919              0.000000 #> GZMB                 0.0000000             0.0000000              0.000000 #> TSC2                 0.0000000             0.0000000              0.000000 #>          X37_Y-79..Endothelial X38_Y-79..Endothelial X37_Y-80..Endothelial #> PDK4                  2.569343                     0              1.534851 #> TNFRSF17              0.000000                     0              0.000000 #> ICAM3                 0.000000                     0              0.000000 #> FAP                   4.539500                     0              1.513167 #> GZMB                  0.000000                     0              0.000000 #> TSC2                  0.000000                     0              0.000000 #>          X42_Y-80..Endothelial X41_Y-80..Endothelial X37_Y-81..Endothelial #> PDK4                         0                     0             0.5553547 #> TNFRSF17                     0                     0             0.0000000 #> ICAM3                        0                     0             0.0000000 #> FAP                          0                     0             0.1856786 #> GZMB                         0                     0             0.0000000 #> TSC2                         0                     0             0.0000000 #>          X41_Y-81..Endothelial X37_Y-82..Endothelial X41_Y-82..Endothelial #> PDK4                 1.2114232             1.2754509             1.1961703 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.4697061             0.6165513             0.5535088 #> GZMB                 0.0000000             0.3070563             0.0000000 #> TSC2                 0.2488836             0.0000000             0.0000000 #>          X37_Y-83..Endothelial X41_Y-83..Endothelial X38_Y-83..Endothelial #> PDK4                 1.0091046             0.3190755             2.0920123 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.1414354             0.0000000             0.0000000 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.1685195             0.0000000             0.6740781 #>          X36_Y-84..Endothelial X37_Y-84..Endothelial X38_Y-84..Endothelial #> PDK4                 1.1049096             1.5571309             2.5171006 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.4531468             0.6473422 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.3834037             0.2396273             0.0000000 #>          X39_Y-84..Endothelial X37_Y-85..Endothelial X39_Y-85..Endothelial #> PDK4                  2.212341             1.1918944              2.212341 #> TNFRSF17              0.000000             0.0000000              0.000000 #> ICAM3                 0.000000             0.0000000              0.000000 #> FAP                   1.159644             0.0000000              1.159644 #> GZMB                  0.000000             0.0000000              0.000000 #> TSC2                  0.000000             0.3485488              0.000000 #>          X46_Y-72..Endothelial X47_Y-73..Endothelial X43_Y-74..Endothelial #> PDK4                 0.2278723                     0                     0 #> TNFRSF17             0.0000000                     0                     0 #> ICAM3                0.0000000                     0                     0 #> FAP                  0.1819280                     0                     0 #> GZMB                 0.1557906                     0                     0 #> TSC2                 0.1540726                     0                     0 #>          X46_Y-75..Endothelial X42_Y-76..Endothelial X45_Y-76..Endothelial #> PDK4                         0              1.611570             1.7989473 #> TNFRSF17                     0              0.000000             0.0000000 #> ICAM3                        0              0.000000             0.0000000 #> FAP                          0              1.024427             0.8439578 #> GZMB                         0              0.000000             0.0000000 #> TSC2                         0              0.000000             0.0000000 #>          X46_Y-76..Endothelial X45_Y-77..Endothelial X44_Y-77..Endothelial #> PDK4                 0.5686649             2.2888905             0.2838139 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.2230008             0.3609725 #> GZMB                 0.0000000             0.1755857             0.0000000 #> TSC2                 0.0000000             0.0000000             0.2308726 #>          X46_Y-77..Endothelial X47_Y-77..Endothelial X44_Y-78..Endothelial #> PDK4                 1.7884013                     0             0.4241317 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.1734451                     0             0.0000000 #> GZMB                 0.1365667                     0             0.0000000 #> TSC2                 0.0000000                     0             0.0000000 #>          X46_Y-78..Endothelial X45_Y-78..Endothelial X45_Y-79..Endothelial #> PDK4                 0.9057411             0.5318199             0.2625966 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.4670385             0.4687512 #> GZMB                 0.0000000             0.5350707             0.3302251 #> TSC2                 0.0000000             0.0000000             0.3132703 #>          X44_Y-79..Endothelial X46_Y-73..Endothelial X47_Y-75..Endothelial #> PDK4                 0.5360161             0.0000000                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.2083403             0.1930487                     0 #> GZMB                 0.2425889             0.1557906                     0 #> TSC2                 0.0000000             0.1540726                     0 #>          X47_Y-78..Endothelial X46_Y-79..Endothelial X75_Y-80..Endothelial #> PDK4                  0.000000                     0              0.000000 #> TNFRSF17              0.000000                     0              0.000000 #> ICAM3                 0.000000                     0              0.000000 #> FAP                   3.579154                     0              0.000000 #> GZMB                  0.000000                     0              0.000000 #> TSC2                  0.000000                     0              1.302541 #>          X79_Y-80..Endothelial X77_Y-80..Endothelial X78_Y-80..Endothelial #> PDK4                 0.6724577                     0             0.6724577 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.0000000                     0             0.0000000 #> GZMB                 0.0000000                     0             0.0000000 #> TSC2                 0.0000000                     0             0.0000000 #>          X73_Y-80..Endothelial X74_Y-80..Endothelial X75_Y-81..Endothelial #> PDK4                         0             0.8990608             0.9165616 #> TNFRSF17                     0             0.0000000             0.0000000 #> ICAM3                        0             0.0000000             0.0000000 #> FAP                          0             0.0000000             0.0000000 #> GZMB                         0             0.0000000             0.0000000 #> TSC2                         0             0.0000000             0.4341803 #>          X73_Y-81..Endothelial X75_Y-82..Endothelial X78_Y-82..Endothelial #> PDK4                         0             0.8171265              0.000000 #> TNFRSF17                     0             0.0000000              0.000000 #> ICAM3                        0             0.0000000              0.000000 #> FAP                          0             0.0000000              0.758152 #> GZMB                         0             1.6963892              0.000000 #> TSC2                         0             0.0000000              0.000000 #>          X73_Y-82..Endothelial X78_Y-84..Endothelial X75_Y-79..Endothelial #> PDK4                         0             0.9722751              1.637883 #> TNFRSF17                     0             0.0000000              0.000000 #> ICAM3                        0             0.0000000              0.000000 #> FAP                          0             0.0000000              0.000000 #> GZMB                         0             0.0000000              0.000000 #> TSC2                         0             0.0000000              0.000000 #>          X77_Y-81..Endothelial X77_Y-82..Endothelial X79_Y-82..Endothelial #> PDK4                         0                     0              0.000000 #> TNFRSF17                     0                     0              0.000000 #> ICAM3                        0                     0              0.000000 #> FAP                          0                     0              0.758152 #> GZMB                         0                     0              0.000000 #> TSC2                         0                     0              0.000000 #>          X78_Y-67..Endothelial X74_Y-67..Endothelial X74_Y-68..Endothelial #> PDK4                 0.0000000             1.2846714             0.4514337 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.5084773             0.0000000             0.0000000 #> GZMB                 0.3612125             0.9541226             0.4240545 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X78_Y-68..Endothelial X77_Y-68..Endothelial X77_Y-69..Endothelial #> PDK4                 0.4741097              0.000000             2.4542074 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.8044795              1.104608             0.9840804 #> GZMB                 0.0000000              0.000000             0.0000000 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X73_Y-69..Endothelial X73_Y-70..Endothelial X76_Y-70..Endothelial #> PDK4                 0.9455837              1.891167              0.504238 #> TNFRSF17             0.0000000              0.000000              0.000000 #> ICAM3                0.0000000              0.000000              0.000000 #> FAP                  1.1279623              0.000000              0.000000 #> GZMB                 0.0000000              0.000000              0.000000 #> TSC2                 0.0000000              0.000000              0.000000 #>          X75_Y-70..Endothelial X77_Y-70..Endothelial X76_Y-71..Endothelial #> PDK4                         0             0.7059333              1.764833 #> TNFRSF17                     0             0.0000000              0.000000 #> ICAM3                        0             0.0000000              0.000000 #> FAP                          0             0.0000000              0.000000 #> GZMB                         0             0.0000000              0.000000 #> TSC2                         0             0.0000000              0.000000 #>          X77_Y-71..Endothelial X73_Y-71..Endothelial X78_Y-71..Endothelial #> PDK4                         0                     0              1.937366 #> TNFRSF17                     0                     0              0.000000 #> ICAM3                        0                     0              0.000000 #> FAP                          0                     0              0.000000 #> GZMB                         0                     0              0.000000 #> TSC2                         0                     0              0.000000 #>          X78_Y-72..Endothelial X77_Y-72..Endothelial X75_Y-72..Endothelial #> PDK4                  1.937366             0.7995658                     0 #> TNFRSF17              0.000000             0.0000000                     0 #> ICAM3                 0.000000             0.0000000                     0 #> FAP                   0.000000             0.0000000                     0 #> GZMB                  0.000000             0.0000000                     0 #> TSC2                  0.000000             0.0000000                     0 #>          X76_Y-69..Endothelial X74_Y-72..Endothelial X56_Y-67..Endothelial #> PDK4                         0              2.323947             0.0000000 #> TNFRSF17                     0              0.000000             0.0000000 #> ICAM3                        0              0.000000             0.0000000 #> FAP                          0              1.096645             0.0000000 #> GZMB                         0              0.000000             0.3598959 #> TSC2                         0              0.000000             0.0000000 #>          X57_Y-67..Endothelial X59_Y-67..Endothelial X59_Y-68..Endothelial #> PDK4                 0.0000000              3.627803              1.209268 #> TNFRSF17             0.0000000              0.000000              0.000000 #> ICAM3                0.0000000              0.000000              0.000000 #> FAP                  0.0000000              0.000000              1.178706 #> GZMB                 0.4627233              0.000000              0.000000 #> TSC2                 0.0000000              0.000000              0.000000 #>          X60_Y-68..Endothelial X61_Y-68..Endothelial X58_Y-68..Endothelial #> PDK4                  0.000000              0.000000              0.000000 #> TNFRSF17              0.000000              0.000000              0.000000 #> ICAM3                 0.000000              0.000000              0.000000 #> FAP                   1.792769              4.548155              3.729311 #> GZMB                  0.000000              0.000000              0.000000 #> TSC2                  0.000000              0.000000              0.000000 #>          X60_Y-71..Endothelial X61_Y-71..Endothelial X59_Y-71..Endothelial #> PDK4                 0.9403977             0.7523182             0.7877239 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.9169646             0.7335717             0.3810179 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.4050890 #>          X59_Y-72..Endothelial X58_Y-72..Endothelial X60_Y-72..Endothelial #> PDK4                 0.2433096             0.2270890             0.7877239 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.3363243             0.3139026             0.3810179 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.4050890 #>          X57_Y-72..Endothelial X57_Y-66..Endothelial X58_Y-71..Endothelial #> PDK4                 0.8220544                     0                     0 #> TNFRSF17             0.0000000                     0                     0 #> ICAM3                0.0000000                     0                     0 #> FAP                  0.8220544                     0                     0 #> GZMB                 0.4217487                     0                     0 #> TSC2                 0.0000000                     0                     0 #>          X44_Y-80..Endothelial X45_Y-80..Endothelial X46_Y-80..Endothelial #> PDK4                 0.7767131                     0              0.000000 #> TNFRSF17             0.0000000                     0              0.000000 #> ICAM3                0.0000000                     0              0.000000 #> FAP                  0.0000000                     0              4.248003 #> GZMB                 0.4122471                     0              0.000000 #> TSC2                 0.0000000                     0              0.000000 #>          X44_Y-81..Endothelial X43_Y-81..Endothelial X46_Y-81..Endothelial #> PDK4                 0.6665598             0.4512738             2.4226966 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.4748495             0.9928064 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X43_Y-82..Endothelial X46_Y-82..Endothelial X43_Y-83..Endothelial #> PDK4                 1.0453823              3.452557             0.7626061 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.7268276              0.000000             0.4043413 #> GZMB                 0.3773529              0.000000             0.4779803 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X42_Y-83..Endothelial X45_Y-83..Endothelial X42_Y-84..Endothelial #> PDK4                  0.000000                     0             0.7668495 #> TNFRSF17              0.000000                     0             0.0000000 #> ICAM3                 0.000000                     0             0.0000000 #> FAP                   1.849044                     0             0.1661797 #> GZMB                  0.000000                     0             0.2560750 #> TSC2                  0.000000                     0             0.0000000 #>          X45_Y-84..Endothelial X43_Y-84..Endothelial X43_Y-85..Endothelial #> PDK4                         0             0.7668495             0.8332759 #> TNFRSF17                     0             0.0000000             0.0000000 #> ICAM3                        0             0.0000000             0.0000000 #> FAP                          0             0.1661797             0.2721868 #> GZMB                         0             0.2560750             0.0000000 #> TSC2                         0             0.0000000             0.0000000 #>          X48_Y-79..Endothelial X47_Y-80..Endothelial X48_Y-80..Endothelial #> PDK4                         0              1.356178             0.8137071 #> TNFRSF17                     0              0.000000             0.0000000 #> ICAM3                        0              0.000000             0.0000000 #> FAP                          0              1.416001             0.0000000 #> GZMB                         0              0.000000             0.0000000 #> TSC2                         0              0.000000             0.0000000 #>          X43_Y-80..Endothelial X47_Y-81..Endothelial X44_Y-85..Endothelial #> PDK4                 0.8680911               4.15104             1.7659767 #> TNFRSF17             0.0000000               0.00000             0.0000000 #> ICAM3                0.0000000               0.00000             0.0000000 #> FAP                  0.0000000               0.00000             0.3747638 #> GZMB                 0.4607468               0.00000             0.9412695 #> TSC2                 0.0000000               0.00000             0.0000000 #>          X49_Y-91..Endothelial X50_Y-91..Endothelial X53_Y-91..Endothelial #> PDK4                  3.246155             1.8168812             0.0000000 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             0.6971418             0.5997176 #> GZMB                  0.000000             0.0000000             0.3164890 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X54_Y-91..Endothelial X51_Y-92..Endothelial X52_Y-92..Endothelial #> PDK4                 1.0224777             0.0000000                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.6939495             0.7482577                     0 #> GZMB                 0.0000000             0.0000000                     0 #> TSC2                 0.0000000             0.0000000                     0 #>          X53_Y-93..Endothelial X52_Y-93..Endothelial X51_Y-93..Endothelial #> PDK4                  1.812631                     0              1.431806 #> TNFRSF17              0.000000                     0              0.000000 #> ICAM3                 0.000000                     0              0.000000 #> FAP                   0.000000                     0              0.000000 #> GZMB                  0.000000                     0              0.000000 #> TSC2                  0.000000                     0              0.000000 #>          X49_Y-94..Endothelial X50_Y-94..Endothelial X53_Y-94..Endothelial #> PDK4                 1.7078328              1.060582              1.625456 #> TNFRSF17             0.0000000              0.000000              0.000000 #> ICAM3                0.0000000              0.000000              0.000000 #> FAP                  0.6563945              0.746119              1.625456 #> GZMB                 0.0000000              0.000000              0.000000 #> TSC2                 0.0000000              0.000000              0.000000 #>          X48_Y-94..Endothelial X51_Y-94..Endothelial X51_Y-95..Endothelial #> PDK4                 1.4613203             0.7954477             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.9161118             0.0000000             0.0000000 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.4790215             0.8622388 #>          X50_Y-96..Endothelial X48_Y-96..Endothelial X49_Y-96..Endothelial #> PDK4                         0              1.112724              1.112724 #> TNFRSF17                     0              0.000000              0.000000 #> ICAM3                        0              0.000000              0.000000 #> FAP                          0              0.000000              0.000000 #> GZMB                         0              1.112724              1.112724 #> TSC2                         0              0.000000              0.000000 #>          X54_Y-96..Endothelial X53_Y-97..Endothelial X54_Y-97..Endothelial #> PDK4                         0                     0                     0 #> TNFRSF17                     0                     0                     0 #> ICAM3                        0                     0                     0 #> FAP                          0                     0                     0 #> GZMB                         0                     0                     0 #> TSC2                         0                     0                     0 #>          X53_Y-92..Endothelial X71_Y-81..Endothelial X68_Y-81..Endothelial #> PDK4                  1.450105              1.154826             0.6297731 #> TNFRSF17              0.000000              0.000000             0.0000000 #> ICAM3                 0.000000              0.000000             0.0000000 #> FAP                   0.000000              0.000000             0.7093338 #> GZMB                  0.000000              0.000000             0.4289972 #> TSC2                  0.000000              0.000000             0.3886734 #>          X67_Y-82..Endothelial X67_Y-83..Endothelial X70_Y-84..Endothelial #> PDK4                  1.961004             0.9056173                     0 #> TNFRSF17              0.000000             0.0000000                     0 #> ICAM3                 0.000000             0.0000000                     0 #> FAP                   0.759325             0.0000000                     0 #> GZMB                  0.000000             0.9264497                     0 #> TSC2                  0.000000             0.0000000                     0 #>          X67_Y-84..Endothelial X68_Y-84..Endothelial X72_Y-84..Endothelial #> PDK4                  0.000000             0.8641793                     0 #> TNFRSF17              0.000000             0.0000000                     0 #> ICAM3                 0.000000             0.0000000                     0 #> FAP                   0.000000             0.4120760                     0 #> GZMB                  1.498467             1.2410277                     0 #> TSC2                  0.000000             0.0000000                     0 #>          X72_Y-85..Endothelial X69_Y-85..Endothelial X68_Y-85..Endothelial #> PDK4                  1.323351              1.022033                     0 #> TNFRSF17              0.000000              0.000000                     0 #> ICAM3                 0.000000              0.000000                     0 #> FAP                   0.000000              0.000000                     0 #> GZMB                  0.000000              0.000000                     0 #> TSC2                  0.000000              0.000000                     0 #>          X67_Y-81..Endothelial X69_Y-84..Endothelial X71_Y-85..Endothelial #> PDK4                 0.6297731             1.3163354             0.8822341 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.7093338             0.3433967             0.5653910 #> GZMB                 0.4289972             0.7186450             0.5653910 #> TSC2                 0.3886734             0.0000000             0.0000000 #>          X67_Y-85..Endothelial X51_Y-67..Endothelial X51_Y-68..Endothelial #> PDK4                         0             0.3690301                     0 #> TNFRSF17                     0             0.0000000                     0 #> ICAM3                        0             0.0000000                     0 #> FAP                          0             0.3690301                     0 #> GZMB                         0             0.0000000                     0 #> TSC2                         0             0.0000000                     0 #>          X50_Y-68..Endothelial X52_Y-68..Endothelial X49_Y-68..Endothelial #> PDK4                         0             0.6540389             1.0765494 #> TNFRSF17                     0             0.0000000             0.0000000 #> ICAM3                        0             0.0000000             0.0000000 #> FAP                          0             0.0000000             0.0000000 #> GZMB                         0             0.0000000             0.4961083 #> TSC2                         0             0.0000000             0.0000000 #>          X52_Y-69..Endothelial X50_Y-69..Endothelial X49_Y-69..Endothelial #> PDK4                  3.270194             0.7414604             0.8295212 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             0.0000000             0.3720026 #> GZMB                  0.000000             0.0000000             0.2480542 #> TSC2                  0.000000             0.0000000             0.2996869 #>          X49_Y-70..Endothelial X51_Y-70..Endothelial X48_Y-70..Endothelial #> PDK4                 0.0000000                     0             0.6158943 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.8928064                     0             0.0000000 #> GZMB                 0.0000000                     0             0.4233511 #> TSC2                 0.7192486                     0             0.0000000 #>          X53_Y-70..Endothelial X48_Y-71..Endothelial X53_Y-71..Endothelial #> PDK4                 0.4254884             0.0000000             0.4254884 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.5350449             0.0000000 #> GZMB                 0.0000000             0.4838298             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X53_Y-72..Endothelial X52_Y-72..Endothelial X50_Y-67..Endothelial #> PDK4                  2.855339              1.070752             0.4920402 #> TNFRSF17              0.000000              0.000000             0.0000000 #> ICAM3                 0.000000              0.000000             0.0000000 #> FAP                   0.000000              0.000000             0.4920402 #> GZMB                  1.396223              1.084268             0.0000000 #> TSC2                  0.000000              0.000000             0.0000000 #>          X61_Y-64..Endothelial X64_Y-64..Endothelial X65_Y-64..Endothelial #> PDK4                         0                     0             0.6771505 #> TNFRSF17                     0                     0             0.0000000 #> ICAM3                        0                     0             0.0000000 #> FAP                          0                     0             1.2550956 #> GZMB                         0                     0             0.0000000 #> TSC2                         0                     0             0.0000000 #>          X65_Y-65..Endothelial X66_Y-65..Endothelial X64_Y-65..Endothelial #> PDK4                 0.4062903             0.0000000                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  1.1492270             0.3601542                     0 #> GZMB                 0.0000000             0.0000000                     0 #> TSC2                 0.0000000             0.0000000                     0 #>          X67_Y-65..Endothelial X64_Y-66..Endothelial X67_Y-66..Endothelial #> PDK4                 0.4168962              1.479724             0.3527584 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.4147386              0.000000             0.3509326 #> GZMB                 0.0000000              0.000000             0.0000000 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X56_Y-80..Endothelial X59_Y-80..Endothelial X58_Y-80..Endothelial #> PDK4                    0.0000             0.1890120                     0 #> TNFRSF17                0.0000             0.0000000                     0 #> ICAM3                   0.0000             0.0000000                     0 #> FAP                     0.0000             0.3324506                     0 #> GZMB                    1.3209             0.0000000                     0 #> TSC2                    0.0000             0.0000000                     0 #>          X55_Y-80..Endothelial X60_Y-80..Endothelial X56_Y-81..Endothelial #> PDK4                  0.000000             0.2700171              1.541719 #> TNFRSF17              0.000000             0.0000000              0.000000 #> ICAM3                 0.000000             0.0000000              0.000000 #> FAP                   1.164986             0.7863926              0.000000 #> GZMB                  0.000000             0.0000000              0.000000 #> TSC2                  0.000000             0.0000000              0.000000 #>          X60_Y-81..Endothelial X54_Y-81..Endothelial X57_Y-82..Endothelial #> PDK4                  0.472530             0.0000000             1.1801968 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   1.376187             0.0000000             0.0000000 #> GZMB                  0.000000             0.8834118             0.5489903 #> TSC2                  0.000000             0.6981683             0.0000000 #>          X56_Y-82..Endothelial X57_Y-83..Endothelial X58_Y-83..Endothelial #> PDK4                 1.9031917             1.3500076             0.8267464 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.0000000             0.0000000 #> GZMB                 0.9607331             0.4269925             0.0000000 #> TSC2                 0.0000000             0.0000000             0.3523260 #>          X59_Y-84..Endothelial X57_Y-84..Endothelial X60_Y-84..Endothelial #> PDK4                 0.0000000                     0             0.0000000 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.7272242                     0             0.6233351 #> GZMB                 0.0000000                     0             0.4166893 #> TSC2                 0.0000000                     0             0.0000000 #>          X59_Y-81..Endothelial X60_Y-85..Endothelial X61_Y-85..Endothelial #> PDK4                  0.000000             0.0000000             0.9032628 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   2.348855             0.0000000             0.0000000 #> GZMB                  0.000000             0.4861375             0.0000000 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X63_Y-81..Endothelial X61_Y-83..Endothelial X64_Y-83..Endothelial #> PDK4                  3.820847              0.000000                     0 #> TNFRSF17              0.000000              0.000000                     0 #> ICAM3                 0.000000              0.000000                     0 #> FAP                   0.000000              0.000000                     0 #> GZMB                  0.000000              4.576296                     0 #> TSC2                  0.000000              0.000000                     0 #>          X63_Y-84..Endothelial X64_Y-84..Endothelial X62_Y-84..Endothelial #> PDK4                  0.000000                     0                     0 #> TNFRSF17              0.000000                     0                     0 #> ICAM3                 0.000000                     0                     0 #> FAP                   3.624244                     0                     0 #> GZMB                  0.000000                     0                     0 #> TSC2                  3.624244                     0                     0 #>          X64_Y-85..Endothelial X63_Y-80..Endothelial X34_Y-91..Endothelial #> PDK4                         0                     0              1.051668 #> TNFRSF17                     0                     0              0.000000 #> ICAM3                        0                     0              0.000000 #> FAP                          0                     0              0.184522 #> GZMB                         0                     0              0.000000 #> TSC2                         0                     0              0.000000 #>          X31_Y-91..Endothelial X34_Y-92..Endothelial X33_Y-92..Endothelial #> PDK4                 0.4096266             1.1016718              0.000000 #> TNFRSF17             0.0000000             0.0000000              0.000000 #> ICAM3                0.0000000             0.0000000              0.000000 #> FAP                  0.0000000             0.2323427              3.717483 #> GZMB                 0.0000000             0.0000000              0.000000 #> TSC2                 0.0000000             0.0000000              0.000000 #>          X31_Y-92..Endothelial X30_Y-92..Endothelial X36_Y-92..Endothelial #> PDK4                         0                     0             1.5295955 #> TNFRSF17                     0                     0             0.0000000 #> ICAM3                        0                     0             0.0000000 #> FAP                          0                     0             0.5820287 #> GZMB                         0                     0             0.0000000 #> TSC2                         0                     0             0.0000000 #>          X35_Y-93..Endothelial X34_Y-93..Endothelial X31_Y-94..Endothelial #> PDK4                 1.3939360              1.101018                     0 #> TNFRSF17             0.0000000              0.000000                     0 #> ICAM3                0.0000000              0.000000                     0 #> FAP                  0.4612267              0.518880                     0 #> GZMB                 0.0000000              0.000000                     0 #> TSC2                 0.0000000              0.000000                     0 #>          X30_Y-94..Endothelial X35_Y-94..Endothelial X34_Y-94..Endothelial #> PDK4                 0.3622782             0.3336533             0.4408072 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.3622782             0.0000000             0.0000000 #> GZMB                 0.0000000             0.2707686             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X35_Y-95..Endothelial X34_Y-95..Endothelial X34_Y-96..Endothelial #> PDK4                 1.0588806             0.8850696             0.8050502 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.6558599             0.3980759 #> GZMB                 0.2527173             0.0000000             0.0000000 #> TSC2                 0.0000000             0.1884917             0.0000000 #>          X35_Y-96..Endothelial X35_Y-97..Endothelial X32_Y-91..Endothelial #> PDK4                 0.9412877             1.3125050                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.6628582             0.9956266                     0 #> GZMB                 0.3079424             0.3341021                     0 #> TSC2                 0.0000000             0.0000000                     0 #>          X35_Y-92..Endothelial X45_Y-85..Endothelial X43_Y-86..Endothelial #> PDK4                 0.9343198             1.7659767             1.2273353 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.3747638             0.0000000 #> GZMB                 0.0000000             0.9412695             0.0000000 #> TSC2                 0.0000000             0.0000000             0.2112441 #>          X44_Y-86..Endothelial X42_Y-86..Endothelial X45_Y-87..Endothelial #> PDK4                  1.925955             0.8095856              0.000000 #> TNFRSF17              0.000000             0.0000000              0.000000 #> ICAM3                 0.000000             0.0000000              0.000000 #> FAP                   0.000000             0.0000000              0.000000 #> GZMB                  0.000000             0.4188705              0.000000 #> TSC2                  0.000000             0.4459597              1.538374 #>          X43_Y-87..Endothelial X42_Y-87..Endothelial X46_Y-87..Endothelial #> PDK4                 0.6131804             0.7135307             0.9210538 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.0000000             0.0000000 #> GZMB                 0.0000000             0.3769834             0.9210538 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X48_Y-88..Endothelial X43_Y-88..Endothelial X44_Y-88..Endothelial #> PDK4                  0.000000              0.792432             0.0000000 #> TNFRSF17              0.000000              0.000000             0.0000000 #> ICAM3                 0.000000              0.000000             0.0000000 #> FAP                   0.000000              0.340352             0.3886734 #> GZMB                  0.000000              0.000000             0.0000000 #> TSC2                  1.262179              0.000000             0.0000000 #>          X45_Y-88..Endothelial X42_Y-88..Endothelial X47_Y-88..Endothelial #> PDK4                         0             0.3094109              0.000000 #> TNFRSF17                     0             0.0000000              0.000000 #> ICAM3                        0             0.0000000              0.000000 #> FAP                          0             0.3094109              0.000000 #> GZMB                         0             0.0000000              1.085163 #> TSC2                         0             0.0000000              0.000000 #>          X44_Y-89..Endothelial X42_Y-89..Endothelial X45_Y-89..Endothelial #> PDK4                 0.4640191             0.3971968              0.000000 #> TNFRSF17             0.0000000             0.0000000              0.000000 #> ICAM3                0.0000000             0.0000000              0.000000 #> FAP                  0.3498060             0.0000000              0.000000 #> GZMB                 0.0000000             0.0000000              1.019963 #> TSC2                 0.0000000             0.0000000              0.000000 #>          X48_Y-89..Endothelial X46_Y-89..Endothelial X43_Y-89..Endothelial #> PDK4                 0.0000000             0.0000000             0.6514805 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.4691772             0.0000000 #> GZMB                 0.8681304             0.0000000             0.0000000 #> TSC2                 0.0000000             0.4134331             0.0000000 #>          X47_Y-89..Endothelial X46_Y-90..Endothelial X47_Y-90..Endothelial #> PDK4                         0             0.0000000             0.2481084 #> TNFRSF17                     0             0.0000000             0.0000000 #> ICAM3                        0             0.0000000             0.0000000 #> FAP                          0             0.1876709             0.0000000 #> GZMB                         0             0.1286556             0.7217158 #> TSC2                         0             0.1653732             0.1982097 #>          X48_Y-90..Endothelial X43_Y-90..Endothelial X45_Y-90..Endothelial #> PDK4                 0.3162500             0.5427514             0.1979739 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.5681410             0.5386514 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.2897126             0.0000000             0.0000000 #>          X46_Y-91..Endothelial X47_Y-91..Endothelial X42_Y-85..Endothelial #> PDK4                  0.000000              1.487489             1.3767908 #> TNFRSF17              0.000000              0.000000             0.0000000 #> ICAM3                 0.000000              0.000000             0.0000000 #> FAP                   1.330841              0.000000             0.0000000 #> GZMB                  0.000000              0.000000             0.3414334 #> TSC2                  0.000000              0.000000             0.0000000 #>          X48_Y-86..Endothelial X46_Y-88..Endothelial X53_Y-79..Endothelial #> PDK4                  3.532886                     0              2.787856 #> TNFRSF17              0.000000                     0              0.000000 #> ICAM3                 0.000000                     0              0.000000 #> FAP                   0.000000                     0              0.000000 #> GZMB                  0.000000                     0              0.000000 #> TSC2                  0.000000                     0              0.000000 #>          X51_Y-79..Endothelial X49_Y-80..Endothelial X54_Y-80..Endothelial #> PDK4                         0              1.090686             0.3592662 #> TNFRSF17                     0              0.000000             0.0000000 #> ICAM3                        0              0.000000             0.0000000 #> FAP                          0              0.000000             0.0000000 #> GZMB                         0              0.000000             0.0000000 #> TSC2                         0              0.000000             0.7978480 #>          X50_Y-80..Endothelial X53_Y-80..Endothelial X51_Y-80..Endothelial #> PDK4                 0.0000000             0.0000000                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.4347128             0.0000000                     0 #> GZMB                 0.0000000             0.5251932                     0 #> TSC2                 0.0000000             0.0000000                     0 #>          X50_Y-81..Endothelial X51_Y-81..Endothelial X50_Y-82..Endothelial #> PDK4                 0.0000000              0.000000             0.2230008 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.3580660              0.000000             0.3069137 #> GZMB                 0.6501403              1.106986             0.3371065 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X53_Y-82..Endothelial X54_Y-82..Endothelial X51_Y-83..Endothelial #> PDK4                         0                     0                     0 #> TNFRSF17                     0                     0                     0 #> ICAM3                        0                     0                     0 #> FAP                          0                     0                     0 #> GZMB                         0                     0                     0 #> TSC2                         0                     0                     0 #>          X54_Y-83..Endothelial X52_Y-84..Endothelial X51_Y-85..Endothelial #> PDK4                         0                     0             0.0000000 #> TNFRSF17                     0                     0             0.0000000 #> ICAM3                        0                     0             0.0000000 #> FAP                          0                     0             0.4742904 #> GZMB                         0                     0             0.3452900 #> TSC2                         0                     0             0.0000000 #>          X49_Y-85..Endothelial X52_Y-85..Endothelial X53_Y-81..Endothelial #> PDK4                         0             0.0000000                     0 #> TNFRSF17                     0             0.0000000                     0 #> ICAM3                        0             0.0000000                     0 #> FAP                          0             0.6098019                     0 #> GZMB                         0             0.0000000                     0 #> TSC2                         0             0.0000000                     0 #>          X70_Y-91..Endothelial X68_Y-91..Endothelial X73_Y-95..Endothelial #> PDK4                 0.3084625             0.3312549             0.8551164 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.2419149             0.0000000             0.0000000 #> GZMB                 0.0000000             0.0000000             0.9461129 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X72_Y-95..Endothelial X72_Y-96..Endothelial X68_Y-96..Endothelial #> PDK4                  1.508544             0.8607933             0.5491457 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             0.0000000             0.5976588 #> GZMB                  0.000000             0.0000000             0.8972003 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X68_Y-97..Endothelial X68_Y-92..Endothelial X72_Y-93..Endothelial #> PDK4                 0.0000000             0.2760458              0.925484 #> TNFRSF17             0.0000000             0.0000000              0.000000 #> ICAM3                0.0000000             0.0000000              0.000000 #> FAP                  0.5122789             0.0000000              0.000000 #> GZMB                 0.0000000             0.0000000              0.000000 #> TSC2                 0.0000000             0.0000000              0.000000 #>          X72_Y-94..Endothelial X76_Y-92..Endothelial X76_Y-93..Endothelial #> PDK4                  1.923483                     0                     0 #> TNFRSF17              0.000000                     0                     0 #> ICAM3                 0.000000                     0                     0 #> FAP                   0.000000                     0                     0 #> GZMB                  0.000000                     0                     0 #> TSC2                  0.000000                     0                     0 #>          X75_Y-93..Endothelial X73_Y-93..Endothelial X73_Y-94..Endothelial #> PDK4                 0.6949454                     0                     0 #> TNFRSF17             0.0000000                     0                     0 #> ICAM3                0.0000000                     0                     0 #> FAP                  0.0000000                     0                     0 #> GZMB                 0.7659193                     0                     0 #> TSC2                 0.0000000                     0                     0 #>          X75_Y-95..Endothelial X74_Y-95..Endothelial X74_Y-96..Endothelial #> PDK4                 0.6667555             0.5417388             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.5535815             0.4497849             0.4348158 #> GZMB                 0.6060354             0.4924038             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X76_Y-96..Endothelial X74_Y-97..Endothelial X43_Y-67..Endothelial #> PDK4                  0.000000              4.476843                     0 #> TNFRSF17              0.000000              0.000000                     0 #> ICAM3                 0.000000              0.000000                     0 #> FAP                   4.485477              0.000000                     0 #> GZMB                  0.000000              0.000000                     0 #> TSC2                  0.000000              0.000000                     0 #>          X46_Y-68..Endothelial X44_Y-68..Endothelial X45_Y-69..Endothelial #> PDK4                 1.4266966                     0             1.4458966 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.2527638                     0             0.0000000 #> GZMB                 0.0000000                     0             0.2096740 #> TSC2                 0.2499935                     0             0.2392914 #>          X45_Y-70..Endothelial X47_Y-71..Endothelial X46_Y-71..Endothelial #> PDK4                 1.9854366             0.0000000             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.0000000             0.3718910 #> GZMB                 0.0000000             0.4402383             0.4167104 #> TSC2                 0.5127672             0.2575351             0.0000000 #>          X47_Y-72..Endothelial X74_Y-65..Endothelial X74_Y-66..Endothelial #> PDK4                 0.3672148              0.000000              0.000000 #> TNFRSF17             0.0000000              0.000000              0.000000 #> ICAM3                0.0000000              0.000000              0.000000 #> FAP                  0.8394848              0.000000              0.000000 #> GZMB                 0.0000000              0.000000              0.000000 #> TSC2                 0.2861501              2.057408              1.028704 #>          X76_Y-66..Endothelial X22_Y-92..Endothelial X23_Y-85..Endothelial #> PDK4                  3.709678                     0             0.5759205 #> TNFRSF17              0.000000                     0             0.0000000 #> ICAM3                 0.000000                     0             0.0000000 #> FAP                   0.000000                     0             0.7046366 #> GZMB                  0.000000                     0             0.7046366 #> TSC2                  0.000000                     0             0.0000000 #>          X25_Y-86..Endothelial X23_Y-86..Endothelial X25_Y-87..Endothelial #> PDK4                 0.7207074             0.8119371             0.3155448 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.8775429             0.4697577             0.0000000 #> GZMB                 0.0000000             0.4697577             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X26_Y-87..Endothelial X28_Y-87..Endothelial X27_Y-88..Endothelial #> PDK4                         0              1.129692             1.1331602 #> TNFRSF17                     0              0.000000             0.0000000 #> ICAM3                        0              0.000000             0.0000000 #> FAP                          0              1.131794             0.4637364 #> GZMB                         0              0.000000             0.5192801 #> TSC2                         0              0.000000             0.0000000 #>          X26_Y-88..Endothelial X25_Y-88..Endothelial X29_Y-88..Endothelial #> PDK4                 0.5741413              1.230147              0.000000 #> TNFRSF17             0.0000000              0.000000              0.000000 #> ICAM3                0.0000000              0.000000              0.000000 #> FAP                  0.5788194              0.000000              1.420565 #> GZMB                 0.0000000              0.000000              0.000000 #> TSC2                 0.0000000              1.230147              0.000000 #>          X26_Y-89..Endothelial X29_Y-89..Endothelial X28_Y-89..Endothelial #> PDK4                  1.723036             0.6762172             0.5071629 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             0.7125970             0.0000000 #> GZMB                  0.000000             0.0000000             0.0000000 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X27_Y-89..Endothelial X27_Y-90..Endothelial X28_Y-90..Endothelial #> PDK4                  1.938415             0.6773617             0.4539591 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             0.0000000             0.3961891 #> GZMB                  0.000000             0.0000000             0.0000000 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X25_Y-91..Endothelial X26_Y-86..Endothelial X24_Y-86..Endothelial #> PDK4                  1.279491             0.7731730             0.5409340 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             0.4340652             0.6335396 #> GZMB                  0.000000             0.0000000             0.0000000 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X28_Y-88..Endothelial X28_Y-91..Endothelial X26_Y-92..Endothelial #> PDK4                 0.5982284             0.0000000             0.6397457 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.7794003             0.5942836             0.0000000 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X33_Y-86..Endothelial X35_Y-86..Endothelial X32_Y-87..Endothelial #> PDK4                   1.20599             0.8132725             0.2806748 #> TNFRSF17               0.00000             0.0000000             0.0000000 #> ICAM3                  0.00000             0.0000000             0.0000000 #> FAP                    0.00000             0.5446317             0.4883605 #> GZMB                   0.00000             0.2301705             0.0000000 #> TSC2                   0.00000             0.2332040             0.0000000 #>          X35_Y-87..Endothelial X36_Y-87..Endothelial X33_Y-87..Endothelial #> PDK4                 1.0370420             0.9600078             0.9647917 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.4084738             0.2494840             0.0000000 #> GZMB                 0.1726278             0.0000000             0.0000000 #> TSC2                 0.1749030             0.0000000             0.0000000 #>          X35_Y-88..Endothelial X36_Y-88..Endothelial X32_Y-88..Endothelial #> PDK4                  1.567349             1.2286771             1.4268899 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             0.4512859             0.4132282 #> GZMB                  0.000000             0.0000000             0.0000000 #> TSC2                  0.000000             0.2191275             0.0000000 #>          X33_Y-89..Endothelial X34_Y-90..Endothelial X32_Y-90..Endothelial #> PDK4                 0.8091677             1.4626801             0.4565729 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.7615363             0.2636029             0.0000000 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X36_Y-90..Endothelial X33_Y-90..Endothelial X33_Y-91..Endothelial #> PDK4                 1.0126203                     0             0.9920182 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.4717726                     0             0.2323427 #> GZMB                 0.0000000                     0             0.0000000 #> TSC2                 0.0000000                     0             0.0000000 #>          X35_Y-91..Endothelial X36_Y-91..Endothelial X32_Y-89..Endothelial #> PDK4                  1.475318              1.774343             2.2413138 #> TNFRSF17              0.000000              0.000000             0.0000000 #> ICAM3                 0.000000              0.000000             0.0000000 #> FAP                   0.000000              0.000000             0.8567283 #> GZMB                  0.000000              0.000000             0.0000000 #> TSC2                  0.000000              0.000000             0.0000000 #>          X34_Y-89..Endothelial X41_Y-86..Endothelial X41_Y-88..Endothelial #> PDK4                  2.430359              2.305913                     0 #> TNFRSF17              0.000000              0.000000                     0 #> ICAM3                 0.000000              0.000000                     0 #> FAP                   0.000000              0.000000                     0 #> GZMB                  0.000000              0.000000                     0 #> TSC2                  0.000000              0.000000                     0 #>          X38_Y-88..Endothelial X41_Y-89..Endothelial X36_Y-89..Endothelial #> PDK4                         0              1.029928              3.158263 #> TNFRSF17                     0              0.000000              0.000000 #> ICAM3                        0              0.000000              0.000000 #> FAP                          0              0.000000              1.173387 #> GZMB                         0              0.000000              0.000000 #> TSC2                         0              0.000000              0.000000 #>          X37_Y-89..Endothelial X38_Y-89..Endothelial X39_Y-89..Endothelial #> PDK4                 2.2463073             1.2407674                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.2707117             0.1741323                     0 #> GZMB                 0.0000000             0.1741323                     0 #> TSC2                 0.0000000             0.0000000                     0 #>          X41_Y-90..Endothelial X37_Y-90..Endothelial X38_Y-90..Endothelial #> PDK4                   1.97208              1.458552             0.6253224 #> TNFRSF17               0.00000              0.000000             0.0000000 #> ICAM3                  0.00000              0.000000             0.0000000 #> FAP                    0.00000              0.000000             0.1774576 #> GZMB                   0.00000              0.000000             0.0000000 #> TSC2                   0.00000              0.000000             0.0000000 #>          X39_Y-91..Endothelial X30_Y-98..Endothelial X35_Y-98..Endothelial #> PDK4                 0.8163341              2.262268             1.0100580 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.0000000              0.000000             0.9757283 #> GZMB                 0.0000000              0.000000             0.4772887 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X35_Y-99..Endothelial X35_Y-100..Endothelial X34_Y-100..Endothelial #> PDK4                 2.6217793              1.4998373              1.5304628 #> TNFRSF17             0.0000000              0.0000000              0.0000000 #> ICAM3                0.0000000              0.0000000              0.0000000 #> FAP                  0.0000000              0.4656839              0.3333234 #> GZMB                 0.3761591              0.0000000              0.0000000 #> TSC2                 0.0000000              0.0000000              0.0000000 #>          X35_Y-101..Endothelial X33_Y-101..Endothelial X30_Y-101..Endothelial #> PDK4                  1.0496164              0.9389332              1.0612597 #> TNFRSF17              0.0000000              0.0000000              0.0000000 #> ICAM3                 0.0000000              0.0000000              0.0000000 #> FAP                   0.5322102              0.2257872              0.2283413 #> GZMB                  0.0000000              0.0000000              0.0000000 #> TSC2                  0.0000000              0.0000000              0.0000000 #>          X31_Y-101..Endothelial X34_Y-101..Endothelial X32_Y-101..Endothelial #> PDK4                  1.5469214              0.3959515                      0 #> TNFRSF17              0.0000000              0.0000000                      0 #> ICAM3                 0.0000000              0.0000000                      0 #> FAP                   0.3978199              0.3920430                      0 #> GZMB                  0.0000000              0.0000000                      0 #> TSC2                  0.0000000              0.0000000                      0 #>          X35_Y-102..Endothelial X32_Y-102..Endothelial X34_Y-102..Endothelial #> PDK4                   0.906726              0.7412148              0.0000000 #> TNFRSF17               0.000000              0.0000000              0.0000000 #> ICAM3                  0.000000              0.0000000              0.0000000 #> FAP                    0.150468              0.1769004              0.3697822 #> GZMB                   0.000000              0.0000000              0.0000000 #> TSC2                   0.000000              0.0000000              0.0000000 #>          X30_Y-102..Endothelial X31_Y-102..Endothelial X33_Y-102..Endothelial #> PDK4                  1.2790002              0.7958576              0.8074671 #> TNFRSF17              0.0000000              0.0000000              0.0000000 #> ICAM3                 0.0000000              0.0000000              0.0000000 #> FAP                   0.2743211              0.3814274              0.1592104 #> GZMB                  0.0000000              0.1796400              0.0000000 #> TSC2                  0.0000000              0.1899630              0.0000000 #>          X29_Y-102..Endothelial X35_Y-103..Endothelial X31_Y-103..Endothelial #> PDK4                  0.7099059              1.6175390              1.3757024 #> TNFRSF17              0.0000000              0.0000000              0.0000000 #> ICAM3                 0.0000000              0.0000000              0.0000000 #> FAP                   0.2463577              0.0000000              0.5325299 #> GZMB                  0.0000000              0.2406760              0.0000000 #> TSC2                  0.0000000              0.2483568              0.0000000 #>          X34_Y-103..Endothelial X30_Y-103..Endothelial X32_Y-103..Endothelial #> PDK4                  0.9727997              1.8693058               1.144242 #> TNFRSF17              0.0000000              0.0000000               0.000000 #> ICAM3                 0.0000000              0.0000000               0.000000 #> FAP                   0.3811256              0.3846049               0.000000 #> GZMB                  0.0000000              0.0000000               0.000000 #> TSC2                  0.1862676              0.0000000               0.000000 #>          X33_Y-103..Endothelial X30_Y-104..Endothelial X34_Y-104..Endothelial #> PDK4                   1.066544              1.5956090              0.3457859 #> TNFRSF17               0.000000              0.0000000              0.0000000 #> ICAM3                  0.000000              0.0000000              0.0000000 #> FAP                    0.000000              0.3095586              0.5178252 #> GZMB                   0.000000              0.0000000              0.0000000 #> TSC2                   0.000000              0.0000000              0.1935062 #>          X35_Y-104..Endothelial X31_Y-104..Endothelial X22_Y-86..Endothelial #> PDK4                  1.6471422              1.1781780             0.5206291 #> TNFRSF17              0.0000000              0.0000000             0.0000000 #> ICAM3                 0.0000000              0.0000000             0.0000000 #> FAP                   0.4093617              0.0000000             0.0000000 #> GZMB                  0.2427329              0.2699047             0.0000000 #> TSC2                  0.0000000              0.0000000             0.0000000 #>          X21_Y-86..Endothelial X22_Y-87..Endothelial X21_Y-91..Endothelial #> PDK4                 0.5206291              2.072317                     0 #> TNFRSF17             0.0000000              0.000000                     0 #> ICAM3                0.0000000              0.000000                     0 #> FAP                  0.0000000              0.000000                     0 #> GZMB                 0.0000000              0.000000                     0 #> TSC2                 0.0000000              0.000000                     0 #>          X22_Y-65..Endothelial X21_Y-65..Endothelial X22_Y-66..Endothelial #> PDK4                 1.0108618             0.8676740              1.401803 #> TNFRSF17             0.0000000             0.0000000              0.000000 #> ICAM3                0.0000000             0.0000000              0.000000 #> FAP                  0.4457561             0.6514897              0.000000 #> GZMB                 0.0000000             0.0000000              0.000000 #> TSC2                 0.0000000             0.0000000              0.000000 #>          X22_Y-64..Endothelial X23_Y-98..Endothelial X22_Y-98..Endothelial #> PDK4                 0.3786538             0.9215440                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.8469366             0.1801583                     0 #> GZMB                 0.0000000             0.0000000                     0 #> TSC2                 0.0000000             0.0000000                     0 #>          X22_Y-99..Endothelial X23_Y-99..Endothelial X24_Y-99..Endothelial #> PDK4                 1.1996715              2.006595             1.3765409 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.5705031              0.196837             0.6278154 #> GZMB                 0.3519396              0.000000             0.0000000 #> TSC2                 0.0000000              0.000000             0.2545412 #>          X22_Y-100..Endothelial X23_Y-100..Endothelial X23_Y-102..Endothelial #> PDK4                  2.0006514              1.7715678               1.537086 #> TNFRSF17              0.0000000              0.0000000               0.000000 #> ICAM3                 0.0000000              0.0000000               0.000000 #> FAP                   0.3250147              0.2761054               0.000000 #> GZMB                  0.0000000              0.0000000               0.000000 #> TSC2                  0.0000000              0.0000000               0.000000 #>          X21_Y-102..Endothelial X22_Y-102..Endothelial X23_Y-103..Endothelial #> PDK4                   1.850968               1.537086               1.384905 #> TNFRSF17               0.000000               0.000000               0.000000 #> ICAM3                  0.000000               0.000000               0.000000 #> FAP                    0.000000               0.000000               0.000000 #> GZMB                   0.000000               0.000000               0.000000 #> TSC2                   0.000000               0.000000               0.000000 #>          X21_Y-99..Endothelial X25_Y-98..Endothelial X27_Y-98..Endothelial #> PDK4                 0.0000000             0.2188409             0.5258986 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.8211924             0.0000000             0.6253808 #> GZMB                 0.8211924             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X29_Y-98..Endothelial X24_Y-100..Endothelial X28_Y-101..Endothelial #> PDK4                  2.262268              2.0732613                1.50293 #> TNFRSF17              0.000000              0.0000000                0.00000 #> ICAM3                 0.000000              0.0000000                0.00000 #> FAP                   0.000000              0.3988189                0.00000 #> GZMB                  0.000000              0.0000000                0.00000 #> TSC2                  0.000000              0.0000000                0.00000 #>          X27_Y-101..Endothelial X29_Y-101..Endothelial X27_Y-102..Endothelial #> PDK4                   1.630202              0.5002990              0.6211478 #> TNFRSF17               0.000000              0.0000000              0.0000000 #> ICAM3                  0.000000              0.0000000              0.0000000 #> FAP                    0.000000              0.1306000              0.3056033 #> GZMB                   0.000000              0.1332536              0.0000000 #> TSC2                   0.000000              0.0000000              0.0000000 #>          X28_Y-102..Endothelial X26_Y-102..Endothelial X25_Y-102..Endothelial #> PDK4                  0.5766403              0.7091657               1.262882 #> TNFRSF17              0.0000000              0.0000000               0.000000 #> ICAM3                 0.0000000              0.0000000               0.000000 #> FAP                   0.2031452              0.2375323               0.000000 #> GZMB                  0.1980848              0.0000000               0.000000 #> TSC2                  0.0000000              0.0000000               1.237857 #>          X28_Y-103..Endothelial X26_Y-103..Endothelial X26_Y-104..Endothelial #> PDK4                  0.3569178              0.7947346                1.45216 #> TNFRSF17              0.0000000              0.0000000                0.00000 #> ICAM3                 0.0000000              0.0000000                0.00000 #> FAP                   0.2359745              0.2137791                0.00000 #> GZMB                  0.0000000              0.0000000                0.00000 #> TSC2                  0.0000000              0.0000000                0.00000 #>          X29_Y-103..Endothelial X24_Y-104..Endothelial X74_Y-104..Endothelial #> PDK4                   2.128942               1.105377               1.533691 #> TNFRSF17               0.000000               0.000000               0.000000 #> ICAM3                  0.000000               0.000000               0.000000 #> FAP                    0.000000               0.000000               0.000000 #> GZMB                   0.000000               0.000000               1.004630 #> TSC2                   0.000000               0.000000               0.000000 #>          X77_Y-104..Endothelial X76_Y-105..Endothelial X77_Y-105..Endothelial #> PDK4                  0.9487501               1.097688              0.9147403 #> TNFRSF17              0.0000000               0.000000              0.0000000 #> ICAM3                 0.0000000               0.000000              0.0000000 #> FAP                   0.0000000               0.000000              0.0000000 #> GZMB                  0.0000000               0.000000              0.0000000 #> TSC2                  0.0000000               0.000000              0.0000000 #>          X76_Y-106..Endothelial X74_Y-105..Endothelial X76_Y-107..Endothelial #> PDK4                  0.0000000               3.067383              0.7343170 #> TNFRSF17              0.0000000               0.000000              0.0000000 #> ICAM3                 0.0000000               0.000000              0.0000000 #> FAP                   0.6858322               0.000000              0.6858322 #> GZMB                  0.0000000               0.000000              0.0000000 #> TSC2                  0.0000000               0.000000              0.0000000 #>          X75_Y-107..Endothelial X65_Y-97..Endothelial X67_Y-98..Endothelial #> PDK4                    1.28397              0.000000                     0 #> TNFRSF17                0.00000              0.000000                     0 #> ICAM3                   0.00000              0.000000                     0 #> FAP                     0.00000              1.088931                     0 #> GZMB                    1.28397              0.000000                     0 #> TSC2                    0.00000              0.000000                     0 #>          X66_Y-98..Endothelial X61_Y-99..Endothelial X62_Y-99..Endothelial #> PDK4                         0              0.000000             0.7574019 #> TNFRSF17                     0              0.000000             0.0000000 #> ICAM3                        0              0.000000             0.0000000 #> FAP                          0              4.333204             0.3750924 #> GZMB                         0              0.000000             0.0000000 #> TSC2                         0              0.000000             0.0000000 #>          X62_Y-100..Endothelial X64_Y-100..Endothelial X63_Y-100..Endothelial #> PDK4                  0.7505041               1.147905              0.7851413 #> TNFRSF17              0.0000000               0.000000              0.0000000 #> ICAM3                 0.0000000               0.000000              0.0000000 #> FAP                   0.2411308               0.000000              0.7610388 #> GZMB                  0.2318682               0.000000              0.3606839 #> TSC2                  0.0000000               0.000000              0.0000000 #>          X66_Y-100..Endothelial X65_Y-101..Endothelial X65_Y-102..Endothelial #> PDK4                          0              1.1598654                      0 #> TNFRSF17                      0              0.0000000                      0 #> ICAM3                         0              0.0000000                      0 #> FAP                           0              0.0000000                      0 #> GZMB                          0              0.3067167                      0 #> TSC2                          0              0.0000000                      0 #>          X66_Y-102..Endothelial X66_Y-103..Endothelial X64_Y-103..Endothelial #> PDK4                  0.9995219                      0                      0 #> TNFRSF17              0.0000000                      0                      0 #> ICAM3                 0.0000000                      0                      0 #> FAP                   0.0000000                      0                      0 #> GZMB                  0.6066330                      0                      0 #> TSC2                  0.0000000                      0                      0 #>          X64_Y-101..Endothelial X67_Y-102..Endothelial X66_Y-104..Endothelial #> PDK4                   1.742543              0.0000000              0.4221172 #> TNFRSF17               0.000000              0.0000000              0.0000000 #> ICAM3                  0.000000              0.0000000              0.0000000 #> FAP                    0.000000              0.4809264              0.0000000 #> GZMB                   0.000000              0.9560357              0.7002576 #> TSC2                   0.000000              0.0000000              0.0000000 #>          X22_Y-107..Endothelial X67_Y-86..Endothelial X68_Y-86..Endothelial #> PDK4                          0                     0                     0 #> TNFRSF17                      0                     0                     0 #> ICAM3                         0                     0                     0 #> FAP                           0                     0                     0 #> GZMB                          0                     0                     0 #> TSC2                          0                     0                     0 #>          X68_Y-87..Endothelial X69_Y-87..Endothelial X67_Y-87..Endothelial #> PDK4                 0.5160341             0.3416151             0.3856785 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.0000000             0.3639847 #> GZMB                 0.3157206             0.0000000             0.0000000 #> TSC2                 0.0000000             0.4038845             0.3639847 #>          X68_Y-88..Endothelial X68_Y-89..Endothelial X67_Y-89..Endothelial #> PDK4                 0.7794684                     0             0.3481473 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.0000000                     0             0.6317782 #> GZMB                 0.9471617                     0             0.0000000 #> TSC2                 0.9476900                     0             0.0000000 #>          X68_Y-90..Endothelial X25_Y-104..Endothelial X28_Y-104..Endothelial #> PDK4                         0               1.036291              1.0468835 #> TNFRSF17                     0               0.000000              0.0000000 #> ICAM3                        0               0.000000              0.0000000 #> FAP                          0               0.000000              0.3371065 #> GZMB                         0               0.000000              0.2401635 #> TSC2                         0               0.000000              0.3064051 #>          X28_Y-105..Endothelial X29_Y-105..Endothelial X25_Y-105..Endothelial #> PDK4                  1.2778628              1.0531984              0.9473931 #> TNFRSF17              0.0000000              0.0000000              0.0000000 #> ICAM3                 0.0000000              0.0000000              0.0000000 #> FAP                   0.2064564              0.3559807              0.0000000 #> GZMB                  0.2586376              0.0000000              0.3358416 #> TSC2                  0.3299747              0.0000000              0.3412198 #>          X26_Y-105..Endothelial X24_Y-105..Endothelial X24_Y-106..Endothelial #> PDK4                  1.5038988              0.7537624              0.5895344 #> TNFRSF17              0.0000000              0.0000000              0.0000000 #> ICAM3                 0.0000000              0.0000000              0.0000000 #> FAP                   0.4365748              0.3492905              0.4640758 #> GZMB                  0.0000000              0.1847129              0.0000000 #> TSC2                  0.4365748              0.1876709              0.0000000 #>          X27_Y-106..Endothelial X26_Y-106..Endothelial X30_Y-106..Endothelial #> PDK4                  1.6508360              0.6194921              0.6697434 #> TNFRSF17              0.0000000              0.0000000              0.0000000 #> ICAM3                 0.0000000              0.0000000              0.0000000 #> FAP                   0.2664608              0.0000000              0.4838945 #> GZMB                  0.0000000              0.6194921              0.1614845 #> TSC2                  0.0000000              0.0000000              0.0000000 #>          X29_Y-106..Endothelial X28_Y-106..Endothelial X26_Y-107..Endothelial #> PDK4                  0.9269665               1.482092              0.3871826 #> TNFRSF17              0.0000000               0.000000              0.0000000 #> ICAM3                 0.0000000               0.000000              0.0000000 #> FAP                   0.1850968               0.000000              0.5293126 #> GZMB                  0.1614845               0.000000              0.3871826 #> TSC2                  0.0000000               0.000000              0.0000000 #>          X30_Y-107..Endothelial X28_Y-107..Endothelial X27_Y-107..Endothelial #> PDK4                  0.5072372              0.9494827              0.8705592 #> TNFRSF17              0.0000000              0.0000000              0.0000000 #> ICAM3                 0.0000000              0.0000000              0.0000000 #> FAP                   0.2078739              0.0000000              0.0000000 #> GZMB                  0.0000000              0.0000000              0.0000000 #> TSC2                  0.0000000              0.0000000              0.0000000 #>          X30_Y-105..Endothelial X69_Y-102..Endothelial X70_Y-103..Endothelial #> PDK4                  0.6645082                      0                      0 #> TNFRSF17              0.0000000                      0                      0 #> ICAM3                 0.0000000                      0                      0 #> FAP                   0.3365396                      0                      0 #> GZMB                  0.2936083                      0                      0 #> TSC2                  0.0000000                      0                      0 #>          X68_Y-98..Endothelial X70_Y-104..Endothelial X67_Y-104..Endothelial #> PDK4                         0              0.5483225               1.266352 #> TNFRSF17                     0              0.0000000               0.000000 #> ICAM3                        0              0.0000000               0.000000 #> FAP                          0              0.0000000               0.000000 #> GZMB                         0              0.0000000               2.100773 #> TSC2                         0              0.0000000               0.000000 #>          X71_Y-105..Endothelial X70_Y-105..Endothelial X72_Y-105..Endothelial #> PDK4                          0              0.8482456              1.4940079 #> TNFRSF17                      0              0.0000000              0.0000000 #> ICAM3                         0              0.0000000              0.0000000 #> FAP                           0              0.0000000              0.0000000 #> GZMB                          0              0.0000000              0.4334352 #> TSC2                          0              0.0000000              0.4872638 #>          X72_Y-106..Endothelial X70_Y-106..Endothelial X68_Y-106..Endothelial #> PDK4                  0.8923421              0.7068714                      0 #> TNFRSF17              0.0000000              0.0000000                      0 #> ICAM3                 0.0000000              0.0000000                      0 #> FAP                   0.0000000              0.9430810                      0 #> GZMB                  0.0000000              0.0000000                      0 #> TSC2                  0.4331234              0.0000000                      0 #>          X72_Y-107..Endothelial X71_Y-107..Endothelial X69_Y-107..Endothelial #> PDK4                   1.206899               0.000000                      0 #> TNFRSF17               0.000000               0.000000                      0 #> ICAM3                  0.000000               0.000000                      0 #> FAP                    0.000000               4.520800                      0 #> GZMB                   0.000000               3.838474                      0 #> TSC2                   0.000000               0.000000                      0 #>          X70_Y-107..Endothelial X73_Y-107..Endothelial X59_Y-103..Endothelial #> PDK4                   0.000000                      0                      0 #> TNFRSF17               0.000000                      0                      0 #> ICAM3                  0.000000                      0                      0 #> FAP                    2.260400                      0                      0 #> GZMB                   1.919237                      0                      0 #> TSC2                   0.000000                      0                      0 #>          X56_Y-104..Endothelial X59_Y-104..Endothelial X58_Y-104..Endothelial #> PDK4                  0.0000000              0.3882318              0.0000000 #> TNFRSF17              0.0000000              0.0000000              0.0000000 #> ICAM3                 0.0000000              0.0000000              0.0000000 #> FAP                   0.1595378              0.5726165              0.8614058 #> GZMB                  0.0000000              0.5177491              1.1062589 #> TSC2                  0.3584031              0.0000000              0.6011497 #>          X58_Y-105..Endothelial X57_Y-105..Endothelial X56_Y-105..Endothelial #> PDK4                  0.4984146              0.4063066              0.1868640 #> TNFRSF17              0.0000000              0.0000000              0.0000000 #> ICAM3                 0.0000000              0.0000000              0.0000000 #> FAP                   1.2521447              0.1993658              0.1435840 #> GZMB                  0.9679765              0.0000000              0.0000000 #> TSC2                  0.5260060              0.0000000              0.3225628 #>          X55_Y-106..Endothelial X61_Y-106..Endothelial X54_Y-106..Endothelial #> PDK4                  0.6143416                      0              0.4223599 #> TNFRSF17              0.0000000                      0              0.0000000 #> ICAM3                 0.0000000                      0              0.0000000 #> FAP                   0.5635467                      0              0.6159862 #> GZMB                  0.4059497                      0              0.5501480 #> TSC2                  0.0000000                      0              0.0000000 #>          X54_Y-107..Endothelial X57_Y-103..Endothelial X54_Y-104..Endothelial #> PDK4                  1.1576668                      0              0.0000000 #> TNFRSF17              0.0000000                      0              0.0000000 #> ICAM3                 0.0000000                      0              0.0000000 #> FAP                   0.4403962                      0              0.0000000 #> GZMB                  0.9273195                      0              0.6465605 #> TSC2                  0.0000000                      0              0.0000000 #>          X57_Y-104..Endothelial X55_Y-105..Endothelial X64_Y-104..Endothelial #> PDK4                  0.2069407                1.15399              0.4898801 #> TNFRSF17              0.0000000                0.00000              0.0000000 #> ICAM3                 0.0000000                0.00000              0.0000000 #> FAP                   0.1435840                0.00000              0.4898801 #> GZMB                  0.0000000                0.00000              0.0000000 #> TSC2                  0.1776219                0.00000              0.0000000 #>          X65_Y-104..Endothelial X66_Y-106..Endothelial X62_Y-105..Endothelial #> PDK4                    1.71458               0.000000                      0 #> TNFRSF17                0.00000               0.000000                      0 #> ICAM3                   0.00000               0.000000                      0 #> FAP                     1.71458               4.344398                      0 #> GZMB                    0.00000               0.000000                      0 #> TSC2                    0.00000               0.000000                      0 #>          X79_Y-100..Endothelial X53_Y-104..Endothelial X50_Y-104..Endothelial #> PDK4                          0                      0              0.7337304 #> TNFRSF17                      0                      0              0.0000000 #> ICAM3                         0                      0              0.0000000 #> FAP                           0                      0              0.5039680 #> GZMB                          0                      0              0.5039680 #> TSC2                          0                      0              0.0000000 #>          X52_Y-105..Endothelial X54_Y-105..Endothelial X53_Y-105..Endothelial #> PDK4                   0.000000               1.248438               1.872657 #> TNFRSF17               0.000000               0.000000               0.000000 #> ICAM3                  0.000000               0.000000               0.000000 #> FAP                    0.000000               0.000000               0.000000 #> GZMB                   3.440786               0.000000               0.000000 #> TSC2                   0.000000               0.000000               0.000000 #>          X53_Y-106..Endothelial X53_Y-107..Endothelial X33_Y-104..Endothelial #> PDK4                  1.7485848               1.249402              0.6429765 #> TNFRSF17              0.0000000               0.000000              0.0000000 #> ICAM3                 0.0000000               0.000000              0.0000000 #> FAP                   0.6779147               0.000000              0.3027885 #> GZMB                  0.0000000               0.000000              0.0000000 #> TSC2                  0.0000000               0.000000              0.0000000 #>          X32_Y-104..Endothelial X33_Y-105..Endothelial X34_Y-105..Endothelial #> PDK4                  1.6013119              1.1450889              1.5412348 #> TNFRSF17              0.0000000              0.0000000              0.0000000 #> ICAM3                 0.0000000              0.0000000              0.0000000 #> FAP                   0.6621607              0.3307143              0.2335853 #> GZMB                  0.0000000              0.0000000              0.0000000 #> TSC2                  0.0000000              0.0000000              0.0000000 #>          X35_Y-105..Endothelial X32_Y-105..Endothelial X35_Y-106..Endothelial #> PDK4                   2.817623               3.214642              1.0664769 #> TNFRSF17               0.000000               0.000000              0.0000000 #> ICAM3                  0.000000               0.000000              0.0000000 #> FAP                    0.000000               1.612857              0.2269014 #> GZMB                   0.000000               0.000000              0.1884807 #> TSC2                   0.000000               0.000000              0.0000000 #>          X35_Y-107..Endothelial X34_Y-107..Endothelial X33_Y-107..Endothelial #> PDK4                  0.8393564              0.4952121                      0 #> TNFRSF17              0.0000000              0.0000000                      0 #> ICAM3                 0.0000000              0.0000000                      0 #> FAP                   0.4046942              0.4254400                      0 #> GZMB                  0.1919742              0.0000000                      0 #> TSC2                  0.0000000              0.0000000                      0 #>          X34_Y-106..Endothelial X45_Y-104..Endothelial X42_Y-106..Endothelial #> PDK4                  0.9469626               1.653732               3.741288 #> TNFRSF17              0.0000000               0.000000               0.000000 #> ICAM3                 0.0000000               0.000000               0.000000 #> FAP                   0.2618093               1.653732               0.000000 #> GZMB                  0.2174777               0.000000               0.000000 #> TSC2                  0.0000000               1.983383               0.000000 #>          X46_Y-106..Endothelial X43_Y-106..Endothelial X44_Y-106..Endothelial #> PDK4                          0              0.9562075              0.9562075 #> TNFRSF17                      0              0.0000000              0.0000000 #> ICAM3                         0              0.0000000              0.0000000 #> FAP                           0              0.0000000              0.0000000 #> GZMB                          0              0.4404911              0.4404911 #> TSC2                          0              0.5974709              0.5974709 #>          X44_Y-107..Endothelial X46_Y-107..Endothelial X60_Y-99..Endothelial #> PDK4                  1.1155754                      0               1.52802 #> TNFRSF17              0.0000000                      0               0.00000 #> ICAM3                 0.0000000                      0               0.00000 #> FAP                   0.0000000                      0               0.00000 #> GZMB                  0.5139063                      0               0.00000 #> TSC2                  0.6970494                      0               0.00000 #>          X55_Y-99..Endothelial X54_Y-99..Endothelial X59_Y-101..Endothelial #> PDK4                 0.8990608                     0              1.0990235 #> TNFRSF17             0.0000000                     0              0.0000000 #> ICAM3                0.0000000                     0              0.0000000 #> FAP                  0.0000000                     0              0.4765399 #> GZMB                 0.0000000                     0              0.0000000 #> TSC2                 0.0000000                     0              1.5020588 #>          X58_Y-101..Endothelial X55_Y-102..Endothelial X57_Y-102..Endothelial #> PDK4                  1.2821940                      0              0.0000000 #> TNFRSF17              0.0000000                      0              0.0000000 #> ICAM3                 0.0000000                      0              0.0000000 #> FAP                   0.5559632                      0              0.0000000 #> GZMB                  0.0000000                      0              0.0000000 #> TSC2                  1.7524019                      0              0.8711444 #>          X56_Y-102..Endothelial X56_Y-103..Endothelial X39_Y-97..Endothelial #> PDK4                  0.4719490               1.573163             0.9525105 #> TNFRSF17              0.0000000               0.000000             0.0000000 #> ICAM3                 0.0000000               0.000000             0.0000000 #> FAP                   0.0000000               0.000000             0.0000000 #> GZMB                  0.0000000               0.000000             0.0000000 #> TSC2                  0.4355722               0.000000             0.1779523 #>          X37_Y-97..Endothelial X40_Y-97..Endothelial X37_Y-98..Endothelial #> PDK4                 1.3646833             0.4680505             2.7691433 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.4264808             0.0000000             0.9179353 #> GZMB                 0.2260297             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X39_Y-98..Endothelial X40_Y-98..Endothelial X38_Y-98..Endothelial #> PDK4                 0.1956208              1.800019             0.4221011 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.1515643              0.000000             0.5317270 #> GZMB                 0.2450162              0.000000             0.4185410 #> TSC2                 0.1597685              0.000000             0.1597685 #>          X38_Y-99..Endothelial X39_Y-99..Endothelial X40_Y-99..Endothelial #> PDK4                 0.8615243             0.4958189             0.6117898 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.5941652             0.2411473             0.3235595 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X37_Y-99..Endothelial X39_Y-100..Endothelial X38_Y-100..Endothelial #> PDK4                 1.6704177               1.494714              1.0115168 #> TNFRSF17             0.0000000               0.000000              0.0000000 #> ICAM3                0.0000000               0.000000              0.0000000 #> FAP                  0.8176509               0.000000              0.1523215 #> GZMB                 0.0000000               0.000000              0.0000000 #> TSC2                 0.0000000               0.000000              0.0000000 #>          X40_Y-100..Endothelial X42_Y-100..Endothelial X41_Y-100..Endothelial #> PDK4                  0.2831146                      0              0.3451083 #> TNFRSF17              0.0000000                      0              0.0000000 #> ICAM3                 0.0000000                      0              0.0000000 #> FAP                   0.5449065                      0              0.0000000 #> GZMB                  0.0000000                      0              0.1493658 #> TSC2                  0.0000000                      0              0.0000000 #>          X38_Y-101..Endothelial X39_Y-101..Endothelial X41_Y-101..Endothelial #> PDK4                  1.1814993              0.8892527              0.5751805 #> TNFRSF17              0.0000000              0.0000000              0.0000000 #> ICAM3                 0.0000000              0.0000000              0.0000000 #> FAP                   0.6771758              0.5184961              0.0000000 #> GZMB                  0.0000000              0.0000000              0.2489430 #> TSC2                  0.0000000              0.0000000              0.0000000 #>          X42_Y-103..Endothelial X38_Y-97..Endothelial X42_Y-98..Endothelial #> PDK4                   2.094335             0.6391682             0.0000000 #> TNFRSF17               0.000000             0.0000000             0.0000000 #> ICAM3                  0.000000             0.0000000             0.0000000 #> FAP                    1.755288             0.3364709             0.4353406 #> GZMB                   0.000000             0.1696720             0.0000000 #> TSC2                   0.000000             0.0000000             0.0000000 #>          X41_Y-102..Endothelial X65_Y-85..Endothelial X62_Y-85..Endothelial #> PDK4                          0              1.656274                     0 #> TNFRSF17                      0              0.000000                     0 #> ICAM3                         0              0.000000                     0 #> FAP                           0              0.000000                     0 #> GZMB                          0              0.000000                     0 #> TSC2                          0              0.000000                     0 #>          X62_Y-86..Endothelial X64_Y-86..Endothelial X65_Y-86..Endothelial #> PDK4                 0.0000000             0.8065841             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.6301272             0.0000000             0.0000000 #> GZMB                 0.2719883             0.9983597             0.9265527 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X63_Y-86..Endothelial X60_Y-86..Endothelial X62_Y-87..Endothelial #> PDK4                 0.9388408              0.000000             0.0000000 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.5920186              0.000000             0.0000000 #> GZMB                 0.0000000              1.475526             0.7615673 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X61_Y-87..Endothelial X63_Y-87..Endothelial X63_Y-88..Endothelial #> PDK4                         0             1.1270575             0.0000000 #> TNFRSF17                     0             0.0000000             0.0000000 #> ICAM3                        0             0.0000000             0.0000000 #> FAP                          0             0.0000000             0.9363286 #> GZMB                         0             0.3038826             0.7597065 #> TSC2                         0             0.0000000             0.0000000 #>          X64_Y-88..Endothelial X64_Y-89..Endothelial X61_Y-89..Endothelial #> PDK4                  1.406274              1.129858              0.975044 #> TNFRSF17              0.000000              0.000000              0.000000 #> ICAM3                 0.000000              0.000000              0.000000 #> FAP                   0.000000              1.129858              1.123464 #> GZMB                  0.000000              0.000000              0.000000 #> TSC2                  0.000000              0.000000              0.000000 #>          X66_Y-89..Endothelial X63_Y-89..Endothelial X60_Y-90..Endothelial #> PDK4                         0                     0              0.000000 #> TNFRSF17                     0                     0              0.000000 #> ICAM3                        0                     0              0.000000 #> FAP                          0                     0              1.000756 #> GZMB                         0                     0              0.000000 #> TSC2                         0                     0              0.000000 #>          X62_Y-90..Endothelial X65_Y-90..Endothelial X63_Y-90..Endothelial #> PDK4                  2.925132             0.5477196                     0 #> TNFRSF17              0.000000             0.0000000                     0 #> ICAM3                 0.000000             0.0000000                     0 #> FAP                   0.000000             0.0000000                     0 #> GZMB                  0.000000             0.0000000                     0 #> TSC2                  0.000000             0.0000000                     0 #>          X64_Y-90..Endothelial X62_Y-91..Endothelial X62_Y-89..Endothelial #> PDK4                 1.3250339              0.000000                     0 #> TNFRSF17             0.0000000              0.000000                     0 #> ICAM3                0.0000000              0.000000                     0 #> FAP                  0.3681734              1.935062                     0 #> GZMB                 1.0544812              0.000000                     0 #> TSC2                 0.0000000              0.000000                     0 #>          X64_Y-91..Endothelial X38_Y-91..Endothelial X39_Y-92..Endothelial #> PDK4                 0.9666049             0.5172763             1.2155913 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.4207695             0.2957626             0.7490070 #> GZMB                 1.2051214             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.3971863 #>          X40_Y-92..Endothelial X36_Y-93..Endothelial X39_Y-93..Endothelial #> PDK4                 0.2178568             1.1266113             1.0722352 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.3895993             0.6216184 #> GZMB                 0.0000000             0.0000000             0.1745932 #> TSC2                 0.0000000             0.2004158             0.0000000 #>          X40_Y-93..Endothelial X38_Y-93..Endothelial X37_Y-93..Endothelial #> PDK4                 0.3545521              1.418861             0.4517058 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.1503602              0.220657             0.5553808 #> GZMB                 0.0000000              0.000000             0.0000000 #> TSC2                 0.1620710              0.000000             0.0000000 #>          X40_Y-94..Endothelial X36_Y-94..Endothelial X38_Y-94..Endothelial #> PDK4                 0.6195664             0.9406391             0.9222596 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.3895993             0.1434270 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.2004158             0.2110592 #>          X39_Y-94..Endothelial X37_Y-94..Endothelial X40_Y-95..Endothelial #> PDK4                 0.8926713             0.8175434             0.8900997 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.3170662             0.0000000             0.7442852 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.2004158             0.1973346 #>          X36_Y-95..Endothelial X39_Y-95..Endothelial X37_Y-95..Endothelial #> PDK4                  1.649686                     0             1.5397069 #> TNFRSF17              0.000000                     0             0.0000000 #> ICAM3                 0.000000                     0             0.0000000 #> FAP                   0.000000                     0             0.0000000 #> GZMB                  0.000000                     0             0.0000000 #> TSC2                  0.000000                     0             0.2243321 #>          X38_Y-95..Endothelial X38_Y-96..Endothelial X37_Y-96..Endothelial #> PDK4                 0.7514488             0.8668514             1.2782097 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.2854844             0.9569564 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.6047621 #>          X41_Y-96..Endothelial X40_Y-96..Endothelial X39_Y-96..Endothelial #> PDK4                 1.7582626             1.0023142             1.1275784 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.4966501             0.5391215             0.1604389 #> GZMB                 0.0000000             0.0000000             0.2044219 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X41_Y-94..Endothelial X38_Y-104..Endothelial X41_Y-104..Endothelial #> PDK4                 0.2991142               1.252499              0.9403977 #> TNFRSF17             0.0000000               0.000000              0.0000000 #> ICAM3                0.0000000               0.000000              0.0000000 #> FAP                  0.2506004               1.252499              0.9403977 #> GZMB                 0.0000000               0.000000              0.0000000 #> TSC2                 0.0000000               0.000000              0.0000000 #>          X40_Y-104..Endothelial X40_Y-105..Endothelial X38_Y-105..Endothelial #> PDK4                   1.253864                      0                 1.4115 #> TNFRSF17               0.000000                      0                 0.0000 #> ICAM3                  0.000000                      0                 0.0000 #> FAP                    1.253864                      0                 0.0000 #> GZMB                   0.000000                      0                 0.0000 #> TSC2                   0.000000                      0                 0.0000 #>          X37_Y-105..Endothelial X41_Y-105..Endothelial X37_Y-106..Endothelial #> PDK4                   3.069628               2.579415              1.4365625 #> TNFRSF17               0.000000               0.000000              0.0000000 #> ICAM3                  0.000000               0.000000              0.0000000 #> FAP                    0.000000               0.000000              0.5019920 #> GZMB                   0.000000               1.273616              0.1960712 #> TSC2                   0.000000               0.000000              0.0000000 #>          X38_Y-106..Endothelial X37_Y-107..Endothelial X41_Y-107..Endothelial #> PDK4                  1.0343460              1.1715585               2.473003 #> TNFRSF17              0.0000000              0.0000000               0.000000 #> ICAM3                 0.0000000              0.0000000               0.000000 #> FAP                   0.6431575              0.5610499               0.000000 #> GZMB                  0.3386684              0.2191383               0.000000 #> TSC2                  0.0000000              0.0000000               0.000000 #>          X38_Y-107..Endothelial X52_Y-86..Endothelial X53_Y-86..Endothelial #> PDK4                          0             0.7192486             0.8990608 #> TNFRSF17                      0             0.0000000             0.0000000 #> ICAM3                         0             0.0000000             0.0000000 #> FAP                           0             0.0000000             0.0000000 #> GZMB                          0             0.0000000             0.0000000 #> TSC2                          0             0.0000000             0.0000000 #>          X51_Y-86..Endothelial X55_Y-87..Endothelial X51_Y-87..Endothelial #> PDK4                   2.87698             0.4900467             1.3931292 #> TNFRSF17               0.00000             0.0000000             0.0000000 #> ICAM3                  0.00000             0.0000000             0.0000000 #> FAP                    0.00000             0.0000000             0.0000000 #> GZMB                   0.00000             0.5512442             0.0000000 #> TSC2                   0.00000             0.0000000             0.7985048 #>          X52_Y-88..Endothelial X51_Y-88..Endothelial X53_Y-89..Endothelial #> PDK4                 1.3931292              0.998131              0.000000 #> TNFRSF17             0.0000000              0.000000              0.000000 #> ICAM3                0.0000000              0.000000              0.000000 #> FAP                  0.0000000              0.000000              0.000000 #> GZMB                 0.0000000              0.000000              1.398362 #> TSC2                 0.7985048              0.998131              0.000000 #>          X49_Y-90..Endothelial X54_Y-90..Endothelial X52_Y-90..Endothelial #> PDK4                  1.177629             0.7313855             0.0000000 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             1.1510800             0.0000000 #> GZMB                  0.000000             0.3168300             0.0000000 #> TSC2                  0.000000             0.4011267             0.7820633 #>          X50_Y-90..Endothelial X53_Y-90..Endothelial X51_Y-91..Endothelial #> PDK4                  1.177629              0.000000              3.198127 #> TNFRSF17              0.000000              0.000000              0.000000 #> ICAM3                 0.000000              0.000000              0.000000 #> FAP                   1.161903              0.000000              0.000000 #> GZMB                  0.000000              1.048772              0.000000 #> TSC2                  0.000000              0.000000              0.000000 #>          X52_Y-91..Endothelial X49_Y-88..Endothelial X55_Y-85..Endothelial #> PDK4                 0.6277785                     0              1.716027 #> TNFRSF17             0.0000000                     0              0.000000 #> ICAM3                0.0000000                     0              0.000000 #> FAP                  0.5681410                     0              0.000000 #> GZMB                 0.4069144                     0              0.000000 #> TSC2                 0.0000000                     0              0.000000 #>          X58_Y-86..Endothelial X59_Y-86..Endothelial X54_Y-87..Endothelial #> PDK4                         0                     0               0.73507 #> TNFRSF17                     0                     0               0.00000 #> ICAM3                        0                     0               0.00000 #> FAP                          0                     0               0.00000 #> GZMB                         0                     0               0.00000 #> TSC2                         0                     0               0.00000 #>          X56_Y-87..Endothelial X55_Y-88..Endothelial X59_Y-88..Endothelial #> PDK4                  2.561312             0.0000000                     0 #> TNFRSF17              0.000000             0.0000000                     0 #> ICAM3                 0.000000             0.0000000                     0 #> FAP                   0.000000             0.0000000                     0 #> GZMB                  0.000000             0.4724950                     0 #> TSC2                  0.000000             0.6244327                     0 #>          X59_Y-89..Endothelial X57_Y-89..Endothelial X58_Y-89..Endothelial #> PDK4                         0             0.6269318             0.6269318 #> TNFRSF17                     0             0.0000000             0.0000000 #> ICAM3                        0             0.0000000             0.0000000 #> FAP                          0             0.0000000             0.0000000 #> GZMB                         0             0.0000000             0.0000000 #> TSC2                         0             0.0000000             0.0000000 #>          X56_Y-89..Endothelial X56_Y-90..Endothelial X61_Y-90..Endothelial #> PDK4                         0                     0              0.000000 #> TNFRSF17                     0                     0              0.000000 #> ICAM3                        0                     0              0.000000 #> FAP                          0                     0              1.000756 #> GZMB                         0                     0              0.000000 #> TSC2                         0                     0              0.000000 #>          X58_Y-91..Endothelial X60_Y-91..Endothelial X55_Y-89..Endothelial #> PDK4                  3.565702              1.329106                     0 #> TNFRSF17              0.000000              0.000000                     0 #> ICAM3                 0.000000              0.000000                     0 #> FAP                   0.000000              0.000000                     0 #> GZMB                  0.000000              0.000000                     0 #> TSC2                  3.565702              0.000000                     0 #>          X54_Y-64..Endothelial X55_Y-66..Endothelial X56_Y-66..Endothelial #> PDK4                 0.5930057               1.33232             0.6119309 #> TNFRSF17             0.0000000               0.00000             0.0000000 #> ICAM3                0.0000000               0.00000             0.0000000 #> FAP                  0.0000000               0.00000             0.0000000 #> GZMB                 0.0000000               0.00000             0.5644681 #> TSC2                 0.5192801               0.00000             0.0000000 #>          X56_Y-65..Endothelial X70_Y-64..Endothelial X72_Y-65..Endothelial #> PDK4                  1.191924                     0             0.3030154 #> TNFRSF17              0.000000                     0             0.0000000 #> ICAM3                 0.000000                     0             0.0000000 #> FAP                   0.000000                     0             0.0000000 #> GZMB                  0.000000                     0             0.7667264 #> TSC2                  0.000000                     0             0.0000000 #>          X49_Y-99..Endothelial X51_Y-99..Endothelial X53_Y-99..Endothelial #> PDK4                         0             0.0000000                     0 #> TNFRSF17                     0             0.0000000                     0 #> ICAM3                        0             0.0000000                     0 #> FAP                          0             0.2373406                     0 #> GZMB                         0             0.0000000                     0 #> TSC2                         0             0.0000000                     0 #>          X52_Y-100..Endothelial X49_Y-100..Endothelial X48_Y-100..Endothelial #> PDK4                  0.5074912               1.184393              0.0000000 #> TNFRSF17              0.0000000               0.000000              0.0000000 #> ICAM3                 0.0000000               0.000000              0.0000000 #> FAP                   0.0000000               1.184393              0.3490025 #> GZMB                  0.0000000               0.000000              0.5819433 #> TSC2                  0.0000000               0.000000              0.0000000 #>          X53_Y-100..Endothelial X52_Y-101..Endothelial X51_Y-101..Endothelial #> PDK4                   1.184146                      0              0.0000000 #> TNFRSF17               0.000000                      0              0.0000000 #> ICAM3                  0.000000                      0              0.0000000 #> FAP                    0.000000                      0              0.6324563 #> GZMB                   0.000000                      0              0.0000000 #> TSC2                   0.000000                      0              0.0000000 #>          X52_Y-103..Endothelial X54_Y-103..Endothelial X50_Y-99..Endothelial #> PDK4                   0.000000                      0              0.000000 #> TNFRSF17               0.000000                      0              0.000000 #> ICAM3                  0.000000                      0              0.000000 #> FAP                    1.682491                      0              0.514238 #> GZMB                   0.000000                      0              0.000000 #> TSC2                   1.682491                      0              0.000000 #>          X51_Y-100..Endothelial X50_Y-100..Endothelial X47_Y-98..Endothelial #> PDK4                  0.0000000              0.9459142                     0 #> TNFRSF17              0.0000000              0.0000000                     0 #> ICAM3                 0.0000000              0.0000000                     0 #> FAP                   0.3085428              0.9459142                     0 #> GZMB                  0.0000000              0.0000000                     0 #> TSC2                  0.0000000              0.0000000                     0 #>          X44_Y-98..Endothelial X43_Y-99..Endothelial X43_Y-100..Endothelial #> PDK4                         0             0.7421974              0.9438961 #> TNFRSF17                     0             0.0000000              0.0000000 #> ICAM3                        0             0.0000000              0.0000000 #> FAP                          0             0.0000000              0.0000000 #> GZMB                         0             0.0000000              0.0000000 #> TSC2                         0             0.0000000              0.0000000 #>          X44_Y-100..Endothelial X46_Y-100..Endothelial X47_Y-100..Endothelial #> PDK4                   1.153651                      0              0.0000000 #> TNFRSF17               0.000000                      0              0.0000000 #> ICAM3                  0.000000                      0              0.0000000 #> FAP                    0.000000                      0              0.3490025 #> GZMB                   0.000000                      0              0.0000000 #> TSC2                   0.000000                      0              0.0000000 #>          X47_Y-101..Endothelial X48_Y-101..Endothelial X42_Y-101..Endothelial #> PDK4                          0               0.000000                      0 #> TNFRSF17                      0               0.000000                      0 #> ICAM3                         0               0.000000                      0 #> FAP                           0               0.000000                      0 #> GZMB                          0               1.163887                      0 #> TSC2                          0               0.000000                      0 #>          X46_Y-102..Endothelial X47_Y-102..Endothelial X44_Y-99..Endothelial #> PDK4                  1.2110288              1.2110288             0.9438961 #> TNFRSF17              0.0000000              0.0000000             0.0000000 #> ICAM3                 0.0000000              0.0000000             0.0000000 #> FAP                   0.0000000              0.0000000             0.0000000 #> GZMB                  0.5744422              0.5744422             0.0000000 #> TSC2                  0.0000000              0.0000000             0.0000000 #>          X42_Y-102..Endothelial X27_Y-91..Fibroblast X28_Y-91..Fibroblast #> PDK4                  0.8377341            0.4690205            0.7758785 #> TNFRSF17              0.0000000            0.0000000            0.0000000 #> ICAM3                 0.0000000            0.0000000            0.0000000 #> FAP                   0.7021152            1.3725327            0.5732353 #> GZMB                  0.0000000            0.0000000            0.0000000 #> TSC2                  0.0000000            0.0000000            0.0000000 #>          X25_Y-91..Fibroblast X24_Y-91..Fibroblast X26_Y-91..Fibroblast #> PDK4                  0.00000             0.000000             0.000000 #> TNFRSF17              0.00000             0.000000             0.000000 #> ICAM3                 0.00000             0.000000             0.000000 #> FAP                   0.63572             1.864123             2.197225 #> GZMB                  0.00000             0.000000             0.000000 #> TSC2                  0.00000             0.000000             0.000000 #>          X27_Y-92..Fibroblast X29_Y-92..Fibroblast X28_Y-92..Fibroblast #> PDK4                0.5071629             1.171116            0.6645528 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 2.5937838             0.000000            1.2200737 #> GZMB                0.5037227             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.0000000 #>          X23_Y-92..Fibroblast X24_Y-93..Fibroblast X26_Y-92..Fibroblast #> PDK4                0.0000000             1.411532                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 0.8994922             1.338280                    0 #> GZMB                0.0000000             0.000000                    0 #> TSC2                0.0000000             0.000000                    0 #>          X28_Y-93..Fibroblast X27_Y-93..Fibroblast X26_Y-93..Fibroblast #> PDK4                0.9032266            0.7262602            0.9866613 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.9044899            1.7883209            0.9596186 #> GZMB                0.0000000            0.4477535            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X30_Y-93..Fibroblast X29_Y-93..Fibroblast X23_Y-93..Fibroblast #> PDK4                1.3066659            0.8397811            0.6186864 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.2771736            0.0000000            1.3382802 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X25_Y-93..Fibroblast X28_Y-94..Fibroblast X30_Y-94..Fibroblast #> PDK4                        0            0.6568920            0.3994954 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.3324332            1.0500234 #> GZMB                        0            0.0000000            0.2671440 #> TSC2                        0            0.0000000            0.0000000 #>          X24_Y-94..Fibroblast X27_Y-94..Fibroblast X29_Y-94..Fibroblast #> PDK4                        0            0.4113680            0.8246360 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.6058897            0.7115480 #> GZMB                        0            0.0000000            0.2938584 #> TSC2                        0            0.0000000            0.0000000 #>          X25_Y-94..Fibroblast X26_Y-95..Fibroblast X24_Y-95..Fibroblast #> PDK4                0.4903299            0.4773087                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.0000000            0.5880101                    0 #> GZMB                0.0000000            0.0000000                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X28_Y-95..Fibroblast X27_Y-95..Fibroblast X30_Y-95..Fibroblast #> PDK4                        0            1.0572410            0.7185323 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            1.1426720            0.5824929 #> GZMB                        0            0.5546619            0.0000000 #> TSC2                        0            0.0000000            0.0000000 #>          X26_Y-96..Fibroblast X24_Y-96..Fibroblast X25_Y-96..Fibroblast #> PDK4                1.1934408            1.5941933                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 1.1800831            0.8786722                    0 #> GZMB                0.6028609            0.0000000                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X24_Y-97..Fibroblast X29_Y-97..Fibroblast X25_Y-97..Fibroblast #> PDK4                1.1438588            0.0000000            0.8723152 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.2409568            0.8595345            1.2402291 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X23_Y-97..Fibroblast X26_Y-98..Fibroblast X27_Y-98..Fibroblast #> PDK4                0.8581254             1.060324                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 0.9555936             1.400502                    0 #> GZMB                0.0000000             0.000000                    0 #> TSC2                0.0000000             0.000000                    0 #>          X25_Y-92..Fibroblast X24_Y-92..Fibroblast X25_Y-95..Fibroblast #> PDK4                 0.000000             1.982114            0.7354948 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  1.279491             0.000000            0.0000000 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X27_Y-96..Fibroblast X29_Y-96..Fibroblast X26_Y-97..Fibroblast #> PDK4                0.6959188                    0            1.0370591 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 1.4672574                    0            1.5300209 #> GZMB                0.6655943                    0            0.5167379 #> TSC2                0.0000000                    0            0.0000000 #>          X28_Y-97..Fibroblast X62_Y-91..Fibroblast X65_Y-92..Fibroblast #> PDK4                        0            0.7625637                    0 #> TNFRSF17                    0            0.0000000                    0 #> ICAM3                       0            0.0000000                    0 #> FAP                         0            0.8460130                    0 #> GZMB                        0            1.0706502                    0 #> TSC2                        0            0.0000000                    0 #>          X64_Y-92..Fibroblast X61_Y-92..Fibroblast X65_Y-93..Fibroblast #> PDK4                        0             0.000000            0.0000000 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             2.807459            0.7606549 #> GZMB                        0             1.123547            0.0000000 #> TSC2                        0             0.000000            0.0000000 #>          X66_Y-93..Fibroblast X61_Y-93..Fibroblast X62_Y-94..Fibroblast #> PDK4                        0             0.000000            0.8328684 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             1.705995            0.0000000 #> GZMB                        0             0.000000            0.0000000 #> TSC2                        0             0.000000            0.0000000 #>          X63_Y-94..Fibroblast X65_Y-94..Fibroblast X66_Y-94..Fibroblast #> PDK4                0.3018114                    0             0.000000 #> TNFRSF17            0.0000000                    0             0.000000 #> ICAM3               0.0000000                    0             0.000000 #> FAP                 0.3029910                    0             1.365733 #> GZMB                0.0000000                    0             0.000000 #> TSC2                0.0000000                    0             0.000000 #>          X61_Y-94..Fibroblast X64_Y-94..Fibroblast X62_Y-95..Fibroblast #> PDK4                 0.000000                    0            0.2263585 #> TNFRSF17             0.000000                    0            0.0000000 #> ICAM3                0.000000                    0            0.0000000 #> FAP                  1.773711                    0            0.6163538 #> GZMB                 0.000000                    0            0.0000000 #> TSC2                 0.000000                    0            0.0000000 #>          X63_Y-95..Fibroblast X65_Y-95..Fibroblast X64_Y-95..Fibroblast #> PDK4                0.2716302             0.000000                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 0.3449600             1.085262                    0 #> GZMB                0.4008316             0.000000                    0 #> TSC2                0.0000000             0.000000                    0 #>          X66_Y-95..Fibroblast X61_Y-95..Fibroblast X60_Y-95..Fibroblast #> PDK4                 0.000000            0.3961696            0.7898948 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.279202            0.3181991            0.6511375 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X67_Y-95..Fibroblast X61_Y-96..Fibroblast X62_Y-96..Fibroblast #> PDK4                0.0000000            0.4952121            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.1745012            0.0000000            1.2702909 #> GZMB                0.2034810            1.0231393            0.7222006 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X67_Y-96..Fibroblast X66_Y-96..Fibroblast X63_Y-96..Fibroblast #> PDK4                0.0000000             0.000000            0.6088494 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.6918861             1.214368            1.0156572 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.0000000 #>          X60_Y-96..Fibroblast X61_Y-97..Fibroblast X62_Y-97..Fibroblast #> PDK4                0.0000000            0.2280805            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.6260271            0.4169211            0.4100490 #> GZMB                0.0000000            0.2751365            0.4814671 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X63_Y-97..Fibroblast X60_Y-97..Fibroblast X64_Y-97..Fibroblast #> PDK4                        0            0.5139001                    0 #> TNFRSF17                    0            0.0000000                    0 #> ICAM3                       0            0.0000000                    0 #> FAP                         0            0.5134118                    0 #> GZMB                        0            0.0000000                    0 #> TSC2                        0            0.0000000                    0 #>          X62_Y-98..Fibroblast X62_Y-92..Fibroblast X60_Y-94..Fibroblast #> PDK4                0.3314364            0.0000000             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.3194301            1.7091850             1.601467 #> GZMB                0.0000000            1.7553580             0.000000 #> TSC2                0.0000000            0.6671558             0.000000 #>          X54_Y-91..Fibroblast X56_Y-91..Fibroblast X60_Y-91..Fibroblast #> PDK4                0.8627328            0.4603509            0.7664300 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.7735483            0.2338288            1.7632592 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.9968292 #>          X57_Y-91..Fibroblast X56_Y-92..Fibroblast X55_Y-92..Fibroblast #> PDK4                  0.00000            0.4357487            0.1562593 #> TNFRSF17              0.00000            0.0000000            0.0000000 #> ICAM3                 0.00000            0.0000000            0.0000000 #> FAP                   2.08092            0.4390914            1.2628491 #> GZMB                  0.00000            0.0000000            0.0000000 #> TSC2                  0.00000            0.0000000            0.0000000 #>          X54_Y-92..Fibroblast X58_Y-92..Fibroblast X57_Y-92..Fibroblast #> PDK4                0.0000000             0.000000             0.281404 #> TNFRSF17            0.0000000             0.000000             0.000000 #> ICAM3               0.0000000             0.000000             0.000000 #> FAP                 1.0016055             1.061403             0.000000 #> GZMB                0.2214762             0.000000             0.000000 #> TSC2                0.0000000             0.000000             0.000000 #>          X60_Y-92..Fibroblast X57_Y-93..Fibroblast X56_Y-93..Fibroblast #> PDK4                 0.000000            0.0000000             0.000000 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  1.144018            0.5738042             1.291583 #> GZMB                 0.000000            0.0000000             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X59_Y-93..Fibroblast X55_Y-93..Fibroblast X58_Y-93..Fibroblast #> PDK4                        0             0.000000            0.4676017 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             1.934681            0.8596109 #> GZMB                        0             0.000000            0.0000000 #> TSC2                        0             0.000000            0.0000000 #>          X60_Y-93..Fibroblast X57_Y-94..Fibroblast X58_Y-94..Fibroblast #> PDK4                0.0000000            0.0000000            0.2651659 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.7453124            0.7915595            0.6301798 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X59_Y-94..Fibroblast X55_Y-94..Fibroblast X56_Y-94..Fibroblast #> PDK4                0.3836174            0.9596219                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.4242963            0.5165802                    0 #> GZMB                0.0000000            0.0000000                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X54_Y-94..Fibroblast X54_Y-95..Fibroblast X58_Y-95..Fibroblast #> PDK4                1.4490471            1.5854221            0.4413181 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.4809532            0.6919206            0.4413181 #> GZMB                0.2374912            0.2226480            0.9843379 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X57_Y-95..Fibroblast X59_Y-95..Fibroblast X56_Y-95..Fibroblast #> PDK4                0.5433446            0.0000000            0.6799623 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.9089941            1.3661879            0.2206729 #> GZMB                0.6327887            0.0000000            0.0000000 #> TSC2                0.0000000            0.3282181            0.0000000 #>          X55_Y-95..Fibroblast X59_Y-96..Fibroblast X56_Y-96..Fibroblast #> PDK4                0.5433155             0.000000            0.6538346 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 1.0323111             1.257814            0.6934370 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.2227370             0.000000            0.0000000 #>          X55_Y-96..Fibroblast X58_Y-96..Fibroblast X57_Y-96..Fibroblast #> PDK4                0.1928238            0.7192598            0.4577108 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.5554458            0.5522198            0.6239213 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.2712497 #>          X59_Y-97..Fibroblast X55_Y-97..Fibroblast X57_Y-97..Fibroblast #> PDK4                0.0000000            0.3971863            0.3356546 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.9229653            0.8031651            0.0000000 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.3971863            0.1989165 #>          X54_Y-97..Fibroblast X58_Y-97..Fibroblast X60_Y-98..Fibroblast #> PDK4                 0.000000            0.5869769            0.4063073 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.519413            0.1982082            0.4462566 #> GZMB                 1.519413            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X57_Y-98..Fibroblast X56_Y-97..Fibroblast X59_Y-98..Fibroblast #> PDK4                0.0000000            0.0000000             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.9999605            0.5483143             0.905126 #> GZMB                0.4440807            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.223361 #>          X55_Y-98..Fibroblast X74_Y-97..Fibroblast X75_Y-97..Fibroblast #> PDK4                0.0000000            0.2721114            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.0915618            0.6726096            0.0000000 #> GZMB                0.3386684            0.0000000            0.4605453 #> TSC2                0.0000000            0.2721114            0.0000000 #>          X73_Y-97..Fibroblast X76_Y-97..Fibroblast X75_Y-98..Fibroblast #> PDK4                0.3796169            0.2999922             1.141870 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.4770613            0.6570646             1.326707 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X77_Y-98..Fibroblast X73_Y-98..Fibroblast X78_Y-98..Fibroblast #> PDK4                1.6973220                    0            1.0088059 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.7309858                    0            0.7384907 #> GZMB                0.0000000                    0            0.0000000 #> TSC2                0.0000000                    0            0.0000000 #>          X76_Y-98..Fibroblast X76_Y-99..Fibroblast X75_Y-99..Fibroblast #> PDK4                0.6467944             0.000000            0.3740742 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.9659376             1.122758            1.3426344 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.0000000 #>          X74_Y-99..Fibroblast X77_Y-99..Fibroblast X76_Y-100..Fibroblast #> PDK4                 0.000000                    0             0.0000000 #> TNFRSF17             0.000000                    0             0.0000000 #> ICAM3                0.000000                    0             0.0000000 #> FAP                  1.525671                    0             0.7615673 #> GZMB                 0.000000                    0             0.0000000 #> TSC2                 0.000000                    0             0.0000000 #>          X74_Y-100..Fibroblast X73_Y-100..Fibroblast X75_Y-100..Fibroblast #> PDK4                 0.0000000             0.3613437             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.9189617             0.3817621             0.9104364 #> GZMB                 0.3627947             0.0000000             0.0000000 #> TSC2                 0.0000000             0.4997199             0.0000000 #>          X77_Y-100..Fibroblast X72_Y-100..Fibroblast X78_Y-100..Fibroblast #> PDK4                 0.0000000             0.2627954              0.000000 #> TNFRSF17             0.0000000             0.0000000              0.000000 #> ICAM3                0.0000000             0.0000000              0.000000 #> FAP                  2.9905066             0.2776451              1.748738 #> GZMB                 0.0000000             0.0000000              0.000000 #> TSC2                 0.7178741             0.3634326              0.000000 #>          X74_Y-101..Fibroblast X78_Y-101..Fibroblast X73_Y-101..Fibroblast #> PDK4                  0.000000                     0             0.0000000 #> TNFRSF17              0.000000                     0             0.0000000 #> ICAM3                 0.000000                     0             0.0000000 #> FAP                   1.037089                     0             0.7111473 #> GZMB                  0.000000                     0             0.0000000 #> TSC2                  0.000000                     0             0.0000000 #>          X76_Y-101..Fibroblast X77_Y-101..Fibroblast X78_Y-102..Fibroblast #> PDK4                         0              0.688743                     0 #> TNFRSF17                     0              0.000000                     0 #> ICAM3                        0              0.000000                     0 #> FAP                          0              0.000000                     0 #> GZMB                         0              0.000000                     0 #> TSC2                         0              0.000000                     0 #>          X74_Y-102..Fibroblast X77_Y-102..Fibroblast X75_Y-103..Fibroblast #> PDK4                         0             0.9535679             0.4478184 #> TNFRSF17                     0             0.0000000             0.0000000 #> ICAM3                        0             0.0000000             0.0000000 #> FAP                          0             1.0474308             0.3834590 #> GZMB                         0             0.0000000             0.0000000 #> TSC2                         0             0.0000000             0.0000000 #>          X77_Y-103..Fibroblast X78_Y-103..Fibroblast X74_Y-103..Fibroblast #> PDK4                 0.9574006             0.8285690             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.6173089             0.3609429             0.5495108 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X75_Y-104..Fibroblast X77_Y-104..Fibroblast X74_Y-104..Fibroblast #> PDK4                 0.0000000              0.913731             0.0000000 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.8364593              2.048370             0.8816144 #> GZMB                 0.0000000              0.000000             0.0000000 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X76_Y-104..Fibroblast X74_Y-98..Fibroblast X72_Y-99..Fibroblast #> PDK4                 0.7611306            0.0000000            0.0000000 #> TNFRSF17             0.0000000            0.0000000            0.0000000 #> ICAM3                0.0000000            0.0000000            0.0000000 #> FAP                  1.6120107            0.9383844            0.7742138 #> GZMB                 0.0000000            0.0000000            0.0000000 #> TSC2                 0.0000000            0.0000000            0.0000000 #>          X73_Y-99..Fibroblast X73_Y-102..Fibroblast X75_Y-102..Fibroblast #> PDK4                        0                     0                     0 #> TNFRSF17                    0                     0                     0 #> ICAM3                       0                     0                     0 #> FAP                         0                     0                     0 #> GZMB                        0                     0                     0 #> TSC2                        0                     0                     0 #>          X76_Y-102..Fibroblast X73_Y-103..Fibroblast X76_Y-103..Fibroblast #> PDK4                  1.300952                     0             0.8956368 #> TNFRSF17              0.000000                     0             0.0000000 #> ICAM3                 0.000000                     0             0.0000000 #> FAP                   1.300952                     0             0.0000000 #> GZMB                  0.000000                     0             0.0000000 #> TSC2                  0.000000                     0             0.0000000 #>          X76_Y-85..Fibroblast X75_Y-85..Fibroblast X74_Y-85..Fibroblast #> PDK4                        0             0.000000            0.0000000 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             1.113367            1.2145823 #> GZMB                        0             0.259995            0.2836309 #> TSC2                        0             0.000000            0.0000000 #>          X73_Y-85..Fibroblast X77_Y-85..Fibroblast X74_Y-86..Fibroblast #> PDK4                        0            0.0000000            0.0000000 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.6700319            0.5688769 #> GZMB                        0            0.0000000            0.0000000 #> TSC2                        0            0.0000000            0.0000000 #>          X73_Y-86..Fibroblast X78_Y-86..Fibroblast X75_Y-86..Fibroblast #> PDK4                0.0000000                    0            0.0000000 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.4977673                    0            0.8038857 #> GZMB                0.0000000                    0            0.0000000 #> TSC2                0.0000000                    0            0.0000000 #>          X76_Y-86..Fibroblast X77_Y-86..Fibroblast X74_Y-87..Fibroblast #> PDK4                0.0000000            0.8133253             1.221356 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.4113262            0.0000000             1.221356 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X73_Y-87..Fibroblast X72_Y-87..Fibroblast X76_Y-87..Fibroblast #> PDK4                 0.000000            0.2808659            0.0000000 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.464718            0.9585520            0.3647169 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X75_Y-87..Fibroblast X78_Y-87..Fibroblast X77_Y-87..Fibroblast #> PDK4                 0.000000             0.000000            0.9077021 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  0.863337             1.272164            0.3299170 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X78_Y-88..Fibroblast X77_Y-88..Fibroblast X75_Y-88..Fibroblast #> PDK4                0.0000000            0.8016631            0.4927100 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.7632981            0.5278672            0.4530305 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X72_Y-88..Fibroblast X76_Y-88..Fibroblast X73_Y-88..Fibroblast #> PDK4                 0.000000             0.788336            0.0000000 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  1.089685             1.568777            0.3259957 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X74_Y-89..Fibroblast X76_Y-89..Fibroblast X73_Y-89..Fibroblast #> PDK4                        0            0.0000000            0.2899662 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            1.1205549            0.3712986 #> GZMB                        0            0.7869986            0.0000000 #> TSC2                        0            0.6190291            0.0000000 #>          X75_Y-89..Fibroblast X78_Y-89..Fibroblast X74_Y-90..Fibroblast #> PDK4                0.0000000             0.000000            0.0000000 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.0000000             1.944345            0.0000000 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.6190291             0.000000            0.4902589 #>          X75_Y-90..Fibroblast X73_Y-90..Fibroblast X76_Y-90..Fibroblast #> PDK4                 0.000000            0.0000000            0.9793078 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.714482            0.5280041            0.7030943 #> GZMB                 0.000000            0.2309652            0.0000000 #> TSC2                 0.000000            0.2614714            0.0000000 #>          X78_Y-90..Fibroblast X77_Y-90..Fibroblast X75_Y-91..Fibroblast #> PDK4                0.0000000            0.6528718            0.5744395 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.7777381            0.0000000            0.8268103 #> GZMB                2.2657116            0.0000000            0.5483225 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X78_Y-91..Fibroblast X77_Y-91..Fibroblast X74_Y-91..Fibroblast #> PDK4                0.0000000             0.000000             0.000000 #> TNFRSF17            0.0000000             0.000000             0.000000 #> ICAM3               0.0000000             0.000000             0.000000 #> FAP                 0.4619123             1.039303             1.511313 #> GZMB                1.2587287             0.000000             0.000000 #> TSC2                0.0000000             0.000000             0.000000 #>          X79_Y-91..Fibroblast X73_Y-91..Fibroblast X72_Y-91..Fibroblast #> PDK4                0.0000000             0.000000            0.0000000 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.8277628             2.357098            0.2534289 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.0000000 #>          X72_Y-86..Fibroblast X77_Y-89..Fibroblast X72_Y-90..Fibroblast #> PDK4                 0.000000            0.6528718            0.0000000 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.074576            0.0000000            0.5451169 #> GZMB                 0.000000            0.9181650            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X76_Y-91..Fibroblast X35_Y-72..Fibroblast X30_Y-72..Fibroblast #> PDK4                 0.000000            0.5293999            0.8103472 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.331865            0.9908267            0.0000000 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X35_Y-73..Fibroblast X30_Y-74..Fibroblast X32_Y-74..Fibroblast #> PDK4                1.2175479                    0            0.5974709 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.3845169                    0            1.1311013 #> GZMB                0.0000000                    0            0.0000000 #> TSC2                0.0000000                    0            0.0000000 #>          X33_Y-74..Fibroblast X32_Y-75..Fibroblast X33_Y-75..Fibroblast #> PDK4                        0            0.5227870            0.6970494 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.9765159            0.0000000 #> GZMB                        0            0.0000000            0.0000000 #> TSC2                        0            0.0000000            0.0000000 #>          X30_Y-75..Fibroblast X34_Y-76..Fibroblast X32_Y-77..Fibroblast #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X33_Y-77..Fibroblast X35_Y-78..Fibroblast X29_Y-78..Fibroblast #> PDK4                 2.663536            0.6636118                    0 #> TNFRSF17             0.000000            0.0000000                    0 #> ICAM3                0.000000            0.0000000                    0 #> FAP                  0.000000            0.0000000                    0 #> GZMB                 0.000000            0.0000000                    0 #> TSC2                 0.000000            0.0000000                    0 #>          X34_Y-78..Fibroblast X32_Y-78..Fibroblast X31_Y-78..Fibroblast #> PDK4                0.0000000                    0             1.402683 #> TNFRSF17            0.0000000                    0             0.000000 #> ICAM3               0.0000000                    0             0.000000 #> FAP                 0.8845006                    0             1.402683 #> GZMB                0.0000000                    0             0.000000 #> TSC2                0.0000000                    0             0.000000 #>          X30_Y-79..Fibroblast X32_Y-79..Fibroblast X33_Y-73..Fibroblast #> PDK4                 2.069451                    0            0.5327587 #> TNFRSF17             0.000000                    0            0.0000000 #> ICAM3                0.000000                    0            0.0000000 #> FAP                  0.000000                    0            0.0000000 #> GZMB                 0.000000                    0            0.0000000 #> TSC2                 0.000000                    0            0.0000000 #>          X34_Y-73..Fibroblast X31_Y-73..Fibroblast X36_Y-73..Fibroblast #> PDK4                0.0000000                    0            1.1417063 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.5700893                    0            0.7518012 #> GZMB                0.0000000                    0            0.0000000 #> TSC2                0.0000000                    0            0.0000000 #>          X32_Y-73..Fibroblast X30_Y-73..Fibroblast X36_Y-74..Fibroblast #> PDK4                        0               1.3533            0.5373701 #> TNFRSF17                    0               0.0000            0.0000000 #> ICAM3                       0               0.0000            0.0000000 #> FAP                         0               0.0000            0.0000000 #> GZMB                        0               0.0000            0.0000000 #> TSC2                        0               0.0000            0.0000000 #>          X34_Y-74..Fibroblast X35_Y-74..Fibroblast X31_Y-74..Fibroblast #> PDK4                0.0000000            0.7805710              0.00000 #> TNFRSF17            0.0000000            0.0000000              0.00000 #> ICAM3               0.0000000            0.0000000              0.00000 #> FAP                 0.7474558            0.7690338              1.76163 #> GZMB                0.0000000            0.0000000              0.00000 #> TSC2                0.0000000            0.0000000              0.00000 #>          X34_Y-75..Fibroblast X35_Y-75..Fibroblast X35_Y-76..Fibroblast #> PDK4                0.0000000            0.6898024            0.5888143 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.7474558            0.7643098            0.0000000 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X31_Y-76..Fibroblast X33_Y-76..Fibroblast X32_Y-76..Fibroblast #> PDK4                0.0000000                    0             0.000000 #> TNFRSF17            0.0000000                    0             0.000000 #> ICAM3               0.0000000                    0             0.000000 #> FAP                 0.5993738                    0             0.513749 #> GZMB                0.0000000                    0             0.000000 #> TSC2                0.0000000                    0             0.000000 #>          X35_Y-77..Fibroblast X34_Y-77..Fibroblast X33_Y-78..Fibroblast #> PDK4                 2.767023             0.000000             2.663536 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  0.000000             2.758138             0.000000 #> GZMB                 1.091693             0.000000             0.000000 #> TSC2                 0.000000             0.000000             0.000000 #>          X30_Y-78..Fibroblast X34_Y-79..Fibroblast X38_Y-66..Fibroblast #> PDK4                 2.891805             1.657803            0.7985048 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  0.000000             0.000000            0.7118093 #> GZMB                 0.000000             0.000000            0.7768031 #> TSC2                 0.000000             0.000000            0.0000000 #>          X42_Y-66..Fibroblast X37_Y-66..Fibroblast X41_Y-66..Fibroblast #> PDK4                0.4605453            0.7985048            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.4605453            0.7118093            0.0000000 #> GZMB                0.0000000            0.7768031            0.0000000 #> TSC2                0.0000000            0.0000000            0.8714273 #>          X39_Y-67..Fibroblast X42_Y-67..Fibroblast X40_Y-67..Fibroblast #> PDK4                0.6867934             1.063543             0.000000 #> TNFRSF17            0.0000000             0.000000             0.000000 #> ICAM3               0.0000000             0.000000             0.000000 #> FAP                 1.2286122             1.159904             2.660317 #> GZMB                0.0000000             0.000000             0.000000 #> TSC2                0.0000000             0.000000             0.000000 #>          X37_Y-67..Fibroblast X41_Y-67..Fibroblast X38_Y-67..Fibroblast #> PDK4                0.9981310            0.5196456             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 1.1370387            0.0000000             2.274077 #> GZMB                0.9710038            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X37_Y-68..Fibroblast X41_Y-68..Fibroblast X39_Y-68..Fibroblast #> PDK4                        0            1.1978671            2.0197100 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.4558930            0.6440826 #> GZMB                        0            0.5127912            0.0000000 #> TSC2                        0            0.0000000            0.0000000 #>          X38_Y-68..Fibroblast X40_Y-68..Fibroblast X36_Y-68..Fibroblast #> PDK4                0.8721954            0.9132741             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.0000000            0.8385641             3.005378 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.8721954            0.0000000             0.000000 #>          X35_Y-68..Fibroblast X42_Y-68..Fibroblast X39_Y-69..Fibroblast #> PDK4                        0             1.126072            0.9324426 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             0.000000            0.0000000 #> GZMB                        0             0.000000            0.5335767 #> TSC2                        0             0.000000            0.0000000 #>          X42_Y-69..Fibroblast X36_Y-69..Fibroblast X38_Y-69..Fibroblast #> PDK4                0.8594967            0.6360818            0.8446870 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.5712218            0.0000000            0.4407518 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X41_Y-69..Fibroblast X40_Y-69..Fibroblast X37_Y-69..Fibroblast #> PDK4                0.8762375            0.5749334             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.9216902            0.5749334             2.042952 #> GZMB                0.5768901            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X38_Y-70..Fibroblast X39_Y-70..Fibroblast X41_Y-70..Fibroblast #> PDK4                 1.032665            0.8263053             0.000000 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  1.398745            0.6890266             1.379708 #> GZMB                 0.000000            0.4742904             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X40_Y-70..Fibroblast X37_Y-70..Fibroblast X42_Y-70..Fibroblast #> PDK4                0.5992261            0.5898931            0.3176795 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.3928732            0.5241849            1.0327700 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X41_Y-71..Fibroblast X37_Y-71..Fibroblast X38_Y-71..Fibroblast #> PDK4                0.9815700            0.7334163                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.6857736            0.3865539                    0 #> GZMB                0.0000000            0.0000000                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X42_Y-71..Fibroblast X39_Y-71..Fibroblast X35_Y-71..Fibroblast #> PDK4                 0.536774            0.0000000             0.000000 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  1.656300            0.4160269             1.610665 #> GZMB                 0.000000            0.0000000             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X36_Y-71..Fibroblast X40_Y-71..Fibroblast X37_Y-72..Fibroblast #> PDK4                 1.011550            0.9346924            2.4313316 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.075992            0.5720370            0.6368415 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X39_Y-72..Fibroblast X36_Y-72..Fibroblast X40_Y-72..Fibroblast #> PDK4                1.3800636            0.6176332            0.4245386 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.7498715            0.0000000            0.3459727 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X38_Y-72..Fibroblast X41_Y-72..Fibroblast X41_Y-73..Fibroblast #> PDK4                0.3849338                    0            0.6246509 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.4686697                    0            1.6202404 #> GZMB                0.0000000                    0            0.0000000 #> TSC2                0.0000000                    0            0.0000000 #>          X40_Y-73..Fibroblast X39_Y-73..Fibroblast X38_Y-73..Fibroblast #> PDK4                0.3966474            0.3421634            0.2719097 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.8436190            1.2134860            0.0000000 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X37_Y-73..Fibroblast X36_Y-70..Fibroblast X42_Y-73..Fibroblast #> PDK4                1.7271793            0.9541226            0.6727009 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.9114501            0.7862774            1.7448743 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X41_Y-74..Fibroblast X40_Y-74..Fibroblast X39_Y-74..Fibroblast #> PDK4                0.6482064            0.3142794            0.8062784 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.6604051            1.4008107            1.6551299 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.4345690            0.2230008 #>          X38_Y-74..Fibroblast X37_Y-74..Fibroblast X39_Y-75..Fibroblast #> PDK4                        0                    0            1.0795430 #> TNFRSF17                    0                    0            0.0000000 #> ICAM3                       0                    0            0.0000000 #> FAP                         0                    0            0.9359458 #> GZMB                        0                    0            0.0000000 #> TSC2                        0                    0            0.0000000 #>          X36_Y-75..Fibroblast X40_Y-75..Fibroblast X38_Y-75..Fibroblast #> PDK4                0.6269318            0.8528679            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            1.2099439            1.4640247 #> GZMB                0.0000000            0.0000000            0.4600590 #> TSC2                0.0000000            0.0000000            0.5321931 #>          X42_Y-75..Fibroblast X41_Y-75..Fibroblast X40_Y-76..Fibroblast #> PDK4                0.7957226              1.29623            0.5254331 #> TNFRSF17            0.0000000              0.00000            0.0000000 #> ICAM3               0.0000000              0.00000            0.0000000 #> FAP                 1.3086876              0.00000            1.5540830 #> GZMB                0.0000000              0.00000            0.3611003 #> TSC2                0.3888691              1.29623            0.0000000 #>          X41_Y-76..Fibroblast X39_Y-76..Fibroblast X36_Y-76..Fibroblast #> PDK4                0.3533089            0.8092005            0.8703865 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 2.9008575            1.9115802            0.8289816 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X37_Y-76..Fibroblast X38_Y-76..Fibroblast X39_Y-77..Fibroblast #> PDK4                0.0000000             0.000000            0.4945816 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.6628311             1.218539            0.4124863 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.0000000 #>          X40_Y-77..Fibroblast X36_Y-77..Fibroblast X41_Y-77..Fibroblast #> PDK4                0.3508843            0.5439916             2.073263 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 1.2585815            0.5398094             2.762419 #> GZMB                0.4814671            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X38_Y-77..Fibroblast X37_Y-77..Fibroblast X42_Y-77..Fibroblast #> PDK4                0.7659193            0.5744395             0.661493 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 1.1308601            0.9123334             0.000000 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X37_Y-78..Fibroblast X41_Y-78..Fibroblast X38_Y-78..Fibroblast #> PDK4                0.3010868            0.7820633             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 2.6994135            1.7854727             1.088931 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X36_Y-78..Fibroblast X40_Y-78..Fibroblast X42_Y-78..Fibroblast #> PDK4                0.3247640            0.6903094            0.5691383 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.7173527            2.9120975            0.0000000 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X38_Y-79..Fibroblast X36_Y-79..Fibroblast X39_Y-79..Fibroblast #> PDK4                 1.130125             1.179938            0.5483458 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  2.312751             1.580627            2.9703442 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X37_Y-79..Fibroblast X37_Y-75..Fibroblast X42_Y-79..Fibroblast #> PDK4                0.4605881            0.0000000            0.6704715 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.7165719            0.7450704            0.2633319 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.2782435            0.7450704            0.3455523 #>          X73_Y-72..Fibroblast X75_Y-73..Fibroblast X76_Y-73..Fibroblast #> PDK4                 0.000000            0.1938161            0.5194187 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.499987            0.8620350            0.2615926 #> GZMB                 0.000000            0.2000420            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X78_Y-73..Fibroblast X77_Y-73..Fibroblast X74_Y-73..Fibroblast #> PDK4                0.6708513            0.0000000                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.5604280            1.2609781                    0 #> GZMB                0.7995518            0.5256183                    0 #> TSC2                0.5604280            0.0000000                    0 #>          X77_Y-74..Fibroblast X75_Y-74..Fibroblast X72_Y-74..Fibroblast #> PDK4                0.1723725            0.2874667            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.6691700            0.4417622            0.0000000 #> GZMB                0.2489771            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.4743751 #>          X74_Y-74..Fibroblast X76_Y-74..Fibroblast X73_Y-74..Fibroblast #> PDK4                0.4957918            0.0000000            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.2827174            0.9081593            0.4782185 #> GZMB                0.0000000            0.3378975            0.0000000 #> TSC2                0.0000000            0.0000000            0.4216667 #>          X78_Y-74..Fibroblast X74_Y-75..Fibroblast X75_Y-75..Fibroblast #> PDK4                        0             0.000000            0.6768172 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             1.022955            0.5890163 #> GZMB                        0             0.000000            0.0000000 #> TSC2                        0             0.000000            0.0000000 #>          X76_Y-75..Fibroblast X77_Y-75..Fibroblast X73_Y-75..Fibroblast #> PDK4                0.6614298            0.3485247             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.2812211            0.3577688             1.490436 #> GZMB                0.0000000            0.2892079             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X75_Y-76..Fibroblast X74_Y-76..Fibroblast X73_Y-76..Fibroblast #> PDK4                0.1847507            0.3341206            0.2290478 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.3106980            0.0000000            0.7092829 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.1975823            0.0000000            0.0000000 #>          X76_Y-76..Fibroblast X78_Y-76..Fibroblast X77_Y-76..Fibroblast #> PDK4                0.0000000             0.000000            0.5483143 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.7895619             1.291578            1.0889630 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.0000000 #>          X72_Y-76..Fibroblast X74_Y-77..Fibroblast X73_Y-77..Fibroblast #> PDK4                0.3562965            0.2669971            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.7260711            0.6887145            0.6896522 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X76_Y-77..Fibroblast X75_Y-77..Fibroblast X77_Y-77..Fibroblast #> PDK4                0.4338479              0.00000            0.8224714 #> TNFRSF17            0.0000000              0.00000            0.0000000 #> ICAM3               0.0000000              0.00000            0.0000000 #> FAP                 1.2300615              1.01996            0.0000000 #> GZMB                0.0000000              0.00000            0.0000000 #> TSC2                0.0000000              0.00000            0.0000000 #>          X72_Y-77..Fibroblast X73_Y-78..Fibroblast X76_Y-78..Fibroblast #> PDK4                0.5487294            0.0000000             0.276085 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 1.1515904            0.7121223             1.813943 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X72_Y-78..Fibroblast X78_Y-78..Fibroblast X75_Y-78..Fibroblast #> PDK4                0.3463830             0.000000            0.2493914 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.5435974             1.768868            1.4358002 #> GZMB                0.0000000             0.000000            0.2411640 #> TSC2                0.0000000             0.000000            0.0000000 #>          X74_Y-78..Fibroblast X75_Y-79..Fibroblast X74_Y-79..Fibroblast #> PDK4                 0.000000            0.2241966             0.000000 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  1.354988            1.2478439             1.158515 #> GZMB                 0.000000            0.2067120             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X73_Y-79..Fibroblast X78_Y-72..Fibroblast X73_Y-73..Fibroblast #> PDK4                 0.000000             1.186929                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  1.001044             0.000000                    0 #> GZMB                 0.000000             0.000000                    0 #> TSC2                 0.000000             0.000000                    0 #>          X78_Y-75..Fibroblast X78_Y-77..Fibroblast X61_Y-68..Fibroblast #> PDK4                 0.000000             0.000000            0.6559976 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  0.000000             1.291578            0.0000000 #> GZMB                 1.735247             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X61_Y-69..Fibroblast X62_Y-69..Fibroblast X63_Y-70..Fibroblast #> PDK4                 1.336959             1.185441            0.0000000 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  0.000000             1.006093            0.7149451 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X64_Y-70..Fibroblast X65_Y-71..Fibroblast X62_Y-71..Fibroblast #> PDK4                0.0000000            0.0000000                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.8159799            0.8159799                    0 #> GZMB                0.8159799            0.8159799                    0 #> TSC2                0.5615951            0.5615951                    0 #>          X61_Y-71..Fibroblast X62_Y-72..Fibroblast X65_Y-72..Fibroblast #> PDK4                        0            0.0000000             0.000000 #> TNFRSF17                    0            0.0000000             0.000000 #> ICAM3                       0            0.0000000             0.000000 #> FAP                         0            0.0000000             1.033836 #> GZMB                        0            0.8572902             1.283970 #> TSC2                        0            0.0000000             0.000000 #>          X66_Y-73..Fibroblast X62_Y-70..Fibroblast X60_Y-71..Fibroblast #> PDK4                 1.090199            0.0000000            0.8889342 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.110762            0.8579341            0.0000000 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 1.146465            0.0000000            0.8889342 #>          X64_Y-72..Fibroblast X65_Y-73..Fibroblast X65_Y-74..Fibroblast #> PDK4                 0.000000                    0            0.0000000 #> TNFRSF17             0.000000                    0            0.0000000 #> ICAM3                0.000000                    0            0.0000000 #> FAP                  0.000000                    0            1.5134401 #> GZMB                 1.925955                    0            0.6555059 #> TSC2                 0.000000                    0            0.0000000 #>          X66_Y-76..Fibroblast X63_Y-73..Fibroblast X65_Y-75..Fibroblast #> PDK4                0.0000000                    0              0.00000 #> TNFRSF17            0.0000000                    0              0.00000 #> ICAM3               0.0000000                    0              0.00000 #> FAP                 0.6611277                    0              3.27753 #> GZMB                0.0000000                    0              3.27753 #> TSC2                0.0000000                    0              0.00000 #>          X66_Y-77..Fibroblast X67_Y-77..Fibroblast X67_Y-73..Fibroblast #> PDK4                0.0000000            0.3918173            0.9191032 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.8820762            1.7884370            0.8171265 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.4037114            0.0000000 #>          X68_Y-74..Fibroblast X71_Y-74..Fibroblast X68_Y-75..Fibroblast #> PDK4                0.4610518            0.9293706            1.7642457 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.4610518            0.9293706            0.8068407 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X71_Y-75..Fibroblast X72_Y-75..Fibroblast X69_Y-75..Fibroblast #> PDK4                 1.239161            0.0000000             0.957405 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  2.348485            0.6655943             0.000000 #> GZMB                 0.000000            0.0000000             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X67_Y-75..Fibroblast X70_Y-76..Fibroblast X67_Y-76..Fibroblast #> PDK4                        0            0.9929658                    0 #> TNFRSF17                    0            0.0000000                    0 #> ICAM3                       0            0.0000000                    0 #> FAP                         0            2.2653125                    0 #> GZMB                        0            0.0000000                    0 #> TSC2                        0            0.0000000                    0 #>          X71_Y-76..Fibroblast X68_Y-76..Fibroblast X71_Y-77..Fibroblast #> PDK4                0.9929658                    0             0.000000 #> TNFRSF17            0.0000000                    0             0.000000 #> ICAM3               0.0000000                    0             0.000000 #> FAP                 2.2653125                    0             0.000000 #> GZMB                1.0889305                    0             1.088931 #> TSC2                0.0000000                    0             0.000000 #>          X70_Y-77..Fibroblast X68_Y-77..Fibroblast X69_Y-77..Fibroblast #> PDK4                        0            0.0000000             0.000000 #> TNFRSF17                    0            0.0000000             0.000000 #> ICAM3                       0            0.0000000             0.000000 #> FAP                         0            0.8074227             1.078122 #> GZMB                        0            0.0000000             0.000000 #> TSC2                        0            0.8074227             0.000000 #>          X69_Y-78..Fibroblast X71_Y-78..Fibroblast X72_Y-79..Fibroblast #> PDK4                1.7767548            0.9552118            0.6432827 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.8085913            0.0000000            0.9723609 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X71_Y-79..Fibroblast X68_Y-73..Fibroblast X67_Y-74..Fibroblast #> PDK4                0.6383262             0.000000            0.7659193 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 1.2627589             1.021408            0.0000000 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.0000000 #>          X69_Y-76..Fibroblast X70_Y-79..Fibroblast X58_Y-73..Fibroblast #> PDK4                0.0000000            0.7641694                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.8496005            0.0000000                    0 #> GZMB                0.0000000            0.0000000                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X59_Y-75..Fibroblast X54_Y-76..Fibroblast X58_Y-76..Fibroblast #> PDK4                 1.262634            0.5624530                    0 #> TNFRSF17             0.000000            0.0000000                    0 #> ICAM3                0.000000            0.0000000                    0 #> FAP                  1.794685            0.5915418                    0 #> GZMB                 0.000000            0.0000000                    0 #> TSC2                 0.000000            0.0000000                    0 #>          X59_Y-76..Fibroblast X54_Y-77..Fibroblast X55_Y-78..Fibroblast #> PDK4                        0            0.2748151             0.000000 #> TNFRSF17                    0            0.0000000             0.000000 #> ICAM3                       0            0.0000000             0.000000 #> FAP                         0            0.5624093             1.169525 #> GZMB                        0            0.0000000             0.000000 #> TSC2                        0            0.0000000             0.000000 #>          X56_Y-79..Fibroblast X55_Y-77..Fibroblast X55_Y-79..Fibroblast #> PDK4                0.0000000            0.0000000            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            0.3865539            0.6981117 #> GZMB                0.4689218            0.0000000            0.0000000 #> TSC2                0.4689218            0.0000000            0.0000000 #>          X68_Y-67..Fibroblast X73_Y-67..Fibroblast X69_Y-68..Fibroblast #> PDK4                0.0000000            0.0000000            0.3419437 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.1015223            0.0000000            0.0000000 #> GZMB                0.4109156            0.0000000            0.0000000 #> TSC2                0.0000000            0.9994398            0.0000000 #>          X73_Y-68..Fibroblast X72_Y-68..Fibroblast X73_Y-69..Fibroblast #> PDK4                        0             0.000000            0.0000000 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             1.198748            0.8990608 #> GZMB                        0             0.000000            0.0000000 #> TSC2                        0             0.000000            0.0000000 #>          X69_Y-69..Fibroblast X68_Y-69..Fibroblast X71_Y-69..Fibroblast #> PDK4                1.7455164             1.523264                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 0.4792546             1.188397                    0 #> GZMB                0.0000000             0.000000                    0 #> TSC2                0.0000000             0.000000                    0 #>          X72_Y-70..Fibroblast X68_Y-70..Fibroblast X71_Y-70..Fibroblast #> PDK4                        0              0.00000                    0 #> TNFRSF17                    0              0.00000                    0 #> ICAM3                       0              0.00000                    0 #> FAP                         0              1.11197                    0 #> GZMB                        0              0.00000                    0 #> TSC2                        0              0.00000                    0 #>          X70_Y-70..Fibroblast X67_Y-70..Fibroblast X67_Y-71..Fibroblast #> PDK4                0.6919979            0.8580134            0.8580134 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.6427031            1.0536484            0.0000000 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X72_Y-72..Fibroblast X68_Y-68..Fibroblast X73_Y-70..Fibroblast #> PDK4                0.0000000                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 0.7499805                    0                    0 #> GZMB                0.0000000                    0                    0 #> TSC2                0.0000000                    0                    0 #>          X52_Y-72..Fibroblast X53_Y-73..Fibroblast X52_Y-73..Fibroblast #> PDK4                 0.000000            0.6544894            0.6544894 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.860528            1.1334822            1.2343726 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X50_Y-73..Fibroblast X50_Y-74..Fibroblast X53_Y-74..Fibroblast #> PDK4                 1.538482             1.538482            0.3122011 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  1.987516             1.987516            0.3373107 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X52_Y-74..Fibroblast X53_Y-75..Fibroblast X54_Y-75..Fibroblast #> PDK4                 1.409789            0.3666545            0.8455459 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.393870            1.5966340            1.7962133 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.5043279            0.5673689 #>          X53_Y-76..Fibroblast X48_Y-77..Fibroblast X54_Y-78..Fibroblast #> PDK4                 0.000000            0.4825138             0.000000 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  1.048772            0.8607933             1.094693 #> GZMB                 0.000000            0.0000000             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X48_Y-78..Fibroblast X53_Y-78..Fibroblast X52_Y-78..Fibroblast #> PDK4                0.2193245             0.000000              0.00000 #> TNFRSF17            0.0000000             0.000000              0.00000 #> ICAM3               0.0000000             0.000000              0.00000 #> FAP                 0.7292226             0.000000              1.91481 #> GZMB                0.0000000             2.317563              0.00000 #> TSC2                0.0000000             0.000000              0.00000 #>          X49_Y-78..Fibroblast X50_Y-79..Fibroblast X49_Y-79..Fibroblast #> PDK4                0.0000000             0.000000            0.0000000 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 1.1389010             1.469185            0.7243997 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.6078321             0.531853            0.3868022 #>          X53_Y-79..Fibroblast X51_Y-79..Fibroblast X52_Y-79..Fibroblast #> PDK4                 0.000000            0.6271664            0.9496826 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.000000            2.5092042            0.8274260 #> GZMB                 4.564657            0.0000000            0.6420270 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X50_Y-78..Fibroblast X43_Y-91..Fibroblast X46_Y-91..Fibroblast #> PDK4                0.0000000            0.2806402            0.4966986 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.8983322            1.2302260            2.3778217 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.5318530            0.0000000            0.0000000 #>          X44_Y-91..Fibroblast X43_Y-92..Fibroblast X42_Y-92..Fibroblast #> PDK4                        0             0.000000            0.0000000 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             1.309267            0.3175374 #> GZMB                        0             0.000000            0.0000000 #> TSC2                        0             0.000000            0.0000000 #>          X44_Y-92..Fibroblast X45_Y-92..Fibroblast X42_Y-93..Fibroblast #> PDK4                 1.682221                    0            0.5429468 #> TNFRSF17             0.000000                    0            0.0000000 #> ICAM3                0.000000                    0            0.0000000 #> FAP                  0.000000                    0            0.5938717 #> GZMB                 0.000000                    0            0.0000000 #> TSC2                 0.000000                    0            0.0000000 #>          X48_Y-93..Fibroblast X43_Y-93..Fibroblast X44_Y-93..Fibroblast #> PDK4                0.4936461            0.2273606            0.8144214 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            1.2304108            0.5050297 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.3321904 #>          X47_Y-93..Fibroblast X46_Y-93..Fibroblast X45_Y-93..Fibroblast #> PDK4                 0.000000                    0            0.0000000 #> TNFRSF17             0.000000                    0            0.0000000 #> ICAM3                0.000000                    0            0.0000000 #> FAP                  2.001511                    0            0.3397727 #> GZMB                 0.000000                    0            0.0000000 #> TSC2                 0.000000                    0            0.4798306 #>          X44_Y-94..Fibroblast X43_Y-94..Fibroblast X45_Y-94..Fibroblast #> PDK4                1.2816768            0.0000000            0.3469518 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.3823096            0.7599635            0.0000000 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X42_Y-94..Fibroblast X46_Y-94..Fibroblast X47_Y-94..Fibroblast #> PDK4                0.2497042                    0             0.000000 #> TNFRSF17            0.0000000                    0             0.000000 #> ICAM3               0.0000000                    0             0.000000 #> FAP                 0.5626750                    0             2.405894 #> GZMB                0.0000000                    0             0.000000 #> TSC2                0.2425889                    0             0.000000 #>          X44_Y-95..Fibroblast X46_Y-95..Fibroblast X43_Y-95..Fibroblast #> PDK4                0.2030953             0.000000            0.2176021 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.0000000             2.326301            0.0000000 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.0000000 #>          X47_Y-95..Fibroblast X45_Y-95..Fibroblast X42_Y-95..Fibroblast #> PDK4                0.5379958            0.0000000            0.3648978 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.6014735            0.2833405            0.9037711 #> GZMB                0.3115109            0.0000000            0.0000000 #> TSC2                0.4530305            0.0000000            0.0000000 #>          X47_Y-96..Fibroblast X46_Y-96..Fibroblast X43_Y-96..Fibroblast #> PDK4                0.7081519            0.3234365            0.6271452 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.8011428            0.7081351            0.8351826 #> GZMB                0.2010946            0.0000000            0.0000000 #> TSC2                0.1798499            0.0000000            0.0000000 #>          X44_Y-96..Fibroblast X42_Y-96..Fibroblast X45_Y-96..Fibroblast #> PDK4                0.6519050            0.6850301            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.3642899            0.4009469            0.7690565 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.1663220            0.0000000            0.0000000 #>          X48_Y-96..Fibroblast X47_Y-97..Fibroblast X46_Y-97..Fibroblast #> PDK4                 1.133571            1.6081999            1.8130529 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.000000            0.3561119            0.2333204 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.2333204 #>          X45_Y-97..Fibroblast X43_Y-97..Fibroblast X42_Y-97..Fibroblast #> PDK4                1.2329940            1.1318242            0.2666561 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.3791456            0.7228483            0.2628046 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.3791456            0.0000000            0.3256353 #>          X44_Y-97..Fibroblast X48_Y-97..Fibroblast X44_Y-98..Fibroblast #> PDK4                0.8760606             1.131645            0.0000000 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.1859414             1.329591            0.5860138 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.1663220             0.000000            0.0000000 #>          X42_Y-91..Fibroblast X46_Y-92..Fibroblast X24_Y-73..Fibroblast #> PDK4                0.0000000                    0              0.00000 #> TNFRSF17            0.0000000                    0              0.00000 #> ICAM3               0.0000000                    0              0.00000 #> FAP                 0.7407994                    0              0.00000 #> GZMB                0.3280252                    0              1.03319 #> TSC2                0.0000000                    0              0.00000 #>          X23_Y-73..Fibroblast X22_Y-73..Fibroblast X22_Y-74..Fibroblast #> PDK4                  0.00000             0.000000             0.000000 #> TNFRSF17              0.00000             0.000000             0.000000 #> ICAM3                 0.00000             0.000000             0.000000 #> FAP                   1.17442             1.236559             1.854839 #> GZMB                  0.00000             0.000000             0.000000 #> TSC2                  0.00000             0.000000             0.000000 #>          X23_Y-75..Fibroblast X22_Y-76..Fibroblast X24_Y-76..Fibroblast #> PDK4                 2.379753             0.000000                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  0.000000             2.769681                    0 #> GZMB                 0.000000             0.000000                    0 #> TSC2                 0.000000             0.000000                    0 #>          X23_Y-77..Fibroblast X24_Y-77..Fibroblast X21_Y-77..Fibroblast #> PDK4                   2.0486                    0             0.000000 #> TNFRSF17               0.0000                    0             0.000000 #> ICAM3                  0.0000                    0             0.000000 #> FAP                    0.0000                    0             1.587687 #> GZMB                   0.0000                    0             0.000000 #> TSC2                   0.0000                    0             0.000000 #>          X23_Y-78..Fibroblast X22_Y-79..Fibroblast X23_Y-79..Fibroblast #> PDK4                 2.179321            0.9124039            0.5678796 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.000000            0.4727918            0.0000000 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X22_Y-75..Fibroblast X22_Y-77..Fibroblast X26_Y-73..Fibroblast #> PDK4                  1.81748             0.000000            1.3296834 #> TNFRSF17              0.00000             0.000000            0.0000000 #> ICAM3                 0.00000             0.000000            0.0000000 #> FAP                   0.00000             1.587687            0.6351334 #> GZMB                  0.00000             0.000000            0.0000000 #> TSC2                  0.00000             0.000000            0.0000000 #>          X28_Y-73..Fibroblast X26_Y-74..Fibroblast X25_Y-74..Fibroblast #> PDK4                0.0000000            0.0000000             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.8062601            0.8711444             2.062278 #> GZMB                0.9132741            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X24_Y-74..Fibroblast X28_Y-74..Fibroblast X23_Y-74..Fibroblast #> PDK4                 3.729311             0.000000             1.752149 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  4.410381             1.004747             0.000000 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             0.000000 #>          X28_Y-75..Fibroblast X24_Y-75..Fibroblast X29_Y-76..Fibroblast #> PDK4                        0            1.3487761                    0 #> TNFRSF17                    0            0.0000000                    0 #> ICAM3                       0            0.0000000                    0 #> FAP                         0            0.7350635                    0 #> GZMB                        0            0.0000000                    0 #> TSC2                        0            0.0000000                    0 #>          X27_Y-76..Fibroblast X26_Y-76..Fibroblast X28_Y-76..Fibroblast #> PDK4                 0.000000            0.0000000                    0 #> TNFRSF17             0.000000            0.0000000                    0 #> ICAM3                0.000000            0.0000000                    0 #> FAP                  2.265416            0.9721727                    0 #> GZMB                 0.000000            0.0000000                    0 #> TSC2                 0.000000            0.0000000                    0 #>          X29_Y-77..Fibroblast X27_Y-79..Fibroblast X28_Y-72..Fibroblast #> PDK4                        0             1.155549                    0 #> TNFRSF17                    0             0.000000                    0 #> ICAM3                       0             0.000000                    0 #> FAP                         0             0.000000                    0 #> GZMB                        0             0.000000                    0 #> TSC2                        0             0.000000                    0 #>          X25_Y-72..Fibroblast X29_Y-73..Fibroblast X27_Y-73..Fibroblast #> PDK4                  0.00000             0.000000            0.5425815 #> TNFRSF17              0.00000             0.000000            0.0000000 #> ICAM3                 0.00000             0.000000            0.0000000 #> FAP                   0.00000             0.000000            0.4031300 #> GZMB                  1.03319             1.217699            0.0000000 #> TSC2                  0.00000             0.000000            0.0000000 #>          X25_Y-73..Fibroblast X29_Y-74..Fibroblast X27_Y-74..Fibroblast #> PDK4                0.7933533                    0             0.000000 #> TNFRSF17            0.0000000                    0             0.000000 #> ICAM3               0.0000000                    0             0.000000 #> FAP                 0.7786778                    0             1.004747 #> GZMB                0.0000000                    0             0.000000 #> TSC2                0.0000000                    0             0.000000 #>          X26_Y-75..Fibroblast X25_Y-75..Fibroblast X27_Y-75..Fibroblast #> PDK4                0.7985048            1.3487761             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.0000000            0.7350635             1.293243 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X25_Y-76..Fibroblast X28_Y-77..Fibroblast X25_Y-77..Fibroblast #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X25_Y-78..Fibroblast X27_Y-78..Fibroblast X28_Y-78..Fibroblast #> PDK4                        0             0.000000            0.5397357 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             0.000000            1.0974364 #> GZMB                        0             1.812122            0.0000000 #> TSC2                        0             0.000000            0.0000000 #>          X24_Y-78..Fibroblast X28_Y-79..Fibroblast X29_Y-79..Fibroblast #> PDK4                 1.385737            0.8044036            0.4944976 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.000000            0.9458929            0.6537565 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X24_Y-79..Fibroblast X33_Y-66..Fibroblast X30_Y-69..Fibroblast #> PDK4                 1.385737                    0                    0 #> TNFRSF17             0.000000                    0                    0 #> ICAM3                0.000000                    0                    0 #> FAP                  0.000000                    0                    0 #> GZMB                 0.000000                    0                    0 #> TSC2                 0.000000                    0                    0 #>          X34_Y-70..Fibroblast X35_Y-70..Fibroblast X33_Y-71..Fibroblast #> PDK4                0.7002576               0.0000             0.000000 #> TNFRSF17            0.0000000               0.0000             0.000000 #> ICAM3               0.0000000               0.0000             0.000000 #> FAP                 0.0000000               1.3638             1.365733 #> GZMB                0.0000000               0.0000             0.000000 #> TSC2                0.0000000               0.0000             0.000000 #>          X31_Y-72..Fibroblast X34_Y-67..Fibroblast X31_Y-68..Fibroblast #> PDK4                        0             2.609251                    0 #> TNFRSF17                    0             0.000000                    0 #> ICAM3                       0             0.000000                    0 #> FAP                         0             1.159865                    0 #> GZMB                        0             0.000000                    0 #> TSC2                        0             0.000000                    0 #>          X33_Y-68..Fibroblast X32_Y-69..Fibroblast X35_Y-69..Fibroblast #> PDK4                        0                    0            0.7632981 #> TNFRSF17                    0                    0            0.0000000 #> ICAM3                       0                    0            0.0000000 #> FAP                         0                    0            0.0000000 #> GZMB                        0                    0            0.0000000 #> TSC2                        0                    0            0.0000000 #>          X33_Y-69..Fibroblast X34_Y-69..Fibroblast X30_Y-71..Fibroblast #> PDK4                 0.000000             1.654016            0.6752893 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  0.000000             0.000000            0.0000000 #> GZMB                 4.051736             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X34_Y-71..Fibroblast X33_Y-72..Fibroblast X34_Y-72..Fibroblast #> PDK4                        0             2.017612             0.000000 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             0.000000             0.488648 #> GZMB                        0             0.000000             0.000000 #> TSC2                        0             0.000000             0.000000 #>          X30_Y-64..Fibroblast X30_Y-65..Fibroblast X32_Y-65..Fibroblast #> PDK4                 2.231594             1.724760                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  1.061403             0.781791                    0 #> GZMB                 0.000000             0.000000                    0 #> TSC2                 0.000000             0.000000                    0 #>          X30_Y-66..Fibroblast X31_Y-65..Fibroblast X35_Y-79..Fibroblast #> PDK4                 1.139451             1.735677             2.687373 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  0.000000             1.005160             0.000000 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             0.000000 #>          X33_Y-79..Fibroblast X31_Y-80..Fibroblast X32_Y-80..Fibroblast #> PDK4                0.8537074             0.000000                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 0.0000000             3.944159                    0 #> GZMB                0.0000000             0.000000                    0 #> TSC2                0.0000000             0.000000                    0 #>          X30_Y-80..Fibroblast X33_Y-80..Fibroblast X29_Y-80..Fibroblast #> PDK4                0.3806975             0.000000             0.696345 #> TNFRSF17            0.0000000             0.000000             0.000000 #> ICAM3               0.0000000             0.000000             0.000000 #> FAP                 0.0000000             1.369636             0.000000 #> GZMB                0.0000000             0.000000             0.000000 #> TSC2                0.0000000             0.000000             0.000000 #>          X36_Y-80..Fibroblast X32_Y-81..Fibroblast X35_Y-81..Fibroblast #> PDK4                1.2288829             1.138189             1.345496 #> TNFRSF17            0.0000000             0.000000             0.000000 #> ICAM3               0.0000000             0.000000             0.000000 #> FAP                 0.9481744             0.000000             0.000000 #> GZMB                0.0000000             0.000000             0.000000 #> TSC2                0.0000000             0.000000             0.000000 #>          X30_Y-81..Fibroblast X33_Y-81..Fibroblast X34_Y-81..Fibroblast #> PDK4                  0.90416             1.593465            0.0000000 #> TNFRSF17              0.00000             0.000000            0.0000000 #> ICAM3                 0.00000             0.000000            0.0000000 #> FAP                   0.00000             0.000000            0.9994398 #> GZMB                  0.00000             0.000000            0.0000000 #> TSC2                  0.00000             0.000000            0.0000000 #>          X31_Y-81..Fibroblast X36_Y-81..Fibroblast X29_Y-81..Fibroblast #> PDK4                0.0000000            0.7484670            1.2426957 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.8345991            0.8243111            0.5427514 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X34_Y-82..Fibroblast X35_Y-82..Fibroblast X33_Y-82..Fibroblast #> PDK4                0.7339068             1.208952                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 0.6824758             1.102937                    0 #> GZMB                0.0000000             0.000000                    0 #> TSC2                0.0000000             0.000000                    0 #>          X33_Y-83..Fibroblast X35_Y-83..Fibroblast X29_Y-83..Fibroblast #> PDK4                0.0000000             1.212053                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 0.4891536             1.044915                    0 #> GZMB                0.0000000             0.000000                    0 #> TSC2                0.0000000             0.000000                    0 #>          X30_Y-83..Fibroblast X34_Y-83..Fibroblast X35_Y-84..Fibroblast #> PDK4                        0            0.5404817            0.7114356 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.7954389            0.4809906 #> GZMB                        0            0.0000000            0.0000000 #> TSC2                        0            0.0000000            0.0000000 #>          X30_Y-84..Fibroblast X29_Y-84..Fibroblast X34_Y-84..Fibroblast #> PDK4                 1.218173             1.840844            0.2649011 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  0.000000             0.344960            0.5094787 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X32_Y-84..Fibroblast X31_Y-84..Fibroblast X33_Y-84..Fibroblast #> PDK4                0.9342352            0.6840042                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.0000000            0.0000000                    0 #> GZMB                0.2769729            0.3621954                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X31_Y-85..Fibroblast X35_Y-85..Fibroblast X32_Y-85..Fibroblast #> PDK4                0.7410046             0.000000             0.994311 #> TNFRSF17            0.0000000             0.000000             0.000000 #> ICAM3               0.0000000             0.000000             0.000000 #> FAP                 0.0000000             1.329805             0.000000 #> GZMB                0.0000000             0.000000             0.000000 #> TSC2                0.0000000             0.000000             0.000000 #>          X35_Y-80..Fibroblast X34_Y-80..Fibroblast X30_Y-82..Fibroblast #> PDK4                1.7226003            1.6578032             1.771306 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.7434965            0.8217817             0.000000 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X31_Y-83..Fibroblast X32_Y-83..Fibroblast X42_Y-64..Fibroblast #> PDK4                        0                    0            0.6368079 #> TNFRSF17                    0                    0            0.0000000 #> ICAM3                       0                    0            0.0000000 #> FAP                         0                    0            1.8839165 #> GZMB                        0                    0            0.0000000 #> TSC2                        0                    0            0.5248954 #>          X39_Y-64..Fibroblast X41_Y-64..Fibroblast X40_Y-64..Fibroblast #> PDK4                0.0000000             0.000000             0.000000 #> TNFRSF17            0.0000000             0.000000             0.000000 #> ICAM3               0.0000000             0.000000             0.000000 #> FAP                 0.6019819             0.805681             1.824942 #> GZMB                0.6296916             0.000000             0.000000 #> TSC2                0.0000000             0.000000             0.000000 #>          X40_Y-65..Fibroblast X39_Y-65..Fibroblast X41_Y-65..Fibroblast #> PDK4                 0.000000            0.4512675            0.0000000 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  2.298971            0.4514864            0.0000000 #> GZMB                 0.000000            0.4722687            0.0000000 #> TSC2                 0.000000            0.4627420            0.6971418 #>          X42_Y-65..Fibroblast X38_Y-65..Fibroblast X39_Y-66..Fibroblast #> PDK4                0.6368079            0.7220280            0.7220280 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.8104049            0.0000000            0.0000000 #> GZMB                0.0000000            0.7313531            0.7313531 #> TSC2                0.5248954            0.0000000            0.0000000 #>          X40_Y-66..Fibroblast X23_Y-66..Fibroblast X22_Y-66..Fibroblast #> PDK4                        0            0.0000000             0.000000 #> TNFRSF17                    0            0.0000000             0.000000 #> ICAM3                       0            0.0000000             0.000000 #> FAP                         0            0.0000000             0.000000 #> GZMB                        0            0.5804147             1.354301 #> TSC2                        0            0.4689218             0.000000 #>          X22_Y-67..Fibroblast X23_Y-68..Fibroblast X21_Y-68..Fibroblast #> PDK4                        0                    0             0.000000 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             1.148884 #>          X23_Y-70..Fibroblast X22_Y-71..Fibroblast X23_Y-71..Fibroblast #> PDK4                 1.066624               2.0371                    0 #> TNFRSF17             0.000000               0.0000                    0 #> ICAM3                0.000000               0.0000                    0 #> FAP                  1.066624               0.0000                    0 #> GZMB                 0.000000               0.0000                    0 #> TSC2                 0.000000               0.0000                    0 #>          X22_Y-72..Fibroblast X22_Y-68..Fibroblast X22_Y-69..Fibroblast #> PDK4                 4.175964                    0                    0 #> TNFRSF17             0.000000                    0                    0 #> ICAM3                0.000000                    0                    0 #> FAP                  0.000000                    0                    0 #> GZMB                 0.000000                    0                    0 #> TSC2                 0.000000                    0                    0 #>          X24_Y-80..Fibroblast X27_Y-80..Fibroblast X25_Y-80..Fibroblast #> PDK4                0.9784680            0.7434965            0.6375373 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.2801672            0.0000000            0.0000000 #> GZMB                0.2942480            0.0000000            0.6375373 #> TSC2                0.0000000            0.0000000            0.6289972 #>          X23_Y-80..Fibroblast X28_Y-81..Fibroblast X26_Y-81..Fibroblast #> PDK4                0.2924386             0.000000             1.907532 #> TNFRSF17            0.0000000             0.000000             0.000000 #> ICAM3               0.0000000             0.000000             0.000000 #> FAP                 0.0000000             1.626594             0.000000 #> GZMB                0.0000000             0.000000             0.000000 #> TSC2                0.0000000             0.000000             0.000000 #>          X24_Y-82..Fibroblast X28_Y-82..Fibroblast X27_Y-82..Fibroblast #> PDK4                        0            1.8159554             3.043831 #> TNFRSF17                    0            0.0000000             0.000000 #> ICAM3                       0            0.0000000             0.000000 #> FAP                         0            0.5414235             0.000000 #> GZMB                        0            0.0000000             0.000000 #> TSC2                        0            0.0000000             0.000000 #>          X29_Y-82..Fibroblast X26_Y-82..Fibroblast X26_Y-83..Fibroblast #> PDK4                 1.043203             1.400111            0.3535173 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  0.000000             0.000000            0.3535173 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X24_Y-83..Fibroblast X25_Y-83..Fibroblast X28_Y-84..Fibroblast #> PDK4                        0                    0             1.218351 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.313600 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X25_Y-84..Fibroblast X25_Y-79..Fibroblast X26_Y-79..Fibroblast #> PDK4                0.5321931             1.385737            0.7284347 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.6294819             0.000000            0.7624308 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.0000000 #>          X26_Y-80..Fibroblast X28_Y-80..Fibroblast X23_Y-81..Fibroblast #> PDK4                0.7863651                    0             1.109451 #> TNFRSF17            0.0000000                    0             0.000000 #> ICAM3               0.0000000                    0             0.000000 #> FAP                 0.0000000                    0             0.000000 #> GZMB                0.0000000                    0             0.000000 #> TSC2                0.0000000                    0             0.000000 #>          X25_Y-81..Fibroblast X25_Y-82..Fibroblast X27_Y-83..Fibroblast #> PDK4                 0.000000             1.137039             1.166727 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  2.274077             1.104611             0.000000 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             0.000000 #>          X28_Y-83..Fibroblast X26_Y-84..Fibroblast X24_Y-84..Fibroblast #> PDK4                 1.223454            0.5555272                    0 #> TNFRSF17             0.000000            0.0000000                    0 #> ICAM3                0.000000            0.0000000                    0 #> FAP                  0.000000            0.5555272                    0 #> GZMB                 0.000000            0.0000000                    0 #> TSC2                 0.000000            0.0000000                    0 #>          X29_Y-85..Fibroblast X25_Y-85..Fibroblast X26_Y-85..Fibroblast #> PDK4                 2.001998             1.241784                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  0.492800             1.468791                    0 #> GZMB                 0.000000             0.000000                    0 #> TSC2                 0.000000             0.000000                    0 #>          X23_Y-85..Fibroblast X24_Y-66..Fibroblast X25_Y-66..Fibroblast #> PDK4                 1.536727            0.0000000            0.0000000 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.000000            0.6233351            0.4848162 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X29_Y-66..Fibroblast X28_Y-67..Fibroblast X24_Y-67..Fibroblast #> PDK4                1.3293598             1.371343             0.000000 #> TNFRSF17            0.0000000             0.000000             0.000000 #> ICAM3               0.0000000             0.000000             0.000000 #> FAP                 0.0000000             0.000000             1.940315 #> GZMB                0.5371206             0.000000             0.000000 #> TSC2                0.0000000             0.000000             0.000000 #>          X30_Y-67..Fibroblast X25_Y-67..Fibroblast X26_Y-67..Fibroblast #> PDK4                  0.98542            0.0000000             0.000000 #> TNFRSF17              0.00000            0.0000000             0.000000 #> ICAM3                 0.00000            0.0000000             0.000000 #> FAP                   0.98542            0.4848162             1.248885 #> GZMB                  0.00000            0.0000000             0.000000 #> TSC2                  0.00000            0.0000000             0.000000 #>          X27_Y-67..Fibroblast X29_Y-67..Fibroblast X24_Y-68..Fibroblast #> PDK4                0.7650447             1.279491             0.000000 #> TNFRSF17            0.0000000             0.000000             0.000000 #> ICAM3               0.0000000             0.000000             0.000000 #> FAP                 0.7098303             1.262179             1.132639 #> GZMB                0.0000000             0.000000             0.000000 #> TSC2                0.0000000             0.000000             0.000000 #>          X25_Y-68..Fibroblast X28_Y-68..Fibroblast X27_Y-68..Fibroblast #> PDK4                 1.187456            0.6676793            0.9187379 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.159865            0.7458622            0.9628370 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X30_Y-68..Fibroblast X26_Y-69..Fibroblast X25_Y-69..Fibroblast #> PDK4                        0             1.036915              1.75092 #> TNFRSF17                    0             0.000000              0.00000 #> ICAM3                       0             0.000000              0.00000 #> FAP                         0             1.055035              0.00000 #> GZMB                        0             0.000000              0.00000 #> TSC2                        0             0.000000              0.00000 #>          X27_Y-69..Fibroblast X23_Y-69..Fibroblast X29_Y-69..Fibroblast #> PDK4                0.8809836                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 1.0006116                    0                    0 #> GZMB                0.0000000                    0                    0 #> TSC2                0.0000000                    0                    0 #>          X24_Y-69..Fibroblast X29_Y-70..Fibroblast X24_Y-70..Fibroblast #> PDK4                0.7999682                    0             1.066624 #> TNFRSF17            0.0000000                    0             0.000000 #> ICAM3               0.0000000                    0             0.000000 #> FAP                 0.7999682                    0             1.066624 #> GZMB                0.0000000                    0             0.000000 #> TSC2                0.0000000                    0             0.000000 #>          X26_Y-70..Fibroblast X25_Y-70..Fibroblast X27_Y-70..Fibroblast #> PDK4                 0.762025             1.035190             3.389573 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  0.760433             1.018674             0.000000 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             0.000000 #>          X25_Y-71..Fibroblast X26_Y-71..Fibroblast X29_Y-71..Fibroblast #> PDK4                0.4103065                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 0.0000000                    0                    0 #> GZMB                0.0000000                    0                    0 #> TSC2                0.0000000                    0                    0 #>          X28_Y-71..Fibroblast X26_Y-72..Fibroblast X23_Y-72..Fibroblast #> PDK4                        0                    0             4.068535 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X26_Y-68..Fibroblast X29_Y-68..Fibroblast X27_Y-71..Fibroblast #> PDK4                0.8261650             0.000000                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 0.8325901             1.262179                    0 #> GZMB                0.0000000             0.000000                    0 #> TSC2                0.0000000             0.000000                    0 #>          X24_Y-71..Fibroblast X29_Y-72..Fibroblast X27_Y-72..Fibroblast #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X24_Y-72..Fibroblast X22_Y-80..Fibroblast X22_Y-82..Fibroblast #> PDK4                  0.00000              0.39878             1.248121 #> TNFRSF17              0.00000              0.00000             0.000000 #> ICAM3                 0.00000              0.00000             0.000000 #> FAP                   0.00000              0.00000             0.000000 #> GZMB                  1.03319              0.00000             0.000000 #> TSC2                  0.00000              0.00000             0.000000 #>          X22_Y-83..Fibroblast X23_Y-83..Fibroblast X22_Y-84..Fibroblast #> PDK4                 1.012995            0.7580258            0.4221184 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.000000            0.5640087            0.0000000 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X23_Y-84..Fibroblast X22_Y-85..Fibroblast X22_Y-81..Fibroblast #> PDK4                0.5276480            0.3568834            0.9755592 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.4230065            0.3026146            0.0000000 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.3829597            0.0000000 #>          X24_Y-81..Fibroblast X21_Y-82..Fibroblast X23_Y-82..Fibroblast #> PDK4                 2.199402             1.132553            0.6296916 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  0.000000             0.000000            0.0000000 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X44_Y-64..Fibroblast X47_Y-64..Fibroblast X46_Y-64..Fibroblast #> PDK4                0.7580665            0.0000000            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.5262313            0.7903272            0.5136136 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X43_Y-64..Fibroblast X45_Y-65..Fibroblast X44_Y-65..Fibroblast #> PDK4                0.7732440            0.3578855            0.6317221 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.7876392            1.0385240            0.6357011 #> GZMB                0.3907623            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X46_Y-65..Fibroblast X43_Y-65..Fibroblast X47_Y-65..Fibroblast #> PDK4                0.0000000            1.0801985            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.3160699            1.0105610            0.9364976 #> GZMB                0.0000000            0.2605082            0.0000000 #> TSC2                0.0000000            0.2099582            0.0000000 #>          X43_Y-66..Fibroblast X47_Y-66..Fibroblast X44_Y-66..Fibroblast #> PDK4                0.8591371              0.00000            0.0000000 #> TNFRSF17            0.0000000              0.00000            0.0000000 #> ICAM3               0.0000000              0.00000            0.0000000 #> FAP                 0.4348158              1.24634            0.5379577 #> GZMB                0.0000000              0.00000            0.0000000 #> TSC2                0.0000000              0.00000            0.0000000 #>          X46_Y-66..Fibroblast X45_Y-66..Fibroblast X44_Y-67..Fibroblast #> PDK4                0.3965608            0.4274901            0.9303529 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.3386482            0.4184115            1.7826211 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.3398804 #>          X46_Y-67..Fibroblast X47_Y-67..Fibroblast X52_Y-64..Fibroblast #> PDK4                0.0000000             0.533897            0.5764164 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.5741413             1.562191            1.3862538 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.0000000 #>          X49_Y-64..Fibroblast X51_Y-65..Fibroblast X52_Y-65..Fibroblast #> PDK4                 1.031144             0.000000            0.3144089 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  1.031144             1.039507            0.6548764 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X50_Y-65..Fibroblast X48_Y-65..Fibroblast X53_Y-65..Fibroblast #> PDK4                0.0000000             1.656912             1.326253 #> TNFRSF17            0.0000000             0.000000             0.000000 #> ICAM3               0.0000000             0.000000             0.000000 #> FAP                 0.3157744             0.000000             0.916307 #> GZMB                0.0000000             0.000000             0.000000 #> TSC2                0.0000000             0.000000             0.000000 #>          X54_Y-65..Fibroblast X49_Y-65..Fibroblast X52_Y-66..Fibroblast #> PDK4                0.8345991            0.3093432             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.0000000            0.3093432             1.037702 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X49_Y-66..Fibroblast X48_Y-66..Fibroblast X50_Y-66..Fibroblast #> PDK4                0.4317633                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 0.4838064                    0                    0 #> GZMB                0.0000000                    0                    0 #> TSC2                0.0000000                    0                    0 #>          X51_Y-66..Fibroblast X52_Y-67..Fibroblast X53_Y-67..Fibroblast #> PDK4                0.0000000            1.0051299            0.7466574 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.6359561            0.0000000            0.0000000 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.6039742            0.5448505 #>          X53_Y-64..Fibroblast X51_Y-64..Fibroblast X51_Y-67..Fibroblast #> PDK4                0.7496016             0.000000             0.000000 #> TNFRSF17            0.0000000             0.000000             0.000000 #> ICAM3               0.0000000             0.000000             0.000000 #> FAP                 0.8320623             1.383324             0.410049 #> GZMB                0.0000000             0.000000             0.000000 #> TSC2                0.0000000             0.000000             0.000000 #>          X41_Y-79..Fibroblast X40_Y-79..Fibroblast X38_Y-80..Fibroblast #> PDK4                0.3289886              0.00000             1.377566 #> TNFRSF17            0.0000000              0.00000             0.000000 #> ICAM3               0.0000000              0.00000             0.000000 #> FAP                 0.2633319              1.64867             1.792074 #> GZMB                0.0000000              0.00000             0.000000 #> TSC2                0.3455523              0.00000             0.000000 #>          X40_Y-80..Fibroblast X41_Y-80..Fibroblast X39_Y-80..Fibroblast #> PDK4                 0.000000                    0             0.259348 #> TNFRSF17             0.000000                    0             0.000000 #> ICAM3                0.000000                    0             0.000000 #> FAP                  1.438465                    0             1.441472 #> GZMB                 0.000000                    0             0.000000 #> TSC2                 0.000000                    0             0.000000 #>          X37_Y-80..Fibroblast X42_Y-80..Fibroblast X37_Y-81..Fibroblast #> PDK4                0.8687486            0.1935227            0.6915246 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.7612093            0.9632688            1.1761266 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X40_Y-81..Fibroblast X39_Y-81..Fibroblast X41_Y-81..Fibroblast #> PDK4                 0.253820            0.2937381             1.541691 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  1.295492            2.0391246             1.262179 #> GZMB                 0.000000            0.2653506             0.000000 #> TSC2                 0.000000            0.2581217             0.000000 #>          X38_Y-81..Fibroblast X42_Y-81..Fibroblast X36_Y-82..Fibroblast #> PDK4                0.4406072            0.0000000            0.5117925 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 2.3976111            0.4207264            1.0305603 #> GZMB                0.3980260            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X40_Y-82..Fibroblast X42_Y-82..Fibroblast X39_Y-82..Fibroblast #> PDK4                0.4371422             0.000000            0.2349905 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 2.0256344             1.267326            2.0707749 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.2064974 #>          X38_Y-82..Fibroblast X41_Y-82..Fibroblast X41_Y-83..Fibroblast #> PDK4                0.7220567            0.3851911            0.2751365 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.3666545            1.9823763            1.6735935 #> GZMB                0.3932621            0.2989107            0.2135076 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X39_Y-83..Fibroblast X38_Y-83..Fibroblast X42_Y-83..Fibroblast #> PDK4                0.2646758            1.0090482            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 2.2888207            1.7089541            1.3753620 #> GZMB                0.0000000            0.5056226            0.3736383 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X40_Y-83..Fibroblast X36_Y-83..Fibroblast X37_Y-83..Fibroblast #> PDK4                 0.000000             0.000000            0.0000000 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  2.201626             1.665985            0.8919597 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X41_Y-84..Fibroblast X40_Y-84..Fibroblast X38_Y-84..Fibroblast #> PDK4                0.8233924             1.567083            0.4939545 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 1.2913438             3.192131            1.3150745 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.0000000 #>          X39_Y-84..Fibroblast X36_Y-84..Fibroblast X37_Y-84..Fibroblast #> PDK4                0.4988378            0.6335396            0.4083696 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 2.0696051            1.7824101            0.4300138 #> GZMB                0.0000000            0.0000000            0.4720003 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X42_Y-84..Fibroblast X41_Y-85..Fibroblast X37_Y-85..Fibroblast #> PDK4                  0.00000            0.8264151            0.5981383 #> TNFRSF17              0.00000            0.0000000            0.0000000 #> ICAM3                 0.00000            0.0000000            0.0000000 #> FAP                   1.07378            0.2561395            0.2570016 #> GZMB                  0.00000            0.0000000            0.6802706 #> TSC2                  0.00000            0.3024643            0.0000000 #>          X42_Y-85..Fibroblast X37_Y-82..Fibroblast X43_Y-72..Fibroblast #> PDK4                0.0000000                    0            0.0000000 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.9767333                    0            0.6671705 #> GZMB                0.6470585                    0            0.6671705 #> TSC2                0.0000000                    0            0.0000000 #>          X44_Y-72..Fibroblast X45_Y-72..Fibroblast X47_Y-72..Fibroblast #> PDK4                0.6678182            0.0000000            0.4776647 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.7593707            1.1830031            0.4115948 #> GZMB                0.3434955            0.3816617            0.4776647 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X43_Y-73..Fibroblast X46_Y-73..Fibroblast X47_Y-73..Fibroblast #> PDK4                0.6506650             0.000000            0.0000000 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.6472455             1.857276            1.5140215 #> GZMB                0.0000000             0.000000            0.4477732 #> TSC2                0.0000000             0.000000            0.0000000 #>          X45_Y-73..Fibroblast X44_Y-73..Fibroblast X44_Y-74..Fibroblast #> PDK4                0.2091433            0.8013707                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.7333962            0.4576566                    0 #> GZMB                0.0000000            0.0000000                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X46_Y-74..Fibroblast X45_Y-74..Fibroblast X43_Y-74..Fibroblast #> PDK4                 0.000000                    0                    0 #> TNFRSF17             0.000000                    0                    0 #> ICAM3                0.000000                    0                    0 #> FAP                  1.078527                    0                    0 #> GZMB                 0.000000                    0                    0 #> TSC2                 0.000000                    0                    0 #>          X47_Y-74..Fibroblast X47_Y-75..Fibroblast X46_Y-75..Fibroblast #> PDK4                 0.000000            0.3214652            0.3613623 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.147189            1.0291937            0.5519578 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X43_Y-75..Fibroblast X44_Y-75..Fibroblast X45_Y-75..Fibroblast #> PDK4                0.5769138            0.4060663                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.5462550            0.5251932                    0 #> GZMB                0.0000000            0.5379958                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X43_Y-76..Fibroblast X47_Y-76..Fibroblast X46_Y-76..Fibroblast #> PDK4                0.4896539            0.2611975                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.9694632            1.1113564                    0 #> GZMB                0.5379958            0.0000000                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X42_Y-76..Fibroblast X44_Y-76..Fibroblast X45_Y-76..Fibroblast #> PDK4                0.4081616            0.4896539             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.8984974            0.9906933             1.195406 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X43_Y-77..Fibroblast X45_Y-77..Fibroblast X44_Y-77..Fibroblast #> PDK4                0.2538053            1.1513173             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 1.3423831            0.0000000             1.174443 #> GZMB                0.0000000            0.8224714             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X47_Y-77..Fibroblast X46_Y-77..Fibroblast X43_Y-78..Fibroblast #> PDK4                0.0000000            0.9210538            0.9921349 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.8226771            0.0000000            1.0739523 #> GZMB                0.0000000            0.6579771            0.4557993 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X44_Y-78..Fibroblast X45_Y-78..Fibroblast X47_Y-78..Fibroblast #> PDK4                0.2307321             0.000000                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 1.0280887             1.631446                    0 #> GZMB                0.0000000             0.000000                    0 #> TSC2                0.0000000             0.000000                    0 #>          X44_Y-79..Fibroblast X47_Y-79..Fibroblast X48_Y-79..Fibroblast #> PDK4                 0.000000             0.467661             0.000000 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  1.415009             0.467661             1.216489 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             0.000000 #>          X46_Y-78..Fibroblast X46_Y-79..Fibroblast X76_Y-79..Fibroblast #> PDK4                 0.000000                    0            0.0000000 #> TNFRSF17             0.000000                    0            0.0000000 #> ICAM3                0.000000                    0            0.0000000 #> FAP                  2.412181                    0            0.9229708 #> GZMB                 0.000000                    0            0.0000000 #> TSC2                 0.000000                    0            0.0000000 #>          X78_Y-79..Fibroblast X77_Y-79..Fibroblast X74_Y-80..Fibroblast #> PDK4                0.0000000                    0            0.0000000 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.7475007                    0            0.5882777 #> GZMB                0.0000000                    0            0.0000000 #> TSC2                0.0000000                    0            0.0000000 #>          X76_Y-80..Fibroblast X73_Y-80..Fibroblast X72_Y-80..Fibroblast #> PDK4                        0            0.1592764            0.2865655 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.7607485            0.8328076 #> GZMB                        0            0.0000000            0.0000000 #> TSC2                        0            0.0000000            0.0000000 #>          X75_Y-80..Fibroblast X74_Y-81..Fibroblast X73_Y-81..Fibroblast #> PDK4                 0.392344                    0            0.1686456 #> TNFRSF17             0.000000                    0            0.0000000 #> ICAM3                0.000000                    0            0.0000000 #> FAP                  0.000000                    0            0.1686456 #> GZMB                 0.000000                    0            0.0000000 #> TSC2                 0.000000                    0            0.0000000 #>          X77_Y-81..Fibroblast X75_Y-81..Fibroblast X72_Y-81..Fibroblast #> PDK4                0.0000000            0.0000000            0.2866975 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.9721727            0.8940675            1.0277466 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X76_Y-81..Fibroblast X73_Y-82..Fibroblast X76_Y-82..Fibroblast #> PDK4                0.5310003            0.1852899            0.7080004 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.0760226            1.0010110            0.0000000 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X74_Y-82..Fibroblast X75_Y-82..Fibroblast X78_Y-82..Fibroblast #> PDK4                0.5154553            0.7080004             1.658831 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 1.1604682            0.0000000             1.996262 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             1.658831 #>          X77_Y-82..Fibroblast X78_Y-83..Fibroblast X74_Y-83..Fibroblast #> PDK4                0.5529436             1.538687            0.0000000 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 1.3285375             0.000000            0.5884619 #> GZMB                0.4861375             0.000000            0.0000000 #> TSC2                1.3019751             0.000000            0.0000000 #>          X77_Y-83..Fibroblast X76_Y-83..Fibroblast X75_Y-83..Fibroblast #> PDK4                0.0000000            0.4822616            0.6751663 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.3617001            0.0000000            0.6525834 #> GZMB                0.2651659            0.0000000            0.0000000 #> TSC2                0.3247640            0.0000000            0.0000000 #>          X73_Y-83..Fibroblast X79_Y-83..Fibroblast X76_Y-84..Fibroblast #> PDK4                0.0000000             2.308031            0.0000000 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.8422332             0.000000            0.4724534 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.0000000 #>          X78_Y-84..Fibroblast X73_Y-84..Fibroblast X74_Y-84..Fibroblast #> PDK4                0.9226102                    0            0.0000000 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.0000000                    0            0.6812148 #> GZMB                0.0000000                    0            0.3119940 #> TSC2                0.0000000                    0            0.0000000 #>          X75_Y-84..Fibroblast X77_Y-84..Fibroblast X79_Y-85..Fibroblast #> PDK4                0.0000000            0.7380881                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.8099696            0.0000000                    0 #> GZMB                0.4921267            0.0000000                    0 #> TSC2                0.2692739            0.0000000                    0 #>          X72_Y-83..Fibroblast X79_Y-65..Fibroblast X74_Y-66..Fibroblast #> PDK4                0.0000000             0.000000            0.2634519 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.4610926             0.606633            0.7370671 #> GZMB                0.0000000             0.000000            0.4057303 #> TSC2                0.0000000             0.000000            0.5627217 #>          X76_Y-66..Fibroblast X75_Y-67..Fibroblast X74_Y-67..Fibroblast #> PDK4                0.0000000            0.6582026             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.0000000            0.9652139             1.901131 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.5266638            0.0000000             0.000000 #>          X79_Y-67..Fibroblast X76_Y-67..Fibroblast X77_Y-67..Fibroblast #> PDK4                        0            0.5941368            0.0000000 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            1.2576799            0.7490756 #> GZMB                        0            0.0000000            0.7490756 #> TSC2                        0            0.0000000            0.0000000 #>          X75_Y-68..Fibroblast X78_Y-68..Fibroblast X77_Y-68..Fibroblast #> PDK4                1.2099225                    0            0.0000000 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.6025548                    0            0.2496919 #> GZMB                0.0000000                    0            0.2496919 #> TSC2                0.0000000                    0            0.3459200 #>          X76_Y-68..Fibroblast X77_Y-69..Fibroblast X74_Y-69..Fibroblast #> PDK4                0.6665598            0.0000000                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.4548868            0.3001104                    0 #> GZMB                0.0000000            0.0000000                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X78_Y-69..Fibroblast X75_Y-69..Fibroblast X76_Y-69..Fibroblast #> PDK4                0.4494522            0.0000000            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.2011935            0.9735436            0.2596922 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X79_Y-69..Fibroblast X76_Y-70..Fibroblast X77_Y-70..Fibroblast #> PDK4                0.5842879                    0            0.4439043 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.2615516                    0            0.1716986 #> GZMB                0.0000000                    0            0.0000000 #> TSC2                0.0000000                    0            0.0000000 #>          X78_Y-70..Fibroblast X77_Y-71..Fibroblast X76_Y-71..Fibroblast #> PDK4                0.2305259            0.5463438            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.7690042            0.5321792            0.5727936 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X78_Y-71..Fibroblast X73_Y-71..Fibroblast X74_Y-71..Fibroblast #> PDK4                0.8901965             0.000000               0.0000 #> TNFRSF17            0.0000000             0.000000               0.0000 #> ICAM3               0.0000000             0.000000               0.0000 #> FAP                 0.4679124             1.365733               2.0486 #> GZMB                0.0000000             0.000000               0.0000 #> TSC2                0.0000000             0.000000               0.0000 #>          X74_Y-72..Fibroblast X75_Y-72..Fibroblast X76_Y-72..Fibroblast #> PDK4                        0            0.2196583            0.0000000 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.4769440            0.2838801 #> GZMB                        0            0.0000000            0.3662093 #> TSC2                        0            0.0000000            0.0000000 #>          X74_Y-68..Fibroblast X56_Y-67..Fibroblast X58_Y-67..Fibroblast #> PDK4                        0              0.00000             0.000000 #> TNFRSF17                    0              0.00000             0.000000 #> ICAM3                       0              0.00000             0.000000 #> FAP                         0              0.00000             1.148884 #> GZMB                        0              0.39886             0.000000 #> TSC2                        0              0.00000             0.000000 #>          X57_Y-67..Fibroblast X60_Y-67..Fibroblast X60_Y-68..Fibroblast #> PDK4                        0            0.0000000            0.0000000 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.9393739            0.7514991 #> GZMB                        0            0.0000000            0.0000000 #> TSC2                        0            0.0000000            0.0000000 #>          X57_Y-68..Fibroblast X58_Y-68..Fibroblast X58_Y-69..Fibroblast #> PDK4                        0            0.0000000            0.0000000 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.9757137            0.9757137 #> GZMB                        0            0.0000000            0.0000000 #> TSC2                        0            0.0000000            0.0000000 #>          X59_Y-70..Fibroblast X60_Y-70..Fibroblast X56_Y-66..Fibroblast #> PDK4                        0            0.8889342             0.000000 #> TNFRSF17                    0            0.0000000             0.000000 #> ICAM3                       0            0.0000000             0.000000 #> FAP                         0            0.0000000             1.132609 #> GZMB                        0            0.0000000             0.000000 #> TSC2                        0            0.8889342             0.000000 #>          X43_Y-79..Fibroblast X47_Y-80..Fibroblast X43_Y-80..Fibroblast #> PDK4                0.2997809             0.000000             0.000000 #> TNFRSF17            0.0000000             0.000000             0.000000 #> ICAM3               0.0000000             0.000000             0.000000 #> FAP                 1.6105204             1.342435             1.809807 #> GZMB                0.6583767             0.000000             0.000000 #> TSC2                0.0000000             0.000000             0.000000 #>          X44_Y-80..Fibroblast X48_Y-80..Fibroblast X46_Y-80..Fibroblast #> PDK4                 0.000000            0.2515534             0.000000 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  2.246676            1.6329134             1.083301 #> GZMB                 0.000000            0.0000000             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X47_Y-81..Fibroblast X45_Y-81..Fibroblast X46_Y-81..Fibroblast #> PDK4                        0            0.7308661             1.461732 #> TNFRSF17                    0            0.0000000             0.000000 #> ICAM3                       0            0.0000000             0.000000 #> FAP                         0            0.0000000             0.000000 #> GZMB                        0            0.0000000             0.000000 #> TSC2                        0            0.0000000             0.000000 #>          X44_Y-81..Fibroblast X45_Y-82..Fibroblast X44_Y-82..Fibroblast #> PDK4                 0.000000                    0            0.6032782 #> TNFRSF17             0.000000                    0            0.0000000 #> ICAM3                0.000000                    0            0.0000000 #> FAP                  3.362905                    0            0.8148402 #> GZMB                 0.000000                    0            0.0000000 #> TSC2                 0.000000                    0            0.0000000 #>          X46_Y-82..Fibroblast X43_Y-82..Fibroblast X46_Y-83..Fibroblast #> PDK4                0.0000000                    0            0.3729684 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.7389220                    0            0.8962852 #> GZMB                0.9178963                    0            0.4589481 #> TSC2                0.0000000                    0            0.0000000 #>          X44_Y-83..Fibroblast X45_Y-83..Fibroblast X43_Y-83..Fibroblast #> PDK4                0.5617966            1.9109444             0.949815 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.9993157            0.6404887             0.000000 #> GZMB                0.0000000            0.4975883             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X43_Y-84..Fibroblast X44_Y-84..Fibroblast X45_Y-84..Fibroblast #> PDK4                0.7697237            0.3151367            0.9268462 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.5225678            0.3718103            0.0000000 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X45_Y-85..Fibroblast X44_Y-85..Fibroblast X51_Y-91..Fibroblast #> PDK4                0.3528194            0.0000000            0.7762752 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.4269925            0.8986848            1.1796943 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X53_Y-91..Fibroblast X49_Y-91..Fibroblast X50_Y-91..Fibroblast #> PDK4                0.5439129             0.000000            0.8662256 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.7725544             1.872375            1.0591172 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.3419928             0.000000            0.0000000 #>          X52_Y-91..Fibroblast X51_Y-92..Fibroblast X50_Y-92..Fibroblast #> PDK4                0.4462001            0.2999502            0.7672848 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.9567266            0.4448220            0.4777005 #> GZMB                0.2232353            0.4448220            0.2516743 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X53_Y-92..Fibroblast X52_Y-92..Fibroblast X49_Y-92..Fibroblast #> PDK4                0.3973663            0.4371029            2.4078075 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.6464128            0.6692002            0.5936471 #> GZMB                0.0000000            0.0000000            0.7550230 #> TSC2                0.2672982            0.0000000            0.0000000 #>          X52_Y-93..Fibroblast X53_Y-93..Fibroblast X51_Y-93..Fibroblast #> PDK4                0.8267396            0.0000000            0.5610106 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.3560442            2.5453356            0.0000000 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.4900467            0.6916996 #>          X54_Y-93..Fibroblast X51_Y-94..Fibroblast X53_Y-94..Fibroblast #> PDK4                 0.723492            0.7012632            0.9585093 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.040855            0.0000000            1.5935985 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.8646246            0.0000000 #>          X50_Y-94..Fibroblast X49_Y-94..Fibroblast X48_Y-95..Fibroblast #> PDK4                        0                    0            1.0759916 #> TNFRSF17                    0                    0            0.0000000 #> ICAM3                       0                    0            0.0000000 #> FAP                         0                    0            0.0000000 #> GZMB                        0                    0            0.0000000 #> TSC2                        0                    0            0.9060609 #>          X52_Y-96..Fibroblast X51_Y-96..Fibroblast X50_Y-96..Fibroblast #> PDK4                0.0000000            0.0000000             1.806465 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.5220731            0.5220731             1.060307 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X53_Y-96..Fibroblast X54_Y-96..Fibroblast X49_Y-96..Fibroblast #> PDK4                0.0000000             0.000000                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 0.9454101             2.724253                    0 #> GZMB                0.0000000             0.000000                    0 #> TSC2                0.0000000             0.000000                    0 #>          X53_Y-97..Fibroblast X52_Y-98..Fibroblast X49_Y-93..Fibroblast #> PDK4                 0.000000              0.00000             1.819280 #> TNFRSF17             0.000000              0.00000             0.000000 #> ICAM3                0.000000              0.00000             0.000000 #> FAP                  1.390121              1.99372             1.187294 #> GZMB                 0.000000              0.00000             1.510046 #> TSC2                 0.000000              0.00000             0.000000 #>          X71_Y-80..Fibroblast X71_Y-81..Fibroblast X71_Y-82..Fibroblast #> PDK4                 1.117071                    0            0.6762172 #> TNFRSF17             0.000000                    0            0.0000000 #> ICAM3                0.000000                    0            0.0000000 #> FAP                  1.117071                    0            0.0000000 #> GZMB                 0.000000                    0            0.0000000 #> TSC2                 0.000000                    0            0.0000000 #>          X67_Y-82..Fibroblast X71_Y-83..Fibroblast X67_Y-83..Fibroblast #> PDK4                        0            0.2704869                    0 #> TNFRSF17                    0            0.0000000                    0 #> ICAM3                       0            0.0000000                    0 #> FAP                         0            0.5014579                    0 #> GZMB                        0            0.0000000                    0 #> TSC2                        0            0.0000000                    0 #>          X70_Y-83..Fibroblast X69_Y-83..Fibroblast X69_Y-84..Fibroblast #> PDK4                0.0000000            0.4371271            1.3166299 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.6536786            0.5602959            0.0000000 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.5715268            1.0081376            0.7255605 #>          X71_Y-84..Fibroblast X67_Y-84..Fibroblast X68_Y-84..Fibroblast #> PDK4                 0.000000            0.0000000            0.5033228 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.092384            1.1080904            1.2522554 #> GZMB                 0.000000            0.5992981            0.0000000 #> TSC2                 0.000000            0.0000000            0.5589164 #>          X72_Y-84..Fibroblast X72_Y-85..Fibroblast X67_Y-85..Fibroblast #> PDK4                0.0000000            0.0000000            0.8432767 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.5077125            0.2976158            0.8432767 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X71_Y-85..Fibroblast X68_Y-85..Fibroblast X72_Y-82..Fibroblast #> PDK4                0.0000000             0.000000                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 0.6422503             2.921929                    0 #> GZMB                0.0000000             0.000000                    0 #> TSC2                0.0000000             0.000000                    0 #>          X70_Y-84..Fibroblast X54_Y-67..Fibroblast X49_Y-67..Fibroblast #> PDK4                 0.000000            1.0191191            0.2942464 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  2.682937            0.0000000            1.1852386 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.6810631            0.0000000 #>          X48_Y-67..Fibroblast X49_Y-68..Fibroblast X52_Y-68..Fibroblast #> PDK4                0.2953210            0.0000000            0.9544500 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.7266446            2.0587828            0.7822726 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.7324082            0.0000000 #>          X50_Y-68..Fibroblast X48_Y-68..Fibroblast X49_Y-69..Fibroblast #> PDK4                0.6520692             0.000000            0.5483535 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.0000000             1.078271            0.0000000 #> GZMB                0.6520692             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.6277785 #>          X50_Y-69..Fibroblast X51_Y-69..Fibroblast X49_Y-70..Fibroblast #> PDK4                0.3009550             0.000000            0.6397457 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.3075199             1.246015            0.5700893 #> GZMB                0.3009550             0.000000            0.7114356 #> TSC2                0.3380346             0.000000            0.0000000 #>          X52_Y-70..Fibroblast X50_Y-70..Fibroblast X51_Y-70..Fibroblast #> PDK4                0.5700893            0.0000000             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 1.2650347            1.2363825             2.024152 #> GZMB                0.0000000            0.7114356             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X53_Y-70..Fibroblast X52_Y-71..Fibroblast X53_Y-71..Fibroblast #> PDK4                 1.056547            0.3871826             1.056547 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  1.167073            0.9297641             1.167073 #> GZMB                 0.000000            0.0000000             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X48_Y-71..Fibroblast X48_Y-72..Fibroblast X53_Y-72..Fibroblast #> PDK4                0.3249031            1.9809592                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.3499046            0.9603879                    0 #> GZMB                0.0000000            1.1145511                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X54_Y-72..Fibroblast X51_Y-68..Fibroblast X52_Y-69..Fibroblast #> PDK4                 0.000000            0.6926802             1.140179 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  1.908245            0.4735860             2.323229 #> GZMB                 0.000000            0.0000000             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X65_Y-64..Fibroblast X63_Y-64..Fibroblast X66_Y-64..Fibroblast #> PDK4                0.0000000            0.6011077            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.5416504            0.7143549            1.0861320 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.4803665 #>          X64_Y-64..Fibroblast X66_Y-65..Fibroblast X65_Y-65..Fibroblast #> PDK4                0.4007385            0.0000000            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.4762366            0.8689056            0.8437246 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.3842932            0.3493575 #>          X64_Y-65..Fibroblast X64_Y-66..Fibroblast X63_Y-65..Fibroblast #> PDK4                0.3278770            0.0000000            0.9016616 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.3896481            1.6681661            1.0715323 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.2804934            0.6170856            0.0000000 #>          X59_Y-79..Fibroblast X58_Y-79..Fibroblast X55_Y-80..Fibroblast #> PDK4                  0.00000            0.4087870            0.0000000 #> TNFRSF17              0.00000            0.0000000            0.0000000 #> ICAM3                 0.00000            0.0000000            0.0000000 #> FAP                   1.01327            0.7880987            0.5555282 #> GZMB                  0.00000            0.0000000            0.6716302 #> TSC2                  0.00000            0.0000000            0.0000000 #>          X59_Y-80..Fibroblast X56_Y-80..Fibroblast X57_Y-80..Fibroblast #> PDK4                0.2830064            0.5734643            0.6881572 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.9725001            0.7068714            1.6760085 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X54_Y-80..Fibroblast X58_Y-80..Fibroblast X60_Y-80..Fibroblast #> PDK4                 1.588185            0.3344621             0.000000 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  0.000000            0.2823246             1.377386 #> GZMB                 1.481016            0.0000000             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X58_Y-81..Fibroblast X59_Y-81..Fibroblast X60_Y-81..Fibroblast #> PDK4                0.4471008            0.2649770            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.1491867            0.5745604            1.1269521 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.3719454 #>          X55_Y-81..Fibroblast X56_Y-81..Fibroblast X57_Y-81..Fibroblast #> PDK4                0.3030154            0.3030154             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 1.6433451            1.0848382             1.874266 #> GZMB                0.3663438            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X58_Y-82..Fibroblast X57_Y-82..Fibroblast X55_Y-82..Fibroblast #> PDK4                0.5102614              0.00000            0.4264987 #> TNFRSF17            0.0000000              0.00000            0.0000000 #> ICAM3               0.0000000              0.00000            0.0000000 #> FAP                 0.9445865              1.18032            1.7989371 #> GZMB                0.0000000              0.00000            0.0000000 #> TSC2                0.0000000              0.00000            0.4016894 #>          X59_Y-82..Fibroblast X56_Y-82..Fibroblast X60_Y-82..Fibroblast #> PDK4                0.4622698             0.000000            0.3992713 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.7030034             1.732932            0.5427514 #> GZMB                0.0000000             0.000000            0.7670026 #> TSC2                0.0000000             0.000000            0.3250838 #>          X56_Y-83..Fibroblast X54_Y-83..Fibroblast X57_Y-83..Fibroblast #> PDK4                 0.369487             0.000000            0.3513646 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  0.000000             1.625002            0.9301167 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X55_Y-83..Fibroblast X58_Y-84..Fibroblast X59_Y-84..Fibroblast #> PDK4                        0            0.7531407                    0 #> TNFRSF17                    0            0.0000000                    0 #> ICAM3                       0            0.0000000                    0 #> FAP                         0            0.5342627                    0 #> GZMB                        0            0.0000000                    0 #> TSC2                        0            0.0000000                    0 #>          X56_Y-84..Fibroblast X57_Y-84..Fibroblast X60_Y-84..Fibroblast #> PDK4                0.7971641                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 0.0000000                    0                    0 #> GZMB                0.0000000                    0                    0 #> TSC2                0.0000000                    0                    0 #>          X54_Y-85..Fibroblast X54_Y-79..Fibroblast X58_Y-83..Fibroblast #> PDK4                  0.94769                    0            0.7697761 #> TNFRSF17              0.00000                    0            0.0000000 #> ICAM3                 0.00000                    0            0.0000000 #> FAP                   0.00000                    0            0.7608086 #> GZMB                  0.00000                    0            0.0000000 #> TSC2                  0.00000                    0            0.0000000 #>          X54_Y-84..Fibroblast X56_Y-85..Fibroblast X65_Y-82..Fibroblast #> PDK4                        0                    0             3.749358 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X62_Y-83..Fibroblast X61_Y-83..Fibroblast X64_Y-83..Fibroblast #> PDK4                        0                    0            0.0000000 #> TNFRSF17                    0                    0            0.0000000 #> ICAM3                       0                    0            0.0000000 #> FAP                         0                    0            0.7033122 #> GZMB                        0                    0            0.3415058 #> TSC2                        0                    0            0.0000000 #>          X63_Y-83..Fibroblast X64_Y-84..Fibroblast X62_Y-84..Fibroblast #> PDK4                0.0000000            0.0000000            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            0.9042585            0.7667927 #> GZMB                0.5122587            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X63_Y-84..Fibroblast X66_Y-84..Fibroblast X65_Y-84..Fibroblast #> PDK4                        0             0.000000            0.6036479 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             1.313656            2.0708715 #> GZMB                        0             0.000000            0.0000000 #> TSC2                        0             0.000000            0.0000000 #>          X62_Y-85..Fibroblast X61_Y-85..Fibroblast X60_Y-83..Fibroblast #> PDK4                0.6060952            0.3527584            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            1.5277791            0.0000000 #> GZMB                0.0000000            0.0000000            1.7896728 #> TSC2                0.0000000            0.0000000            0.7585288 #>          X61_Y-84..Fibroblast X32_Y-91..Fibroblast X34_Y-91..Fibroblast #> PDK4                        0            0.4913859            0.0000000 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.5975760            0.7136374 #> GZMB                        0            0.0000000            0.7136374 #> TSC2                        0            0.0000000            0.0000000 #>          X31_Y-91..Fibroblast X33_Y-91..Fibroblast X36_Y-91..Fibroblast #> PDK4                0.0000000                    0            0.4007385 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.5121273                    0            1.1374998 #> GZMB                0.0000000                    0            0.0000000 #> TSC2                0.0000000                    0            0.0000000 #>          X32_Y-92..Fibroblast X31_Y-92..Fibroblast X33_Y-92..Fibroblast #> PDK4                0.2330316            0.8620521             1.031685 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 1.1063139            0.2295977             1.202947 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.2686050            0.1939925             0.000000 #>          X34_Y-92..Fibroblast X30_Y-92..Fibroblast X32_Y-93..Fibroblast #> PDK4                 1.492061             1.403311            0.0000000 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  0.000000             0.000000            1.4181108 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.4364831 #>          X31_Y-93..Fibroblast X34_Y-93..Fibroblast X35_Y-93..Fibroblast #> PDK4                0.6927086            0.4607720            0.6748139 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.3530923            0.4895181            0.2771153 #> GZMB                0.0000000            0.0000000            0.2771153 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X33_Y-93..Fibroblast X36_Y-93..Fibroblast X31_Y-94..Fibroblast #> PDK4                0.4331234            0.4589481            0.4468283 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 2.0740310            0.8601333            0.7735926 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X34_Y-94..Fibroblast X35_Y-94..Fibroblast X33_Y-94..Fibroblast #> PDK4                0.7679533            1.0085632             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.4264971            0.3824862             2.252535 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X36_Y-94..Fibroblast X32_Y-95..Fibroblast X36_Y-95..Fibroblast #> PDK4                 1.141536            0.6559976            0.4034861 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.022994            0.7908283            0.8408755 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X33_Y-95..Fibroblast X31_Y-95..Fibroblast X35_Y-95..Fibroblast #> PDK4                        0             0.000000             0.000000 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             0.577829             1.415694 #> GZMB                        0             0.000000             0.000000 #> TSC2                        0             0.000000             0.000000 #>          X34_Y-95..Fibroblast X29_Y-95..Fibroblast X33_Y-96..Fibroblast #> PDK4                        0                    0             0.724693 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X31_Y-96..Fibroblast X35_Y-96..Fibroblast X32_Y-96..Fibroblast #> PDK4                 1.049159                    0             0.000000 #> TNFRSF17             0.000000                    0             0.000000 #> ICAM3                0.000000                    0             0.000000 #> FAP                  2.050605                    0             2.003961 #> GZMB                 0.000000                    0             0.000000 #> TSC2                 0.000000                    0             0.000000 #>          X30_Y-96..Fibroblast X34_Y-96..Fibroblast X30_Y-97..Fibroblast #> PDK4                0.9860738                    0             1.362828 #> TNFRSF17            0.0000000                    0             0.000000 #> ICAM3               0.0000000                    0             0.000000 #> FAP                 2.1868740                    0             2.651363 #> GZMB                0.0000000                    0             0.000000 #> TSC2                0.0000000                    0             0.000000 #>          X31_Y-97..Fibroblast X33_Y-97..Fibroblast X35_Y-97..Fibroblast #> PDK4                0.9860738            1.2081524             1.012045 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 1.5122415            0.6371141             1.949802 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X34_Y-97..Fibroblast X36_Y-97..Fibroblast X30_Y-98..Fibroblast #> PDK4                0.7246930             0.650885            0.0000000 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.7432998             1.519027            0.7938623 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.0000000 #>          X35_Y-98..Fibroblast X35_Y-91..Fibroblast X35_Y-92..Fibroblast #> PDK4                0.7109386            0.5292989            0.3803539 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.3185725            0.8006961            0.8513111 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X36_Y-92..Fibroblast X32_Y-97..Fibroblast X48_Y-85..Fibroblast #> PDK4                 1.612226              0.00000             3.091379 #> TNFRSF17             0.000000              0.00000             0.000000 #> ICAM3                0.000000              0.00000             0.000000 #> FAP                  1.067072              1.29937             0.000000 #> GZMB                 0.000000              0.00000             0.000000 #> TSC2                 0.000000              0.00000             0.000000 #>          X42_Y-86..Fibroblast X45_Y-86..Fibroblast X44_Y-86..Fibroblast #> PDK4                        0            0.0000000            0.0000000 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.2779782            1.1642710 #> GZMB                        0            0.0000000            0.3481473 #> TSC2                        0            0.0000000            0.0000000 #>          X47_Y-86..Fibroblast X43_Y-86..Fibroblast X44_Y-87..Fibroblast #> PDK4                0.9530384                    0            0.8519318 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.7810218                    0            0.3965608 #> GZMB                0.0000000                    0            0.3973081 #> TSC2                0.0000000                    0            0.0000000 #>          X45_Y-87..Fibroblast X47_Y-87..Fibroblast X46_Y-88..Fibroblast #> PDK4                0.8218521            0.6404887             3.131032 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.5305546            1.9234846             0.000000 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X47_Y-88..Fibroblast X44_Y-88..Fibroblast X45_Y-88..Fibroblast #> PDK4                0.9316851            0.4898801            1.1422085 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.6195601            0.9571056            0.2767914 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.3826947            0.0000000            0.0000000 #>          X48_Y-88..Fibroblast X47_Y-89..Fibroblast X44_Y-89..Fibroblast #> PDK4                0.1799321            0.5327118            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.5533490            1.6696563            0.9829564 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X48_Y-89..Fibroblast X45_Y-89..Fibroblast X46_Y-89..Fibroblast #> PDK4                 0.000000             0.348282             0.000000 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  2.436306             1.559988             1.502301 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             0.000000 #>          X42_Y-89..Fibroblast X45_Y-90..Fibroblast X46_Y-90..Fibroblast #> PDK4                  0.00000             0.000000            0.5921766 #> TNFRSF17              0.00000             0.000000            0.0000000 #> ICAM3                 0.00000             0.000000            0.0000000 #> FAP                   1.84332             2.436767            2.2945924 #> GZMB                  0.00000             0.000000            0.0000000 #> TSC2                  0.00000             0.000000            0.0000000 #>          X44_Y-90..Fibroblast X48_Y-90..Fibroblast X47_Y-90..Fibroblast #> PDK4                0.0000000            0.0000000            0.3874268 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.5739525            0.5654759            0.7967354 #> GZMB                0.6082402            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X43_Y-90..Fibroblast X42_Y-90..Fibroblast X47_Y-91..Fibroblast #> PDK4                0.4810974            0.0000000             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 1.1636225            0.7624308             1.580059 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X45_Y-91..Fibroblast X48_Y-91..Fibroblast X50_Y-80..Fibroblast #> PDK4                        0                    0            0.8307005 #> TNFRSF17                    0                    0            0.0000000 #> ICAM3                       0                    0            0.0000000 #> FAP                         0                    0            0.0000000 #> GZMB                        0                    0            0.8537074 #> TSC2                        0                    0            0.0000000 #>          X51_Y-80..Fibroblast X52_Y-80..Fibroblast X52_Y-81..Fibroblast #> PDK4                 0.000000             0.000000            0.0000000 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  1.919656             1.578154            0.8006046 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X49_Y-80..Fibroblast X50_Y-81..Fibroblast X53_Y-81..Fibroblast #> PDK4                 0.000000            0.4746860            0.9494038 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.000000            0.0000000            0.9775673 #> GZMB                 0.000000            0.4878328            0.0000000 #> TSC2                 1.531839            0.0000000            0.0000000 #>          X49_Y-81..Fibroblast X51_Y-81..Fibroblast X54_Y-81..Fibroblast #> PDK4                0.9864785            0.0000000             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.0000000            1.1344363             2.375059 #> GZMB                0.0000000            0.5691383             0.000000 #> TSC2                0.6565023            0.0000000             0.000000 #>          X53_Y-82..Fibroblast X51_Y-82..Fibroblast X50_Y-82..Fibroblast #> PDK4                0.6645827                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 1.0051916                    0                    0 #> GZMB                0.0000000                    0                    0 #> TSC2                0.0000000                    0                    0 #>          X54_Y-82..Fibroblast X53_Y-83..Fibroblast X50_Y-83..Fibroblast #> PDK4                 0.781542             1.268855            0.5470754 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  1.457345             1.267023            1.0396900 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X51_Y-83..Fibroblast X52_Y-83..Fibroblast X51_Y-84..Fibroblast #> PDK4                 1.032663            0.0000000            1.0849612 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.636216            0.0000000            0.5965257 #> GZMB                 0.000000            0.7291601            0.0000000 #> TSC2                 0.000000            0.0000000            0.5794252 #>          X52_Y-84..Fibroblast X53_Y-84..Fibroblast X52_Y-85..Fibroblast #> PDK4                0.0000000            0.0000000            0.8899950 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.7989342            0.8745151            0.8808254 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X53_Y-85..Fibroblast X53_Y-80..Fibroblast X71_Y-91..Fibroblast #> PDK4                0.8385641            0.0000000            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.8385641            0.8523389            0.6993181 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X70_Y-91..Fibroblast X69_Y-91..Fibroblast X71_Y-92..Fibroblast #> PDK4                 0.000000            0.0000000            0.3846092 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.495581            0.4769423            0.3446119 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X70_Y-92..Fibroblast X69_Y-92..Fibroblast X73_Y-92..Fibroblast #> PDK4                0.6686247            0.0000000                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.0000000            0.5909636                    0 #> GZMB                0.0000000            0.0000000                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X72_Y-92..Fibroblast X69_Y-93..Fibroblast X67_Y-93..Fibroblast #> PDK4                0.0000000            0.0000000            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.4756353            0.4686697            0.0000000 #> GZMB                0.0000000            0.4990655            0.6797361 #> TSC2                0.2298649            0.0000000            0.0000000 #>          X71_Y-93..Fibroblast X72_Y-93..Fibroblast X68_Y-93..Fibroblast #> PDK4                        0            0.3484487            0.0000000 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.5122226            0.5263264 #> GZMB                        0            0.0000000            0.6654206 #> TSC2                        0            0.2475468            0.0000000 #>          X70_Y-93..Fibroblast X72_Y-94..Fibroblast X69_Y-94..Fibroblast #> PDK4                        0            0.5662292            0.0000000 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.3892193            0.5311957 #> GZMB                        0            0.0000000            0.0000000 #> TSC2                        0            0.0000000            0.0000000 #>          X68_Y-94..Fibroblast X70_Y-94..Fibroblast X73_Y-94..Fibroblast #> PDK4                0.0000000                    0            0.4682882 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.6108193                    0            0.0000000 #> GZMB                0.0000000                    0            0.4682882 #> TSC2                0.0000000                    0            0.0000000 #>          X67_Y-94..Fibroblast X69_Y-95..Fibroblast X72_Y-95..Fibroblast #> PDK4                0.0000000            0.0000000                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.6828667            0.5843153                    0 #> GZMB                0.4531574            0.0000000                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X71_Y-95..Fibroblast X68_Y-95..Fibroblast X70_Y-95..Fibroblast #> PDK4                0.3246152            0.2694161                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.0000000            0.5854707                    0 #> GZMB                0.0000000            0.0000000                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X71_Y-96..Fibroblast X72_Y-96..Fibroblast X69_Y-96..Fibroblast #> PDK4                0.3318059            0.0000000             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.2470356            0.8997735             1.425194 #> GZMB                0.0000000            1.2226195             0.000000 #> TSC2                0.0000000            0.9198535             0.000000 #>          X70_Y-96..Fibroblast X71_Y-97..Fibroblast X72_Y-97..Fibroblast #> PDK4                        0            0.5024364            0.0000000 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.0000000            0.3375975 #> GZMB                        0            0.0000000            0.0000000 #> TSC2                        0            0.0000000            0.0000000 #>          X70_Y-97..Fibroblast X68_Y-97..Fibroblast X66_Y-92..Fibroblast #> PDK4                  1.14396             0.000000                    0 #> TNFRSF17              0.00000             0.000000                    0 #> ICAM3                 0.00000             0.000000                    0 #> FAP                   0.00000             2.503386                    0 #> GZMB                  0.00000             0.000000                    0 #> TSC2                  0.00000             0.000000                    0 #>          X68_Y-92..Fibroblast X73_Y-93..Fibroblast X71_Y-94..Fibroblast #> PDK4                        0            0.3010424                    0 #> TNFRSF17                    0            0.0000000                    0 #> ICAM3                       0            0.0000000                    0 #> FAP                         0            0.2848084                    0 #> GZMB                        0            0.3010424                    0 #> TSC2                        0            0.0000000                    0 #>          X69_Y-97..Fibroblast X69_Y-98..Fibroblast X25_Y-64..Fibroblast #> PDK4                 0.000000            0.0000000             1.205574 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  2.232814            0.6528176             0.000000 #> GZMB                 0.000000            0.0000000             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X27_Y-64..Fibroblast X27_Y-65..Fibroblast X26_Y-65..Fibroblast #> PDK4                1.9412647            0.7335717            0.5956675 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.8300571            1.4213533            0.0000000 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X25_Y-65..Fibroblast X28_Y-65..Fibroblast X24_Y-65..Fibroblast #> PDK4                0.5956675                    0            0.7052915 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.0000000                    0            0.0000000 #> GZMB                0.0000000                    0            0.0000000 #> TSC2                0.0000000                    0            0.0000000 #>          X26_Y-66..Fibroblast X28_Y-66..Fibroblast X27_Y-66..Fibroblast #> PDK4                        0            0.6036479                    0 #> TNFRSF17                    0            0.0000000                    0 #> ICAM3                       0            0.0000000                    0 #> FAP                         0            0.0000000                    0 #> GZMB                        0            0.6445448                    0 #> TSC2                        0            0.0000000                    0 #>          X26_Y-64..Fibroblast X29_Y-65..Fibroblast X77_Y-92..Fibroblast #> PDK4                0.8339345             3.988079            0.5890774 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.0000000             0.000000            1.5538205 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.0000000 #>          X76_Y-92..Fibroblast X75_Y-92..Fibroblast X78_Y-92..Fibroblast #> PDK4                        0             0.000000            0.0000000 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             1.335811            0.0000000 #> GZMB                        0             0.000000            0.9230241 #> TSC2                        0             0.000000            0.0000000 #>          X74_Y-92..Fibroblast X75_Y-93..Fibroblast X76_Y-93..Fibroblast #> PDK4                        0            0.0000000            0.0000000 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.3583345            0.2815486 #> GZMB                        0            0.0000000            0.0000000 #> TSC2                        0            0.0000000            0.0000000 #>          X78_Y-93..Fibroblast X74_Y-93..Fibroblast X77_Y-93..Fibroblast #> PDK4                0.0000000            0.0000000                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.8379783            0.2646145                    0 #> GZMB                0.4364831            0.0000000                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X75_Y-94..Fibroblast X78_Y-94..Fibroblast X74_Y-94..Fibroblast #> PDK4                0.0000000            0.0000000            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.9957762            0.9450024            0.9809143 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X77_Y-94..Fibroblast X76_Y-95..Fibroblast X78_Y-95..Fibroblast #> PDK4                 1.027964             0.000000                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  0.000000             2.666444                    0 #> GZMB                 0.000000             0.000000                    0 #> TSC2                 0.000000             0.000000                    0 #>          X75_Y-95..Fibroblast X75_Y-96..Fibroblast X78_Y-96..Fibroblast #> PDK4                 0.000000            0.0000000                    0 #> TNFRSF17             0.000000            0.0000000                    0 #> ICAM3                0.000000            0.0000000                    0 #> FAP                  1.517629            0.9177349                    0 #> GZMB                 0.000000            0.5921297                    0 #> TSC2                 0.000000            0.0000000                    0 #>          X76_Y-96..Fibroblast X79_Y-96..Fibroblast X74_Y-96..Fibroblast #> PDK4                 0.000000                    0                    0 #> TNFRSF17             0.000000                    0                    0 #> ICAM3                0.000000                    0                    0 #> FAP                  1.241289                    0                    0 #> GZMB                 0.000000                    0                    0 #> TSC2                 0.000000                    0                    0 #>          X78_Y-97..Fibroblast X76_Y-94..Fibroblast X79_Y-94..Fibroblast #> PDK4                        0             1.202215             0.000000 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             0.000000             1.181253 #> GZMB                        0             0.000000             0.000000 #> TSC2                        0             0.000000             0.000000 #>          X73_Y-95..Fibroblast X74_Y-95..Fibroblast X77_Y-95..Fibroblast #> PDK4                 0.000000            0.0000000             0.000000 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  0.000000            0.6484216             1.341457 #> GZMB                 1.944345            0.6665598             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X77_Y-96..Fibroblast X77_Y-97..Fibroblast X43_Y-67..Fibroblast #> PDK4                 0.000000            0.0000000             1.200953 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  1.341457            0.5101034             1.019397 #> GZMB                 0.000000            0.0000000             0.000000 #> TSC2                 1.016752            0.0000000             0.000000 #>          X45_Y-67..Fibroblast X45_Y-68..Fibroblast X47_Y-68..Fibroblast #> PDK4                0.9955428            0.6958559            1.2983444 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 2.0349010            1.4200076            0.8721409 #> GZMB                0.2337544            0.2337544            0.0000000 #> TSC2                0.3682038            0.3682038            0.0000000 #>          X43_Y-68..Fibroblast X46_Y-68..Fibroblast X44_Y-68..Fibroblast #> PDK4                0.8252197            0.0000000             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 1.0036491            0.5984861             1.497411 #> GZMB                0.0000000            0.3605435             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X43_Y-69..Fibroblast X44_Y-69..Fibroblast X46_Y-69..Fibroblast #> PDK4                 0.000000            0.3987317            0.3417245 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.608985            0.7592822            0.7538191 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.3351594            0.0000000 #>          X48_Y-69..Fibroblast X47_Y-69..Fibroblast X45_Y-69..Fibroblast #> PDK4                0.0000000            0.5606847            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.3397727            0.0000000            0.6255697 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X47_Y-70..Fibroblast X46_Y-70..Fibroblast X45_Y-70..Fibroblast #> PDK4                0.9018725             0.000000            0.0000000 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 1.1547720             1.839533            0.7093350 #> GZMB                0.0000000             0.000000            0.3769273 #> TSC2                0.0000000             0.000000            0.0000000 #>          X44_Y-70..Fibroblast X43_Y-70..Fibroblast X43_Y-71..Fibroblast #> PDK4                0.0000000            1.1786316            0.7539529 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.7644185            0.6717718            1.4266404 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.2745421            0.2745421 #>          X44_Y-71..Fibroblast X45_Y-71..Fibroblast X46_Y-71..Fibroblast #> PDK4                 1.321588                    0              0.00000 #> TNFRSF17             0.000000                    0              0.00000 #> ICAM3                0.000000                    0              0.00000 #> FAP                  1.474175                    0              1.26365 #> GZMB                 0.000000                    0              0.00000 #> TSC2                 0.000000                    0              0.00000 #>          X47_Y-71..Fibroblast X46_Y-72..Fibroblast X42_Y-72..Fibroblast #> PDK4                        0              0.00000            0.5585990 #> TNFRSF17                    0              0.00000            0.0000000 #> ICAM3                       0              0.00000            0.0000000 #> FAP                         0              1.16572            0.6368079 #> GZMB                        0              0.00000            0.0000000 #> TSC2                        0              0.00000            0.0000000 #>          X48_Y-70..Fibroblast X74_Y-64..Fibroblast X73_Y-65..Fibroblast #> PDK4                   1.8975            0.7065772            0.8832215 #> TNFRSF17               0.0000            0.0000000            0.0000000 #> ICAM3                  0.0000            0.0000000            0.0000000 #> FAP                    0.0000            0.0000000            0.0000000 #> GZMB                   0.0000            0.7085223            0.0000000 #> TSC2                   0.0000            0.0000000            0.0000000 #>          X78_Y-65..Fibroblast X74_Y-65..Fibroblast X77_Y-66..Fibroblast #> PDK4                 0.000000            0.3532886                    0 #> TNFRSF17             0.000000            0.0000000                    0 #> ICAM3                0.000000            0.0000000                    0 #> FAP                  0.606633            0.3847411                    0 #> GZMB                 0.000000            0.3542611                    0 #> TSC2                 0.000000            0.0000000                    0 #>          X22_Y-91..Fibroblast X22_Y-92..Fibroblast X22_Y-93..Fibroblast #> PDK4                 0.000000                    0            1.2601084 #> TNFRSF17             0.000000                    0            0.0000000 #> ICAM3                0.000000                    0            0.0000000 #> FAP                  4.660719                    0            0.6550156 #> GZMB                 0.000000                    0            0.0000000 #> TSC2                 0.000000                    0            0.0000000 #>          X22_Y-94..Fibroblast X23_Y-94..Fibroblast X22_Y-95..Fibroblast #> PDK4                0.5491457            0.8237186            0.4706963 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.2471737            1.8707605            1.1141331 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X23_Y-95..Fibroblast X23_Y-96..Fibroblast X22_Y-96..Fibroblast #> PDK4                 0.000000            0.9275778            0.0000000 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.765924            0.4743751            0.4319404 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X22_Y-97..Fibroblast X23_Y-86..Fibroblast X25_Y-86..Fibroblast #> PDK4                0.3846092            0.9220365             1.176555 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.3839470            0.0000000             0.000000 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X24_Y-86..Fibroblast X23_Y-87..Fibroblast X24_Y-87..Fibroblast #> PDK4                0.8537227             1.202215            0.4742904 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.0000000             0.000000            0.4390707 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.0000000 #>          X26_Y-87..Fibroblast X25_Y-87..Fibroblast X28_Y-88..Fibroblast #> PDK4                0.2396778            0.3557178            1.8343112 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.6164890            0.3293030            0.2924386 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X27_Y-88..Fibroblast X25_Y-88..Fibroblast X26_Y-88..Fibroblast #> PDK4                 2.190897            0.5643814            0.6529418 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.000000            0.6240395            0.9710765 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.3662041            0.0000000 #>          X27_Y-89..Fibroblast X28_Y-89..Fibroblast X26_Y-89..Fibroblast #> PDK4                0.0000000            0.4909384            1.4927736 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.6404887            0.4578623            0.9351866 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X24_Y-89..Fibroblast X27_Y-90..Fibroblast X28_Y-90..Fibroblast #> PDK4                0.6100748                    0            0.7013413 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 2.7904740                    0            0.0000000 #> GZMB                0.0000000                    0            0.0000000 #> TSC2                0.0000000                    0            0.0000000 #>          X24_Y-90..Fibroblast X23_Y-91..Fibroblast X29_Y-91..Fibroblast #> PDK4                0.4580956             1.060771            0.0000000 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 1.7025178             1.319003            0.6402472 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.0000000 #>          X24_Y-88..Fibroblast X29_Y-88..Fibroblast X25_Y-89..Fibroblast #> PDK4                  0.00000            0.7721949            0.0000000 #> TNFRSF17              0.00000            0.0000000            0.0000000 #> ICAM3                 0.00000            0.0000000            0.0000000 #> FAP                   1.84522            0.8773159            0.6169894 #> GZMB                  0.00000            0.0000000            0.0000000 #> TSC2                  0.00000            0.0000000            0.0000000 #>          X23_Y-89..Fibroblast X25_Y-90..Fibroblast X33_Y-85..Fibroblast #> PDK4                 1.502472             0.000000            0.2527525 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  2.311363             1.388847            0.0000000 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X34_Y-85..Fibroblast X36_Y-85..Fibroblast X35_Y-86..Fibroblast #> PDK4                0.5594877            0.4031616            0.2908975 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.2210073            0.0000000            0.9772639 #> GZMB                0.0000000            0.4177742            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X34_Y-86..Fibroblast X36_Y-86..Fibroblast X33_Y-86..Fibroblast #> PDK4                0.8195374            0.0000000            0.9540838 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.1274096            0.7239327            0.0000000 #> GZMB                0.4639960            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X33_Y-87..Fibroblast X34_Y-87..Fibroblast X35_Y-87..Fibroblast #> PDK4                 1.064954                    0                    0 #> TNFRSF17             0.000000                    0                    0 #> ICAM3                0.000000                    0                    0 #> FAP                  0.000000                    0                    0 #> GZMB                 0.000000                    0                    0 #> TSC2                 0.000000                    0                    0 #>          X36_Y-88..Fibroblast X33_Y-88..Fibroblast X34_Y-88..Fibroblast #> PDK4                0.0000000            0.5835165            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.8442717            0.5460596            0.5939217 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.2893768            0.0000000 #>          X35_Y-88..Fibroblast X33_Y-89..Fibroblast X34_Y-89..Fibroblast #> PDK4                        0            0.3361899            0.9353221 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.0000000            0.4882721 #> GZMB                        0            0.0000000            0.0000000 #> TSC2                        0            0.3946047            0.0000000 #>          X35_Y-89..Fibroblast X33_Y-90..Fibroblast X34_Y-90..Fibroblast #> PDK4                 0.773358             1.121304            1.0503018 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  2.216575             0.000000            0.7324082 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X36_Y-90..Fibroblast X35_Y-90..Fibroblast X32_Y-87..Fibroblast #> PDK4                0.6131804             0.000000             1.138487 #> TNFRSF17            0.0000000             0.000000             0.000000 #> ICAM3               0.0000000             0.000000             0.000000 #> FAP                 1.3586549             1.069596             0.000000 #> GZMB                0.0000000             0.000000             0.000000 #> TSC2                0.0000000             0.000000             0.000000 #>          X32_Y-88..Fibroblast X36_Y-89..Fibroblast X32_Y-90..Fibroblast #> PDK4                 0.000000            0.3733287             1.070299 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  1.170128            0.4062903             0.000000 #> GZMB                 0.000000            0.0000000             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X40_Y-85..Fibroblast X39_Y-85..Fibroblast X41_Y-86..Fibroblast #> PDK4                 1.461681            0.0000000            0.7983858 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.354968            0.8609287            0.0000000 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.4234501 #>          X37_Y-86..Fibroblast X40_Y-86..Fibroblast X40_Y-87..Fibroblast #> PDK4                 0.000000             0.000000             0.000000 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  1.739261             3.551787             2.009987 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             0.000000 #>          X41_Y-87..Fibroblast X36_Y-87..Fibroblast X39_Y-88..Fibroblast #> PDK4                  0.00000             0.000000             0.000000 #> TNFRSF17              0.00000             0.000000             0.000000 #> ICAM3                 0.00000             0.000000             0.000000 #> FAP                   1.01568             1.688543             1.745743 #> GZMB                  0.00000             0.000000             0.000000 #> TSC2                  0.00000             0.000000             0.000000 #>          X40_Y-88..Fibroblast X38_Y-88..Fibroblast X41_Y-88..Fibroblast #> PDK4                0.3514126            0.9087402            0.9722598 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 2.3713854            0.7495276            2.1163279 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.3906175            0.0000000            0.0000000 #>          X39_Y-89..Fibroblast X38_Y-89..Fibroblast X37_Y-89..Fibroblast #> PDK4                  0.00000            1.4628087            0.7254463 #> TNFRSF17              0.00000            0.0000000            0.0000000 #> ICAM3                 0.00000            0.0000000            0.0000000 #> FAP                   1.44639            0.0000000            0.4514337 #> GZMB                  0.00000            0.0000000            0.0000000 #> TSC2                  0.00000            0.8565202            0.0000000 #>          X41_Y-89..Fibroblast X40_Y-89..Fibroblast X39_Y-90..Fibroblast #> PDK4                0.7608781             0.000000            0.4439977 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.3430469             1.951116            0.7020623 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.4774214             0.000000            0.0000000 #>          X41_Y-90..Fibroblast X40_Y-90..Fibroblast X37_Y-90..Fibroblast #> PDK4                0.8002945            0.0000000            0.8512150 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.9082579            0.6962301            0.5128796 #> GZMB                0.2630610            0.0000000            0.4257918 #> TSC2                0.2581176            0.0000000            0.0000000 #>          X38_Y-90..Fibroblast X39_Y-91..Fibroblast X40_Y-91..Fibroblast #> PDK4                0.0000000            0.3898331            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.8206074            0.3679269            0.9841066 #> GZMB                0.0000000            0.1670511            0.3301969 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X38_Y-91..Fibroblast X41_Y-91..Fibroblast X34_Y-98..Fibroblast #> PDK4                0.3291544            0.2258529            0.4436138 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.3730033            0.9088774            0.9396309 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.2258529            0.0000000 #>          X29_Y-98..Fibroblast X33_Y-98..Fibroblast X32_Y-98..Fibroblast #> PDK4                 0.000000            0.0000000            0.8359921 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.984656            0.7531407            1.2612984 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X31_Y-98..Fibroblast X31_Y-99..Fibroblast X35_Y-99..Fibroblast #> PDK4                0.8339345                    0             0.000000 #> TNFRSF17            0.0000000                    0             0.000000 #> ICAM3               0.0000000                    0             0.000000 #> FAP                 0.6390740                    0             1.587004 #> GZMB                0.0000000                    0             0.000000 #> TSC2                0.0000000                    0             0.000000 #>          X32_Y-99..Fibroblast X33_Y-99..Fibroblast X34_Y-99..Fibroblast #> PDK4                0.7346836            0.6565023            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.9068471            0.9601688            0.6609866 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.2618093            0.4862172            0.0000000 #>          X30_Y-99..Fibroblast X32_Y-100..Fibroblast X33_Y-100..Fibroblast #> PDK4                 1.714302             0.7023254             0.4595516 #> TNFRSF17             0.000000             0.0000000             0.0000000 #> ICAM3                0.000000             0.0000000             0.0000000 #> FAP                  1.278012             1.2066830             0.7876074 #> GZMB                 0.000000             0.0000000             0.0000000 #> TSC2                 0.000000             0.0000000             0.3403520 #>          X35_Y-100..Fibroblast X31_Y-100..Fibroblast X29_Y-100..Fibroblast #> PDK4                 0.4124863             0.8356205              0.000000 #> TNFRSF17             0.0000000             0.0000000              0.000000 #> ICAM3                0.0000000             0.0000000              0.000000 #> FAP                  1.4176363             0.0000000              1.232696 #> GZMB                 0.0000000             0.0000000              0.000000 #> TSC2                 0.0000000             0.0000000              0.000000 #>          X36_Y-100..Fibroblast X34_Y-100..Fibroblast X32_Y-101..Fibroblast #> PDK4                  1.250693              0.000000              1.067077 #> TNFRSF17              0.000000              0.000000              0.000000 #> ICAM3                 0.000000              0.000000              0.000000 #> FAP                   1.788182              0.527648              1.142526 #> GZMB                  0.000000              0.000000              0.000000 #> TSC2                  0.000000              0.000000              0.000000 #>          X31_Y-101..Fibroblast X34_Y-101..Fibroblast X35_Y-101..Fibroblast #> PDK4                 1.3732896             0.3518295                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.7137668             0.3569942                     0 #> GZMB                 0.0000000             0.0000000                     0 #> TSC2                 0.6473359             0.0000000                     0 #>          X36_Y-102..Fibroblast X34_Y-102..Fibroblast X30_Y-102..Fibroblast #> PDK4                  1.652467             0.4837656                     0 #> TNFRSF17              0.000000             0.0000000                     0 #> ICAM3                 0.000000             0.0000000                     0 #> FAP                   2.559910             0.5092751                     0 #> GZMB                  0.000000             0.0000000                     0 #> TSC2                  0.000000             0.0000000                     0 #>          X33_Y-102..Fibroblast X31_Y-102..Fibroblast X33_Y-103..Fibroblast #> PDK4                  0.000000              1.414747             0.7705019 #> TNFRSF17              0.000000              0.000000             0.0000000 #> ICAM3                 0.000000              0.000000             0.0000000 #> FAP                   1.153877              0.000000             0.9705374 #> GZMB                  0.000000              0.000000             0.0000000 #> TSC2                  0.000000              0.000000             0.0000000 #>          X30_Y-103..Fibroblast X31_Y-103..Fibroblast X34_Y-103..Fibroblast #> PDK4                 0.0000000             0.6887931             0.5650348 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.0000000             0.4962571 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.6540389             0.5450324             0.0000000 #>          X32_Y-103..Fibroblast X29_Y-103..Fibroblast X35_Y-104..Fibroblast #> PDK4                  0.000000             0.6677265              0.000000 #> TNFRSF17              0.000000             0.0000000              0.000000 #> ICAM3                 0.000000             0.0000000              0.000000 #> FAP                   1.415887             1.0687077              1.158781 #> GZMB                  0.000000             0.0000000              0.000000 #> TSC2                  0.000000             0.0000000              0.000000 #>          X34_Y-104..Fibroblast X32_Y-104..Fibroblast X36_Y-98..Fibroblast #> PDK4                 0.0000000             0.0000000            0.5561984 #> TNFRSF17             0.0000000             0.0000000            0.0000000 #> ICAM3                0.0000000             0.0000000            0.0000000 #> FAP                  0.8270951             0.5019615            0.7548003 #> GZMB                 0.0000000             0.0000000            0.0000000 #> TSC2                 0.0000000             0.0000000            0.0000000 #>          X33_Y-101..Fibroblast X35_Y-103..Fibroblast X22_Y-86..Fibroblast #> PDK4                 0.0000000              0.000000            1.2216020 #> TNFRSF17             0.0000000              0.000000            0.0000000 #> ICAM3                0.0000000              0.000000            0.0000000 #> FAP                  0.7853872              1.545042            0.6098019 #> GZMB                 0.0000000              0.000000            0.0000000 #> TSC2                 0.0000000              0.000000            0.0000000 #>          X22_Y-87..Fibroblast X23_Y-88..Fibroblast X23_Y-90..Fibroblast #> PDK4                 1.021137             0.000000             1.412100 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  1.410842             1.263587             1.028333 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             0.000000 #>          X22_Y-88..Fibroblast X23_Y-65..Fibroblast X22_Y-65..Fibroblast #> PDK4                        0             2.559166                    0 #> TNFRSF17                    0             0.000000                    0 #> ICAM3                       0             0.000000                    0 #> FAP                         0             0.000000                    0 #> GZMB                        0             0.000000                    0 #> TSC2                        0             0.000000                    0 #>          X23_Y-98..Fibroblast X22_Y-98..Fibroblast X23_Y-99..Fibroblast #> PDK4                        0            0.4902589            0.8942256 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.0000000            0.6368415 #> GZMB                        0            0.0000000            0.0000000 #> TSC2                        0            0.4902589            0.0000000 #>          X23_Y-100..Fibroblast X22_Y-100..Fibroblast X23_Y-101..Fibroblast #> PDK4                 0.6990299                     0             1.0474466 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.9404308                     0             0.5780186 #> GZMB                 0.0000000                     0             0.0000000 #> TSC2                 0.2489430                     0             0.2489430 #>          X24_Y-101..Fibroblast X22_Y-101..Fibroblast X21_Y-102..Fibroblast #> PDK4                 1.2358184             0.8270086             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.3359787             0.3627803             0.7477251 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.3319241             0.0000000             0.0000000 #>          X22_Y-102..Fibroblast X23_Y-102..Fibroblast X22_Y-103..Fibroblast #> PDK4                 0.4543701             0.0000000             0.5948412 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.3738625             0.4984834             0.5948412 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X23_Y-103..Fibroblast X23_Y-104..Fibroblast X22_Y-104..Fibroblast #> PDK4                 0.4085632             0.0000000             0.6528718 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.3642174             0.7040090             0.0000000 #> GZMB                 0.0000000             0.3917231             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X22_Y-99..Fibroblast X21_Y-99..Fibroblast X27_Y-97..Fibroblast #> PDK4                0.5602959            0.7844143                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.4548868            0.0000000                    0 #> GZMB                0.0000000            0.0000000                    0 #> TSC2                0.5602959            0.7844143                    0 #>          X25_Y-98..Fibroblast X28_Y-98..Fibroblast X26_Y-99..Fibroblast #> PDK4                0.8853154            0.6622551            0.6899201 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.5317823            1.3567850            0.0000000 #> GZMB                0.8523389            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X29_Y-99..Fibroblast X25_Y-99..Fibroblast X28_Y-99..Fibroblast #> PDK4                 1.791880            1.4089615             2.663701 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  2.259907            0.9143074             0.000000 #> GZMB                 0.000000            0.4619123             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X24_Y-99..Fibroblast X27_Y-99..Fibroblast X24_Y-100..Fibroblast #> PDK4                0.5188800                    0             0.4658342 #> TNFRSF17            0.0000000                    0             0.0000000 #> ICAM3               0.0000000                    0             0.0000000 #> FAP                 0.9698192                    0             1.1533678 #> GZMB                0.0000000                    0             0.0000000 #> TSC2                0.0000000                    0             0.0000000 #>          X27_Y-100..Fibroblast X28_Y-100..Fibroblast X25_Y-100..Fibroblast #> PDK4                 0.3642174             0.4508308               1.38022 #> TNFRSF17             0.0000000             0.0000000               0.00000 #> ICAM3                0.0000000             0.0000000               0.00000 #> FAP                  0.3799260             0.0000000               0.00000 #> GZMB                 0.0000000             0.0000000               0.00000 #> TSC2                 0.0000000             0.0000000               0.00000 #>          X30_Y-101..Fibroblast X29_Y-101..Fibroblast X27_Y-101..Fibroblast #> PDK4                         0              1.935062             0.3613623 #> TNFRSF17                     0              0.000000             0.0000000 #> ICAM3                        0              0.000000             0.0000000 #> FAP                          0              2.322641             0.6005827 #> GZMB                         0              0.000000             0.0000000 #> TSC2                         0              0.000000             0.0000000 #>          X28_Y-101..Fibroblast X26_Y-101..Fibroblast X25_Y-101..Fibroblast #> PDK4                  0.000000             0.0000000             2.6050261 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   1.055024             0.5726165             0.9916916 #> GZMB                  0.000000             0.0000000             0.0000000 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X24_Y-102..Fibroblast X25_Y-102..Fibroblast X27_Y-102..Fibroblast #> PDK4                 1.0414329              1.047422             1.2421699 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.4136545              2.058732             0.4051736 #> GZMB                 0.0000000              0.000000             0.3838474 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X29_Y-102..Fibroblast X26_Y-102..Fibroblast X27_Y-103..Fibroblast #> PDK4                 0.6419852             0.8937872             0.3375831 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  1.8978858             0.3395378             1.2200301 #> GZMB                 0.0000000             0.4798093             0.4241228 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X25_Y-103..Fibroblast X26_Y-103..Fibroblast X24_Y-103..Fibroblast #> PDK4                 1.5160051             0.4210136             0.8516600 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.9257624             1.0546030             0.7200374 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X28_Y-103..Fibroblast X24_Y-104..Fibroblast X28_Y-104..Fibroblast #> PDK4                 0.0000000             0.6040406             0.6685549 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             1.1703600             0.6269447 #> GZMB                 0.8482456             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X25_Y-104..Fibroblast X26_Y-100..Fibroblast X28_Y-102..Fibroblast #> PDK4                 0.7248487                     0             0.0000000 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.7248487                     0             0.6574802 #> GZMB                 0.0000000                     0             0.0000000 #> TSC2                 0.0000000                     0             0.0000000 #>          X73_Y-104..Fibroblast X73_Y-105..Fibroblast X76_Y-105..Fibroblast #> PDK4                 0.0000000             0.4771045                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.4311771             0.0000000                     0 #> GZMB                 0.0000000             0.0000000                     0 #> TSC2                 0.0000000             0.0000000                     0 #>          X75_Y-105..Fibroblast X79_Y-105..Fibroblast X78_Y-105..Fibroblast #> PDK4                   0.00000              1.381168             0.6905840 #> TNFRSF17               0.00000              0.000000             0.0000000 #> ICAM3                  0.00000              0.000000             0.0000000 #> FAP                    2.98102              0.000000             0.0000000 #> GZMB                   0.00000              0.000000             0.0000000 #> TSC2                   0.00000              0.000000             0.8881096 #>          X75_Y-106..Fibroblast X72_Y-106..Fibroblast X73_Y-106..Fibroblast #> PDK4                 0.3505847             0.0000000             0.3248682 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.6318967             0.6812369             0.2439164 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.4022998             0.0000000 #>          X78_Y-106..Fibroblast X74_Y-106..Fibroblast X75_Y-107..Fibroblast #> PDK4                 0.9207787             0.6619583             0.4241228 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.0000000             1.4184817 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 1.1841461             0.0000000             0.0000000 #>          X74_Y-107..Fibroblast X73_Y-107..Fibroblast X74_Y-105..Fibroblast #> PDK4                 1.2735259             0.6002198                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.5643347             0.2695702                     0 #> GZMB                 0.0000000             0.0000000                     0 #> TSC2                 0.0000000             0.0000000                     0 #>          X72_Y-105..Fibroblast X76_Y-106..Fibroblast X63_Y-98..Fibroblast #> PDK4                 0.0000000                     0            0.4897877 #> TNFRSF17             0.0000000                     0            0.0000000 #> ICAM3                0.0000000                     0            0.0000000 #> FAP                  0.3729684                     0            0.9561386 #> GZMB                 0.0000000                     0            0.2046723 #> TSC2                 0.0000000                     0            0.0000000 #>          X61_Y-98..Fibroblast X64_Y-98..Fibroblast X66_Y-98..Fibroblast #> PDK4                        0            0.0000000                    0 #> TNFRSF17                    0            0.0000000                    0 #> ICAM3                       0            0.0000000                    0 #> FAP                         0            0.4131166                    0 #> GZMB                        0            0.0000000                    0 #> TSC2                        0            0.0000000                    0 #>          X62_Y-99..Fibroblast X63_Y-99..Fibroblast X64_Y-99..Fibroblast #> PDK4                0.9757137            0.0000000            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            0.5706292            0.2754111 #> GZMB                0.0000000            0.5141955            0.2754111 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X65_Y-99..Fibroblast X66_Y-99..Fibroblast X61_Y-99..Fibroblast #> PDK4                0.0000000            0.0000000                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.3053455            0.4208048                    0 #> GZMB                0.0000000            0.0000000                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X67_Y-99..Fibroblast X63_Y-100..Fibroblast X67_Y-100..Fibroblast #> PDK4                        0             1.1176276             0.0000000 #> TNFRSF17                    0             0.0000000             0.0000000 #> ICAM3                       0             0.0000000             0.0000000 #> FAP                         0             0.0000000             0.3825498 #> GZMB                        0             0.6125405             0.0000000 #> TSC2                        0             0.0000000             0.0000000 #>          X65_Y-100..Fibroblast X66_Y-100..Fibroblast X64_Y-100..Fibroblast #> PDK4                 0.0000000              0.000000             0.8782461 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.5322132              1.225304             0.3667859 #> GZMB                 0.0000000              0.000000             0.0000000 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X62_Y-100..Fibroblast X61_Y-101..Fibroblast X63_Y-101..Fibroblast #> PDK4                  1.257597             0.0000000                     0 #> TNFRSF17              0.000000             0.0000000                     0 #> ICAM3                 0.000000             0.0000000                     0 #> FAP                   0.000000             0.5930057                     0 #> GZMB                  1.288301             0.6711014                     0 #> TSC2                  0.000000             0.0000000                     0 #>          X65_Y-101..Fibroblast X66_Y-101..Fibroblast X62_Y-101..Fibroblast #> PDK4                 0.3484487             0.0000000             0.6762608 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.4774308             0.7055575             0.0000000 #> GZMB                 0.6006660             0.7638729             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X64_Y-101..Fibroblast X64_Y-102..Fibroblast X66_Y-102..Fibroblast #> PDK4                 0.4529834             0.0000000             0.3617165 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.6061259             0.0000000             0.3101507 #> GZMB                 0.3260504             0.5515678             0.4234501 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X63_Y-102..Fibroblast X67_Y-102..Fibroblast X62_Y-102..Fibroblast #> PDK4                 0.0000000             0.0000000             0.6395237 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  1.3726882             0.6203013             0.7078717 #> GZMB                 0.7721949             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X65_Y-102..Fibroblast X65_Y-103..Fibroblast X61_Y-103..Fibroblast #> PDK4                 0.0000000             0.0000000             0.8875293 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.4598682             0.8524111             0.0000000 #> GZMB                 0.9758506             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X60_Y-103..Fibroblast X62_Y-103..Fibroblast X63_Y-103..Fibroblast #> PDK4                 1.0362269             0.0000000             0.7760517 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.4424198             0.6880334 #> GZMB                 0.9333217             0.5188800             0.4151040 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X64_Y-103..Fibroblast X66_Y-104..Fibroblast X65_Y-98..Fibroblast #> PDK4                 0.4950648             0.0000000                    0 #> TNFRSF17             0.0000000             0.0000000                    0 #> ICAM3                0.0000000             0.0000000                    0 #> FAP                  0.7274452             0.0000000                    0 #> GZMB                 0.0000000             0.4759796                    0 #> TSC2                 0.0000000             0.0000000                    0 #>          X60_Y-99..Fibroblast X61_Y-100..Fibroblast X67_Y-101..Fibroblast #> PDK4                0.4019761                     0             0.3213693 #> TNFRSF17            0.0000000                     0             0.0000000 #> ICAM3               0.0000000                     0             0.0000000 #> FAP                 0.8454358                     0             0.9199062 #> GZMB                0.0000000                     0             0.0000000 #> TSC2                0.0000000                     0             0.0000000 #>          X60_Y-101..Fibroblast X61_Y-102..Fibroblast X66_Y-103..Fibroblast #> PDK4                 0.5409021              1.475532               0.00000 #> TNFRSF17             0.0000000              0.000000               0.00000 #> ICAM3                0.0000000              0.000000               0.00000 #> FAP                  1.1648901              1.456113               0.76717 #> GZMB                 0.9395419              0.000000               0.00000 #> TSC2                 0.0000000              0.000000               0.00000 #>          X60_Y-104..Fibroblast X22_Y-105..Fibroblast X22_Y-106..Fibroblast #> PDK4                 0.0000000                     0                     0 #> TNFRSF17             0.0000000                     0                     0 #> ICAM3                0.0000000                     0                     0 #> FAP                  0.8773159                     0                     0 #> GZMB                 0.0000000                     0                     0 #> TSC2                 0.0000000                     0                     0 #>          X23_Y-106..Fibroblast X23_Y-107..Fibroblast X23_Y-105..Fibroblast #> PDK4                 0.8941229             0.8277628                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.4303865             0.0000000                     0 #> GZMB                 0.0000000             0.0000000                     0 #> TSC2                 0.0000000             0.0000000                     0 #>          X22_Y-107..Fibroblast X70_Y-85..Fibroblast X66_Y-85..Fibroblast #> PDK4                  0.000000                    0             1.085847 #> TNFRSF17              0.000000                    0             0.000000 #> ICAM3                 0.000000                    0             0.000000 #> FAP                   1.874679                    0             1.060692 #> GZMB                  0.000000                    0             0.000000 #> TSC2                  0.000000                    0             0.000000 #>          X71_Y-86..Fibroblast X67_Y-86..Fibroblast X70_Y-86..Fibroblast #> PDK4                0.0000000                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 0.5057421                    0                    0 #> GZMB                0.0000000                    0                    0 #> TSC2                0.0000000                    0                    0 #>          X68_Y-86..Fibroblast X69_Y-86..Fibroblast X69_Y-87..Fibroblast #> PDK4                        0             1.233979             1.233979 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             0.000000             0.000000 #> GZMB                        0             0.000000             0.000000 #> TSC2                        0             0.000000             0.000000 #>          X70_Y-87..Fibroblast X71_Y-87..Fibroblast X67_Y-87..Fibroblast #> PDK4                0.0000000            0.0000000             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.3904158            0.6378785             0.000000 #> GZMB                0.2360667            0.0000000             1.504975 #> TSC2                0.0000000            0.0000000             0.000000 #>          X69_Y-88..Fibroblast X70_Y-88..Fibroblast X68_Y-88..Fibroblast #> PDK4                0.4776059            0.0000000            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.4338119            0.9381192            0.5784158 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X71_Y-88..Fibroblast X67_Y-88..Fibroblast X71_Y-89..Fibroblast #> PDK4                0.0000000            0.0000000            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.9307907            0.8473933            0.7715896 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X70_Y-89..Fibroblast X72_Y-89..Fibroblast X69_Y-89..Fibroblast #> PDK4                 1.213860            0.1774576             1.586287 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  1.108823            0.6995628             0.000000 #> GZMB                 0.000000            0.0000000             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X68_Y-89..Fibroblast X67_Y-89..Fibroblast X70_Y-90..Fibroblast #> PDK4                 0.000000            0.4661310            0.0000000 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.314511            0.9437957            1.6473947 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.4009437 #>          X68_Y-90..Fibroblast X71_Y-90..Fibroblast X69_Y-90..Fibroblast #> PDK4                 0.000000            0.0000000             0.000000 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  1.250171            0.6983464             1.170967 #> GZMB                 0.000000            0.0000000             0.000000 #> TSC2                 0.000000            0.2756488             0.000000 #>          X67_Y-90..Fibroblast X67_Y-91..Fibroblast X68_Y-91..Fibroblast #> PDK4                0.0000000                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 0.8230942                    0                    0 #> GZMB                0.0000000                    0                    0 #> TSC2                0.0000000                    0                    0 #>          X29_Y-104..Fibroblast X27_Y-104..Fibroblast X30_Y-104..Fibroblast #> PDK4                 0.4610518             0.4126741             1.7625111 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.5733768             0.0000000             0.8399009 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X24_Y-105..Fibroblast X27_Y-105..Fibroblast X25_Y-105..Fibroblast #> PDK4                 0.5418188             0.5272058             0.4311194 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.6497364             0.6588621 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X26_Y-105..Fibroblast X28_Y-105..Fibroblast X25_Y-106..Fibroblast #> PDK4                 0.4790215                     0             0.6838867 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.3726951                     0             0.0000000 #> GZMB                 0.0000000                     0             0.0000000 #> TSC2                 0.0000000                     0             0.6037167 #>          X28_Y-106..Fibroblast X26_Y-106..Fibroblast X27_Y-106..Fibroblast #> PDK4                 0.3550411             0.0000000             0.5272058 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.5013166             0.0000000             0.6497364 #> GZMB                 0.0000000             0.6248929             0.0000000 #> TSC2                 0.0000000             0.5749334             0.0000000 #>          X24_Y-106..Fibroblast X29_Y-106..Fibroblast X25_Y-107..Fibroblast #> PDK4                         0                     0             0.6809493 #> TNFRSF17                     0                     0             0.0000000 #> ICAM3                        0                     0             0.0000000 #> FAP                          0                     0             0.2729593 #> GZMB                         0                     0             0.0000000 #> TSC2                         0                     0             0.7244601 #>          X29_Y-107..Fibroblast X24_Y-107..Fibroblast X27_Y-107..Fibroblast #> PDK4                  0.000000              1.031685                     0 #> TNFRSF17              0.000000              0.000000                     0 #> ICAM3                 0.000000              0.000000                     0 #> FAP                   1.133571              0.000000                     0 #> GZMB                  0.000000              0.000000                     0 #> TSC2                  0.000000              0.000000                     0 #>          X28_Y-107..Fibroblast X26_Y-107..Fibroblast X29_Y-105..Fibroblast #> PDK4                 0.0000000             0.4549322              0.000000 #> TNFRSF17             0.0000000             0.0000000              0.000000 #> ICAM3                0.0000000             0.0000000              0.000000 #> FAP                  0.7616073             0.4549322              1.290042 #> GZMB                 0.0000000             0.6248929              0.000000 #> TSC2                 0.0000000             0.0000000              0.000000 #>          X71_Y-98..Fibroblast X68_Y-98..Fibroblast X70_Y-98..Fibroblast #> PDK4                 1.082487            0.0000000                    0 #> TNFRSF17             0.000000            0.0000000                    0 #> ICAM3                0.000000            0.0000000                    0 #> FAP                  0.000000            0.6807041                    0 #> GZMB                 0.000000            0.0000000                    0 #> TSC2                 0.000000            0.0000000                    0 #>          X72_Y-98..Fibroblast X71_Y-99..Fibroblast X68_Y-99..Fibroblast #> PDK4                0.0000000             0.947690             0.000000 #> TNFRSF17            0.0000000             0.000000             0.000000 #> ICAM3               0.0000000             0.000000             0.000000 #> FAP                 0.5379577             1.000756             1.079688 #> GZMB                0.0000000             0.000000             0.000000 #> TSC2                0.0000000             0.000000             0.000000 #>          X70_Y-99..Fibroblast X69_Y-99..Fibroblast X69_Y-100..Fibroblast #> PDK4                        0            0.0000000             0.0000000 #> TNFRSF17                    0            0.0000000             0.0000000 #> ICAM3                       0            0.0000000             0.0000000 #> FAP                         0            0.4619123             0.4384289 #> GZMB                        0            0.0000000             0.0000000 #> TSC2                        0            0.0000000             0.0000000 #>          X71_Y-100..Fibroblast X72_Y-101..Fibroblast X68_Y-101..Fibroblast #> PDK4                         0             0.0000000             0.0000000 #> TNFRSF17                     0             0.0000000             0.0000000 #> ICAM3                        0             0.0000000             0.0000000 #> FAP                          0             0.3461642             0.3961006 #> GZMB                         0             0.0000000             0.0000000 #> TSC2                         0             0.0000000             0.0000000 #>          X69_Y-101..Fibroblast X70_Y-101..Fibroblast X71_Y-101..Fibroblast #> PDK4                 0.3752483              0.000000             0.3263064 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  1.2067638              0.000000             0.6100903 #> GZMB                 0.2124953              1.053623             0.3709000 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X69_Y-102..Fibroblast X71_Y-102..Fibroblast X70_Y-102..Fibroblast #> PDK4                 0.2501655             0.0000000              0.000000 #> TNFRSF17             0.0000000             0.0000000              0.000000 #> ICAM3                0.0000000             0.0000000              0.000000 #> FAP                  1.1894307             0.6483281              0.467661 #> GZMB                 0.3520267             0.0000000              0.000000 #> TSC2                 0.0000000             0.0000000              0.000000 #>          X68_Y-102..Fibroblast X72_Y-102..Fibroblast X71_Y-103..Fibroblast #> PDK4                 0.0000000             0.2690149             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.8531293             0.7217288             0.9815842 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.2467957             0.0000000 #>          X69_Y-103..Fibroblast X68_Y-103..Fibroblast X72_Y-103..Fibroblast #> PDK4                 0.2300295             0.3578237             0.3104018 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.8086465             0.4774214             0.6055361 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.2847643 #>          X67_Y-103..Fibroblast X68_Y-104..Fibroblast X70_Y-100..Fibroblast #> PDK4                 0.0000000             0.4290067                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.6138275             1.0694706                     0 #> GZMB                 0.0000000             0.0000000                     0 #> TSC2                 0.0000000             0.0000000                     0 #>          X68_Y-100..Fibroblast X70_Y-103..Fibroblast X71_Y-104..Fibroblast #> PDK4                         0             0.0000000              0.000000 #> TNFRSF17                     0             0.0000000              0.000000 #> ICAM3                        0             0.0000000              0.000000 #> FAP                          0             0.6397457              1.014232 #> GZMB                         0             0.0000000              0.000000 #> TSC2                         0             0.0000000              0.000000 #>          X72_Y-104..Fibroblast X67_Y-104..Fibroblast X70_Y-104..Fibroblast #> PDK4                  0.000000             0.6565023             0.0000000 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   1.457654             0.0000000             0.3522851 #> GZMB                  0.000000             0.5439766             0.0000000 #> TSC2                  0.000000             0.5333267             0.0000000 #>          X69_Y-104..Fibroblast X68_Y-105..Fibroblast X70_Y-105..Fibroblast #> PDK4                 0.0000000             1.1064281             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.4874271             0.4251274             0.2167908 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X69_Y-105..Fibroblast X71_Y-105..Fibroblast X67_Y-105..Fibroblast #> PDK4                 0.5170491                     0             0.4595516 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.0000000                     0             0.6499225 #> GZMB                 0.2625233                     0             0.3757496 #> TSC2                 0.0000000                     0             0.0000000 #>          X70_Y-106..Fibroblast X69_Y-106..Fibroblast X71_Y-106..Fibroblast #> PDK4                 0.2795214             0.9442789             0.5744395 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.6616763             0.9442789             0.0000000 #> GZMB                 0.0000000             0.5250466             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X67_Y-106..Fibroblast X68_Y-106..Fibroblast X66_Y-106..Fibroblast #> PDK4                 0.8808008                     0             0.5563994 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  1.2654134                     0             1.1313216 #> GZMB                 0.0000000                     0             0.0000000 #> TSC2                 0.0000000                     0             0.0000000 #>          X67_Y-107..Fibroblast X69_Y-107..Fibroblast X71_Y-107..Fibroblast #> PDK4                 0.9039017             1.1259124             1.1944822 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  1.4051001             0.7344391             0.0000000 #> GZMB                 0.0000000             0.0000000             0.3204398 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X68_Y-107..Fibroblast X70_Y-107..Fibroblast X72_Y-107..Fibroblast #> PDK4                  0.000000             0.0000000             0.3204398 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   1.661401             0.5095399             0.3414830 #> GZMB                  1.661401             0.0000000             0.3204398 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X66_Y-105..Fibroblast X55_Y-103..Fibroblast X58_Y-104..Fibroblast #> PDK4                 0.0000000              0.000000                     0 #> TNFRSF17             0.0000000              0.000000                     0 #> ICAM3                0.0000000              0.000000                     0 #> FAP                  0.8787854              1.609473                     0 #> GZMB                 0.3131246              0.000000                     0 #> TSC2                 0.0000000              0.000000                     0 #>          X57_Y-104..Fibroblast X60_Y-105..Fibroblast X58_Y-105..Fibroblast #> PDK4                  0.000000             0.0000000             0.7313531 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   1.258688             0.7296204             0.0000000 #> GZMB                  0.000000             0.0000000             0.0000000 #> TSC2                  0.000000             0.8529205             0.0000000 #>          X59_Y-105..Fibroblast X55_Y-106..Fibroblast X58_Y-106..Fibroblast #> PDK4                  0.000000             0.0000000             1.9561606 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   1.300952             0.7359204             0.3644431 #> GZMB                  0.000000             0.0000000             0.0000000 #> TSC2                  1.302541             0.0000000             0.0000000 #>          X57_Y-106..Fibroblast X57_Y-107..Fibroblast X55_Y-107..Fibroblast #> PDK4                 0.6790135             1.4590905             0.6753700 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.4791795             0.6708513             0.4236967 #> GZMB                 0.0000000             0.0000000             0.3425466 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X59_Y-107..Fibroblast X56_Y-107..Fibroblast X58_Y-107..Fibroblast #> PDK4                  1.247696             0.9481295              1.247696 #> TNFRSF17              0.000000             0.0000000              0.000000 #> ICAM3                 0.000000             0.0000000              0.000000 #> FAP                   0.000000             0.0000000              0.000000 #> GZMB                  0.000000             0.3914818              0.000000 #> TSC2                  0.000000             0.0000000              0.000000 #>          X54_Y-107..Fibroblast X54_Y-103..Fibroblast X57_Y-103..Fibroblast #> PDK4                 1.3389322             0.2860741              0.000000 #> TNFRSF17             0.0000000             0.0000000              0.000000 #> ICAM3                0.0000000             0.0000000              0.000000 #> FAP                  0.8473933             1.0981142              1.055542 #> GZMB                 0.0000000             0.0000000              0.000000 #> TSC2                 0.0000000             0.0000000              0.000000 #>          X55_Y-104..Fibroblast X59_Y-104..Fibroblast X57_Y-105..Fibroblast #> PDK4                  0.000000                     0                     0 #> TNFRSF17              0.000000                     0                     0 #> ICAM3                 0.000000                     0                     0 #> FAP                   1.251645                     0                     0 #> GZMB                  0.000000                     0                     0 #> TSC2                  0.000000                     0                     0 #>          X61_Y-105..Fibroblast X56_Y-105..Fibroblast X54_Y-105..Fibroblast #> PDK4                  0.000000              0.000000             0.3266462 #> TNFRSF17              0.000000              0.000000             0.0000000 #> ICAM3                 0.000000              0.000000             0.0000000 #> FAP                   1.014841              1.785589             0.8799770 #> GZMB                  0.000000              0.000000             0.0000000 #> TSC2                  0.000000              0.000000             0.0000000 #>          X56_Y-106..Fibroblast X59_Y-106..Fibroblast X54_Y-106..Fibroblast #> PDK4                 0.5566477             0.9287627             0.4498868 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.5415371             1.0469555             0.9605672 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X61_Y-104..Fibroblast X63_Y-104..Fibroblast X64_Y-104..Fibroblast #> PDK4                         0             0.6609866             0.6767955 #> TNFRSF17                     0             0.0000000             0.0000000 #> ICAM3                        0             0.0000000             0.0000000 #> FAP                          0             0.6497061             1.3436254 #> GZMB                         0             0.0000000             0.0000000 #> TSC2                         0             0.0000000             0.0000000 #>          X62_Y-104..Fibroblast X65_Y-105..Fibroblast X64_Y-105..Fibroblast #> PDK4                  1.132458                     0              2.129786 #> TNFRSF17              0.000000                     0              0.000000 #> ICAM3                 0.000000                     0              0.000000 #> FAP                   2.348338                     0              1.624079 #> GZMB                  0.000000                     0              0.000000 #> TSC2                  0.000000                     0              0.000000 #>          X62_Y-105..Fibroblast X64_Y-106..Fibroblast X63_Y-106..Fibroblast #> PDK4                 0.7865817             0.8982001                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.7173277             0.0000000                     0 #> GZMB                 0.0000000             0.0000000                     0 #> TSC2                 0.0000000             0.0000000                     0 #>          X65_Y-106..Fibroblast X63_Y-107..Fibroblast X64_Y-107..Fibroblast #> PDK4                 0.6641021                     0             0.4427347 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.6641021                     0             0.4427347 #> GZMB                 0.0000000                     0             0.0000000 #> TSC2                 0.0000000                     0             0.0000000 #>          X61_Y-107..Fibroblast X65_Y-107..Fibroblast X66_Y-107..Fibroblast #> PDK4                  1.718205             0.5312817             0.4769138 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             0.5312817             0.5327587 #> GZMB                  0.000000             0.0000000             0.0000000 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X65_Y-104..Fibroblast X63_Y-105..Fibroblast X61_Y-106..Fibroblast #> PDK4                  0.000000             0.8377341              1.590443 #> TNFRSF17              0.000000             0.0000000              0.000000 #> ICAM3                 0.000000             0.0000000              0.000000 #> FAP                   1.436638             0.7490629              0.000000 #> GZMB                  0.000000             0.0000000              0.000000 #> TSC2                  0.000000             0.0000000              1.264223 #>          X62_Y-106..Fibroblast X53_Y-103..Fibroblast X52_Y-104..Fibroblast #> PDK4                  1.593129                     0             0.2794582 #> TNFRSF17              0.000000                     0             0.0000000 #> ICAM3                 0.000000                     0             0.0000000 #> FAP                   0.000000                     0             0.8099156 #> GZMB                  0.000000                     0             0.1900079 #> TSC2                  0.000000                     0             0.0000000 #>          X50_Y-104..Fibroblast X53_Y-104..Fibroblast X51_Y-104..Fibroblast #> PDK4                 0.3821549             0.0000000             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.6334233             0.3182058             0.8658485 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X49_Y-104..Fibroblast X54_Y-104..Fibroblast X53_Y-105..Fibroblast #> PDK4                  0.000000             0.3266462             0.5531283 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   1.464816             0.8551049             0.2386544 #> GZMB                  0.000000             0.0000000             0.0000000 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X51_Y-105..Fibroblast X48_Y-105..Fibroblast X49_Y-105..Fibroblast #> PDK4                 0.3417678             0.9575203             0.3641700 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.3936740             0.3565519             0.4357857 #> GZMB                 0.0000000             0.3663438             0.4477535 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X52_Y-105..Fibroblast X50_Y-105..Fibroblast X51_Y-106..Fibroblast #> PDK4                 0.9839726             0.8866256             0.4272098 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.8409624             0.0000000             0.4920925 #> GZMB                 0.3325138             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X49_Y-106..Fibroblast X53_Y-106..Fibroblast X48_Y-106..Fibroblast #> PDK4                         0              0.000000             0.3529666 #> TNFRSF17                     0              0.000000             0.0000000 #> ICAM3                        0              0.000000             0.0000000 #> FAP                          0              1.573342             1.5057273 #> GZMB                         0              0.000000             0.4893729 #> TSC2                         0              0.000000             0.0000000 #>          X52_Y-106..Fibroblast X52_Y-107..Fibroblast X49_Y-107..Fibroblast #> PDK4                 0.0000000             0.0000000              0.000000 #> TNFRSF17             0.0000000             0.0000000              0.000000 #> ICAM3                0.0000000             0.0000000              0.000000 #> FAP                  0.8236342             0.7602777              2.118001 #> GZMB                 0.0000000             0.3095669              0.000000 #> TSC2                 0.0000000             0.0000000              0.000000 #>          X53_Y-107..Fibroblast X51_Y-107..Fibroblast X52_Y-103..Fibroblast #> PDK4                 0.0000000             0.7140233             0.5828124 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  1.4000349             1.0101741             0.8594771 #> GZMB                 0.5030463             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X55_Y-105..Fibroblast X48_Y-107..Fibroblast X50_Y-107..Fibroblast #> PDK4                         0             0.4412083              1.428047 #> TNFRSF17                     0             0.0000000              0.000000 #> ICAM3                        0             0.0000000              0.000000 #> FAP                          0             1.9157724              1.975818 #> GZMB                         0             0.6117162              0.000000 #> TSC2                         0             0.0000000              0.000000 #>          X36_Y-103..Fibroblast X33_Y-104..Fibroblast X31_Y-104..Fibroblast #> PDK4                         0                     0              0.000000 #> TNFRSF17                     0                     0              0.000000 #> ICAM3                        0                     0              0.000000 #> FAP                          0                     0              1.790846 #> GZMB                         0                     0              0.000000 #> TSC2                         0                     0              0.000000 #>          X33_Y-105..Fibroblast X31_Y-105..Fibroblast X35_Y-105..Fibroblast #> PDK4                  1.014207             0.5568369              0.000000 #> TNFRSF17              0.000000             0.0000000              0.000000 #> ICAM3                 0.000000             0.0000000              0.000000 #> FAP                   0.000000             0.6434957              1.849044 #> GZMB                  0.000000             0.0000000              1.849044 #> TSC2                  0.000000             0.0000000              0.000000 #>          X30_Y-105..Fibroblast X32_Y-105..Fibroblast X34_Y-105..Fibroblast #> PDK4                  1.497186              1.170192              0.434660 #> TNFRSF17              0.000000              0.000000              0.000000 #> ICAM3                 0.000000              0.000000              0.000000 #> FAP                   0.000000              0.000000              1.018103 #> GZMB                  0.000000              0.000000              0.000000 #> TSC2                  0.000000              0.000000              0.000000 #>          X35_Y-106..Fibroblast X34_Y-106..Fibroblast X33_Y-106..Fibroblast #> PDK4                 0.6721578              0.924217             0.6085239 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.6331628              1.379874             0.0000000 #> GZMB                 0.0000000              0.000000             0.0000000 #> TSC2                 0.4241744              0.000000             0.0000000 #>          X31_Y-106..Fibroblast X32_Y-106..Fibroblast X30_Y-106..Fibroblast #> PDK4                 0.6763057             1.1156949                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.8527935             0.3851815                     0 #> GZMB                 0.0000000             0.3234717                     0 #> TSC2                 0.0000000             0.0000000                     0 #>          X32_Y-107..Fibroblast X31_Y-107..Fibroblast X33_Y-107..Fibroblast #> PDK4                 0.0000000             0.4305392             0.4413050 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.7749157             0.0000000             0.5508222 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X34_Y-107..Fibroblast X30_Y-107..Fibroblast X42_Y-103..Fibroblast #> PDK4                 0.0000000                     0             0.2370491 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.6790335                     0             1.2560423 #> GZMB                 0.0000000                     0             0.0000000 #> TSC2                 0.0000000                     0             0.1985613 #>          X42_Y-104..Fibroblast X45_Y-104..Fibroblast X46_Y-104..Fibroblast #> PDK4                 0.6912709                     0              1.950381 #> TNFRSF17             0.0000000                     0              0.000000 #> ICAM3                0.0000000                     0              0.000000 #> FAP                  0.7746102                     0              2.569763 #> GZMB                 0.0000000                     0              0.000000 #> TSC2                 0.0000000                     0              0.000000 #>          X42_Y-105..Fibroblast X47_Y-105..Fibroblast X47_Y-106..Fibroblast #> PDK4                 1.4404206             0.6465605             0.3689192 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.4296007             0.0000000             0.5596204 #> GZMB                 0.5974709             0.0000000             0.0000000 #> TSC2                 0.4296007             0.0000000             0.0000000 #>          X42_Y-106..Fibroblast X45_Y-106..Fibroblast X46_Y-106..Fibroblast #> PDK4                 0.6703188             0.0000000             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             1.8758498             1.7271693 #> GZMB                 0.0000000             0.5663194             0.3089015 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X43_Y-106..Fibroblast X47_Y-107..Fibroblast X46_Y-107..Fibroblast #> PDK4                         0             0.8632259              0.000000 #> TNFRSF17                     0             0.0000000              0.000000 #> ICAM3                        0             0.0000000              0.000000 #> FAP                          0             0.9941710              1.662983 #> GZMB                         0             0.0000000              0.000000 #> TSC2                         0             0.0000000              0.000000 #>          X42_Y-107..Fibroblast X44_Y-107..Fibroblast X45_Y-107..Fibroblast #> PDK4                 0.7691868             0.5872100             0.5666809 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.6110001             0.0000000             2.3147356 #> GZMB                 0.0000000             0.5266862             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X43_Y-107..Fibroblast X58_Y-98..Fibroblast X56_Y-98..Fibroblast #> PDK4                 0.7046519            0.0000000            0.5984861 #> TNFRSF17             0.0000000            0.0000000            0.0000000 #> ICAM3                0.0000000            0.0000000            0.0000000 #> FAP                  0.5939217            0.8879225            1.9539279 #> GZMB                 0.6320235            0.0000000            0.3942069 #> TSC2                 0.0000000            0.0000000            0.0000000 #>          X58_Y-99..Fibroblast X59_Y-99..Fibroblast X54_Y-99..Fibroblast #> PDK4                        0            0.0000000            0.3887992 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            1.1806558            0.9301350 #> GZMB                        0            0.0000000            0.0000000 #> TSC2                        0            0.3226325            0.0000000 #>          X56_Y-99..Fibroblast X55_Y-99..Fibroblast X60_Y-100..Fibroblast #> PDK4                0.0000000            0.1814396             0.4613844 #> TNFRSF17            0.0000000            0.0000000             0.0000000 #> ICAM3               0.0000000            0.0000000             0.0000000 #> FAP                 0.6256507            0.6114199             0.0000000 #> GZMB                0.0000000            0.2483568             0.0000000 #> TSC2                0.0000000            0.0000000             0.0000000 #>          X56_Y-100..Fibroblast X59_Y-100..Fibroblast X54_Y-100..Fibroblast #> PDK4                 1.0115501             0.0000000             0.4005498 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.8792241             0.6887931             0.0000000 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.3351743 #>          X55_Y-101..Fibroblast X56_Y-101..Fibroblast X54_Y-101..Fibroblast #> PDK4                 0.3890193             0.9487431                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.6372311             0.3330229                     0 #> GZMB                 0.0000000             0.0000000                     0 #> TSC2                 0.5116966             0.0000000                     0 #>          X57_Y-101..Fibroblast X59_Y-101..Fibroblast X58_Y-101..Fibroblast #> PDK4                 0.0000000              1.285477             0.7712864 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.8229633              0.000000             0.0000000 #> GZMB                 0.0000000              0.000000             0.0000000 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X56_Y-102..Fibroblast X55_Y-102..Fibroblast X59_Y-102..Fibroblast #> PDK4                 0.0000000             0.3501174               0.00000 #> TNFRSF17             0.0000000             0.0000000               0.00000 #> ICAM3                0.0000000             0.0000000               0.00000 #> FAP                  0.3746507             0.0000000               1.73859 #> GZMB                 0.0000000             0.0000000               0.00000 #> TSC2                 0.0000000             0.4605269               0.00000 #>          X60_Y-102..Fibroblast X58_Y-102..Fibroblast X54_Y-102..Fibroblast #> PDK4                 0.6908180              0.000000              0.000000 #> TNFRSF17             0.0000000              0.000000              0.000000 #> ICAM3                0.0000000              0.000000              0.000000 #> FAP                  1.1590600              1.337879              1.105034 #> GZMB                 0.6222145              0.000000              1.105034 #> TSC2                 0.0000000              0.000000              0.000000 #>          X56_Y-103..Fibroblast X59_Y-103..Fibroblast X58_Y-103..Fibroblast #> PDK4                  0.000000             0.0000000             0.7607077 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   1.784523             0.7432998             0.8919597 #> GZMB                  0.000000             0.0000000             0.0000000 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X56_Y-104..Fibroblast X54_Y-98..Fibroblast X57_Y-99..Fibroblast #> PDK4                  0.000000            0.5443189                    0 #> TNFRSF17              0.000000            0.0000000                    0 #> ICAM3                 0.000000            0.0000000                    0 #> FAP                   2.638293            1.8809826                    0 #> GZMB                  0.000000            0.0000000                    0 #> TSC2                  0.000000            0.0000000                    0 #>          X55_Y-100..Fibroblast X58_Y-100..Fibroblast X57_Y-100..Fibroblast #> PDK4                         0              0.000000              0.000000 #> TNFRSF17                     0              0.000000              0.000000 #> ICAM3                        0              0.000000              0.000000 #> FAP                          0              1.888032              0.944016 #> GZMB                         0              0.000000              0.000000 #> TSC2                         0              0.000000              0.000000 #>          X57_Y-102..Fibroblast X39_Y-97..Fibroblast X40_Y-97..Fibroblast #> PDK4                  0.000000            0.5372937              0.00000 #> TNFRSF17              0.000000            0.0000000              0.00000 #> ICAM3                 0.000000            0.0000000              0.00000 #> FAP                   2.006819            0.2607364              1.82414 #> GZMB                  0.000000            0.0000000              0.00000 #> TSC2                  0.000000            0.0000000              0.00000 #>          X38_Y-97..Fibroblast X37_Y-97..Fibroblast X41_Y-97..Fibroblast #> PDK4                1.1456085            0.3097464            0.2411444 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            1.6032776            0.2043813 #> GZMB                0.2207893            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.2043813 #>          X40_Y-98..Fibroblast X41_Y-98..Fibroblast X42_Y-98..Fibroblast #> PDK4                 0.000000            0.3598160            0.6204630 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.345899            0.3852543            0.3845934 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X39_Y-98..Fibroblast X37_Y-98..Fibroblast X38_Y-98..Fibroblast #> PDK4                0.0000000            0.7682732            0.7783198 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.8732760            1.1496469            0.0000000 #> GZMB                0.3108228            0.0000000            0.3412198 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X41_Y-99..Fibroblast X37_Y-99..Fibroblast X39_Y-99..Fibroblast #> PDK4                 0.000000            1.1369921            0.2759209 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.286145            0.2701157            1.3011467 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X40_Y-99..Fibroblast X36_Y-99..Fibroblast X38_Y-99..Fibroblast #> PDK4                0.2232225             1.471354              1.06593 #> TNFRSF17            0.0000000             0.000000              0.00000 #> ICAM3               0.0000000             0.000000              0.00000 #> FAP                 1.3941211             2.407496              0.00000 #> GZMB                0.0000000             0.000000              0.00000 #> TSC2                0.1523141             0.000000              0.00000 #>          X42_Y-99..Fibroblast X40_Y-100..Fibroblast X41_Y-100..Fibroblast #> PDK4                 0.000000             0.1944345             0.0000000 #> TNFRSF17             0.000000             0.0000000             0.0000000 #> ICAM3                0.000000             0.0000000             0.0000000 #> FAP                  1.350857             0.5116129             0.5246889 #> GZMB                 0.000000             0.0000000             0.0000000 #> TSC2                 0.000000             0.0000000             0.0000000 #>          X37_Y-100..Fibroblast X42_Y-100..Fibroblast X39_Y-100..Fibroblast #> PDK4                 0.3650405             0.3926936             1.2719844 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.8937394             1.4816009             0.3997759 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X38_Y-100..Fibroblast X37_Y-101..Fibroblast X38_Y-101..Fibroblast #> PDK4                 0.8854436              1.053763              1.144211 #> TNFRSF17             0.0000000              0.000000              0.000000 #> ICAM3                0.0000000              0.000000              0.000000 #> FAP                  0.4241228              1.567853              1.407179 #> GZMB                 0.0000000              0.000000              0.000000 #> TSC2                 0.0000000              0.000000              0.000000 #>          X40_Y-101..Fibroblast X41_Y-101..Fibroblast X36_Y-101..Fibroblast #> PDK4                  0.000000             0.0000000              3.510576 #> TNFRSF17              0.000000             0.0000000              0.000000 #> ICAM3                 0.000000             0.0000000              0.000000 #> FAP                   1.249052             0.3542951              0.000000 #> GZMB                  0.000000             0.0000000              0.000000 #> TSC2                  0.000000             0.0000000              0.000000 #>          X39_Y-101..Fibroblast X38_Y-102..Fibroblast X40_Y-102..Fibroblast #> PDK4                 0.0000000             0.2674121             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.3351546             0.8423806             1.6251646 #> GZMB                 0.0000000             0.0000000             0.4383548 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X39_Y-102..Fibroblast X42_Y-102..Fibroblast X37_Y-102..Fibroblast #> PDK4                 0.2005591             0.3555737             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  1.4228159             1.7278646             1.3667495 #> GZMB                 0.0000000             0.0000000             0.4866736 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X41_Y-102..Fibroblast X41_Y-103..Fibroblast X39_Y-103..Fibroblast #> PDK4                 0.0000000             0.1990304             0.1856005 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.8920659             0.5981618             0.9403305 #> GZMB                 0.0000000             0.0000000             0.1929639 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X37_Y-103..Fibroblast X38_Y-103..Fibroblast X40_Y-103..Fibroblast #> PDK4                 0.0000000             0.0000000             0.2985456 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  2.5825854             0.2722271             0.8883903 #> GZMB                 0.4866736             0.2806748             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X38_Y-104..Fibroblast X37_Y-104..Fibroblast X41_Y-104..Fibroblast #> PDK4                 0.0000000             0.0000000             0.5760591 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.5609909             0.8309044             0.6146467 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X36_Y-104..Fibroblast X65_Y-85..Fibroblast X64_Y-85..Fibroblast #> PDK4                 0.0000000             1.409273             0.000000 #> TNFRSF17             0.0000000             0.000000             0.000000 #> ICAM3                0.0000000             0.000000             0.000000 #> FAP                  0.5666809             0.000000             4.348158 #> GZMB                 0.0000000             0.000000             0.000000 #> TSC2                 0.0000000             0.000000             0.000000 #>          X61_Y-86..Fibroblast X62_Y-86..Fibroblast X63_Y-86..Fibroblast #> PDK4                0.4168962            0.5084773                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 1.0010197            0.0000000                    0 #> GZMB                0.0000000            0.0000000                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X65_Y-86..Fibroblast X66_Y-86..Fibroblast X64_Y-86..Fibroblast #> PDK4                        0            0.4818724             1.953812 #> TNFRSF17                    0            0.0000000             0.000000 #> ICAM3                       0            0.0000000             0.000000 #> FAP                         0            1.0606918             1.953812 #> GZMB                        0            0.0000000             0.000000 #> TSC2                        0            0.0000000             0.000000 #>          X62_Y-87..Fibroblast X63_Y-87..Fibroblast X64_Y-87..Fibroblast #> PDK4                0.5084773            0.0000000            0.7815246 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.4572018            0.7452447            1.6874913 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X66_Y-87..Fibroblast X61_Y-87..Fibroblast X65_Y-87..Fibroblast #> PDK4                0.0000000                    0             0.000000 #> TNFRSF17            0.0000000                    0             0.000000 #> ICAM3               0.0000000                    0             0.000000 #> FAP                 0.7718556                    0             1.707656 #> GZMB                0.8446409                    0             0.000000 #> TSC2                0.0000000                    0             0.000000 #>          X66_Y-88..Fibroblast X62_Y-88..Fibroblast X64_Y-88..Fibroblast #> PDK4                 0.000000             0.000000            0.0000000 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  2.103003             1.371605            0.9373394 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X65_Y-89..Fibroblast X61_Y-89..Fibroblast X63_Y-89..Fibroblast #> PDK4                        0                    0             0.000000 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             1.371605 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X62_Y-90..Fibroblast X64_Y-90..Fibroblast X66_Y-90..Fibroblast #> PDK4                0.4259954            0.0000000                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 1.7622581            0.6837415                    0 #> GZMB                0.0000000            0.0000000                    0 #> TSC2                0.0000000            0.6837415                    0 #>          X65_Y-90..Fibroblast X61_Y-91..Fibroblast X63_Y-91..Fibroblast #> PDK4                        0             0.000000             0.000000 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             1.692026             1.054471 #> GZMB                        0             0.000000             0.000000 #> TSC2                        0             0.000000             0.000000 #>          X62_Y-89..Fibroblast X63_Y-90..Fibroblast X37_Y-91..Fibroblast #> PDK4                 0.000000                    0             1.010240 #> TNFRSF17             0.000000                    0             0.000000 #> ICAM3                0.000000                    0             0.000000 #> FAP                  2.057408                    0             1.498999 #> GZMB                 0.000000                    0             0.000000 #> TSC2                 0.000000                    0             0.000000 #>          X38_Y-92..Fibroblast X40_Y-92..Fibroblast X37_Y-92..Fibroblast #> PDK4                        0             0.000000             1.319486 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             1.247196             1.654283 #> GZMB                        0             0.000000             0.000000 #> TSC2                        0             0.000000             0.000000 #>          X39_Y-92..Fibroblast X41_Y-92..Fibroblast X38_Y-93..Fibroblast #> PDK4                0.2370491            0.0000000            1.2419922 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.4715580            0.6764174            0.2263061 #> GZMB                0.2227347            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X39_Y-93..Fibroblast X41_Y-93..Fibroblast X37_Y-93..Fibroblast #> PDK4                1.4442007            0.2722967            0.3358098 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.7154197            1.3546102            1.6150238 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X40_Y-93..Fibroblast X40_Y-94..Fibroblast X41_Y-94..Fibroblast #> PDK4                0.8909659            1.0876814             0.285978 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.3911192            0.7261361             1.275212 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X39_Y-94..Fibroblast X37_Y-94..Fibroblast X39_Y-95..Fibroblast #> PDK4                0.8243494            1.9278187            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.8574611            0.7794684            0.7989645 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X38_Y-95..Fibroblast X41_Y-95..Fibroblast X37_Y-95..Fibroblast #> PDK4                0.9025506            0.0000000            0.7036985 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.5780670            0.6475236            0.7364944 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X40_Y-95..Fibroblast X38_Y-96..Fibroblast X36_Y-96..Fibroblast #> PDK4                0.3214652            0.7234609            0.9188316 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.4093807            0.4511217            0.7971641 #> GZMB                0.2363980            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X40_Y-96..Fibroblast X39_Y-96..Fibroblast X41_Y-96..Fibroblast #> PDK4                0.8882202            0.4598756            0.8220362 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.4387050            0.3893389            0.9819880 #> GZMB                0.2000291            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.2043813 #>          X37_Y-96..Fibroblast X38_Y-94..Fibroblast X40_Y-104..Fibroblast #> PDK4                0.1929937             1.089707               0.00000 #> TNFRSF17            0.0000000             0.000000               0.00000 #> ICAM3               0.0000000             0.000000               0.00000 #> FAP                 0.7202887             0.526006               1.51973 #> GZMB                0.2636029             0.000000               0.00000 #> TSC2                0.0000000             0.000000               0.00000 #>          X39_Y-104..Fibroblast X41_Y-105..Fibroblast X39_Y-105..Fibroblast #> PDK4                 0.0000000             0.8731872             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.6544894             0.8473021             0.4363262 #> GZMB                 0.0000000             0.0000000             0.3914733 #> TSC2                 0.0000000             0.2313234             0.0000000 #>          X36_Y-105..Fibroblast X38_Y-105..Fibroblast X37_Y-105..Fibroblast #> PDK4                 0.0000000             0.0000000             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.9245222             0.5881560             0.4521457 #> GZMB                 0.9245222             0.3914733             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X40_Y-105..Fibroblast X37_Y-106..Fibroblast X40_Y-106..Fibroblast #> PDK4                 0.2887552              0.000000              0.000000 #> TNFRSF17             0.0000000              0.000000              0.000000 #> ICAM3                0.0000000              0.000000              0.000000 #> FAP                  0.7281185              1.446933              1.319699 #> GZMB                 0.0000000              0.000000              0.000000 #> TSC2                 0.0000000              0.000000              0.000000 #>          X41_Y-106..Fibroblast X39_Y-106..Fibroblast X38_Y-106..Fibroblast #> PDK4                 0.6445026             0.0000000              0.000000 #> TNFRSF17             0.0000000             0.0000000              0.000000 #> ICAM3                0.0000000             0.0000000              0.000000 #> FAP                  0.4768407             0.7137668              1.942406 #> GZMB                 0.0000000             0.0000000              0.000000 #> TSC2                 0.0000000             0.0000000              0.000000 #>          X36_Y-106..Fibroblast X41_Y-107..Fibroblast X40_Y-107..Fibroblast #> PDK4                  0.000000              1.956842              0.000000 #> TNFRSF17              0.000000              0.000000              0.000000 #> ICAM3                 0.000000              0.000000              0.000000 #> FAP                   2.118284              1.170488              0.887141 #> GZMB                  0.000000              0.000000              0.000000 #> TSC2                  0.000000              0.000000              0.000000 #>          X37_Y-107..Fibroblast X38_Y-107..Fibroblast X39_Y-107..Fibroblast #> PDK4                  0.000000               0.00000              0.000000 #> TNFRSF17              0.000000               0.00000              0.000000 #> ICAM3                 0.000000               0.00000              0.000000 #> FAP                   2.813882               1.30725              0.419282 #> GZMB                  0.000000               0.00000              0.000000 #> TSC2                  0.000000               0.00000              0.000000 #>          X36_Y-107..Fibroblast X49_Y-85..Fibroblast X51_Y-85..Fibroblast #> PDK4                  3.287401             1.964528                    0 #> TNFRSF17              0.000000             0.000000                    0 #> ICAM3                 0.000000             0.000000                    0 #> FAP                   0.000000             0.000000                    0 #> GZMB                  0.000000             0.000000                    0 #> TSC2                  0.000000             0.000000                    0 #>          X51_Y-86..Fibroblast X52_Y-86..Fibroblast X53_Y-86..Fibroblast #> PDK4                 0.000000            0.7636036            0.5303319 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  3.723464            1.6716764            1.7901869 #> GZMB                 0.000000            0.4054935            0.6082402 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X54_Y-86..Fibroblast X52_Y-87..Fibroblast X53_Y-87..Fibroblast #> PDK4                0.0000000            0.4613051                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.5867032            0.4323123                    0 #> GZMB                0.0000000            0.0000000                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X50_Y-87..Fibroblast X51_Y-87..Fibroblast X54_Y-87..Fibroblast #> PDK4                 1.631458            0.0000000            0.0000000 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.000000            0.8646246            0.7466774 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X49_Y-88..Fibroblast X52_Y-88..Fibroblast X54_Y-88..Fibroblast #> PDK4                0.3350555            0.0000000             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.5987128            0.9293772             1.455173 #> GZMB                0.1881227            0.0000000             0.000000 #> TSC2                0.2730116            0.4691772             0.000000 #>          X50_Y-88..Fibroblast X52_Y-89..Fibroblast X49_Y-89..Fibroblast #> PDK4                0.8619906            0.0000000             1.079935 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.3589600            0.5552850             1.101077 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.2232977             0.000000 #>          X51_Y-89..Fibroblast X50_Y-89..Fibroblast X53_Y-89..Fibroblast #> PDK4                0.1969965             0.603127            0.6208967 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.2103396             0.414826            0.8974081 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.1838922             0.000000            0.0000000 #>          X54_Y-89..Fibroblast X53_Y-90..Fibroblast X52_Y-90..Fibroblast #> PDK4                 0.000000            0.8084972            0.3035048 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.422871            0.5386182            1.1155610 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.1713139            0.0000000 #>          X50_Y-90..Fibroblast X55_Y-90..Fibroblast X51_Y-90..Fibroblast #> PDK4                0.6771618             0.000000            0.0000000 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 1.2511196             1.043348            0.5953746 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.0000000 #>          X54_Y-90..Fibroblast X49_Y-90..Fibroblast X51_Y-88..Fibroblast #> PDK4                0.6006019             0.000000             0.000000 #> TNFRSF17            0.0000000             0.000000             0.000000 #> ICAM3               0.0000000             0.000000             0.000000 #> FAP                 0.5617244             1.148495             1.239170 #> GZMB                0.0000000             0.000000             0.000000 #> TSC2                0.0000000             0.000000             1.146598 #>          X53_Y-88..Fibroblast X55_Y-85..Fibroblast X59_Y-86..Fibroblast #> PDK4                        0            1.7344996                    0 #> TNFRSF17                    0            0.0000000                    0 #> ICAM3                       0            0.0000000                    0 #> FAP                         0            0.0000000                    0 #> GZMB                        0            0.7868097                    0 #> TSC2                        0            0.0000000                    0 #>          X60_Y-86..Fibroblast X55_Y-86..Fibroblast X56_Y-86..Fibroblast #> PDK4                0.7740249            0.0000000             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.6916996            0.7210869             1.507364 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X57_Y-86..Fibroblast X57_Y-87..Fibroblast X56_Y-87..Fibroblast #> PDK4                0.7008988            0.0000000             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.8664945            0.7685865             1.572555 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X60_Y-87..Fibroblast X55_Y-87..Fibroblast X55_Y-88..Fibroblast #> PDK4                 2.515805            0.4297868             0.000000 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  0.000000            1.4753617             1.157027 #> GZMB                 0.000000            0.0000000             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X57_Y-88..Fibroblast X58_Y-88..Fibroblast X59_Y-89..Fibroblast #> PDK4                0.6636118            0.9290565             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 1.0100421            0.6454725             2.007925 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X58_Y-89..Fibroblast X57_Y-89..Fibroblast X56_Y-89..Fibroblast #> PDK4                 2.805053            0.9350176             0.845326 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  3.467481            1.9972311             1.427675 #> GZMB                 2.805053            0.9350176             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X55_Y-89..Fibroblast X60_Y-89..Fibroblast X56_Y-90..Fibroblast #> PDK4                0.8169405            0.9188316            0.4830434 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.6787461            0.7938436            1.4550970 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X57_Y-90..Fibroblast X60_Y-90..Fibroblast X58_Y-90..Fibroblast #> PDK4                0.8016631            1.6852616            0.8016631 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.8102795            1.7632592            1.7712671 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.9968292            0.0000000 #>          X58_Y-91..Fibroblast X55_Y-91..Fibroblast X59_Y-91..Fibroblast #> PDK4                 1.002079            0.0000000             1.839541 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  2.214084            0.7303435             0.000000 #> GZMB                 0.000000            0.0000000             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X58_Y-86..Fibroblast X59_Y-88..Fibroblast X55_Y-64..Fibroblast #> PDK4                 2.803595             0.000000                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  3.465978             1.424201                    0 #> GZMB                 0.000000             0.000000                    0 #> TSC2                 0.000000             0.000000                    0 #>          X56_Y-65..Fibroblast X55_Y-65..Fibroblast X57_Y-65..Fibroblast #> PDK4                0.9393739            0.4769138             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.9393739            0.0000000             1.760742 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X55_Y-66..Fibroblast X57_Y-66..Fibroblast X58_Y-66..Fibroblast #> PDK4                        0             0.000000             0.000000 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             1.757042             1.148884 #> GZMB                        0             0.000000             0.000000 #> TSC2                        0             0.000000             0.000000 #>          X71_Y-64..Fibroblast X73_Y-64..Fibroblast X71_Y-65..Fibroblast #> PDK4                 1.889804            0.0000000             1.367809 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  1.282947            0.0000000             1.837294 #> GZMB                 0.000000            0.8856529             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X67_Y-66..Fibroblast X73_Y-66..Fibroblast X72_Y-66..Fibroblast #> PDK4                 0.000000                    0                    0 #> TNFRSF17             0.000000                    0                    0 #> ICAM3                0.000000                    0                    0 #> FAP                  1.763229                    0                    0 #> GZMB                 0.000000                    0                    0 #> TSC2                 0.000000                    0                    0 #>          X72_Y-67..Fibroblast X72_Y-65..Fibroblast X52_Y-97..Fibroblast #> PDK4                0.0000000             0.000000              0.00000 #> TNFRSF17            0.0000000             0.000000              0.00000 #> ICAM3               0.0000000             0.000000              0.00000 #> FAP                 0.0000000             2.217389              1.99372 #> GZMB                0.0000000             0.000000              0.00000 #> TSC2                0.9994398             0.000000              0.00000 #>          X48_Y-98..Fibroblast X49_Y-98..Fibroblast X49_Y-99..Fibroblast #> PDK4                 0.000000            0.1895017            0.0000000 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  2.241371            0.4701419            0.2202963 #> GZMB                 0.000000            0.0000000            0.3417728 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X50_Y-99..Fibroblast X53_Y-99..Fibroblast X51_Y-99..Fibroblast #> PDK4                0.0000000            0.7564669            0.3656766 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.0701325            0.7298883            1.6788518 #> GZMB                0.4936718            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X52_Y-99..Fibroblast X51_Y-100..Fibroblast X53_Y-100..Fibroblast #> PDK4                0.3782335             0.7313531             0.5403655 #> TNFRSF17            0.0000000             0.0000000             0.0000000 #> ICAM3               0.0000000             0.0000000             0.0000000 #> FAP                 1.1163429             1.1768774             0.2432067 #> GZMB                0.0000000             0.0000000             0.0000000 #> TSC2                0.0000000             0.0000000             0.2234495 #>          X49_Y-100..Fibroblast X48_Y-100..Fibroblast X50_Y-100..Fibroblast #> PDK4                 1.2291951             0.5863666             0.5233383 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.4926147             1.1318731             0.4733341 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X52_Y-100..Fibroblast X49_Y-101..Fibroblast X50_Y-101..Fibroblast #> PDK4                 0.8713036             0.8840701             0.8722305 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.4222411             1.7059854 #> GZMB                 0.3456401             0.4834360             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X52_Y-101..Fibroblast X48_Y-101..Fibroblast X53_Y-101..Fibroblast #> PDK4                 0.6150735             1.3859546              1.573999 #> TNFRSF17             0.0000000             0.0000000              0.000000 #> ICAM3                0.0000000             0.0000000              0.000000 #> FAP                  0.5295958             0.0000000              0.000000 #> GZMB                 0.0000000             0.3760058              0.000000 #> TSC2                 0.0000000             0.3842776              0.000000 #>          X53_Y-102..Fibroblast X49_Y-102..Fibroblast X48_Y-102..Fibroblast #> PDK4                 0.9837491                     0             0.7298883 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.3915548                     0             0.0000000 #> GZMB                 0.0000000                     0             0.0000000 #> TSC2                 0.0000000                     0             0.0000000 #>          X52_Y-102..Fibroblast X51_Y-102..Fibroblast X50_Y-102..Fibroblast #> PDK4                 0.3053455              0.000000             0.0000000 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  1.1921367              2.181673             2.2321665 #> GZMB                 0.0000000              0.000000             0.6212216 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X49_Y-103..Fibroblast X51_Y-101..Fibroblast X47_Y-98..Fibroblast #> PDK4                  0.000000              0.000000             0.000000 #> TNFRSF17              0.000000              0.000000             0.000000 #> ICAM3                 0.000000              0.000000             0.000000 #> FAP                   1.138969              1.059192             1.311478 #> GZMB                  0.000000              0.000000             0.000000 #> TSC2                  0.000000              0.000000             0.000000 #>          X46_Y-98..Fibroblast X43_Y-98..Fibroblast X44_Y-99..Fibroblast #> PDK4                        0            0.3513731             0.000000 #> TNFRSF17                    0            0.0000000             0.000000 #> ICAM3                       0            0.0000000             0.000000 #> FAP                         0            0.4144908             0.463196 #> GZMB                        0            0.0000000             0.000000 #> TSC2                        0            0.0000000             0.000000 #>          X43_Y-99..Fibroblast X48_Y-99..Fibroblast X45_Y-99..Fibroblast #> PDK4                  0.00000                    0              0.00000 #> TNFRSF17              0.00000                    0              0.00000 #> ICAM3                 0.00000                    0              0.00000 #> FAP                   1.18004                    0              1.91316 #> GZMB                  0.00000                    0              0.00000 #> TSC2                  0.00000                    0              0.00000 #>          X43_Y-100..Fibroblast X45_Y-100..Fibroblast X44_Y-100..Fibroblast #> PDK4                 0.5248090             1.7239980             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.5677686             0.6377201             1.0420560 #> GZMB                 0.0000000             0.4549322             0.9203157 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X46_Y-100..Fibroblast X47_Y-100..Fibroblast X43_Y-101..Fibroblast #> PDK4                  0.514238             0.3856785             0.8207637 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   1.543306             1.1391150             0.9647810 #> GZMB                  0.000000             0.0000000             0.0000000 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X45_Y-101..Fibroblast X42_Y-101..Fibroblast X47_Y-101..Fibroblast #> PDK4                 0.6355150             0.4274901             0.5897791 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.7002347             0.5033148             0.6593061 #> GZMB                 0.5459186             0.0000000             0.4195564 #> TSC2                 0.0000000             0.0000000             0.3144089 #>          X44_Y-102..Fibroblast X43_Y-102..Fibroblast X47_Y-103..Fibroblast #> PDK4                  1.594328              0.000000             0.0000000 #> TNFRSF17              0.000000              0.000000             0.0000000 #> ICAM3                 0.000000              0.000000             0.0000000 #> FAP                   0.000000              1.637539             0.7632981 #> GZMB                  0.000000              0.000000             0.0000000 #> TSC2                  1.594328              0.000000             0.0000000 #>          X46_Y-101..Fibroblast X43_Y-103..Fibroblast X26_Y-92..Macrophage #> PDK4                  0.000000                     0             2.189387 #> TNFRSF17              0.000000                     0             0.000000 #> ICAM3                 0.000000                     0             0.000000 #> FAP                   1.167058                     0             0.000000 #> GZMB                  1.538374                     0             0.000000 #> TSC2                  0.000000                     0             0.000000 #>          X23_Y-92..Macrophage X28_Y-93..Macrophage X27_Y-93..Macrophage #> PDK4                        0             4.199363             2.799575 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             0.000000             0.000000 #> GZMB                        0             0.000000             0.000000 #> TSC2                        0             0.000000             0.000000 #>          X29_Y-94..Macrophage X25_Y-95..Macrophage X28_Y-95..Macrophage #> PDK4                        0             4.618426                    0 #> TNFRSF17                    0             0.000000                    0 #> ICAM3                       0             0.000000                    0 #> FAP                         0             0.000000                    0 #> GZMB                        0             0.000000                    0 #> TSC2                        0             0.000000                    0 #>          X27_Y-96..Macrophage X25_Y-96..Macrophage X26_Y-96..Macrophage #> PDK4                  0.00000            1.4664245             1.759709 #> TNFRSF17              0.00000            0.0000000             0.000000 #> ICAM3                 0.00000            0.0000000             0.000000 #> FAP                   0.00000            0.0000000             0.000000 #> GZMB                  1.15885            0.6325001             0.000000 #> TSC2                  0.00000            0.0000000             0.000000 #>          X24_Y-96..Macrophage X24_Y-97..Macrophage X26_Y-97..Macrophage #> PDK4                        0            1.4239816                    0 #> TNFRSF17                    0            0.0000000                    0 #> ICAM3                       0            0.0000000                    0 #> FAP                         0            0.0000000                    0 #> GZMB                        0            0.4792546                    0 #> TSC2                        0            0.4482441                    0 #>          X28_Y-94..Macrophage X24_Y-95..Macrophage X27_Y-95..Macrophage #> PDK4                 4.451387                    0              0.00000 #> TNFRSF17             0.000000                    0              0.00000 #> ICAM3                0.000000                    0              0.00000 #> FAP                  0.000000                    0              0.00000 #> GZMB                 0.000000                    0              1.15885 #> TSC2                 0.000000                    0              0.00000 #>          X62_Y-91..Macrophage X61_Y-91..Macrophage X64_Y-91..Macrophage #> PDK4                0.4836282            1.4258694             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.0000000            0.0000000             0.000000 #> GZMB                0.0000000            1.4562579             1.562333 #> TSC2                0.0000000            0.3565495             0.000000 #>          X63_Y-92..Macrophage X62_Y-92..Macrophage X61_Y-92..Macrophage #> PDK4                0.5502978            0.6607245            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            0.0000000            0.0000000 #> GZMB                0.0000000            0.0000000            0.6520674 #> TSC2                0.5574748            0.0000000            0.4584208 #>          X65_Y-92..Macrophage X64_Y-92..Macrophage X63_Y-93..Macrophage #> PDK4                        0                    0            1.1941480 #> TNFRSF17                    0                    0            0.0000000 #> ICAM3                       0                    0            0.0000000 #> FAP                         0                    0            0.0000000 #> GZMB                        0                    0            0.0000000 #> TSC2                        0                    0            0.6371141 #>          X64_Y-93..Macrophage X64_Y-94..Macrophage X61_Y-95..Macrophage #> PDK4                 1.166386             2.104024                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  0.000000             0.000000                    0 #> GZMB                 0.000000             0.000000                    0 #> TSC2                 0.000000             0.000000                    0 #>          X63_Y-95..Macrophage X64_Y-95..Macrophage X63_Y-96..Macrophage #> PDK4                 0.000000                    0                    0 #> TNFRSF17             0.000000                    0                    0 #> ICAM3                0.000000                    0                    0 #> FAP                  0.000000                    0                    0 #> GZMB                 2.170326                    0                    0 #> TSC2                 0.000000                    0                    0 #>          X60_Y-91..Macrophage X60_Y-92..Macrophage X61_Y-93..Macrophage #> PDK4                0.6711014             2.147261                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 0.0000000             0.000000                    0 #> GZMB                0.0000000             0.000000                    0 #> TSC2                0.0000000             0.000000                    0 #>          X62_Y-93..Macrophage X62_Y-94..Macrophage X62_Y-96..Macrophage #> PDK4                 0.000000             0.000000                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  0.000000             0.000000                    0 #> GZMB                 1.925955             0.000000                    0 #> TSC2                 2.213289             4.426577                    0 #>          X59_Y-91..Macrophage X57_Y-91..Macrophage X58_Y-91..Macrophage #> PDK4                0.9690034            0.0000000            1.1097872 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            0.0000000            0.0000000 #> GZMB                0.0000000            0.9774357            0.6981683 #> TSC2                0.0000000            0.9774357            0.6981683 #>          X57_Y-92..Macrophage X56_Y-92..Macrophage X58_Y-92..Macrophage #> PDK4                        0                    0            1.0697713 #> TNFRSF17                    0                    0            0.0000000 #> ICAM3                       0                    0            0.0000000 #> FAP                         0                    0            0.0000000 #> GZMB                        0                    0            0.8999245 #> TSC2                        0                    0            0.0000000 #>          X57_Y-93..Macrophage X59_Y-93..Macrophage X58_Y-93..Macrophage #> PDK4                        0            1.0406607            1.3875476 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.0000000            0.0000000 #> GZMB                        0            0.4499623            0.5999497 #> TSC2                        0            0.0000000            0.0000000 #>          X56_Y-93..Macrophage X54_Y-93..Macrophage X60_Y-93..Macrophage #> PDK4                 2.613055                    0                    0 #> TNFRSF17             0.000000                    0                    0 #> ICAM3                0.000000                    0                    0 #> FAP                  0.000000                    0                    0 #> GZMB                 0.000000                    0                    0 #> TSC2                 0.000000                    0                    0 #>          X59_Y-94..Macrophage X55_Y-94..Macrophage X57_Y-94..Macrophage #> PDK4                        0            1.2282688                    0 #> TNFRSF17                    0            0.0000000                    0 #> ICAM3                       0            0.0000000                    0 #> FAP                         0            0.0000000                    0 #> GZMB                        0            0.9188883                    0 #> TSC2                        0            0.0000000                    0 #>          X58_Y-94..Macrophage X55_Y-95..Macrophage X56_Y-95..Macrophage #> PDK4                 1.348733             1.245761            0.8488632 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  0.000000             0.000000            0.0000000 #> GZMB                 0.000000             0.000000            0.4019073 #> TSC2                 0.000000             0.000000            0.0000000 #>          X57_Y-95..Macrophage X58_Y-95..Macrophage X59_Y-95..Macrophage #> PDK4                0.8607933                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 0.0000000                    0                    0 #> GZMB                0.0000000                    0                    0 #> TSC2                0.0000000                    0                    0 #>          X56_Y-96..Macrophage X60_Y-96..Macrophage X57_Y-96..Macrophage #> PDK4                0.0000000            0.0000000            0.9596537 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            0.0000000            0.0000000 #> GZMB                0.0000000            0.9323278            0.4720003 #> TSC2                0.4413181            0.0000000            0.0000000 #>          X58_Y-97..Macrophage X56_Y-97..Macrophage X57_Y-97..Macrophage #> PDK4                        0                    0            0.0000000 #> TNFRSF17                    0                    0            0.0000000 #> ICAM3                       0                    0            0.0000000 #> FAP                         0                    0            0.0000000 #> GZMB                        0                    0            0.0000000 #> TSC2                        0                    0            0.3939276 #>          X55_Y-97..Macrophage X57_Y-98..Macrophage X56_Y-98..Macrophage #> PDK4                0.0000000            0.4495778            0.7040486 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            0.0000000            0.0000000 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.7536366            0.4814671            0.0000000 #>          X55_Y-91..Macrophage X59_Y-92..Macrophage X61_Y-96..Macrophage #> PDK4                0.0000000            1.0697713                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.0000000            0.0000000                    0 #> GZMB                0.7607077            0.8999245                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X60_Y-97..Macrophage X59_Y-97..Macrophage X75_Y-97..Macrophage #> PDK4                 1.189682              3.82734                    0 #> TNFRSF17             0.000000              0.00000                    0 #> ICAM3                0.000000              0.00000                    0 #> FAP                  0.000000              0.00000                    0 #> GZMB                 0.000000              0.00000                    0 #> TSC2                 0.000000              0.00000                    0 #>          X73_Y-97..Macrophage X78_Y-98..Macrophage X78_Y-99..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X77_Y-99..Macrophage X76_Y-100..Macrophage X74_Y-100..Macrophage #> PDK4                 0.000000              0.000000               4.71949 #> TNFRSF17             0.000000              0.000000               0.00000 #> ICAM3                0.000000              0.000000               0.00000 #> FAP                  0.000000              0.000000               0.00000 #> GZMB                 0.000000              0.000000               0.00000 #> TSC2                 1.396223              2.094335               0.00000 #>          X73_Y-101..Macrophage X78_Y-101..Macrophage X79_Y-102..Macrophage #> PDK4                  0.000000                     0                     0 #> TNFRSF17              0.000000                     0                     0 #> ICAM3                 0.000000                     0                     0 #> FAP                   0.000000                     0                     0 #> GZMB                  4.874205                     0                     0 #> TSC2                  0.000000                     0                     0 #>          X74_Y-102..Macrophage X78_Y-102..Macrophage X76_Y-104..Macrophage #> PDK4                         0                     0                     0 #> TNFRSF17                     0                     0                     0 #> ICAM3                        0                     0                     0 #> FAP                          0                     0                     0 #> GZMB                         0                     0                     0 #> TSC2                         0                     0                     0 #>          X77_Y-98..Macrophage X76_Y-98..Macrophage X74_Y-99..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X77_Y-104..Macrophage X78_Y-85..Macrophage X73_Y-87..Macrophage #> PDK4                         0                    0                    0 #> TNFRSF17                     0                    0                    0 #> ICAM3                        0                    0                    0 #> FAP                          0                    0                    0 #> GZMB                         0                    0                    0 #> TSC2                         0                    0                    0 #>          X76_Y-87..Macrophage X75_Y-87..Macrophage X76_Y-88..Macrophage #> PDK4                        0                    0             4.282601 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X74_Y-88..Macrophage X79_Y-88..Macrophage X77_Y-89..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X75_Y-90..Macrophage X78_Y-90..Macrophage X76_Y-90..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X77_Y-86..Macrophage X77_Y-87..Macrophage X75_Y-89..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X73_Y-89..Macrophage X77_Y-90..Macrophage X73_Y-91..Macrophage #> PDK4                        0             5.138686                    0 #> TNFRSF17                    0             0.000000                    0 #> ICAM3                       0             0.000000                    0 #> FAP                         0             0.000000                    0 #> GZMB                        0             0.000000                    0 #> TSC2                        0             0.000000                    0 #>          X29_Y-74..Macrophage X30_Y-74..Macrophage X32_Y-75..Macrophage #> PDK4                        0                    0             1.874679 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             1.874679 #>          X35_Y-76..Macrophage X31_Y-76..Macrophage X35_Y-78..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X32_Y-79..Macrophage X30_Y-73..Macrophage X31_Y-73..Macrophage #> PDK4                 2.368074                    0             0.000000 #> TNFRSF17             0.000000                    0             0.000000 #> ICAM3                0.000000                    0             0.000000 #> FAP                  0.000000                    0             0.000000 #> GZMB                 0.000000                    0             0.000000 #> TSC2                 0.000000                    0             4.241228 #>          X31_Y-74..Macrophage X31_Y-75..Macrophage X34_Y-78..Macrophage #> PDK4                 1.012934             1.012934                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  0.000000             0.000000                    0 #> GZMB                 0.000000             0.000000                    0 #> TSC2                 1.060307             0.000000                    0 #>          X32_Y-78..Macrophage X37_Y-68..Macrophage X39_Y-68..Macrophage #> PDK4                 2.368074             4.085632             1.852899 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  0.000000             0.000000             0.000000 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             0.000000 #>          X42_Y-68..Macrophage X42_Y-69..Macrophage X39_Y-69..Macrophage #> PDK4                        0                    0             2.197225 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X41_Y-69..Macrophage X40_Y-70..Macrophage X39_Y-70..Macrophage #> PDK4                        0             2.626083             4.462141 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             0.000000             0.000000 #> GZMB                        0             0.000000             0.000000 #> TSC2                        0             0.000000             0.000000 #>          X37_Y-70..Macrophage X36_Y-71..Macrophage X40_Y-71..Macrophage #> PDK4                 3.417678             4.406634            1.5574634 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  0.000000             0.000000            0.0000000 #> GZMB                 0.000000             0.000000            0.5553808 #> TSC2                 0.000000             0.000000            0.0000000 #>          X38_Y-71..Macrophage X39_Y-71..Macrophage X40_Y-72..Macrophage #> PDK4                        0                    0             1.318963 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X38_Y-72..Macrophage X41_Y-72..Macrophage X39_Y-73..Macrophage #> PDK4                        0             2.586486             1.384641 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             0.000000             0.000000 #> GZMB                        0             0.000000             0.000000 #> TSC2                        0             0.000000             0.000000 #>          X36_Y-69..Macrophage X38_Y-69..Macrophage X40_Y-73..Macrophage #> PDK4                 2.127412                    0            0.6953102 #> TNFRSF17             0.000000                    0            0.0000000 #> ICAM3                0.000000                    0            0.0000000 #> FAP                  0.000000                    0            0.0000000 #> GZMB                 0.000000                    0            0.0000000 #> TSC2                 0.000000                    0            0.0000000 #>          X42_Y-73..Macrophage X39_Y-74..Macrophage X38_Y-74..Macrophage #> PDK4                 3.485709             1.723327             2.387494 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  0.000000             0.000000             0.000000 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             0.000000 #>          X36_Y-75..Macrophage X38_Y-75..Macrophage X40_Y-75..Macrophage #> PDK4                        0             4.125416                    0 #> TNFRSF17                    0             0.000000                    0 #> ICAM3                       0             0.000000                    0 #> FAP                         0             0.000000                    0 #> GZMB                        0             0.000000                    0 #> TSC2                        0             0.000000                    0 #>          X37_Y-75..Macrophage X41_Y-76..Macrophage X38_Y-76..Macrophage #> PDK4                 3.155804             4.887178                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  0.000000             0.000000                    0 #> GZMB                 0.000000             0.000000                    0 #> TSC2                 0.000000             0.000000                    0 #>          X42_Y-77..Macrophage X36_Y-78..Macrophage X40_Y-78..Macrophage #> PDK4                  3.16435                    0                    0 #> TNFRSF17              0.00000                    0                    0 #> ICAM3                 0.00000                    0                    0 #> FAP                   0.00000                    0                    0 #> GZMB                  0.00000                    0                    0 #> TSC2                  0.00000                    0                    0 #>          X41_Y-78..Macrophage X38_Y-78..Macrophage X37_Y-78..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X42_Y-78..Macrophage X37_Y-79..Macrophage X38_Y-73..Macrophage #> PDK4                        0                    0             1.425194 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X78_Y-72..Macrophage X78_Y-73..Macrophage X77_Y-73..Macrophage #> PDK4                        0             1.918412            0.6106911 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             0.000000            0.0000000 #> GZMB                        0             0.000000            0.5462550 #> TSC2                        0             0.000000            0.0000000 #>          X73_Y-73..Macrophage X79_Y-73..Macrophage X76_Y-74..Macrophage #> PDK4                 1.432864             1.098291             0.000000 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  0.000000             0.000000             0.000000 #> GZMB                 0.000000             0.000000             1.449386 #> TSC2                 0.000000             0.000000             0.000000 #>          X73_Y-74..Macrophage X78_Y-74..Macrophage X77_Y-74..Macrophage #> PDK4                 1.704949             1.315548            0.5234495 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  0.000000             0.000000            0.0000000 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X74_Y-74..Macrophage X73_Y-75..Macrophage X76_Y-75..Macrophage #> PDK4                        0             1.459591            0.7616073 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             0.000000            0.0000000 #> GZMB                        0             0.000000            0.0000000 #> TSC2                        0             0.000000            0.0000000 #>          X77_Y-75..Macrophage X75_Y-75..Macrophage X76_Y-76..Macrophage #> PDK4                        0             1.434655             1.195528 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             0.000000             0.000000 #> GZMB                        0             0.000000             0.000000 #> TSC2                        0             0.000000             0.000000 #>          X77_Y-76..Macrophage X78_Y-76..Macrophage X77_Y-77..Macrophage #> PDK4                0.6276173                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 0.0000000                    0                    0 #> GZMB                0.0000000                    0                    0 #> TSC2                0.0000000                    0                    0 #>          X76_Y-77..Macrophage X74_Y-77..Macrophage X78_Y-77..Macrophage #> PDK4                 1.615775             4.485477            0.0000000 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  0.000000             0.000000            0.0000000 #> GZMB                 0.000000             4.485477            0.0000000 #> TSC2                 0.000000             0.000000            0.4610182 #>          X78_Y-78..Macrophage X76_Y-78..Macrophage X75_Y-78..Macrophage #> PDK4                        0              1.02624            0.8666407 #> TNFRSF17                    0              0.00000            0.0000000 #> ICAM3                       0              0.00000            0.0000000 #> FAP                         0              0.00000            0.0000000 #> GZMB                        0              0.00000            0.0000000 #> TSC2                        0              0.00000            0.0000000 #>          X74_Y-78..Macrophage X77_Y-79..Macrophage X75_Y-79..Macrophage #> PDK4                 4.275582                    0             1.083301 #> TNFRSF17             0.000000                    0             0.000000 #> ICAM3                0.000000                    0             0.000000 #> FAP                  0.000000                    0             0.000000 #> GZMB                 0.000000                    0             1.081453 #> TSC2                 0.000000                    0             0.000000 #>          X73_Y-72..Macrophage X74_Y-73..Macrophage X78_Y-75..Macrophage #> PDK4                1.0733668             1.141706                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 0.0000000             0.000000                    0 #> GZMB                0.0000000             0.000000                    0 #> TSC2                0.3959747             0.000000                    0 #>          X78_Y-79..Macrophage X64_Y-67..Macrophage X66_Y-68..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X62_Y-69..Macrophage X62_Y-70..Macrophage X64_Y-72..Macrophage #> PDK4                 3.539359                    0                    0 #> TNFRSF17             0.000000                    0                    0 #> ICAM3                0.000000                    0                    0 #> FAP                  0.000000                    0                    0 #> GZMB                 0.000000                    0                    0 #> TSC2                 0.000000                    0                    0 #>          X65_Y-73..Macrophage X66_Y-73..Macrophage X62_Y-68..Macrophage #> PDK4                        0             0.000000             1.769679 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             0.000000             0.000000 #> GZMB                        0             1.422871             0.000000 #> TSC2                        0             0.000000             0.000000 #>          X63_Y-70..Macrophage X65_Y-71..Macrophage X63_Y-71..Macrophage #> PDK4                        0             4.138814                    0 #> TNFRSF17                    0             0.000000                    0 #> ICAM3                       0             0.000000                    0 #> FAP                         0             0.000000                    0 #> GZMB                        0             0.000000                    0 #> TSC2                        0             0.000000                    0 #>          X64_Y-71..Macrophage X65_Y-72..Macrophage X66_Y-72..Macrophage #> PDK4                        0                    0             0.000000 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             1.067153 #> TSC2                        0                    0             0.000000 #>          X63_Y-73..Macrophage X64_Y-74..Macrophage X65_Y-74..Macrophage #> PDK4                0.0000000            1.1694664                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.0000000            0.0000000                    0 #> GZMB                0.7482577            0.6113098                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X65_Y-75..Macrophage X66_Y-75..Macrophage X67_Y-75..Macrophage #> PDK4                0.7185323                    0            0.9210538 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.0000000                    0            0.0000000 #> GZMB                0.0000000                    0            0.0000000 #> TSC2                0.0000000                    0            0.0000000 #>          X61_Y-75..Macrophage X62_Y-76..Macrophage X65_Y-76..Macrophage #> PDK4                        0                    0            0.8622388 #> TNFRSF17                    0                    0            0.0000000 #> ICAM3                       0                    0            0.0000000 #> FAP                         0                    0            0.0000000 #> GZMB                        0                    0            0.0000000 #> TSC2                        0                    0            0.0000000 #>          X66_Y-77..Macrophage X61_Y-78..Macrophage X63_Y-74..Macrophage #> PDK4                 1.232696             3.795001            0.4784200 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  0.000000             0.000000            0.0000000 #> GZMB                 0.000000             0.000000            0.5344698 #> TSC2                 0.000000             0.000000            0.0000000 #>          X67_Y-77..Macrophage X72_Y-72..Macrophage X72_Y-73..Macrophage #> PDK4                        0            1.0272769            0.6326516 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.0000000            0.0000000 #> GZMB                        0            0.6158943            0.0000000 #> TSC2                        0            0.0000000            0.0000000 #>          X68_Y-73..Macrophage X67_Y-73..Macrophage X68_Y-74..Macrophage #> PDK4                0.4134899            1.1520496            0.3649441 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            0.0000000            0.0000000 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.5318148            0.0000000 #>          X72_Y-74..Macrophage X67_Y-74..Macrophage X69_Y-74..Macrophage #> PDK4                0.0000000            0.6700773            2.1043088 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            0.0000000            0.0000000 #> GZMB                0.0000000            0.0000000            0.8806003 #> TSC2                0.7432998            0.0000000            0.0000000 #>          X69_Y-75..Macrophage X72_Y-75..Macrophage X71_Y-75..Macrophage #> PDK4                1.8036933             1.459591            0.0000000 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.0000000             0.000000            0.0000000 #> GZMB                0.7548003             0.000000            0.0000000 #> TSC2                0.0000000             1.486600            0.8919597 #>          X70_Y-75..Macrophage X67_Y-76..Macrophage X70_Y-76..Macrophage #> PDK4                0.7046366            0.6022974            0.5745936 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            0.0000000            0.0000000 #> GZMB                0.0000000            0.0000000            0.2617247 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X68_Y-76..Macrophage X71_Y-76..Macrophage X69_Y-76..Macrophage #> PDK4                 1.332164            0.8048759             1.836656 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  0.000000            0.0000000             0.000000 #> GZMB                 0.000000            0.3664146             0.000000 #> TSC2                 0.000000            0.3162282             0.000000 #>          X66_Y-76..Macrophage X68_Y-77..Macrophage X70_Y-77..Macrophage #> PDK4                 1.849044            1.1840513                    0 #> TNFRSF17             0.000000            0.0000000                    0 #> ICAM3                0.000000            0.0000000                    0 #> FAP                  0.000000            0.0000000                    0 #> GZMB                 0.000000            0.2638755                    0 #> TSC2                 0.000000            0.0000000                    0 #>          X69_Y-77..Macrophage X70_Y-78..Macrophage X71_Y-78..Macrophage #> PDK4                 1.435565            0.9544703            1.9263941 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.000000            0.0000000            0.0000000 #> GZMB                 0.000000            0.4445749            0.5927665 #> TSC2                 0.000000            0.2230654            0.0000000 #>          X72_Y-78..Macrophage X70_Y-79..Macrophage X71_Y-79..Macrophage #> PDK4                 1.096645            1.3222012            1.7215451 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.000000            0.0000000            0.0000000 #> GZMB                 0.000000            0.5379443            0.5763689 #> TSC2                 0.000000            0.2841130            0.3044067 #>          X68_Y-75..Macrophage X72_Y-76..Macrophage X73_Y-78..Macrophage #> PDK4                  2.21088                    0                    0 #> TNFRSF17              0.00000                    0                    0 #> ICAM3                 0.00000                    0                    0 #> FAP                   0.00000                    0                    0 #> GZMB                  1.32090                    0                    0 #> TSC2                  0.00000                    0                    0 #>          X69_Y-78..Macrophage X57_Y-73..Macrophage X55_Y-75..Macrophage #> PDK4                 0.465669                    0             1.909333 #> TNFRSF17             0.000000                    0             0.000000 #> ICAM3                0.000000                    0             0.000000 #> FAP                  0.000000                    0             0.000000 #> GZMB                 0.000000                    0             0.000000 #> TSC2                 0.000000                    0             0.000000 #>          X54_Y-76..Macrophage X58_Y-76..Macrophage X54_Y-77..Macrophage #> PDK4                0.6698315             1.756865            0.0000000 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.0000000             0.000000            0.0000000 #> GZMB                0.6628311             0.000000            0.7953974 #> TSC2                0.0000000             0.000000            0.8390173 #>          X55_Y-77..Macrophage X60_Y-78..Macrophage X59_Y-78..Macrophage #> PDK4                0.0000000             1.355521                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 0.0000000             0.000000                    0 #> GZMB                0.7923393             0.000000                    0 #> TSC2                0.0000000             0.000000                    0 #>          X55_Y-78..Macrophage X56_Y-79..Macrophage X59_Y-75..Macrophage #> PDK4                0.0000000                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 0.0000000                    0                    0 #> GZMB                0.6602827                    0                    0 #> TSC2                0.0000000                    0                    0 #>          X58_Y-75..Macrophage X73_Y-66..Macrophage X72_Y-67..Macrophage #> PDK4                 1.171244             1.085297            1.2456563 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  0.000000             0.000000            0.0000000 #> GZMB                 0.000000             0.000000            0.2373406 #> TSC2                 0.000000             0.000000            0.0000000 #>          X73_Y-67..Macrophage X68_Y-67..Macrophage X71_Y-67..Macrophage #> PDK4                0.6931254                    0             0.000000 #> TNFRSF17            0.0000000                    0             0.000000 #> ICAM3               0.0000000                    0             0.000000 #> FAP                 0.0000000                    0             0.000000 #> GZMB                0.2804934                    0             0.000000 #> TSC2                0.0000000                    0             3.761591 #>          X72_Y-68..Macrophage X73_Y-68..Macrophage X68_Y-68..Macrophage #> PDK4                 0.000000            0.5779682             1.826548 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  0.000000            0.0000000             0.000000 #> GZMB                 0.507425            0.2854266             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X72_Y-69..Macrophage X69_Y-69..Macrophage X72_Y-70..Macrophage #> PDK4                0.3950819             1.217699            0.6486264 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.0000000             0.000000            0.0000000 #> GZMB                0.4230929             0.000000            0.3461670 #> TSC2                0.0000000             0.000000            0.0000000 #>          X71_Y-70..Macrophage X73_Y-70..Macrophage X70_Y-70..Macrophage #> PDK4                0.7111473            0.8947885                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.0000000            0.0000000                    0 #> GZMB                0.0000000            0.0000000                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X72_Y-71..Macrophage X67_Y-71..Macrophage X73_Y-71..Macrophage #> PDK4                0.9131350            0.8914254            0.7669377 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            0.0000000            0.0000000 #> GZMB                0.5474616            0.0000000            0.4479231 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X68_Y-72..Macrophage X67_Y-72..Macrophage X69_Y-68..Macrophage #> PDK4                0.0000000            0.0000000             3.653096 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.0000000            0.0000000             0.000000 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.8676237            0.5784158             0.000000 #>          X68_Y-70..Macrophage X54_Y-72..Macrophage X48_Y-73..Macrophage #> PDK4                 4.068535                    0             1.008806 #> TNFRSF17             0.000000                    0             0.000000 #> ICAM3                0.000000                    0             0.000000 #> FAP                  0.000000                    0             0.000000 #> GZMB                 0.000000                    0             0.000000 #> TSC2                 0.000000                    0             0.000000 #>          X53_Y-73..Macrophage X52_Y-73..Macrophage X49_Y-73..Macrophage #> PDK4                 1.396665            1.2392282                    0 #> TNFRSF17             0.000000            0.0000000                    0 #> ICAM3                0.000000            0.0000000                    0 #> FAP                  0.000000            0.0000000                    0 #> GZMB                 0.000000            0.5701401                    0 #> TSC2                 0.000000            0.2304150                    0 #>          X51_Y-73..Macrophage X52_Y-74..Macrophage X50_Y-74..Macrophage #> PDK4                0.9679283            1.3440690             1.545712 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.0000000            0.0000000             0.000000 #> GZMB                1.1111064            0.2330604             0.000000 #> TSC2                0.4608299            0.2048133             0.000000 #>          X51_Y-74..Macrophage X53_Y-74..Macrophage X53_Y-75..Macrophage #> PDK4                 0.000000            0.7777989                    0 #> TNFRSF17             0.000000            0.0000000                    0 #> ICAM3                0.000000            0.0000000                    0 #> FAP                  0.000000            0.0000000                    0 #> GZMB                 1.320565            0.4195087                    0 #> TSC2                 0.000000            0.0000000                    0 #>          X54_Y-75..Macrophage X53_Y-76..Macrophage X49_Y-78..Macrophage #> PDK4                        0             1.004747            0.5056399 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             0.000000            0.0000000 #> GZMB                        0             0.000000            0.5383177 #> TSC2                        0             0.000000            0.0000000 #>          X54_Y-78..Macrophage X48_Y-78..Macrophage X52_Y-78..Macrophage #> PDK4                        0             1.236653            0.3920641 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             0.000000            0.0000000 #> GZMB                        0             0.271245            0.0000000 #> TSC2                        0             0.000000            0.0000000 #>          X53_Y-78..Macrophage X50_Y-78..Macrophage X54_Y-79..Macrophage #> PDK4                1.2393341            0.3630847            0.8548446 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            0.0000000            0.0000000 #> GZMB                0.8888926            0.3630847            0.0000000 #> TSC2                0.2915969            0.0000000            0.0000000 #>          X50_Y-79..Macrophage X51_Y-79..Macrophage X48_Y-79..Macrophage #> PDK4                0.0000000            0.0000000                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.0000000            0.0000000                    0 #> GZMB                0.6044792            0.6554841                    0 #> TSC2                0.0000000            0.2071939                    0 #>          X52_Y-79..Macrophage X49_Y-79..Macrophage X52_Y-72..Macrophage #> PDK4                0.3899701            0.7356189            0.9787459 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            0.0000000            0.0000000 #> GZMB                0.0000000            0.0000000            1.5664696 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X48_Y-77..Macrophage X51_Y-78..Macrophage X53_Y-79..Macrophage #> PDK4                 1.551083                    0            0.4815653 #> TNFRSF17             0.000000                    0            0.0000000 #> ICAM3                0.000000                    0            0.0000000 #> FAP                  0.000000                    0            0.0000000 #> GZMB                 0.000000                    0            0.4850353 #> TSC2                 0.000000                    0            0.0000000 #>          X43_Y-91..Macrophage X47_Y-91..Macrophage X42_Y-91..Macrophage #> PDK4                 1.928342             0.755739            0.5904352 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  0.000000             0.000000            0.0000000 #> GZMB                 0.000000             0.000000            1.3338738 #> TSC2                 0.000000             0.000000            0.0000000 #>          X44_Y-91..Macrophage X48_Y-92..Macrophage X47_Y-92..Macrophage #> PDK4                 1.928342            0.0000000            2.3154210 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.000000            0.0000000            0.0000000 #> GZMB                 0.000000            0.0000000            0.5305103 #> TSC2                 0.000000            0.2422594            0.0000000 #>          X46_Y-92..Macrophage X44_Y-93..Macrophage X46_Y-93..Macrophage #> PDK4                2.2636091                    0              1.41815 #> TNFRSF17            0.0000000                    0              0.00000 #> ICAM3               0.0000000                    0              0.00000 #> FAP                 0.0000000                    0              0.00000 #> GZMB                0.7427144                    0              0.00000 #> TSC2                0.0000000                    0              0.00000 #>          X44_Y-94..Macrophage X46_Y-94..Macrophage X48_Y-94..Macrophage #> PDK4                        0              1.44708                    0 #> TNFRSF17                    0              0.00000                    0 #> ICAM3                       0              0.00000                    0 #> FAP                         0              0.00000                    0 #> GZMB                        0              0.00000                    0 #> TSC2                        0              0.00000                    0 #>          X45_Y-94..Macrophage X44_Y-95..Macrophage X46_Y-95..Macrophage #> PDK4                        0                    0             2.636142 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X46_Y-96..Macrophage X45_Y-96..Macrophage X47_Y-96..Macrophage #> PDK4                        0                    0            0.7913306 #> TNFRSF17                    0                    0            0.0000000 #> ICAM3                       0                    0            0.0000000 #> FAP                         0                    0            0.0000000 #> GZMB                        0                    0            0.0000000 #> TSC2                        0                    0            0.0000000 #>          X46_Y-97..Macrophage X44_Y-97..Macrophage X44_Y-98..Macrophage #> PDK4                        0                    0             1.852497 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X48_Y-91..Macrophage X44_Y-92..Macrophage X47_Y-94..Macrophage #> PDK4                0.4890076                    0             1.964683 #> TNFRSF17            0.0000000                    0             0.000000 #> ICAM3               0.0000000                    0             0.000000 #> FAP                 0.0000000                    0             0.000000 #> GZMB                0.0000000                    0             0.000000 #> TSC2                0.1852572                    0             0.000000 #>          X48_Y-95..Macrophage X45_Y-95..Macrophage X47_Y-97..Macrophage #> PDK4                  1.22888                    0            0.9596186 #> TNFRSF17              0.00000                    0            0.0000000 #> ICAM3                 0.00000                    0            0.0000000 #> FAP                   0.00000                    0            0.0000000 #> GZMB                  0.00000                    0            0.0000000 #> TSC2                  0.00000                    0            0.0000000 #>          X48_Y-97..Macrophage X22_Y-74..Macrophage X23_Y-77..Macrophage #> PDK4                 1.919237                    0                    0 #> TNFRSF17             0.000000                    0                    0 #> ICAM3                0.000000                    0                    0 #> FAP                  0.000000                    0                    0 #> GZMB                 0.000000                    0                    0 #> TSC2                 0.000000                    0                    0 #>          X22_Y-78..Macrophage X23_Y-79..Macrophage X22_Y-79..Macrophage #> PDK4                 2.451139             1.293121                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  0.000000             0.000000                    0 #> GZMB                 0.000000             0.000000                    0 #> TSC2                 0.000000             0.000000                    0 #>          X24_Y-77..Macrophage X24_Y-73..Macrophage X26_Y-73..Macrophage #> PDK4                 2.217389             1.404865                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  0.000000             0.000000                    0 #> GZMB                 0.000000             0.000000                    0 #> TSC2                 0.000000             0.000000                    0 #>          X26_Y-74..Macrophage X28_Y-74..Macrophage X27_Y-75..Macrophage #> PDK4                 1.117198                    0                    0 #> TNFRSF17             0.000000                    0                    0 #> ICAM3                0.000000                    0                    0 #> FAP                  0.000000                    0                    0 #> GZMB                 0.000000                    0                    0 #> TSC2                 0.000000                    0                    0 #>          X26_Y-75..Macrophage X24_Y-76..Macrophage X25_Y-76..Macrophage #> PDK4                        0              2.11725             2.695471 #> TNFRSF17                    0              0.00000             0.000000 #> ICAM3                       0              0.00000             0.000000 #> FAP                         0              0.00000             0.000000 #> GZMB                        0              0.00000             0.000000 #> TSC2                        0              0.00000             0.000000 #>          X26_Y-78..Macrophage X25_Y-73..Macrophage X28_Y-76..Macrophage #> PDK4                        0                    0             3.679083 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X25_Y-77..Macrophage X27_Y-78..Macrophage X26_Y-79..Macrophage #> PDK4                 2.762229                    0                    0 #> TNFRSF17             0.000000                    0                    0 #> ICAM3                0.000000                    0                    0 #> FAP                  0.000000                    0                    0 #> GZMB                 0.000000                    0                    0 #> TSC2                 0.000000                    0                    0 #>          X31_Y-69..Macrophage X34_Y-71..Macrophage X30_Y-72..Macrophage #> PDK4                        0             2.914829             2.692035 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             0.000000             0.000000 #> GZMB                        0             0.000000             0.000000 #> TSC2                        0             0.000000             0.000000 #>          X33_Y-67..Macrophage X30_Y-68..Macrophage X33_Y-70..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X33_Y-71..Macrophage X35_Y-71..Macrophage X31_Y-72..Macrophage #> PDK4                 3.481555             2.418141                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  0.000000             0.000000                    0 #> GZMB                 0.000000             0.000000                    0 #> TSC2                 0.000000             0.000000                    0 #>          X32_Y-72..Macrophage X33_Y-72..Macrophage X33_Y-73..Macrophage #> PDK4                 0.000000              4.91864                    0 #> TNFRSF17             0.000000              0.00000                    0 #> ICAM3                0.000000              0.00000                    0 #> FAP                  0.000000              0.00000                    0 #> GZMB                 0.000000              0.00000                    0 #> TSC2                 2.365282              0.00000                    0 #>          X32_Y-65..Macrophage X30_Y-79..Macrophage X31_Y-79..Macrophage #> PDK4                        0             1.954271              1.45981 #> TNFRSF17                    0             0.000000              0.00000 #> ICAM3                       0             0.000000              0.00000 #> FAP                         0             0.000000              0.00000 #> GZMB                        0             0.000000              0.00000 #> TSC2                        0             0.000000              0.00000 #>          X34_Y-80..Macrophage X30_Y-80..Macrophage X31_Y-80..Macrophage #> PDK4                 0.000000                    0             1.958616 #> TNFRSF17             0.000000                    0             0.000000 #> ICAM3                0.000000                    0             0.000000 #> FAP                  0.000000                    0             0.000000 #> GZMB                 0.000000                    0             0.000000 #> TSC2                 2.100773                    0             0.000000 #>          X35_Y-81..Macrophage X35_Y-83..Macrophage X33_Y-83..Macrophage #> PDK4                 1.978327            0.5703606             4.416373 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  0.000000            0.0000000             0.000000 #> GZMB                 0.000000            0.5162352             0.000000 #> TSC2                 1.978327            0.0000000             0.000000 #>          X31_Y-83..Macrophage X34_Y-83..Macrophage X34_Y-84..Macrophage #> PDK4                 1.286991            2.2244917             2.295338 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  0.000000            0.0000000             0.000000 #> GZMB                 0.000000            0.0000000             0.000000 #> TSC2                 0.000000            0.6481151             0.000000 #>          X33_Y-84..Macrophage X30_Y-84..Macrophage X35_Y-84..Macrophage #> PDK4                 4.062903                    0            0.9981310 #> TNFRSF17             0.000000                    0            0.0000000 #> ICAM3                0.000000                    0            0.0000000 #> FAP                  0.000000                    0            0.0000000 #> GZMB                 0.000000                    0            0.9034115 #> TSC2                 0.000000                    0            0.0000000 #>          X33_Y-85..Macrophage X32_Y-80..Macrophage X35_Y-80..Macrophage #> PDK4                  3.08498                    0             0.000000 #> TNFRSF17              0.00000                    0             0.000000 #> ICAM3                 0.00000                    0             0.000000 #> FAP                   0.00000                    0             0.000000 #> GZMB                  0.00000                    0             0.000000 #> TSC2                  0.00000                    0             1.400515 #>          X33_Y-81..Macrophage X34_Y-82..Macrophage X40_Y-65..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X41_Y-65..Macrophage X41_Y-66..Macrophage X40_Y-66..Macrophage #> PDK4                        0              1.03319             2.066379 #> TNFRSF17                    0              0.00000             0.000000 #> ICAM3                       0              0.00000             0.000000 #> FAP                         0              0.00000             0.000000 #> GZMB                        0              0.00000             0.000000 #> TSC2                        0              0.00000             0.000000 #>          X22_Y-67..Macrophage X23_Y-69..Macrophage X23_Y-70..Macrophage #> PDK4                        0             1.539079                    0 #> TNFRSF17                    0             0.000000                    0 #> ICAM3                       0             0.000000                    0 #> FAP                         0             0.000000                    0 #> GZMB                        0             0.000000                    0 #> TSC2                        0             0.000000                    0 #>          X22_Y-69..Macrophage X27_Y-80..Macrophage X29_Y-80..Macrophage #> PDK4                        0             4.133923                    0 #> TNFRSF17                    0             0.000000                    0 #> ICAM3                       0             0.000000                    0 #> FAP                         0             0.000000                    0 #> GZMB                        0             0.000000                    0 #> TSC2                        0             0.000000                    0 #>          X25_Y-80..Macrophage X29_Y-81..Macrophage X26_Y-81..Macrophage #> PDK4                        0                    0             2.907347 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X26_Y-82..Macrophage X24_Y-79..Macrophage X28_Y-80..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X26_Y-80..Macrophage X23_Y-81..Macrophage X26_Y-66..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X25_Y-66..Macrophage X25_Y-67..Macrophage X27_Y-67..Macrophage #> PDK4                 1.009489             1.009489            0.8509649 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  0.000000             0.000000            0.0000000 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X24_Y-67..Macrophage X27_Y-68..Macrophage X26_Y-68..Macrophage #> PDK4                        0            0.3427122            0.6283057 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.0000000            0.0000000 #> GZMB                        0            0.0000000            0.0000000 #> TSC2                        0            0.0000000            0.0000000 #>          X27_Y-69..Macrophage X26_Y-69..Macrophage X25_Y-69..Macrophage #> PDK4                        0                    0             2.543437 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X29_Y-70..Macrophage X25_Y-71..Macrophage X28_Y-71..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X26_Y-72..Macrophage X25_Y-72..Macrophage X26_Y-67..Macrophage #> PDK4                        0             2.107297            0.8326417 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             0.000000            0.0000000 #> GZMB                        0             0.000000            0.0000000 #> TSC2                        0             0.000000            0.0000000 #>          X25_Y-68..Macrophage X29_Y-68..Macrophage X29_Y-71..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X28_Y-72..Macrophage X22_Y-80..Macrophage X24_Y-80..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X22_Y-83..Macrophage X45_Y-64..Macrophage X44_Y-65..Macrophage #> PDK4                        0                    0             1.214058 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X47_Y-65..Macrophage X48_Y-65..Macrophage X45_Y-65..Macrophage #> PDK4                0.8508801             1.657721            0.6157095 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.0000000             0.000000            0.0000000 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.0000000 #>          X43_Y-65..Macrophage X44_Y-66..Macrophage X47_Y-66..Macrophage #> PDK4                 0.000000                    0             1.107853 #> TNFRSF17             0.000000                    0             0.000000 #> ICAM3                0.000000                    0             0.000000 #> FAP                  0.000000                    0             0.000000 #> GZMB                 0.000000                    0             0.000000 #> TSC2                 1.750587                    0             0.000000 #>          X43_Y-66..Macrophage X45_Y-66..Macrophage X48_Y-66..Macrophage #> PDK4                 0.000000             0.410473             1.657721 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  0.000000             0.000000             0.000000 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 1.750587             0.000000             0.000000 #>          X46_Y-67..Macrophage X44_Y-64..Macrophage X48_Y-64..Macrophage #> PDK4                0.9105434             1.214058                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 0.0000000             0.000000                    0 #> GZMB                0.0000000             0.000000                    0 #> TSC2                0.8080063             0.000000                    0 #>          X54_Y-64..Macrophage X54_Y-65..Macrophage X53_Y-65..Macrophage #> PDK4                 2.572119             2.630786             2.108227 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  0.000000             0.000000             0.000000 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             0.000000 #>          X49_Y-65..Macrophage X51_Y-65..Macrophage X52_Y-65..Macrophage #> PDK4                 4.455584            0.9672564             1.480414 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  0.000000            0.0000000             0.000000 #> GZMB                 3.773983            0.0000000             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X50_Y-65..Macrophage X53_Y-66..Macrophage X52_Y-66..Macrophage #> PDK4                 4.103037             2.220642             3.512728 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  0.000000             0.000000             0.000000 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             0.000000 #>          X51_Y-67..Macrophage X52_Y-67..Macrophage X49_Y-64..Macrophage #> PDK4                1.3467580            1.8651286             2.227792 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.0000000            0.0000000             0.000000 #> GZMB                0.2285623            0.2666561             1.886991 #> TSC2                0.2481084            0.2894598             0.000000 #>          X51_Y-66..Macrophage X40_Y-79..Macrophage X42_Y-79..Macrophage #> PDK4                        0             3.987317              2.62049 #> TNFRSF17                    0             0.000000              0.00000 #> ICAM3                       0             0.000000              0.00000 #> FAP                         0             0.000000              0.00000 #> GZMB                        0             0.000000              0.00000 #> TSC2                        0             0.000000              0.00000 #>          X37_Y-80..Macrophage X41_Y-80..Macrophage X40_Y-80..Macrophage #> PDK4                        0                    0             0.000000 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             1.942008 #>          X39_Y-80..Macrophage X41_Y-81..Macrophage X37_Y-81..Macrophage #> PDK4                        0                    0              2.35427 #> TNFRSF17                    0                    0              0.00000 #> ICAM3                       0                    0              0.00000 #> FAP                         0                    0              0.00000 #> GZMB                        0                    0              0.00000 #> TSC2                        0                    0              0.00000 #>          X38_Y-81..Macrophage X42_Y-81..Macrophage X38_Y-82..Macrophage #> PDK4                 3.364981             1.237857              1.86864 #> TNFRSF17             0.000000             0.000000              0.00000 #> ICAM3                0.000000             0.000000              0.00000 #> FAP                  0.000000             0.000000              0.00000 #> GZMB                 0.000000             0.000000              0.00000 #> TSC2                 0.000000             0.000000              0.00000 #>          X40_Y-82..Macrophage X41_Y-82..Macrophage X36_Y-82..Macrophage #> PDK4                 2.740091             1.075788                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  0.000000             0.000000                    0 #> GZMB                 0.000000             1.506933                    0 #> TSC2                 0.000000             0.000000                    0 #>          X37_Y-82..Macrophage X38_Y-83..Macrophage X39_Y-83..Macrophage #> PDK4                 3.860974             3.737279                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  0.000000             0.000000                    0 #> GZMB                 0.000000             0.000000                    0 #> TSC2                 0.000000             0.000000                    0 #>          X41_Y-83..Macrophage X36_Y-83..Macrophage X40_Y-83..Macrophage #> PDK4                 1.614702            0.6265407             4.295383 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  0.000000            0.0000000             0.000000 #> GZMB                 0.000000            0.0000000             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X37_Y-83..Macrophage X37_Y-84..Macrophage X39_Y-84..Macrophage #> PDK4                 1.039657             1.731857             3.029411 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  0.000000             0.000000             0.000000 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             0.000000 #>          X41_Y-84..Macrophage X36_Y-85..Macrophage X41_Y-85..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X40_Y-81..Macrophage X39_Y-82..Macrophage X36_Y-84..Macrophage #> PDK4                 0.000000             2.264917              0.00000 #> TNFRSF17             0.000000             0.000000              0.00000 #> ICAM3                0.000000             0.000000              0.00000 #> FAP                  0.000000             0.000000              0.00000 #> GZMB                 0.000000             0.000000              0.47842 #> TSC2                 1.942008             0.000000              0.00000 #>          X79_Y-69..Macrophage X45_Y-72..Macrophage X43_Y-73..Macrophage #> PDK4                        0                    0             1.096629 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X44_Y-73..Macrophage X46_Y-73..Macrophage X45_Y-73..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X47_Y-74..Macrophage X46_Y-74..Macrophage X48_Y-74..Macrophage #> PDK4                0.4697577             1.409273                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 0.0000000             0.000000                    0 #> GZMB                0.9479096             1.489428                    0 #> TSC2                0.0000000             0.000000                    0 #>          X43_Y-74..Macrophage X42_Y-74..Macrophage X47_Y-75..Macrophage #> PDK4                        0             4.940848            0.4148097 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             0.000000            0.0000000 #> GZMB                        0             0.000000            0.4514337 #> TSC2                        0             0.000000            0.0000000 #>          X43_Y-75..Macrophage X45_Y-75..Macrophage X46_Y-75..Macrophage #> PDK4                        0             2.181905             0.000000 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             0.000000             0.000000 #> GZMB                        0             1.319280             2.234142 #> TSC2                        0             0.000000             0.000000 #>          X42_Y-76..Macrophage X47_Y-76..Macrophage X44_Y-76..Macrophage #> PDK4                 4.233436            0.7703822                    0 #> TNFRSF17             0.000000            0.0000000                    0 #> ICAM3                0.000000            0.0000000                    0 #> FAP                  0.000000            0.0000000                    0 #> GZMB                 0.000000            0.0000000                    0 #> TSC2                 0.000000            0.0000000                    0 #>          X43_Y-77..Macrophage X47_Y-77..Macrophage X45_Y-78..Macrophage #> PDK4                        0             1.077327              1.76163 #> TNFRSF17                    0             0.000000              0.00000 #> ICAM3                       0             0.000000              0.00000 #> FAP                         0             0.000000              0.00000 #> GZMB                        0             0.000000              0.00000 #> TSC2                        0             0.000000              0.00000 #>          X47_Y-78..Macrophage X44_Y-78..Macrophage X46_Y-79..Macrophage #> PDK4                  0.00000                    0               0.4928 #> TNFRSF17              0.00000                    0               0.0000 #> ICAM3                 0.00000                    0               0.0000 #> FAP                   0.00000                    0               0.0000 #> GZMB                  1.08498                    0               0.0000 #> TSC2                  0.00000                    0               0.0000 #>          X47_Y-79..Macrophage X48_Y-72..Macrophage X47_Y-73..Macrophage #> PDK4                   0.4312            1.9229972                    0 #> TNFRSF17               0.0000            0.0000000                    0 #> ICAM3                  0.0000            0.0000000                    0 #> FAP                    0.0000            0.0000000                    0 #> GZMB                   0.0000            0.7472766                    0 #> TSC2                   0.0000            0.0000000                    0 #>          X46_Y-76..Macrophage X43_Y-78..Macrophage X74_Y-79..Macrophage #> PDK4                 1.925955             1.985932             4.494189 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  0.000000             0.000000             0.000000 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             4.494189 #>          X75_Y-80..Macrophage X76_Y-80..Macrophage X74_Y-80..Macrophage #> PDK4                 1.430077             1.003409             4.649974 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  0.000000             0.000000             0.000000 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             2.247095 #>          X76_Y-81..Macrophage X74_Y-81..Macrophage X78_Y-81..Macrophage #> PDK4                0.6689396                    0            0.7161321 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.0000000                    0            0.0000000 #> GZMB                0.0000000                    0            0.0000000 #> TSC2                0.0000000                    0            0.0000000 #>          X77_Y-81..Macrophage X73_Y-82..Macrophage X77_Y-82..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X78_Y-82..Macrophage X76_Y-82..Macrophage X76_Y-83..Macrophage #> PDK4                 1.291222             4.887178             5.273895 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  0.000000             0.000000             0.000000 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             0.000000 #>          X74_Y-83..Macrophage X75_Y-84..Macrophage X77_Y-84..Macrophage #> PDK4                        0             1.612094                    0 #> TNFRSF17                    0             0.000000                    0 #> ICAM3                       0             0.000000                    0 #> FAP                         0             0.000000                    0 #> GZMB                        0             0.000000                    0 #> TSC2                        0             1.612094                    0 #>          X74_Y-84..Macrophage X73_Y-85..Macrophage X77_Y-80..Macrophage #> PDK4                  1.20907                    0                    0 #> TNFRSF17              0.00000                    0                    0 #> ICAM3                 0.00000                    0                    0 #> FAP                   0.00000                    0                    0 #> GZMB                  0.00000                    0                    0 #> TSC2                  1.20907                    0                    0 #>          X75_Y-81..Macrophage X73_Y-81..Macrophage X78_Y-83..Macrophage #> PDK4                 2.145116                    0            0.9207134 #> TNFRSF17             0.000000                    0            0.0000000 #> ICAM3                0.000000                    0            0.0000000 #> FAP                  0.000000                    0            0.0000000 #> GZMB                 0.000000                    0            0.0000000 #> TSC2                 0.000000                    0            0.0000000 #>          X77_Y-85..Macrophage X74_Y-66..Macrophage X74_Y-67..Macrophage #> PDK4                        0            0.5188800            0.5299539 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.0000000            0.0000000 #> GZMB                        0            0.5188800            0.0000000 #> TSC2                        0            0.3800901            0.0000000 #>          X75_Y-67..Macrophage X77_Y-67..Macrophage X75_Y-68..Macrophage #> PDK4                1.0911639                    0            1.2825478 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.0000000                    0            0.0000000 #> GZMB                0.3338055                    0            0.3081281 #> TSC2                0.3611003                    0            0.5862004 #>          X77_Y-68..Macrophage X76_Y-68..Macrophage X78_Y-68..Macrophage #> PDK4                0.4940712             1.564201                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 0.0000000             0.000000                    0 #> GZMB                0.0000000             0.000000                    0 #> TSC2                0.0000000             0.000000                    0 #>          X74_Y-68..Macrophage X77_Y-69..Macrophage X78_Y-69..Macrophage #> PDK4                0.6944859                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 0.0000000                    0                    0 #> GZMB                0.0000000                    0                    0 #> TSC2                0.0000000                    0                    0 #>          X75_Y-69..Macrophage X76_Y-69..Macrophage X73_Y-69..Macrophage #> PDK4                0.5965257             1.226915            0.0000000 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.0000000             0.000000            0.0000000 #> GZMB                0.0000000             0.000000            0.4970848 #> TSC2                0.0000000             0.000000            0.0000000 #>          X74_Y-69..Macrophage X77_Y-70..Macrophage X76_Y-70..Macrophage #> PDK4                0.3240934                    0            0.7564669 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.0000000                    0            0.0000000 #> GZMB                0.2319729                    0            0.0000000 #> TSC2                0.0000000                    0            0.0000000 #>          X74_Y-70..Macrophage X78_Y-71..Macrophage X77_Y-71..Macrophage #> PDK4                        0             2.133611                    0 #> TNFRSF17                    0             0.000000                    0 #> ICAM3                       0             0.000000                    0 #> FAP                         0             0.000000                    0 #> GZMB                        0             0.000000                    0 #> TSC2                        0             0.000000                    0 #>          X74_Y-71..Macrophage X77_Y-72..Macrophage X74_Y-72..Macrophage #> PDK4                        0            0.6891369                    0 #> TNFRSF17                    0            0.0000000                    0 #> ICAM3                       0            0.0000000                    0 #> FAP                         0            0.0000000                    0 #> GZMB                        0            0.0000000                    0 #> TSC2                        0            0.0000000                    0 #>          X76_Y-73..Macrophage X76_Y-67..Macrophage X60_Y-67..Macrophage #> PDK4                  0.00000            0.6339231             1.573619 #> TNFRSF17              0.00000            0.0000000             0.000000 #> ICAM3                 0.00000            0.0000000             0.000000 #> FAP                   0.00000            0.0000000             0.000000 #> GZMB                  1.09251            0.0000000             0.000000 #> TSC2                  0.00000            0.0000000             0.000000 #>          X57_Y-67..Macrophage X57_Y-68..Macrophage X58_Y-69..Macrophage #> PDK4                 1.243104             1.243104             1.084434 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  0.000000             0.000000             0.000000 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             0.000000 #>          X57_Y-69..Macrophage X59_Y-70..Macrophage X55_Y-66..Macrophage #> PDK4                 1.675797             2.579847              0.00000 #> TNFRSF17             0.000000             0.000000              0.00000 #> ICAM3                0.000000             0.000000              0.00000 #> FAP                  0.000000             0.000000              0.00000 #> GZMB                 0.000000             0.000000              0.00000 #> TSC2                 0.000000             0.000000              1.09251 #>          X56_Y-67..Macrophage X59_Y-68..Macrophage X58_Y-72..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X47_Y-80..Macrophage X45_Y-80..Macrophage X43_Y-80..Macrophage #> PDK4                0.6487569                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 0.0000000                    0                    0 #> GZMB                0.0000000                    0                    0 #> TSC2                0.6487569                    0                    0 #>          X44_Y-81..Macrophage X46_Y-81..Macrophage X45_Y-81..Macrophage #> PDK4                 0.734317             1.268668             2.057258 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  0.000000             0.000000             0.000000 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             0.000000 #>          X47_Y-81..Macrophage X46_Y-82..Macrophage X45_Y-82..Macrophage #> PDK4                 1.171749            0.4331415            0.9817677 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.000000            0.0000000            0.0000000 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X44_Y-82..Macrophage X42_Y-82..Macrophage X47_Y-82..Macrophage #> PDK4                0.8081269               0.0000            0.4764556 #> TNFRSF17            0.0000000               0.0000            0.0000000 #> ICAM3               0.0000000               0.0000            0.0000000 #> FAP                 0.0000000               0.0000            0.0000000 #> GZMB                0.0000000               4.5208            0.0000000 #> TSC2                0.0000000               0.0000            0.0000000 #>          X46_Y-83..Macrophage X45_Y-83..Macrophage X44_Y-83..Macrophage #> PDK4                0.4374156             0.899262                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 0.0000000             0.000000                    0 #> GZMB                0.0000000             0.000000                    0 #> TSC2                0.0000000             0.000000                    0 #>          X44_Y-84..Macrophage X43_Y-84..Macrophage X45_Y-84..Macrophage #> PDK4                0.7999609            1.5193130                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.0000000            0.0000000                    0 #> GZMB                0.0000000            0.5362088                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X45_Y-85..Macrophage X44_Y-85..Macrophage X48_Y-85..Macrophage #> PDK4                0.4733172                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 0.0000000                    0                    0 #> GZMB                0.0000000                    0                    0 #> TSC2                0.4733172                    0                    0 #>          X46_Y-80..Macrophage X44_Y-80..Macrophage X43_Y-81..Macrophage #> PDK4                0.5165802                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 0.0000000                    0                    0 #> GZMB                0.0000000                    0                    0 #> TSC2                0.0000000                    0                    0 #>          X43_Y-82..Macrophage X43_Y-83..Macrophage X47_Y-83..Macrophage #> PDK4                0.6926802            0.9455837             1.312247 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.0000000            0.0000000             0.000000 #> GZMB                0.0000000            1.0724177             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X51_Y-92..Macrophage X49_Y-92..Macrophage X52_Y-92..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X50_Y-93..Macrophage X53_Y-93..Macrophage X51_Y-94..Macrophage #> PDK4                0.0000000            0.7789529                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.0000000            0.0000000                    0 #> GZMB                0.0000000            0.0000000                    0 #> TSC2                0.9652436            0.0000000                    0 #>          X49_Y-94..Macrophage X49_Y-96..Macrophage X52_Y-96..Macrophage #> PDK4                        0             1.107601                    0 #> TNFRSF17                    0             0.000000                    0 #> ICAM3                       0             0.000000                    0 #> FAP                         0             0.000000                    0 #> GZMB                        0             0.000000                    0 #> TSC2                        0             0.000000                    0 #>          X51_Y-97..Macrophage X54_Y-97..Macrophage X51_Y-91..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X50_Y-92..Macrophage X55_Y-93..Macrophage X54_Y-94..Macrophage #> PDK4                        0             1.231419             1.092757 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             0.000000             0.000000 #> GZMB                        0             0.000000             2.297221 #> TSC2                        0             0.000000             0.000000 #>          X53_Y-96..Macrophage X53_Y-97..Macrophage X69_Y-79..Macrophage #> PDK4                 1.735247             3.470495                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  0.000000             0.000000                    0 #> GZMB                 0.000000             0.000000                    0 #> TSC2                 0.000000             0.000000                    0 #>          X71_Y-80..Macrophage X68_Y-80..Macrophage X70_Y-81..Macrophage #> PDK4                0.8298395             3.545876                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 0.0000000             0.000000                    0 #> GZMB                0.3961696             0.000000                    0 #> TSC2                0.3961696             0.000000                    0 #>          X72_Y-82..Macrophage X71_Y-82..Macrophage X70_Y-82..Macrophage #> PDK4                        0            0.5563994            0.3709329 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.0000000            0.0000000 #> GZMB                        0            0.6195804            0.4130536 #> TSC2                        0            0.5563994            0.3709329 #>          X68_Y-83..Macrophage X71_Y-83..Macrophage X70_Y-83..Macrophage #> PDK4                        0             0.000000             1.238055 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             0.000000             0.000000 #> GZMB                        0             2.137791             0.000000 #> TSC2                        0             0.000000             0.000000 #>          X71_Y-84..Macrophage X68_Y-84..Macrophage X69_Y-84..Macrophage #> PDK4                 0.000000            1.2572428             1.898214 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  0.000000            0.0000000             0.000000 #> GZMB                 1.425194            0.2679326             1.123704 #> TSC2                 0.000000            0.0000000             0.000000 #>          X72_Y-84..Macrophage X67_Y-84..Macrophage X66_Y-84..Macrophage #> PDK4                 0.000000            1.1099815            0.6286768 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.000000            0.0000000            0.0000000 #> GZMB                 1.387668            0.5199874            0.2430336 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X68_Y-85..Macrophage X67_Y-85..Macrophage X70_Y-85..Macrophage #> PDK4                0.9548799             1.540507             1.640062 #> TNFRSF17            0.0000000             0.000000             0.000000 #> ICAM3               0.0000000             0.000000             0.000000 #> FAP                 0.0000000             0.000000             0.000000 #> GZMB                0.2679326             0.000000             0.000000 #> TSC2                0.0000000             0.000000             0.000000 #>          X71_Y-81..Macrophage X72_Y-81..Macrophage X70_Y-84..Macrophage #> PDK4                 0.000000                    0             2.138244 #> TNFRSF17             0.000000                    0             0.000000 #> ICAM3                0.000000                    0             0.000000 #> FAP                  0.000000                    0             0.000000 #> GZMB                 1.980848                    0             0.000000 #> TSC2                 1.980848                    0             0.000000 #>          X72_Y-85..Macrophage X50_Y-67..Macrophage X52_Y-68..Macrophage #> PDK4                 0.000000            0.7197459            0.0000000 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.000000            0.0000000            0.0000000 #> GZMB                 2.775336            0.0000000            0.5466230 #> TSC2                 0.000000            0.6303891            0.6544827 #>          X51_Y-68..Macrophage X53_Y-68..Macrophage X50_Y-68..Macrophage #> PDK4                0.6991793            0.0000000             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.0000000            0.0000000             0.000000 #> GZMB                0.0000000            0.6719207             0.000000 #> TSC2                0.2643641            0.6719207             3.814873 #>          X51_Y-69..Macrophage X54_Y-69..Macrophage X50_Y-69..Macrophage #> PDK4                0.9089739                    0             2.532002 #> TNFRSF17            0.0000000                    0             0.000000 #> ICAM3               0.0000000                    0             0.000000 #> FAP                 0.0000000                    0             0.000000 #> GZMB                0.0000000                    0             0.000000 #> TSC2                0.0000000                    0             0.000000 #>          X52_Y-69..Macrophage X50_Y-70..Macrophage X51_Y-70..Macrophage #> PDK4                 1.605711            0.5450324             1.555727 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  0.000000            0.0000000             0.000000 #> GZMB                 0.000000            0.0000000             0.270124 #> TSC2                 0.000000            0.0000000             0.000000 #>          X52_Y-70..Macrophage X51_Y-71..Macrophage X52_Y-71..Macrophage #> PDK4                 2.264075            0.5947745            1.4654796 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.000000            0.0000000            0.0000000 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.4646853 #>          X53_Y-72..Macrophage X49_Y-69..Macrophage X53_Y-71..Macrophage #> PDK4                 1.631243             2.123871                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  0.000000             0.000000                    0 #> GZMB                 1.367679             0.000000                    0 #> TSC2                 0.000000             0.000000                    0 #>          X51_Y-72..Macrophage X66_Y-64..Macrophage X64_Y-64..Macrophage #> PDK4                 0.000000            0.0000000             1.249362 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  0.000000            0.0000000             0.000000 #> GZMB                 1.243104            0.0000000             0.000000 #> TSC2                 0.000000            0.6520692             0.000000 #>          X64_Y-65..Macrophage X61_Y-65..Macrophage X65_Y-65..Macrophage #> PDK4                 1.249362             1.391988                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  0.000000             0.000000                    0 #> GZMB                 0.000000             0.000000                    0 #> TSC2                 0.000000             0.000000                    0 #>          X61_Y-64..Macrophage X66_Y-65..Macrophage X55_Y-79..Macrophage #> PDK4                 1.391988            0.0000000                    0 #> TNFRSF17             0.000000            0.0000000                    0 #> ICAM3                0.000000            0.0000000                    0 #> FAP                  0.000000            0.0000000                    0 #> GZMB                 0.000000            0.0000000                    0 #> TSC2                 0.000000            0.4890519                    0 #>          X59_Y-79..Macrophage X57_Y-79..Macrophage X61_Y-79..Macrophage #> PDK4                 2.016249             1.904192                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  0.000000             0.000000                    0 #> GZMB                 0.000000             0.000000                    0 #> TSC2                 0.000000             0.000000                    0 #>          X57_Y-80..Macrophage X58_Y-80..Macrophage X55_Y-80..Macrophage #> PDK4                 2.705544                    0            0.8665309 #> TNFRSF17             0.000000                    0            0.0000000 #> ICAM3                0.000000                    0            0.0000000 #> FAP                  0.000000                    0            0.0000000 #> GZMB                 0.000000                    0            0.0000000 #> TSC2                 0.000000                    0            0.0000000 #>          X60_Y-80..Macrophage X59_Y-80..Macrophage X56_Y-80..Macrophage #> PDK4                        0                    0             1.904192 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X55_Y-81..Macrophage X59_Y-81..Macrophage X57_Y-81..Macrophage #> PDK4                        0            0.3096855             1.927192 #> TNFRSF17                    0            0.0000000             0.000000 #> ICAM3                       0            0.0000000             0.000000 #> FAP                         0            0.0000000             0.000000 #> GZMB                        0            0.0000000             0.000000 #> TSC2                        0            0.0000000             0.000000 #>          X58_Y-81..Macrophage X61_Y-81..Macrophage X58_Y-82..Macrophage #> PDK4                0.0000000                    0            0.0000000 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.0000000                    0            0.0000000 #> GZMB                0.6497364                    0            0.5685193 #> TSC2                0.0000000                    0            0.0000000 #>          X54_Y-82..Macrophage X59_Y-82..Macrophage X55_Y-82..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X57_Y-82..Macrophage X56_Y-82..Macrophage X56_Y-83..Macrophage #> PDK4                1.2137653            1.1549744            0.5256183 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            0.0000000            0.0000000 #> GZMB                0.9733472            0.5561984            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X55_Y-83..Macrophage X60_Y-83..Macrophage X57_Y-83..Macrophage #> PDK4                0.7119445                    0            0.6068826 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.0000000                    0            0.0000000 #> GZMB                0.0000000                    0            0.0000000 #> TSC2                0.0000000                    0            0.3122763 #>          X54_Y-84..Macrophage X57_Y-84..Macrophage X56_Y-84..Macrophage #> PDK4                0.7769025                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 0.0000000                    0                    0 #> GZMB                0.0000000                    0                    0 #> TSC2                0.0000000                    0                    0 #>          X58_Y-84..Macrophage X59_Y-84..Macrophage X57_Y-85..Macrophage #> PDK4                        0             2.219452                    0 #> TNFRSF17                    0             0.000000                    0 #> ICAM3                       0             0.000000                    0 #> FAP                         0             0.000000                    0 #> GZMB                        0             0.000000                    0 #> TSC2                        0             0.000000                    0 #>          X58_Y-85..Macrophage X60_Y-85..Macrophage X55_Y-85..Macrophage #> PDK4                 1.946694             0.782483              1.48217 #> TNFRSF17             0.000000             0.000000              0.00000 #> ICAM3                0.000000             0.000000              0.00000 #> FAP                  0.000000             0.000000              0.00000 #> GZMB                 0.000000             0.000000              0.00000 #> TSC2                 1.717478             0.000000              0.00000 #>          X54_Y-80..Macrophage X60_Y-81..Macrophage X58_Y-83..Macrophage #> PDK4                 1.090828            0.5806603                    0 #> TNFRSF17             0.000000            0.0000000                    0 #> ICAM3                0.000000            0.0000000                    0 #> FAP                  0.000000            0.0000000                    0 #> GZMB                 0.000000            0.0000000                    0 #> TSC2                 0.000000            0.0000000                    0 #>          X55_Y-84..Macrophage X56_Y-85..Macrophage X65_Y-80..Macrophage #> PDK4                 1.553805            0.9686831                    0 #> TNFRSF17             0.000000            0.0000000                    0 #> ICAM3                0.000000            0.0000000                    0 #> FAP                  0.000000            0.0000000                    0 #> GZMB                 0.000000            0.0000000                    0 #> TSC2                 0.000000            0.0000000                    0 #>          X66_Y-82..Macrophage X65_Y-82..Macrophage X63_Y-82..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X61_Y-82..Macrophage X66_Y-83..Macrophage X61_Y-83..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X64_Y-83..Macrophage X63_Y-83..Macrophage X62_Y-83..Macrophage #> PDK4                        0             0.653492            0.3713572 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             0.000000            0.0000000 #> GZMB                        0             0.000000            0.3795001 #> TSC2                        0             0.000000            0.0000000 #>          X63_Y-84..Macrophage X62_Y-84..Macrophage X61_Y-84..Macrophage #> PDK4                0.3805688            0.8965053               0.0000 #> TNFRSF17            0.0000000            0.0000000               0.0000 #> ICAM3               0.0000000            0.0000000               0.0000 #> FAP                 0.0000000            0.0000000               0.0000 #> GZMB                0.0000000            0.2919231               1.8975 #> TSC2                0.0000000            0.0000000               0.0000 #>          X65_Y-84..Macrophage X64_Y-84..Macrophage X65_Y-85..Macrophage #> PDK4                        0                    0            0.2815873 #> TNFRSF17                    0                    0            0.0000000 #> ICAM3                       0                    0            0.0000000 #> FAP                         0                    0            0.0000000 #> GZMB                        0                    0            0.0000000 #> TSC2                        0                    0            0.0000000 #>          X63_Y-85..Macrophage X66_Y-85..Macrophage X64_Y-85..Macrophage #> PDK4                0.4138814            1.3142893            0.4598682 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            0.0000000            0.0000000 #> GZMB                0.0000000            0.2971418            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X63_Y-81..Macrophage X62_Y-85..Macrophage X36_Y-91..Macrophage #> PDK4                 4.378773              1.16648            0.6801428 #> TNFRSF17             0.000000              0.00000            0.0000000 #> ICAM3                0.000000              0.00000            0.0000000 #> FAP                  0.000000              0.00000            0.0000000 #> GZMB                 0.000000              0.00000            0.0000000 #> TSC2                 0.000000              0.00000            0.8482456 #>          X35_Y-91..Macrophage X32_Y-91..Macrophage X35_Y-92..Macrophage #> PDK4                 0.845326                    0             1.615194 #> TNFRSF17             0.000000                    0             0.000000 #> ICAM3                0.000000                    0             0.000000 #> FAP                  0.000000                    0             0.000000 #> GZMB                 0.000000                    0             0.000000 #> TSC2                 0.000000                    0             0.000000 #>          X34_Y-92..Macrophage X32_Y-93..Macrophage X30_Y-93..Macrophage #> PDK4                  1.02649                    0             1.832073 #> TNFRSF17              0.00000                    0             0.000000 #> ICAM3                 0.00000                    0             0.000000 #> FAP                   0.00000                    0             0.000000 #> GZMB                  0.00000                    0             0.000000 #> TSC2                  0.00000                    0             0.000000 #>          X35_Y-93..Macrophage X31_Y-93..Macrophage X33_Y-93..Macrophage #> PDK4                0.9123604                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 0.0000000                    0                    0 #> GZMB                0.0000000                    0                    0 #> TSC2                0.0000000                    0                    0 #>          X34_Y-93..Macrophage X31_Y-94..Macrophage X34_Y-94..Macrophage #> PDK4                 1.514592             1.062001             1.298222 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  0.000000             0.000000             0.000000 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             0.000000 #>          X30_Y-94..Macrophage X35_Y-94..Macrophage X32_Y-94..Macrophage #> PDK4                 3.956074             3.628044                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  0.000000             0.000000                    0 #> GZMB                 0.000000             0.000000                    0 #> TSC2                 0.000000             0.000000                    0 #>          X31_Y-95..Macrophage X32_Y-95..Macrophage X30_Y-95..Macrophage #> PDK4                        0             3.181991                    0 #> TNFRSF17                    0             0.000000                    0 #> ICAM3                       0             0.000000                    0 #> FAP                         0             0.000000                    0 #> GZMB                        0             0.000000                    0 #> TSC2                        0             0.000000                    0 #>          X33_Y-95..Macrophage X31_Y-96..Macrophage X33_Y-96..Macrophage #> PDK4                 2.283413             2.513632             1.522275 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  0.000000             0.000000             0.000000 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             0.000000 #>          X34_Y-96..Macrophage X36_Y-96..Macrophage X30_Y-97..Macrophage #> PDK4                        0            0.9098643                    0 #> TNFRSF17                    0            0.0000000                    0 #> ICAM3                       0            0.0000000                    0 #> FAP                         0            0.0000000                    0 #> GZMB                        0            0.0000000                    0 #> TSC2                        0            0.0000000                    0 #>          X35_Y-97..Macrophage X31_Y-97..Macrophage X34_Y-91..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X34_Y-95..Macrophage X35_Y-95..Macrophage X33_Y-97..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X43_Y-85..Macrophage X45_Y-86..Macrophage X44_Y-86..Macrophage #> PDK4                 2.107297            0.6310897                    0 #> TNFRSF17             0.000000            0.0000000                    0 #> ICAM3                0.000000            0.0000000                    0 #> FAP                  0.000000            0.0000000                    0 #> GZMB                 0.000000            0.0000000                    0 #> TSC2                 0.000000            0.6310897                    0 #>          X47_Y-86..Macrophage X47_Y-87..Macrophage X46_Y-87..Macrophage #> PDK4                 1.173358             1.197144            1.3121289 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  0.000000             0.000000            0.0000000 #> GZMB                 0.000000             0.000000            0.3213693 #> TSC2                 0.000000             0.000000            0.0000000 #>          X42_Y-87..Macrophage X45_Y-87..Macrophage X45_Y-88..Macrophage #> PDK4                        0            0.3007899            0.2455913 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.0000000            0.0000000 #> GZMB                        0            0.2570955            0.0000000 #> TSC2                        0            0.0000000            0.0000000 #>          X46_Y-88..Macrophage X47_Y-88..Macrophage X48_Y-88..Macrophage #> PDK4                 1.173258            1.3771630             1.449386 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  0.000000            0.0000000             0.000000 #> GZMB                 0.000000            0.6360818             0.000000 #> TSC2                 0.000000            0.6360818             0.000000 #>          X44_Y-88..Macrophage X45_Y-89..Macrophage X46_Y-89..Macrophage #> PDK4                 1.546716            0.4720003            0.8412262 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.000000            0.0000000            0.0000000 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X47_Y-89..Macrophage X44_Y-89..Macrophage X42_Y-89..Macrophage #> PDK4                0.6839841                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 0.0000000                    0                    0 #> GZMB                0.5452129                    0                    0 #> TSC2                0.5452129                    0                    0 #>          X45_Y-90..Macrophage X44_Y-90..Macrophage X47_Y-90..Macrophage #> PDK4                        0                    0            1.7925858 #> TNFRSF17                    0                    0            0.0000000 #> ICAM3                       0                    0            0.0000000 #> FAP                         0                    0            0.0000000 #> GZMB                        0                    0            0.3052174 #> TSC2                        0                    0            0.0000000 #>          X43_Y-90..Macrophage X46_Y-90..Macrophage X42_Y-90..Macrophage #> PDK4                0.0000000            1.6208795            0.6835998 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            0.0000000            0.0000000 #> GZMB                0.0000000            0.3391304            0.3899701 #> TSC2                0.6757949            0.0000000            0.4300513 #>          X46_Y-91..Macrophage X45_Y-91..Macrophage X48_Y-86..Macrophage #> PDK4                        0             1.343260            0.8800182 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             0.000000            0.0000000 #> GZMB                        0             1.118085            0.0000000 #> TSC2                        0             0.000000            0.0000000 #>          X48_Y-89..Macrophage X49_Y-80..Macrophage X50_Y-80..Macrophage #> PDK4                 1.196972             0.804527                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  0.000000             0.000000                    0 #> GZMB                 0.000000             0.000000                    0 #> TSC2                 0.000000             0.000000                    0 #>          X51_Y-80..Macrophage X52_Y-80..Macrophage X48_Y-80..Macrophage #> PDK4                 1.286015             1.560655                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  0.000000             0.000000                    0 #> GZMB                 0.000000             0.000000                    0 #> TSC2                 0.000000             0.000000                    0 #>          X53_Y-81..Macrophage X50_Y-81..Macrophage X52_Y-81..Macrophage #> PDK4                0.8507498                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 0.0000000                    0                    0 #> GZMB                0.0000000                    0                    0 #> TSC2                0.0000000                    0                    0 #>          X54_Y-81..Macrophage X51_Y-81..Macrophage X53_Y-82..Macrophage #> PDK4                        0                    0            0.7165094 #> TNFRSF17                    0                    0            0.0000000 #> ICAM3                       0                    0            0.0000000 #> FAP                         0                    0            0.0000000 #> GZMB                        0                    0            0.0000000 #> TSC2                        0                    0            0.0000000 #>          X51_Y-82..Macrophage X52_Y-82..Macrophage X54_Y-83..Macrophage #> PDK4                0.5127672                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 0.0000000                    0                    0 #> GZMB                0.0000000                    0                    0 #> TSC2                0.0000000                    0                    0 #>          X49_Y-83..Macrophage X52_Y-83..Macrophage X51_Y-83..Macrophage #> PDK4                        0            0.6397457             1.061121 #> TNFRSF17                    0            0.0000000             0.000000 #> ICAM3                       0            0.0000000             0.000000 #> FAP                         0            0.0000000             0.000000 #> GZMB                        0            0.0000000             0.574910 #> TSC2                        0            0.0000000             0.000000 #>          X51_Y-84..Macrophage X53_Y-84..Macrophage X52_Y-84..Macrophage #> PDK4                0.3021049             1.262179                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 0.0000000             0.000000                    0 #> GZMB                0.3021049             0.000000                    0 #> TSC2                0.0000000             1.262179                    0 #>          X52_Y-85..Macrophage X51_Y-85..Macrophage X53_Y-80..Macrophage #> PDK4                        0                    0             1.648775 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X49_Y-85..Macrophage X69_Y-92..Macrophage X67_Y-93..Macrophage #> PDK4                        0             2.247095                    0 #> TNFRSF17                    0             0.000000                    0 #> ICAM3                       0             0.000000                    0 #> FAP                         0             0.000000                    0 #> GZMB                        0             0.000000                    0 #> TSC2                        0             0.000000                    0 #>          X70_Y-93..Macrophage X66_Y-94..Macrophage X68_Y-96..Macrophage #> PDK4                        0                    0              0.00000 #> TNFRSF17                    0                    0              0.00000 #> ICAM3                       0                    0              0.00000 #> FAP                         0                    0              0.00000 #> GZMB                        0                    0              2.25149 #> TSC2                        0                    0              0.00000 #>          X71_Y-92..Macrophage X69_Y-93..Macrophage X69_Y-96..Macrophage #> PDK4                        0                    0             0.000000 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             1.500993 #> TSC2                        0                    0             0.000000 #>          X24_Y-65..Macrophage X26_Y-65..Macrophage X23_Y-66..Macrophage #> PDK4                 2.170562                    0                    0 #> TNFRSF17             0.000000                    0                    0 #> ICAM3                0.000000                    0                    0 #> FAP                  0.000000                    0                    0 #> GZMB                 0.000000                    0                    0 #> TSC2                 0.000000                    0                    0 #>          X28_Y-67..Macrophage X73_Y-92..Macrophage X78_Y-92..Macrophage #> PDK4                 2.127412                    0                    0 #> TNFRSF17             0.000000                    0                    0 #> ICAM3                0.000000                    0                    0 #> FAP                  0.000000                    0                    0 #> GZMB                 0.000000                    0                    0 #> TSC2                 0.000000                    0                    0 #>          X75_Y-92..Macrophage X78_Y-93..Macrophage X77_Y-93..Macrophage #> PDK4                  4.44265             4.443386             2.009494 #> TNFRSF17              0.00000             0.000000             0.000000 #> ICAM3                 0.00000             0.000000             0.000000 #> FAP                   0.00000             0.000000             0.000000 #> GZMB                  0.00000             0.000000             0.000000 #> TSC2                  0.00000             0.000000             0.000000 #>          X79_Y-93..Macrophage X74_Y-93..Macrophage X78_Y-94..Macrophage #> PDK4                 4.163422                    0                    0 #> TNFRSF17             0.000000                    0                    0 #> ICAM3                0.000000                    0                    0 #> FAP                  0.000000                    0                    0 #> GZMB                 0.000000                    0                    0 #> TSC2                 0.000000                    0                    0 #>          X77_Y-96..Macrophage X76_Y-96..Macrophage X76_Y-97..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X74_Y-91..Macrophage X76_Y-93..Macrophage X74_Y-94..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X75_Y-94..Macrophage X45_Y-67..Macrophage X47_Y-67..Macrophage #> PDK4                        0             3.397916            1.1369178 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             0.000000            0.0000000 #> GZMB                        0             0.000000            0.0000000 #> TSC2                        0             0.000000            0.5386708 #>          X47_Y-68..Macrophage X43_Y-68..Macrophage X46_Y-68..Macrophage #> PDK4                 4.005306             1.427534            0.4765399 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  0.000000             0.000000            0.0000000 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X45_Y-69..Macrophage X44_Y-69..Macrophage X47_Y-69..Macrophage #> PDK4                 1.385737                    0             3.183312 #> TNFRSF17             0.000000                    0             0.000000 #> ICAM3                0.000000                    0             0.000000 #> FAP                  0.000000                    0             0.000000 #> GZMB                 0.000000                    0             1.661037 #> TSC2                 0.000000                    0             0.000000 #>          X43_Y-70..Macrophage X45_Y-70..Macrophage X42_Y-70..Macrophage #> PDK4                        0             3.180686             3.569047 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             0.000000             0.000000 #> GZMB                        0             0.000000             0.000000 #> TSC2                        0             0.000000             0.000000 #>          X44_Y-70..Macrophage X44_Y-71..Macrophage X47_Y-71..Macrophage #> PDK4                 2.343499                    0             2.343499 #> TNFRSF17             0.000000                    0             0.000000 #> ICAM3                0.000000                    0             0.000000 #> FAP                  0.000000                    0             0.000000 #> GZMB                 0.000000                    0             0.000000 #> TSC2                 0.000000                    0             0.000000 #>          X43_Y-71..Macrophage X48_Y-71..Macrophage X44_Y-72..Macrophage #> PDK4                  2.19329             3.513731                    0 #> TNFRSF17              0.00000             0.000000                    0 #> ICAM3                 0.00000             0.000000                    0 #> FAP                   0.00000             0.000000                    0 #> GZMB                  0.00000             0.000000                    0 #> TSC2                  0.00000             0.000000                    0 #>          X47_Y-72..Macrophage X43_Y-72..Macrophage X48_Y-67..Macrophage #> PDK4                        0             3.883364                    0 #> TNFRSF17                    0             0.000000                    0 #> ICAM3                       0             0.000000                    0 #> FAP                         0             0.000000                    0 #> GZMB                        0             0.000000                    0 #> TSC2                        0             0.000000                    0 #>          X48_Y-70..Macrophage X74_Y-65..Macrophage X73_Y-65..Macrophage #> PDK4                        0            0.0000000            0.7872996 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.0000000            0.0000000 #> GZMB                        0            0.5356225            0.0000000 #> TSC2                        0            0.0000000            0.3668385 #>          X78_Y-65..Macrophage X72_Y-66..Macrophage X23_Y-91..Macrophage #> PDK4                        0            1.1994749             4.071364 #> TNFRSF17                    0            0.0000000             0.000000 #> ICAM3                       0            0.0000000             0.000000 #> FAP                         0            0.0000000             0.000000 #> GZMB                        0            0.0000000             0.000000 #> TSC2                        0            0.4039133             0.000000 #>          X22_Y-93..Macrophage X22_Y-94..Macrophage X22_Y-95..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X23_Y-96..Macrophage X23_Y-97..Macrophage X23_Y-85..Macrophage #> PDK4                        0             4.621654             2.120614 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             0.000000             0.000000 #> GZMB                        0             1.278012             0.000000 #> TSC2                        0             0.000000             0.000000 #>          X25_Y-86..Macrophage X24_Y-86..Macrophage X27_Y-88..Macrophage #> PDK4                        0              2.72096                    0 #> TNFRSF17                    0              0.00000                    0 #> ICAM3                       0              0.00000                    0 #> FAP                         0              0.00000                    0 #> GZMB                        0              0.00000                    0 #> TSC2                        0              0.00000                    0 #>          X27_Y-89..Macrophage X24_Y-89..Macrophage X24_Y-90..Macrophage #> PDK4                 1.651578                    0                    0 #> TNFRSF17             0.000000                    0                    0 #> ICAM3                0.000000                    0                    0 #> FAP                  0.000000                    0                    0 #> GZMB                 0.000000                    0                    0 #> TSC2                 0.000000                    0                    0 #>          X24_Y-91..Macrophage X24_Y-87..Macrophage X27_Y-90..Macrophage #> PDK4                        0              2.72096                    0 #> TNFRSF17                    0              0.00000                    0 #> ICAM3                       0              0.00000                    0 #> FAP                         0              0.00000                    0 #> GZMB                        0              0.00000                    0 #> TSC2                        0              0.00000                    0 #>          X27_Y-91..Macrophage X35_Y-85..Macrophage X34_Y-85..Macrophage #> PDK4                        0             1.891167             3.782335 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             0.000000             0.000000 #> GZMB                        0             0.000000             0.000000 #> TSC2                        0             0.000000             0.000000 #>          X33_Y-86..Macrophage X35_Y-86..Macrophage X35_Y-87..Macrophage #> PDK4                        0             1.786649               1.8975 #> TNFRSF17                    0             0.000000               0.0000 #> ICAM3                       0             0.000000               0.0000 #> FAP                         0             0.000000               0.0000 #> GZMB                        0             0.000000               0.0000 #> TSC2                        0             0.000000               0.0000 #>          X36_Y-88..Macrophage X36_Y-89..Macrophage X35_Y-90..Macrophage #> PDK4                 2.239189            0.8544196                    0 #> TNFRSF17             0.000000            0.0000000                    0 #> ICAM3                0.000000            0.0000000                    0 #> FAP                  0.000000            0.0000000                    0 #> GZMB                 0.000000            0.0000000                    0 #> TSC2                 0.000000            0.0000000                    0 #>          X33_Y-87..Macrophage X33_Y-88..Macrophage X33_Y-89..Macrophage #> PDK4                        0                    0              4.12076 #> TNFRSF17                    0                    0              0.00000 #> ICAM3                       0                    0              0.00000 #> FAP                         0                    0              0.00000 #> GZMB                        0                    0              0.00000 #> TSC2                        0                    0              0.00000 #>          X34_Y-90..Macrophage X41_Y-86..Macrophage X38_Y-86..Macrophage #> PDK4                        0                    0             0.000000 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             3.631375 #> TSC2                        0                    0             0.000000 #>          X36_Y-87..Macrophage X40_Y-88..Macrophage X41_Y-89..Macrophage #> PDK4                  3.29989                    0             1.781184 #> TNFRSF17              0.00000                    0             0.000000 #> ICAM3                 0.00000                    0             0.000000 #> FAP                   0.00000                    0             0.000000 #> GZMB                  0.00000                    0             0.000000 #> TSC2                  0.00000                    0             0.000000 #>          X37_Y-89..Macrophage X38_Y-89..Macrophage X36_Y-90..Macrophage #> PDK4                        0                    0             1.020861 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X38_Y-91..Macrophage X37_Y-91..Macrophage X41_Y-90..Macrophage #> PDK4                        0             1.239161                    0 #> TNFRSF17                    0             0.000000                    0 #> ICAM3                       0             0.000000                    0 #> FAP                         0             0.000000                    0 #> GZMB                        0             0.000000                    0 #> TSC2                        0             1.413743                    0 #>          X39_Y-90..Macrophage X34_Y-97..Macrophage X34_Y-98..Macrophage #> PDK4                        0                    0             2.817592 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X30_Y-98..Macrophage X32_Y-98..Macrophage X34_Y-99..Macrophage #> PDK4                        0                    0             1.244429 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X32_Y-99..Macrophage X35_Y-99..Macrophage X31_Y-99..Macrophage #> PDK4                 1.677227                    0                    0 #> TNFRSF17             0.000000                    0                    0 #> ICAM3                0.000000                    0                    0 #> FAP                  0.000000                    0                    0 #> GZMB                 0.000000                    0                    0 #> TSC2                 0.000000                    0                    0 #>          X33_Y-99..Macrophage X33_Y-100..Macrophage X32_Y-100..Macrophage #> PDK4                  2.60906               2.60906              4.144908 #> TNFRSF17              0.00000               0.00000              0.000000 #> ICAM3                 0.00000               0.00000              0.000000 #> FAP                   0.00000               0.00000              0.000000 #> GZMB                  0.00000               0.00000              0.000000 #> TSC2                  0.00000               0.00000              0.000000 #>          X35_Y-100..Macrophage X34_Y-100..Macrophage X31_Y-101..Macrophage #> PDK4                  2.005043                     0              3.059201 #> TNFRSF17              0.000000                     0              0.000000 #> ICAM3                 0.000000                     0              0.000000 #> FAP                   0.000000                     0              0.000000 #> GZMB                  0.000000                     0              0.000000 #> TSC2                  0.000000                     0              0.000000 #>          X32_Y-101..Macrophage X30_Y-102..Macrophage X32_Y-103..Macrophage #> PDK4                         0              1.869855              1.476806 #> TNFRSF17                     0              0.000000              0.000000 #> ICAM3                        0              0.000000              0.000000 #> FAP                          0              0.000000              0.000000 #> GZMB                         0              0.000000              0.000000 #> TSC2                         0              0.000000              0.000000 #>          X31_Y-103..Macrophage X30_Y-103..Macrophage X33_Y-103..Macrophage #> PDK4                 0.7974152              1.139165             0.8027275 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.0000000              0.000000             0.0000000 #> GZMB                 0.0000000              0.000000             0.0000000 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X34_Y-103..Macrophage X29_Y-103..Macrophage X31_Y-100..Macrophage #> PDK4                         0                     0                     0 #> TNFRSF17                     0                     0                     0 #> ICAM3                        0                     0                     0 #> FAP                          0                     0                     0 #> GZMB                         0                     0                     0 #> TSC2                         0                     0                     0 #>          X30_Y-101..Macrophage X22_Y-85..Macrophage X23_Y-86..Macrophage #> PDK4                  3.302477                    0             1.413743 #> TNFRSF17              0.000000                    0             0.000000 #> ICAM3                 0.000000                    0             0.000000 #> FAP                   0.000000                    0             0.000000 #> GZMB                  0.000000                    0             0.000000 #> TSC2                  0.000000                    0             0.000000 #>          X22_Y-86..Macrophage X21_Y-87..Macrophage X22_Y-88..Macrophage #> PDK4                        0             1.963114             1.963114 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             0.000000             0.000000 #> GZMB                        0             0.000000             0.000000 #> TSC2                        0             0.000000             0.000000 #>          X24_Y-88..Macrophage X23_Y-64..Macrophage X23_Y-65..Macrophage #> PDK4                 3.874733                    0                    0 #> TNFRSF17             0.000000                    0                    0 #> ICAM3                0.000000                    0                    0 #> FAP                  0.000000                    0                    0 #> GZMB                 0.000000                    0                    0 #> TSC2                 0.000000                    0                    0 #>          X22_Y-98..Macrophage X23_Y-98..Macrophage X22_Y-99..Macrophage #> PDK4                        0                    0             0.000000 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             2.104024 #>          X23_Y-99..Macrophage X23_Y-100..Macrophage X23_Y-101..Macrophage #> PDK4                        0              3.444907               3.52326 #> TNFRSF17                    0              0.000000               0.00000 #> ICAM3                       0              0.000000               0.00000 #> FAP                         0              0.000000               0.00000 #> GZMB                        0              0.000000               0.00000 #> TSC2                        0              0.000000               0.00000 #>          X22_Y-101..Macrophage X21_Y-101..Macrophage X23_Y-103..Macrophage #> PDK4                  4.311194                     0              1.588185 #> TNFRSF17              0.000000                     0              0.000000 #> ICAM3                 0.000000                     0              0.000000 #> FAP                   0.000000                     0              0.000000 #> GZMB                  0.000000                     0              0.000000 #> TSC2                  0.000000                     0              0.000000 #>          X25_Y-97..Macrophage X27_Y-98..Macrophage X26_Y-98..Macrophage #> PDK4                        0             1.946824             2.400924 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             0.000000             0.000000 #> GZMB                        0             0.000000             0.000000 #> TSC2                        0             0.000000             0.000000 #>          X24_Y-98..Macrophage X25_Y-99..Macrophage X27_Y-99..Macrophage #> PDK4                 4.426577                    0             4.091399 #> TNFRSF17             0.000000                    0             0.000000 #> ICAM3                0.000000                    0             0.000000 #> FAP                  0.000000                    0             0.000000 #> GZMB                 0.000000                    0             0.000000 #> TSC2                 0.000000                    0             0.000000 #>          X24_Y-99..Macrophage X29_Y-100..Macrophage X25_Y-100..Macrophage #> PDK4                 2.622667                     0                     0 #> TNFRSF17             0.000000                     0                     0 #> ICAM3                0.000000                     0                     0 #> FAP                  0.000000                     0                     0 #> GZMB                 0.000000                     0                     0 #> TSC2                 0.000000                     0                     0 #>          X27_Y-100..Macrophage X24_Y-100..Macrophage X30_Y-100..Macrophage #> PDK4                         0              5.167361                     0 #> TNFRSF17                     0              0.000000                     0 #> ICAM3                        0              0.000000                     0 #> FAP                          0              0.000000                     0 #> GZMB                         0              0.000000                     0 #> TSC2                         0              0.000000                     0 #>          X26_Y-101..Macrophage X29_Y-101..Macrophage X27_Y-101..Macrophage #> PDK4                         0              2.124001              2.247095 #> TNFRSF17                     0              0.000000              0.000000 #> ICAM3                        0              0.000000              0.000000 #> FAP                          0              0.000000              0.000000 #> GZMB                         0              2.124001              0.000000 #> TSC2                         0              0.000000              0.000000 #>          X28_Y-102..Macrophage X27_Y-102..Macrophage X25_Y-102..Macrophage #> PDK4                         0                     0                     0 #> TNFRSF17                     0                     0                     0 #> ICAM3                        0                     0                     0 #> FAP                          0                     0                     0 #> GZMB                         0                     0                     0 #> TSC2                         0                     0                     0 #>          X28_Y-103..Macrophage X23_Y-104..Macrophage X28_Y-101..Macrophage #> PDK4                         0              2.382278                     0 #> TNFRSF17                     0              0.000000                     0 #> ICAM3                        0              0.000000                     0 #> FAP                          0              0.000000                     0 #> GZMB                         0              0.000000                     0 #> TSC2                         0              0.000000                     0 #>          X78_Y-103..Macrophage X77_Y-103..Macrophage X76_Y-105..Macrophage #> PDK4                         0                     0                     0 #> TNFRSF17                     0                     0                     0 #> ICAM3                        0                     0                     0 #> FAP                          0                     0                     0 #> GZMB                         0                     0                     0 #> TSC2                         0                     0                     0 #>          X73_Y-106..Macrophage X75_Y-106..Macrophage X74_Y-107..Macrophage #> PDK4                  0.000000                     0             0.0000000 #> TNFRSF17              0.000000                     0             0.0000000 #> ICAM3                 0.000000                     0             0.0000000 #> FAP                   0.000000                     0             0.0000000 #> GZMB                  1.188274                     0             0.9506189 #> TSC2                  0.000000                     0             0.0000000 #>          X73_Y-107..Macrophage X74_Y-105..Macrophage X75_Y-107..Macrophage #> PDK4                  0.000000                     0                     0 #> TNFRSF17              0.000000                     0                     0 #> ICAM3                 0.000000                     0                     0 #> FAP                   0.000000                     0                     0 #> GZMB                  1.584365                     0                     0 #> TSC2                  0.000000                     0                     0 #>          X63_Y-97..Macrophage X62_Y-97..Macrophage X61_Y-98..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X62_Y-98..Macrophage X66_Y-98..Macrophage X64_Y-99..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X61_Y-99..Macrophage X62_Y-99..Macrophage X62_Y-100..Macrophage #> PDK4                        0            0.9697523             1.3171129 #> TNFRSF17                    0            0.0000000             0.0000000 #> ICAM3                       0            0.0000000             0.0000000 #> FAP                         0            0.0000000             0.0000000 #> GZMB                        0            0.0000000             0.7881696 #> TSC2                        0            0.0000000             0.0000000 #>          X64_Y-100..Macrophage X61_Y-100..Macrophage X63_Y-100..Macrophage #> PDK4                  1.576855                     0             0.6757949 #> TNFRSF17              0.000000                     0             0.0000000 #> ICAM3                 0.000000                     0             0.0000000 #> FAP                   0.000000                     0             0.0000000 #> GZMB                  0.000000                     0             0.6551227 #> TSC2                  0.000000                     0             0.0000000 #>          X60_Y-100..Macrophage X62_Y-101..Macrophage X63_Y-101..Macrophage #> PDK4                  0.751234             0.9956445             1.3306047 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             0.0000000             0.0000000 #> GZMB                  0.000000             1.7003808             0.7981848 #> TSC2                  0.000000             0.4215032             0.3688153 #>          X60_Y-101..Macrophage X63_Y-102..Macrophage X61_Y-102..Macrophage #> PDK4                  1.692747              2.737818              1.512170 #> TNFRSF17              0.000000              0.000000              0.000000 #> ICAM3                 0.000000              0.000000              0.000000 #> FAP                   0.000000              0.000000              0.000000 #> GZMB                  0.000000              0.000000              0.000000 #> TSC2                  0.000000              0.000000              0.759852 #>          X60_Y-102..Macrophage X62_Y-102..Macrophage X62_Y-103..Macrophage #> PDK4                   1.98778             0.9526356              1.017697 #> TNFRSF17               0.00000             0.0000000              0.000000 #> ICAM3                  0.00000             0.0000000              0.000000 #> FAP                    0.00000             0.0000000              0.000000 #> GZMB                   0.00000             0.0000000              0.000000 #> TSC2                   0.00000             0.0000000              0.000000 #>          X65_Y-103..Macrophage X64_Y-103..Macrophage X63_Y-103..Macrophage #> PDK4                  1.459591             0.6100838             0.0000000 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             0.0000000             0.0000000 #> GZMB                  0.000000             0.0000000             0.0000000 #> TSC2                  0.000000             0.0000000             0.9373996 #>          X64_Y-104..Macrophage X65_Y-104..Macrophage X65_Y-99..Macrophage #> PDK4                         0             0.6158461                    0 #> TNFRSF17                     0             0.0000000                    0 #> ICAM3                        0             0.0000000                    0 #> FAP                          0             0.0000000                    0 #> GZMB                         0             0.6595507                    0 #> TSC2                         0             0.0000000                    0 #>          X66_Y-101..Macrophage X65_Y-101..Macrophage X61_Y-101..Macrophage #> PDK4                         0                     0             0.7796220 #> TNFRSF17                     0                     0             0.0000000 #> ICAM3                        0                     0             0.0000000 #> FAP                          0                     0             0.0000000 #> GZMB                         0                     0             0.7624308 #> TSC2                         0                     0             0.0000000 #>          X65_Y-102..Macrophage X66_Y-102..Macrophage X66_Y-103..Macrophage #> PDK4                         0                     0              1.459591 #> TNFRSF17                     0                     0              0.000000 #> ICAM3                        0                     0              0.000000 #> FAP                          0                     0              0.000000 #> GZMB                         0                     0              0.000000 #> TSC2                         0                     0              0.000000 #>          X22_Y-104..Macrophage X22_Y-105..Macrophage X23_Y-105..Macrophage #> PDK4                         0                     0               1.50395 #> TNFRSF17                     0                     0               0.00000 #> ICAM3                        0                     0               0.00000 #> FAP                          0                     0               0.00000 #> GZMB                         0                     0               0.00000 #> TSC2                         0                     0               0.00000 #>          X22_Y-106..Macrophage X69_Y-85..Macrophage X71_Y-86..Macrophage #> PDK4                         0             1.171473                    0 #> TNFRSF17                     0             0.000000                    0 #> ICAM3                        0             0.000000                    0 #> FAP                          0             0.000000                    0 #> GZMB                         0             0.000000                    0 #> TSC2                         0             0.000000                    0 #>          X67_Y-86..Macrophage X70_Y-86..Macrophage X73_Y-86..Macrophage #> PDK4                0.0000000                    0             2.327773 #> TNFRSF17            0.0000000                    0             0.000000 #> ICAM3               0.0000000                    0             0.000000 #> FAP                 0.0000000                    0             0.000000 #> GZMB                0.7921824                    0             0.000000 #> TSC2                0.0000000                    0             0.000000 #>          X69_Y-86..Macrophage X68_Y-86..Macrophage X72_Y-87..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X67_Y-88..Macrophage X66_Y-88..Macrophage X73_Y-88..Macrophage #> PDK4                0.9686831             4.645283             1.548428 #> TNFRSF17            0.0000000             0.000000             0.000000 #> ICAM3               0.0000000             0.000000             0.000000 #> FAP                 0.0000000             0.000000             0.000000 #> GZMB                0.0000000             0.000000             0.000000 #> TSC2                1.8911079             0.000000             0.000000 #>          X72_Y-88..Macrophage X68_Y-88..Macrophage X71_Y-88..Macrophage #> PDK4                 2.322641             1.291578                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  0.000000             0.000000                    0 #> GZMB                 0.000000             0.000000                    0 #> TSC2                 0.000000             0.000000                    0 #>          X68_Y-89..Macrophage X68_Y-90..Macrophage X69_Y-90..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X67_Y-90..Macrophage X72_Y-91..Macrophage X67_Y-91..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X69_Y-87..Macrophage X72_Y-89..Macrophage X71_Y-90..Macrophage #> PDK4                        0                    0             3.951636 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X25_Y-104..Macrophage X29_Y-104..Macrophage X28_Y-105..Macrophage #> PDK4                         0                     0              1.968116 #> TNFRSF17                     0                     0              0.000000 #> ICAM3                        0                     0              0.000000 #> FAP                          0                     0              0.000000 #> GZMB                         0                     0              0.000000 #> TSC2                         0                     0              0.000000 #>          X25_Y-105..Macrophage X24_Y-105..Macrophage X27_Y-105..Macrophage #> PDK4                  1.971146              3.201997             0.6040406 #> TNFRSF17              0.000000              0.000000             0.0000000 #> ICAM3                 0.000000              0.000000             0.0000000 #> FAP                   0.000000              0.000000             0.0000000 #> GZMB                  0.000000              0.000000             0.0000000 #> TSC2                  0.000000              0.000000             0.0000000 #>          X26_Y-105..Macrophage X29_Y-105..Macrophage X24_Y-106..Macrophage #> PDK4                  2.766882              1.441937              2.265001 #> TNFRSF17              0.000000              0.000000              0.000000 #> ICAM3                 0.000000              0.000000              0.000000 #> FAP                   0.000000              0.000000              0.000000 #> GZMB                  0.000000              0.000000              0.000000 #> TSC2                  0.000000              0.000000              0.000000 #>          X27_Y-106..Macrophage X29_Y-106..Macrophage X25_Y-106..Macrophage #> PDK4                         0              1.441937              1.872701 #> TNFRSF17                     0              0.000000              0.000000 #> ICAM3                        0              0.000000              0.000000 #> FAP                          0              0.000000              0.000000 #> GZMB                         0              0.000000              0.000000 #> TSC2                         0              0.000000              0.000000 #>          X26_Y-106..Macrophage X28_Y-106..Macrophage X28_Y-107..Macrophage #> PDK4                         0              1.630514               2.44577 #> TNFRSF17                     0              0.000000               0.00000 #> ICAM3                        0              0.000000               0.00000 #> FAP                          0              0.000000               0.00000 #> GZMB                         0              0.000000               0.00000 #> TSC2                         0              0.000000               0.00000 #>          X25_Y-107..Macrophage X26_Y-107..Macrophage X27_Y-107..Macrophage #> PDK4                  1.442999                     0                     0 #> TNFRSF17              0.000000                     0                     0 #> ICAM3                 0.000000                     0                     0 #> FAP                   0.000000                     0                     0 #> GZMB                  0.000000                     0                     0 #> TSC2                  0.000000                     0                     0 #>          X69_Y-98..Macrophage X71_Y-98..Macrophage X68_Y-99..Macrophage #> PDK4                        0                    0              4.15104 #> TNFRSF17                    0                    0              0.00000 #> ICAM3                       0                    0              0.00000 #> FAP                         0                    0              0.00000 #> GZMB                        0                    0              0.00000 #> TSC2                        0                    0              0.00000 #>          X70_Y-100..Macrophage X72_Y-100..Macrophage X68_Y-100..Macrophage #> PDK4                         0                     0                     0 #> TNFRSF17                     0                     0                     0 #> ICAM3                        0                     0                     0 #> FAP                          0                     0                     0 #> GZMB                         0                     0                     0 #> TSC2                         0                     0                     0 #>          X72_Y-102..Macrophage X71_Y-102..Macrophage X67_Y-98..Macrophage #> PDK4                         0                     0                    0 #> TNFRSF17                     0                     0                    0 #> ICAM3                        0                     0                    0 #> FAP                          0                     0                    0 #> GZMB                         0                     0                    0 #> TSC2                         0                     0                    0 #>          X70_Y-102..Macrophage X72_Y-104..Macrophage X71_Y-104..Macrophage #> PDK4                         0              4.730565              0.000000 #> TNFRSF17                     0              0.000000              0.000000 #> ICAM3                        0              0.000000              0.000000 #> FAP                          0              0.000000              0.000000 #> GZMB                         0              0.000000              1.034704 #> TSC2                         0              0.000000              0.000000 #>          X68_Y-104..Macrophage X70_Y-104..Macrophage X71_Y-105..Macrophage #> PDK4                         0              1.052012             1.7686346 #> TNFRSF17                     0              0.000000             0.0000000 #> ICAM3                        0              0.000000             0.0000000 #> FAP                          0              0.000000             0.0000000 #> GZMB                         0              0.000000             0.8277628 #> TSC2                         0              0.000000             0.0000000 #>          X70_Y-105..Macrophage X68_Y-105..Macrophage X72_Y-105..Macrophage #> PDK4                  2.104024              1.276387                     0 #> TNFRSF17              0.000000              0.000000                     0 #> ICAM3                 0.000000              0.000000                     0 #> FAP                   0.000000              0.000000                     0 #> GZMB                  0.000000              0.000000                     0 #> TSC2                  0.000000              0.000000                     0 #>          X67_Y-105..Macrophage X69_Y-106..Macrophage X71_Y-106..Macrophage #> PDK4                         0              0.000000              1.545042 #> TNFRSF17                     0              0.000000              0.000000 #> ICAM3                        0              0.000000              0.000000 #> FAP                          0              0.000000              0.000000 #> GZMB                         0              1.879895              0.000000 #> TSC2                         0              0.000000              0.000000 #>          X67_Y-106..Macrophage X66_Y-106..Macrophage X70_Y-106..Macrophage #> PDK4                         0                     0              0.000000 #> TNFRSF17                     0                     0              0.000000 #> ICAM3                        0                     0              0.000000 #> FAP                          0                     0              0.000000 #> GZMB                         0                     0              1.879895 #> TSC2                         0                     0              0.000000 #>          X72_Y-106..Macrophage X67_Y-107..Macrophage X71_Y-107..Macrophage #> PDK4                         0             0.7241396              1.519148 #> TNFRSF17                     0             0.0000000              0.000000 #> ICAM3                        0             0.0000000              0.000000 #> FAP                          0             0.0000000              0.000000 #> GZMB                         0             0.0000000              0.000000 #> TSC2                         0             0.0000000              0.000000 #>          X66_Y-107..Macrophage X69_Y-107..Macrophage X68_Y-107..Macrophage #> PDK4                   1.61865                     0             0.8550494 #> TNFRSF17               0.00000                     0             0.0000000 #> ICAM3                  0.00000                     0             0.0000000 #> FAP                    0.00000                     0             0.0000000 #> GZMB                   0.00000                     0             0.8442717 #> TSC2                   0.00000                     0             0.0000000 #>          X67_Y-104..Macrophage X68_Y-106..Macrophage X56_Y-103..Macrophage #> PDK4                         0              1.710099                     0 #> TNFRSF17                     0              0.000000                     0 #> ICAM3                        0              0.000000                     0 #> FAP                          0              0.000000                     0 #> GZMB                         0              0.000000                     0 #> TSC2                         0              0.000000                     0 #>          X58_Y-103..Macrophage X58_Y-104..Macrophage X55_Y-104..Macrophage #> PDK4                         0                     0                     0 #> TNFRSF17                     0                     0                     0 #> ICAM3                        0                     0                     0 #> FAP                          0                     0                     0 #> GZMB                         0                     0                     0 #> TSC2                         0                     0                     0 #>          X54_Y-104..Macrophage X59_Y-105..Macrophage X60_Y-105..Macrophage #> PDK4                 0.0000000             1.3964319             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.0000000             0.0000000 #> GZMB                 0.4247396             0.5849204             0.0000000 #> TSC2                 0.0000000             0.4087870             0.4598853 #>          X57_Y-105..Macrophage X58_Y-105..Macrophage X55_Y-106..Macrophage #> PDK4                 0.9955345                     0                     0 #> TNFRSF17             0.0000000                     0                     0 #> ICAM3                0.0000000                     0                     0 #> FAP                  0.0000000                     0                     0 #> GZMB                 0.0000000                     0                     0 #> TSC2                 0.0000000                     0                     0 #>          X58_Y-106..Macrophage X57_Y-106..Macrophage X56_Y-106..Macrophage #> PDK4                         0             0.5520564                     0 #> TNFRSF17                     0             0.0000000                     0 #> ICAM3                        0             0.0000000                     0 #> FAP                          0             0.0000000                     0 #> GZMB                         0             0.6037002                     0 #> TSC2                         0             0.0000000                     0 #>          X59_Y-106..Macrophage X56_Y-107..Macrophage X55_Y-107..Macrophage #> PDK4                 0.7999609             0.0000000             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.0000000             0.0000000 #> GZMB                 0.0000000             0.3683869             0.7367739 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X57_Y-107..Macrophage X59_Y-104..Macrophage X55_Y-105..Macrophage #> PDK4                 0.0000000             1.5383841                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.0000000             0.0000000                     0 #> GZMB                 0.5878309             0.6580354                     0 #> TSC2                 0.0000000             0.0000000                     0 #>          X54_Y-105..Macrophage X60_Y-106..Macrophage X61_Y-104..Macrophage #> PDK4                 0.0000000                     0                     0 #> TNFRSF17             0.0000000                     0                     0 #> ICAM3                0.0000000                     0                     0 #> FAP                  0.0000000                     0                     0 #> GZMB                 0.4854166                     0                     0 #> TSC2                 0.0000000                     0                     0 #>          X65_Y-105..Macrophage X64_Y-105..Macrophage X62_Y-105..Macrophage #> PDK4                 0.2701184                     0             0.8622388 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.0000000                     0             0.0000000 #> GZMB                 1.0664376                     0             0.8579341 #> TSC2                 0.0000000                     0             0.0000000 #>          X61_Y-105..Macrophage X63_Y-105..Macrophage X63_Y-106..Macrophage #> PDK4                         0              1.666585              1.666585 #> TNFRSF17                     0              0.000000              0.000000 #> ICAM3                        0              0.000000              0.000000 #> FAP                          0              0.000000              0.000000 #> GZMB                         0              0.000000              0.000000 #> TSC2                         0              0.000000              0.000000 #>          X62_Y-106..Macrophage X65_Y-106..Macrophage X64_Y-106..Macrophage #> PDK4                  1.077798              0.000000                     0 #> TNFRSF17              0.000000              0.000000                     0 #> ICAM3                 0.000000              0.000000                     0 #> FAP                   0.000000              0.000000                     0 #> GZMB                  1.072418              1.256816                     0 #> TSC2                  0.000000              0.000000                     0 #>          X65_Y-107..Macrophage X62_Y-104..Macrophage X49_Y-103..Macrophage #> PDK4                  0.000000                     0             0.3683447 #> TNFRSF17              0.000000                     0             0.0000000 #> ICAM3                 0.000000                     0             0.0000000 #> FAP                   0.000000                     0             0.0000000 #> GZMB                  1.256816                     0             0.0000000 #> TSC2                  0.000000                     0             0.0000000 #>          X53_Y-105..Macrophage X51_Y-105..Macrophage X50_Y-106..Macrophage #> PDK4                         0             0.0000000                     0 #> TNFRSF17                     0             0.0000000                     0 #> ICAM3                        0             0.0000000                     0 #> FAP                          0             0.0000000                     0 #> GZMB                         0             0.6887931                     0 #> TSC2                         0             0.0000000                     0 #>          X51_Y-106..Macrophage X54_Y-106..Macrophage X49_Y-106..Macrophage #> PDK4                 0.0000000                     0                     0 #> TNFRSF17             0.0000000                     0                     0 #> ICAM3                0.0000000                     0                     0 #> FAP                  0.0000000                     0                     0 #> GZMB                 0.8265518                     0                     0 #> TSC2                 0.0000000                     0                     0 #>          X53_Y-106..Macrophage X52_Y-106..Macrophage X53_Y-107..Macrophage #> PDK4                         0                     0                     0 #> TNFRSF17                     0                     0                     0 #> ICAM3                        0                     0                     0 #> FAP                          0                     0                     0 #> GZMB                         0                     0                     0 #> TSC2                         0                     0                     0 #>          X50_Y-107..Macrophage X48_Y-107..Macrophage X49_Y-104..Macrophage #> PDK4                 0.0000000              1.124369             0.8287755 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.0000000              0.000000             0.0000000 #> GZMB                 0.0000000              0.000000             0.0000000 #> TSC2                 0.6579771              0.000000             0.0000000 #>          X53_Y-104..Macrophage X52_Y-105..Macrophage X50_Y-105..Macrophage #> PDK4                         0                     0                     0 #> TNFRSF17                     0                     0                     0 #> ICAM3                        0                     0                     0 #> FAP                          0                     0                     0 #> GZMB                         0                     0                     0 #> TSC2                         0                     0                     0 #>          X51_Y-107..Macrophage X31_Y-104..Macrophage X33_Y-104..Macrophage #> PDK4                         0                     0                     0 #> TNFRSF17                     0                     0                     0 #> ICAM3                        0                     0                     0 #> FAP                          0                     0                     0 #> GZMB                         0                     0                     0 #> TSC2                         0                     0                     0 #>          X32_Y-104..Macrophage X35_Y-105..Macrophage X31_Y-105..Macrophage #> PDK4                 0.9181351              3.725352               1.20144 #> TNFRSF17             0.0000000              0.000000               0.00000 #> ICAM3                0.0000000              0.000000               0.00000 #> FAP                  0.0000000              0.000000               0.00000 #> GZMB                 0.0000000              0.000000               0.00000 #> TSC2                 0.0000000              0.000000               0.00000 #>          X30_Y-105..Macrophage X36_Y-105..Macrophage X33_Y-105..Macrophage #> PDK4                  1.826314              2.413289                     0 #> TNFRSF17              0.000000              0.000000                     0 #> ICAM3                 0.000000              0.000000                     0 #> FAP                   0.000000              0.000000                     0 #> GZMB                  0.000000              0.000000                     0 #> TSC2                  0.000000              0.000000                     0 #>          X32_Y-105..Macrophage X32_Y-106..Macrophage X30_Y-106..Macrophage #> PDK4                 0.9968292              1.329106              2.162906 #> TNFRSF17             0.0000000              0.000000              0.000000 #> ICAM3                0.0000000              0.000000              0.000000 #> FAP                  0.0000000              0.000000              0.000000 #> GZMB                 0.0000000              0.000000              0.000000 #> TSC2                 0.0000000              0.000000              0.000000 #>          X35_Y-106..Macrophage X31_Y-106..Macrophage X34_Y-106..Macrophage #> PDK4                  2.442493                     0              2.080357 #> TNFRSF17              0.000000                     0              0.000000 #> ICAM3                 0.000000                     0              0.000000 #> FAP                   0.000000                     0              0.000000 #> GZMB                  0.000000                     0              0.000000 #> TSC2                  0.000000                     0              0.000000 #>          X32_Y-107..Macrophage X33_Y-107..Macrophage X30_Y-107..Macrophage #> PDK4                  0.000000                     0                     0 #> TNFRSF17              0.000000                     0                     0 #> ICAM3                 0.000000                     0                     0 #> FAP                   0.000000                     0                     0 #> GZMB                  1.313893                     0                     0 #> TSC2                  0.000000                     0                     0 #>          X34_Y-104..Macrophage X33_Y-106..Macrophage X34_Y-107..Macrophage #> PDK4                         0                     0              1.396223 #> TNFRSF17                     0                     0              0.000000 #> ICAM3                        0                     0              0.000000 #> FAP                          0                     0              0.000000 #> GZMB                         0                     0              0.000000 #> TSC2                         0                     0              0.000000 #>          X42_Y-103..Macrophage X43_Y-103..Macrophage X44_Y-103..Macrophage #> PDK4                 0.4584823             0.9530384             0.7624308 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.0000000             0.0000000 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X45_Y-104..Macrophage X46_Y-104..Macrophage X47_Y-105..Macrophage #> PDK4                         0             0.0000000               0.00000 #> TNFRSF17                     0             0.0000000               0.00000 #> ICAM3                        0             0.0000000               0.00000 #> FAP                          0             0.0000000               0.00000 #> GZMB                         0             0.9175531               1.37633 #> TSC2                         0             0.0000000               0.00000 #>          X42_Y-105..Macrophage X48_Y-105..Macrophage X42_Y-106..Macrophage #> PDK4                  0.659978                     0             0.6635323 #> TNFRSF17              0.000000                     0             0.0000000 #> ICAM3                 0.000000                     0             0.0000000 #> FAP                   0.000000                     0             0.0000000 #> GZMB                  0.000000                     0             0.0000000 #> TSC2                  0.000000                     0             0.0000000 #>          X46_Y-106..Macrophage X42_Y-107..Macrophage X43_Y-107..Macrophage #> PDK4                 0.7396178                     0                     0 #> TNFRSF17             0.0000000                     0                     0 #> ICAM3                0.0000000                     0                     0 #> FAP                  0.0000000                     0                     0 #> GZMB                 0.0000000                     0                     0 #> TSC2                 0.8853154                     0                     0 #>          X45_Y-107..Macrophage X44_Y-104..Macrophage X47_Y-104..Macrophage #> PDK4                  1.939681                     0              2.508094 #> TNFRSF17              0.000000                     0              0.000000 #> ICAM3                 0.000000                     0              0.000000 #> FAP                   0.000000                     0              0.000000 #> GZMB                  0.000000                     0              0.000000 #> TSC2                  2.213289                     0              0.000000 #>          X48_Y-106..Macrophage X55_Y-98..Macrophage X60_Y-98..Macrophage #> PDK4                         0            0.0000000              0.00000 #> TNFRSF17                     0            0.0000000              0.00000 #> ICAM3                        0            0.0000000              0.00000 #> FAP                          0            0.0000000              0.00000 #> GZMB                         0            0.0000000              1.84332 #> TSC2                         0            0.3768183              0.00000 #>          X58_Y-98..Macrophage X59_Y-98..Macrophage X58_Y-99..Macrophage #> PDK4                        0                    0              1.37558 #> TNFRSF17                    0                    0              0.00000 #> ICAM3                       0                    0              0.00000 #> FAP                         0                    0              0.00000 #> GZMB                        0                    0              0.00000 #> TSC2                        0                    0              0.00000 #>          X60_Y-99..Macrophage X57_Y-99..Macrophage X54_Y-99..Macrophage #> PDK4                1.1717495             2.927429             1.644659 #> TNFRSF17            0.0000000             0.000000             0.000000 #> ICAM3               0.0000000             0.000000             0.000000 #> FAP                 0.0000000             0.000000             0.000000 #> GZMB                0.9216599             0.000000             0.000000 #> TSC2                0.0000000             0.000000             0.000000 #>          X59_Y-100..Macrophage X56_Y-100..Macrophage X58_Y-100..Macrophage #> PDK4                  1.502468                     0               1.84332 #> TNFRSF17              0.000000                     0               0.00000 #> ICAM3                 0.000000                     0               0.00000 #> FAP                   0.000000                     0               0.00000 #> GZMB                  0.000000                     0               0.00000 #> TSC2                  0.000000                     0               0.00000 #>          X59_Y-101..Macrophage X58_Y-101..Macrophage X56_Y-101..Macrophage #> PDK4                  1.662692              3.325383                     0 #> TNFRSF17              0.000000              0.000000                     0 #> ICAM3                 0.000000              0.000000                     0 #> FAP                   0.000000              0.000000                     0 #> GZMB                  0.000000              0.000000                     0 #> TSC2                  1.662692              3.325383                     0 #>          X57_Y-101..Macrophage X58_Y-102..Macrophage X56_Y-102..Macrophage #> PDK4                  4.175964                     0                     0 #> TNFRSF17              0.000000                     0                     0 #> ICAM3                 0.000000                     0                     0 #> FAP                   0.000000                     0                     0 #> GZMB                  0.000000                     0                     0 #> TSC2                  0.000000                     0                     0 #>          X59_Y-102..Macrophage X59_Y-103..Macrophage X60_Y-103..Macrophage #> PDK4                         0             0.7564919              2.209223 #> TNFRSF17                     0             0.0000000              0.000000 #> ICAM3                        0             0.0000000              0.000000 #> FAP                          0             0.0000000              0.000000 #> GZMB                         0             0.0000000              0.000000 #> TSC2                         0             0.0000000              0.000000 #>          X57_Y-103..Macrophage X56_Y-99..Macrophage X55_Y-99..Macrophage #> PDK4                         0                    0                    0 #> TNFRSF17                     0                    0                    0 #> ICAM3                        0                    0                    0 #> FAP                          0                    0                    0 #> GZMB                         0                    0                    0 #> TSC2                         0                    0                    0 #>          X55_Y-100..Macrophage X57_Y-100..Macrophage X39_Y-97..Macrophage #> PDK4                         0               1.84332             1.733741 #> TNFRSF17                     0               0.00000             0.000000 #> ICAM3                        0               0.00000             0.000000 #> FAP                          0               0.00000             0.000000 #> GZMB                         0               0.00000             0.000000 #> TSC2                         0               0.00000             0.000000 #>          X38_Y-98..Macrophage X37_Y-98..Macrophage X40_Y-98..Macrophage #> PDK4                        0             1.082844             1.588185 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             0.000000             0.000000 #> GZMB                        0             0.000000             0.000000 #> TSC2                        0             0.000000             0.000000 #>          X40_Y-99..Macrophage X41_Y-99..Macrophage X39_Y-99..Macrophage #> PDK4                        0                    0             2.399883 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X39_Y-100..Macrophage X37_Y-100..Macrophage X38_Y-100..Macrophage #> PDK4                 0.7999609                     0              1.489428 #> TNFRSF17             0.0000000                     0              0.000000 #> ICAM3                0.0000000                     0              0.000000 #> FAP                  0.0000000                     0              0.000000 #> GZMB                 0.0000000                     0              0.000000 #> TSC2                 0.0000000                     0              0.000000 #>          X40_Y-100..Macrophage X41_Y-100..Macrophage X39_Y-101..Macrophage #> PDK4                         0                     0                     0 #> TNFRSF17                     0                     0                     0 #> ICAM3                        0                     0                     0 #> FAP                          0                     0                     0 #> GZMB                         0                     0                     0 #> TSC2                         0                     0                     0 #>          X37_Y-101..Macrophage X41_Y-101..Macrophage X38_Y-101..Macrophage #> PDK4                         0              5.430541             0.7447139 #> TNFRSF17                     0              0.000000             0.0000000 #> ICAM3                        0              0.000000             0.0000000 #> FAP                          0              0.000000             0.0000000 #> GZMB                         0              0.000000             0.0000000 #> TSC2                         0              0.000000             0.0000000 #>          X41_Y-102..Macrophage X42_Y-102..Macrophage X38_Y-103..Macrophage #> PDK4                 0.9923803              1.051135              2.894775 #> TNFRSF17             0.0000000              0.000000              0.000000 #> ICAM3                0.0000000              0.000000              0.000000 #> FAP                  0.0000000              0.000000              0.000000 #> GZMB                 0.6323682              0.000000              0.000000 #> TSC2                 0.0000000              0.000000              0.000000 #>          X41_Y-103..Macrophage X37_Y-103..Macrophage X40_Y-103..Macrophage #> PDK4                         0                     0                     0 #> TNFRSF17                     0                     0                     0 #> ICAM3                        0                     0                     0 #> FAP                          0                     0                     0 #> GZMB                         0                     0                     0 #> TSC2                         0                     0                     0 #>          X39_Y-103..Macrophage X61_Y-86..Macrophage X60_Y-86..Macrophage #> PDK4                  5.054737            1.7403408            0.7595742 #> TNFRSF17              0.000000            0.0000000            0.0000000 #> ICAM3                 0.000000            0.0000000            0.0000000 #> FAP                   0.000000            0.0000000            0.0000000 #> GZMB                  0.000000            0.4282238            0.0000000 #> TSC2                  0.000000            0.0000000            0.0000000 #>          X62_Y-86..Macrophage X63_Y-86..Macrophage X66_Y-86..Macrophage #> PDK4                 1.067153                    0            1.2435692 #> TNFRSF17             0.000000                    0            0.0000000 #> ICAM3                0.000000                    0            0.0000000 #> FAP                  0.000000                    0            0.0000000 #> GZMB                 0.000000                    0            0.8318796 #> TSC2                 0.000000                    0            0.0000000 #>          X64_Y-86..Macrophage X61_Y-87..Macrophage X62_Y-87..Macrophage #> PDK4                        0             1.424849            0.7438968 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             0.000000            0.0000000 #> GZMB                        0             0.000000            0.0000000 #> TSC2                        0             0.000000            0.7839302 #>          X63_Y-87..Macrophage X62_Y-88..Macrophage X61_Y-88..Macrophage #> PDK4                        0            0.7844143                    0 #> TNFRSF17                    0            0.0000000                    0 #> ICAM3                       0            0.0000000                    0 #> FAP                         0            0.0000000                    0 #> GZMB                        0            0.0000000                    0 #> TSC2                        0            1.5678605                    0 #>          X61_Y-89..Macrophage X63_Y-89..Macrophage X64_Y-89..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X62_Y-89..Macrophage X63_Y-90..Macrophage X61_Y-90..Macrophage #> PDK4                        0            0.9451821             1.978732 #> TNFRSF17                    0            0.0000000             0.000000 #> ICAM3                       0            0.0000000             0.000000 #> FAP                         0            0.0000000             0.000000 #> GZMB                        0            0.0000000             1.423642 #> TSC2                        0            0.0000000             0.000000 #>          X62_Y-90..Macrophage X66_Y-90..Macrophage X63_Y-88..Macrophage #> PDK4                 1.454123                    0                    0 #> TNFRSF17             0.000000                    0                    0 #> ICAM3                0.000000                    0                    0 #> FAP                  0.000000                    0                    0 #> GZMB                 0.000000                    0                    0 #> TSC2                 0.000000                    0                    0 #>          X60_Y-90..Macrophage X64_Y-90..Macrophage X63_Y-91..Macrophage #> PDK4                 1.516039                    0            0.9672564 #> TNFRSF17             0.000000                    0            0.0000000 #> ICAM3                0.000000                    0            0.0000000 #> FAP                  0.000000                    0            0.0000000 #> GZMB                 0.000000                    0            0.0000000 #> TSC2                 0.000000                    0            0.0000000 #>          X38_Y-92..Macrophage X39_Y-93..Macrophage X37_Y-93..Macrophage #> PDK4                 0.000000                    0            0.9398992 #> TNFRSF17             0.000000                    0            0.0000000 #> ICAM3                0.000000                    0            0.0000000 #> FAP                  0.000000                    0            0.0000000 #> GZMB                 3.782335                    0            0.0000000 #> TSC2                 0.000000                    0            0.0000000 #>          X36_Y-93..Macrophage X36_Y-94..Macrophage X40_Y-94..Macrophage #> PDK4                 1.778634             1.792318             1.244429 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  0.000000             0.000000             0.000000 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             0.000000 #>          X39_Y-94..Macrophage X39_Y-95..Macrophage X42_Y-95..Macrophage #> PDK4                0.0000000            0.0000000                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.0000000            0.0000000                    0 #> GZMB                0.6697879            0.8372349                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X37_Y-95..Macrophage X41_Y-96..Macrophage X39_Y-96..Macrophage #> PDK4                 4.394449                    0            0.6934963 #> TNFRSF17             0.000000                    0            0.0000000 #> ICAM3                0.000000                    0            0.0000000 #> FAP                  0.000000                    0            0.0000000 #> GZMB                 0.000000                    0            0.0000000 #> TSC2                 0.000000                    0            0.0000000 #>          X41_Y-97..Macrophage X37_Y-97..Macrophage X37_Y-92..Macrophage #> PDK4                 1.612094             1.624265             0.000000 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  0.000000             0.000000             0.000000 #> GZMB                 0.000000             0.000000             1.260778 #> TSC2                 0.000000             0.000000             0.000000 #>          X41_Y-94..Macrophage X37_Y-96..Macrophage X41_Y-104..Macrophage #> PDK4                        0             1.364796              1.297643 #> TNFRSF17                    0             0.000000              0.000000 #> ICAM3                       0             0.000000              0.000000 #> FAP                         0             0.000000              0.000000 #> GZMB                        0             1.847129              0.000000 #> TSC2                        0             0.000000              0.000000 #>          X36_Y-104..Macrophage X41_Y-105..Macrophage X40_Y-105..Macrophage #> PDK4                   4.99761              1.605025              1.278432 #> TNFRSF17               0.00000              0.000000              0.000000 #> ICAM3                  0.00000              0.000000              0.000000 #> FAP                    0.00000              0.000000              0.000000 #> GZMB                   0.00000              0.000000              0.000000 #> TSC2                   0.00000              0.000000              0.000000 #>          X41_Y-106..Macrophage X39_Y-106..Macrophage X37_Y-106..Macrophage #> PDK4                 0.8853154                     0              1.594193 #> TNFRSF17             0.0000000                     0              0.000000 #> ICAM3                0.0000000                     0              0.000000 #> FAP                  0.0000000                     0              0.000000 #> GZMB                 0.0000000                     0              0.000000 #> TSC2                 0.0000000                     0              0.000000 #>          X38_Y-106..Macrophage X37_Y-107..Macrophage X38_Y-107..Macrophage #> PDK4                  1.391988              1.992741                     0 #> TNFRSF17              0.000000              0.000000                     0 #> ICAM3                 0.000000              0.000000                     0 #> FAP                   0.000000              0.000000                     0 #> GZMB                  0.000000              0.000000                     0 #> TSC2                  0.000000              0.000000                     0 #>          X40_Y-107..Macrophage X40_Y-106..Macrophage X41_Y-107..Macrophage #> PDK4                         0                     0                     0 #> TNFRSF17                     0                     0                     0 #> ICAM3                        0                     0                     0 #> FAP                          0                     0                     0 #> GZMB                         0                     0                     0 #> TSC2                         0                     0                     0 #>          X53_Y-86..Macrophage X51_Y-86..Macrophage X50_Y-86..Macrophage #> PDK4                        0            0.6157095            0.5119313 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.0000000            0.0000000 #> GZMB                        0            0.0000000            0.0000000 #> TSC2                        0            0.0000000            0.0000000 #>          X51_Y-87..Macrophage X50_Y-87..Macrophage X53_Y-87..Macrophage #> PDK4                0.0000000            0.3412875            1.1317209 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            0.0000000            0.0000000 #> GZMB                0.7088218            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.7598619 #>          X52_Y-87..Macrophage X49_Y-87..Macrophage X50_Y-88..Macrophage #> PDK4                0.9054788            0.8922617                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.0000000            0.0000000                    0 #> GZMB                0.4510684            0.0000000                    0 #> TSC2                0.3324332            0.9226102                    0 #>          X53_Y-88..Macrophage X49_Y-88..Macrophage X54_Y-88..Macrophage #> PDK4                0.3459063            0.4461309            1.4334452 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            0.0000000            0.0000000 #> GZMB                0.2499922            0.0000000            0.3423367 #> TSC2                0.5392641            0.4613051            0.3643923 #>          X51_Y-88..Macrophage X52_Y-88..Macrophage X53_Y-89..Macrophage #> PDK4                  1.01758            0.8119746             1.137039 #> TNFRSF17              0.00000            0.0000000             0.000000 #> ICAM3                 0.00000            0.0000000             0.000000 #> FAP                   0.00000            0.0000000             0.000000 #> GZMB                  0.00000            0.0000000             0.000000 #> TSC2                  0.00000            0.4063073             0.000000 #>          X54_Y-89..Macrophage X50_Y-89..Macrophage X52_Y-89..Macrophage #> PDK4                2.3964776             1.462272                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 0.0000000             0.000000                    0 #> GZMB                0.3765704             0.000000                    0 #> TSC2                0.0000000             0.000000                    0 #>          X49_Y-89..Macrophage X51_Y-90..Macrophage X52_Y-90..Macrophage #> PDK4                 1.492281               2.0486             1.267846 #> TNFRSF17             0.000000               0.0000             0.000000 #> ICAM3                0.000000               0.0000             0.000000 #> FAP                  0.000000               0.0000             0.000000 #> GZMB                 0.000000               0.0000             0.000000 #> TSC2                 0.000000               0.0000             0.000000 #>          X53_Y-90..Macrophage X54_Y-90..Macrophage X49_Y-91..Macrophage #> PDK4                 1.267846            0.7175272             0.000000 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  0.000000            0.0000000             0.000000 #> GZMB                 0.000000            0.0000000             1.330841 #> TSC2                 0.000000            0.0000000             0.000000 #>          X52_Y-86..Macrophage X54_Y-87..Macrophage X49_Y-90..Macrophage #> PDK4                        0            0.9916916                    0 #> TNFRSF17                    0            0.0000000                    0 #> ICAM3                       0            0.0000000                    0 #> FAP                         0            0.0000000                    0 #> GZMB                        0            0.0000000                    0 #> TSC2                        0            0.0000000                    0 #>          X48_Y-90..Macrophage X52_Y-91..Macrophage X50_Y-91..Macrophage #> PDK4                        0             1.901769             0.000000 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             0.000000             0.000000 #> GZMB                        0             0.000000             3.992524 #> TSC2                        0             0.000000             0.000000 #>          X59_Y-85..Macrophage X56_Y-86..Macrophage X59_Y-86..Macrophage #> PDK4                 1.670264                    0            0.9733472 #> TNFRSF17             0.000000                    0            0.0000000 #> ICAM3                0.000000                    0            0.0000000 #> FAP                  0.000000                    0            0.0000000 #> GZMB                 0.000000                    0            0.0000000 #> TSC2                 0.000000                    0            0.0000000 #>          X58_Y-86..Macrophage X54_Y-86..Macrophage X56_Y-87..Macrophage #> PDK4                0.4992796                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 0.0000000                    0                    0 #> GZMB                0.0000000                    0                    0 #> TSC2                0.4907079                    0                    0 #>          X60_Y-87..Macrophage X57_Y-87..Macrophage X58_Y-87..Macrophage #> PDK4                 3.197619                    0             1.472099 #> TNFRSF17             0.000000                    0             0.000000 #> ICAM3                0.000000                    0             0.000000 #> FAP                  0.000000                    0             0.000000 #> GZMB                 0.000000                    0             0.000000 #> TSC2                 0.000000                    0             0.000000 #>          X58_Y-88..Macrophage X59_Y-87..Macrophage X57_Y-88..Macrophage #> PDK4                1.2702814             1.840124            0.7257344 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.0000000             0.000000            0.0000000 #> GZMB                0.5046065             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.0000000 #>          X55_Y-88..Macrophage X59_Y-88..Macrophage X56_Y-88..Macrophage #> PDK4                        0            0.5649289                    0 #> TNFRSF17                    0            0.0000000                    0 #> ICAM3                       0            0.0000000                    0 #> FAP                         0            0.0000000                    0 #> GZMB                        0            0.0000000                    0 #> TSC2                        0            0.6016900                    0 #>          X58_Y-89..Macrophage X55_Y-89..Macrophage X56_Y-89..Macrophage #> PDK4                1.1355644            0.5043279            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            0.0000000            0.0000000 #> GZMB                0.5619661            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.4617821 #>          X57_Y-89..Macrophage X59_Y-89..Macrophage X55_Y-90..Macrophage #> PDK4                1.2977878            0.8473933            0.2695304 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            0.0000000            0.0000000 #> GZMB                0.3964765            0.0000000            0.3169616 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X58_Y-90..Macrophage X57_Y-90..Macrophage X56_Y-90..Macrophage #> PDK4                1.4039788            1.4211448             0.363856 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.0000000            0.0000000             0.000000 #> GZMB                0.2023992            0.2457704             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X54_Y-85..Macrophage X55_Y-86..Macrophage X59_Y-90..Macrophage #> PDK4                 1.768058                    0             1.846648 #> TNFRSF17             0.000000                    0             0.000000 #> ICAM3                0.000000                    0             0.000000 #> FAP                  0.000000                    0             0.000000 #> GZMB                 0.000000                    0             0.000000 #> TSC2                 0.000000                    0             0.000000 #>          X56_Y-91..Macrophage X55_Y-64..Macrophage X56_Y-65..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X55_Y-65..Macrophage X59_Y-66..Macrophage X57_Y-66..Macrophage #> PDK4                 1.045658                    0                    0 #> TNFRSF17             0.000000                    0                    0 #> ICAM3                0.000000                    0                    0 #> FAP                  0.000000                    0                    0 #> GZMB                 0.000000                    0                    0 #> TSC2                 0.000000                    0                    0 #>          X56_Y-66..Macrophage X58_Y-66..Macrophage X58_Y-67..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X69_Y-64..Macrophage X72_Y-65..Macrophage X71_Y-65..Macrophage #> PDK4                 3.615404            0.5127672             1.211965 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  0.000000            0.0000000             0.000000 #> GZMB                 0.000000            0.0000000             0.000000 #> TSC2                 0.000000            0.6347209             0.000000 #>          X70_Y-65..Macrophage X67_Y-65..Macrophage X52_Y-97..Macrophage #> PDK4                        0                    0             3.270194 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X50_Y-98..Macrophage X49_Y-98..Macrophage X54_Y-98..Macrophage #> PDK4                        0              1.22262                    0 #> TNFRSF17                    0              0.00000                    0 #> ICAM3                       0              0.00000                    0 #> FAP                         0              0.00000                    0 #> GZMB                        0              0.00000                    0 #> TSC2                        0              0.00000                    0 #>          X52_Y-98..Macrophage X48_Y-99..Macrophage X49_Y-99..Macrophage #> PDK4                 1.635097             2.357126              1.22262 #> TNFRSF17             0.000000             0.000000              0.00000 #> ICAM3                0.000000             0.000000              0.00000 #> FAP                  0.000000             0.000000              0.00000 #> GZMB                 0.000000             1.541691              0.00000 #> TSC2                 0.000000             0.000000              0.00000 #>          X53_Y-99..Macrophage X50_Y-99..Macrophage X51_Y-99..Macrophage #> PDK4                        0            0.6707283                    0 #> TNFRSF17                    0            0.0000000                    0 #> ICAM3                       0            0.0000000                    0 #> FAP                         0            0.0000000                    0 #> GZMB                        0            0.0000000                    0 #> TSC2                        0            0.0000000                    0 #>          X50_Y-100..Macrophage X52_Y-100..Macrophage X54_Y-100..Macrophage #> PDK4                  0.975259                     0              1.766418 #> TNFRSF17              0.000000                     0              0.000000 #> ICAM3                 0.000000                     0              0.000000 #> FAP                   0.000000                     0              0.000000 #> GZMB                  0.000000                     0              0.000000 #> TSC2                  0.000000                     0              0.000000 #>          X49_Y-100..Macrophage X53_Y-100..Macrophage X51_Y-100..Macrophage #> PDK4                  1.201118              2.208022              2.685093 #> TNFRSF17              0.000000              0.000000              0.000000 #> ICAM3                 0.000000              0.000000              0.000000 #> FAP                   0.000000              0.000000              0.000000 #> GZMB                  0.000000              0.000000              0.000000 #> TSC2                  0.000000              0.000000              0.000000 #>          X50_Y-101..Macrophage X51_Y-101..Macrophage X49_Y-101..Macrophage #> PDK4                 0.0000000             0.9130059             0.2668444 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.0000000             0.0000000 #> GZMB                 0.6883303             0.0000000             0.5617099 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X52_Y-101..Macrophage X48_Y-101..Macrophage X50_Y-102..Macrophage #> PDK4                         0             0.4574475             0.3578855 #> TNFRSF17                     0             0.0000000             0.0000000 #> ICAM3                        0             0.0000000             0.0000000 #> FAP                          0             0.0000000             0.0000000 #> GZMB                         0             0.0000000             0.0000000 #> TSC2                         0             0.0000000             0.0000000 #>          X52_Y-102..Macrophage X49_Y-102..Macrophage X48_Y-102..Macrophage #> PDK4                  1.538374             0.4902589             0.3922071 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             0.0000000             0.0000000 #> GZMB                  0.000000             0.4566371             0.3653096 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X51_Y-102..Macrophage X50_Y-103..Macrophage X52_Y-103..Macrophage #> PDK4                         0             0.9064803              4.615121 #> TNFRSF17                     0             0.0000000              0.000000 #> ICAM3                        0             0.0000000              0.000000 #> FAP                          0             0.0000000              0.000000 #> GZMB                         0             0.0000000              0.000000 #> TSC2                         0             0.0000000              0.000000 #>          X53_Y-103..Macrophage X45_Y-97..Macrophage X47_Y-98..Macrophage #> PDK4                  1.361877             1.736759                    0 #> TNFRSF17              0.000000             0.000000                    0 #> ICAM3                 0.000000             0.000000                    0 #> FAP                   0.000000             0.000000                    0 #> GZMB                  0.000000             0.000000                    0 #> TSC2                  0.000000             0.000000                    0 #>          X45_Y-98..Macrophage X43_Y-98..Macrophage X46_Y-98..Macrophage #> PDK4                 1.530914                    0             0.000000 #> TNFRSF17             0.000000                    0             0.000000 #> ICAM3                0.000000                    0             0.000000 #> FAP                  0.000000                    0             0.000000 #> GZMB                 0.000000                    0             3.081452 #> TSC2                 0.000000                    0             0.000000 #>          X42_Y-99..Macrophage X44_Y-99..Macrophage X44_Y-100..Macrophage #> PDK4                        0            0.6990857             0.7512323 #> TNFRSF17                    0            0.0000000             0.0000000 #> ICAM3                       0            0.0000000             0.0000000 #> FAP                         0            0.0000000             0.0000000 #> GZMB                        0            0.0000000             0.0000000 #> TSC2                        0            0.0000000             0.0000000 #>          X45_Y-100..Macrophage X43_Y-100..Macrophage X46_Y-100..Macrophage #> PDK4                 0.3866215                     0              1.771166 #> TNFRSF17             0.0000000                     0              0.000000 #> ICAM3                0.0000000                     0              0.000000 #> FAP                  0.0000000                     0              0.000000 #> GZMB                 0.0000000                     0              0.000000 #> TSC2                 0.3866215                     0              0.000000 #>          X43_Y-101..Macrophage X47_Y-101..Macrophage X45_Y-101..Macrophage #> PDK4                         0              0.726275                     0 #> TNFRSF17                     0              0.000000                     0 #> ICAM3                        0              0.000000                     0 #> FAP                          0              0.000000                     0 #> GZMB                         0              0.000000                     0 #> TSC2                         0              0.000000                     0 #>          X42_Y-101..Macrophage X46_Y-101..Macrophage X47_Y-102..Macrophage #> PDK4                   1.81018              0.726275             0.6052292 #> TNFRSF17               0.00000              0.000000             0.0000000 #> ICAM3                  0.00000              0.000000             0.0000000 #> FAP                    0.00000              0.000000             0.0000000 #> GZMB                   0.00000              0.000000             0.0000000 #> TSC2                   0.00000              0.000000             0.0000000 #>          X46_Y-102..Macrophage X44_Y-102..Macrophage X47_Y-103..Macrophage #> PDK4                 0.6052292                     0              2.848167 #> TNFRSF17             0.0000000                     0              0.000000 #> ICAM3                0.0000000                     0              0.000000 #> FAP                  0.0000000                     0              0.000000 #> GZMB                 0.0000000                     0              0.000000 #> TSC2                 0.0000000                     0              0.000000 #>          X28_Y-96..NK X24_Y-96..NK X65_Y-93..NK X61_Y-93..NK X63_Y-91..NK #> PDK4                0     0.000000            0     0.000000     0.000000 #> TNFRSF17            0     0.000000            0     0.000000     0.000000 #> ICAM3               0     4.443047            0     2.940466     4.766567 #> FAP                 0     0.000000            0     0.000000     0.000000 #> GZMB                0     0.000000            0     0.000000     2.569343 #> TSC2                0     0.000000            0     0.000000     0.000000 #>          X63_Y-92..NK X62_Y-93..NK X59_Y-92..NK X60_Y-92..NK X57_Y-93..NK #> PDK4         0.000000            0     0.000000            0            0 #> TNFRSF17     0.000000            0     0.000000            0            0 #> ICAM3        4.968821            0     4.275582            0            0 #> FAP          0.000000            0     0.000000            0            0 #> GZMB         3.884015            0     0.000000            0            0 #> TSC2         0.000000            0     0.000000            0            0 #>          X58_Y-94..NK X59_Y-95..NK X60_Y-93..NK X56_Y-97..NK X77_Y-89..NK #> PDK4                0            0     0.000000      0.00000            0 #> TNFRSF17            0            0     0.000000      0.00000            0 #> ICAM3               0            0     4.933978      4.99761            0 #> FAP                 0            0     0.000000      0.00000            0 #> GZMB                0            0     0.000000      0.00000            0 #> TSC2                0            0     0.000000      0.00000            0 #>          X77_Y-90..NK X40_Y-72..NK X72_Y-75..NK X78_Y-75..NK X75_Y-78..NK #> PDK4         0.000000     0.000000     0.000000     0.000000     0.000000 #> TNFRSF17     0.000000     0.000000     0.000000     0.000000     0.000000 #> ICAM3        0.000000     4.676402     5.375527     0.000000     5.254763 #> FAP          0.000000     0.000000     0.000000     0.000000     0.000000 #> GZMB         2.450162     0.000000     0.000000     5.027264     0.000000 #> TSC2         0.000000     4.676402     0.000000     0.000000     0.000000 #>          X69_Y-75..NK X70_Y-76..NK X68_Y-74..NK X72_Y-74..NK X70_Y-75..NK #> PDK4         0.000000            0            0            0     0.000000 #> TNFRSF17     0.000000            0            0            0     0.000000 #> ICAM3        4.968821            0            0            0     2.815207 #> FAP          0.000000            0            0            0     0.000000 #> GZMB         4.968821            0            0            0     0.000000 #> TSC2         4.968821            0            0            0     0.000000 #>          X70_Y-78..NK X54_Y-79..NK X73_Y-68..NK X52_Y-74..NK X54_Y-78..NK #> PDK4                0     0.000000     0.000000            0     0.000000 #> TNFRSF17            0     0.000000     0.000000            0     0.000000 #> ICAM3               0     2.619282     5.333615            0     2.005977 #> FAP                 0     0.000000     0.000000            0     0.000000 #> GZMB                0     2.521017     4.645283            0     2.016813 #> TSC2                0     0.000000     0.000000            0     0.000000 #>          X48_Y-78..NK X49_Y-78..NK X49_Y-79..NK X48_Y-79..NK X53_Y-75..NK #> PDK4         0.000000     0.000000     0.000000            0            0 #> TNFRSF17     0.000000     0.000000     0.000000            0            0 #> ICAM3        2.264917     0.000000     1.151317            0            0 #> FAP          0.000000     0.000000     0.000000            0            0 #> GZMB         2.317563     1.158781     0.000000            0            0 #> TSC2         0.000000     0.000000     0.000000            0            0 #>          X53_Y-78..NK X43_Y-92..NK X44_Y-94..NK X46_Y-95..NK X44_Y-95..NK #> PDK4         0.000000     0.000000            0            0            0 #> TNFRSF17     0.000000     0.000000            0            0            0 #> ICAM3        2.437103     4.498574            0            0            0 #> FAP          0.000000     0.000000            0            0            0 #> GZMB         0.000000     0.000000            0            0            0 #> TSC2         0.000000     0.000000            0            0            0 #>          X42_Y-96..NK X48_Y-98..NK X45_Y-92..NK X46_Y-94..NK X47_Y-96..NK #> PDK4         0.000000            0            0            0     0.000000 #> TNFRSF17     0.000000            0            0            0     0.000000 #> ICAM3        4.123746            0            0            0     0.000000 #> FAP          0.000000            0            0            0     0.000000 #> GZMB         0.000000            0            0            0     4.538951 #> TSC2         0.000000            0            0            0     0.000000 #>          X22_Y-79..NK X54_Y-64..NK X49_Y-66..NK X51_Y-66..NK X43_Y-77..NK #> PDK4         0.000000            0     0.000000     0.000000     0.000000 #> TNFRSF17     0.000000            0     0.000000     0.000000     0.000000 #> ICAM3        0.000000            0     4.927154     0.000000     4.936263 #> FAP          0.000000            0     0.000000     0.000000     0.000000 #> GZMB         5.375527            0     0.000000     4.348158     0.000000 #> TSC2         0.000000            0     0.000000     0.000000     0.000000 #>          X47_Y-77..NK X47_Y-78..NK X75_Y-80..NK X76_Y-81..NK X77_Y-82..NK #> PDK4         0.000000     0.000000            0     0.000000     0.000000 #> TNFRSF17     0.000000     0.000000            0     0.000000     0.000000 #> ICAM3        2.477368     2.264917            0     4.753095     4.371029 #> FAP          0.000000     0.000000            0     0.000000     0.000000 #> GZMB         0.000000     0.000000            0     0.000000     0.000000 #> TSC2         0.000000     0.000000            0     0.000000     0.000000 #>          X73_Y-84..NK X77_Y-68..NK X74_Y-69..NK X73_Y-70..NK X74_Y-70..NK #> PDK4                0     0.000000     0.000000     0.000000     0.000000 #> TNFRSF17            0     0.000000     0.000000     0.000000     0.000000 #> ICAM3               0     4.635125     2.382278     4.605269     1.535090 #> FAP                 0     0.000000     0.000000     0.000000     0.000000 #> GZMB                0     0.000000     2.928734     5.697193     3.716875 #> TSC2                0     0.000000     0.000000     0.000000     1.661037 #>          X72_Y-72..NK X57_Y-67..NK X59_Y-70..NK X60_Y-68..NK X45_Y-80..NK #> PDK4         0.000000     0.000000     0.000000     0.000000     0.000000 #> TNFRSF17     0.000000     0.000000     0.000000     0.000000     0.000000 #> ICAM3        0.000000     4.296792     0.000000     0.000000     4.355722 #> FAP          0.000000     0.000000     0.000000     0.000000     0.000000 #> GZMB         4.459799     0.000000     3.847411     5.089387     0.000000 #> TSC2         0.000000     0.000000     0.000000     0.000000     4.355722 #>          X43_Y-84..NK X46_Y-81..NK X46_Y-82..NK X49_Y-91..NK X53_Y-91..NK #> PDK4         0.000000            0     0.000000     0.000000            0 #> TNFRSF17     0.000000            0     0.000000     0.000000            0 #> ICAM3        4.811788            0     5.164289     2.979880            0 #> FAP          0.000000            0     0.000000     0.000000            0 #> GZMB         4.811788            0     0.000000     1.525432            0 #> TSC2         0.000000            0     0.000000     0.000000            0 #>          X54_Y-92..NK X72_Y-83..NK X71_Y-79..NK X67_Y-84..NK X68_Y-85..NK #> PDK4         0.000000     0.000000     0.000000            0     0.000000 #> TNFRSF17     0.000000     0.000000     0.000000            0     0.000000 #> ICAM3        4.641464     3.992524     4.753095            0     1.322255 #> FAP          0.000000     0.000000     0.000000            0     0.000000 #> GZMB         0.000000     0.000000     0.000000            0     3.124978 #> TSC2         0.000000     0.000000     0.000000            0     1.439492 #>          X64_Y-65..NK X56_Y-80..NK X54_Y-81..NK X55_Y-81..NK X58_Y-81..NK #> PDK4         0.000000            0     0.000000            0     0.000000 #> TNFRSF17     0.000000            0     0.000000            0     0.000000 #> ICAM3        0.000000            0     1.495159            0     2.421251 #> FAP          0.000000            0     0.000000            0     0.000000 #> GZMB         0.000000            0     1.724324            0     0.000000 #> TSC2         5.012325            0     0.000000            0     0.000000 #>          X58_Y-82..NK X54_Y-82..NK X56_Y-82..NK X62_Y-83..NK X61_Y-84..NK #> PDK4         0.000000     0.000000     0.000000     0.000000     0.000000 #> TNFRSF17     0.000000     0.000000     0.000000     0.000000     0.000000 #> ICAM3        2.536743     5.333615     4.782003     4.878511     2.439255 #> FAP          0.000000     0.000000     0.000000     0.000000     0.000000 #> GZMB         0.000000     4.645283     4.097200     0.000000     0.000000 #> TSC2         0.000000     0.000000     0.000000     0.000000     0.000000 #>          X64_Y-84..NK X63_Y-84..NK X65_Y-84..NK X63_Y-85..NK X45_Y-85..NK #> PDK4         0.000000     0.000000     0.000000     0.000000     0.000000 #> TNFRSF17     0.000000     0.000000     0.000000     0.000000     0.000000 #> ICAM3        0.000000     2.332959     4.787888     2.498805     0.000000 #> FAP          0.000000     0.000000     0.000000     0.000000     0.000000 #> GZMB         4.861401     0.000000     0.000000     0.000000     4.085632 #> TSC2         0.000000     0.000000     0.000000     0.000000     0.000000 #>          X45_Y-86..NK X47_Y-89..NK X48_Y-90..NK X45_Y-90..NK X44_Y-91..NK #> PDK4                0     0.000000            0     0.000000            0 #> TNFRSF17            0     0.000000            0     0.000000            0 #> ICAM3               0     4.848761            0     5.500860            0 #> FAP                 0     0.000000            0     0.000000            0 #> GZMB                0     0.000000            0     0.000000            0 #> TSC2                0     0.000000            0     4.126741            0 #>          X48_Y-89..NK X45_Y-91..NK X50_Y-80..NK X53_Y-81..NK X54_Y-80..NK #> PDK4          0.00000            0     0.000000     0.000000     0.000000 #> TNFRSF17      0.00000            0     0.000000     0.000000     0.000000 #> ICAM3         5.33045            0     1.651578     4.811788     5.147937 #> FAP           0.00000            0     0.000000     0.000000     0.000000 #> GZMB          0.00000            0     1.584365     4.126741     3.111700 #> TSC2          0.00000            0     0.000000     0.000000     0.000000 #>          X52_Y-80..NK X52_Y-84..NK X70_Y-96..NK X74_Y-93..NK X75_Y-95..NK #> PDK4         0.000000     0.000000     0.000000            0     0.000000 #> TNFRSF17     0.000000     0.000000     0.000000            0     0.000000 #> ICAM3        4.741765     5.190573     0.000000            0     2.443589 #> FAP          0.000000     0.000000     0.000000            0     0.000000 #> GZMB         0.000000     0.000000     4.887178            0     2.540702 #> TSC2         0.000000     0.000000     0.000000            0     0.000000 #>          X78_Y-96..NK X76_Y-94..NK X78_Y-95..NK X46_Y-67..NK X46_Y-71..NK #> PDK4                0            0            0     0.000000     0.000000 #> TNFRSF17            0            0            0     0.000000     0.000000 #> ICAM3               0            0            0     3.956653     4.576296 #> FAP                 0            0            0     0.000000     0.000000 #> GZMB                0            0            0     0.000000     0.000000 #> TSC2                0            0            0     0.000000     0.000000 #>          X47_Y-72..NK X74_Y-66..NK X74_Y-65..NK X30_Y-102..NK X33_Y-104..NK #> PDK4         0.000000     0.000000            0      0.000000             0 #> TNFRSF17     0.000000     0.000000            0      0.000000             0 #> ICAM3        4.182296     4.426577            0      5.217575             0 #> FAP          0.000000     0.000000            0      0.000000             0 #> GZMB         4.182296     5.113729            0      0.000000             0 #> TSC2         0.000000     0.000000            0      0.000000             0 #>          X28_Y-101..NK X74_Y-106..NK X64_Y-99..NK X65_Y-101..NK X62_Y-101..NK #> PDK4                 0      0.000000     0.000000      0.000000      0.000000 #> TNFRSF17             0      0.000000     0.000000      0.000000      0.000000 #> ICAM3                0      2.354270     0.000000      2.137791      2.307560 #> FAP                  0      0.000000     0.000000      0.000000      0.000000 #> GZMB                 0      2.302635     4.874205      2.418141      2.411979 #> TSC2                 0      0.000000     0.000000      0.000000      0.000000 #>          X63_Y-100..NK X63_Y-101..NK X66_Y-101..NK X64_Y-103..NK X67_Y-85..NK #> PDK4                 0             0      0.000000             0     0.000000 #> TNFRSF17             0             0      0.000000             0     0.000000 #> ICAM3                0             0      2.137791             0     3.966766 #> FAP                  0             0      0.000000             0     0.000000 #> GZMB                 0             0      2.418141             0     3.966766 #> TSC2                 0             0      0.000000             0     0.000000 #>          X67_Y-87..NK X67_Y-88..NK X69_Y-88..NK X69_Y-85..NK X72_Y-101..NK #> PDK4         0.000000     0.000000     0.000000     0.000000      0.000000 #> TNFRSF17     0.000000     0.000000     0.000000     0.000000      0.000000 #> ICAM3        4.684526     4.830101     2.666807     4.753095      5.863282 #> FAP          0.000000     0.000000     0.000000     0.000000      0.000000 #> GZMB         2.072454     4.144908     2.322641     0.000000      0.000000 #> TSC2         0.000000     0.000000     0.000000     0.000000      0.000000 #>          X67_Y-104..NK X71_Y-105..NK X68_Y-106..NK X66_Y-104..NK X56_Y-99..NK #> PDK4          0.000000      0.000000             0             0     0.000000 #> TNFRSF17      0.000000      0.000000             0             0     0.000000 #> ICAM3         0.000000      2.399883             0             0     2.430701 #> FAP           0.000000      0.000000             0             0     0.000000 #> GZMB          4.363345      0.000000             0             0     0.000000 #> TSC2          0.000000      0.000000             0             0     0.000000 #>          X56_Y-98..NK X55_Y-99..NK X58_Y-99..NK X41_Y-98..NK X42_Y-98..NK #> PDK4                0            0     0.000000     0.000000     0.000000 #> TNFRSF17            0            0     0.000000     0.000000     0.000000 #> ICAM3               0            0     5.254133     4.848761     4.635125 #> FAP                 0            0     0.000000     0.000000     0.000000 #> GZMB                0            0     0.000000     0.000000     0.000000 #> TSC2                0            0     0.000000     0.000000     0.000000 #>          X42_Y-99..NK X41_Y-102..NK X41_Y-103..NK X42_Y-103..NK X62_Y-85..NK #> PDK4         0.000000      0.000000      0.000000      0.000000            0 #> TNFRSF17     0.000000      0.000000      0.000000      0.000000            0 #> ICAM3        5.779448      3.051758      1.525879      0.000000            0 #> FAP          0.000000      0.000000      0.000000      0.000000            0 #> GZMB         0.000000      0.000000      1.158781      2.443589            0 #> TSC2         0.000000      0.000000      0.000000      0.000000            0 #>          X63_Y-86..NK X65_Y-86..NK X66_Y-86..NK X62_Y-90..NK X61_Y-91..NK #> PDK4         0.000000     0.000000            0     0.000000     0.000000 #> TNFRSF17     0.000000     0.000000            0     0.000000     0.000000 #> ICAM3        5.091651     2.651652            0     4.576296     4.355722 #> FAP          0.000000     0.000000            0     0.000000     0.000000 #> GZMB         0.000000     0.000000            0     0.000000     0.000000 #> TSC2         0.000000     0.000000            0     4.576296     0.000000 #>          X64_Y-85..NK X64_Y-89..NK X63_Y-90..NK X64_Y-90..NK X39_Y-94..NK #> PDK4         0.000000            0     0.000000     0.000000     0.000000 #> TNFRSF17     0.000000            0     0.000000     0.000000     0.000000 #> ICAM3        5.376614            0     4.497371     4.625072     4.848761 #> FAP          0.000000            0     0.000000     0.000000     0.000000 #> GZMB         0.000000            0     0.000000     0.000000     0.000000 #> TSC2         0.000000            0     2.288148     0.000000     0.000000 #>          X41_Y-104..NK X40_Y-105..NK X53_Y-88..NK X54_Y-89..NK X48_Y-91..NK #> PDK4          0.000000      0.000000     0.000000     0.000000     0.000000 #> TNFRSF17      0.000000      0.000000     0.000000     0.000000     0.000000 #> ICAM3         2.370883      4.861401     3.606646     3.951636     4.363345 #> FAP           0.000000      0.000000     0.000000     0.000000     0.000000 #> GZMB          2.045700      0.000000     0.000000     0.000000     0.000000 #> TSC2          0.000000      0.000000     0.000000     3.951636     0.000000 #>          X51_Y-88..NK X52_Y-89..NK X54_Y-90..NK X52_Y-91..NK X59_Y-91..NK #> PDK4         0.000000     0.000000            0            0     0.000000 #> TNFRSF17     0.000000     0.000000            0            0     0.000000 #> ICAM3        2.430701     2.495167            0            0     0.000000 #> FAP          0.000000     0.000000            0            0     0.000000 #> GZMB         2.430701     0.000000            0            0     4.906964 #> TSC2         0.000000     0.000000            0            0     0.000000 #>          X58_Y-90..NK X55_Y-65..NK X51_Y-100..NK X52_Y-100..NK X49_Y-101..NK #> PDK4                0            0      0.000000      0.000000             0 #> TNFRSF17            0            0      0.000000      0.000000             0 #> ICAM3               0            0      5.081404      4.538951             0 #> FAP                 0            0      0.000000      0.000000             0 #> GZMB                0            0      5.081404      3.856432             0 #> TSC2                0            0      0.000000      0.000000             0 #>          X51_Y-99..NK X43_Y-98..NK X42_Y-101..NK X24_Y-97..Plasma #> PDK4         0.000000       0.0000             0        0.7659193 #> TNFRSF17     0.000000       0.0000             0        0.0000000 #> ICAM3        2.540702       4.5208             0        3.2833320 #> FAP          0.000000       0.0000             0        0.0000000 #> GZMB         4.506615       0.0000             0        0.0000000 #> TSC2         0.000000       0.0000             0        0.0000000 #>          X25_Y-97..Plasma X62_Y-91..Plasma X61_Y-92..Plasma X61_Y-93..Plasma #> PDK4             0.000000         0.000000         0.000000         0.000000 #> TNFRSF17         0.000000         1.260778         1.457010         0.000000 #> ICAM3            3.543635         3.096538         1.457010         0.000000 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             0.000000         4.815342         3.626032         1.588185 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X64_Y-93..Plasma X60_Y-97..Plasma X64_Y-92..Plasma X63_Y-93..Plasma #> PDK4            0.8970955         0.000000         0.000000         0.000000 #> TNFRSF17        0.8607933         4.451387         4.451387         1.075992 #> ICAM3           1.6896404         0.000000         4.451387         2.112051 #> FAP             0.0000000         0.000000         0.000000         0.000000 #> GZMB            2.9090172         4.451387         4.451387         2.343028 #> TSC2            0.0000000         0.000000         0.000000         0.000000 #>          X58_Y-91..Plasma X57_Y-92..Plasma X60_Y-92..Plasma X60_Y-93..Plasma #> PDK4             0.000000          0.00000         0.000000         5.042432 #> TNFRSF17         4.407790          0.00000         0.000000         0.000000 #> ICAM3            2.470424          4.69771         4.836282         0.000000 #> FAP              0.000000          0.00000         0.000000         0.000000 #> GZMB             5.098250          0.00000         0.000000         5.732345 #> TSC2             0.000000          0.00000         0.000000         0.000000 #>          X56_Y-94..Plasma X57_Y-95..Plasma X59_Y-97..Plasma X60_Y-91..Plasma #> PDK4             0.000000         0.000000         4.468283         0.000000 #> TNFRSF17         0.000000         0.000000         0.000000         5.097434 #> ICAM3            0.000000         0.000000         0.000000         0.000000 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             6.329721         5.768786         6.250441         0.000000 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X57_Y-91..Plasma X55_Y-93..Plasma X57_Y-97..Plasma X73_Y-73..Plasma #> PDK4            0.8048740                0         0.000000         0.000000 #> TNFRSF17        2.6532827                0         0.000000         0.000000 #> ICAM3           2.9907500                0         0.000000         2.905183 #> FAP             0.0000000                0         0.000000         0.000000 #> GZMB            0.8788898                0         5.181734         2.076290 #> TSC2            0.0000000                0         0.000000         0.000000 #>          X73_Y-74..Plasma X75_Y-78..Plasma X61_Y-69..Plasma X62_Y-69..Plasma #> PDK4             0.000000         0.000000                0         0.000000 #> TNFRSF17         2.544693         4.172813                0         1.898395 #> ICAM3            2.595287         4.573129                0         0.000000 #> FAP              0.000000         0.000000                0         0.000000 #> GZMB             2.595287         0.000000                0         0.000000 #> TSC2             0.000000         0.000000                0         0.000000 #>          X62_Y-70..Plasma X63_Y-72..Plasma X64_Y-73..Plasma X65_Y-73..Plasma #> PDK4             0.000000         0.000000         0.000000         0.000000 #> TNFRSF17         3.163992         4.933978         1.987211         1.324807 #> ICAM3            0.000000         0.000000         4.142808         4.229333 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             0.000000         0.000000         0.000000         0.000000 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X66_Y-73..Plasma X65_Y-74..Plasma X66_Y-77..Plasma X65_Y-75..Plasma #> PDK4             0.000000         0.000000                0                0 #> TNFRSF17         0.000000         0.000000                0                0 #> ICAM3            4.402383         4.566825                0                0 #> FAP              0.000000         0.000000                0                0 #> GZMB             0.000000         0.000000                0                0 #> TSC2             0.000000         0.000000                0                0 #>          X72_Y-73..Plasma X72_Y-74..Plasma X72_Y-75..Plasma X70_Y-76..Plasma #> PDK4             0.000000         0.000000         2.302635         2.213289 #> TNFRSF17         1.919237         2.723893         2.166602         2.213289 #> ICAM3            4.735393         4.815469         2.166602         2.556864 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             5.080242         3.237124         2.992018         5.750529 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X71_Y-77..Plasma X71_Y-78..Plasma X70_Y-78..Plasma X71_Y-79..Plasma #> PDK4             0.000000        2.4002148         1.366269         2.067891 #> TNFRSF17         0.000000        0.9757137         0.000000         1.993658 #> ICAM3            2.393944        1.1969721         2.176280         2.335573 #> FAP              0.000000        0.0000000         0.000000         0.000000 #> GZMB             3.083958        5.2610635         4.213001         2.067891 #> TSC2             0.000000        0.0000000         0.000000         0.000000 #>          X68_Y-74..Plasma X71_Y-75..Plasma X71_Y-76..Plasma X69_Y-76..Plasma #> PDK4             0.000000         0.000000         0.000000         4.426577 #> TNFRSF17         4.730565         0.000000         2.357619         4.426577 #> ICAM3            0.000000         0.000000         0.000000         5.113729 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             6.332920         5.687374         2.615437         5.803865 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X54_Y-77..Plasma X54_Y-78..Plasma X54_Y-76..Plasma X55_Y-78..Plasma #> PDK4             0.000000         0.000000         0.000000         0.000000 #> TNFRSF17         2.244912         1.039303         2.244912         0.000000 #> ICAM3            4.562474         3.492219         4.562474         2.528918 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             0.000000         2.746863         0.000000         5.125980 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X73_Y-66..Plasma X73_Y-67..Plasma X72_Y-70..Plasma X52_Y-72..Plasma #> PDK4            2.1964522        1.5116341         0.000000         4.443047 #> TNFRSF17        0.7611375        0.7611375         0.000000         4.443047 #> ICAM3           1.4789108        1.5734930         3.982138         5.130296 #> FAP             0.0000000        0.0000000         0.000000         0.000000 #> GZMB            2.5003687        3.5193911         0.000000         0.000000 #> TSC2            0.0000000        0.0000000         0.000000         0.000000 #>          X52_Y-73..Plasma X51_Y-73..Plasma X53_Y-74..Plasma X53_Y-75..Plasma #> PDK4            0.7405078        0.0000000         1.137039         0.000000 #> TNFRSF17        2.1592989        0.9805178         2.200745         0.000000 #> ICAM3           2.2658942        1.1393614         3.854028         4.787888 #> FAP             0.0000000        0.0000000         0.000000         0.000000 #> GZMB            0.9415068        1.4122602         0.000000         0.000000 #> TSC2            0.0000000        0.0000000         0.000000         0.000000 #>          X53_Y-78..Plasma X48_Y-78..Plasma X49_Y-79..Plasma X53_Y-79..Plasma #> PDK4             0.000000         1.278012         0.000000         1.658029 #> TNFRSF17         2.078606         1.635655         1.917019         1.090095 #> ICAM3            2.421251         1.635655         4.528472         2.838103 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             2.437103         0.000000         0.000000         5.115705 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X54_Y-79..Plasma X51_Y-78..Plasma X43_Y-91..Plasma X44_Y-91..Plasma #> PDK4             1.011567          0.00000         0.000000         1.256611 #> TNFRSF17         0.927025          0.00000         0.000000         1.256611 #> ICAM3            2.762744          6.20011         3.502503         4.866456 #> FAP              0.000000          0.00000         0.000000         0.000000 #> GZMB             5.993564          0.00000         2.161650         1.701849 #> TSC2             0.000000          0.00000         0.000000         0.000000 #>          X47_Y-91..Plasma X45_Y-91..Plasma X44_Y-92..Plasma X42_Y-92..Plasma #> PDK4             3.016933         0.000000         0.000000         0.000000 #> TNFRSF17         0.000000         0.000000         0.000000         3.745314 #> ICAM3            1.823651         3.604595         4.823959         5.517187 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             1.876805         0.000000         0.000000         0.000000 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X45_Y-92..Plasma X46_Y-93..Plasma X45_Y-94..Plasma X44_Y-95..Plasma #> PDK4             0.000000         0.000000         0.000000         0.000000 #> TNFRSF17         0.000000         4.997610         0.000000         2.162906 #> ICAM3            4.696098         3.912415         2.403882         4.505042 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             0.000000         0.000000         2.897830         1.998880 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X45_Y-97..Plasma X44_Y-97..Plasma X47_Y-98..Plasma X46_Y-92..Plasma #> PDK4             0.000000         0.000000         0.000000         2.255925 #> TNFRSF17         4.029781         1.961036         0.000000         0.000000 #> ICAM3            5.116471         2.302635         4.378773         2.170326 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             4.029781         0.000000         0.000000         0.000000 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X46_Y-94..Plasma X46_Y-95..Plasma X23_Y-79..Plasma X47_Y-66..Plasma #> PDK4             0.000000         1.472815         0.000000         0.000000 #> TNFRSF17         2.498805         0.000000         0.000000         1.411500 #> ICAM3            1.956208         0.000000         4.664183         3.561119 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             2.936917         5.930443         0.000000         0.000000 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X52_Y-65..Plasma X51_Y-66..Plasma X51_Y-67..Plasma X36_Y-83..Plasma #> PDK4             0.000000        1.6435318        1.5094846         2.440335 #> TNFRSF17         0.000000        0.9839354        0.9294496         0.000000 #> ICAM3            4.108909        3.6228577        4.5148009         4.765536 #> FAP              0.000000        0.0000000        0.0000000         0.000000 #> GZMB             0.000000        0.0000000        0.0000000         0.000000 #> TSC2             0.000000        0.0000000        0.0000000         0.000000 #>          X36_Y-84..Plasma X37_Y-84..Plasma X41_Y-84..Plasma X39_Y-84..Plasma #> PDK4             1.626890         1.670511         0.000000         3.642174 #> TNFRSF17         1.552997         4.880914         0.000000         0.000000 #> ICAM3            4.899030         4.933213         5.484797         0.000000 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             0.000000         0.000000         0.000000         0.000000 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X47_Y-74..Plasma X47_Y-76..Plasma X46_Y-76..Plasma X42_Y-76..Plasma #> PDK4                    0        0.5555272        0.0000000         1.632668 #> TNFRSF17                0        3.5803102        2.6348229         2.169081 #> ICAM3                   0        1.1933545        0.7259537         0.000000 #> FAP                     0        0.0000000        0.0000000         0.000000 #> GZMB                    0        1.3589303        0.7564919         0.000000 #> TSC2                    0        0.0000000        0.0000000         0.000000 #>          X44_Y-76..Plasma X46_Y-77..Plasma X43_Y-77..Plasma X48_Y-77..Plasma #> PDK4             0.000000         0.000000          0.00000         3.834037 #> TNFRSF17         2.113910         0.000000          4.38658         0.000000 #> ICAM3            2.456824         5.235994          4.38658         0.000000 #> FAP              0.000000         0.000000          0.00000         0.000000 #> GZMB             0.000000         6.149087          0.00000         0.000000 #> TSC2             0.000000         0.000000          0.00000         0.000000 #>          X46_Y-78..Plasma X47_Y-75..Plasma X45_Y-78..Plasma X47_Y-78..Plasma #> PDK4             0.000000         0.000000         2.274077         1.573163 #> TNFRSF17         2.815903         2.340843         4.741066         1.358067 #> ICAM3            1.675755         4.093215         0.000000         1.358067 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             1.644659         0.000000         5.084986         5.242215 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X75_Y-80..Plasma X77_Y-82..Plasma X75_Y-81..Plasma X74_Y-67..Plasma #> PDK4             0.000000         0.000000                0         1.153780 #> TNFRSF17         1.252499         0.000000                0         0.000000 #> ICAM3            3.145313         5.121978                0         0.000000 #> FAP              0.000000         0.000000                0         0.000000 #> GZMB             0.000000         4.035223                0         4.351288 #> TSC2             0.000000         0.000000                0         0.000000 #>          X75_Y-69..Plasma X77_Y-69..Plasma X74_Y-69..Plasma X75_Y-70..Plasma #> PDK4             0.000000                0         0.000000         0.000000 #> TNFRSF17         0.000000                0         2.107297         0.000000 #> ICAM3            4.638294                0         2.450162         0.000000 #> FAP              0.000000                0         0.000000         0.000000 #> GZMB             0.000000                0         2.762726         6.558517 #> TSC2             0.000000                0         0.000000         0.000000 #>          X73_Y-71..Plasma X77_Y-72..Plasma X73_Y-68..Plasma X75_Y-68..Plasma #> PDK4             0.000000         2.174079         0.000000         0.000000 #> TNFRSF17         0.000000         0.000000         0.000000         0.000000 #> ICAM3            4.394449         2.151983         4.676402         4.638294 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             5.484797         3.208110         4.676402         0.000000 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X74_Y-70..Plasma X57_Y-67..Plasma X42_Y-79..Plasma X46_Y-79..Plasma #> PDK4             0.000000         0.000000                0         0.000000 #> TNFRSF17         2.107297         4.736149                0         0.000000 #> ICAM3            4.706087         5.138686                0         1.675755 #> FAP              0.000000         0.000000                0         0.000000 #> GZMB             2.599746         0.000000                0         1.651578 #> TSC2             0.000000         0.000000                0         0.000000 #>          X46_Y-80..Plasma X44_Y-81..Plasma X46_Y-81..Plasma X44_Y-82..Plasma #> PDK4             0.000000        0.3961891         0.000000         0.000000 #> TNFRSF17         0.000000        1.8576300         0.000000         1.978598 #> ICAM3            2.801558        3.8779574         4.958234         3.117699 #> FAP              0.000000        0.0000000         0.000000         0.000000 #> GZMB             2.477368        1.0614453         0.000000         1.161252 #> TSC2             0.000000        0.0000000         0.000000         0.000000 #>          X43_Y-82..Plasma X46_Y-82..Plasma X43_Y-83..Plasma X44_Y-83..Plasma #> PDK4            0.2973873         0.000000        0.5832398         0.000000 #> TNFRSF17        2.5923189         0.000000        2.4724216         1.893269 #> ICAM3           2.8830524         2.327773        3.5269782         2.234142 #> FAP             0.0000000         0.000000        0.0000000         0.000000 #> GZMB            0.6543168         0.000000        0.6992725         0.000000 #> TSC2            0.0000000         0.000000        0.0000000         0.000000 #>          X45_Y-83..Plasma X43_Y-84..Plasma X42_Y-84..Plasma X44_Y-84..Plasma #> PDK4                    0        0.0000000         0.000000         0.000000 #> TNFRSF17                0        0.8289816         1.036227         1.893269 #> ICAM3                   0        3.9481009         2.482558         4.732947 #> FAP                     0        0.0000000         0.000000         0.000000 #> GZMB                    0        2.2768812         2.544201         2.843687 #> TSC2                    0        0.0000000         0.000000         0.000000 #>          X51_Y-91..Plasma X53_Y-91..Plasma X54_Y-92..Plasma X72_Y-81..Plasma #> PDK4             0.000000         0.000000         0.000000         0.000000 #> TNFRSF17         0.000000         5.178805         2.590867         2.283413 #> ICAM3            4.513161         0.000000         0.000000         2.283413 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             0.000000         0.000000         2.873900         2.972648 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X71_Y-83..Plasma X70_Y-84..Plasma X70_Y-85..Plasma X68_Y-84..Plasma #> PDK4             0.000000         0.000000         0.000000         0.000000 #> TNFRSF17         0.000000         0.000000         0.000000         0.000000 #> ICAM3            4.091399         2.791581         4.248003         0.000000 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             4.091399         3.466558         5.623519         6.007351 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X50_Y-67..Plasma X50_Y-68..Plasma X52_Y-67..Plasma X50_Y-69..Plasma #> PDK4            0.6432827        0.0000000         3.931826        0.0000000 #> TNFRSF17        1.1250500        1.6869649         0.000000        1.8601075 #> ICAM3           4.7758792        3.6418106         0.000000        2.0625385 #> FAP             0.0000000        0.0000000         0.000000        0.0000000 #> GZMB            0.0000000        0.4829716         0.000000        0.8351343 #> TSC2            0.0000000        0.0000000         0.000000        0.0000000 #>          X51_Y-69..Plasma X49_Y-69..Plasma X49_Y-70..Plasma X50_Y-70..Plasma #> PDK4                    0        0.6662932        0.7995518         0.000000 #> TNFRSF17                0        2.4005132        1.9495066         0.000000 #> ICAM3                   0        3.2122588        2.9236013         1.432264 #> FAP                     0        0.0000000        0.0000000         0.000000 #> GZMB                    0        1.9326653        2.3191984         3.380911 #> TSC2                    0        0.0000000        0.0000000         0.000000 #>          X48_Y-71..Plasma X54_Y-80..Plasma X56_Y-80..Plasma X55_Y-80..Plasma #> PDK4             0.000000        0.0000000         0.000000        0.6725372 #> TNFRSF17         0.000000        0.0000000         0.000000        0.8711236 #> ICAM3            3.186339        0.8211924         6.021605        2.4746974 #> FAP              0.000000        0.0000000         0.000000        0.0000000 #> GZMB             0.000000        4.8457183         0.000000        1.0202493 #> TSC2             0.000000        0.0000000         0.000000        0.0000000 #>          X57_Y-80..Plasma X55_Y-81..Plasma X57_Y-81..Plasma X58_Y-81..Plasma #> PDK4             0.000000                0         0.000000         0.000000 #> TNFRSF17         0.000000                0         0.000000         0.000000 #> ICAM3            6.021605                0         4.459799         2.229899 #> FAP              0.000000                0         0.000000         0.000000 #> GZMB             0.000000                0         0.000000         0.000000 #> TSC2             0.000000                0         0.000000         0.000000 #>          X60_Y-81..Plasma X56_Y-82..Plasma X54_Y-83..Plasma X62_Y-84..Plasma #> PDK4              2.19329         0.000000                0         0.000000 #> TNFRSF17          0.00000         0.000000                0         0.000000 #> ICAM3             2.19329         5.155681                0         5.121978 #> FAP               0.00000         0.000000                0         0.000000 #> GZMB              0.00000         6.537641                0         4.434777 #> TSC2              0.00000         0.000000                0         0.000000 #>          X66_Y-84..Plasma X63_Y-85..Plasma X64_Y-84..Plasma X35_Y-97..Plasma #> PDK4             0.000000         1.748445         0.000000         0.000000 #> TNFRSF17         0.000000         1.457010         0.000000         3.411989 #> ICAM3            0.000000         3.378865         4.538951         4.994693 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             4.758809         0.000000         0.000000         0.000000 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X35_Y-93..Plasma X44_Y-86..Plasma X46_Y-88..Plasma X47_Y-88..Plasma #> PDK4             0.000000                0         4.378773         0.000000 #> TNFRSF17         0.000000                0         0.000000         3.059035 #> ICAM3            0.000000                0         4.378773         4.692837 #> FAP              0.000000                0         0.000000         0.000000 #> GZMB             5.408168                0         0.000000         0.000000 #> TSC2             0.000000                0         0.000000         0.000000 #>          X47_Y-89..Plasma X46_Y-89..Plasma X45_Y-89..Plasma X48_Y-90..Plasma #> PDK4            1.0255737        0.6427387         0.000000         0.000000 #> TNFRSF17        1.0098663        0.5617318         0.000000         1.930487 #> ICAM3           4.2172420        4.7234613         3.585953         2.155597 #> FAP             0.0000000        0.0000000         0.000000         0.000000 #> GZMB            0.6125405        0.8167207         4.665919         0.000000 #> TSC2            0.0000000        0.0000000         0.000000         0.000000 #>          X42_Y-90..Plasma X42_Y-91..Plasma X45_Y-87..Plasma X46_Y-91..Plasma #> PDK4             4.623797         0.000000         0.000000         2.255925 #> TNFRSF17         0.000000         0.000000         0.000000         0.000000 #> ICAM3            0.000000         0.000000         0.000000         0.000000 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             2.396905         6.555007         6.112466         0.000000 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X50_Y-79..Plasma X52_Y-79..Plasma X48_Y-79..Plasma X51_Y-79..Plasma #> PDK4             1.350579         3.976987         1.167058         0.000000 #> TNFRSF17         3.125048         0.000000         2.802712         1.064682 #> ICAM3            3.636566         3.976987         2.802712         2.792613 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             0.000000         6.357697         0.000000         0.000000 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X51_Y-80..Plasma X53_Y-80..Plasma X52_Y-80..Plasma X53_Y-81..Plasma #> PDK4              0.00000         1.030190                0         0.000000 #> TNFRSF17          0.00000         0.000000                0         1.363800 #> ICAM3             2.82609         1.030190                0         1.592051 #> FAP               0.00000         0.000000                0         0.000000 #> GZMB              0.00000         3.004239                0         0.000000 #> TSC2              0.00000         0.000000                0         0.000000 #>          X53_Y-82..Plasma X51_Y-82..Plasma X51_Y-83..Plasma X52_Y-83..Plasma #> PDK4             1.475526         1.661401        0.9105434        0.9105434 #> TNFRSF17         1.363800         0.000000        2.2128223        3.4188119 #> ICAM3            3.431114         1.661401        3.2933564        4.7726564 #> FAP              0.000000         0.000000        0.0000000        0.0000000 #> GZMB             0.000000         0.000000        1.3913437        1.3913437 #> TSC2             0.000000         0.000000        0.0000000        0.0000000 #>          X51_Y-84..Plasma X52_Y-84..Plasma X52_Y-85..Plasma X50_Y-83..Plasma #> PDK4             0.000000         0.000000        0.5078645         0.000000 #> TNFRSF17         1.864656         1.607986        1.8438383         0.000000 #> ICAM3            4.666213         3.840105        3.6759196         2.586486 #> FAP              0.000000         0.000000        0.0000000         0.000000 #> GZMB             0.000000         0.000000        0.6580076         0.000000 #> TSC2             0.000000         0.000000        0.0000000         0.000000 #>          X69_Y-92..Plasma X77_Y-93..Plasma X77_Y-96..Plasma X74_Y-95..Plasma #> PDK4             0.000000         0.000000         0.000000         0.000000 #> TNFRSF17         0.000000         0.000000         4.525306         4.557445 #> ICAM3            0.000000         4.175964         4.927154         0.000000 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             6.726633         6.241874         0.000000         5.649041 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X48_Y-69..Plasma X46_Y-68..Plasma X48_Y-70..Plasma X47_Y-71..Plasma #> PDK4             0.000000                0                0         0.000000 #> TNFRSF17         0.000000                0                0         0.000000 #> ICAM3            4.832157                0                0         2.255925 #> FAP              0.000000                0                0         0.000000 #> GZMB             3.749358                0                0         0.000000 #> TSC2             0.000000                0                0         0.000000 #>          X47_Y-72..Plasma X73_Y-65..Plasma X34_Y-90..Plasma X35_Y-90..Plasma #> PDK4             0.000000         0.000000         0.000000         0.000000 #> TNFRSF17         5.658486         2.069407         0.000000         0.000000 #> ICAM3            0.000000         2.069407         3.786538         0.000000 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             0.000000         0.000000         4.869919         6.775366 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X35_Y-91..Plasma X41_Y-89..Plasma X39_Y-91..Plasma X30_Y-101..Plasma #> PDK4             0.000000         0.000000                0          5.057837 #> TNFRSF17         0.000000         1.692026                0          0.000000 #> ICAM3            2.292929         0.000000                0          0.000000 #> FAP              0.000000         0.000000                0          0.000000 #> GZMB             0.000000         0.000000                0          0.000000 #> TSC2             0.000000         0.000000                0          0.000000 #>          X33_Y-103..Plasma X32_Y-103..Plasma X27_Y-101..Plasma #> PDK4              0.000000          0.000000           0.00000 #> TNFRSF17          1.141706          0.000000           0.00000 #> ICAM3             0.000000          0.000000           2.73059 #> FAP               0.000000          0.000000           0.00000 #> GZMB              3.257506          4.343342           0.00000 #> TSC2              0.000000          0.000000           0.00000 #>          X27_Y-102..Plasma X29_Y-102..Plasma X74_Y-105..Plasma #> PDK4               0.00000          0.000000          0.000000 #> TNFRSF17           0.00000          3.620698          0.000000 #> ICAM3              2.73059          4.701306          0.000000 #> FAP                0.00000          0.000000          0.000000 #> GZMB               0.00000          4.701306          6.621406 #> TSC2               0.00000          0.000000          0.000000 #>          X74_Y-106..Plasma X61_Y-99..Plasma X61_Y-100..Plasma X63_Y-101..Plasma #> PDK4              0.000000          0.00000          4.836282          0.000000 #> TNFRSF17          4.730565          0.00000          0.000000          0.000000 #> ICAM3             0.000000          0.00000          4.836282          0.000000 #> FAP               0.000000          0.00000          0.000000          0.000000 #> GZMB              5.419291          6.15001          6.908755          5.832549 #> TSC2              0.000000          0.00000          0.000000          0.000000 #>          X66_Y-101..Plasma X62_Y-102..Plasma X60_Y-104..Plasma X67_Y-86..Plasma #> PDK4              0.000000          0.000000          0.000000         0.000000 #> TNFRSF17          0.000000          0.000000          1.383680         0.000000 #> ICAM3             0.000000          4.676402          2.822824         0.000000 #> FAP               0.000000          0.000000          0.000000         0.000000 #> GZMB              5.012325          6.460370          0.000000         6.121496 #> TSC2              0.000000          0.000000          0.000000         0.000000 #>          X69_Y-86..Plasma X68_Y-88..Plasma X69_Y-87..Plasma X25_Y-105..Plasma #> PDK4             0.000000         0.000000         0.000000          1.535090 #> TNFRSF17         0.000000         0.000000         0.000000          0.000000 #> ICAM3            4.615121         0.000000         2.307560          2.930779 #> FAP              0.000000         0.000000         0.000000          0.000000 #> GZMB             0.000000         5.408168         2.829243          0.000000 #> TSC2             0.000000         0.000000         0.000000          0.000000 #>          X25_Y-106..Plasma X26_Y-106..Plasma X26_Y-107..Plasma #> PDK4             0.7002347          0.000000          0.000000 #> TNFRSF17         1.3393087          1.840627          2.010825 #> ICAM3            2.7151079          3.475919          4.085975 #> FAP              0.0000000          0.000000          0.000000 #> GZMB             1.6419427          1.282852          1.110574 #> TSC2             0.0000000          0.000000          0.000000 #>          X69_Y-102..Plasma X71_Y-104..Plasma X68_Y-105..Plasma #> PDK4                 0.000          0.000000          4.645283 #> TNFRSF17             0.000          4.018989          0.000000 #> ICAM3                0.000          0.000000          0.000000 #> FAP                  0.000          0.000000          0.000000 #> GZMB                 6.609          5.391713          0.000000 #> TSC2                 0.000          0.000000          0.000000 #>          X70_Y-105..Plasma X67_Y-106..Plasma X71_Y-106..Plasma #> PDK4              0.000000          0.000000          0.000000 #> TNFRSF17          0.000000          0.000000          0.000000 #> ICAM3             0.000000          0.000000          0.000000 #> FAP               0.000000          0.000000          0.000000 #> GZMB              5.908008          6.345822          6.587051 #> TSC2              0.000000          0.000000          0.000000 #>          X68_Y-107..Plasma X68_Y-106..Plasma X58_Y-104..Plasma #> PDK4              0.000000          0.000000          1.787886 #> TNFRSF17          0.000000          0.000000          1.914810 #> ICAM3             1.114950          0.000000          4.043811 #> FAP               0.000000          0.000000          0.000000 #> GZMB              4.230188          3.422141          0.000000 #> TSC2              0.000000          0.000000          0.000000 #>          X56_Y-105..Plasma X57_Y-105..Plasma X64_Y-104..Plasma #> PDK4              0.000000          0.000000          0.000000 #> TNFRSF17          0.000000          0.000000          0.000000 #> ICAM3             5.357848          0.000000          2.322641 #> FAP               0.000000          0.000000          0.000000 #> GZMB              0.000000          3.912415          2.917272 #> TSC2              0.000000          0.000000          0.000000 #>          X62_Y-105..Plasma X53_Y-106..Plasma X51_Y-106..Plasma #> PDK4              0.000000          0.000000          0.000000 #> TNFRSF17          0.000000          1.946078          0.000000 #> ICAM3             4.018989          1.777054          3.559047 #> FAP               0.000000          0.000000          0.000000 #> GZMB              0.000000          0.000000          0.000000 #> TSC2              0.000000          0.000000          0.000000 #>          X53_Y-107..Plasma X51_Y-107..Plasma X34_Y-104..Plasma #> PDK4              0.000000           0.00000          0.000000 #> TNFRSF17          3.501174           2.14130          4.900324 #> ICAM3             3.501174           4.37481          0.000000 #> FAP               0.000000           0.00000          0.000000 #> GZMB              0.000000           0.00000          0.000000 #> TSC2              0.000000           0.00000          0.000000 #>          X33_Y-104..Plasma X35_Y-107..Plasma X57_Y-98..Plasma X60_Y-100..Plasma #> PDK4              0.000000          0.000000         0.000000          2.205190 #> TNFRSF17          2.366787          0.000000         2.201191          0.000000 #> ICAM3             0.000000          3.786538         2.513632          0.000000 #> FAP               0.000000          0.000000         0.000000          0.000000 #> GZMB              1.238684          0.000000         3.315721          6.339624 #> TSC2              0.000000          0.000000         0.000000          0.000000 #>          X56_Y-103..Plasma X55_Y-103..Plasma X58_Y-99..Plasma X56_Y-99..Plasma #> PDK4              0.000000          0.000000         0.000000         4.848761 #> TNFRSF17          0.000000          1.685195         0.000000         0.000000 #> ICAM3             2.317563          0.000000         0.000000         5.537982 #> FAP               0.000000          0.000000         0.000000         0.000000 #> GZMB              0.000000          0.000000         6.892242         6.921321 #> TSC2              0.000000          0.000000         0.000000         0.000000 #>          X59_Y-103..Plasma X41_Y-98..Plasma X41_Y-99..Plasma X41_Y-100..Plasma #> PDK4              1.787886                0          0.00000          0.000000 #> TNFRSF17          0.000000                0          0.00000          0.000000 #> ICAM3             1.787886                0          2.73059          2.730590 #> FAP               0.000000                0          0.00000          0.000000 #> GZMB              0.000000                0          0.00000          2.829243 #> TSC2              0.000000                0          0.00000          0.000000 #>          X42_Y-100..Plasma X38_Y-100..Plasma X42_Y-101..Plasma #> PDK4              0.000000          4.434777          0.000000 #> TNFRSF17          2.665100          0.000000          0.000000 #> ICAM3             2.665100          4.434777          0.000000 #> FAP               0.000000          0.000000          0.000000 #> GZMB              2.829243          0.000000          5.658486 #> TSC2              0.000000          0.000000          0.000000 #>          X41_Y-102..Plasma X61_Y-86..Plasma X64_Y-86..Plasma X62_Y-87..Plasma #> PDK4              0.000000         0.000000         0.000000         0.000000 #> TNFRSF17          0.000000         0.000000         4.502979         0.000000 #> ICAM3             5.492796         0.000000         4.502979         1.998880 #> FAP               0.000000         0.000000         0.000000         0.000000 #> GZMB              5.492796         5.106143         5.880932         2.746398 #> TSC2              0.000000         0.000000         0.000000         0.000000 #>          X62_Y-88..Plasma X62_Y-90..Plasma X63_Y-91..Plasma X62_Y-86..Plasma #> PDK4             4.163422         0.000000         0.000000         0.000000 #> TNFRSF17         0.000000         0.000000         1.451907         0.000000 #> ICAM3            0.000000         0.000000         3.186568         0.000000 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             5.537982         5.589742         3.367279         5.492796 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X64_Y-91..Plasma X36_Y-91..Plasma X38_Y-94..Plasma X40_Y-94..Plasma #> PDK4             0.000000         0.000000         0.000000         0.000000 #> TNFRSF17         2.177861         0.000000         4.743091         2.888634 #> ICAM3            2.177861         4.585859         4.854128         1.545042 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             3.133900         0.000000         0.000000         0.000000 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X41_Y-96..Plasma X41_Y-94..Plasma X40_Y-105..Plasma X37_Y-106..Plasma #> PDK4             0.000000         0.000000          4.741765          0.000000 #> TNFRSF17         4.472554         4.836282          0.000000          0.000000 #> ICAM3            3.790760         0.000000          0.000000          5.007396 #> FAP              0.000000         0.000000          0.000000          0.000000 #> GZMB             0.000000         0.000000          6.813544          0.000000 #> TSC2             0.000000         0.000000          0.000000          0.000000 #>          X41_Y-107..Plasma X53_Y-86..Plasma X52_Y-86..Plasma X52_Y-87..Plasma #> PDK4              0.000000         0.422140        0.4746413         0.000000 #> TNFRSF17          0.000000         1.316659        1.8979018         0.000000 #> ICAM3             0.000000         3.116949        3.4622854         1.033435 #> FAP               0.000000         0.000000        0.0000000         0.000000 #> GZMB              5.758237         0.000000        0.5757567         0.000000 #> TSC2              0.000000         0.000000        0.0000000         0.000000 #>          X50_Y-87..Plasma X51_Y-87..Plasma X53_Y-87..Plasma X52_Y-88..Plasma #> PDK4             0.000000        0.0000000         0.000000        0.0000000 #> TNFRSF17         0.000000        0.4603567         1.569513        1.9752342 #> ICAM3            4.648065        2.4789001         3.092138        4.2095895 #> FAP              0.000000        0.0000000         0.000000        0.0000000 #> GZMB             1.092757        0.0000000         0.000000        0.4866193 #> TSC2             0.000000        0.0000000         0.000000        0.0000000 #>          X48_Y-88..Plasma X52_Y-89..Plasma X53_Y-89..Plasma X48_Y-89..Plasma #> PDK4             2.193290         0.000000        0.0000000         0.000000 #> TNFRSF17         0.000000         0.000000        0.9540675         2.354270 #> ICAM3            4.707864         1.079619        3.0704809         5.137839 #> FAP              0.000000         0.000000        0.0000000         0.000000 #> GZMB             1.497249         1.249402        0.0000000         0.000000 #> TSC2             0.000000         0.000000        0.0000000         0.000000 #>          X49_Y-89..Plasma X54_Y-89..Plasma X50_Y-89..Plasma X49_Y-90..Plasma #> PDK4             0.000000                0         0.000000         1.516052 #> TNFRSF17         3.161513                0         0.000000         4.056811 #> ICAM3            3.398095                0         4.653479         3.317274 #> FAP              0.000000                0         0.000000         0.000000 #> GZMB             0.000000                0         2.536743         0.000000 #> TSC2             0.000000                0         0.000000         0.000000 #>          X51_Y-90..Plasma X52_Y-90..Plasma X50_Y-90..Plasma X54_Y-90..Plasma #> PDK4             0.000000         0.000000        0.9096309        0.6818316 #> TNFRSF17         0.000000         0.000000        1.9340265        3.8386995 #> ICAM3            4.333204         2.456824        4.8560101        3.8020082 #> FAP              0.000000         0.000000        0.0000000        0.0000000 #> GZMB             0.000000         3.005025        1.0146972        0.0000000 #> TSC2             0.000000         0.000000        0.0000000        0.0000000 #>          X49_Y-91..Plasma X53_Y-85..Plasma X51_Y-86..Plasma X49_Y-88..Plasma #> PDK4             0.000000        0.0000000          0.00000         2.193290 #> TNFRSF17         0.000000        2.1473219          5.27712         0.000000 #> ICAM3            4.692024        2.9920727          5.27712         4.526249 #> FAP              0.000000        0.0000000          0.00000         0.000000 #> GZMB             0.000000        0.5454182          0.00000         0.000000 #> TSC2             0.000000        0.0000000          0.00000         0.000000 #>          X59_Y-89..Plasma X55_Y-89..Plasma X56_Y-90..Plasma X55_Y-90..Plasma #> PDK4                    0         0.000000         1.184146         1.160266 #> TNFRSF17                0         3.790760         2.722520         3.136257 #> ICAM3                   0         5.159975         4.472253         3.894207 #> FAP                     0         0.000000         0.000000         0.000000 #> GZMB                    0         0.000000         0.000000         0.000000 #> TSC2                    0         0.000000         0.000000         0.000000 #>          X57_Y-90..Plasma X55_Y-91..Plasma X56_Y-66..Plasma X73_Y-64..Plasma #> PDK4             1.006093        0.6818316         2.189387         0.000000 #> TNFRSF17         1.098612        3.0530212         0.000000         2.069407 #> ICAM3            1.177135        3.9625613         2.189387         2.069407 #> FAP              0.000000        0.0000000         0.000000         0.000000 #> GZMB             2.212508        0.0000000         0.000000         0.000000 #> TSC2             0.000000        0.0000000         0.000000         0.000000 #>          X71_Y-65..Plasma X48_Y-98..Plasma X53_Y-99..Plasma X48_Y-100..Plasma #> PDK4             4.340652         0.000000         0.000000          0.000000 #> TNFRSF17         4.340652         3.992524         4.282601          1.346841 #> ICAM3            0.000000         5.482145         5.371966          4.441842 #> FAP              0.000000         0.000000         0.000000          0.000000 #> GZMB             0.000000         0.000000         0.000000          1.473550 #> TSC2             0.000000         0.000000         0.000000          0.000000 #>          X48_Y-101..Plasma X49_Y-101..Plasma X54_Y-102..Plasma #> PDK4              0.000000          0.000000          0.000000 #> TNFRSF17          1.346841          0.000000          0.000000 #> ICAM3             4.599200          5.053963          0.000000 #> FAP               0.000000          0.000000          0.000000 #> GZMB              2.796814          4.367180          6.884087 #> TSC2              0.000000          0.000000          0.000000 #>          X49_Y-100..Plasma X50_Y-100..Plasma X43_Y-97..Plasma X43_Y-100..Plasma #> PDK4              0.000000          0.000000         0.000000          0.000000 #> TNFRSF17          4.008316          2.004158         1.961036          3.741288 #> ICAM3             0.000000          2.288148         2.302635          3.741288 #> FAP               0.000000          0.000000         0.000000          0.000000 #> GZMB              0.000000          2.288148         0.000000          0.000000 #> TSC2              0.000000          0.000000         0.000000          0.000000"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/HeatmapView.html","id":null,"dir":"Reference","previous_headings":"","what":"Draw Heatmap — HeatmapView","title":"Draw Heatmap — HeatmapView","text":"Draw Heatmap","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/HeatmapView.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Draw Heatmap — HeatmapView","text":"","code":"HeatmapView(   mat,   breaks = c(0, 0.6, 1.2),   colors = c(\"#ffffd9\", \"#edf8b1\", \"#225ea8\"),   na_col = \"grey\",   name = \"hmap\",   cluster_rows = FALSE,   row_dend_side = c(\"left\", \"right\"),   cluster_cols = FALSE,   column_dend_side = c(\"top\", \"bottom\"),   show_row_names = TRUE,   row_names_side = \"left\",   row_names_gp = gpar(fontsize = 12),   row_names_rot = 0,   show_column_names = TRUE,   column_names_side = \"bottom\",   column_names_gp = gpar(fontsize = 12),   column_names_rot = 90,   show_legend = TRUE,   top_ann = NULL,   top_ann_col = NULL,   show_top_legend = show_legend,   bott_ann = NULL,   bott_ann_col = NULL,   show_bott_legend = show_legend,   left_ann = NULL,   left_ann_col = NULL,   show_left_legend = show_legend,   right_ann = NULL,   right_ann_col = NULL,   show_right_legend = show_legend,   show_ann_name = TRUE,   annotation_legend_param = list(),   row_split = NULL,   column_split = NULL,   show_heatmap_legend = TRUE,   legend_title = NULL,   legend_title_position = \"lefttop\",   legend_direction = \"vertical\",   legend_title_gp = gpar(fontsize = 12),   legend_labels_gp = gpar(fontsize = 12),   legend_height = 2,   legend_width = 0.3,   legend_side = \"right\",   ... )"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/HeatmapView.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Draw Heatmap — HeatmapView","text":"mat Matrix like object. breaks vector indicating numeric breaks. colors vector colors correspond values breaks. na_col Color NA values. name Heatmap name. cluster_rows ComplexHeatmap::Heatmap. row_dend_side ComplexHeatmap::Heatmap. cluster_cols ComplexHeatmap::Heatmap. column_dend_side ComplexHeatmap::Heatmap. show_row_names ComplexHeatmap::Heatmap. row_names_side ComplexHeatmap::Heatmap. row_names_gp ComplexHeatmap::Heatmap. row_names_rot ComplexHeatmap::Heatmap. show_column_names ComplexHeatmap::Heatmap. column_names_side ComplexHeatmap::Heatmap. column_names_gp ComplexHeatmap::Heatmap. column_names_rot ComplexHeatmap::Heatmap. show_legend Whether show annotation legends. top_ann data frame. column treated simple annotation. data frame must column names. Can also HeatmapAnnotation-class object. top_ann_col list colors contain color mapping df. show_top_legend Whether show annotation legends. bott_ann top_ann. bott_ann_col list colors contain color mapping df. show_bott_legend Whether show annotation legends. left_ann top_ann. left_ann_col list colors contain color mapping df. show_left_legend Whether show annotation legends. right_ann top_ann. right_ann_col list colors contain color mapping df. show_right_legend Whether show annotation legends. show_ann_name Whether show annotation names. annotation_legend_param list contains parameters annotation legends. row_split vector data frame rows split. cluster_rows clustering object, split can single number indicating split dendrogram cutree. column_split row_split. show_heatmap_legend Whether show legends. legend_title Character specifyin legend title. legend_title_position Position title relative legend. topleft, topcenter, leftcenter-rot lefttop-rot vertical legend leftcenter, lefttop horizontal legend. legend_direction Vertical horizontal? legend_title_gp Graphic parameters title. legend_labels_gp Graphic parameters labels. legend_height Height whole legend body. used vertical continous legend. legend_width Width whole legend body. used horizontal continous legend. legend_side Side put heatmap legend ... parameters draw.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/HeatmapView.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Draw Heatmap — HeatmapView","text":"`Heatmap-class` object.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/HeatmapView.html","id":"author","dir":"Reference","previous_headings":"","what":"Author","title":"Draw Heatmap — HeatmapView","text":"Wubing Zhang","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/HeatmapView.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Draw Heatmap — HeatmapView","text":"","code":"library(grid) library(SpatialEcoTyper) library(ComplexHeatmap) #> ======================================== #> ComplexHeatmap version 2.20.0 #> Bioconductor page: http://bioconductor.org/packages/ComplexHeatmap/ #> Github page: https://github.com/jokergoo/ComplexHeatmap #> Documentation: http://jokergoo.github.io/ComplexHeatmap-reference #>  #> If you use it in published research, please cite either one: #> - Gu, Z. Complex Heatmap Visualization. iMeta 2022. #> - Gu, Z. Complex heatmaps reveal patterns and correlations in multidimensional  #>     genomic data. Bioinformatics 2016. #>  #>  #> The new InteractiveComplexHeatmap package can directly export static  #> complex heatmaps into an interactive Shiny app with zero effort. Have a try! #>  #> This message can be suppressed by: #>   suppressPackageStartupMessages(library(ComplexHeatmap)) #> ========================================  dat = matrix(rnorm(100), 10) rownames(dat) = letters[1:10] colnames(dat) = letters[11:20] rowann = data.frame(Group = rep(letters[1:2], each=5), index = 1:10) colann = data.frame(Group = rep(letters[1:2], each=5), index = 11:20) HeatmapView(dat, left_ann = rowann, top_ann = colann) #> Loading required package: pals"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/Integrate.html","id":null,"dir":"Reference","previous_headings":"","what":"Integrate Spatial Clusters From Multiple Samples Via Similarity Network Fusion — Integrate","title":"Integrate Spatial Clusters From Multiple Samples Via Similarity Network Fusion — Integrate","text":"function identifies conserved spatial ecotypes based cell type specific gene expression signature spatial clusters samples.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/Integrate.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Integrate Spatial Clusters From Multiple Samples Via Similarity Network Fusion — Integrate","text":"","code":"Integrate(   avgexprs,   Region = NULL,   nfeatures = 3000,   min.features = 5,   minibatch = 5000,   ncores = 1 )"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/Integrate.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Integrate Spatial Clusters From Multiple Samples Via Similarity Network Fusion — Integrate","text":"avgexprs Gene expression signature spatial clusters, column represents spatial cluster. Region character vector specifying region annotations spatial clusters. nfeatures Integer specifying maximum number top variable genes select cell type. min.features Integer specifying minimum number shared features (genes) required across samples. minibatch Integer specifying number columns process minibatch SNF analysis. Default 5000. option splits matrix smaller chunks (minibatch), thus reducing memory usage. ncores Integer specifying number cores parallel processing. Default 1.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/Integrate.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Integrate Spatial Clusters From Multiple Samples Via Similarity Network Fusion — Integrate","text":"Integrated similarity matrix spatial clusters across samples.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/IntegrateSpatialEcoTyper.html","id":null,"dir":"Reference","previous_headings":"","what":"Integrate Multiple Spatial Transcriptomics Datasets to Identify Conserved Spatial Ecotypes — IntegrateSpatialEcoTyper","title":"Integrate Multiple Spatial Transcriptomics Datasets to Identify Conserved Spatial Ecotypes — IntegrateSpatialEcoTyper","text":"Integrate Multiple Spatial Transcriptomics Datasets Identify Conserved Spatial Ecotypes","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/IntegrateSpatialEcoTyper.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Integrate Multiple Spatial Transcriptomics Datasets to Identify Conserved Spatial Ecotypes — IntegrateSpatialEcoTyper","text":"","code":"IntegrateSpatialEcoTyper(   SpatialEcoTyper_list,   data_list,   outdir = \"./\",   normalization.method = \"None\",   nmf_ranks = 10,   nrun.per.rank = 30,   min.coph = 0.95,   nfeatures = 3000,   min.features = 10,   Region = NULL,   subresolution = 30,   minibatch = 5000,   ncores = 1,   seed = 1 )"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/IntegrateSpatialEcoTyper.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Integrate Multiple Spatial Transcriptomics Datasets to Identify Conserved Spatial Ecotypes — IntegrateSpatialEcoTyper","text":"SpatialEcoTyper_list named list SpatialEcoTyper results, item represents list returned SpatialEcoTyper function. data_list named list expression matrices matrix represents gene expression data used SpatialEcoTyper analysis. list name match SpatialEcoTyper_list. outdir Directory results saved. Defaults current directory subdirectory named \"SpatialEcoTyper_results_\" followed current date. normalization.method Method normalizing expression data. Options include \"None\" (default), \"SCT\", methods compatible Seurat's `NormalizeData` function. nmf_ranks Integer vector specifying number clusters (10 default). integer vector supplied, function test supplied numbers select optimal number, takes time. nrun.per.rank integer specifying number runs per rank NMF (default: 30). min.coph Numeric specifying minimum cophenetic coefficient required rank optimal. nfeatures integer specifying maximum number top variable genes select cell type. min.features integer specifying minimum number shared features (genes) required across samples. Region character string specifying column name metadata data frames containing region annotations (default: NULL). Pathologist annotation recommended available. subresolution numeric specifying resolution clustering within sample. minibatch Integer specifying number columns process minibatch SNF analysis. Default 5000. option splits matrix smaller chunks (minibatch), thus reducing memory usage. ncores integer specifying number cores parallel processing. Default 1. seed integer used seed random number generator NMF analysis.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/IntegrateSpatialEcoTyper.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Integrate Multiple Spatial Transcriptomics Datasets to Identify Conserved Spatial Ecotypes — IntegrateSpatialEcoTyper","text":"","code":"# See https://digitalcytometry.github.io/SpatialEcoTyper/docs/articles/Integration.html"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/MultiSpatialEcoTyper.html","id":null,"dir":"Reference","previous_headings":"","what":"Integrate Multiple Spatial Transcriptomics Datasets to Identify Conserved Spatial Ecotypes — MultiSpatialEcoTyper","title":"Integrate Multiple Spatial Transcriptomics Datasets to Identify Conserved Spatial Ecotypes — MultiSpatialEcoTyper","text":"function performs SpatialEcoTyper analysis multiple spatial transcriptomics datasets. normalizes input data, performs SpatialEcoTyper analysis dataset, integrates results across samples.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/MultiSpatialEcoTyper.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Integrate Multiple Spatial Transcriptomics Datasets to Identify Conserved Spatial Ecotypes — MultiSpatialEcoTyper","text":"","code":"MultiSpatialEcoTyper(   data_list,   metadata_list,   outdir = \"./\",   normalization.method = \"None\",   nmf_ranks = 10,   nrun.per.rank = 30,   min.coph = 0.95,   radius = 50,   min.cts.per.region = 1,   nfeatures = 3000,   min.features = 10,   Region = NULL,   subresolution = 30,   minibatch = 5000,   ncores = 1,   seed = 1,   filter.region.by.celltypes = NULL,   ... )"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/MultiSpatialEcoTyper.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Integrate Multiple Spatial Transcriptomics Datasets to Identify Conserved Spatial Ecotypes — MultiSpatialEcoTyper","text":"data_list named list expression matrices matrix represents gene expression data sample. columns matrix correspond cells, rows correspond genes. Sample names used list names. Otherwise, samples named 'Sample1' 'SampleN'. metadata_list named list metadata data frames data frame contains metadata corresponding cells expression matrices. row correspond column (cell) expression matrices. metadata include least three columns, including X, Y CellType. outdir Directory results saved. Defaults current directory subdirectory named \"SpatialEcoTyper_results_\" followed current date. normalization.method Method normalizing expression data. Options include \"None\" (default), \"SCT\", methods compatible Seurat's `NormalizeData` function. nmf_ranks Integer vector specifying number clusters (10 default). integer vector supplied, function test supplied numbers select optimal number, takes time. nrun.per.rank integer specifying number runs per rank NMF (default: 30). min.coph Numeric specifying minimum cophenetic coefficient required rank optimal. radius Numeric specifying radius (units spatial coordinates) defining spatial neighborhoods around cell. Default 50. min.cts.per.region Integer specifying minimum number cell types required microregion. nfeatures integer specifying maximum number top variable genes select cell type. min.features integer specifying minimum number shared features (genes) required across samples. Region Character string specifying column name metadata data frames containing region annotations (default: NULL). Pathologist annotation recommended available. subresolution Numeric specifying resolution clustering within sample. minibatch Integer specifying number columns process minibatch SNF analysis. Default 5000. option splits matrix smaller chunks (minibatch), thus reducing memory usage. ncores Integer specifying number cores parallel processing. Default 1. seed integer used seed random number generator NMF analysis. filter.region..celltypes character vector specifying cell types include analysis. spatial microregions contain least one specified cell types analyzed, regions lacking cell types excluded SE discovery process. NULL, spatial microregions included, regardless cell type composition. ... Additional arguments passed `SpatialEcoTyper` function.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/MultiSpatialEcoTyper.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Integrate Multiple Spatial Transcriptomics Datasets to Identify Conserved Spatial Ecotypes — MultiSpatialEcoTyper","text":"function saves results specified output directory.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/MultiSpatialEcoTyper.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Integrate Multiple Spatial Transcriptomics Datasets to Identify Conserved Spatial Ecotypes — MultiSpatialEcoTyper","text":"function takes list gene expression matrices corresponding metadata,          normalizes data specified, performs SpatialEcoTyper sample,          integrates results across multiple samples identify conserved spatial ecotypes.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/MultiSpatialEcoTyper.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Integrate Multiple Spatial Transcriptomics Datasets to Identify Conserved Spatial Ecotypes — MultiSpatialEcoTyper","text":"","code":"# See https://digitalcytometry.github.io/SpatialEcoTyper/docs/articles/Integration.html"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/NMFGenerateW.html","id":null,"dir":"Reference","previous_headings":"","what":"Train SE Deconvolution Model — NMFGenerateW","title":"Train SE Deconvolution Model — NMFGenerateW","text":"function trains Non-negative Matrix Factorization (NMF) model SE deconvolution based given spatial ecotype fractions gene expression matrix. Prior NMF, gene scaled mean 0 unit variance. satisfy non-negativity requirement NMF, expression matrix processed using posneg transformation, converts expression matrix two matrices, one containing positive values containing negative values sign inverted. two matrices subsequently concatenated produce training data.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/NMFGenerateW.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Train SE Deconvolution Model — NMFGenerateW","text":"","code":"NMFGenerateW(   Fracs,   ExpMat,   scale = TRUE,   nfeature = 2000,   nfeature.per.se = 50,   method = \"brunet\" )"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/NMFGenerateW.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Train SE Deconvolution Model — NMFGenerateW","text":"Fracs fraction matrix, rows samples. ExpMat gene expression matrix genes rows samples columns. scale Logical indicating whether scale gene expression matrix. Default TRUE. nfeature Integer specifying top variable features training models (default: 2000). nfeature.per.se Integer specifying maximal number features select SE (default: 50). method character string specifying NMF method use. Default \"brunet\".","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/NMFGenerateW.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Train SE Deconvolution Model — NMFGenerateW","text":"matrix containing basis NMF W matrix rows features columns SEs.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/NMFGenerateWList.html","id":null,"dir":"Reference","previous_headings":"","what":"Train Cell Type-Specific NMF Models for Recovering Spatial EcoTypes — NMFGenerateWList","title":"Train Cell Type-Specific NMF Models for Recovering Spatial EcoTypes — NMFGenerateWList","text":"function trains cell type-specific NMF (Non-Negative Matrix Factorization) models recover SE-specific cell states single-cell data, part Spatial EcoTyper analysis workflow. downsamples cells training dataset size large, selects subset features highest specificity.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/NMFGenerateWList.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Train Cell Type-Specific NMF Models for Recovering Spatial EcoTypes — NMFGenerateWList","text":"","code":"NMFGenerateWList(   scdata,   scmeta,   CellType = \"CellType\",   SE = \"SE\",   scale = TRUE,   Sample = NULL,   balance.sample = TRUE,   nfeature = 2000,   nfeature.per.se = 50,   min.cells = 20,   downsample = 2500,   ncores = 1,   seed = 2024 )"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/NMFGenerateWList.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Train Cell Type-Specific NMF Models for Recovering Spatial EcoTypes — NMFGenerateWList","text":"scdata Numeric matrix containing single-cell expression data. scmeta Data frame containing metadata information associated single-cell data, including cell types spatial clusters. CellType Character string specifying column name metadata data frame containing cell type annotations. SE Character string specifying column name metadata data frame containing spatial ecotype annotations. scale Boolean specifying whether perform univariance normalization training models (default: TRUE). Sample Character string specifying column name metadata data frame containing sample annotations. specified, univariance normalization performed within sample. balance.sample Boolean specifying whether perform balance cells samples training models (default: TRUE). nfeature Integer specifying top variable features training models (default: 2000). nfeature.per.se Integer specifying maximal number features select SE (default: 50). min.cells Integer specifying minimal number cells required SE cell state. downsample Integer specifying number cells per cell type (downsampling) training NMF models (default: 2500). ncores Integer specifying number CPU cores use parallel processing. seed Integer specifying seed random sampling downsampling.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/NMFGenerateWList.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Train Cell Type-Specific NMF Models for Recovering Spatial EcoTypes — NMFGenerateWList","text":"list cell type-specific NMF models, represented corresponding factorization matrix W.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/NMFpredict.html","id":null,"dir":"Reference","previous_headings":"","what":"Prediction Using Pretrained NMF Model — NMFpredict","title":"Prediction Using Pretrained NMF Model — NMFpredict","text":"function uses pretrained NMF models recover cell states / spatial ecotypes. takes factorization matrix W representing pretrained NMF model numeric gene expression matrix.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/NMFpredict.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Prediction Using Pretrained NMF Model — NMFpredict","text":"","code":"NMFpredict(W, testdat, scale = FALSE, ncell.per.run = 500)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/NMFpredict.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Prediction Using Pretrained NMF Model — NMFpredict","text":"W Matrix representing factorization matrix W pretrained NMF model. testdat Numeric matrix containing new data NMF scores predicted. scale Logical indicating whether scale input data. ncell.per.run Integer specifying maximum number cells per NMF prediction run avoid memory issues.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/NMFpredict.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Prediction Using Pretrained NMF Model — NMFpredict","text":"matrix representing NMF prediction scores.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/NMFpredict.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Prediction Using Pretrained NMF Model — NMFpredict","text":"","code":"library(googledrive) drive_deauth() # no Google sign-in is required drive_download(as_id(\"14QvmgISxaArTzWt_UHvf55aAYN2zm84Q\"), \"SKCM_RNASeqV2.geneExp.rds\",                     overwrite = TRUE) #> File downloaded: #> • SKCM_RNASeqV2.geneExp.rds  #> Saved locally as: #> • SKCM_RNASeqV2.geneExp.rds bulkdata <- readRDS(\"SKCM_RNASeqV2.geneExp.rds\") W <- readRDS(file.path(system.file(\"extdata\", package = \"SpatialEcoTyper\"), \"Bulk_SE_Recovery_W.rds\"))  # Predict SE abundances in bulk tumors preds <- NMFpredict(W = W, bulkdata, scale = TRUE) head(preds[, 1:5]) #>       TCGA-3N-A9WB-06 TCGA-3N-A9WC-06 TCGA-3N-A9WD-06 TCGA-BF-A1PU-01 #> nonSE      0.10378493     0.031103139     0.469932888      0.12913097 #> SE1        0.08326065     0.063022079     0.151414386      0.18470256 #> SE2        0.25368726     0.051110136     0.068248720      0.09710288 #> SE3        0.09417615     0.173416088     0.004969678      0.06966202 #> SE4        0.07931696     0.028829349     0.056418588      0.16008800 #> SE5        0.05088193     0.003203951     0.056310297      0.05303787 #>       TCGA-BF-A1PV-01 #> nonSE      0.10221472 #> SE1        0.05277487 #> SE2        0.05740510 #> SE3        0.15960054 #> SE4        0.12876903 #> SE5        0.12002292"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/PreprocessST.html","id":null,"dir":"Reference","previous_headings":"","what":"Preprocess Spatial Transcriptomics Data — PreprocessST","title":"Preprocess Spatial Transcriptomics Data — PreprocessST","text":"function preprocesses single-cell spatial transcriptomics data filtering low-quality genes cells based specified thresholds. ensures genes expressed minimum number cells cells expressing minimum number features retained. Additionally, reformats metadata include spatial coordinates (X Y).","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/PreprocessST.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Preprocess Spatial Transcriptomics Data — PreprocessST","text":"","code":"PreprocessST(   expdat,   metadata,   min.cells = 3,   min.features = 5,   X = \"X\",   Y = \"Y\" )"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/PreprocessST.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Preprocess Spatial Transcriptomics Data — PreprocessST","text":"expdat matrix data frame representing gene expression data, rows correspond genes columns correspond cells. metadata data frame containing metadata associated cell. Must include spatial coordinates (e.g., X Y) well cell-specific annotations. row names `metadata` must match column names `expdat`. min.cells integer specifying minimum number cells gene must expressed retained (default 3). min.features integer specifying minimum number features (genes) cell must express retained (default 5). X string specifying column name metadata data frame represents X spatial coordinate (default \"X\"). Y string specifying column name metadata data frame represents Y spatial coordinate (default \"Y\").","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/PreprocessST.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Preprocess Spatial Transcriptomics Data — PreprocessST","text":"list containing two elements: expdat filtered matrix gene expression data, converted sparse matrix metadata filtered data frame metadata, aligned filtered gene expression data, including reformatted spatial coordinates.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/PreprocessST.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Preprocess Spatial Transcriptomics Data — PreprocessST","text":"","code":"library(SpatialEcoTyper) library(data.table) library(googledrive) drive_deauth() # no Google sign-in is required drive_download(as_id(\"1CgUOQKrWY_TG61o5aw7J9LZzE20D6NuI\"),                     \"HumanMelanomaPatient1_subset_scmeta.tsv\", overwrite = TRUE) #> File downloaded: #> • HumanMelanomaPatient1_subset_scmeta.tsv #>    #> Saved locally as: #> • HumanMelanomaPatient1_subset_scmeta.tsv drive_download(as_id(\"1CoQmU3u8MoVC8RbLUvTDQmOuJJ703HHB\"),               \"HumanMelanomaPatient1_subset_counts.tsv.gz\", overwrite = TRUE) #> File downloaded: #> • HumanMelanomaPatient1_subset_counts.tsv.gz #>    #> Saved locally as: #> • HumanMelanomaPatient1_subset_counts.tsv.gz scdata <- fread(\"HumanMelanomaPatient1_subset_counts.tsv.gz\",                 sep = \"\\t\",header = TRUE, data.table = FALSE) rownames(scdata) <- scdata[, 1] scdata <- as.matrix(scdata[, -1]) scmeta <- read.table(\"HumanMelanomaPatient1_subset_scmeta.tsv\",                      sep = \"\\t\", header = TRUE, row.names = 1) processed <- PreprocessST(expdat = scdata, scmeta, X = \"X\", Y = \"Y\",                           min.cells = 3, min.features = 5) #> 2024-11-06 21:40:31.278444 Remove 87 genes expressed in fewer than 3 cells head(processed$metadata) #>                                         X         Y   CellType CellTypeName #> HumanMelanomaPatient1__cell_3655 1894.706 -6367.766 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3657 1942.480 -6369.602 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3658 1963.007 -6374.026 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3660 1981.600 -6372.266 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3661 1742.939 -6374.851 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3663 1921.683 -6383.309 Fibroblast  Fibroblasts #>                                  Region Dist2Interface #> HumanMelanomaPatient1__cell_3655 Stroma      -883.1752 #> HumanMelanomaPatient1__cell_3657 Stroma      -894.8463 #> HumanMelanomaPatient1__cell_3658 Stroma      -904.1115 #> HumanMelanomaPatient1__cell_3660 Stroma      -907.8909 #> HumanMelanomaPatient1__cell_3661 Stroma      -874.2712 #> HumanMelanomaPatient1__cell_3663 Stroma      -903.6559 head(processed$expdat) #> 6 x 27907 sparse Matrix of class \"dgCMatrix\" #>   [[ suppressing 34 column names ‘HumanMelanomaPatient1__cell_3655’, ‘HumanMelanomaPatient1__cell_3657’, ‘HumanMelanomaPatient1__cell_3658’ ... ]] #>                                                                              #> PDK4     . 1 1 . . . . . . . . . . . . 1 . 2 1 . 1 . . . 2 2 . . . . . . . 1 #> TNFRSF17 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . #> ICAM3    . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . #> FAP      1 . . . . 1 2 1 . 1 . 1 . . . . . . . . 1 . . . . . 1 1 . 1 . . . 1 #> GZMB     . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 . . . . #> TSC2     . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . #>                 #> PDK4     ...... #> TNFRSF17 ...... #> ICAM3    ...... #> FAP      ...... #> GZMB     ...... #> TSC2     ...... #>  #>  .....suppressing 27873 columns in show(); maybe adjust options(max.print=, width=) #>  .............................."},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/RecoverSE.html","id":null,"dir":"Reference","previous_headings":"","what":"Recovery of SEs Using Pretrained NMF Models — RecoverSE","title":"Recovery of SEs Using Pretrained NMF Models — RecoverSE","text":"function can recover SEs Visium, scRNA-seq data single-cell spatial data.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/RecoverSE.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Recovery of SEs Using Pretrained NMF Models — RecoverSE","text":"","code":"RecoverSE(dat, scale = TRUE, Ws = NULL, celltypes = NULL, se_results = NULL)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/RecoverSE.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Recovery of SEs Using Pretrained NMF Models — RecoverSE","text":"dat numeric matrix gene expression data, single-cell spatial transcriptomics, scRNA-seq spot-resolution spatial transcriptomics data. scale Logical indicating whether scale input data predictions. Ws list cell-type-specific W matrices used recover SE-specific cell states. element list named corresponding cell type contain W matrix NMF model. celltypes Character string specifying cell type annotations, required scRNA-seq single-cell spatial data. se_results list including seurat object metadata spatial cluster annotations (SE column) returned SpatialEcoTyper. supplied, `dat` single cell gene expression data used SpatialEcoTyper analysis.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/RecoverSE.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Recovery of SEs Using Pretrained NMF Models — RecoverSE","text":"Depending input data: - single-cell data: vector predicted SEs cell. - spot-resolution data (e.g., Visium): matrix SE abundances across spots.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/RecoverSE.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Recovery of SEs Using Pretrained NMF Models — RecoverSE","text":"","code":"# see https://digitalcytometry.github.io/SpatialEcoTyper_dev/articles/Recovery_scRNA.html # see https://digitalcytometry.github.io/SpatialEcoTyper_dev/articles/Recovery_Spatial.html"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/SNF2.html","id":null,"dir":"Reference","previous_headings":"","what":"Enhanced Similarity Network Fusion — SNF2","title":"Enhanced Similarity Network Fusion — SNF2","text":"Similarity Network Fusion (SNF) integrates multiple views (similarity matrices) construct overall status matrix. function adopted SNFtool (https://github.com/maxconway/SNFtool/) enhanced unsupervised analysis spatial ecosystem. new function supports sparse matrix missing data input matrices.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/SNF2.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Enhanced Similarity Network Fusion — SNF2","text":"","code":"SNF2(Wall, K = 50, t = 5, minibatch = 5000, ncores = 1, verbose = FALSE)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/SNF2.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Enhanced Similarity Network Fusion — SNF2","text":"Wall List similarity matrices. element list square, symmetric matrix shows affinities data points certain view. K Number neighbors K-nearest neighbors part algorithm. t Number iterations diffusion process. minibatch Integer specifying number columns process minibatch. Default 5000. option splits matrix smaller chunks (minibatch), thus reducing memory usage. ncores Integer specifying number CPU cores use parallel processing. verbose Boolean specifying whether show progress messages.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/SNF2.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Enhanced Similarity Network Fusion — SNF2","text":"fused matrix.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/SpatialEcoTyper.html","id":null,"dir":"Reference","previous_headings":"","what":"Identify Spatial EcoTypes from Single-cell Spatial Data (A Single Sample) — SpatialEcoTyper","title":"Identify Spatial EcoTypes from Single-cell Spatial Data (A Single Sample) — SpatialEcoTyper","text":"function identifies spatially distinct cellular ecosystems (SE) single sample.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/SpatialEcoTyper.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Identify Spatial EcoTypes from Single-cell Spatial Data (A Single Sample) — SpatialEcoTyper","text":"","code":"SpatialEcoTyper(   normdata,   metadata,   outprefix = \"SE\",   radius = 50,   resolution = 0.5,   nfeatures = 3000,   min.cts.per.region = 1,   npcs = 20,   k.sn = 50,   k = 20,   min.cells = 5,   min.features = 10,   iterations = 5,   minibatch = 5000,   ncores = 1,   binsize = round(radius * 1.4),   filter.region.by.celltypes = NULL )"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/SpatialEcoTyper.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Identify Spatial EcoTypes from Single-cell Spatial Data (A Single Sample) — SpatialEcoTyper","text":"normdata matrix representing normalized gene expression data, rows correspond genes columns correspond cells. metadata data frame containing metadata associated cell. Must include spatial coordinates (e.g., X Y) well cell type annotations. row names metadata must match column names normdata. outprefix Character string specifying prefix output file names. radius Numeric specifying radius (units spatial coordinates) defining spatial neighborhoods around cell. Default 50. resolution Numeric specifying resolution Louvain clustering (default: 0.5). nfeatures Integer specifying number top variable features (default: 3000) used PCA. min.cts.per.region Integer specifying minimum number cell types required microregion. npcs Integer specifying number principal components (PCs) (default: 20). k.sn Integer specifying number spatial nearest neighbors (default: 50) constructing similarity network. k Integer specifying number spatial nearest neighbors (default: 20) used construct spatial meta-cells. min.cells Minimum number cells / spatial-meta-cells (default: 5)  expressing feature/gene. min.features Minimum number features (default: 10) detected cell / spatial-meta-cell. iterations Integer specifying number iterations (default: 5) SNF analysis. minibatch Integer specifying number columns process minibatch SNF analysis. Default 5000. option splits matrix smaller chunks (minibatch), thus reducing memory usage. ncores Integer specifying number CPU cores use parallel processing. binsize Numeric specifying bin size spatial discretization coordinates. default, size determined based specified radius (radius*1.4 µm). Increasing binsize downsample microregions expedite analysis, might eliminate cells located bins SE discovery analysis. filter.region..celltypes character vector specifying cell types include analysis. spatial microregions contain least one specified cell types analyzed, regions lacking cell types excluded SE discovery process. NULL, spatial microregions included, regardless cell type composition. #' @return list containing two elements: obj seurat object constructed fused similarity network sptial microregions metadata Updated metadata, new column (`SE`) added","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/SpatialEcoTyper.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Identify Spatial EcoTypes from Single-cell Spatial Data (A Single Sample) — SpatialEcoTyper","text":"","code":"# See https://digitalcytometry.github.io/SpatialEcoTyper/docs/articles/SingleSample.html suppressPackageStartupMessages(library(dplyr)) suppressPackageStartupMessages(library(ggplot2)) suppressPackageStartupMessages(library(parallel)) suppressPackageStartupMessages(library(Seurat)) suppressPackageStartupMessages(library(data.table)) suppressPackageStartupMessages(library(googledrive)) suppressPackageStartupMessages(library(R.utils)) library(SpatialEcoTyper)  drive_deauth() # Disable Google sign-in requirement drive_download(as_id(\"13Rc5Rsu8jbnEYYfUse-xQ7ges51LcI7n\"), \"HumanMelanomaPatient1_subset_counts.tsv.gz\") #> Error in drive_download(as_id(\"13Rc5Rsu8jbnEYYfUse-xQ7ges51LcI7n\"), \"HumanMelanomaPatient1_subset_counts.tsv.gz\"): Local `path` already exists and overwrite is `FALSE`: #> • HumanMelanomaPatient1_subset_counts.tsv.gz drive_download(as_id(\"12xcZNhpT-xbhcG8kX1QAdTeM9TKeFAUW\"), \"HumanMelanomaPatient1_subset_scmeta.tsv\") #> Error in drive_download(as_id(\"12xcZNhpT-xbhcG8kX1QAdTeM9TKeFAUW\"), \"HumanMelanomaPatient1_subset_scmeta.tsv\"): Local `path` already exists and overwrite is `FALSE`: #> • HumanMelanomaPatient1_subset_scmeta.tsv  # Load single-cell gene expression matrix. Rows are genes, columns are cells. scdata <- fread(\"HumanMelanomaPatient1_subset_counts.tsv.gz\",                 sep = \"\\t\",header = TRUE, data.table = FALSE) rownames(scdata) <- scdata[, 1]  # set genes as row names scdata <- as.matrix(scdata[, -1]) normdata <- NormalizeData(scdata) head(normdata[, 1:5]) #>          HumanMelanomaPatient1__cell_3655 HumanMelanomaPatient1__cell_3657 #> PDK4                             0.000000                         4.221184 #> TNFRSF17                         0.000000                         0.000000 #> ICAM3                            0.000000                         0.000000 #> FAP                              3.552438                         0.000000 #> GZMB                             0.000000                         0.000000 #> TSC2                             0.000000                         0.000000 #>          HumanMelanomaPatient1__cell_3658 HumanMelanomaPatient1__cell_3660 #> PDK4                             3.208945                                0 #> TNFRSF17                         0.000000                                0 #> ICAM3                            0.000000                                0 #> FAP                              0.000000                                0 #> GZMB                             0.000000                                0 #> TSC2                             0.000000                                0 #>          HumanMelanomaPatient1__cell_3661 #> PDK4                                    0 #> TNFRSF17                                0 #> ICAM3                                   0 #> FAP                                     0 #> GZMB                                    0 #> TSC2                                    0  # Load single-cell metadata. Three columns are required, including X, Y, and CellType. Others are optional. scmeta <- read.table(\"HumanMelanomaPatient1_subset_scmeta.tsv\",                      sep = \"\\t\",header = TRUE, row.names = 1) scmeta <- scmeta[colnames(scdata), ] # match the cell ids in scdata and scmeta head(scmeta) #>                                         X         Y   CellType CellTypeName #> HumanMelanomaPatient1__cell_3655 1894.706 -6367.766 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3657 1942.480 -6369.602 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3658 1963.007 -6374.026 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3660 1981.600 -6372.266 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3661 1742.939 -6374.851 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3663 1921.683 -6383.309 Fibroblast  Fibroblasts #>                                  Region Dist2Interface #> HumanMelanomaPatient1__cell_3655 Stroma      -883.1752 #> HumanMelanomaPatient1__cell_3657 Stroma      -894.8463 #> HumanMelanomaPatient1__cell_3658 Stroma      -904.1115 #> HumanMelanomaPatient1__cell_3660 Stroma      -907.8909 #> HumanMelanomaPatient1__cell_3661 Stroma      -874.2712 #> HumanMelanomaPatient1__cell_3663 Stroma      -903.6559  se_results <- SpatialEcoTyper(normdata, scmeta,                               outprefix = \"Melanoma1_subset\",                               radius = 50, ncores = 2) #> 2024-11-06 21:40:33.351806 Remove 88 genes expressed in fewer than 5 cells #> 2024-11-06 21:40:33.669924 Construct spatial meta cells for each cell type #> \t\tTotal spatial microregions: 2315 #> \t\tTotal spatial meta cells: 7711 #> 2024-11-06 21:40:44.397087 PCA for each cell type #> 2024-11-06 21:40:46.028613 Construct cell-type-specific similarity network #> 2024-11-06 21:40:46.687294 Similarity network fusion #> 2024-11-06 21:40:46.688753 Normalize networks ... #> 2024-11-06 21:40:46.763675 Calculate the local transition matrix ... #> 2024-11-06 21:40:47.215871 Perform the diffusion ... #> \t2024-11-06 21:40:47.216931 Iteration: 1 #> \t2024-11-06 21:40:51.881714 Iteration: 2 #> \t2024-11-06 21:41:14.434246 Iteration: 3 #> \t2024-11-06 21:41:41.458828 Iteration: 4 #> \t2024-11-06 21:42:06.833207 Iteration: 5 #> 2024-11-06 21:42:33.750084 Create Seurat object and perform clustering analysis #> Warning: Data is of class dgeMatrix. Coercing to dgCMatrix. #> Warning: The default method for RunUMAP has changed from calling Python UMAP via reticulate to the R-native UWOT using the cosine metric #> To use Python UMAP via reticulate, set umap.method to 'umap-learn' and metric to 'correlation' #> This message will be shown once per session #> 2024-11-06 21:42:44.872975 The Seurat object is saved into Melanoma1_subset_SpatialEcoTyper_results.rds # Extract the Seurat object and updated single-cell metadata obj <- se_results$obj # A Seurat object obj #> An object of class Seurat  #> 2315 features across 2315 samples within 1 assay  #> Active assay: RNA (2315 features, 2315 variable features) #>  3 layers present: counts, data, scale.data #>  2 dimensional reductions calculated: pca, umap scmeta <- se_results$metadata %>% arrange(SE) # Updated single-cell meta data, with SE annotation added head(scmeta) #>                                         X         Y   CellType CellTypeName #> HumanMelanomaPatient1__cell_3661 1742.939 -6374.851 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3664 1706.253 -6383.428 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3666 1761.403 -6387.970 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3668 1841.514 -6389.663 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3670 1741.536 -6395.796 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3674 1907.099 -6411.773 Fibroblast  Fibroblasts #>                                  Region Dist2Interface  SE #> HumanMelanomaPatient1__cell_3661 Stroma      -874.2712 SE0 #> HumanMelanomaPatient1__cell_3664 Stroma      -880.4758 SE0 #> HumanMelanomaPatient1__cell_3666 Stroma      -888.6271 SE0 #> HumanMelanomaPatient1__cell_3668 Stroma      -896.8484 SE0 #> HumanMelanomaPatient1__cell_3670 Stroma      -895.0259 SE0 #> HumanMelanomaPatient1__cell_3674 Stroma      -928.7076 SE0"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/SpatialView.html","id":null,"dir":"Reference","previous_headings":"","what":"Visualize Spatial Landscape of Cells / Spots — SpatialView","title":"Visualize Spatial Landscape of Cells / Spots — SpatialView","text":"Visualize Spatial Landscape Cells / Spots","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/SpatialView.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Visualize Spatial Landscape of Cells / Spots — SpatialView","text":"","code":"SpatialView(   obj,   by,   X = \"X\",   Y = \"Y\",   pt.shape = 20,   pt.size = 0.5,   pt.alpha = 1,   jitter = FALSE,   slot = \"data\",   coord.fix = FALSE,   highlight.cells = NULL,   control.cells = NULL,   ncol = 3,   bg.downsample = 2000,   bg.color = \"gray80\",   bg.size = 0.5,   bg.alpha = 0.7 )"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/SpatialView.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Visualize Spatial Landscape of Cells / Spots — SpatialView","text":"obj Seurat object data frame (cell names row names). feature name plotting, e.g. cell type, region, gene expression. X character specifying spatial coordinate x-axis. Y character specifying spatial coordinate y-axis. pt.shape Point shape plotting pt.size numeric specifying point size non-control cells. pt.alpha numeric specifying point transparency non-control cells. jitter boolean specifying whether add jitters cells. slot slot Seurat object pull feature . highlight.cells vector specifying cells highlighting. control.cells vector specifying control cells background. specified, non-highlighting cells considered control.cells. bg.downsample integer specifying aim downsampling control.cells. bg.color Color control cells. bg.size numeric specifying point size control cells. bg.alpha numeric specifying point transparency control cells.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/SpatialView.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Visualize Spatial Landscape of Cells / Spots — SpatialView","text":"ggplot object.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/SpatialView.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Visualize Spatial Landscape of Cells / Spots — SpatialView","text":"","code":"library(data.table) library(Seurat) library(SpatialEcoTyper) library(ggplot2) library(googledrive) drive_deauth() # no Google sign-in is required drive_download(as_id(\"1CgUOQKrWY_TG61o5aw7J9LZzE20D6NuI\"),                     \"HumanMelanomaPatient1_subset_scmeta.tsv\", overwrite = TRUE) #> File downloaded: #> • HumanMelanomaPatient1_subset_scmeta.tsv #>    #> Saved locally as: #> • HumanMelanomaPatient1_subset_scmeta.tsv scmeta <- fread(\"HumanMelanomaPatient1_subset_scmeta.tsv\",                 sep = \"\\t\",header = TRUE, data.table = FALSE)  # Visualize the cell type annotations in the tissue SpatialView(scmeta, by = \"CellType\", X = \"X\", Y = \"Y\") +             scale_color_manual(values = pals::kelly()[-1]) #> Scale for colour is already present. #> Adding another scale for colour, which will replace the existing scale.  SpatialView(scmeta, by = \"Region\", X = \"X\", Y = \"Y\") +             scale_color_brewer(type = \"qual\", palette = \"Set1\") #> Scale for colour is already present. #> Adding another scale for colour, which will replace the existing scale."},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/Znorm.html","id":null,"dir":"Reference","previous_headings":"","what":"Weighted / Unweighted Uni-variance Normalization — Znorm","title":"Weighted / Unweighted Uni-variance Normalization — Znorm","text":"Z-score normalization scales feature (gene) across cells mean 0 standard deviation 1. function allows optional weighted univariance normalization, cells grouped categorical variable.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/Znorm.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Weighted / Unweighted Uni-variance Normalization — Znorm","text":"","code":"Znorm(mat, groups = NULL)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/Znorm.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Weighted / Unweighted Uni-variance Normalization — Znorm","text":"mat matrix gene expression data, rows represent genes columns represent cells. groups character vector specifying group labels cell. provided, weighted univariance normalization performed.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/Znorm.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Weighted / Unweighted Uni-variance Normalization — Znorm","text":"matrix Z-score normalized gene expression data, rows representing genes columns representing cells.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/Znorm.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Weighted / Unweighted Uni-variance Normalization — Znorm","text":"","code":"library(Seurat) library(data.table) library(SpatialEcoTyper) library(googledrive) drive_deauth() # no Google sign-in is required drive_download(as_id(\"1CoQmU3u8MoVC8RbLUvTDQmOuJJ703HHB\"),               \"HumanMelanomaPatient1_subset_counts.tsv.gz\", overwrite = TRUE) #> File downloaded: #> • HumanMelanomaPatient1_subset_counts.tsv.gz #>    #> Saved locally as: #> • HumanMelanomaPatient1_subset_counts.tsv.gz scdata <- fread(\"HumanMelanomaPatient1_subset_counts.tsv.gz\",                 sep = \"\\t\",header = TRUE, data.table = FALSE) rownames(scdata) <- scdata[, 1] scdata <- as.matrix(scdata[, -1]) tmpobj <- CreateSeuratObject(scdata) %>%           SCTransform(clip.range = c(-10, 10), verbose = FALSE) #> Warning: Data is of class matrix. Coercing to dgCMatrix. seurat_version = as.integer(gsub(\"\\\\..*\", \"\", as.character(packageVersion(\"SeuratObject\")))) if(seurat_version<5){   normdata <- GetAssayData(tmpobj, \"data\") }else{   normdata <- tmpobj[[\"SCT\"]]$data } # Z-score normalization znorm_data <- Znorm(normdata) #> Centering and scaling data matrix head(znorm_data[, 1:5]) #>          HumanMelanomaPatient1__cell_3655 HumanMelanomaPatient1__cell_3657 #> PDK4                           -0.3183628                        2.5919742 #> TNFRSF17                       -0.1060717                       -0.1060717 #> ICAM3                          -0.4436469                       -0.4436469 #> FAP                             3.2256642                       -0.2634737 #> GZMB                           -0.2174644                       -0.2174644 #> TSC2                           -0.1316410                       -0.1316410 #>          HumanMelanomaPatient1__cell_3658 HumanMelanomaPatient1__cell_3660 #> PDK4                            2.5919742                       -0.3183628 #> TNFRSF17                       -0.1060717                       -0.1060717 #> ICAM3                          -0.4436469                       -0.4436469 #> FAP                            -0.2634737                       -0.2634737 #> GZMB                           -0.2174644                       -0.2174644 #> TSC2                           -0.1316410                       -0.1316410 #>          HumanMelanomaPatient1__cell_3661 #> PDK4                           -0.3183628 #> TNFRSF17                       -0.1060717 #> ICAM3                          -0.4436469 #> FAP                            -0.2634737 #> GZMB                           -0.2174644 #> TSC2                           -0.1316410  # Weighted Z-score normalization drive_download(as_id(\"12xcZNhpT-xbhcG8kX1QAdTeM9TKeFAUW\"),                      \"HumanMelanomaPatient1_subset_scmeta.tsv\",                     overwrite = TRUE, verbose = FALSE) #> Warning: The `verbose` argument of `drive_download()` is deprecated as of googledrive #> 2.0.0. #> ℹ Set `options(googledrive_quiet = TRUE)` to suppress all googledrive messages. #> ℹ For finer control, use `local_drive_quiet()` or `with_drive_quiet()`. #> ℹ googledrive's `verbose` argument will be removed in the future. scmeta <- fread(\"HumanMelanomaPatient1_subset_scmeta.tsv\",                 sep = \"\\t\",header = TRUE, data.table = FALSE) wtdznorm_data <- Znorm(normdata, groups = scmeta$Region) head(wtdznorm_data[, 1:5]) #> 6 x 5 Matrix of class \"dgeMatrix\" #>          HumanMelanomaPatient1__cell_3655 HumanMelanomaPatient1__cell_3657 #> PDK4                          -0.27144312                       2.29194978 #> TNFRSF17                      -0.09363659                      -0.09363659 #> ICAM3                         -0.38535691                      -0.38535691 #> FAP                            2.81145245                      -0.22714128 #> GZMB                          -0.19294377                      -0.19294377 #> TSC2                          -0.11586941                      -0.11586941 #>          HumanMelanomaPatient1__cell_3658 HumanMelanomaPatient1__cell_3660 #> PDK4                           2.29194978                      -0.27144312 #> TNFRSF17                      -0.09363659                      -0.09363659 #> ICAM3                         -0.38535691                      -0.38535691 #> FAP                           -0.22714128                      -0.22714128 #> GZMB                          -0.19294377                      -0.19294377 #> TSC2                          -0.11586941                      -0.11586941 #>          HumanMelanomaPatient1__cell_3661 #> PDK4                          -0.27144312 #> TNFRSF17                      -0.09363659 #> ICAM3                         -0.38535691 #> FAP                           -0.22714128 #> GZMB                          -0.19294377 #> TSC2                          -0.11586941"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/dot-Integrate.html","id":null,"dir":"Reference","previous_headings":"","what":"Integrate Spatial Clusters From Multiple Samples Via Similarity Network Fusion — .Integrate","title":"Integrate Spatial Clusters From Multiple Samples Via Similarity Network Fusion — .Integrate","text":"function identifies conserved spatial ecotypes based cell type specific gene expression signature spatial clusters samples.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/dot-Integrate.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Integrate Spatial Clusters From Multiple Samples Via Similarity Network Fusion — .Integrate","text":"","code":".Integrate(   avgexprs,   Region = NULL,   nfeatures = 3000,   min.features = 5,   ncores = 1 )"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/dot-Integrate.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Integrate Spatial Clusters From Multiple Samples Via Similarity Network Fusion — .Integrate","text":"avgexprs Gene expression signature spatial clusters, column represents spatial cluster. Region character vector specifying region annotations spatial clusters. nfeatures Integer specifying maximum number top variable genes select cell type. min.features Integer specifying minimum number shared features (genes) required across samples. ncores Integer specifying number cores parallel processing. Default 1.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/dot-Integrate.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Integrate Spatial Clusters From Multiple Samples Via Similarity Network Fusion — .Integrate","text":"Integrated similarity matrix spatial clusters across samples.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/drawRectangleAnnotation.html","id":null,"dir":"Reference","previous_headings":"","what":"Draw Rectangle Annotations — drawRectangleAnnotation","title":"Draw Rectangle Annotations — drawRectangleAnnotation","text":"function draw rectangle grids based given row column factors.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/drawRectangleAnnotation.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Draw Rectangle Annotations — drawRectangleAnnotation","text":"","code":"drawRectangleAnnotation(rows, columns)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/drawRectangleAnnotation.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Draw Rectangle Annotations — drawRectangleAnnotation","text":"rows vector row identifiers. columns vector column identifiers.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/drawRectangleAnnotation.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Draw Rectangle Annotations — drawRectangleAnnotation","text":"","code":"library(grid) library(SpatialEcoTyper) library(ComplexHeatmap)  dat = matrix(rnorm(100), 10) rownames(dat) = letters[1:10] colnames(dat) = letters[11:20] rowann = data.frame(Group = rep(letters[1:2], each=5), index = 1:10) colann = data.frame(Group = rep(letters[1:2], each=5), index = 11:20) HeatmapView(dat, left_ann = rowann, top_ann = colann) drawRectangleAnnotation(rowann$Group, colann$Group)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/draw_rectangle_annotation.html","id":null,"dir":"Reference","previous_headings":"","what":"Draw Rectangle Annotations — draw_rectangle_annotation","title":"Draw Rectangle Annotations — draw_rectangle_annotation","text":"function draw rectangle grids based given row column factors.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/draw_rectangle_annotation.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Draw Rectangle Annotations — draw_rectangle_annotation","text":"","code":"draw_rectangle_annotation(rows, columns)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/draw_rectangle_annotation.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Draw Rectangle Annotations — draw_rectangle_annotation","text":"rows vector row identifiers. columns vector column identifiers.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/draw_rectangle_annotation.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Draw Rectangle Annotations — draw_rectangle_annotation","text":"","code":"library(grid) library(SpatialEcoTyper) library(ComplexHeatmap)  dat = matrix(rnorm(100), 10) rownames(dat) = letters[1:10] colnames(dat) = letters[11:20] rowann = data.frame(Group = rep(letters[1:2], each=5), index = 1:10) colann = data.frame(Group = rep(letters[1:2], each=5), index = 11:20) HeatmapView(dat, left_ann = rowann, top_ann = colann) draw_rectangle_annotation(rowann$Group, colann$Group)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/fillspots.html","id":null,"dir":"Reference","previous_headings":"","what":"Handle Missing Values — fillspots","title":"Handle Missing Values — fillspots","text":"function fills missing spatial regions similarity network matrices zeros. ensures matrices list set spatial regions.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/fillspots.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Handle Missing Values — fillspots","text":"","code":"fillspots(snlist)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/fillspots.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Handle Missing Values — fillspots","text":"snlist list similarity network matrices rows columns correspond spatial regions.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/fillspots.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Handle Missing Values — fillspots","text":"list similarity network matrices missing spatial regions filled zero values.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/fillspots.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Handle Missing Values — fillspots","text":"function first identifies unique spatial regions across input list matrices. ensures matrix set regions adding missing regions zero similarity values. step crucial downstream analyses require consistent dimensions across samples.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/getColors.html","id":null,"dir":"Reference","previous_headings":"","what":"Generate a List of Colors — getColors","title":"Generate a List of Colors — getColors","text":"function generates list colors based specified number palette type. supports categorical continuous color palettes.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/getColors.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Generate a List of Colors — getColors","text":"","code":"getColors(n, palette = 1, categoric = TRUE, exclude = NULL)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/getColors.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Generate a List of Colors — getColors","text":"n integer specifying number colors required. palette integer specifying color palette use. categorical palettes, valid values 1 7, continuous palettes, valid values 1 14. categoric logical value indicating whether use categorical palettes (TRUE) continuous palettes (FALSE). Default TRUE. exclude character vector colors exclude generated list. Default NULL.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/getColors.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Generate a List of Colors — getColors","text":"vector colors.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/getColors.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Generate a List of Colors — getColors","text":"function uses different sets color palettes categorical continuous data. categorical data, function includes palettes kelly, cols25, polychrome, glasbey, alphabet2, alphabet. continuous data, function includes palettes like viridis, parula, magma, coolwarm, warmcool, inferno, plasma, several kovesi linear palettes. number requested colors exceeds available colors chosen palette, additional colors sampled combined set available colors, ensuring uniqueness generated colors. function uses `setdiff` exclude specified colors ensures colors repeated setting seed reproducibility.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/getColors.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Generate a List of Colors — getColors","text":"","code":"# Generate 5 categorical colors using the first palette getColors(5, palette = 1, categoric = TRUE) #> [1] \"#F3C300\" \"#875692\" \"#F38400\" \"#A1CAF1\" \"#222222\"  # Generate 10 continuous colors using the viridis palette getColors(10, palette = 1, categoric = FALSE) #>  [1] \"#440154\" \"#462777\" \"#3D4988\" \"#30678D\" \"#25818E\" \"#1F9D87\" \"#36B677\" #>  [8] \"#6DCC57\" \"#B3DC2B\" \"#FDE725\""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/matrixMultiply.html","id":null,"dir":"Reference","previous_headings":"","what":"Matrix Multiplication with Minibatching and Parallel Processing — matrixMultiply","title":"Matrix Multiplication with Minibatching and Parallel Processing — matrixMultiply","text":"function performs matrix multiplication two matrices (`mat1` `mat2`) using minibatching manage memory usage parallel processing speed computation. particularly useful large matrices full multiplication otherwise computationally intensive memory prohibitive.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/matrixMultiply.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Matrix Multiplication with Minibatching and Parallel Processing — matrixMultiply","text":"","code":"matrixMultiply(mat1, mat2, minibatch = 5000, ncores = 1)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/matrixMultiply.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Matrix Multiplication with Minibatching and Parallel Processing — matrixMultiply","text":"mat1 matrix dimensions (m x n). mat2 matrix dimensions (n x p). minibatch number columns `mat2` process minibatch. Default 5000. ncores number cores use parallel processing. Default 1 (parallel processing).","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/matrixMultiply.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Matrix Multiplication with Minibatching and Parallel Processing — matrixMultiply","text":"matrix dimensions (m x p) representing product `mat1` `mat2`.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/matrixMultiply.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Matrix Multiplication with Minibatching and Parallel Processing — matrixMultiply","text":"","code":"# Example usage: mat1 <- matrix(runif(1000), nrow=100, ncol=10) mat2 <- matrix(runif(2000), nrow=10, ncol=200) result <- matrixMultiply(mat1, mat2, minibatch=100, ncores=2)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/mostFrequent.html","id":null,"dir":"Reference","previous_headings":"","what":"Identify the most frequent category in a vector — mostFrequent","title":"Identify the most frequent category in a vector — mostFrequent","text":"function takes vector input returns frequent category value. works converting input table frequencies, sorting frequencies descending order, returning common value character string.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/mostFrequent.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Identify the most frequent category in a vector — mostFrequent","text":"","code":"mostFrequent(x)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/mostFrequent.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Identify the most frequent category in a vector — mostFrequent","text":"x vector values (e.g., categorical character data).","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/mostFrequent.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Identify the most frequent category in a vector — mostFrequent","text":"character string representing frequent value input vector.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/nmfClustering.html","id":null,"dir":"Reference","previous_headings":"","what":"Robust Clustering via NMF (non-negative matrix factorization) — nmfClustering","title":"Robust Clustering via NMF (non-negative matrix factorization) — nmfClustering","text":"one rank provided, NMF clustering performed. multiple ranks provided, function determine optimal number communities (K) assessing cophenetic coefficient across different values K.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/nmfClustering.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Robust Clustering via NMF (non-negative matrix factorization) — nmfClustering","text":"","code":"nmfClustering(   mat,   ranks = 10,   nrun.per.rank = 30,   min.coph = 0.95,   nmf.method = \"brunet\",   ncores = 1,   plot = FALSE,   seed = 2024,   ... )"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/nmfClustering.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Robust Clustering via NMF (non-negative matrix factorization) — nmfClustering","text":"mat Numeric matrix representing input data clustering analysis. ranks Numeric vector specifying number clusters evaluate. nrun.per.rank Integer specifying number runs per rank clustering. min.coph Numeric specifying minimum cophenetic coefficient required rank optimal. nmf.method Character string specifying method NMF analysis. ncores Integer specifying number CPU cores use parallel processing. plot Logical indicating whether plot results. seed integer used seed random number generator NMF analysis. ... Additional arguments passed nmf function.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/nmfClustering.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Robust Clustering via NMF (non-negative matrix factorization) — nmfClustering","text":"NMFfitX1 object one rank provided. list containing optimal number communities (bestK), list NMFfitX1 objects (NMFfits), ggplot object (p) displaying cophenetic coefficient across different values K.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/nmfClustering.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Robust Clustering via NMF (non-negative matrix factorization) — nmfClustering","text":"","code":"library(NMF) library(SpatialEcoTyper) mat <- matrix(rnorm(1000, 3), 20) mat[mat<0] = 0  ## Specify one rank result <- nmfClustering(mat = mat, ranks = 3, nrun.per.rank = 3) predict(result) #>  [1] 3 2 2 3 2 2 2 2 3 1 1 1 1 3 1 2 3 3 3 2 2 2 2 1 2 1 3 3 3 3 2 3 1 3 3 2 3 2 #> [39] 1 2 2 3 3 1 3 2 1 3 3 3 #> attr(,\"what\") #> [1] columns #> Levels: 1 2 3  ## Determine optimal ranks by testing multiple ranks result <- nmfClustering(mat = mat, ranks = 2:5, nrun.per.rank = 3) result$p  result$bestK #> [1] 2 predict(result$NMFfits[[paste0(\"K.\", result$bestK)]]) #>  [1] 1 1 2 1 1 1 1 1 2 2 2 2 1 2 2 1 1 2 2 1 1 1 2 2 1 2 1 2 1 1 1 2 2 2 1 1 2 1 #> [39] 2 1 2 1 1 2 2 1 2 2 2 2 #> attr(,\"what\") #> [1] columns #> Levels: 1 2"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/rankSparse.html","id":null,"dir":"Reference","previous_headings":"","what":"Transform a Sparse Matrix to Rank Space (Rank Non-zeros in Each Column) — rankSparse","title":"Transform a Sparse Matrix to Rank Space (Rank Non-zeros in Each Column) — rankSparse","text":"function ranks non-zero elements sparse matrix within column. ranks scaled dividing number rows matrix, resulting ranks normalized 0 1. original zero values left unchanged.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/rankSparse.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Transform a Sparse Matrix to Rank Space (Rank Non-zeros in Each Column) — rankSparse","text":"","code":"rankSparse(sparseMat)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/rankSparse.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Transform a Sparse Matrix to Rank Space (Rank Non-zeros in Each Column) — rankSparse","text":"sparseMat sparse matrix","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/rankSparse.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Transform a Sparse Matrix to Rank Space (Rank Non-zeros in Each Column) — rankSparse","text":"sparse matrix dimensions input, non-zero elements         replaced ranks within column, normalized number rows.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/rankSparse.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Transform a Sparse Matrix to Rank Space (Rank Non-zeros in Each Column) — rankSparse","text":"","code":"library(Matrix) # Create a sample sparse matrix sparseMat <- rsparsematrix(5, 5, density = 0.5) # Apply the ranking function rankedSparseMat <- rankSparse(sparseMat) print(rankedSparseMat) #> 5 x 5 sparse Matrix of class \"dgCMatrix\" #>                          #> [1,] 0.4 .   0.2 .   0.6 #> [2,] 0.6 .   0.4 .   .   #> [3,] 0.2 .   .   0.4 0.2 #> [4,] .   0.2 0.6 .   .   #> [5,] .   .   .   0.2 0.4"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/rank_sparse.html","id":null,"dir":"Reference","previous_headings":"","what":"Transform a sparse matrix to rank space (rank non-zeros in each column) — rank_sparse","title":"Transform a sparse matrix to rank space (rank non-zeros in each column) — rank_sparse","text":"function ranks non-zero elements sparse matrix within column. ranks scaled dividing number rows matrix, resulting ranks normalized 0 1. original zero values left unchanged.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/rank_sparse.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Transform a sparse matrix to rank space (rank non-zeros in each column) — rank_sparse","text":"","code":"rank_sparse(sparseMat)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/rank_sparse.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Transform a sparse matrix to rank space (rank non-zeros in each column) — rank_sparse","text":"sparseMat sparse matrix","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/rank_sparse.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Transform a sparse matrix to rank space (rank non-zeros in each column) — rank_sparse","text":"sparse matrix dimensions input, non-zero elements         replaced ranks within column, normalized number rows.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/rank_sparse.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Transform a sparse matrix to rank space (rank non-zeros in each column) — rank_sparse","text":"","code":"library(Matrix) # Create a sample sparse matrix sparseMat <- rsparsematrix(5, 5, density = 0.5) # Apply the ranking function rankedSparseMat <- rank_sparse(sparseMat) print(rankedSparseMat) #> 5 x 5 sparse Matrix of class \"dgCMatrix\" #>                          #> [1,] 0.4 .   0.2 .   0.6 #> [2,] 0.6 .   0.4 .   .   #> [3,] 0.2 .   .   0.4 0.2 #> [4,] .   0.2 0.6 .   .   #> [5,] .   .   .   0.2 0.4"},{"path":"https://digitalcytometry.github.io/spatialecotyper/news/index.html","id":"spatialecotyper-001","dir":"Changelog","previous_headings":"","what":"SpatialEcoTyper 0.0.1","title":"SpatialEcoTyper 0.0.1","text":"SpatialEcoTyper: SE discovery single sample MultiSpatialEcoTyper: Integrative analysis SEs multiple samples IntegrateSpatialEcoTyper: Integrative analysis SEs multiple samples RecoverSE: SE recovery nmfClustering: NMF clustering SpatialView: draw spatial map tissue HeatmapView: draw heatmap CreatePseudobulks: create pseudobulk mixtures NMFGenerateW: train NMF model SE deconvolution bulk expression profiles NMFGenerateWList: train cell-type specific NMF model SE recovery","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/news/index.html","id":"spatialecotyper-002","dir":"Changelog","previous_headings":"","what":"SpatialEcoTyper 0.0.2","title":"SpatialEcoTyper 0.0.2","text":"Reduce memory usage computing distance spatial neighbors pairwise distances","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/news/index.html","id":"spatialecotyper-003","dir":"Changelog","previous_headings":"","what":"SpatialEcoTyper 0.0.3","title":"SpatialEcoTyper 0.0.3","text":"Reduce memory usage replacing Reduce() loops Add seeds nmfClustering Re-organize documentation integrative analysis Test refine documentations","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/news/index.html","id":"spatialecotyper-004","dir":"Changelog","previous_headings":"","what":"SpatialEcoTyper 0.0.4","title":"SpatialEcoTyper 0.0.4","text":"Test Seurat v4.2, v4.4 v5 analysis add related notes: lead different embedding clustering results, show high consistency (ARI=0.7) demo. Add figures output directory integrative analysis Add hints training SE recovery model: demo less robust due limited number cells used. training data comprehensive possible. Add minibatch option SNF2 function reduce memory usage Add hints memory usage parallel processing","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/news/index.html","id":"spatialecotyper-005","dir":"Changelog","previous_headings":"","what":"SpatialEcoTyper 0.0.5","title":"SpatialEcoTyper 0.0.5","text":"Add filter.region..celltypes option SpatialEcoTyper MultiSpatialEcoTyper","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/news/index.html","id":"spatialecotyper-100","dir":"Changelog","previous_headings":"","what":"SpatialEcoTyper 1.0.0","title":"SpatialEcoTyper 1.0.0","text":"First release","code":""}]
+[{"path":"https://digitalcytometry.github.io/spatialecotyper/LICENSE.html","id":null,"dir":"","previous_headings":"","what":"STANFORD NON-COMMERCIAL SOFTWARE LICENSE AGREEMENT","title":"STANFORD NON-COMMERCIAL SOFTWARE LICENSE AGREEMENT","text":"Board Trustees Leland Stanford Junior University (“Stanford”) provides EcoTyper software code (“Service”) free charge non-commercial use . Use Service commercial entity purpose, including research, prohibited. using Service, agree bound terms Agreement. Please read carefully. agree use Service commercial advantage, course -profit activities. agree use Service behalf organization non-profit organization. Commercial entities wishing use Service contact Stanford University’s Office Technology Licensing reference docket S19-484. SERVICE OFFERED “”, , EXTENT PERMITTED LAW, STANFORD MAKES REPRESENTATIONS EXTENDS WARRANTIES KIND, EITHER EXPRESS IMPLIED. STANFORD SHALL LIABLE CLAIMS DAMAGES RESPECT LOSS CLAIM THIRD PARTY ACCOUNT , ARISING USE SERVICE. HEREBY AGREE DEFEND INDEMNIFY STANFORD, TRUSTEES, EMPLOYEES, OFFICERS, STUDENTS, AGENTS, FACULTY, REPRESENTATIVES, VOLUNTEERS (“STANFORD INDEMNITEES”) LOSS CLAIM ASSERTED STANFORD INDEMNITEES ARISING USE SERVICE. rights expressly granted Agreement reserved retained Stanford licensors content providers. Agreement provides license patent. agree Agreement dispute arising governed laws State California, United States America, applicable agreements negotiated, executed, performed within California. Subject compliance terms conditions set forth Agreement, Stanford grants revocable, non-exclusive, non-transferable right access make use Service.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"overview","dir":"Articles","previous_headings":"","what":"Overview","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"tutorial, illustrate identify conserved spatial ecotypes (SEs) across multiple samples using MultiSpatialEcoTyper function. sample represents single-cell spatial transcriptomics data, including gene expression profile associated single-cell metadata. analyzing single-cell spatial transcriptomics data cancer samples provided Vizgen’s MERSCOPE FFPE Human Immuno-oncology. efficiency, selected subset regions melanoma sample colon cancer sample integrative analysis. can download gene expression profiles single-cell metadata . melanoma sample includes spatial expression data 500 genes across 27,907 cells, colon cancer sample contains data 38,080 cells. samples, cells categorized ten distinct cell types: B cells, CD4+ T cells, CD8+ T cells, NK cells, plasma cells, macrophages, dendritic cells (DC), fibroblasts, endothelial cells, cancer cell origin (CCOs). Due high heterogeneity, CCOs excluded demonstration. cells also annotated four spatial regions, including tumor, inner margin, outer margin, stroma. tumor stroma regions defined based density cancer cells. inner outer margins delineated regions extending 250 μm inside outside tumor boundaries, respectively. addition, assessed distance single cell tumor/stroma interface computing shortest Euclidean distance tumor regions (stromal regions) cells localized stromal region (tumor regions). positive distance used cells localized tumor region, negative distance used cells localized stroma region. First load required packages vignette","code":"suppressPackageStartupMessages(library(dplyr)) suppressPackageStartupMessages(library(ggplot2)) suppressPackageStartupMessages(library(parallel)) suppressPackageStartupMessages(library(Seurat)) suppressPackageStartupMessages(library(data.table)) suppressPackageStartupMessages(library(googledrive)) suppressPackageStartupMessages(library(NMF)) suppressPackageStartupMessages(library(ComplexHeatmap)) library(SpatialEcoTyper)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"loading-data","dir":"Articles","previous_headings":"","what":"Loading data","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"Spatial EcoTyper analysis requires two input data sample: gene expression matrix: rows represent gene names columns represent cell IDs meta data: data frame least three columns, including “X” (X-coordinate), “Y” (Y-coordinate), “CellType” (cell type annotation). row names meta data match column names (cell IDs) expression matrix. First, download demo data Google Drive , load text files R. can use read.table small files data.table::fread larger files. Mtx files can loaded R using ReadMtx function Seurat package.","code":"drive_deauth() # Disable Google sign-in requirement drive_download(as_id(\"1CoQmU3u8MoVC8RbLUvTDQmOuJJ703HHB\"), \"HumanMelanomaPatient1_subset_counts.tsv.gz\", overwrite = TRUE) drive_download(as_id(\"1CgUOQKrWY_TG61o5aw7J9LZzE20D6NuI\"), \"HumanMelanomaPatient1_subset_scmeta.tsv\", overwrite = TRUE) drive_download(as_id(\"1ChwONUjr_yoURodnkDBj68ZUbjdHtmP6\"), \"HumanColonCancerPatient2_subset_counts.tsv.gz\", overwrite = TRUE) drive_download(as_id(\"1CipRjjD7cqzqKO0Yf4LUdsEw1XDzP6JS\"), \"HumanColonCancerPatient2_subset_scmeta.tsv\", overwrite = TRUE) # Load single-cell metadata # Row names should be cell ids. Required columns: X, Y, CellType;  # Recommend a 'Region' column if pathologist region annotations are available scmeta1 <- read.table(\"HumanMelanomaPatient1_subset_scmeta.tsv\",                       sep = \"\\t\", header = TRUE, row.names = 1) scmeta2 <- read.table(\"HumanColonCancerPatient2_subset_scmeta.tsv\",                       sep = \"\\t\", header = TRUE, row.names = 1) head(scmeta1[, c(\"X\", \"Y\", \"CellType\", \"Region\")]) ##                                         X         Y   CellType Region ## HumanMelanomaPatient1__cell_3655 1894.706 -6367.766 Fibroblast Stroma ## HumanMelanomaPatient1__cell_3657 1942.480 -6369.602 Fibroblast Stroma ## HumanMelanomaPatient1__cell_3658 1963.007 -6374.026 Fibroblast Stroma ## HumanMelanomaPatient1__cell_3660 1981.600 -6372.266 Fibroblast Stroma ## HumanMelanomaPatient1__cell_3661 1742.939 -6374.851 Fibroblast Stroma ## HumanMelanomaPatient1__cell_3663 1921.683 -6383.309 Fibroblast Stroma head(scmeta2[, c(\"X\", \"Y\", \"CellType\", \"Region\")]) ##                                            X         Y   CellType       Region ## HumanColonCancerPatient2__cell_1085 5057.912 -1721.871 Macrophage Inner margin ## HumanColonCancerPatient2__cell_1205 5035.339 -1783.352 Macrophage Inner margin ## HumanColonCancerPatient2__cell_1312 5012.093 -1908.390 Macrophage Inner margin ## HumanColonCancerPatient2__cell_1625 5073.743 -1861.740 Macrophage Inner margin ## HumanColonCancerPatient2__cell_1629 5030.235 -1867.441 Macrophage Inner margin ## HumanColonCancerPatient2__cell_1639 5020.448 -1882.751 Macrophage Inner margin # Load single-cell gene expression data. Rows represent gene names and columns represent cell IDs scdata1 <- fread(\"HumanMelanomaPatient1_subset_counts.tsv.gz\",                 sep = \"\\t\",header = TRUE, data.table = FALSE) rownames(scdata1) <- scdata1[, 1]  # Setting the first column as row names scdata1 <- as.matrix(scdata1[, -1]) # Dropping first column  scdata2 <- fread(\"HumanColonCancerPatient2_subset_counts.tsv.gz\",                 sep = \"\\t\",header = TRUE, data.table = FALSE) rownames(scdata2) <- scdata2[, 1] # Setting the first column as row names scdata2 <- as.matrix(scdata2[, -1]) # Dropping first column head(scdata1[,1:5]) ##          HumanMelanomaPatient1__cell_3655 HumanMelanomaPatient1__cell_3657 ## PDK4                                    0                                1 ## TNFRSF17                                0                                0 ## ICAM3                                   0                                0 ## FAP                                     1                                0 ## GZMB                                    0                                0 ## TSC2                                    0                                0 ##          HumanMelanomaPatient1__cell_3658 HumanMelanomaPatient1__cell_3660 ## PDK4                                    1                                0 ## TNFRSF17                                0                                0 ## ICAM3                                   0                                0 ## FAP                                     0                                0 ## GZMB                                    0                                0 ## TSC2                                    0                                0 ##          HumanMelanomaPatient1__cell_3661 ## PDK4                                    0 ## TNFRSF17                                0 ## ICAM3                                   0 ## FAP                                     0 ## GZMB                                    0 ## TSC2                                    0 head(scdata2[,1:5]) ##         HumanColonCancerPatient2__cell_1085 HumanColonCancerPatient2__cell_1205 ## PDK4                                      0                                   0 ## CCL26                                     0                                   0 ## CX3CL1                                    0                                   0 ## PGLYRP1                                   0                                   0 ## CD4                                       0                                   0 ## SNAI2                                     0                                   0 ##         HumanColonCancerPatient2__cell_1312 HumanColonCancerPatient2__cell_1625 ## PDK4                                      1                                   0 ## CCL26                                     0                                   0 ## CX3CL1                                    0                                   0 ## PGLYRP1                                   0                                   0 ## CD4                                       0                                   0 ## SNAI2                                     0                                   0 ##         HumanColonCancerPatient2__cell_1629 ## PDK4                                      0 ## CCL26                                     0 ## CX3CL1                                    0 ## PGLYRP1                                   0 ## CD4                                       0 ## SNAI2                                     0 # Make sure row names of the meta data match column names of the gene expression matrix scdata1 <- scdata1[, match(rownames(scmeta1), colnames(scdata1))] scdata2 <- scdata2[, match(rownames(scmeta2), colnames(scdata2))] drive_download(as_id(\"13M3xhRxp0xK9gf5F4DE9idSBFqVQIXDT\"), \"HumanMelanomaPatient1_subset_counts.mtx.gz\", overwrite = TRUE) drive_download(as_id(\"136feRaFjMtNvduLTm5xqa3WhyyoG4Xzo\"), \"HumanMelanomaPatient1_subset_cells.tsv.gz\", overwrite = TRUE) drive_download(as_id(\"13QprWzJhzzUy_w3XSrjlt9pjf2n-G7HV\"), \"HumanMelanomaPatient1_subset_genes.tsv.gz\", overwrite = TRUE)  drive_download(as_id(\"17fH9BAAugYi1FMLrMuTxojtOoklFBB-K\"), \"HumanColonCancerPatient2_subset_counts.mtx.gz\", overwrite = TRUE) drive_download(as_id(\"17a1f1VjxJSje_uyPt6zA97zTps9ko6rk\"), \"HumanColonCancerPatient2_subset_cells.tsv.gz\", overwrite = TRUE) drive_download(as_id(\"17fH0jE5b2YqJ5fpQtYil27k-7YhzArD6\"), \"HumanColonCancerPatient2_subset_genes.tsv.gz\", overwrite = TRUE) scdata1 <- ReadMtx(mtx = \"HumanMelanomaPatient1_subset_counts.mtx.gz\", cells = \"HumanMelanomaPatient1_subset_cells.tsv.gz\", features = \"HumanMelanomaPatient1_subset_genes.tsv.gz\", feature.column = 1, cell.column = 1) scdata2 <- ReadMtx(mtx = \"HumanColonCancerPatient2_subset_counts.mtx.gz\", cells = \"HumanColonCancerPatient2_subset_cells.tsv.gz\", features = \"HumanColonCancerPatient2_subset_genes.tsv.gz\", feature.column = 1, cell.column = 1)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"data-normalization","dir":"Articles","previous_headings":"","what":"Data normalization","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"Gene expression data normalized SpatialEcoTyper analysis. can achieved using either NormalizeData SCTransform. Alternatively, may skip step allow MultiSpatialEcoTyper function handle normalization specifying desired method (e.g., SCT) normalization.method argument. faster computation, recommended install glmGamPoi package SCTransform normalization.","code":"## Install the glmGamPoi package if(!\"glmGamPoi\" %in% installed.packages()){   BiocManager::install(\"glmGamPoi\") }  ## Data normalization tmpobj1 <- CreateSeuratObject(scdata1) %>%       SCTransform(clip.range = c(-10, 10), verbose = FALSE) tmpobj2 <- CreateSeuratObject(scdata2) %>%       SCTransform(clip.range = c(-10, 10), verbose = FALSE)  ## Extract the normalized gene expression data seurat_version = as.integer(gsub(\"\\\\..*\", \"\", as.character(packageVersion(\"SeuratObject\")))) if(seurat_version<5){   normdata1 <- GetAssayData(tmpobj1, \"data\")   normdata2 <- GetAssayData(tmpobj2, \"data\") }else{   normdata1 <- tmpobj1[[\"SCT\"]]$data   normdata2 <- tmpobj2[[\"SCT\"]]$data } normdata1 <- NormalizeData(scdata1) normdata2 <- NormalizeData(scdata2)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"preview-of-the-samples","dir":"Articles","previous_headings":"","what":"Preview of the samples","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"SpatialView function can used visualize spatial distribution single cells within tissues.  SpatialView function can also used visualize spatial landscape regions samples.  can also visualize continuous characteristics, minimum distance single cell tumor/stroma margin, using SpatialView function. , positive distances indicate cells located within tumor region, negative distances denote cells within stroma.","code":"# Visualize the cell type annotations in the tissue p1 <- SpatialView(scmeta1, by = \"CellType\") + labs(title = \"SKCM\") +         scale_color_manual(values = pals::cols25()) + theme(legend.position = \"none\") p2 <- SpatialView(scmeta2, by = \"CellType\") + labs(title = \"CRC\") +         scale_color_manual(values = pals::cols25()) p1 + p2 # Visualize the regions in the tissue p1 <- SpatialView(scmeta1, by = \"Region\") + labs(title = \"SKCM\") +         scale_color_brewer(type = \"qual\", palette = \"Set1\") +          theme(legend.position = \"none\") p2 <- SpatialView(scmeta2, by = \"Region\") + labs(title = \"CRC\") +         scale_color_brewer(type = \"qual\", palette = \"Set1\") p1 + p2 # Visualize the distance to tumor margin p1 <- SpatialView(scmeta1, by = \"Dist2Interface\") + labs(title = \"SKCM\") +          scale_colour_gradient2(low = \"#5e3c99\", high = \"#e66101\", mid = \"#d9d9d9\", midpoint = 0) +         theme(legend.position = \"none\") p2 <- SpatialView(scmeta2, by = \"Dist2Interface\") + labs(title = \"CRC\") +          scale_colour_gradient2(low = \"#5e3c99\", high = \"#e66101\", mid = \"#d9d9d9\", midpoint = 0) + labs(color = \"Distance to\\ntumor margin\") p1 + p2 ## Visualize gene expression in the tissue gg <- scmeta1 gg$Expression <- normdata1[\"STAT1\", ] p1 <- SpatialView(gg, by = \"Expression\") +    scale_color_viridis_c() + labs(color = \"STAT1\") gg <- scmeta2 gg$Expression <- normdata2[\"STAT1\", ] p2 <- SpatialView(gg, by = \"Expression\") +    scale_color_viridis_c() + labs(color = \"STAT1\") p1 + p2"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"spatial-ecotyper-analysis-across-multiple-samples","dir":"Articles","previous_headings":"","what":"Spatial EcoTyper analysis across multiple samples","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"MultiSpatialEcoTyper function enables integration single-cell spatial transcriptomics data across multiple samples, facilitating identification SEs shared across samples cancer types. analysis performed three stages: Independent Spatial EcoTyper Analysis: Spatial EcoTyper run sample independently identify spatial clusters construct cell-type-specific gene expression profiles spatial clusters. Integration via Similarity Network Fusion: Spatial clusters different samples integrated learn unified embedding using Similarity Network Fusion (Wang et al., 2014). NMF Clustering: Non-negative Matrix Factorization (NMF) applied unified embedding identify conserved SEs across samples. data_list named list expression matrices matrix represents gene expression data sample. columns matrix correspond cells, rows correspond genes. list names match sample names; otherwise, samples named ‘Sample1’, ‘Sample2’, etc. metadata_list named list metadata data frames, data frame contains metadata corresponding cells expression matrices. metadata data frame include least three columns (X, Y, CellType), row names match cell IDs (column names) expression matrix. outdir Directory results saved. Defaults current directory subdirectory named “SpatialEcoTyper_results_” followed current date. normalization.method Method normalizing expression data. Options include “None” (default), “SCT”, methods compatible Seurat’s NormalizeData function. nmf_ranks Integer vector specifying number clusters (10 default). vector provided, function tests ranks selects optimal rank NMF, though may increase computation time. radius Numeric specifying radius (units spatial coordinates) defining spatial neighborhoods around cell. Default 50. minibatch Integer specifying number columns (default: 5000) process minibatch SNF analysis. option splits matrix smaller chunks, thus reducing memory usage. ncores Integer specifying number cores parallel processing (default: 1). can type ?MultiSpatialEcoTyper visualize full manual. Important note: examples , use 10 clusters 5 runs per rank demonstration purposes. select optimal number clusters obtain robust results, can use nmf_ranks argument vector integers test multiple ranks NMF analysis. can also use nmfClustering function rank selection, outlined next section (NMF clustering SpatialEcoTyper).","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"preparing-data","dir":"Articles","previous_headings":"Spatial EcoTyper analysis across multiple samples","what":"Preparing data","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"","code":"data_list <- list(SKCM = normdata1, CRC = normdata2) metadata_list <- list(SKCM = scmeta1, CRC = scmeta2)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"pathologist-region-annotation-unavailable","dir":"Articles","previous_headings":"Spatial EcoTyper analysis across multiple samples","what":"Pathologist region annotation unavailable","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"","code":"MultiSpatialEcoTyper(data_list, metadata_list,                       normalization.method = \"None\", # Normalization method                      nmf_ranks = 10,  # Number of clusters                      nrun.per.rank = 5,  # Recommend 30 or higher for robust results                      ncores = 2) # This demo takes ~3 minutes on a macOS with an Apple M1 Pro chip and 16 GB memory."},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"pathologist-region-annotation-available","dir":"Articles","previous_headings":"Spatial EcoTyper analysis across multiple samples","what":"Pathologist region annotation available","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"region annotations available, recommend include region annotations metadata specify Region MultiSpatialEcoTyper function, improve integration accuracy.","code":"## Annotation of tumor and stroma regions will be considered for the analysis. metadata_list$SKCM$Region2 = metadata_list$SKCM$Region metadata_list$CRC$Region2 = metadata_list$CRC$Region metadata_list$SKCM$Region2 = ifelse(metadata_list$SKCM$Dist2Interface<0, \"Stroma\", \"Tumor\") metadata_list$CRC$Region2 = ifelse(metadata_list$CRC$Dist2Interface<0, \"Stroma\", \"Tumor\") MultiSpatialEcoTyper(data_list, metadata_list,                       normalization.method = \"None\", # Normalization method                      min.cts.per.region = 2, # At least two cell types in each microregion                      nmf_ranks = 10,  # Number of clusters                      nrun.per.rank = 5,  # Recommend 30 or higher for robust results                      Region = \"Region2\", # Use pathologist annotations if available                      ncores = 2) ## This demo takes ~3 minutes to complete on macOS with an Apple M1 Pro chip and 16 GB memory."},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"pathologist-region-annotation-available-2","dir":"Articles","previous_headings":"Spatial EcoTyper analysis across multiple samples","what":"Pathologist region annotation available (2)","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"can specify nmf_ranks argument vector integers test multiple ranks, enabling selection optimal number clusters. ’ve already run SpatialEcoTyper sample, can integrate results directly using IntegrateSpatialEcoTyper. real-world single-cell ST datasets 100,000 cells, analysis can time- memory-intensive. speed process, can increase number cores used (ncores), also increase memory consumption. limited computational memory, several strategies reduce usage. One approach decrease minibatch size reduce number cores (ncores) allocated. However, larger datasets, minimum memory requirement may remain high. Another option increase grid.size, reduces number spatial microregions. can significantly decrease memory usage downsampling ST data, potentially excluding many cells analysis though. ’re interested studying multicellular communities associated specific cell types, can use filter.region..celltypes argument focus microregions containing least one cell specified cell types. example available Discovery Spatial Ecotypes Single Sample. ’re interested regions composed multiple cell types, can use min.cts.per.region argument specify minimum number distinct cell types required microregion included analysis.","code":"## Annotation of tumor and stroma regions will be considered for the analysis. metadata_list$SKCM$Region2 = metadata_list$SKCM$Region metadata_list$CRC$Region2 = metadata_list$CRC$Region metadata_list$SKCM$Region2 = ifelse(metadata_list$SKCM$Dist2Interface<0, \"Stroma\", \"Tumor\") metadata_list$CRC$Region2 = ifelse(metadata_list$CRC$Dist2Interface<0, \"Stroma\", \"Tumor\") MultiSpatialEcoTyper(data_list, metadata_list,                       normalization.method = \"None\", # Normalization method                      nmf_ranks = seq(4,15,2),  # Number of clusters                      nrun.per.rank = 30,  # 30 runs per rank for robust results                      Region = \"Region2\", # Use pathologist annotations                      ncores = 2) ## This demo takes ~16 minutes to complete on macOS with an Apple M1 Pro chip and 16 GB memory. drive_download(as_id(\"126OSOk8sAaxhJID1D3-75bI9S-to9Lkg\"), \"CRC_SpatialEcoTyper_results.rds\", overwrite = TRUE) drive_download(as_id(\"11y0lcpawQAZAvDCnt3tBQsF90Wet0lKe\"), \"SKCM_SpatialEcoTyper_results.rds\", overwrite = TRUE) data_list <- list(SKCM = normdata1, CRC = normdata2) SpatialEcoTyper_list <- list(SKCM = readRDS(\"SKCM_SpatialEcoTyper_results.rds\"),                              CRC = readRDS(\"CRC_SpatialEcoTyper_results.rds\")) IntegrateSpatialEcoTyper(SpatialEcoTyper_list, data_list,                           outdir = \"SpatialEcoTyper_results/\",                          normalization.method = \"None\",                           nmf_ranks = 10, # Number of clusters                          nrun.per.rank = 5,  # recommend 30 or higher for robust results                          Region = \"Region2\", # Use pathologist annotations if available                          ncores = 2) # This demo takes ~3 minutes on a macOS with an Apple M1 Pro chip and 16 GB memory."},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"output-results","dir":"Articles","previous_headings":"","what":"Output results","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"results saved specified directory (outdir) subdirectory named SpatialEcoTyper_results_ followed current date. output files include: (SampleName)_SpatialEcoTyper_results.rds SpatialEcoTyper result sample. MultiSE_integrated_final.rds matrix representing fused similarity matrix spatial clusters across samples. MultiSE_integrated_final_hmap.pdf heatmap visualizing fused similarity matrix spatial clusters, grouped samples SEs. MultiSE_metadata_final.rds Single-cell metadata ‘SE’ column annotating discovered SEs, saved RDS file. MultiSE_metadata_final.tsv MultiSE_metadata_final.rds, saved TSV format. SpatialView_SEs_by_Sample.pdf figure showing spatial landscape SEs across samples. BarView_SEs_Sample_Frac.pdf bar plot showing fraction cells sample represented within SE. BarView_SEs_Region_Frac_Avg.pdf bar plot showing average fraction regions represented within SE. BarView_SEs_CellType_Frac_Avg.pdf bar plot showing average cell type composition within SE. MultiSE_NMF_results.rds NMF result derived nmfClustering function. single rank provided, contains NMFfitX1 object . multiple ranks provided, list containing optimal number communities (bestK), list NMFfitX1 objects (NMFfits), ggplot object (p) displaying cophenetic coefficient different cluster numbers. MultiSE_NMF_Cophenetic_Dynamics.pdf figure showing cophenetic coefficients different numbers clusters, available multiple ranks provided. results demo data can downloaded MultiSpatialEcoTyper_results.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"nmf-clustering","dir":"Articles","previous_headings":"","what":"NMF clustering","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"Spatial EcoTyper uses NMF group spatial clusters multiple samples conserved SEs. determine optimal number clusters, rank, computed cophenetic coefficient, quantifies classification stability given rank (.e., number clusters) ranges 0 1, 1 indicating maximally stability. Typically, rank cophenetic coefficient begins decrease chosen. However, method can challenging cophenetic coefficient exhibits multi-modal shape across different ranks. cases, Spatial EcoTyper analysis, recommend selecting number SEs coefficient drops 0.95 default.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"selecting-the-optimal-rank","dir":"Articles","previous_headings":"NMF clustering","what":"Selecting the optimal rank","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"determine optimal rank, can use nmfClustering function, tests multiple ranks computes cophenetic coefficient . analysis requires fused similarity network matrix (MultiSE_integrated_final.rds) generated previous step. Load files R: Next, test multiple ranks find optimal number SEs. running time step depends data size, number ranks test, number runs per rank, number cores parallel analysis. demonstration, test six different ranks ranging 4 15 5 runs per rank. better understand cophenetic coefficient changes different ranks, can visualize results.  optimal rank determined, can use generate final SE annotations. can add newly defined SEs meta data","code":"## Fused similarity matrix of spatial clusters across all samples outdir = paste0(\"SpatialEcoTyper_results_\", Sys.Date()) integrated = readRDS(file.path(outdir, \"MultiSE_integrated_final.rds\")) dim(integrated) ## [1] 376 376 ## Single-cell metadata with an 'SE' column annotating the discovered SEs finalmeta = readRDS(file.path(outdir, \"MultiSE_metadata_final.rds\")) head(finalmeta[, c(\"Sample\", \"X\", \"Y\", \"CellType\", \"Region\", \"InitSE\", \"SE\")]) ##                                  Sample        X         Y   CellType Region ## HumanMelanomaPatient1__cell_3655   SKCM 1894.706 -6367.766 Fibroblast Stroma ## HumanMelanomaPatient1__cell_3657   SKCM 1942.480 -6369.602 Fibroblast Stroma ## HumanMelanomaPatient1__cell_3658   SKCM 1963.007 -6374.026 Fibroblast Stroma ## HumanMelanomaPatient1__cell_3660   SKCM 1981.600 -6372.266 Fibroblast Stroma ## HumanMelanomaPatient1__cell_3661   SKCM 1742.939 -6374.851 Fibroblast Stroma ## HumanMelanomaPatient1__cell_3663   SKCM 1921.683 -6383.309 Fibroblast Stroma ##                                          InitSE  SE ## HumanMelanomaPatient1__cell_3655 SKCM..InitSE77 SE3 ## HumanMelanomaPatient1__cell_3657 SKCM..InitSE63 SE4 ## HumanMelanomaPatient1__cell_3658 SKCM..InitSE63 SE4 ## HumanMelanomaPatient1__cell_3660 SKCM..InitSE63 SE4 ## HumanMelanomaPatient1__cell_3661 SKCM..InitSE60 SE3 ## HumanMelanomaPatient1__cell_3663 SKCM..InitSE77 SE3 nmf_res <- nmfClustering(integrated, ranks = seq(4,15,2),                          nrun.per.rank = 5, # Recommend 30 or higher                          min.coph = 0.99, # minimum cophenetic coefficient threshold                          ncores = 4,                          seed = 2024) ## This process takes ~3 minutes on a macOS with an Apple M1 Pro chip and 16 GB of memory paste0(\"The selected rank is \", nmf_res$bestK) ## [1] \"The selected rank is 4\" plot(nmf_res$p) ses <- predict(nmf_res$NMFfits[[paste0(\"K.\", nmf_res$bestK)]]) head(ses) ##   SKCM..InitSE1  SKCM..InitSE74 SKCM..InitSE110  SKCM..InitSE16 SKCM..InitSE111  ##               1               2               2               2               2  ##  SKCM..InitSE24  ##               2  ## Levels: 1 2 3 4 finalmeta$SE = paste0(\"SE\", ses[finalmeta$InitSE]) head(finalmeta) ##                                                               CID        X ## HumanMelanomaPatient1__cell_3655 HumanMelanomaPatient1__cell_3655 1894.706 ## HumanMelanomaPatient1__cell_3657 HumanMelanomaPatient1__cell_3657 1942.480 ## HumanMelanomaPatient1__cell_3658 HumanMelanomaPatient1__cell_3658 1963.007 ## HumanMelanomaPatient1__cell_3660 HumanMelanomaPatient1__cell_3660 1981.600 ## HumanMelanomaPatient1__cell_3661 HumanMelanomaPatient1__cell_3661 1742.939 ## HumanMelanomaPatient1__cell_3663 HumanMelanomaPatient1__cell_3663 1921.683 ##                                          Y   CellType CellTypeName Region ## HumanMelanomaPatient1__cell_3655 -6367.766 Fibroblast  Fibroblasts Stroma ## HumanMelanomaPatient1__cell_3657 -6369.602 Fibroblast  Fibroblasts Stroma ## HumanMelanomaPatient1__cell_3658 -6374.026 Fibroblast  Fibroblasts Stroma ## HumanMelanomaPatient1__cell_3660 -6372.266 Fibroblast  Fibroblasts Stroma ## HumanMelanomaPatient1__cell_3661 -6374.851 Fibroblast  Fibroblasts Stroma ## HumanMelanomaPatient1__cell_3663 -6383.309 Fibroblast  Fibroblasts Stroma ##                                  Dist2Interface Region2         InitSE Sample ## HumanMelanomaPatient1__cell_3655      -883.1752  Stroma SKCM..InitSE77   SKCM ## HumanMelanomaPatient1__cell_3657      -894.8463  Stroma SKCM..InitSE63   SKCM ## HumanMelanomaPatient1__cell_3658      -904.1115  Stroma SKCM..InitSE63   SKCM ## HumanMelanomaPatient1__cell_3660      -907.8909  Stroma SKCM..InitSE63   SKCM ## HumanMelanomaPatient1__cell_3661      -874.2712  Stroma SKCM..InitSE60   SKCM ## HumanMelanomaPatient1__cell_3663      -903.6559  Stroma SKCM..InitSE77   SKCM ##                                   SE ## HumanMelanomaPatient1__cell_3655 SE1 ## HumanMelanomaPatient1__cell_3657 SE1 ## HumanMelanomaPatient1__cell_3658 SE1 ## HumanMelanomaPatient1__cell_3660 SE1 ## HumanMelanomaPatient1__cell_3661 SE1 ## HumanMelanomaPatient1__cell_3663 SE1"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"using-a-different-rank","dir":"Articles","previous_headings":"NMF clustering","what":"Using a different rank","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"simply want experiment different rank, can use nmfClustering function. single rank specified, directly returns NMFfit object predicting SE grouping, shown : can add newly defined SEs meta data","code":"nmf_res <- nmfClustering(integrated, ranks = 10, nrun.per.rank = 30,                           seed = 1, ncores = 1) ses <- predict(nmf_res) ## This process takes ~6 minutes on a macOS with an Apple M1 Pro chip and 16 GB of memory finalmeta$SE = paste0(\"SE\", ses[finalmeta$InitSE]) head(finalmeta) ##                                                               CID        X ## HumanMelanomaPatient1__cell_3655 HumanMelanomaPatient1__cell_3655 1894.706 ## HumanMelanomaPatient1__cell_3657 HumanMelanomaPatient1__cell_3657 1942.480 ## HumanMelanomaPatient1__cell_3658 HumanMelanomaPatient1__cell_3658 1963.007 ## HumanMelanomaPatient1__cell_3660 HumanMelanomaPatient1__cell_3660 1981.600 ## HumanMelanomaPatient1__cell_3661 HumanMelanomaPatient1__cell_3661 1742.939 ## HumanMelanomaPatient1__cell_3663 HumanMelanomaPatient1__cell_3663 1921.683 ##                                          Y   CellType CellTypeName Region ## HumanMelanomaPatient1__cell_3655 -6367.766 Fibroblast  Fibroblasts Stroma ## HumanMelanomaPatient1__cell_3657 -6369.602 Fibroblast  Fibroblasts Stroma ## HumanMelanomaPatient1__cell_3658 -6374.026 Fibroblast  Fibroblasts Stroma ## HumanMelanomaPatient1__cell_3660 -6372.266 Fibroblast  Fibroblasts Stroma ## HumanMelanomaPatient1__cell_3661 -6374.851 Fibroblast  Fibroblasts Stroma ## HumanMelanomaPatient1__cell_3663 -6383.309 Fibroblast  Fibroblasts Stroma ##                                  Dist2Interface Region2         InitSE Sample ## HumanMelanomaPatient1__cell_3655      -883.1752  Stroma SKCM..InitSE77   SKCM ## HumanMelanomaPatient1__cell_3657      -894.8463  Stroma SKCM..InitSE63   SKCM ## HumanMelanomaPatient1__cell_3658      -904.1115  Stroma SKCM..InitSE63   SKCM ## HumanMelanomaPatient1__cell_3660      -907.8909  Stroma SKCM..InitSE63   SKCM ## HumanMelanomaPatient1__cell_3661      -874.2712  Stroma SKCM..InitSE60   SKCM ## HumanMelanomaPatient1__cell_3663      -903.6559  Stroma SKCM..InitSE77   SKCM ##                                    SE ## HumanMelanomaPatient1__cell_3655  SE4 ## HumanMelanomaPatient1__cell_3657 SE10 ## HumanMelanomaPatient1__cell_3658 SE10 ## HumanMelanomaPatient1__cell_3660 SE10 ## HumanMelanomaPatient1__cell_3661  SE4 ## HumanMelanomaPatient1__cell_3663  SE4"},{"path":[]},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"visualizing-the-integrated-similarity-matrix","dir":"Articles","previous_headings":"Visualizing SEs","what":"Visualizing the integrated similarity matrix","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"reordering spatial clusters based newly identified SEs, can re-draw heatmap show fused similarity matrix spatial clusters across samples.","code":"ords = names(ses)[order(ses)] integrated = integrated[ords, ords] # reorder the cells ann <- data.frame(Sample = gsub(\"\\\\.\\\\..*\", \"\", rownames(integrated)),                   SE = paste0(\"SE\", ses[ords]),                   row.names = rownames(integrated)) # cell groups SE_cols <- getColors(length(unique(ann$SE)), palette = 1) # colors for SEs names(SE_cols) <- unique(ann$SE) sample_cols <- getColors(length(unique(ann$Sample)), palette = 2) # colors for samples names(sample_cols) <- unique(ann$Sample)  ## draw heatmap HeatmapView(integrated, show_row_names = FALSE, show_column_names = FALSE,             top_ann = ann, top_ann_col = list(Sample = sample_cols, SE = SE_cols)) drawRectangleAnnotation(ann$SE, ann$SE)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"visualizing-ses-in-the-tissue","dir":"Articles","previous_headings":"Visualizing SEs","what":"Visualizing SEs in the tissue","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"examine spatial distribution identified SEs, can use SpatialView function visualize SEs tissues.","code":"SpatialView(finalmeta, by = \"SE\")  + facet_wrap(~Sample, scales = \"free\")"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"association-between-ses-and-pre-annotated-regions","dir":"Articles","previous_headings":"Visualizing SEs","what":"Association between SEs and pre-annotated regions","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"examine enrichment SEs pre-annotated regions, can visualize cell fractions region, SE.","code":"gg <- finalmeta %>% filter(!is.na(SE)) %>% count(SE, Region, Sample) %>%      group_by(Sample, SE) %>% mutate(Frac = n / sum(n)) %>% ## cell type fractions within each sample     group_by(SE, Region) %>% summarise(Frac = mean(Frac)) ## average cell type fractions across all samples ggplot(gg, aes(SE, Frac, fill = Region)) +    geom_bar(stat = \"identity\", position = \"fill\") +    scale_fill_brewer(type = \"qual\", palette = \"Set1\") +   theme_bw(base_size = 14) + coord_flip() +    labs(y = \"Fraction\") gg <- finalmeta %>% filter(!is.na(SE)) %>% count(SE, Region, Sample)  ggplot(gg, aes(SE, n, fill = Region)) +    geom_bar(stat = \"identity\", position = \"fill\") +    scale_fill_brewer(type = \"qual\", palette = \"Set1\") +   facet_wrap(~Sample) +   theme_bw(base_size = 14) + coord_flip() +    labs(y = \"Fraction of regions\")"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"distance-of-ses-to-tumorstroma-interface","dir":"Articles","previous_headings":"Visualizing SEs","what":"Distance of SEs to tumor/stroma interface","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"box plot visualizes distribution distances SEs tumor/stroma interface. Positive distances indicate cells located within tumor region, negative distances denote cells within stroma. SEs ordered median distance, highlighting spatial localization relative tumor/stroma interface.","code":"gg <- finalmeta %>% filter(!is.na(SE)) %>% group_by(Sample, SE) %>%    summarise(Dist2Interface = mean(Dist2Interface)) %>% arrange(Dist2Interface) gg$SE = factor(gg$SE, levels = unique(gg$SE)) ggplot(gg, aes(SE, Dist2Interface)) + geom_boxplot() +    geom_point(aes(color = Sample)) + theme_bw() +    labs(y = \"Distance to tumor/stroma interface (μm)\")"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"cell-type-composition-of-ses","dir":"Articles","previous_headings":"Visualizing SEs","what":"Cell type composition of SEs","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"can visualize cell type composition SEs bar plot. cell type fractions can averaged across two samples. Average cell type composition SEs across samples","code":"gg <- finalmeta %>% filter(!is.na(SE)) %>% count(SE, CellType, Sample) %>%      group_by(Sample, SE) %>% mutate(Frac = n / sum(n)) %>% ## cell type fractions within each sample     group_by(SE, CellType) %>% summarise(Frac = mean(Frac)) ## average cell type fractions across all samples  ggplot(gg, aes(SE, Frac, fill = CellType)) +    geom_bar(stat = \"identity\", position = \"fill\") +   scale_fill_manual(values = pals::cols25()) +   theme_bw(base_size = 14) + coord_flip() +    labs(y = \"Cell type abundance\") gg <- finalmeta %>% filter(!is.na(SE)) %>% count(SE, CellType, Sample)  ggplot(gg, aes(SE, n, fill = CellType)) +    geom_bar(stat = \"identity\", position = \"fill\") +   scale_fill_manual(values = pals::cols25()) +   facet_wrap(~Sample) +   theme_bw(base_size = 14) + coord_flip() +    labs(y = \"Cell type abundance\")"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"identification-of-cell-type-specific-se-markers","dir":"Articles","previous_headings":"","what":"Identification of cell-type-specific SE markers","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"can identify cell-type-specific SE markers differential expression analysis using presto package. example identify fibroblast-specific markers SE.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"de-analysis-within-each-sample","dir":"Articles","previous_headings":"Identification of cell-type-specific SE markers","what":"DE analysis within each sample","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"","code":"require(\"presto\") ## DE analysis within the first sample tmpmeta1 = finalmeta %>% filter(CellType==\"Fibroblast\" & Sample==\"SKCM\" & (!is.na(SE))) tmpdata1 = normdata1[, tmpmeta1$CID] degs1 = wilcoxauc(tmpdata1, tmpmeta1$SE) ## DE analysis within the second sample tmpmeta2 = finalmeta %>% filter(CellType==\"Fibroblast\" & Sample==\"CRC\" & (!is.na(SE))) tmpdata2 = normdata2[, tmpmeta2$CID] degs2 = wilcoxauc(tmpdata2, tmpmeta2$SE) # DE analysis  head(degs1) ##    feature group     avgExpr        logFC statistic       auc         pval ## 1     PDK4  SE10 0.117555097  0.047787757   4701164 0.5269201 2.300787e-09 ## 2 TNFRSF17  SE10 0.000000000  0.000000000   4460984 0.5000000 1.000000e+00 ## 3    ICAM3  SE10 0.000000000  0.000000000   4460984 0.5000000 1.000000e+00 ## 4      FAP  SE10 0.102200894 -0.037071606   4241882 0.4754425 1.963176e-05 ## 5     GZMB  SE10 0.007441764 -0.008093071   4423277 0.4957737 3.439501e-02 ## 6     TSC2  SE10 0.006910210 -0.002427312   4446112 0.4983331 3.257778e-01 ##           padj     pct_in   pct_out ## 1 1.030353e-08 14.2638037  9.003215 ## 2 1.000000e+00  0.0000000  0.000000 ## 3 1.000000e+00  0.0000000  0.000000 ## 4 6.684535e-05 13.3435583 18.269512 ## 5 8.335732e-02  1.0736196  1.914645 ## 6 6.484080e-01  0.9969325  1.330020 head(degs2) ##    feature group    avgExpr       logFC statistic       auc         pval ## 1     PDK4   SE1 0.07290325 -0.08483371  15082423 0.4580113 3.871812e-25 ## 2   CX3CL1   SE1 0.03282075 -0.01465999  16182732 0.4914246 7.090800e-04 ## 3      CD4   SE1 0.00000000  0.00000000  16465120 0.5000000 1.000000e+00 ## 4    SNAI2   SE1 0.35501044  0.11399360  18215060 0.5531408 6.627100e-26 ## 5 TNFRSF17   SE1 0.00000000  0.00000000  16465120 0.5000000 1.000000e+00 ## 6    ICAM3   SE1 0.00000000  0.00000000  16465120 0.5000000 1.000000e+00 ##           padj    pct_in   pct_out ## 1 2.380875e-24  8.921162 17.125293 ## 2 1.848993e-03  4.107884  5.818208 ## 3 1.000000e+00  0.000000  0.000000 ## 4 4.333913e-25 36.431535 26.939403 ## 5 1.000000e+00  0.000000  0.000000 ## 6 1.000000e+00  0.000000  0.000000"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"identifying-conserved-markers-across-samples","dir":"Articles","previous_headings":"Identification of cell-type-specific SE markers","what":"Identifying conserved markers across samples","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"identify markers conserved across different samples, conduct meta-analysis averaging log2 fold changes (log2FC) DE analyses. identify markers specific SE-associated cell state, calculate difference maximum log2FC gene second-highest log2FC:","code":"library(tidyr) degs <- merge(degs1[, c(1,2,4)], degs2[, c(1,2,4)], by = c(\"feature\", \"group\")) degs$AvgLogFC = (degs$logFC.x + degs$logFC.y) / 2 lfcs = degs %>% pivot_wider(id_cols = feature, names_from = group,                              values_from = AvgLogFC) %>% as.data.frame rownames(lfcs) <- lfcs$feature lfcs <- lfcs[, -1] head(lfcs) ##                SE10         SE3         SE4         SE6         SE7         SE8 ## ACKR3    0.04539229 -0.11089193  0.22761738 -0.13915649 -0.16230522  0.05704506 ## ACTA2    0.64868983  0.19121333 -0.28277467 -0.15495698 -0.13060735  0.26294794 ## ADAMTS4 -0.07880286 -0.03558349 -0.10298639  0.15231638  0.14598004 -0.10437673 ## AKT1    -0.11112575 -0.00885807 -0.19659536  0.11531490  0.32156308 -0.09316424 ## AKT2     0.01227246 -0.01219427  0.01067868 -0.01456746  0.01794543 -0.02832473 ## AKT3     0.05820973 -0.05104454 -0.02226315 -0.01922768  0.02741800 -0.03496944 ##                   SE9 ## ACKR3   -2.297758e-02 ## ACTA2   -1.850714e-01 ## ADAMTS4 -3.370712e-03 ## AKT1    -3.274771e-02 ## AKT2    -2.510557e-05 ## AKT3    -2.496374e-02 secondmax = apply(lfcs, 1, function(x){ -sort(-x)[2] }) delta = lfcs - secondmax ## Markers are considered specific if they have a positive delta and a log2FC greater than 0.05: idx = delta>0 & lfcs>0.05 markers = lapply(colnames(lfcs), function(se){   gs = rownames(idx)[idx[, se]]   gs = gs[order(-lfcs[gs, se])]   gs }) names(markers) = colnames(lfcs) markers = markers[lengths(markers)>0] ## Select the top five markers top5 = lapply(markers, function(x){ x[1:min(5, length(x))] }) top5 ## $SE10 ## [1] \"ACTA2\"  \"COL4A1\" \"MYH11\"  \"TGFB3\"  \"TNC\"    ##  ## $SE3 ## [1] \"FN1\"    \"CSF1\"   \"COL5A1\" ##  ## $SE4 ## [1] \"FOS\"     \"PLA2G2A\" \"DUSP1\"   \"EGR1\"    \"FBLN1\"   ##  ## $SE6 ## [1] \"HLA-DRA\" \"BST2\"    \"CXCL9\"   \"STAT1\"   \"SOD2\"    ##  ## $SE7 ## [1] \"PKM\"    \"MMP11\"  \"CTNNB1\" \"TGFBI\"  \"YAP1\"   ##  ## $SE8 ## [1] \"SFRP2\"   \"COL1A1\"  \"SMOC2\"   \"COL11A1\" \"MFAP5\"   ##  ## $SE9 ## [1] \"XBP1\"  \"CXCR4\" \"CCL2\"  \"PTPRC\" \"STAT3\""},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"visualizing-top-se-cell-state-markers","dir":"Articles","previous_headings":"Identification of cell-type-specific SE markers","what":"Visualizing top SE cell state markers","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"","code":"gg = t(scale(t(lfcs[unlist(top5), ]), center = FALSE)) HeatmapView(gg, breaks = c(0, 1, 1.5))"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Integration.html","id":"session-info","dir":"Articles","previous_headings":"","what":"Session info","title":"Discovery of Spatial Ecotypes from Multiple Samples","text":"session info allows users replicate exact environment identify potential discrepancies package versions configurations might causing problems.","code":"sessionInfo() ## R version 4.4.1 (2024-06-14) ## Platform: aarch64-apple-darwin20 ## Running under: macOS 15.1 ##  ## Matrix products: default ## BLAS:   /Library/Frameworks/R.framework/Versions/4.4-arm64/Resources/lib/libRblas.0.dylib  ## LAPACK: /Library/Frameworks/R.framework/Versions/4.4-arm64/Resources/lib/libRlapack.dylib;  LAPACK version 3.12.0 ##  ## locale: ## [1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8 ##  ## time zone: America/Los_Angeles ## tzcode source: internal ##  ## attached base packages: ## [1] grid      parallel  stats     graphics  grDevices utils     datasets  ## [8] methods   base      ##  ## other attached packages: ##  [1] tidyr_1.3.1           presto_1.0.0          Rcpp_1.0.13           ##  [4] pals_1.9              SpatialEcoTyper_1.0.0 RANN_2.6.2            ##  [7] Matrix_1.7-0          ComplexHeatmap_2.20.0 NMF_0.28              ## [10] Biobase_2.64.0        BiocGenerics_0.50.0   cluster_2.1.6         ## [13] rngtools_1.5.2        registry_0.5-1        googledrive_2.1.1     ## [16] data.table_1.16.0     Seurat_5.1.0          SeuratObject_5.0.2    ## [19] sp_2.1-4              ggplot2_3.5.1         dplyr_1.1.4           ##  ## loaded via a namespace (and not attached): ##   [1] RcppAnnoy_0.0.22            splines_4.4.1               ##   [3] later_1.3.2                 tibble_3.2.1                ##   [5] R.oo_1.26.0                 polyclip_1.10-7             ##   [7] fastDummies_1.7.4           lifecycle_1.0.4             ##   [9] doParallel_1.0.17           globals_0.16.3              ##  [11] lattice_0.22-6              MASS_7.3-60.2               ##  [13] magrittr_2.0.3              plotly_4.10.4               ##  [15] sass_0.4.9                  rmarkdown_2.28              ##  [17] jquerylib_0.1.4             yaml_2.3.10                 ##  [19] httpuv_1.6.15               glmGamPoi_1.16.0            ##  [21] sctransform_0.4.1           spam_2.10-0                 ##  [23] spatstat.sparse_3.1-0       reticulate_1.39.0           ##  [25] mapproj_1.2.11              cowplot_1.1.3               ##  [27] pbapply_1.7-2               RColorBrewer_1.1-3          ##  [29] maps_3.4.2                  zlibbioc_1.50.0             ##  [31] abind_1.4-5                 GenomicRanges_1.56.1        ##  [33] Rtsne_0.17                  purrr_1.0.2                 ##  [35] R.utils_2.12.3              GenomeInfoDbData_1.2.12     ##  [37] circlize_0.4.16             IRanges_2.38.1              ##  [39] S4Vectors_0.42.1            ggrepel_0.9.6               ##  [41] irlba_2.3.5.1               listenv_0.9.1               ##  [43] spatstat.utils_3.1-0        goftest_1.2-3               ##  [45] RSpectra_0.16-2             spatstat.random_3.3-1       ##  [47] fitdistrplus_1.2-1          parallelly_1.38.0           ##  [49] DelayedMatrixStats_1.26.0   pkgdown_2.1.0               ##  [51] DelayedArray_0.30.1         leiden_0.4.3.1              ##  [53] codetools_0.2-20            tidyselect_1.2.1            ##  [55] shape_1.4.6.1               farver_2.1.2                ##  [57] UCSC.utils_1.0.0            matrixStats_1.4.1           ##  [59] stats4_4.4.1                spatstat.explore_3.3-2      ##  [61] jsonlite_1.8.8              GetoptLong_1.0.5            ##  [63] progressr_0.14.0            ggridges_0.5.6              ##  [65] survival_3.6-4              iterators_1.0.14            ##  [67] systemfonts_1.1.0           foreach_1.5.2               ##  [69] tools_4.4.1                 ragg_1.3.2                  ##  [71] ica_1.0-3                   glue_1.7.0                  ##  [73] SparseArray_1.4.8           gridExtra_2.3               ##  [75] xfun_0.47                   MatrixGenerics_1.16.0       ##  [77] GenomeInfoDb_1.40.1         withr_3.0.1                 ##  [79] BiocManager_1.30.25         fastmap_1.2.0               ##  [81] fansi_1.0.6                 digest_0.6.37               ##  [83] R6_2.5.1                    mime_0.12                   ##  [85] textshaping_0.4.0           colorspace_2.1-1            ##  [87] scattermore_1.2             tensor_1.5                  ##  [89] dichromat_2.0-0.1           spatstat.data_3.1-2         ##  [91] R.methodsS3_1.8.2           utf8_1.2.4                  ##  [93] generics_0.1.3              S4Arrays_1.4.1              ##  [95] httr_1.4.7                  htmlwidgets_1.6.4           ##  [97] uwot_0.2.2                  pkgconfig_2.0.3             ##  [99] gtable_0.3.5                lmtest_0.9-40               ## [101] XVector_0.44.0              htmltools_0.5.8.1           ## [103] dotCall64_1.1-1             clue_0.3-65                 ## [105] scales_1.3.0                png_0.1-8                   ## [107] spatstat.univar_3.0-1       knitr_1.48                  ## [109] rstudioapi_0.16.0           reshape2_1.4.4              ## [111] rjson_0.2.22                nlme_3.1-164                ## [113] curl_5.2.2                  cachem_1.1.0                ## [115] zoo_1.8-12                  GlobalOptions_0.1.2         ## [117] stringr_1.5.1               KernSmooth_2.23-24          ## [119] miniUI_0.1.1.1              desc_1.4.3                  ## [121] pillar_1.9.0                vctrs_0.6.5                 ## [123] promises_1.3.0              xtable_1.8-4                ## [125] evaluate_0.24.0             magick_2.8.5                ## [127] cli_3.6.3                   compiler_4.4.1              ## [129] rlang_1.1.4                 crayon_1.5.3                ## [131] future.apply_1.11.2         labeling_0.4.3              ## [133] plyr_1.8.9                  fs_1.6.4                    ## [135] stringi_1.8.4               viridisLite_0.4.2           ## [137] deldir_2.0-4                gridBase_0.4-7              ## [139] munsell_0.5.1               lazyeval_0.2.2              ## [141] spatstat.geom_3.3-2         RcppHNSW_0.6.0              ## [143] patchwork_1.2.0             sparseMatrixStats_1.16.0    ## [145] future_1.34.0               shiny_1.9.1                 ## [147] highr_0.11                  SummarizedExperiment_1.34.0 ## [149] ROCR_1.0-11                 gargle_1.5.2                ## [151] igraph_2.0.3                bslib_0.8.0"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_Bulk.html","id":"overview","dir":"Articles","previous_headings":"","what":"Overview","title":"Recovery of Spatial Ecotypes from Bulk Gene Expression Data","text":"tutorial, demonstrate infer spatial ecotype (SE) abundances bulk RNA-seq data. Specifically, infer SE abundances RNA-seq data TCGA melanoma samples. gene expression matrix available SKCM_RNASeqV2.geneExp.tsv, Transcripts Per Million (TPM) matrix obtained PanCanAtlas. First load required packages vignette","code":"suppressPackageStartupMessages(library(googledrive)) suppressPackageStartupMessages(library(Seurat)) suppressPackageStartupMessages(library(data.table)) library(SpatialEcoTyper)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_Bulk.html","id":"loading-bulk-expression-of-tcga-melanoma-samples","dir":"Articles","previous_headings":"","what":"Loading bulk expression of TCGA melanoma samples","title":"Recovery of Spatial Ecotypes from Bulk Gene Expression Data","text":"","code":"drive_deauth() # Disable Google sign-in requirement drive_download(as_id(\"14RwnoxhIkGeLp6GXehmAXLvy8Ii2_COU\"), \"SKCM_RNASeqV2.geneExp.tsv\", overwrite = TRUE) # download data from googledrive bulkdata <- fread(\"SKCM_RNASeqV2.geneExp.tsv\", sep = \"\\t\", data.table = FALSE) rownames(bulkdata) <- bulkdata[, 1] ## Set the first column as row names bulkdata <- bulkdata[, -1] ## Drop the first column head(bulkdata[, 1:5]) ## TPM matrix ##       TCGA.3N.A9WB.06 TCGA.3N.A9WC.06 TCGA.3N.A9WD.06 TCGA.BF.A1PU.01 ## A1BG         381.0660         195.182        360.8790        176.3990 ## A1CF           0.0000           0.000          0.7092          0.0000 ## A2BP1          0.0000           0.000          6.3830          1.2987 ## A2LD1        250.1980         160.755         97.1986        163.2340 ## A2M         2209.5200      169237.000      18257.9000       6716.4500 ## A2ML1          7.2698           0.000          0.0000          7.7922 ##       TCGA.BF.A1PV.01 ## A1BG         216.8470 ## A1CF           0.0000 ## A2BP1          0.0000 ## A2LD1         60.8727 ## A2M         1740.5800 ## A2ML1          0.5977"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_Bulk.html","id":"se-deconvolution","dir":"Articles","previous_headings":"","what":"SE deconvolution","title":"Recovery of Spatial Ecotypes from Bulk Gene Expression Data","text":"DeconvoluteSE function infers SE abundances bulk tissues. Users can choose either use default model, estimates abundance predefined SEs, apply custom model infer abundance newly defined SEs based bulk gene expression data. prediction, gene expression data log2-transformed (max value exceeds 80), followed normalization mean 0 unit variance gene. ensure accurate univariance normalization, minimum sample size 20 recommended. dataset fewer samples, recommend use public datasets reference estimate mean standard deviation default model trained pseudobulk gene expression data predicts abundances nine predefined SEs along nonSE group, primarily includes cancer cells cells associated SEs. predicted SE nonSE abundances sample sum 1, making comparable across samples. Note: 1) SE abundances directly comparable across samples, enabling analysis SE distribution patterns different conditions. 2) Since number cell states varies across SEs, direct abundance comparisons different SEs nonSE group may meaningful. SEs represent distinct spatial multicellular communities, defined unique combination cell states.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_Bulk.html","id":"using-default-model","dir":"Articles","previous_headings":"SE deconvolution","what":"Using default model","title":"Recovery of Spatial Ecotypes from Bulk Gene Expression Data","text":"","code":"sefracs <- DeconvoluteSE(bulkdata, scale = TRUE) head(sefracs) ##                      nonSE        SE1        SE2        SE3        SE4 ## TCGA.3N.A9WB.06 0.19380234 0.05372667 0.16735600 0.12581663 0.07216666 ## TCGA.3N.A9WC.06 0.05293689 0.13901340 0.08427617 0.08372047 0.04243859 ## TCGA.3N.A9WD.06 0.27200075 0.17114795 0.06288761 0.05641549 0.10166721 ## TCGA.BF.A1PU.01 0.16899510 0.13618971 0.06501306 0.09269615 0.17313296 ## TCGA.BF.A1PV.01 0.12078283 0.06921834 0.05970319 0.16813008 0.11059648 ## TCGA.BF.A1PX.01 0.21398415 0.04019509 0.08906215 0.04499893 0.08561680 ##                        SE5          SE6          SE7        SE8        SE9 ## TCGA.3N.A9WB.06 0.06884572 6.495692e-02 4.610809e-03 0.16471168 0.08400658 ## TCGA.3N.A9WC.06 0.05623098 6.781589e-03 3.162253e-01 0.15964259 0.05873404 ## TCGA.3N.A9WD.06 0.02720647 8.345475e-02 9.239064e-02 0.07760029 0.05522884 ## TCGA.BF.A1PU.01 0.13404194 3.330034e-16 3.330034e-16 0.02543647 0.20449461 ## TCGA.BF.A1PV.01 0.14669963 1.677658e-01 1.260194e-03 0.06961553 0.08622790 ## TCGA.BF.A1PX.01 0.09930790 7.771710e-02 1.239738e-01 0.12590726 0.09923685"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_Bulk.html","id":"using-custom-model","dir":"Articles","previous_headings":"SE deconvolution","what":"Using custom model","title":"Recovery of Spatial Ecotypes from Bulk Gene Expression Data","text":"identifying SEs using SpatialEcoTyper MultiSpatialEcoTyper, users can develop Non-Negative Matrix Factorization (NMF) model deconvolve SEs bulk tissue samples, following tutorial . Users can create NMF model deconvolve SEs bulk gene expression data. training data can derived pseudo-bulk mixtures created aggregating single-cell transcriptomics data. tutorial, generate pseudo-bulk mixtures using single-cell RNA-seq data melanoma sample, also featured Recovery Spatial Ecotypes Single-Cell Gene Expression Data. raw count sample available WU2161_counts.tsv SE recovery results available WU2161_RecoveredSEs.tsv. Loading data Note: demonstration purposes, used 1,337 cells grouped SEs create pseudo-bulk mixtures. limited cell number offers basic example, may fully capture diverse characteristics SEs, potentially affecting robustness model training subsequent SE recovery. practice, recommend using comprehensive dataset accurately reflects properties SEs, ensuring training process results reliable recovery model. Creating pseudobulk data CreatePseudobulks function used create pseudo-bulk mixtures single-cell (spatial) transcriptomics data cells grouped SEs. samples cell fractions Gaussian distribution, sets negative fractions 0 re-normalizes fractions sum 1 across SEs. Based resulting fractions, samples 1,000 cells per pseudo-bulk mixture replacement, aggregates transcriptomes non-log linear space, normalize resulting mixture logarithm CPM using Seurat’s NormalizeData. Training NMFGenerateW function used train NMF model SE deconvolution based provided SE fractions gene expression matrix. applying NMF, gene’s expression scaled mean 0 unit variance (recommended). meet non-negativity requirement NMF, expression matrix transformed using posneg method. transformation splits expression matrix two matrices: one containing positive values containing absolute values negative values. two matrices concatenated form final training data NMF model. resulting W matrix can used infer SE sbundances bulk gene expression profiles using DeconvoluteSE function. Deconvolution can use new model SE deconvolution specifying W parameter:","code":"# Download single-cell gene expression matrix and SE recovery results. # The downloads should be finished within 1min. drive_download(as_id(\"17VAeOnz6vTt2s0ZeTrK1kITdJ3Yus4ei\"), \"WU2161_counts.tsv\", overwrite = TRUE) drive_download(as_id(\"17kFjOHhmWxWAKm-LDqy6wV27o5lvz8L2\"), \"WU2161_RecoveredSEs.tsv\", overwrite = TRUE) # Load single-cell gene expression matrix. counts = fread(\"WU2161_counts.tsv\", sep = \"\\t\", data.table = FALSE) rownames(counts) = counts[, 1] ## Set the first column as row names counts = counts[, -1] ## Drop the first column head(counts[, 1:5])  # Load SE recovery results SEs = read.table(\"WU2161_RecoveredSEs.tsv\", sep = \"\\t\", row.names = 1, header = TRUE) SEs = SEs[match(colnames(counts), rownames(SEs)), 1] # extract SE predictions length(SEs) table(SEs) result = CreatePseudobulks(counts = counts, groups = SEs, n_mixtures = 100) head(result$Mixtures[, 1:5]) ## Gene expression matrix of pseudobulks head(result$Fracs) ## SE fractions in pseudobulks W = NMFGenerateW(t(result$Fracs), result$Mixtures) ## This step should be done within 1 min head(W) sefracs <- DeconvoluteSE(bulkdata, W = W)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_Bulk.html","id":"visualization-of-se-abundances","dir":"Articles","previous_headings":"","what":"Visualization of SE abundances","title":"Recovery of Spatial Ecotypes from Bulk Gene Expression Data","text":"","code":"library(grid) HeatmapView(sefracs, breaks = c(0, 0.15, 0.3),              show_row_names = FALSE, cluster_rows = TRUE)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_Bulk.html","id":"session-info","dir":"Articles","previous_headings":"","what":"Session info","title":"Recovery of Spatial Ecotypes from Bulk Gene Expression Data","text":"session info allows users replicate exact environment identify potential discrepancies package versions configurations might causing problems.","code":"sessionInfo() ## R version 4.4.1 (2024-06-14) ## Platform: aarch64-apple-darwin20 ## Running under: macOS 15.1 ##  ## Matrix products: default ## BLAS:   /Library/Frameworks/R.framework/Versions/4.4-arm64/Resources/lib/libRblas.0.dylib  ## LAPACK: /Library/Frameworks/R.framework/Versions/4.4-arm64/Resources/lib/libRlapack.dylib;  LAPACK version 3.12.0 ##  ## locale: ## [1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8 ##  ## time zone: America/Los_Angeles ## tzcode source: internal ##  ## attached base packages: ## [1] grid      parallel  stats     graphics  grDevices utils     datasets  ## [8] methods   base      ##  ## other attached packages: ##  [1] SpatialEcoTyper_1.0.0 NMF_0.28              Biobase_2.64.0        ##  [4] BiocGenerics_0.50.0   cluster_2.1.6         rngtools_1.5.2        ##  [7] registry_0.5-1        dplyr_1.1.4           RANN_2.6.2            ## [10] Matrix_1.7-0          data.table_1.16.0     Seurat_5.1.0          ## [13] SeuratObject_5.0.2    sp_2.1-4              googledrive_2.1.1     ##  ## loaded via a namespace (and not attached): ##   [1] RColorBrewer_1.1-3     shape_1.4.6.1          rstudioapi_0.16.0      ##   [4] jsonlite_1.8.8         magrittr_2.0.3         magick_2.8.5           ##   [7] spatstat.utils_3.1-0   rmarkdown_2.28         GlobalOptions_0.1.2    ##  [10] fs_1.6.4               ragg_1.3.2             vctrs_0.6.5            ##  [13] ROCR_1.0-11            spatstat.explore_3.3-2 htmltools_0.5.8.1      ##  [16] curl_5.2.2             sass_0.4.9             sctransform_0.4.1      ##  [19] parallelly_1.38.0      KernSmooth_2.23-24     bslib_0.8.0            ##  [22] htmlwidgets_1.6.4      desc_1.4.3             ica_1.0-3              ##  [25] plyr_1.8.9             plotly_4.10.4          zoo_1.8-12             ##  [28] cachem_1.1.0           igraph_2.0.3           iterators_1.0.14       ##  [31] mime_0.12              lifecycle_1.0.4        pkgconfig_2.0.3        ##  [34] R6_2.5.1               fastmap_1.2.0          clue_0.3-65            ##  [37] fitdistrplus_1.2-1     future_1.34.0          shiny_1.9.1            ##  [40] digest_0.6.37          colorspace_2.1-1       S4Vectors_0.42.1       ##  [43] patchwork_1.2.0        tensor_1.5             RSpectra_0.16-2        ##  [46] irlba_2.3.5.1          textshaping_0.4.0      progressr_0.14.0       ##  [49] fansi_1.0.6            spatstat.sparse_3.1-0  httr_1.4.7             ##  [52] polyclip_1.10-7        abind_1.4-5            compiler_4.4.1         ##  [55] gargle_1.5.2           doParallel_1.0.17      fastDummies_1.7.4      ##  [58] highr_0.11             MASS_7.3-60.2          rjson_0.2.22           ##  [61] tools_4.4.1            lmtest_0.9-40          httpuv_1.6.15          ##  [64] future.apply_1.11.2    goftest_1.2-3          glue_1.7.0             ##  [67] nlme_3.1-164           promises_1.3.0         gridBase_0.4-7         ##  [70] Rtsne_0.17             reshape2_1.4.4         generics_0.1.3         ##  [73] gtable_0.3.5           spatstat.data_3.1-2    tidyr_1.3.1            ##  [76] utf8_1.2.4             spatstat.geom_3.3-2    RcppAnnoy_0.0.22       ##  [79] foreach_1.5.2          ggrepel_0.9.6          pillar_1.9.0           ##  [82] stringr_1.5.1          spam_2.10-0            RcppHNSW_0.6.0         ##  [85] later_1.3.2            circlize_0.4.16        splines_4.4.1          ##  [88] lattice_0.22-6         survival_3.6-4         deldir_2.0-4           ##  [91] tidyselect_1.2.1       ComplexHeatmap_2.20.0  miniUI_0.1.1.1         ##  [94] pbapply_1.7-2          knitr_1.48             gridExtra_2.3          ##  [97] IRanges_2.38.1         scattermore_1.2        stats4_4.4.1           ## [100] xfun_0.47              matrixStats_1.4.1      stringi_1.8.4          ## [103] lazyeval_0.2.2         yaml_2.3.10            evaluate_0.24.0        ## [106] codetools_0.2-20       tibble_3.2.1           BiocManager_1.30.25    ## [109] cli_3.6.3              uwot_0.2.2             xtable_1.8-4           ## [112] reticulate_1.39.0      systemfonts_1.1.0      munsell_0.5.1          ## [115] jquerylib_0.1.4        Rcpp_1.0.13            globals_0.16.3         ## [118] spatstat.random_3.3-1  png_0.1-8              spatstat.univar_3.0-1  ## [121] pkgdown_2.1.0          ggplot2_3.5.1          dotCall64_1.1-1        ## [124] listenv_0.9.1          viridisLite_0.4.2      scales_1.3.0           ## [127] ggridges_0.5.6         crayon_1.5.3           leiden_0.4.3.1         ## [130] purrr_1.0.2            GetoptLong_1.0.5       rlang_1.1.4            ## [133] cowplot_1.1.3"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_Spatial.html","id":"se-recovery-from-single-cell-spatial-data","dir":"Articles","previous_headings":"","what":"SE recovery from single-cell spatial data","title":"Recovery of Spatial Ecotypes from Spatial Transcriptomics Data","text":"tutorial, demonstrate recover spatial ecotypes (SEs) single-cell spatial transcriptomics data profiled platforms MERSCOPE, CosMx SMI, Xenium. use subset melanoma MERSCOPE sample illustrate SE recovery process. expression data single-cell metadata can downloaded Google Drive. data, single cells categorized nine major cell types, including B cells, CD4+ T cells, CD8+ T cells, NK cells, plasma cells, macrophages, dendritic cells (DC), fibroblasts, endothelial cells. First load required packages vignette","code":"suppressPackageStartupMessages(library(dplyr)) suppressPackageStartupMessages(library(ggplot2)) suppressPackageStartupMessages(library(Seurat)) suppressPackageStartupMessages(library(data.table)) suppressPackageStartupMessages(library(googledrive)) library(SpatialEcoTyper)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_Spatial.html","id":"loading-data","dir":"Articles","previous_headings":"SE recovery from single-cell spatial data","what":"Loading data","title":"Recovery of Spatial Ecotypes from Spatial Transcriptomics Data","text":"Download demo data Google Drive: Load gene expression matrix meta data R.","code":"drive_deauth() # Disable Google sign-in requirement drive_download(as_id(\"13Rc5Rsu8jbnEYYfUse-xQ7ges51LcI7n\"), \"HumanMelanomaPatient1_subset_counts.tsv.gz\", overwrite = TRUE) drive_download(as_id(\"12xcZNhpT-xbhcG8kX1QAdTeM9TKeFAUW\"), \"HumanMelanomaPatient1_subset_scmeta.tsv\", overwrite = TRUE) # Load single-cell gene expression matrix. Rows are genes, columns are cells. scdata <- fread(\"HumanMelanomaPatient1_subset_counts.tsv.gz\",                  sep = \"\\t\",header = TRUE, data.table = FALSE) rownames(scdata) <- scdata[, 1] scdata <- as.matrix(scdata[, -1]) head(scdata[, 1:5]) ##          HumanMelanomaPatient1__cell_3655 HumanMelanomaPatient1__cell_3657 ## PDK4                                    0                                1 ## TNFRSF17                                0                                0 ## ICAM3                                   0                                0 ## FAP                                     1                                0 ## GZMB                                    0                                0 ## TSC2                                    0                                0 ##          HumanMelanomaPatient1__cell_3658 HumanMelanomaPatient1__cell_3660 ## PDK4                                    1                                0 ## TNFRSF17                                0                                0 ## ICAM3                                   0                                0 ## FAP                                     0                                0 ## GZMB                                    0                                0 ## TSC2                                    0                                0 ##          HumanMelanomaPatient1__cell_3661 ## PDK4                                    0 ## TNFRSF17                                0 ## ICAM3                                   0 ## FAP                                     0 ## GZMB                                    0 ## TSC2                                    0 # Load single-cell metadata, with at least three columns, including X, Y, and CellType scmeta <- read.table(\"HumanMelanomaPatient1_subset_scmeta.tsv\",                        sep = \"\\t\",header = TRUE, row.names = 1) scdata = scdata[, match(rownames(scmeta), colnames(scdata))]  head(scmeta[, c(\"X\", \"Y\", \"CellType\")]) ##                                         X         Y   CellType ## HumanMelanomaPatient1__cell_3655 1894.706 -6367.766 Fibroblast ## HumanMelanomaPatient1__cell_3657 1942.480 -6369.602 Fibroblast ## HumanMelanomaPatient1__cell_3658 1963.007 -6374.026 Fibroblast ## HumanMelanomaPatient1__cell_3660 1981.600 -6372.266 Fibroblast ## HumanMelanomaPatient1__cell_3661 1742.939 -6374.851 Fibroblast ## HumanMelanomaPatient1__cell_3663 1921.683 -6383.309 Fibroblast"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_Spatial.html","id":"data-normalization","dir":"Articles","previous_headings":"SE recovery from single-cell spatial data","what":"Data normalization","title":"Recovery of Spatial Ecotypes from Spatial Transcriptomics Data","text":"gene expression data normalized SE recovery. data can normalized using SCTransform NormalizeData. , normalizing using SCTransform normalization. recommend install glmGamPoi package faster computation.","code":"if(!\"glmGamPoi\" %in% installed.packages()){   BiocManager::install(\"glmGamPoi\") } tmpobj <- CreateSeuratObject(scdata) %>%       SCTransform(clip.range = c(-10, 10), verbose = FALSE)  seurat_version = as.integer(gsub(\"\\\\..*\", \"\", as.character(packageVersion(\"SeuratObject\")))) if(seurat_version<5){   normdata <- GetAssayData(tmpobj, \"data\") }else{   normdata <- tmpobj[[\"SCT\"]]$data } normdata <- NormalizeData(scdata)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_Spatial.html","id":"se-recovery","dir":"Articles","previous_headings":"SE recovery from single-cell spatial data","what":"SE recovery","title":"Recovery of Spatial Ecotypes from Spatial Transcriptomics Data","text":"RecoverSE function used assign single cells SEs. Users can either use default models recover predefined SEs use custom models recover newly defined SEs. Note: recover SEs single-cell data, must specify either celltypes se_results RecoverSE function. neither provided, assume input data represents spot-level spatial transcriptomics, SE abundances inferred directly spot. default NMF models trained discovery MERSCOPE data, encompassing five cancer types: melanoma, four carcinomas. models tailored nine distinct cell types: B cells, CD4+ T cells, CD8+ T cells, NK cells, plasma cells, macrophages, dendritic cells, fibroblasts, endothelial cells. model facilitates recovery SEs single-cell datasets, allowing cell-type-specific SE analysis. Thus, SE recovery using default models, cells query data grouped one “B”, “CD4T”, “CD8T”, “NK”, “Plasma”, “Macrophage”, “DC”, “Fibroblast”, “Endothelial”, case sensitive. cell types considered non-SE compartments. SE recovery, recommend use unified embedding spatial microregions performing de novo Spatial EcoTyper analysis, integrate gene expression spatial information. embedding enhance accuracy refinement SE recovery results. detailed tutorial Spatial EcoTyper analysis available Discovery Spatial Ecotypes Single-cell Spatial Dataset. demonstration purposes, used SpatialEcoTyper group cells spatial clusters resolution 10. practice, recommend experimenting multiple resolutions ensure robust reliable results. specify se_results RecoverSE function SE recovery. can also recover SEs without using spatial embedding, less accurate due lack spatial information. cell type annotations required case. Cells grouped one “B”, “CD4T”, “CD8T”, “NK”, “Plasma”, “Macrophage”, “DC”, “Fibroblast”, “Endothelial”, case sensitive. cell types considered non-SE compartments. use custom models, users first develop recovery models following tutorial Development SE Recovery Models. resulting models can used SE recovery. example model available SE_Recovery_W_list.rds. Using custom models specifying Ws argument:","code":"## make sure the cells are grouped into one of \"B\", \"CD4T\", \"CD8T\", \"NK\", \"Plasma\", \"Macrophage\", \"DC\", \"Fibroblast\", and \"Endothelial\". print(unique(scmeta$CellType)) ## [1] \"Fibroblast\"  \"Endothelial\" \"DC\"          \"Macrophage\"  \"CD8T\"        ## [6] \"CD4T\"        \"Plasma\"      \"NK\"          \"B\" ## Spatial EcoTyper analysis: it would take ~2 min emb = SpatialEcoTyper(normdata, scmeta, resolution = 10) emb$obj ## A seurat object including the spatial embedding ## An object of class Seurat  ## 2315 features across 2315 samples within 1 assay  ## Active assay: RNA (2315 features, 2315 variable features) ##  3 layers present: counts, data, scale.data ##  2 dimensional reductions calculated: pca, umap head(emb$metadata[, c(\"X\", \"Y\", \"CellType\", \"SE\")])  ## Single-cell meta data with SE annotations ##                                         X         Y   CellType   SE ## HumanMelanomaPatient1__cell_3655 1894.706 -6367.766 Fibroblast SE25 ## HumanMelanomaPatient1__cell_3657 1942.480 -6369.602 Fibroblast SE29 ## HumanMelanomaPatient1__cell_3658 1963.007 -6374.026 Fibroblast SE29 ## HumanMelanomaPatient1__cell_3660 1981.600 -6372.266 Fibroblast SE29 ## HumanMelanomaPatient1__cell_3661 1742.939 -6374.851 Fibroblast SE48 ## HumanMelanomaPatient1__cell_3663 1921.683 -6383.309 Fibroblast SE25 sepreds <- RecoverSE(normdata, se_results = emb) head(sepreds) ## HumanMelanomaPatient1__cell_3655 HumanMelanomaPatient1__cell_3657  ##                            \"SE1\"                            \"SE4\"  ## HumanMelanomaPatient1__cell_3658 HumanMelanomaPatient1__cell_3660  ##                            \"SE4\"                            \"SE4\"  ## HumanMelanomaPatient1__cell_3661 HumanMelanomaPatient1__cell_3663  ##                            \"SE3\"                            \"SE1\" ## make sure the cells are grouped into one of \"B\", \"CD4T\", \"CD8T\", \"NK\", \"Plasma\", \"Macrophage\", \"DC\", \"Fibroblast\", and \"Endothelial\". print(unique(scmeta$CellType)) sepreds <- RecoverSE(normdata, celltypes = scmeta$CellType) head(sepreds) # Download SE recovery model drive_download(as_id(\"171WaAe49babYB85Cn1FcoNNE-lzYp1T_\"), \"SE_Recovery_W_list.rds\", overwrite = TRUE) Ws <- readRDS(\"SE_Recovery_W_list.rds\") ## make sure the cell type names are consistent. print(unique(scmeta$CellType)) print(names(Ws)) sepreds <- RecoverSE(normdata, celltypes = scmeta$CellType, Ws = Ws)  ## If Spatial EcoTyper result is available, we recommend: sepreds <- RecoverSE(normdata, se_results = emb, Ws = Ws)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_Spatial.html","id":"visualization-of-ses-in-the-tissue","dir":"Articles","previous_headings":"SE recovery from single-cell spatial data","what":"Visualization of SEs in the tissue","title":"Recovery of Spatial Ecotypes from Spatial Transcriptomics Data","text":"","code":"## Add the recovery result into the meta data scmeta$RecoveredSE <- sepreds[rownames(scmeta)] ## Visualize the SE recovery results SpatialView(scmeta, by = \"RecoveredSE\")"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_Spatial.html","id":"recovery-of-spatial-ecotypes-from-visium-spatial-gene-expression-data","dir":"Articles","previous_headings":"","what":"Recovery of spatial ecotypes from Visium Spatial Gene Expression data","title":"Recovery of Spatial Ecotypes from Spatial Transcriptomics Data","text":"recover SEs Visium spatial transcriptomics data, first infer SE abundances spot. spot assigned SE highest inferred abundance, enabling spatial mapping SEs across tissue. tutorial, use breast cancer sample demonstrate SE recovery Visium data. expression data can accessed : V1_Breast_Cancer_Block_A_Section_1_filtered_feature_bc_matrix.h5, downloaded 10x Genomics datasets.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_Spatial.html","id":"loading-data-1","dir":"Articles","previous_headings":"Recovery of spatial ecotypes from Visium Spatial Gene Expression data","what":"Loading data","title":"Recovery of Spatial Ecotypes from Spatial Transcriptomics Data","text":"First, download data Google Drive Load expression data R using Read10X_h5 function Seurat package.","code":"drive_download(as_id(\"15D9LgvZmCZUfsL62cD67JMf8Jcq_UyuB\"), \"V1_Breast_Cancer_Block_A_Section_1_filtered_feature_bc_matrix.h5\", overwrite = TRUE) drive_download(as_id(\"15NTZc1HrW_gLS_pmi1ckYLw30kNarf4w\"), \"V1_Breast_Cancer_Block_A_Section_1_tissue_positions_list.csv\", overwrite = TRUE) ## This download should be done within 1 min. if(!\"hdf5r\" %in% installed.packages()) BiocManager::install(\"hdf5r\") require(\"hdf5r\") # Load Visium gene expression matrix. Rows are genes, columns are spots. dat <- Read10X_h5(\"V1_Breast_Cancer_Block_A_Section_1_filtered_feature_bc_matrix.h5\") # normalize the expression data dat <- NormalizeData(dat)  meta <- read.csv(\"V1_Breast_Cancer_Block_A_Section_1_tissue_positions_list.csv\",                   header = FALSE, row.names = 1) colnames(meta) <- c(\"tissue\", \"row\", \"col\", \"imagerow\", \"imagecol\") meta <- meta[colnames(dat), ] head(meta) ##                    tissue row col imagerow imagecol ## AAACAAGTATCTCCCA-1      1  50 102    15632    17782 ## AAACACCAATAACTGC-1      1  59  19    17734     6447 ## AAACAGAGCGACTCCT-1      1  14  94     7079    16716 ## AAACAGGGTCTATATT-1      1  47  13    14882     5637 ## AAACAGTGTTCCTGGG-1      1  73  43    21069     9712 ## AAACATTTCCCGGATT-1      1  61  97    18242    17091"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_Spatial.html","id":"se-recovery-1","dir":"Articles","previous_headings":"Recovery of spatial ecotypes from Visium Spatial Gene Expression data","what":"SE recovery","title":"Recovery of Spatial Ecotypes from Spatial Transcriptomics Data","text":"neither celltypes se_results specified, RecoverSE function assume input data gene--spot gene expression matrix infer SE abundances across spots. Users option either use default models recover predefined SEs apply custom models recover newly defined SEs. develop SE recovery models, users follow tutorial Developing SE Recovery Models. resulting models can used SE recovery. example model available SE_Recovery_W_list.rds. specifying Ws parameter (list cell-type-specific W matrices) RecoverSE function, custom models used recovering SEs.","code":"preds <- RecoverSE(dat) head(preds) ##                             SE1          SE2          SE3          SE4 ## AAACAAGTATCTCCCA-1 2.127701e-04 6.877800e-05 3.979458e-01 8.534547e-02 ## AAACACCAATAACTGC-1 1.321616e-01 6.347672e-02 4.580604e-02 9.893653e-02 ## AAACAGAGCGACTCCT-1 1.658118e-01 2.438595e-15 1.257332e-01 1.021615e-01 ## AAACAGGGTCTATATT-1 6.495088e-02 1.975689e-16 2.208619e-01 6.972421e-10 ## AAACAGTGTTCCTGGG-1 9.104830e-02 2.073793e-01 2.579438e-09 6.489594e-02 ## AAACATTTCCCGGATT-1 6.684999e-13 2.987802e-01 2.908525e-08 7.202254e-07 ##                             SE5          SE6          SE7          SE8 ## AAACAAGTATCTCCCA-1 1.162860e-01 1.723712e-16 3.026670e-01 2.078080e-02 ## AAACACCAATAACTGC-1 4.542600e-07 4.511416e-01 3.746409e-16 1.333849e-01 ## AAACAGAGCGACTCCT-1 7.829883e-03 3.928577e-05 3.462729e-01 2.635185e-04 ## AAACAGGGTCTATATT-1 8.604433e-03 1.976922e-16 7.055828e-01 1.739479e-09 ## AAACAGTGTTCCTGGG-1 1.529680e-06 2.947065e-01 2.356171e-15 1.632831e-01 ## AAACATTTCCCGGATT-1 1.993179e-11 1.996192e-01 3.022784e-16 2.576151e-01 ##                             SE9        nonSE ## AAACAAGTATCTCCCA-1 1.755819e-02 5.913523e-02 ## AAACACCAATAACTGC-1 4.131729e-03 7.096041e-02 ## AAACAGAGCGACTCCT-1 1.684507e-02 2.350429e-01 ## AAACAGGGTCTATATT-1 1.975689e-16 2.054490e-11 ## AAACAGTGTTCCTGGG-1 2.351639e-06 1.786829e-01 ## AAACATTTCCCGGATT-1 7.419167e-02 1.697931e-01 ## This step would take ~3 minutes to complete # Download SE recovery model drive_download(as_id(\"171WaAe49babYB85Cn1FcoNNE-lzYp1T_\"), \"SE_Recovery_W_list.rds\", overwrite = TRUE) Ws <- readRDS(\"SE_Recovery_W_list.rds\")  ## Using custom models by specifying the Ws argument preds <- RecoverSE(normdata, Ws = Ws) ## This step would take ~3 minutes to complete"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_Spatial.html","id":"visualization-of-ses-in-the-tissue-1","dir":"Articles","previous_headings":"Recovery of spatial ecotypes from Visium Spatial Gene Expression data","what":"Visualization of SEs in the tissue","title":"Recovery of Spatial Ecotypes from Spatial Transcriptomics Data","text":"spot can assigned SE highest inferred abundance, spatial mapping SEs can visualized using SpatialView function.","code":"meta$RecoveredSE = colnames(preds)[apply(preds, 1, which.max)] meta$Y = -meta$row SpatialView(meta, by = \"RecoveredSE\", X = \"col\", Y = \"Y\", pt.size = 2)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_Spatial.html","id":"session-info","dir":"Articles","previous_headings":"","what":"Session info","title":"Recovery of Spatial Ecotypes from Spatial Transcriptomics Data","text":"session info allows users replicate exact environment identify potential discrepancies package versions configurations might causing problems.","code":"sessionInfo() ## R version 4.4.1 (2024-06-14) ## Platform: aarch64-apple-darwin20 ## Running under: macOS 15.1 ##  ## Matrix products: default ## BLAS:   /Library/Frameworks/R.framework/Versions/4.4-arm64/Resources/lib/libRblas.0.dylib  ## LAPACK: /Library/Frameworks/R.framework/Versions/4.4-arm64/Resources/lib/libRlapack.dylib;  LAPACK version 3.12.0 ##  ## locale: ## [1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8 ##  ## time zone: America/Los_Angeles ## tzcode source: internal ##  ## attached base packages: ## [1] parallel  stats     graphics  grDevices utils     datasets  methods   ## [8] base      ##  ## other attached packages: ##  [1] hdf5r_1.3.11          SpatialEcoTyper_1.0.0 NMF_0.28              ##  [4] Biobase_2.64.0        BiocGenerics_0.50.0   cluster_2.1.6         ##  [7] rngtools_1.5.2        registry_0.5-1        RANN_2.6.2            ## [10] Matrix_1.7-0          googledrive_2.1.1     data.table_1.16.0     ## [13] Seurat_5.1.0          SeuratObject_5.0.2    sp_2.1-4              ## [16] ggplot2_3.5.1         dplyr_1.1.4           ##  ## loaded via a namespace (and not attached): ##   [1] RcppAnnoy_0.0.22            splines_4.4.1               ##   [3] later_1.3.2                 tibble_3.2.1                ##   [5] R.oo_1.26.0                 polyclip_1.10-7             ##   [7] fastDummies_1.7.4           lifecycle_1.0.4             ##   [9] doParallel_1.0.17           pals_1.9                    ##  [11] globals_0.16.3              lattice_0.22-6              ##  [13] MASS_7.3-60.2               magrittr_2.0.3              ##  [15] plotly_4.10.4               sass_0.4.9                  ##  [17] rmarkdown_2.28              jquerylib_0.1.4             ##  [19] yaml_2.3.10                 httpuv_1.6.15               ##  [21] glmGamPoi_1.16.0            sctransform_0.4.1           ##  [23] spam_2.10-0                 spatstat.sparse_3.1-0       ##  [25] reticulate_1.39.0           mapproj_1.2.11              ##  [27] cowplot_1.1.3               pbapply_1.7-2               ##  [29] RColorBrewer_1.1-3          maps_3.4.2                  ##  [31] zlibbioc_1.50.0             abind_1.4-5                 ##  [33] GenomicRanges_1.56.1        Rtsne_0.17                  ##  [35] purrr_1.0.2                 R.utils_2.12.3              ##  [37] GenomeInfoDbData_1.2.12     circlize_0.4.16             ##  [39] IRanges_2.38.1              S4Vectors_0.42.1            ##  [41] ggrepel_0.9.6               irlba_2.3.5.1               ##  [43] listenv_0.9.1               spatstat.utils_3.1-0        ##  [45] goftest_1.2-3               RSpectra_0.16-2             ##  [47] spatstat.random_3.3-1       fitdistrplus_1.2-1          ##  [49] parallelly_1.38.0           DelayedMatrixStats_1.26.0   ##  [51] pkgdown_2.1.0               DelayedArray_0.30.1         ##  [53] leiden_0.4.3.1              codetools_0.2-20            ##  [55] tidyselect_1.2.1            shape_1.4.6.1               ##  [57] farver_2.1.2                UCSC.utils_1.0.0            ##  [59] matrixStats_1.4.1           stats4_4.4.1                ##  [61] spatstat.explore_3.3-2      jsonlite_1.8.8              ##  [63] GetoptLong_1.0.5            progressr_0.14.0            ##  [65] ggridges_0.5.6              survival_3.6-4              ##  [67] iterators_1.0.14            systemfonts_1.1.0           ##  [69] foreach_1.5.2               tools_4.4.1                 ##  [71] ragg_1.3.2                  ica_1.0-3                   ##  [73] Rcpp_1.0.13                 glue_1.7.0                  ##  [75] SparseArray_1.4.8           gridExtra_2.3               ##  [77] xfun_0.47                   MatrixGenerics_1.16.0       ##  [79] GenomeInfoDb_1.40.1         withr_3.0.1                 ##  [81] BiocManager_1.30.25         fastmap_1.2.0               ##  [83] fansi_1.0.6                 digest_0.6.37               ##  [85] R6_2.5.1                    mime_0.12                   ##  [87] textshaping_0.4.0           colorspace_2.1-1            ##  [89] scattermore_1.2             tensor_1.5                  ##  [91] dichromat_2.0-0.1           spatstat.data_3.1-2         ##  [93] R.methodsS3_1.8.2           utf8_1.2.4                  ##  [95] tidyr_1.3.1                 generics_0.1.3              ##  [97] S4Arrays_1.4.1              httr_1.4.7                  ##  [99] htmlwidgets_1.6.4           uwot_0.2.2                  ## [101] pkgconfig_2.0.3             gtable_0.3.5                ## [103] ComplexHeatmap_2.20.0       lmtest_0.9-40               ## [105] XVector_0.44.0              htmltools_0.5.8.1           ## [107] dotCall64_1.1-1             clue_0.3-65                 ## [109] scales_1.3.0                png_0.1-8                   ## [111] spatstat.univar_3.0-1       knitr_1.48                  ## [113] rstudioapi_0.16.0           reshape2_1.4.4              ## [115] rjson_0.2.22                nlme_3.1-164                ## [117] curl_5.2.2                  cachem_1.1.0                ## [119] zoo_1.8-12                  GlobalOptions_0.1.2         ## [121] stringr_1.5.1               KernSmooth_2.23-24          ## [123] miniUI_0.1.1.1              desc_1.4.3                  ## [125] pillar_1.9.0                grid_4.4.1                  ## [127] vctrs_0.6.5                 promises_1.3.0              ## [129] xtable_1.8-4                evaluate_0.24.0             ## [131] cli_3.6.3                   compiler_4.4.1              ## [133] rlang_1.1.4                 crayon_1.5.3                ## [135] future.apply_1.11.2         labeling_0.4.3              ## [137] plyr_1.8.9                  fs_1.6.4                    ## [139] stringi_1.8.4               viridisLite_0.4.2           ## [141] deldir_2.0-4                gridBase_0.4-7              ## [143] munsell_0.5.1               lazyeval_0.2.2              ## [145] spatstat.geom_3.3-2         RcppHNSW_0.6.0              ## [147] patchwork_1.2.0             bit64_4.5.2                 ## [149] sparseMatrixStats_1.16.0    future_1.34.0               ## [151] shiny_1.9.1                 highr_0.11                  ## [153] SummarizedExperiment_1.34.0 ROCR_1.0-11                 ## [155] gargle_1.5.2                igraph_2.0.3                ## [157] bslib_0.8.0                 bit_4.5.0"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_scRNA.html","id":"overview","dir":"Articles","previous_headings":"","what":"Overview","title":"Recovery of Spatial Ecotypes from Single-Cell Gene Expression Data","text":"tutorial, illustrate recover spatial ecotypes (SEs) single-cell RNA-seq data. First load required packages vignette","code":"suppressPackageStartupMessages(library(dplyr)) suppressPackageStartupMessages(library(ggplot2)) suppressPackageStartupMessages(library(parallel)) suppressPackageStartupMessages(library(Seurat)) suppressPackageStartupMessages(library(data.table)) suppressPackageStartupMessages(library(googledrive)) library(SpatialEcoTyper)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_scRNA.html","id":"data-preparation","dir":"Articles","previous_headings":"","what":"Data preparation","title":"Recovery of Spatial Ecotypes from Single-Cell Gene Expression Data","text":"recovery process requires normalized gene expression matrix vector cell type annotations. seurat object demo data can accessed WU2161_seurat_obj.rds. First, load seurat object R: Next, normalize gene expression data using SCTransform NormalizeData. , normalizing using SCTransform. recommend install glmGamPoi package faster computation. , extract normalized gene expression matrix cell type annotations Seurat object. Sparse matrix .mtx format can imported using ReadMtx function Seurat package. demo data can accessed WU2161. cell type annotations available WU2161_celltype_ann.tsv. Tab-delimited files can loaded R using fread function data.table package. TSV file expression matrix can accessed WU2161_counts.tsv cell type annotations available WU2161_celltype_ann.tsv.","code":"drive_deauth() # Disable Google sign-in requirement drive_download(as_id(\"17356t3n4vY581hogyi0Gmz4Sj5v804Vz\"), \"WU2161_seurat_obj.rds\", overwrite = TRUE) # Load the seurat object obj <- readRDS(\"WU2161_seurat_obj.rds\") obj ## An object of class Seurat  ## 27425 features across 1337 samples within 1 assay  ## Active assay: RNA (27425 features, 2000 variable features) ##  3 layers present: counts, data, scale.data ##  2 dimensional reductions calculated: pca, umap # Cell type annotations unique(obj$CellType) ## [1] \"Macrophage\" \"B\"          \"CD4T\"       \"CD8T\"       \"Neuron\"     ## [6] \"Fibroblast\" \"Epithelial\" \"Plasma\" if(!\"glmGamPoi\" %in% installed.packages()){   BiocManager::install(\"glmGamPoi\") } obj <- SCTransform(obj, verbose = FALSE) seurat_version = as.integer(gsub(\"\\\\..*\", \"\", as.character(packageVersion(\"SeuratObject\")))) if(seurat_version<5){   normdata <- GetAssayData(obj, \"data\") }else{   normdata <- obj[[\"SCT\"]]$data } head(normdata[, 1:5]) ## 6 x 5 sparse Matrix of class \"dgCMatrix\" ##            AAACCTGCACATGACT-1 AAACCTGGTGGTCCGT-1 AAACCTGGTTTGTGTG-1 ## AL627309.1                  .                  .                  . ## AL627309.5                  .                  .                  . ## AP006222.2                  .                  .                  . ## LINC01409                   .                  .                  . ## LINC01128                   .                  .                  . ## LINC00115                   .                  .                  . ##            AAACCTGTCCGATATG-1 AAACCTGTCTAACGGT-1 ## AL627309.1                  .                  . ## AL627309.5                  .                  . ## AP006222.2                  .                  . ## LINC01409                   .                  . ## LINC01128                   .                  . ## LINC00115                   .                  . ctann = obj$CellType head(ctann) ## AAACCTGCACATGACT-1 AAACCTGGTGGTCCGT-1 AAACCTGGTTTGTGTG-1 AAACCTGTCCGATATG-1  ##       \"Macrophage\"                \"B\"             \"CD4T\"       \"Macrophage\"  ## AAACCTGTCTAACGGT-1 AAACGGGCACTTAAGC-1  ##                \"B\"             \"CD8T\" table(ctann) ## ctann ##          B       CD4T       CD8T Epithelial Fibroblast Macrophage     Neuron  ##         97        138        425        121         44        374         91  ##     Plasma  ##         47 ## Load the gene expression matrix scdata = ReadMtx(mtx = \"matrix.mtx\", features = \"features.tsv\",                   cells = \"barcodes.tsv\", feature.column = 1, cell.column = 1)  ## Normalize the data normdata = NormalizeData(scdata) head(normdata[, 1:5]) ## Load cell type annotation ctann = read.table(\"WU2161_celltype_ann.tsv\", sep = \"\\t\",                     header = TRUE, row.names = 1) ctann = ctann[match(colnames(normdata), rownames(ctann)), 1] table(ctann) ## Download data from google drive drive_download(as_id(\"17VAeOnz6vTt2s0ZeTrK1kITdJ3Yus4ei\"), \"WU2161_counts.tsv\", overwrite = TRUE) drive_download(as_id(\"17Ax4LMOClMBu6h_WUcwXtFw4HuIU8_AQ\"), \"WU2161_celltype_ann.tsv\", overwrite = TRUE) ## Load the gene expression matrix scdata = fread(\"WU2161_counts.tsv\", sep = \"\\t\", data.table = FALSE) rownames(scdata) = scdata[, 1] ## Set the first column as row names scdata = scdata[, -1] ## Drop the first column  ## Normalize the data normdata = NormalizeData(scdata) head(normdata[, 1:5]) ##            AAACCTGCACATGACT-1 AAACCTGGTGGTCCGT-1 AAACCTGGTTTGTGTG-1 ## AL627309.1                  0                  0                  0 ## AL627309.5                  0                  0                  0 ## AP006222.2                  0                  0                  0 ## AC114498.1                  0                  0                  0 ## AL669831.2                  0                  0                  0 ## LINC01409                   0                  0                  0 ##            AAACCTGTCCGATATG-1 AAACCTGTCTAACGGT-1 ## AL627309.1          0.0000000                  0 ## AL627309.5          0.2951209                  0 ## AP006222.2          0.0000000                  0 ## AC114498.1          0.0000000                  0 ## AL669831.2          0.0000000                  0 ## LINC01409           0.0000000                  0 ## Load cell type annotation ctann = read.table(\"WU2161_celltype_ann.tsv\", sep = \"\\t\",                     header = TRUE, row.names = 1) ctann = ctann[match(colnames(normdata), rownames(ctann)), 1] table(ctann) ## ctann ##          B       CD4T       CD8T Epithelial Fibroblast Macrophage     Plasma  ##         97        138        425        121         44        374         47  ##    Unknown  ##         91"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_scRNA.html","id":"se-recovery","dir":"Articles","previous_headings":"","what":"SE recovery","title":"Recovery of Spatial Ecotypes from Single-Cell Gene Expression Data","text":"RecoverSE function used assign single cells SEs. Users can either use default model recover predefined SEs use custom model recover newly defined SEs. Note: using RecoverSE single-cell RNA-seq data, essential specify celltypes parameter. cell type annotations provided, function assume input data corresponds bulk spatial transcriptomics (e.g., Visium), infer SE abundances spot. default NMF models trained discovery MERSCOPE data, encompassing five cancer types: melanoma, four carcinomas. models tailored nine distinct cell types: B cells, CD4+ T cells, CD8+ T cells, NK cells, plasma cells, macrophages, dendritic cells, fibroblasts, endothelial cells. model facilitates recovery SEs single-cell datasets, allowing cell-type-specific SE analysis. SE recovery, cells query data grouped one “B”, “CD4T”, “CD8T”, “NK”, “Plasma”, “Macrophage”, “DC”, “Fibroblast”, “Endothelial”, case sensitive. cell types considered non-SE compartments. use custom models, users first develop recovery models following tutorial Development SE Recovery Models. resulting models can used SE recovery. example model available SE_Recovery_W_list.rds. Download example models Load custom models Using custom models SE recovery specifying Ws argument.","code":"sepreds <- RecoverSE(normdata, celltypes = ctann) head(sepreds) ## AAACCTGCACATGACT-1 AAACCTGGTGGTCCGT-1 AAACCTGGTTTGTGTG-1 AAACCTGTCCGATATG-1  ##              \"SE8\"            \"nonSE\"              \"SE1\"              \"SE8\"  ## AAACCTGTCTAACGGT-1 AAACGGGCACTTAAGC-1  ##            \"nonSE\"            \"nonSE\" drive_download(as_id(\"171WaAe49babYB85Cn1FcoNNE-lzYp1T_\"), \"SE_Recovery_W_list.rds\", overwrite = TRUE) Ws <- readRDS(\"SE_Recovery_W_list.rds\") names(Ws) ## named list of W matrices ## [1] \"CD4T\"        \"CD8T\"        \"DC\"          \"Endothelial\" \"Fibroblast\"  ## [6] \"Macrophage\"  \"NK\"          \"Plasma\" head(Ws[[1]]) ## feature by SE matrix ##                  SE01      SE02      SE03      SE04      SE05      SE06 ## CD226__pos  0.4145936 0.2555579 0.3323735 0.3241147 0.2263783 0.3279133 ## CDKN1B__pos 0.5729663 0.4552065 0.5120732 0.4627805 0.4453117 0.5156023 ## CXCR4__pos  0.5865790 0.2771225 0.4093821 0.3607076 0.3589891 0.3937211 ## DUSP1__pos  0.4233067 0.3462390 0.2269798 0.1616814 0.3265539 0.2562118 ## KLF2__pos   0.5889618 0.2314586 0.3867504 0.2295206 0.2998234 0.5173246 ## ICAM2__pos  0.4593230 0.2611751 0.4427930 0.3143084 0.3679498 0.4532637 ##                  SE07      SE08      SE09      SE10      SE11 ## CD226__pos  0.2189382 0.3417897 0.2563481 0.2360192 0.2815938 ## CDKN1B__pos 0.4414750 0.4747166 0.4414508 0.3922732 0.3821411 ## CXCR4__pos  0.3751669 0.4456410 0.3023204 0.2629156 0.2729461 ## DUSP1__pos  0.3682236 0.2211759 0.1713413 0.1699067 0.1121763 ## KLF2__pos   0.3570251 0.4327206 0.1732251 0.2086729 0.2118797 ## ICAM2__pos  0.2660441 0.5494585 0.2878338 0.3711269 0.2575091 sepreds <- RecoverSE(normdata, celltypes = ctann, Ws = Ws) head(sepreds) ## AAACCTGCACATGACT-1 AAACCTGGTGGTCCGT-1 AAACCTGGTTTGTGTG-1 AAACCTGTCCGATATG-1  ##             \"SE10\"            \"nonSE\"             \"SE01\"             \"SE10\"  ## AAACCTGTCTAACGGT-1 AAACGGGCACTTAAGC-1  ##            \"nonSE\"             \"SE03\""},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_scRNA.html","id":"session-info","dir":"Articles","previous_headings":"","what":"Session info","title":"Recovery of Spatial Ecotypes from Single-Cell Gene Expression Data","text":"session info allows users replicate exact environment identify potential discrepancies package versions configurations might causing problems.","code":"sessionInfo() ## R version 4.4.1 (2024-06-14) ## Platform: aarch64-apple-darwin20 ## Running under: macOS 15.1 ##  ## Matrix products: default ## BLAS:   /Library/Frameworks/R.framework/Versions/4.4-arm64/Resources/lib/libRblas.0.dylib  ## LAPACK: /Library/Frameworks/R.framework/Versions/4.4-arm64/Resources/lib/libRlapack.dylib;  LAPACK version 3.12.0 ##  ## locale: ## [1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8 ##  ## time zone: America/Los_Angeles ## tzcode source: internal ##  ## attached base packages: ## [1] parallel  stats     graphics  grDevices utils     datasets  methods   ## [8] base      ##  ## other attached packages: ##  [1] SpatialEcoTyper_1.0.0 NMF_0.28              Biobase_2.64.0        ##  [4] BiocGenerics_0.50.0   cluster_2.1.6         rngtools_1.5.2        ##  [7] registry_0.5-1        RANN_2.6.2            Matrix_1.7-0          ## [10] googledrive_2.1.1     data.table_1.16.0     Seurat_5.1.0          ## [13] SeuratObject_5.0.2    sp_2.1-4              ggplot2_3.5.1         ## [16] dplyr_1.1.4           ##  ## loaded via a namespace (and not attached): ##   [1] RcppAnnoy_0.0.22            splines_4.4.1               ##   [3] later_1.3.2                 tibble_3.2.1                ##   [5] polyclip_1.10-7             fastDummies_1.7.4           ##   [7] lifecycle_1.0.4             doParallel_1.0.17           ##   [9] globals_0.16.3              lattice_0.22-6              ##  [11] MASS_7.3-60.2               magrittr_2.0.3              ##  [13] plotly_4.10.4               sass_0.4.9                  ##  [15] rmarkdown_2.28              jquerylib_0.1.4             ##  [17] yaml_2.3.10                 httpuv_1.6.15               ##  [19] glmGamPoi_1.16.0            sctransform_0.4.1           ##  [21] spam_2.10-0                 spatstat.sparse_3.1-0       ##  [23] reticulate_1.39.0           cowplot_1.1.3               ##  [25] pbapply_1.7-2               RColorBrewer_1.1-3          ##  [27] zlibbioc_1.50.0             abind_1.4-5                 ##  [29] GenomicRanges_1.56.1        Rtsne_0.17                  ##  [31] purrr_1.0.2                 circlize_0.4.16             ##  [33] GenomeInfoDbData_1.2.12     IRanges_2.38.1              ##  [35] S4Vectors_0.42.1            ggrepel_0.9.6               ##  [37] irlba_2.3.5.1               listenv_0.9.1               ##  [39] spatstat.utils_3.1-0        goftest_1.2-3               ##  [41] RSpectra_0.16-2             spatstat.random_3.3-1       ##  [43] fitdistrplus_1.2-1          parallelly_1.38.0           ##  [45] DelayedMatrixStats_1.26.0   pkgdown_2.1.0               ##  [47] DelayedArray_0.30.1         leiden_0.4.3.1              ##  [49] codetools_0.2-20            tidyselect_1.2.1            ##  [51] shape_1.4.6.1               UCSC.utils_1.0.0            ##  [53] matrixStats_1.4.1           stats4_4.4.1                ##  [55] spatstat.explore_3.3-2      jsonlite_1.8.8              ##  [57] GetoptLong_1.0.5            progressr_0.14.0            ##  [59] ggridges_0.5.6              survival_3.6-4              ##  [61] iterators_1.0.14            systemfonts_1.1.0           ##  [63] foreach_1.5.2               tools_4.4.1                 ##  [65] ragg_1.3.2                  ica_1.0-3                   ##  [67] Rcpp_1.0.13                 glue_1.7.0                  ##  [69] SparseArray_1.4.8           gridExtra_2.3               ##  [71] xfun_0.47                   MatrixGenerics_1.16.0       ##  [73] GenomeInfoDb_1.40.1         withr_3.0.1                 ##  [75] BiocManager_1.30.25         fastmap_1.2.0               ##  [77] fansi_1.0.6                 digest_0.6.37               ##  [79] R6_2.5.1                    mime_0.12                   ##  [81] textshaping_0.4.0           colorspace_2.1-1            ##  [83] scattermore_1.2             tensor_1.5                  ##  [85] spatstat.data_3.1-2         utf8_1.2.4                  ##  [87] tidyr_1.3.1                 generics_0.1.3              ##  [89] S4Arrays_1.4.1              httr_1.4.7                  ##  [91] htmlwidgets_1.6.4           uwot_0.2.2                  ##  [93] pkgconfig_2.0.3             gtable_0.3.5                ##  [95] ComplexHeatmap_2.20.0       lmtest_0.9-40               ##  [97] XVector_0.44.0              htmltools_0.5.8.1           ##  [99] dotCall64_1.1-1             clue_0.3-65                 ## [101] scales_1.3.0                png_0.1-8                   ## [103] spatstat.univar_3.0-1       knitr_1.48                  ## [105] rstudioapi_0.16.0           reshape2_1.4.4              ## [107] rjson_0.2.22                nlme_3.1-164                ## [109] curl_5.2.2                  cachem_1.1.0                ## [111] zoo_1.8-12                  GlobalOptions_0.1.2         ## [113] stringr_1.5.1               KernSmooth_2.23-24          ## [115] miniUI_0.1.1.1              desc_1.4.3                  ## [117] pillar_1.9.0                grid_4.4.1                  ## [119] vctrs_0.6.5                 promises_1.3.0              ## [121] xtable_1.8-4                evaluate_0.24.0             ## [123] cli_3.6.3                   compiler_4.4.1              ## [125] rlang_1.1.4                 crayon_1.5.3                ## [127] future.apply_1.11.2         plyr_1.8.9                  ## [129] fs_1.6.4                    stringi_1.8.4               ## [131] viridisLite_0.4.2           deldir_2.0-4                ## [133] gridBase_0.4-7              munsell_0.5.1               ## [135] lazyeval_0.2.2              spatstat.geom_3.3-2         ## [137] RcppHNSW_0.6.0              patchwork_1.2.0             ## [139] sparseMatrixStats_1.16.0    future_1.34.0               ## [141] shiny_1.9.1                 SummarizedExperiment_1.34.0 ## [143] ROCR_1.0-11                 gargle_1.5.2                ## [145] igraph_2.0.3                bslib_0.8.0"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/SingleSample.html","id":"overview","dir":"Articles","previous_headings":"","what":"Overview","title":"Discovery of Spatial Ecotypes from a Single Sample","text":"tutorial, illustrate perform de novo discovery spatially distinct cellular ecosystems (SEs) single-cell spatial transcriptomics dataset using SpatialEcoTyper. analyzing single-cell spatial transcriptomics data melanoma sample (raw data available Vizgen’s MERSCOPE FFPE Human Immuno-oncology). quickly demonstrate SpatialEcoTyper works, ’ve selected subset sample, can downloaded . demo data comprises spatial expression 500 genes across 27,907 cells, categorized ten distinct cell types: B cells, CD4+ T cells, CD8+ T cells, NK cells, plasma cells, macrophages, dendritic cells (DC), fibroblasts, endothelial cells, cancer cell origin (CCOs). Given large proportion CCOs, order reduce running time, CCOs excluded demonstration. Besides, cells grouped four regions, including tumor, inner margin, outer margin, stroma. tumor stroma regions defined based density CCOs. detailed information tumor stroma annotations, please refer CytoSPACE paper. inner outer margins delineated regions extending 250 μm inside outside tumor boundaries, respectively. addition, assessed distance single cell tumor/stroma interface computing shortest Euclidean distance tumor regions (stromal regions) cells localized stromal region (tumor regions). positive distance used cells localized tumor region, negative distance used cells localized stroma region. SpatialEcoTyper analysis requires two input data: gene expression matrix: rows represent gene names columns represent cell IDs meta data: data frame least three columns, including “X” (X-coordinate), “Y” (Y-coordinate), “CellType” (cell type annotation). row names meta data match column names (cell IDs) expression matrix. First load required packages vignette","code":"suppressPackageStartupMessages(library(dplyr)) suppressPackageStartupMessages(library(ggplot2)) suppressPackageStartupMessages(library(parallel)) suppressPackageStartupMessages(library(Seurat)) suppressPackageStartupMessages(library(data.table)) suppressPackageStartupMessages(library(googledrive)) suppressPackageStartupMessages(library(R.utils))  library(SpatialEcoTyper)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/SingleSample.html","id":"loading-data","dir":"Articles","previous_headings":"","what":"Loading data","title":"Discovery of Spatial Ecotypes from a Single Sample","text":"Download data Google Drive Large text files can loaded R using fread function data.table package. SpatialEcoTyper supports sparse matrix input. Mtx files can loaded R using ReadMtx function Seurat package.","code":"drive_deauth() # Disable Google sign-in requirement drive_download(as_id(\"13Rc5Rsu8jbnEYYfUse-xQ7ges51LcI7n\"), \"HumanMelanomaPatient1_subset_counts.tsv.gz\", overwrite = TRUE) drive_download(as_id(\"12xcZNhpT-xbhcG8kX1QAdTeM9TKeFAUW\"), \"HumanMelanomaPatient1_subset_scmeta.tsv\", overwrite = TRUE) # Load single-cell gene expression matrix. Rows represent gene names and columns represent cell IDs scdata <- fread(\"HumanMelanomaPatient1_subset_counts.tsv.gz\",                  sep = \"\\t\",header = TRUE, data.table = FALSE) rownames(scdata) <- scdata[, 1]  # Setting the first column as row names scdata <- as.matrix(scdata[, -1]) # Dropping first column head(scdata[, 1:5]) ##          HumanMelanomaPatient1__cell_3655 HumanMelanomaPatient1__cell_3657 ## PDK4                                    0                                1 ## TNFRSF17                                0                                0 ## ICAM3                                   0                                0 ## FAP                                     1                                0 ## GZMB                                    0                                0 ## TSC2                                    0                                0 ##          HumanMelanomaPatient1__cell_3658 HumanMelanomaPatient1__cell_3660 ## PDK4                                    1                                0 ## TNFRSF17                                0                                0 ## ICAM3                                   0                                0 ## FAP                                     0                                0 ## GZMB                                    0                                0 ## TSC2                                    0                                0 ##          HumanMelanomaPatient1__cell_3661 ## PDK4                                    0 ## TNFRSF17                                0 ## ICAM3                                   0 ## FAP                                     0 ## GZMB                                    0 ## TSC2                                    0 # Load single-cell metadata # Three columns are required, including \"X\", \"Y\", and \"CellType\" # The row names should match the cell ids in the expression matrix scmeta <- read.table(\"HumanMelanomaPatient1_subset_scmeta.tsv\",                        sep = \"\\t\",header = TRUE, row.names = 1) scmeta <- scmeta[match(colnames(scdata), rownames(scmeta)), ] # match the cell ids in scdata and scmeta head(scmeta[, c(\"X\", \"Y\", \"CellType\")]) ##                                         X         Y   CellType ## HumanMelanomaPatient1__cell_3655 1894.706 -6367.766 Fibroblast ## HumanMelanomaPatient1__cell_3657 1942.480 -6369.602 Fibroblast ## HumanMelanomaPatient1__cell_3658 1963.007 -6374.026 Fibroblast ## HumanMelanomaPatient1__cell_3660 1981.600 -6372.266 Fibroblast ## HumanMelanomaPatient1__cell_3661 1742.939 -6374.851 Fibroblast ## HumanMelanomaPatient1__cell_3663 1921.683 -6383.309 Fibroblast drive_download(as_id(\"13M3xhRxp0xK9gf5F4DE9idSBFqVQIXDT\"), \"HumanMelanomaPatient1_subset_counts.mtx.gz\", overwrite = TRUE) drive_download(as_id(\"136feRaFjMtNvduLTm5xqa3WhyyoG4Xzo\"), \"HumanMelanomaPatient1_subset_cells.tsv.gz\", overwrite = TRUE) drive_download(as_id(\"13QprWzJhzzUy_w3XSrjlt9pjf2n-G7HV\"), \"HumanMelanomaPatient1_subset_genes.tsv.gz\", overwrite = TRUE)  scdata <- ReadMtx(mtx = \"HumanMelanomaPatient1_subset_counts.mtx.gz\",                    cells = \"HumanMelanomaPatient1_subset_cells.tsv.gz\",                    features = \"HumanMelanomaPatient1_subset_genes.tsv.gz\",                   feature.column = 1, cell.column = 1)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/SingleSample.html","id":"data-normalization","dir":"Articles","previous_headings":"","what":"Data normalization","title":"Discovery of Spatial Ecotypes from a Single Sample","text":"gene expression data normalized SpatialEcoTyper analysis. data can normalized using NormalizeData SCTransform. , normalizing using SCTransform normalization. recommend install glmGamPoi package faster computation.","code":"if(!\"glmGamPoi\" %in% installed.packages()){   BiocManager::install(\"glmGamPoi\") } tmpobj <- CreateSeuratObject(scdata) %>%       SCTransform(clip.range = c(-10, 10), verbose = FALSE)  seurat_version = as.integer(gsub(\"\\\\..*\", \"\", as.character(packageVersion(\"SeuratObject\")))) if(seurat_version<5){   normdata <- GetAssayData(tmpobj, \"data\") }else{   normdata <- tmpobj[[\"SCT\"]]$data } normdata <- NormalizeData(scdata)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/SingleSample.html","id":"preview-of-the-sample","dir":"Articles","previous_headings":"","what":"Preview of the sample","title":"Discovery of Spatial Ecotypes from a Single Sample","text":"SpatialView function can used visualize single cells spatial space, cell type region.   SpatialView function can also used visualize continuous characteristics, minimum distance single cell tumor/stroma margin. , positive distances indicate cells located within tumor region, negative distances denote cells within stroma.","code":"# Visualize the cell type annotations in the tissue SpatialView(scmeta, by = \"CellType\") + scale_color_manual(values = pals::cols25()) # Visualize the regions in the tissue SpatialView(scmeta, by = \"Region\") + scale_color_brewer(type = \"qual\", palette = \"Set1\") # Visualize the distance to tumor margin SpatialView(scmeta, by = \"Dist2Interface\") +    scale_colour_gradient2(low = \"#5e3c99\", high = \"#e66101\",                           mid = \"#d9d9d9\", midpoint = 0) +    labs(color = \"Distance to\\ntumor margin\")"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/SingleSample.html","id":"se-discovery-using-spatialecotyper","dir":"Articles","previous_headings":"","what":"SE discovery using SpatialEcoTyper","title":"Discovery of Spatial Ecotypes from a Single Sample","text":"SpatialEcoTyper function designed identify spatial ecotypes (SEs) single-cell spatial transcriptomics data. workflow begins grouping spatially co-localized single cells microregions, cell-type-specific gene expression profiles (GEPs) constructed microregion. Following , similarity networks microregions constructed based cell type-specific GEPs. integrate networks, SpatialEcoTyper utilizes Similarity Network Fusion (SNF) method, originally developed multi-omics data integration (Wang et al., 2014). fused similarity network enables identification SEs clustering. normdata matrix representing normalized gene expression data, rows correspond genes columns correspond cells. metadata data frame containing metadata associated cell. Must include spatial coordinates (e.g., X Y) well cell type annotations. row names must match column names normdata. outprefix Character string specifying prefix output file names. radius Numeric specifying radius (default: 50 µm) defining spatial microregion. minibatch Integer specifying number columns process minibatch SNF analysis. Default 5000. option splits matrix smaller chunks (minibatch), thus reducing memory usage. ncores Integer specifying number CPU cores use parallel processing. can type ?SpatialEcoTyper visualize full manual. real-world single-cell ST datasets 100,000 cells, analysis can time- memory-intensive. speed process, can increase number cores used (ncores), also increase memory consumption. limited computational memory, several strategies reduce usage. One approach decrease minibatch size reduce number cores (ncores) allocated. However, larger datasets, minimum memory requirement may remain high. Another option increase grid.size, reduces number spatial microregions. can significantly decrease memory usage downsampling ST data, potentially excluding many cells analysis though. ’re interested studying multicellular communities associated specific cell types, can use filter.region..celltypes argument focus microregions containing least one cell specified cell types. example, identify multicellular communities related T cells, can use following command. ’re interested regions composed multiple cell types, can use min.cts.per.region argument specify minimum number distinct cell types required microregion included analysis.","code":"## This step takes ~2 minutes to complete on macOS with an Apple M1 Pro chip and 16 GB memory. se_results <- SpatialEcoTyper(normdata, scmeta,                               outprefix = \"Melanoma1_subset\",                               radius = 50, ncores = 2) se_results <- SpatialEcoTyper(normdata, scmeta,                               outprefix = \"Melanoma1_subset\",                               radius = 50, ncores = 2,                               filter.region.by.celltypes = c(\"CD8T\", \"CD4T\")) se_results <- SpatialEcoTyper(normdata, scmeta,                               outprefix = \"Melanoma1_subset\",                               radius = 50, ncores = 2,                               min.cts.per.region = 2)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/SingleSample.html","id":"spatialecotyper-result","dir":"Articles","previous_headings":"","what":"SpatialEcoTyper result","title":"Discovery of Spatial Ecotypes from a Single Sample","text":"outprefix specified, SpatialEcoTyper result saved RDS file named outprefix_SpatialEcoTyper_results.rds. result can loaded R using readRDS. SpatialEcoTyper result list includes two key components: Seurat object constructed integrated embedding spatial microregions, allowing detailed analysis visualization spatial architecture; data frame single-cell metadata, includes annotations discovered spatial ecotypes. annotations can used explore spatial distribution characteristics SEs within tissue.","code":"## drive_download(as_id(\"18AzHCtwwXoOM9_yRCjyfzcLQaWiQo1au\"), \"Melanoma1_subset_SpatialEcoTyper_results.rds\", overwrite = TRUE) se_results <- readRDS(\"Melanoma1_subset_SpatialEcoTyper_results.rds\") # Extract the Seurat object and updated single-cell metadata obj <- se_results$obj # A Seurat object scmeta <- se_results$metadata # Updated single-cell meta data, with SE annotation added head(scmeta) ##                                         X         Y   CellType CellTypeName ## HumanMelanomaPatient1__cell_3655 1894.706 -6367.766 Fibroblast  Fibroblasts ## HumanMelanomaPatient1__cell_3657 1942.480 -6369.602 Fibroblast  Fibroblasts ## HumanMelanomaPatient1__cell_3658 1963.007 -6374.026 Fibroblast  Fibroblasts ## HumanMelanomaPatient1__cell_3660 1981.600 -6372.266 Fibroblast  Fibroblasts ## HumanMelanomaPatient1__cell_3661 1742.939 -6374.851 Fibroblast  Fibroblasts ## HumanMelanomaPatient1__cell_3663 1921.683 -6383.309 Fibroblast  Fibroblasts ##                                  Region Dist2Interface  SE ## HumanMelanomaPatient1__cell_3655 Stroma      -883.1752 SE6 ## HumanMelanomaPatient1__cell_3657 Stroma      -894.8463 SE7 ## HumanMelanomaPatient1__cell_3658 Stroma      -904.1115 SE7 ## HumanMelanomaPatient1__cell_3660 Stroma      -907.8909 SE7 ## HumanMelanomaPatient1__cell_3661 Stroma      -874.2712 SE0 ## HumanMelanomaPatient1__cell_3663 Stroma      -903.6559 SE6 table(scmeta$SE) ## The number of cells in each SE ##  ##  SE0  SE1  SE2  SE3  SE4  SE5  SE6  SE7  ## 2847 6724 2773 5324 1857 3285 2856 2124"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/SingleSample.html","id":"embedding-of-spatial-architecture","dir":"Articles","previous_headings":"","what":"Embedding of spatial architecture","title":"Discovery of Spatial Ecotypes from a Single Sample","text":"spatial microregions’ embedding can visualized using standard Seurat functions DimPlot FeaturePlot. visualizations help explore spatial organization heterogeneity within tissue. Note: embedding clustering results differ slightly Seurat v4 v5. However, overall clustering patterns remain largely consistent, Adjusted Rand Index (ARI) 0.7 demonstration dataset. consistency ensures , despite minor variations, key biological insights preserved across versions.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/SingleSample.html","id":"visualizing-tumorstroma-regions-in-the-embedding","dir":"Articles","previous_headings":"Embedding of spatial architecture","what":"Visualizing tumor/stroma regions in the embedding","title":"Discovery of Spatial Ecotypes from a Single Sample","text":"","code":"DimPlot(obj, group.by = \"Region\") + scale_color_brewer(type = \"qual\", palette = \"Set1\")"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/SingleSample.html","id":"visualizing-the-distance-of-microregions-to-tumorstroma-interface","dir":"Articles","previous_headings":"Embedding of spatial architecture","what":"Visualizing the distance of microregions to tumor/stroma interface","title":"Discovery of Spatial Ecotypes from a Single Sample","text":"plot highlights distance spatial microregion tumor/stroma interface, revealing spatial continuum learnt SpatialEcoTyper. , positive distances indicate microregions located within tumor region, negative distances denote microregions within stroma.","code":"FeaturePlot(obj, \"Dist2Interface\", min.cutoff = -600, max.cutoff = 600) +    scale_colour_gradient2(low = \"#5e3c99\", high = \"#e66101\", mid = \"#d9d9d9\", midpoint = 0)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/SingleSample.html","id":"visualizing-spatial-ecotypes-in-the-embedding","dir":"Articles","previous_headings":"Embedding of spatial architecture","what":"Visualizing spatial ecotypes in the embedding","title":"Discovery of Spatial Ecotypes from a Single Sample","text":"plot visualizes SEs within spatial embedding. SEs represent distinct spatial microenvironments, unique cellular compositions spatial characteristics.","code":"DimPlot(obj, group.by = \"SE\") + scale_color_manual(values = pals::kelly()[-1])"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/SingleSample.html","id":"visualizing-the-most-abundant-cell-types-in-each-spatial-microregion","dir":"Articles","previous_headings":"Embedding of spatial architecture","what":"Visualizing the most abundant cell types in each spatial microregion","title":"Discovery of Spatial Ecotypes from a Single Sample","text":", focus visualizing dominant cell types within spatial microregion highlight characteristic cellular composition different SEs.","code":"DimPlot(obj, group.by = \"CellType\") +   scale_color_manual(values = pals::cols25())"},{"path":[]},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/SingleSample.html","id":"visualizing-ses-in-the-tissue","dir":"Articles","previous_headings":"SE characteristics","what":"Visualizing SEs in the tissue","title":"Discovery of Spatial Ecotypes from a Single Sample","text":"spatial distribution SEs within tissue can visualized using SpatialView function. visualization provides insights localization spatial organization different SEs across tissue section.  Note: NA values SE annotations denote cells excluded analysis, due absence neighboring cells insufficient number detected genes.","code":"SpatialView(scmeta, by = \"SE\")"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/SingleSample.html","id":"visualizing-the-cell-type-composition-of-ses","dir":"Articles","previous_headings":"SE characteristics","what":"Visualizing the cell type composition of SEs","title":"Discovery of Spatial Ecotypes from a Single Sample","text":"bar plot illustrates cell type composition within SE. visualization helps identify dominant cell types SE compare cellular makeup across different SEs.","code":"gg <- scmeta %>% filter(!is.na(SE)) %>% count(SE, CellType) ggplot(gg, aes(SE, n, fill = CellType)) +    geom_bar(stat = \"identity\", position = \"fill\") +   scale_fill_manual(values = pals::cols25()) +   theme_bw(base_size = 14) + coord_flip() +    labs(y = \"Cell type abundance\")"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/SingleSample.html","id":"visualizing-the-association-between-ses-and-pre-annotated-regions","dir":"Articles","previous_headings":"SE characteristics","what":"Visualizing the association between SEs and pre-annotated regions","title":"Discovery of Spatial Ecotypes from a Single Sample","text":"bar plot shows relationship SEs pre-annotated regions, tumor stroma. proportion SE associated regions displayed, providing insights SEs correspond different tissue regions.","code":"gg <- scmeta %>% filter(!is.na(SE)) %>% count(SE, Region) ggplot(gg, aes(SE, n, fill = Region)) +    geom_bar(stat = \"identity\", position = \"fill\") +    scale_fill_brewer(type = \"qual\", palette = \"Set1\") +   theme_bw(base_size = 14) + coord_flip() +    labs(y = \"Fraction\")"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/SingleSample.html","id":"visualizing-the-distance-of-ses-to-tumorstroma-interface","dir":"Articles","previous_headings":"SE characteristics","what":"Visualizing the distance of SEs to tumor/stroma interface","title":"Discovery of Spatial Ecotypes from a Single Sample","text":"box plot visualizes distribution distances SEs tumor/stroma interface. Positive distances indicate cells located within tumor region, negative distances denote cells within stroma. SEs ordered median distance, highlighting spatial localization relative tumor/stroma interface.","code":"gg <- scmeta %>% filter(!is.na(SE)) ## Order SEs by their distance to tumor/stroma interface tmp <-  gg %>% group_by(SE) %>% summarise(Mid = median(Dist2Interface)) %>% arrange(Mid) %>% pull(SE) gg$SE = factor(gg$SE, levels = tmp) ggplot(gg, aes(SE, Dist2Interface)) +    geom_boxplot() + theme_bw() + labs(y = \"Distance to tumor/stroma interface (μm)\")"},{"path":[]},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/SingleSample.html","id":"differential-expression-analysis","dir":"Articles","previous_headings":"Identification of cell-type-specific SE markers","what":"Differential expression analysis","title":"Discovery of Spatial Ecotypes from a Single Sample","text":"identify cell-type-specific SE markers, can perform differential expression analysis using presto package. example identify fibroblast-specific markers SE. Note: MERSCOPE data used SE discovery includes limited number genes. enhance analysis, can extend differential expression analysis whole transcriptome aligning scRNA-seq data spatial transcriptomics data via CytoSPACE.","code":"if(!\"presto\" %in% installed.packages()){    BiocManager::install(\"devtools\")   devtools::install_github(\"immunogenomics/presto\") } library(\"presto\")  # Ensure the normalized data is aligned with the single-cell metadata normdata = normdata[, rownames(scmeta)]  # Perform differential expression analysis for fibroblasts across SEs idx = which(scmeta$CellType==\"Fibroblast\" & !is.na(scmeta$SE)) degs = wilcoxauc(normdata[, idx], scmeta$SE[idx])  # Filter for significant markers with positive log-fold change degs = degs %>% filter(logFC>0 & pval<0.05) %>% arrange(desc(logFC)) head(degs) ##   feature group  avgExpr     logFC statistic       auc          pval ## 1   ACTA2   SE7 2.269714 1.9200869   4826706 0.7719666 6.157041e-196 ## 2 PLA2G2A   SE0 2.076013 1.4444331   9636530 0.8226676  0.000000e+00 ## 3 PLA2G2A   SE6 2.177647 1.4145934   5418244 0.7996960 2.595786e-219 ## 4     PKM   SE4 2.592488 1.3997410   3527900 0.8820820 1.875924e-178 ## 5     FN1   SE3 3.124745 1.1463924   5771112 0.7979963 4.778744e-193 ## 6 HLA-DRA   SE3 1.711258 0.9756877   5434388 0.7514360 8.958194e-160 ##            padj   pct_in  pct_out ## 1 8.455670e-194 69.35897 30.37675 ## 2  0.000000e+00 90.22005 34.38547 ## 3 1.069464e-216 88.39390 40.08561 ## 4 3.864404e-176 98.75260 81.20265 ## 5 4.922107e-191 98.03922 88.25844 ## 6 6.151293e-158 86.05664 43.91978"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/SingleSample.html","id":"visualizing-the-expression-of-cell-state-markers","dir":"Articles","previous_headings":"Identification of cell-type-specific SE markers","what":"Visualizing the expression of cell state markers","title":"Discovery of Spatial Ecotypes from a Single Sample","text":"’ve identified potential markers, can visualize expression across SEs. example using ACTA2 gene.  can also visualize expression marker (e.g., ACTA2) tissue.","code":"## Gene expression across all SEs gg <- scmeta[idx, ] gg$Expression <- normdata[\"ACTA2\", idx] ggplot(gg, aes(SE, Expression)) + geom_boxplot() +    theme_classic(base_size = 14) + ylab(\"ACTA2 expression\") ## Visualize gene expression in spatial gg <- scmeta gg$Expression <- normdata[\"ACTA2\", ] SpatialView(gg, by = \"Expression\") + scale_color_viridis_c() +    labs(color = \"ACTA2\\nexpression\")"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/SingleSample.html","id":"session-info","dir":"Articles","previous_headings":"","what":"Session info","title":"Discovery of Spatial Ecotypes from a Single Sample","text":"session info allows users replicate exact environment identify potential discrepancies package versions configurations might causing problems.","code":"sessionInfo() ## R version 4.4.1 (2024-06-14) ## Platform: aarch64-apple-darwin20 ## Running under: macOS 15.1 ##  ## Matrix products: default ## BLAS:   /Library/Frameworks/R.framework/Versions/4.4-arm64/Resources/lib/libRblas.0.dylib  ## LAPACK: /Library/Frameworks/R.framework/Versions/4.4-arm64/Resources/lib/libRlapack.dylib;  LAPACK version 3.12.0 ##  ## locale: ## [1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8 ##  ## time zone: America/Los_Angeles ## tzcode source: internal ##  ## attached base packages: ## [1] parallel  stats     graphics  grDevices utils     datasets  methods   ## [8] base      ##  ## other attached packages: ##  [1] presto_1.0.0          Rcpp_1.0.13           SpatialEcoTyper_1.0.0 ##  [4] NMF_0.28              Biobase_2.64.0        BiocGenerics_0.50.0   ##  [7] cluster_2.1.6         rngtools_1.5.2        registry_0.5-1        ## [10] RANN_2.6.2            Matrix_1.7-0          R.utils_2.12.3        ## [13] R.oo_1.26.0           R.methodsS3_1.8.2     googledrive_2.1.1     ## [16] data.table_1.16.0     Seurat_5.1.0          SeuratObject_5.0.2    ## [19] sp_2.1-4              ggplot2_3.5.1         dplyr_1.1.4           ##  ## loaded via a namespace (and not attached): ##   [1] RcppAnnoy_0.0.22            splines_4.4.1               ##   [3] later_1.3.2                 tibble_3.2.1                ##   [5] polyclip_1.10-7             fastDummies_1.7.4           ##   [7] lifecycle_1.0.4             doParallel_1.0.17           ##   [9] pals_1.9                    globals_0.16.3              ##  [11] lattice_0.22-6              MASS_7.3-60.2               ##  [13] magrittr_2.0.3              plotly_4.10.4               ##  [15] sass_0.4.9                  rmarkdown_2.28              ##  [17] jquerylib_0.1.4             yaml_2.3.10                 ##  [19] httpuv_1.6.15               glmGamPoi_1.16.0            ##  [21] sctransform_0.4.1           spam_2.10-0                 ##  [23] spatstat.sparse_3.1-0       reticulate_1.39.0           ##  [25] mapproj_1.2.11              cowplot_1.1.3               ##  [27] pbapply_1.7-2               RColorBrewer_1.1-3          ##  [29] maps_3.4.2                  zlibbioc_1.50.0             ##  [31] abind_1.4-5                 GenomicRanges_1.56.1        ##  [33] Rtsne_0.17                  purrr_1.0.2                 ##  [35] GenomeInfoDbData_1.2.12     circlize_0.4.16             ##  [37] IRanges_2.38.1              S4Vectors_0.42.1            ##  [39] ggrepel_0.9.6               irlba_2.3.5.1               ##  [41] listenv_0.9.1               spatstat.utils_3.1-0        ##  [43] goftest_1.2-3               RSpectra_0.16-2             ##  [45] spatstat.random_3.3-1       fitdistrplus_1.2-1          ##  [47] parallelly_1.38.0           DelayedMatrixStats_1.26.0   ##  [49] pkgdown_2.1.0               DelayedArray_0.30.1         ##  [51] leiden_0.4.3.1              codetools_0.2-20            ##  [53] tidyselect_1.2.1            shape_1.4.6.1               ##  [55] farver_2.1.2                UCSC.utils_1.0.0            ##  [57] matrixStats_1.4.1           stats4_4.4.1                ##  [59] spatstat.explore_3.3-2      jsonlite_1.8.8              ##  [61] GetoptLong_1.0.5            progressr_0.14.0            ##  [63] ggridges_0.5.6              survival_3.6-4              ##  [65] iterators_1.0.14            systemfonts_1.1.0           ##  [67] foreach_1.5.2               tools_4.4.1                 ##  [69] ragg_1.3.2                  ica_1.0-3                   ##  [71] glue_1.7.0                  SparseArray_1.4.8           ##  [73] gridExtra_2.3               xfun_0.47                   ##  [75] MatrixGenerics_1.16.0       GenomeInfoDb_1.40.1         ##  [77] withr_3.0.1                 BiocManager_1.30.25         ##  [79] fastmap_1.2.0               fansi_1.0.6                 ##  [81] digest_0.6.37               R6_2.5.1                    ##  [83] mime_0.12                   textshaping_0.4.0           ##  [85] colorspace_2.1-1            scattermore_1.2             ##  [87] tensor_1.5                  dichromat_2.0-0.1           ##  [89] spatstat.data_3.1-2         utf8_1.2.4                  ##  [91] tidyr_1.3.1                 generics_0.1.3              ##  [93] S4Arrays_1.4.1              httr_1.4.7                  ##  [95] htmlwidgets_1.6.4           uwot_0.2.2                  ##  [97] pkgconfig_2.0.3             gtable_0.3.5                ##  [99] ComplexHeatmap_2.20.0       lmtest_0.9-40               ## [101] XVector_0.44.0              htmltools_0.5.8.1           ## [103] dotCall64_1.1-1             clue_0.3-65                 ## [105] scales_1.3.0                png_0.1-8                   ## [107] spatstat.univar_3.0-1       knitr_1.48                  ## [109] rstudioapi_0.16.0           reshape2_1.4.4              ## [111] rjson_0.2.22                nlme_3.1-164                ## [113] curl_5.2.2                  cachem_1.1.0                ## [115] zoo_1.8-12                  GlobalOptions_0.1.2         ## [117] stringr_1.5.1               KernSmooth_2.23-24          ## [119] miniUI_0.1.1.1              desc_1.4.3                  ## [121] pillar_1.9.0                grid_4.4.1                  ## [123] vctrs_0.6.5                 promises_1.3.0              ## [125] xtable_1.8-4                evaluate_0.24.0             ## [127] cli_3.6.3                   compiler_4.4.1              ## [129] rlang_1.1.4                 crayon_1.5.3                ## [131] future.apply_1.11.2         labeling_0.4.3              ## [133] plyr_1.8.9                  fs_1.6.4                    ## [135] stringi_1.8.4               viridisLite_0.4.2           ## [137] deldir_2.0-4                gridBase_0.4-7              ## [139] munsell_0.5.1               lazyeval_0.2.2              ## [141] spatstat.geom_3.3-2         RcppHNSW_0.6.0              ## [143] patchwork_1.2.0             sparseMatrixStats_1.16.0    ## [145] future_1.34.0               shiny_1.9.1                 ## [147] highr_0.11                  SummarizedExperiment_1.34.0 ## [149] ROCR_1.0-11                 gargle_1.5.2                ## [151] igraph_2.0.3                bslib_0.8.0"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/TrainRecoveryModels.html","id":"development-of-se-recovery-model","dir":"Articles","previous_headings":"","what":"Development of SE recovery model","title":"Development of NMF Models for Spatial Ecotype Recovery","text":"performing Spatial EcoTyper analysis, users can develop machine learning model recover spatial ecotypes (SEs) various types gene expression data, including spatial transcriptomics single-cell RNA-seq. tutorial, use Vizgen MERSCOPE data two samples demonstrate training process. gene expression matrices, cell type SE annotations required training can obtained . First load required packages vignette","code":"suppressPackageStartupMessages(library(googledrive)) suppressPackageStartupMessages(library(Seurat)) suppressPackageStartupMessages(library(NMF)) suppressPackageStartupMessages(library(data.table)) suppressPackageStartupMessages(library(dplyr)) library(SpatialEcoTyper)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/TrainRecoveryModels.html","id":"loading-data","dir":"Articles","previous_headings":"Development of SE recovery model","what":"Loading data","title":"Development of NMF Models for Spatial Ecotype Recovery","text":"Download data Google Drive Load gene expression matrix Load cell type SE annotations","code":"drive_deauth() # Disable Google sign-in requirement drive_download(as_id(\"17mbc56M0GTq-9MR0GqHas-L-yIXdnxtu\"), \"HumanMelanomaPatient1_subset_counts.tsv.gz\", overwrite = TRUE) drive_download(as_id(\"17nL0ceONPw8ByAtDe34DiXiGLMVBLlPX\"), \"HumanColonCancerPatient2_subset_counts.tsv.gz\", overwrite = TRUE) drive_download(as_id(\"18HsreR4QH6hh5L-YO7toP9lg62dVv8iX\"), \"MultiSE_metadata_final.tsv\", overwrite = TRUE) ## Read the expression matrix for the first sample scdata <- fread(\"HumanMelanomaPatient1_subset_counts.tsv.gz\",                  sep = \"\\t\",header = TRUE, data.table = FALSE) rownames(scdata) <- scdata[, 1]  ## set the first column as row names scdata <- scdata[, -1]  ## drop the first column scdata <- NormalizeData(scdata)  ## Normalize the expression matrix  ## Read the expression matrix for the second sample scdata2 <- fread(\"HumanColonCancerPatient2_subset_counts.tsv.gz\",                  sep = \"\\t\",header = TRUE, data.table = FALSE) rownames(scdata2) <- scdata2[, 1]  ## set the first column as row names scdata2 <- scdata2[, -1]  ## drop the first column scdata2 <- NormalizeData(scdata2)  ## Normalize the expression matrix  ## Combine the two expression matrices genes <- intersect(rownames(scdata), rownames(scdata2)) scdata <- cbind(scdata[genes, ], scdata2[genes, ]) head(scdata[, 1:5]) ##          HumanMelanomaPatient1__cell_3655 HumanMelanomaPatient1__cell_3657 ## PDK4                             0.000000                         4.221184 ## TNFRSF17                         0.000000                         0.000000 ## ICAM3                            0.000000                         0.000000 ## FAP                              3.552438                         0.000000 ## GZMB                             0.000000                         0.000000 ## TSC2                             0.000000                         0.000000 ##          HumanMelanomaPatient1__cell_3658 HumanMelanomaPatient1__cell_3660 ## PDK4                             3.208945                                0 ## TNFRSF17                         0.000000                                0 ## ICAM3                            0.000000                                0 ## FAP                              0.000000                                0 ## GZMB                             0.000000                                0 ## TSC2                             0.000000                                0 ##          HumanMelanomaPatient1__cell_3661 ## PDK4                                    0 ## TNFRSF17                                0 ## ICAM3                                   0 ## FAP                                     0 ## GZMB                                    0 ## TSC2                                    0 ## Load the single-cell meta data derived from MultiSpatialEcoTyper analysis scmeta <- read.table(\"MultiSE_metadata_final.tsv\", sep = \"\\t\",                       header = TRUE, row.names = 1) scmeta$SE[is.na(scmeta$SE)] = \"nonSE\" ## cells with NA predictions were assigned into the NonSE group  ## Matches the row names of meta data and column names of expression matrix cells <- intersect(colnames(scdata), rownames(scmeta)) scdata <- scdata[, cells] scmeta <- scmeta[cells, ] head(scmeta[, c(\"Sample\", \"CellType\", \"SE\")]) ##                                  Sample   CellType  SE ## HumanMelanomaPatient1__cell_3655   SKCM Fibroblast SE3 ## HumanMelanomaPatient1__cell_3657   SKCM Fibroblast SE4 ## HumanMelanomaPatient1__cell_3658   SKCM Fibroblast SE4 ## HumanMelanomaPatient1__cell_3660   SKCM Fibroblast SE4 ## HumanMelanomaPatient1__cell_3661   SKCM Fibroblast SE3 ## HumanMelanomaPatient1__cell_3663   SKCM Fibroblast SE3"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/TrainRecoveryModels.html","id":"training","dir":"Articles","previous_headings":"Development of SE recovery model","what":"Training","title":"Development of NMF Models for Spatial Ecotype Recovery","text":"NMFGenerateWList function used train cell-type specific NMF models recovering SEs. Prior NMF, gene scaled mean 0 unit variance within cell type-specific expression matrix. satisfy non-negativity requirement NMF, cell type-specific expression matrices individually processed using posneg transformation, converts expression matrix two matrices, one containing positive values containing negative values sign inverted. two matrices subsequently concatenated produce training data. NMFGenerateWList function return list feature × SE matrices, representing cell type-specific gene signature matrix rows features columns SEs. Note: default, NMFGenerateWList selects top 2000 variable features (nfeature argument) -samples 2500 cells (downsample argument) within cell type training. training, retains 50 genes per SE (nfeature.per.se argument) model. Users can tune parameters accordingly. resulting W matrices used recover SEs spatial transcriptomics single-cell RNA-seq using RecoverSE function. detailed documentation SE recovery available Recovery Spatial Ecotypes Single-Cell Gene Expression Data Recovery Spatial Ecotypes Spatial Transcriptomics Data.","code":"# training Ws = NMFGenerateWList(scdata, scmeta,                        CellType = \"CellType\",                       SE = \"SE\", Sample = \"Sample\") ## This step would take ~3 mins for the demo. class(Ws) ## [1] \"list\" names(Ws) ## [1] \"B\"           \"CD4T\"        \"CD8T\"        \"DC\"          \"Endothelial\" ## [6] \"Fibroblast\"  \"Macrophage\"  \"NK\"          \"Plasma\" head(Ws[[2]]) ##                   SE1       SE5       SE6      SE10       SE8       SE3 ## FOXP3__pos  0.4719930 0.4885273 0.3651733 0.6901381 0.8495508 0.5111029 ## CCL5__neg   0.4636977 0.5029325 0.4671653 0.5279928 0.6660964 0.5879144 ## NFKB2__neg  0.5959560 0.5353461 0.3610576 0.4095969 0.5328200 0.6356051 ## NFKBIA__neg 0.5449949 0.5124919 0.4053110 0.3867929 0.4872992 0.5444012 ## XBP1__neg   0.3641057 0.4390831 0.4536565 0.5994809 0.6964391 0.4286859 ## IRF3__neg   0.4771004 0.4980158 0.4737179 0.5178389 0.4861118 0.4835203 ##                   SE4       SE9       SE2       SE7 ## FOXP3__pos  0.7223714 0.4173739 0.5810581 0.5287318 ## CCL5__neg   0.7176785 0.3887930 0.5669015 0.7065557 ## NFKB2__neg  0.7882044 0.4825905 1.0177761 0.1657350 ## NFKBIA__neg 0.5245634 0.4819461 0.9273532 0.7001782 ## XBP1__neg   0.4714610 0.5722981 0.6128531 0.8757327 ## IRF3__neg   0.4070195 0.5213065 0.6902136 0.9023205"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/TrainRecoveryModels.html","id":"development-of-se-deconvolution-model","dir":"Articles","previous_headings":"","what":"Development of SE deconvolution model","title":"Development of NMF Models for Spatial Ecotype Recovery","text":"Users can also develop NMF model deconvolve SEs bulk gene expression data. training data can pseudo-bulk mixtures aggregating single-cell transcriptomics. tutorial, create pseudo-bulk mixtures single-cell RNA-seq data melanoma sample. raw count sample available WU2161_counts.tsv SE recovery results available WU2161_RecoveredSEs.tsv.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/TrainRecoveryModels.html","id":"loading-data-1","dir":"Articles","previous_headings":"Development of SE deconvolution model","what":"Loading data","title":"Development of NMF Models for Spatial Ecotype Recovery","text":"Note: demonstration purposes, used 1,337 cells grouped SEs create pseudo-bulk mixtures. limited cell number offers basic example, fully capture diverse characteristics SEs, potentially affecting robustness model training subsequent SE recovery. practice, recommend using comprehensive dataset accurately reflects properties SEs, ensuring training process results reliable recovery model.","code":"# Download single-cell gene expression matrix and SE recovery results. # The downloads should be finished within 1min. drive_download(as_id(\"17VAeOnz6vTt2s0ZeTrK1kITdJ3Yus4ei\"), \"WU2161_counts.tsv\", overwrite = TRUE) drive_download(as_id(\"17kFjOHhmWxWAKm-LDqy6wV27o5lvz8L2\"), \"WU2161_RecoveredSEs.tsv\", overwrite = TRUE) # Load single-cell gene expression matrix. counts = fread(\"WU2161_counts.tsv\", sep = \"\\t\", data.table = FALSE) rownames(counts) = counts[, 1] ## Set the first column as row names counts = counts[, -1] ## Drop the first column head(counts[, 1:5]) ##            AAACCTGCACATGACT-1 AAACCTGGTGGTCCGT-1 AAACCTGGTTTGTGTG-1 ## AL627309.1                  0                  0                  0 ## AL627309.5                  0                  0                  0 ## AP006222.2                  0                  0                  0 ## AC114498.1                  0                  0                  0 ## AL669831.2                  0                  0                  0 ## LINC01409                   0                  0                  0 ##            AAACCTGTCCGATATG-1 AAACCTGTCTAACGGT-1 ## AL627309.1                  0                  0 ## AL627309.5                  1                  0 ## AP006222.2                  0                  0 ## AC114498.1                  0                  0 ## AL669831.2                  0                  0 ## LINC01409                   0                  0 # Load SE recovery results SEs = read.table(\"WU2161_RecoveredSEs.tsv\", sep = \"\\t\", row.names = 1, header = TRUE) SEs = SEs[match(colnames(counts), rownames(SEs)), 1] # extract SE predictions length(SEs) ## [1] 1337 table(SEs) ## SEs ## nonSE   SE1   SE2   SE3   SE4   SE5   SE6   SE7   SE8   SE9  ##   912    71    45    24     5    43    74    75    71    17"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/TrainRecoveryModels.html","id":"creating-pseudobulk-data","dir":"Articles","previous_headings":"Development of SE deconvolution model","what":"Creating pseudobulk data","title":"Development of NMF Models for Spatial Ecotype Recovery","text":"CreatePseudobulks function used create pseudo-bulk mixtures single-cell (spatial) transcriptomics data cells grouped SEs. samples cell fractions Gaussian distribution, sets negative fractions 0 re-normalizes fractions sum 1 across SEs. Based resulting fractions, samples 1,000 cells per pseudo-bulk mixture replacement, aggregates transcriptomes non-log linear space, normalize resulting mixture logarithm CPM using Seurat’s NormalizeData.","code":"result = CreatePseudobulks(counts = counts, groups = SEs, n_mixtures = 100) ## This step took ~4 min for the demo. head(result$Mixtures[, 1:5]) ## Gene expression matrix of pseudobulks ##            Pseudobulk1  Pseudobulk2 Pseudobulk3  Pseudobulk4  Pseudobulk5 ## AL627309.1 0.020129003 0.0166225359 0.023307824 0.0098541618 0.0088996542 ## AL627309.5 0.042782118 0.0507958729 0.065149253 0.0307522233 0.0470043992 ## AP006222.2 0.001258585 0.0047970105 0.002820776 0.0005117182 0.0027994077 ## AC114498.1 0.001848058 0.0009235317 0.002770807 0.0018443685 0.0009235317 ## AL669831.2 0.000000000 0.0000000000 0.000000000 0.0000000000 0.0000000000 ## LINC01409  0.028300784 0.0323725374 0.042793627 0.0507739102 0.0274993034 head(result$Fracs) ## SE fractions in pseudobulks ##                  nonSE        SE1        SE2        SE3         SE4        SE5 ## Pseudobulk1 0.16490065 0.04918395 0.04180656 0.13380601 0.108023707 0.10246218 ## Pseudobulk2 0.06857820 0.14872621 0.11331726 0.11852688 0.051279421 0.09434107 ## Pseudobulk3 0.08345357 0.17803366 0.19856639 0.00000000 0.002316577 0.04424433 ## Pseudobulk4 0.09014638 0.07754488 0.06834655 0.06010091 0.080744805 0.11287459 ## Pseudobulk5 0.12412216 0.00000000 0.05709886 0.11705402 0.102333027 0.21175799 ## Pseudobulk6 0.04653528 0.07215946 0.05076475 0.13719262 0.114854678 0.17734928 ##                    SE6        SE7        SE8        SE9 ## Pseudobulk1 0.15013277 0.11912636 0.09232816 0.03822966 ## Pseudobulk2 0.10492044 0.08010585 0.09546042 0.12474424 ## Pseudobulk3 0.15682092 0.15585820 0.03024719 0.15045916 ## Pseudobulk4 0.13277544 0.06254595 0.17260478 0.14231574 ## Pseudobulk5 0.06920083 0.04372533 0.22512173 0.04958606 ## Pseudobulk6 0.06965773 0.16811845 0.02792748 0.13544026"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/TrainRecoveryModels.html","id":"training-1","dir":"Articles","previous_headings":"Development of SE deconvolution model","what":"Training","title":"Development of NMF Models for Spatial Ecotype Recovery","text":"NMFGenerateW function used train NMF model SE deconvolution based provided SE fractions gene expression matrix. applying NMF, gene’s expression scaled mean 0 unit variance default. meet non-negativity requirement NMF, expression matrix transformed using posneg method. transformation splits expression matrix two matrices: one containing positive values containing absolute values negative values. two matrices concatenated form final training data NMF model. Note: default, NMFGenerateW selects top 2000 variable features (nfeature argument) training. training, retains 50 genes per SE (nfeature.per.se argument) model. Users can tune parameters accordingly. resulting W matrix can used infer SE abundances bulk gene expression profiles using DeconvoluteSE function. detailed documentation SE deconvolution available Recovery Spatial Ecotypes Bulk Gene Expression Data.","code":"W = NMFGenerateW(result$Fracs, result$Mixtures) ## This step took less than 1 min for the demo. head(W) ##                       nonSE          SE1          SE2          SE3          SE4 ## IGLV1-40__pos  6.435004e-02 2.220446e-16 2.220446e-16 2.220446e-16 2.220446e-16 ## IGHV4-34__pos  2.220446e-16 2.220446e-16 1.352908e-07 1.027098e-12 2.220446e-16 ## IGLV2-14__pos  4.468224e+00 2.220446e-16 1.323646e-15 2.220446e-16 1.962789e-01 ## IGKV2D-30__pos 1.061495e-15 2.220446e-16 6.075700e-01 1.292995e-15 1.082039e-15 ## IGKV1-33__pos  2.220446e-16 2.220446e-16 1.326303e-08 2.206336e-12 2.220446e-16 ## NLRP3__pos     2.220446e-16 2.220446e-16 2.220446e-16 2.220446e-16 2.220446e-16 ##                         SE5          SE6          SE7          SE8          SE9 ## IGLV1-40__pos  1.003067e-06 2.220446e-16 4.618030e+00 9.300405e-10 2.220446e-16 ## IGHV4-34__pos  1.264496e-11 2.220446e-16 4.671389e+00 2.220446e-16 2.220446e-16 ## IGLV2-14__pos  2.220446e-16 2.220446e-16 2.220446e-16 5.860832e-09 2.220446e-16 ## IGKV2D-30__pos 2.220446e-16 2.220446e-16 4.054420e+00 2.220446e-16 4.717884e-13 ## IGKV1-33__pos  2.841738e-12 2.220446e-16 4.649631e+00 2.220446e-16 3.816478e-16 ## NLRP3__pos     2.220446e-16 4.617904e+00 2.220446e-16 2.220446e-16 2.220446e-16 ## Save the model for late use. saveRDS(W, \"SE_Deconvolution_W.rds\")"},{"path":"https://digitalcytometry.github.io/spatialecotyper/articles/TrainRecoveryModels.html","id":"session-info","dir":"Articles","previous_headings":"","what":"Session info","title":"Development of NMF Models for Spatial Ecotype Recovery","text":"session info allows users replicate exact environment identify potential discrepancies package versions configurations might causing problems.","code":"sessionInfo() ## R version 4.4.1 (2024-06-14) ## Platform: aarch64-apple-darwin20 ## Running under: macOS 15.1 ##  ## Matrix products: default ## BLAS:   /Library/Frameworks/R.framework/Versions/4.4-arm64/Resources/lib/libRblas.0.dylib  ## LAPACK: /Library/Frameworks/R.framework/Versions/4.4-arm64/Resources/lib/libRlapack.dylib;  LAPACK version 3.12.0 ##  ## locale: ## [1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8 ##  ## time zone: America/Los_Angeles ## tzcode source: internal ##  ## attached base packages: ## [1] parallel  stats     graphics  grDevices utils     datasets  methods   ## [8] base      ##  ## other attached packages: ##  [1] SpatialEcoTyper_1.0.0 RANN_2.6.2            Matrix_1.7-0          ##  [4] dplyr_1.1.4           data.table_1.16.0     NMF_0.28              ##  [7] Biobase_2.64.0        BiocGenerics_0.50.0   cluster_2.1.6         ## [10] rngtools_1.5.2        registry_0.5-1        Seurat_5.1.0          ## [13] SeuratObject_5.0.2    sp_2.1-4              googledrive_2.1.1     ##  ## loaded via a namespace (and not attached): ##   [1] RColorBrewer_1.1-3     shape_1.4.6.1          rstudioapi_0.16.0      ##   [4] jsonlite_1.8.8         magrittr_2.0.3         spatstat.utils_3.1-0   ##   [7] rmarkdown_2.28         GlobalOptions_0.1.2    fs_1.6.4               ##  [10] ragg_1.3.2             vctrs_0.6.5            ROCR_1.0-11            ##  [13] spatstat.explore_3.3-2 htmltools_0.5.8.1      curl_5.2.2             ##  [16] sass_0.4.9             sctransform_0.4.1      parallelly_1.38.0      ##  [19] KernSmooth_2.23-24     bslib_0.8.0            htmlwidgets_1.6.4      ##  [22] desc_1.4.3             ica_1.0-3              plyr_1.8.9             ##  [25] plotly_4.10.4          zoo_1.8-12             cachem_1.1.0           ##  [28] igraph_2.0.3           iterators_1.0.14       mime_0.12              ##  [31] lifecycle_1.0.4        pkgconfig_2.0.3        R6_2.5.1               ##  [34] fastmap_1.2.0          clue_0.3-65            fitdistrplus_1.2-1     ##  [37] future_1.34.0          shiny_1.9.1            digest_0.6.37          ##  [40] colorspace_2.1-1       S4Vectors_0.42.1       patchwork_1.2.0        ##  [43] tensor_1.5             RSpectra_0.16-2        irlba_2.3.5.1          ##  [46] textshaping_0.4.0      progressr_0.14.0       fansi_1.0.6            ##  [49] spatstat.sparse_3.1-0  httr_1.4.7             polyclip_1.10-7        ##  [52] abind_1.4-5            compiler_4.4.1         gargle_1.5.2           ##  [55] withr_3.0.1            doParallel_1.0.17      fastDummies_1.7.4      ##  [58] R.utils_2.12.3         MASS_7.3-60.2          rjson_0.2.22           ##  [61] tools_4.4.1            lmtest_0.9-40          httpuv_1.6.15          ##  [64] future.apply_1.11.2    goftest_1.2-3          R.oo_1.26.0            ##  [67] glue_1.7.0             nlme_3.1-164           promises_1.3.0         ##  [70] grid_4.4.1             gridBase_0.4-7         Rtsne_0.17             ##  [73] reshape2_1.4.4         generics_0.1.3         gtable_0.3.5           ##  [76] spatstat.data_3.1-2    R.methodsS3_1.8.2      tidyr_1.3.1            ##  [79] utf8_1.2.4             spatstat.geom_3.3-2    RcppAnnoy_0.0.22       ##  [82] foreach_1.5.2          ggrepel_0.9.6          pillar_1.9.0           ##  [85] stringr_1.5.1          spam_2.10-0            RcppHNSW_0.6.0         ##  [88] later_1.3.2            circlize_0.4.16        splines_4.4.1          ##  [91] lattice_0.22-6         survival_3.6-4         deldir_2.0-4           ##  [94] tidyselect_1.2.1       ComplexHeatmap_2.20.0  miniUI_0.1.1.1         ##  [97] pbapply_1.7-2          knitr_1.48             gridExtra_2.3          ## [100] IRanges_2.38.1         scattermore_1.2        stats4_4.4.1           ## [103] xfun_0.47              matrixStats_1.4.1      stringi_1.8.4          ## [106] lazyeval_0.2.2         yaml_2.3.10            evaluate_0.24.0        ## [109] codetools_0.2-20       tibble_3.2.1           BiocManager_1.30.25    ## [112] cli_3.6.3              uwot_0.2.2             xtable_1.8-4           ## [115] reticulate_1.39.0      systemfonts_1.1.0      munsell_0.5.1          ## [118] jquerylib_0.1.4        Rcpp_1.0.13            globals_0.16.3         ## [121] spatstat.random_3.3-1  png_0.1-8              spatstat.univar_3.0-1  ## [124] pkgdown_2.1.0          ggplot2_3.5.1          dotCall64_1.1-1        ## [127] listenv_0.9.1          viridisLite_0.4.2      scales_1.3.0           ## [130] ggridges_0.5.6         crayon_1.5.3           leiden_0.4.3.1         ## [133] purrr_1.0.2            GetoptLong_1.0.5       rlang_1.1.4            ## [136] cowplot_1.1.3"},{"path":"https://digitalcytometry.github.io/spatialecotyper/authors.html","id":null,"dir":"","previous_headings":"","what":"Authors","title":"Authors and Citation","text":"Wubing Zhang. Author, maintainer.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/authors.html","id":"citation","dir":"","previous_headings":"","what":"Citation","title":"Authors and Citation","text":"Zhang W (2024). SpatialEcoTyper: Spatial ecotype analaysis. R package version 1.0.0, https://digitalcytometry.github/spatialecotyper.","code":"@Manual{,   title = {SpatialEcoTyper: Spatial ecotype analaysis},   author = {Wubing Zhang},   year = {2024},   note = {R package version 1.0.0},   url = {https://digitalcytometry.github/spatialecotyper}, }"},{"path":"https://digitalcytometry.github.io/spatialecotyper/index.html","id":"deciphering-spatial-ecotypes-from-spatial-single-cell-and-bulk-transcriptomic-data","dir":"","previous_headings":"","what":"Spatial ecotype analaysis","title":"Spatial ecotype analaysis","text":"Spatial EcoTyper versatile framework designed systematic identification spatial cellular communities, termed spatial ecotypes, single-cell spatial transcriptomics data. addition, provides unified methods recovery spatial ecotypes across multiple data modalities, including spatial transcriptomics, single-cell RNA-seq, bulk transcriptomic datasets.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/index.html","id":"overview-of-spatial-ecotyper","dir":"","previous_headings":"","what":"Overview of Spatial EcoTyper","title":"Spatial ecotype analaysis","text":"Spatial EcoTyper available R package, comprehensive documentation accessible https://digitalcytometry.github.io/spatialecotyper. Additionally, Spatial EcoTyper can used via web platform https://spatialecotyper.stanford.edu/ (available soon), user-friendly interface recovering spatial ecotypes various data sources, including spatial transcriptomics (e.g. MERSCOPE, Visium, etc), single-cell RNA-seq, bulk gene expression datasets. provide 6 comprehensive tutorials illustrating functionalities included SpatialEcoTyper R package. first tutorial demonstrates identify spatial ecotypes single-cell spatial transcriptomics data. second demonstrates identified conserved spatial ecotypes across multiple samples. third demonstrates develop NMF models recovery spatial ecotypes unseen data. remaining tutorials introduce recover spatial ecotypes spatial transcriptomics, scRNA-seq, bulk RNA-seq datasets. Tutorial 1: Discovery Spatial Ecotypes Single Sample Tutorial 2: Discovery Spatial Ecotypes Multiple Samples Tutorial 3: Development NMF Models Spatial Ecotype Recovery Tutorial 4: Recovery Spatial Ecotypes Spatial Transcriptomics Data Tutorial 5: Recovery Spatial Ecotypes Single-Cell Gene Expression Data Tutorial 6: Recovery Spatial Ecotypes Bulk Gene Expression Data Note: Spatial EcoTyper depends extensively Seurat key processes like dimensionality reduction, UMAP embedding, clustering, visualization. Initially developed using Seurat v4.3, tool thoroughly tested validated Seurat v5. Although UMAP embeddings clustering results show slight differences Seurat v4 v5, overall consistency remains strong, ensuring core biological insights preserved across versions.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/index.html","id":"installation","dir":"","previous_headings":"","what":"Installation","title":"Spatial ecotype analaysis","text":"Spatial EcoTyper available R package can installed via BiocManager package directly R console. ERROR: dependency ‘GetoptLong’ available package ‘ComplexHeatmap’ installation within R console fails, can try installing necessary packages via conda install mamba install. Failed install ‘presto’ GitHub: HTTP error 401. Bad credentials resolve issue, ’ll need authenticate using personal access token (PAT). can generate GitHub personal access token following GitHub’s documentation. generating token, set environment variable R using following code. Replace “YOUR_TOKEN” actual token: source code Spatial EcoTyper available https://github.com/digitalcytometry/spatialecotyper. downloading package, can install source code using command:","code":"if(!\"BiocManager\" %in% installed.packages()){   install.packages(\"BiocManager\") }  ## Install dependencies BiocManager::install(c(\"remotes\", \"Seurat\", \"NMF\", \"dplyr\", \"pals\",                        \"data.table\", \"ComplexHeatmap\", \"googledrive\",                         \"glmGamPoi\", \"immunogenomics/presto\"))  ## Install SpatialEcoTyper BiocManager::install(\"digitalcytometry/spatialecotyper\") conda install bioconda::bioconductor-complexheatmap ## Set the token in your R environment: Sys.setenv(GITHUB_PAT=\"YOUR_TOKEN\")  ## Install the package from GitHub: BiocManager::install(\"immunogenomics/presto\") install.packages(\"SpatialEcoTyper.tar.gz\", repos = NULL)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/index.html","id":"contribution","dir":"","previous_headings":"","what":"Contribution","title":"Spatial ecotype analaysis","text":"encounter bugs suggestions improvements, please feel free open issue submit pull request. feedback contributions help us make tool better everyone.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/index.html","id":"license","dir":"","previous_headings":"","what":"License","title":"Spatial ecotype analaysis","text":"Please see LICENSE file.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/index.html","id":"authors","dir":"","previous_headings":"","what":"Authors","title":"Spatial ecotype analaysis","text":"Spatial EcoTyper developed Newman Lab Wubing Zhang.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/index.html","id":"citation","dir":"","previous_headings":"","what":"Citation","title":"Spatial ecotype analaysis","text":"use Spatial EcoTyper, please cite:","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/AnnotateCells.html","id":null,"dir":"Reference","previous_headings":"","what":"Extract Spatial Ecotype Annotations for Single Cells — AnnotateCells","title":"Extract Spatial Ecotype Annotations for Single Cells — AnnotateCells","text":"function adds spatial ecotype annotations metadata single cells.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/AnnotateCells.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Extract Spatial Ecotype Annotations for Single Cells — AnnotateCells","text":"","code":"AnnotateCells(scmeta, obj)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/AnnotateCells.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Extract Spatial Ecotype Annotations for Single Cells — AnnotateCells","text":"scmeta Data frame containing single-cell metadata. Two columns (X Y) spatial coordinates required. obj Seurat object returned SpatialEcoTyper function.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/AnnotateCells.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Extract Spatial Ecotype Annotations for Single Cells — AnnotateCells","text":"modified version `scmeta` spatial ecotype annotations added.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/AnnotateCells.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Extract Spatial Ecotype Annotations for Single Cells — AnnotateCells","text":"","code":"library(data.table) #>  #> Attaching package: ‘data.table’ #> The following objects are masked from ‘package:dplyr’: #>  #>     between, first, last library(Seurat) library(SpatialEcoTyper) library(googledrive) drive_deauth() # no Google sign-in is required ## Download a single-cell meta data drive_download(as_id(\"1CgUOQKrWY_TG61o5aw7J9LZzE20D6NuI\"),                     \"HumanMelanomaPatient1_subset_scmeta.tsv\",                      overwrite = TRUE) #> File downloaded: #> • HumanMelanomaPatient1_subset_scmeta.tsv #>    #> Saved locally as: #> • HumanMelanomaPatient1_subset_scmeta.tsv ## Obtain a Seurat object from SpatialEcoTyper result drive_download(as_id(\"1nSPj2zRywFUdbo1fwiz77ds4NuM6bmV2\"),               \"Melanoma1_subset_SpatialEcoTyper_results.rds\", overwrite = TRUE) #> Error in map(as_id(id), get_one_file_id): ℹ In index: 1. #> Caused by error in `.f()`: #> ! Client error: (404) Not Found #> File not found: 1nSPj2zRywFUdbo1fwiz77ds4NuM6bmV2. #> • message: File not found: 1nSPj2zRywFUdbo1fwiz77ds4NuM6bmV2. #> • domain: global #> • reason: notFound #> • location: fileId #> • locationType: parameter  scmeta <- read.table(\"HumanMelanomaPatient1_subset_scmeta.tsv\",                      sep = \"\\t\", header = TRUE, row.names = 1) head(scmeta) #>                                         X         Y   CellType CellTypeName #> HumanMelanomaPatient1__cell_3655 1894.706 -6367.766 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3657 1942.480 -6369.602 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3658 1963.007 -6374.026 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3660 1981.600 -6372.266 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3661 1742.939 -6374.851 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3663 1921.683 -6383.309 Fibroblast  Fibroblasts #>                                  Region Dist2Interface #> HumanMelanomaPatient1__cell_3655 Stroma      -883.1752 #> HumanMelanomaPatient1__cell_3657 Stroma      -894.8463 #> HumanMelanomaPatient1__cell_3658 Stroma      -904.1115 #> HumanMelanomaPatient1__cell_3660 Stroma      -907.8909 #> HumanMelanomaPatient1__cell_3661 Stroma      -874.2712 #> HumanMelanomaPatient1__cell_3663 Stroma      -903.6559 obj <- readRDS(\"Melanoma1_subset_SpatialEcoTyper_results.rds\")$obj  ## Transfer SE annotations to single cells scmeta <- AnnotateCells(scmeta = scmeta, obj = obj) head(scmeta) #>                                         X         Y   CellType CellTypeName #> HumanMelanomaPatient1__cell_3655 1894.706 -6367.766 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3657 1942.480 -6369.602 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3658 1963.007 -6374.026 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3660 1981.600 -6372.266 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3661 1742.939 -6374.851 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3663 1921.683 -6383.309 Fibroblast  Fibroblasts #>                                  Region Dist2Interface  SE #> HumanMelanomaPatient1__cell_3655 Stroma      -883.1752 SE5 #> HumanMelanomaPatient1__cell_3657 Stroma      -894.8463 SE7 #> HumanMelanomaPatient1__cell_3658 Stroma      -904.1115 SE7 #> HumanMelanomaPatient1__cell_3660 Stroma      -907.8909 SE7 #> HumanMelanomaPatient1__cell_3661 Stroma      -874.2712 SE0 #> HumanMelanomaPatient1__cell_3663 Stroma      -903.6559 SE5"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/ComputeAvg.html","id":null,"dir":"Reference","previous_headings":"","what":"Compute Cell-Type-Specific Average Expression of Spatial Clusters — ComputeAvg","title":"Compute Cell-Type-Specific Average Expression of Spatial Clusters — ComputeAvg","text":"Compute Cell-Type-Specific Average Expression Spatial Clusters","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/ComputeAvg.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Compute Cell-Type-Specific Average Expression of Spatial Clusters — ComputeAvg","text":"","code":"ComputeAvg(   normdata,   scmeta,   cluster = \"SE\",   Region = NULL,   scale = TRUE,   ncores = 4 )"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/ComputeAvg.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Compute Cell-Type-Specific Average Expression of Spatial Clusters — ComputeAvg","text":"normdata Numeric matrix normalized expression data, rows represent genes columns represent cells. scmeta Data frame containing metadata associated cell, including spatial cluster cell type annotations. cluster Character string specifying column name 'scmeta' containing spatial cluster annotations. Region Character string specifying column name metadata data frames containing region annotations (default: NULL). scale boolean specifying whether univariance normalization. ncores Integer specifying number CPU cores use parallel processing.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/ComputeAvg.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Compute Cell-Type-Specific Average Expression of Spatial Clusters — ComputeAvg","text":"matrix average expression, rows represent genes columns represent spatial clusters sample.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/ComputeAvg.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Compute Cell-Type-Specific Average Expression of Spatial Clusters — ComputeAvg","text":"","code":"library(data.table) library(Seurat) library(SpatialEcoTyper) library(googledrive) drive_deauth() # no Google sign-in is required drive_download(as_id(\"13Rc5Rsu8jbnEYYfUse-xQ7ges51LcI7n\"),                     \"HumanMelanomaPatient1_subset_counts.tsv.gz\",                     overwrite = TRUE, verbose = FALSE) drive_download(as_id(\"1GUbbEBttiu2ntVpaIcIK7YobaKKwbqnM\"),                     \"HumanMelanomaPatient1_subset_SpatialEcoTyper_results.rds\",                     overwrite = TRUE, verbose = FALSE) scdata <- fread(\"HumanMelanomaPatient1_subset_counts.tsv.gz\",                 sep = \"\\t\",header = TRUE, data.table = FALSE) rownames(scdata) <- scdata[, 1] scdata <- as.matrix(scdata[, -1]) tmpobj <- CreateSeuratObject(scdata) %>%         SCTransform(clip.range = c(-10, 10), verbose = FALSE) seurat_version = as.integer(gsub(\"\\\\..*\", \"\", as.character(packageVersion(\"Seurat\")))) if(seurat_version<5){   normdata <- GetAssayData(tmpobj, \"data\") }else{   normdata <- tmpobj[[\"SCT\"]]$data } metadata = readRDS(\"HumanMelanomaPatient1_subset_SpatialEcoTyper_results.rds\")$metadata  # Construct cell-type-specific gene expression signatures of SEs avgexprs <- ComputeAvg(normdata = normdata, scmeta = metadata) head(avgexprs) #>                             SE09        SE01        SE08         SE07 #> Fibroblast..PDK4      0.35259620  0.13410953  0.06966571  0.118335435 #> Fibroblast..TNFRSF17  0.00000000  0.00000000  0.00000000  0.000000000 #> Fibroblast..ICAM3     0.00000000  0.00000000  0.00000000  0.000000000 #> Fibroblast..FAP      -0.29331695  0.02505667 -0.07346211  0.077473474 #> Fibroblast..GZMB     -0.09797678 -0.04104210 -0.09082236 -0.002063296 #> Fibroblast..TSC2     -0.05899541 -0.02658523 -0.02690466 -0.016824868 #>                             SE04        SE03         SE06       SE02       SE05 #> Fibroblast..PDK4     -0.04187951 -0.18236328 -0.121186218 0.02876511 0.01315714 #> Fibroblast..TNFRSF17  0.00000000  0.00000000  0.000000000 0.00000000 0.00000000 #> Fibroblast..ICAM3     0.00000000  0.00000000  0.000000000 0.00000000 0.00000000 #> Fibroblast..FAP       0.05147663 -0.08659207  0.053183806 0.02960319 0.11607862 #> Fibroblast..GZMB      0.01127651  0.02282926 -0.009071706 0.03888278 0.04906746 #> Fibroblast..TSC2      0.02419604 -0.04820711 -0.001317502 0.07683963 0.09783272"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/ComputeAvgs.html","id":null,"dir":"Reference","previous_headings":"","what":"Compute Cell-Type-Specific Average Expression of Spatial Clusters — ComputeAvgs","title":"Compute Cell-Type-Specific Average Expression of Spatial Clusters — ComputeAvgs","text":"Compute Cell-Type-Specific Average Expression Spatial Clusters","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/ComputeAvgs.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Compute Cell-Type-Specific Average Expression of Spatial Clusters — ComputeAvgs","text":"","code":"ComputeAvgs(   normdata,   scmeta,   cluster = \"SE\",   Region = NULL,   scale = TRUE,   ncores = 4 )"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/ComputeAvgs.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Compute Cell-Type-Specific Average Expression of Spatial Clusters — ComputeAvgs","text":"normdata Numeric matrix normalized expression data, rows represent genes columns represent cells. scmeta Data frame containing metadata associated cell, including spatial cluster cell type annotations. cluster Character string specifying column name 'scmeta' containing spatial cluster annotations. Region Character string specifying column name metadata data frames containing region annotations (default: NULL). scale boolean specifying whether univariance normalization. ncores Integer specifying number CPU cores use parallel processing.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/ComputeAvgs.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Compute Cell-Type-Specific Average Expression of Spatial Clusters — ComputeAvgs","text":"matrix average expression, rows represent genes columns represent spatial clusters sample.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/ComputeAvgs.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Compute Cell-Type-Specific Average Expression of Spatial Clusters — ComputeAvgs","text":"","code":"library(data.table) library(Seurat) library(SpatialEcoTyper) library(googledrive) drive_deauth() # no Google sign-in is required drive_download(as_id(\"1CoQmU3u8MoVC8RbLUvTDQmOuJJ703HHB\"),               \"HumanMelanomaPatient1_subset_counts.tsv.gz\", overwrite = TRUE) #> File downloaded: #> • HumanMelanomaPatient1_subset_counts.tsv.gz #>    #> Saved locally as: #> • HumanMelanomaPatient1_subset_counts.tsv.gz drive_download(as_id(\"1nSPj2zRywFUdbo1fwiz77ds4NuM6bmV2\"),               \"Melanoma1_subset_SpatialEcoTyper_results.rds\", overwrite = TRUE) #> Error in map(as_id(id), get_one_file_id): ℹ In index: 1. #> Caused by error in `.f()`: #> ! Client error: (404) Not Found #> File not found: 1nSPj2zRywFUdbo1fwiz77ds4NuM6bmV2. #> • message: File not found: 1nSPj2zRywFUdbo1fwiz77ds4NuM6bmV2. #> • domain: global #> • reason: notFound #> • location: fileId #> • locationType: parameter scdata <- fread(\"HumanMelanomaPatient1_subset_counts.tsv.gz\",                 sep = \"\\t\",header = TRUE, data.table = FALSE) rownames(scdata) <- scdata[, 1] scdata <- as.matrix(scdata[, -1]) tmpobj <- CreateSeuratObject(scdata) %>%         SCTransform(clip.range = c(-10, 10), verbose = FALSE) #> Warning: Data is of class matrix. Coercing to dgCMatrix. seurat_version = as.integer(gsub(\"\\\\..*\", \"\", as.character(packageVersion(\"SeuratObject\")))) if(seurat_version<5){   normdata <- GetAssayData(tmpobj, \"data\") }else{   normdata <- tmpobj[[\"SCT\"]]$data } metadata = readRDS(\"Melanoma1_subset_SpatialEcoTyper_results.rds\")$metadata  # Construct cell-type-specific gene expression signatures of SEs avgexprs <- ComputeAvgs(normdata = normdata, scmeta = metadata) head(avgexprs) #>                               SE5         SE7         SE0         SE4 #> Fibroblast..PDK4      0.110804267  0.19775972  0.13120621 -0.04927833 #> Fibroblast..TNFRSF17  0.000000000  0.00000000  0.00000000  0.00000000 #> Fibroblast..ICAM3     0.000000000  0.00000000  0.00000000  0.00000000 #> Fibroblast..FAP       0.118792445 -0.13868930  0.05233653  0.03938155 #> Fibroblast..GZMB     -0.031686314 -0.07422975 -0.03297410  0.02567394 #> Fibroblast..TSC2     -0.001888106 -0.03091562 -0.02679740 -0.02925629 #>                              SE6         SE2          SE1         SE3 #> Fibroblast..PDK4     -0.13236092 -0.17959104 -0.025478747  0.01853931 #> Fibroblast..TNFRSF17  0.00000000  0.00000000  0.000000000  0.00000000 #> Fibroblast..ICAM3     0.00000000  0.00000000  0.000000000  0.00000000 #> Fibroblast..FAP       0.05003947 -0.10671133  0.035710822 -0.07657463 #> Fibroblast..GZMB      0.00161892  0.02988412 -0.001820212  0.04700560 #> Fibroblast..TSC2     -0.02869510 -0.05265459  0.117406740  0.13560073"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/ComputeFCs.html","id":null,"dir":"Reference","previous_headings":"","what":"Compute Cell-Type-Specific Fold Changes (FCs) for Spatial Clusters — ComputeFCs","title":"Compute Cell-Type-Specific Fold Changes (FCs) for Spatial Clusters — ComputeFCs","text":"function computes fold changes (FCs) spatial transcriptomic data, comparing expression levels spatial clusters within cell type.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/ComputeFCs.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Compute Cell-Type-Specific Fold Changes (FCs) for Spatial Clusters — ComputeFCs","text":"","code":"ComputeFCs(   normdata,   scmeta,   cluster = \"SE\",   Region = NULL,   scale = FALSE,   ncores = parallel::detectCores() )"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/ComputeFCs.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Compute Cell-Type-Specific Fold Changes (FCs) for Spatial Clusters — ComputeFCs","text":"normdata Numeric matrix normalized expression data, rows represent genes columns represent cells. scmeta Data frame containing metadata associated cell, including spatial cluster cell type annotations. cluster Character string specifying column name 'scmeta' containing spatial cluster annotations. Region Character string specifying column name metadata data frames containing region annotations (default: NULL). scale boolean specifying whether univariance normalization. ncores Integer specifying number CPU cores use parallel processing.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/ComputeFCs.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Compute Cell-Type-Specific Fold Changes (FCs) for Spatial Clusters — ComputeFCs","text":"matrix fold changes (FCs), rows represent genes columns represent spatial clusters sample.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/CreatePseudobulks.html","id":null,"dir":"Reference","previous_headings":"","what":"Create Pseudo-bulk Mixtures — CreatePseudobulks","title":"Create Pseudo-bulk Mixtures — CreatePseudobulks","text":"function generates pseudobulk samples aggregating single-cell transcriptomics.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/CreatePseudobulks.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Create Pseudo-bulk Mixtures — CreatePseudobulks","text":"","code":"CreatePseudobulks(data = NULL, groups, counts = NULL, n_mixtures = 100)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/CreatePseudobulks.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Create Pseudo-bulk Mixtures — CreatePseudobulks","text":"data matrix normalized gene expression data (genes x cells). NULL, counts must provided. groups named vector indicating group (e.g., spatial ecotype) cell. names correspond column names data matrix. counts matrix raw counts data (genes x cells). Used generate normalized data data provided. n_mixtures integer specifying number pseudobulk samples create. Default 100.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/CreatePseudobulks.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Create Pseudo-bulk Mixtures — CreatePseudobulks","text":"list containing two elements: Fracs matrix fractions group pseudobulk samples (rows represent pseudobulk samples, columns represent groups). Mixtures matrix pseudobulk gene expression data (genes x pseudobulk samples).","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/CreatePseudobulks.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Create Pseudo-bulk Mixtures — CreatePseudobulks","text":"`data` provided, function normalize `counts` matrix dividing column sum multiplying 10,000. maximum value `data` less 80, assumes data log2 scale converts back non-log scale. `groups` vector used ensure cells correctly assigned respective groups.   `groups` names, assumed names correspond column names `data` matrix. Pseudobulk samples created sampling cells group based predefined fractions,   calculating average expression gene pseudobulk samples. pseudobulk data normalized using Seurat's `NormalizeData` function.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/CreatePseudobulks.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Create Pseudo-bulk Mixtures — CreatePseudobulks","text":"","code":"library(SpatialEcoTyper) library(googledrive) drive_deauth() # no Google sign-in is required drive_download(as_id(\"15n9zlXed74oeGaO1pythOOM_iWIfuMn2\"), \"Melanoma_WU2161_counts.rds\",                     overwrite = TRUE) #> File downloaded: #> • Melanoma_WU2161_counts.rds  #> Saved locally as: #> • Melanoma_WU2161_counts.rds counts <- readRDS(\"Melanoma_WU2161_counts.rds\") ## raw counts of scRNA-seq data groups <- sample(paste0(\"SE\", 1:10), ncol(counts), replace = TRUE) names(groups) <- colnames(counts) result = CreatePseudobulks(counts = counts, groups = groups, n_mixtures = 20) head(result$Mixtures[, 1:5]) ## Gene expression matrix of pseudobulks #>            Pseudobulk1 Pseudobulk2  Pseudobulk3  Pseudobulk4  Pseudobulk5 #> AL627309.1 0.010074937 0.026466048 0.0171018497 0.0171069227 0.0255710058 #> AL627309.5 0.028185407 0.028121530 0.0440359686 0.0470177161 0.0566584344 #> AP006222.2 0.005813013 0.002907824 0.0051710095 0.0088178291 0.0068326888 #> AC114498.1 0.014872736 0.014857974 0.0069979292 0.0069840099 0.0069909626 #> AL669831.2 0.001482140 0.000000000 0.0003703704 0.0007391259 0.0003700004 #> LINC01409  0.038924808 0.030773482 0.0406855932 0.0485869241 0.0419149703 head(result$Fracs) ## SE fractions in pseudobulks #>                     SE1       SE10        SE2        SE3        SE4        SE5 #> Pseudobulk1 0.148299599 0.04084198 0.13605238 0.04812145 0.07334537 0.16468016 #> Pseudobulk2 0.180245105 0.03591520 0.03277197 0.16672719 0.17952414 0.11634038 #> Pseudobulk3 0.078572940 0.08653050 0.12737995 0.10409351 0.08368176 0.06809299 #> Pseudobulk4 0.073579654 0.20107738 0.10550911 0.11484678 0.07561444 0.11455294 #> Pseudobulk5 0.003943657 0.15120503 0.09552227 0.05698550 0.14124883 0.10354736 #> Pseudobulk6 0.067123736 0.11070905 0.15959928 0.07370885 0.15368544 0.06388965 #>                    SE6        SE7        SE8        SE9 #> Pseudobulk1 0.00000000 0.16123196 0.02122383 0.20620327 #> Pseudobulk2 0.03504460 0.11745721 0.00000000 0.13597421 #> Pseudobulk3 0.16320454 0.09041136 0.07594698 0.12208546 #> Pseudobulk4 0.04802129 0.16669192 0.05996442 0.04014206 #> Pseudobulk5 0.07907159 0.13299510 0.08381708 0.15166359 #> Pseudobulk6 0.16595165 0.01566788 0.13811904 0.05154544"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/DeconvoluteSE.html","id":null,"dir":"Reference","previous_headings":"","what":"Infer SE Abundances Using Pretrained NMF Model — DeconvoluteSE","title":"Infer SE Abundances Using Pretrained NMF Model — DeconvoluteSE","text":"function predicts SE abundances mixture.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/DeconvoluteSE.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Infer SE Abundances Using Pretrained NMF Model — DeconvoluteSE","text":"","code":"DeconvoluteSE(dat, scale = TRUE, W = NULL)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/DeconvoluteSE.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Infer SE Abundances Using Pretrained NMF Model — DeconvoluteSE","text":"dat numeric matrix bulk gene expression data. scale Logical indicating whether scale input data predictions. W W matrix inferring SE abundances bulk expression data.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/DeconvoluteSE.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Infer SE Abundances Using Pretrained NMF Model — DeconvoluteSE","text":"matrix SE abundances bulk tumors.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/DeconvoluteSE.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Infer SE Abundances Using Pretrained NMF Model — DeconvoluteSE","text":"","code":"library(googledrive) drive_deauth() # no Google sign-in is required drive_download(as_id(\"14QvmgISxaArTzWt_UHvf55aAYN2zm84Q\"), \"SKCM_RNASeqV2.geneExp.rds\",                     overwrite = TRUE) #> File downloaded: #> • SKCM_RNASeqV2.geneExp.rds  #> Saved locally as: #> • SKCM_RNASeqV2.geneExp.rds bulkdata <- readRDS(\"SKCM_RNASeqV2.geneExp.rds\")  # Predict SE abundances in bulk tumors se_abundances <- DeconvoluteSE(dat = bulkdata) head(se_abundances[, 1:5]) #>                      nonSE        SE1        SE2        SE3        SE4 #> TCGA-3N-A9WB-06 0.19380234 0.05372667 0.16735600 0.12581663 0.07216666 #> TCGA-3N-A9WC-06 0.05293689 0.13901340 0.08427617 0.08372047 0.04243859 #> TCGA-3N-A9WD-06 0.27200075 0.17114795 0.06288761 0.05641549 0.10166721 #> TCGA-BF-A1PU-01 0.16899510 0.13618971 0.06501306 0.09269615 0.17313296 #> TCGA-BF-A1PV-01 0.12078283 0.06921834 0.05970319 0.16813008 0.11059648 #> TCGA-BF-A1PX-01 0.21398415 0.04019509 0.08906215 0.04499893 0.08561680"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/GetPCList.html","id":null,"dir":"Reference","previous_headings":"","what":"Generate Principal Component (PC) List for Spatial Microregions — GetPCList","title":"Generate Principal Component (PC) List for Spatial Microregions — GetPCList","text":"function performs principal component analysis based cell-type-specific gene expression spatial microregions.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/GetPCList.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Generate Principal Component (PC) List for Spatial Microregions — GetPCList","text":"","code":"GetPCList(   mergedncem,   min.cells = 3,   min.features = 5,   nfeatures = 3000,   ncores = 1,   do.scale = TRUE )"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/GetPCList.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Generate Principal Component (PC) List for Spatial Microregions — GetPCList","text":"mergedncem matrix cell-type-specific gene expression data, rows representing genes columns representing spatial microregions cell type. min.cells Integer, minimum number non-zero counts required per gene retain gene analysis. Default 3. min.features Integer, minimum number features (genes) required per spatial microregion retain microregion analysis. Default 5. nfeatures Integer, number variable features select PCA. Default 3000. ncores Integer, number cores use parallel processing. Default 1. .scale Logical, whether scale data performing PCA. Default TRUE.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/GetPCList.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Generate Principal Component (PC) List for Spatial Microregions — GetPCList","text":"named list matrices, matrix contains PCs specific cell type. Cell types insufficient data excluded result.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/GetPCList.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Generate Principal Component (PC) List for Spatial Microregions — GetPCList","text":"function first filters input matrix based specified minimum number cells features. creates Seurat objects cell type, normalizes data, identifies variable features, scales data, performs PCA. resulting PCs cell type returned list.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/GetSNlist.html","id":null,"dir":"Reference","previous_headings":"","what":"Construct Cell-Type-Specific Similarity Network — GetSNList","title":"Construct Cell-Type-Specific Similarity Network — GetSNList","text":"function generates list similarity networks (SNs) given list embeddings. embeddings represent spatial microregions, function computes K-nearest neighbor (KNN) graphs based provided embeddings create similarity matrices.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/GetSNlist.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Construct Cell-Type-Specific Similarity Network — GetSNList","text":"","code":"GetSNList(emb_list, npcs = 20, k = 50, min.cts.per.region = 1, ncores = 1)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/GetSNlist.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Construct Cell-Type-Specific Similarity Network — GetSNList","text":"emb_list list matrices matrix contains embeddings single sample. rows correspond different principal components (PCs) features, columns correspond spatial regions cells. npcs integer specifying number principal components features use embedding matrix. Default 20. k integer specifying number nearest neighbors consider constructing KNN graph. Default 50. min.cts.per.region integer specifying minimum number distinct cell types must present spatial region retained analysis. Default 1. ncores integer specifying number cores use parallel computation. Default 1.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/GetSNlist.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Construct Cell-Type-Specific Similarity Network — GetSNList","text":"list sparse matrices matrix represents similarity network (SN) sample. rows columns matrix correspond spatial regions, values represent similarity scores.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/GetSNlist.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Construct Cell-Type-Specific Similarity Network — GetSNList","text":"function first trims input embeddings retain top `npcs` principal components features. filters spatial regions meet minimum cell type threshold. sample, function computes KNN graph using trimmed embeddings converts resulting distances similarity scores. Missing spatial regions filled zeros ensure samples regions.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/GetSpatialMetacells.html","id":null,"dir":"Reference","previous_headings":"","what":"Construct Spatial Metacells from Single-Cell Spatial Data — GetSpatialMetacells","title":"Construct Spatial Metacells from Single-Cell Spatial Data — GetSpatialMetacells","text":"function computes spatial metacells single-cell spatial transcriptomics. Spatial metacells represent aggregated expression profiles spatially proximal cells. function utilizes k-nearest neighbor (KNN) weighting aggregate expression profiles neighboring cells generate metacell expression profiles cell type.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/GetSpatialMetacells.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Construct Spatial Metacells from Single-Cell Spatial Data — GetSpatialMetacells","text":"","code":"GetSpatialMetacells(   normdata,   metadata,   X = \"X\",   Y = \"Y\",   CellType = \"CellType\",   k = 20,   radius = 50,   bin = \"SpotID\",   bin.X = \"Spot.X\",   bin.Y = \"Spot.Y\",   min.cells.per.region = 1,   ncores = 1 )"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/GetSpatialMetacells.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Construct Spatial Metacells from Single-Cell Spatial Data — GetSpatialMetacells","text":"normdata matrix data frame representing normalized gene expression data, rows correspond genes columns correspond cells. metadata data frame containing metadata associated cell. Must include spatial coordinates (e.g., X Y) well cell type annotations. row names metadata must match column names normdata. X Character string specifying column name metadata containing X spatial coordinates. Y Character string specifying column name metadata containing Y spatial coordinates. CellType Character string specifying column name metadata containing cell type annotations. k Integer specifying number nearest spatial neighbors constructing metacells. radius Numeric value specifying radius (units spatial coordinates) within neighboring cells considered. bin Character string specifying column name metadata containing microregion identifier. bin.X Character string specifying column name metadata containing X spatial coordinates microregions. bin.Y Character string specifying column name metadata containing Y spatial coordinates microregions. min.cells.per.region Integer specifying minimum number cells required spatial microregion compute metacells. ncores Integer specifying number CPU cores use parallel processing (default: 1).","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/GetSpatialMetacells.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Construct Spatial Metacells from Single-Cell Spatial Data — GetSpatialMetacells","text":"matrix containing spatial metacell expression profiles, rows representing individual genes         columns representing metacells.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/GetSpatialMetacells.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Construct Spatial Metacells from Single-Cell Spatial Data — GetSpatialMetacells","text":"","code":"library(data.table) library(Seurat) library(SpatialEcoTyper) library(googledrive) drive_deauth() # no Google sign-in is required drive_download(as_id(\"1CgUOQKrWY_TG61o5aw7J9LZzE20D6NuI\"),                     \"HumanMelanomaPatient1_subset_scmeta.tsv\", overwrite = TRUE) #> File downloaded: #> • HumanMelanomaPatient1_subset_scmeta.tsv #>    #> Saved locally as: #> • HumanMelanomaPatient1_subset_scmeta.tsv drive_download(as_id(\"1CoQmU3u8MoVC8RbLUvTDQmOuJJ703HHB\"),               \"HumanMelanomaPatient1_subset_counts.tsv.gz\", overwrite = TRUE) #> File downloaded: #> • HumanMelanomaPatient1_subset_counts.tsv.gz #>    #> Saved locally as: #> • HumanMelanomaPatient1_subset_counts.tsv.gz scdata <- fread(\"HumanMelanomaPatient1_subset_counts.tsv.gz\",                 sep = \"\\t\",header = TRUE, data.table = FALSE) rownames(scdata) <- scdata[, 1] scdata <- as.matrix(scdata[, -1]) normdata = NormalizeData(scdata) scmeta <- read.table(\"HumanMelanomaPatient1_subset_scmeta.tsv\",                       sep = \"\\t\",header = TRUE, row.names = 1)  # Construct spatial metacells from single-cell spatial data metacells <- GetSpatialMetacells(normdata = normdata, metadata = scmeta,                                  X = \"X\", Y = \"Y\", CellType = \"CellType\") head(metacells) #> 6 x 7711 Matrix of class \"dgeMatrix\" #>          X66_Y-91..B X62_Y-91..B X64_Y-92..B X63_Y-92..B X61_Y-92..B #> PDK4               0    0.000000   0.0000000   0.0000000    0.000000 #> TNFRSF17           0    0.000000   1.6049446   0.9508847    0.000000 #> ICAM3              0    3.056593   2.5135272   3.2732424    2.698584 #> FAP                0    0.000000   0.0000000   0.0000000    0.000000 #> GZMB               0    0.000000   0.8442368   0.0000000    0.000000 #> TSC2               0    0.000000   0.0000000   0.9333217    0.000000 #>          X62_Y-92..B X64_Y-93..B X62_Y-93..B X61_Y-93..B X63_Y-93..B #> PDK4         0.00000    0.000000    0.000000    0.000000   0.0000000 #> TNFRSF17     0.00000    0.383744    0.000000    1.137039   0.5433627 #> ICAM3        2.42756    2.059535    2.478747    3.496900   3.0849468 #> FAP          0.00000    0.000000    0.000000    0.000000   0.0000000 #> GZMB         0.00000    1.672252    0.000000    0.000000   0.6873982 #> TSC2         0.00000    0.000000    0.000000    0.000000   0.5333267 #>          X62_Y-94..B X61_Y-96..B X65_Y-91..B X63_Y-91..B X64_Y-94..B #> PDK4        0.000000     0.00000    0.000000    0.000000    0.000000 #> TNFRSF17    0.000000     2.11725    1.425194    1.148879    0.000000 #> ICAM3       3.586821     2.14130    1.653918    5.075187    1.264459 #> FAP         0.000000     0.00000    0.000000    0.000000    0.000000 #> GZMB        0.000000     0.00000    0.000000    0.000000    1.264459 #> TSC2        0.000000     0.00000    0.000000    0.000000    0.000000 #>          X56_Y-91..B X58_Y-92..B X59_Y-92..B X58_Y-93..B X54_Y-93..B #> PDK4               0      0.0000    0.000000           0           0 #> TNFRSF17           0      0.0000    0.000000           0           0 #> ICAM3              0      2.2414    3.588517           0           0 #> FAP                0      0.0000    0.000000           0           0 #> GZMB               0      0.0000    0.000000           0           0 #> TSC2               0      0.0000    0.000000           0           0 #>          X58_Y-94..B X56_Y-95..B X59_Y-95..B X57_Y-96..B X56_Y-96..B #> PDK4        0.000000   0.0000000           0     0.00000    0.000000 #> TNFRSF17    0.000000   2.6163040           0     1.29846    1.817844 #> ICAM3       4.848761   2.0284363           0     4.24806    3.856029 #> FAP         0.000000   0.0000000           0     0.00000    0.000000 #> GZMB        0.000000   0.6726485           0     0.00000    0.000000 #> TSC2        0.000000   0.0000000           0     0.00000    0.000000 #>          X59_Y-97..B X57_Y-97..B X56_Y-97..B X55_Y-95..B X76_Y-102..B #> PDK4        0.000000    0.000000    0.000000    0.000000     0.000000 #> TNFRSF17    0.000000    1.056955    0.000000    4.567223     2.225693 #> ICAM3       4.706922    1.155021    3.326435    2.209223     2.376547 #> FAP         0.000000    0.000000    0.000000    0.000000     0.000000 #> GZMB        0.000000    0.000000    0.000000    2.354270     0.000000 #> TSC2        0.000000    0.000000    0.000000    0.000000     0.000000 #>          X77_Y-102..B X75_Y-90..B X75_Y-88..B X42_Y-78..B X76_Y-73..B #> PDK4         0.000000    0.000000    0.000000    0.000000    0.000000 #> TNFRSF17     2.225693    0.000000    0.000000    4.163422    3.491864 #> ICAM3        2.376547    4.900324    5.476862    5.537982    4.169673 #> FAP          0.000000    0.000000    0.000000    0.000000    0.000000 #> GZMB         0.000000    0.000000    0.000000    0.000000    0.000000 #> TSC2         0.000000    0.000000    0.000000    0.000000    0.000000 #>          X74_Y-73..B X73_Y-74..B X73_Y-75..B X75_Y-78..B X73_Y-73..B #> PDK4        0.000000    0.000000     0.00000    0.000000    0.000000 #> TNFRSF17    1.215350    0.000000     0.00000    2.058892    1.620467 #> ICAM3       2.579869    3.150018     2.82084    1.720393    5.175989 #> FAP         0.000000    0.000000     0.00000    0.000000    0.000000 #> GZMB        0.000000    0.000000     0.00000    0.000000    0.000000 #> TSC2        0.000000    0.000000     0.00000    0.000000    0.000000 #>          X73_Y-76..B X62_Y-70..B X63_Y-70..B X67_Y-75..B X72_Y-74..B #> PDK4        0.000000    0.000000    0.000000    0.000000    0.000000 #> TNFRSF17    0.000000    4.861401    2.430701    0.000000    2.405894 #> ICAM3       5.727247    4.459799    4.405866    2.146131    2.365282 #> FAP         0.000000    0.000000    0.000000    0.000000    0.000000 #> GZMB        0.000000    3.778150    1.889075    0.000000    0.000000 #> TSC2        0.000000    0.000000    0.000000    0.000000    0.000000 #>          X72_Y-75..B X68_Y-75..B X71_Y-75..B X69_Y-75..B X72_Y-76..B #> PDK4       0.0000000    0.000000    0.000000    0.000000   0.0000000 #> TNFRSF17   0.9891199    0.000000    0.000000    0.000000   1.1521029 #> ICAM3      2.3473298    4.505335    2.119072    4.743091   4.1962180 #> FAP        0.0000000    0.000000    0.000000    0.000000   0.0000000 #> GZMB       0.3010424    0.000000    1.053648    0.000000   0.5268242 #> TSC2       0.0000000    0.000000    0.000000    0.000000   0.0000000 #>          X68_Y-76..B X70_Y-76..B X69_Y-77..B X68_Y-77..B X70_Y-77..B #> PDK4               0   0.0000000    0.000000     0.00000           0 #> TNFRSF17           0   0.7068714    0.635359     0.00000           0 #> ICAM3              0   2.2229375    2.970187     1.81018           0 #> FAP                0   0.0000000    0.000000     0.00000           0 #> GZMB               0   0.0000000    0.000000     0.00000           0 #> TSC2               0   0.0000000    0.000000     0.00000           0 #>          X72_Y-77..B X71_Y-78..B X70_Y-78..B X71_Y-79..B X70_Y-79..B #> PDK4        0.000000   0.0000000    0.000000    0.000000    0.000000 #> TNFRSF17    0.000000   0.5914898    1.171932    0.000000    0.000000 #> ICAM3       4.645283   1.6259953    1.412128    3.682414    4.156191 #> FAP         0.000000   0.0000000    0.000000    0.000000    0.000000 #> GZMB        0.000000   0.4806457    0.000000    0.000000    0.000000 #> TSC2        0.000000   0.0000000    0.000000    0.000000    0.000000 #>          X67_Y-74..B X68_Y-74..B X67_Y-76..B X71_Y-76..B X71_Y-77..B #> PDK4               0    0.000000    0.000000    0.000000    0.000000 #> TNFRSF17           0    0.000000    0.000000    1.432264    1.064682 #> ICAM3              0    1.847129    1.739192    1.795429    2.002926 #> FAP                0    0.000000    0.000000    0.000000    0.000000 #> GZMB               0    0.000000    0.000000    0.000000    0.000000 #> TSC2               0    0.000000    0.000000    0.000000    0.000000 #>          X54_Y-78..B X54_Y-79..B X51_Y-73..B X52_Y-73..B X49_Y-78..B #> PDK4        0.000000    0.000000    0.000000    0.000000    0.000000 #> TNFRSF17    0.000000    1.361292    0.000000    1.470127    1.262179 #> ICAM3       1.194038    2.452523    4.756657    3.204808    2.534343 #> FAP         0.000000    0.000000    0.000000    0.000000    0.000000 #> GZMB        0.000000    0.634420    0.000000    0.000000    0.000000 #> TSC2        0.000000    0.000000    0.000000    0.000000    0.000000 #>          X48_Y-78..B X49_Y-79..B X53_Y-75..B X53_Y-76..B X50_Y-79..B #> PDK4        0.000000    0.000000    0.000000    0.000000    0.000000 #> TNFRSF17    0.000000    0.000000    4.403978    4.459799    1.027227 #> ICAM3       2.481897    2.890517    4.403978    4.459799    2.353053 #> FAP         0.000000    0.000000    0.000000    0.000000    0.000000 #> GZMB        0.000000    0.000000    2.229899    4.459799    0.000000 #> TSC2        0.000000    0.000000    0.000000    0.000000    0.000000 #>          X53_Y-79..B X47_Y-92..B X44_Y-92..B X46_Y-93..B X44_Y-91..B #> PDK4       0.0000000           0    0.000000    0.000000           0 #> TNFRSF17   0.5502978           0    0.000000    0.000000           0 #> ICAM3      3.0141224           0    2.238421    5.057837           0 #> FAP        0.0000000           0    0.000000    0.000000           0 #> GZMB       0.0000000           0    0.000000    0.000000           0 #> TSC2       0.0000000           0    0.000000    5.057837           0 #>          X45_Y-92..B X47_Y-66..B X48_Y-66..B X54_Y-64..B X52_Y-65..B #> PDK4        0.000000    0.000000    0.000000      0.0000   0.0000000 #> TNFRSF17    0.000000    0.000000    0.000000      0.0000   0.9805178 #> ICAM3       2.225693    5.364882    2.322641      1.4115   3.5523383 #> FAP         0.000000    0.000000    0.000000      0.0000   0.0000000 #> GZMB        0.000000    0.000000    0.000000      0.0000   0.0000000 #> TSC2        0.000000    0.000000    0.000000      0.0000   0.0000000 #>          X51_Y-66..B X48_Y-67..B X51_Y-67..B X50_Y-64..B X54_Y-65..B #> PDK4       0.0000000    0.000000      0.0000    0.000000     0.00000 #> TNFRSF17   0.8869554    0.000000      2.1335    0.000000     0.00000 #> ICAM3      0.9710122    3.190812      2.1335    2.166602     2.11725 #> FAP        0.0000000    0.000000      0.0000    0.000000     0.00000 #> GZMB       1.2288870    0.000000      0.0000    0.000000     0.00000 #> TSC2       0.0000000    0.000000      0.0000    0.000000     0.00000 #>          X53_Y-65..B X49_Y-65..B X49_Y-66..B X52_Y-66..B X50_Y-66..B #> PDK4               0    0.000000    0.000000    0.000000    0.000000 #> TNFRSF17           0    1.151317    1.151317    0.000000    0.000000 #> ICAM3              0    0.000000    0.000000    3.345598    2.166602 #> FAP                0    0.000000    0.000000    0.000000    0.000000 #> GZMB               0    0.000000    0.000000    0.000000    3.072218 #> TSC2               0    0.000000    0.000000    0.000000    0.000000 #>          X49_Y-67..B X50_Y-67..B X36_Y-83..B X37_Y-84..B X42_Y-85..B #> PDK4        0.000000    0.000000           0    0.000000   0.0000000 #> TNFRSF17    0.000000    0.000000           0    1.899630   0.6837525 #> ICAM3       3.190812    3.665744           0    1.899630   2.4151935 #> FAP         0.000000    0.000000           0    0.000000   0.0000000 #> GZMB        0.000000    0.000000           0    1.812122   0.2174079 #> TSC2        0.000000    0.000000           0    0.000000   0.0000000 #>          X44_Y-73..B X47_Y-74..B X44_Y-74..B X45_Y-74..B X46_Y-75..B #> PDK4               0           0   0.0000000    0.000000    0.000000 #> TNFRSF17           0           0   0.4543282    0.555290    1.191139 #> ICAM3              0           0   2.1856303    2.161786    2.252606 #> FAP                0           0   0.0000000    0.000000    0.000000 #> GZMB               0           0   0.0000000    0.000000    0.000000 #> TSC2               0           0   0.0000000    0.000000    0.000000 #>          X44_Y-75..B X45_Y-75..B X44_Y-76..B X42_Y-76..B X45_Y-76..B #> PDK4       0.0000000    0.000000    0.000000           0    0.000000 #> TNFRSF17   0.9697523    0.000000    0.000000           0    0.000000 #> ICAM3      1.8213317    2.262653    1.584485           0    3.569047 #> FAP        0.0000000    0.000000    0.000000           0    0.000000 #> GZMB       0.0000000    0.000000    0.000000           0    0.000000 #> TSC2       0.0000000    1.921466    0.000000           0    0.000000 #>          X47_Y-76..B X43_Y-76..B X46_Y-76..B X46_Y-77..B X45_Y-77..B #> PDK4        0.000000   0.0000000   0.0000000   0.0000000    0.000000 #> TNFRSF17    0.000000   0.0000000   0.2104024   0.6125659    1.149039 #> ICAM3       4.346490   1.8942054   2.7932473   3.8361366    3.517611 #> FAP         0.000000   0.0000000   0.0000000   0.0000000    0.000000 #> GZMB        2.076629   0.3997759   0.4153259   0.2671964    0.000000 #> TSC2        0.000000   0.0000000   0.2066379   0.2283413    0.000000 #>          X46_Y-78..B X45_Y-78..B X45_Y-79..B X44_Y-79..B X47_Y-79..B #> PDK4       0.0000000   0.0000000   0.0000000           0   0.0000000 #> TNFRSF17   0.6647316   0.0000000   0.4652812           0   0.6690602 #> ICAM3      1.8095057   2.3311942   3.6685605           0   3.1167736 #> FAP        0.0000000   0.0000000   0.0000000           0   0.0000000 #> GZMB       0.4372764   0.5938873   0.0000000           0   0.0000000 #> TSC2       0.0000000   0.0000000   0.0000000           0   0.3960912 #>          X46_Y-79..B X47_Y-78..B X75_Y-79..B X75_Y-80..B X77_Y-82..B #> PDK4       0.0000000   0.0000000    0.000000    0.000000    0.000000 #> TNFRSF17   0.2491555   0.6433513    0.000000    1.573163    4.836282 #> ICAM3      2.4966915   2.6336547    4.529834    1.802723    0.000000 #> FAP        0.0000000   0.0000000    0.000000    0.000000    0.000000 #> GZMB       0.6265417   0.0000000    0.000000    0.000000    0.000000 #> TSC2       0.2075520   0.0000000    0.000000    0.000000    0.000000 #>          X75_Y-81..B X74_Y-67..B X73_Y-67..B X74_Y-68..B X75_Y-68..B #> PDK4               0   0.0000000    0.000000   0.0000000   0.0000000 #> TNFRSF17           0   0.0000000    0.000000   0.0000000   0.3469518 #> ICAM3              0   3.3201526    3.607293   3.2840292   1.2847042 #> FAP                0   0.0000000    0.000000   0.0000000   0.0000000 #> GZMB               0   0.4019965    0.000000   0.4385417   0.3999805 #> TSC2               0   0.0000000    0.000000   0.4016769   0.0000000 #>          X75_Y-69..B X74_Y-69..B X76_Y-69..B X76_Y-70..B X73_Y-70..B #> PDK4       0.0000000   0.0000000    0.000000           0   0.0000000 #> TNFRSF17   0.3469518   1.0236658    0.000000           0   0.6312631 #> ICAM3      2.9231439   3.7946510    1.588185           0   3.4717022 #> FAP        0.0000000   0.0000000    0.000000           0   0.0000000 #> GZMB       0.7875139   0.5167112    0.000000           0   0.5885675 #> TSC2       0.0000000   0.4909384    0.000000           0   0.0000000 #>          X74_Y-70..B X73_Y-71..B X74_Y-71..B X74_Y-72..B X73_Y-72..B #> PDK4       0.0000000   0.0000000   0.0000000   0.0000000    0.000000 #> TNFRSF17   0.4557445   0.6873982   0.3207858   0.0000000    0.000000 #> ICAM3      3.2332347   4.2071137   3.2907634   2.3859686    4.118722 #> FAP        0.0000000   0.0000000   0.0000000   0.0000000    0.000000 #> GZMB       0.9822268   0.6179731   0.8854903   0.3034288    0.000000 #> TSC2       0.0000000   0.0000000   0.0000000   0.0000000    0.000000 #>          X73_Y-68..B X73_Y-69..B X48_Y-79..B X46_Y-80..B X45_Y-80..B #> PDK4               0    0.000000    0.000000   0.0000000   0.0000000 #> TNFRSF17           0    0.000000    0.000000   0.0000000   0.2260400 #> ICAM3              0    2.470424    2.170326   3.2481627   3.4603199 #> FAP                0    0.000000    0.000000   0.0000000   0.0000000 #> GZMB               0    0.000000    0.000000   0.2284554   0.2221523 #> TSC2               0    0.000000    0.000000   0.2184758   0.2130847 #>          X43_Y-80..B X44_Y-80..B X46_Y-81..B X45_Y-81..B X44_Y-81..B #> PDK4        0.000000   0.0000000    0.000000   0.0000000   0.0000000 #> TNFRSF17    0.000000   0.8083552    0.000000   0.4297029   0.9307104 #> ICAM3       1.960745   1.4005323    4.142261   2.8854139   2.7811556 #> FAP         0.000000   0.0000000    0.000000   0.0000000   0.0000000 #> GZMB        0.000000   0.0000000    1.253864   0.0000000   0.0000000 #> TSC2        0.000000   0.0000000    0.000000   0.0000000   0.0000000 #>          X43_Y-81..B X43_Y-82..B X44_Y-82..B X44_Y-83..B X43_Y-83..B #> PDK4       0.0000000   0.0000000   0.0000000    0.000000   0.0000000 #> TNFRSF17   0.5199608   0.6756255   0.6820723    0.000000   1.1535714 #> ICAM3      2.3077972   2.1366305   2.7427978    4.452312   2.8168004 #> FAP        0.0000000   0.0000000   0.0000000    0.000000   0.0000000 #> GZMB       0.0000000   0.0000000   0.0000000    0.000000   0.6531461 #> TSC2       0.0000000   0.0000000   0.0000000    0.000000   0.0000000 #>          X43_Y-84..B X42_Y-84..B X44_Y-84..B X43_Y-85..B X44_Y-85..B #> PDK4       0.0000000   0.0000000           0   0.0000000   0.0000000 #> TNFRSF17   0.4147101   0.4865075           0   0.0000000   0.0000000 #> ICAM3      3.3261431   2.6702620           0   2.0133817   2.6620434 #> FAP        0.0000000   0.0000000           0   0.0000000   0.0000000 #> GZMB       0.0000000   0.0000000           0   0.2174079   0.6510636 #> TSC2       0.0000000   0.0000000           0   0.0000000   0.0000000 #>          X51_Y-91..B X53_Y-92..B X71_Y-82..B X71_Y-83..B X67_Y-84..B #> PDK4        0.000000           0    0.000000    0.000000    0.000000 #> TNFRSF17    0.000000           0    2.283413    0.000000    0.000000 #> ICAM3       2.120614           0    0.000000    1.429282    2.560989 #> FAP         0.000000           0    0.000000    0.000000    0.000000 #> GZMB        0.000000           0    0.000000    0.000000    0.000000 #> TSC2        0.000000           0    2.283413    0.000000    0.000000 #>          X70_Y-84..B X68_Y-84..B X69_Y-84..B X69_Y-85..B X71_Y-80..B #> PDK4        0.000000    0.000000    0.000000   0.0000000           0 #> TNFRSF17    1.265673    0.000000    0.000000   0.0000000           0 #> ICAM3       3.927594    3.655262    2.975360   3.1011481           0 #> FAP         0.000000    0.000000    0.000000   0.0000000           0 #> GZMB        0.000000    0.000000    1.124994   0.4195564           0 #> TSC2        0.000000    0.000000    0.000000   0.0000000           0 #>          X71_Y-81..B X72_Y-83..B X70_Y-83..B X70_Y-85..B X68_Y-85..B #> PDK4        0.000000    0.000000    0.000000   0.0000000   0.0000000 #> TNFRSF17    2.283413    0.000000    1.784959   0.6608008   0.0000000 #> ICAM3       0.000000    2.491555    2.993083   3.3247117   2.3770512 #> FAP         0.000000    0.000000    0.000000   0.0000000   0.0000000 #> GZMB        0.000000    0.000000    0.000000   0.6173469   0.7691868 #> TSC2        2.283413    0.000000    0.000000   0.0000000   0.0000000 #>          X50_Y-69..B X49_Y-69..B X52_Y-72..B X51_Y-68..B X49_Y-68..B #> PDK4       0.0000000   0.0000000           0    0.000000           0 #> TNFRSF17   0.9152592   0.0000000           0    0.000000           0 #> ICAM3      1.0115674   2.3390514           0    3.122069           0 #> FAP        0.0000000   0.0000000           0    0.000000           0 #> GZMB       0.0000000   0.7504965           0    0.000000           0 #> TSC2       0.0000000   0.7377629           0    0.000000           0 #>          X51_Y-69..B X52_Y-71..B X65_Y-65..B X57_Y-80..B X56_Y-81..B #> PDK4        0.000000           0    0.000000           0    0.000000 #> TNFRSF17    0.000000           0    4.676402           0    0.000000 #> ICAM3       2.031452           0    0.000000           0    3.008576 #> FAP         0.000000           0    0.000000           0    0.000000 #> GZMB        0.000000           0    0.000000           0    0.000000 #> TSC2        0.000000           0    0.000000           0    0.000000 #>          X59_Y-81..B X57_Y-82..B X58_Y-81..B X58_Y-82..B X59_Y-84..B #> PDK4               0    0.000000    0.000000    0.000000           0 #> TNFRSF17           0    2.595287    0.000000    0.000000           0 #> ICAM3              0    2.225693    4.825431    4.825431           0 #> FAP                0    0.000000    0.000000    0.000000           0 #> GZMB               0    0.000000    0.000000    0.000000           0 #> TSC2               0    0.000000    0.000000    0.000000           0 #>          X56_Y-79..B X56_Y-80..B X55_Y-80..B X55_Y-81..B X56_Y-82..B #> PDK4        0.000000           0    0.000000           0    0.000000 #> TNFRSF17    0.000000           0    0.000000           0    1.730191 #> ICAM3       2.552774           0    5.121978           0    1.675755 #> FAP         0.000000           0    0.000000           0    0.000000 #> GZMB        0.000000           0    0.000000           0    0.000000 #> TSC2        0.000000           0    0.000000           0    0.000000 #>          X57_Y-83..B X64_Y-84..B X63_Y-84..B X65_Y-85..B X63_Y-85..B #> PDK4        0.000000    0.000000   0.0000000   0.0000000   0.0000000 #> TNFRSF17    2.595287    0.000000   0.8773159   0.8703865   1.1782220 #> ICAM3       2.312536    2.677175   1.8470682   3.7304454   2.8149688 #> FAP         0.000000    0.000000   0.0000000   0.0000000   0.0000000 #> GZMB        0.000000    0.000000   1.0146972   1.1190904   0.7247837 #> TSC2        0.000000    0.000000   0.0000000   0.0000000   0.0000000 #>          X61_Y-85..B X66_Y-84..B X36_Y-93..B X36_Y-92..B X34_Y-94..B #> PDK4        0.000000    0.000000    0.000000    0.000000           0 #> TNFRSF17    1.132458    0.000000    1.901769    1.541691           0 #> ICAM3       2.473679    5.121978    4.648633    1.325662           0 #> FAP         0.000000    0.000000    0.000000    0.000000           0 #> GZMB        0.000000    0.000000    0.000000    0.000000           0 #> TSC2        1.169100    0.000000    0.000000    0.000000           0 #>          X35_Y-97..B X43_Y-86..B X42_Y-86..B X44_Y-86..B X43_Y-87..B #> PDK4               0   0.0000000    0.000000   0.0000000   0.0000000 #> TNFRSF17           0   0.2269476    0.225149   0.9525449   0.6184871 #> ICAM3              0   3.6483110    1.918486   3.3324674   2.9738375 #> FAP                0   0.0000000    0.000000   0.0000000   0.0000000 #> GZMB               0   0.0000000    0.000000   0.0000000   0.0000000 #> TSC2               0   0.0000000    0.000000   0.0000000   0.0000000 #>          X44_Y-87..B X42_Y-87..B X45_Y-87..B X42_Y-88..B X44_Y-88..B #> PDK4       0.0000000   0.0000000    0.000000    0.000000   0.0000000 #> TNFRSF17   0.6323202   0.2185514    0.000000    0.620909   0.4240316 #> ICAM3      3.5784903   3.0873261    1.555306    3.613346   3.9456665 #> FAP        0.0000000   0.0000000    0.000000    0.000000   0.0000000 #> GZMB       0.0000000   0.1949055    0.000000    0.000000   0.1970840 #> TSC2       0.0000000   0.0000000    1.327379    0.000000   0.0000000 #>          X43_Y-88..B X45_Y-88..B X43_Y-89..B X42_Y-89..B X46_Y-89..B #> PDK4       0.0000000    0.000000   0.0000000   0.0000000   0.0000000 #> TNFRSF17   0.5452494    0.000000   0.6935526   0.2042816   0.7675449 #> ICAM3      3.2789595    1.316071   3.2069784   3.3444017   3.9839161 #> FAP        0.0000000    0.000000   0.0000000   0.0000000   0.0000000 #> GZMB       0.0000000    0.000000   0.0000000   0.2463577   0.7675449 #> TSC2       0.0000000    0.000000   0.1536776   0.0000000   0.0000000 #>          X44_Y-89..B X47_Y-89..B X45_Y-89..B X43_Y-90..B X48_Y-90..B #> PDK4        0.000000    0.000000   0.0000000   0.0000000    0.000000 #> TNFRSF17    1.036512    1.383680   0.4605269   0.2348855    0.000000 #> ICAM3       1.828444    2.983602   2.1614393   3.2628638    2.984646 #> FAP         0.000000    0.000000   0.0000000   0.0000000    0.000000 #> GZMB        0.000000    0.000000   0.4605269   0.0000000    0.000000 #> TSC2        0.000000    0.000000   0.0000000   0.0000000    0.000000 #>          X42_Y-90..B X44_Y-90..B X47_Y-90..B X45_Y-90..B X46_Y-87..B #> PDK4       0.0000000   0.0000000    0.000000    0.000000           0 #> TNFRSF17   0.4603805   0.8529633    2.075520    0.000000           0 #> ICAM3      2.8731964   2.4976425    4.475403    3.055309           0 #> FAP        0.0000000   0.0000000    0.000000    0.000000           0 #> GZMB       0.2307560   0.2094335    0.000000    0.000000           0 #> TSC2       0.0000000   0.0000000    0.000000    0.000000           0 #>          X46_Y-88..B X47_Y-88..B X48_Y-89..B X41_Y-89..B X43_Y-91..B #> PDK4        0.000000           0   0.0000000           0    0.000000 #> TNFRSF17    0.000000           0   0.7350635           0    2.293638 #> ICAM3       2.237996           0   3.1992382           0    3.851602 #> FAP         0.000000           0   0.0000000           0    0.000000 #> GZMB        0.000000           0   0.0000000           0    0.000000 #> TSC2        0.000000           0   0.0000000           0    0.000000 #>          X55_Y-79..B X53_Y-80..B X49_Y-80..B X52_Y-81..B X51_Y-82..B #> PDK4        0.000000    0.000000    0.000000           0    0.000000 #> TNFRSF17    0.000000    0.000000    0.000000           0    0.000000 #> ICAM3       5.242795    2.964811    4.573885           0    4.900324 #> FAP         0.000000    0.000000    0.000000           0    0.000000 #> GZMB        0.000000    0.000000    0.000000           0    0.000000 #> TSC2        0.000000    0.000000    0.000000           0    0.000000 #>          X50_Y-82..B X51_Y-83..B X52_Y-83..B X51_Y-84..B X53_Y-85..B #> PDK4        0.000000    0.000000    0.000000     0.00000    0.000000 #> TNFRSF17    3.780260    3.786538    0.000000     0.00000    2.201191 #> ICAM3       2.234142    4.468283    2.283413     2.03995    4.002774 #> FAP         0.000000    0.000000    0.000000     0.00000    0.000000 #> GZMB        0.000000    0.000000    0.000000     0.00000    0.000000 #> TSC2        0.000000    0.000000    0.000000     0.00000    0.000000 #>          X52_Y-80..B X54_Y-82..B X67_Y-96..B X68_Y-96..B X76_Y-97..B #> PDK4        0.000000           0    0.000000    0.000000    0.000000 #> TNFRSF17    0.000000           0    4.378773    0.000000    0.000000 #> ICAM3       1.500993           0    4.378773    4.940848    4.451387 #> FAP         0.000000           0    0.000000    0.000000    0.000000 #> GZMB        0.000000           0    0.000000    0.000000    0.000000 #> TSC2        0.000000           0    0.000000    0.000000    0.000000 #>          X77_Y-94..B X74_Y-96..B X45_Y-69..B X46_Y-69..B X47_Y-70..B #> PDK4        0.000000    0.000000    0.000000    0.000000    0.000000 #> TNFRSF17    0.000000    0.000000    0.000000    0.000000    0.000000 #> ICAM3       4.836282    4.163422    4.275582    5.305734    1.538374 #> FAP         0.000000    0.000000    0.000000    0.000000    0.000000 #> GZMB        0.000000    0.000000    0.000000    0.000000    0.000000 #> TSC2        0.000000    0.000000    0.000000    0.000000    0.000000 #>          X46_Y-70..B X48_Y-70..B X47_Y-71..B X45_Y-72..B X47_Y-73..B #> PDK4               0     0.00000    0.000000           0      0.0000 #> TNFRSF17           0     0.00000    0.000000           0      0.0000 #> ICAM3              0     3.18383    3.454502           0      2.0371 #> FAP                0     0.00000    0.000000           0      0.0000 #> GZMB               0     0.00000    0.000000           0      0.0000 #> TSC2               0     0.00000    0.000000           0      0.0000 #>          X46_Y-67..B X46_Y-68..B X47_Y-69..B X46_Y-71..B X73_Y-65..B #> PDK4        0.000000    0.000000    0.000000    0.000000     0.00000 #> TNFRSF17    1.088931    1.451907    0.000000    0.000000     0.00000 #> ICAM3       2.349539    3.132718    5.075529    3.454502     2.50247 #> FAP         0.000000    0.000000    0.000000    0.000000     0.00000 #> GZMB        0.000000    0.000000    0.000000    0.000000     0.00000 #> TSC2        0.000000    0.000000    0.000000    0.000000     0.00000 #>          X73_Y-66..B X76_Y-66..B X41_Y-88..B X36_Y-88..B X30_Y-103..B #> PDK4        0.000000     0.00000    0.000000           0     0.000000 #> TNFRSF17    0.000000     0.00000    1.286991           0     0.000000 #> ICAM3       3.433638     4.70854    0.000000           0     4.615121 #> FAP         0.000000     0.00000    0.000000           0     0.000000 #> GZMB        0.000000     0.00000    0.000000           0     0.000000 #> TSC2        0.000000     0.00000    0.000000           0     0.000000 #>          X31_Y-103..B X32_Y-103..B X28_Y-101..B X27_Y-101..B X27_Y-102..B #> PDK4         0.000000     0.000000    0.0000000    0.0000000      0.00000 #> TNFRSF17     0.000000     4.046200    0.0000000    0.0000000      0.00000 #> ICAM3        2.382278     5.133085    3.8252390    3.8252390      5.04754 #> FAP          0.000000     0.000000    0.0000000    0.0000000      0.00000 #> GZMB         0.000000     0.000000    0.9373996    0.9373996      0.00000 #> TSC2         0.000000     0.000000    0.0000000    0.0000000      0.00000 #>          X30_Y-102..B X61_Y-100..B X62_Y-100..B X64_Y-100..B X64_Y-101..B #> PDK4                0     0.000000     0.000000     0.000000    0.0000000 #> TNFRSF17            0     2.197225     0.000000     0.000000    0.8742058 #> ICAM3               0     4.733968     4.576296     3.689523    2.8111273 #> FAP                 0     0.000000     0.000000     0.000000    0.0000000 #> GZMB                0     3.087934     0.000000     0.000000    0.0000000 #> TSC2                0     0.000000     0.000000     0.000000    0.0000000 #>          X63_Y-101..B X64_Y-102..B X64_Y-104..B X65_Y-100..B X65_Y-101..B #> PDK4                0     0.000000     0.000000     0.000000     0.000000 #> TNFRSF17            0     4.655546     0.000000     0.000000     1.092757 #> ICAM3               0     0.000000     2.822176     5.035548     3.610531 #> FAP                 0     0.000000     0.000000     0.000000     0.000000 #> GZMB                0     0.000000     0.000000     0.000000     0.000000 #> TSC2                0     0.000000     0.000000     0.000000     0.000000 #>          X60_Y-102..B X66_Y-102..B X65_Y-102..B X70_Y-86..B X69_Y-86..B #> PDK4         0.000000            0     0.000000   0.0000000    0.000000 #> TNFRSF17     0.000000            0     4.655546   0.5063828    1.067448 #> ICAM3        5.313305            0     4.655546   2.3459965    3.326446 #> FAP          0.000000            0     0.000000   0.0000000    0.000000 #> GZMB         0.000000            0     0.000000   0.0000000    0.000000 #> TSC2         0.000000            0     0.000000   0.4927530    0.000000 #>          X68_Y-86..B X67_Y-86..B X69_Y-87..B X68_Y-87..B X67_Y-87..B #> PDK4        0.000000    0.000000   0.0000000   0.0000000   0.0000000 #> TNFRSF17    1.128071    0.000000   0.0000000   0.4186608   0.9529113 #> ICAM3       3.260184    4.620157   1.8693242   1.2612400   0.0000000 #> FAP         0.000000    0.000000   0.0000000   0.0000000   0.0000000 #> GZMB        0.000000    0.000000   0.0000000   0.0000000   0.0000000 #> TSC2        0.000000    0.000000   0.5543472   0.0000000   0.0000000 #>          X68_Y-88..B X69_Y-89..B X70_Y-87..B X69_Y-88..B X67_Y-88..B #> PDK4               0    0.000000    0.000000           0           0 #> TNFRSF17           0    0.000000    0.000000           0           0 #> ICAM3              0    3.961696    0.000000           0           0 #> FAP                0    0.000000    0.000000           0           0 #> GZMB               0    0.000000    0.000000           0           0 #> TSC2               0    0.000000    2.217389           0           0 #>          X68_Y-90..B X26_Y-107..B X72_Y-100..B X71_Y-101..B X69_Y-104..B #> PDK4        0.000000     0.000000     0.000000     0.000000     0.000000 #> TNFRSF17    0.000000     2.302635     0.000000     2.498805     0.000000 #> ICAM3       5.089387     1.893269     4.635125     3.049536     2.343499 #> FAP         0.000000     0.000000     0.000000     0.000000     0.000000 #> GZMB        0.000000     1.893269     0.000000     0.000000     0.000000 #> TSC2        0.000000     0.000000     0.000000     0.000000     0.000000 #>          X70_Y-104..B X67_Y-104..B X70_Y-105..B X68_Y-106..B X70_Y-106..B #> PDK4                0            0            0     0.000000            0 #> TNFRSF17            0            0            0     0.000000            0 #> ICAM3               0            0            0     0.000000            0 #> FAP                 0            0            0     0.000000            0 #> GZMB                0            0            0     4.169673            0 #> TSC2                0            0            0     0.000000            0 #>          X63_Y-105..B X66_Y-106..B X52_Y-105..B X31_Y-104..B X33_Y-104..B #> PDK4                0            0            0            0     0.000000 #> TNFRSF17            0            0            0            0     0.000000 #> ICAM3               0            0            0            0     5.350863 #> FAP                 0            0            0            0     0.000000 #> GZMB                0            0            0            0     0.000000 #> TSC2                0            0            0            0     0.000000 #>          X35_Y-104..B X56_Y-98..B X58_Y-98..B X56_Y-99..B X59_Y-99..B #> PDK4                0   0.0000000    0.000000     0.00000    0.000000 #> TNFRSF17            0   0.7298883    0.000000     1.21648    0.000000 #> ICAM3               0   2.6164556    3.532434     1.21648    4.964721 #> FAP                 0   0.0000000    0.000000     0.00000    0.000000 #> GZMB                0   0.0000000    0.000000     0.00000    0.000000 #> TSC2                0   0.0000000    0.000000     0.00000    0.000000 #>          X56_Y-102..B X59_Y-98..B X58_Y-99..B X58_Y-100..B X42_Y-100..B #> PDK4         0.000000    0.000000    0.000000            0            0 #> TNFRSF17     4.913648    0.000000    0.000000            0            0 #> ICAM3        5.603116    3.532434    4.968821            0            0 #> FAP          0.000000    0.000000    0.000000            0            0 #> GZMB         0.000000    0.000000    0.000000            0            0 #> TSC2         0.000000    0.000000    0.000000            0            0 #>          X41_Y-101..B X41_Y-103..B X62_Y-85..B X64_Y-85..B X66_Y-86..B #> PDK4         0.000000            0           0   0.0000000   0.0000000 #> TNFRSF17     0.000000            0           0   1.3688179   0.0000000 #> ICAM3        2.646702            0           0   5.0343697   3.7583304 #> FAP          0.000000            0           0   0.0000000   0.0000000 #> GZMB         0.000000            0           0   0.9325753   0.0000000 #> TSC2         0.000000            0           0   0.0000000   0.9748411 #>          X63_Y-86..B X62_Y-86..B X65_Y-86..B X66_Y-87..B X65_Y-87..B #> PDK4        0.000000           0    0.000000   0.0000000    0.000000 #> TNFRSF17    0.000000           0    0.000000   0.6640457    0.000000 #> ICAM3       2.170326           0    2.948429   2.7503651    2.121432 #> FAP         0.000000           0    0.000000   0.0000000    0.000000 #> GZMB        0.000000           0    0.000000   0.0000000    0.000000 #> TSC2        0.000000           0    0.000000   0.0000000    0.000000 #>          X63_Y-87..B X62_Y-89..B X63_Y-89..B X64_Y-89..B X63_Y-90..B #> PDK4        0.000000    0.000000           0           0   0.0000000 #> TNFRSF17    4.182296    0.000000           0           0   0.9191032 #> ICAM3       0.000000    2.614978           0           0   4.8600150 #> FAP         0.000000    0.000000           0           0   0.0000000 #> GZMB        0.000000    1.509945           0           0   0.0000000 #> TSC2        0.000000    0.000000           0           0   0.0000000 #>          X65_Y-90..B X64_Y-90..B X66_Y-85..B X61_Y-86..B X62_Y-87..B #> PDK4        0.000000   0.0000000    0.000000    0.000000           0 #> TNFRSF17    3.054253   0.9774357    0.000000    0.000000           0 #> ICAM3       3.549709   2.0727552    2.437103    1.788294           0 #> FAP         0.000000   0.0000000    0.000000    0.000000           0 #> GZMB        0.000000   0.0000000    0.000000    0.000000           0 #> TSC2        0.000000   0.0000000    2.437103    1.558801           0 #>          X62_Y-90..B X64_Y-91..B X41_Y-92..B X40_Y-94..B X42_Y-96..B #> PDK4        0.000000    0.000000    0.000000    0.000000     0.00000 #> TNFRSF17    0.000000    0.000000    0.000000    0.000000     0.00000 #> ICAM3       4.529834    1.776734    3.364981    5.057837     4.69771 #> FAP         0.000000    0.000000    0.000000    0.000000     0.00000 #> GZMB        4.529834    0.000000    4.725012    0.000000     0.00000 #> TSC2        0.000000    0.000000    0.000000    0.000000     0.00000 #>          X42_Y-92..B X40_Y-105..B X41_Y-106..B X40_Y-107..B X40_Y-104..B #> PDK4        0.000000            0            0     0.000000     0.000000 #> TNFRSF17    0.000000            0            0     0.000000     0.000000 #> ICAM3       5.073486            0            0     2.247962     5.612132 #> FAP         0.000000            0            0     0.000000     0.000000 #> GZMB        0.000000            0            0     0.000000     4.520800 #> TSC2        0.000000            0            0     0.000000     0.000000 #>          X40_Y-106..B X52_Y-85..B X53_Y-86..B X49_Y-88..B X48_Y-88..B #> PDK4         0.000000    0.000000    0.000000           0    0.000000 #> TNFRSF17     0.000000    2.518675    4.402383           0    0.000000 #> ICAM3        2.997283    1.975818    4.402383           0    5.823279 #> FAP          0.000000    0.000000    0.000000           0    0.000000 #> GZMB         0.000000    0.000000    0.000000           0    0.000000 #> TSC2         0.000000    2.124001    0.000000           0    0.000000 #>          X54_Y-88..B X54_Y-89..B X50_Y-89..B X49_Y-90..B X50_Y-90..B #> PDK4        0.000000    0.000000           0    0.000000    0.000000 #> TNFRSF17    0.000000    0.000000           0    0.000000    0.000000 #> ICAM3       4.747414    4.858117           0    2.664418    2.165482 #> FAP         0.000000    0.000000           0    0.000000    0.000000 #> GZMB        0.000000    0.000000           0    0.000000    0.000000 #> TSC2        0.000000    0.000000           0    0.000000    0.000000 #>          X51_Y-90..B X49_Y-89..B X56_Y-87..B X56_Y-89..B X54_Y-90..B #> PDK4        0.000000    0.000000           0           0    0.000000 #> TNFRSF17    0.000000    4.611084           0           0    3.807837 #> ICAM3       2.288148    0.000000           0           0    3.807837 #> FAP         0.000000    0.000000           0           0    0.000000 #> GZMB        0.000000    0.000000           0           0    0.000000 #> TSC2        0.000000    0.000000           0           0    0.000000 #>          X55_Y-90..B X58_Y-91..B X57_Y-91..B X57_Y-88..B X55_Y-65..B #> PDK4               0    0.000000    0.000000           0    0.000000 #> TNFRSF17           0    0.000000    0.000000           0    0.000000 #> ICAM3              0    1.771102    5.313305           0    4.195087 #> FAP                0    0.000000    0.000000           0    0.000000 #> GZMB               0    0.000000    0.000000           0    0.000000 #> TSC2               0    0.000000    0.000000           0    0.000000 #>          X72_Y-64..B X72_Y-65..B X72_Y-66..B X49_Y-100..B X54_Y-103..B #> PDK4        0.000000    0.000000    0.000000      0.00000     0.000000 #> TNFRSF17    0.000000    0.000000    0.000000      0.00000     4.426577 #> ICAM3       4.544179    3.029452    1.665870      4.38658     0.000000 #> FAP         0.000000    0.000000    0.000000      0.00000     0.000000 #> GZMB        0.000000    0.000000    1.548428      0.00000     0.000000 #> TSC2        0.000000    0.000000    0.000000      0.00000     0.000000 #>          X44_Y-98..B X26_Y-96..CD4T X26_Y-97..CD4T X27_Y-98..CD4T #> PDK4               0       0.000000        0.00000      0.0000000 #> TNFRSF17           0       0.000000        0.00000      0.0000000 #> ICAM3              0       3.065884        3.94624      4.0085034 #> FAP                0       0.000000        0.00000      0.0000000 #> GZMB               0       0.000000        0.00000      0.0000000 #> TSC2               0       0.000000        0.00000      0.7731077 #>          X27_Y-96..CD4T X24_Y-96..CD4T X63_Y-91..CD4T X64_Y-91..CD4T #> PDK4                  0        0.00000       0.000000       0.000000 #> TNFRSF17              0        0.00000       0.000000       0.000000 #> ICAM3                 0        5.50086       3.539812       2.402751 #> FAP                   0        0.00000       0.000000       0.000000 #> GZMB                  0        0.00000       0.000000       0.714496 #> TSC2                  0        0.00000       0.000000       0.000000 #>          X62_Y-91..CD4T X64_Y-92..CD4T X61_Y-92..CD4T X62_Y-92..CD4T #> PDK4          0.0000000       0.000000      0.0000000      0.0000000 #> TNFRSF17      0.0000000       0.000000      0.0000000      0.0000000 #> ICAM3         3.2447005       2.960047      2.6487423      3.4995989 #> FAP           0.0000000       0.000000      0.0000000      0.0000000 #> GZMB          0.9125695       0.000000      0.0000000      0.2750825 #> TSC2          0.2735358       0.463333      0.2342835      0.0000000 #>          X63_Y-92..CD4T X62_Y-93..CD4T X65_Y-93..CD4T X61_Y-93..CD4T #> PDK4          0.0000000      0.0000000       0.000000        0.00000 #> TNFRSF17      0.0000000      0.0000000       0.000000        0.00000 #> ICAM3         3.2052549      3.6634460       1.420565        5.09924 #> FAP           0.0000000      0.0000000       0.000000        0.00000 #> GZMB          0.2590867      0.5188492       0.000000        0.00000 #> TSC2          0.0000000      0.0000000       0.000000        0.00000 #>          X63_Y-93..CD4T X64_Y-93..CD4T X65_Y-95..CD4T X61_Y-96..CD4T #> PDK4          0.0000000         0.0000              0       0.000000 #> TNFRSF17      0.0000000         0.0000              0       0.000000 #> ICAM3         3.3914567         2.0018              0       2.292929 #> FAP           0.0000000         0.0000              0       0.000000 #> GZMB          0.3454489         0.0000              0       0.000000 #> TSC2          0.0000000         0.0000              0       0.000000 #>          X62_Y-96..CD4T X61_Y-97..CD4T X61_Y-98..CD4T X60_Y-91..CD4T #> PDK4           0.000000       0.000000       0.000000        0.00000 #> TNFRSF17       0.000000       0.000000       0.000000        0.00000 #> ICAM3          5.364882       2.120614       4.353076        1.18887 #> FAP            0.000000       0.000000       0.000000        0.00000 #> GZMB           0.000000       0.000000       0.000000        0.00000 #> TSC2           0.000000       0.000000       0.000000        0.00000 #>          X65_Y-91..CD4T X61_Y-91..CD4T X64_Y-94..CD4T X64_Y-95..CD4T #> PDK4           0.000000       0.000000      0.0000000       0.000000 #> TNFRSF17       0.000000       0.000000      0.0000000       0.000000 #> ICAM3          2.489443       2.310581      0.7225481       5.138686 #> FAP            0.000000       0.000000      0.0000000       0.000000 #> GZMB           0.000000       0.000000      0.0000000       0.000000 #> TSC2           0.000000       0.000000      0.0000000       0.000000 #>          X63_Y-95..CD4T X62_Y-95..CD4T X61_Y-95..CD4T X58_Y-91..CD4T #> PDK4           0.000000              0       0.000000       0.000000 #> TNFRSF17       0.000000              0       0.000000       0.000000 #> ICAM3          2.544693              0       5.658486       3.247841 #> FAP            0.000000              0       0.000000       0.000000 #> GZMB           0.000000              0       0.000000       0.000000 #> TSC2           0.000000              0       0.000000       0.000000 #>          X56_Y-91..CD4T X59_Y-91..CD4T X57_Y-91..CD4T X54_Y-91..CD4T #> PDK4           0.000000       0.000000      0.0000000              0 #> TNFRSF17       0.000000       0.000000      0.0000000              0 #> ICAM3          1.317707       3.605486      2.9268663              0 #> FAP            0.000000       0.000000      0.0000000              0 #> GZMB           0.000000       0.000000      0.0000000              0 #> TSC2           0.000000       0.000000      0.2696462              0 #>          X56_Y-92..CD4T X59_Y-92..CD4T X57_Y-92..CD4T X60_Y-92..CD4T #> PDK4           0.000000       0.000000              0      0.0000000 #> TNFRSF17       0.000000       0.000000              0      0.0000000 #> ICAM3          1.645508       1.527549              0      1.9806193 #> FAP            0.000000       0.000000              0      0.0000000 #> GZMB           0.000000       0.000000              0      0.0000000 #> TSC2           0.000000       0.000000              0      0.6359124 #>          X55_Y-92..CD4T X58_Y-92..CD4T X60_Y-93..CD4T X59_Y-93..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.449214       3.446105       2.652644       2.574504 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X54_Y-93..CD4T X55_Y-93..CD4T X58_Y-93..CD4T X56_Y-93..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          1.807006       1.718587       1.651578       5.257927 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X57_Y-93..CD4T X55_Y-94..CD4T X57_Y-94..CD4T X56_Y-94..CD4T #> PDK4           0.000000      0.0000000       0.000000       0.000000 #> TNFRSF17       0.000000      0.0000000       0.000000       0.000000 #> ICAM3          2.521216      2.3586099       1.680811       2.741661 #> FAP            0.000000      0.0000000       0.000000       0.000000 #> GZMB           0.000000      0.2513632       0.000000       0.000000 #> TSC2           0.000000      0.0000000       0.000000       0.000000 #>          X60_Y-94..CD4T X59_Y-94..CD4T X54_Y-94..CD4T X57_Y-95..CD4T #> PDK4            0.00000       0.000000       0.000000       0.000000 #> TNFRSF17        0.00000       0.000000       0.000000       0.000000 #> ICAM3           3.21031       4.275866       1.859391       2.652738 #> FAP             0.00000       0.000000       0.000000       0.000000 #> GZMB            0.00000       0.000000       1.005453       0.000000 #> TSC2            0.00000       0.000000       0.000000       0.000000 #>          X56_Y-95..CD4T X59_Y-95..CD4T X55_Y-95..CD4T X56_Y-96..CD4T #> PDK4           0.000000       0.000000       0.000000      0.0000000 #> TNFRSF17       0.000000       0.000000       0.000000      0.0000000 #> ICAM3          2.699097       4.587234       2.781063      3.1043649 #> FAP            0.000000       0.000000       0.000000      0.0000000 #> GZMB           0.000000       0.000000       0.000000      0.2189387 #> TSC2           0.000000       0.000000       0.000000      0.2343499 #>          X58_Y-96..CD4T X57_Y-96..CD4T X55_Y-96..CD4T X59_Y-96..CD4T #> PDK4           0.000000      0.0000000       0.000000        0.00000 #> TNFRSF17       0.000000      0.0000000       0.000000        0.00000 #> ICAM3          1.972455      3.1166299       1.841818        2.19329 #> FAP            0.000000      0.0000000       0.000000        0.00000 #> GZMB           0.000000      0.2189387       0.000000        0.00000 #> TSC2           0.000000      0.4720046       0.000000        0.00000 #>          X55_Y-97..CD4T X57_Y-97..CD4T X56_Y-97..CD4T X58_Y-97..CD4T #> PDK4           0.000000      0.0000000      0.0000000        0.00000 #> TNFRSF17       0.000000      0.0000000      0.0000000        0.00000 #> ICAM3          3.552443      2.2168620      2.2370799        1.65813 #> FAP            0.000000      0.0000000      0.0000000        0.00000 #> GZMB           0.000000      0.0000000      0.2075520        0.00000 #> TSC2           0.372357      0.2376547      0.2376547        0.00000 #>          X59_Y-97..CD4T X55_Y-91..CD4T X56_Y-98..CD4T X74_Y-98..CD4T #> PDK4           0.000000       0.000000      0.0000000              0 #> TNFRSF17       0.000000       0.000000      0.0000000              0 #> ICAM3          2.327773       1.810957      3.1893808              0 #> FAP            0.000000       0.000000      0.0000000              0 #> GZMB           0.000000       0.000000      0.0000000              0 #> TSC2           0.000000       0.000000      0.4297512              0 #>          X73_Y-98..CD4T X76_Y-98..CD4T X78_Y-98..CD4T X77_Y-99..CD4T #> PDK4           0.000000      0.0000000       0.000000       0.000000 #> TNFRSF17       0.000000      0.0000000       0.000000       0.000000 #> ICAM3          3.054983      0.7493335       5.303305       2.928529 #> FAP            0.000000      0.0000000       0.000000       0.000000 #> GZMB           0.000000      0.0000000       0.000000       0.000000 #> TSC2           0.000000      0.0000000       0.000000       0.000000 #>          X76_Y-99..CD4T X76_Y-100..CD4T X77_Y-100..CD4T X75_Y-101..CD4T #> PDK4           0.000000        0.000000        0.000000        0.000000 #> TNFRSF17       0.000000        0.000000        0.000000        0.000000 #> ICAM3          1.650147        5.264283        4.451387        3.912415 #> FAP            0.000000        0.000000        0.000000        0.000000 #> GZMB           0.000000        0.000000        0.000000        0.000000 #> TSC2           0.000000        0.000000        0.000000        0.000000 #>          X74_Y-101..CD4T X75_Y-102..CD4T X78_Y-102..CD4T X73_Y-103..CD4T #> PDK4                   0        0.000000        0.000000        0.000000 #> TNFRSF17               0        0.000000        0.000000        0.000000 #> ICAM3                  0        4.625072        4.585859        2.638130 #> FAP                    0        0.000000        0.000000        0.000000 #> GZMB                   0        0.000000        0.000000        1.218551 #> TSC2                   0        0.000000        0.000000        0.000000 #>          X76_Y-103..CD4T X77_Y-103..CD4T X76_Y-97..CD4T X77_Y-102..CD4T #> PDK4            0.000000        0.000000       0.000000        0.000000 #> TNFRSF17        0.000000        0.000000       0.000000        0.000000 #> ICAM3           5.460237        1.841818       3.189952        2.762726 #> FAP             0.000000        0.000000       0.000000        0.000000 #> GZMB            0.000000        0.000000       0.000000        0.000000 #> TSC2            0.000000        0.000000       0.000000        0.000000 #>          X76_Y-104..CD4T X78_Y-85..CD4T X73_Y-85..CD4T X75_Y-86..CD4T #> PDK4            0.000000       0.000000       0.000000       0.000000 #> TNFRSF17        0.000000       0.000000       0.000000       0.000000 #> ICAM3           5.027855       2.405894       5.303305       4.686998 #> FAP             0.000000       0.000000       0.000000       0.000000 #> GZMB            0.000000       0.000000       0.000000       0.000000 #> TSC2            0.000000       0.000000       0.000000       0.000000 #>          X78_Y-88..CD4T X75_Y-89..CD4T X77_Y-90..CD4T X32_Y-74..CD4T #> PDK4                  0       0.000000       0.000000       0.000000 #> TNFRSF17              0       0.000000       0.000000       0.000000 #> ICAM3                 0       6.121496       5.364882       4.605269 #> FAP                   0       0.000000       0.000000       0.000000 #> GZMB                  0       0.000000       0.000000       0.000000 #> TSC2                  0       0.000000       0.000000       0.000000 #>          X33_Y-79..CD4T X31_Y-73..CD4T X40_Y-72..CD4T X38_Y-71..CD4T #> PDK4                  0        0.00000        0.00000              0 #> TNFRSF17              0        0.00000        0.00000              0 #> ICAM3                 0        5.00494        2.61645              0 #> FAP                   0        0.00000        0.00000              0 #> GZMB                  0        0.00000        0.00000              0 #> TSC2                  0        0.00000        0.00000              0 #>          X37_Y-74..CD4T X40_Y-75..CD4T X37_Y-75..CD4T X39_Y-75..CD4T #> PDK4           0.000000       0.000000              0              0 #> TNFRSF17       0.000000       0.000000              0              0 #> ICAM3          4.557445       3.286341              0              0 #> FAP            0.000000       0.000000              0              0 #> GZMB           4.557445       0.000000              0              0 #> TSC2           0.000000       0.000000              0              0 #>          X38_Y-77..CD4T X42_Y-78..CD4T X38_Y-74..CD4T X77_Y-72..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          5.283602       5.880932       5.283602       1.696462 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       3.912415       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X76_Y-73..CD4T X73_Y-73..CD4T X75_Y-73..CD4T X77_Y-74..CD4T #> PDK4            0.00000      0.0000000       0.000000       0.000000 #> TNFRSF17        0.00000      0.0000000       0.000000       0.000000 #> ICAM3           1.83633      2.9097494       5.121978       2.601444 #> FAP             0.00000      0.0000000       0.000000       0.000000 #> GZMB            0.00000      0.0000000       0.000000       0.000000 #> TSC2            0.00000      0.3079424       0.000000       0.000000 #>          X76_Y-74..CD4T X78_Y-74..CD4T X73_Y-74..CD4T X75_Y-74..CD4T #> PDK4           0.000000              0      0.0000000              0 #> TNFRSF17       0.000000              0      0.0000000              0 #> ICAM3          2.826767              0      1.2482486              0 #> FAP            0.000000              0      0.0000000              0 #> GZMB           0.000000              0      0.6060952              0 #> TSC2           0.000000              0      0.0000000              0 #>          X77_Y-75..CD4T X76_Y-75..CD4T X75_Y-75..CD4T X72_Y-75..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          4.927321       4.036619       3.753336       2.032744 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X74_Y-75..CD4T X76_Y-76..CD4T X74_Y-76..CD4T X77_Y-76..CD4T #> PDK4                  0       0.000000       0.000000        0.00000 #> TNFRSF17              0       0.000000       0.000000        0.00000 #> ICAM3                 0       1.489428       1.274359        2.19329 #> FAP                   0       0.000000       0.000000        0.00000 #> GZMB                  0       0.000000       0.000000        0.00000 #> TSC2                  0       0.000000       0.000000        0.00000 #>          X78_Y-76..CD4T X73_Y-76..CD4T X72_Y-76..CD4T X75_Y-77..CD4T #> PDK4           0.000000       0.000000      0.0000000       0.000000 #> TNFRSF17       0.000000       0.000000      0.0000000       0.000000 #> ICAM3          4.040696       1.325826      0.9054755       2.632142 #> FAP            0.000000       0.000000      0.0000000       0.000000 #> GZMB           4.040696       0.000000      0.0000000       0.000000 #> TSC2           0.000000       0.000000      0.0000000       0.000000 #>          X76_Y-77..CD4T X75_Y-78..CD4T X76_Y-78..CD4T X77_Y-79..CD4T #> PDK4           0.000000       0.000000              0        0.00000 #> TNFRSF17       0.000000       0.000000              0        0.00000 #> ICAM3          2.632142       1.384495              0        3.79076 #> FAP            0.000000       0.000000              0        0.00000 #> GZMB           0.000000       0.000000              0        0.00000 #> TSC2           0.000000       0.000000              0        0.00000 #>          X78_Y-79..CD4T X65_Y-67..CD4T X61_Y-69..CD4T X63_Y-69..CD4T #> PDK4           0.000000       0.000000              0        0.00000 #> TNFRSF17       0.000000       0.000000              0        0.00000 #> ICAM3          4.820628       4.254824              0        3.61014 #> FAP            0.000000       0.000000              0        0.00000 #> GZMB           2.234142       0.000000              0        0.00000 #> TSC2           0.000000       0.000000              0        0.00000 #>          X62_Y-69..CD4T X62_Y-70..CD4T X63_Y-70..CD4T X61_Y-71..CD4T #> PDK4                  0        0.00000        0.00000        0.00000 #> TNFRSF17              0        0.00000        0.00000        0.00000 #> ICAM3                 0        2.23648        2.23648        1.50395 #> FAP                   0        0.00000        0.00000        0.00000 #> GZMB                  0        0.00000        0.00000        0.00000 #> TSC2                  0        0.00000        0.00000        0.00000 #>          X64_Y-72..CD4T X65_Y-73..CD4T X66_Y-73..CD4T X64_Y-71..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.014891       1.884917       1.761771       2.209223 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           2.014891       0.000000       0.000000       0.000000 #>          X65_Y-72..CD4T X63_Y-73..CD4T X67_Y-73..CD4T X65_Y-74..CD4T #> PDK4           0.000000              0      0.0000000       0.000000 #> TNFRSF17       0.000000              0      0.0000000       0.000000 #> ICAM3          2.599872              0      0.8081269       3.438233 #> FAP            0.000000              0      0.0000000       0.000000 #> GZMB           0.000000              0      0.0000000       0.000000 #> TSC2           1.343260              0      0.0000000       0.000000 #>          X64_Y-74..CD4T X66_Y-75..CD4T X65_Y-75..CD4T X67_Y-77..CD4T #> PDK4            0.00000       0.000000       0.000000       0.000000 #> TNFRSF17        0.00000       0.000000       0.000000       0.000000 #> ICAM3           3.08498       3.153173       1.467283       2.584518 #> FAP             0.00000       0.000000       0.000000       0.000000 #> GZMB            0.00000       0.000000       0.000000       0.000000 #> TSC2            0.00000       0.000000       0.000000       0.000000 #>          X61_Y-73..CD4T X67_Y-74..CD4T X66_Y-76..CD4T X66_Y-77..CD4T #> PDK4           0.000000      0.0000000        0.00000       0.000000 #> TNFRSF17       0.000000      0.0000000        0.00000       0.000000 #> ICAM3          4.538951      1.0345371        4.22782       2.584518 #> FAP            0.000000      0.0000000        0.00000       0.000000 #> GZMB           0.000000      0.5000782        0.00000       0.000000 #> TSC2           0.000000      0.0000000        4.22782       0.000000 #>          X72_Y-73..CD4T X72_Y-74..CD4T X68_Y-74..CD4T X71_Y-75..CD4T #> PDK4           0.000000      0.0000000      0.0000000       0.000000 #> TNFRSF17       0.000000      0.0000000      0.0000000       0.000000 #> ICAM3          2.162197      1.6292058      3.0596493       1.155555 #> FAP            0.000000      0.0000000      0.0000000       0.000000 #> GZMB           0.000000      0.3232508      0.2895189       0.000000 #> TSC2           0.000000      0.0000000      0.0000000       0.000000 #>          X69_Y-75..CD4T X68_Y-75..CD4T X67_Y-75..CD4T X73_Y-75..CD4T #> PDK4          0.0000000       0.000000        0.00000       0.000000 #> TNFRSF17      0.0000000       0.000000        0.00000       0.000000 #> ICAM3         3.3821229       4.289524        2.08581       2.487806 #> FAP           0.0000000       0.000000        0.00000       0.000000 #> GZMB          0.0000000       0.000000        0.00000       0.000000 #> TSC2          0.3123506       0.000000        0.00000       0.000000 #>          X69_Y-76..CD4T X68_Y-76..CD4T X67_Y-76..CD4T X71_Y-76..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          3.047288       2.247907       1.602073       3.473269 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X70_Y-76..CD4T X69_Y-77..CD4T X71_Y-77..CD4T X70_Y-77..CD4T #> PDK4          0.0000000      0.0000000       0.000000       0.000000 #> TNFRSF17      0.0000000      0.0000000       0.000000       0.000000 #> ICAM3         4.0868514      3.0856368       3.866558       3.908443 #> FAP           0.0000000      0.0000000       0.000000       0.000000 #> GZMB          0.5520912      0.1988493       0.000000       0.000000 #> TSC2          0.0000000      0.0000000       0.000000       0.000000 #>          X72_Y-77..CD4T X71_Y-78..CD4T X69_Y-78..CD4T X70_Y-78..CD4T #> PDK4           0.000000      0.0000000      0.0000000      0.0000000 #> TNFRSF17       0.000000      0.0000000      0.0000000      0.0000000 #> ICAM3          2.643846      2.2127911      2.0131060      2.8925060 #> FAP            0.000000      0.0000000      0.0000000      0.0000000 #> GZMB           0.000000      0.5144518      0.2001511      0.2411979 #> TSC2           0.000000      0.0000000      0.0000000      0.0000000 #>          X72_Y-78..CD4T X70_Y-79..CD4T X71_Y-79..CD4T X71_Y-74..CD4T #> PDK4           0.000000      0.0000000      0.0000000       0.000000 #> TNFRSF17       0.000000      0.0000000      0.0000000       0.000000 #> ICAM3          3.307508      3.0361559      3.2645628       1.489459 #> FAP            0.000000      0.0000000      0.0000000       0.000000 #> GZMB           0.000000      0.3030476      0.2369989       0.000000 #> TSC2           0.000000      0.0000000      0.0000000       0.000000 #>          X68_Y-77..CD4T X58_Y-74..CD4T X54_Y-77..CD4T X55_Y-78..CD4T #> PDK4          0.0000000       0.000000      0.0000000        0.00000 #> TNFRSF17      0.0000000       0.000000      0.0000000        0.00000 #> ICAM3         2.5199497       2.004158      2.6390275        2.80005 #> FAP           0.0000000       0.000000      0.0000000        0.00000 #> GZMB          0.2209437       1.878748      0.3897001        0.00000 #> TSC2          0.0000000       0.000000      0.0000000        0.00000 #>          X54_Y-78..CD4T X56_Y-79..CD4T X55_Y-79..CD4T X54_Y-79..CD4T #> PDK4           0.000000        0.00000       0.000000      0.0000000 #> TNFRSF17       0.000000        0.00000       0.000000      0.0000000 #> ICAM3          1.890642        1.83463       3.610104      2.9299549 #> FAP            0.000000        0.00000       0.000000      0.0000000 #> GZMB           0.000000        0.00000       0.000000      0.5121822 #> TSC2           0.000000        0.00000       0.000000      0.0000000 #>          X73_Y-66..CD4T X73_Y-67..CD4T X68_Y-67..CD4T X73_Y-68..CD4T #> PDK4          0.0000000      0.0000000              0      0.0000000 #> TNFRSF17      0.0000000      0.0000000              0      0.0000000 #> ICAM3         2.5303233      2.7020591              0      2.4101008 #> FAP           0.0000000      0.0000000              0      0.0000000 #> GZMB          0.0000000      0.2338201              0      0.4589269 #> TSC2          0.5249983      0.0000000              0      0.2399883 #>          X69_Y-69..CD4T X72_Y-69..CD4T X73_Y-69..CD4T X70_Y-70..CD4T #> PDK4                  0        0.00000      0.0000000       0.000000 #> TNFRSF17              0        0.00000      0.0000000       0.000000 #> ICAM3                 0        0.00000      2.5002902       4.787888 #> FAP                   0        0.00000      0.0000000       0.000000 #> GZMB                  0        0.00000      0.3788075       0.000000 #> TSC2                  0        4.99761      0.0000000       0.000000 #>          X73_Y-70..CD4T X72_Y-71..CD4T X67_Y-71..CD4T X72_Y-72..CD4T #> PDK4           0.000000      0.0000000              0      0.0000000 #> TNFRSF17       0.000000      0.0000000              0      0.0000000 #> ICAM3          2.746235      2.0443150              0      2.7766650 #> FAP            0.000000      0.0000000              0      0.0000000 #> GZMB           0.000000      0.4968785              0      0.8517918 #> TSC2           0.000000      0.0000000              0      0.0000000 #>          X73_Y-72..CD4T X69_Y-68..CD4T X72_Y-68..CD4T X72_Y-70..CD4T #> PDK4           0.000000              0        0.00000              0 #> TNFRSF17       0.000000              0        0.00000              0 #> ICAM3          4.084259              0        5.44192              0 #> FAP            0.000000              0        0.00000              0 #> GZMB           1.426902              0        0.00000              0 #> TSC2           0.000000              0        0.00000              0 #>          X73_Y-71..CD4T X52_Y-73..CD4T X49_Y-73..CD4T X53_Y-74..CD4T #> PDK4           0.000000      0.0000000         0.0000      0.0000000 #> TNFRSF17       0.000000      0.0000000         0.0000      0.0000000 #> ICAM3          2.595133      2.6717415         4.0799      2.2137032 #> FAP            0.000000      0.0000000         0.0000      0.0000000 #> GZMB           0.376948      0.0000000         0.0000      0.8089178 #> TSC2           0.000000      0.2264917         0.0000      0.0000000 #>          X52_Y-74..CD4T X53_Y-75..CD4T X52_Y-75..CD4T X53_Y-76..CD4T #> PDK4          0.0000000      0.0000000      0.0000000      0.0000000 #> TNFRSF17      0.0000000      0.0000000      0.0000000      0.0000000 #> ICAM3         2.7127532      2.4103171      2.4600836      3.7515088 #> FAP           0.0000000      0.0000000      0.0000000      0.0000000 #> GZMB          0.4793066      0.4355722      0.0000000      0.0000000 #> TSC2          0.0000000      0.4035223      0.5044029      0.6771505 #>          X54_Y-76..CD4T X48_Y-77..CD4T X49_Y-78..CD4T X48_Y-78..CD4T #> PDK4          0.0000000       0.000000       0.000000       0.000000 #> TNFRSF17      0.0000000       0.000000       0.000000       0.000000 #> ICAM3         2.3163880       2.300271       2.396969       2.699894 #> FAP           0.0000000       0.000000       0.000000       0.000000 #> GZMB          0.5196002       0.000000       0.000000       0.000000 #> TSC2          0.0000000       0.000000       0.000000       0.000000 #>          X50_Y-78..CD4T X53_Y-78..CD4T X52_Y-78..CD4T X50_Y-79..CD4T #> PDK4          0.0000000       0.000000       0.000000      0.0000000 #> TNFRSF17      0.0000000       0.000000       0.000000      0.0000000 #> ICAM3         2.8139101       2.719675       2.002833      2.5727569 #> FAP           0.0000000       0.000000       0.000000      0.0000000 #> GZMB          0.2859526       0.000000       0.000000      0.6173570 #> TSC2          0.0000000       0.000000       0.000000      0.2771736 #>          X53_Y-79..CD4T X49_Y-79..CD4T X52_Y-79..CD4T X54_Y-72..CD4T #> PDK4           0.000000      0.0000000       0.000000              0 #> TNFRSF17       0.000000      0.0000000       0.000000              0 #> ICAM3          2.501836      1.6564799       2.449483              0 #> FAP            0.000000      0.0000000       0.000000              0 #> GZMB           0.275654      0.0000000       0.000000              0 #> TSC2           0.000000      0.2217389       0.000000              0 #>          X52_Y-72..CD4T X51_Y-73..CD4T X51_Y-74..CD4T X44_Y-91..CD4T #> PDK4          0.0000000      0.0000000              0      0.0000000 #> TNFRSF17      0.0000000      0.0000000              0      0.0000000 #> ICAM3         1.9846965      1.2741764              0      2.8864227 #> FAP           0.0000000      0.0000000              0      0.0000000 #> GZMB          0.0000000      0.7058355              0      0.0000000 #> TSC2          0.4529834      0.0000000              0      0.2221676 #>          X46_Y-91..CD4T X48_Y-91..CD4T X47_Y-91..CD4T X45_Y-91..CD4T #> PDK4           0.000000        0.00000       0.000000       0.000000 #> TNFRSF17       0.000000        0.00000       0.000000       0.000000 #> ICAM3          2.985732        1.99598       2.187212       3.577819 #> FAP            0.000000        0.00000       0.000000       0.000000 #> GZMB           0.000000        0.00000       0.000000       0.000000 #> TSC2           0.000000        0.00000       0.000000       0.000000 #>          X43_Y-91..CD4T X43_Y-92..CD4T X45_Y-92..CD4T X47_Y-92..CD4T #> PDK4                  0       0.000000       0.000000      0.0000000 #> TNFRSF17              0       0.000000       0.000000      0.0000000 #> ICAM3                 0       5.141390       3.381131      2.1581818 #> FAP                   0       0.000000       0.000000      0.0000000 #> GZMB                  0       0.000000       0.000000      0.0000000 #> TSC2                  0       1.081453       0.000000      0.4888767 #>          X46_Y-92..CD4T X44_Y-92..CD4T X42_Y-92..CD4T X47_Y-93..CD4T #> PDK4           0.000000       0.000000       0.000000         0.0000 #> TNFRSF17       0.000000       0.000000       0.000000         0.0000 #> ICAM3          2.163602       3.008183       2.851665         2.9947 #> FAP            0.000000       0.000000       0.000000         0.0000 #> GZMB           0.000000       0.000000       0.000000         0.0000 #> TSC2           0.439989       0.000000       0.000000         0.0000 #>          X44_Y-93..CD4T X45_Y-93..CD4T X46_Y-93..CD4T X46_Y-94..CD4T #> PDK4           0.000000       0.000000        0.00000       0.000000 #> TNFRSF17       0.000000       0.000000        0.00000       0.000000 #> ICAM3          2.466472       3.459759        3.07575       2.415677 #> FAP            0.000000       0.000000        0.00000       0.000000 #> GZMB           0.000000       0.000000        0.00000       0.000000 #> TSC2           0.000000       0.000000        0.00000       0.000000 #>          X45_Y-94..CD4T X44_Y-94..CD4T X46_Y-95..CD4T X45_Y-95..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.741632       4.790279       2.449616       2.386433 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X44_Y-95..CD4T X44_Y-96..CD4T X45_Y-96..CD4T X46_Y-96..CD4T #> PDK4           0.000000      0.0000000       0.000000        0.00000 #> TNFRSF17       0.000000      0.0000000       0.000000        0.00000 #> ICAM3          2.309367      2.7275589       1.800479        1.73217 #> FAP            0.000000      0.0000000       0.000000        0.00000 #> GZMB           0.000000      0.6711014       0.469771        0.00000 #> TSC2           0.000000      0.0000000       0.000000        0.00000 #>          X46_Y-97..CD4T X44_Y-97..CD4T X48_Y-92..CD4T X47_Y-97..CD4T #> PDK4           0.000000       0.000000       0.000000              0 #> TNFRSF17       0.000000       0.000000       0.000000              0 #> ICAM3          1.568517       1.680811       1.262893              0 #> FAP            0.000000       0.000000       0.000000              0 #> GZMB           0.000000       0.000000       0.000000              0 #> TSC2           0.000000       0.000000       0.000000              0 #>          X43_Y-98..CD4T X25_Y-74..CD4T X33_Y-70..CD4T X33_Y-71..CD4T #> PDK4           0.000000        0.00000       0.000000              0 #> TNFRSF17       0.000000        0.00000       0.000000              0 #> ICAM3          3.648973        5.84594       4.268613              0 #> FAP            0.000000        0.00000       0.000000              0 #> GZMB           0.000000        0.00000       0.000000              0 #> TSC2           0.000000        0.00000       0.000000              0 #>          X29_Y-72..CD4T X35_Y-82..CD4T X35_Y-81..CD4T X28_Y-80..CD4T #> PDK4           0.000000              0              0       0.000000 #> TNFRSF17       0.000000              0              0       0.000000 #> ICAM3          2.411979              0              0       4.940848 #> FAP            0.000000              0              0       0.000000 #> GZMB           0.000000              0              0       0.000000 #> TSC2           0.000000              0              0       0.000000 #>          X24_Y-83..CD4T X25_Y-68..CD4T X30_Y-68..CD4T X23_Y-79..CD4T #> PDK4           0.000000       0.000000              0       0.000000 #> TNFRSF17       0.000000       0.000000              0       0.000000 #> ICAM3          5.812138       4.378773              0       4.764556 #> FAP            0.000000       0.000000              0       0.000000 #> GZMB           0.000000       0.000000              0       0.000000 #> TSC2           0.000000       0.000000              0       0.000000 #>          X45_Y-66..CD4T X46_Y-66..CD4T X53_Y-64..CD4T X53_Y-65..CD4T #> PDK4           0.000000       0.000000        0.00000       0.000000 #> TNFRSF17       0.000000       0.000000        0.00000       0.000000 #> ICAM3          4.402383       5.681529        2.90065       2.606103 #> FAP            0.000000       0.000000        0.00000       0.000000 #> GZMB           0.000000       0.000000        0.00000       0.000000 #> TSC2           0.000000       0.000000        0.00000       0.000000 #>          X52_Y-65..CD4T X54_Y-65..CD4T X55_Y-65..CD4T X51_Y-65..CD4T #> PDK4           0.000000      0.0000000       0.000000        0.00000 #> TNFRSF17       0.000000      0.0000000       0.000000        0.00000 #> ICAM3          2.392239      2.3838229       2.971039        1.89856 #> FAP            0.000000      0.0000000       0.000000        0.00000 #> GZMB           0.000000      0.3839662       0.000000        0.00000 #> TSC2           0.000000      0.0000000       0.000000        0.00000 #>          X52_Y-66..CD4T X51_Y-66..CD4T X49_Y-66..CD4T X48_Y-66..CD4T #> PDK4          0.0000000       0.000000              0              0 #> TNFRSF17      0.0000000       0.000000              0              0 #> ICAM3         2.9298193       1.437792              0              0 #> FAP           0.0000000       0.000000              0              0 #> GZMB          0.0000000       0.000000              0              0 #> TSC2          0.2606045       0.000000              0              0 #>          X51_Y-67..CD4T X52_Y-67..CD4T X54_Y-64..CD4T X53_Y-66..CD4T #> PDK4          0.0000000      0.0000000      0.0000000       0.000000 #> TNFRSF17      0.0000000      0.0000000      0.0000000       0.000000 #> ICAM3         1.2010792      1.7090820      2.7558473       2.018587 #> FAP           0.0000000      0.0000000      0.0000000       0.000000 #> GZMB          0.8802377      0.8802377      0.4479606       0.000000 #> TSC2          0.0000000      0.0000000      0.0000000       0.000000 #>          X37_Y-82..CD4T X41_Y-83..CD4T X48_Y-73..CD4T X45_Y-73..CD4T #> PDK4                  0       0.000000        0.00000              0 #> TNFRSF17              0       0.000000        0.00000              0 #> ICAM3                 0       5.343928        0.00000              0 #> FAP                   0       0.000000        0.00000              0 #> GZMB                  0       4.655546        4.70854              0 #> TSC2                  0       0.000000        0.00000              0 #>          X47_Y-73..CD4T X46_Y-73..CD4T X47_Y-74..CD4T X43_Y-74..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          4.053026       1.272347       2.472211       4.254824 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X46_Y-74..CD4T X44_Y-74..CD4T X46_Y-75..CD4T X47_Y-75..CD4T #> PDK4           0.000000       0.000000        0.00000       0.000000 #> TNFRSF17       0.000000       0.000000        0.00000       0.000000 #> ICAM3          1.771937       4.954735        0.69184       1.387834 #> FAP            0.000000       0.000000        0.00000       0.000000 #> GZMB           0.000000       0.000000        0.00000       0.000000 #> TSC2           0.000000       0.000000        0.00000       0.000000 #>          X43_Y-75..CD4T X45_Y-75..CD4T X46_Y-76..CD4T X44_Y-76..CD4T #> PDK4           0.000000              0      0.0000000       0.000000 #> TNFRSF17       0.000000              0      0.0000000       0.000000 #> ICAM3          2.370883              0      1.3788880       3.976987 #> FAP            0.000000              0      0.0000000       0.000000 #> GZMB           0.000000              0      0.4990333       0.000000 #> TSC2           2.370883              0      0.0000000       0.000000 #>          X47_Y-76..CD4T X45_Y-77..CD4T X47_Y-77..CD4T X46_Y-77..CD4T #> PDK4          0.0000000        0.00000       0.000000      0.0000000 #> TNFRSF17      0.0000000        0.00000       0.000000      0.0000000 #> ICAM3         1.7798896        3.85601       3.583673      2.8451320 #> FAP           0.0000000        0.00000       0.000000      0.0000000 #> GZMB          0.4536667        0.00000       0.000000      0.0000000 #> TSC2          0.0000000        0.00000       0.000000      0.9774357 #>          X43_Y-77..CD4T X44_Y-78..CD4T X47_Y-78..CD4T X46_Y-78..CD4T #> PDK4           0.000000       0.000000       0.000000      0.0000000 #> TNFRSF17       0.000000       0.000000       0.000000      0.0000000 #> ICAM3          4.243257       4.720328       2.515943      2.9498188 #> FAP            0.000000       0.000000       0.000000      0.0000000 #> GZMB           0.000000       0.000000       0.000000      0.3505727 #> TSC2           0.000000       0.000000       0.000000      0.3759368 #>          X45_Y-78..CD4T X43_Y-78..CD4T X46_Y-79..CD4T X44_Y-79..CD4T #> PDK4           0.000000              0      0.0000000              0 #> TNFRSF17       0.000000              0      0.0000000              0 #> ICAM3          2.933036              0      3.3127721              0 #> FAP            0.000000              0      0.0000000              0 #> GZMB           0.000000              0      0.2278723              0 #> TSC2           0.000000              0      0.0000000              0 #>          X45_Y-79..CD4T X47_Y-79..CD4T X48_Y-79..CD4T X47_Y-72..CD4T #> PDK4          0.0000000       0.000000       0.000000       0.000000 #> TNFRSF17      0.0000000       0.000000       0.000000       0.000000 #> ICAM3         3.1908962       2.050485       1.842319       3.512688 #> FAP           0.0000000       0.000000       0.000000       0.000000 #> GZMB          0.0000000       0.000000       0.000000       0.000000 #> TSC2          0.3477538       0.000000       0.000000       0.000000 #>          X42_Y-76..CD4T X44_Y-77..CD4T X75_Y-80..CD4T X76_Y-80..CD4T #> PDK4           0.000000        0.00000         0.0000       0.000000 #> TNFRSF17       0.000000        0.00000         0.0000       0.000000 #> ICAM3          5.697193        2.19329         2.5279       2.247022 #> FAP            0.000000        0.00000         0.0000       0.000000 #> GZMB           0.000000        0.00000         0.0000       0.000000 #> TSC2           4.605269        0.00000         0.0000       0.000000 #>          X76_Y-81..CD4T X77_Y-81..CD4T X75_Y-81..CD4T X78_Y-82..CD4T #> PDK4          0.0000000      0.0000000       0.000000       0.000000 #> TNFRSF17      0.0000000      0.0000000       0.000000       0.000000 #> ICAM3         1.9651102      2.1705557       3.532326       4.099151 #> FAP           0.0000000      0.0000000       0.000000       0.000000 #> GZMB          0.0000000      0.5601438       0.000000       0.000000 #> TSC2          0.6158943      0.0000000       1.231789       0.000000 #>          X76_Y-82..CD4T X77_Y-82..CD4T X78_Y-83..CD4T X77_Y-83..CD4T #> PDK4           0.000000       0.000000       0.000000        0.00000 #> TNFRSF17       0.000000       0.000000       0.000000        0.00000 #> ICAM3          2.723407       2.794452       1.989258        1.77721 #> FAP            0.000000       0.000000       0.000000        0.00000 #> GZMB           0.000000       0.000000       0.000000        0.00000 #> TSC2           0.000000       0.000000       0.000000        0.00000 #>          X78_Y-84..CD4T X78_Y-81..CD4T X79_Y-83..CD4T X79_Y-84..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          1.727245       3.972802       2.486573       1.989258 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X74_Y-66..CD4T X72_Y-66..CD4T X74_Y-67..CD4T X76_Y-67..CD4T #> PDK4          0.0000000      0.0000000      0.0000000              0 #> TNFRSF17      0.0000000      0.0000000      0.0000000              0 #> ICAM3         2.9681365      2.3115971      2.7792518              0 #> FAP           0.0000000      0.0000000      0.0000000              0 #> GZMB          0.0000000      0.0000000      0.4755478              0 #> TSC2          0.6045352      0.3211678      0.0000000              0 #>          X75_Y-67..CD4T X78_Y-67..CD4T X74_Y-68..CD4T X76_Y-68..CD4T #> PDK4          0.0000000              0      0.0000000       0.000000 #> TNFRSF17      0.0000000              0      0.0000000       0.000000 #> ICAM3         2.5835230              0      2.9288163       1.027737 #> FAP           0.0000000              0      0.0000000       0.000000 #> GZMB          0.5858747              0      0.2189387       0.000000 #> TSC2          0.0000000              0      0.2376547       0.000000 #>          X77_Y-68..CD4T X75_Y-68..CD4T X78_Y-68..CD4T X74_Y-69..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          4.002422       2.187484       4.817691       2.678261 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X75_Y-69..CD4T X76_Y-69..CD4T X78_Y-69..CD4T X77_Y-69..CD4T #> PDK4          0.0000000      0.0000000              0       0.000000 #> TNFRSF17      0.0000000      0.0000000              0       0.000000 #> ICAM3         2.5489807      2.4360164              0       1.433086 #> FAP           0.0000000      0.0000000              0       0.000000 #> GZMB          0.3318059      0.0000000              0       0.000000 #> TSC2          0.0000000      0.4311194              0       0.000000 #>          X77_Y-70..CD4T X74_Y-70..CD4T X76_Y-70..CD4T X75_Y-70..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          1.675755       3.220413       2.695886       2.369243 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X74_Y-71..CD4T X78_Y-71..CD4T X74_Y-72..CD4T X78_Y-72..CD4T #> PDK4          0.0000000       0.000000      0.0000000       0.000000 #> TNFRSF17      0.0000000       0.000000      0.0000000       0.000000 #> ICAM3         2.5402445       2.388077      3.3137032       1.194038 #> FAP           0.0000000       0.000000      0.0000000       0.000000 #> GZMB          0.4887265       0.000000      0.8948206       0.000000 #> TSC2          0.0000000       0.000000      0.0000000       0.000000 #>          X76_Y-72..CD4T X74_Y-73..CD4T X56_Y-66..CD4T X58_Y-66..CD4T #> PDK4                  0       0.000000       0.000000      0.0000000 #> TNFRSF17              0       0.000000       0.000000      0.0000000 #> ICAM3                 0       2.611758       2.922171      3.9124797 #> FAP                   0       0.000000       0.000000      0.0000000 #> GZMB                  0       0.000000       0.000000      0.9506189 #> TSC2                  0       1.140373       0.000000      0.0000000 #>          X56_Y-67..CD4T X59_Y-67..CD4T X57_Y-67..CD4T X60_Y-67..CD4T #> PDK4           0.000000       0.000000      0.0000000       0.000000 #> TNFRSF17       0.000000       0.000000      0.0000000       0.000000 #> ICAM3          4.654690       1.516052      4.1885277       1.096645 #> FAP            0.000000       0.000000      0.0000000       0.000000 #> GZMB           0.000000       1.584365      0.0000000       1.153780 #> TSC2           1.483796       1.516052      0.8902773       0.000000 #>          X59_Y-68..CD4T X60_Y-68..CD4T X58_Y-68..CD4T X58_Y-69..CD4T #> PDK4                  0      0.0000000              0              0 #> TNFRSF17              0      0.0000000              0              0 #> ICAM3                 0      1.7562058              0              0 #> FAP                   0      0.0000000              0              0 #> GZMB                  0      0.9230241              0              0 #> TSC2                  0      0.0000000              0              0 #>          X57_Y-70..CD4T X60_Y-70..CD4T X57_Y-66..CD4T X58_Y-67..CD4T #> PDK4           0.000000       0.000000        0.00000       0.000000 #> TNFRSF17       0.000000       0.000000        0.00000       0.000000 #> ICAM3          4.040696       4.999905        3.58642       2.216657 #> FAP            0.000000       0.000000        0.00000       0.000000 #> GZMB           0.000000       0.000000        0.00000       1.188274 #> TSC2           0.000000       2.661704        0.00000       1.137039 #>          X55_Y-68..CD4T X59_Y-69..CD4T X48_Y-80..CD4T X45_Y-80..CD4T #> PDK4                  0       0.000000      0.0000000      0.0000000 #> TNFRSF17              0       0.000000      0.0000000      0.0000000 #> ICAM3                 0       3.017342      2.4498545      2.3347666 #> FAP                   0       0.000000      0.0000000      0.0000000 #> GZMB                  0       0.000000      0.0000000      0.0000000 #> TSC2                  0       0.000000      0.3745158      0.3477538 #>          X46_Y-80..CD4T X47_Y-80..CD4T X44_Y-80..CD4T X43_Y-80..CD4T #> PDK4           0.000000        0.00000       0.000000       0.000000 #> TNFRSF17       0.000000        0.00000       0.000000       0.000000 #> ICAM3          2.026973        2.06113       3.022048       2.498805 #> FAP            0.000000        0.00000       0.000000       0.000000 #> GZMB           0.000000        0.00000       0.000000       0.000000 #> TSC2           0.000000        0.00000       0.000000       0.000000 #>          X44_Y-81..CD4T X45_Y-81..CD4T X46_Y-81..CD4T X47_Y-81..CD4T #> PDK4           0.000000       0.000000      0.0000000       0.000000 #> TNFRSF17       0.000000       0.000000      0.0000000       0.000000 #> ICAM3          3.243220       2.122589      3.2304350       3.361997 #> FAP            0.000000       0.000000      0.0000000       0.000000 #> GZMB           0.463297       0.000000      0.3729817       0.000000 #> TSC2           0.000000       0.000000      0.3305225       0.000000 #>          X46_Y-82..CD4T X45_Y-82..CD4T X44_Y-82..CD4T X47_Y-82..CD4T #> PDK4          0.0000000       0.000000       0.000000       0.000000 #> TNFRSF17      0.0000000       0.000000       0.000000       0.000000 #> ICAM3         2.6213040       1.861670       1.302123       2.196719 #> FAP           0.0000000       0.000000       0.000000       0.000000 #> GZMB          0.5975719       0.000000       0.000000       0.689506 #> TSC2          0.0000000       0.372357       1.117071       0.000000 #>          X44_Y-83..CD4T X45_Y-83..CD4T X43_Y-83..CD4T X46_Y-83..CD4T #> PDK4           0.000000      0.0000000              0      0.0000000 #> TNFRSF17       0.000000      0.0000000              0      0.0000000 #> ICAM3          2.342666      2.7795192              0      3.0657195 #> FAP            0.000000      0.0000000              0      0.0000000 #> GZMB           0.000000      0.0000000              0      0.0000000 #> TSC2           0.000000      0.4855019              0      0.4315573 #>          X44_Y-84..CD4T X43_Y-84..CD4T X44_Y-85..CD4T X43_Y-85..CD4T #> PDK4           0.000000      0.0000000      0.0000000      0.0000000 #> TNFRSF17       0.000000      0.0000000      0.0000000      0.0000000 #> ICAM3          3.675083      3.1547966      2.2859938      3.1308372 #> FAP            0.000000      0.0000000      0.0000000      0.0000000 #> GZMB           0.000000      0.0000000      0.0000000      0.0000000 #> TSC2           0.000000      0.3095145      0.3403699      0.2280633 #>          X42_Y-85..CD4T X43_Y-81..CD4T X43_Y-82..CD4T X51_Y-91..CD4T #> PDK4           0.000000       0.000000       0.000000      0.0000000 #> TNFRSF17       0.000000       0.000000       0.000000      0.0000000 #> ICAM3          3.970494       5.027264       2.513632      0.9342106 #> FAP            0.000000       0.000000       0.000000      0.0000000 #> GZMB           0.000000       0.000000       0.000000      0.0000000 #> TSC2           0.000000       0.000000       0.000000      0.0000000 #>          X49_Y-91..CD4T X53_Y-92..CD4T X51_Y-92..CD4T X54_Y-92..CD4T #> PDK4           0.000000       0.000000       0.000000              0 #> TNFRSF17       0.000000       0.000000       0.000000              0 #> ICAM3          2.041831       1.547737       1.584365              0 #> FAP            0.000000       0.000000       0.000000              0 #> GZMB           0.000000       0.000000       0.000000              0 #> TSC2           0.000000       0.000000       0.000000              0 #>          X53_Y-93..CD4T X49_Y-93..CD4T X51_Y-94..CD4T X51_Y-96..CD4T #> PDK4           0.000000         0.0000              0       0.000000 #> TNFRSF17       0.000000         0.0000              0       0.000000 #> ICAM3          2.112783         1.7443              0       4.577379 #> FAP            0.000000         0.0000              0       0.000000 #> GZMB           0.000000         0.0000              0       2.159238 #> TSC2           0.000000         0.0000              0       0.000000 #>          X50_Y-91..CD4T X50_Y-92..CD4T X52_Y-92..CD4T X49_Y-92..CD4T #> PDK4           0.000000       0.000000       0.000000         0.0000 #> TNFRSF17       0.000000       0.000000       0.000000         0.0000 #> ICAM3          1.318517       0.000000       2.373715         1.7443 #> FAP            0.000000       0.000000       0.000000         0.0000 #> GZMB           0.000000       0.000000       0.000000         0.0000 #> TSC2           0.445484       1.696173       0.000000         0.0000 #>          X52_Y-96..CD4T X72_Y-79..CD4T X71_Y-80..CD4T X70_Y-80..CD4T #> PDK4           0.000000       0.000000       0.000000      0.0000000 #> TNFRSF17       0.000000       0.000000       0.000000      0.0000000 #> ICAM3          4.577379       2.782646       3.260614      2.8330046 #> FAP            0.000000       0.000000       0.000000      0.0000000 #> GZMB           2.159238       0.000000       0.000000      0.3229489 #> TSC2           0.000000       0.000000       0.000000      0.0000000 #>          X71_Y-81..CD4T X71_Y-82..CD4T X72_Y-82..CD4T X70_Y-82..CD4T #> PDK4            0.00000       0.000000       0.000000       0.000000 #> TNFRSF17        0.00000       0.000000       0.000000       0.000000 #> ICAM3           2.48785       2.544154       3.382456       2.556642 #> FAP             0.00000       0.000000       0.000000       0.000000 #> GZMB            0.00000       0.000000       0.000000       0.000000 #> TSC2            0.00000       0.000000       0.000000       0.000000 #>          X71_Y-83..CD4T X70_Y-83..CD4T X70_Y-84..CD4T X69_Y-84..CD4T #> PDK4          0.0000000      0.0000000      0.0000000      0.0000000 #> TNFRSF17      0.0000000      0.0000000      0.0000000      0.0000000 #> ICAM3         2.8190836      4.0227149      3.7805610      2.8066028 #> FAP           0.0000000      0.0000000      0.0000000      0.0000000 #> GZMB          0.0000000      0.0000000      0.1912612      0.4205541 #> TSC2          0.5732323      0.3275613      0.0000000      0.0000000 #>          X66_Y-84..CD4T X68_Y-84..CD4T X71_Y-84..CD4T X67_Y-84..CD4T #> PDK4           0.000000      0.0000000       0.000000      0.0000000 #> TNFRSF17       0.000000      0.0000000       0.000000      0.0000000 #> ICAM3          2.579774      3.2852575       4.023536      2.7081877 #> FAP            0.000000      0.0000000       0.000000      0.0000000 #> GZMB           0.000000      0.6980842       0.000000      0.4766301 #> TSC2           0.000000      0.2322641       0.000000      0.0000000 #>          X68_Y-85..CD4T X69_Y-85..CD4T X70_Y-85..CD4T X67_Y-85..CD4T #> PDK4          0.0000000      0.0000000       0.000000      0.0000000 #> TNFRSF17      0.0000000      0.0000000       0.000000      0.0000000 #> ICAM3         3.1814777      2.7630776       2.748494      2.3801721 #> FAP           0.0000000      0.0000000       0.000000      0.0000000 #> GZMB          0.6681477      0.2292929       0.000000      0.6619542 #> TSC2          0.4478238      0.0000000       0.000000      0.4750883 #>          X68_Y-79..CD4T X50_Y-67..CD4T X48_Y-67..CD4T X51_Y-68..CD4T #> PDK4           0.000000       0.000000       0.000000      0.0000000 #> TNFRSF17       0.000000       0.000000       0.000000      0.0000000 #> ICAM3          4.275582       2.417919       4.132759      3.3378203 #> FAP            0.000000       0.000000       0.000000      0.0000000 #> GZMB           0.000000       0.000000       0.000000      0.0000000 #> TSC2           0.000000       0.000000       0.000000      0.2242739 #>          X52_Y-68..CD4T X50_Y-68..CD4T X49_Y-68..CD4T X48_Y-68..CD4T #> PDK4          0.0000000         0.0000      0.0000000       0.000000 #> TNFRSF17      0.0000000         0.0000      0.0000000       0.000000 #> ICAM3         2.4493445         1.7684      0.8019646       4.626021 #> FAP           0.0000000         0.0000      0.0000000       0.000000 #> GZMB          0.4548155         0.0000      0.7675449       0.000000 #> TSC2          0.0000000         0.0000      0.0000000       0.000000 #>          X51_Y-69..CD4T X49_Y-69..CD4T X50_Y-69..CD4T X52_Y-69..CD4T #> PDK4          0.0000000       0.000000      0.0000000       0.000000 #> TNFRSF17      0.0000000       0.000000      0.0000000       0.000000 #> ICAM3         2.6955067       2.413745      1.1322411       3.862567 #> FAP           0.0000000       0.000000      0.0000000       0.000000 #> GZMB          0.0000000       1.410509      0.5502978       0.000000 #> TSC2          0.2274077       0.000000      0.0000000       0.000000 #>          X48_Y-69..CD4T X51_Y-70..CD4T X49_Y-70..CD4T X52_Y-70..CD4T #> PDK4           0.000000      0.0000000       0.000000      0.0000000 #> TNFRSF17       0.000000      0.0000000       0.000000      0.0000000 #> ICAM3          4.626021      3.4586830       2.359365      3.2520373 #> FAP            0.000000      0.0000000       0.000000      0.0000000 #> GZMB           0.000000      0.2449072       1.082892      0.3469518 #> TSC2           0.000000      0.0000000       0.000000      0.0000000 #>          X48_Y-70..CD4T X51_Y-71..CD4T X52_Y-71..CD4T X48_Y-72..CD4T #> PDK4            0.00000       0.000000       0.000000              0 #> TNFRSF17        0.00000       0.000000       0.000000              0 #> ICAM3           2.94201       1.908959       2.129468              0 #> FAP             0.00000       0.000000       0.000000              0 #> GZMB            0.00000       0.000000       0.000000              0 #> TSC2            0.00000       0.000000       0.000000              0 #>          X65_Y-65..CD4T X57_Y-80..CD4T X54_Y-80..CD4T X56_Y-80..CD4T #> PDK4                  0       0.000000      0.0000000        0.00000 #> TNFRSF17              0       0.000000      0.0000000        0.00000 #> ICAM3                 0       1.790643      2.2859167        2.21147 #> FAP                   0       0.000000      0.0000000        0.00000 #> GZMB                  0       0.000000      0.7873398        0.00000 #> TSC2                  0       0.000000      0.0000000        0.00000 #>          X55_Y-80..CD4T X59_Y-80..CD4T X58_Y-80..CD4T X55_Y-81..CD4T #> PDK4          0.0000000       0.000000       0.000000       0.000000 #> TNFRSF17      0.0000000       0.000000       0.000000       0.000000 #> ICAM3         1.6617296       0.000000       1.235212       2.272359 #> FAP           0.0000000       0.000000       0.000000       0.000000 #> GZMB          0.4030235       2.889724       1.444862       0.000000 #> TSC2          0.0000000       0.000000       0.000000       0.000000 #>          X57_Y-81..CD4T X58_Y-81..CD4T X56_Y-81..CD4T X54_Y-81..CD4T #> PDK4           0.000000        0.00000       0.000000       0.000000 #> TNFRSF17       0.000000        0.00000       0.000000       0.000000 #> ICAM3          1.786985        2.58012       2.932332       1.421813 #> FAP            0.000000        0.00000       0.000000       0.000000 #> GZMB           0.000000        0.00000       0.000000       0.000000 #> TSC2           0.000000        0.00000       0.000000       0.000000 #>          X59_Y-81..CD4T X60_Y-81..CD4T X58_Y-82..CD4T X55_Y-82..CD4T #> PDK4           0.000000      0.0000000       0.000000       0.000000 #> TNFRSF17       0.000000      0.0000000       0.000000       0.000000 #> ICAM3          2.195498      0.7979814       1.836735       1.439938 #> FAP            0.000000      0.0000000       0.000000       0.000000 #> GZMB           0.000000      0.0000000       0.000000       0.000000 #> TSC2           0.000000      0.0000000       0.000000       0.000000 #>          X57_Y-82..CD4T X56_Y-82..CD4T X59_Y-82..CD4T X54_Y-82..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          1.774773       1.125956       1.340412       2.412132 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X57_Y-83..CD4T X59_Y-83..CD4T X58_Y-83..CD4T X55_Y-83..CD4T #> PDK4           0.000000              0       0.000000       0.000000 #> TNFRSF17       0.000000              0       0.000000       0.000000 #> ICAM3          1.942505              0       3.591599       3.018908 #> FAP            0.000000              0       0.000000       0.000000 #> GZMB           0.000000              0       0.000000       0.000000 #> TSC2           0.000000              0       0.000000       0.000000 #>          X61_Y-83..CD4T X56_Y-83..CD4T X58_Y-84..CD4T X57_Y-84..CD4T #> PDK4           0.000000              0        0.00000      0.0000000 #> TNFRSF17       0.000000              0        0.00000      0.0000000 #> ICAM3          1.754761              0        2.23795      1.8088659 #> FAP            0.000000              0        0.00000      0.0000000 #> GZMB           0.000000              0        0.00000      0.9672564 #> TSC2           0.000000              0        0.00000      0.0000000 #>          X59_Y-84..CD4T X54_Y-84..CD4T X55_Y-84..CD4T X59_Y-85..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          4.142667       4.315649       4.416319       2.091148 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X60_Y-85..CD4T X56_Y-85..CD4T X61_Y-85..CD4T X56_Y-84..CD4T #> PDK4          0.0000000       0.000000       0.000000              0 #> TNFRSF17      0.0000000       0.000000       0.000000              0 #> ICAM3         1.7870027       4.566825       1.754484              0 #> FAP           0.0000000       0.000000       0.000000              0 #> GZMB          0.5732323       0.000000       0.000000              0 #> TSC2          0.0000000       0.000000       0.000000              0 #>          X79_Y-80..CD4T X60_Y-82..CD4T X60_Y-83..CD4T X62_Y-83..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          4.468283       1.584365       1.754761       2.453962 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           4.468283       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X64_Y-84..CD4T X62_Y-84..CD4T X63_Y-84..CD4T X61_Y-84..CD4T #> PDK4          0.0000000       0.000000       0.000000              0 #> TNFRSF17      0.0000000       0.000000       0.000000              0 #> ICAM3         2.6643191       2.102488       2.680496              0 #> FAP           0.0000000       0.000000       0.000000              0 #> GZMB          0.0000000       0.000000       0.000000              0 #> TSC2          0.2671964       0.000000       0.000000              0 #>          X65_Y-84..CD4T X62_Y-85..CD4T X64_Y-85..CD4T X63_Y-85..CD4T #> PDK4          0.0000000      0.0000000       0.000000      0.0000000 #> TNFRSF17      0.0000000      0.0000000       0.000000      0.0000000 #> ICAM3         1.6649262      1.8305633       2.710257      3.0156406 #> FAP           0.0000000      0.0000000       0.000000      0.0000000 #> GZMB          0.2513632      0.9378541       0.000000      0.2732539 #> TSC2          0.0000000      0.0000000       0.000000      0.0000000 #>          X65_Y-85..CD4T X61_Y-80..CD4T X64_Y-83..CD4T X66_Y-85..CD4T #> PDK4          0.0000000              0       0.000000      0.0000000 #> TNFRSF17      0.0000000              0       0.000000      0.0000000 #> ICAM3         1.6595285              0       3.616574      2.4627101 #> FAP           0.0000000              0       0.000000      0.0000000 #> GZMB          0.2513632              0       0.000000      0.2659938 #> TSC2          0.0000000              0       0.000000      0.0000000 #>          X34_Y-91..CD4T X35_Y-91..CD4T X35_Y-93..CD4T X36_Y-94..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          4.703852       1.449386       2.443589       1.745331 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X36_Y-95..CD4T X34_Y-96..CD4T X34_Y-97..CD4T X36_Y-92..CD4T #> PDK4           0.000000       0.000000       0.000000              0 #> TNFRSF17       0.000000       0.000000       0.000000              0 #> ICAM3          4.954735       3.804965       0.000000              0 #> FAP            0.000000       0.000000       0.000000              0 #> GZMB           0.000000       0.000000       4.296792              0 #> TSC2           0.000000       0.000000       0.000000              0 #>          X35_Y-92..CD4T X35_Y-94..CD4T X34_Y-95..CD4T X35_Y-96..CD4T #> PDK4           0.000000              0        0.00000          0.000 #> TNFRSF17       0.000000              0        0.00000          0.000 #> ICAM3          1.449386              0        5.03209          5.011 #> FAP            0.000000              0        0.00000          0.000 #> GZMB           0.000000              0        0.00000          0.000 #> TSC2           0.000000              0        0.00000          0.000 #>          X48_Y-85..CD4T X42_Y-86..CD4T X44_Y-86..CD4T X45_Y-86..CD4T #> PDK4           0.000000       0.000000       0.000000      0.0000000 #> TNFRSF17       0.000000       0.000000       0.000000      0.0000000 #> ICAM3          3.209201       1.434655       2.140443      2.6436466 #> FAP            0.000000       0.000000       0.000000      0.0000000 #> GZMB           0.000000       0.000000       0.000000      0.0000000 #> TSC2           0.000000       0.000000       0.463297      0.4641407 #>          X45_Y-87..CD4T X44_Y-87..CD4T X42_Y-87..CD4T X47_Y-87..CD4T #> PDK4          0.0000000      0.0000000       0.000000      0.0000000 #> TNFRSF17      0.0000000      0.0000000       0.000000      0.0000000 #> ICAM3         2.6593864      4.8167270       2.388077      1.8179846 #> FAP           0.0000000      0.0000000       0.000000      0.0000000 #> GZMB          0.0000000      0.0000000       0.000000      0.0000000 #> TSC2          0.5346431      0.9623575       0.000000      0.8289816 #>          X46_Y-87..CD4T X42_Y-88..CD4T X45_Y-88..CD4T X46_Y-88..CD4T #> PDK4          0.0000000       0.000000       0.000000      0.0000000 #> TNFRSF17      0.0000000       0.000000       0.000000      0.0000000 #> ICAM3         1.8149937       4.918402       1.121785      2.7419189 #> FAP           0.0000000       0.000000       0.000000      0.0000000 #> GZMB          0.8666407       0.000000       0.000000      0.3611003 #> TSC2          0.0000000       0.000000       0.000000      0.0000000 #>          X44_Y-88..CD4T X47_Y-88..CD4T X43_Y-88..CD4T X45_Y-89..CD4T #> PDK4           0.000000       0.000000       0.000000      0.0000000 #> TNFRSF17       0.000000       0.000000       0.000000      0.0000000 #> ICAM3          3.807113       2.173297       4.635125      2.6109039 #> FAP            0.000000       0.000000       0.000000      0.0000000 #> GZMB           0.000000       0.000000       0.000000      0.2519177 #> TSC2           0.000000       0.000000       0.000000      0.2519177 #>          X44_Y-89..CD4T X47_Y-89..CD4T X48_Y-89..CD4T X46_Y-89..CD4T #> PDK4           0.000000      0.0000000      0.0000000      0.0000000 #> TNFRSF17       0.000000      0.0000000      0.0000000      0.0000000 #> ICAM3          3.544828      1.6576712      2.3091069      2.1872385 #> FAP            0.000000      0.0000000      0.0000000      0.0000000 #> GZMB           0.000000      0.0000000      0.0000000      0.2009494 #> TSC2           0.000000      0.1946694      0.6432827      0.0000000 #>          X47_Y-90..CD4T X44_Y-90..CD4T X46_Y-90..CD4T X48_Y-90..CD4T #> PDK4          0.0000000       0.000000      0.0000000      0.0000000 #> TNFRSF17      0.0000000       0.000000      0.0000000      0.0000000 #> ICAM3         2.1259014       2.409164      2.0598530      2.8546606 #> FAP           0.0000000       0.000000      0.0000000      0.0000000 #> GZMB          0.2511868       0.000000      0.2232772      0.0000000 #> TSC2          0.2433368       0.000000      0.2165617      0.4093617 #>          X43_Y-90..CD4T X45_Y-90..CD4T X42_Y-90..CD4T X42_Y-91..CD4T #> PDK4           0.000000      0.0000000       0.000000       0.000000 #> TNFRSF17       0.000000      0.0000000       0.000000       0.000000 #> ICAM3          3.436736      2.6941335       3.139337       4.108909 #> FAP            0.000000      0.0000000       0.000000       0.000000 #> GZMB           0.000000      0.2141300       0.000000       0.000000 #> TSC2           0.000000      0.4090356       0.000000       0.000000 #>          X45_Y-85..CD4T X48_Y-86..CD4T X43_Y-86..CD4T X51_Y-79..CD4T #> PDK4           0.000000       0.000000       0.000000      0.0000000 #> TNFRSF17       0.000000       0.000000       0.000000      0.0000000 #> ICAM3          3.544599       3.595174       3.495159      2.2785529 #> FAP            0.000000       0.000000       0.000000      0.0000000 #> GZMB           0.000000       0.000000       0.000000      0.6027839 #> TSC2           0.729364       0.000000       1.389891      0.2883874 #>          X53_Y-80..CD4T X51_Y-80..CD4T X52_Y-80..CD4T X49_Y-80..CD4T #> PDK4           0.000000      0.0000000       0.000000      0.0000000 #> TNFRSF17       0.000000      0.0000000       0.000000      0.0000000 #> ICAM3          2.508922      3.3834226       3.310062      2.8229007 #> FAP            0.000000      0.0000000       0.000000      0.0000000 #> GZMB           0.000000      0.2694496       0.000000      0.0000000 #> TSC2           0.000000      0.2703632       0.000000      0.2370883 #>          X50_Y-80..CD4T X50_Y-81..CD4T X53_Y-81..CD4T X51_Y-81..CD4T #> PDK4          0.0000000       0.000000       0.000000       0.000000 #> TNFRSF17      0.0000000       0.000000       0.000000       0.000000 #> ICAM3         2.4216931       3.415864       2.703015       1.973869 #> FAP           0.0000000       0.000000       0.000000       0.000000 #> GZMB          0.4754153       0.000000       0.000000       0.000000 #> TSC2          0.2370883       0.000000       0.000000       0.000000 #>          X52_Y-81..CD4T X51_Y-82..CD4T X50_Y-82..CD4T X51_Y-83..CD4T #> PDK4           0.000000       0.000000      0.0000000       0.000000 #> TNFRSF17       0.000000       0.000000      0.0000000       0.000000 #> ICAM3          2.766248       1.012956      0.5628724       1.439154 #> FAP            0.000000       0.000000      0.0000000       0.000000 #> GZMB           0.000000       0.000000      0.0000000       0.000000 #> TSC2           0.000000       0.000000      0.0000000       0.000000 #>          X52_Y-83..CD4T X54_Y-83..CD4T X52_Y-84..CD4T X54_Y-85..CD4T #> PDK4          0.0000000        0.00000      0.0000000       0.000000 #> TNFRSF17      0.0000000        0.00000      0.0000000       0.000000 #> ICAM3         3.3682339        3.25856      3.8125185       3.396151 #> FAP           0.0000000        0.00000      0.0000000       0.000000 #> GZMB          0.5387513        0.00000      0.0000000       0.000000 #> TSC2          0.0000000        0.00000      0.7140395       0.000000 #>          X52_Y-85..CD4T X53_Y-82..CD4T X51_Y-84..CD4T X48_Y-84..CD4T #> PDK4           0.000000       0.000000      0.0000000       0.000000 #> TNFRSF17       0.000000       0.000000      0.0000000       0.000000 #> ICAM3          2.580749       2.429512      1.8211110       5.184671 #> FAP            0.000000       0.000000      0.0000000       0.000000 #> GZMB           0.000000       0.000000      0.0000000       0.000000 #> TSC2           0.000000       0.000000      0.5858747       0.000000 #>          X70_Y-91..CD4T X69_Y-92..CD4T X73_Y-93..CD4T X68_Y-94..CD4T #> PDK4                  0       0.000000       0.000000              0 #> TNFRSF17              0       0.000000       0.000000              0 #> ICAM3                 0       5.283602       5.346428              0 #> FAP                   0       0.000000       0.000000              0 #> GZMB                  0       5.283602       0.000000              0 #> TSC2                  0       0.000000       0.000000              0 #>          X66_Y-96..CD4T X73_Y-97..CD4T X70_Y-92..CD4T X69_Y-94..CD4T #> PDK4           0.000000              0       0.000000       0.000000 #> TNFRSF17       0.000000              0       0.000000       0.000000 #> ICAM3          4.686998              0       2.544693       0.000000 #> FAP            0.000000              0       0.000000       0.000000 #> GZMB           0.000000              0       0.000000       5.264283 #> TSC2           0.000000              0       0.000000       0.000000 #>          X78_Y-92..CD4T X76_Y-92..CD4T X76_Y-93..CD4T X75_Y-93..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          4.968234       4.517478       4.669328       4.867351 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X77_Y-93..CD4T X78_Y-94..CD4T X77_Y-94..CD4T X76_Y-94..CD4T #> PDK4           0.000000              0       0.000000        0.00000 #> TNFRSF17       0.000000              0       0.000000        0.00000 #> ICAM3          4.889067              0       2.414025        2.31714 #> FAP            0.000000              0       0.000000        0.00000 #> GZMB           0.000000              0       0.000000        0.00000 #> TSC2           0.000000              0       0.000000        0.00000 #>          X75_Y-94..CD4T X78_Y-95..CD4T X72_Y-95..CD4T X77_Y-95..CD4T #> PDK4           0.000000       0.000000              0       0.000000 #> TNFRSF17       0.000000       0.000000              0       0.000000 #> ICAM3          3.931826       1.789709              0       2.950113 #> FAP            0.000000       0.000000              0       0.000000 #> GZMB           0.000000       0.000000              0       0.000000 #> TSC2           0.000000       0.000000              0       0.000000 #>          X76_Y-95..CD4T X78_Y-96..CD4T X75_Y-96..CD4T X76_Y-96..CD4T #> PDK4                  0        0.00000       0.000000       0.000000 #> TNFRSF17              0        0.00000       0.000000       0.000000 #> ICAM3                 0        4.76277       5.027264       2.348855 #> FAP                   0        0.00000       0.000000       0.000000 #> GZMB                  0        0.00000       5.027264       0.000000 #> TSC2                  0        0.00000       0.000000       0.000000 #>          X78_Y-97..CD4T X75_Y-97..CD4T X74_Y-93..CD4T X74_Y-95..CD4T #> PDK4           0.000000       0.000000       0.000000              0 #> TNFRSF17       0.000000       0.000000       0.000000              0 #> ICAM3          4.912057       4.647939       4.973788              0 #> FAP            0.000000       0.000000       0.000000              0 #> GZMB           0.000000       2.513632       0.000000              0 #> TSC2           0.000000       0.000000       0.000000              0 #>          X73_Y-95..CD4T X42_Y-67..CD4T X46_Y-67..CD4T X46_Y-68..CD4T #> PDK4                  0              0       0.000000       0.000000 #> TNFRSF17              0              0       0.000000       0.000000 #> ICAM3                 0              0       2.783545       3.151365 #> FAP                   0              0       0.000000       0.000000 #> GZMB                  0              0       0.000000       0.000000 #> TSC2                  0              0       0.000000       0.000000 #>          X47_Y-69..CD4T X47_Y-70..CD4T X44_Y-70..CD4T X47_Y-71..CD4T #> PDK4                  0      0.0000000              0        0.00000 #> TNFRSF17              0      0.0000000              0        0.00000 #> ICAM3                 0      0.8788898              0        1.34122 #> FAP                   0      0.0000000              0        0.00000 #> GZMB                  0      0.0000000              0        0.00000 #> TSC2                  0      0.0000000              0        0.00000 #>          X46_Y-71..CD4T X46_Y-69..CD4T X73_Y-65..CD4T X79_Y-65..CD4T #> PDK4           0.000000       0.000000       0.000000              0 #> TNFRSF17       0.000000       0.000000       0.000000              0 #> ICAM3          2.682441       2.127412       2.520053              0 #> FAP            0.000000       0.000000       0.000000              0 #> GZMB           0.000000       0.000000       0.000000              0 #> TSC2           0.000000       0.000000       0.000000              0 #>          X74_Y-65..CD4T X75_Y-66..CD4T X26_Y-89..CD4T X27_Y-90..CD4T #> PDK4           0.000000      0.0000000        0.00000       0.000000 #> TNFRSF17       0.000000      0.0000000        0.00000       0.000000 #> ICAM3          2.183745      2.6855557        3.94168       3.208036 #> FAP            0.000000      0.0000000        0.00000       0.000000 #> GZMB           0.000000      0.5207775        0.00000       0.000000 #> TSC2           0.000000      0.0000000        0.00000       0.000000 #>          X35_Y-86..CD4T X36_Y-88..CD4T X34_Y-90..CD4T X33_Y-91..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          4.050084       4.843472       2.996526       3.400714 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X34_Y-86..CD4T X41_Y-85..CD4T X41_Y-88..CD4T X35_Y-88..CD4T #> PDK4                  0              0       0.000000       0.000000 #> TNFRSF17              0              0       0.000000       0.000000 #> ICAM3                 0              0       4.268613       4.843472 #> FAP                   0              0       0.000000       0.000000 #> GZMB                  0              0       0.000000       0.000000 #> TSC2                  0              0       0.000000       0.000000 #>          X36_Y-89..CD4T X42_Y-89..CD4T X37_Y-90..CD4T X36_Y-90..CD4T #> PDK4                  0        0.00000       0.000000       0.000000 #> TNFRSF17              0        0.00000       0.000000       0.000000 #> ICAM3                 0        3.60346       4.214594       4.374893 #> FAP                   0        0.00000       0.000000       0.000000 #> GZMB                  0        0.00000       0.000000       0.000000 #> TSC2                  0        0.00000       0.000000       0.000000 #>          X32_Y-100..CD4T X30_Y-101..CD4T X31_Y-101..CD4T X30_Y-102..CD4T #> PDK4                   0        0.000000        0.000000        0.000000 #> TNFRSF17               0        0.000000        0.000000        0.000000 #> ICAM3                  0        3.958885        3.721509        3.906175 #> FAP                    0        0.000000        0.000000        0.000000 #> GZMB                   0        0.000000        0.000000        0.000000 #> TSC2                   0        0.000000        0.000000        0.000000 #>          X31_Y-102..CD4T X30_Y-103..CD4T X31_Y-103..CD4T X33_Y-103..CD4T #> PDK4              0.0000        0.000000        0.000000        0.000000 #> TNFRSF17          0.0000        0.000000        0.000000        0.000000 #> ICAM3             3.0761        2.923697        3.491006        2.916626 #> FAP               0.0000        0.000000        0.000000        0.000000 #> GZMB              0.0000        0.000000        0.000000        0.000000 #> TSC2              0.0000        0.000000        0.000000        0.000000 #>          X32_Y-103..CD4T X34_Y-100..CD4T X32_Y-104..CD4T X22_Y-87..CD4T #> PDK4            0.000000               0        0.000000              0 #> TNFRSF17        0.000000               0        0.000000              0 #> ICAM3           3.496819               0        3.193353              0 #> FAP             0.000000               0        0.000000              0 #> GZMB            0.000000               0        0.000000              0 #> TSC2            0.000000               0        0.000000              0 #>          X22_Y-91..CD4T X23_Y-86..CD4T X22_Y-99..CD4T X22_Y-103..CD4T #> PDK4                  0       0.000000       0.000000               0 #> TNFRSF17              0       0.000000       0.000000               0 #> ICAM3                 0       4.728857       5.262747               0 #> FAP                   0       0.000000       0.000000               0 #> GZMB                  0       0.000000       0.000000               0 #> TSC2                  0       0.000000       0.000000               0 #>          X23_Y-99..CD4T X25_Y-97..CD4T X28_Y-101..CD4T X27_Y-101..CD4T #> PDK4           0.000000       0.000000        0.000000        0.000000 #> TNFRSF17       0.000000       0.000000        0.000000        0.000000 #> ICAM3          2.595287       5.000537        3.230825        2.747486 #> FAP            0.000000       0.000000        0.000000        0.000000 #> GZMB           0.000000       1.624735        0.000000        0.000000 #> TSC2           0.000000       0.000000        0.000000        0.000000 #>          X29_Y-102..CD4T X27_Y-102..CD4T X28_Y-102..CD4T X26_Y-102..CD4T #> PDK4            0.000000         0.00000        0.000000        0.000000 #> TNFRSF17        0.000000         0.00000        0.000000        0.000000 #> ICAM3           1.569513         5.51308        3.175088        4.502979 #> FAP             0.000000         0.00000        0.000000        0.000000 #> GZMB            0.000000         0.00000        0.000000        0.000000 #> TSC2            0.000000         0.00000        0.000000        0.000000 #>          X28_Y-103..CD4T X25_Y-103..CD4T X24_Y-97..CD4T X29_Y-101..CD4T #> PDK4            0.000000        0.000000       0.000000        0.000000 #> TNFRSF17        0.000000        0.000000       0.000000        0.000000 #> ICAM3           4.588412        5.159809       5.125618        3.558484 #> FAP             0.000000        0.000000       0.000000        0.000000 #> GZMB            0.000000        0.000000       1.218551        0.000000 #> TSC2            0.000000        0.000000       0.000000        0.000000 #>          X74_Y-104..CD4T X77_Y-104..CD4T X74_Y-105..CD4T X73_Y-105..CD4T #> PDK4           0.0000000        0.000000       0.0000000        0.000000 #> TNFRSF17       0.0000000        0.000000       0.0000000        0.000000 #> ICAM3          0.9438981        2.376547       0.6742129        3.492406 #> FAP            0.0000000        0.000000       0.0000000        0.000000 #> GZMB           0.9483530        0.000000       1.4350100        0.000000 #> TSC2           0.0000000        0.000000       0.0000000        0.000000 #>          X75_Y-106..CD4T X73_Y-106..CD4T X74_Y-106..CD4T X75_Y-104..CD4T #> PDK4           0.0000000        0.000000        0.000000        0.000000 #> TNFRSF17       0.0000000        0.000000        0.000000        0.000000 #> ICAM3          0.9904241        3.617353        0.000000        4.996693 #> FAP            0.0000000        0.000000        0.000000        0.000000 #> GZMB           0.0000000        1.742247        1.742247        2.292929 #> TSC2           0.0000000        0.000000        0.000000        0.000000 #>          X73_Y-107..CD4T X62_Y-98..CD4T X63_Y-98..CD4T X60_Y-99..CD4T #> PDK4            0.000000       0.000000       0.000000       0.000000 #> TNFRSF17        0.000000       0.000000       0.000000       0.000000 #> ICAM3           0.000000       3.726855       4.887178       3.252285 #> FAP             0.000000       0.000000       0.000000       0.000000 #> GZMB            2.613371       0.000000       0.000000       0.000000 #> TSC2            0.000000       0.000000       0.000000       0.000000 #>          X65_Y-99..CD4T X62_Y-99..CD4T X61_Y-99..CD4T X63_Y-99..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.491555       1.218551       4.037312       5.880932 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X62_Y-100..CD4T X63_Y-100..CD4T X61_Y-100..CD4T X64_Y-100..CD4T #> PDK4            0.000000        0.000000        0.000000        0.000000 #> TNFRSF17        0.000000        0.000000        0.000000        0.000000 #> ICAM3           1.792362        2.580652        2.437103        2.557047 #> FAP             0.000000        0.000000        0.000000        0.000000 #> GZMB            0.000000        0.000000        0.000000        1.202947 #> TSC2            0.000000        0.000000        0.000000        0.000000 #>          X63_Y-101..CD4T X61_Y-101..CD4T X64_Y-101..CD4T X65_Y-101..CD4T #> PDK4                   0       0.0000000       0.0000000       0.0000000 #> TNFRSF17               0       0.0000000       0.0000000       0.0000000 #> ICAM3                  0       2.3459957       2.0478949       2.9481690 #> FAP                    0       0.0000000       0.0000000       0.0000000 #> GZMB                   0       0.5251932       0.6873982       0.9623575 #> TSC2                   0       0.0000000       0.0000000       0.0000000 #>          X62_Y-101..CD4T X66_Y-101..CD4T X64_Y-102..CD4T X62_Y-102..CD4T #> PDK4            0.000000        0.000000       0.0000000        0.000000 #> TNFRSF17        0.000000        0.000000       0.0000000        0.000000 #> ICAM3           3.756285        3.147809       0.6823076        3.138058 #> FAP             0.000000        0.000000       0.0000000        0.000000 #> GZMB            0.000000        0.000000       0.0000000        0.000000 #> TSC2            0.000000        0.000000       0.0000000        0.000000 #>          X66_Y-102..CD4T X61_Y-102..CD4T X60_Y-102..CD4T X64_Y-103..CD4T #> PDK4            0.000000        0.000000        0.000000        0.000000 #> TNFRSF17        0.000000        0.000000        0.000000        0.000000 #> ICAM3           1.065424        2.867496        2.470449        1.955021 #> FAP             0.000000        0.000000        0.000000        0.000000 #> GZMB            0.000000        0.000000        0.000000        0.537099 #> TSC2            0.000000        0.000000        0.000000        0.537099 #>          X63_Y-103..CD4T X65_Y-103..CD4T X62_Y-103..CD4T X61_Y-103..CD4T #> PDK4           0.0000000        0.000000        0.000000        0.000000 #> TNFRSF17       0.0000000        0.000000        0.000000        0.000000 #> ICAM3          3.4687772        2.332959        1.773293        3.760403 #> FAP            0.0000000        0.000000        0.000000        0.000000 #> GZMB           0.2417005        0.000000        0.000000        0.000000 #> TSC2           0.0000000        0.000000        0.000000        0.000000 #>          X63_Y-104..CD4T X61_Y-104..CD4T X63_Y-102..CD4T X64_Y-104..CD4T #> PDK4           0.0000000        0.000000       0.0000000       0.0000000 #> TNFRSF17       0.0000000        0.000000       0.0000000       0.0000000 #> ICAM3          1.8253908        1.308999       2.3709545       2.6759811 #> FAP            0.0000000        0.000000       0.0000000       0.0000000 #> GZMB           0.4296792        0.000000       0.6848181       0.3305225 #> TSC2           0.4296792        0.000000       0.0000000       0.3305225 #>          X23_Y-104..CD4T X23_Y-106..CD4T X24_Y-106..CD4T X22_Y-106..CD4T #> PDK4            0.000000        0.000000        0.000000        0.000000 #> TNFRSF17        0.000000        0.000000        0.000000        0.000000 #> ICAM3           4.062903        3.155227        3.953971        2.521216 #> FAP             0.000000        0.000000        0.000000        0.000000 #> GZMB            0.000000        0.000000        0.000000        0.000000 #> TSC2            0.000000        0.000000        0.000000        0.000000 #>          X21_Y-106..CD4T X22_Y-107..CD4T X69_Y-86..CD4T X70_Y-86..CD4T #> PDK4            0.000000        0.000000      0.0000000      0.0000000 #> TNFRSF17        0.000000        0.000000      0.0000000      0.0000000 #> ICAM3           3.323195        3.323195      3.9633981      3.4416295 #> FAP             0.000000        0.000000      0.0000000      0.0000000 #> GZMB            0.000000        0.000000      0.2217389      0.0000000 #> TSC2            0.000000        0.000000      0.2217389      0.2750825 #>          X68_Y-86..CD4T X67_Y-86..CD4T X71_Y-86..CD4T X68_Y-87..CD4T #> PDK4           0.000000      0.0000000        0.00000       0.000000 #> TNFRSF17       0.000000      0.0000000        0.00000       0.000000 #> ICAM3          2.329445      2.8112394        4.97356       3.782066 #> FAP            0.000000      0.0000000        0.00000       0.000000 #> GZMB           0.000000      0.0000000        0.00000       0.000000 #> TSC2           0.000000      0.2189387        0.00000       0.000000 #>          X69_Y-87..CD4T X70_Y-87..CD4T X68_Y-88..CD4T X69_Y-88..CD4T #> PDK4            0.00000              0       0.000000       0.000000 #> TNFRSF17        0.00000              0       0.000000       0.000000 #> ICAM3           3.07888              0       2.383524       2.402839 #> FAP             0.00000              0       0.000000       0.000000 #> GZMB            0.00000              0       0.000000       0.000000 #> TSC2            0.00000              0       0.000000       0.000000 #>          X72_Y-88..CD4T X71_Y-88..CD4T X71_Y-89..CD4T X68_Y-89..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          1.322255       1.322255       4.585859       2.329692 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X68_Y-90..CD4T X66_Y-86..CD4T X67_Y-87..CD4T X25_Y-104..CD4T #> PDK4           0.000000      0.0000000      0.0000000        0.000000 #> TNFRSF17       0.000000      0.0000000      0.0000000        0.000000 #> ICAM3          1.646949      2.3523015      4.0719090        5.159809 #> FAP            0.000000      0.0000000      0.0000000        0.000000 #> GZMB           0.000000      0.2519941      0.8189413        0.000000 #> TSC2           0.000000      0.0000000      0.0000000        0.000000 #>          X29_Y-104..CD4T X28_Y-105..CD4T X23_Y-105..CD4T X25_Y-105..CD4T #> PDK4                   0        0.000000        0.000000        0.000000 #> TNFRSF17               0        0.000000        0.000000        0.000000 #> ICAM3                  0        4.787888        4.182296        4.637509 #> FAP                    0        0.000000        0.000000        0.000000 #> GZMB                   0        0.000000        0.000000        1.387807 #> TSC2                   0        0.000000        0.000000        0.000000 #>          X24_Y-105..CD4T X25_Y-106..CD4T X26_Y-106..CD4T X26_Y-107..CD4T #> PDK4            0.000000        0.000000        0.000000       0.0000000 #> TNFRSF17        0.000000        0.000000        0.000000       0.0000000 #> ICAM3           4.520879        3.760926        4.012792       3.9444343 #> FAP             0.000000        0.000000        0.000000       0.0000000 #> GZMB            0.000000        1.498920        0.000000       0.9660202 #> TSC2            0.000000        0.000000        1.083301       0.8666407 #>          X25_Y-107..CD4T X27_Y-107..CD4T X24_Y-107..CD4T X27_Y-106..CD4T #> PDK4           0.0000000        0.000000        0.000000        0.000000 #> TNFRSF17       0.0000000        0.000000        0.000000        0.000000 #> ICAM3          3.7570790        5.634209        5.181734        5.747799 #> FAP            0.0000000        0.000000        0.000000        0.000000 #> GZMB           0.9660202        0.000000        0.000000        0.000000 #> TSC2           0.0000000        0.000000        0.000000        0.000000 #>          X69_Y-98..CD4T X72_Y-98..CD4T X67_Y-98..CD4T X69_Y-100..CD4T #> PDK4                  0       0.000000              0               0 #> TNFRSF17              0       0.000000              0               0 #> ICAM3                 0       2.376547              0               0 #> FAP                   0       0.000000              0               0 #> GZMB                  0       2.622667              0               0 #> TSC2                  0       0.000000              0               0 #>          X72_Y-102..CD4T X69_Y-102..CD4T X70_Y-102..CD4T X67_Y-103..CD4T #> PDK4            0.000000               0               0        0.000000 #> TNFRSF17        0.000000               0               0        0.000000 #> ICAM3           1.663444               0               0        0.000000 #> FAP             0.000000               0               0        0.000000 #> GZMB            0.000000               0               0        4.635125 #> TSC2            1.429890               0               0        0.000000 #>          X68_Y-103..CD4T X70_Y-99..CD4T X72_Y-100..CD4T X67_Y-102..CD4T #> PDK4            0.000000       0.000000               0        0.000000 #> TNFRSF17        0.000000       0.000000               0        0.000000 #> ICAM3           5.323408       2.569343               0        2.278723 #> FAP             0.000000       0.000000               0        0.000000 #> GZMB            0.000000       0.000000               0        0.000000 #> TSC2            0.000000       0.000000               0        0.000000 #>          X70_Y-104..CD4T X72_Y-104..CD4T X71_Y-104..CD4T X69_Y-104..CD4T #> PDK4            0.000000        0.000000       0.0000000        0.000000 #> TNFRSF17        0.000000        0.000000       0.0000000        0.000000 #> ICAM3           2.934486        2.788274       3.8040771        5.057837 #> FAP             0.000000        0.000000       0.0000000        0.000000 #> GZMB            0.000000        0.000000       0.0000000        0.000000 #> TSC2            0.000000        0.000000       0.9414259        0.000000 #>          X70_Y-105..CD4T X67_Y-105..CD4T X68_Y-105..CD4T X71_Y-105..CD4T #> PDK4            0.000000        0.000000        0.000000       0.0000000 #> TNFRSF17        0.000000        0.000000        0.000000       0.0000000 #> ICAM3           3.334977        2.980975        0.000000       4.0564592 #> FAP             0.000000        0.000000        0.000000       0.0000000 #> GZMB            0.000000        0.000000        2.221523       0.0000000 #> TSC2            0.000000        0.000000        0.000000       0.6276173 #>          X69_Y-105..CD4T X67_Y-106..CD4T X70_Y-106..CD4T X68_Y-106..CD4T #> PDK4            0.000000       0.0000000        0.000000        0.000000 #> TNFRSF17        0.000000       0.0000000        0.000000        0.000000 #> ICAM3           4.576296       0.7742138        1.363358        1.008486 #> FAP             0.000000       0.0000000        0.000000        0.000000 #> GZMB            0.000000       0.8959212        1.536109        0.000000 #> TSC2            0.000000       0.0000000        0.000000        0.000000 #>          X66_Y-106..CD4T X71_Y-106..CD4T X69_Y-107..CD4T X71_Y-107..CD4T #> PDK4            0.000000        0.000000        0.000000               0 #> TNFRSF17        0.000000        0.000000        0.000000               0 #> ICAM3           1.225081        2.054454        3.711592               0 #> FAP             0.000000        0.000000        0.000000               0 #> GZMB            1.153780        0.000000        0.000000               0 #> TSC2            0.000000        0.000000        0.000000               0 #>          X70_Y-107..CD4T X68_Y-107..CD4T X67_Y-104..CD4T X72_Y-105..CD4T #> PDK4            0.000000               0       0.0000000        0.000000 #> TNFRSF17        0.000000               0       0.0000000        0.000000 #> ICAM3           2.639745               0       1.8521631        5.630415 #> FAP             0.000000               0       0.0000000        0.000000 #> GZMB            1.536109               0       0.9210538        0.000000 #> TSC2            0.000000               0       0.0000000        0.000000 #>          X56_Y-103..CD4T X57_Y-104..CD4T X56_Y-104..CD4T X58_Y-104..CD4T #> PDK4            0.000000       0.0000000        0.000000       0.0000000 #> TNFRSF17        0.000000       0.0000000        0.000000       0.0000000 #> ICAM3           3.023332       0.9121775        1.049984       2.8893089 #> FAP             0.000000       0.0000000        0.000000       0.0000000 #> GZMB            0.000000       0.0000000        0.000000       0.5515678 #> TSC2            0.000000       0.0000000        0.000000       0.0000000 #>          X58_Y-105..CD4T X61_Y-105..CD4T X59_Y-105..CD4T X55_Y-105..CD4T #> PDK4            0.000000        0.000000        0.000000       0.0000000 #> TNFRSF17        0.000000        0.000000        0.000000       0.0000000 #> ICAM3           2.084964        1.492281        1.139361       1.9106391 #> FAP             0.000000        0.000000        0.000000       0.0000000 #> GZMB            0.000000        0.000000        0.000000       0.0000000 #> TSC2            0.000000        0.000000        0.000000       0.5379958 #>          X56_Y-105..CD4T X54_Y-105..CD4T X57_Y-106..CD4T X59_Y-106..CD4T #> PDK4            0.000000        0.000000          0.0000               0 #> TNFRSF17        0.000000        0.000000          0.0000               0 #> ICAM3           2.937144        4.543291          1.8411               0 #> FAP             0.000000        0.000000          0.0000               0 #> GZMB            0.000000        0.000000          0.0000               0 #> TSC2            0.000000        0.000000          0.0000               0 #>          X59_Y-103..CD4T X55_Y-104..CD4T X57_Y-105..CD4T X56_Y-106..CD4T #> PDK4            0.000000        0.000000         0.00000        0.000000 #> TNFRSF17        0.000000        0.000000         0.00000        0.000000 #> ICAM3           2.451002        5.278628         1.79181        2.686189 #> FAP             0.000000        0.000000         0.00000        0.000000 #> GZMB            0.000000        0.000000         0.00000        0.000000 #> TSC2            0.000000        0.000000         0.00000        0.000000 #>          X55_Y-107..CD4T X65_Y-104..CD4T X64_Y-105..CD4T X65_Y-105..CD4T #> PDK4            0.000000       0.0000000        0.000000       0.0000000 #> TNFRSF17        0.000000       0.0000000        0.000000       0.0000000 #> ICAM3           2.103244       4.1044725        2.276021       2.8716802 #> FAP             0.000000       0.0000000        0.000000       0.0000000 #> GZMB            0.949815       0.0000000        0.000000       0.0000000 #> TSC2            0.000000       0.3648978        0.000000       0.4378773 #>          X66_Y-105..CD4T X63_Y-105..CD4T X64_Y-106..CD4T X63_Y-106..CD4T #> PDK4           0.0000000        0.000000         0.00000        0.000000 #> TNFRSF17       0.0000000        0.000000         0.00000        0.000000 #> ICAM3          2.0781384        2.227338         2.18553        2.089267 #> FAP            0.0000000        0.000000         0.00000        0.000000 #> GZMB           0.6593029        0.000000         0.00000        0.000000 #> TSC2           0.0000000        0.000000         0.00000        0.000000 #>          X65_Y-106..CD4T X64_Y-107..CD4T X65_Y-107..CD4T X49_Y-103..CD4T #> PDK4                   0         0.00000       0.0000000       0.0000000 #> TNFRSF17               0         0.00000       0.0000000       0.0000000 #> ICAM3                  0         1.30471       0.6856808       1.9409339 #> FAP                    0         0.00000       0.0000000       0.0000000 #> GZMB                   0         0.00000       0.0000000       0.7740249 #> TSC2                   0         0.00000       0.0000000       0.0000000 #>          X50_Y-104..CD4T X49_Y-104..CD4T X53_Y-104..CD4T X52_Y-104..CD4T #> PDK4            0.000000        0.000000         0.00000         0.00000 #> TNFRSF17        0.000000        0.000000         0.00000         0.00000 #> ICAM3           5.130296        2.505804         3.66332         2.91337 #> FAP             0.000000        0.000000         0.00000         0.00000 #> GZMB            0.000000        0.000000         0.00000         0.00000 #> TSC2            0.000000        0.000000         0.00000         0.00000 #>          X52_Y-105..CD4T X49_Y-106..CD4T X53_Y-106..CD4T X50_Y-106..CD4T #> PDK4            0.000000        0.000000        0.000000               0 #> TNFRSF17        0.000000        0.000000        0.000000               0 #> ICAM3           2.670201        4.601027        2.297758               0 #> FAP             0.000000        0.000000        0.000000               0 #> GZMB            0.000000        0.000000        0.000000               0 #> TSC2            0.000000        0.000000        0.000000               0 #>          X48_Y-106..CD4T X54_Y-107..CD4T X53_Y-107..CD4T X48_Y-107..CD4T #> PDK4            0.000000        0.000000        0.000000               0 #> TNFRSF17        0.000000        0.000000        0.000000               0 #> ICAM3           1.592051        2.359745        2.247271               0 #> FAP             0.000000        0.000000        0.000000               0 #> GZMB            0.000000        0.000000        0.000000               0 #> TSC2            0.000000        0.000000        0.000000               0 #>          X52_Y-107..CD4T X51_Y-107..CD4T X53_Y-105..CD4T X49_Y-105..CD4T #> PDK4            0.000000               0        0.000000        0.000000 #> TNFRSF17        0.000000               0        0.000000        0.000000 #> ICAM3           4.062903               0        2.803089        4.529834 #> FAP             0.000000               0        0.000000        0.000000 #> GZMB            0.000000               0        0.000000        0.000000 #> TSC2            0.000000               0        0.000000        0.000000 #>          X51_Y-106..CD4T X50_Y-107..CD4T X33_Y-104..CD4T X34_Y-104..CD4T #> PDK4            0.000000          0.0000        0.000000        0.000000 #> TNFRSF17        0.000000          0.0000        0.000000        0.000000 #> ICAM3           5.537982          4.5208        5.421048        3.613134 #> FAP             0.000000          0.0000        0.000000        0.000000 #> GZMB            0.000000          0.0000        0.000000        0.000000 #> TSC2            0.000000          0.0000        0.000000        0.000000 #>          X35_Y-104..CD4T X31_Y-104..CD4T X33_Y-105..CD4T X30_Y-107..CD4T #> PDK4             0.00000         0.00000        0.000000               0 #> TNFRSF17         0.00000         0.00000        0.000000               0 #> ICAM3            5.08532         5.44192        4.625072               0 #> FAP              0.00000         0.00000        0.000000               0 #> GZMB             0.00000         0.00000        0.000000               0 #> TSC2             0.00000         0.00000        0.000000               0 #>          X48_Y-105..CD4T X43_Y-105..CD4T X46_Y-106..CD4T X47_Y-106..CD4T #> PDK4           0.0000000        0.000000        0.000000        0.000000 #> TNFRSF17       0.0000000        0.000000        0.000000        0.000000 #> ICAM3          3.8152068        4.472554        3.306266        1.139361 #> FAP            0.0000000        0.000000        0.000000        0.000000 #> GZMB           0.0000000        0.000000        0.000000        0.000000 #> TSC2           0.9188316        0.000000        0.000000        0.000000 #>          X45_Y-107..CD4T X47_Y-107..CD4T X45_Y-106..CD4T X46_Y-107..CD4T #> PDK4            0.000000        0.000000        0.000000          0.0000 #> TNFRSF17        0.000000        0.000000        0.000000          0.0000 #> ICAM3           2.880533        3.123078        2.430701          4.3208 #> FAP             0.000000        0.000000        0.000000          0.0000 #> GZMB            0.000000        0.000000        0.000000          0.0000 #> TSC2            0.000000        0.000000        0.000000          0.0000 #>          X58_Y-98..CD4T X57_Y-98..CD4T X60_Y-98..CD4T X59_Y-98..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          3.446558       1.719406       3.800008       3.659112 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X55_Y-98..CD4T X58_Y-99..CD4T X55_Y-99..CD4T X57_Y-99..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.393989       2.770611       1.569541       1.196972 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.537189       0.000000       0.000000       0.000000 #>          X54_Y-99..CD4T X59_Y-99..CD4T X55_Y-100..CD4T X59_Y-100..CD4T #> PDK4           0.000000       0.000000        0.000000        0.000000 #> TNFRSF17       0.000000       0.000000        0.000000        0.000000 #> ICAM3          1.424685       2.630875        3.497614        4.031577 #> FAP            0.000000       0.000000        0.000000        0.000000 #> GZMB           0.000000       0.000000        0.000000        0.000000 #> TSC2           0.000000       0.000000        0.000000        0.000000 #>          X57_Y-100..CD4T X58_Y-100..CD4T X60_Y-100..CD4T X59_Y-101..CD4T #> PDK4            0.000000        0.000000        0.000000        0.000000 #> TNFRSF17        0.000000        0.000000        0.000000        0.000000 #> ICAM3           4.776417        4.846483        5.026725        4.222276 #> FAP             0.000000        0.000000        0.000000        0.000000 #> GZMB            0.000000        0.000000        0.000000        0.000000 #> TSC2            0.000000        0.000000        0.000000        0.000000 #>          X58_Y-101..CD4T X56_Y-101..CD4T X55_Y-101..CD4T X60_Y-101..CD4T #> PDK4            0.000000               0        0.000000        0.000000 #> TNFRSF17        0.000000               0        0.000000        0.000000 #> ICAM3           4.453213               0        2.343499        1.400515 #> FAP             0.000000               0        0.000000        0.000000 #> GZMB            0.000000               0        0.000000        2.727895 #> TSC2            0.000000               0        0.000000        0.000000 #>          X57_Y-101..CD4T X57_Y-102..CD4T X59_Y-102..CD4T X58_Y-102..CD4T #> PDK4            0.000000        0.000000        0.000000        0.000000 #> TNFRSF17        0.000000        0.000000        0.000000        0.000000 #> ICAM3           5.149528        3.089717        2.828111        4.924887 #> FAP             0.000000        0.000000        0.000000        0.000000 #> GZMB            0.000000        0.000000        0.000000        0.000000 #> TSC2            0.000000        0.000000        0.000000        0.000000 #>          X57_Y-103..CD4T X60_Y-103..CD4T X58_Y-103..CD4T X56_Y-99..CD4T #> PDK4                   0        0.000000        0.000000      0.0000000 #> TNFRSF17               0        0.000000        0.000000      0.0000000 #> ICAM3                  0        1.736164        1.876805      3.1192857 #> FAP                    0        0.000000        0.000000      0.0000000 #> GZMB                   0        0.000000        1.286991      0.0000000 #> TSC2                   0        0.000000        0.000000      0.5158426 #>          X54_Y-100..CD4T X56_Y-100..CD4T X42_Y-98..CD4T X40_Y-99..CD4T #> PDK4            0.000000        0.000000              0              0 #> TNFRSF17        0.000000        0.000000              0              0 #> ICAM3           2.923452        5.050104              0              0 #> FAP             0.000000        0.000000              0              0 #> GZMB            0.000000        0.000000              0              0 #> TSC2            0.000000        0.000000              0              0 #>          X42_Y-99..CD4T X38_Y-100..CD4T X39_Y-100..CD4T X42_Y-100..CD4T #> PDK4           0.000000        0.000000         0.00000        0.000000 #> TNFRSF17       0.000000        0.000000         0.00000        0.000000 #> ICAM3          2.243233        5.631974         5.13598        2.493623 #> FAP            0.000000        0.000000         0.00000        0.000000 #> GZMB           0.000000        0.000000         0.00000        0.000000 #> TSC2           0.000000        0.000000         0.00000        0.000000 #>          X41_Y-101..CD4T X42_Y-101..CD4T X41_Y-102..CD4T X41_Y-103..CD4T #> PDK4            0.000000        0.000000        0.000000        0.000000 #> TNFRSF17        0.000000        0.000000        0.000000        0.000000 #> ICAM3           1.810625        1.039213        2.313935        1.531839 #> FAP             0.000000        0.000000        0.000000        0.000000 #> GZMB            0.000000        0.000000        0.000000        0.000000 #> TSC2            0.000000        0.000000        0.000000        0.000000 #>          X42_Y-103..CD4T X63_Y-86..CD4T X64_Y-86..CD4T X62_Y-86..CD4T #> PDK4            0.000000      0.0000000      0.0000000       0.000000 #> TNFRSF17        0.000000      0.0000000      0.0000000       0.000000 #> ICAM3           1.714088      2.7502745      2.7260971       2.943564 #> FAP             0.000000      0.0000000      0.0000000       0.000000 #> GZMB            0.000000      0.3184102      0.3184102       0.000000 #> TSC2            1.064682      0.2878984      0.0000000       1.199941 #>          X61_Y-86..CD4T X65_Y-86..CD4T X63_Y-87..CD4T X65_Y-87..CD4T #> PDK4           0.000000       0.000000       0.000000              0 #> TNFRSF17       0.000000       0.000000       0.000000              0 #> ICAM3          2.568591       3.154723       2.771202              0 #> FAP            0.000000       0.000000       0.000000              0 #> GZMB           0.000000       0.000000       0.000000              0 #> TSC2           0.453010       0.000000       0.000000              0 #>          X61_Y-87..CD4T X62_Y-87..CD4T X66_Y-87..CD4T X64_Y-87..CD4T #> PDK4           0.000000      0.0000000      0.0000000       0.000000 #> TNFRSF17       0.000000      0.0000000      0.0000000       0.000000 #> ICAM3          3.003513      3.0193249      2.9767598       3.835508 #> FAP            0.000000      0.0000000      0.0000000       0.000000 #> GZMB           0.000000      0.0000000      0.9827296       1.087039 #> TSC2           0.000000      0.4799766      0.0000000       0.000000 #>          X62_Y-88..CD4T X63_Y-88..CD4T X66_Y-88..CD4T X63_Y-89..CD4T #> PDK4           0.000000       0.000000       0.000000      0.0000000 #> TNFRSF17       0.000000       0.000000       0.000000      0.0000000 #> ICAM3          3.426962       4.008434       2.682441      2.5243719 #> FAP            0.000000       0.000000       0.000000      0.0000000 #> GZMB           0.000000       0.000000       0.000000      0.0000000 #> TSC2           0.000000       0.000000       0.000000      0.2365282 #>          X64_Y-89..CD4T X62_Y-89..CD4T X64_Y-90..CD4T X62_Y-90..CD4T #> PDK4           0.000000       0.000000      0.0000000      0.0000000 #> TNFRSF17       0.000000       0.000000      0.0000000      0.0000000 #> ICAM3          2.155859       1.539281      2.1741160      3.4608055 #> FAP            0.000000       0.000000      0.0000000      0.0000000 #> GZMB           0.000000       0.000000      0.9526613      0.2491932 #> TSC2           0.000000       0.000000      0.0000000      0.2459210 #>          X61_Y-90..CD4T X63_Y-90..CD4T X66_Y-90..CD4T X64_Y-88..CD4T #> PDK4           0.000000      0.0000000       0.000000       0.000000 #> TNFRSF17       0.000000      0.0000000       0.000000       0.000000 #> ICAM3          1.995478      3.7661280       4.650401       2.297758 #> FAP            0.000000      0.0000000       0.000000       0.000000 #> GZMB           0.000000      0.2130847       0.000000       0.000000 #> TSC2           0.000000      0.2213289       3.966766       0.000000 #>          X41_Y-92..CD4T X39_Y-92..CD4T X41_Y-93..CD4T X36_Y-93..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          1.765212       4.085632       1.067153       3.202189 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X38_Y-94..CD4T X39_Y-94..CD4T X37_Y-95..CD4T X41_Y-95..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          3.390351       5.089387       4.234501       2.704084 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X41_Y-96..CD4T X42_Y-96..CD4T X41_Y-97..CD4T X40_Y-97..CD4T #> PDK4           0.000000       0.000000       0.000000              0 #> TNFRSF17       0.000000       0.000000       0.000000              0 #> ICAM3          4.086292       3.262131       4.679647              0 #> FAP            0.000000       0.000000       0.000000              0 #> GZMB           0.000000       0.000000       0.000000              0 #> TSC2           0.000000       0.000000       0.000000              0 #>          X41_Y-104..CD4T X40_Y-104..CD4T X40_Y-105..CD4T X41_Y-105..CD4T #> PDK4            0.000000        0.000000       0.0000000        0.000000 #> TNFRSF17        0.000000        0.000000       0.0000000        0.000000 #> ICAM3           4.846617        3.620681       2.3025049        3.267796 #> FAP             0.000000        0.000000       0.0000000        0.000000 #> GZMB            1.021408        1.021408       0.6809387        1.021408 #> TSC2            0.000000        0.000000       0.0000000        0.000000 #>          X42_Y-105..CD4T X40_Y-106..CD4T X41_Y-106..CD4T X42_Y-106..CD4T #> PDK4            0.000000        0.000000        0.000000               0 #> TNFRSF17        0.000000        0.000000        0.000000               0 #> ICAM3           3.922071        1.143436        1.844187               0 #> FAP             0.000000        0.000000        0.000000               0 #> GZMB            0.000000        0.000000        0.000000               0 #> TSC2            0.000000        0.000000        0.000000               0 #>          X40_Y-107..CD4T X41_Y-107..CD4T X53_Y-85..CD4T X52_Y-86..CD4T #> PDK4           0.0000000       0.0000000       0.000000       0.000000 #> TNFRSF17       0.0000000       0.0000000       0.000000       0.000000 #> ICAM3          1.8954818       1.9553863       2.386111       2.420395 #> FAP            0.0000000       0.0000000       0.000000       0.000000 #> GZMB           0.3926936       0.4363262       0.000000       0.000000 #> TSC2           0.0000000       0.0000000       0.000000       0.000000 #>          X51_Y-86..CD4T X53_Y-86..CD4T X54_Y-86..CD4T X54_Y-87..CD4T #> PDK4           0.000000       0.000000      0.0000000      0.0000000 #> TNFRSF17       0.000000       0.000000      0.0000000      0.0000000 #> ICAM3          1.008866       3.330255      2.0417234      2.4330027 #> FAP            0.000000       0.000000      0.0000000      0.0000000 #> GZMB           0.000000       0.000000      0.6607245      0.3303623 #> TSC2           0.000000       0.000000      0.0000000      0.0000000 #>          X52_Y-87..CD4T X51_Y-87..CD4T X53_Y-87..CD4T X50_Y-87..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.279614       2.335344       3.180146       3.142733 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X49_Y-88..CD4T X52_Y-88..CD4T X51_Y-88..CD4T X54_Y-88..CD4T #> PDK4           0.000000       0.000000      0.0000000       0.000000 #> TNFRSF17       0.000000       0.000000      0.0000000       0.000000 #> ICAM3          2.037083       2.238497      2.0879430       2.427409 #> FAP            0.000000       0.000000      0.0000000       0.000000 #> GZMB           0.000000       0.000000      0.0000000       0.000000 #> TSC2           0.000000       0.000000      0.2653912       0.000000 #>          X53_Y-88..CD4T X50_Y-88..CD4T X48_Y-88..CD4T X53_Y-89..CD4T #> PDK4          0.0000000      0.0000000       0.000000      0.0000000 #> TNFRSF17      0.0000000      0.0000000       0.000000      0.0000000 #> ICAM3         2.1992076      2.4403847       2.498805      2.2747936 #> FAP           0.0000000      0.0000000       0.000000      0.0000000 #> GZMB          0.2903064      0.3386448       0.000000      0.4103065 #> TSC2          0.0000000      0.3878794       0.000000      0.4103065 #>          X52_Y-89..CD4T X54_Y-89..CD4T X50_Y-89..CD4T X49_Y-89..CD4T #> PDK4           0.000000       0.000000      0.0000000       0.000000 #> TNFRSF17       0.000000       0.000000      0.0000000       0.000000 #> ICAM3          3.266128       2.010267      2.6573552       3.631671 #> FAP            0.000000       0.000000      0.0000000       0.000000 #> GZMB           0.000000       0.000000      0.6289118       0.000000 #> TSC2           0.000000       0.000000      0.0000000       0.000000 #>          X51_Y-89..CD4T X50_Y-90..CD4T X54_Y-90..CD4T X49_Y-90..CD4T #> PDK4           0.000000      0.0000000      0.0000000       0.000000 #> TNFRSF17       0.000000      0.0000000      0.0000000       0.000000 #> ICAM3          4.683135      1.7611875      1.7400629       2.147897 #> FAP            0.000000      0.0000000      0.0000000       0.000000 #> GZMB           0.000000      0.0000000      0.5033148       0.000000 #> TSC2           0.000000      0.6125405      0.0000000       0.000000 #>          X53_Y-90..CD4T X51_Y-90..CD4T X52_Y-90..CD4T X52_Y-91..CD4T #> PDK4           0.000000       0.000000      0.0000000       0.000000 #> TNFRSF17       0.000000       0.000000      0.0000000       0.000000 #> ICAM3          4.625072       3.289106      2.4508600       1.569955 #> FAP            0.000000       0.000000      0.0000000       0.000000 #> GZMB           0.000000       0.000000      0.4689218       0.000000 #> TSC2           0.000000       0.000000      0.4689218       0.000000 #>          X53_Y-91..CD4T X55_Y-85..CD4T X57_Y-85..CD4T X60_Y-86..CD4T #> PDK4                  0       0.000000              0      0.0000000 #> TNFRSF17              0       0.000000              0      0.0000000 #> ICAM3                 0       4.013637              0      2.6636185 #> FAP                   0       0.000000              0      0.0000000 #> GZMB                  0       0.000000              0      0.5095399 #> TSC2                  0       0.000000              0      0.0000000 #>          X59_Y-86..CD4T X58_Y-86..CD4T X56_Y-86..CD4T X59_Y-87..CD4T #> PDK4           0.000000      0.0000000       0.000000       0.000000 #> TNFRSF17       0.000000      0.0000000       0.000000       0.000000 #> ICAM3          1.442402      0.7181806       2.583753       2.824237 #> FAP            0.000000      0.0000000       0.000000       0.000000 #> GZMB           0.000000      0.0000000       0.000000       0.804874 #> TSC2           0.000000      0.0000000       0.000000       0.000000 #>          X56_Y-87..CD4T X57_Y-87..CD4T X55_Y-88..CD4T X57_Y-88..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          1.556809       2.699422       1.373178       1.994705 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X58_Y-88..CD4T X57_Y-89..CD4T X55_Y-89..CD4T X56_Y-89..CD4T #> PDK4             0.0000      0.0000000        0.00000       0.000000 #> TNFRSF17         0.0000      0.0000000        0.00000       0.000000 #> ICAM3            1.7147      2.6527565        1.86821       1.622743 #> FAP              0.0000      0.0000000        0.00000       0.000000 #> GZMB             0.0000      0.3114399        0.00000       0.000000 #> TSC2             0.0000      0.0000000        0.00000       0.000000 #>          X58_Y-89..CD4T X57_Y-90..CD4T X55_Y-90..CD4T X56_Y-90..CD4T #> PDK4          0.0000000      0.0000000      0.0000000      0.0000000 #> TNFRSF17      0.0000000      0.0000000      0.0000000      0.0000000 #> ICAM3         2.7925208      3.7455124      2.7368811      2.2205403 #> FAP           0.0000000      0.0000000      0.0000000      0.0000000 #> GZMB          0.4671599      0.0000000      0.5033148      0.3629768 #> TSC2          0.0000000      0.2471757      0.0000000      0.0000000 #>          X58_Y-90..CD4T X55_Y-86..CD4T X58_Y-87..CD4T X59_Y-89..CD4T #> PDK4           0.000000       0.000000       0.000000              0 #> TNFRSF17       0.000000       0.000000       0.000000              0 #> ICAM3          2.334596       4.485477       2.012185              0 #> FAP            0.000000       0.000000       0.000000              0 #> GZMB           0.000000       0.000000       2.012185              0 #> TSC2           0.000000       0.000000       0.000000              0 #>          X59_Y-90..CD4T X55_Y-64..CD4T X56_Y-65..CD4T X55_Y-66..CD4T #> PDK4           0.000000       0.000000       0.000000      0.0000000 #> TNFRSF17       0.000000       0.000000       0.000000      0.0000000 #> ICAM3          2.386402       3.345307       2.010557      2.8650200 #> FAP            0.000000       0.000000       0.000000      0.0000000 #> GZMB           0.000000       0.000000       0.000000      0.0000000 #> TSC2           0.000000       0.000000       0.000000      0.6193419 #>          X56_Y-64..CD4T X72_Y-64..CD4T X72_Y-65..CD4T X71_Y-65..CD4T #> PDK4            0.00000       0.000000       0.000000       0.000000 #> TNFRSF17        0.00000       0.000000       0.000000       0.000000 #> ICAM3           2.28222       3.380598       2.387769       2.947649 #> FAP             0.00000       0.000000       0.000000       0.000000 #> GZMB            0.00000       0.000000       0.000000       0.000000 #> TSC2            0.00000       0.000000       0.000000       0.000000 #>          X70_Y-64..CD4T X71_Y-66..CD4T X67_Y-66..CD4T X70_Y-66..CD4T #> PDK4                  0       0.000000       0.000000       0.000000 #> TNFRSF17              0       0.000000       0.000000       0.000000 #> ICAM3                 0       2.009494       4.730565       4.418446 #> FAP                   0       0.000000       0.000000       0.000000 #> GZMB                  0       0.000000       5.419291       0.000000 #> TSC2                  0       0.000000       0.000000       0.000000 #>          X49_Y-99..CD4T X52_Y-99..CD4T X53_Y-100..CD4T X52_Y-100..CD4T #> PDK4            0.00000       0.000000        0.000000         0.00000 #> TNFRSF17        0.00000       0.000000        0.000000         0.00000 #> ICAM3           2.72096       2.324919        2.256656         1.46089 #> FAP             0.00000       0.000000        0.000000         0.00000 #> GZMB            0.00000       0.000000        0.000000         0.00000 #> TSC2            0.00000       0.000000        0.000000         0.00000 #>          X50_Y-100..CD4T X49_Y-100..CD4T X48_Y-100..CD4T X49_Y-101..CD4T #> PDK4             0.00000        0.000000        0.000000        0.000000 #> TNFRSF17         0.00000        0.000000        0.000000        0.000000 #> ICAM3            2.09983        2.718009        4.941713        1.570502 #> FAP              0.00000        0.000000        0.000000        0.000000 #> GZMB             0.00000        0.000000        0.000000        0.000000 #> TSC2             0.00000        0.000000        0.000000        0.000000 #>          X48_Y-101..CD4T X51_Y-101..CD4T X53_Y-101..CD4T X53_Y-102..CD4T #> PDK4            0.000000               0               0               0 #> TNFRSF17        0.000000               0               0               0 #> ICAM3           2.758504               0               0               0 #> FAP             0.000000               0               0               0 #> GZMB            0.000000               0               0               0 #> TSC2            0.000000               0               0               0 #>          X50_Y-102..CD4T X49_Y-102..CD4T X52_Y-102..CD4T X55_Y-103..CD4T #> PDK4            0.000000        0.000000        0.000000        0.000000 #> TNFRSF17        0.000000        0.000000        0.000000        0.000000 #> ICAM3           2.306958        1.325826        1.893269        4.392397 #> FAP             0.000000        0.000000        0.000000        0.000000 #> GZMB            0.000000        0.000000        0.000000        0.000000 #> TSC2            0.000000        0.000000        1.893269        0.000000 #>          X51_Y-104..CD4T X54_Y-104..CD4T X49_Y-98..CD4T X50_Y-99..CD4T #> PDK4               0.000        0.000000        0.00000       0.000000 #> TNFRSF17           0.000        0.000000        0.00000       0.000000 #> ICAM3              4.714        3.443066        2.72096       2.389325 #> FAP                0.000        0.000000        0.00000       0.000000 #> GZMB               0.000        0.000000        0.00000       0.000000 #> TSC2               0.000        0.000000        0.00000       0.000000 #>          X51_Y-99..CD4T X51_Y-100..CD4T X52_Y-101..CD4T X54_Y-101..CD4T #> PDK4           0.000000         0.00000               0               0 #> TNFRSF17       0.000000         0.00000               0               0 #> ICAM3          1.612094         1.20907               0               0 #> FAP            0.000000         0.00000               0               0 #> GZMB           0.000000         0.00000               0               0 #> TSC2           0.000000         0.00000               0               0 #>          X44_Y-98..CD4T X47_Y-98..CD4T X48_Y-99..CD4T X43_Y-99..CD4T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          3.635371       1.506933       3.168274       3.273992 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       1.377586       0.000000 #>          X43_Y-100..CD4T X44_Y-100..CD4T X44_Y-101..CD4T X47_Y-101..CD4T #> PDK4            0.000000        0.000000        0.000000       0.0000000 #> TNFRSF17        0.000000        0.000000        0.000000       0.0000000 #> ICAM3           2.192507        3.297118        4.200292       0.9994398 #> FAP             0.000000        0.000000        0.000000       0.0000000 #> GZMB            0.000000        0.000000        0.000000       0.0000000 #> TSC2            0.000000        0.000000        0.000000       0.0000000 #>          X46_Y-101..CD4T X42_Y-102..CD4T X43_Y-102..CD4T X47_Y-100..CD4T #> PDK4            0.000000        0.000000        0.000000        0.000000 #> TNFRSF17        0.000000        0.000000        0.000000        0.000000 #> ICAM3           3.997759        2.331420        3.559705        2.888209 #> FAP             0.000000        0.000000        0.000000        0.000000 #> GZMB            0.000000        0.000000        0.000000        0.000000 #> TSC2            0.000000        0.665426        0.000000        0.000000 #>          X48_Y-102..CD4T X44_Y-102..CD4T X43_Y-103..CD4T X47_Y-103..CD4T #> PDK4            0.000000               0               0        0.000000 #> TNFRSF17        0.000000               0               0        0.000000 #> ICAM3           2.651652               0               0        2.658331 #> FAP             0.000000               0               0        0.000000 #> GZMB            0.000000               0               0        0.000000 #> TSC2            0.000000               0               0        0.000000 #>          X28_Y-94..CD8T X26_Y-96..CD8T X26_Y-97..CD8T X27_Y-96..CD8T #> PDK4                  0       0.000000       0.000000              0 #> TNFRSF17              0       0.000000       0.000000              0 #> ICAM3                 0       2.636273       2.877562              0 #> FAP                   0       0.000000       0.000000              0 #> GZMB                  0       0.000000       0.000000              0 #> TSC2                  0       0.000000       0.000000              0 #>          X64_Y-91..CD8T X61_Y-91..CD8T X62_Y-91..CD8T X61_Y-92..CD8T #> PDK4           0.000000       0.000000       0.000000      0.0000000 #> TNFRSF17       0.000000       0.000000       0.000000      0.0000000 #> ICAM3          0.000000       4.066063       5.639749      2.6656890 #> FAP            0.000000       0.000000       0.000000      0.0000000 #> GZMB           4.214594       1.246369       4.749024      0.5807491 #> TSC2           0.000000       0.000000       0.000000      0.0000000 #>          X60_Y-92..CD8T X64_Y-92..CD8T X62_Y-93..CD8T X64_Y-93..CD8T #> PDK4           0.000000        0.00000       0.000000       0.000000 #> TNFRSF17       0.000000        0.00000       0.000000       0.000000 #> ICAM3          3.086627        5.50999       2.671751       3.673326 #> FAP            0.000000        0.00000       0.000000       0.000000 #> GZMB           0.000000        0.00000       0.000000       0.000000 #> TSC2           0.000000        0.00000       0.000000       1.707326 #>          X64_Y-94..CD8T X63_Y-95..CD8T X62_Y-96..CD8T X62_Y-92..CD8T #> PDK4           0.000000        0.00000              0      0.0000000 #> TNFRSF17       0.000000        0.00000              0      0.0000000 #> ICAM3          2.052819        0.00000              0      2.6481131 #> FAP            0.000000        0.00000              0      0.0000000 #> GZMB           0.000000        5.32853              0      0.7759244 #> TSC2           1.707326        0.00000              0      0.0000000 #>          X58_Y-91..CD8T X57_Y-91..CD8T X59_Y-91..CD8T X55_Y-92..CD8T #> PDK4          0.0000000      0.0000000      0.0000000       0.000000 #> TNFRSF17      0.0000000      0.0000000      0.0000000       0.000000 #> ICAM3         3.5450852      3.2825575      1.5833438       0.000000 #> FAP           0.0000000      0.0000000      0.0000000       0.000000 #> GZMB          0.5533222      0.7222006      2.3105681       2.393944 #> TSC2          0.5268242      0.0000000      0.7902942       0.000000 #>          X56_Y-92..CD8T X58_Y-92..CD8T X59_Y-92..CD8T X58_Y-93..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          0.000000       3.231059       3.851422       5.416065 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           4.989231       0.000000       1.900406       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X59_Y-93..CD8T X54_Y-93..CD8T X57_Y-93..CD8T X55_Y-94..CD8T #> PDK4           0.000000      0.0000000       0.000000       0.000000 #> TNFRSF17       0.000000      0.0000000       0.000000       0.000000 #> ICAM3          4.529207      3.0791222       4.836282       1.711365 #> FAP            0.000000      0.0000000       0.000000       0.000000 #> GZMB           1.284671      0.0000000       0.000000       1.598592 #> TSC2           0.000000      0.7389961       0.000000       0.000000 #>          X59_Y-94..CD8T X54_Y-94..CD8T X60_Y-94..CD8T X55_Y-95..CD8T #> PDK4           0.000000      0.0000000       0.000000       0.000000 #> TNFRSF17       0.000000      0.0000000       0.000000       0.000000 #> ICAM3          1.828266      2.2379415       0.000000       2.256974 #> FAP            0.000000      0.0000000       0.000000       0.000000 #> GZMB           0.000000      0.6725372       0.000000       1.408283 #> TSC2           1.595963      0.0000000       2.393944       0.000000 #>          X57_Y-95..CD8T X56_Y-95..CD8T X57_Y-96..CD8T X56_Y-96..CD8T #> PDK4           0.000000      0.0000000      0.0000000      0.0000000 #> TNFRSF17       0.000000      0.0000000      0.0000000      0.0000000 #> ICAM3          2.947211      2.4540000      2.5937309      3.3763498 #> FAP            0.000000      0.0000000      0.0000000      0.0000000 #> GZMB           0.000000      0.4665919      0.5196002      0.3597232 #> TSC2           0.000000      0.0000000      0.0000000      0.3759368 #>          X59_Y-96..CD8T X58_Y-96..CD8T X58_Y-97..CD8T X55_Y-97..CD8T #> PDK4                  0       0.000000       0.000000      0.0000000 #> TNFRSF17              0       0.000000       0.000000      0.0000000 #> ICAM3                 0       2.456824       2.308031      2.4964971 #> FAP                   0       0.000000       0.000000      0.0000000 #> GZMB                  0       0.000000       2.458916      0.9943451 #> TSC2                  0       2.213289       0.000000      0.0000000 #>          X56_Y-97..CD8T X59_Y-97..CD8T X57_Y-97..CD8T X56_Y-94..CD8T #> PDK4          0.0000000       0.000000      0.0000000       0.000000 #> TNFRSF17      0.0000000       0.000000      0.0000000       0.000000 #> ICAM3         3.4304663       3.105362      0.7691868       1.725327 #> FAP           0.0000000       0.000000      0.0000000       0.000000 #> GZMB          0.0000000       3.253465      0.9195312       1.430525 #> TSC2          0.3054486       0.000000      0.0000000       0.000000 #>          X55_Y-98..CD8T X75_Y-98..CD8T X77_Y-99..CD8T X77_Y-85..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.537762       0.000000       5.303305       5.264283 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           1.612432       0.000000       0.000000       0.000000 #> TSC2           0.303916       4.741765       0.000000       0.000000 #>          X75_Y-90..CD8T X78_Y-91..CD8T X30_Y-73..CD8T X39_Y-70..CD8T #> PDK4           0.000000        0.00000       0.000000       0.000000 #> TNFRSF17       0.000000        0.00000       0.000000       0.000000 #> ICAM3          5.550671        5.46899       0.000000       4.817854 #> FAP            0.000000        0.00000       0.000000       0.000000 #> GZMB           0.000000        5.46899       5.476862       0.000000 #> TSC2           0.000000        0.00000       0.000000       0.000000 #>          X40_Y-72..CD8T X39_Y-72..CD8T X41_Y-68..CD8T X40_Y-73..CD8T #> PDK4          0.0000000      0.0000000       0.000000       0.000000 #> TNFRSF17      0.0000000      0.0000000       0.000000       0.000000 #> ICAM3         0.9942467      0.9942467       5.658486       1.988493 #> FAP           0.0000000      0.0000000       0.000000       0.000000 #> GZMB          0.0000000      0.0000000       0.000000       0.000000 #> TSC2          0.0000000      0.0000000       0.000000       0.000000 #>          X40_Y-75..CD8T X37_Y-78..CD8T X39_Y-75..CD8T X73_Y-73..CD8T #> PDK4             0.0000       0.000000         0.0000      0.0000000 #> TNFRSF17         0.0000       0.000000         0.0000      0.0000000 #> ICAM3            2.0457       5.364882         2.0457      3.2555468 #> FAP              0.0000       0.000000         0.0000      0.0000000 #> GZMB             0.0000       0.000000         0.0000      0.0000000 #> TSC2             0.0000       0.000000         0.0000      0.8145297 #>          X74_Y-73..CD8T X77_Y-74..CD8T X75_Y-75..CD8T X73_Y-75..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          3.190872       2.775336       5.408168       2.540702 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       2.197225 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X76_Y-75..CD8T X77_Y-75..CD8T X76_Y-76..CD8T X78_Y-77..CD8T #> PDK4           0.000000       0.000000       0.000000              0 #> TNFRSF17       0.000000       0.000000       0.000000              0 #> ICAM3          1.522275       1.522275       3.344037              0 #> FAP            0.000000       0.000000       0.000000              0 #> GZMB           0.000000       0.000000       3.138587              0 #> TSC2           0.000000       0.000000       0.000000              0 #>          X77_Y-77..CD8T X76_Y-77..CD8T X77_Y-78..CD8T X74_Y-79..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.032958       0.000000       1.541691       0.000000 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.948353       2.569343       0.000000       5.453431 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X75_Y-77..CD8T X61_Y-67..CD8T X61_Y-68..CD8T X63_Y-70..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          6.099073       2.393944       3.829301       1.680811 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       2.144835       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X65_Y-70..CD8T X62_Y-71..CD8T X65_Y-71..CD8T X64_Y-71..CD8T #> PDK4           0.000000              0       0.000000       0.000000 #> TNFRSF17       0.000000              0       0.000000       0.000000 #> ICAM3          1.925955              0       1.925955       3.156336 #> FAP            0.000000              0       0.000000       0.000000 #> GZMB           0.000000              0       0.000000       0.000000 #> TSC2           0.000000              0       0.000000       0.000000 #>          X65_Y-72..CD8T X64_Y-72..CD8T X63_Y-72..CD8T X67_Y-73..CD8T #> PDK4          0.0000000      0.0000000              0       0.000000 #> TNFRSF17      0.0000000      0.0000000              0       0.000000 #> ICAM3         1.6282114      0.6465605              0       2.357021 #> FAP           0.0000000      0.0000000              0       0.000000 #> GZMB          0.7844143      0.0000000              0       1.093461 #> TSC2          0.0000000      0.0000000              0       0.630304 #>          X63_Y-69..CD8T X62_Y-69..CD8T X62_Y-72..CD8T X64_Y-73..CD8T #> PDK4                  0       0.000000              0              0 #> TNFRSF17              0       0.000000              0              0 #> ICAM3                 0       0.000000              0              0 #> FAP                   0       0.000000              0              0 #> GZMB                  0       4.900324              0              0 #> TSC2                  0       0.000000              0              0 #>          X66_Y-73..CD8T X65_Y-73..CD8T X64_Y-74..CD8T X65_Y-74..CD8T #> PDK4           0.000000              0       0.000000       0.000000 #> TNFRSF17       0.000000              0       0.000000       0.000000 #> ICAM3          1.444069              0       1.328326       0.000000 #> FAP            0.000000              0       0.000000       0.000000 #> GZMB           0.000000              0       2.476846       4.200369 #> TSC2           0.000000              0       0.000000       0.000000 #>          X66_Y-74..CD8T X65_Y-75..CD8T X64_Y-75..CD8T X67_Y-76..CD8T #> PDK4           0.000000       0.000000              0      0.0000000 #> TNFRSF17       0.000000       0.000000              0      0.0000000 #> ICAM3          2.217389       2.463577              0      2.4287779 #> FAP            0.000000       0.000000              0      0.0000000 #> GZMB           0.000000       2.687764              0      0.8696374 #> TSC2           0.000000       0.000000              0      0.0000000 #>          X64_Y-76..CD8T X63_Y-76..CD8T X66_Y-77..CD8T X60_Y-77..CD8T #> PDK4           0.000000              0      0.0000000       0.000000 #> TNFRSF17       0.000000              0      0.0000000       0.000000 #> ICAM3          4.378773              0      0.9461129       4.793809 #> FAP            0.000000              0      0.0000000       0.000000 #> GZMB           0.000000              0      0.0000000       0.000000 #> TSC2           0.000000              0      0.0000000       0.000000 #>          X63_Y-73..CD8T X62_Y-73..CD8T X62_Y-74..CD8T X66_Y-76..CD8T #> PDK4            0.00000       0.000000       0.000000              0 #> TNFRSF17        0.00000       0.000000       0.000000              0 #> ICAM3           0.00000       0.000000       0.000000              0 #> FAP             0.00000       0.000000       0.000000              0 #> GZMB            1.81781       3.298826       3.926936              0 #> TSC2            0.00000       0.000000       0.000000              0 #>          X67_Y-77..CD8T X63_Y-78..CD8T X73_Y-72..CD8T X72_Y-73..CD8T #> PDK4          0.0000000              0       0.000000      0.0000000 #> TNFRSF17      0.0000000              0       0.000000      0.0000000 #> ICAM3         2.1563316              0       1.640048      2.8518588 #> FAP           0.0000000              0       0.000000      0.0000000 #> GZMB          0.6200932              0       0.452080      1.4204279 #> TSC2          0.0000000              0       0.000000      0.4442889 #>          X68_Y-73..CD8T X71_Y-74..CD8T X72_Y-74..CD8T X67_Y-74..CD8T #> PDK4          0.0000000      0.0000000      0.0000000      0.0000000 #> TNFRSF17      0.0000000      0.0000000      0.0000000      0.0000000 #> ICAM3         0.7668074      2.0429491      2.2188250      1.4951361 #> FAP           0.0000000      0.0000000      0.0000000      0.0000000 #> GZMB          1.5653122      0.4983864      0.7073108      1.4155788 #> TSC2          1.0084864      0.4983864      0.0000000      0.5602702 #>          X68_Y-74..CD8T X69_Y-74..CD8T X67_Y-75..CD8T X69_Y-75..CD8T #> PDK4          0.0000000       0.000000       0.000000       0.000000 #> TNFRSF17      0.0000000       0.000000       0.000000       0.000000 #> ICAM3         2.7548555       2.964350       2.404904       3.120317 #> FAP           0.0000000       0.000000       0.000000       0.000000 #> GZMB          0.3905832       1.304315       1.042418       1.448688 #> TSC2          0.0000000       0.000000       0.000000       0.000000 #>          X71_Y-75..CD8T X68_Y-75..CD8T X72_Y-75..CD8T X70_Y-75..CD8T #> PDK4          0.0000000       0.000000      0.0000000      0.0000000 #> TNFRSF17      0.0000000       0.000000      0.0000000      0.0000000 #> ICAM3         1.9921136       3.797324      1.5087171      2.9721683 #> FAP           0.0000000       0.000000      0.0000000      0.0000000 #> GZMB          0.8263349       0.556925      0.7475796      1.4892872 #> TSC2          0.3737898       0.000000      0.7475796      0.4268613 #>          X70_Y-76..CD8T X69_Y-76..CD8T X68_Y-76..CD8T X71_Y-76..CD8T #> PDK4          0.0000000       0.000000      0.0000000       0.000000 #> TNFRSF17      0.0000000       0.000000      0.0000000       0.000000 #> ICAM3         2.7347365       3.068402      3.3006275       3.302682 #> FAP           0.0000000       0.000000      0.0000000       0.000000 #> GZMB          2.2685281       1.031136      0.9698781       1.943210 #> TSC2          0.3557178       0.000000      0.3275613       0.000000 #>          X68_Y-77..CD8T X70_Y-77..CD8T X69_Y-77..CD8T X71_Y-77..CD8T #> PDK4          0.0000000        0.00000      0.0000000              0 #> TNFRSF17      0.0000000        0.00000      0.0000000              0 #> ICAM3         3.4417921        1.23044      2.8369101              0 #> FAP           0.0000000        0.00000      0.0000000              0 #> GZMB          1.5301743        0.00000      1.2598488              0 #> TSC2          0.3821549        0.00000      0.5445375              0 #>          X69_Y-78..CD8T X70_Y-78..CD8T X72_Y-78..CD8T X71_Y-78..CD8T #> PDK4          0.0000000      0.0000000       0.000000       0.000000 #> TNFRSF17      0.0000000      0.0000000       0.000000       0.000000 #> ICAM3         3.3440310      2.3188107       2.322641       4.599839 #> FAP           0.0000000      0.0000000       0.000000       0.000000 #> GZMB          0.7913279      0.6303040       0.000000       3.691381 #> TSC2          0.8529123      0.5502978       0.000000       0.000000 #>          X72_Y-79..CD8T X68_Y-79..CD8T X72_Y-76..CD8T X68_Y-78..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.322641       1.420565       2.666807       2.632142 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       2.288148 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X71_Y-79..CD8T X57_Y-75..CD8T X54_Y-75..CD8T X55_Y-77..CD8T #> PDK4          0.0000000       0.000000       0.000000      0.0000000 #> TNFRSF17      0.0000000       0.000000       0.000000      0.0000000 #> ICAM3         3.2570913       2.297758       1.704576      2.6739967 #> FAP           0.0000000       0.000000       0.000000      0.0000000 #> GZMB          3.3993232       2.843687       3.066564      0.5602959 #> TSC2          0.7759244       0.000000       0.000000      0.0000000 #>          X54_Y-77..CD8T X55_Y-78..CD8T X54_Y-79..CD8T X55_Y-79..CD8T #> PDK4           0.000000      0.0000000      0.0000000       0.000000 #> TNFRSF17       0.000000      0.0000000      0.0000000       0.000000 #> ICAM3          2.646368      1.8516351      2.7515059       1.040855 #> FAP            0.000000      0.0000000      0.0000000       0.000000 #> GZMB           1.662488      0.7184749      1.1520843       0.000000 #> TSC2           0.000000      0.0000000      0.3437141       0.000000 #>          X56_Y-79..CD8T X55_Y-75..CD8T X54_Y-76..CD8T X54_Y-78..CD8T #> PDK4           0.000000       0.000000      0.0000000      0.0000000 #> TNFRSF17       0.000000       0.000000      0.0000000      0.0000000 #> ICAM3          1.387807       5.293404      2.4952312      2.9393540 #> FAP            0.000000       0.000000      0.0000000      0.0000000 #> GZMB           0.000000       4.605269      0.6419852      0.3922071 #> TSC2           0.000000       0.000000      0.0000000      0.0000000 #>          X73_Y-66..CD8T X68_Y-67..CD8T X73_Y-68..CD8T X68_Y-68..CD8T #> PDK4           0.000000      0.0000000       0.000000       0.000000 #> TNFRSF17       0.000000      0.0000000       0.000000       0.000000 #> ICAM3          2.671707      1.1464647       1.858254       1.356178 #> FAP            0.000000      0.0000000       0.000000       0.000000 #> GZMB           1.470474      0.0000000       1.252686       1.356178 #> TSC2           0.000000      0.9757137       0.000000       1.172299 #>          X69_Y-68..CD8T X72_Y-69..CD8T X68_Y-69..CD8T X73_Y-69..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          1.356178       4.860139       1.088931       2.860219 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           1.356178       5.202882       2.179822       2.552675 #> TSC2           1.172299       0.000000       0.000000       0.000000 #>          X69_Y-69..CD8T X71_Y-70..CD8T X68_Y-70..CD8T X69_Y-70..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          3.057255       4.768901       0.000000       1.736164 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       2.087982       5.014111       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X73_Y-70..CD8T X67_Y-70..CD8T X73_Y-71..CD8T X70_Y-71..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          4.178846       2.521216       2.064839       5.208492 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       4.998584       1.564425       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X72_Y-71..CD8T X67_Y-71..CD8T X72_Y-72..CD8T X71_Y-73..CD8T #> PDK4           0.000000              0       0.000000       0.000000 #> TNFRSF17       0.000000              0       0.000000       0.000000 #> ICAM3          1.996284              0       2.396339       2.298401 #> FAP            0.000000              0       0.000000       0.000000 #> GZMB           1.611351              0       2.404436       2.418805 #> TSC2           0.000000              0       0.000000       0.000000 #>          X69_Y-66..CD8T X67_Y-67..CD8T X72_Y-68..CD8T X71_Y-69..CD8T #> PDK4                  0       0.000000       0.000000       0.000000 #> TNFRSF17              0       0.000000       0.000000       0.000000 #> ICAM3                 0       1.528620       1.985406       4.814520 #> FAP                   0       0.000000       0.000000       0.000000 #> GZMB                  0       0.000000       2.803550       3.645432 #> TSC2                  0       1.300952       0.000000       0.000000 #>          X72_Y-70..CD8T X70_Y-70..CD8T X49_Y-72..CD8T X52_Y-73..CD8T #> PDK4           0.000000       0.000000       0.000000      0.0000000 #> TNFRSF17       0.000000       0.000000       0.000000      0.0000000 #> ICAM3          3.003428       2.604246       2.902173      4.6466942 #> FAP            0.000000       0.000000       0.000000      0.0000000 #> GZMB           1.131958       1.923706       2.593947      0.8376117 #> TSC2           0.000000       0.000000       0.000000      0.0000000 #>          X50_Y-73..CD8T X48_Y-74..CD8T X54_Y-74..CD8T X51_Y-74..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.982651       1.597077       2.359745       2.903613 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           3.119573       2.268913       2.193290       1.623449 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X52_Y-74..CD8T X50_Y-74..CD8T X53_Y-74..CD8T X52_Y-75..CD8T #> PDK4           0.000000      0.0000000       0.000000       0.000000 #> TNFRSF17       0.000000      0.0000000       0.000000       0.000000 #> ICAM3          2.931699      1.0976266       1.616756       2.419815 #> FAP            0.000000      0.0000000       0.000000       0.000000 #> GZMB           2.153573      0.9274194       2.746963       3.834021 #> TSC2           0.000000      0.0000000       0.000000       0.000000 #>          X53_Y-75..CD8T X53_Y-76..CD8T X53_Y-77..CD8T X52_Y-77..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          1.979849       1.993688       2.211148       2.234142 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           3.563991       2.091131       3.057047       2.595287 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X48_Y-77..CD8T X49_Y-77..CD8T X50_Y-77..CD8T X49_Y-78..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.032909       1.183571       1.578095       2.484391 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           1.021408       2.235436       2.980582       1.392216 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X53_Y-78..CD8T X51_Y-78..CD8T X52_Y-78..CD8T X48_Y-78..CD8T #> PDK4           0.000000      0.0000000      0.0000000       0.000000 #> TNFRSF17       0.000000      0.0000000      0.0000000       0.000000 #> ICAM3          3.970002      1.2983756      1.0229988       1.665422 #> FAP            0.000000      0.0000000      0.0000000       0.000000 #> GZMB           1.163684      3.5213572      3.1516168       0.510704 #> TSC2           0.000000      0.3617165      0.4521457       0.000000 #>          X50_Y-79..CD8T X52_Y-79..CD8T X53_Y-79..CD8T X49_Y-79..CD8T #> PDK4          0.0000000       0.000000       0.000000      0.0000000 #> TNFRSF17      0.0000000       0.000000       0.000000      0.0000000 #> ICAM3         3.2625132       1.606956       2.849689      4.4027769 #> FAP           0.0000000       0.000000       0.000000      0.0000000 #> GZMB          0.8702735       1.027986       1.427712      0.4612267 #> TSC2          0.3914913       0.000000       0.000000      0.5654874 #>          X49_Y-73..CD8T X51_Y-73..CD8T X49_Y-74..CD8T X44_Y-91..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          0.000000       3.098505       2.982651       3.358216 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           3.891221       1.610591       3.119573       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X48_Y-91..CD8T X48_Y-92..CD8T X47_Y-92..CD8T X46_Y-92..CD8T #> PDK4           0.000000      0.0000000      0.0000000      0.0000000 #> TNFRSF17       0.000000      0.0000000      0.0000000      0.0000000 #> ICAM3          4.261882      2.8526660      2.7514299      2.6400312 #> FAP            0.000000      0.0000000      0.0000000      0.0000000 #> GZMB           1.361057      0.8394405      0.6616755      0.6616755 #> TSC2           0.000000      0.0000000      0.0000000      0.0000000 #>          X44_Y-92..CD8T X43_Y-92..CD8T X47_Y-93..CD8T X46_Y-93..CD8T #> PDK4           0.000000        0.00000       0.000000       0.000000 #> TNFRSF17       0.000000        0.00000       0.000000       0.000000 #> ICAM3          2.858564        4.97594       3.483684       2.908412 #> FAP            0.000000        0.00000       0.000000       0.000000 #> GZMB           0.000000        0.00000       1.058681       0.000000 #> TSC2           0.000000        0.00000       0.000000       0.000000 #>          X45_Y-93..CD8T X45_Y-94..CD8T X46_Y-94..CD8T X46_Y-95..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.297758       1.226361       3.092300       2.554068 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       1.453175       1.316586       2.547080 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X44_Y-95..CD8T X47_Y-95..CD8T X48_Y-95..CD8T X45_Y-96..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          5.386288       2.177156       4.354312       1.063138 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X44_Y-96..CD8T X47_Y-96..CD8T X44_Y-97..CD8T X46_Y-97..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          5.226742       2.604246       5.760338       4.459799 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       2.949450       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X45_Y-91..CD8T X45_Y-92..CD8T X47_Y-94..CD8T X24_Y-76..CD8T #> PDK4           0.000000              0       0.000000       0.000000 #> TNFRSF17       0.000000              0       0.000000       0.000000 #> ICAM3          2.292929              0       0.000000       5.019766 #> FAP            0.000000              0       0.000000       0.000000 #> GZMB           2.393944              0       1.886162       0.000000 #> TSC2           2.051518              0       0.000000       0.000000 #>          X33_Y-71..CD8T X30_Y-72..CD8T X36_Y-80..CD8T X21_Y-66..CD8T #> PDK4           0.000000       0.000000       0.000000              0 #> TNFRSF17       0.000000       0.000000       0.000000              0 #> ICAM3          5.050104       4.221184       4.865342              0 #> FAP            0.000000       0.000000       0.000000              0 #> GZMB           0.000000       0.000000       2.189387              0 #> TSC2           0.000000       0.000000       0.000000              0 #>          X25_Y-70..CD8T X26_Y-72..CD8T X46_Y-65..CD8T X43_Y-65..CD8T #> PDK4           0.000000        0.00000       0.000000       0.000000 #> TNFRSF17       0.000000        0.00000       0.000000       0.000000 #> ICAM3          4.402383        4.71949       4.355722       4.340652 #> FAP            0.000000        0.00000       0.000000       0.000000 #> GZMB           4.402383        0.00000       0.000000       5.027264 #> TSC2           0.000000        0.00000       0.000000       0.000000 #>          X47_Y-66..CD8T X45_Y-66..CD8T X46_Y-67..CD8T X46_Y-66..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          5.042432       4.812979       3.013379       2.382278 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X54_Y-64..CD8T X48_Y-64..CD8T X53_Y-64..CD8T X54_Y-65..CD8T #> PDK4           0.000000              0      0.0000000       0.000000 #> TNFRSF17       0.000000              0      0.0000000       0.000000 #> ICAM3          2.954698              0      2.2544884       2.416070 #> FAP            0.000000              0      0.0000000       0.000000 #> GZMB           1.829717              0      0.6138275       1.400037 #> TSC2           0.000000              0      0.0000000       0.000000 #>          X52_Y-65..CD8T X53_Y-65..CD8T X51_Y-66..CD8T X52_Y-66..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.081694       2.708072       4.116978       3.109905 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.596098       0.878334       0.000000       1.489232 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X54_Y-66..CD8T X52_Y-64..CD8T X51_Y-65..CD8T X48_Y-65..CD8T #> PDK4           0.000000       0.000000       0.000000              0 #> TNFRSF17       0.000000       0.000000       0.000000              0 #> ICAM3          4.324836       3.122541       3.971361              0 #> FAP            0.000000       0.000000       0.000000              0 #> GZMB           0.000000       0.894147       0.000000              0 #> TSC2           0.000000       0.000000       0.000000              0 #>          X37_Y-79..CD8T X37_Y-82..CD8T X42_Y-82..CD8T X42_Y-83..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          4.590686       4.730565       5.488788       5.077353 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           2.450162       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X37_Y-83..CD8T X37_Y-84..CD8T X44_Y-73..CD8T X48_Y-73..CD8T #> PDK4           0.000000              0       0.000000      0.0000000 #> TNFRSF17       0.000000              0       0.000000      0.0000000 #> ICAM3          2.446865              0       4.443047      2.1631170 #> FAP            0.000000              0       0.000000      0.0000000 #> GZMB           0.000000              0       0.000000      3.6720049 #> TSC2           0.000000              0       0.000000      0.5542305 #>          X47_Y-73..CD8T X43_Y-74..CD8T X46_Y-74..CD8T X47_Y-74..CD8T #> PDK4          0.0000000              0       0.000000       0.000000 #> TNFRSF17      0.0000000              0       0.000000       0.000000 #> ICAM3         3.1442880              0       5.266346       2.161914 #> FAP           0.0000000              0       0.000000       0.000000 #> GZMB          1.6484800              0       0.000000       1.342973 #> TSC2          0.3325383              0       0.000000       0.000000 #>          X45_Y-75..CD8T X47_Y-75..CD8T X46_Y-75..CD8T X47_Y-76..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          5.770386       1.235788       2.088098       3.401927 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       1.354731       1.036934       2.137961 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X46_Y-76..CD8T X45_Y-76..CD8T X48_Y-76..CD8T X47_Y-77..CD8T #> PDK4           0.000000        0.00000       0.000000       0.000000 #> TNFRSF17       0.000000        0.00000       0.000000       0.000000 #> ICAM3          3.099737        5.34116       3.722842       2.251754 #> FAP            0.000000        0.00000       0.000000       0.000000 #> GZMB           0.000000        0.00000       2.748807       1.512804 #> TSC2           0.000000        0.00000       0.000000       0.000000 #>          X45_Y-78..CD8T X46_Y-78..CD8T X48_Y-79..CD8T X47_Y-78..CD8T #> PDK4           0.000000       0.000000       0.000000              0 #> TNFRSF17       0.000000       0.000000       0.000000              0 #> ICAM3          2.573573       2.573573       2.207712              0 #> FAP            0.000000       0.000000       0.000000              0 #> GZMB           2.229899       2.229899       0.000000              0 #> TSC2           0.000000       0.000000       0.000000              0 #>          X77_Y-80..CD8T X76_Y-80..CD8T X78_Y-81..CD8T X78_Y-82..CD8T #> PDK4           0.000000              0        0.00000      0.0000000 #> TNFRSF17       0.000000              0        0.00000      0.0000000 #> ICAM3          5.012325              0        1.24047      1.2918651 #> FAP            0.000000              0        0.00000      0.0000000 #> GZMB           0.000000              0        1.24047      0.6202348 #> TSC2           0.000000              0        0.00000      0.0000000 #>          X78_Y-83..CD8T X77_Y-84..CD8T X75_Y-84..CD8T X75_Y-79..CD8T #> PDK4          0.0000000              0              0              0 #> TNFRSF17      0.0000000              0              0              0 #> ICAM3         1.8571313              0              0              0 #> FAP           0.0000000              0              0              0 #> GZMB          0.9995219              0              0              0 #> TSC2          0.0000000              0              0              0 #>          X77_Y-81..CD8T X77_Y-83..CD8T X72_Y-67..CD8T X78_Y-67..CD8T #> PDK4                  0       0.000000       0.000000       0.000000 #> TNFRSF17              0       0.000000       0.000000       0.000000 #> ICAM3                 0       2.223435       2.715443       2.762726 #> FAP                   0       0.000000       0.000000       0.000000 #> GZMB                  0       1.566950       0.000000       0.000000 #> TSC2                  0       0.000000       0.000000       0.000000 #>          X74_Y-67..CD8T X75_Y-67..CD8T X76_Y-68..CD8T X74_Y-68..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          3.383285       2.775336       2.780313       3.508941 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           3.153710       0.000000       2.941691       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X77_Y-68..CD8T X76_Y-69..CD8T X77_Y-69..CD8T X78_Y-69..CD8T #> PDK4                  0       0.000000              0              0 #> TNFRSF17              0       0.000000              0              0 #> ICAM3                 0       0.000000              0              0 #> FAP                   0       0.000000              0              0 #> GZMB                  0       2.569343              0              0 #> TSC2                  0       0.000000              0              0 #>          X74_Y-69..CD8T X75_Y-69..CD8T X78_Y-70..CD8T X74_Y-70..CD8T #> PDK4           0.000000       0.000000       0.000000        0.00000 #> TNFRSF17       0.000000       0.000000       0.000000        0.00000 #> ICAM3          1.895791       1.272347       1.308999        2.78642 #> FAP            0.000000       0.000000       0.000000        0.00000 #> GZMB           1.665870       0.000000       0.000000        0.00000 #> TSC2           0.000000       0.000000       0.000000        0.00000 #>          X74_Y-71..CD8T X77_Y-71..CD8T X78_Y-72..CD8T X77_Y-72..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          6.132899       4.858501       2.470424       3.239001 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           4.753095       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X76_Y-66..CD8T X75_Y-68..CD8T X57_Y-66..CD8T X58_Y-66..CD8T #> PDK4           0.000000      0.0000000       0.000000       0.000000 #> TNFRSF17       0.000000      0.0000000       0.000000       0.000000 #> ICAM3          5.226742      3.0951601       2.036917       2.679548 #> FAP            0.000000      0.0000000       0.000000       0.000000 #> GZMB           0.000000      0.7160465       2.502229       1.283725 #> TSC2           0.000000      0.0000000       0.000000       0.000000 #>          X58_Y-67..CD8T X59_Y-67..CD8T X56_Y-67..CD8T X57_Y-67..CD8T #> PDK4          0.0000000        0.00000       0.000000      0.0000000 #> TNFRSF17      0.0000000        0.00000       0.000000      0.0000000 #> ICAM3         1.9291124        2.71528       3.278579      2.8124996 #> FAP           0.0000000        0.00000       0.000000      0.0000000 #> GZMB          0.6981683        0.00000       0.000000      0.9831132 #> TSC2          0.0000000        0.00000       0.000000      0.0000000 #>          X60_Y-67..CD8T X57_Y-68..CD8T X60_Y-68..CD8T X58_Y-68..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          1.965913       2.687769       2.762516       1.301507 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       1.887273       0.000000       1.176897 #> TSC2           2.130847       0.000000       1.420565       0.000000 #>          X57_Y-69..CD8T X59_Y-69..CD8T X59_Y-70..CD8T X58_Y-70..CD8T #> PDK4          0.0000000      0.0000000       0.000000       0.000000 #> TNFRSF17      0.0000000      0.0000000       0.000000       0.000000 #> ICAM3         0.8564476      0.8229633       1.028704       4.663002 #> FAP           0.0000000      0.0000000       0.000000       0.000000 #> GZMB          1.3730471      0.8622388       0.000000       0.000000 #> TSC2          0.0000000      0.0000000       0.000000       0.000000 #>          X60_Y-71..CD8T X59_Y-71..CD8T X54_Y-68..CD8T X58_Y-69..CD8T #> PDK4                  0              0              0      0.0000000 #> TNFRSF17              0              0              0      0.0000000 #> ICAM3                 0              0              0      0.8564476 #> FAP                   0              0              0      0.0000000 #> GZMB                  0              0              0      2.0915794 #> TSC2                  0              0              0      0.0000000 #>          X57_Y-70..CD8T X60_Y-70..CD8T X58_Y-71..CD8T X43_Y-79..CD8T #> PDK4           0.000000              0       0.000000       0.000000 #> TNFRSF17       0.000000              0       0.000000       0.000000 #> ICAM3          4.663002              0       5.697193       4.363345 #> FAP            0.000000              0       0.000000       0.000000 #> GZMB           0.000000              0       0.000000       5.050104 #> TSC2           0.000000              0       0.000000       0.000000 #>          X47_Y-79..CD8T X45_Y-79..CD8T X46_Y-79..CD8T X47_Y-80..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.474852       4.502979       1.715716       1.754761 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       1.486600       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X45_Y-80..CD8T X46_Y-80..CD8T X46_Y-81..CD8T X45_Y-81..CD8T #> PDK4                  0      0.0000000      0.0000000       0.000000 #> TNFRSF17              0      0.0000000      0.0000000       0.000000 #> ICAM3                 0      2.7902989      3.6781488       2.331095 #> FAP                   0      0.0000000      0.0000000       0.000000 #> GZMB                  0      0.6726485      0.5504289       0.000000 #> TSC2                  0      0.0000000      0.0000000       0.000000 #>          X44_Y-81..CD8T X47_Y-81..CD8T X45_Y-82..CD8T X44_Y-82..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.338433       1.536039       2.760323       3.288513 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       1.565736       1.882359       1.592051 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X47_Y-82..CD8T X46_Y-82..CD8T X43_Y-82..CD8T X45_Y-83..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.260643       2.780489       2.388077       1.589603 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           1.788609       2.739967       2.388077       1.858139 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X43_Y-83..CD8T X46_Y-83..CD8T X44_Y-83..CD8T X44_Y-84..CD8T #> PDK4           0.000000      0.0000000       0.000000      0.0000000 #> TNFRSF17       0.000000      0.0000000       0.000000      0.0000000 #> ICAM3          1.910782      0.9733472       4.391410      3.1686804 #> FAP            0.000000      0.0000000       0.000000      0.0000000 #> GZMB           0.000000      3.1541527       1.212349      1.4528906 #> TSC2           0.000000      0.0000000       0.000000      0.4030235 #>          X45_Y-84..CD8T X46_Y-84..CD8T X43_Y-84..CD8T X47_Y-84..CD8T #> PDK4          0.0000000       0.000000      0.0000000       0.000000 #> TNFRSF17      0.0000000       0.000000      0.0000000       0.000000 #> ICAM3         0.6948307       2.403642      2.8443812       4.470883 #> FAP           0.0000000       0.000000      0.0000000       0.000000 #> GZMB          1.4920869       1.894971      0.0000000       2.034268 #> TSC2          0.0000000       0.000000      0.9672564       2.034268 #>          X45_Y-85..CD8T X46_Y-85..CD8T X44_Y-85..CD8T X44_Y-79..CD8T #> PDK4          0.0000000      0.0000000       0.000000       0.000000 #> TNFRSF17      0.0000000      0.0000000       0.000000       0.000000 #> ICAM3         1.3758694      1.6341596       1.508529       5.747799 #> FAP           0.0000000      0.0000000       0.000000       0.000000 #> GZMB          2.2163468      0.8070447       1.533803       0.000000 #> TSC2          0.3111072      0.0000000       0.000000       0.000000 #>          X47_Y-83..CD8T X47_Y-85..CD8T X48_Y-85..CD8T X55_Y-91..CD8T #> PDK4           0.000000       0.000000       0.000000      0.0000000 #> TNFRSF17       0.000000       0.000000       0.000000      0.0000000 #> ICAM3          1.555306       1.114950       1.812116      3.2962388 #> FAP            0.000000       0.000000       0.000000      0.0000000 #> GZMB           3.110612       2.249687       1.464110      0.7708453 #> TSC2           0.000000       0.000000       0.000000      0.0000000 #>          X50_Y-91..CD8T X49_Y-91..CD8T X51_Y-92..CD8T X52_Y-92..CD8T #> PDK4           0.000000       0.000000       0.000000        0.00000 #> TNFRSF17       0.000000       0.000000       0.000000        0.00000 #> ICAM3          2.723682       2.758973       3.255426        1.28892 #> FAP            0.000000       0.000000       0.000000        0.00000 #> GZMB           0.000000       0.000000       2.206654        0.00000 #> TSC2           0.000000       0.000000       0.000000        0.00000 #>          X53_Y-92..CD8T X50_Y-92..CD8T X49_Y-92..CD8T X53_Y-93..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.661704       3.418446       3.015213       4.128237 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       3.541145       1.599463       1.216147 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X48_Y-94..CD8T X53_Y-94..CD8T X51_Y-94..CD8T X54_Y-95..CD8T #> PDK4            0.00000              0       0.000000              0 #> TNFRSF17        0.00000              0       0.000000              0 #> ICAM3           3.94168              0       2.078606              0 #> FAP             0.00000              0       0.000000              0 #> GZMB            3.94168              0       0.000000              0 #> TSC2            0.00000              0       0.000000              0 #>          X53_Y-95..CD8T X52_Y-96..CD8T X51_Y-96..CD8T X49_Y-96..CD8T #> PDK4                  0       0.000000       0.000000       0.000000 #> TNFRSF17              0       0.000000       0.000000       0.000000 #> ICAM3                 0       2.723424       2.170326       0.000000 #> FAP                   0       0.000000       0.000000       0.000000 #> GZMB                  0       0.000000       0.000000       4.307573 #> TSC2                  0       0.000000       0.000000       0.000000 #>          X51_Y-97..CD8T X52_Y-93..CD8T X52_Y-95..CD8T X70_Y-79..CD8T #> PDK4           0.000000       0.000000              0       0.000000 #> TNFRSF17       0.000000       0.000000              0       0.000000 #> ICAM3          0.000000       1.750587              0       2.370420 #> FAP            0.000000       0.000000              0       0.000000 #> GZMB           5.089387       2.432293              0       1.778808 #> TSC2           0.000000       0.000000              0       0.000000 #>          X69_Y-79..CD8T X71_Y-80..CD8T X68_Y-80..CD8T X68_Y-81..CD8T #> PDK4           0.000000      0.0000000              0       0.000000 #> TNFRSF17       0.000000      0.0000000              0       0.000000 #> ICAM3          4.132759      1.5002671              0       1.849044 #> FAP            0.000000      0.0000000              0       0.000000 #> GZMB           5.220621      2.8086359              0       0.000000 #> TSC2           0.000000      0.7611375              0       0.000000 #>          X71_Y-81..CD8T X72_Y-82..CD8T X71_Y-82..CD8T X70_Y-83..CD8T #> PDK4          0.0000000              0       0.000000      0.0000000 #> TNFRSF17      0.0000000              0       0.000000      0.0000000 #> ICAM3         2.9065061              0       1.389577      3.1023242 #> FAP           0.0000000              0       0.000000      0.0000000 #> GZMB          2.7364451              0       0.000000      0.8289268 #> TSC2          0.7611375              0       0.000000      0.0000000 #>          X71_Y-83..CD8T X67_Y-83..CD8T X72_Y-83..CD8T X68_Y-83..CD8T #> PDK4           0.000000      0.0000000              0       0.000000 #> TNFRSF17       0.000000      0.0000000              0       0.000000 #> ICAM3          1.701849      3.6653027              0       2.941048 #> FAP            0.000000      0.0000000              0       0.000000 #> GZMB           0.000000      3.7975515              0       3.097077 #> TSC2           0.000000      0.4915409              0       1.454448 #>          X69_Y-84..CD8T X67_Y-84..CD8T X68_Y-84..CD8T X67_Y-85..CD8T #> PDK4          0.0000000      0.0000000       0.000000      0.0000000 #> TNFRSF17      0.0000000      0.0000000       0.000000      0.0000000 #> ICAM3         2.6770466      2.8938359       2.640429      0.9466345 #> FAP           0.0000000      0.0000000       0.000000      0.0000000 #> GZMB          0.9311093      2.9235222       2.604722      0.0000000 #> TSC2          0.0000000      0.5390712       0.000000      0.0000000 #>          X68_Y-85..CD8T X70_Y-80..CD8T X70_Y-84..CD8T X52_Y-67..CD8T #> PDK4          0.0000000       0.000000       0.000000      0.0000000 #> TNFRSF17      0.0000000       0.000000       0.000000      0.0000000 #> ICAM3         3.3722347       1.673255       2.808479      2.3628909 #> FAP           0.0000000       0.000000       0.000000      0.0000000 #> GZMB          0.6650781       1.980712       0.000000      0.7902942 #> TSC2          0.0000000       0.000000       0.000000      0.0000000 #>          X53_Y-67..CD8T X51_Y-67..CD8T X51_Y-68..CD8T X52_Y-68..CD8T #> PDK4                  0      0.0000000       0.000000       0.000000 #> TNFRSF17              0      0.0000000       0.000000       0.000000 #> ICAM3                 0      2.3383974       2.069306       3.621084 #> FAP                   0      0.0000000       0.000000       0.000000 #> GZMB                  0      0.5927206       0.000000       1.338587 #> TSC2                  0      0.0000000       0.000000       0.000000 #>          X49_Y-68..CD8T X51_Y-69..CD8T X52_Y-69..CD8T X50_Y-70..CD8T #> PDK4           0.000000      0.0000000       0.000000       0.000000 #> TNFRSF17       0.000000      0.0000000       0.000000       0.000000 #> ICAM3          4.913648      3.0705845       2.288216       2.699821 #> FAP            0.000000      0.0000000       0.000000       0.000000 #> GZMB           0.000000      0.7109218       1.485131       3.255025 #> TSC2           0.000000      0.0000000       0.000000       0.000000 #>          X52_Y-70..CD8T X51_Y-70..CD8T X49_Y-70..CD8T X53_Y-70..CD8T #> PDK4          0.0000000       0.000000       0.000000       0.000000 #> TNFRSF17      0.0000000       0.000000       0.000000       0.000000 #> ICAM3         0.5828149       2.139732       2.315204       2.004158 #> FAP           0.0000000       0.000000       0.000000       0.000000 #> GZMB          1.6758616       2.902072       1.284671       4.483961 #> TSC2          0.0000000       0.000000       0.000000       0.000000 #>          X48_Y-71..CD8T X52_Y-71..CD8T X51_Y-71..CD8T X49_Y-71..CD8T #> PDK4           0.000000      0.0000000      0.0000000       0.000000 #> TNFRSF17       0.000000      0.0000000      0.0000000       0.000000 #> ICAM3          2.197123      2.4309600      2.7650130       2.823799 #> FAP            0.000000      0.0000000      0.0000000       0.000000 #> GZMB           3.134463      1.2468594      1.6768192       4.063766 #> TSC2           0.000000      0.4140684      0.5520912       0.000000 #>          X52_Y-72..CD8T X53_Y-72..CD8T X51_Y-72..CD8T X50_Y-72..CD8T #> PDK4           0.000000       0.000000       0.000000              0 #> TNFRSF17       0.000000       0.000000       0.000000              0 #> ICAM3          2.730292       2.033394       1.588185              0 #> FAP            0.000000       0.000000       0.000000              0 #> GZMB           1.331154       1.694196       0.000000              0 #> TSC2           0.000000       0.000000       0.000000              0 #>          X50_Y-69..CD8T X48_Y-70..CD8T X63_Y-65..CD8T X64_Y-65..CD8T #> PDK4           0.000000      0.0000000       0.000000       0.000000 #> TNFRSF17       0.000000      0.0000000       0.000000       0.000000 #> ICAM3          1.599922      1.1513173       4.529834       2.004158 #> FAP            0.000000      0.0000000       0.000000       0.000000 #> GZMB           1.599922      0.9373394       0.000000       2.004158 #> TSC2           0.000000      0.0000000       0.000000       2.288148 #>          X65_Y-65..CD8T X66_Y-65..CD8T X64_Y-64..CD8T X56_Y-80..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          1.336105       1.850224       2.004158       2.520515 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           2.849089       0.000000       2.004158       1.123547 #> TSC2           0.000000       0.000000       2.288148       0.000000 #>          X59_Y-80..CD8T X58_Y-80..CD8T X55_Y-80..CD8T X57_Y-80..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          1.429890       3.030143       2.127412       3.479319 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           1.396223       0.000000       0.000000       1.209070 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X57_Y-81..CD8T X58_Y-81..CD8T X60_Y-81..CD8T X59_Y-81..CD8T #> PDK4           0.000000      0.0000000      0.0000000      0.0000000 #> TNFRSF17       0.000000      0.0000000      0.0000000      0.0000000 #> ICAM3          1.728092      1.5533851      2.3603774      2.2915501 #> FAP            0.000000      0.0000000      0.0000000      0.0000000 #> GZMB           1.834017      0.7595459      1.5571683      0.6415187 #> TSC2           0.000000      0.0000000      0.7759244      0.3103698 #>          X55_Y-81..CD8T X54_Y-81..CD8T X59_Y-82..CD8T X55_Y-82..CD8T #> PDK4           0.000000      0.0000000       0.000000       0.000000 #> TNFRSF17       0.000000      0.0000000       0.000000       0.000000 #> ICAM3          2.383321      0.7272242       3.697127       2.437488 #> FAP            0.000000      0.0000000       0.000000       0.000000 #> GZMB           1.387668      0.0000000       1.256816       1.210643 #> TSC2           0.000000      0.0000000       0.000000       0.000000 #>          X58_Y-82..CD8T X56_Y-82..CD8T X54_Y-82..CD8T X60_Y-82..CD8T #> PDK4          0.0000000       0.000000       0.000000              0 #> TNFRSF17      0.0000000       0.000000       0.000000              0 #> ICAM3         1.7116118       2.622667       2.921911              0 #> FAP           0.0000000       0.000000       0.000000              0 #> GZMB          0.5744395       0.000000       1.132774              0 #> TSC2          0.0000000       0.000000       0.000000              0 #>          X57_Y-82..CD8T X55_Y-83..CD8T X54_Y-83..CD8T X57_Y-83..CD8T #> PDK4                  0      0.0000000      0.0000000              0 #> TNFRSF17              0      0.0000000      0.0000000              0 #> ICAM3                 0      1.9893203      3.0971428              0 #> FAP                   0      0.0000000      0.0000000              0 #> GZMB                  0      0.6518137      0.5398094              0 #> TSC2                  0      0.0000000      0.5708532              0 #>          X58_Y-83..CD8T X55_Y-84..CD8T X58_Y-84..CD8T X57_Y-84..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          3.273628       2.161727       2.984325       2.131529 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           1.872224       0.874862       2.344149       2.655346 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X59_Y-84..CD8T X59_Y-85..CD8T X58_Y-85..CD8T X54_Y-85..CD8T #> PDK4          0.0000000      0.0000000        0.00000      0.0000000 #> TNFRSF17      0.0000000      0.0000000        0.00000      0.0000000 #> ICAM3         1.7602219      2.3594766        2.33273      1.1804230 #> FAP           0.0000000      0.0000000        0.00000      0.0000000 #> GZMB          1.7467514      2.4067236        1.10834      0.3268783 #> TSC2          0.3745314      0.2203126        0.00000      0.3191631 #>          X57_Y-85..CD8T X55_Y-85..CD8T X56_Y-85..CD8T X60_Y-85..CD8T #> PDK4           0.000000      0.0000000      0.0000000       0.000000 #> TNFRSF17       0.000000      0.0000000      0.0000000       0.000000 #> ICAM3          1.474908      1.4223983      2.7372745       3.267923 #> FAP            0.000000      0.0000000      0.0000000       0.000000 #> GZMB           1.842186      0.2664608      0.8057099       1.761261 #> TSC2           0.000000      0.2628402      0.0000000       0.000000 #>          X57_Y-79..CD8T X54_Y-80..CD8T X56_Y-83..CD8T X61_Y-81..CD8T #> PDK4           0.000000       0.000000              0              0 #> TNFRSF17       0.000000       0.000000              0              0 #> ICAM3          1.727245       1.721173              0              0 #> FAP            0.000000       0.000000              0              0 #> GZMB           2.981859       1.546650              0              0 #> TSC2           0.000000       0.000000              0              0 #>          X61_Y-82..CD8T X63_Y-82..CD8T X60_Y-83..CD8T X63_Y-83..CD8T #> PDK4            0.00000       0.000000       0.000000      0.0000000 #> TNFRSF17        0.00000       0.000000       0.000000      0.0000000 #> ICAM3           0.00000       1.407061       0.000000      1.6976798 #> FAP             0.00000       0.000000       0.000000      0.0000000 #> GZMB            5.24357       0.000000       2.225693      1.7241100 #> TSC2            0.00000       0.000000       0.000000      0.2544595 #>          X61_Y-83..CD8T X62_Y-83..CD8T X65_Y-83..CD8T X62_Y-84..CD8T #> PDK4           0.000000       0.000000       0.000000      0.0000000 #> TNFRSF17       0.000000       0.000000       0.000000      0.0000000 #> ICAM3          1.999907       2.610942       2.456824      1.7160673 #> FAP            0.000000       0.000000       0.000000      0.0000000 #> GZMB           2.752518       0.845581       2.586486      0.8614808 #> TSC2           0.000000       0.000000       0.000000      0.0000000 #>          X63_Y-84..CD8T X64_Y-84..CD8T X65_Y-84..CD8T X64_Y-85..CD8T #> PDK4          0.0000000      0.0000000      0.0000000       0.000000 #> TNFRSF17      0.0000000      0.0000000      0.0000000       0.000000 #> ICAM3         1.7092120      1.4252724      1.4333825       2.925904 #> FAP           0.0000000      0.0000000      0.0000000       0.000000 #> GZMB          0.9731571      0.2781762      0.6703018       0.000000 #> TSC2          0.2162906      0.2437103      0.2903302       0.000000 #>          X62_Y-85..CD8T X66_Y-85..CD8T X63_Y-85..CD8T X62_Y-82..CD8T #> PDK4            0.00000       0.000000       0.000000              0 #> TNFRSF17        0.00000       0.000000       0.000000              0 #> ICAM3           0.00000       1.386725       4.069315              0 #> FAP             0.00000       0.000000       0.000000              0 #> GZMB            1.05672       0.904150       0.000000              0 #> TSC2            0.00000       0.000000       0.000000              0 #>          X64_Y-82..CD8T X64_Y-83..CD8T X66_Y-84..CD8T X65_Y-85..CD8T #> PDK4           0.000000      0.0000000       0.000000      0.0000000 #> TNFRSF17       0.000000      0.0000000       0.000000      0.0000000 #> ICAM3          1.407061      1.6934696       1.593793      1.8988088 #> FAP            0.000000      0.0000000       0.000000      0.0000000 #> GZMB           0.000000      2.0017363       2.119575      1.0633323 #> TSC2           0.000000      0.8363652       0.000000      0.9290565 #>          X36_Y-92..CD8T X35_Y-93..CD8T X30_Y-94..CD8T X34_Y-96..CD8T #> PDK4           0.000000              0              0              0 #> TNFRSF17       0.000000              0              0              0 #> ICAM3          2.424381              0              0              0 #> FAP            0.000000              0              0              0 #> GZMB           0.000000              0              0              0 #> TSC2           0.000000              0              0              0 #>          X35_Y-92..CD8T X34_Y-93..CD8T X43_Y-85..CD8T X45_Y-86..CD8T #> PDK4           0.000000       0.000000       0.000000      0.0000000 #> TNFRSF17       0.000000       0.000000       0.000000      0.0000000 #> ICAM3          4.848761       6.179867       4.468283      2.8072228 #> FAP            0.000000       0.000000       0.000000      0.0000000 #> GZMB           0.000000       0.000000       0.000000      0.7466574 #> TSC2           0.000000       0.000000       0.000000      0.7466574 #>          X48_Y-86..CD8T X44_Y-86..CD8T X47_Y-86..CD8T X46_Y-86..CD8T #> PDK4           0.000000      0.0000000       0.000000       0.000000 #> TNFRSF17       0.000000      0.0000000       0.000000       0.000000 #> ICAM3          1.513427      0.8592801       1.588771       2.164622 #> FAP            0.000000      0.0000000       0.000000       0.000000 #> GZMB           1.124263      0.8941470       1.188906       1.837662 #> TSC2           0.000000      0.0000000       0.000000       0.000000 #>          X47_Y-87..CD8T X46_Y-87..CD8T X47_Y-88..CD8T X45_Y-88..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.150410       2.602777       1.743714       3.172723 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           1.803082       1.315073       1.018513       1.849195 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X48_Y-88..CD8T X46_Y-88..CD8T X43_Y-89..CD8T X47_Y-89..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.373356       2.576895       4.787888       2.506305 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           1.477229       0.873928       0.000000       0.000000 #> TSC2           0.324947       0.000000       0.000000       0.000000 #>          X46_Y-89..CD8T X48_Y-89..CD8T X45_Y-89..CD8T X47_Y-90..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.357729       2.098185       2.234309       1.964292 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       1.256192       0.000000       0.000000 #> TSC2           0.000000       0.000000       1.363358       0.000000 #>          X46_Y-90..CD8T X43_Y-90..CD8T X45_Y-90..CD8T X47_Y-91..CD8T #> PDK4          0.0000000       0.000000      0.0000000       0.000000 #> TNFRSF17      0.0000000       0.000000      0.0000000       0.000000 #> ICAM3         3.3121447       1.416001      3.4953013       3.491768 #> FAP           0.0000000       0.000000      0.0000000       0.000000 #> GZMB          0.4157211       0.000000      0.5196514       0.000000 #> TSC2          0.0000000       0.000000      0.0000000       0.000000 #>          X46_Y-91..CD8T X45_Y-87..CD8T X44_Y-89..CD8T X44_Y-90..CD8T #> PDK4            0.00000       0.000000       0.000000        0.00000 #> TNFRSF17        0.00000       0.000000       0.000000        0.00000 #> ICAM3           1.89538       2.882369       0.000000        5.95484 #> FAP             0.00000       0.000000       0.000000        0.00000 #> GZMB            0.00000       0.000000       0.000000        0.00000 #> TSC2            0.00000       0.000000       5.453431        0.00000 #>          X51_Y-79..CD8T X49_Y-80..CD8T X50_Y-80..CD8T X51_Y-80..CD8T #> PDK4           0.000000      0.0000000       0.000000      0.0000000 #> TNFRSF17       0.000000      0.0000000       0.000000      0.0000000 #> ICAM3          1.874862      2.1603075       2.106158      2.3850445 #> FAP            0.000000      0.0000000       0.000000      0.0000000 #> GZMB           2.322058      0.4378773       0.000000      0.8644401 #> TSC2           0.000000      0.3498060       0.000000      0.0000000 #>          X53_Y-80..CD8T X52_Y-80..CD8T X52_Y-81..CD8T X50_Y-81..CD8T #> PDK4             0.0000       0.000000       0.000000      0.0000000 #> TNFRSF17         0.0000       0.000000       0.000000      0.0000000 #> ICAM3            1.1691       1.295472       1.295472      1.8358534 #> FAP              0.0000       0.000000       0.000000      0.0000000 #> GZMB             0.0000       1.791804       1.791804      0.3586639 #> TSC2             0.0000       0.000000       0.000000      0.0000000 #>          X53_Y-81..CD8T X51_Y-81..CD8T X50_Y-82..CD8T X52_Y-82..CD8T #> PDK4           0.000000      0.0000000       0.000000       0.000000 #> TNFRSF17       0.000000      0.0000000       0.000000       0.000000 #> ICAM3          2.752725      1.8082843       4.358866       2.873336 #> FAP            0.000000      0.0000000       0.000000       0.000000 #> GZMB           0.000000      0.4843749       0.000000       1.051428 #> TSC2           0.000000      0.0000000       0.000000       0.000000 #>          X53_Y-82..CD8T X51_Y-82..CD8T X49_Y-82..CD8T X51_Y-83..CD8T #> PDK4           0.000000       0.000000       0.000000      0.0000000 #> TNFRSF17       0.000000       0.000000       0.000000      0.0000000 #> ICAM3          3.165961       3.300192       2.822176      1.4759059 #> FAP            0.000000       0.000000       0.000000      0.0000000 #> GZMB           0.000000       1.194726       0.000000      0.5256183 #> TSC2           0.000000       0.000000       0.000000      0.0000000 #>          X52_Y-83..CD8T X53_Y-84..CD8T X54_Y-84..CD8T X49_Y-84..CD8T #> PDK4           0.000000       0.000000      0.0000000       0.000000 #> TNFRSF17       0.000000       0.000000      0.0000000       0.000000 #> ICAM3          3.621239       2.130847      2.7080527       2.090693 #> FAP            0.000000       0.000000      0.0000000       0.000000 #> GZMB           0.000000       2.677175      0.3843472       1.025759 #> TSC2           0.000000       0.000000      0.4151659       0.000000 #>          X52_Y-84..CD8T X51_Y-84..CD8T X52_Y-85..CD8T X50_Y-85..CD8T #> PDK4           0.000000       0.000000      0.0000000       0.000000 #> TNFRSF17       0.000000       0.000000      0.0000000       0.000000 #> ICAM3          4.119759       3.234574      2.6496938       3.219811 #> FAP            0.000000       0.000000      0.0000000       0.000000 #> GZMB           0.000000       0.000000      0.2904758       1.607180 #> TSC2           0.000000       0.000000      0.0000000       0.000000 #>          X53_Y-85..CD8T X51_Y-85..CD8T X49_Y-85..CD8T X49_Y-81..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.955556       2.288920       3.325976       1.255145 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           1.064404       1.021386       1.749434       0.000000 #> TSC2           0.445484       0.000000       0.000000       0.000000 #>          X49_Y-83..CD8T X50_Y-84..CD8T X70_Y-91..CD8T X66_Y-91..CD8T #> PDK4           0.000000       0.000000       0.000000              0 #> TNFRSF17       0.000000       0.000000       0.000000              0 #> ICAM3          4.097200       1.779014       4.410381              0 #> FAP            0.000000       0.000000       0.000000              0 #> GZMB           4.782003       3.376939       4.410381              0 #> TSC2           0.000000       0.000000       0.000000              0 #>          X69_Y-93..CD8T X72_Y-93..CD8T X75_Y-91..CD8T X76_Y-92..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          4.861401       5.658486       5.929589       5.245334 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           4.861401       0.000000       0.000000       5.245334 #> TSC2           0.000000       0.000000       0.000000       5.245334 #>          X78_Y-92..CD8T X73_Y-93..CD8T X78_Y-93..CD8T X77_Y-93..CD8T #> PDK4           0.000000              0       0.000000       0.000000 #> TNFRSF17       0.000000              0       0.000000       0.000000 #> ICAM3          2.084836              0       1.389891       4.635125 #> FAP            0.000000              0       0.000000       0.000000 #> GZMB           0.000000              0       0.000000       5.323408 #> TSC2           0.000000              0       0.000000       0.000000 #>          X75_Y-94..CD8T X77_Y-95..CD8T X74_Y-96..CD8T X76_Y-96..CD8T #> PDK4           0.000000              0       0.000000         0.0000 #> TNFRSF17       0.000000              0       0.000000         0.0000 #> ICAM3          4.754651              0       5.155681         5.9172 #> FAP            0.000000              0       0.000000         0.0000 #> GZMB           0.000000              0       0.000000         0.0000 #> TSC2           0.000000              0       0.000000         0.0000 #>          X77_Y-96..CD8T X47_Y-69..CD8T X45_Y-69..CD8T X47_Y-70..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.443589       2.622667       5.081404       1.141706 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X46_Y-70..CD8T X45_Y-72..CD8T X48_Y-72..CD8T X47_Y-72..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          1.141706       5.057837       2.242739       3.040983 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       3.578498       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X46_Y-68..CD8T X73_Y-64..CD8T X74_Y-65..CD8T X73_Y-65..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          2.382278       3.242232       2.794589       3.250627 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       1.510126       1.338072       1.476509 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X74_Y-66..CD8T X72_Y-66..CD8T X24_Y-86..CD8T X27_Y-91..CD8T #> PDK4           0.000000       0.000000              0              0 #> TNFRSF17       0.000000       0.000000              0              0 #> ICAM3          2.040059       2.473667              0              0 #> FAP            0.000000       0.000000              0              0 #> GZMB           1.196356       0.000000              0              0 #> TSC2           0.000000       0.000000              0              0 #>          X27_Y-90..CD8T X33_Y-88..CD8T X38_Y-91..CD8T X42_Y-91..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          6.132899       5.408168       5.034617       5.097434 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       0.000000       4.410381 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X33_Y-100..CD8T X35_Y-100..CD8T X30_Y-102..CD8T X30_Y-103..CD8T #> PDK4            0.000000          0.0000        0.000000        0.000000 #> TNFRSF17        0.000000          0.0000        0.000000        0.000000 #> ICAM3           5.264283          4.9541        3.604498        4.536145 #> FAP             0.000000          0.0000        0.000000        0.000000 #> GZMB            0.000000          0.0000        1.038115        0.000000 #> TSC2            0.000000          0.0000        0.000000        0.000000 #>          X33_Y-103..CD8T X32_Y-103..CD8T X33_Y-104..CD8T X34_Y-100..CD8T #> PDK4           0.0000000               0        0.000000        0.000000 #> TNFRSF17       0.0000000               0        0.000000        0.000000 #> ICAM3          0.9854309               0        4.851533        5.269033 #> FAP            0.0000000               0        0.000000        0.000000 #> GZMB           0.0000000               0        0.000000        0.000000 #> TSC2           0.0000000               0        0.000000        0.000000 #>          X23_Y-104..CD8T X22_Y-103..CD8T X27_Y-98..CD8T X23_Y-99..CD8T #> PDK4            0.000000        0.000000              0       0.000000 #> TNFRSF17        0.000000        0.000000              0       0.000000 #> ICAM3           4.968821        4.848761              0       4.823959 #> FAP             0.000000        0.000000              0       0.000000 #> GZMB            0.000000        0.000000              0       0.000000 #> TSC2            0.000000        0.000000              0       0.000000 #>          X27_Y-101..CD8T X28_Y-101..CD8T X27_Y-102..CD8T X26_Y-103..CD8T #> PDK4                   0         0.00000        0.000000        0.000000 #> TNFRSF17               0         0.00000        0.000000        0.000000 #> ICAM3                  0         2.30756        5.323408        2.762726 #> FAP                    0         0.00000        0.000000        0.000000 #> GZMB                   0         0.00000        4.635125        0.000000 #> TSC2                   0         0.00000        0.000000        0.000000 #>          X77_Y-103..CD8T X77_Y-104..CD8T X78_Y-104..CD8T X73_Y-106..CD8T #> PDK4            0.000000        0.000000        0.000000        0.000000 #> TNFRSF17        0.000000        0.000000        0.000000        0.000000 #> ICAM3           0.000000        0.000000        4.625072        3.427243 #> FAP             0.000000        0.000000        0.000000        0.000000 #> GZMB            2.332959        0.000000        0.000000        0.000000 #> TSC2            2.278723        4.557445        0.000000        0.000000 #>          X76_Y-106..CD8T X63_Y-99..CD8T X61_Y-101..CD8T X64_Y-101..CD8T #> PDK4                   0              0        0.000000        0.000000 #> TNFRSF17               0              0        0.000000        0.000000 #> ICAM3                  0              0        3.530878        5.290126 #> FAP                    0              0        0.000000        0.000000 #> GZMB                   0              0        2.730166        4.201545 #> TSC2                   0              0        0.000000        0.000000 #>          X63_Y-101..CD8T X65_Y-101..CD8T X61_Y-102..CD8T X63_Y-102..CD8T #> PDK4            0.000000               0        0.000000       0.0000000 #> TNFRSF17        0.000000               0        0.000000       0.0000000 #> ICAM3           4.741765               0        2.713145       3.8779095 #> FAP             0.000000               0        0.000000       0.0000000 #> GZMB            0.000000               0        2.145825       0.9171717 #> TSC2            0.000000               0        0.000000       0.0000000 #>          X60_Y-102..CD8T X62_Y-102..CD8T X64_Y-103..CD8T X63_Y-103..CD8T #> PDK4            0.000000        0.000000        0.000000         0.00000 #> TNFRSF17        0.000000        0.000000        0.000000         0.00000 #> ICAM3           2.001511        4.838779        4.305215         1.99888 #> FAP             0.000000        0.000000        0.000000         0.00000 #> GZMB            0.000000        2.317563        0.000000         0.00000 #> TSC2            0.000000        0.000000        0.000000         0.00000 #>          X61_Y-103..CD8T X65_Y-103..CD8T X65_Y-104..CD8T X62_Y-101..CD8T #> PDK4            0.000000        0.000000        0.000000        0.000000 #> TNFRSF17        0.000000        0.000000        0.000000        0.000000 #> ICAM3           2.787588        5.343928        3.560894        5.177008 #> FAP             0.000000        0.000000        0.000000        0.000000 #> GZMB            1.588185        0.000000        1.147275        1.506933 #> TSC2            0.000000        0.000000        0.000000        0.000000 #>          X64_Y-102..CD8T X62_Y-103..CD8T X23_Y-105..CD8T X23_Y-106..CD8T #> PDK4                   0        0.000000        0.000000               0 #> TNFRSF17               0        0.000000        0.000000               0 #> ICAM3                  0        4.510081        1.595963               0 #> FAP                    0        0.000000        0.000000               0 #> GZMB                   0        1.158781        0.000000               0 #> TSC2                   0        0.000000        0.000000               0 #>          X22_Y-107..CD8T X69_Y-85..CD8T X66_Y-86..CD8T X69_Y-86..CD8T #> PDK4            0.000000       0.000000       0.000000       0.000000 #> TNFRSF17        0.000000       0.000000       0.000000       0.000000 #> ICAM3           5.658486       4.990139       1.920446       4.787888 #> FAP             0.000000       0.000000       0.000000       0.000000 #> GZMB            0.000000       0.000000       0.000000       0.000000 #> TSC2            0.000000       0.000000       0.000000       0.000000 #>          X67_Y-86..CD8T X68_Y-87..CD8T X72_Y-87..CD8T X67_Y-87..CD8T #> PDK4           0.000000       0.000000              0       0.000000 #> TNFRSF17       0.000000       0.000000              0       0.000000 #> ICAM3          4.525400       5.791852              0       4.724259 #> FAP            0.000000       0.000000              0       0.000000 #> GZMB           0.000000       0.000000              0       0.000000 #> TSC2           2.269476       0.000000              0       1.512984 #>          X69_Y-88..CD8T X71_Y-88..CD8T X72_Y-90..CD8T X70_Y-90..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          5.089419       5.747799       1.961036       5.974209 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           2.197225       0.000000       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X73_Y-91..CD8T X68_Y-86..CD8T X72_Y-86..CD8T X67_Y-89..CD8T #> PDK4                  0       0.000000              0       0.000000 #> TNFRSF17              0       0.000000              0       0.000000 #> ICAM3                 0       5.272503              0       1.696462 #> FAP                   0       0.000000              0       0.000000 #> GZMB                  0       0.000000              0       1.696462 #> TSC2                  0       0.000000              0       0.000000 #>          X28_Y-104..CD8T X25_Y-105..CD8T X24_Y-105..CD8T X24_Y-106..CD8T #> PDK4            0.000000        0.000000               0        0.000000 #> TNFRSF17        0.000000        0.000000               0        0.000000 #> ICAM3           5.050104        2.952722               0        2.359745 #> FAP             0.000000        0.000000               0        0.000000 #> GZMB            0.000000        0.000000               0        0.000000 #> TSC2            0.000000        0.000000               0        2.359745 #>          X25_Y-106..CD8T X26_Y-106..CD8T X26_Y-107..CD8T X28_Y-107..CD8T #> PDK4            0.000000         0.00000         0.00000               0 #> TNFRSF17        0.000000         0.00000         0.00000               0 #> ICAM3           5.361098         2.46331         2.46331               0 #> FAP             0.000000         0.00000         0.00000               0 #> GZMB            0.000000         0.00000         0.00000               0 #> TSC2            0.000000         0.00000         0.00000               0 #>          X73_Y-98..CD8T X68_Y-102..CD8T X68_Y-104..CD8T X66_Y-104..CD8T #> PDK4           0.000000               0        0.000000        0.000000 #> TNFRSF17       0.000000               0        0.000000        0.000000 #> ICAM3          4.874205               0        4.635125        5.190573 #> FAP            0.000000               0        0.000000        0.000000 #> GZMB           0.000000               0        5.323408        0.000000 #> TSC2           0.000000               0        0.000000        0.000000 #>          X70_Y-105..CD8T X71_Y-105..CD8T X67_Y-105..CD8T X68_Y-106..CD8T #> PDK4            0.000000       0.0000000        0.000000        0.000000 #> TNFRSF17        0.000000       0.0000000        0.000000        0.000000 #> ICAM3           4.587305       2.7324445        2.595287        0.000000 #> FAP             0.000000       0.0000000        0.000000        0.000000 #> GZMB            0.000000       0.0000000        0.000000        2.338201 #> TSC2            0.000000       0.8988378        0.000000        0.000000 #>          X71_Y-106..CD8T X70_Y-104..CD8T X68_Y-105..CD8T X70_Y-106..CD8T #> PDK4            0.000000        0.000000               0        0.000000 #> TNFRSF17        0.000000        0.000000               0        0.000000 #> ICAM3           4.351536        4.624126               0        4.913648 #> FAP             0.000000        0.000000               0        0.000000 #> GZMB            2.025715        0.000000               0        0.000000 #> TSC2            0.000000        0.000000               0        0.000000 #>          X57_Y-104..CD8T X55_Y-104..CD8T X59_Y-104..CD8T X58_Y-104..CD8T #> PDK4            0.000000        0.000000        0.000000        0.000000 #> TNFRSF17        0.000000        0.000000        0.000000        0.000000 #> ICAM3           1.087039        3.424788        2.436279        2.042729 #> FAP             0.000000        0.000000        0.000000        0.000000 #> GZMB            1.316071        0.000000        1.269158        3.676378 #> TSC2            0.000000        1.132458        0.000000        0.000000 #>          X54_Y-104..CD8T X59_Y-105..CD8T X60_Y-105..CD8T X57_Y-105..CD8T #> PDK4            0.000000        0.000000        0.000000        0.000000 #> TNFRSF17        0.000000        0.000000        0.000000        0.000000 #> ICAM3           5.014032        2.323662        5.747799        2.210220 #> FAP             0.000000        0.000000        0.000000        0.000000 #> GZMB            1.151317        1.330505        0.000000        1.773897 #> TSC2            1.132458        0.000000        0.000000        0.000000 #>          X58_Y-105..CD8T X55_Y-106..CD8T X54_Y-106..CD8T X59_Y-106..CD8T #> PDK4           0.0000000       0.0000000       0.0000000        0.000000 #> TNFRSF17       0.0000000       0.0000000       0.0000000        0.000000 #> ICAM3          1.3215920       0.7810725       1.2681636        2.083457 #> FAP            0.0000000       0.0000000       0.0000000        0.000000 #> GZMB           2.1308523       0.8526187       0.5913206        2.958706 #> TSC2           0.6726485       0.3837724       0.0000000        0.000000 #>          X56_Y-106..CD8T X57_Y-106..CD8T X54_Y-107..CD8T X55_Y-107..CD8T #> PDK4           0.0000000        0.000000       0.0000000       0.0000000 #> TNFRSF17       0.0000000        0.000000       0.0000000       0.0000000 #> ICAM3          1.6154075        3.131085       2.7144880       2.7651569 #> FAP            0.0000000        0.000000       0.0000000       0.0000000 #> GZMB           0.5628478        1.717709       0.6458286       0.4739053 #> TSC2           0.9965127        0.000000       0.0000000       0.0000000 #>          X56_Y-104..CD8T X55_Y-105..CD8T X56_Y-105..CD8T X58_Y-106..CD8T #> PDK4            0.000000         0.00000               0        0.000000 #> TNFRSF17        0.000000         0.00000               0        0.000000 #> ICAM3           2.006819         1.52862               0        2.934565 #> FAP             0.000000         0.00000               0        0.000000 #> GZMB            0.000000         0.00000               0        4.897960 #> TSC2            0.000000         0.00000               0        0.000000 #>          X56_Y-107..CD8T X57_Y-107..CD8T X64_Y-104..CD8T X61_Y-104..CD8T #> PDK4           0.0000000        0.000000        0.000000        0.000000 #> TNFRSF17       0.0000000        0.000000        0.000000        0.000000 #> ICAM3          3.3984732        0.000000        3.839446        4.676402 #> FAP            0.0000000        0.000000        0.000000        0.000000 #> GZMB           1.5551297        5.612132        0.996622        4.676402 #> TSC2           0.7272242        0.000000        0.000000        0.000000 #>          X65_Y-105..CD8T X62_Y-105..CD8T X64_Y-105..CD8T X62_Y-106..CD8T #> PDK4            0.000000        0.000000               0        0.000000 #> TNFRSF17        0.000000        0.000000               0        0.000000 #> ICAM3           1.906253        1.687675               0        2.281482 #> FAP             0.000000        0.000000               0        0.000000 #> GZMB            1.835639        2.013298               0        4.096881 #> TSC2            0.000000        0.000000               0        0.000000 #>          X61_Y-106..CD8T X64_Y-106..CD8T X63_Y-106..CD8T X66_Y-107..CD8T #> PDK4            0.000000               0        0.000000         0.00000 #> TNFRSF17        0.000000               0        0.000000         0.00000 #> ICAM3           1.459591               0        0.000000         2.11391 #> FAP             0.000000               0        0.000000         0.00000 #> GZMB            2.800854               0        1.730191         0.00000 #> TSC2            0.000000               0        0.000000         0.00000 #>          X67_Y-107..CD8T X63_Y-104..CD8T X61_Y-107..CD8T X64_Y-107..CD8T #> PDK4             0.00000        0.000000        0.000000        0.000000 #> TNFRSF17         0.00000        0.000000        0.000000        0.000000 #> ICAM3            4.22782        3.346982        2.201191        3.879363 #> FAP              0.00000        0.000000        0.000000        0.000000 #> GZMB             0.00000        1.661037        1.967140        0.000000 #> TSC2             0.00000        0.000000        0.000000        0.000000 #>          X49_Y-103..CD8T X49_Y-104..CD8T X48_Y-104..CD8T X52_Y-105..CD8T #> PDK4            0.000000        0.000000        0.000000        0.000000 #> TNFRSF17        0.000000        0.000000        0.000000        0.000000 #> ICAM3           1.486600        0.000000        0.000000        2.760200 #> FAP             0.000000        0.000000        0.000000        0.000000 #> GZMB            1.715716        0.000000        0.000000        1.226856 #> TSC2            0.000000        1.284671        2.569343        0.000000 #>          X53_Y-105..CD8T X54_Y-105..CD8T X51_Y-106..CD8T X48_Y-107..CD8T #> PDK4           0.0000000       0.0000000       0.0000000        0.000000 #> TNFRSF17       0.0000000       0.0000000       0.0000000        0.000000 #> ICAM3          0.6248929       3.3482422       0.9827296        2.459723 #> FAP            0.0000000       0.0000000       0.0000000        0.000000 #> GZMB           0.7125970       1.9526771       1.6383472        2.549121 #> TSC2           0.0000000       0.6471191       0.0000000        0.000000 #>          X53_Y-107..CD8T X50_Y-107..CD8T X50_Y-103..CD8T X51_Y-104..CD8T #> PDK4            0.000000        0.000000        0.000000        0.000000 #> TNFRSF17        0.000000        0.000000        0.000000        0.000000 #> ICAM3           1.580588        2.582144        1.634674        1.225109 #> FAP             0.000000        0.000000        0.000000        0.000000 #> GZMB            1.489428        4.675524        3.052975        2.844962 #> TSC2            0.000000        0.000000        0.000000        0.000000 #>          X52_Y-106..CD8T X31_Y-104..CD8T X30_Y-107..CD8T X31_Y-103..CD8T #> PDK4             0.00000        0.000000          0.0000               0 #> TNFRSF17         0.00000        0.000000          0.0000               0 #> ICAM3            4.18867        1.110762          4.0462               0 #> FAP              0.00000        0.000000          0.0000               0 #> GZMB             0.00000        0.000000          0.0000               0 #> TSC2             0.00000        0.000000          0.0000               0 #>          X42_Y-103..CD8T X43_Y-105..CD8T X42_Y-106..CD8T X46_Y-106..CD8T #> PDK4            0.000000        0.000000       0.0000000        0.000000 #> TNFRSF17        0.000000        0.000000       0.0000000        0.000000 #> ICAM3           1.964449        1.852899       1.9916756        3.603166 #> FAP             0.000000        0.000000       0.0000000        0.000000 #> GZMB            0.000000        4.688457       0.0000000        0.000000 #> TSC2            0.000000        0.000000       0.9245222        0.000000 #>          X44_Y-106..CD8T X43_Y-107..CD8T X42_Y-107..CD8T X45_Y-107..CD8T #> PDK4            0.000000        0.000000        0.000000        0.000000 #> TNFRSF17        0.000000        0.000000        0.000000        0.000000 #> ICAM3           2.391002        0.000000        2.705202        4.351933 #> FAP             0.000000        0.000000        0.000000        0.000000 #> GZMB            2.418141        4.836282        1.308979        0.000000 #> TSC2            0.000000        0.000000        0.000000        0.000000 #>          X47_Y-107..CD8T X47_Y-105..CD8T X56_Y-98..CD8T X59_Y-98..CD8T #> PDK4            0.000000               0      0.0000000       0.000000 #> TNFRSF17        0.000000               0      0.0000000       0.000000 #> ICAM3           2.283413               0      3.1912723       1.422871 #> FAP             0.000000               0      0.0000000       0.000000 #> GZMB            2.283413               0      1.9189710       0.000000 #> TSC2            0.000000               0      0.4727583       0.000000 #>          X57_Y-98..CD8T X59_Y-99..CD8T X55_Y-99..CD8T X56_Y-99..CD8T #> PDK4           0.000000       0.000000      0.0000000      0.0000000 #> TNFRSF17       0.000000       0.000000      0.0000000      0.0000000 #> ICAM3          2.578708       4.268613      2.3586976      4.0403501 #> FAP            0.000000       0.000000      0.0000000      0.0000000 #> GZMB           1.387668       0.000000      0.5303305      2.3887799 #> TSC2           0.000000       0.000000      0.0000000      0.7091374 #>          X54_Y-100..CD8T X60_Y-100..CD8T X60_Y-101..CD8T X56_Y-101..CD8T #> PDK4            0.000000               0        0.000000        0.000000 #> TNFRSF17        0.000000               0        0.000000        0.000000 #> ICAM3           1.759156               0        1.995124        5.430541 #> FAP             0.000000               0        0.000000        0.000000 #> GZMB            1.269596               0        1.993058        4.340652 #> TSC2            0.000000               0        0.000000        0.000000 #>          X58_Y-102..CD8T X57_Y-102..CD8T X59_Y-103..CD8T X57_Y-103..CD8T #> PDK4            0.000000        0.000000        0.000000        0.000000 #> TNFRSF17        0.000000        0.000000        0.000000        0.000000 #> ICAM3           4.950236        4.621207        2.528918        3.951636 #> FAP             0.000000        0.000000        0.000000        0.000000 #> GZMB            0.000000        0.000000        0.000000        0.000000 #> TSC2            0.000000        0.000000        0.000000        0.000000 #>          X54_Y-98..CD8T X54_Y-99..CD8T X57_Y-100..CD8T X55_Y-100..CD8T #> PDK4           0.000000       0.000000         0.00000       0.0000000 #> TNFRSF17       0.000000       0.000000         0.00000       0.0000000 #> ICAM3          4.626574       2.423956         5.50899       2.0525876 #> FAP            0.000000       0.000000         0.00000       0.0000000 #> GZMB           1.603929       0.000000         0.00000       0.6458286 #> TSC2           0.000000       0.000000         0.00000       0.0000000 #>          X38_Y-100..CD8T X41_Y-101..CD8T X42_Y-102..CD8T X41_Y-102..CD8T #> PDK4                   0        0.000000        0.000000        0.000000 #> TNFRSF17               0        0.000000        0.000000        0.000000 #> ICAM3                  0        2.599929        3.584065        3.484495 #> FAP                    0        0.000000        0.000000        0.000000 #> GZMB                   0        1.276387        0.000000        0.000000 #> TSC2                   0        0.000000        0.000000        0.000000 #>          X41_Y-103..CD8T X61_Y-85..CD8T X63_Y-86..CD8T X62_Y-86..CD8T #> PDK4            0.000000       0.000000       0.000000      0.0000000 #> TNFRSF17        0.000000       0.000000       0.000000      0.0000000 #> ICAM3           1.754761       2.350389       4.692095      1.5087497 #> FAP             0.000000       0.000000       0.000000      0.0000000 #> GZMB            0.000000       0.000000       0.000000      0.9957014 #> TSC2            0.000000       0.000000       0.000000      0.0000000 #>          X61_Y-86..CD8T X65_Y-86..CD8T X61_Y-87..CD8T X60_Y-87..CD8T #> PDK4          0.0000000       0.000000       0.000000       0.000000 #> TNFRSF17      0.0000000       0.000000       0.000000       0.000000 #> ICAM3         2.7134637       4.840886       2.498489       1.230095 #> FAP           0.0000000       0.000000       0.000000       0.000000 #> GZMB          0.9895535       0.000000       1.904691       1.104611 #> TSC2          0.0000000       0.000000       0.000000       0.000000 #>          X62_Y-87..CD8T X63_Y-87..CD8T X62_Y-88..CD8T X62_Y-89..CD8T #> PDK4          0.0000000       0.000000       0.000000       0.000000 #> TNFRSF17      0.0000000       0.000000       0.000000       0.000000 #> ICAM3         1.8478400       4.635125       1.096645       2.187626 #> FAP           0.0000000       0.000000       0.000000       0.000000 #> GZMB          1.1407125       0.000000       0.000000       0.880152 #> TSC2          0.5606847       0.000000       1.121369       0.000000 #>          X64_Y-89..CD8T X66_Y-89..CD8T X61_Y-89..CD8T X63_Y-89..CD8T #> PDK4           0.000000              0       0.000000      0.0000000 #> TNFRSF17       0.000000              0       0.000000      0.0000000 #> ICAM3          2.411979              0       1.786822      3.9560522 #> FAP            0.000000              0       0.000000      0.0000000 #> GZMB           0.000000              0       2.163472      0.7365258 #> TSC2           0.000000              0       0.000000      0.0000000 #>          X62_Y-90..CD8T X61_Y-90..CD8T X64_Y-90..CD8T X63_Y-90..CD8T #> PDK4           0.000000      0.0000000       0.000000       0.000000 #> TNFRSF17       0.000000      0.0000000       0.000000       0.000000 #> ICAM3          3.011852      4.4174895       2.651652       4.743470 #> FAP            0.000000      0.0000000       0.000000       0.000000 #> GZMB           2.156485      0.3951471       0.000000       1.031136 #> TSC2           0.000000      0.0000000       2.651652       0.000000 #>          X65_Y-90..CD8T X60_Y-91..CD8T X64_Y-86..CD8T X63_Y-91..CD8T #> PDK4                  0      0.0000000       0.000000       0.000000 #> TNFRSF17              0      0.0000000       0.000000       0.000000 #> ICAM3                 0      1.1484035       4.625072       1.531839 #> FAP                   0      0.0000000       0.000000       0.000000 #> GZMB                  0      0.6228888       0.000000       3.029600 #> TSC2                  0      0.0000000       0.000000       0.000000 #>          X36_Y-93..CD8T X38_Y-94..CD8T X40_Y-94..CD8T X39_Y-96..CD8T #> PDK4                  0       0.000000       0.000000       0.000000 #> TNFRSF17              0       0.000000       0.000000       0.000000 #> ICAM3                 0       2.137791       4.214594       4.571217 #> FAP                   0       0.000000       0.000000       0.000000 #> GZMB                  0       2.544693       0.000000       0.000000 #> TSC2                  0       0.000000       0.000000       0.000000 #>          X41_Y-97..CD8T X40_Y-93..CD8T X39_Y-95..CD8T X42_Y-96..CD8T #> PDK4           0.000000       0.000000              0              0 #> TNFRSF17       0.000000       0.000000              0              0 #> ICAM3          5.935842       4.874205              0              0 #> FAP            0.000000       0.000000              0              0 #> GZMB           0.000000       4.188670              0              0 #> TSC2           0.000000       0.000000              0              0 #>          X41_Y-96..CD8T X41_Y-104..CD8T X40_Y-105..CD8T X41_Y-106..CD8T #> PDK4           0.000000        0.000000        0.000000       0.0000000 #> TNFRSF17       0.000000        0.000000        0.000000       0.0000000 #> ICAM3          3.756486        4.874205        4.954735       2.3228422 #> FAP            0.000000        0.000000        0.000000       0.0000000 #> GZMB           0.000000        0.000000        2.477368       0.7595742 #> TSC2           0.000000        0.000000        0.000000       0.0000000 #>          X40_Y-106..CD8T X41_Y-107..CD8T X41_Y-105..CD8T X40_Y-107..CD8T #> PDK4            0.000000       0.0000000        0.000000        0.000000 #> TNFRSF17        0.000000       0.0000000        0.000000        0.000000 #> ICAM3           1.277749       2.5353918        3.170727        3.350614 #> FAP             0.000000       0.0000000        0.000000        0.000000 #> GZMB            0.000000       0.6544894        3.175422        0.000000 #> TSC2            0.000000       0.8509247        0.000000        0.000000 #>          X53_Y-86..CD8T X50_Y-86..CD8T X54_Y-86..CD8T X51_Y-86..CD8T #> PDK4          0.0000000      0.0000000       0.000000      0.0000000 #> TNFRSF17      0.0000000      0.0000000       0.000000      0.0000000 #> ICAM3         2.5466688      1.9946733       3.305990      3.2606664 #> FAP           0.0000000      0.0000000       0.000000      0.0000000 #> GZMB          0.8156533      0.5023111       1.736874      0.5696807 #> TSC2          0.0000000      0.0000000       0.000000      0.0000000 #>          X49_Y-86..CD8T X52_Y-86..CD8T X54_Y-87..CD8T X52_Y-87..CD8T #> PDK4           0.000000       0.000000      0.0000000       0.000000 #> TNFRSF17       0.000000       0.000000      0.0000000       0.000000 #> ICAM3          1.116313       2.357539      2.4793185       2.454733 #> FAP            0.000000       0.000000      0.0000000       0.000000 #> GZMB           2.732567       0.000000      0.8665649       1.149263 #> TSC2           0.000000       0.000000      0.0000000       0.000000 #>          X53_Y-87..CD8T X51_Y-87..CD8T X50_Y-87..CD8T X55_Y-87..CD8T #> PDK4           0.000000      0.0000000       0.000000      0.0000000 #> TNFRSF17       0.000000      0.0000000       0.000000      0.0000000 #> ICAM3          3.732583      1.5635845       3.157049      2.0320291 #> FAP            0.000000      0.0000000       0.000000      0.0000000 #> GZMB           0.000000      0.3303623       0.000000      0.9895394 #> TSC2           0.000000      0.0000000       0.000000      0.0000000 #>          X51_Y-88..CD8T X49_Y-88..CD8T X52_Y-88..CD8T X50_Y-88..CD8T #> PDK4           0.000000      0.0000000      0.0000000      0.0000000 #> TNFRSF17       0.000000      0.0000000      0.0000000      0.0000000 #> ICAM3          1.964094      1.5206385      3.1038628      2.5882922 #> FAP            0.000000      0.0000000      0.0000000      0.0000000 #> GZMB           0.000000      0.0000000      0.8332802      0.5672831 #> TSC2           0.000000      0.4061838      0.0000000      0.4165953 #>          X53_Y-88..CD8T X54_Y-88..CD8T X51_Y-89..CD8T X50_Y-89..CD8T #> PDK4           0.000000      0.0000000      0.0000000      0.0000000 #> TNFRSF17       0.000000      0.0000000      0.0000000      0.0000000 #> ICAM3          2.831499      3.3646137      1.7699481      2.4294955 #> FAP            0.000000      0.0000000      0.0000000      0.0000000 #> GZMB           0.000000      0.7559861      0.8939245      1.4348636 #> TSC2           0.000000      0.0000000      0.0000000      0.7829516 #>          X53_Y-89..CD8T X49_Y-89..CD8T X54_Y-89..CD8T X52_Y-89..CD8T #> PDK4           0.000000       0.000000      0.0000000      0.0000000 #> TNFRSF17       0.000000       0.000000      0.0000000      0.0000000 #> ICAM3          2.490898       2.954208      2.3777906      2.6157568 #> FAP            0.000000       0.000000      0.0000000      0.0000000 #> GZMB           0.000000       1.220016      0.5463786      0.9932495 #> TSC2           0.000000       0.000000      0.0000000      0.0000000 #>          X51_Y-90..CD8T X52_Y-90..CD8T X50_Y-90..CD8T X54_Y-90..CD8T #> PDK4          0.0000000       0.000000      0.0000000      0.0000000 #> TNFRSF17      0.0000000       0.000000      0.0000000      0.0000000 #> ICAM3         1.6801167       2.276192      3.3041317      1.9021014 #> FAP           0.0000000       0.000000      0.0000000      0.0000000 #> GZMB          0.8836891       1.417228      0.0000000      0.7853872 #> TSC2          0.0000000       0.000000      0.7829516      0.0000000 #>          X49_Y-90..CD8T X48_Y-90..CD8T X51_Y-91..CD8T X54_Y-91..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          3.752339       3.691567       4.555484       1.629059 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       2.775001       0.000000       0.000000 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X49_Y-87..CD8T X52_Y-91..CD8T X55_Y-86..CD8T X58_Y-86..CD8T #> PDK4           0.000000              0      0.0000000       0.000000 #> TNFRSF17       0.000000              0      0.0000000       0.000000 #> ICAM3          2.054943              0      2.2399314       2.370629 #> FAP            0.000000              0      0.0000000       0.000000 #> GZMB           0.000000              0      0.4855622       1.079017 #> TSC2           0.000000              0      0.2019423       0.258369 #>          X56_Y-86..CD8T X59_Y-86..CD8T X57_Y-86..CD8T X60_Y-86..CD8T #> PDK4          0.0000000       0.000000      0.0000000       0.000000 #> TNFRSF17      0.0000000       0.000000      0.0000000       0.000000 #> ICAM3         1.9868697       1.414461      1.8989400       4.695632 #> FAP           0.0000000       0.000000      0.0000000       0.000000 #> GZMB          0.0000000       1.569088      0.7079074       1.346899 #> TSC2          0.9513777       0.000000      0.2540314       0.000000 #>          X57_Y-87..CD8T X58_Y-87..CD8T X59_Y-87..CD8T X56_Y-87..CD8T #> PDK4          0.0000000      0.0000000      0.0000000      0.0000000 #> TNFRSF17      0.0000000      0.0000000      0.0000000      0.0000000 #> ICAM3         2.5933144      3.0410020      3.1316414      0.6578956 #> FAP           0.0000000      0.0000000      0.0000000      0.0000000 #> GZMB          0.0000000      0.3542515      0.9933893      0.6742129 #> TSC2          0.3255318      0.3505727      0.0000000      1.9040665 #>          X58_Y-88..CD8T X57_Y-88..CD8T X59_Y-88..CD8T X55_Y-88..CD8T #> PDK4           0.000000      0.0000000       0.000000      0.0000000 #> TNFRSF17       0.000000      0.0000000       0.000000      0.0000000 #> ICAM3          1.724694      2.1929030       2.319389      2.7985833 #> FAP            0.000000      0.0000000       0.000000      0.0000000 #> GZMB           0.667991      0.3817091       2.824297      0.4943154 #> TSC2           0.000000      0.2735443       0.000000      0.2531745 #>          X56_Y-88..CD8T X55_Y-89..CD8T X59_Y-89..CD8T X58_Y-89..CD8T #> PDK4           0.000000      0.0000000       0.000000       0.000000 #> TNFRSF17       0.000000      0.0000000       0.000000       0.000000 #> ICAM3          1.894707      2.5732807       2.061679       2.911906 #> FAP            0.000000      0.0000000       0.000000       0.000000 #> GZMB           1.038720      0.5702217       3.017911       3.968168 #> TSC2           0.000000      0.2869311       0.000000       0.000000 #>          X56_Y-89..CD8T X57_Y-89..CD8T X60_Y-89..CD8T X59_Y-90..CD8T #> PDK4          0.0000000       0.000000      0.0000000      0.0000000 #> TNFRSF17      0.0000000       0.000000      0.0000000      0.0000000 #> ICAM3         3.2368737       1.754483      1.3542150      1.1884005 #> FAP           0.0000000       0.000000      0.0000000      0.0000000 #> GZMB          0.5227870       1.908738      0.6524036      0.8380497 #> TSC2          0.6176061       0.000000      0.0000000      0.3951471 #>          X56_Y-90..CD8T X60_Y-90..CD8T X58_Y-90..CD8T X57_Y-90..CD8T #> PDK4           0.000000      0.0000000      0.0000000       0.000000 #> TNFRSF17       0.000000      0.0000000      0.0000000       0.000000 #> ICAM3          3.591725      1.1412379      2.7274601       2.361668 #> FAP            0.000000      0.0000000      0.0000000       0.000000 #> GZMB           1.836751      0.4152592      2.2952125       0.555290 #> TSC2           0.449168      0.0000000      0.6847378       0.000000 #>          X55_Y-90..CD8T X56_Y-91..CD8T X57_Y-64..CD8T X55_Y-65..CD8T #> PDK4          0.0000000       0.000000        0.00000      0.0000000 #> TNFRSF17      0.0000000       0.000000        0.00000      0.0000000 #> ICAM3         2.3622212       4.862580        4.80661      2.3031323 #> FAP           0.0000000       0.000000        0.00000      0.0000000 #> GZMB          0.7708453       2.684107        0.00000      0.5714436 #> TSC2          0.6689396       0.000000        0.00000      0.0000000 #>          X57_Y-65..CD8T X56_Y-65..CD8T X59_Y-65..CD8T X58_Y-65..CD8T #> PDK4           0.000000       0.000000              0       0.000000 #> TNFRSF17       0.000000       0.000000              0       0.000000 #> ICAM3          2.377696       2.173268              0       3.672643 #> FAP            0.000000       0.000000              0       0.000000 #> GZMB           3.883683       1.268206              0       0.000000 #> TSC2           0.000000       0.000000              0       0.000000 #>          X55_Y-66..CD8T X55_Y-64..CD8T X56_Y-66..CD8T X59_Y-66..CD8T #> PDK4          0.0000000      0.0000000       0.000000       0.000000 #> TNFRSF17      0.0000000      0.0000000       0.000000       0.000000 #> ICAM3         4.0281344      1.9375535       2.162236       1.464816 #> FAP           0.0000000      0.0000000       0.000000       0.000000 #> GZMB          0.7098315      0.4571549       2.015823       3.383820 #> TSC2          0.0000000      0.0000000       0.000000       0.000000 #>          X72_Y-64..CD8T X72_Y-65..CD8T X70_Y-65..CD8T X71_Y-65..CD8T #> PDK4                  0        0.00000       0.000000      0.0000000 #> TNFRSF17              0        0.00000       0.000000      0.0000000 #> ICAM3                 0        2.52211       0.000000      0.9051745 #> FAP                   0        0.00000       0.000000      0.0000000 #> GZMB                  0        0.00000       2.242739      1.1213694 #> TSC2                  0        0.00000       0.000000      0.0000000 #>          X67_Y-65..CD8T X67_Y-66..CD8T X73_Y-67..CD8T X71_Y-64..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          4.416562       1.641226       4.606438       0.000000 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           0.000000       0.000000       2.293403       1.495159 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X49_Y-97..CD8T X54_Y-97..CD8T X48_Y-98..CD8T X50_Y-98..CD8T #> PDK4           0.000000       0.000000       0.000000       0.000000 #> TNFRSF17       0.000000       0.000000       0.000000       0.000000 #> ICAM3          0.000000       4.036189       0.000000       3.458783 #> FAP            0.000000       0.000000       0.000000       0.000000 #> GZMB           2.153787       1.822900       5.089387       0.845326 #> TSC2           0.000000       0.000000       0.000000       0.000000 #>          X48_Y-99..CD8T X50_Y-99..CD8T X51_Y-99..CD8T X49_Y-99..CD8T #> PDK4            0.00000       0.000000      0.0000000       0.000000 #> TNFRSF17        0.00000       0.000000      0.0000000       0.000000 #> ICAM3           3.35045       2.334399      2.9710057       3.458041 #> FAP             0.00000       0.000000      0.0000000       0.000000 #> GZMB            2.18397       2.279784      0.8159799       0.999553 #> TSC2            0.00000       0.568193      0.0000000       0.000000 #>          X53_Y-99..CD8T X50_Y-100..CD8T X52_Y-99..CD8T X51_Y-100..CD8T #> PDK4           0.000000       0.0000000       0.000000        0.000000 #> TNFRSF17       0.000000       0.0000000       0.000000        0.000000 #> ICAM3          3.231300       2.3632561       2.514855        3.125649 #> FAP            0.000000       0.0000000       0.000000        0.000000 #> GZMB           1.754761       3.3582018       2.418666        2.592712 #> TSC2           0.000000       0.2622429       0.000000        0.000000 #>          X49_Y-100..CD8T X53_Y-100..CD8T X48_Y-100..CD8T X51_Y-101..CD8T #> PDK4           0.0000000        0.000000       0.0000000        0.000000 #> TNFRSF17       0.0000000        0.000000       0.0000000        0.000000 #> ICAM3          3.4534618        1.565903       3.4045804        3.318310 #> FAP            0.0000000        0.000000       0.0000000        0.000000 #> GZMB           2.2096792        0.000000       0.0000000        3.487846 #> TSC2           0.7641125        0.000000       0.3539444        0.000000 #>          X49_Y-101..CD8T X48_Y-101..CD8T X50_Y-101..CD8T X54_Y-101..CD8T #> PDK4           0.0000000       0.0000000        0.000000        0.000000 #> TNFRSF17       0.0000000       0.0000000        0.000000        0.000000 #> ICAM3          1.4462725       2.3958996        1.295388        1.565903 #> FAP            0.0000000       0.0000000        0.000000        0.000000 #> GZMB           1.2231037       0.6176543        3.514943        1.878655 #> TSC2           0.3310743       0.0000000        0.000000        0.000000 #>          X52_Y-101..CD8T X49_Y-102..CD8T X50_Y-102..CD8T X53_Y-102..CD8T #> PDK4            0.000000       0.0000000        0.000000        0.000000 #> TNFRSF17        0.000000       0.0000000        0.000000        0.000000 #> ICAM3           3.426183       1.9967346        1.749537        2.437103 #> FAP             0.000000       0.0000000        0.000000        0.000000 #> GZMB            2.198423       1.4517498        1.984117        2.255925 #> TSC2            1.008806       0.3912697        0.000000        0.000000 #>          X52_Y-102..CD8T X52_Y-103..CD8T X50_Y-104..CD8T X49_Y-98..CD8T #> PDK4            0.000000        0.000000         0.00000        0.00000 #> TNFRSF17        0.000000        0.000000         0.00000        0.00000 #> ICAM3           2.412590        2.388077         2.11287        2.30756 #> FAP             0.000000        0.000000         0.00000        0.00000 #> GZMB            2.480004        2.704084         3.32776        2.30756 #> TSC2            0.000000        0.000000         0.00000        0.00000 #>          X53_Y-101..CD8T X48_Y-102..CD8T X48_Y-103..CD8T X46_Y-98..CD8T #> PDK4            0.000000       0.0000000        0.000000        0.00000 #> TNFRSF17        0.000000       0.0000000        0.000000        0.00000 #> ICAM3           2.348855       1.3239700        3.394891        1.74903 #> FAP             0.000000       0.0000000        0.000000        0.00000 #> GZMB            0.000000       2.0938069        0.000000        4.04196 #> TSC2            0.000000       0.4303966        0.000000        0.00000 #>          X47_Y-98..CD8T X43_Y-98..CD8T X42_Y-98..CD8T X46_Y-99..CD8T #> PDK4           0.000000              0              0              0 #> TNFRSF17       0.000000              0              0              0 #> ICAM3          5.880932              0              0              0 #> FAP            0.000000              0              0              0 #> GZMB           0.000000              0              0              0 #> TSC2           0.000000              0              0              0 #>          X44_Y-99..CD8T X43_Y-100..CD8T X45_Y-100..CD8T X43_Y-101..CD8T #> PDK4           0.000000        0.000000               0        0.000000 #> TNFRSF17       0.000000        0.000000               0        0.000000 #> ICAM3          0.000000        2.661704               0        0.000000 #> FAP            0.000000        0.000000               0        0.000000 #> GZMB           3.761591        2.327773               0        4.655546 #> TSC2           0.000000        0.000000               0        0.000000 #>          X47_Y-101..CD8T X42_Y-101..CD8T X43_Y-103..CD8T X45_Y-98..CD8T #> PDK4           0.0000000        0.000000               0       0.000000 #> TNFRSF17       0.0000000        0.000000               0       0.000000 #> ICAM3          1.5852851        0.000000               0       0.000000 #> FAP            0.0000000        0.000000               0       0.000000 #> GZMB           0.6964222        2.552774               0       2.292929 #> TSC2           0.0000000        0.000000               0       0.000000 #>          X47_Y-100..CD8T X46_Y-101..CD8T X47_Y-103..CD8T X27_Y-91..DC #> PDK4           0.0000000          0.0000        0.000000     4.615121 #> TNFRSF17       0.0000000          0.0000        0.000000     0.000000 #> ICAM3          2.2683142          2.9586        2.255925     3.931826 #> FAP            0.0000000          0.0000        0.000000     0.000000 #> GZMB           0.8091768          3.1339        0.000000     0.000000 #> TSC2           0.0000000          0.0000        0.000000     3.931826 #>          X24_Y-92..DC X27_Y-95..DC X24_Y-96..DC X26_Y-96..DC X26_Y-97..DC #> PDK4                0     4.088511     2.967728     2.681653     2.436754 #> TNFRSF17            0     0.000000     0.000000     0.000000     0.000000 #> ICAM3               0     0.000000     1.398362     2.454162     2.300260 #> FAP                 0     0.000000     0.000000     0.000000     0.000000 #> GZMB                0     0.000000     0.000000     0.000000     0.000000 #> TSC2                0     0.000000     0.000000     0.000000     0.000000 #>          X25_Y-97..DC X26_Y-98..DC X28_Y-96..DC X65_Y-92..DC X64_Y-93..DC #> PDK4         3.516896     2.416839      4.69771     3.406335     4.887178 #> TNFRSF17     0.000000     0.000000      0.00000     0.000000     0.000000 #> ICAM3        4.195087     2.772998      0.00000     0.000000     0.000000 #> FAP          0.000000     0.000000      0.00000     0.000000     0.000000 #> GZMB         0.000000     0.000000      0.00000     0.000000     0.000000 #> TSC2         0.000000     0.000000      0.00000     0.000000     0.000000 #>          X64_Y-94..DC X62_Y-94..DC X61_Y-95..DC X61_Y-96..DC X55_Y-91..DC #> PDK4         2.443589            0            0     0.000000     0.000000 #> TNFRSF17     0.000000            0            0     0.000000     0.000000 #> ICAM3        2.238421            0            0     3.155804     0.000000 #> FAP          0.000000            0            0     0.000000     0.000000 #> GZMB         0.000000            0            0     0.000000     0.000000 #> TSC2         0.000000            0            0     0.000000     1.637539 #>          X57_Y-92..DC X58_Y-92..DC X59_Y-92..DC X55_Y-92..DC X57_Y-94..DC #> PDK4                0     1.858741     1.858741            0     0.000000 #> TNFRSF17            0     0.000000     0.000000            0     0.000000 #> ICAM3               0     2.199204     2.199204            0     4.141856 #> FAP                 0     0.000000     0.000000            0     0.000000 #> GZMB                0     0.000000     0.000000            0     0.000000 #> TSC2                0     0.000000     0.000000            0     0.000000 #>          X55_Y-94..DC X56_Y-95..DC X57_Y-96..DC X58_Y-96..DC X57_Y-97..DC #> PDK4         2.105524            0     4.095820     1.694787     2.047910 #> TNFRSF17     0.000000            0     0.000000     0.000000     0.000000 #> ICAM3        1.167787            0     1.837663     1.694787     1.782712 #> FAP          0.000000            0     0.000000     0.000000     0.000000 #> GZMB         0.000000            0     0.000000     0.000000     0.000000 #> TSC2         0.000000            0     0.000000     1.694787     0.000000 #>          X59_Y-96..DC X56_Y-96..DC X76_Y-100..DC X73_Y-100..DC X74_Y-101..DC #> PDK4                0            0      0.000000      0.000000       4.38658 #> TNFRSF17            0            0      0.000000      0.000000       0.00000 #> ICAM3               0            0      0.000000      4.214594       0.00000 #> FAP                 0            0      0.000000      0.000000       0.00000 #> GZMB                0            0      3.811077      0.000000       0.00000 #> TSC2                0            0      0.000000      0.000000       0.00000 #>          X77_Y-102..DC X78_Y-85..DC X74_Y-86..DC X75_Y-86..DC X74_Y-87..DC #> PDK4                 0     1.923706     0.000000     0.000000            0 #> TNFRSF17             0     0.000000     0.000000     0.000000            0 #> ICAM3                0     2.264917     5.333615     2.201191            0 #> FAP                  0     0.000000     0.000000     0.000000            0 #> GZMB                 0     0.000000     0.000000     0.000000            0 #> TSC2                 0     0.000000     0.000000     0.000000            0 #>          X75_Y-88..DC X73_Y-90..DC X72_Y-87..DC X32_Y-74..DC X42_Y-66..DC #> PDK4         0.000000    0.9188316     2.288148     2.213289     2.057408 #> TNFRSF17     0.000000    0.0000000     0.000000     0.000000     0.000000 #> ICAM3        4.163422    2.0801523     0.000000     2.209223     2.060380 #> FAP          0.000000    0.0000000     0.000000     0.000000     0.000000 #> GZMB         0.000000    0.0000000     0.000000     0.000000     0.000000 #> TSC2         0.000000    0.0000000     0.000000     0.000000     0.000000 #>          X41_Y-69..DC X39_Y-70..DC X39_Y-74..DC X40_Y-75..DC X39_Y-75..DC #> PDK4         1.143054     3.186429     4.010973     4.129745     3.679083 #> TNFRSF17     0.000000     0.000000     0.000000     0.000000     0.000000 #> ICAM3        2.923962     0.000000     0.000000     3.452557     3.679083 #> FAP          0.000000     0.000000     0.000000     0.000000     0.000000 #> GZMB         0.000000     0.000000     0.000000     0.000000     0.000000 #> TSC2         0.000000     0.000000     0.000000     0.000000     0.000000 #>          X37_Y-76..DC X40_Y-76..DC X37_Y-77..DC X73_Y-75..DC X60_Y-70..DC #> PDK4         0.000000     0.000000     1.750587            0     0.000000 #> TNFRSF17     0.000000     0.000000     0.000000            0     0.000000 #> ICAM3        3.101507     3.888691     1.901769            0     4.333204 #> FAP          0.000000     0.000000     0.000000            0     0.000000 #> GZMB         0.000000     0.000000     0.000000            0     0.000000 #> TSC2         0.000000     0.000000     0.000000            0     0.000000 #>          X73_Y-76..DC X72_Y-75..DC X54_Y-78..DC X69_Y-69..DC X72_Y-69..DC #> PDK4         0.000000            0     0.000000     0.000000     4.303966 #> TNFRSF17     0.000000            0     0.000000     0.000000     0.000000 #> ICAM3        5.235994            0     2.148396     4.532863     0.000000 #> FAP          0.000000            0     0.000000     0.000000     0.000000 #> GZMB         0.000000            0     0.000000     0.000000     0.000000 #> TSC2         0.000000            0     0.000000     0.000000     0.000000 #>          X48_Y-79..DC X54_Y-79..DC X52_Y-73..DC X53_Y-74..DC X54_Y-77..DC #> PDK4         1.402683     0.000000     0.000000            0            0 #> TNFRSF17     0.000000     0.000000     0.000000            0            0 #> ICAM3        1.416001     2.148396     4.585859            0            0 #> FAP          0.000000     0.000000     0.000000            0            0 #> GZMB         0.000000     0.000000     0.000000            0            0 #> TSC2         0.000000     0.000000     0.000000            0            0 #>          X46_Y-91..DC X43_Y-92..DC X42_Y-92..DC X44_Y-92..DC X45_Y-92..DC #> PDK4                0    0.0000000    0.0000000     0.000000     0.000000 #> TNFRSF17            0    0.0000000    0.0000000     0.000000     0.000000 #> ICAM3               0    0.8653708    0.8947885     3.461483     2.288148 #> FAP                 0    0.0000000    0.0000000     0.000000     0.000000 #> GZMB                0    0.0000000    0.0000000     0.000000     0.000000 #> TSC2                0    0.0000000    0.0000000     0.000000     0.000000 #>          X42_Y-93..DC X43_Y-93..DC X44_Y-93..DC X44_Y-94..DC X42_Y-94..DC #> PDK4                0            0     0.000000     0.000000            0 #> TNFRSF17            0            0     0.000000     0.000000            0 #> ICAM3               0            0     2.262653     2.393944            0 #> FAP                 0            0     0.000000     0.000000            0 #> GZMB                0            0     0.000000     0.000000            0 #> TSC2                0            0     0.000000     0.000000            0 #>          X46_Y-95..DC X43_Y-95..DC X44_Y-95..DC X45_Y-95..DC X42_Y-95..DC #> PDK4         0.000000     0.000000     0.000000       0.0000     0.000000 #> TNFRSF17     0.000000     0.000000     0.000000       0.0000     0.000000 #> ICAM3        1.281723     1.112847     1.483796       0.0000     1.708544 #> FAP          0.000000     0.000000     0.000000       0.0000     0.000000 #> GZMB         0.000000     0.000000     1.215267       1.8229     0.000000 #> TSC2         0.000000     0.000000     0.000000       0.0000     0.000000 #>          X42_Y-96..DC X44_Y-96..DC X47_Y-97..DC X46_Y-92..DC X45_Y-93..DC #> PDK4          0.00000            0       4.0972            0     0.000000 #> TNFRSF17      0.00000            0       0.0000            0     0.000000 #> ICAM3         1.53776            0       0.0000            0     2.262653 #> FAP           0.00000            0       0.0000            0     0.000000 #> GZMB          0.00000            0       0.0000            0     0.000000 #> TSC2          0.00000            0       0.0000            0     0.000000 #>          X46_Y-96..DC X25_Y-74..DC X26_Y-78..DC X35_Y-70..DC X30_Y-80..DC #> PDK4         4.348158     0.000000     3.038826            0     3.664146 #> TNFRSF17     0.000000     0.000000     0.000000            0     0.000000 #> ICAM3        0.000000     4.234501     3.038826            0     0.000000 #> FAP          0.000000     0.000000     0.000000            0     0.000000 #> GZMB         0.000000     0.000000     0.000000            0     0.000000 #> TSC2         0.000000     0.000000     0.000000            0     0.000000 #>          X24_Y-66..DC X24_Y-67..DC X28_Y-72..DC X25_Y-72..DC X22_Y-83..DC #> PDK4         1.236559     1.236559     2.155597            0            0 #> TNFRSF17     0.000000     0.000000     0.000000            0            0 #> ICAM3        2.797121     2.797121     2.155597            0            0 #> FAP          0.000000     0.000000     0.000000            0            0 #> GZMB         0.000000     0.000000     0.000000            0            0 #> TSC2         0.000000     0.000000     0.000000            0            0 #>          X23_Y-80..DC X22_Y-85..DC X46_Y-64..DC X46_Y-65..DC X47_Y-65..DC #> PDK4                0       2.0231     1.308167     1.308167            0 #> TNFRSF17            0       0.0000     0.000000     0.000000            0 #> ICAM3               0       0.0000     2.555106     2.555106            0 #> FAP                 0       0.0000     0.000000     0.000000            0 #> GZMB                0       0.0000     0.000000     0.000000            0 #> TSC2                0       0.0000     0.000000     0.000000            0 #>          X44_Y-65..DC X47_Y-66..DC X45_Y-66..DC X46_Y-67..DC X51_Y-65..DC #> PDK4         0.000000       0.0000     0.000000     2.084836            0 #> TNFRSF17     0.000000       0.0000     0.000000     0.000000            0 #> ICAM3        3.197619       2.0371     1.852899     0.000000            0 #> FAP          0.000000       0.0000     0.000000     0.000000            0 #> GZMB         0.000000       0.0000     0.000000     0.000000            0 #> TSC2         0.000000       0.0000     0.000000     0.000000            0 #>          X52_Y-66..DC X51_Y-67..DC X53_Y-65..DC X51_Y-66..DC X49_Y-66..DC #> PDK4                0     1.732239            0            0     1.733741 #> TNFRSF17            0     0.000000            0            0     0.000000 #> ICAM3               0     1.799849            0            0     1.733741 #> FAP                 0     0.000000            0            0     0.000000 #> GZMB                0     0.000000            0            0     0.000000 #> TSC2                0     0.000000            0            0     0.000000 #>          X36_Y-79..DC X37_Y-80..DC X37_Y-82..DC X42_Y-83..DC X36_Y-83..DC #> PDK4         2.463577     4.635125     2.900527            0     0.000000 #> TNFRSF17     0.000000     0.000000     0.000000            0     0.000000 #> ICAM3        0.000000     4.635125     0.000000            0     1.377586 #> FAP          0.000000     0.000000     0.000000            0     0.000000 #> GZMB         0.000000     0.000000     0.000000            0     0.000000 #> TSC2         0.000000     0.000000     0.000000            0     0.000000 #>          X36_Y-84..DC X39_Y-84..DC X44_Y-73..DC X45_Y-73..DC X44_Y-74..DC #> PDK4         0.000000            0     1.830224     0.000000     1.830224 #> TNFRSF17     0.000000            0     0.000000     0.000000     0.000000 #> ICAM3        1.377586            0     1.860705     3.819994     0.000000 #> FAP          0.000000            0     0.000000     0.000000     0.000000 #> GZMB         0.000000            0     0.000000     0.000000     0.000000 #> TSC2         0.000000            0     0.000000     0.000000     0.000000 #>          X45_Y-74..DC X43_Y-74..DC X44_Y-75..DC X46_Y-75..DC X44_Y-76..DC #> PDK4         0.000000            0            0      0.00000     0.000000 #> TNFRSF17     0.000000            0            0      0.00000     0.000000 #> ICAM3        4.138814            0            0      1.28397     4.595516 #> FAP          0.000000            0            0      0.00000     0.000000 #> GZMB         0.000000            0            0      0.00000     0.000000 #> TSC2         0.000000            0            0      0.00000     0.000000 #>          X47_Y-77..DC X46_Y-77..DC X47_Y-78..DC X47_Y-75..DC X45_Y-77..DC #> PDK4         2.157414     1.438276     0.000000            0     0.000000 #> TNFRSF17     0.000000     0.000000     0.000000            0     0.000000 #> ICAM3        1.817480     2.889927     3.926936            0     5.034819 #> FAP          0.000000     0.000000     0.000000            0     0.000000 #> GZMB         0.000000     0.000000     0.000000            0     0.000000 #> TSC2         0.000000     0.000000     0.000000            0     0.000000 #>          X43_Y-78..DC X76_Y-82..DC X77_Y-85..DC X76_Y-85..DC X75_Y-80..DC #> PDK4         3.782335      0.00000     0.000000     0.000000            0 #> TNFRSF17     0.000000      0.00000     0.000000     0.000000            0 #> ICAM3        0.000000      4.70854     4.067964     4.067964            0 #> FAP          0.000000      0.00000     0.000000     0.000000            0 #> GZMB         0.000000      0.00000     0.000000     0.000000            0 #> TSC2         3.782335      0.00000     0.000000     0.000000            0 #>          X75_Y-69..DC X75_Y-70..DC X77_Y-71..DC X73_Y-71..DC X73_Y-70..DC #> PDK4         4.402383     2.201191            0     0.000000            0 #> TNFRSF17     0.000000     0.000000            0     0.000000            0 #> ICAM3        3.721409     1.860705            0     2.536743            0 #> FAP          0.000000     0.000000            0     0.000000            0 #> GZMB         0.000000     0.000000            0     0.000000            0 #> TSC2         0.000000     0.000000            0     0.000000            0 #>          X60_Y-68..DC X59_Y-68..DC X58_Y-69..DC X58_Y-66..DC X47_Y-79..DC #> PDK4         1.541691     0.000000     4.333204            0     2.104024 #> TNFRSF17     0.000000     0.000000     0.000000            0     0.000000 #> ICAM3        2.814321     4.221481     0.000000            0     0.000000 #> FAP          0.000000     0.000000     0.000000            0     0.000000 #> GZMB         0.000000     0.000000     0.000000            0     0.000000 #> TSC2         0.000000     0.000000     0.000000            0     0.000000 #>          X44_Y-80..DC X43_Y-80..DC X46_Y-80..DC X44_Y-82..DC X43_Y-83..DC #> PDK4         0.000000            0     0.000000     0.000000    0.7938436 #> TNFRSF17     0.000000            0     0.000000     0.000000    0.0000000 #> ICAM3        1.919237            0     3.922071     1.768058    0.0000000 #> FAP          0.000000            0     0.000000     0.000000    0.0000000 #> GZMB         0.000000            0     0.000000     0.000000    0.0000000 #> TSC2         0.000000            0     0.000000     0.000000    0.0000000 #>          X43_Y-84..DC X42_Y-84..DC X43_Y-85..DC X49_Y-91..DC X51_Y-93..DC #> PDK4         1.686553     3.596243     2.012185     0.000000            0 #> TNFRSF17     0.000000     0.000000     0.000000     0.000000            0 #> ICAM3        0.000000     3.596243     0.000000     3.971863            0 #> FAP          0.000000     0.000000     0.000000     0.000000            0 #> GZMB         0.000000     0.000000     0.000000     0.000000            0 #> TSC2         0.000000     0.000000     0.000000     0.000000            0 #>          X72_Y-82..DC X73_Y-83..DC X70_Y-84..DC X71_Y-85..DC X71_Y-79..DC #> PDK4                0            0            0     4.163422            0 #> TNFRSF17            0            0            0     0.000000            0 #> ICAM3               0            0            0     4.163422            0 #> FAP                 0            0            0     0.000000            0 #> GZMB                0            0            0     0.000000            0 #> TSC2                0            0            0     0.000000            0 #>          X49_Y-67..DC X48_Y-67..DC X48_Y-68..DC X50_Y-69..DC X51_Y-70..DC #> PDK4         1.155827     0.000000     0.000000     1.577902            0 #> TNFRSF17     0.000000     0.000000     0.000000     0.000000            0 #> ICAM3        3.443030     3.430805     1.812122     4.041122            0 #> FAP          0.000000     0.000000     0.000000     0.000000            0 #> GZMB         0.000000     0.000000     0.000000     0.000000            0 #> TSC2         0.000000     0.000000     0.000000     0.000000            0 #>          X50_Y-68..DC X49_Y-69..DC X56_Y-81..DC X59_Y-82..DC X59_Y-84..DC #> PDK4                0     3.155804     0.000000            0            0 #> TNFRSF17            0     0.000000     0.000000            0            0 #> ICAM3               0     3.827419     4.348158            0            0 #> FAP                 0     0.000000     0.000000            0            0 #> GZMB                0     0.000000     0.000000            0            0 #> TSC2                0     0.000000     0.000000            0            0 #>          X60_Y-85..DC X55_Y-80..DC X56_Y-82..DC X62_Y-84..DC X35_Y-91..DC #> PDK4                0            0            0            0     0.000000 #> TNFRSF17            0            0            0            0     0.000000 #> ICAM3               0            0            0            0     4.111455 #> FAP                 0            0            0            0     0.000000 #> GZMB                0            0            0            0     0.000000 #> TSC2                0            0            0            0     0.000000 #>          X35_Y-93..DC X34_Y-93..DC X35_Y-94..DC X34_Y-94..DC X36_Y-94..DC #> PDK4        1.6697617     2.226349            0            0     0.000000 #> TNFRSF17    0.0000000     0.000000            0            0     0.000000 #> ICAM3       0.9866613     1.315548            0            0     3.726738 #> FAP         0.0000000     0.000000            0            0     0.000000 #> GZMB        0.0000000     0.000000            0            0     2.378450 #> TSC2        0.0000000     0.000000            0            0     0.000000 #>          X34_Y-96..DC X35_Y-97..DC X42_Y-85..DC X42_Y-86..DC X45_Y-87..DC #> PDK4         3.893389     0.000000     2.822118     0.000000            0 #> TNFRSF17     0.000000     0.000000     0.000000     0.000000            0 #> ICAM3        3.220413     3.860974     3.010429     3.841744            0 #> FAP          0.000000     0.000000     0.000000     0.000000            0 #> GZMB         0.000000     0.000000     0.000000     0.000000            0 #> TSC2         0.000000     0.000000     0.000000     0.000000            0 #>          X44_Y-88..DC X45_Y-89..DC X45_Y-90..DC X44_Y-90..DC X42_Y-91..DC #> PDK4         3.847411     2.127412     4.254824      0.00000     0.000000 #> TNFRSF17     0.000000     0.000000     0.000000      0.00000     0.000000 #> ICAM3        3.847411     1.673146     0.000000      2.03995     2.620585 #> FAP          0.000000     0.000000     0.000000      0.00000     0.000000 #> GZMB         0.000000     0.000000     0.000000      0.00000     0.000000 #> TSC2         0.000000     0.000000     0.000000      0.00000     0.000000 #>          X46_Y-89..DC X47_Y-89..DC X47_Y-90..DC X53_Y-80..DC X52_Y-80..DC #> PDK4         4.494189            0            0     0.000000     0.000000 #> TNFRSF17     0.000000            0            0     0.000000     0.000000 #> ICAM3        0.000000            0            0     4.459799     2.229899 #> FAP          0.000000            0            0     0.000000     0.000000 #> GZMB         0.000000            0            0     0.000000     0.000000 #> TSC2         0.000000            0            0     0.000000     0.000000 #>          X51_Y-81..DC X52_Y-79..DC X52_Y-84..DC X70_Y-92..DC X72_Y-92..DC #> PDK4                0       0.0000            0     0.000000     3.559047 #> TNFRSF17            0       0.0000            0     0.000000     0.000000 #> ICAM3               0       1.4866            0     4.473981     4.237859 #> FAP                 0       0.0000            0     0.000000     0.000000 #> GZMB                0       0.0000            0     0.000000     0.000000 #> TSC2                0       0.0000            0     0.000000     0.000000 #>          X69_Y-92..DC X70_Y-95..DC X68_Y-97..DC X76_Y-92..DC X75_Y-92..DC #> PDK4                0            0     0.000000     0.000000     4.589067 #> TNFRSF17            0            0     0.000000     0.000000     0.000000 #> ICAM3               0            0     2.031452     2.521216     3.510576 #> FAP                 0            0     0.000000     0.000000     0.000000 #> GZMB                0            0     0.000000     0.000000     0.000000 #> TSC2                0            0     0.000000     0.000000     0.000000 #>          X74_Y-96..DC X73_Y-93..DC X74_Y-93..DC X74_Y-97..DC X42_Y-67..DC #> PDK4         4.418446     0.000000     0.000000            0     4.114816 #> TNFRSF17     0.000000     0.000000     0.000000            0     0.000000 #> ICAM3        4.418446     0.000000     0.000000            0     0.000000 #> FAP          0.000000     0.000000     0.000000            0     0.000000 #> GZMB         0.000000     0.000000     0.000000            0     0.000000 #> TSC2         0.000000     1.828383     1.828383            0     0.000000 #>          X46_Y-68..DC X47_Y-69..DC X45_Y-70..DC X47_Y-71..DC X46_Y-71..DC #> PDK4         0.000000            0     3.615404     0.000000     2.221523 #> TNFRSF17     0.000000            0     0.000000     0.000000     0.000000 #> ICAM3        0.000000            0     4.011860     2.855714     0.000000 #> FAP          0.000000            0     0.000000     0.000000     0.000000 #> GZMB         2.166602            0     0.000000     0.000000     0.000000 #> TSC2         0.000000            0     0.000000     0.000000     0.000000 #>          X45_Y-72..DC X43_Y-68..DC X48_Y-70..DC X28_Y-88..DC X26_Y-91..DC #> PDK4                0            0     0.000000     4.195087            0 #> TNFRSF17            0            0     0.000000     0.000000            0 #> ICAM3               0            0     3.307465     0.000000            0 #> FAP                 0            0     0.000000     0.000000            0 #> GZMB                0            0     0.000000     0.000000            0 #> TSC2                0            0     0.000000     0.000000            0 #>          X33_Y-86..DC X34_Y-90..DC X33_Y-89..DC X37_Y-89..DC X39_Y-91..DC #> PDK4         3.122011     1.600965     0.000000     2.908595     3.069454 #> TNFRSF17     0.000000     0.000000     0.000000     0.000000     0.000000 #> ICAM3        3.122011     2.304688     5.199492     4.253114     2.231309 #> FAP          0.000000     0.000000     0.000000     0.000000     0.000000 #> GZMB         0.000000     0.000000     0.000000     0.000000     0.000000 #> TSC2         0.000000     0.000000     0.000000     0.000000     1.363459 #>          X36_Y-91..DC X36_Y-87..DC X36_Y-88..DC X38_Y-90..DC X34_Y-100..DC #> PDK4         0.000000            0            0            0      0.000000 #> TNFRSF17     0.000000            0            0            0      0.000000 #> ICAM3        4.045108            0            0            0      3.660449 #> FAP          0.000000            0            0            0      0.000000 #> GZMB         0.000000            0            0            0      0.000000 #> TSC2         0.000000            0            0            0      0.000000 #>          X31_Y-101..DC X30_Y-102..DC X33_Y-103..DC X34_Y-103..DC X30_Y-103..DC #> PDK4          0.000000      3.755482      0.000000             0      3.661595 #> TNFRSF17      0.000000      0.000000      0.000000             0      0.000000 #> ICAM3         3.253301      3.755482      2.411215             0      4.198737 #> FAP           0.000000      0.000000      0.000000             0      0.000000 #> GZMB          0.000000      0.000000      0.000000             0      0.000000 #> TSC2          0.000000      0.000000      0.000000             0      0.000000 #>          X32_Y-103..DC X22_Y-86..DC X22_Y-87..DC X23_Y-99..DC X27_Y-98..DC #> PDK4         0.6393755     0.000000            0     4.074201     1.555851 #> TNFRSF17     0.0000000     0.000000            0     0.000000     0.000000 #> ICAM3        2.0093461     4.760721            0     4.074201     2.090090 #> FAP          0.0000000     0.000000            0     0.000000     0.000000 #> GZMB         0.0000000     0.000000            0     0.000000     0.000000 #> TSC2         0.0000000     0.000000            0     0.000000     0.000000 #>          X27_Y-101..DC X28_Y-101..DC X30_Y-101..DC X28_Y-102..DC X28_Y-103..DC #> PDK4                 0      3.494957      1.755288      0.000000     0.7242994 #> TNFRSF17             0      0.000000      0.000000      0.000000     0.0000000 #> ICAM3                0      4.858226      3.381939      3.926936     1.9713169 #> FAP                  0      0.000000      0.000000      0.000000     0.0000000 #> GZMB                 0      0.000000      0.000000      0.000000     0.7242994 #> TSC2                 0      0.000000      0.000000      0.000000     0.7242994 #>          X28_Y-104..DC X74_Y-104..DC X73_Y-107..DC X74_Y-105..DC X61_Y-100..DC #> PDK4          0.000000      0.000000      0.000000             0      1.644943 #> TNFRSF17      0.000000      0.000000      0.000000             0      0.000000 #> ICAM3         1.597936      1.562044      0.000000             0      4.150043 #> FAP           0.000000      0.000000      0.000000             0      0.000000 #> GZMB          0.000000      0.000000      2.242739             0      0.000000 #> TSC2          0.000000      0.000000      0.000000             0      0.000000 #>          X63_Y-100..DC X64_Y-101..DC X63_Y-101..DC X61_Y-102..DC X62_Y-104..DC #> PDK4          4.508691      4.146185      1.512984      0.000000             0 #> TNFRSF17      0.000000      0.000000      0.000000      0.000000             0 #> ICAM3         2.120614      4.486864      1.512984      4.405041             0 #> FAP           0.000000      0.000000      0.000000      0.000000             0 #> GZMB          0.000000      2.269476      1.512984      0.000000             0 #> TSC2          0.000000      0.000000      0.000000      0.000000             0 #>          X61_Y-101..DC X62_Y-101..DC X22_Y-105..DC X22_Y-107..DC X72_Y-86..DC #> PDK4           0.00000             0             0      0.000000     0.000000 #> TNFRSF17       0.00000             0             0      0.000000     0.000000 #> ICAM3          3.93674             0             0      2.509883     3.879363 #> FAP            0.00000             0             0      0.000000     0.000000 #> GZMB           0.00000             0             0      0.000000     0.000000 #> TSC2           0.00000             0             0      0.000000     3.879363 #>          X70_Y-86..DC X68_Y-87..DC X68_Y-88..DC X70_Y-89..DC X72_Y-90..DC #> PDK4                0            0     2.234142     4.363345     1.837663 #> TNFRSF17            0            0     0.000000     0.000000     0.000000 #> ICAM3               0            0     4.318978     0.000000     1.837663 #> FAP                 0            0     0.000000     0.000000     0.000000 #> GZMB                0            0     0.000000     0.000000     0.000000 #> TSC2                0            0     0.000000     0.000000     0.000000 #>          X72_Y-89..DC X25_Y-104..DC X24_Y-105..DC X27_Y-105..DC X25_Y-105..DC #> PDK4                0      4.430669      0.000000        0.0000      0.000000 #> TNFRSF17            0      0.000000      0.000000        0.0000      0.000000 #> ICAM3               0      0.000000      3.494957        1.7248      2.608787 #> FAP                 0      0.000000      0.000000        0.0000      0.000000 #> GZMB                0      0.000000      0.000000        0.0000      0.000000 #> TSC2                0      0.000000      0.000000        0.0000      0.000000 #>          X27_Y-106..DC X25_Y-106..DC X28_Y-106..DC X26_Y-106..DC X25_Y-107..DC #> PDK4            0.0000      2.816016      2.517409      1.839541     0.7358165 #> TNFRSF17        0.0000      0.000000      0.000000      0.000000     0.0000000 #> ICAM3           1.7248      1.216480      2.174079      1.839541     0.7358165 #> FAP             0.0000      0.000000      0.000000      0.000000     0.0000000 #> GZMB            0.0000      0.000000      0.000000      1.901769     0.7607077 #> TSC2            0.0000      0.000000      0.000000      0.000000     0.0000000 #>          X26_Y-107..DC X69_Y-99..DC X67_Y-102..DC X72_Y-102..DC X69_Y-102..DC #> PDK4         0.9197706            0             0      0.000000      2.137791 #> TNFRSF17     0.0000000            0             0      0.000000      0.000000 #> ICAM3        0.9197706            0             0      4.665919      4.808650 #> FAP          0.0000000            0             0      0.000000      0.000000 #> GZMB         0.9508847            0             0      0.000000      0.000000 #> TSC2         0.0000000            0             0      0.000000      0.000000 #>          X73_Y-103..DC X71_Y-101..DC X70_Y-105..DC X72_Y-105..DC X68_Y-105..DC #> PDK4                 0             0             0             0      4.241228 #> TNFRSF17             0             0             0             0      0.000000 #> ICAM3                0             0             0             0      4.241228 #> FAP                  0             0             0             0      0.000000 #> GZMB                 0             0             0             0      0.000000 #> TSC2                 0             0             0             0      0.000000 #>          X71_Y-106..DC X72_Y-106..DC X65_Y-107..DC X64_Y-106..DC X53_Y-104..DC #> PDK4           0.00000      0.000000             0             0      0.000000 #> TNFRSF17       0.00000      0.000000             0             0      0.000000 #> ICAM3          4.18867      4.494189             0             0      4.374893 #> FAP            0.00000      0.000000             0             0      0.000000 #> GZMB           0.00000      0.000000             0             0      0.000000 #> TSC2           0.00000      0.000000             0             0      0.000000 #>          X49_Y-104..DC X54_Y-105..DC X49_Y-105..DC X48_Y-106..DC X53_Y-105..DC #> PDK4          4.018989      0.000000      2.009494      0.000000      2.034268 #> TNFRSF17      0.000000      0.000000      0.000000      0.000000      0.000000 #> ICAM3         0.000000      3.741288      2.185514      2.332959      4.563994 #> FAP           0.000000      0.000000      0.000000      0.000000      0.000000 #> GZMB          0.000000      0.000000      0.000000      0.000000      0.000000 #> TSC2          0.000000      0.000000      0.000000      0.000000      0.000000 #>          X33_Y-104..DC X32_Y-104..DC X34_Y-104..DC X30_Y-105..DC X30_Y-106..DC #> PDK4          0.000000      1.278751             0      4.013637      2.006819 #> TNFRSF17      0.000000      0.000000             0      0.000000      0.000000 #> ICAM3         3.858725      2.572483             0      4.013637      2.006819 #> FAP           0.000000      0.000000             0      0.000000      0.000000 #> GZMB          0.000000      0.000000             0      0.000000      0.000000 #> TSC2          0.000000      0.000000             0      0.000000      0.000000 #>          X30_Y-107..DC X29_Y-107..DC X35_Y-104..DC X34_Y-106..DC X34_Y-107..DC #> PDK4          0.000000      0.000000      4.451387      4.371029      2.185514 #> TNFRSF17      0.000000      0.000000      0.000000      0.000000      0.000000 #> ICAM3         4.511964      4.511964      0.000000      0.000000      2.060380 #> FAP           0.000000      0.000000      0.000000      0.000000      0.000000 #> GZMB          0.000000      0.000000      0.000000      0.000000      0.000000 #> TSC2          0.000000      0.000000      0.000000      0.000000      0.000000 #>          X58_Y-97..DC X59_Y-98..DC X55_Y-98..DC X56_Y-98..DC X56_Y-99..DC #> PDK4                0     0.000000      0.00000            0            0 #> TNFRSF17            0     0.000000      0.00000            0            0 #> ICAM3               0     3.874733      3.79926            0            0 #> FAP                 0     0.000000      0.00000            0            0 #> GZMB                0     0.000000      0.00000            0            0 #> TSC2                0     0.000000      0.00000            0            0 #>          X55_Y-100..DC X58_Y-100..DC X57_Y-100..DC X56_Y-101..DC X59_Y-103..DC #> PDK4           0.00000      1.749030      0.000000      0.000000      0.000000 #> TNFRSF17       0.00000      0.000000      0.000000      0.000000      0.000000 #> ICAM3          3.00427      4.632675      5.089387      3.239978      0.000000 #> FAP            0.00000      0.000000      0.000000      0.000000      0.000000 #> GZMB           0.00000      0.000000      0.000000      0.000000      4.157211 #> TSC2           0.00000      1.749030      0.000000      0.000000      0.000000 #>          X59_Y-99..DC X56_Y-100..DC X59_Y-102..DC X57_Y-103..DC X41_Y-98..DC #> PDK4                0             0      0.000000             0     0.000000 #> TNFRSF17            0             0      0.000000             0     0.000000 #> ICAM3               0             0      0.000000             0     2.127412 #> FAP                 0             0      0.000000             0     0.000000 #> GZMB                0             0      2.078606             0     0.000000 #> TSC2                0             0      0.000000             0     0.000000 #>          X39_Y-98..DC X40_Y-99..DC X38_Y-99..DC X42_Y-100..DC X38_Y-100..DC #> PDK4                0            0            0      0.000000       1.77331 #> TNFRSF17            0            0            0      0.000000       0.00000 #> ICAM3               0            0            0      4.008316       1.77331 #> FAP                 0            0            0      0.000000       0.00000 #> GZMB                0            0            0      0.000000       0.00000 #> TSC2                0            0            0      0.000000       0.00000 #>          X39_Y-100..DC X38_Y-101..DC X41_Y-102..DC X41_Y-103..DC X41_Y-104..DC #> PDK4            0.0000      1.042751      0.000000      0.000000     0.8425977 #> TNFRSF17        0.0000      0.000000      0.000000      0.000000     0.0000000 #> ICAM3           1.7248      0.000000      4.645283      4.742853     1.0115501 #> FAP             0.0000      0.000000      0.000000      0.000000     0.0000000 #> GZMB            0.0000      0.000000      0.000000      0.000000     0.0000000 #> TSC2            0.0000      0.000000      0.000000      0.000000     0.0000000 #>          X66_Y-87..DC X62_Y-88..DC X64_Y-90..DC X65_Y-90..DC X62_Y-91..DC #> PDK4                0     0.000000     0.000000     3.825224     0.000000 #> TNFRSF17            0     0.000000     0.000000     0.000000     0.000000 #> ICAM3               0     3.884015     1.325662     3.825224     2.335573 #> FAP                 0     0.000000     0.000000     0.000000     0.000000 #> GZMB                0     3.884015     0.000000     0.000000     0.000000 #> TSC2                0     0.000000     0.000000     0.000000     0.000000 #>          X66_Y-91..DC X66_Y-86..DC X62_Y-86..DC X63_Y-87..DC X41_Y-91..DC #> PDK4                0            0       4.0972            0            0 #> TNFRSF17            0            0       0.0000            0            0 #> ICAM3               0            0       0.0000            0            0 #> FAP                 0            0       0.0000            0            0 #> GZMB                0            0       0.0000            0            0 #> TSC2                0            0       0.0000            0            0 #>          X40_Y-91..DC X37_Y-92..DC X37_Y-93..DC X40_Y-93..DC X36_Y-93..DC #> PDK4         3.411989     0.000000     0.000000     0.000000     0.000000 #> TNFRSF17     0.000000     0.000000     0.000000     0.000000     0.000000 #> ICAM3        0.000000     3.367717     3.517465     3.029411     3.675326 #> FAP          0.000000     0.000000     0.000000     0.000000     0.000000 #> GZMB         0.000000     0.000000     2.378450     0.000000     4.756900 #> TSC2         0.000000     0.000000     0.000000     0.000000     0.000000 #>          X41_Y-94..DC X41_Y-95..DC X39_Y-95..DC X39_Y-96..DC X41_Y-96..DC #> PDK4                0     0.000000            0    0.9733472      0.00000 #> TNFRSF17            0     0.000000            0    0.0000000      0.00000 #> ICAM3               0     1.270718            0    0.9733472      1.53776 #> FAP                 0     0.000000            0    0.0000000      0.00000 #> GZMB                0     0.000000            0    0.0000000      0.00000 #> TSC2                0     0.000000            0    0.0000000      0.00000 #>          X40_Y-94..DC X36_Y-95..DC X39_Y-104..DC X40_Y-104..DC X41_Y-105..DC #> PDK4         0.000000            0      3.782335     0.6740781      1.123464 #> TNFRSF17     0.000000            0      0.000000     0.0000000      0.000000 #> ICAM3        3.926936            0      0.000000     1.6685985      2.780998 #> FAP          0.000000            0      0.000000     0.0000000      0.000000 #> GZMB         0.000000            0      0.000000     0.0000000      0.000000 #> TSC2         0.000000            0      0.000000     0.0000000      0.000000 #>          X40_Y-105..DC X39_Y-105..DC X37_Y-106..DC X40_Y-106..DC X37_Y-105..DC #> PDK4          0.000000             0             0             0      0.000000 #> TNFRSF17      0.000000             0             0             0      0.000000 #> ICAM3         4.296792             0             0             0      3.624244 #> FAP           0.000000             0             0             0      0.000000 #> GZMB          0.000000             0             0             0      0.000000 #> TSC2          0.000000             0             0             0      0.000000 #>          X41_Y-106..DC X40_Y-107..DC X52_Y-86..DC X52_Y-88..DC X50_Y-89..DC #> PDK4          0.000000      0.000000            0     0.000000            0 #> TNFRSF17      0.000000      0.000000            0     0.000000            0 #> ICAM3         0.000000      1.833929            0     1.958616            0 #> FAP           0.000000      0.000000            0     0.000000            0 #> GZMB          0.000000      0.000000            0     0.000000            0 #> TSC2          4.108909      0.000000            0     0.000000            0 #>          X53_Y-85..DC X51_Y-86..DC X52_Y-87..DC X51_Y-88..DC X49_Y-88..DC #> PDK4                0            0            0     0.000000            0 #> TNFRSF17            0            0            0     0.000000            0 #> ICAM3               0            0            0     4.108909            0 #> FAP                 0            0            0     0.000000            0 #> GZMB                0            0            0     0.000000            0 #> TSC2                0            0            0     0.000000            0 #>          X57_Y-90..DC X55_Y-90..DC X61_Y-85..DC X48_Y-98..DC X48_Y-99..DC #> PDK4                0     0.000000            0     0.000000     0.000000 #> TNFRSF17            0     0.000000            0     0.000000     0.000000 #> ICAM3               0     0.000000            0     3.232025     1.616013 #> FAP                 0     0.000000            0     0.000000     0.000000 #> GZMB                0     0.000000            0     0.000000     0.000000 #> TSC2                0     3.275078            0     0.000000     0.000000 #>          X53_Y-98..DC X50_Y-100..DC X44_Y-97..DC X42_Y-98..DC X43_Y-99..DC #> PDK4                0             0     0.000000     0.000000     0.000000 #> TNFRSF17            0             0     0.000000     0.000000     0.000000 #> ICAM3               0             0     4.029781     4.254824     1.424967 #> FAP                 0             0     0.000000     0.000000     0.000000 #> GZMB                0             0     0.000000     0.000000     0.000000 #> TSC2                0             0     0.000000     0.000000     0.000000 #>          X42_Y-102..DC X43_Y-100..DC X29_Y-91..Endothelial #> PDK4                 0             0             0.3263064 #> TNFRSF17             0             0             0.0000000 #> ICAM3                0             0             0.0000000 #> FAP                  0             0             0.6866956 #> GZMB                 0             0             0.0000000 #> TSC2                 0             0             0.0000000 #>          X24_Y-91..Endothelial X26_Y-91..Endothelial X24_Y-92..Endothelial #> PDK4                 0.7863651                     0             0.6553043 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.0000000                     0             0.0000000 #> GZMB                 0.0000000                     0             0.0000000 #> TSC2                 0.0000000                     0             0.0000000 #>          X29_Y-92..Endothelial X29_Y-93..Endothelial X30_Y-93..Endothelial #> PDK4                 0.2890709             0.6807583             0.7752843 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.7609970             0.0000000             0.0000000 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X24_Y-94..Endothelial X24_Y-95..Endothelial X28_Y-95..Endothelial #> PDK4                   1.01391              1.267388             1.1033435 #> TNFRSF17               0.00000              0.000000             0.0000000 #> ICAM3                  0.00000              0.000000             0.0000000 #> FAP                    0.00000              0.000000             0.6215519 #> GZMB                   0.00000              0.000000             0.0000000 #> TSC2                   0.00000              0.000000             0.0000000 #>          X27_Y-95..Endothelial X28_Y-96..Endothelial X27_Y-96..Endothelial #> PDK4                 1.5680964             1.2354310             1.4916799 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.2392100             0.6829458             0.1674470 #> GZMB                 0.2902074             0.2293006             0.2031452 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X26_Y-96..Endothelial X27_Y-97..Endothelial X28_Y-97..Endothelial #> PDK4                 1.5732845             0.6812293             1.3317520 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.2232626             0.7934868             0.8832670 #> GZMB                 0.0000000             0.0000000             0.2998546 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X24_Y-97..Endothelial X26_Y-97..Endothelial X28_Y-92..Endothelial #> PDK4                 1.4524192              2.034485              1.182641 #> TNFRSF17             0.0000000              0.000000              0.000000 #> ICAM3                0.0000000              0.000000              0.000000 #> FAP                  0.4085627              0.000000              2.057124 #> GZMB                 0.0000000              0.000000              0.000000 #> TSC2                 0.2213704              0.000000              0.000000 #>          X24_Y-98..Endothelial X65_Y-91..Endothelial X63_Y-91..Endothelial #> PDK4                 0.4300587             0.5698954                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.0000000             0.1755673                     0 #> GZMB                 0.0000000             0.1755673                     0 #> TSC2                 0.2418141             0.0000000                     0 #>          X66_Y-91..Endothelial X66_Y-92..Endothelial X61_Y-92..Endothelial #> PDK4                 0.8949568             0.5422553                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.1667890             0.2227792                     0 #> GZMB                 0.3457467             0.1789577                     0 #> TSC2                 0.0000000             0.0000000                     0 #>          X67_Y-92..Endothelial X62_Y-92..Endothelial X67_Y-93..Endothelial #> PDK4                 0.3548393                     0             0.4137505 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.4059865                     0             0.0000000 #> GZMB                 0.0000000                     0             0.0000000 #> TSC2                 0.0000000                     0             0.0000000 #>          X60_Y-93..Endothelial X63_Y-93..Endothelial X61_Y-94..Endothelial #> PDK4                  2.665872                     0              0.896915 #> TNFRSF17              0.000000                     0              0.000000 #> ICAM3                 0.000000                     0              0.000000 #> FAP                   0.000000                     0              0.000000 #> GZMB                  0.000000                     0              0.000000 #> TSC2                  0.000000                     0              0.000000 #>          X64_Y-96..Endothelial X65_Y-96..Endothelial X62_Y-96..Endothelial #> PDK4                 0.2660383                     0             0.3071172 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.2984125                     0             0.3039720 #> GZMB                 0.0000000                     0             0.0000000 #> TSC2                 0.0000000                     0             0.0000000 #>          X67_Y-96..Endothelial X61_Y-96..Endothelial X63_Y-96..Endothelial #> PDK4                 1.6836266             0.3992524             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.8914254             0.3951636             0.0000000 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.8914254             0.0000000             0.4822616 #>          X66_Y-96..Endothelial X63_Y-97..Endothelial X64_Y-97..Endothelial #> PDK4                  1.584402               0.00000               0.00000 #> TNFRSF17              0.000000               0.00000               0.00000 #> ICAM3                 0.000000               0.00000               0.00000 #> FAP                   0.000000               1.20599               1.20599 #> GZMB                  0.000000               0.00000               0.00000 #> TSC2                  0.000000               0.00000               0.00000 #>          X65_Y-98..Endothelial X64_Y-93..Endothelial X61_Y-93..Endothelial #> PDK4                 0.0000000                     0              0.896915 #> TNFRSF17             0.0000000                     0              0.000000 #> ICAM3                0.0000000                     0              0.000000 #> FAP                  0.8711444                     0              0.000000 #> GZMB                 0.0000000                     0              0.000000 #> TSC2                 0.0000000                     0              0.000000 #>          X63_Y-94..Endothelial X62_Y-94..Endothelial X64_Y-95..Endothelial #> PDK4                 0.9250144              1.541691             0.3144089 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.0000000              0.000000             0.3526693 #> GZMB                 0.0000000              0.000000             0.0000000 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X55_Y-91..Endothelial X58_Y-92..Endothelial X58_Y-93..Endothelial #> PDK4                 2.0473180              0.000000             0.8900206 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.5445555              3.721409             0.8900206 #> GZMB                 0.2421124              0.000000             0.0000000 #> TSC2                 0.2578671              0.000000             0.8900206 #>          X55_Y-93..Endothelial X59_Y-93..Endothelial X58_Y-94..Endothelial #> PDK4                 0.8319928              1.801583             1.4692927 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  1.8243206              0.000000             0.5340123 #> GZMB                 0.0000000              0.000000             0.0000000 #> TSC2                 0.0000000              0.000000             0.5340123 #>          X55_Y-95..Endothelial X59_Y-95..Endothelial X54_Y-95..Endothelial #> PDK4                         0              1.011567              0.000000 #> TNFRSF17                     0              0.000000              0.000000 #> ICAM3                        0              0.000000              0.000000 #> FAP                          0              0.000000              0.000000 #> GZMB                         0              0.000000              0.759852 #> TSC2                         0              0.000000              0.000000 #>          X58_Y-95..Endothelial X56_Y-95..Endothelial X56_Y-96..Endothelial #> PDK4                         0                     0              2.787984 #> TNFRSF17                     0                     0              0.000000 #> ICAM3                        0                     0              0.000000 #> FAP                          0                     0              0.000000 #> GZMB                         0                     0              1.083301 #> TSC2                         0                     0              0.000000 #>          X56_Y-97..Endothelial X75_Y-98..Endothelial X78_Y-98..Endothelial #> PDK4                 1.6027300                     0             0.6707283 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.3625463                     0             0.4975883 #> GZMB                 0.4814671                     0             0.0000000 #> TSC2                 0.0000000                     0             0.0000000 #>          X78_Y-99..Endothelial X78_Y-100..Endothelial X76_Y-100..Endothelial #> PDK4                 1.2232721                1.07779                      0 #> TNFRSF17             0.0000000                0.00000                      0 #> ICAM3                0.0000000                0.00000                      0 #> FAP                  0.2296562                0.00000                      0 #> GZMB                 0.0000000                0.00000                      0 #> TSC2                 0.0000000                0.00000                      0 #>          X76_Y-101..Endothelial X73_Y-101..Endothelial X78_Y-101..Endothelial #> PDK4                  0.8234747                      0                      0 #> TNFRSF17              0.0000000                      0                      0 #> ICAM3                 0.0000000                      0                      0 #> FAP                   0.7564919                      0                      0 #> GZMB                  0.0000000                      0                      0 #> TSC2                  0.0000000                      0                      0 #>          X73_Y-102..Endothelial X76_Y-102..Endothelial X77_Y-102..Endothelial #> PDK4                  0.6289972              0.6436798              0.3263064 #> TNFRSF17              0.0000000              0.0000000              0.0000000 #> ICAM3                 0.0000000              0.0000000              0.0000000 #> FAP                   0.0000000              0.4908489              0.0000000 #> GZMB                  0.6289972              0.4403334              0.3453873 #> TSC2                  0.0000000              0.0000000              0.0000000 #>          X76_Y-103..Endothelial X79_Y-98..Endothelial X75_Y-103..Endothelial #> PDK4                  0.4006007             0.9383771              0.2338305 #> TNFRSF17              0.0000000             0.0000000              0.0000000 #> ICAM3                 0.0000000             0.0000000              0.0000000 #> FAP                   0.0000000             0.3731913              0.0000000 #> GZMB                  0.2029701             0.0000000              0.2410270 #> TSC2                  0.0000000             0.0000000              0.0000000 #>          X75_Y-104..Endothelial X75_Y-85..Endothelial X75_Y-86..Endothelial #> PDK4                  0.0000000              1.040855              1.040855 #> TNFRSF17              0.0000000              0.000000              0.000000 #> ICAM3                 0.0000000              0.000000              0.000000 #> FAP                   0.0000000              0.000000              0.000000 #> GZMB                  0.7534725              0.000000              0.000000 #> TSC2                  0.0000000              0.000000              0.000000 #>          X78_Y-87..Endothelial X76_Y-87..Endothelial X77_Y-87..Endothelial #> PDK4                  3.694257             1.5516406             1.2929232 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   3.694257             0.4222984             0.4645283 #> GZMB                  0.000000             0.3790611             0.4169673 #> TSC2                  0.000000             0.4222984             0.4645283 #>          X78_Y-91..Endothelial X77_Y-91..Endothelial X78_Y-85..Endothelial #> PDK4                 0.9663610             0.9663610              1.123547 #> TNFRSF17             0.0000000             0.0000000              0.000000 #> ICAM3                0.0000000             0.0000000              0.000000 #> FAP                  0.0000000             0.0000000              0.000000 #> GZMB                 0.3439382             0.3439382              0.000000 #> TSC2                 0.0000000             0.0000000              0.000000 #>          X73_Y-85..Endothelial X33_Y-73..Endothelial X31_Y-73..Endothelial #> PDK4                         0             1.0687675              1.255199 #> TNFRSF17                     0             0.0000000              0.000000 #> ICAM3                        0             0.0000000              0.000000 #> FAP                          0             0.2442264              0.000000 #> GZMB                         0             0.0000000              0.000000 #> TSC2                         0             0.3278334              0.000000 #>          X32_Y-74..Endothelial X31_Y-74..Endothelial X35_Y-77..Endothelial #> PDK4                 0.9806495             0.5090745              1.644347 #> TNFRSF17             0.0000000             0.0000000              0.000000 #> ICAM3                0.0000000             0.0000000              0.000000 #> FAP                  0.0000000             0.0000000              0.000000 #> GZMB                 0.0000000             0.0000000              0.000000 #> TSC2                 0.0000000             0.0000000              0.000000 #>          X35_Y-78..Endothelial X30_Y-78..Endothelial X36_Y-79..Endothelial #> PDK4                 0.7870859             0.7042003             0.8540386 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.3341206             0.0000000             0.5042380 #> GZMB                 0.0000000             0.0000000             0.5305103 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X31_Y-72..Endothelial X30_Y-72..Endothelial X33_Y-72..Endothelial #> PDK4                 0.3996139             0.8063748             0.7926146 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.0000000             0.0000000 #> GZMB                 0.2521216             0.2653912             0.0000000 #> TSC2                 0.0000000             0.1779634             0.3278334 #>          X32_Y-73..Endothelial X30_Y-73..Endothelial X30_Y-74..Endothelial #> PDK4                 0.7119730             1.2930691             0.6941926 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.3256353             0.0000000             0.0000000 #> GZMB                 0.3404694             0.0000000             0.0000000 #> TSC2                 0.3221282             0.3757004             0.0000000 #>          X34_Y-78..Endothelial X30_Y-79..Endothelial X35_Y-79..Endothelial #> PDK4                 0.9681625              1.638518             0.8595992 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.4594158              0.000000             1.0015582 #> GZMB                 0.0000000              0.000000             0.0000000 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X37_Y-67..Endothelial X42_Y-67..Endothelial X41_Y-68..Endothelial #> PDK4                         0               1.43662             0.3956705 #> TNFRSF17                     0               0.00000             0.0000000 #> ICAM3                        0               0.00000             0.0000000 #> FAP                          0               0.00000             0.6531360 #> GZMB                         0               0.00000             0.0000000 #> TSC2                         0               0.00000             0.0000000 #>          X35_Y-68..Endothelial X41_Y-69..Endothelial X39_Y-69..Endothelial #> PDK4                  0.000000             1.1325629             0.9541226 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   1.720393             0.8476295             0.9541226 #> GZMB                  0.000000             0.0000000             0.0000000 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X40_Y-69..Endothelial X35_Y-69..Endothelial X38_Y-71..Endothelial #> PDK4                  1.510084                     0             0.0000000 #> TNFRSF17              0.000000                     0             0.0000000 #> ICAM3                 0.000000                     0             0.0000000 #> FAP                   0.499083                     0             0.0000000 #> GZMB                  0.000000                     0             0.2945862 #> TSC2                  0.000000                     0             0.0000000 #>          X39_Y-71..Endothelial X40_Y-71..Endothelial X40_Y-72..Endothelial #> PDK4                  0.000000              1.015642              1.304263 #> TNFRSF17              0.000000              0.000000              0.000000 #> ICAM3                 0.000000              0.000000              0.000000 #> FAP                   0.000000              0.000000              0.000000 #> GZMB                  0.382962              0.000000              0.000000 #> TSC2                  0.000000              0.000000              0.000000 #>          X38_Y-72..Endothelial X39_Y-73..Endothelial X40_Y-73..Endothelial #> PDK4                 0.1363459             0.8916219             0.5922064 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.1509120             0.4192954             0.0000000 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X41_Y-67..Endothelial X42_Y-68..Endothelial X39_Y-70..Endothelial #> PDK4                  1.374147             0.8025693               0.00000 #> TNFRSF17              0.000000             0.0000000               0.00000 #> ICAM3                 0.000000             0.0000000               0.00000 #> FAP                   0.000000             0.0000000               0.00000 #> GZMB                  0.000000             0.0000000               0.63827 #> TSC2                  0.000000             0.0000000               0.00000 #>          X39_Y-72..Endothelial X38_Y-73..Endothelial X37_Y-73..Endothelial #> PDK4                  0.989385             1.6258524             1.2512386 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             0.3589168             0.4277305 #> GZMB                  0.000000             0.0000000             0.3388970 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X37_Y-74..Endothelial X38_Y-74..Endothelial X39_Y-74..Endothelial #> PDK4                 0.6996443             0.9270162             2.8871844 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.2592460             0.6945588             0.8241521 #> GZMB                 0.4518627             0.5213800             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X41_Y-75..Endothelial X38_Y-75..Endothelial X40_Y-75..Endothelial #> PDK4                 0.5918616              1.736219             0.7498636 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.7381426              1.785285             0.3700352 #> GZMB                 0.0000000              0.000000             0.0000000 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X39_Y-75..Endothelial X37_Y-75..Endothelial X38_Y-76..Endothelial #> PDK4                 1.4838463             0.8694723             0.2206591 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.2735358             0.1803323             0.4764148 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X37_Y-76..Endothelial X39_Y-76..Endothelial X42_Y-77..Endothelial #> PDK4                 0.4986333              1.237822             1.2620858 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.1868640              0.000000             0.6658778 #> GZMB                 0.0000000              0.000000             0.0000000 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X37_Y-77..Endothelial X41_Y-78..Endothelial X42_Y-78..Endothelial #> PDK4                 0.5480896              0.000000             1.6506942 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.3453042              4.686998             0.0000000 #> GZMB                 0.0000000              0.000000             0.2330819 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X38_Y-78..Endothelial X40_Y-78..Endothelial X36_Y-78..Endothelial #> PDK4                 0.4360977              1.641654             0.0000000 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.0000000              0.000000             0.7102070 #> GZMB                 0.0000000              0.000000             0.3713572 #> TSC2                 0.0000000              0.000000             0.4520800 #>          X39_Y-78..Endothelial X37_Y-78..Endothelial X79_Y-78..Endothelial #> PDK4                 2.0915196              1.812714                     0 #> TNFRSF17             0.0000000              0.000000                     0 #> ICAM3                0.0000000              0.000000                     0 #> FAP                  0.3912929              1.616597                     0 #> GZMB                 0.0000000              0.000000                     0 #> TSC2                 0.0000000              0.000000                     0 #>          X75_Y-73..Endothelial X76_Y-73..Endothelial X73_Y-73..Endothelial #> PDK4                 0.4126319                     0              1.416312 #> TNFRSF17             0.0000000                     0              0.000000 #> ICAM3                0.0000000                     0              0.000000 #> FAP                  0.0000000                     0              0.000000 #> GZMB                 0.0000000                     0              0.000000 #> TSC2                 0.0000000                     0              0.000000 #>          X75_Y-74..Endothelial X76_Y-74..Endothelial X73_Y-74..Endothelial #> PDK4                  1.209938                     0              2.127412 #> TNFRSF17              0.000000                     0              0.000000 #> ICAM3                 0.000000                     0              0.000000 #> FAP                   0.000000                     0              0.000000 #> GZMB                  0.000000                     0              0.000000 #> TSC2                  0.000000                     0              0.000000 #>          X75_Y-75..Endothelial X74_Y-75..Endothelial X76_Y-75..Endothelial #> PDK4                  1.561007             0.4749075              0.000000 #> TNFRSF17              0.000000             0.0000000              0.000000 #> ICAM3                 0.000000             0.0000000              0.000000 #> FAP                   1.211063             0.5768901              0.000000 #> GZMB                  0.000000             0.4939545              0.000000 #> TSC2                  0.000000             0.0000000              2.066379 #>          X78_Y-75..Endothelial X78_Y-76..Endothelial X75_Y-76..Endothelial #> PDK4                 0.9999217             0.4444671             1.6608412 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.0000000             0.6359124 #> GZMB                 1.1016603             0.9639527             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X74_Y-76..Endothelial X73_Y-76..Endothelial X75_Y-77..Endothelial #> PDK4                 1.0719422              1.127529                     0 #> TNFRSF17             0.0000000              0.000000                     0 #> ICAM3                0.0000000              0.000000                     0 #> FAP                  0.3868022              0.000000                     0 #> GZMB                 0.3592396              0.000000                     0 #> TSC2                 0.0000000              0.000000                     0 #>          X73_Y-77..Endothelial X78_Y-77..Endothelial X73_Y-78..Endothelial #> PDK4                  1.002248               2.61249             0.7358347 #> TNFRSF17              0.000000               0.00000             0.0000000 #> ICAM3                 0.000000               0.00000             0.0000000 #> FAP                   0.000000               0.00000             0.3862604 #> GZMB                  0.000000               0.00000             0.0000000 #> TSC2                  0.000000               0.00000             0.0000000 #>          X77_Y-78..Endothelial X78_Y-78..Endothelial X76_Y-79..Endothelial #> PDK4                  0.000000             0.0000000             1.6191279 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             0.0000000             0.6363983 #> GZMB                  0.585096             0.8352553             0.0000000 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X78_Y-79..Endothelial X76_Y-72..Endothelial X73_Y-72..Endothelial #> PDK4                  1.120763             0.7995658             0.6742129 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             0.0000000             0.6266542 #> GZMB                  0.000000             0.0000000             0.0000000 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X77_Y-73..Endothelial X65_Y-70..Endothelial X62_Y-70..Endothelial #> PDK4                         0             0.8097657                     0 #> TNFRSF17                     0             0.0000000                     0 #> ICAM3                        0             0.0000000                     0 #> FAP                          0             0.0000000                     0 #> GZMB                         0             1.0759916                     0 #> TSC2                         0             0.0000000                     0 #>          X63_Y-70..Endothelial X64_Y-70..Endothelial X61_Y-70..Endothelial #> PDK4                         0              1.760947             0.7523182 #> TNFRSF17                     0              0.000000             0.0000000 #> ICAM3                        0              0.000000             0.0000000 #> FAP                          0              0.000000             0.7335717 #> GZMB                         0              0.661493             0.0000000 #> TSC2                         0              0.000000             0.0000000 #>          X62_Y-71..Endothelial X63_Y-71..Endothelial X65_Y-71..Endothelial #> PDK4                         0             0.8206074              1.034704 #> TNFRSF17                     0             0.0000000              0.000000 #> ICAM3                        0             0.0000000              0.000000 #> FAP                          0             0.0000000              0.000000 #> GZMB                         0             0.0000000              1.075992 #> TSC2                         0             0.0000000              0.000000 #>          X64_Y-72..Endothelial X65_Y-72..Endothelial X62_Y-73..Endothelial #> PDK4                         0                     0                     0 #> TNFRSF17                     0                     0                     0 #> ICAM3                        0                     0                     0 #> FAP                          0                     0                     0 #> GZMB                         0                     0                     0 #> TSC2                         0                     0                     0 #>          X63_Y-74..Endothelial X67_Y-74..Endothelial X65_Y-75..Endothelial #> PDK4                         0                     0             1.2223834 #> TNFRSF17                     0                     0             0.0000000 #> ICAM3                        0                     0             0.0000000 #> FAP                          0                     0             0.4637097 #> GZMB                         0                     0             0.0000000 #> TSC2                         0                     0             0.4163208 #>          X66_Y-76..Endothelial X66_Y-77..Endothelial X67_Y-77..Endothelial #> PDK4                 0.3378579             1.0417412             0.6864135 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.8587407             0.2511868             0.6154713 #> GZMB                 0.4465543             0.4927830             0.6065021 #> TSC2                 0.3700630             0.1595077             0.0000000 #>          X63_Y-73..Endothelial X66_Y-73..Endothelial X65_Y-74..Endothelial #> PDK4                         0                     0              1.985932 #> TNFRSF17                     0                     0              0.000000 #> ICAM3                        0                     0              0.000000 #> FAP                          0                     0              0.000000 #> GZMB                         0                     0              1.985932 #> TSC2                         0                     0              0.000000 #>          X64_Y-74..Endothelial X65_Y-76..Endothelial X64_Y-76..Endothelial #> PDK4                  2.663617             1.2223834              0.000000 #> TNFRSF17              0.000000             0.0000000              0.000000 #> ICAM3                 0.000000             0.0000000              0.000000 #> FAP                   0.000000             0.4637097              0.000000 #> GZMB                  1.323954             0.0000000              0.000000 #> TSC2                  0.000000             0.4163208              4.318475 #>          X72_Y-73..Endothelial X69_Y-75..Endothelial X69_Y-76..Endothelial #> PDK4                   3.94168             0.0000000             0.4159964 #> TNFRSF17               0.00000             0.0000000             0.0000000 #> ICAM3                  0.00000             0.0000000             0.0000000 #> FAP                    0.00000             0.4803665             0.0000000 #> GZMB                   0.00000             0.0000000             0.0000000 #> TSC2                   0.00000             0.0000000             0.0000000 #>          X68_Y-76..Endothelial X70_Y-76..Endothelial X72_Y-76..Endothelial #> PDK4                  2.006819                     0              2.317191 #> TNFRSF17              0.000000                     0              0.000000 #> ICAM3                 0.000000                     0              0.000000 #> FAP                   0.000000                     0              0.000000 #> GZMB                  0.000000                     0              0.000000 #> TSC2                  0.000000                     0              0.000000 #>          X72_Y-77..Endothelial X71_Y-77..Endothelial X70_Y-77..Endothelial #> PDK4                 0.4099985             0.4447803                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.0000000             0.0000000                     0 #> GZMB                 0.0000000             0.0000000                     0 #> TSC2                 0.0000000             0.0000000                     0 #>          X70_Y-78..Endothelial X71_Y-78..Endothelial X73_Y-79..Endothelial #> PDK4                  2.006819                     0              1.103752 #> TNFRSF17              0.000000                     0              0.000000 #> ICAM3                 0.000000                     0              0.000000 #> FAP                   0.000000                     0              0.000000 #> GZMB                  0.000000                     0              0.000000 #> TSC2                  0.000000                     0              0.000000 #>          X70_Y-79..Endothelial X71_Y-79..Endothelial X72_Y-74..Endothelial #> PDK4                 1.1986874              1.398362              2.732168 #> TNFRSF17             0.0000000              0.000000              0.000000 #> ICAM3                0.0000000              0.000000              0.000000 #> FAP                  0.0000000              0.000000              0.000000 #> GZMB                 0.4355722              0.000000              0.000000 #> TSC2                 0.0000000              0.000000              0.000000 #>          X71_Y-74..Endothelial X58_Y-73..Endothelial X57_Y-73..Endothelial #> PDK4                         0             0.8496557             0.8119029 #> TNFRSF17                     0             0.0000000             0.0000000 #> ICAM3                        0             0.0000000             0.0000000 #> FAP                          0             0.4233368             0.2877191 #> GZMB                         0             0.1476121             0.3112437 #> TSC2                         0             0.0000000             0.1333782 #>          X57_Y-74..Endothelial X59_Y-75..Endothelial X60_Y-75..Endothelial #> PDK4                 0.4884197             0.5071364             0.5071364 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.2300295             0.2487942             0.2487942 #> GZMB                 0.2337595             0.0000000             0.0000000 #> TSC2                 0.4205697             0.0000000             0.0000000 #>          X58_Y-75..Endothelial X59_Y-76..Endothelial X58_Y-76..Endothelial #> PDK4                 0.6273057             0.9562942             0.3568031 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.0000000             0.0000000 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X54_Y-77..Endothelial X54_Y-78..Endothelial X55_Y-78..Endothelial #> PDK4                 0.6566938             0.8621751             0.3444224 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.3902681             0.4601614             1.1201001 #> GZMB                 0.2821430             0.4798245             0.8724082 #> TSC2                 0.2915969             0.1895380             0.0000000 #>          X55_Y-79..Endothelial X54_Y-79..Endothelial X58_Y-74..Endothelial #> PDK4                 1.0141077             0.4463157             0.5061955 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.2332959             0.3955178 #> GZMB                 0.5196002             0.2338201             0.0000000 #> TSC2                 0.0000000             0.2343499             0.3925318 #>          X68_Y-66..Endothelial X68_Y-67..Endothelial X68_Y-68..Endothelial #> PDK4                         0             0.6030263              0.527648 #> TNFRSF17                     0             0.0000000              0.000000 #> ICAM3                        0             0.0000000              0.000000 #> FAP                          0             0.0000000              0.000000 #> GZMB                         0             0.0000000              0.000000 #> TSC2                         0             0.0000000              0.000000 #>          X73_Y-68..Endothelial X71_Y-68..Endothelial X69_Y-68..Endothelial #> PDK4                  1.132458             0.9364599             0.8442368 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             0.0000000             0.0000000 #> GZMB                  0.000000             0.0000000             0.0000000 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X72_Y-68..Endothelial X68_Y-69..Endothelial X71_Y-69..Endothelial #> PDK4                  2.497226             0.7052915             0.7530552 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             0.0000000             0.2296562 #> GZMB                  0.000000             0.0000000             0.2715128 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X72_Y-69..Endothelial X68_Y-70..Endothelial X69_Y-70..Endothelial #> PDK4                 0.8158098              1.175486             2.6496611 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.2487942              1.332586             0.4049601 #> GZMB                 0.2941389              0.000000             0.0000000 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X70_Y-70..Endothelial X69_Y-71..Endothelial X70_Y-71..Endothelial #> PDK4                 2.5769900             2.6496611             2.5769900 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.3149689             0.4049601             0.3149689 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X67_Y-71..Endothelial X68_Y-72..Endothelial X73_Y-66..Endothelial #> PDK4                  0.000000                     0             0.4002166 #> TNFRSF17              0.000000                     0             0.0000000 #> ICAM3                 0.000000                     0             0.0000000 #> FAP                   1.329106                     0             0.4290446 #> GZMB                  0.000000                     0             0.0000000 #> TSC2                  0.000000                     0             0.3994954 #>          X73_Y-67..Endothelial X69_Y-72..Endothelial X54_Y-72..Endothelial #> PDK4                 0.9668519                     0                     0 #> TNFRSF17             0.0000000                     0                     0 #> ICAM3                0.0000000                     0                     0 #> FAP                  0.4719490                     0                     0 #> GZMB                 0.0000000                     0                     0 #> TSC2                 0.0000000                     0                     0 #>          X52_Y-73..Endothelial X51_Y-73..Endothelial X49_Y-73..Endothelial #> PDK4                  0.000000             0.8651222              4.182296 #> TNFRSF17              0.000000             0.0000000              0.000000 #> ICAM3                 0.000000             0.0000000              0.000000 #> FAP                   1.152782             0.5669179              0.000000 #> GZMB                  0.594137             0.5947178              0.000000 #> TSC2                  0.000000             0.0000000              0.000000 #>          X50_Y-73..Endothelial X50_Y-74..Endothelial X53_Y-74..Endothelial #> PDK4                  1.640278              0.608304                     0 #> TNFRSF17              0.000000              0.000000                     0 #> ICAM3                 0.000000              0.000000                     0 #> FAP                   0.000000              0.000000                     0 #> GZMB                  0.000000              0.000000                     0 #> TSC2                  0.000000              0.000000                     0 #>          X52_Y-74..Endothelial X51_Y-74..Endothelial X53_Y-75..Endothelial #> PDK4                 0.0000000             1.2722463             1.2019316 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.0000000             0.5921297 #> GZMB                 0.8853154             0.3457069             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X54_Y-75..Endothelial X53_Y-76..Endothelial X48_Y-77..Endothelial #> PDK4                 1.6796437             1.5298431                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.5181135             0.5181135                     0 #> GZMB                 0.0000000             0.4584823                     0 #> TSC2                 0.3718606             0.0000000                     0 #>          X53_Y-78..Endothelial X51_Y-78..Endothelial X52_Y-78..Endothelial #> PDK4                  1.672713             0.4728577             0.4728577 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             0.4728577             0.4728577 #> GZMB                  0.000000             0.4728577             0.4728577 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X54_Y-76..Endothelial X49_Y-79..Endothelial X50_Y-79..Endothelial #> PDK4                 0.0000000              1.090686                     0 #> TNFRSF17             0.0000000              0.000000                     0 #> ICAM3                0.0000000              0.000000                     0 #> FAP                  0.8455810              0.000000                     0 #> GZMB                 0.6113098              0.000000                     0 #> TSC2                 0.0000000              0.000000                     0 #>          X44_Y-91..Endothelial X43_Y-91..Endothelial X47_Y-92..Endothelial #> PDK4                 0.0000000              0.949815             0.6197871 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.5486861              0.000000             0.0000000 #> GZMB                 0.0000000              0.000000             0.0000000 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X44_Y-92..Endothelial X46_Y-92..Endothelial X42_Y-93..Endothelial #> PDK4                 0.2902074             0.4426577             0.7431380 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.5855210             0.0000000             0.7480543 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X43_Y-93..Endothelial X42_Y-94..Endothelial X43_Y-94..Endothelial #> PDK4                  0.000000             0.5812126             0.3539842 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   1.047037             0.4079932             0.7720089 #> GZMB                  0.000000             0.0000000             0.0000000 #> TSC2                  0.000000             0.2120614             0.0000000 #>          X46_Y-94..Endothelial X43_Y-95..Endothelial X48_Y-95..Endothelial #> PDK4                         0             0.0000000              0.000000 #> TNFRSF17                     0             0.0000000              0.000000 #> ICAM3                        0             0.0000000              0.000000 #> FAP                          0             0.9629777              0.000000 #> GZMB                         0             0.0000000              1.260778 #> TSC2                         0             0.0000000              0.000000 #>          X41_Y-95..Endothelial X43_Y-96..Endothelial X45_Y-96..Endothelial #> PDK4                  2.009691             0.2684563             0.1985126 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             0.7593920             0.0000000 #> GZMB                  0.000000             0.0000000             0.2407422 #> TSC2                  0.000000             0.2278723             0.0000000 #>          X42_Y-96..Endothelial X44_Y-96..Endothelial X45_Y-97..Endothelial #> PDK4                 0.9355264             0.0000000             0.2779176 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.8243603             0.4517058             0.0000000 #> GZMB                 0.0000000             0.0000000             0.3370391 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X47_Y-96..Endothelial X43_Y-97..Endothelial X46_Y-97..Endothelial #> PDK4                         0             0.5849136             0.6232818 #> TNFRSF17                     0             0.0000000             0.0000000 #> ICAM3                        0             0.0000000             0.0000000 #> FAP                          0             0.5567975             0.0000000 #> GZMB                         0             0.0000000             0.0000000 #> TSC2                         0             0.1841427             0.0000000 #>          X47_Y-97..Endothelial X42_Y-97..Endothelial X45_Y-91..Endothelial #> PDK4                   0.34496             0.2271161             0.0000000 #> TNFRSF17               0.00000             0.0000000             0.0000000 #> ICAM3                  0.00000             0.0000000             0.0000000 #> FAP                    0.00000             0.8584231             0.7105898 #> GZMB                   0.00000             0.2562189             0.0000000 #> TSC2                   0.00000             0.2166384             0.0000000 #>          X45_Y-92..Endothelial X42_Y-95..Endothelial X44_Y-97..Endothelial #> PDK4                         0             1.1825303             0.7549723 #> TNFRSF17                     0             0.0000000             0.0000000 #> ICAM3                        0             0.0000000             0.0000000 #> FAP                          0             0.7240133             0.0000000 #> GZMB                         0             0.0000000             0.0000000 #> TSC2                         0             0.0000000             0.0000000 #>          X43_Y-98..Endothelial X23_Y-77..Endothelial X22_Y-77..Endothelial #> PDK4                 0.0000000              1.256729              4.382669 #> TNFRSF17             0.0000000              0.000000              0.000000 #> ICAM3                0.0000000              0.000000              0.000000 #> FAP                  0.2590567              0.000000              0.000000 #> GZMB                 0.0000000              0.000000              0.000000 #> TSC2                 0.0000000              0.000000              0.000000 #>          X24_Y-78..Endothelial X23_Y-78..Endothelial X22_Y-78..Endothelial #> PDK4                 0.8384455              1.340511              1.436262 #> TNFRSF17             0.0000000              0.000000              0.000000 #> ICAM3                0.0000000              0.000000              0.000000 #> FAP                  0.6547753              0.000000              0.000000 #> GZMB                 0.2922508              0.000000              0.000000 #> TSC2                 0.0000000              0.000000              0.000000 #>          X22_Y-79..Endothelial X24_Y-77..Endothelial X25_Y-73..Endothelial #> PDK4                 1.6453959             0.3574726             2.1650842 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.3598729             0.6296916 #> GZMB                 0.3115812             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X26_Y-73..Endothelial X25_Y-74..Endothelial X24_Y-74..Endothelial #> PDK4                  1.231234              1.175907              0.000000 #> TNFRSF17              0.000000              0.000000              0.000000 #> ICAM3                 0.000000              0.000000              0.000000 #> FAP                   0.000000              0.000000              0.000000 #> GZMB                  0.000000              0.000000              0.000000 #> TSC2                  0.000000              0.000000              0.723442 #>          X24_Y-75..Endothelial X25_Y-75..Endothelial X25_Y-76..Endothelial #> PDK4                 0.7564919             0.9077902              1.062157 #> TNFRSF17             0.0000000             0.0000000              0.000000 #> ICAM3                0.0000000             0.0000000              0.000000 #> FAP                  0.0000000             0.0000000              0.000000 #> GZMB                 0.0000000             0.0000000              0.000000 #> TSC2                 0.7234420             0.8681304              0.000000 #>          X25_Y-77..Endothelial X26_Y-72..Endothelial X29_Y-72..Endothelial #> PDK4                 0.3574726              1.153207              2.810484 #> TNFRSF17             0.0000000              0.000000              0.000000 #> ICAM3                0.0000000              0.000000              0.000000 #> FAP                  0.3598729              0.000000              1.168099 #> GZMB                 0.0000000              0.000000              0.000000 #> TSC2                 0.0000000              0.000000              0.000000 #>          X24_Y-72..Endothelial X24_Y-73..Endothelial X26_Y-76..Endothelial #> PDK4                   1.87629             2.1449660                     0 #> TNFRSF17               0.00000             0.0000000                     0 #> ICAM3                  0.00000             0.0000000                     0 #> FAP                    0.00000             0.4722687                     0 #> GZMB                   0.00000             0.0000000                     0 #> TSC2                   0.00000             0.0000000                     0 #>          X25_Y-78..Endothelial X25_Y-79..Endothelial X24_Y-79..Endothelial #> PDK4                 0.5344367             1.0725816             0.9347402 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.6080056             0.2716813             0.3169616 #> GZMB                 0.2713757             0.2713757             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X26_Y-79..Endothelial X34_Y-67..Endothelial X30_Y-70..Endothelial #> PDK4                         0                     0                     0 #> TNFRSF17                     0                     0                     0 #> ICAM3                        0                     0                     0 #> FAP                          0                     0                     0 #> GZMB                         0                     0                     0 #> TSC2                         0                     0                     0 #>          X33_Y-70..Endothelial X35_Y-70..Endothelial X34_Y-70..Endothelial #> PDK4                  0.000000             1.2894122              1.031530 #> TNFRSF17              0.000000             0.0000000              0.000000 #> ICAM3                 0.000000             0.0000000              0.000000 #> FAP                   0.000000             0.0000000              0.000000 #> GZMB                  0.000000             0.4872638              0.389811 #> TSC2                  2.411979             0.0000000              0.000000 #>          X34_Y-71..Endothelial X32_Y-72..Endothelial X33_Y-67..Endothelial #> PDK4                 0.7607077              0.514738              4.311194 #> TNFRSF17             0.0000000              0.000000              0.000000 #> ICAM3                0.0000000              0.000000              0.000000 #> FAP                  0.0000000              0.000000              0.000000 #> GZMB                 0.7796220              0.000000              0.000000 #> TSC2                 0.0000000              0.000000              0.000000 #>          X30_Y-68..Endothelial X31_Y-70..Endothelial X31_Y-71..Endothelial #> PDK4                  2.549573              4.333887             0.6652454 #> TNFRSF17              0.000000              0.000000             0.0000000 #> ICAM3                 0.000000              0.000000             0.0000000 #> FAP                   0.000000              0.000000             0.0000000 #> GZMB                  0.000000              0.000000             0.2801351 #> TSC2                  0.000000              0.000000             0.0000000 #>          X33_Y-71..Endothelial X30_Y-71..Endothelial X33_Y-65..Endothelial #> PDK4                 0.0000000             0.5916781              3.464477 #> TNFRSF17             0.0000000             0.0000000              0.000000 #> ICAM3                0.0000000             0.0000000              0.000000 #> FAP                  0.8523389             0.0000000              0.000000 #> GZMB                 0.0000000             0.0000000              0.000000 #> TSC2                 0.0000000             0.0000000              0.000000 #>          X36_Y-80..Endothelial X30_Y-80..Endothelial X35_Y-80..Endothelial #> PDK4                 0.6195601              2.018057             2.0764464 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.0000000              0.000000             0.3081741 #> GZMB                 0.0000000              0.000000             0.0000000 #> TSC2                 0.0000000              0.000000             0.3041201 #>          X35_Y-81..Endothelial X36_Y-81..Endothelial X34_Y-81..Endothelial #> PDK4                 1.1151915             0.3862895             0.9235643 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.4426129             0.0000000 #> GZMB                 0.2113077             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X35_Y-82..Endothelial X34_Y-82..Endothelial X35_Y-83..Endothelial #> PDK4                 0.5819524              1.661536             0.4766301 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.0000000              0.000000             0.0000000 #> GZMB                 0.1828383              0.000000             0.0000000 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X36_Y-83..Endothelial X30_Y-84..Endothelial X30_Y-85..Endothelial #> PDK4                 0.8388638               1.20701             0.5450324 #> TNFRSF17             0.0000000               0.00000             0.0000000 #> ICAM3                0.0000000               0.00000             0.0000000 #> FAP                  0.2175929               0.00000             0.0000000 #> GZMB                 0.0000000               0.00000             0.0000000 #> TSC2                 0.0000000               0.00000             0.0000000 #>          X31_Y-85..Endothelial X33_Y-81..Endothelial X36_Y-82..Endothelial #> PDK4                 0.9353892                     0             0.3561442 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.0000000                     0             0.2048600 #> GZMB                 0.0000000                     0             0.1828383 #> TSC2                 0.0000000                     0             0.0000000 #>          X34_Y-83..Endothelial X34_Y-84..Endothelial X29_Y-84..Endothelial #> PDK4                 0.8914254             0.8914254              1.295232 #> TNFRSF17             0.0000000             0.0000000              0.000000 #> ICAM3                0.0000000             0.0000000              0.000000 #> FAP                  0.0000000             0.0000000              0.000000 #> GZMB                 0.0000000             0.0000000              0.000000 #> TSC2                 0.8914254             0.8914254              0.000000 #>          X32_Y-85..Endothelial X38_Y-64..Endothelial X38_Y-65..Endothelial #> PDK4                         0              3.914820                     0 #> TNFRSF17                     0              0.000000                     0 #> ICAM3                        0              0.000000                     0 #> FAP                          0              3.241421                     0 #> GZMB                         0              0.000000                     0 #> TSC2                         0              0.000000                     0 #>          X38_Y-66..Endothelial X36_Y-66..Endothelial X42_Y-66..Endothelial #> PDK4                         0              1.573619              1.389913 #> TNFRSF17                     0              0.000000              0.000000 #> ICAM3                        0              0.000000              0.000000 #> FAP                          0              0.000000              0.000000 #> GZMB                         0              0.000000              0.000000 #> TSC2                         0              0.000000              0.000000 #>          X23_Y-67..Endothelial X24_Y-67..Endothelial X22_Y-68..Endothelial #> PDK4                  1.164795             0.9416899             2.2356393 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             0.2006819             0.0000000 #> GZMB                  0.000000             0.2057408             0.0000000 #> TSC2                  0.000000             0.0000000             0.1687916 #>          X23_Y-68..Endothelial X21_Y-68..Endothelial X22_Y-69..Endothelial #> PDK4                   2.01414             1.9832642             2.4821051 #> TNFRSF17               0.00000             0.0000000             0.0000000 #> ICAM3                  0.00000             0.0000000             0.0000000 #> FAP                    0.00000             0.0000000             0.0000000 #> GZMB                   0.00000             0.0000000             0.0000000 #> TSC2                   0.00000             0.4219789             0.1875462 #>          X23_Y-69..Endothelial X22_Y-72..Endothelial X29_Y-80..Endothelial #> PDK4                  1.974855             0.9796744                     0 #> TNFRSF17              0.000000             0.0000000                     0 #> ICAM3                 0.000000             0.0000000                     0 #> FAP                   0.000000             0.0000000                     0 #> GZMB                  0.000000             0.0000000                     0 #> TSC2                  0.000000             0.0000000                     0 #>          X25_Y-81..Endothelial X26_Y-81..Endothelial X26_Y-82..Endothelial #> PDK4                  4.635125             0.8159799             0.0000000 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             1.0416984             0.7440703 #> GZMB                  0.000000             0.0000000             0.0000000 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X23_Y-82..Endothelial X28_Y-82..Endothelial X27_Y-82..Endothelial #> PDK4                 0.0000000             0.0000000             0.8543770 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.6516754             0.6034497             0.7902847 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.7447139             0.4964759 #>          X28_Y-83..Endothelial X27_Y-83..Endothelial X28_Y-84..Endothelial #> PDK4                 0.8607599             1.2815655             0.4379644 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.3620698             0.5819774             0.0000000 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.4468283             0.0000000             0.0000000 #>          X26_Y-84..Endothelial X26_Y-85..Endothelial X23_Y-79..Endothelial #> PDK4                  0.984185             0.9664662             1.0262621 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.957405             0.0000000             0.0000000 #> GZMB                  0.000000             0.0000000             0.6363843 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X24_Y-80..Endothelial X23_Y-81..Endothelial X24_Y-81..Endothelial #> PDK4                 0.6928685             0.2359745                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.0000000             0.0000000                     0 #> GZMB                 0.0000000             0.2009494                     0 #> TSC2                 0.0000000             0.2359745                     0 #>          X26_Y-83..Endothelial X24_Y-83..Endothelial X24_Y-84..Endothelial #> PDK4                  0.984185                     0                     0 #> TNFRSF17              0.000000                     0                     0 #> ICAM3                 0.000000                     0                     0 #> FAP                   0.957405                     0                     0 #> GZMB                  0.000000                     0                     0 #> TSC2                  0.000000                     0                     0 #>          X28_Y-85..Endothelial X29_Y-85..Endothelial X25_Y-66..Endothelial #> PDK4                  1.446364              1.285657             1.1652032 #> TNFRSF17              0.000000              0.000000             0.0000000 #> ICAM3                 0.000000              0.000000             0.0000000 #> FAP                   0.000000              0.000000             0.0000000 #> GZMB                  0.000000              0.000000             0.5549608 #> TSC2                  0.000000              0.000000             0.0000000 #>          X24_Y-66..Endothelial X25_Y-67..Endothelial X28_Y-67..Endothelial #> PDK4                 1.1119622             1.1119622              1.544472 #> TNFRSF17             0.0000000             0.0000000              0.000000 #> ICAM3                0.0000000             0.0000000              0.000000 #> FAP                  0.0000000             0.0000000              0.000000 #> GZMB                 0.5549608             0.5549608              0.000000 #> TSC2                 0.0000000             0.0000000              0.000000 #>          X27_Y-67..Endothelial X25_Y-68..Endothelial X26_Y-68..Endothelial #> PDK4                 0.9464191              1.813065             1.0882531 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.0000000              0.000000             0.0000000 #> GZMB                 0.0000000              0.000000             0.1583313 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X29_Y-68..Endothelial X28_Y-68..Endothelial X27_Y-68..Endothelial #> PDK4                 1.6343346                     0              1.318438 #> TNFRSF17             0.0000000                     0              0.000000 #> ICAM3                0.0000000                     0              0.000000 #> FAP                  0.0000000                     0              0.000000 #> GZMB                 0.4404075                     0              0.000000 #> TSC2                 0.0000000                     0              0.000000 #>          X25_Y-69..Endothelial X25_Y-70..Endothelial X26_Y-70..Endothelial #> PDK4                 0.4864134             0.4864134             0.9078801 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.0000000             0.3142794 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X29_Y-70..Endothelial X23_Y-71..Endothelial X29_Y-71..Endothelial #> PDK4                  1.791037              2.815324             1.5012954 #> TNFRSF17              0.000000              0.000000             0.0000000 #> ICAM3                 0.000000              0.000000             0.0000000 #> FAP                   0.000000              0.000000             0.0000000 #> GZMB                  1.132890              0.000000             0.7209299 #> TSC2                  0.000000              0.000000             0.0000000 #>          X26_Y-71..Endothelial X28_Y-71..Endothelial X28_Y-72..Endothelial #> PDK4                 0.9640177             0.7978866             0.7999609 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.2403313             0.0000000             0.0000000 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X25_Y-72..Endothelial X26_Y-67..Endothelial X22_Y-80..Endothelial #> PDK4                  1.520061             0.9131944             0.4491191 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             0.0000000             0.0000000 #> GZMB                  0.000000             0.1583313             0.0000000 #> TSC2                  0.000000             0.0000000             0.4399346 #>          X23_Y-80..Endothelial X22_Y-81..Endothelial X22_Y-82..Endothelial #> PDK4                 0.8004622             0.8762202             0.4812917 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.0000000             0.2145034 #> GZMB                 0.4520800             0.2009494             0.0000000 #> TSC2                 0.0000000             0.4460518             0.0000000 #>          X23_Y-83..Endothelial X22_Y-83..Endothelial X21_Y-83..Endothelial #> PDK4                         0             1.0521706             0.6813597 #> TNFRSF17                     0             0.0000000             0.0000000 #> ICAM3                        0             0.0000000             0.0000000 #> FAP                          0             0.5326333             0.3120049 #> GZMB                         0             0.0000000             0.0000000 #> TSC2                         0             0.0000000             0.0000000 #>          X23_Y-84..Endothelial X22_Y-84..Endothelial X21_Y-84..Endothelial #> PDK4                 0.0000000             0.2302635                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.4625072             0.2312536                     0 #> GZMB                 0.3941680             0.1970840                     0 #> TSC2                 0.0000000             0.0000000                     0 #>          X21_Y-85..Endothelial X22_Y-85..Endothelial X43_Y-64..Endothelial #> PDK4                 0.3248682             0.7456687             0.6975768 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.0000000             0.6550281 #> GZMB                 0.3248682             0.2526753             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X46_Y-64..Endothelial X44_Y-64..Endothelial X45_Y-64..Endothelial #> PDK4                 0.8668459                     0             0.2376547 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.4615634                     0             0.0000000 #> GZMB                 0.0000000                     0             0.1843320 #> TSC2                 0.0000000                     0             0.0000000 #>          X43_Y-65..Endothelial X46_Y-65..Endothelial X45_Y-65..Endothelial #> PDK4                 1.0375722             0.7324827             0.4625834 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.5954801             0.6006698             0.0000000 #> GZMB                 0.0000000             0.1341331             0.1843320 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X44_Y-65..Endothelial X48_Y-65..Endothelial X45_Y-66..Endothelial #> PDK4                 0.7480289              1.025056             0.9554066 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.0000000              0.884390             0.0000000 #> GZMB                 0.0000000              0.000000             0.0000000 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X46_Y-66..Endothelial X43_Y-66..Endothelial X48_Y-66..Endothelial #> PDK4                 0.7144360              1.283108             0.9111610 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.3868236              0.000000             0.7861244 #> GZMB                 0.1946694              0.000000             0.0000000 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X47_Y-66..Endothelial X46_Y-67..Endothelial X47_Y-67..Endothelial #> PDK4                 0.3754557             1.3212629             0.5833980 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.2065268             0.1808583             0.0000000 #> GZMB                 0.2737308             0.1946694             0.0000000 #> TSC2                 0.0000000             0.1455939             0.2370883 #>          X45_Y-67..Endothelial X52_Y-64..Endothelial X53_Y-64..Endothelial #> PDK4                 0.9955345             1.1374298             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.7234920             0.5245398             0.7868097 #> GZMB                 0.9929658             0.6296916             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X49_Y-64..Endothelial X52_Y-65..Endothelial X49_Y-65..Endothelial #> PDK4                 0.6432827             0.8530724                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.0000000             0.3934048                     0 #> GZMB                 0.0000000             0.4722687                     0 #> TSC2                 0.4181146             0.0000000                     0 #>          X54_Y-65..Endothelial X55_Y-65..Endothelial X53_Y-65..Endothelial #> PDK4                 0.5188800             1.1374856             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.4440548             0.3947154             0.6294477 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.4543701             0.4038845             0.0000000 #>          X51_Y-66..Endothelial X52_Y-66..Endothelial X52_Y-67..Endothelial #> PDK4                 0.7612854              0.752717             0.6021736 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.8421797              0.000000             0.0000000 #> GZMB                 0.0000000              0.000000             0.0000000 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X54_Y-67..Endothelial X39_Y-79..Endothelial X42_Y-79..Endothelial #> PDK4                 0.0000000             1.9588664              1.806109 #> TNFRSF17             0.0000000             0.0000000              0.000000 #> ICAM3                0.0000000             0.0000000              0.000000 #> FAP                  0.7815246             0.4471919              0.000000 #> GZMB                 0.0000000             0.0000000              0.000000 #> TSC2                 0.0000000             0.0000000              0.000000 #>          X37_Y-79..Endothelial X38_Y-79..Endothelial X37_Y-80..Endothelial #> PDK4                  2.569343                     0              1.534851 #> TNFRSF17              0.000000                     0              0.000000 #> ICAM3                 0.000000                     0              0.000000 #> FAP                   4.539500                     0              1.513167 #> GZMB                  0.000000                     0              0.000000 #> TSC2                  0.000000                     0              0.000000 #>          X42_Y-80..Endothelial X41_Y-80..Endothelial X37_Y-81..Endothelial #> PDK4                         0                     0             0.5553547 #> TNFRSF17                     0                     0             0.0000000 #> ICAM3                        0                     0             0.0000000 #> FAP                          0                     0             0.1856786 #> GZMB                         0                     0             0.0000000 #> TSC2                         0                     0             0.0000000 #>          X41_Y-81..Endothelial X37_Y-82..Endothelial X41_Y-82..Endothelial #> PDK4                 1.2114232             1.2754509             1.1961703 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.4697061             0.6165513             0.5535088 #> GZMB                 0.0000000             0.3070563             0.0000000 #> TSC2                 0.2488836             0.0000000             0.0000000 #>          X37_Y-83..Endothelial X41_Y-83..Endothelial X38_Y-83..Endothelial #> PDK4                 1.0091046             0.3190755             2.0920123 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.1414354             0.0000000             0.0000000 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.1685195             0.0000000             0.6740781 #>          X36_Y-84..Endothelial X37_Y-84..Endothelial X38_Y-84..Endothelial #> PDK4                 1.1049096             1.5571309             2.5171006 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.4531468             0.6473422 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.3834037             0.2396273             0.0000000 #>          X39_Y-84..Endothelial X37_Y-85..Endothelial X39_Y-85..Endothelial #> PDK4                  2.212341             1.1918944              2.212341 #> TNFRSF17              0.000000             0.0000000              0.000000 #> ICAM3                 0.000000             0.0000000              0.000000 #> FAP                   1.159644             0.0000000              1.159644 #> GZMB                  0.000000             0.0000000              0.000000 #> TSC2                  0.000000             0.3485488              0.000000 #>          X46_Y-72..Endothelial X47_Y-73..Endothelial X43_Y-74..Endothelial #> PDK4                 0.2278723                     0                     0 #> TNFRSF17             0.0000000                     0                     0 #> ICAM3                0.0000000                     0                     0 #> FAP                  0.1819280                     0                     0 #> GZMB                 0.1557906                     0                     0 #> TSC2                 0.1540726                     0                     0 #>          X46_Y-75..Endothelial X42_Y-76..Endothelial X45_Y-76..Endothelial #> PDK4                         0              1.611570             1.7989473 #> TNFRSF17                     0              0.000000             0.0000000 #> ICAM3                        0              0.000000             0.0000000 #> FAP                          0              1.024427             0.8439578 #> GZMB                         0              0.000000             0.0000000 #> TSC2                         0              0.000000             0.0000000 #>          X46_Y-76..Endothelial X45_Y-77..Endothelial X44_Y-77..Endothelial #> PDK4                 0.5686649             2.2888905             0.2838139 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.2230008             0.3609725 #> GZMB                 0.0000000             0.1755857             0.0000000 #> TSC2                 0.0000000             0.0000000             0.2308726 #>          X46_Y-77..Endothelial X47_Y-77..Endothelial X44_Y-78..Endothelial #> PDK4                 1.7884013                     0             0.4241317 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.1734451                     0             0.0000000 #> GZMB                 0.1365667                     0             0.0000000 #> TSC2                 0.0000000                     0             0.0000000 #>          X46_Y-78..Endothelial X45_Y-78..Endothelial X45_Y-79..Endothelial #> PDK4                 0.9057411             0.5318199             0.2625966 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.4670385             0.4687512 #> GZMB                 0.0000000             0.5350707             0.3302251 #> TSC2                 0.0000000             0.0000000             0.3132703 #>          X44_Y-79..Endothelial X46_Y-73..Endothelial X47_Y-75..Endothelial #> PDK4                 0.5360161             0.0000000                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.2083403             0.1930487                     0 #> GZMB                 0.2425889             0.1557906                     0 #> TSC2                 0.0000000             0.1540726                     0 #>          X47_Y-78..Endothelial X46_Y-79..Endothelial X75_Y-80..Endothelial #> PDK4                  0.000000                     0              0.000000 #> TNFRSF17              0.000000                     0              0.000000 #> ICAM3                 0.000000                     0              0.000000 #> FAP                   3.579154                     0              0.000000 #> GZMB                  0.000000                     0              0.000000 #> TSC2                  0.000000                     0              1.302541 #>          X79_Y-80..Endothelial X77_Y-80..Endothelial X78_Y-80..Endothelial #> PDK4                 0.6724577                     0             0.6724577 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.0000000                     0             0.0000000 #> GZMB                 0.0000000                     0             0.0000000 #> TSC2                 0.0000000                     0             0.0000000 #>          X73_Y-80..Endothelial X74_Y-80..Endothelial X75_Y-81..Endothelial #> PDK4                         0             0.8990608             0.9165616 #> TNFRSF17                     0             0.0000000             0.0000000 #> ICAM3                        0             0.0000000             0.0000000 #> FAP                          0             0.0000000             0.0000000 #> GZMB                         0             0.0000000             0.0000000 #> TSC2                         0             0.0000000             0.4341803 #>          X73_Y-81..Endothelial X75_Y-82..Endothelial X78_Y-82..Endothelial #> PDK4                         0             0.8171265              0.000000 #> TNFRSF17                     0             0.0000000              0.000000 #> ICAM3                        0             0.0000000              0.000000 #> FAP                          0             0.0000000              0.758152 #> GZMB                         0             1.6963892              0.000000 #> TSC2                         0             0.0000000              0.000000 #>          X73_Y-82..Endothelial X78_Y-84..Endothelial X75_Y-79..Endothelial #> PDK4                         0             0.9722751              1.637883 #> TNFRSF17                     0             0.0000000              0.000000 #> ICAM3                        0             0.0000000              0.000000 #> FAP                          0             0.0000000              0.000000 #> GZMB                         0             0.0000000              0.000000 #> TSC2                         0             0.0000000              0.000000 #>          X77_Y-81..Endothelial X77_Y-82..Endothelial X79_Y-82..Endothelial #> PDK4                         0                     0              0.000000 #> TNFRSF17                     0                     0              0.000000 #> ICAM3                        0                     0              0.000000 #> FAP                          0                     0              0.758152 #> GZMB                         0                     0              0.000000 #> TSC2                         0                     0              0.000000 #>          X78_Y-67..Endothelial X74_Y-67..Endothelial X74_Y-68..Endothelial #> PDK4                 0.0000000             1.2846714             0.4514337 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.5084773             0.0000000             0.0000000 #> GZMB                 0.3612125             0.9541226             0.4240545 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X78_Y-68..Endothelial X77_Y-68..Endothelial X77_Y-69..Endothelial #> PDK4                 0.4741097              0.000000             2.4542074 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.8044795              1.104608             0.9840804 #> GZMB                 0.0000000              0.000000             0.0000000 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X73_Y-69..Endothelial X73_Y-70..Endothelial X76_Y-70..Endothelial #> PDK4                 0.9455837              1.891167              0.504238 #> TNFRSF17             0.0000000              0.000000              0.000000 #> ICAM3                0.0000000              0.000000              0.000000 #> FAP                  1.1279623              0.000000              0.000000 #> GZMB                 0.0000000              0.000000              0.000000 #> TSC2                 0.0000000              0.000000              0.000000 #>          X75_Y-70..Endothelial X77_Y-70..Endothelial X76_Y-71..Endothelial #> PDK4                         0             0.7059333              1.764833 #> TNFRSF17                     0             0.0000000              0.000000 #> ICAM3                        0             0.0000000              0.000000 #> FAP                          0             0.0000000              0.000000 #> GZMB                         0             0.0000000              0.000000 #> TSC2                         0             0.0000000              0.000000 #>          X77_Y-71..Endothelial X73_Y-71..Endothelial X78_Y-71..Endothelial #> PDK4                         0                     0              1.937366 #> TNFRSF17                     0                     0              0.000000 #> ICAM3                        0                     0              0.000000 #> FAP                          0                     0              0.000000 #> GZMB                         0                     0              0.000000 #> TSC2                         0                     0              0.000000 #>          X78_Y-72..Endothelial X77_Y-72..Endothelial X75_Y-72..Endothelial #> PDK4                  1.937366             0.7995658                     0 #> TNFRSF17              0.000000             0.0000000                     0 #> ICAM3                 0.000000             0.0000000                     0 #> FAP                   0.000000             0.0000000                     0 #> GZMB                  0.000000             0.0000000                     0 #> TSC2                  0.000000             0.0000000                     0 #>          X76_Y-69..Endothelial X74_Y-72..Endothelial X56_Y-67..Endothelial #> PDK4                         0              2.323947             0.0000000 #> TNFRSF17                     0              0.000000             0.0000000 #> ICAM3                        0              0.000000             0.0000000 #> FAP                          0              1.096645             0.0000000 #> GZMB                         0              0.000000             0.3598959 #> TSC2                         0              0.000000             0.0000000 #>          X57_Y-67..Endothelial X59_Y-67..Endothelial X59_Y-68..Endothelial #> PDK4                 0.0000000              3.627803              1.209268 #> TNFRSF17             0.0000000              0.000000              0.000000 #> ICAM3                0.0000000              0.000000              0.000000 #> FAP                  0.0000000              0.000000              1.178706 #> GZMB                 0.4627233              0.000000              0.000000 #> TSC2                 0.0000000              0.000000              0.000000 #>          X60_Y-68..Endothelial X61_Y-68..Endothelial X58_Y-68..Endothelial #> PDK4                  0.000000              0.000000              0.000000 #> TNFRSF17              0.000000              0.000000              0.000000 #> ICAM3                 0.000000              0.000000              0.000000 #> FAP                   1.792769              4.548155              3.729311 #> GZMB                  0.000000              0.000000              0.000000 #> TSC2                  0.000000              0.000000              0.000000 #>          X60_Y-71..Endothelial X61_Y-71..Endothelial X59_Y-71..Endothelial #> PDK4                 0.9403977             0.7523182             0.7877239 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.9169646             0.7335717             0.3810179 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.4050890 #>          X59_Y-72..Endothelial X58_Y-72..Endothelial X60_Y-72..Endothelial #> PDK4                 0.2433096             0.2270890             0.7877239 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.3363243             0.3139026             0.3810179 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.4050890 #>          X57_Y-72..Endothelial X57_Y-66..Endothelial X58_Y-71..Endothelial #> PDK4                 0.8220544                     0                     0 #> TNFRSF17             0.0000000                     0                     0 #> ICAM3                0.0000000                     0                     0 #> FAP                  0.8220544                     0                     0 #> GZMB                 0.4217487                     0                     0 #> TSC2                 0.0000000                     0                     0 #>          X44_Y-80..Endothelial X45_Y-80..Endothelial X46_Y-80..Endothelial #> PDK4                 0.7767131                     0              0.000000 #> TNFRSF17             0.0000000                     0              0.000000 #> ICAM3                0.0000000                     0              0.000000 #> FAP                  0.0000000                     0              4.248003 #> GZMB                 0.4122471                     0              0.000000 #> TSC2                 0.0000000                     0              0.000000 #>          X44_Y-81..Endothelial X43_Y-81..Endothelial X46_Y-81..Endothelial #> PDK4                 0.6665598             0.4512738             2.4226966 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.4748495             0.9928064 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X43_Y-82..Endothelial X46_Y-82..Endothelial X43_Y-83..Endothelial #> PDK4                 1.0453823              3.452557             0.7626061 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.7268276              0.000000             0.4043413 #> GZMB                 0.3773529              0.000000             0.4779803 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X42_Y-83..Endothelial X45_Y-83..Endothelial X42_Y-84..Endothelial #> PDK4                  0.000000                     0             0.7668495 #> TNFRSF17              0.000000                     0             0.0000000 #> ICAM3                 0.000000                     0             0.0000000 #> FAP                   1.849044                     0             0.1661797 #> GZMB                  0.000000                     0             0.2560750 #> TSC2                  0.000000                     0             0.0000000 #>          X45_Y-84..Endothelial X43_Y-84..Endothelial X43_Y-85..Endothelial #> PDK4                         0             0.7668495             0.8332759 #> TNFRSF17                     0             0.0000000             0.0000000 #> ICAM3                        0             0.0000000             0.0000000 #> FAP                          0             0.1661797             0.2721868 #> GZMB                         0             0.2560750             0.0000000 #> TSC2                         0             0.0000000             0.0000000 #>          X48_Y-79..Endothelial X47_Y-80..Endothelial X48_Y-80..Endothelial #> PDK4                         0              1.356178             0.8137071 #> TNFRSF17                     0              0.000000             0.0000000 #> ICAM3                        0              0.000000             0.0000000 #> FAP                          0              1.416001             0.0000000 #> GZMB                         0              0.000000             0.0000000 #> TSC2                         0              0.000000             0.0000000 #>          X43_Y-80..Endothelial X47_Y-81..Endothelial X44_Y-85..Endothelial #> PDK4                 0.8680911               4.15104             1.7659767 #> TNFRSF17             0.0000000               0.00000             0.0000000 #> ICAM3                0.0000000               0.00000             0.0000000 #> FAP                  0.0000000               0.00000             0.3747638 #> GZMB                 0.4607468               0.00000             0.9412695 #> TSC2                 0.0000000               0.00000             0.0000000 #>          X49_Y-91..Endothelial X50_Y-91..Endothelial X53_Y-91..Endothelial #> PDK4                  3.246155             1.8168812             0.0000000 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             0.6971418             0.5997176 #> GZMB                  0.000000             0.0000000             0.3164890 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X54_Y-91..Endothelial X51_Y-92..Endothelial X52_Y-92..Endothelial #> PDK4                 1.0224777             0.0000000                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.6939495             0.7482577                     0 #> GZMB                 0.0000000             0.0000000                     0 #> TSC2                 0.0000000             0.0000000                     0 #>          X53_Y-93..Endothelial X52_Y-93..Endothelial X51_Y-93..Endothelial #> PDK4                  1.812631                     0              1.431806 #> TNFRSF17              0.000000                     0              0.000000 #> ICAM3                 0.000000                     0              0.000000 #> FAP                   0.000000                     0              0.000000 #> GZMB                  0.000000                     0              0.000000 #> TSC2                  0.000000                     0              0.000000 #>          X49_Y-94..Endothelial X50_Y-94..Endothelial X53_Y-94..Endothelial #> PDK4                 1.7078328              1.060582              1.625456 #> TNFRSF17             0.0000000              0.000000              0.000000 #> ICAM3                0.0000000              0.000000              0.000000 #> FAP                  0.6563945              0.746119              1.625456 #> GZMB                 0.0000000              0.000000              0.000000 #> TSC2                 0.0000000              0.000000              0.000000 #>          X48_Y-94..Endothelial X51_Y-94..Endothelial X51_Y-95..Endothelial #> PDK4                 1.4613203             0.7954477             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.9161118             0.0000000             0.0000000 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.4790215             0.8622388 #>          X50_Y-96..Endothelial X48_Y-96..Endothelial X49_Y-96..Endothelial #> PDK4                         0              1.112724              1.112724 #> TNFRSF17                     0              0.000000              0.000000 #> ICAM3                        0              0.000000              0.000000 #> FAP                          0              0.000000              0.000000 #> GZMB                         0              1.112724              1.112724 #> TSC2                         0              0.000000              0.000000 #>          X54_Y-96..Endothelial X53_Y-97..Endothelial X54_Y-97..Endothelial #> PDK4                         0                     0                     0 #> TNFRSF17                     0                     0                     0 #> ICAM3                        0                     0                     0 #> FAP                          0                     0                     0 #> GZMB                         0                     0                     0 #> TSC2                         0                     0                     0 #>          X53_Y-92..Endothelial X71_Y-81..Endothelial X68_Y-81..Endothelial #> PDK4                  1.450105              1.154826             0.6297731 #> TNFRSF17              0.000000              0.000000             0.0000000 #> ICAM3                 0.000000              0.000000             0.0000000 #> FAP                   0.000000              0.000000             0.7093338 #> GZMB                  0.000000              0.000000             0.4289972 #> TSC2                  0.000000              0.000000             0.3886734 #>          X67_Y-82..Endothelial X67_Y-83..Endothelial X70_Y-84..Endothelial #> PDK4                  1.961004             0.9056173                     0 #> TNFRSF17              0.000000             0.0000000                     0 #> ICAM3                 0.000000             0.0000000                     0 #> FAP                   0.759325             0.0000000                     0 #> GZMB                  0.000000             0.9264497                     0 #> TSC2                  0.000000             0.0000000                     0 #>          X67_Y-84..Endothelial X68_Y-84..Endothelial X72_Y-84..Endothelial #> PDK4                  0.000000             0.8641793                     0 #> TNFRSF17              0.000000             0.0000000                     0 #> ICAM3                 0.000000             0.0000000                     0 #> FAP                   0.000000             0.4120760                     0 #> GZMB                  1.498467             1.2410277                     0 #> TSC2                  0.000000             0.0000000                     0 #>          X72_Y-85..Endothelial X69_Y-85..Endothelial X68_Y-85..Endothelial #> PDK4                  1.323351              1.022033                     0 #> TNFRSF17              0.000000              0.000000                     0 #> ICAM3                 0.000000              0.000000                     0 #> FAP                   0.000000              0.000000                     0 #> GZMB                  0.000000              0.000000                     0 #> TSC2                  0.000000              0.000000                     0 #>          X67_Y-81..Endothelial X69_Y-84..Endothelial X71_Y-85..Endothelial #> PDK4                 0.6297731             1.3163354             0.8822341 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.7093338             0.3433967             0.5653910 #> GZMB                 0.4289972             0.7186450             0.5653910 #> TSC2                 0.3886734             0.0000000             0.0000000 #>          X67_Y-85..Endothelial X51_Y-67..Endothelial X51_Y-68..Endothelial #> PDK4                         0             0.3690301                     0 #> TNFRSF17                     0             0.0000000                     0 #> ICAM3                        0             0.0000000                     0 #> FAP                          0             0.3690301                     0 #> GZMB                         0             0.0000000                     0 #> TSC2                         0             0.0000000                     0 #>          X50_Y-68..Endothelial X52_Y-68..Endothelial X49_Y-68..Endothelial #> PDK4                         0             0.6540389             1.0765494 #> TNFRSF17                     0             0.0000000             0.0000000 #> ICAM3                        0             0.0000000             0.0000000 #> FAP                          0             0.0000000             0.0000000 #> GZMB                         0             0.0000000             0.4961083 #> TSC2                         0             0.0000000             0.0000000 #>          X52_Y-69..Endothelial X50_Y-69..Endothelial X49_Y-69..Endothelial #> PDK4                  3.270194             0.7414604             0.8295212 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             0.0000000             0.3720026 #> GZMB                  0.000000             0.0000000             0.2480542 #> TSC2                  0.000000             0.0000000             0.2996869 #>          X49_Y-70..Endothelial X51_Y-70..Endothelial X48_Y-70..Endothelial #> PDK4                 0.0000000                     0             0.6158943 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.8928064                     0             0.0000000 #> GZMB                 0.0000000                     0             0.4233511 #> TSC2                 0.7192486                     0             0.0000000 #>          X53_Y-70..Endothelial X48_Y-71..Endothelial X53_Y-71..Endothelial #> PDK4                 0.4254884             0.0000000             0.4254884 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.5350449             0.0000000 #> GZMB                 0.0000000             0.4838298             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X53_Y-72..Endothelial X52_Y-72..Endothelial X50_Y-67..Endothelial #> PDK4                  2.855339              1.070752             0.4920402 #> TNFRSF17              0.000000              0.000000             0.0000000 #> ICAM3                 0.000000              0.000000             0.0000000 #> FAP                   0.000000              0.000000             0.4920402 #> GZMB                  1.396223              1.084268             0.0000000 #> TSC2                  0.000000              0.000000             0.0000000 #>          X61_Y-64..Endothelial X64_Y-64..Endothelial X65_Y-64..Endothelial #> PDK4                         0                     0             0.6771505 #> TNFRSF17                     0                     0             0.0000000 #> ICAM3                        0                     0             0.0000000 #> FAP                          0                     0             1.2550956 #> GZMB                         0                     0             0.0000000 #> TSC2                         0                     0             0.0000000 #>          X65_Y-65..Endothelial X66_Y-65..Endothelial X64_Y-65..Endothelial #> PDK4                 0.4062903             0.0000000                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  1.1492270             0.3601542                     0 #> GZMB                 0.0000000             0.0000000                     0 #> TSC2                 0.0000000             0.0000000                     0 #>          X67_Y-65..Endothelial X64_Y-66..Endothelial X67_Y-66..Endothelial #> PDK4                 0.4168962              1.479724             0.3527584 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.4147386              0.000000             0.3509326 #> GZMB                 0.0000000              0.000000             0.0000000 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X56_Y-80..Endothelial X59_Y-80..Endothelial X58_Y-80..Endothelial #> PDK4                    0.0000             0.1890120                     0 #> TNFRSF17                0.0000             0.0000000                     0 #> ICAM3                   0.0000             0.0000000                     0 #> FAP                     0.0000             0.3324506                     0 #> GZMB                    1.3209             0.0000000                     0 #> TSC2                    0.0000             0.0000000                     0 #>          X55_Y-80..Endothelial X60_Y-80..Endothelial X56_Y-81..Endothelial #> PDK4                  0.000000             0.2700171              1.541719 #> TNFRSF17              0.000000             0.0000000              0.000000 #> ICAM3                 0.000000             0.0000000              0.000000 #> FAP                   1.164986             0.7863926              0.000000 #> GZMB                  0.000000             0.0000000              0.000000 #> TSC2                  0.000000             0.0000000              0.000000 #>          X60_Y-81..Endothelial X54_Y-81..Endothelial X57_Y-82..Endothelial #> PDK4                  0.472530             0.0000000             1.1801968 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   1.376187             0.0000000             0.0000000 #> GZMB                  0.000000             0.8834118             0.5489903 #> TSC2                  0.000000             0.6981683             0.0000000 #>          X56_Y-82..Endothelial X57_Y-83..Endothelial X58_Y-83..Endothelial #> PDK4                 1.9031917             1.3500076             0.8267464 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.0000000             0.0000000 #> GZMB                 0.9607331             0.4269925             0.0000000 #> TSC2                 0.0000000             0.0000000             0.3523260 #>          X59_Y-84..Endothelial X57_Y-84..Endothelial X60_Y-84..Endothelial #> PDK4                 0.0000000                     0             0.0000000 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.7272242                     0             0.6233351 #> GZMB                 0.0000000                     0             0.4166893 #> TSC2                 0.0000000                     0             0.0000000 #>          X59_Y-81..Endothelial X60_Y-85..Endothelial X61_Y-85..Endothelial #> PDK4                  0.000000             0.0000000             0.9032628 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   2.348855             0.0000000             0.0000000 #> GZMB                  0.000000             0.4861375             0.0000000 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X63_Y-81..Endothelial X61_Y-83..Endothelial X64_Y-83..Endothelial #> PDK4                  3.820847              0.000000                     0 #> TNFRSF17              0.000000              0.000000                     0 #> ICAM3                 0.000000              0.000000                     0 #> FAP                   0.000000              0.000000                     0 #> GZMB                  0.000000              4.576296                     0 #> TSC2                  0.000000              0.000000                     0 #>          X63_Y-84..Endothelial X64_Y-84..Endothelial X62_Y-84..Endothelial #> PDK4                  0.000000                     0                     0 #> TNFRSF17              0.000000                     0                     0 #> ICAM3                 0.000000                     0                     0 #> FAP                   3.624244                     0                     0 #> GZMB                  0.000000                     0                     0 #> TSC2                  3.624244                     0                     0 #>          X64_Y-85..Endothelial X63_Y-80..Endothelial X34_Y-91..Endothelial #> PDK4                         0                     0              1.051668 #> TNFRSF17                     0                     0              0.000000 #> ICAM3                        0                     0              0.000000 #> FAP                          0                     0              0.184522 #> GZMB                         0                     0              0.000000 #> TSC2                         0                     0              0.000000 #>          X31_Y-91..Endothelial X34_Y-92..Endothelial X33_Y-92..Endothelial #> PDK4                 0.4096266             1.1016718              0.000000 #> TNFRSF17             0.0000000             0.0000000              0.000000 #> ICAM3                0.0000000             0.0000000              0.000000 #> FAP                  0.0000000             0.2323427              3.717483 #> GZMB                 0.0000000             0.0000000              0.000000 #> TSC2                 0.0000000             0.0000000              0.000000 #>          X31_Y-92..Endothelial X30_Y-92..Endothelial X36_Y-92..Endothelial #> PDK4                         0                     0             1.5295955 #> TNFRSF17                     0                     0             0.0000000 #> ICAM3                        0                     0             0.0000000 #> FAP                          0                     0             0.5820287 #> GZMB                         0                     0             0.0000000 #> TSC2                         0                     0             0.0000000 #>          X35_Y-93..Endothelial X34_Y-93..Endothelial X31_Y-94..Endothelial #> PDK4                 1.3939360              1.101018                     0 #> TNFRSF17             0.0000000              0.000000                     0 #> ICAM3                0.0000000              0.000000                     0 #> FAP                  0.4612267              0.518880                     0 #> GZMB                 0.0000000              0.000000                     0 #> TSC2                 0.0000000              0.000000                     0 #>          X30_Y-94..Endothelial X35_Y-94..Endothelial X34_Y-94..Endothelial #> PDK4                 0.3622782             0.3336533             0.4408072 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.3622782             0.0000000             0.0000000 #> GZMB                 0.0000000             0.2707686             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X35_Y-95..Endothelial X34_Y-95..Endothelial X34_Y-96..Endothelial #> PDK4                 1.0588806             0.8850696             0.8050502 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.6558599             0.3980759 #> GZMB                 0.2527173             0.0000000             0.0000000 #> TSC2                 0.0000000             0.1884917             0.0000000 #>          X35_Y-96..Endothelial X35_Y-97..Endothelial X32_Y-91..Endothelial #> PDK4                 0.9412877             1.3125050                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.6628582             0.9956266                     0 #> GZMB                 0.3079424             0.3341021                     0 #> TSC2                 0.0000000             0.0000000                     0 #>          X35_Y-92..Endothelial X45_Y-85..Endothelial X43_Y-86..Endothelial #> PDK4                 0.9343198             1.7659767             1.2273353 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.3747638             0.0000000 #> GZMB                 0.0000000             0.9412695             0.0000000 #> TSC2                 0.0000000             0.0000000             0.2112441 #>          X44_Y-86..Endothelial X42_Y-86..Endothelial X45_Y-87..Endothelial #> PDK4                  1.925955             0.8095856              0.000000 #> TNFRSF17              0.000000             0.0000000              0.000000 #> ICAM3                 0.000000             0.0000000              0.000000 #> FAP                   0.000000             0.0000000              0.000000 #> GZMB                  0.000000             0.4188705              0.000000 #> TSC2                  0.000000             0.4459597              1.538374 #>          X43_Y-87..Endothelial X42_Y-87..Endothelial X46_Y-87..Endothelial #> PDK4                 0.6131804             0.7135307             0.9210538 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.0000000             0.0000000 #> GZMB                 0.0000000             0.3769834             0.9210538 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X48_Y-88..Endothelial X43_Y-88..Endothelial X44_Y-88..Endothelial #> PDK4                  0.000000              0.792432             0.0000000 #> TNFRSF17              0.000000              0.000000             0.0000000 #> ICAM3                 0.000000              0.000000             0.0000000 #> FAP                   0.000000              0.340352             0.3886734 #> GZMB                  0.000000              0.000000             0.0000000 #> TSC2                  1.262179              0.000000             0.0000000 #>          X45_Y-88..Endothelial X42_Y-88..Endothelial X47_Y-88..Endothelial #> PDK4                         0             0.3094109              0.000000 #> TNFRSF17                     0             0.0000000              0.000000 #> ICAM3                        0             0.0000000              0.000000 #> FAP                          0             0.3094109              0.000000 #> GZMB                         0             0.0000000              1.085163 #> TSC2                         0             0.0000000              0.000000 #>          X44_Y-89..Endothelial X42_Y-89..Endothelial X45_Y-89..Endothelial #> PDK4                 0.4640191             0.3971968              0.000000 #> TNFRSF17             0.0000000             0.0000000              0.000000 #> ICAM3                0.0000000             0.0000000              0.000000 #> FAP                  0.3498060             0.0000000              0.000000 #> GZMB                 0.0000000             0.0000000              1.019963 #> TSC2                 0.0000000             0.0000000              0.000000 #>          X48_Y-89..Endothelial X46_Y-89..Endothelial X43_Y-89..Endothelial #> PDK4                 0.0000000             0.0000000             0.6514805 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.4691772             0.0000000 #> GZMB                 0.8681304             0.0000000             0.0000000 #> TSC2                 0.0000000             0.4134331             0.0000000 #>          X47_Y-89..Endothelial X46_Y-90..Endothelial X47_Y-90..Endothelial #> PDK4                         0             0.0000000             0.2481084 #> TNFRSF17                     0             0.0000000             0.0000000 #> ICAM3                        0             0.0000000             0.0000000 #> FAP                          0             0.1876709             0.0000000 #> GZMB                         0             0.1286556             0.7217158 #> TSC2                         0             0.1653732             0.1982097 #>          X48_Y-90..Endothelial X43_Y-90..Endothelial X45_Y-90..Endothelial #> PDK4                 0.3162500             0.5427514             0.1979739 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.5681410             0.5386514 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.2897126             0.0000000             0.0000000 #>          X46_Y-91..Endothelial X47_Y-91..Endothelial X42_Y-85..Endothelial #> PDK4                  0.000000              1.487489             1.3767908 #> TNFRSF17              0.000000              0.000000             0.0000000 #> ICAM3                 0.000000              0.000000             0.0000000 #> FAP                   1.330841              0.000000             0.0000000 #> GZMB                  0.000000              0.000000             0.3414334 #> TSC2                  0.000000              0.000000             0.0000000 #>          X48_Y-86..Endothelial X46_Y-88..Endothelial X53_Y-79..Endothelial #> PDK4                  3.532886                     0              2.787856 #> TNFRSF17              0.000000                     0              0.000000 #> ICAM3                 0.000000                     0              0.000000 #> FAP                   0.000000                     0              0.000000 #> GZMB                  0.000000                     0              0.000000 #> TSC2                  0.000000                     0              0.000000 #>          X51_Y-79..Endothelial X49_Y-80..Endothelial X54_Y-80..Endothelial #> PDK4                         0              1.090686             0.3592662 #> TNFRSF17                     0              0.000000             0.0000000 #> ICAM3                        0              0.000000             0.0000000 #> FAP                          0              0.000000             0.0000000 #> GZMB                         0              0.000000             0.0000000 #> TSC2                         0              0.000000             0.7978480 #>          X50_Y-80..Endothelial X53_Y-80..Endothelial X51_Y-80..Endothelial #> PDK4                 0.0000000             0.0000000                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.4347128             0.0000000                     0 #> GZMB                 0.0000000             0.5251932                     0 #> TSC2                 0.0000000             0.0000000                     0 #>          X50_Y-81..Endothelial X51_Y-81..Endothelial X50_Y-82..Endothelial #> PDK4                 0.0000000              0.000000             0.2230008 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.3580660              0.000000             0.3069137 #> GZMB                 0.6501403              1.106986             0.3371065 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X53_Y-82..Endothelial X54_Y-82..Endothelial X51_Y-83..Endothelial #> PDK4                         0                     0                     0 #> TNFRSF17                     0                     0                     0 #> ICAM3                        0                     0                     0 #> FAP                          0                     0                     0 #> GZMB                         0                     0                     0 #> TSC2                         0                     0                     0 #>          X54_Y-83..Endothelial X52_Y-84..Endothelial X51_Y-85..Endothelial #> PDK4                         0                     0             0.0000000 #> TNFRSF17                     0                     0             0.0000000 #> ICAM3                        0                     0             0.0000000 #> FAP                          0                     0             0.4742904 #> GZMB                         0                     0             0.3452900 #> TSC2                         0                     0             0.0000000 #>          X49_Y-85..Endothelial X52_Y-85..Endothelial X53_Y-81..Endothelial #> PDK4                         0             0.0000000                     0 #> TNFRSF17                     0             0.0000000                     0 #> ICAM3                        0             0.0000000                     0 #> FAP                          0             0.6098019                     0 #> GZMB                         0             0.0000000                     0 #> TSC2                         0             0.0000000                     0 #>          X70_Y-91..Endothelial X68_Y-91..Endothelial X73_Y-95..Endothelial #> PDK4                 0.3084625             0.3312549             0.8551164 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.2419149             0.0000000             0.0000000 #> GZMB                 0.0000000             0.0000000             0.9461129 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X72_Y-95..Endothelial X72_Y-96..Endothelial X68_Y-96..Endothelial #> PDK4                  1.508544             0.8607933             0.5491457 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             0.0000000             0.5976588 #> GZMB                  0.000000             0.0000000             0.8972003 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X68_Y-97..Endothelial X68_Y-92..Endothelial X72_Y-93..Endothelial #> PDK4                 0.0000000             0.2760458              0.925484 #> TNFRSF17             0.0000000             0.0000000              0.000000 #> ICAM3                0.0000000             0.0000000              0.000000 #> FAP                  0.5122789             0.0000000              0.000000 #> GZMB                 0.0000000             0.0000000              0.000000 #> TSC2                 0.0000000             0.0000000              0.000000 #>          X72_Y-94..Endothelial X76_Y-92..Endothelial X76_Y-93..Endothelial #> PDK4                  1.923483                     0                     0 #> TNFRSF17              0.000000                     0                     0 #> ICAM3                 0.000000                     0                     0 #> FAP                   0.000000                     0                     0 #> GZMB                  0.000000                     0                     0 #> TSC2                  0.000000                     0                     0 #>          X75_Y-93..Endothelial X73_Y-93..Endothelial X73_Y-94..Endothelial #> PDK4                 0.6949454                     0                     0 #> TNFRSF17             0.0000000                     0                     0 #> ICAM3                0.0000000                     0                     0 #> FAP                  0.0000000                     0                     0 #> GZMB                 0.7659193                     0                     0 #> TSC2                 0.0000000                     0                     0 #>          X75_Y-95..Endothelial X74_Y-95..Endothelial X74_Y-96..Endothelial #> PDK4                 0.6667555             0.5417388             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.5535815             0.4497849             0.4348158 #> GZMB                 0.6060354             0.4924038             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X76_Y-96..Endothelial X74_Y-97..Endothelial X43_Y-67..Endothelial #> PDK4                  0.000000              4.476843                     0 #> TNFRSF17              0.000000              0.000000                     0 #> ICAM3                 0.000000              0.000000                     0 #> FAP                   4.485477              0.000000                     0 #> GZMB                  0.000000              0.000000                     0 #> TSC2                  0.000000              0.000000                     0 #>          X46_Y-68..Endothelial X44_Y-68..Endothelial X45_Y-69..Endothelial #> PDK4                 1.4266966                     0             1.4458966 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.2527638                     0             0.0000000 #> GZMB                 0.0000000                     0             0.2096740 #> TSC2                 0.2499935                     0             0.2392914 #>          X45_Y-70..Endothelial X47_Y-71..Endothelial X46_Y-71..Endothelial #> PDK4                 1.9854366             0.0000000             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.0000000             0.3718910 #> GZMB                 0.0000000             0.4402383             0.4167104 #> TSC2                 0.5127672             0.2575351             0.0000000 #>          X47_Y-72..Endothelial X74_Y-65..Endothelial X74_Y-66..Endothelial #> PDK4                 0.3672148              0.000000              0.000000 #> TNFRSF17             0.0000000              0.000000              0.000000 #> ICAM3                0.0000000              0.000000              0.000000 #> FAP                  0.8394848              0.000000              0.000000 #> GZMB                 0.0000000              0.000000              0.000000 #> TSC2                 0.2861501              2.057408              1.028704 #>          X76_Y-66..Endothelial X22_Y-92..Endothelial X23_Y-85..Endothelial #> PDK4                  3.709678                     0             0.5759205 #> TNFRSF17              0.000000                     0             0.0000000 #> ICAM3                 0.000000                     0             0.0000000 #> FAP                   0.000000                     0             0.7046366 #> GZMB                  0.000000                     0             0.7046366 #> TSC2                  0.000000                     0             0.0000000 #>          X25_Y-86..Endothelial X23_Y-86..Endothelial X25_Y-87..Endothelial #> PDK4                 0.7207074             0.8119371             0.3155448 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.8775429             0.4697577             0.0000000 #> GZMB                 0.0000000             0.4697577             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X26_Y-87..Endothelial X28_Y-87..Endothelial X27_Y-88..Endothelial #> PDK4                         0              1.129692             1.1331602 #> TNFRSF17                     0              0.000000             0.0000000 #> ICAM3                        0              0.000000             0.0000000 #> FAP                          0              1.131794             0.4637364 #> GZMB                         0              0.000000             0.5192801 #> TSC2                         0              0.000000             0.0000000 #>          X26_Y-88..Endothelial X25_Y-88..Endothelial X29_Y-88..Endothelial #> PDK4                 0.5741413              1.230147              0.000000 #> TNFRSF17             0.0000000              0.000000              0.000000 #> ICAM3                0.0000000              0.000000              0.000000 #> FAP                  0.5788194              0.000000              1.420565 #> GZMB                 0.0000000              0.000000              0.000000 #> TSC2                 0.0000000              1.230147              0.000000 #>          X26_Y-89..Endothelial X29_Y-89..Endothelial X28_Y-89..Endothelial #> PDK4                  1.723036             0.6762172             0.5071629 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             0.7125970             0.0000000 #> GZMB                  0.000000             0.0000000             0.0000000 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X27_Y-89..Endothelial X27_Y-90..Endothelial X28_Y-90..Endothelial #> PDK4                  1.938415             0.6773617             0.4539591 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             0.0000000             0.3961891 #> GZMB                  0.000000             0.0000000             0.0000000 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X25_Y-91..Endothelial X26_Y-86..Endothelial X24_Y-86..Endothelial #> PDK4                  1.279491             0.7731730             0.5409340 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             0.4340652             0.6335396 #> GZMB                  0.000000             0.0000000             0.0000000 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X28_Y-88..Endothelial X28_Y-91..Endothelial X26_Y-92..Endothelial #> PDK4                 0.5982284             0.0000000             0.6397457 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.7794003             0.5942836             0.0000000 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X33_Y-86..Endothelial X35_Y-86..Endothelial X32_Y-87..Endothelial #> PDK4                   1.20599             0.8132725             0.2806748 #> TNFRSF17               0.00000             0.0000000             0.0000000 #> ICAM3                  0.00000             0.0000000             0.0000000 #> FAP                    0.00000             0.5446317             0.4883605 #> GZMB                   0.00000             0.2301705             0.0000000 #> TSC2                   0.00000             0.2332040             0.0000000 #>          X35_Y-87..Endothelial X36_Y-87..Endothelial X33_Y-87..Endothelial #> PDK4                 1.0370420             0.9600078             0.9647917 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.4084738             0.2494840             0.0000000 #> GZMB                 0.1726278             0.0000000             0.0000000 #> TSC2                 0.1749030             0.0000000             0.0000000 #>          X35_Y-88..Endothelial X36_Y-88..Endothelial X32_Y-88..Endothelial #> PDK4                  1.567349             1.2286771             1.4268899 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             0.4512859             0.4132282 #> GZMB                  0.000000             0.0000000             0.0000000 #> TSC2                  0.000000             0.2191275             0.0000000 #>          X33_Y-89..Endothelial X34_Y-90..Endothelial X32_Y-90..Endothelial #> PDK4                 0.8091677             1.4626801             0.4565729 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.7615363             0.2636029             0.0000000 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X36_Y-90..Endothelial X33_Y-90..Endothelial X33_Y-91..Endothelial #> PDK4                 1.0126203                     0             0.9920182 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.4717726                     0             0.2323427 #> GZMB                 0.0000000                     0             0.0000000 #> TSC2                 0.0000000                     0             0.0000000 #>          X35_Y-91..Endothelial X36_Y-91..Endothelial X32_Y-89..Endothelial #> PDK4                  1.475318              1.774343             2.2413138 #> TNFRSF17              0.000000              0.000000             0.0000000 #> ICAM3                 0.000000              0.000000             0.0000000 #> FAP                   0.000000              0.000000             0.8567283 #> GZMB                  0.000000              0.000000             0.0000000 #> TSC2                  0.000000              0.000000             0.0000000 #>          X34_Y-89..Endothelial X41_Y-86..Endothelial X41_Y-88..Endothelial #> PDK4                  2.430359              2.305913                     0 #> TNFRSF17              0.000000              0.000000                     0 #> ICAM3                 0.000000              0.000000                     0 #> FAP                   0.000000              0.000000                     0 #> GZMB                  0.000000              0.000000                     0 #> TSC2                  0.000000              0.000000                     0 #>          X38_Y-88..Endothelial X41_Y-89..Endothelial X36_Y-89..Endothelial #> PDK4                         0              1.029928              3.158263 #> TNFRSF17                     0              0.000000              0.000000 #> ICAM3                        0              0.000000              0.000000 #> FAP                          0              0.000000              1.173387 #> GZMB                         0              0.000000              0.000000 #> TSC2                         0              0.000000              0.000000 #>          X37_Y-89..Endothelial X38_Y-89..Endothelial X39_Y-89..Endothelial #> PDK4                 2.2463073             1.2407674                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.2707117             0.1741323                     0 #> GZMB                 0.0000000             0.1741323                     0 #> TSC2                 0.0000000             0.0000000                     0 #>          X41_Y-90..Endothelial X37_Y-90..Endothelial X38_Y-90..Endothelial #> PDK4                   1.97208              1.458552             0.6253224 #> TNFRSF17               0.00000              0.000000             0.0000000 #> ICAM3                  0.00000              0.000000             0.0000000 #> FAP                    0.00000              0.000000             0.1774576 #> GZMB                   0.00000              0.000000             0.0000000 #> TSC2                   0.00000              0.000000             0.0000000 #>          X39_Y-91..Endothelial X30_Y-98..Endothelial X35_Y-98..Endothelial #> PDK4                 0.8163341              2.262268             1.0100580 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.0000000              0.000000             0.9757283 #> GZMB                 0.0000000              0.000000             0.4772887 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X35_Y-99..Endothelial X35_Y-100..Endothelial X34_Y-100..Endothelial #> PDK4                 2.6217793              1.4998373              1.5304628 #> TNFRSF17             0.0000000              0.0000000              0.0000000 #> ICAM3                0.0000000              0.0000000              0.0000000 #> FAP                  0.0000000              0.4656839              0.3333234 #> GZMB                 0.3761591              0.0000000              0.0000000 #> TSC2                 0.0000000              0.0000000              0.0000000 #>          X35_Y-101..Endothelial X33_Y-101..Endothelial X30_Y-101..Endothelial #> PDK4                  1.0496164              0.9389332              1.0612597 #> TNFRSF17              0.0000000              0.0000000              0.0000000 #> ICAM3                 0.0000000              0.0000000              0.0000000 #> FAP                   0.5322102              0.2257872              0.2283413 #> GZMB                  0.0000000              0.0000000              0.0000000 #> TSC2                  0.0000000              0.0000000              0.0000000 #>          X31_Y-101..Endothelial X34_Y-101..Endothelial X32_Y-101..Endothelial #> PDK4                  1.5469214              0.3959515                      0 #> TNFRSF17              0.0000000              0.0000000                      0 #> ICAM3                 0.0000000              0.0000000                      0 #> FAP                   0.3978199              0.3920430                      0 #> GZMB                  0.0000000              0.0000000                      0 #> TSC2                  0.0000000              0.0000000                      0 #>          X35_Y-102..Endothelial X32_Y-102..Endothelial X34_Y-102..Endothelial #> PDK4                   0.906726              0.7412148              0.0000000 #> TNFRSF17               0.000000              0.0000000              0.0000000 #> ICAM3                  0.000000              0.0000000              0.0000000 #> FAP                    0.150468              0.1769004              0.3697822 #> GZMB                   0.000000              0.0000000              0.0000000 #> TSC2                   0.000000              0.0000000              0.0000000 #>          X30_Y-102..Endothelial X31_Y-102..Endothelial X33_Y-102..Endothelial #> PDK4                  1.2790002              0.7958576              0.8074671 #> TNFRSF17              0.0000000              0.0000000              0.0000000 #> ICAM3                 0.0000000              0.0000000              0.0000000 #> FAP                   0.2743211              0.3814274              0.1592104 #> GZMB                  0.0000000              0.1796400              0.0000000 #> TSC2                  0.0000000              0.1899630              0.0000000 #>          X29_Y-102..Endothelial X35_Y-103..Endothelial X31_Y-103..Endothelial #> PDK4                  0.7099059              1.6175390              1.3757024 #> TNFRSF17              0.0000000              0.0000000              0.0000000 #> ICAM3                 0.0000000              0.0000000              0.0000000 #> FAP                   0.2463577              0.0000000              0.5325299 #> GZMB                  0.0000000              0.2406760              0.0000000 #> TSC2                  0.0000000              0.2483568              0.0000000 #>          X34_Y-103..Endothelial X30_Y-103..Endothelial X32_Y-103..Endothelial #> PDK4                  0.9727997              1.8693058               1.144242 #> TNFRSF17              0.0000000              0.0000000               0.000000 #> ICAM3                 0.0000000              0.0000000               0.000000 #> FAP                   0.3811256              0.3846049               0.000000 #> GZMB                  0.0000000              0.0000000               0.000000 #> TSC2                  0.1862676              0.0000000               0.000000 #>          X33_Y-103..Endothelial X30_Y-104..Endothelial X34_Y-104..Endothelial #> PDK4                   1.066544              1.5956090              0.3457859 #> TNFRSF17               0.000000              0.0000000              0.0000000 #> ICAM3                  0.000000              0.0000000              0.0000000 #> FAP                    0.000000              0.3095586              0.5178252 #> GZMB                   0.000000              0.0000000              0.0000000 #> TSC2                   0.000000              0.0000000              0.1935062 #>          X35_Y-104..Endothelial X31_Y-104..Endothelial X22_Y-86..Endothelial #> PDK4                  1.6471422              1.1781780             0.5206291 #> TNFRSF17              0.0000000              0.0000000             0.0000000 #> ICAM3                 0.0000000              0.0000000             0.0000000 #> FAP                   0.4093617              0.0000000             0.0000000 #> GZMB                  0.2427329              0.2699047             0.0000000 #> TSC2                  0.0000000              0.0000000             0.0000000 #>          X21_Y-86..Endothelial X22_Y-87..Endothelial X21_Y-91..Endothelial #> PDK4                 0.5206291              2.072317                     0 #> TNFRSF17             0.0000000              0.000000                     0 #> ICAM3                0.0000000              0.000000                     0 #> FAP                  0.0000000              0.000000                     0 #> GZMB                 0.0000000              0.000000                     0 #> TSC2                 0.0000000              0.000000                     0 #>          X22_Y-65..Endothelial X21_Y-65..Endothelial X22_Y-66..Endothelial #> PDK4                 1.0108618             0.8676740              1.401803 #> TNFRSF17             0.0000000             0.0000000              0.000000 #> ICAM3                0.0000000             0.0000000              0.000000 #> FAP                  0.4457561             0.6514897              0.000000 #> GZMB                 0.0000000             0.0000000              0.000000 #> TSC2                 0.0000000             0.0000000              0.000000 #>          X22_Y-64..Endothelial X23_Y-98..Endothelial X22_Y-98..Endothelial #> PDK4                 0.3786538             0.9215440                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.8469366             0.1801583                     0 #> GZMB                 0.0000000             0.0000000                     0 #> TSC2                 0.0000000             0.0000000                     0 #>          X22_Y-99..Endothelial X23_Y-99..Endothelial X24_Y-99..Endothelial #> PDK4                 1.1996715              2.006595             1.3765409 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.5705031              0.196837             0.6278154 #> GZMB                 0.3519396              0.000000             0.0000000 #> TSC2                 0.0000000              0.000000             0.2545412 #>          X22_Y-100..Endothelial X23_Y-100..Endothelial X23_Y-102..Endothelial #> PDK4                  2.0006514              1.7715678               1.537086 #> TNFRSF17              0.0000000              0.0000000               0.000000 #> ICAM3                 0.0000000              0.0000000               0.000000 #> FAP                   0.3250147              0.2761054               0.000000 #> GZMB                  0.0000000              0.0000000               0.000000 #> TSC2                  0.0000000              0.0000000               0.000000 #>          X21_Y-102..Endothelial X22_Y-102..Endothelial X23_Y-103..Endothelial #> PDK4                   1.850968               1.537086               1.384905 #> TNFRSF17               0.000000               0.000000               0.000000 #> ICAM3                  0.000000               0.000000               0.000000 #> FAP                    0.000000               0.000000               0.000000 #> GZMB                   0.000000               0.000000               0.000000 #> TSC2                   0.000000               0.000000               0.000000 #>          X21_Y-99..Endothelial X25_Y-98..Endothelial X27_Y-98..Endothelial #> PDK4                 0.0000000             0.2188409             0.5258986 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.8211924             0.0000000             0.6253808 #> GZMB                 0.8211924             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X29_Y-98..Endothelial X24_Y-100..Endothelial X28_Y-101..Endothelial #> PDK4                  2.262268              2.0732613                1.50293 #> TNFRSF17              0.000000              0.0000000                0.00000 #> ICAM3                 0.000000              0.0000000                0.00000 #> FAP                   0.000000              0.3988189                0.00000 #> GZMB                  0.000000              0.0000000                0.00000 #> TSC2                  0.000000              0.0000000                0.00000 #>          X27_Y-101..Endothelial X29_Y-101..Endothelial X27_Y-102..Endothelial #> PDK4                   1.630202              0.5002990              0.6211478 #> TNFRSF17               0.000000              0.0000000              0.0000000 #> ICAM3                  0.000000              0.0000000              0.0000000 #> FAP                    0.000000              0.1306000              0.3056033 #> GZMB                   0.000000              0.1332536              0.0000000 #> TSC2                   0.000000              0.0000000              0.0000000 #>          X28_Y-102..Endothelial X26_Y-102..Endothelial X25_Y-102..Endothelial #> PDK4                  0.5766403              0.7091657               1.262882 #> TNFRSF17              0.0000000              0.0000000               0.000000 #> ICAM3                 0.0000000              0.0000000               0.000000 #> FAP                   0.2031452              0.2375323               0.000000 #> GZMB                  0.1980848              0.0000000               0.000000 #> TSC2                  0.0000000              0.0000000               1.237857 #>          X28_Y-103..Endothelial X26_Y-103..Endothelial X26_Y-104..Endothelial #> PDK4                  0.3569178              0.7947346                1.45216 #> TNFRSF17              0.0000000              0.0000000                0.00000 #> ICAM3                 0.0000000              0.0000000                0.00000 #> FAP                   0.2359745              0.2137791                0.00000 #> GZMB                  0.0000000              0.0000000                0.00000 #> TSC2                  0.0000000              0.0000000                0.00000 #>          X29_Y-103..Endothelial X24_Y-104..Endothelial X74_Y-104..Endothelial #> PDK4                   2.128942               1.105377               1.533691 #> TNFRSF17               0.000000               0.000000               0.000000 #> ICAM3                  0.000000               0.000000               0.000000 #> FAP                    0.000000               0.000000               0.000000 #> GZMB                   0.000000               0.000000               1.004630 #> TSC2                   0.000000               0.000000               0.000000 #>          X77_Y-104..Endothelial X76_Y-105..Endothelial X77_Y-105..Endothelial #> PDK4                  0.9487501               1.097688              0.9147403 #> TNFRSF17              0.0000000               0.000000              0.0000000 #> ICAM3                 0.0000000               0.000000              0.0000000 #> FAP                   0.0000000               0.000000              0.0000000 #> GZMB                  0.0000000               0.000000              0.0000000 #> TSC2                  0.0000000               0.000000              0.0000000 #>          X76_Y-106..Endothelial X74_Y-105..Endothelial X76_Y-107..Endothelial #> PDK4                  0.0000000               3.067383              0.7343170 #> TNFRSF17              0.0000000               0.000000              0.0000000 #> ICAM3                 0.0000000               0.000000              0.0000000 #> FAP                   0.6858322               0.000000              0.6858322 #> GZMB                  0.0000000               0.000000              0.0000000 #> TSC2                  0.0000000               0.000000              0.0000000 #>          X75_Y-107..Endothelial X65_Y-97..Endothelial X67_Y-98..Endothelial #> PDK4                    1.28397              0.000000                     0 #> TNFRSF17                0.00000              0.000000                     0 #> ICAM3                   0.00000              0.000000                     0 #> FAP                     0.00000              1.088931                     0 #> GZMB                    1.28397              0.000000                     0 #> TSC2                    0.00000              0.000000                     0 #>          X66_Y-98..Endothelial X61_Y-99..Endothelial X62_Y-99..Endothelial #> PDK4                         0              0.000000             0.7574019 #> TNFRSF17                     0              0.000000             0.0000000 #> ICAM3                        0              0.000000             0.0000000 #> FAP                          0              4.333204             0.3750924 #> GZMB                         0              0.000000             0.0000000 #> TSC2                         0              0.000000             0.0000000 #>          X62_Y-100..Endothelial X64_Y-100..Endothelial X63_Y-100..Endothelial #> PDK4                  0.7505041               1.147905              0.7851413 #> TNFRSF17              0.0000000               0.000000              0.0000000 #> ICAM3                 0.0000000               0.000000              0.0000000 #> FAP                   0.2411308               0.000000              0.7610388 #> GZMB                  0.2318682               0.000000              0.3606839 #> TSC2                  0.0000000               0.000000              0.0000000 #>          X66_Y-100..Endothelial X65_Y-101..Endothelial X65_Y-102..Endothelial #> PDK4                          0              1.1598654                      0 #> TNFRSF17                      0              0.0000000                      0 #> ICAM3                         0              0.0000000                      0 #> FAP                           0              0.0000000                      0 #> GZMB                          0              0.3067167                      0 #> TSC2                          0              0.0000000                      0 #>          X66_Y-102..Endothelial X66_Y-103..Endothelial X64_Y-103..Endothelial #> PDK4                  0.9995219                      0                      0 #> TNFRSF17              0.0000000                      0                      0 #> ICAM3                 0.0000000                      0                      0 #> FAP                   0.0000000                      0                      0 #> GZMB                  0.6066330                      0                      0 #> TSC2                  0.0000000                      0                      0 #>          X64_Y-101..Endothelial X67_Y-102..Endothelial X66_Y-104..Endothelial #> PDK4                   1.742543              0.0000000              0.4221172 #> TNFRSF17               0.000000              0.0000000              0.0000000 #> ICAM3                  0.000000              0.0000000              0.0000000 #> FAP                    0.000000              0.4809264              0.0000000 #> GZMB                   0.000000              0.9560357              0.7002576 #> TSC2                   0.000000              0.0000000              0.0000000 #>          X22_Y-107..Endothelial X67_Y-86..Endothelial X68_Y-86..Endothelial #> PDK4                          0                     0                     0 #> TNFRSF17                      0                     0                     0 #> ICAM3                         0                     0                     0 #> FAP                           0                     0                     0 #> GZMB                          0                     0                     0 #> TSC2                          0                     0                     0 #>          X68_Y-87..Endothelial X69_Y-87..Endothelial X67_Y-87..Endothelial #> PDK4                 0.5160341             0.3416151             0.3856785 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.0000000             0.3639847 #> GZMB                 0.3157206             0.0000000             0.0000000 #> TSC2                 0.0000000             0.4038845             0.3639847 #>          X68_Y-88..Endothelial X68_Y-89..Endothelial X67_Y-89..Endothelial #> PDK4                 0.7794684                     0             0.3481473 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.0000000                     0             0.6317782 #> GZMB                 0.9471617                     0             0.0000000 #> TSC2                 0.9476900                     0             0.0000000 #>          X68_Y-90..Endothelial X25_Y-104..Endothelial X28_Y-104..Endothelial #> PDK4                         0               1.036291              1.0468835 #> TNFRSF17                     0               0.000000              0.0000000 #> ICAM3                        0               0.000000              0.0000000 #> FAP                          0               0.000000              0.3371065 #> GZMB                         0               0.000000              0.2401635 #> TSC2                         0               0.000000              0.3064051 #>          X28_Y-105..Endothelial X29_Y-105..Endothelial X25_Y-105..Endothelial #> PDK4                  1.2778628              1.0531984              0.9473931 #> TNFRSF17              0.0000000              0.0000000              0.0000000 #> ICAM3                 0.0000000              0.0000000              0.0000000 #> FAP                   0.2064564              0.3559807              0.0000000 #> GZMB                  0.2586376              0.0000000              0.3358416 #> TSC2                  0.3299747              0.0000000              0.3412198 #>          X26_Y-105..Endothelial X24_Y-105..Endothelial X24_Y-106..Endothelial #> PDK4                  1.5038988              0.7537624              0.5895344 #> TNFRSF17              0.0000000              0.0000000              0.0000000 #> ICAM3                 0.0000000              0.0000000              0.0000000 #> FAP                   0.4365748              0.3492905              0.4640758 #> GZMB                  0.0000000              0.1847129              0.0000000 #> TSC2                  0.4365748              0.1876709              0.0000000 #>          X27_Y-106..Endothelial X26_Y-106..Endothelial X30_Y-106..Endothelial #> PDK4                  1.6508360              0.6194921              0.6697434 #> TNFRSF17              0.0000000              0.0000000              0.0000000 #> ICAM3                 0.0000000              0.0000000              0.0000000 #> FAP                   0.2664608              0.0000000              0.4838945 #> GZMB                  0.0000000              0.6194921              0.1614845 #> TSC2                  0.0000000              0.0000000              0.0000000 #>          X29_Y-106..Endothelial X28_Y-106..Endothelial X26_Y-107..Endothelial #> PDK4                  0.9269665               1.482092              0.3871826 #> TNFRSF17              0.0000000               0.000000              0.0000000 #> ICAM3                 0.0000000               0.000000              0.0000000 #> FAP                   0.1850968               0.000000              0.5293126 #> GZMB                  0.1614845               0.000000              0.3871826 #> TSC2                  0.0000000               0.000000              0.0000000 #>          X30_Y-107..Endothelial X28_Y-107..Endothelial X27_Y-107..Endothelial #> PDK4                  0.5072372              0.9494827              0.8705592 #> TNFRSF17              0.0000000              0.0000000              0.0000000 #> ICAM3                 0.0000000              0.0000000              0.0000000 #> FAP                   0.2078739              0.0000000              0.0000000 #> GZMB                  0.0000000              0.0000000              0.0000000 #> TSC2                  0.0000000              0.0000000              0.0000000 #>          X30_Y-105..Endothelial X69_Y-102..Endothelial X70_Y-103..Endothelial #> PDK4                  0.6645082                      0                      0 #> TNFRSF17              0.0000000                      0                      0 #> ICAM3                 0.0000000                      0                      0 #> FAP                   0.3365396                      0                      0 #> GZMB                  0.2936083                      0                      0 #> TSC2                  0.0000000                      0                      0 #>          X68_Y-98..Endothelial X70_Y-104..Endothelial X67_Y-104..Endothelial #> PDK4                         0              0.5483225               1.266352 #> TNFRSF17                     0              0.0000000               0.000000 #> ICAM3                        0              0.0000000               0.000000 #> FAP                          0              0.0000000               0.000000 #> GZMB                         0              0.0000000               2.100773 #> TSC2                         0              0.0000000               0.000000 #>          X71_Y-105..Endothelial X70_Y-105..Endothelial X72_Y-105..Endothelial #> PDK4                          0              0.8482456              1.4940079 #> TNFRSF17                      0              0.0000000              0.0000000 #> ICAM3                         0              0.0000000              0.0000000 #> FAP                           0              0.0000000              0.0000000 #> GZMB                          0              0.0000000              0.4334352 #> TSC2                          0              0.0000000              0.4872638 #>          X72_Y-106..Endothelial X70_Y-106..Endothelial X68_Y-106..Endothelial #> PDK4                  0.8923421              0.7068714                      0 #> TNFRSF17              0.0000000              0.0000000                      0 #> ICAM3                 0.0000000              0.0000000                      0 #> FAP                   0.0000000              0.9430810                      0 #> GZMB                  0.0000000              0.0000000                      0 #> TSC2                  0.4331234              0.0000000                      0 #>          X72_Y-107..Endothelial X71_Y-107..Endothelial X69_Y-107..Endothelial #> PDK4                   1.206899               0.000000                      0 #> TNFRSF17               0.000000               0.000000                      0 #> ICAM3                  0.000000               0.000000                      0 #> FAP                    0.000000               4.520800                      0 #> GZMB                   0.000000               3.838474                      0 #> TSC2                   0.000000               0.000000                      0 #>          X70_Y-107..Endothelial X73_Y-107..Endothelial X59_Y-103..Endothelial #> PDK4                   0.000000                      0                      0 #> TNFRSF17               0.000000                      0                      0 #> ICAM3                  0.000000                      0                      0 #> FAP                    2.260400                      0                      0 #> GZMB                   1.919237                      0                      0 #> TSC2                   0.000000                      0                      0 #>          X56_Y-104..Endothelial X59_Y-104..Endothelial X58_Y-104..Endothelial #> PDK4                  0.0000000              0.3882318              0.0000000 #> TNFRSF17              0.0000000              0.0000000              0.0000000 #> ICAM3                 0.0000000              0.0000000              0.0000000 #> FAP                   0.1595378              0.5726165              0.8614058 #> GZMB                  0.0000000              0.5177491              1.1062589 #> TSC2                  0.3584031              0.0000000              0.6011497 #>          X58_Y-105..Endothelial X57_Y-105..Endothelial X56_Y-105..Endothelial #> PDK4                  0.4984146              0.4063066              0.1868640 #> TNFRSF17              0.0000000              0.0000000              0.0000000 #> ICAM3                 0.0000000              0.0000000              0.0000000 #> FAP                   1.2521447              0.1993658              0.1435840 #> GZMB                  0.9679765              0.0000000              0.0000000 #> TSC2                  0.5260060              0.0000000              0.3225628 #>          X55_Y-106..Endothelial X61_Y-106..Endothelial X54_Y-106..Endothelial #> PDK4                  0.6143416                      0              0.4223599 #> TNFRSF17              0.0000000                      0              0.0000000 #> ICAM3                 0.0000000                      0              0.0000000 #> FAP                   0.5635467                      0              0.6159862 #> GZMB                  0.4059497                      0              0.5501480 #> TSC2                  0.0000000                      0              0.0000000 #>          X54_Y-107..Endothelial X57_Y-103..Endothelial X54_Y-104..Endothelial #> PDK4                  1.1576668                      0              0.0000000 #> TNFRSF17              0.0000000                      0              0.0000000 #> ICAM3                 0.0000000                      0              0.0000000 #> FAP                   0.4403962                      0              0.0000000 #> GZMB                  0.9273195                      0              0.6465605 #> TSC2                  0.0000000                      0              0.0000000 #>          X57_Y-104..Endothelial X55_Y-105..Endothelial X64_Y-104..Endothelial #> PDK4                  0.2069407                1.15399              0.4898801 #> TNFRSF17              0.0000000                0.00000              0.0000000 #> ICAM3                 0.0000000                0.00000              0.0000000 #> FAP                   0.1435840                0.00000              0.4898801 #> GZMB                  0.0000000                0.00000              0.0000000 #> TSC2                  0.1776219                0.00000              0.0000000 #>          X65_Y-104..Endothelial X66_Y-106..Endothelial X62_Y-105..Endothelial #> PDK4                    1.71458               0.000000                      0 #> TNFRSF17                0.00000               0.000000                      0 #> ICAM3                   0.00000               0.000000                      0 #> FAP                     1.71458               4.344398                      0 #> GZMB                    0.00000               0.000000                      0 #> TSC2                    0.00000               0.000000                      0 #>          X79_Y-100..Endothelial X53_Y-104..Endothelial X50_Y-104..Endothelial #> PDK4                          0                      0              0.7337304 #> TNFRSF17                      0                      0              0.0000000 #> ICAM3                         0                      0              0.0000000 #> FAP                           0                      0              0.5039680 #> GZMB                          0                      0              0.5039680 #> TSC2                          0                      0              0.0000000 #>          X52_Y-105..Endothelial X54_Y-105..Endothelial X53_Y-105..Endothelial #> PDK4                   0.000000               1.248438               1.872657 #> TNFRSF17               0.000000               0.000000               0.000000 #> ICAM3                  0.000000               0.000000               0.000000 #> FAP                    0.000000               0.000000               0.000000 #> GZMB                   3.440786               0.000000               0.000000 #> TSC2                   0.000000               0.000000               0.000000 #>          X53_Y-106..Endothelial X53_Y-107..Endothelial X33_Y-104..Endothelial #> PDK4                  1.7485848               1.249402              0.6429765 #> TNFRSF17              0.0000000               0.000000              0.0000000 #> ICAM3                 0.0000000               0.000000              0.0000000 #> FAP                   0.6779147               0.000000              0.3027885 #> GZMB                  0.0000000               0.000000              0.0000000 #> TSC2                  0.0000000               0.000000              0.0000000 #>          X32_Y-104..Endothelial X33_Y-105..Endothelial X34_Y-105..Endothelial #> PDK4                  1.6013119              1.1450889              1.5412348 #> TNFRSF17              0.0000000              0.0000000              0.0000000 #> ICAM3                 0.0000000              0.0000000              0.0000000 #> FAP                   0.6621607              0.3307143              0.2335853 #> GZMB                  0.0000000              0.0000000              0.0000000 #> TSC2                  0.0000000              0.0000000              0.0000000 #>          X35_Y-105..Endothelial X32_Y-105..Endothelial X35_Y-106..Endothelial #> PDK4                   2.817623               3.214642              1.0664769 #> TNFRSF17               0.000000               0.000000              0.0000000 #> ICAM3                  0.000000               0.000000              0.0000000 #> FAP                    0.000000               1.612857              0.2269014 #> GZMB                   0.000000               0.000000              0.1884807 #> TSC2                   0.000000               0.000000              0.0000000 #>          X35_Y-107..Endothelial X34_Y-107..Endothelial X33_Y-107..Endothelial #> PDK4                  0.8393564              0.4952121                      0 #> TNFRSF17              0.0000000              0.0000000                      0 #> ICAM3                 0.0000000              0.0000000                      0 #> FAP                   0.4046942              0.4254400                      0 #> GZMB                  0.1919742              0.0000000                      0 #> TSC2                  0.0000000              0.0000000                      0 #>          X34_Y-106..Endothelial X45_Y-104..Endothelial X42_Y-106..Endothelial #> PDK4                  0.9469626               1.653732               3.741288 #> TNFRSF17              0.0000000               0.000000               0.000000 #> ICAM3                 0.0000000               0.000000               0.000000 #> FAP                   0.2618093               1.653732               0.000000 #> GZMB                  0.2174777               0.000000               0.000000 #> TSC2                  0.0000000               1.983383               0.000000 #>          X46_Y-106..Endothelial X43_Y-106..Endothelial X44_Y-106..Endothelial #> PDK4                          0              0.9562075              0.9562075 #> TNFRSF17                      0              0.0000000              0.0000000 #> ICAM3                         0              0.0000000              0.0000000 #> FAP                           0              0.0000000              0.0000000 #> GZMB                          0              0.4404911              0.4404911 #> TSC2                          0              0.5974709              0.5974709 #>          X44_Y-107..Endothelial X46_Y-107..Endothelial X60_Y-99..Endothelial #> PDK4                  1.1155754                      0               1.52802 #> TNFRSF17              0.0000000                      0               0.00000 #> ICAM3                 0.0000000                      0               0.00000 #> FAP                   0.0000000                      0               0.00000 #> GZMB                  0.5139063                      0               0.00000 #> TSC2                  0.6970494                      0               0.00000 #>          X55_Y-99..Endothelial X54_Y-99..Endothelial X59_Y-101..Endothelial #> PDK4                 0.8990608                     0              1.0990235 #> TNFRSF17             0.0000000                     0              0.0000000 #> ICAM3                0.0000000                     0              0.0000000 #> FAP                  0.0000000                     0              0.4765399 #> GZMB                 0.0000000                     0              0.0000000 #> TSC2                 0.0000000                     0              1.5020588 #>          X58_Y-101..Endothelial X55_Y-102..Endothelial X57_Y-102..Endothelial #> PDK4                  1.2821940                      0              0.0000000 #> TNFRSF17              0.0000000                      0              0.0000000 #> ICAM3                 0.0000000                      0              0.0000000 #> FAP                   0.5559632                      0              0.0000000 #> GZMB                  0.0000000                      0              0.0000000 #> TSC2                  1.7524019                      0              0.8711444 #>          X56_Y-102..Endothelial X56_Y-103..Endothelial X39_Y-97..Endothelial #> PDK4                  0.4719490               1.573163             0.9525105 #> TNFRSF17              0.0000000               0.000000             0.0000000 #> ICAM3                 0.0000000               0.000000             0.0000000 #> FAP                   0.0000000               0.000000             0.0000000 #> GZMB                  0.0000000               0.000000             0.0000000 #> TSC2                  0.4355722               0.000000             0.1779523 #>          X37_Y-97..Endothelial X40_Y-97..Endothelial X37_Y-98..Endothelial #> PDK4                 1.3646833             0.4680505             2.7691433 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.4264808             0.0000000             0.9179353 #> GZMB                 0.2260297             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X39_Y-98..Endothelial X40_Y-98..Endothelial X38_Y-98..Endothelial #> PDK4                 0.1956208              1.800019             0.4221011 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.1515643              0.000000             0.5317270 #> GZMB                 0.2450162              0.000000             0.4185410 #> TSC2                 0.1597685              0.000000             0.1597685 #>          X38_Y-99..Endothelial X39_Y-99..Endothelial X40_Y-99..Endothelial #> PDK4                 0.8615243             0.4958189             0.6117898 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.5941652             0.2411473             0.3235595 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X37_Y-99..Endothelial X39_Y-100..Endothelial X38_Y-100..Endothelial #> PDK4                 1.6704177               1.494714              1.0115168 #> TNFRSF17             0.0000000               0.000000              0.0000000 #> ICAM3                0.0000000               0.000000              0.0000000 #> FAP                  0.8176509               0.000000              0.1523215 #> GZMB                 0.0000000               0.000000              0.0000000 #> TSC2                 0.0000000               0.000000              0.0000000 #>          X40_Y-100..Endothelial X42_Y-100..Endothelial X41_Y-100..Endothelial #> PDK4                  0.2831146                      0              0.3451083 #> TNFRSF17              0.0000000                      0              0.0000000 #> ICAM3                 0.0000000                      0              0.0000000 #> FAP                   0.5449065                      0              0.0000000 #> GZMB                  0.0000000                      0              0.1493658 #> TSC2                  0.0000000                      0              0.0000000 #>          X38_Y-101..Endothelial X39_Y-101..Endothelial X41_Y-101..Endothelial #> PDK4                  1.1814993              0.8892527              0.5751805 #> TNFRSF17              0.0000000              0.0000000              0.0000000 #> ICAM3                 0.0000000              0.0000000              0.0000000 #> FAP                   0.6771758              0.5184961              0.0000000 #> GZMB                  0.0000000              0.0000000              0.2489430 #> TSC2                  0.0000000              0.0000000              0.0000000 #>          X42_Y-103..Endothelial X38_Y-97..Endothelial X42_Y-98..Endothelial #> PDK4                   2.094335             0.6391682             0.0000000 #> TNFRSF17               0.000000             0.0000000             0.0000000 #> ICAM3                  0.000000             0.0000000             0.0000000 #> FAP                    1.755288             0.3364709             0.4353406 #> GZMB                   0.000000             0.1696720             0.0000000 #> TSC2                   0.000000             0.0000000             0.0000000 #>          X41_Y-102..Endothelial X65_Y-85..Endothelial X62_Y-85..Endothelial #> PDK4                          0              1.656274                     0 #> TNFRSF17                      0              0.000000                     0 #> ICAM3                         0              0.000000                     0 #> FAP                           0              0.000000                     0 #> GZMB                          0              0.000000                     0 #> TSC2                          0              0.000000                     0 #>          X62_Y-86..Endothelial X64_Y-86..Endothelial X65_Y-86..Endothelial #> PDK4                 0.0000000             0.8065841             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.6301272             0.0000000             0.0000000 #> GZMB                 0.2719883             0.9983597             0.9265527 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X63_Y-86..Endothelial X60_Y-86..Endothelial X62_Y-87..Endothelial #> PDK4                 0.9388408              0.000000             0.0000000 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.5920186              0.000000             0.0000000 #> GZMB                 0.0000000              1.475526             0.7615673 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X61_Y-87..Endothelial X63_Y-87..Endothelial X63_Y-88..Endothelial #> PDK4                         0             1.1270575             0.0000000 #> TNFRSF17                     0             0.0000000             0.0000000 #> ICAM3                        0             0.0000000             0.0000000 #> FAP                          0             0.0000000             0.9363286 #> GZMB                         0             0.3038826             0.7597065 #> TSC2                         0             0.0000000             0.0000000 #>          X64_Y-88..Endothelial X64_Y-89..Endothelial X61_Y-89..Endothelial #> PDK4                  1.406274              1.129858              0.975044 #> TNFRSF17              0.000000              0.000000              0.000000 #> ICAM3                 0.000000              0.000000              0.000000 #> FAP                   0.000000              1.129858              1.123464 #> GZMB                  0.000000              0.000000              0.000000 #> TSC2                  0.000000              0.000000              0.000000 #>          X66_Y-89..Endothelial X63_Y-89..Endothelial X60_Y-90..Endothelial #> PDK4                         0                     0              0.000000 #> TNFRSF17                     0                     0              0.000000 #> ICAM3                        0                     0              0.000000 #> FAP                          0                     0              1.000756 #> GZMB                         0                     0              0.000000 #> TSC2                         0                     0              0.000000 #>          X62_Y-90..Endothelial X65_Y-90..Endothelial X63_Y-90..Endothelial #> PDK4                  2.925132             0.5477196                     0 #> TNFRSF17              0.000000             0.0000000                     0 #> ICAM3                 0.000000             0.0000000                     0 #> FAP                   0.000000             0.0000000                     0 #> GZMB                  0.000000             0.0000000                     0 #> TSC2                  0.000000             0.0000000                     0 #>          X64_Y-90..Endothelial X62_Y-91..Endothelial X62_Y-89..Endothelial #> PDK4                 1.3250339              0.000000                     0 #> TNFRSF17             0.0000000              0.000000                     0 #> ICAM3                0.0000000              0.000000                     0 #> FAP                  0.3681734              1.935062                     0 #> GZMB                 1.0544812              0.000000                     0 #> TSC2                 0.0000000              0.000000                     0 #>          X64_Y-91..Endothelial X38_Y-91..Endothelial X39_Y-92..Endothelial #> PDK4                 0.9666049             0.5172763             1.2155913 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.4207695             0.2957626             0.7490070 #> GZMB                 1.2051214             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.3971863 #>          X40_Y-92..Endothelial X36_Y-93..Endothelial X39_Y-93..Endothelial #> PDK4                 0.2178568             1.1266113             1.0722352 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.3895993             0.6216184 #> GZMB                 0.0000000             0.0000000             0.1745932 #> TSC2                 0.0000000             0.2004158             0.0000000 #>          X40_Y-93..Endothelial X38_Y-93..Endothelial X37_Y-93..Endothelial #> PDK4                 0.3545521              1.418861             0.4517058 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.1503602              0.220657             0.5553808 #> GZMB                 0.0000000              0.000000             0.0000000 #> TSC2                 0.1620710              0.000000             0.0000000 #>          X40_Y-94..Endothelial X36_Y-94..Endothelial X38_Y-94..Endothelial #> PDK4                 0.6195664             0.9406391             0.9222596 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.3895993             0.1434270 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.2004158             0.2110592 #>          X39_Y-94..Endothelial X37_Y-94..Endothelial X40_Y-95..Endothelial #> PDK4                 0.8926713             0.8175434             0.8900997 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.3170662             0.0000000             0.7442852 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.2004158             0.1973346 #>          X36_Y-95..Endothelial X39_Y-95..Endothelial X37_Y-95..Endothelial #> PDK4                  1.649686                     0             1.5397069 #> TNFRSF17              0.000000                     0             0.0000000 #> ICAM3                 0.000000                     0             0.0000000 #> FAP                   0.000000                     0             0.0000000 #> GZMB                  0.000000                     0             0.0000000 #> TSC2                  0.000000                     0             0.2243321 #>          X38_Y-95..Endothelial X38_Y-96..Endothelial X37_Y-96..Endothelial #> PDK4                 0.7514488             0.8668514             1.2782097 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.2854844             0.9569564 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.6047621 #>          X41_Y-96..Endothelial X40_Y-96..Endothelial X39_Y-96..Endothelial #> PDK4                 1.7582626             1.0023142             1.1275784 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.4966501             0.5391215             0.1604389 #> GZMB                 0.0000000             0.0000000             0.2044219 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X41_Y-94..Endothelial X38_Y-104..Endothelial X41_Y-104..Endothelial #> PDK4                 0.2991142               1.252499              0.9403977 #> TNFRSF17             0.0000000               0.000000              0.0000000 #> ICAM3                0.0000000               0.000000              0.0000000 #> FAP                  0.2506004               1.252499              0.9403977 #> GZMB                 0.0000000               0.000000              0.0000000 #> TSC2                 0.0000000               0.000000              0.0000000 #>          X40_Y-104..Endothelial X40_Y-105..Endothelial X38_Y-105..Endothelial #> PDK4                   1.253864                      0                 1.4115 #> TNFRSF17               0.000000                      0                 0.0000 #> ICAM3                  0.000000                      0                 0.0000 #> FAP                    1.253864                      0                 0.0000 #> GZMB                   0.000000                      0                 0.0000 #> TSC2                   0.000000                      0                 0.0000 #>          X37_Y-105..Endothelial X41_Y-105..Endothelial X37_Y-106..Endothelial #> PDK4                   3.069628               2.579415              1.4365625 #> TNFRSF17               0.000000               0.000000              0.0000000 #> ICAM3                  0.000000               0.000000              0.0000000 #> FAP                    0.000000               0.000000              0.5019920 #> GZMB                   0.000000               1.273616              0.1960712 #> TSC2                   0.000000               0.000000              0.0000000 #>          X38_Y-106..Endothelial X37_Y-107..Endothelial X41_Y-107..Endothelial #> PDK4                  1.0343460              1.1715585               2.473003 #> TNFRSF17              0.0000000              0.0000000               0.000000 #> ICAM3                 0.0000000              0.0000000               0.000000 #> FAP                   0.6431575              0.5610499               0.000000 #> GZMB                  0.3386684              0.2191383               0.000000 #> TSC2                  0.0000000              0.0000000               0.000000 #>          X38_Y-107..Endothelial X52_Y-86..Endothelial X53_Y-86..Endothelial #> PDK4                          0             0.7192486             0.8990608 #> TNFRSF17                      0             0.0000000             0.0000000 #> ICAM3                         0             0.0000000             0.0000000 #> FAP                           0             0.0000000             0.0000000 #> GZMB                          0             0.0000000             0.0000000 #> TSC2                          0             0.0000000             0.0000000 #>          X51_Y-86..Endothelial X55_Y-87..Endothelial X51_Y-87..Endothelial #> PDK4                   2.87698             0.4900467             1.3931292 #> TNFRSF17               0.00000             0.0000000             0.0000000 #> ICAM3                  0.00000             0.0000000             0.0000000 #> FAP                    0.00000             0.0000000             0.0000000 #> GZMB                   0.00000             0.5512442             0.0000000 #> TSC2                   0.00000             0.0000000             0.7985048 #>          X52_Y-88..Endothelial X51_Y-88..Endothelial X53_Y-89..Endothelial #> PDK4                 1.3931292              0.998131              0.000000 #> TNFRSF17             0.0000000              0.000000              0.000000 #> ICAM3                0.0000000              0.000000              0.000000 #> FAP                  0.0000000              0.000000              0.000000 #> GZMB                 0.0000000              0.000000              1.398362 #> TSC2                 0.7985048              0.998131              0.000000 #>          X49_Y-90..Endothelial X54_Y-90..Endothelial X52_Y-90..Endothelial #> PDK4                  1.177629             0.7313855             0.0000000 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             1.1510800             0.0000000 #> GZMB                  0.000000             0.3168300             0.0000000 #> TSC2                  0.000000             0.4011267             0.7820633 #>          X50_Y-90..Endothelial X53_Y-90..Endothelial X51_Y-91..Endothelial #> PDK4                  1.177629              0.000000              3.198127 #> TNFRSF17              0.000000              0.000000              0.000000 #> ICAM3                 0.000000              0.000000              0.000000 #> FAP                   1.161903              0.000000              0.000000 #> GZMB                  0.000000              1.048772              0.000000 #> TSC2                  0.000000              0.000000              0.000000 #>          X52_Y-91..Endothelial X49_Y-88..Endothelial X55_Y-85..Endothelial #> PDK4                 0.6277785                     0              1.716027 #> TNFRSF17             0.0000000                     0              0.000000 #> ICAM3                0.0000000                     0              0.000000 #> FAP                  0.5681410                     0              0.000000 #> GZMB                 0.4069144                     0              0.000000 #> TSC2                 0.0000000                     0              0.000000 #>          X58_Y-86..Endothelial X59_Y-86..Endothelial X54_Y-87..Endothelial #> PDK4                         0                     0               0.73507 #> TNFRSF17                     0                     0               0.00000 #> ICAM3                        0                     0               0.00000 #> FAP                          0                     0               0.00000 #> GZMB                         0                     0               0.00000 #> TSC2                         0                     0               0.00000 #>          X56_Y-87..Endothelial X55_Y-88..Endothelial X59_Y-88..Endothelial #> PDK4                  2.561312             0.0000000                     0 #> TNFRSF17              0.000000             0.0000000                     0 #> ICAM3                 0.000000             0.0000000                     0 #> FAP                   0.000000             0.0000000                     0 #> GZMB                  0.000000             0.4724950                     0 #> TSC2                  0.000000             0.6244327                     0 #>          X59_Y-89..Endothelial X57_Y-89..Endothelial X58_Y-89..Endothelial #> PDK4                         0             0.6269318             0.6269318 #> TNFRSF17                     0             0.0000000             0.0000000 #> ICAM3                        0             0.0000000             0.0000000 #> FAP                          0             0.0000000             0.0000000 #> GZMB                         0             0.0000000             0.0000000 #> TSC2                         0             0.0000000             0.0000000 #>          X56_Y-89..Endothelial X56_Y-90..Endothelial X61_Y-90..Endothelial #> PDK4                         0                     0              0.000000 #> TNFRSF17                     0                     0              0.000000 #> ICAM3                        0                     0              0.000000 #> FAP                          0                     0              1.000756 #> GZMB                         0                     0              0.000000 #> TSC2                         0                     0              0.000000 #>          X58_Y-91..Endothelial X60_Y-91..Endothelial X55_Y-89..Endothelial #> PDK4                  3.565702              1.329106                     0 #> TNFRSF17              0.000000              0.000000                     0 #> ICAM3                 0.000000              0.000000                     0 #> FAP                   0.000000              0.000000                     0 #> GZMB                  0.000000              0.000000                     0 #> TSC2                  3.565702              0.000000                     0 #>          X54_Y-64..Endothelial X55_Y-66..Endothelial X56_Y-66..Endothelial #> PDK4                 0.5930057               1.33232             0.6119309 #> TNFRSF17             0.0000000               0.00000             0.0000000 #> ICAM3                0.0000000               0.00000             0.0000000 #> FAP                  0.0000000               0.00000             0.0000000 #> GZMB                 0.0000000               0.00000             0.5644681 #> TSC2                 0.5192801               0.00000             0.0000000 #>          X56_Y-65..Endothelial X70_Y-64..Endothelial X72_Y-65..Endothelial #> PDK4                  1.191924                     0             0.3030154 #> TNFRSF17              0.000000                     0             0.0000000 #> ICAM3                 0.000000                     0             0.0000000 #> FAP                   0.000000                     0             0.0000000 #> GZMB                  0.000000                     0             0.7667264 #> TSC2                  0.000000                     0             0.0000000 #>          X49_Y-99..Endothelial X51_Y-99..Endothelial X53_Y-99..Endothelial #> PDK4                         0             0.0000000                     0 #> TNFRSF17                     0             0.0000000                     0 #> ICAM3                        0             0.0000000                     0 #> FAP                          0             0.2373406                     0 #> GZMB                         0             0.0000000                     0 #> TSC2                         0             0.0000000                     0 #>          X52_Y-100..Endothelial X49_Y-100..Endothelial X48_Y-100..Endothelial #> PDK4                  0.5074912               1.184393              0.0000000 #> TNFRSF17              0.0000000               0.000000              0.0000000 #> ICAM3                 0.0000000               0.000000              0.0000000 #> FAP                   0.0000000               1.184393              0.3490025 #> GZMB                  0.0000000               0.000000              0.5819433 #> TSC2                  0.0000000               0.000000              0.0000000 #>          X53_Y-100..Endothelial X52_Y-101..Endothelial X51_Y-101..Endothelial #> PDK4                   1.184146                      0              0.0000000 #> TNFRSF17               0.000000                      0              0.0000000 #> ICAM3                  0.000000                      0              0.0000000 #> FAP                    0.000000                      0              0.6324563 #> GZMB                   0.000000                      0              0.0000000 #> TSC2                   0.000000                      0              0.0000000 #>          X52_Y-103..Endothelial X54_Y-103..Endothelial X50_Y-99..Endothelial #> PDK4                   0.000000                      0              0.000000 #> TNFRSF17               0.000000                      0              0.000000 #> ICAM3                  0.000000                      0              0.000000 #> FAP                    1.682491                      0              0.514238 #> GZMB                   0.000000                      0              0.000000 #> TSC2                   1.682491                      0              0.000000 #>          X51_Y-100..Endothelial X50_Y-100..Endothelial X47_Y-98..Endothelial #> PDK4                  0.0000000              0.9459142                     0 #> TNFRSF17              0.0000000              0.0000000                     0 #> ICAM3                 0.0000000              0.0000000                     0 #> FAP                   0.3085428              0.9459142                     0 #> GZMB                  0.0000000              0.0000000                     0 #> TSC2                  0.0000000              0.0000000                     0 #>          X44_Y-98..Endothelial X43_Y-99..Endothelial X43_Y-100..Endothelial #> PDK4                         0             0.7421974              0.9438961 #> TNFRSF17                     0             0.0000000              0.0000000 #> ICAM3                        0             0.0000000              0.0000000 #> FAP                          0             0.0000000              0.0000000 #> GZMB                         0             0.0000000              0.0000000 #> TSC2                         0             0.0000000              0.0000000 #>          X44_Y-100..Endothelial X46_Y-100..Endothelial X47_Y-100..Endothelial #> PDK4                   1.153651                      0              0.0000000 #> TNFRSF17               0.000000                      0              0.0000000 #> ICAM3                  0.000000                      0              0.0000000 #> FAP                    0.000000                      0              0.3490025 #> GZMB                   0.000000                      0              0.0000000 #> TSC2                   0.000000                      0              0.0000000 #>          X47_Y-101..Endothelial X48_Y-101..Endothelial X42_Y-101..Endothelial #> PDK4                          0               0.000000                      0 #> TNFRSF17                      0               0.000000                      0 #> ICAM3                         0               0.000000                      0 #> FAP                           0               0.000000                      0 #> GZMB                          0               1.163887                      0 #> TSC2                          0               0.000000                      0 #>          X46_Y-102..Endothelial X47_Y-102..Endothelial X44_Y-99..Endothelial #> PDK4                  1.2110288              1.2110288             0.9438961 #> TNFRSF17              0.0000000              0.0000000             0.0000000 #> ICAM3                 0.0000000              0.0000000             0.0000000 #> FAP                   0.0000000              0.0000000             0.0000000 #> GZMB                  0.5744422              0.5744422             0.0000000 #> TSC2                  0.0000000              0.0000000             0.0000000 #>          X42_Y-102..Endothelial X27_Y-91..Fibroblast X28_Y-91..Fibroblast #> PDK4                  0.8377341            0.4690205            0.7758785 #> TNFRSF17              0.0000000            0.0000000            0.0000000 #> ICAM3                 0.0000000            0.0000000            0.0000000 #> FAP                   0.7021152            1.3725327            0.5732353 #> GZMB                  0.0000000            0.0000000            0.0000000 #> TSC2                  0.0000000            0.0000000            0.0000000 #>          X25_Y-91..Fibroblast X24_Y-91..Fibroblast X26_Y-91..Fibroblast #> PDK4                  0.00000             0.000000             0.000000 #> TNFRSF17              0.00000             0.000000             0.000000 #> ICAM3                 0.00000             0.000000             0.000000 #> FAP                   0.63572             1.864123             2.197225 #> GZMB                  0.00000             0.000000             0.000000 #> TSC2                  0.00000             0.000000             0.000000 #>          X27_Y-92..Fibroblast X29_Y-92..Fibroblast X28_Y-92..Fibroblast #> PDK4                0.5071629             1.171116            0.6645528 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 2.5937838             0.000000            1.2200737 #> GZMB                0.5037227             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.0000000 #>          X23_Y-92..Fibroblast X24_Y-93..Fibroblast X26_Y-92..Fibroblast #> PDK4                0.0000000             1.411532                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 0.8994922             1.338280                    0 #> GZMB                0.0000000             0.000000                    0 #> TSC2                0.0000000             0.000000                    0 #>          X28_Y-93..Fibroblast X27_Y-93..Fibroblast X26_Y-93..Fibroblast #> PDK4                0.9032266            0.7262602            0.9866613 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.9044899            1.7883209            0.9596186 #> GZMB                0.0000000            0.4477535            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X30_Y-93..Fibroblast X29_Y-93..Fibroblast X23_Y-93..Fibroblast #> PDK4                1.3066659            0.8397811            0.6186864 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.2771736            0.0000000            1.3382802 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X25_Y-93..Fibroblast X28_Y-94..Fibroblast X30_Y-94..Fibroblast #> PDK4                        0            0.6568920            0.3994954 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.3324332            1.0500234 #> GZMB                        0            0.0000000            0.2671440 #> TSC2                        0            0.0000000            0.0000000 #>          X24_Y-94..Fibroblast X27_Y-94..Fibroblast X29_Y-94..Fibroblast #> PDK4                        0            0.4113680            0.8246360 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.6058897            0.7115480 #> GZMB                        0            0.0000000            0.2938584 #> TSC2                        0            0.0000000            0.0000000 #>          X25_Y-94..Fibroblast X26_Y-95..Fibroblast X24_Y-95..Fibroblast #> PDK4                0.4903299            0.4773087                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.0000000            0.5880101                    0 #> GZMB                0.0000000            0.0000000                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X28_Y-95..Fibroblast X27_Y-95..Fibroblast X30_Y-95..Fibroblast #> PDK4                        0            1.0572410            0.7185323 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            1.1426720            0.5824929 #> GZMB                        0            0.5546619            0.0000000 #> TSC2                        0            0.0000000            0.0000000 #>          X26_Y-96..Fibroblast X24_Y-96..Fibroblast X25_Y-96..Fibroblast #> PDK4                1.1934408            1.5941933                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 1.1800831            0.8786722                    0 #> GZMB                0.6028609            0.0000000                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X24_Y-97..Fibroblast X29_Y-97..Fibroblast X25_Y-97..Fibroblast #> PDK4                1.1438588            0.0000000            0.8723152 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.2409568            0.8595345            1.2402291 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X23_Y-97..Fibroblast X26_Y-98..Fibroblast X27_Y-98..Fibroblast #> PDK4                0.8581254             1.060324                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 0.9555936             1.400502                    0 #> GZMB                0.0000000             0.000000                    0 #> TSC2                0.0000000             0.000000                    0 #>          X25_Y-92..Fibroblast X24_Y-92..Fibroblast X25_Y-95..Fibroblast #> PDK4                 0.000000             1.982114            0.7354948 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  1.279491             0.000000            0.0000000 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X27_Y-96..Fibroblast X29_Y-96..Fibroblast X26_Y-97..Fibroblast #> PDK4                0.6959188                    0            1.0370591 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 1.4672574                    0            1.5300209 #> GZMB                0.6655943                    0            0.5167379 #> TSC2                0.0000000                    0            0.0000000 #>          X28_Y-97..Fibroblast X62_Y-91..Fibroblast X65_Y-92..Fibroblast #> PDK4                        0            0.7625637                    0 #> TNFRSF17                    0            0.0000000                    0 #> ICAM3                       0            0.0000000                    0 #> FAP                         0            0.8460130                    0 #> GZMB                        0            1.0706502                    0 #> TSC2                        0            0.0000000                    0 #>          X64_Y-92..Fibroblast X61_Y-92..Fibroblast X65_Y-93..Fibroblast #> PDK4                        0             0.000000            0.0000000 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             2.807459            0.7606549 #> GZMB                        0             1.123547            0.0000000 #> TSC2                        0             0.000000            0.0000000 #>          X66_Y-93..Fibroblast X61_Y-93..Fibroblast X62_Y-94..Fibroblast #> PDK4                        0             0.000000            0.8328684 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             1.705995            0.0000000 #> GZMB                        0             0.000000            0.0000000 #> TSC2                        0             0.000000            0.0000000 #>          X63_Y-94..Fibroblast X65_Y-94..Fibroblast X66_Y-94..Fibroblast #> PDK4                0.3018114                    0             0.000000 #> TNFRSF17            0.0000000                    0             0.000000 #> ICAM3               0.0000000                    0             0.000000 #> FAP                 0.3029910                    0             1.365733 #> GZMB                0.0000000                    0             0.000000 #> TSC2                0.0000000                    0             0.000000 #>          X61_Y-94..Fibroblast X64_Y-94..Fibroblast X62_Y-95..Fibroblast #> PDK4                 0.000000                    0            0.2263585 #> TNFRSF17             0.000000                    0            0.0000000 #> ICAM3                0.000000                    0            0.0000000 #> FAP                  1.773711                    0            0.6163538 #> GZMB                 0.000000                    0            0.0000000 #> TSC2                 0.000000                    0            0.0000000 #>          X63_Y-95..Fibroblast X65_Y-95..Fibroblast X64_Y-95..Fibroblast #> PDK4                0.2716302             0.000000                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 0.3449600             1.085262                    0 #> GZMB                0.4008316             0.000000                    0 #> TSC2                0.0000000             0.000000                    0 #>          X66_Y-95..Fibroblast X61_Y-95..Fibroblast X60_Y-95..Fibroblast #> PDK4                 0.000000            0.3961696            0.7898948 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.279202            0.3181991            0.6511375 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X67_Y-95..Fibroblast X61_Y-96..Fibroblast X62_Y-96..Fibroblast #> PDK4                0.0000000            0.4952121            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.1745012            0.0000000            1.2702909 #> GZMB                0.2034810            1.0231393            0.7222006 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X67_Y-96..Fibroblast X66_Y-96..Fibroblast X63_Y-96..Fibroblast #> PDK4                0.0000000             0.000000            0.6088494 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.6918861             1.214368            1.0156572 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.0000000 #>          X60_Y-96..Fibroblast X61_Y-97..Fibroblast X62_Y-97..Fibroblast #> PDK4                0.0000000            0.2280805            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.6260271            0.4169211            0.4100490 #> GZMB                0.0000000            0.2751365            0.4814671 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X63_Y-97..Fibroblast X60_Y-97..Fibroblast X64_Y-97..Fibroblast #> PDK4                        0            0.5139001                    0 #> TNFRSF17                    0            0.0000000                    0 #> ICAM3                       0            0.0000000                    0 #> FAP                         0            0.5134118                    0 #> GZMB                        0            0.0000000                    0 #> TSC2                        0            0.0000000                    0 #>          X62_Y-98..Fibroblast X62_Y-92..Fibroblast X60_Y-94..Fibroblast #> PDK4                0.3314364            0.0000000             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.3194301            1.7091850             1.601467 #> GZMB                0.0000000            1.7553580             0.000000 #> TSC2                0.0000000            0.6671558             0.000000 #>          X54_Y-91..Fibroblast X56_Y-91..Fibroblast X60_Y-91..Fibroblast #> PDK4                0.8627328            0.4603509            0.7664300 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.7735483            0.2338288            1.7632592 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.9968292 #>          X57_Y-91..Fibroblast X56_Y-92..Fibroblast X55_Y-92..Fibroblast #> PDK4                  0.00000            0.4357487            0.1562593 #> TNFRSF17              0.00000            0.0000000            0.0000000 #> ICAM3                 0.00000            0.0000000            0.0000000 #> FAP                   2.08092            0.4390914            1.2628491 #> GZMB                  0.00000            0.0000000            0.0000000 #> TSC2                  0.00000            0.0000000            0.0000000 #>          X54_Y-92..Fibroblast X58_Y-92..Fibroblast X57_Y-92..Fibroblast #> PDK4                0.0000000             0.000000             0.281404 #> TNFRSF17            0.0000000             0.000000             0.000000 #> ICAM3               0.0000000             0.000000             0.000000 #> FAP                 1.0016055             1.061403             0.000000 #> GZMB                0.2214762             0.000000             0.000000 #> TSC2                0.0000000             0.000000             0.000000 #>          X60_Y-92..Fibroblast X57_Y-93..Fibroblast X56_Y-93..Fibroblast #> PDK4                 0.000000            0.0000000             0.000000 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  1.144018            0.5738042             1.291583 #> GZMB                 0.000000            0.0000000             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X59_Y-93..Fibroblast X55_Y-93..Fibroblast X58_Y-93..Fibroblast #> PDK4                        0             0.000000            0.4676017 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             1.934681            0.8596109 #> GZMB                        0             0.000000            0.0000000 #> TSC2                        0             0.000000            0.0000000 #>          X60_Y-93..Fibroblast X57_Y-94..Fibroblast X58_Y-94..Fibroblast #> PDK4                0.0000000            0.0000000            0.2651659 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.7453124            0.7915595            0.6301798 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X59_Y-94..Fibroblast X55_Y-94..Fibroblast X56_Y-94..Fibroblast #> PDK4                0.3836174            0.9596219                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.4242963            0.5165802                    0 #> GZMB                0.0000000            0.0000000                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X54_Y-94..Fibroblast X54_Y-95..Fibroblast X58_Y-95..Fibroblast #> PDK4                1.4490471            1.5854221            0.4413181 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.4809532            0.6919206            0.4413181 #> GZMB                0.2374912            0.2226480            0.9843379 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X57_Y-95..Fibroblast X59_Y-95..Fibroblast X56_Y-95..Fibroblast #> PDK4                0.5433446            0.0000000            0.6799623 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.9089941            1.3661879            0.2206729 #> GZMB                0.6327887            0.0000000            0.0000000 #> TSC2                0.0000000            0.3282181            0.0000000 #>          X55_Y-95..Fibroblast X59_Y-96..Fibroblast X56_Y-96..Fibroblast #> PDK4                0.5433155             0.000000            0.6538346 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 1.0323111             1.257814            0.6934370 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.2227370             0.000000            0.0000000 #>          X55_Y-96..Fibroblast X58_Y-96..Fibroblast X57_Y-96..Fibroblast #> PDK4                0.1928238            0.7192598            0.4577108 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.5554458            0.5522198            0.6239213 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.2712497 #>          X59_Y-97..Fibroblast X55_Y-97..Fibroblast X57_Y-97..Fibroblast #> PDK4                0.0000000            0.3971863            0.3356546 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.9229653            0.8031651            0.0000000 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.3971863            0.1989165 #>          X54_Y-97..Fibroblast X58_Y-97..Fibroblast X60_Y-98..Fibroblast #> PDK4                 0.000000            0.5869769            0.4063073 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.519413            0.1982082            0.4462566 #> GZMB                 1.519413            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X57_Y-98..Fibroblast X56_Y-97..Fibroblast X59_Y-98..Fibroblast #> PDK4                0.0000000            0.0000000             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.9999605            0.5483143             0.905126 #> GZMB                0.4440807            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.223361 #>          X55_Y-98..Fibroblast X74_Y-97..Fibroblast X75_Y-97..Fibroblast #> PDK4                0.0000000            0.2721114            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.0915618            0.6726096            0.0000000 #> GZMB                0.3386684            0.0000000            0.4605453 #> TSC2                0.0000000            0.2721114            0.0000000 #>          X73_Y-97..Fibroblast X76_Y-97..Fibroblast X75_Y-98..Fibroblast #> PDK4                0.3796169            0.2999922             1.141870 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.4770613            0.6570646             1.326707 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X77_Y-98..Fibroblast X73_Y-98..Fibroblast X78_Y-98..Fibroblast #> PDK4                1.6973220                    0            1.0088059 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.7309858                    0            0.7384907 #> GZMB                0.0000000                    0            0.0000000 #> TSC2                0.0000000                    0            0.0000000 #>          X76_Y-98..Fibroblast X76_Y-99..Fibroblast X75_Y-99..Fibroblast #> PDK4                0.6467944             0.000000            0.3740742 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.9659376             1.122758            1.3426344 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.0000000 #>          X74_Y-99..Fibroblast X77_Y-99..Fibroblast X76_Y-100..Fibroblast #> PDK4                 0.000000                    0             0.0000000 #> TNFRSF17             0.000000                    0             0.0000000 #> ICAM3                0.000000                    0             0.0000000 #> FAP                  1.525671                    0             0.7615673 #> GZMB                 0.000000                    0             0.0000000 #> TSC2                 0.000000                    0             0.0000000 #>          X74_Y-100..Fibroblast X73_Y-100..Fibroblast X75_Y-100..Fibroblast #> PDK4                 0.0000000             0.3613437             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.9189617             0.3817621             0.9104364 #> GZMB                 0.3627947             0.0000000             0.0000000 #> TSC2                 0.0000000             0.4997199             0.0000000 #>          X77_Y-100..Fibroblast X72_Y-100..Fibroblast X78_Y-100..Fibroblast #> PDK4                 0.0000000             0.2627954              0.000000 #> TNFRSF17             0.0000000             0.0000000              0.000000 #> ICAM3                0.0000000             0.0000000              0.000000 #> FAP                  2.9905066             0.2776451              1.748738 #> GZMB                 0.0000000             0.0000000              0.000000 #> TSC2                 0.7178741             0.3634326              0.000000 #>          X74_Y-101..Fibroblast X78_Y-101..Fibroblast X73_Y-101..Fibroblast #> PDK4                  0.000000                     0             0.0000000 #> TNFRSF17              0.000000                     0             0.0000000 #> ICAM3                 0.000000                     0             0.0000000 #> FAP                   1.037089                     0             0.7111473 #> GZMB                  0.000000                     0             0.0000000 #> TSC2                  0.000000                     0             0.0000000 #>          X76_Y-101..Fibroblast X77_Y-101..Fibroblast X78_Y-102..Fibroblast #> PDK4                         0              0.688743                     0 #> TNFRSF17                     0              0.000000                     0 #> ICAM3                        0              0.000000                     0 #> FAP                          0              0.000000                     0 #> GZMB                         0              0.000000                     0 #> TSC2                         0              0.000000                     0 #>          X74_Y-102..Fibroblast X77_Y-102..Fibroblast X75_Y-103..Fibroblast #> PDK4                         0             0.9535679             0.4478184 #> TNFRSF17                     0             0.0000000             0.0000000 #> ICAM3                        0             0.0000000             0.0000000 #> FAP                          0             1.0474308             0.3834590 #> GZMB                         0             0.0000000             0.0000000 #> TSC2                         0             0.0000000             0.0000000 #>          X77_Y-103..Fibroblast X78_Y-103..Fibroblast X74_Y-103..Fibroblast #> PDK4                 0.9574006             0.8285690             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.6173089             0.3609429             0.5495108 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X75_Y-104..Fibroblast X77_Y-104..Fibroblast X74_Y-104..Fibroblast #> PDK4                 0.0000000              0.913731             0.0000000 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.8364593              2.048370             0.8816144 #> GZMB                 0.0000000              0.000000             0.0000000 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X76_Y-104..Fibroblast X74_Y-98..Fibroblast X72_Y-99..Fibroblast #> PDK4                 0.7611306            0.0000000            0.0000000 #> TNFRSF17             0.0000000            0.0000000            0.0000000 #> ICAM3                0.0000000            0.0000000            0.0000000 #> FAP                  1.6120107            0.9383844            0.7742138 #> GZMB                 0.0000000            0.0000000            0.0000000 #> TSC2                 0.0000000            0.0000000            0.0000000 #>          X73_Y-99..Fibroblast X73_Y-102..Fibroblast X75_Y-102..Fibroblast #> PDK4                        0                     0                     0 #> TNFRSF17                    0                     0                     0 #> ICAM3                       0                     0                     0 #> FAP                         0                     0                     0 #> GZMB                        0                     0                     0 #> TSC2                        0                     0                     0 #>          X76_Y-102..Fibroblast X73_Y-103..Fibroblast X76_Y-103..Fibroblast #> PDK4                  1.300952                     0             0.8956368 #> TNFRSF17              0.000000                     0             0.0000000 #> ICAM3                 0.000000                     0             0.0000000 #> FAP                   1.300952                     0             0.0000000 #> GZMB                  0.000000                     0             0.0000000 #> TSC2                  0.000000                     0             0.0000000 #>          X76_Y-85..Fibroblast X75_Y-85..Fibroblast X74_Y-85..Fibroblast #> PDK4                        0             0.000000            0.0000000 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             1.113367            1.2145823 #> GZMB                        0             0.259995            0.2836309 #> TSC2                        0             0.000000            0.0000000 #>          X73_Y-85..Fibroblast X77_Y-85..Fibroblast X74_Y-86..Fibroblast #> PDK4                        0            0.0000000            0.0000000 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.6700319            0.5688769 #> GZMB                        0            0.0000000            0.0000000 #> TSC2                        0            0.0000000            0.0000000 #>          X73_Y-86..Fibroblast X78_Y-86..Fibroblast X75_Y-86..Fibroblast #> PDK4                0.0000000                    0            0.0000000 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.4977673                    0            0.8038857 #> GZMB                0.0000000                    0            0.0000000 #> TSC2                0.0000000                    0            0.0000000 #>          X76_Y-86..Fibroblast X77_Y-86..Fibroblast X74_Y-87..Fibroblast #> PDK4                0.0000000            0.8133253             1.221356 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.4113262            0.0000000             1.221356 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X73_Y-87..Fibroblast X72_Y-87..Fibroblast X76_Y-87..Fibroblast #> PDK4                 0.000000            0.2808659            0.0000000 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.464718            0.9585520            0.3647169 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X75_Y-87..Fibroblast X78_Y-87..Fibroblast X77_Y-87..Fibroblast #> PDK4                 0.000000             0.000000            0.9077021 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  0.863337             1.272164            0.3299170 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X78_Y-88..Fibroblast X77_Y-88..Fibroblast X75_Y-88..Fibroblast #> PDK4                0.0000000            0.8016631            0.4927100 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.7632981            0.5278672            0.4530305 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X72_Y-88..Fibroblast X76_Y-88..Fibroblast X73_Y-88..Fibroblast #> PDK4                 0.000000             0.788336            0.0000000 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  1.089685             1.568777            0.3259957 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X74_Y-89..Fibroblast X76_Y-89..Fibroblast X73_Y-89..Fibroblast #> PDK4                        0            0.0000000            0.2899662 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            1.1205549            0.3712986 #> GZMB                        0            0.7869986            0.0000000 #> TSC2                        0            0.6190291            0.0000000 #>          X75_Y-89..Fibroblast X78_Y-89..Fibroblast X74_Y-90..Fibroblast #> PDK4                0.0000000             0.000000            0.0000000 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.0000000             1.944345            0.0000000 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.6190291             0.000000            0.4902589 #>          X75_Y-90..Fibroblast X73_Y-90..Fibroblast X76_Y-90..Fibroblast #> PDK4                 0.000000            0.0000000            0.9793078 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.714482            0.5280041            0.7030943 #> GZMB                 0.000000            0.2309652            0.0000000 #> TSC2                 0.000000            0.2614714            0.0000000 #>          X78_Y-90..Fibroblast X77_Y-90..Fibroblast X75_Y-91..Fibroblast #> PDK4                0.0000000            0.6528718            0.5744395 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.7777381            0.0000000            0.8268103 #> GZMB                2.2657116            0.0000000            0.5483225 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X78_Y-91..Fibroblast X77_Y-91..Fibroblast X74_Y-91..Fibroblast #> PDK4                0.0000000             0.000000             0.000000 #> TNFRSF17            0.0000000             0.000000             0.000000 #> ICAM3               0.0000000             0.000000             0.000000 #> FAP                 0.4619123             1.039303             1.511313 #> GZMB                1.2587287             0.000000             0.000000 #> TSC2                0.0000000             0.000000             0.000000 #>          X79_Y-91..Fibroblast X73_Y-91..Fibroblast X72_Y-91..Fibroblast #> PDK4                0.0000000             0.000000            0.0000000 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.8277628             2.357098            0.2534289 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.0000000 #>          X72_Y-86..Fibroblast X77_Y-89..Fibroblast X72_Y-90..Fibroblast #> PDK4                 0.000000            0.6528718            0.0000000 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.074576            0.0000000            0.5451169 #> GZMB                 0.000000            0.9181650            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X76_Y-91..Fibroblast X35_Y-72..Fibroblast X30_Y-72..Fibroblast #> PDK4                 0.000000            0.5293999            0.8103472 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.331865            0.9908267            0.0000000 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X35_Y-73..Fibroblast X30_Y-74..Fibroblast X32_Y-74..Fibroblast #> PDK4                1.2175479                    0            0.5974709 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.3845169                    0            1.1311013 #> GZMB                0.0000000                    0            0.0000000 #> TSC2                0.0000000                    0            0.0000000 #>          X33_Y-74..Fibroblast X32_Y-75..Fibroblast X33_Y-75..Fibroblast #> PDK4                        0            0.5227870            0.6970494 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.9765159            0.0000000 #> GZMB                        0            0.0000000            0.0000000 #> TSC2                        0            0.0000000            0.0000000 #>          X30_Y-75..Fibroblast X34_Y-76..Fibroblast X32_Y-77..Fibroblast #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X33_Y-77..Fibroblast X35_Y-78..Fibroblast X29_Y-78..Fibroblast #> PDK4                 2.663536            0.6636118                    0 #> TNFRSF17             0.000000            0.0000000                    0 #> ICAM3                0.000000            0.0000000                    0 #> FAP                  0.000000            0.0000000                    0 #> GZMB                 0.000000            0.0000000                    0 #> TSC2                 0.000000            0.0000000                    0 #>          X34_Y-78..Fibroblast X32_Y-78..Fibroblast X31_Y-78..Fibroblast #> PDK4                0.0000000                    0             1.402683 #> TNFRSF17            0.0000000                    0             0.000000 #> ICAM3               0.0000000                    0             0.000000 #> FAP                 0.8845006                    0             1.402683 #> GZMB                0.0000000                    0             0.000000 #> TSC2                0.0000000                    0             0.000000 #>          X30_Y-79..Fibroblast X32_Y-79..Fibroblast X33_Y-73..Fibroblast #> PDK4                 2.069451                    0            0.5327587 #> TNFRSF17             0.000000                    0            0.0000000 #> ICAM3                0.000000                    0            0.0000000 #> FAP                  0.000000                    0            0.0000000 #> GZMB                 0.000000                    0            0.0000000 #> TSC2                 0.000000                    0            0.0000000 #>          X34_Y-73..Fibroblast X31_Y-73..Fibroblast X36_Y-73..Fibroblast #> PDK4                0.0000000                    0            1.1417063 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.5700893                    0            0.7518012 #> GZMB                0.0000000                    0            0.0000000 #> TSC2                0.0000000                    0            0.0000000 #>          X32_Y-73..Fibroblast X30_Y-73..Fibroblast X36_Y-74..Fibroblast #> PDK4                        0               1.3533            0.5373701 #> TNFRSF17                    0               0.0000            0.0000000 #> ICAM3                       0               0.0000            0.0000000 #> FAP                         0               0.0000            0.0000000 #> GZMB                        0               0.0000            0.0000000 #> TSC2                        0               0.0000            0.0000000 #>          X34_Y-74..Fibroblast X35_Y-74..Fibroblast X31_Y-74..Fibroblast #> PDK4                0.0000000            0.7805710              0.00000 #> TNFRSF17            0.0000000            0.0000000              0.00000 #> ICAM3               0.0000000            0.0000000              0.00000 #> FAP                 0.7474558            0.7690338              1.76163 #> GZMB                0.0000000            0.0000000              0.00000 #> TSC2                0.0000000            0.0000000              0.00000 #>          X34_Y-75..Fibroblast X35_Y-75..Fibroblast X35_Y-76..Fibroblast #> PDK4                0.0000000            0.6898024            0.5888143 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.7474558            0.7643098            0.0000000 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X31_Y-76..Fibroblast X33_Y-76..Fibroblast X32_Y-76..Fibroblast #> PDK4                0.0000000                    0             0.000000 #> TNFRSF17            0.0000000                    0             0.000000 #> ICAM3               0.0000000                    0             0.000000 #> FAP                 0.5993738                    0             0.513749 #> GZMB                0.0000000                    0             0.000000 #> TSC2                0.0000000                    0             0.000000 #>          X35_Y-77..Fibroblast X34_Y-77..Fibroblast X33_Y-78..Fibroblast #> PDK4                 2.767023             0.000000             2.663536 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  0.000000             2.758138             0.000000 #> GZMB                 1.091693             0.000000             0.000000 #> TSC2                 0.000000             0.000000             0.000000 #>          X30_Y-78..Fibroblast X34_Y-79..Fibroblast X38_Y-66..Fibroblast #> PDK4                 2.891805             1.657803            0.7985048 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  0.000000             0.000000            0.7118093 #> GZMB                 0.000000             0.000000            0.7768031 #> TSC2                 0.000000             0.000000            0.0000000 #>          X42_Y-66..Fibroblast X37_Y-66..Fibroblast X41_Y-66..Fibroblast #> PDK4                0.4605453            0.7985048            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.4605453            0.7118093            0.0000000 #> GZMB                0.0000000            0.7768031            0.0000000 #> TSC2                0.0000000            0.0000000            0.8714273 #>          X39_Y-67..Fibroblast X42_Y-67..Fibroblast X40_Y-67..Fibroblast #> PDK4                0.6867934             1.063543             0.000000 #> TNFRSF17            0.0000000             0.000000             0.000000 #> ICAM3               0.0000000             0.000000             0.000000 #> FAP                 1.2286122             1.159904             2.660317 #> GZMB                0.0000000             0.000000             0.000000 #> TSC2                0.0000000             0.000000             0.000000 #>          X37_Y-67..Fibroblast X41_Y-67..Fibroblast X38_Y-67..Fibroblast #> PDK4                0.9981310            0.5196456             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 1.1370387            0.0000000             2.274077 #> GZMB                0.9710038            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X37_Y-68..Fibroblast X41_Y-68..Fibroblast X39_Y-68..Fibroblast #> PDK4                        0            1.1978671            2.0197100 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.4558930            0.6440826 #> GZMB                        0            0.5127912            0.0000000 #> TSC2                        0            0.0000000            0.0000000 #>          X38_Y-68..Fibroblast X40_Y-68..Fibroblast X36_Y-68..Fibroblast #> PDK4                0.8721954            0.9132741             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.0000000            0.8385641             3.005378 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.8721954            0.0000000             0.000000 #>          X35_Y-68..Fibroblast X42_Y-68..Fibroblast X39_Y-69..Fibroblast #> PDK4                        0             1.126072            0.9324426 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             0.000000            0.0000000 #> GZMB                        0             0.000000            0.5335767 #> TSC2                        0             0.000000            0.0000000 #>          X42_Y-69..Fibroblast X36_Y-69..Fibroblast X38_Y-69..Fibroblast #> PDK4                0.8594967            0.6360818            0.8446870 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.5712218            0.0000000            0.4407518 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X41_Y-69..Fibroblast X40_Y-69..Fibroblast X37_Y-69..Fibroblast #> PDK4                0.8762375            0.5749334             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.9216902            0.5749334             2.042952 #> GZMB                0.5768901            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X38_Y-70..Fibroblast X39_Y-70..Fibroblast X41_Y-70..Fibroblast #> PDK4                 1.032665            0.8263053             0.000000 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  1.398745            0.6890266             1.379708 #> GZMB                 0.000000            0.4742904             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X40_Y-70..Fibroblast X37_Y-70..Fibroblast X42_Y-70..Fibroblast #> PDK4                0.5992261            0.5898931            0.3176795 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.3928732            0.5241849            1.0327700 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X41_Y-71..Fibroblast X37_Y-71..Fibroblast X38_Y-71..Fibroblast #> PDK4                0.9815700            0.7334163                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.6857736            0.3865539                    0 #> GZMB                0.0000000            0.0000000                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X42_Y-71..Fibroblast X39_Y-71..Fibroblast X35_Y-71..Fibroblast #> PDK4                 0.536774            0.0000000             0.000000 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  1.656300            0.4160269             1.610665 #> GZMB                 0.000000            0.0000000             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X36_Y-71..Fibroblast X40_Y-71..Fibroblast X37_Y-72..Fibroblast #> PDK4                 1.011550            0.9346924            2.4313316 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.075992            0.5720370            0.6368415 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X39_Y-72..Fibroblast X36_Y-72..Fibroblast X40_Y-72..Fibroblast #> PDK4                1.3800636            0.6176332            0.4245386 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.7498715            0.0000000            0.3459727 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X38_Y-72..Fibroblast X41_Y-72..Fibroblast X41_Y-73..Fibroblast #> PDK4                0.3849338                    0            0.6246509 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.4686697                    0            1.6202404 #> GZMB                0.0000000                    0            0.0000000 #> TSC2                0.0000000                    0            0.0000000 #>          X40_Y-73..Fibroblast X39_Y-73..Fibroblast X38_Y-73..Fibroblast #> PDK4                0.3966474            0.3421634            0.2719097 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.8436190            1.2134860            0.0000000 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X37_Y-73..Fibroblast X36_Y-70..Fibroblast X42_Y-73..Fibroblast #> PDK4                1.7271793            0.9541226            0.6727009 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.9114501            0.7862774            1.7448743 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X41_Y-74..Fibroblast X40_Y-74..Fibroblast X39_Y-74..Fibroblast #> PDK4                0.6482064            0.3142794            0.8062784 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.6604051            1.4008107            1.6551299 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.4345690            0.2230008 #>          X38_Y-74..Fibroblast X37_Y-74..Fibroblast X39_Y-75..Fibroblast #> PDK4                        0                    0            1.0795430 #> TNFRSF17                    0                    0            0.0000000 #> ICAM3                       0                    0            0.0000000 #> FAP                         0                    0            0.9359458 #> GZMB                        0                    0            0.0000000 #> TSC2                        0                    0            0.0000000 #>          X36_Y-75..Fibroblast X40_Y-75..Fibroblast X38_Y-75..Fibroblast #> PDK4                0.6269318            0.8528679            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            1.2099439            1.4640247 #> GZMB                0.0000000            0.0000000            0.4600590 #> TSC2                0.0000000            0.0000000            0.5321931 #>          X42_Y-75..Fibroblast X41_Y-75..Fibroblast X40_Y-76..Fibroblast #> PDK4                0.7957226              1.29623            0.5254331 #> TNFRSF17            0.0000000              0.00000            0.0000000 #> ICAM3               0.0000000              0.00000            0.0000000 #> FAP                 1.3086876              0.00000            1.5540830 #> GZMB                0.0000000              0.00000            0.3611003 #> TSC2                0.3888691              1.29623            0.0000000 #>          X41_Y-76..Fibroblast X39_Y-76..Fibroblast X36_Y-76..Fibroblast #> PDK4                0.3533089            0.8092005            0.8703865 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 2.9008575            1.9115802            0.8289816 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X37_Y-76..Fibroblast X38_Y-76..Fibroblast X39_Y-77..Fibroblast #> PDK4                0.0000000             0.000000            0.4945816 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.6628311             1.218539            0.4124863 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.0000000 #>          X40_Y-77..Fibroblast X36_Y-77..Fibroblast X41_Y-77..Fibroblast #> PDK4                0.3508843            0.5439916             2.073263 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 1.2585815            0.5398094             2.762419 #> GZMB                0.4814671            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X38_Y-77..Fibroblast X37_Y-77..Fibroblast X42_Y-77..Fibroblast #> PDK4                0.7659193            0.5744395             0.661493 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 1.1308601            0.9123334             0.000000 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X37_Y-78..Fibroblast X41_Y-78..Fibroblast X38_Y-78..Fibroblast #> PDK4                0.3010868            0.7820633             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 2.6994135            1.7854727             1.088931 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X36_Y-78..Fibroblast X40_Y-78..Fibroblast X42_Y-78..Fibroblast #> PDK4                0.3247640            0.6903094            0.5691383 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.7173527            2.9120975            0.0000000 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X38_Y-79..Fibroblast X36_Y-79..Fibroblast X39_Y-79..Fibroblast #> PDK4                 1.130125             1.179938            0.5483458 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  2.312751             1.580627            2.9703442 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X37_Y-79..Fibroblast X37_Y-75..Fibroblast X42_Y-79..Fibroblast #> PDK4                0.4605881            0.0000000            0.6704715 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.7165719            0.7450704            0.2633319 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.2782435            0.7450704            0.3455523 #>          X73_Y-72..Fibroblast X75_Y-73..Fibroblast X76_Y-73..Fibroblast #> PDK4                 0.000000            0.1938161            0.5194187 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.499987            0.8620350            0.2615926 #> GZMB                 0.000000            0.2000420            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X78_Y-73..Fibroblast X77_Y-73..Fibroblast X74_Y-73..Fibroblast #> PDK4                0.6708513            0.0000000                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.5604280            1.2609781                    0 #> GZMB                0.7995518            0.5256183                    0 #> TSC2                0.5604280            0.0000000                    0 #>          X77_Y-74..Fibroblast X75_Y-74..Fibroblast X72_Y-74..Fibroblast #> PDK4                0.1723725            0.2874667            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.6691700            0.4417622            0.0000000 #> GZMB                0.2489771            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.4743751 #>          X74_Y-74..Fibroblast X76_Y-74..Fibroblast X73_Y-74..Fibroblast #> PDK4                0.4957918            0.0000000            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.2827174            0.9081593            0.4782185 #> GZMB                0.0000000            0.3378975            0.0000000 #> TSC2                0.0000000            0.0000000            0.4216667 #>          X78_Y-74..Fibroblast X74_Y-75..Fibroblast X75_Y-75..Fibroblast #> PDK4                        0             0.000000            0.6768172 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             1.022955            0.5890163 #> GZMB                        0             0.000000            0.0000000 #> TSC2                        0             0.000000            0.0000000 #>          X76_Y-75..Fibroblast X77_Y-75..Fibroblast X73_Y-75..Fibroblast #> PDK4                0.6614298            0.3485247             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.2812211            0.3577688             1.490436 #> GZMB                0.0000000            0.2892079             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X75_Y-76..Fibroblast X74_Y-76..Fibroblast X73_Y-76..Fibroblast #> PDK4                0.1847507            0.3341206            0.2290478 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.3106980            0.0000000            0.7092829 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.1975823            0.0000000            0.0000000 #>          X76_Y-76..Fibroblast X78_Y-76..Fibroblast X77_Y-76..Fibroblast #> PDK4                0.0000000             0.000000            0.5483143 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.7895619             1.291578            1.0889630 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.0000000 #>          X72_Y-76..Fibroblast X74_Y-77..Fibroblast X73_Y-77..Fibroblast #> PDK4                0.3562965            0.2669971            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.7260711            0.6887145            0.6896522 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X76_Y-77..Fibroblast X75_Y-77..Fibroblast X77_Y-77..Fibroblast #> PDK4                0.4338479              0.00000            0.8224714 #> TNFRSF17            0.0000000              0.00000            0.0000000 #> ICAM3               0.0000000              0.00000            0.0000000 #> FAP                 1.2300615              1.01996            0.0000000 #> GZMB                0.0000000              0.00000            0.0000000 #> TSC2                0.0000000              0.00000            0.0000000 #>          X72_Y-77..Fibroblast X73_Y-78..Fibroblast X76_Y-78..Fibroblast #> PDK4                0.5487294            0.0000000             0.276085 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 1.1515904            0.7121223             1.813943 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X72_Y-78..Fibroblast X78_Y-78..Fibroblast X75_Y-78..Fibroblast #> PDK4                0.3463830             0.000000            0.2493914 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.5435974             1.768868            1.4358002 #> GZMB                0.0000000             0.000000            0.2411640 #> TSC2                0.0000000             0.000000            0.0000000 #>          X74_Y-78..Fibroblast X75_Y-79..Fibroblast X74_Y-79..Fibroblast #> PDK4                 0.000000            0.2241966             0.000000 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  1.354988            1.2478439             1.158515 #> GZMB                 0.000000            0.2067120             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X73_Y-79..Fibroblast X78_Y-72..Fibroblast X73_Y-73..Fibroblast #> PDK4                 0.000000             1.186929                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  1.001044             0.000000                    0 #> GZMB                 0.000000             0.000000                    0 #> TSC2                 0.000000             0.000000                    0 #>          X78_Y-75..Fibroblast X78_Y-77..Fibroblast X61_Y-68..Fibroblast #> PDK4                 0.000000             0.000000            0.6559976 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  0.000000             1.291578            0.0000000 #> GZMB                 1.735247             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X61_Y-69..Fibroblast X62_Y-69..Fibroblast X63_Y-70..Fibroblast #> PDK4                 1.336959             1.185441            0.0000000 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  0.000000             1.006093            0.7149451 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X64_Y-70..Fibroblast X65_Y-71..Fibroblast X62_Y-71..Fibroblast #> PDK4                0.0000000            0.0000000                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.8159799            0.8159799                    0 #> GZMB                0.8159799            0.8159799                    0 #> TSC2                0.5615951            0.5615951                    0 #>          X61_Y-71..Fibroblast X62_Y-72..Fibroblast X65_Y-72..Fibroblast #> PDK4                        0            0.0000000             0.000000 #> TNFRSF17                    0            0.0000000             0.000000 #> ICAM3                       0            0.0000000             0.000000 #> FAP                         0            0.0000000             1.033836 #> GZMB                        0            0.8572902             1.283970 #> TSC2                        0            0.0000000             0.000000 #>          X66_Y-73..Fibroblast X62_Y-70..Fibroblast X60_Y-71..Fibroblast #> PDK4                 1.090199            0.0000000            0.8889342 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.110762            0.8579341            0.0000000 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 1.146465            0.0000000            0.8889342 #>          X64_Y-72..Fibroblast X65_Y-73..Fibroblast X65_Y-74..Fibroblast #> PDK4                 0.000000                    0            0.0000000 #> TNFRSF17             0.000000                    0            0.0000000 #> ICAM3                0.000000                    0            0.0000000 #> FAP                  0.000000                    0            1.5134401 #> GZMB                 1.925955                    0            0.6555059 #> TSC2                 0.000000                    0            0.0000000 #>          X66_Y-76..Fibroblast X63_Y-73..Fibroblast X65_Y-75..Fibroblast #> PDK4                0.0000000                    0              0.00000 #> TNFRSF17            0.0000000                    0              0.00000 #> ICAM3               0.0000000                    0              0.00000 #> FAP                 0.6611277                    0              3.27753 #> GZMB                0.0000000                    0              3.27753 #> TSC2                0.0000000                    0              0.00000 #>          X66_Y-77..Fibroblast X67_Y-77..Fibroblast X67_Y-73..Fibroblast #> PDK4                0.0000000            0.3918173            0.9191032 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.8820762            1.7884370            0.8171265 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.4037114            0.0000000 #>          X68_Y-74..Fibroblast X71_Y-74..Fibroblast X68_Y-75..Fibroblast #> PDK4                0.4610518            0.9293706            1.7642457 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.4610518            0.9293706            0.8068407 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X71_Y-75..Fibroblast X72_Y-75..Fibroblast X69_Y-75..Fibroblast #> PDK4                 1.239161            0.0000000             0.957405 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  2.348485            0.6655943             0.000000 #> GZMB                 0.000000            0.0000000             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X67_Y-75..Fibroblast X70_Y-76..Fibroblast X67_Y-76..Fibroblast #> PDK4                        0            0.9929658                    0 #> TNFRSF17                    0            0.0000000                    0 #> ICAM3                       0            0.0000000                    0 #> FAP                         0            2.2653125                    0 #> GZMB                        0            0.0000000                    0 #> TSC2                        0            0.0000000                    0 #>          X71_Y-76..Fibroblast X68_Y-76..Fibroblast X71_Y-77..Fibroblast #> PDK4                0.9929658                    0             0.000000 #> TNFRSF17            0.0000000                    0             0.000000 #> ICAM3               0.0000000                    0             0.000000 #> FAP                 2.2653125                    0             0.000000 #> GZMB                1.0889305                    0             1.088931 #> TSC2                0.0000000                    0             0.000000 #>          X70_Y-77..Fibroblast X68_Y-77..Fibroblast X69_Y-77..Fibroblast #> PDK4                        0            0.0000000             0.000000 #> TNFRSF17                    0            0.0000000             0.000000 #> ICAM3                       0            0.0000000             0.000000 #> FAP                         0            0.8074227             1.078122 #> GZMB                        0            0.0000000             0.000000 #> TSC2                        0            0.8074227             0.000000 #>          X69_Y-78..Fibroblast X71_Y-78..Fibroblast X72_Y-79..Fibroblast #> PDK4                1.7767548            0.9552118            0.6432827 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.8085913            0.0000000            0.9723609 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X71_Y-79..Fibroblast X68_Y-73..Fibroblast X67_Y-74..Fibroblast #> PDK4                0.6383262             0.000000            0.7659193 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 1.2627589             1.021408            0.0000000 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.0000000 #>          X69_Y-76..Fibroblast X70_Y-79..Fibroblast X58_Y-73..Fibroblast #> PDK4                0.0000000            0.7641694                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.8496005            0.0000000                    0 #> GZMB                0.0000000            0.0000000                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X59_Y-75..Fibroblast X54_Y-76..Fibroblast X58_Y-76..Fibroblast #> PDK4                 1.262634            0.5624530                    0 #> TNFRSF17             0.000000            0.0000000                    0 #> ICAM3                0.000000            0.0000000                    0 #> FAP                  1.794685            0.5915418                    0 #> GZMB                 0.000000            0.0000000                    0 #> TSC2                 0.000000            0.0000000                    0 #>          X59_Y-76..Fibroblast X54_Y-77..Fibroblast X55_Y-78..Fibroblast #> PDK4                        0            0.2748151             0.000000 #> TNFRSF17                    0            0.0000000             0.000000 #> ICAM3                       0            0.0000000             0.000000 #> FAP                         0            0.5624093             1.169525 #> GZMB                        0            0.0000000             0.000000 #> TSC2                        0            0.0000000             0.000000 #>          X56_Y-79..Fibroblast X55_Y-77..Fibroblast X55_Y-79..Fibroblast #> PDK4                0.0000000            0.0000000            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            0.3865539            0.6981117 #> GZMB                0.4689218            0.0000000            0.0000000 #> TSC2                0.4689218            0.0000000            0.0000000 #>          X68_Y-67..Fibroblast X73_Y-67..Fibroblast X69_Y-68..Fibroblast #> PDK4                0.0000000            0.0000000            0.3419437 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.1015223            0.0000000            0.0000000 #> GZMB                0.4109156            0.0000000            0.0000000 #> TSC2                0.0000000            0.9994398            0.0000000 #>          X73_Y-68..Fibroblast X72_Y-68..Fibroblast X73_Y-69..Fibroblast #> PDK4                        0             0.000000            0.0000000 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             1.198748            0.8990608 #> GZMB                        0             0.000000            0.0000000 #> TSC2                        0             0.000000            0.0000000 #>          X69_Y-69..Fibroblast X68_Y-69..Fibroblast X71_Y-69..Fibroblast #> PDK4                1.7455164             1.523264                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 0.4792546             1.188397                    0 #> GZMB                0.0000000             0.000000                    0 #> TSC2                0.0000000             0.000000                    0 #>          X72_Y-70..Fibroblast X68_Y-70..Fibroblast X71_Y-70..Fibroblast #> PDK4                        0              0.00000                    0 #> TNFRSF17                    0              0.00000                    0 #> ICAM3                       0              0.00000                    0 #> FAP                         0              1.11197                    0 #> GZMB                        0              0.00000                    0 #> TSC2                        0              0.00000                    0 #>          X70_Y-70..Fibroblast X67_Y-70..Fibroblast X67_Y-71..Fibroblast #> PDK4                0.6919979            0.8580134            0.8580134 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.6427031            1.0536484            0.0000000 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X72_Y-72..Fibroblast X68_Y-68..Fibroblast X73_Y-70..Fibroblast #> PDK4                0.0000000                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 0.7499805                    0                    0 #> GZMB                0.0000000                    0                    0 #> TSC2                0.0000000                    0                    0 #>          X52_Y-72..Fibroblast X53_Y-73..Fibroblast X52_Y-73..Fibroblast #> PDK4                 0.000000            0.6544894            0.6544894 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.860528            1.1334822            1.2343726 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X50_Y-73..Fibroblast X50_Y-74..Fibroblast X53_Y-74..Fibroblast #> PDK4                 1.538482             1.538482            0.3122011 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  1.987516             1.987516            0.3373107 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X52_Y-74..Fibroblast X53_Y-75..Fibroblast X54_Y-75..Fibroblast #> PDK4                 1.409789            0.3666545            0.8455459 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.393870            1.5966340            1.7962133 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.5043279            0.5673689 #>          X53_Y-76..Fibroblast X48_Y-77..Fibroblast X54_Y-78..Fibroblast #> PDK4                 0.000000            0.4825138             0.000000 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  1.048772            0.8607933             1.094693 #> GZMB                 0.000000            0.0000000             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X48_Y-78..Fibroblast X53_Y-78..Fibroblast X52_Y-78..Fibroblast #> PDK4                0.2193245             0.000000              0.00000 #> TNFRSF17            0.0000000             0.000000              0.00000 #> ICAM3               0.0000000             0.000000              0.00000 #> FAP                 0.7292226             0.000000              1.91481 #> GZMB                0.0000000             2.317563              0.00000 #> TSC2                0.0000000             0.000000              0.00000 #>          X49_Y-78..Fibroblast X50_Y-79..Fibroblast X49_Y-79..Fibroblast #> PDK4                0.0000000             0.000000            0.0000000 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 1.1389010             1.469185            0.7243997 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.6078321             0.531853            0.3868022 #>          X53_Y-79..Fibroblast X51_Y-79..Fibroblast X52_Y-79..Fibroblast #> PDK4                 0.000000            0.6271664            0.9496826 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.000000            2.5092042            0.8274260 #> GZMB                 4.564657            0.0000000            0.6420270 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X50_Y-78..Fibroblast X43_Y-91..Fibroblast X46_Y-91..Fibroblast #> PDK4                0.0000000            0.2806402            0.4966986 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.8983322            1.2302260            2.3778217 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.5318530            0.0000000            0.0000000 #>          X44_Y-91..Fibroblast X43_Y-92..Fibroblast X42_Y-92..Fibroblast #> PDK4                        0             0.000000            0.0000000 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             1.309267            0.3175374 #> GZMB                        0             0.000000            0.0000000 #> TSC2                        0             0.000000            0.0000000 #>          X44_Y-92..Fibroblast X45_Y-92..Fibroblast X42_Y-93..Fibroblast #> PDK4                 1.682221                    0            0.5429468 #> TNFRSF17             0.000000                    0            0.0000000 #> ICAM3                0.000000                    0            0.0000000 #> FAP                  0.000000                    0            0.5938717 #> GZMB                 0.000000                    0            0.0000000 #> TSC2                 0.000000                    0            0.0000000 #>          X48_Y-93..Fibroblast X43_Y-93..Fibroblast X44_Y-93..Fibroblast #> PDK4                0.4936461            0.2273606            0.8144214 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            1.2304108            0.5050297 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.3321904 #>          X47_Y-93..Fibroblast X46_Y-93..Fibroblast X45_Y-93..Fibroblast #> PDK4                 0.000000                    0            0.0000000 #> TNFRSF17             0.000000                    0            0.0000000 #> ICAM3                0.000000                    0            0.0000000 #> FAP                  2.001511                    0            0.3397727 #> GZMB                 0.000000                    0            0.0000000 #> TSC2                 0.000000                    0            0.4798306 #>          X44_Y-94..Fibroblast X43_Y-94..Fibroblast X45_Y-94..Fibroblast #> PDK4                1.2816768            0.0000000            0.3469518 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.3823096            0.7599635            0.0000000 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X42_Y-94..Fibroblast X46_Y-94..Fibroblast X47_Y-94..Fibroblast #> PDK4                0.2497042                    0             0.000000 #> TNFRSF17            0.0000000                    0             0.000000 #> ICAM3               0.0000000                    0             0.000000 #> FAP                 0.5626750                    0             2.405894 #> GZMB                0.0000000                    0             0.000000 #> TSC2                0.2425889                    0             0.000000 #>          X44_Y-95..Fibroblast X46_Y-95..Fibroblast X43_Y-95..Fibroblast #> PDK4                0.2030953             0.000000            0.2176021 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.0000000             2.326301            0.0000000 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.0000000 #>          X47_Y-95..Fibroblast X45_Y-95..Fibroblast X42_Y-95..Fibroblast #> PDK4                0.5379958            0.0000000            0.3648978 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.6014735            0.2833405            0.9037711 #> GZMB                0.3115109            0.0000000            0.0000000 #> TSC2                0.4530305            0.0000000            0.0000000 #>          X47_Y-96..Fibroblast X46_Y-96..Fibroblast X43_Y-96..Fibroblast #> PDK4                0.7081519            0.3234365            0.6271452 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.8011428            0.7081351            0.8351826 #> GZMB                0.2010946            0.0000000            0.0000000 #> TSC2                0.1798499            0.0000000            0.0000000 #>          X44_Y-96..Fibroblast X42_Y-96..Fibroblast X45_Y-96..Fibroblast #> PDK4                0.6519050            0.6850301            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.3642899            0.4009469            0.7690565 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.1663220            0.0000000            0.0000000 #>          X48_Y-96..Fibroblast X47_Y-97..Fibroblast X46_Y-97..Fibroblast #> PDK4                 1.133571            1.6081999            1.8130529 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.000000            0.3561119            0.2333204 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.2333204 #>          X45_Y-97..Fibroblast X43_Y-97..Fibroblast X42_Y-97..Fibroblast #> PDK4                1.2329940            1.1318242            0.2666561 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.3791456            0.7228483            0.2628046 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.3791456            0.0000000            0.3256353 #>          X44_Y-97..Fibroblast X48_Y-97..Fibroblast X44_Y-98..Fibroblast #> PDK4                0.8760606             1.131645            0.0000000 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.1859414             1.329591            0.5860138 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.1663220             0.000000            0.0000000 #>          X42_Y-91..Fibroblast X46_Y-92..Fibroblast X24_Y-73..Fibroblast #> PDK4                0.0000000                    0              0.00000 #> TNFRSF17            0.0000000                    0              0.00000 #> ICAM3               0.0000000                    0              0.00000 #> FAP                 0.7407994                    0              0.00000 #> GZMB                0.3280252                    0              1.03319 #> TSC2                0.0000000                    0              0.00000 #>          X23_Y-73..Fibroblast X22_Y-73..Fibroblast X22_Y-74..Fibroblast #> PDK4                  0.00000             0.000000             0.000000 #> TNFRSF17              0.00000             0.000000             0.000000 #> ICAM3                 0.00000             0.000000             0.000000 #> FAP                   1.17442             1.236559             1.854839 #> GZMB                  0.00000             0.000000             0.000000 #> TSC2                  0.00000             0.000000             0.000000 #>          X23_Y-75..Fibroblast X22_Y-76..Fibroblast X24_Y-76..Fibroblast #> PDK4                 2.379753             0.000000                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  0.000000             2.769681                    0 #> GZMB                 0.000000             0.000000                    0 #> TSC2                 0.000000             0.000000                    0 #>          X23_Y-77..Fibroblast X24_Y-77..Fibroblast X21_Y-77..Fibroblast #> PDK4                   2.0486                    0             0.000000 #> TNFRSF17               0.0000                    0             0.000000 #> ICAM3                  0.0000                    0             0.000000 #> FAP                    0.0000                    0             1.587687 #> GZMB                   0.0000                    0             0.000000 #> TSC2                   0.0000                    0             0.000000 #>          X23_Y-78..Fibroblast X22_Y-79..Fibroblast X23_Y-79..Fibroblast #> PDK4                 2.179321            0.9124039            0.5678796 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.000000            0.4727918            0.0000000 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X22_Y-75..Fibroblast X22_Y-77..Fibroblast X26_Y-73..Fibroblast #> PDK4                  1.81748             0.000000            1.3296834 #> TNFRSF17              0.00000             0.000000            0.0000000 #> ICAM3                 0.00000             0.000000            0.0000000 #> FAP                   0.00000             1.587687            0.6351334 #> GZMB                  0.00000             0.000000            0.0000000 #> TSC2                  0.00000             0.000000            0.0000000 #>          X28_Y-73..Fibroblast X26_Y-74..Fibroblast X25_Y-74..Fibroblast #> PDK4                0.0000000            0.0000000             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.8062601            0.8711444             2.062278 #> GZMB                0.9132741            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X24_Y-74..Fibroblast X28_Y-74..Fibroblast X23_Y-74..Fibroblast #> PDK4                 3.729311             0.000000             1.752149 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  4.410381             1.004747             0.000000 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             0.000000 #>          X28_Y-75..Fibroblast X24_Y-75..Fibroblast X29_Y-76..Fibroblast #> PDK4                        0            1.3487761                    0 #> TNFRSF17                    0            0.0000000                    0 #> ICAM3                       0            0.0000000                    0 #> FAP                         0            0.7350635                    0 #> GZMB                        0            0.0000000                    0 #> TSC2                        0            0.0000000                    0 #>          X27_Y-76..Fibroblast X26_Y-76..Fibroblast X28_Y-76..Fibroblast #> PDK4                 0.000000            0.0000000                    0 #> TNFRSF17             0.000000            0.0000000                    0 #> ICAM3                0.000000            0.0000000                    0 #> FAP                  2.265416            0.9721727                    0 #> GZMB                 0.000000            0.0000000                    0 #> TSC2                 0.000000            0.0000000                    0 #>          X29_Y-77..Fibroblast X27_Y-79..Fibroblast X28_Y-72..Fibroblast #> PDK4                        0             1.155549                    0 #> TNFRSF17                    0             0.000000                    0 #> ICAM3                       0             0.000000                    0 #> FAP                         0             0.000000                    0 #> GZMB                        0             0.000000                    0 #> TSC2                        0             0.000000                    0 #>          X25_Y-72..Fibroblast X29_Y-73..Fibroblast X27_Y-73..Fibroblast #> PDK4                  0.00000             0.000000            0.5425815 #> TNFRSF17              0.00000             0.000000            0.0000000 #> ICAM3                 0.00000             0.000000            0.0000000 #> FAP                   0.00000             0.000000            0.4031300 #> GZMB                  1.03319             1.217699            0.0000000 #> TSC2                  0.00000             0.000000            0.0000000 #>          X25_Y-73..Fibroblast X29_Y-74..Fibroblast X27_Y-74..Fibroblast #> PDK4                0.7933533                    0             0.000000 #> TNFRSF17            0.0000000                    0             0.000000 #> ICAM3               0.0000000                    0             0.000000 #> FAP                 0.7786778                    0             1.004747 #> GZMB                0.0000000                    0             0.000000 #> TSC2                0.0000000                    0             0.000000 #>          X26_Y-75..Fibroblast X25_Y-75..Fibroblast X27_Y-75..Fibroblast #> PDK4                0.7985048            1.3487761             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.0000000            0.7350635             1.293243 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X25_Y-76..Fibroblast X28_Y-77..Fibroblast X25_Y-77..Fibroblast #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X25_Y-78..Fibroblast X27_Y-78..Fibroblast X28_Y-78..Fibroblast #> PDK4                        0             0.000000            0.5397357 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             0.000000            1.0974364 #> GZMB                        0             1.812122            0.0000000 #> TSC2                        0             0.000000            0.0000000 #>          X24_Y-78..Fibroblast X28_Y-79..Fibroblast X29_Y-79..Fibroblast #> PDK4                 1.385737            0.8044036            0.4944976 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.000000            0.9458929            0.6537565 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X24_Y-79..Fibroblast X33_Y-66..Fibroblast X30_Y-69..Fibroblast #> PDK4                 1.385737                    0                    0 #> TNFRSF17             0.000000                    0                    0 #> ICAM3                0.000000                    0                    0 #> FAP                  0.000000                    0                    0 #> GZMB                 0.000000                    0                    0 #> TSC2                 0.000000                    0                    0 #>          X34_Y-70..Fibroblast X35_Y-70..Fibroblast X33_Y-71..Fibroblast #> PDK4                0.7002576               0.0000             0.000000 #> TNFRSF17            0.0000000               0.0000             0.000000 #> ICAM3               0.0000000               0.0000             0.000000 #> FAP                 0.0000000               1.3638             1.365733 #> GZMB                0.0000000               0.0000             0.000000 #> TSC2                0.0000000               0.0000             0.000000 #>          X31_Y-72..Fibroblast X34_Y-67..Fibroblast X31_Y-68..Fibroblast #> PDK4                        0             2.609251                    0 #> TNFRSF17                    0             0.000000                    0 #> ICAM3                       0             0.000000                    0 #> FAP                         0             1.159865                    0 #> GZMB                        0             0.000000                    0 #> TSC2                        0             0.000000                    0 #>          X33_Y-68..Fibroblast X32_Y-69..Fibroblast X35_Y-69..Fibroblast #> PDK4                        0                    0            0.7632981 #> TNFRSF17                    0                    0            0.0000000 #> ICAM3                       0                    0            0.0000000 #> FAP                         0                    0            0.0000000 #> GZMB                        0                    0            0.0000000 #> TSC2                        0                    0            0.0000000 #>          X33_Y-69..Fibroblast X34_Y-69..Fibroblast X30_Y-71..Fibroblast #> PDK4                 0.000000             1.654016            0.6752893 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  0.000000             0.000000            0.0000000 #> GZMB                 4.051736             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X34_Y-71..Fibroblast X33_Y-72..Fibroblast X34_Y-72..Fibroblast #> PDK4                        0             2.017612             0.000000 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             0.000000             0.488648 #> GZMB                        0             0.000000             0.000000 #> TSC2                        0             0.000000             0.000000 #>          X30_Y-64..Fibroblast X30_Y-65..Fibroblast X32_Y-65..Fibroblast #> PDK4                 2.231594             1.724760                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  1.061403             0.781791                    0 #> GZMB                 0.000000             0.000000                    0 #> TSC2                 0.000000             0.000000                    0 #>          X30_Y-66..Fibroblast X31_Y-65..Fibroblast X35_Y-79..Fibroblast #> PDK4                 1.139451             1.735677             2.687373 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  0.000000             1.005160             0.000000 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             0.000000 #>          X33_Y-79..Fibroblast X31_Y-80..Fibroblast X32_Y-80..Fibroblast #> PDK4                0.8537074             0.000000                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 0.0000000             3.944159                    0 #> GZMB                0.0000000             0.000000                    0 #> TSC2                0.0000000             0.000000                    0 #>          X30_Y-80..Fibroblast X33_Y-80..Fibroblast X29_Y-80..Fibroblast #> PDK4                0.3806975             0.000000             0.696345 #> TNFRSF17            0.0000000             0.000000             0.000000 #> ICAM3               0.0000000             0.000000             0.000000 #> FAP                 0.0000000             1.369636             0.000000 #> GZMB                0.0000000             0.000000             0.000000 #> TSC2                0.0000000             0.000000             0.000000 #>          X36_Y-80..Fibroblast X32_Y-81..Fibroblast X35_Y-81..Fibroblast #> PDK4                1.2288829             1.138189             1.345496 #> TNFRSF17            0.0000000             0.000000             0.000000 #> ICAM3               0.0000000             0.000000             0.000000 #> FAP                 0.9481744             0.000000             0.000000 #> GZMB                0.0000000             0.000000             0.000000 #> TSC2                0.0000000             0.000000             0.000000 #>          X30_Y-81..Fibroblast X33_Y-81..Fibroblast X34_Y-81..Fibroblast #> PDK4                  0.90416             1.593465            0.0000000 #> TNFRSF17              0.00000             0.000000            0.0000000 #> ICAM3                 0.00000             0.000000            0.0000000 #> FAP                   0.00000             0.000000            0.9994398 #> GZMB                  0.00000             0.000000            0.0000000 #> TSC2                  0.00000             0.000000            0.0000000 #>          X31_Y-81..Fibroblast X36_Y-81..Fibroblast X29_Y-81..Fibroblast #> PDK4                0.0000000            0.7484670            1.2426957 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.8345991            0.8243111            0.5427514 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X34_Y-82..Fibroblast X35_Y-82..Fibroblast X33_Y-82..Fibroblast #> PDK4                0.7339068             1.208952                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 0.6824758             1.102937                    0 #> GZMB                0.0000000             0.000000                    0 #> TSC2                0.0000000             0.000000                    0 #>          X33_Y-83..Fibroblast X35_Y-83..Fibroblast X29_Y-83..Fibroblast #> PDK4                0.0000000             1.212053                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 0.4891536             1.044915                    0 #> GZMB                0.0000000             0.000000                    0 #> TSC2                0.0000000             0.000000                    0 #>          X30_Y-83..Fibroblast X34_Y-83..Fibroblast X35_Y-84..Fibroblast #> PDK4                        0            0.5404817            0.7114356 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.7954389            0.4809906 #> GZMB                        0            0.0000000            0.0000000 #> TSC2                        0            0.0000000            0.0000000 #>          X30_Y-84..Fibroblast X29_Y-84..Fibroblast X34_Y-84..Fibroblast #> PDK4                 1.218173             1.840844            0.2649011 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  0.000000             0.344960            0.5094787 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X32_Y-84..Fibroblast X31_Y-84..Fibroblast X33_Y-84..Fibroblast #> PDK4                0.9342352            0.6840042                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.0000000            0.0000000                    0 #> GZMB                0.2769729            0.3621954                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X31_Y-85..Fibroblast X35_Y-85..Fibroblast X32_Y-85..Fibroblast #> PDK4                0.7410046             0.000000             0.994311 #> TNFRSF17            0.0000000             0.000000             0.000000 #> ICAM3               0.0000000             0.000000             0.000000 #> FAP                 0.0000000             1.329805             0.000000 #> GZMB                0.0000000             0.000000             0.000000 #> TSC2                0.0000000             0.000000             0.000000 #>          X35_Y-80..Fibroblast X34_Y-80..Fibroblast X30_Y-82..Fibroblast #> PDK4                1.7226003            1.6578032             1.771306 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.7434965            0.8217817             0.000000 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X31_Y-83..Fibroblast X32_Y-83..Fibroblast X42_Y-64..Fibroblast #> PDK4                        0                    0            0.6368079 #> TNFRSF17                    0                    0            0.0000000 #> ICAM3                       0                    0            0.0000000 #> FAP                         0                    0            1.8839165 #> GZMB                        0                    0            0.0000000 #> TSC2                        0                    0            0.5248954 #>          X39_Y-64..Fibroblast X41_Y-64..Fibroblast X40_Y-64..Fibroblast #> PDK4                0.0000000             0.000000             0.000000 #> TNFRSF17            0.0000000             0.000000             0.000000 #> ICAM3               0.0000000             0.000000             0.000000 #> FAP                 0.6019819             0.805681             1.824942 #> GZMB                0.6296916             0.000000             0.000000 #> TSC2                0.0000000             0.000000             0.000000 #>          X40_Y-65..Fibroblast X39_Y-65..Fibroblast X41_Y-65..Fibroblast #> PDK4                 0.000000            0.4512675            0.0000000 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  2.298971            0.4514864            0.0000000 #> GZMB                 0.000000            0.4722687            0.0000000 #> TSC2                 0.000000            0.4627420            0.6971418 #>          X42_Y-65..Fibroblast X38_Y-65..Fibroblast X39_Y-66..Fibroblast #> PDK4                0.6368079            0.7220280            0.7220280 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.8104049            0.0000000            0.0000000 #> GZMB                0.0000000            0.7313531            0.7313531 #> TSC2                0.5248954            0.0000000            0.0000000 #>          X40_Y-66..Fibroblast X23_Y-66..Fibroblast X22_Y-66..Fibroblast #> PDK4                        0            0.0000000             0.000000 #> TNFRSF17                    0            0.0000000             0.000000 #> ICAM3                       0            0.0000000             0.000000 #> FAP                         0            0.0000000             0.000000 #> GZMB                        0            0.5804147             1.354301 #> TSC2                        0            0.4689218             0.000000 #>          X22_Y-67..Fibroblast X23_Y-68..Fibroblast X21_Y-68..Fibroblast #> PDK4                        0                    0             0.000000 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             1.148884 #>          X23_Y-70..Fibroblast X22_Y-71..Fibroblast X23_Y-71..Fibroblast #> PDK4                 1.066624               2.0371                    0 #> TNFRSF17             0.000000               0.0000                    0 #> ICAM3                0.000000               0.0000                    0 #> FAP                  1.066624               0.0000                    0 #> GZMB                 0.000000               0.0000                    0 #> TSC2                 0.000000               0.0000                    0 #>          X22_Y-72..Fibroblast X22_Y-68..Fibroblast X22_Y-69..Fibroblast #> PDK4                 4.175964                    0                    0 #> TNFRSF17             0.000000                    0                    0 #> ICAM3                0.000000                    0                    0 #> FAP                  0.000000                    0                    0 #> GZMB                 0.000000                    0                    0 #> TSC2                 0.000000                    0                    0 #>          X24_Y-80..Fibroblast X27_Y-80..Fibroblast X25_Y-80..Fibroblast #> PDK4                0.9784680            0.7434965            0.6375373 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.2801672            0.0000000            0.0000000 #> GZMB                0.2942480            0.0000000            0.6375373 #> TSC2                0.0000000            0.0000000            0.6289972 #>          X23_Y-80..Fibroblast X28_Y-81..Fibroblast X26_Y-81..Fibroblast #> PDK4                0.2924386             0.000000             1.907532 #> TNFRSF17            0.0000000             0.000000             0.000000 #> ICAM3               0.0000000             0.000000             0.000000 #> FAP                 0.0000000             1.626594             0.000000 #> GZMB                0.0000000             0.000000             0.000000 #> TSC2                0.0000000             0.000000             0.000000 #>          X24_Y-82..Fibroblast X28_Y-82..Fibroblast X27_Y-82..Fibroblast #> PDK4                        0            1.8159554             3.043831 #> TNFRSF17                    0            0.0000000             0.000000 #> ICAM3                       0            0.0000000             0.000000 #> FAP                         0            0.5414235             0.000000 #> GZMB                        0            0.0000000             0.000000 #> TSC2                        0            0.0000000             0.000000 #>          X29_Y-82..Fibroblast X26_Y-82..Fibroblast X26_Y-83..Fibroblast #> PDK4                 1.043203             1.400111            0.3535173 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  0.000000             0.000000            0.3535173 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X24_Y-83..Fibroblast X25_Y-83..Fibroblast X28_Y-84..Fibroblast #> PDK4                        0                    0             1.218351 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.313600 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X25_Y-84..Fibroblast X25_Y-79..Fibroblast X26_Y-79..Fibroblast #> PDK4                0.5321931             1.385737            0.7284347 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.6294819             0.000000            0.7624308 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.0000000 #>          X26_Y-80..Fibroblast X28_Y-80..Fibroblast X23_Y-81..Fibroblast #> PDK4                0.7863651                    0             1.109451 #> TNFRSF17            0.0000000                    0             0.000000 #> ICAM3               0.0000000                    0             0.000000 #> FAP                 0.0000000                    0             0.000000 #> GZMB                0.0000000                    0             0.000000 #> TSC2                0.0000000                    0             0.000000 #>          X25_Y-81..Fibroblast X25_Y-82..Fibroblast X27_Y-83..Fibroblast #> PDK4                 0.000000             1.137039             1.166727 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  2.274077             1.104611             0.000000 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             0.000000 #>          X28_Y-83..Fibroblast X26_Y-84..Fibroblast X24_Y-84..Fibroblast #> PDK4                 1.223454            0.5555272                    0 #> TNFRSF17             0.000000            0.0000000                    0 #> ICAM3                0.000000            0.0000000                    0 #> FAP                  0.000000            0.5555272                    0 #> GZMB                 0.000000            0.0000000                    0 #> TSC2                 0.000000            0.0000000                    0 #>          X29_Y-85..Fibroblast X25_Y-85..Fibroblast X26_Y-85..Fibroblast #> PDK4                 2.001998             1.241784                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  0.492800             1.468791                    0 #> GZMB                 0.000000             0.000000                    0 #> TSC2                 0.000000             0.000000                    0 #>          X23_Y-85..Fibroblast X24_Y-66..Fibroblast X25_Y-66..Fibroblast #> PDK4                 1.536727            0.0000000            0.0000000 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.000000            0.6233351            0.4848162 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X29_Y-66..Fibroblast X28_Y-67..Fibroblast X24_Y-67..Fibroblast #> PDK4                1.3293598             1.371343             0.000000 #> TNFRSF17            0.0000000             0.000000             0.000000 #> ICAM3               0.0000000             0.000000             0.000000 #> FAP                 0.0000000             0.000000             1.940315 #> GZMB                0.5371206             0.000000             0.000000 #> TSC2                0.0000000             0.000000             0.000000 #>          X30_Y-67..Fibroblast X25_Y-67..Fibroblast X26_Y-67..Fibroblast #> PDK4                  0.98542            0.0000000             0.000000 #> TNFRSF17              0.00000            0.0000000             0.000000 #> ICAM3                 0.00000            0.0000000             0.000000 #> FAP                   0.98542            0.4848162             1.248885 #> GZMB                  0.00000            0.0000000             0.000000 #> TSC2                  0.00000            0.0000000             0.000000 #>          X27_Y-67..Fibroblast X29_Y-67..Fibroblast X24_Y-68..Fibroblast #> PDK4                0.7650447             1.279491             0.000000 #> TNFRSF17            0.0000000             0.000000             0.000000 #> ICAM3               0.0000000             0.000000             0.000000 #> FAP                 0.7098303             1.262179             1.132639 #> GZMB                0.0000000             0.000000             0.000000 #> TSC2                0.0000000             0.000000             0.000000 #>          X25_Y-68..Fibroblast X28_Y-68..Fibroblast X27_Y-68..Fibroblast #> PDK4                 1.187456            0.6676793            0.9187379 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.159865            0.7458622            0.9628370 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X30_Y-68..Fibroblast X26_Y-69..Fibroblast X25_Y-69..Fibroblast #> PDK4                        0             1.036915              1.75092 #> TNFRSF17                    0             0.000000              0.00000 #> ICAM3                       0             0.000000              0.00000 #> FAP                         0             1.055035              0.00000 #> GZMB                        0             0.000000              0.00000 #> TSC2                        0             0.000000              0.00000 #>          X27_Y-69..Fibroblast X23_Y-69..Fibroblast X29_Y-69..Fibroblast #> PDK4                0.8809836                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 1.0006116                    0                    0 #> GZMB                0.0000000                    0                    0 #> TSC2                0.0000000                    0                    0 #>          X24_Y-69..Fibroblast X29_Y-70..Fibroblast X24_Y-70..Fibroblast #> PDK4                0.7999682                    0             1.066624 #> TNFRSF17            0.0000000                    0             0.000000 #> ICAM3               0.0000000                    0             0.000000 #> FAP                 0.7999682                    0             1.066624 #> GZMB                0.0000000                    0             0.000000 #> TSC2                0.0000000                    0             0.000000 #>          X26_Y-70..Fibroblast X25_Y-70..Fibroblast X27_Y-70..Fibroblast #> PDK4                 0.762025             1.035190             3.389573 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  0.760433             1.018674             0.000000 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             0.000000 #>          X25_Y-71..Fibroblast X26_Y-71..Fibroblast X29_Y-71..Fibroblast #> PDK4                0.4103065                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 0.0000000                    0                    0 #> GZMB                0.0000000                    0                    0 #> TSC2                0.0000000                    0                    0 #>          X28_Y-71..Fibroblast X26_Y-72..Fibroblast X23_Y-72..Fibroblast #> PDK4                        0                    0             4.068535 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X26_Y-68..Fibroblast X29_Y-68..Fibroblast X27_Y-71..Fibroblast #> PDK4                0.8261650             0.000000                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 0.8325901             1.262179                    0 #> GZMB                0.0000000             0.000000                    0 #> TSC2                0.0000000             0.000000                    0 #>          X24_Y-71..Fibroblast X29_Y-72..Fibroblast X27_Y-72..Fibroblast #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X24_Y-72..Fibroblast X22_Y-80..Fibroblast X22_Y-82..Fibroblast #> PDK4                  0.00000              0.39878             1.248121 #> TNFRSF17              0.00000              0.00000             0.000000 #> ICAM3                 0.00000              0.00000             0.000000 #> FAP                   0.00000              0.00000             0.000000 #> GZMB                  1.03319              0.00000             0.000000 #> TSC2                  0.00000              0.00000             0.000000 #>          X22_Y-83..Fibroblast X23_Y-83..Fibroblast X22_Y-84..Fibroblast #> PDK4                 1.012995            0.7580258            0.4221184 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.000000            0.5640087            0.0000000 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X23_Y-84..Fibroblast X22_Y-85..Fibroblast X22_Y-81..Fibroblast #> PDK4                0.5276480            0.3568834            0.9755592 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.4230065            0.3026146            0.0000000 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.3829597            0.0000000 #>          X24_Y-81..Fibroblast X21_Y-82..Fibroblast X23_Y-82..Fibroblast #> PDK4                 2.199402             1.132553            0.6296916 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  0.000000             0.000000            0.0000000 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X44_Y-64..Fibroblast X47_Y-64..Fibroblast X46_Y-64..Fibroblast #> PDK4                0.7580665            0.0000000            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.5262313            0.7903272            0.5136136 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X43_Y-64..Fibroblast X45_Y-65..Fibroblast X44_Y-65..Fibroblast #> PDK4                0.7732440            0.3578855            0.6317221 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.7876392            1.0385240            0.6357011 #> GZMB                0.3907623            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X46_Y-65..Fibroblast X43_Y-65..Fibroblast X47_Y-65..Fibroblast #> PDK4                0.0000000            1.0801985            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.3160699            1.0105610            0.9364976 #> GZMB                0.0000000            0.2605082            0.0000000 #> TSC2                0.0000000            0.2099582            0.0000000 #>          X43_Y-66..Fibroblast X47_Y-66..Fibroblast X44_Y-66..Fibroblast #> PDK4                0.8591371              0.00000            0.0000000 #> TNFRSF17            0.0000000              0.00000            0.0000000 #> ICAM3               0.0000000              0.00000            0.0000000 #> FAP                 0.4348158              1.24634            0.5379577 #> GZMB                0.0000000              0.00000            0.0000000 #> TSC2                0.0000000              0.00000            0.0000000 #>          X46_Y-66..Fibroblast X45_Y-66..Fibroblast X44_Y-67..Fibroblast #> PDK4                0.3965608            0.4274901            0.9303529 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.3386482            0.4184115            1.7826211 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.3398804 #>          X46_Y-67..Fibroblast X47_Y-67..Fibroblast X52_Y-64..Fibroblast #> PDK4                0.0000000             0.533897            0.5764164 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.5741413             1.562191            1.3862538 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.0000000 #>          X49_Y-64..Fibroblast X51_Y-65..Fibroblast X52_Y-65..Fibroblast #> PDK4                 1.031144             0.000000            0.3144089 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  1.031144             1.039507            0.6548764 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X50_Y-65..Fibroblast X48_Y-65..Fibroblast X53_Y-65..Fibroblast #> PDK4                0.0000000             1.656912             1.326253 #> TNFRSF17            0.0000000             0.000000             0.000000 #> ICAM3               0.0000000             0.000000             0.000000 #> FAP                 0.3157744             0.000000             0.916307 #> GZMB                0.0000000             0.000000             0.000000 #> TSC2                0.0000000             0.000000             0.000000 #>          X54_Y-65..Fibroblast X49_Y-65..Fibroblast X52_Y-66..Fibroblast #> PDK4                0.8345991            0.3093432             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.0000000            0.3093432             1.037702 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X49_Y-66..Fibroblast X48_Y-66..Fibroblast X50_Y-66..Fibroblast #> PDK4                0.4317633                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 0.4838064                    0                    0 #> GZMB                0.0000000                    0                    0 #> TSC2                0.0000000                    0                    0 #>          X51_Y-66..Fibroblast X52_Y-67..Fibroblast X53_Y-67..Fibroblast #> PDK4                0.0000000            1.0051299            0.7466574 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.6359561            0.0000000            0.0000000 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.6039742            0.5448505 #>          X53_Y-64..Fibroblast X51_Y-64..Fibroblast X51_Y-67..Fibroblast #> PDK4                0.7496016             0.000000             0.000000 #> TNFRSF17            0.0000000             0.000000             0.000000 #> ICAM3               0.0000000             0.000000             0.000000 #> FAP                 0.8320623             1.383324             0.410049 #> GZMB                0.0000000             0.000000             0.000000 #> TSC2                0.0000000             0.000000             0.000000 #>          X41_Y-79..Fibroblast X40_Y-79..Fibroblast X38_Y-80..Fibroblast #> PDK4                0.3289886              0.00000             1.377566 #> TNFRSF17            0.0000000              0.00000             0.000000 #> ICAM3               0.0000000              0.00000             0.000000 #> FAP                 0.2633319              1.64867             1.792074 #> GZMB                0.0000000              0.00000             0.000000 #> TSC2                0.3455523              0.00000             0.000000 #>          X40_Y-80..Fibroblast X41_Y-80..Fibroblast X39_Y-80..Fibroblast #> PDK4                 0.000000                    0             0.259348 #> TNFRSF17             0.000000                    0             0.000000 #> ICAM3                0.000000                    0             0.000000 #> FAP                  1.438465                    0             1.441472 #> GZMB                 0.000000                    0             0.000000 #> TSC2                 0.000000                    0             0.000000 #>          X37_Y-80..Fibroblast X42_Y-80..Fibroblast X37_Y-81..Fibroblast #> PDK4                0.8687486            0.1935227            0.6915246 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.7612093            0.9632688            1.1761266 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X40_Y-81..Fibroblast X39_Y-81..Fibroblast X41_Y-81..Fibroblast #> PDK4                 0.253820            0.2937381             1.541691 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  1.295492            2.0391246             1.262179 #> GZMB                 0.000000            0.2653506             0.000000 #> TSC2                 0.000000            0.2581217             0.000000 #>          X38_Y-81..Fibroblast X42_Y-81..Fibroblast X36_Y-82..Fibroblast #> PDK4                0.4406072            0.0000000            0.5117925 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 2.3976111            0.4207264            1.0305603 #> GZMB                0.3980260            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X40_Y-82..Fibroblast X42_Y-82..Fibroblast X39_Y-82..Fibroblast #> PDK4                0.4371422             0.000000            0.2349905 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 2.0256344             1.267326            2.0707749 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.2064974 #>          X38_Y-82..Fibroblast X41_Y-82..Fibroblast X41_Y-83..Fibroblast #> PDK4                0.7220567            0.3851911            0.2751365 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.3666545            1.9823763            1.6735935 #> GZMB                0.3932621            0.2989107            0.2135076 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X39_Y-83..Fibroblast X38_Y-83..Fibroblast X42_Y-83..Fibroblast #> PDK4                0.2646758            1.0090482            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 2.2888207            1.7089541            1.3753620 #> GZMB                0.0000000            0.5056226            0.3736383 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X40_Y-83..Fibroblast X36_Y-83..Fibroblast X37_Y-83..Fibroblast #> PDK4                 0.000000             0.000000            0.0000000 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  2.201626             1.665985            0.8919597 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X41_Y-84..Fibroblast X40_Y-84..Fibroblast X38_Y-84..Fibroblast #> PDK4                0.8233924             1.567083            0.4939545 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 1.2913438             3.192131            1.3150745 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.0000000 #>          X39_Y-84..Fibroblast X36_Y-84..Fibroblast X37_Y-84..Fibroblast #> PDK4                0.4988378            0.6335396            0.4083696 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 2.0696051            1.7824101            0.4300138 #> GZMB                0.0000000            0.0000000            0.4720003 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X42_Y-84..Fibroblast X41_Y-85..Fibroblast X37_Y-85..Fibroblast #> PDK4                  0.00000            0.8264151            0.5981383 #> TNFRSF17              0.00000            0.0000000            0.0000000 #> ICAM3                 0.00000            0.0000000            0.0000000 #> FAP                   1.07378            0.2561395            0.2570016 #> GZMB                  0.00000            0.0000000            0.6802706 #> TSC2                  0.00000            0.3024643            0.0000000 #>          X42_Y-85..Fibroblast X37_Y-82..Fibroblast X43_Y-72..Fibroblast #> PDK4                0.0000000                    0            0.0000000 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.9767333                    0            0.6671705 #> GZMB                0.6470585                    0            0.6671705 #> TSC2                0.0000000                    0            0.0000000 #>          X44_Y-72..Fibroblast X45_Y-72..Fibroblast X47_Y-72..Fibroblast #> PDK4                0.6678182            0.0000000            0.4776647 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.7593707            1.1830031            0.4115948 #> GZMB                0.3434955            0.3816617            0.4776647 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X43_Y-73..Fibroblast X46_Y-73..Fibroblast X47_Y-73..Fibroblast #> PDK4                0.6506650             0.000000            0.0000000 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.6472455             1.857276            1.5140215 #> GZMB                0.0000000             0.000000            0.4477732 #> TSC2                0.0000000             0.000000            0.0000000 #>          X45_Y-73..Fibroblast X44_Y-73..Fibroblast X44_Y-74..Fibroblast #> PDK4                0.2091433            0.8013707                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.7333962            0.4576566                    0 #> GZMB                0.0000000            0.0000000                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X46_Y-74..Fibroblast X45_Y-74..Fibroblast X43_Y-74..Fibroblast #> PDK4                 0.000000                    0                    0 #> TNFRSF17             0.000000                    0                    0 #> ICAM3                0.000000                    0                    0 #> FAP                  1.078527                    0                    0 #> GZMB                 0.000000                    0                    0 #> TSC2                 0.000000                    0                    0 #>          X47_Y-74..Fibroblast X47_Y-75..Fibroblast X46_Y-75..Fibroblast #> PDK4                 0.000000            0.3214652            0.3613623 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.147189            1.0291937            0.5519578 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X43_Y-75..Fibroblast X44_Y-75..Fibroblast X45_Y-75..Fibroblast #> PDK4                0.5769138            0.4060663                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.5462550            0.5251932                    0 #> GZMB                0.0000000            0.5379958                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X43_Y-76..Fibroblast X47_Y-76..Fibroblast X46_Y-76..Fibroblast #> PDK4                0.4896539            0.2611975                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.9694632            1.1113564                    0 #> GZMB                0.5379958            0.0000000                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X42_Y-76..Fibroblast X44_Y-76..Fibroblast X45_Y-76..Fibroblast #> PDK4                0.4081616            0.4896539             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.8984974            0.9906933             1.195406 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X43_Y-77..Fibroblast X45_Y-77..Fibroblast X44_Y-77..Fibroblast #> PDK4                0.2538053            1.1513173             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 1.3423831            0.0000000             1.174443 #> GZMB                0.0000000            0.8224714             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X47_Y-77..Fibroblast X46_Y-77..Fibroblast X43_Y-78..Fibroblast #> PDK4                0.0000000            0.9210538            0.9921349 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.8226771            0.0000000            1.0739523 #> GZMB                0.0000000            0.6579771            0.4557993 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X44_Y-78..Fibroblast X45_Y-78..Fibroblast X47_Y-78..Fibroblast #> PDK4                0.2307321             0.000000                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 1.0280887             1.631446                    0 #> GZMB                0.0000000             0.000000                    0 #> TSC2                0.0000000             0.000000                    0 #>          X44_Y-79..Fibroblast X47_Y-79..Fibroblast X48_Y-79..Fibroblast #> PDK4                 0.000000             0.467661             0.000000 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  1.415009             0.467661             1.216489 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             0.000000 #>          X46_Y-78..Fibroblast X46_Y-79..Fibroblast X76_Y-79..Fibroblast #> PDK4                 0.000000                    0            0.0000000 #> TNFRSF17             0.000000                    0            0.0000000 #> ICAM3                0.000000                    0            0.0000000 #> FAP                  2.412181                    0            0.9229708 #> GZMB                 0.000000                    0            0.0000000 #> TSC2                 0.000000                    0            0.0000000 #>          X78_Y-79..Fibroblast X77_Y-79..Fibroblast X74_Y-80..Fibroblast #> PDK4                0.0000000                    0            0.0000000 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.7475007                    0            0.5882777 #> GZMB                0.0000000                    0            0.0000000 #> TSC2                0.0000000                    0            0.0000000 #>          X76_Y-80..Fibroblast X73_Y-80..Fibroblast X72_Y-80..Fibroblast #> PDK4                        0            0.1592764            0.2865655 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.7607485            0.8328076 #> GZMB                        0            0.0000000            0.0000000 #> TSC2                        0            0.0000000            0.0000000 #>          X75_Y-80..Fibroblast X74_Y-81..Fibroblast X73_Y-81..Fibroblast #> PDK4                 0.392344                    0            0.1686456 #> TNFRSF17             0.000000                    0            0.0000000 #> ICAM3                0.000000                    0            0.0000000 #> FAP                  0.000000                    0            0.1686456 #> GZMB                 0.000000                    0            0.0000000 #> TSC2                 0.000000                    0            0.0000000 #>          X77_Y-81..Fibroblast X75_Y-81..Fibroblast X72_Y-81..Fibroblast #> PDK4                0.0000000            0.0000000            0.2866975 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.9721727            0.8940675            1.0277466 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X76_Y-81..Fibroblast X73_Y-82..Fibroblast X76_Y-82..Fibroblast #> PDK4                0.5310003            0.1852899            0.7080004 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.0760226            1.0010110            0.0000000 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X74_Y-82..Fibroblast X75_Y-82..Fibroblast X78_Y-82..Fibroblast #> PDK4                0.5154553            0.7080004             1.658831 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 1.1604682            0.0000000             1.996262 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             1.658831 #>          X77_Y-82..Fibroblast X78_Y-83..Fibroblast X74_Y-83..Fibroblast #> PDK4                0.5529436             1.538687            0.0000000 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 1.3285375             0.000000            0.5884619 #> GZMB                0.4861375             0.000000            0.0000000 #> TSC2                1.3019751             0.000000            0.0000000 #>          X77_Y-83..Fibroblast X76_Y-83..Fibroblast X75_Y-83..Fibroblast #> PDK4                0.0000000            0.4822616            0.6751663 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.3617001            0.0000000            0.6525834 #> GZMB                0.2651659            0.0000000            0.0000000 #> TSC2                0.3247640            0.0000000            0.0000000 #>          X73_Y-83..Fibroblast X79_Y-83..Fibroblast X76_Y-84..Fibroblast #> PDK4                0.0000000             2.308031            0.0000000 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.8422332             0.000000            0.4724534 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.0000000 #>          X78_Y-84..Fibroblast X73_Y-84..Fibroblast X74_Y-84..Fibroblast #> PDK4                0.9226102                    0            0.0000000 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.0000000                    0            0.6812148 #> GZMB                0.0000000                    0            0.3119940 #> TSC2                0.0000000                    0            0.0000000 #>          X75_Y-84..Fibroblast X77_Y-84..Fibroblast X79_Y-85..Fibroblast #> PDK4                0.0000000            0.7380881                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.8099696            0.0000000                    0 #> GZMB                0.4921267            0.0000000                    0 #> TSC2                0.2692739            0.0000000                    0 #>          X72_Y-83..Fibroblast X79_Y-65..Fibroblast X74_Y-66..Fibroblast #> PDK4                0.0000000             0.000000            0.2634519 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.4610926             0.606633            0.7370671 #> GZMB                0.0000000             0.000000            0.4057303 #> TSC2                0.0000000             0.000000            0.5627217 #>          X76_Y-66..Fibroblast X75_Y-67..Fibroblast X74_Y-67..Fibroblast #> PDK4                0.0000000            0.6582026             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.0000000            0.9652139             1.901131 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.5266638            0.0000000             0.000000 #>          X79_Y-67..Fibroblast X76_Y-67..Fibroblast X77_Y-67..Fibroblast #> PDK4                        0            0.5941368            0.0000000 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            1.2576799            0.7490756 #> GZMB                        0            0.0000000            0.7490756 #> TSC2                        0            0.0000000            0.0000000 #>          X75_Y-68..Fibroblast X78_Y-68..Fibroblast X77_Y-68..Fibroblast #> PDK4                1.2099225                    0            0.0000000 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.6025548                    0            0.2496919 #> GZMB                0.0000000                    0            0.2496919 #> TSC2                0.0000000                    0            0.3459200 #>          X76_Y-68..Fibroblast X77_Y-69..Fibroblast X74_Y-69..Fibroblast #> PDK4                0.6665598            0.0000000                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.4548868            0.3001104                    0 #> GZMB                0.0000000            0.0000000                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X78_Y-69..Fibroblast X75_Y-69..Fibroblast X76_Y-69..Fibroblast #> PDK4                0.4494522            0.0000000            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.2011935            0.9735436            0.2596922 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X79_Y-69..Fibroblast X76_Y-70..Fibroblast X77_Y-70..Fibroblast #> PDK4                0.5842879                    0            0.4439043 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.2615516                    0            0.1716986 #> GZMB                0.0000000                    0            0.0000000 #> TSC2                0.0000000                    0            0.0000000 #>          X78_Y-70..Fibroblast X77_Y-71..Fibroblast X76_Y-71..Fibroblast #> PDK4                0.2305259            0.5463438            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.7690042            0.5321792            0.5727936 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X78_Y-71..Fibroblast X73_Y-71..Fibroblast X74_Y-71..Fibroblast #> PDK4                0.8901965             0.000000               0.0000 #> TNFRSF17            0.0000000             0.000000               0.0000 #> ICAM3               0.0000000             0.000000               0.0000 #> FAP                 0.4679124             1.365733               2.0486 #> GZMB                0.0000000             0.000000               0.0000 #> TSC2                0.0000000             0.000000               0.0000 #>          X74_Y-72..Fibroblast X75_Y-72..Fibroblast X76_Y-72..Fibroblast #> PDK4                        0            0.2196583            0.0000000 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.4769440            0.2838801 #> GZMB                        0            0.0000000            0.3662093 #> TSC2                        0            0.0000000            0.0000000 #>          X74_Y-68..Fibroblast X56_Y-67..Fibroblast X58_Y-67..Fibroblast #> PDK4                        0              0.00000             0.000000 #> TNFRSF17                    0              0.00000             0.000000 #> ICAM3                       0              0.00000             0.000000 #> FAP                         0              0.00000             1.148884 #> GZMB                        0              0.39886             0.000000 #> TSC2                        0              0.00000             0.000000 #>          X57_Y-67..Fibroblast X60_Y-67..Fibroblast X60_Y-68..Fibroblast #> PDK4                        0            0.0000000            0.0000000 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.9393739            0.7514991 #> GZMB                        0            0.0000000            0.0000000 #> TSC2                        0            0.0000000            0.0000000 #>          X57_Y-68..Fibroblast X58_Y-68..Fibroblast X58_Y-69..Fibroblast #> PDK4                        0            0.0000000            0.0000000 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.9757137            0.9757137 #> GZMB                        0            0.0000000            0.0000000 #> TSC2                        0            0.0000000            0.0000000 #>          X59_Y-70..Fibroblast X60_Y-70..Fibroblast X56_Y-66..Fibroblast #> PDK4                        0            0.8889342             0.000000 #> TNFRSF17                    0            0.0000000             0.000000 #> ICAM3                       0            0.0000000             0.000000 #> FAP                         0            0.0000000             1.132609 #> GZMB                        0            0.0000000             0.000000 #> TSC2                        0            0.8889342             0.000000 #>          X43_Y-79..Fibroblast X47_Y-80..Fibroblast X43_Y-80..Fibroblast #> PDK4                0.2997809             0.000000             0.000000 #> TNFRSF17            0.0000000             0.000000             0.000000 #> ICAM3               0.0000000             0.000000             0.000000 #> FAP                 1.6105204             1.342435             1.809807 #> GZMB                0.6583767             0.000000             0.000000 #> TSC2                0.0000000             0.000000             0.000000 #>          X44_Y-80..Fibroblast X48_Y-80..Fibroblast X46_Y-80..Fibroblast #> PDK4                 0.000000            0.2515534             0.000000 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  2.246676            1.6329134             1.083301 #> GZMB                 0.000000            0.0000000             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X47_Y-81..Fibroblast X45_Y-81..Fibroblast X46_Y-81..Fibroblast #> PDK4                        0            0.7308661             1.461732 #> TNFRSF17                    0            0.0000000             0.000000 #> ICAM3                       0            0.0000000             0.000000 #> FAP                         0            0.0000000             0.000000 #> GZMB                        0            0.0000000             0.000000 #> TSC2                        0            0.0000000             0.000000 #>          X44_Y-81..Fibroblast X45_Y-82..Fibroblast X44_Y-82..Fibroblast #> PDK4                 0.000000                    0            0.6032782 #> TNFRSF17             0.000000                    0            0.0000000 #> ICAM3                0.000000                    0            0.0000000 #> FAP                  3.362905                    0            0.8148402 #> GZMB                 0.000000                    0            0.0000000 #> TSC2                 0.000000                    0            0.0000000 #>          X46_Y-82..Fibroblast X43_Y-82..Fibroblast X46_Y-83..Fibroblast #> PDK4                0.0000000                    0            0.3729684 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.7389220                    0            0.8962852 #> GZMB                0.9178963                    0            0.4589481 #> TSC2                0.0000000                    0            0.0000000 #>          X44_Y-83..Fibroblast X45_Y-83..Fibroblast X43_Y-83..Fibroblast #> PDK4                0.5617966            1.9109444             0.949815 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.9993157            0.6404887             0.000000 #> GZMB                0.0000000            0.4975883             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X43_Y-84..Fibroblast X44_Y-84..Fibroblast X45_Y-84..Fibroblast #> PDK4                0.7697237            0.3151367            0.9268462 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.5225678            0.3718103            0.0000000 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X45_Y-85..Fibroblast X44_Y-85..Fibroblast X51_Y-91..Fibroblast #> PDK4                0.3528194            0.0000000            0.7762752 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.4269925            0.8986848            1.1796943 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X53_Y-91..Fibroblast X49_Y-91..Fibroblast X50_Y-91..Fibroblast #> PDK4                0.5439129             0.000000            0.8662256 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.7725544             1.872375            1.0591172 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.3419928             0.000000            0.0000000 #>          X52_Y-91..Fibroblast X51_Y-92..Fibroblast X50_Y-92..Fibroblast #> PDK4                0.4462001            0.2999502            0.7672848 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.9567266            0.4448220            0.4777005 #> GZMB                0.2232353            0.4448220            0.2516743 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X53_Y-92..Fibroblast X52_Y-92..Fibroblast X49_Y-92..Fibroblast #> PDK4                0.3973663            0.4371029            2.4078075 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.6464128            0.6692002            0.5936471 #> GZMB                0.0000000            0.0000000            0.7550230 #> TSC2                0.2672982            0.0000000            0.0000000 #>          X52_Y-93..Fibroblast X53_Y-93..Fibroblast X51_Y-93..Fibroblast #> PDK4                0.8267396            0.0000000            0.5610106 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.3560442            2.5453356            0.0000000 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.4900467            0.6916996 #>          X54_Y-93..Fibroblast X51_Y-94..Fibroblast X53_Y-94..Fibroblast #> PDK4                 0.723492            0.7012632            0.9585093 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.040855            0.0000000            1.5935985 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.8646246            0.0000000 #>          X50_Y-94..Fibroblast X49_Y-94..Fibroblast X48_Y-95..Fibroblast #> PDK4                        0                    0            1.0759916 #> TNFRSF17                    0                    0            0.0000000 #> ICAM3                       0                    0            0.0000000 #> FAP                         0                    0            0.0000000 #> GZMB                        0                    0            0.0000000 #> TSC2                        0                    0            0.9060609 #>          X52_Y-96..Fibroblast X51_Y-96..Fibroblast X50_Y-96..Fibroblast #> PDK4                0.0000000            0.0000000             1.806465 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.5220731            0.5220731             1.060307 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X53_Y-96..Fibroblast X54_Y-96..Fibroblast X49_Y-96..Fibroblast #> PDK4                0.0000000             0.000000                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 0.9454101             2.724253                    0 #> GZMB                0.0000000             0.000000                    0 #> TSC2                0.0000000             0.000000                    0 #>          X53_Y-97..Fibroblast X52_Y-98..Fibroblast X49_Y-93..Fibroblast #> PDK4                 0.000000              0.00000             1.819280 #> TNFRSF17             0.000000              0.00000             0.000000 #> ICAM3                0.000000              0.00000             0.000000 #> FAP                  1.390121              1.99372             1.187294 #> GZMB                 0.000000              0.00000             1.510046 #> TSC2                 0.000000              0.00000             0.000000 #>          X71_Y-80..Fibroblast X71_Y-81..Fibroblast X71_Y-82..Fibroblast #> PDK4                 1.117071                    0            0.6762172 #> TNFRSF17             0.000000                    0            0.0000000 #> ICAM3                0.000000                    0            0.0000000 #> FAP                  1.117071                    0            0.0000000 #> GZMB                 0.000000                    0            0.0000000 #> TSC2                 0.000000                    0            0.0000000 #>          X67_Y-82..Fibroblast X71_Y-83..Fibroblast X67_Y-83..Fibroblast #> PDK4                        0            0.2704869                    0 #> TNFRSF17                    0            0.0000000                    0 #> ICAM3                       0            0.0000000                    0 #> FAP                         0            0.5014579                    0 #> GZMB                        0            0.0000000                    0 #> TSC2                        0            0.0000000                    0 #>          X70_Y-83..Fibroblast X69_Y-83..Fibroblast X69_Y-84..Fibroblast #> PDK4                0.0000000            0.4371271            1.3166299 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.6536786            0.5602959            0.0000000 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.5715268            1.0081376            0.7255605 #>          X71_Y-84..Fibroblast X67_Y-84..Fibroblast X68_Y-84..Fibroblast #> PDK4                 0.000000            0.0000000            0.5033228 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.092384            1.1080904            1.2522554 #> GZMB                 0.000000            0.5992981            0.0000000 #> TSC2                 0.000000            0.0000000            0.5589164 #>          X72_Y-84..Fibroblast X72_Y-85..Fibroblast X67_Y-85..Fibroblast #> PDK4                0.0000000            0.0000000            0.8432767 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.5077125            0.2976158            0.8432767 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X71_Y-85..Fibroblast X68_Y-85..Fibroblast X72_Y-82..Fibroblast #> PDK4                0.0000000             0.000000                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 0.6422503             2.921929                    0 #> GZMB                0.0000000             0.000000                    0 #> TSC2                0.0000000             0.000000                    0 #>          X70_Y-84..Fibroblast X54_Y-67..Fibroblast X49_Y-67..Fibroblast #> PDK4                 0.000000            1.0191191            0.2942464 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  2.682937            0.0000000            1.1852386 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.6810631            0.0000000 #>          X48_Y-67..Fibroblast X49_Y-68..Fibroblast X52_Y-68..Fibroblast #> PDK4                0.2953210            0.0000000            0.9544500 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.7266446            2.0587828            0.7822726 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.7324082            0.0000000 #>          X50_Y-68..Fibroblast X48_Y-68..Fibroblast X49_Y-69..Fibroblast #> PDK4                0.6520692             0.000000            0.5483535 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.0000000             1.078271            0.0000000 #> GZMB                0.6520692             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.6277785 #>          X50_Y-69..Fibroblast X51_Y-69..Fibroblast X49_Y-70..Fibroblast #> PDK4                0.3009550             0.000000            0.6397457 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.3075199             1.246015            0.5700893 #> GZMB                0.3009550             0.000000            0.7114356 #> TSC2                0.3380346             0.000000            0.0000000 #>          X52_Y-70..Fibroblast X50_Y-70..Fibroblast X51_Y-70..Fibroblast #> PDK4                0.5700893            0.0000000             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 1.2650347            1.2363825             2.024152 #> GZMB                0.0000000            0.7114356             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X53_Y-70..Fibroblast X52_Y-71..Fibroblast X53_Y-71..Fibroblast #> PDK4                 1.056547            0.3871826             1.056547 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  1.167073            0.9297641             1.167073 #> GZMB                 0.000000            0.0000000             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X48_Y-71..Fibroblast X48_Y-72..Fibroblast X53_Y-72..Fibroblast #> PDK4                0.3249031            1.9809592                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.3499046            0.9603879                    0 #> GZMB                0.0000000            1.1145511                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X54_Y-72..Fibroblast X51_Y-68..Fibroblast X52_Y-69..Fibroblast #> PDK4                 0.000000            0.6926802             1.140179 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  1.908245            0.4735860             2.323229 #> GZMB                 0.000000            0.0000000             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X65_Y-64..Fibroblast X63_Y-64..Fibroblast X66_Y-64..Fibroblast #> PDK4                0.0000000            0.6011077            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.5416504            0.7143549            1.0861320 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.4803665 #>          X64_Y-64..Fibroblast X66_Y-65..Fibroblast X65_Y-65..Fibroblast #> PDK4                0.4007385            0.0000000            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.4762366            0.8689056            0.8437246 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.3842932            0.3493575 #>          X64_Y-65..Fibroblast X64_Y-66..Fibroblast X63_Y-65..Fibroblast #> PDK4                0.3278770            0.0000000            0.9016616 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.3896481            1.6681661            1.0715323 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.2804934            0.6170856            0.0000000 #>          X59_Y-79..Fibroblast X58_Y-79..Fibroblast X55_Y-80..Fibroblast #> PDK4                  0.00000            0.4087870            0.0000000 #> TNFRSF17              0.00000            0.0000000            0.0000000 #> ICAM3                 0.00000            0.0000000            0.0000000 #> FAP                   1.01327            0.7880987            0.5555282 #> GZMB                  0.00000            0.0000000            0.6716302 #> TSC2                  0.00000            0.0000000            0.0000000 #>          X59_Y-80..Fibroblast X56_Y-80..Fibroblast X57_Y-80..Fibroblast #> PDK4                0.2830064            0.5734643            0.6881572 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.9725001            0.7068714            1.6760085 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X54_Y-80..Fibroblast X58_Y-80..Fibroblast X60_Y-80..Fibroblast #> PDK4                 1.588185            0.3344621             0.000000 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  0.000000            0.2823246             1.377386 #> GZMB                 1.481016            0.0000000             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X58_Y-81..Fibroblast X59_Y-81..Fibroblast X60_Y-81..Fibroblast #> PDK4                0.4471008            0.2649770            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.1491867            0.5745604            1.1269521 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.3719454 #>          X55_Y-81..Fibroblast X56_Y-81..Fibroblast X57_Y-81..Fibroblast #> PDK4                0.3030154            0.3030154             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 1.6433451            1.0848382             1.874266 #> GZMB                0.3663438            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X58_Y-82..Fibroblast X57_Y-82..Fibroblast X55_Y-82..Fibroblast #> PDK4                0.5102614              0.00000            0.4264987 #> TNFRSF17            0.0000000              0.00000            0.0000000 #> ICAM3               0.0000000              0.00000            0.0000000 #> FAP                 0.9445865              1.18032            1.7989371 #> GZMB                0.0000000              0.00000            0.0000000 #> TSC2                0.0000000              0.00000            0.4016894 #>          X59_Y-82..Fibroblast X56_Y-82..Fibroblast X60_Y-82..Fibroblast #> PDK4                0.4622698             0.000000            0.3992713 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.7030034             1.732932            0.5427514 #> GZMB                0.0000000             0.000000            0.7670026 #> TSC2                0.0000000             0.000000            0.3250838 #>          X56_Y-83..Fibroblast X54_Y-83..Fibroblast X57_Y-83..Fibroblast #> PDK4                 0.369487             0.000000            0.3513646 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  0.000000             1.625002            0.9301167 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X55_Y-83..Fibroblast X58_Y-84..Fibroblast X59_Y-84..Fibroblast #> PDK4                        0            0.7531407                    0 #> TNFRSF17                    0            0.0000000                    0 #> ICAM3                       0            0.0000000                    0 #> FAP                         0            0.5342627                    0 #> GZMB                        0            0.0000000                    0 #> TSC2                        0            0.0000000                    0 #>          X56_Y-84..Fibroblast X57_Y-84..Fibroblast X60_Y-84..Fibroblast #> PDK4                0.7971641                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 0.0000000                    0                    0 #> GZMB                0.0000000                    0                    0 #> TSC2                0.0000000                    0                    0 #>          X54_Y-85..Fibroblast X54_Y-79..Fibroblast X58_Y-83..Fibroblast #> PDK4                  0.94769                    0            0.7697761 #> TNFRSF17              0.00000                    0            0.0000000 #> ICAM3                 0.00000                    0            0.0000000 #> FAP                   0.00000                    0            0.7608086 #> GZMB                  0.00000                    0            0.0000000 #> TSC2                  0.00000                    0            0.0000000 #>          X54_Y-84..Fibroblast X56_Y-85..Fibroblast X65_Y-82..Fibroblast #> PDK4                        0                    0             3.749358 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X62_Y-83..Fibroblast X61_Y-83..Fibroblast X64_Y-83..Fibroblast #> PDK4                        0                    0            0.0000000 #> TNFRSF17                    0                    0            0.0000000 #> ICAM3                       0                    0            0.0000000 #> FAP                         0                    0            0.7033122 #> GZMB                        0                    0            0.3415058 #> TSC2                        0                    0            0.0000000 #>          X63_Y-83..Fibroblast X64_Y-84..Fibroblast X62_Y-84..Fibroblast #> PDK4                0.0000000            0.0000000            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            0.9042585            0.7667927 #> GZMB                0.5122587            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X63_Y-84..Fibroblast X66_Y-84..Fibroblast X65_Y-84..Fibroblast #> PDK4                        0             0.000000            0.6036479 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             1.313656            2.0708715 #> GZMB                        0             0.000000            0.0000000 #> TSC2                        0             0.000000            0.0000000 #>          X62_Y-85..Fibroblast X61_Y-85..Fibroblast X60_Y-83..Fibroblast #> PDK4                0.6060952            0.3527584            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            1.5277791            0.0000000 #> GZMB                0.0000000            0.0000000            1.7896728 #> TSC2                0.0000000            0.0000000            0.7585288 #>          X61_Y-84..Fibroblast X32_Y-91..Fibroblast X34_Y-91..Fibroblast #> PDK4                        0            0.4913859            0.0000000 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.5975760            0.7136374 #> GZMB                        0            0.0000000            0.7136374 #> TSC2                        0            0.0000000            0.0000000 #>          X31_Y-91..Fibroblast X33_Y-91..Fibroblast X36_Y-91..Fibroblast #> PDK4                0.0000000                    0            0.4007385 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.5121273                    0            1.1374998 #> GZMB                0.0000000                    0            0.0000000 #> TSC2                0.0000000                    0            0.0000000 #>          X32_Y-92..Fibroblast X31_Y-92..Fibroblast X33_Y-92..Fibroblast #> PDK4                0.2330316            0.8620521             1.031685 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 1.1063139            0.2295977             1.202947 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.2686050            0.1939925             0.000000 #>          X34_Y-92..Fibroblast X30_Y-92..Fibroblast X32_Y-93..Fibroblast #> PDK4                 1.492061             1.403311            0.0000000 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  0.000000             0.000000            1.4181108 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.4364831 #>          X31_Y-93..Fibroblast X34_Y-93..Fibroblast X35_Y-93..Fibroblast #> PDK4                0.6927086            0.4607720            0.6748139 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.3530923            0.4895181            0.2771153 #> GZMB                0.0000000            0.0000000            0.2771153 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X33_Y-93..Fibroblast X36_Y-93..Fibroblast X31_Y-94..Fibroblast #> PDK4                0.4331234            0.4589481            0.4468283 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 2.0740310            0.8601333            0.7735926 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X34_Y-94..Fibroblast X35_Y-94..Fibroblast X33_Y-94..Fibroblast #> PDK4                0.7679533            1.0085632             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.4264971            0.3824862             2.252535 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X36_Y-94..Fibroblast X32_Y-95..Fibroblast X36_Y-95..Fibroblast #> PDK4                 1.141536            0.6559976            0.4034861 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.022994            0.7908283            0.8408755 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X33_Y-95..Fibroblast X31_Y-95..Fibroblast X35_Y-95..Fibroblast #> PDK4                        0             0.000000             0.000000 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             0.577829             1.415694 #> GZMB                        0             0.000000             0.000000 #> TSC2                        0             0.000000             0.000000 #>          X34_Y-95..Fibroblast X29_Y-95..Fibroblast X33_Y-96..Fibroblast #> PDK4                        0                    0             0.724693 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X31_Y-96..Fibroblast X35_Y-96..Fibroblast X32_Y-96..Fibroblast #> PDK4                 1.049159                    0             0.000000 #> TNFRSF17             0.000000                    0             0.000000 #> ICAM3                0.000000                    0             0.000000 #> FAP                  2.050605                    0             2.003961 #> GZMB                 0.000000                    0             0.000000 #> TSC2                 0.000000                    0             0.000000 #>          X30_Y-96..Fibroblast X34_Y-96..Fibroblast X30_Y-97..Fibroblast #> PDK4                0.9860738                    0             1.362828 #> TNFRSF17            0.0000000                    0             0.000000 #> ICAM3               0.0000000                    0             0.000000 #> FAP                 2.1868740                    0             2.651363 #> GZMB                0.0000000                    0             0.000000 #> TSC2                0.0000000                    0             0.000000 #>          X31_Y-97..Fibroblast X33_Y-97..Fibroblast X35_Y-97..Fibroblast #> PDK4                0.9860738            1.2081524             1.012045 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 1.5122415            0.6371141             1.949802 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X34_Y-97..Fibroblast X36_Y-97..Fibroblast X30_Y-98..Fibroblast #> PDK4                0.7246930             0.650885            0.0000000 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.7432998             1.519027            0.7938623 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.0000000 #>          X35_Y-98..Fibroblast X35_Y-91..Fibroblast X35_Y-92..Fibroblast #> PDK4                0.7109386            0.5292989            0.3803539 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.3185725            0.8006961            0.8513111 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X36_Y-92..Fibroblast X32_Y-97..Fibroblast X48_Y-85..Fibroblast #> PDK4                 1.612226              0.00000             3.091379 #> TNFRSF17             0.000000              0.00000             0.000000 #> ICAM3                0.000000              0.00000             0.000000 #> FAP                  1.067072              1.29937             0.000000 #> GZMB                 0.000000              0.00000             0.000000 #> TSC2                 0.000000              0.00000             0.000000 #>          X42_Y-86..Fibroblast X45_Y-86..Fibroblast X44_Y-86..Fibroblast #> PDK4                        0            0.0000000            0.0000000 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.2779782            1.1642710 #> GZMB                        0            0.0000000            0.3481473 #> TSC2                        0            0.0000000            0.0000000 #>          X47_Y-86..Fibroblast X43_Y-86..Fibroblast X44_Y-87..Fibroblast #> PDK4                0.9530384                    0            0.8519318 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.7810218                    0            0.3965608 #> GZMB                0.0000000                    0            0.3973081 #> TSC2                0.0000000                    0            0.0000000 #>          X45_Y-87..Fibroblast X47_Y-87..Fibroblast X46_Y-88..Fibroblast #> PDK4                0.8218521            0.6404887             3.131032 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.5305546            1.9234846             0.000000 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X47_Y-88..Fibroblast X44_Y-88..Fibroblast X45_Y-88..Fibroblast #> PDK4                0.9316851            0.4898801            1.1422085 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.6195601            0.9571056            0.2767914 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.3826947            0.0000000            0.0000000 #>          X48_Y-88..Fibroblast X47_Y-89..Fibroblast X44_Y-89..Fibroblast #> PDK4                0.1799321            0.5327118            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.5533490            1.6696563            0.9829564 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X48_Y-89..Fibroblast X45_Y-89..Fibroblast X46_Y-89..Fibroblast #> PDK4                 0.000000             0.348282             0.000000 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  2.436306             1.559988             1.502301 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             0.000000 #>          X42_Y-89..Fibroblast X45_Y-90..Fibroblast X46_Y-90..Fibroblast #> PDK4                  0.00000             0.000000            0.5921766 #> TNFRSF17              0.00000             0.000000            0.0000000 #> ICAM3                 0.00000             0.000000            0.0000000 #> FAP                   1.84332             2.436767            2.2945924 #> GZMB                  0.00000             0.000000            0.0000000 #> TSC2                  0.00000             0.000000            0.0000000 #>          X44_Y-90..Fibroblast X48_Y-90..Fibroblast X47_Y-90..Fibroblast #> PDK4                0.0000000            0.0000000            0.3874268 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.5739525            0.5654759            0.7967354 #> GZMB                0.6082402            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X43_Y-90..Fibroblast X42_Y-90..Fibroblast X47_Y-91..Fibroblast #> PDK4                0.4810974            0.0000000             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 1.1636225            0.7624308             1.580059 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X45_Y-91..Fibroblast X48_Y-91..Fibroblast X50_Y-80..Fibroblast #> PDK4                        0                    0            0.8307005 #> TNFRSF17                    0                    0            0.0000000 #> ICAM3                       0                    0            0.0000000 #> FAP                         0                    0            0.0000000 #> GZMB                        0                    0            0.8537074 #> TSC2                        0                    0            0.0000000 #>          X51_Y-80..Fibroblast X52_Y-80..Fibroblast X52_Y-81..Fibroblast #> PDK4                 0.000000             0.000000            0.0000000 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  1.919656             1.578154            0.8006046 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X49_Y-80..Fibroblast X50_Y-81..Fibroblast X53_Y-81..Fibroblast #> PDK4                 0.000000            0.4746860            0.9494038 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.000000            0.0000000            0.9775673 #> GZMB                 0.000000            0.4878328            0.0000000 #> TSC2                 1.531839            0.0000000            0.0000000 #>          X49_Y-81..Fibroblast X51_Y-81..Fibroblast X54_Y-81..Fibroblast #> PDK4                0.9864785            0.0000000             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.0000000            1.1344363             2.375059 #> GZMB                0.0000000            0.5691383             0.000000 #> TSC2                0.6565023            0.0000000             0.000000 #>          X53_Y-82..Fibroblast X51_Y-82..Fibroblast X50_Y-82..Fibroblast #> PDK4                0.6645827                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 1.0051916                    0                    0 #> GZMB                0.0000000                    0                    0 #> TSC2                0.0000000                    0                    0 #>          X54_Y-82..Fibroblast X53_Y-83..Fibroblast X50_Y-83..Fibroblast #> PDK4                 0.781542             1.268855            0.5470754 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  1.457345             1.267023            1.0396900 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X51_Y-83..Fibroblast X52_Y-83..Fibroblast X51_Y-84..Fibroblast #> PDK4                 1.032663            0.0000000            1.0849612 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.636216            0.0000000            0.5965257 #> GZMB                 0.000000            0.7291601            0.0000000 #> TSC2                 0.000000            0.0000000            0.5794252 #>          X52_Y-84..Fibroblast X53_Y-84..Fibroblast X52_Y-85..Fibroblast #> PDK4                0.0000000            0.0000000            0.8899950 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.7989342            0.8745151            0.8808254 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X53_Y-85..Fibroblast X53_Y-80..Fibroblast X71_Y-91..Fibroblast #> PDK4                0.8385641            0.0000000            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.8385641            0.8523389            0.6993181 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X70_Y-91..Fibroblast X69_Y-91..Fibroblast X71_Y-92..Fibroblast #> PDK4                 0.000000            0.0000000            0.3846092 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.495581            0.4769423            0.3446119 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X70_Y-92..Fibroblast X69_Y-92..Fibroblast X73_Y-92..Fibroblast #> PDK4                0.6686247            0.0000000                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.0000000            0.5909636                    0 #> GZMB                0.0000000            0.0000000                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X72_Y-92..Fibroblast X69_Y-93..Fibroblast X67_Y-93..Fibroblast #> PDK4                0.0000000            0.0000000            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.4756353            0.4686697            0.0000000 #> GZMB                0.0000000            0.4990655            0.6797361 #> TSC2                0.2298649            0.0000000            0.0000000 #>          X71_Y-93..Fibroblast X72_Y-93..Fibroblast X68_Y-93..Fibroblast #> PDK4                        0            0.3484487            0.0000000 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.5122226            0.5263264 #> GZMB                        0            0.0000000            0.6654206 #> TSC2                        0            0.2475468            0.0000000 #>          X70_Y-93..Fibroblast X72_Y-94..Fibroblast X69_Y-94..Fibroblast #> PDK4                        0            0.5662292            0.0000000 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.3892193            0.5311957 #> GZMB                        0            0.0000000            0.0000000 #> TSC2                        0            0.0000000            0.0000000 #>          X68_Y-94..Fibroblast X70_Y-94..Fibroblast X73_Y-94..Fibroblast #> PDK4                0.0000000                    0            0.4682882 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.6108193                    0            0.0000000 #> GZMB                0.0000000                    0            0.4682882 #> TSC2                0.0000000                    0            0.0000000 #>          X67_Y-94..Fibroblast X69_Y-95..Fibroblast X72_Y-95..Fibroblast #> PDK4                0.0000000            0.0000000                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.6828667            0.5843153                    0 #> GZMB                0.4531574            0.0000000                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X71_Y-95..Fibroblast X68_Y-95..Fibroblast X70_Y-95..Fibroblast #> PDK4                0.3246152            0.2694161                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.0000000            0.5854707                    0 #> GZMB                0.0000000            0.0000000                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X71_Y-96..Fibroblast X72_Y-96..Fibroblast X69_Y-96..Fibroblast #> PDK4                0.3318059            0.0000000             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.2470356            0.8997735             1.425194 #> GZMB                0.0000000            1.2226195             0.000000 #> TSC2                0.0000000            0.9198535             0.000000 #>          X70_Y-96..Fibroblast X71_Y-97..Fibroblast X72_Y-97..Fibroblast #> PDK4                        0            0.5024364            0.0000000 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.0000000            0.3375975 #> GZMB                        0            0.0000000            0.0000000 #> TSC2                        0            0.0000000            0.0000000 #>          X70_Y-97..Fibroblast X68_Y-97..Fibroblast X66_Y-92..Fibroblast #> PDK4                  1.14396             0.000000                    0 #> TNFRSF17              0.00000             0.000000                    0 #> ICAM3                 0.00000             0.000000                    0 #> FAP                   0.00000             2.503386                    0 #> GZMB                  0.00000             0.000000                    0 #> TSC2                  0.00000             0.000000                    0 #>          X68_Y-92..Fibroblast X73_Y-93..Fibroblast X71_Y-94..Fibroblast #> PDK4                        0            0.3010424                    0 #> TNFRSF17                    0            0.0000000                    0 #> ICAM3                       0            0.0000000                    0 #> FAP                         0            0.2848084                    0 #> GZMB                        0            0.3010424                    0 #> TSC2                        0            0.0000000                    0 #>          X69_Y-97..Fibroblast X69_Y-98..Fibroblast X25_Y-64..Fibroblast #> PDK4                 0.000000            0.0000000             1.205574 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  2.232814            0.6528176             0.000000 #> GZMB                 0.000000            0.0000000             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X27_Y-64..Fibroblast X27_Y-65..Fibroblast X26_Y-65..Fibroblast #> PDK4                1.9412647            0.7335717            0.5956675 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.8300571            1.4213533            0.0000000 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X25_Y-65..Fibroblast X28_Y-65..Fibroblast X24_Y-65..Fibroblast #> PDK4                0.5956675                    0            0.7052915 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.0000000                    0            0.0000000 #> GZMB                0.0000000                    0            0.0000000 #> TSC2                0.0000000                    0            0.0000000 #>          X26_Y-66..Fibroblast X28_Y-66..Fibroblast X27_Y-66..Fibroblast #> PDK4                        0            0.6036479                    0 #> TNFRSF17                    0            0.0000000                    0 #> ICAM3                       0            0.0000000                    0 #> FAP                         0            0.0000000                    0 #> GZMB                        0            0.6445448                    0 #> TSC2                        0            0.0000000                    0 #>          X26_Y-64..Fibroblast X29_Y-65..Fibroblast X77_Y-92..Fibroblast #> PDK4                0.8339345             3.988079            0.5890774 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.0000000             0.000000            1.5538205 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.0000000 #>          X76_Y-92..Fibroblast X75_Y-92..Fibroblast X78_Y-92..Fibroblast #> PDK4                        0             0.000000            0.0000000 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             1.335811            0.0000000 #> GZMB                        0             0.000000            0.9230241 #> TSC2                        0             0.000000            0.0000000 #>          X74_Y-92..Fibroblast X75_Y-93..Fibroblast X76_Y-93..Fibroblast #> PDK4                        0            0.0000000            0.0000000 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.3583345            0.2815486 #> GZMB                        0            0.0000000            0.0000000 #> TSC2                        0            0.0000000            0.0000000 #>          X78_Y-93..Fibroblast X74_Y-93..Fibroblast X77_Y-93..Fibroblast #> PDK4                0.0000000            0.0000000                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.8379783            0.2646145                    0 #> GZMB                0.4364831            0.0000000                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X75_Y-94..Fibroblast X78_Y-94..Fibroblast X74_Y-94..Fibroblast #> PDK4                0.0000000            0.0000000            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.9957762            0.9450024            0.9809143 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X77_Y-94..Fibroblast X76_Y-95..Fibroblast X78_Y-95..Fibroblast #> PDK4                 1.027964             0.000000                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  0.000000             2.666444                    0 #> GZMB                 0.000000             0.000000                    0 #> TSC2                 0.000000             0.000000                    0 #>          X75_Y-95..Fibroblast X75_Y-96..Fibroblast X78_Y-96..Fibroblast #> PDK4                 0.000000            0.0000000                    0 #> TNFRSF17             0.000000            0.0000000                    0 #> ICAM3                0.000000            0.0000000                    0 #> FAP                  1.517629            0.9177349                    0 #> GZMB                 0.000000            0.5921297                    0 #> TSC2                 0.000000            0.0000000                    0 #>          X76_Y-96..Fibroblast X79_Y-96..Fibroblast X74_Y-96..Fibroblast #> PDK4                 0.000000                    0                    0 #> TNFRSF17             0.000000                    0                    0 #> ICAM3                0.000000                    0                    0 #> FAP                  1.241289                    0                    0 #> GZMB                 0.000000                    0                    0 #> TSC2                 0.000000                    0                    0 #>          X78_Y-97..Fibroblast X76_Y-94..Fibroblast X79_Y-94..Fibroblast #> PDK4                        0             1.202215             0.000000 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             0.000000             1.181253 #> GZMB                        0             0.000000             0.000000 #> TSC2                        0             0.000000             0.000000 #>          X73_Y-95..Fibroblast X74_Y-95..Fibroblast X77_Y-95..Fibroblast #> PDK4                 0.000000            0.0000000             0.000000 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  0.000000            0.6484216             1.341457 #> GZMB                 1.944345            0.6665598             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X77_Y-96..Fibroblast X77_Y-97..Fibroblast X43_Y-67..Fibroblast #> PDK4                 0.000000            0.0000000             1.200953 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  1.341457            0.5101034             1.019397 #> GZMB                 0.000000            0.0000000             0.000000 #> TSC2                 1.016752            0.0000000             0.000000 #>          X45_Y-67..Fibroblast X45_Y-68..Fibroblast X47_Y-68..Fibroblast #> PDK4                0.9955428            0.6958559            1.2983444 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 2.0349010            1.4200076            0.8721409 #> GZMB                0.2337544            0.2337544            0.0000000 #> TSC2                0.3682038            0.3682038            0.0000000 #>          X43_Y-68..Fibroblast X46_Y-68..Fibroblast X44_Y-68..Fibroblast #> PDK4                0.8252197            0.0000000             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 1.0036491            0.5984861             1.497411 #> GZMB                0.0000000            0.3605435             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X43_Y-69..Fibroblast X44_Y-69..Fibroblast X46_Y-69..Fibroblast #> PDK4                 0.000000            0.3987317            0.3417245 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.608985            0.7592822            0.7538191 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.3351594            0.0000000 #>          X48_Y-69..Fibroblast X47_Y-69..Fibroblast X45_Y-69..Fibroblast #> PDK4                0.0000000            0.5606847            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.3397727            0.0000000            0.6255697 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X47_Y-70..Fibroblast X46_Y-70..Fibroblast X45_Y-70..Fibroblast #> PDK4                0.9018725             0.000000            0.0000000 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 1.1547720             1.839533            0.7093350 #> GZMB                0.0000000             0.000000            0.3769273 #> TSC2                0.0000000             0.000000            0.0000000 #>          X44_Y-70..Fibroblast X43_Y-70..Fibroblast X43_Y-71..Fibroblast #> PDK4                0.0000000            1.1786316            0.7539529 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.7644185            0.6717718            1.4266404 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.2745421            0.2745421 #>          X44_Y-71..Fibroblast X45_Y-71..Fibroblast X46_Y-71..Fibroblast #> PDK4                 1.321588                    0              0.00000 #> TNFRSF17             0.000000                    0              0.00000 #> ICAM3                0.000000                    0              0.00000 #> FAP                  1.474175                    0              1.26365 #> GZMB                 0.000000                    0              0.00000 #> TSC2                 0.000000                    0              0.00000 #>          X47_Y-71..Fibroblast X46_Y-72..Fibroblast X42_Y-72..Fibroblast #> PDK4                        0              0.00000            0.5585990 #> TNFRSF17                    0              0.00000            0.0000000 #> ICAM3                       0              0.00000            0.0000000 #> FAP                         0              1.16572            0.6368079 #> GZMB                        0              0.00000            0.0000000 #> TSC2                        0              0.00000            0.0000000 #>          X48_Y-70..Fibroblast X74_Y-64..Fibroblast X73_Y-65..Fibroblast #> PDK4                   1.8975            0.7065772            0.8832215 #> TNFRSF17               0.0000            0.0000000            0.0000000 #> ICAM3                  0.0000            0.0000000            0.0000000 #> FAP                    0.0000            0.0000000            0.0000000 #> GZMB                   0.0000            0.7085223            0.0000000 #> TSC2                   0.0000            0.0000000            0.0000000 #>          X78_Y-65..Fibroblast X74_Y-65..Fibroblast X77_Y-66..Fibroblast #> PDK4                 0.000000            0.3532886                    0 #> TNFRSF17             0.000000            0.0000000                    0 #> ICAM3                0.000000            0.0000000                    0 #> FAP                  0.606633            0.3847411                    0 #> GZMB                 0.000000            0.3542611                    0 #> TSC2                 0.000000            0.0000000                    0 #>          X22_Y-91..Fibroblast X22_Y-92..Fibroblast X22_Y-93..Fibroblast #> PDK4                 0.000000                    0            1.2601084 #> TNFRSF17             0.000000                    0            0.0000000 #> ICAM3                0.000000                    0            0.0000000 #> FAP                  4.660719                    0            0.6550156 #> GZMB                 0.000000                    0            0.0000000 #> TSC2                 0.000000                    0            0.0000000 #>          X22_Y-94..Fibroblast X23_Y-94..Fibroblast X22_Y-95..Fibroblast #> PDK4                0.5491457            0.8237186            0.4706963 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.2471737            1.8707605            1.1141331 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X23_Y-95..Fibroblast X23_Y-96..Fibroblast X22_Y-96..Fibroblast #> PDK4                 0.000000            0.9275778            0.0000000 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.765924            0.4743751            0.4319404 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X22_Y-97..Fibroblast X23_Y-86..Fibroblast X25_Y-86..Fibroblast #> PDK4                0.3846092            0.9220365             1.176555 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.3839470            0.0000000             0.000000 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X24_Y-86..Fibroblast X23_Y-87..Fibroblast X24_Y-87..Fibroblast #> PDK4                0.8537227             1.202215            0.4742904 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.0000000             0.000000            0.4390707 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.0000000 #>          X26_Y-87..Fibroblast X25_Y-87..Fibroblast X28_Y-88..Fibroblast #> PDK4                0.2396778            0.3557178            1.8343112 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.6164890            0.3293030            0.2924386 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X27_Y-88..Fibroblast X25_Y-88..Fibroblast X26_Y-88..Fibroblast #> PDK4                 2.190897            0.5643814            0.6529418 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.000000            0.6240395            0.9710765 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.3662041            0.0000000 #>          X27_Y-89..Fibroblast X28_Y-89..Fibroblast X26_Y-89..Fibroblast #> PDK4                0.0000000            0.4909384            1.4927736 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.6404887            0.4578623            0.9351866 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X24_Y-89..Fibroblast X27_Y-90..Fibroblast X28_Y-90..Fibroblast #> PDK4                0.6100748                    0            0.7013413 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 2.7904740                    0            0.0000000 #> GZMB                0.0000000                    0            0.0000000 #> TSC2                0.0000000                    0            0.0000000 #>          X24_Y-90..Fibroblast X23_Y-91..Fibroblast X29_Y-91..Fibroblast #> PDK4                0.4580956             1.060771            0.0000000 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 1.7025178             1.319003            0.6402472 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.0000000 #>          X24_Y-88..Fibroblast X29_Y-88..Fibroblast X25_Y-89..Fibroblast #> PDK4                  0.00000            0.7721949            0.0000000 #> TNFRSF17              0.00000            0.0000000            0.0000000 #> ICAM3                 0.00000            0.0000000            0.0000000 #> FAP                   1.84522            0.8773159            0.6169894 #> GZMB                  0.00000            0.0000000            0.0000000 #> TSC2                  0.00000            0.0000000            0.0000000 #>          X23_Y-89..Fibroblast X25_Y-90..Fibroblast X33_Y-85..Fibroblast #> PDK4                 1.502472             0.000000            0.2527525 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  2.311363             1.388847            0.0000000 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X34_Y-85..Fibroblast X36_Y-85..Fibroblast X35_Y-86..Fibroblast #> PDK4                0.5594877            0.4031616            0.2908975 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.2210073            0.0000000            0.9772639 #> GZMB                0.0000000            0.4177742            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X34_Y-86..Fibroblast X36_Y-86..Fibroblast X33_Y-86..Fibroblast #> PDK4                0.8195374            0.0000000            0.9540838 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.1274096            0.7239327            0.0000000 #> GZMB                0.4639960            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X33_Y-87..Fibroblast X34_Y-87..Fibroblast X35_Y-87..Fibroblast #> PDK4                 1.064954                    0                    0 #> TNFRSF17             0.000000                    0                    0 #> ICAM3                0.000000                    0                    0 #> FAP                  0.000000                    0                    0 #> GZMB                 0.000000                    0                    0 #> TSC2                 0.000000                    0                    0 #>          X36_Y-88..Fibroblast X33_Y-88..Fibroblast X34_Y-88..Fibroblast #> PDK4                0.0000000            0.5835165            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.8442717            0.5460596            0.5939217 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.2893768            0.0000000 #>          X35_Y-88..Fibroblast X33_Y-89..Fibroblast X34_Y-89..Fibroblast #> PDK4                        0            0.3361899            0.9353221 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.0000000            0.4882721 #> GZMB                        0            0.0000000            0.0000000 #> TSC2                        0            0.3946047            0.0000000 #>          X35_Y-89..Fibroblast X33_Y-90..Fibroblast X34_Y-90..Fibroblast #> PDK4                 0.773358             1.121304            1.0503018 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  2.216575             0.000000            0.7324082 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X36_Y-90..Fibroblast X35_Y-90..Fibroblast X32_Y-87..Fibroblast #> PDK4                0.6131804             0.000000             1.138487 #> TNFRSF17            0.0000000             0.000000             0.000000 #> ICAM3               0.0000000             0.000000             0.000000 #> FAP                 1.3586549             1.069596             0.000000 #> GZMB                0.0000000             0.000000             0.000000 #> TSC2                0.0000000             0.000000             0.000000 #>          X32_Y-88..Fibroblast X36_Y-89..Fibroblast X32_Y-90..Fibroblast #> PDK4                 0.000000            0.3733287             1.070299 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  1.170128            0.4062903             0.000000 #> GZMB                 0.000000            0.0000000             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X40_Y-85..Fibroblast X39_Y-85..Fibroblast X41_Y-86..Fibroblast #> PDK4                 1.461681            0.0000000            0.7983858 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.354968            0.8609287            0.0000000 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.4234501 #>          X37_Y-86..Fibroblast X40_Y-86..Fibroblast X40_Y-87..Fibroblast #> PDK4                 0.000000             0.000000             0.000000 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  1.739261             3.551787             2.009987 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             0.000000 #>          X41_Y-87..Fibroblast X36_Y-87..Fibroblast X39_Y-88..Fibroblast #> PDK4                  0.00000             0.000000             0.000000 #> TNFRSF17              0.00000             0.000000             0.000000 #> ICAM3                 0.00000             0.000000             0.000000 #> FAP                   1.01568             1.688543             1.745743 #> GZMB                  0.00000             0.000000             0.000000 #> TSC2                  0.00000             0.000000             0.000000 #>          X40_Y-88..Fibroblast X38_Y-88..Fibroblast X41_Y-88..Fibroblast #> PDK4                0.3514126            0.9087402            0.9722598 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 2.3713854            0.7495276            2.1163279 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.3906175            0.0000000            0.0000000 #>          X39_Y-89..Fibroblast X38_Y-89..Fibroblast X37_Y-89..Fibroblast #> PDK4                  0.00000            1.4628087            0.7254463 #> TNFRSF17              0.00000            0.0000000            0.0000000 #> ICAM3                 0.00000            0.0000000            0.0000000 #> FAP                   1.44639            0.0000000            0.4514337 #> GZMB                  0.00000            0.0000000            0.0000000 #> TSC2                  0.00000            0.8565202            0.0000000 #>          X41_Y-89..Fibroblast X40_Y-89..Fibroblast X39_Y-90..Fibroblast #> PDK4                0.7608781             0.000000            0.4439977 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.3430469             1.951116            0.7020623 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.4774214             0.000000            0.0000000 #>          X41_Y-90..Fibroblast X40_Y-90..Fibroblast X37_Y-90..Fibroblast #> PDK4                0.8002945            0.0000000            0.8512150 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.9082579            0.6962301            0.5128796 #> GZMB                0.2630610            0.0000000            0.4257918 #> TSC2                0.2581176            0.0000000            0.0000000 #>          X38_Y-90..Fibroblast X39_Y-91..Fibroblast X40_Y-91..Fibroblast #> PDK4                0.0000000            0.3898331            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.8206074            0.3679269            0.9841066 #> GZMB                0.0000000            0.1670511            0.3301969 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X38_Y-91..Fibroblast X41_Y-91..Fibroblast X34_Y-98..Fibroblast #> PDK4                0.3291544            0.2258529            0.4436138 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.3730033            0.9088774            0.9396309 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.2258529            0.0000000 #>          X29_Y-98..Fibroblast X33_Y-98..Fibroblast X32_Y-98..Fibroblast #> PDK4                 0.000000            0.0000000            0.8359921 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.984656            0.7531407            1.2612984 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X31_Y-98..Fibroblast X31_Y-99..Fibroblast X35_Y-99..Fibroblast #> PDK4                0.8339345                    0             0.000000 #> TNFRSF17            0.0000000                    0             0.000000 #> ICAM3               0.0000000                    0             0.000000 #> FAP                 0.6390740                    0             1.587004 #> GZMB                0.0000000                    0             0.000000 #> TSC2                0.0000000                    0             0.000000 #>          X32_Y-99..Fibroblast X33_Y-99..Fibroblast X34_Y-99..Fibroblast #> PDK4                0.7346836            0.6565023            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.9068471            0.9601688            0.6609866 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.2618093            0.4862172            0.0000000 #>          X30_Y-99..Fibroblast X32_Y-100..Fibroblast X33_Y-100..Fibroblast #> PDK4                 1.714302             0.7023254             0.4595516 #> TNFRSF17             0.000000             0.0000000             0.0000000 #> ICAM3                0.000000             0.0000000             0.0000000 #> FAP                  1.278012             1.2066830             0.7876074 #> GZMB                 0.000000             0.0000000             0.0000000 #> TSC2                 0.000000             0.0000000             0.3403520 #>          X35_Y-100..Fibroblast X31_Y-100..Fibroblast X29_Y-100..Fibroblast #> PDK4                 0.4124863             0.8356205              0.000000 #> TNFRSF17             0.0000000             0.0000000              0.000000 #> ICAM3                0.0000000             0.0000000              0.000000 #> FAP                  1.4176363             0.0000000              1.232696 #> GZMB                 0.0000000             0.0000000              0.000000 #> TSC2                 0.0000000             0.0000000              0.000000 #>          X36_Y-100..Fibroblast X34_Y-100..Fibroblast X32_Y-101..Fibroblast #> PDK4                  1.250693              0.000000              1.067077 #> TNFRSF17              0.000000              0.000000              0.000000 #> ICAM3                 0.000000              0.000000              0.000000 #> FAP                   1.788182              0.527648              1.142526 #> GZMB                  0.000000              0.000000              0.000000 #> TSC2                  0.000000              0.000000              0.000000 #>          X31_Y-101..Fibroblast X34_Y-101..Fibroblast X35_Y-101..Fibroblast #> PDK4                 1.3732896             0.3518295                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.7137668             0.3569942                     0 #> GZMB                 0.0000000             0.0000000                     0 #> TSC2                 0.6473359             0.0000000                     0 #>          X36_Y-102..Fibroblast X34_Y-102..Fibroblast X30_Y-102..Fibroblast #> PDK4                  1.652467             0.4837656                     0 #> TNFRSF17              0.000000             0.0000000                     0 #> ICAM3                 0.000000             0.0000000                     0 #> FAP                   2.559910             0.5092751                     0 #> GZMB                  0.000000             0.0000000                     0 #> TSC2                  0.000000             0.0000000                     0 #>          X33_Y-102..Fibroblast X31_Y-102..Fibroblast X33_Y-103..Fibroblast #> PDK4                  0.000000              1.414747             0.7705019 #> TNFRSF17              0.000000              0.000000             0.0000000 #> ICAM3                 0.000000              0.000000             0.0000000 #> FAP                   1.153877              0.000000             0.9705374 #> GZMB                  0.000000              0.000000             0.0000000 #> TSC2                  0.000000              0.000000             0.0000000 #>          X30_Y-103..Fibroblast X31_Y-103..Fibroblast X34_Y-103..Fibroblast #> PDK4                 0.0000000             0.6887931             0.5650348 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.0000000             0.4962571 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.6540389             0.5450324             0.0000000 #>          X32_Y-103..Fibroblast X29_Y-103..Fibroblast X35_Y-104..Fibroblast #> PDK4                  0.000000             0.6677265              0.000000 #> TNFRSF17              0.000000             0.0000000              0.000000 #> ICAM3                 0.000000             0.0000000              0.000000 #> FAP                   1.415887             1.0687077              1.158781 #> GZMB                  0.000000             0.0000000              0.000000 #> TSC2                  0.000000             0.0000000              0.000000 #>          X34_Y-104..Fibroblast X32_Y-104..Fibroblast X36_Y-98..Fibroblast #> PDK4                 0.0000000             0.0000000            0.5561984 #> TNFRSF17             0.0000000             0.0000000            0.0000000 #> ICAM3                0.0000000             0.0000000            0.0000000 #> FAP                  0.8270951             0.5019615            0.7548003 #> GZMB                 0.0000000             0.0000000            0.0000000 #> TSC2                 0.0000000             0.0000000            0.0000000 #>          X33_Y-101..Fibroblast X35_Y-103..Fibroblast X22_Y-86..Fibroblast #> PDK4                 0.0000000              0.000000            1.2216020 #> TNFRSF17             0.0000000              0.000000            0.0000000 #> ICAM3                0.0000000              0.000000            0.0000000 #> FAP                  0.7853872              1.545042            0.6098019 #> GZMB                 0.0000000              0.000000            0.0000000 #> TSC2                 0.0000000              0.000000            0.0000000 #>          X22_Y-87..Fibroblast X23_Y-88..Fibroblast X23_Y-90..Fibroblast #> PDK4                 1.021137             0.000000             1.412100 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  1.410842             1.263587             1.028333 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             0.000000 #>          X22_Y-88..Fibroblast X23_Y-65..Fibroblast X22_Y-65..Fibroblast #> PDK4                        0             2.559166                    0 #> TNFRSF17                    0             0.000000                    0 #> ICAM3                       0             0.000000                    0 #> FAP                         0             0.000000                    0 #> GZMB                        0             0.000000                    0 #> TSC2                        0             0.000000                    0 #>          X23_Y-98..Fibroblast X22_Y-98..Fibroblast X23_Y-99..Fibroblast #> PDK4                        0            0.4902589            0.8942256 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.0000000            0.6368415 #> GZMB                        0            0.0000000            0.0000000 #> TSC2                        0            0.4902589            0.0000000 #>          X23_Y-100..Fibroblast X22_Y-100..Fibroblast X23_Y-101..Fibroblast #> PDK4                 0.6990299                     0             1.0474466 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.9404308                     0             0.5780186 #> GZMB                 0.0000000                     0             0.0000000 #> TSC2                 0.2489430                     0             0.2489430 #>          X24_Y-101..Fibroblast X22_Y-101..Fibroblast X21_Y-102..Fibroblast #> PDK4                 1.2358184             0.8270086             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.3359787             0.3627803             0.7477251 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.3319241             0.0000000             0.0000000 #>          X22_Y-102..Fibroblast X23_Y-102..Fibroblast X22_Y-103..Fibroblast #> PDK4                 0.4543701             0.0000000             0.5948412 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.3738625             0.4984834             0.5948412 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X23_Y-103..Fibroblast X23_Y-104..Fibroblast X22_Y-104..Fibroblast #> PDK4                 0.4085632             0.0000000             0.6528718 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.3642174             0.7040090             0.0000000 #> GZMB                 0.0000000             0.3917231             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X22_Y-99..Fibroblast X21_Y-99..Fibroblast X27_Y-97..Fibroblast #> PDK4                0.5602959            0.7844143                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.4548868            0.0000000                    0 #> GZMB                0.0000000            0.0000000                    0 #> TSC2                0.5602959            0.7844143                    0 #>          X25_Y-98..Fibroblast X28_Y-98..Fibroblast X26_Y-99..Fibroblast #> PDK4                0.8853154            0.6622551            0.6899201 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.5317823            1.3567850            0.0000000 #> GZMB                0.8523389            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X29_Y-99..Fibroblast X25_Y-99..Fibroblast X28_Y-99..Fibroblast #> PDK4                 1.791880            1.4089615             2.663701 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  2.259907            0.9143074             0.000000 #> GZMB                 0.000000            0.4619123             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X24_Y-99..Fibroblast X27_Y-99..Fibroblast X24_Y-100..Fibroblast #> PDK4                0.5188800                    0             0.4658342 #> TNFRSF17            0.0000000                    0             0.0000000 #> ICAM3               0.0000000                    0             0.0000000 #> FAP                 0.9698192                    0             1.1533678 #> GZMB                0.0000000                    0             0.0000000 #> TSC2                0.0000000                    0             0.0000000 #>          X27_Y-100..Fibroblast X28_Y-100..Fibroblast X25_Y-100..Fibroblast #> PDK4                 0.3642174             0.4508308               1.38022 #> TNFRSF17             0.0000000             0.0000000               0.00000 #> ICAM3                0.0000000             0.0000000               0.00000 #> FAP                  0.3799260             0.0000000               0.00000 #> GZMB                 0.0000000             0.0000000               0.00000 #> TSC2                 0.0000000             0.0000000               0.00000 #>          X30_Y-101..Fibroblast X29_Y-101..Fibroblast X27_Y-101..Fibroblast #> PDK4                         0              1.935062             0.3613623 #> TNFRSF17                     0              0.000000             0.0000000 #> ICAM3                        0              0.000000             0.0000000 #> FAP                          0              2.322641             0.6005827 #> GZMB                         0              0.000000             0.0000000 #> TSC2                         0              0.000000             0.0000000 #>          X28_Y-101..Fibroblast X26_Y-101..Fibroblast X25_Y-101..Fibroblast #> PDK4                  0.000000             0.0000000             2.6050261 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   1.055024             0.5726165             0.9916916 #> GZMB                  0.000000             0.0000000             0.0000000 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X24_Y-102..Fibroblast X25_Y-102..Fibroblast X27_Y-102..Fibroblast #> PDK4                 1.0414329              1.047422             1.2421699 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.4136545              2.058732             0.4051736 #> GZMB                 0.0000000              0.000000             0.3838474 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X29_Y-102..Fibroblast X26_Y-102..Fibroblast X27_Y-103..Fibroblast #> PDK4                 0.6419852             0.8937872             0.3375831 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  1.8978858             0.3395378             1.2200301 #> GZMB                 0.0000000             0.4798093             0.4241228 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X25_Y-103..Fibroblast X26_Y-103..Fibroblast X24_Y-103..Fibroblast #> PDK4                 1.5160051             0.4210136             0.8516600 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.9257624             1.0546030             0.7200374 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X28_Y-103..Fibroblast X24_Y-104..Fibroblast X28_Y-104..Fibroblast #> PDK4                 0.0000000             0.6040406             0.6685549 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             1.1703600             0.6269447 #> GZMB                 0.8482456             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X25_Y-104..Fibroblast X26_Y-100..Fibroblast X28_Y-102..Fibroblast #> PDK4                 0.7248487                     0             0.0000000 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.7248487                     0             0.6574802 #> GZMB                 0.0000000                     0             0.0000000 #> TSC2                 0.0000000                     0             0.0000000 #>          X73_Y-104..Fibroblast X73_Y-105..Fibroblast X76_Y-105..Fibroblast #> PDK4                 0.0000000             0.4771045                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.4311771             0.0000000                     0 #> GZMB                 0.0000000             0.0000000                     0 #> TSC2                 0.0000000             0.0000000                     0 #>          X75_Y-105..Fibroblast X79_Y-105..Fibroblast X78_Y-105..Fibroblast #> PDK4                   0.00000              1.381168             0.6905840 #> TNFRSF17               0.00000              0.000000             0.0000000 #> ICAM3                  0.00000              0.000000             0.0000000 #> FAP                    2.98102              0.000000             0.0000000 #> GZMB                   0.00000              0.000000             0.0000000 #> TSC2                   0.00000              0.000000             0.8881096 #>          X75_Y-106..Fibroblast X72_Y-106..Fibroblast X73_Y-106..Fibroblast #> PDK4                 0.3505847             0.0000000             0.3248682 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.6318967             0.6812369             0.2439164 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.4022998             0.0000000 #>          X78_Y-106..Fibroblast X74_Y-106..Fibroblast X75_Y-107..Fibroblast #> PDK4                 0.9207787             0.6619583             0.4241228 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.0000000             1.4184817 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 1.1841461             0.0000000             0.0000000 #>          X74_Y-107..Fibroblast X73_Y-107..Fibroblast X74_Y-105..Fibroblast #> PDK4                 1.2735259             0.6002198                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.5643347             0.2695702                     0 #> GZMB                 0.0000000             0.0000000                     0 #> TSC2                 0.0000000             0.0000000                     0 #>          X72_Y-105..Fibroblast X76_Y-106..Fibroblast X63_Y-98..Fibroblast #> PDK4                 0.0000000                     0            0.4897877 #> TNFRSF17             0.0000000                     0            0.0000000 #> ICAM3                0.0000000                     0            0.0000000 #> FAP                  0.3729684                     0            0.9561386 #> GZMB                 0.0000000                     0            0.2046723 #> TSC2                 0.0000000                     0            0.0000000 #>          X61_Y-98..Fibroblast X64_Y-98..Fibroblast X66_Y-98..Fibroblast #> PDK4                        0            0.0000000                    0 #> TNFRSF17                    0            0.0000000                    0 #> ICAM3                       0            0.0000000                    0 #> FAP                         0            0.4131166                    0 #> GZMB                        0            0.0000000                    0 #> TSC2                        0            0.0000000                    0 #>          X62_Y-99..Fibroblast X63_Y-99..Fibroblast X64_Y-99..Fibroblast #> PDK4                0.9757137            0.0000000            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            0.5706292            0.2754111 #> GZMB                0.0000000            0.5141955            0.2754111 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X65_Y-99..Fibroblast X66_Y-99..Fibroblast X61_Y-99..Fibroblast #> PDK4                0.0000000            0.0000000                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.3053455            0.4208048                    0 #> GZMB                0.0000000            0.0000000                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X67_Y-99..Fibroblast X63_Y-100..Fibroblast X67_Y-100..Fibroblast #> PDK4                        0             1.1176276             0.0000000 #> TNFRSF17                    0             0.0000000             0.0000000 #> ICAM3                       0             0.0000000             0.0000000 #> FAP                         0             0.0000000             0.3825498 #> GZMB                        0             0.6125405             0.0000000 #> TSC2                        0             0.0000000             0.0000000 #>          X65_Y-100..Fibroblast X66_Y-100..Fibroblast X64_Y-100..Fibroblast #> PDK4                 0.0000000              0.000000             0.8782461 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.5322132              1.225304             0.3667859 #> GZMB                 0.0000000              0.000000             0.0000000 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X62_Y-100..Fibroblast X61_Y-101..Fibroblast X63_Y-101..Fibroblast #> PDK4                  1.257597             0.0000000                     0 #> TNFRSF17              0.000000             0.0000000                     0 #> ICAM3                 0.000000             0.0000000                     0 #> FAP                   0.000000             0.5930057                     0 #> GZMB                  1.288301             0.6711014                     0 #> TSC2                  0.000000             0.0000000                     0 #>          X65_Y-101..Fibroblast X66_Y-101..Fibroblast X62_Y-101..Fibroblast #> PDK4                 0.3484487             0.0000000             0.6762608 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.4774308             0.7055575             0.0000000 #> GZMB                 0.6006660             0.7638729             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X64_Y-101..Fibroblast X64_Y-102..Fibroblast X66_Y-102..Fibroblast #> PDK4                 0.4529834             0.0000000             0.3617165 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.6061259             0.0000000             0.3101507 #> GZMB                 0.3260504             0.5515678             0.4234501 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X63_Y-102..Fibroblast X67_Y-102..Fibroblast X62_Y-102..Fibroblast #> PDK4                 0.0000000             0.0000000             0.6395237 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  1.3726882             0.6203013             0.7078717 #> GZMB                 0.7721949             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X65_Y-102..Fibroblast X65_Y-103..Fibroblast X61_Y-103..Fibroblast #> PDK4                 0.0000000             0.0000000             0.8875293 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.4598682             0.8524111             0.0000000 #> GZMB                 0.9758506             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X60_Y-103..Fibroblast X62_Y-103..Fibroblast X63_Y-103..Fibroblast #> PDK4                 1.0362269             0.0000000             0.7760517 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.4424198             0.6880334 #> GZMB                 0.9333217             0.5188800             0.4151040 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X64_Y-103..Fibroblast X66_Y-104..Fibroblast X65_Y-98..Fibroblast #> PDK4                 0.4950648             0.0000000                    0 #> TNFRSF17             0.0000000             0.0000000                    0 #> ICAM3                0.0000000             0.0000000                    0 #> FAP                  0.7274452             0.0000000                    0 #> GZMB                 0.0000000             0.4759796                    0 #> TSC2                 0.0000000             0.0000000                    0 #>          X60_Y-99..Fibroblast X61_Y-100..Fibroblast X67_Y-101..Fibroblast #> PDK4                0.4019761                     0             0.3213693 #> TNFRSF17            0.0000000                     0             0.0000000 #> ICAM3               0.0000000                     0             0.0000000 #> FAP                 0.8454358                     0             0.9199062 #> GZMB                0.0000000                     0             0.0000000 #> TSC2                0.0000000                     0             0.0000000 #>          X60_Y-101..Fibroblast X61_Y-102..Fibroblast X66_Y-103..Fibroblast #> PDK4                 0.5409021              1.475532               0.00000 #> TNFRSF17             0.0000000              0.000000               0.00000 #> ICAM3                0.0000000              0.000000               0.00000 #> FAP                  1.1648901              1.456113               0.76717 #> GZMB                 0.9395419              0.000000               0.00000 #> TSC2                 0.0000000              0.000000               0.00000 #>          X60_Y-104..Fibroblast X22_Y-105..Fibroblast X22_Y-106..Fibroblast #> PDK4                 0.0000000                     0                     0 #> TNFRSF17             0.0000000                     0                     0 #> ICAM3                0.0000000                     0                     0 #> FAP                  0.8773159                     0                     0 #> GZMB                 0.0000000                     0                     0 #> TSC2                 0.0000000                     0                     0 #>          X23_Y-106..Fibroblast X23_Y-107..Fibroblast X23_Y-105..Fibroblast #> PDK4                 0.8941229             0.8277628                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.4303865             0.0000000                     0 #> GZMB                 0.0000000             0.0000000                     0 #> TSC2                 0.0000000             0.0000000                     0 #>          X22_Y-107..Fibroblast X70_Y-85..Fibroblast X66_Y-85..Fibroblast #> PDK4                  0.000000                    0             1.085847 #> TNFRSF17              0.000000                    0             0.000000 #> ICAM3                 0.000000                    0             0.000000 #> FAP                   1.874679                    0             1.060692 #> GZMB                  0.000000                    0             0.000000 #> TSC2                  0.000000                    0             0.000000 #>          X71_Y-86..Fibroblast X67_Y-86..Fibroblast X70_Y-86..Fibroblast #> PDK4                0.0000000                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 0.5057421                    0                    0 #> GZMB                0.0000000                    0                    0 #> TSC2                0.0000000                    0                    0 #>          X68_Y-86..Fibroblast X69_Y-86..Fibroblast X69_Y-87..Fibroblast #> PDK4                        0             1.233979             1.233979 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             0.000000             0.000000 #> GZMB                        0             0.000000             0.000000 #> TSC2                        0             0.000000             0.000000 #>          X70_Y-87..Fibroblast X71_Y-87..Fibroblast X67_Y-87..Fibroblast #> PDK4                0.0000000            0.0000000             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.3904158            0.6378785             0.000000 #> GZMB                0.2360667            0.0000000             1.504975 #> TSC2                0.0000000            0.0000000             0.000000 #>          X69_Y-88..Fibroblast X70_Y-88..Fibroblast X68_Y-88..Fibroblast #> PDK4                0.4776059            0.0000000            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.4338119            0.9381192            0.5784158 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X71_Y-88..Fibroblast X67_Y-88..Fibroblast X71_Y-89..Fibroblast #> PDK4                0.0000000            0.0000000            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.9307907            0.8473933            0.7715896 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X70_Y-89..Fibroblast X72_Y-89..Fibroblast X69_Y-89..Fibroblast #> PDK4                 1.213860            0.1774576             1.586287 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  1.108823            0.6995628             0.000000 #> GZMB                 0.000000            0.0000000             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X68_Y-89..Fibroblast X67_Y-89..Fibroblast X70_Y-90..Fibroblast #> PDK4                 0.000000            0.4661310            0.0000000 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.314511            0.9437957            1.6473947 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.4009437 #>          X68_Y-90..Fibroblast X71_Y-90..Fibroblast X69_Y-90..Fibroblast #> PDK4                 0.000000            0.0000000             0.000000 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  1.250171            0.6983464             1.170967 #> GZMB                 0.000000            0.0000000             0.000000 #> TSC2                 0.000000            0.2756488             0.000000 #>          X67_Y-90..Fibroblast X67_Y-91..Fibroblast X68_Y-91..Fibroblast #> PDK4                0.0000000                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 0.8230942                    0                    0 #> GZMB                0.0000000                    0                    0 #> TSC2                0.0000000                    0                    0 #>          X29_Y-104..Fibroblast X27_Y-104..Fibroblast X30_Y-104..Fibroblast #> PDK4                 0.4610518             0.4126741             1.7625111 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.5733768             0.0000000             0.8399009 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X24_Y-105..Fibroblast X27_Y-105..Fibroblast X25_Y-105..Fibroblast #> PDK4                 0.5418188             0.5272058             0.4311194 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.6497364             0.6588621 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X26_Y-105..Fibroblast X28_Y-105..Fibroblast X25_Y-106..Fibroblast #> PDK4                 0.4790215                     0             0.6838867 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.3726951                     0             0.0000000 #> GZMB                 0.0000000                     0             0.0000000 #> TSC2                 0.0000000                     0             0.6037167 #>          X28_Y-106..Fibroblast X26_Y-106..Fibroblast X27_Y-106..Fibroblast #> PDK4                 0.3550411             0.0000000             0.5272058 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.5013166             0.0000000             0.6497364 #> GZMB                 0.0000000             0.6248929             0.0000000 #> TSC2                 0.0000000             0.5749334             0.0000000 #>          X24_Y-106..Fibroblast X29_Y-106..Fibroblast X25_Y-107..Fibroblast #> PDK4                         0                     0             0.6809493 #> TNFRSF17                     0                     0             0.0000000 #> ICAM3                        0                     0             0.0000000 #> FAP                          0                     0             0.2729593 #> GZMB                         0                     0             0.0000000 #> TSC2                         0                     0             0.7244601 #>          X29_Y-107..Fibroblast X24_Y-107..Fibroblast X27_Y-107..Fibroblast #> PDK4                  0.000000              1.031685                     0 #> TNFRSF17              0.000000              0.000000                     0 #> ICAM3                 0.000000              0.000000                     0 #> FAP                   1.133571              0.000000                     0 #> GZMB                  0.000000              0.000000                     0 #> TSC2                  0.000000              0.000000                     0 #>          X28_Y-107..Fibroblast X26_Y-107..Fibroblast X29_Y-105..Fibroblast #> PDK4                 0.0000000             0.4549322              0.000000 #> TNFRSF17             0.0000000             0.0000000              0.000000 #> ICAM3                0.0000000             0.0000000              0.000000 #> FAP                  0.7616073             0.4549322              1.290042 #> GZMB                 0.0000000             0.6248929              0.000000 #> TSC2                 0.0000000             0.0000000              0.000000 #>          X71_Y-98..Fibroblast X68_Y-98..Fibroblast X70_Y-98..Fibroblast #> PDK4                 1.082487            0.0000000                    0 #> TNFRSF17             0.000000            0.0000000                    0 #> ICAM3                0.000000            0.0000000                    0 #> FAP                  0.000000            0.6807041                    0 #> GZMB                 0.000000            0.0000000                    0 #> TSC2                 0.000000            0.0000000                    0 #>          X72_Y-98..Fibroblast X71_Y-99..Fibroblast X68_Y-99..Fibroblast #> PDK4                0.0000000             0.947690             0.000000 #> TNFRSF17            0.0000000             0.000000             0.000000 #> ICAM3               0.0000000             0.000000             0.000000 #> FAP                 0.5379577             1.000756             1.079688 #> GZMB                0.0000000             0.000000             0.000000 #> TSC2                0.0000000             0.000000             0.000000 #>          X70_Y-99..Fibroblast X69_Y-99..Fibroblast X69_Y-100..Fibroblast #> PDK4                        0            0.0000000             0.0000000 #> TNFRSF17                    0            0.0000000             0.0000000 #> ICAM3                       0            0.0000000             0.0000000 #> FAP                         0            0.4619123             0.4384289 #> GZMB                        0            0.0000000             0.0000000 #> TSC2                        0            0.0000000             0.0000000 #>          X71_Y-100..Fibroblast X72_Y-101..Fibroblast X68_Y-101..Fibroblast #> PDK4                         0             0.0000000             0.0000000 #> TNFRSF17                     0             0.0000000             0.0000000 #> ICAM3                        0             0.0000000             0.0000000 #> FAP                          0             0.3461642             0.3961006 #> GZMB                         0             0.0000000             0.0000000 #> TSC2                         0             0.0000000             0.0000000 #>          X69_Y-101..Fibroblast X70_Y-101..Fibroblast X71_Y-101..Fibroblast #> PDK4                 0.3752483              0.000000             0.3263064 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  1.2067638              0.000000             0.6100903 #> GZMB                 0.2124953              1.053623             0.3709000 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X69_Y-102..Fibroblast X71_Y-102..Fibroblast X70_Y-102..Fibroblast #> PDK4                 0.2501655             0.0000000              0.000000 #> TNFRSF17             0.0000000             0.0000000              0.000000 #> ICAM3                0.0000000             0.0000000              0.000000 #> FAP                  1.1894307             0.6483281              0.467661 #> GZMB                 0.3520267             0.0000000              0.000000 #> TSC2                 0.0000000             0.0000000              0.000000 #>          X68_Y-102..Fibroblast X72_Y-102..Fibroblast X71_Y-103..Fibroblast #> PDK4                 0.0000000             0.2690149             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.8531293             0.7217288             0.9815842 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.2467957             0.0000000 #>          X69_Y-103..Fibroblast X68_Y-103..Fibroblast X72_Y-103..Fibroblast #> PDK4                 0.2300295             0.3578237             0.3104018 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.8086465             0.4774214             0.6055361 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.2847643 #>          X67_Y-103..Fibroblast X68_Y-104..Fibroblast X70_Y-100..Fibroblast #> PDK4                 0.0000000             0.4290067                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.6138275             1.0694706                     0 #> GZMB                 0.0000000             0.0000000                     0 #> TSC2                 0.0000000             0.0000000                     0 #>          X68_Y-100..Fibroblast X70_Y-103..Fibroblast X71_Y-104..Fibroblast #> PDK4                         0             0.0000000              0.000000 #> TNFRSF17                     0             0.0000000              0.000000 #> ICAM3                        0             0.0000000              0.000000 #> FAP                          0             0.6397457              1.014232 #> GZMB                         0             0.0000000              0.000000 #> TSC2                         0             0.0000000              0.000000 #>          X72_Y-104..Fibroblast X67_Y-104..Fibroblast X70_Y-104..Fibroblast #> PDK4                  0.000000             0.6565023             0.0000000 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   1.457654             0.0000000             0.3522851 #> GZMB                  0.000000             0.5439766             0.0000000 #> TSC2                  0.000000             0.5333267             0.0000000 #>          X69_Y-104..Fibroblast X68_Y-105..Fibroblast X70_Y-105..Fibroblast #> PDK4                 0.0000000             1.1064281             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.4874271             0.4251274             0.2167908 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X69_Y-105..Fibroblast X71_Y-105..Fibroblast X67_Y-105..Fibroblast #> PDK4                 0.5170491                     0             0.4595516 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.0000000                     0             0.6499225 #> GZMB                 0.2625233                     0             0.3757496 #> TSC2                 0.0000000                     0             0.0000000 #>          X70_Y-106..Fibroblast X69_Y-106..Fibroblast X71_Y-106..Fibroblast #> PDK4                 0.2795214             0.9442789             0.5744395 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.6616763             0.9442789             0.0000000 #> GZMB                 0.0000000             0.5250466             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X67_Y-106..Fibroblast X68_Y-106..Fibroblast X66_Y-106..Fibroblast #> PDK4                 0.8808008                     0             0.5563994 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  1.2654134                     0             1.1313216 #> GZMB                 0.0000000                     0             0.0000000 #> TSC2                 0.0000000                     0             0.0000000 #>          X67_Y-107..Fibroblast X69_Y-107..Fibroblast X71_Y-107..Fibroblast #> PDK4                 0.9039017             1.1259124             1.1944822 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  1.4051001             0.7344391             0.0000000 #> GZMB                 0.0000000             0.0000000             0.3204398 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X68_Y-107..Fibroblast X70_Y-107..Fibroblast X72_Y-107..Fibroblast #> PDK4                  0.000000             0.0000000             0.3204398 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   1.661401             0.5095399             0.3414830 #> GZMB                  1.661401             0.0000000             0.3204398 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X66_Y-105..Fibroblast X55_Y-103..Fibroblast X58_Y-104..Fibroblast #> PDK4                 0.0000000              0.000000                     0 #> TNFRSF17             0.0000000              0.000000                     0 #> ICAM3                0.0000000              0.000000                     0 #> FAP                  0.8787854              1.609473                     0 #> GZMB                 0.3131246              0.000000                     0 #> TSC2                 0.0000000              0.000000                     0 #>          X57_Y-104..Fibroblast X60_Y-105..Fibroblast X58_Y-105..Fibroblast #> PDK4                  0.000000             0.0000000             0.7313531 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   1.258688             0.7296204             0.0000000 #> GZMB                  0.000000             0.0000000             0.0000000 #> TSC2                  0.000000             0.8529205             0.0000000 #>          X59_Y-105..Fibroblast X55_Y-106..Fibroblast X58_Y-106..Fibroblast #> PDK4                  0.000000             0.0000000             1.9561606 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   1.300952             0.7359204             0.3644431 #> GZMB                  0.000000             0.0000000             0.0000000 #> TSC2                  1.302541             0.0000000             0.0000000 #>          X57_Y-106..Fibroblast X57_Y-107..Fibroblast X55_Y-107..Fibroblast #> PDK4                 0.6790135             1.4590905             0.6753700 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.4791795             0.6708513             0.4236967 #> GZMB                 0.0000000             0.0000000             0.3425466 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X59_Y-107..Fibroblast X56_Y-107..Fibroblast X58_Y-107..Fibroblast #> PDK4                  1.247696             0.9481295              1.247696 #> TNFRSF17              0.000000             0.0000000              0.000000 #> ICAM3                 0.000000             0.0000000              0.000000 #> FAP                   0.000000             0.0000000              0.000000 #> GZMB                  0.000000             0.3914818              0.000000 #> TSC2                  0.000000             0.0000000              0.000000 #>          X54_Y-107..Fibroblast X54_Y-103..Fibroblast X57_Y-103..Fibroblast #> PDK4                 1.3389322             0.2860741              0.000000 #> TNFRSF17             0.0000000             0.0000000              0.000000 #> ICAM3                0.0000000             0.0000000              0.000000 #> FAP                  0.8473933             1.0981142              1.055542 #> GZMB                 0.0000000             0.0000000              0.000000 #> TSC2                 0.0000000             0.0000000              0.000000 #>          X55_Y-104..Fibroblast X59_Y-104..Fibroblast X57_Y-105..Fibroblast #> PDK4                  0.000000                     0                     0 #> TNFRSF17              0.000000                     0                     0 #> ICAM3                 0.000000                     0                     0 #> FAP                   1.251645                     0                     0 #> GZMB                  0.000000                     0                     0 #> TSC2                  0.000000                     0                     0 #>          X61_Y-105..Fibroblast X56_Y-105..Fibroblast X54_Y-105..Fibroblast #> PDK4                  0.000000              0.000000             0.3266462 #> TNFRSF17              0.000000              0.000000             0.0000000 #> ICAM3                 0.000000              0.000000             0.0000000 #> FAP                   1.014841              1.785589             0.8799770 #> GZMB                  0.000000              0.000000             0.0000000 #> TSC2                  0.000000              0.000000             0.0000000 #>          X56_Y-106..Fibroblast X59_Y-106..Fibroblast X54_Y-106..Fibroblast #> PDK4                 0.5566477             0.9287627             0.4498868 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.5415371             1.0469555             0.9605672 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X61_Y-104..Fibroblast X63_Y-104..Fibroblast X64_Y-104..Fibroblast #> PDK4                         0             0.6609866             0.6767955 #> TNFRSF17                     0             0.0000000             0.0000000 #> ICAM3                        0             0.0000000             0.0000000 #> FAP                          0             0.6497061             1.3436254 #> GZMB                         0             0.0000000             0.0000000 #> TSC2                         0             0.0000000             0.0000000 #>          X62_Y-104..Fibroblast X65_Y-105..Fibroblast X64_Y-105..Fibroblast #> PDK4                  1.132458                     0              2.129786 #> TNFRSF17              0.000000                     0              0.000000 #> ICAM3                 0.000000                     0              0.000000 #> FAP                   2.348338                     0              1.624079 #> GZMB                  0.000000                     0              0.000000 #> TSC2                  0.000000                     0              0.000000 #>          X62_Y-105..Fibroblast X64_Y-106..Fibroblast X63_Y-106..Fibroblast #> PDK4                 0.7865817             0.8982001                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.7173277             0.0000000                     0 #> GZMB                 0.0000000             0.0000000                     0 #> TSC2                 0.0000000             0.0000000                     0 #>          X65_Y-106..Fibroblast X63_Y-107..Fibroblast X64_Y-107..Fibroblast #> PDK4                 0.6641021                     0             0.4427347 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.6641021                     0             0.4427347 #> GZMB                 0.0000000                     0             0.0000000 #> TSC2                 0.0000000                     0             0.0000000 #>          X61_Y-107..Fibroblast X65_Y-107..Fibroblast X66_Y-107..Fibroblast #> PDK4                  1.718205             0.5312817             0.4769138 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             0.5312817             0.5327587 #> GZMB                  0.000000             0.0000000             0.0000000 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X65_Y-104..Fibroblast X63_Y-105..Fibroblast X61_Y-106..Fibroblast #> PDK4                  0.000000             0.8377341              1.590443 #> TNFRSF17              0.000000             0.0000000              0.000000 #> ICAM3                 0.000000             0.0000000              0.000000 #> FAP                   1.436638             0.7490629              0.000000 #> GZMB                  0.000000             0.0000000              0.000000 #> TSC2                  0.000000             0.0000000              1.264223 #>          X62_Y-106..Fibroblast X53_Y-103..Fibroblast X52_Y-104..Fibroblast #> PDK4                  1.593129                     0             0.2794582 #> TNFRSF17              0.000000                     0             0.0000000 #> ICAM3                 0.000000                     0             0.0000000 #> FAP                   0.000000                     0             0.8099156 #> GZMB                  0.000000                     0             0.1900079 #> TSC2                  0.000000                     0             0.0000000 #>          X50_Y-104..Fibroblast X53_Y-104..Fibroblast X51_Y-104..Fibroblast #> PDK4                 0.3821549             0.0000000             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.6334233             0.3182058             0.8658485 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X49_Y-104..Fibroblast X54_Y-104..Fibroblast X53_Y-105..Fibroblast #> PDK4                  0.000000             0.3266462             0.5531283 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   1.464816             0.8551049             0.2386544 #> GZMB                  0.000000             0.0000000             0.0000000 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X51_Y-105..Fibroblast X48_Y-105..Fibroblast X49_Y-105..Fibroblast #> PDK4                 0.3417678             0.9575203             0.3641700 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.3936740             0.3565519             0.4357857 #> GZMB                 0.0000000             0.3663438             0.4477535 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X52_Y-105..Fibroblast X50_Y-105..Fibroblast X51_Y-106..Fibroblast #> PDK4                 0.9839726             0.8866256             0.4272098 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.8409624             0.0000000             0.4920925 #> GZMB                 0.3325138             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X49_Y-106..Fibroblast X53_Y-106..Fibroblast X48_Y-106..Fibroblast #> PDK4                         0              0.000000             0.3529666 #> TNFRSF17                     0              0.000000             0.0000000 #> ICAM3                        0              0.000000             0.0000000 #> FAP                          0              1.573342             1.5057273 #> GZMB                         0              0.000000             0.4893729 #> TSC2                         0              0.000000             0.0000000 #>          X52_Y-106..Fibroblast X52_Y-107..Fibroblast X49_Y-107..Fibroblast #> PDK4                 0.0000000             0.0000000              0.000000 #> TNFRSF17             0.0000000             0.0000000              0.000000 #> ICAM3                0.0000000             0.0000000              0.000000 #> FAP                  0.8236342             0.7602777              2.118001 #> GZMB                 0.0000000             0.3095669              0.000000 #> TSC2                 0.0000000             0.0000000              0.000000 #>          X53_Y-107..Fibroblast X51_Y-107..Fibroblast X52_Y-103..Fibroblast #> PDK4                 0.0000000             0.7140233             0.5828124 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  1.4000349             1.0101741             0.8594771 #> GZMB                 0.5030463             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X55_Y-105..Fibroblast X48_Y-107..Fibroblast X50_Y-107..Fibroblast #> PDK4                         0             0.4412083              1.428047 #> TNFRSF17                     0             0.0000000              0.000000 #> ICAM3                        0             0.0000000              0.000000 #> FAP                          0             1.9157724              1.975818 #> GZMB                         0             0.6117162              0.000000 #> TSC2                         0             0.0000000              0.000000 #>          X36_Y-103..Fibroblast X33_Y-104..Fibroblast X31_Y-104..Fibroblast #> PDK4                         0                     0              0.000000 #> TNFRSF17                     0                     0              0.000000 #> ICAM3                        0                     0              0.000000 #> FAP                          0                     0              1.790846 #> GZMB                         0                     0              0.000000 #> TSC2                         0                     0              0.000000 #>          X33_Y-105..Fibroblast X31_Y-105..Fibroblast X35_Y-105..Fibroblast #> PDK4                  1.014207             0.5568369              0.000000 #> TNFRSF17              0.000000             0.0000000              0.000000 #> ICAM3                 0.000000             0.0000000              0.000000 #> FAP                   0.000000             0.6434957              1.849044 #> GZMB                  0.000000             0.0000000              1.849044 #> TSC2                  0.000000             0.0000000              0.000000 #>          X30_Y-105..Fibroblast X32_Y-105..Fibroblast X34_Y-105..Fibroblast #> PDK4                  1.497186              1.170192              0.434660 #> TNFRSF17              0.000000              0.000000              0.000000 #> ICAM3                 0.000000              0.000000              0.000000 #> FAP                   0.000000              0.000000              1.018103 #> GZMB                  0.000000              0.000000              0.000000 #> TSC2                  0.000000              0.000000              0.000000 #>          X35_Y-106..Fibroblast X34_Y-106..Fibroblast X33_Y-106..Fibroblast #> PDK4                 0.6721578              0.924217             0.6085239 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.6331628              1.379874             0.0000000 #> GZMB                 0.0000000              0.000000             0.0000000 #> TSC2                 0.4241744              0.000000             0.0000000 #>          X31_Y-106..Fibroblast X32_Y-106..Fibroblast X30_Y-106..Fibroblast #> PDK4                 0.6763057             1.1156949                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.8527935             0.3851815                     0 #> GZMB                 0.0000000             0.3234717                     0 #> TSC2                 0.0000000             0.0000000                     0 #>          X32_Y-107..Fibroblast X31_Y-107..Fibroblast X33_Y-107..Fibroblast #> PDK4                 0.0000000             0.4305392             0.4413050 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.7749157             0.0000000             0.5508222 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X34_Y-107..Fibroblast X30_Y-107..Fibroblast X42_Y-103..Fibroblast #> PDK4                 0.0000000                     0             0.2370491 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.6790335                     0             1.2560423 #> GZMB                 0.0000000                     0             0.0000000 #> TSC2                 0.0000000                     0             0.1985613 #>          X42_Y-104..Fibroblast X45_Y-104..Fibroblast X46_Y-104..Fibroblast #> PDK4                 0.6912709                     0              1.950381 #> TNFRSF17             0.0000000                     0              0.000000 #> ICAM3                0.0000000                     0              0.000000 #> FAP                  0.7746102                     0              2.569763 #> GZMB                 0.0000000                     0              0.000000 #> TSC2                 0.0000000                     0              0.000000 #>          X42_Y-105..Fibroblast X47_Y-105..Fibroblast X47_Y-106..Fibroblast #> PDK4                 1.4404206             0.6465605             0.3689192 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.4296007             0.0000000             0.5596204 #> GZMB                 0.5974709             0.0000000             0.0000000 #> TSC2                 0.4296007             0.0000000             0.0000000 #>          X42_Y-106..Fibroblast X45_Y-106..Fibroblast X46_Y-106..Fibroblast #> PDK4                 0.6703188             0.0000000             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             1.8758498             1.7271693 #> GZMB                 0.0000000             0.5663194             0.3089015 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X43_Y-106..Fibroblast X47_Y-107..Fibroblast X46_Y-107..Fibroblast #> PDK4                         0             0.8632259              0.000000 #> TNFRSF17                     0             0.0000000              0.000000 #> ICAM3                        0             0.0000000              0.000000 #> FAP                          0             0.9941710              1.662983 #> GZMB                         0             0.0000000              0.000000 #> TSC2                         0             0.0000000              0.000000 #>          X42_Y-107..Fibroblast X44_Y-107..Fibroblast X45_Y-107..Fibroblast #> PDK4                 0.7691868             0.5872100             0.5666809 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.6110001             0.0000000             2.3147356 #> GZMB                 0.0000000             0.5266862             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X43_Y-107..Fibroblast X58_Y-98..Fibroblast X56_Y-98..Fibroblast #> PDK4                 0.7046519            0.0000000            0.5984861 #> TNFRSF17             0.0000000            0.0000000            0.0000000 #> ICAM3                0.0000000            0.0000000            0.0000000 #> FAP                  0.5939217            0.8879225            1.9539279 #> GZMB                 0.6320235            0.0000000            0.3942069 #> TSC2                 0.0000000            0.0000000            0.0000000 #>          X58_Y-99..Fibroblast X59_Y-99..Fibroblast X54_Y-99..Fibroblast #> PDK4                        0            0.0000000            0.3887992 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            1.1806558            0.9301350 #> GZMB                        0            0.0000000            0.0000000 #> TSC2                        0            0.3226325            0.0000000 #>          X56_Y-99..Fibroblast X55_Y-99..Fibroblast X60_Y-100..Fibroblast #> PDK4                0.0000000            0.1814396             0.4613844 #> TNFRSF17            0.0000000            0.0000000             0.0000000 #> ICAM3               0.0000000            0.0000000             0.0000000 #> FAP                 0.6256507            0.6114199             0.0000000 #> GZMB                0.0000000            0.2483568             0.0000000 #> TSC2                0.0000000            0.0000000             0.0000000 #>          X56_Y-100..Fibroblast X59_Y-100..Fibroblast X54_Y-100..Fibroblast #> PDK4                 1.0115501             0.0000000             0.4005498 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.8792241             0.6887931             0.0000000 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.3351743 #>          X55_Y-101..Fibroblast X56_Y-101..Fibroblast X54_Y-101..Fibroblast #> PDK4                 0.3890193             0.9487431                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.6372311             0.3330229                     0 #> GZMB                 0.0000000             0.0000000                     0 #> TSC2                 0.5116966             0.0000000                     0 #>          X57_Y-101..Fibroblast X59_Y-101..Fibroblast X58_Y-101..Fibroblast #> PDK4                 0.0000000              1.285477             0.7712864 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.8229633              0.000000             0.0000000 #> GZMB                 0.0000000              0.000000             0.0000000 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X56_Y-102..Fibroblast X55_Y-102..Fibroblast X59_Y-102..Fibroblast #> PDK4                 0.0000000             0.3501174               0.00000 #> TNFRSF17             0.0000000             0.0000000               0.00000 #> ICAM3                0.0000000             0.0000000               0.00000 #> FAP                  0.3746507             0.0000000               1.73859 #> GZMB                 0.0000000             0.0000000               0.00000 #> TSC2                 0.0000000             0.4605269               0.00000 #>          X60_Y-102..Fibroblast X58_Y-102..Fibroblast X54_Y-102..Fibroblast #> PDK4                 0.6908180              0.000000              0.000000 #> TNFRSF17             0.0000000              0.000000              0.000000 #> ICAM3                0.0000000              0.000000              0.000000 #> FAP                  1.1590600              1.337879              1.105034 #> GZMB                 0.6222145              0.000000              1.105034 #> TSC2                 0.0000000              0.000000              0.000000 #>          X56_Y-103..Fibroblast X59_Y-103..Fibroblast X58_Y-103..Fibroblast #> PDK4                  0.000000             0.0000000             0.7607077 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   1.784523             0.7432998             0.8919597 #> GZMB                  0.000000             0.0000000             0.0000000 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X56_Y-104..Fibroblast X54_Y-98..Fibroblast X57_Y-99..Fibroblast #> PDK4                  0.000000            0.5443189                    0 #> TNFRSF17              0.000000            0.0000000                    0 #> ICAM3                 0.000000            0.0000000                    0 #> FAP                   2.638293            1.8809826                    0 #> GZMB                  0.000000            0.0000000                    0 #> TSC2                  0.000000            0.0000000                    0 #>          X55_Y-100..Fibroblast X58_Y-100..Fibroblast X57_Y-100..Fibroblast #> PDK4                         0              0.000000              0.000000 #> TNFRSF17                     0              0.000000              0.000000 #> ICAM3                        0              0.000000              0.000000 #> FAP                          0              1.888032              0.944016 #> GZMB                         0              0.000000              0.000000 #> TSC2                         0              0.000000              0.000000 #>          X57_Y-102..Fibroblast X39_Y-97..Fibroblast X40_Y-97..Fibroblast #> PDK4                  0.000000            0.5372937              0.00000 #> TNFRSF17              0.000000            0.0000000              0.00000 #> ICAM3                 0.000000            0.0000000              0.00000 #> FAP                   2.006819            0.2607364              1.82414 #> GZMB                  0.000000            0.0000000              0.00000 #> TSC2                  0.000000            0.0000000              0.00000 #>          X38_Y-97..Fibroblast X37_Y-97..Fibroblast X41_Y-97..Fibroblast #> PDK4                1.1456085            0.3097464            0.2411444 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            1.6032776            0.2043813 #> GZMB                0.2207893            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.2043813 #>          X40_Y-98..Fibroblast X41_Y-98..Fibroblast X42_Y-98..Fibroblast #> PDK4                 0.000000            0.3598160            0.6204630 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.345899            0.3852543            0.3845934 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X39_Y-98..Fibroblast X37_Y-98..Fibroblast X38_Y-98..Fibroblast #> PDK4                0.0000000            0.7682732            0.7783198 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.8732760            1.1496469            0.0000000 #> GZMB                0.3108228            0.0000000            0.3412198 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X41_Y-99..Fibroblast X37_Y-99..Fibroblast X39_Y-99..Fibroblast #> PDK4                 0.000000            1.1369921            0.2759209 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.286145            0.2701157            1.3011467 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X40_Y-99..Fibroblast X36_Y-99..Fibroblast X38_Y-99..Fibroblast #> PDK4                0.2232225             1.471354              1.06593 #> TNFRSF17            0.0000000             0.000000              0.00000 #> ICAM3               0.0000000             0.000000              0.00000 #> FAP                 1.3941211             2.407496              0.00000 #> GZMB                0.0000000             0.000000              0.00000 #> TSC2                0.1523141             0.000000              0.00000 #>          X42_Y-99..Fibroblast X40_Y-100..Fibroblast X41_Y-100..Fibroblast #> PDK4                 0.000000             0.1944345             0.0000000 #> TNFRSF17             0.000000             0.0000000             0.0000000 #> ICAM3                0.000000             0.0000000             0.0000000 #> FAP                  1.350857             0.5116129             0.5246889 #> GZMB                 0.000000             0.0000000             0.0000000 #> TSC2                 0.000000             0.0000000             0.0000000 #>          X37_Y-100..Fibroblast X42_Y-100..Fibroblast X39_Y-100..Fibroblast #> PDK4                 0.3650405             0.3926936             1.2719844 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.8937394             1.4816009             0.3997759 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X38_Y-100..Fibroblast X37_Y-101..Fibroblast X38_Y-101..Fibroblast #> PDK4                 0.8854436              1.053763              1.144211 #> TNFRSF17             0.0000000              0.000000              0.000000 #> ICAM3                0.0000000              0.000000              0.000000 #> FAP                  0.4241228              1.567853              1.407179 #> GZMB                 0.0000000              0.000000              0.000000 #> TSC2                 0.0000000              0.000000              0.000000 #>          X40_Y-101..Fibroblast X41_Y-101..Fibroblast X36_Y-101..Fibroblast #> PDK4                  0.000000             0.0000000              3.510576 #> TNFRSF17              0.000000             0.0000000              0.000000 #> ICAM3                 0.000000             0.0000000              0.000000 #> FAP                   1.249052             0.3542951              0.000000 #> GZMB                  0.000000             0.0000000              0.000000 #> TSC2                  0.000000             0.0000000              0.000000 #>          X39_Y-101..Fibroblast X38_Y-102..Fibroblast X40_Y-102..Fibroblast #> PDK4                 0.0000000             0.2674121             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.3351546             0.8423806             1.6251646 #> GZMB                 0.0000000             0.0000000             0.4383548 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X39_Y-102..Fibroblast X42_Y-102..Fibroblast X37_Y-102..Fibroblast #> PDK4                 0.2005591             0.3555737             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  1.4228159             1.7278646             1.3667495 #> GZMB                 0.0000000             0.0000000             0.4866736 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X41_Y-102..Fibroblast X41_Y-103..Fibroblast X39_Y-103..Fibroblast #> PDK4                 0.0000000             0.1990304             0.1856005 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.8920659             0.5981618             0.9403305 #> GZMB                 0.0000000             0.0000000             0.1929639 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X37_Y-103..Fibroblast X38_Y-103..Fibroblast X40_Y-103..Fibroblast #> PDK4                 0.0000000             0.0000000             0.2985456 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  2.5825854             0.2722271             0.8883903 #> GZMB                 0.4866736             0.2806748             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X38_Y-104..Fibroblast X37_Y-104..Fibroblast X41_Y-104..Fibroblast #> PDK4                 0.0000000             0.0000000             0.5760591 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.5609909             0.8309044             0.6146467 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X36_Y-104..Fibroblast X65_Y-85..Fibroblast X64_Y-85..Fibroblast #> PDK4                 0.0000000             1.409273             0.000000 #> TNFRSF17             0.0000000             0.000000             0.000000 #> ICAM3                0.0000000             0.000000             0.000000 #> FAP                  0.5666809             0.000000             4.348158 #> GZMB                 0.0000000             0.000000             0.000000 #> TSC2                 0.0000000             0.000000             0.000000 #>          X61_Y-86..Fibroblast X62_Y-86..Fibroblast X63_Y-86..Fibroblast #> PDK4                0.4168962            0.5084773                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 1.0010197            0.0000000                    0 #> GZMB                0.0000000            0.0000000                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X65_Y-86..Fibroblast X66_Y-86..Fibroblast X64_Y-86..Fibroblast #> PDK4                        0            0.4818724             1.953812 #> TNFRSF17                    0            0.0000000             0.000000 #> ICAM3                       0            0.0000000             0.000000 #> FAP                         0            1.0606918             1.953812 #> GZMB                        0            0.0000000             0.000000 #> TSC2                        0            0.0000000             0.000000 #>          X62_Y-87..Fibroblast X63_Y-87..Fibroblast X64_Y-87..Fibroblast #> PDK4                0.5084773            0.0000000            0.7815246 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.4572018            0.7452447            1.6874913 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X66_Y-87..Fibroblast X61_Y-87..Fibroblast X65_Y-87..Fibroblast #> PDK4                0.0000000                    0             0.000000 #> TNFRSF17            0.0000000                    0             0.000000 #> ICAM3               0.0000000                    0             0.000000 #> FAP                 0.7718556                    0             1.707656 #> GZMB                0.8446409                    0             0.000000 #> TSC2                0.0000000                    0             0.000000 #>          X66_Y-88..Fibroblast X62_Y-88..Fibroblast X64_Y-88..Fibroblast #> PDK4                 0.000000             0.000000            0.0000000 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  2.103003             1.371605            0.9373394 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X65_Y-89..Fibroblast X61_Y-89..Fibroblast X63_Y-89..Fibroblast #> PDK4                        0                    0             0.000000 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             1.371605 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X62_Y-90..Fibroblast X64_Y-90..Fibroblast X66_Y-90..Fibroblast #> PDK4                0.4259954            0.0000000                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 1.7622581            0.6837415                    0 #> GZMB                0.0000000            0.0000000                    0 #> TSC2                0.0000000            0.6837415                    0 #>          X65_Y-90..Fibroblast X61_Y-91..Fibroblast X63_Y-91..Fibroblast #> PDK4                        0             0.000000             0.000000 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             1.692026             1.054471 #> GZMB                        0             0.000000             0.000000 #> TSC2                        0             0.000000             0.000000 #>          X62_Y-89..Fibroblast X63_Y-90..Fibroblast X37_Y-91..Fibroblast #> PDK4                 0.000000                    0             1.010240 #> TNFRSF17             0.000000                    0             0.000000 #> ICAM3                0.000000                    0             0.000000 #> FAP                  2.057408                    0             1.498999 #> GZMB                 0.000000                    0             0.000000 #> TSC2                 0.000000                    0             0.000000 #>          X38_Y-92..Fibroblast X40_Y-92..Fibroblast X37_Y-92..Fibroblast #> PDK4                        0             0.000000             1.319486 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             1.247196             1.654283 #> GZMB                        0             0.000000             0.000000 #> TSC2                        0             0.000000             0.000000 #>          X39_Y-92..Fibroblast X41_Y-92..Fibroblast X38_Y-93..Fibroblast #> PDK4                0.2370491            0.0000000            1.2419922 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.4715580            0.6764174            0.2263061 #> GZMB                0.2227347            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X39_Y-93..Fibroblast X41_Y-93..Fibroblast X37_Y-93..Fibroblast #> PDK4                1.4442007            0.2722967            0.3358098 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.7154197            1.3546102            1.6150238 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X40_Y-93..Fibroblast X40_Y-94..Fibroblast X41_Y-94..Fibroblast #> PDK4                0.8909659            1.0876814             0.285978 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.3911192            0.7261361             1.275212 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X39_Y-94..Fibroblast X37_Y-94..Fibroblast X39_Y-95..Fibroblast #> PDK4                0.8243494            1.9278187            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.8574611            0.7794684            0.7989645 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X38_Y-95..Fibroblast X41_Y-95..Fibroblast X37_Y-95..Fibroblast #> PDK4                0.9025506            0.0000000            0.7036985 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.5780670            0.6475236            0.7364944 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X40_Y-95..Fibroblast X38_Y-96..Fibroblast X36_Y-96..Fibroblast #> PDK4                0.3214652            0.7234609            0.9188316 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.4093807            0.4511217            0.7971641 #> GZMB                0.2363980            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X40_Y-96..Fibroblast X39_Y-96..Fibroblast X41_Y-96..Fibroblast #> PDK4                0.8882202            0.4598756            0.8220362 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.4387050            0.3893389            0.9819880 #> GZMB                0.2000291            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.2043813 #>          X37_Y-96..Fibroblast X38_Y-94..Fibroblast X40_Y-104..Fibroblast #> PDK4                0.1929937             1.089707               0.00000 #> TNFRSF17            0.0000000             0.000000               0.00000 #> ICAM3               0.0000000             0.000000               0.00000 #> FAP                 0.7202887             0.526006               1.51973 #> GZMB                0.2636029             0.000000               0.00000 #> TSC2                0.0000000             0.000000               0.00000 #>          X39_Y-104..Fibroblast X41_Y-105..Fibroblast X39_Y-105..Fibroblast #> PDK4                 0.0000000             0.8731872             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.6544894             0.8473021             0.4363262 #> GZMB                 0.0000000             0.0000000             0.3914733 #> TSC2                 0.0000000             0.2313234             0.0000000 #>          X36_Y-105..Fibroblast X38_Y-105..Fibroblast X37_Y-105..Fibroblast #> PDK4                 0.0000000             0.0000000             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.9245222             0.5881560             0.4521457 #> GZMB                 0.9245222             0.3914733             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X40_Y-105..Fibroblast X37_Y-106..Fibroblast X40_Y-106..Fibroblast #> PDK4                 0.2887552              0.000000              0.000000 #> TNFRSF17             0.0000000              0.000000              0.000000 #> ICAM3                0.0000000              0.000000              0.000000 #> FAP                  0.7281185              1.446933              1.319699 #> GZMB                 0.0000000              0.000000              0.000000 #> TSC2                 0.0000000              0.000000              0.000000 #>          X41_Y-106..Fibroblast X39_Y-106..Fibroblast X38_Y-106..Fibroblast #> PDK4                 0.6445026             0.0000000              0.000000 #> TNFRSF17             0.0000000             0.0000000              0.000000 #> ICAM3                0.0000000             0.0000000              0.000000 #> FAP                  0.4768407             0.7137668              1.942406 #> GZMB                 0.0000000             0.0000000              0.000000 #> TSC2                 0.0000000             0.0000000              0.000000 #>          X36_Y-106..Fibroblast X41_Y-107..Fibroblast X40_Y-107..Fibroblast #> PDK4                  0.000000              1.956842              0.000000 #> TNFRSF17              0.000000              0.000000              0.000000 #> ICAM3                 0.000000              0.000000              0.000000 #> FAP                   2.118284              1.170488              0.887141 #> GZMB                  0.000000              0.000000              0.000000 #> TSC2                  0.000000              0.000000              0.000000 #>          X37_Y-107..Fibroblast X38_Y-107..Fibroblast X39_Y-107..Fibroblast #> PDK4                  0.000000               0.00000              0.000000 #> TNFRSF17              0.000000               0.00000              0.000000 #> ICAM3                 0.000000               0.00000              0.000000 #> FAP                   2.813882               1.30725              0.419282 #> GZMB                  0.000000               0.00000              0.000000 #> TSC2                  0.000000               0.00000              0.000000 #>          X36_Y-107..Fibroblast X49_Y-85..Fibroblast X51_Y-85..Fibroblast #> PDK4                  3.287401             1.964528                    0 #> TNFRSF17              0.000000             0.000000                    0 #> ICAM3                 0.000000             0.000000                    0 #> FAP                   0.000000             0.000000                    0 #> GZMB                  0.000000             0.000000                    0 #> TSC2                  0.000000             0.000000                    0 #>          X51_Y-86..Fibroblast X52_Y-86..Fibroblast X53_Y-86..Fibroblast #> PDK4                 0.000000            0.7636036            0.5303319 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  3.723464            1.6716764            1.7901869 #> GZMB                 0.000000            0.4054935            0.6082402 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X54_Y-86..Fibroblast X52_Y-87..Fibroblast X53_Y-87..Fibroblast #> PDK4                0.0000000            0.4613051                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.5867032            0.4323123                    0 #> GZMB                0.0000000            0.0000000                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X50_Y-87..Fibroblast X51_Y-87..Fibroblast X54_Y-87..Fibroblast #> PDK4                 1.631458            0.0000000            0.0000000 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.000000            0.8646246            0.7466774 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X49_Y-88..Fibroblast X52_Y-88..Fibroblast X54_Y-88..Fibroblast #> PDK4                0.3350555            0.0000000             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.5987128            0.9293772             1.455173 #> GZMB                0.1881227            0.0000000             0.000000 #> TSC2                0.2730116            0.4691772             0.000000 #>          X50_Y-88..Fibroblast X52_Y-89..Fibroblast X49_Y-89..Fibroblast #> PDK4                0.8619906            0.0000000             1.079935 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.3589600            0.5552850             1.101077 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.2232977             0.000000 #>          X51_Y-89..Fibroblast X50_Y-89..Fibroblast X53_Y-89..Fibroblast #> PDK4                0.1969965             0.603127            0.6208967 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.2103396             0.414826            0.8974081 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.1838922             0.000000            0.0000000 #>          X54_Y-89..Fibroblast X53_Y-90..Fibroblast X52_Y-90..Fibroblast #> PDK4                 0.000000            0.8084972            0.3035048 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  1.422871            0.5386182            1.1155610 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.1713139            0.0000000 #>          X50_Y-90..Fibroblast X55_Y-90..Fibroblast X51_Y-90..Fibroblast #> PDK4                0.6771618             0.000000            0.0000000 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 1.2511196             1.043348            0.5953746 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.0000000 #>          X54_Y-90..Fibroblast X49_Y-90..Fibroblast X51_Y-88..Fibroblast #> PDK4                0.6006019             0.000000             0.000000 #> TNFRSF17            0.0000000             0.000000             0.000000 #> ICAM3               0.0000000             0.000000             0.000000 #> FAP                 0.5617244             1.148495             1.239170 #> GZMB                0.0000000             0.000000             0.000000 #> TSC2                0.0000000             0.000000             1.146598 #>          X53_Y-88..Fibroblast X55_Y-85..Fibroblast X59_Y-86..Fibroblast #> PDK4                        0            1.7344996                    0 #> TNFRSF17                    0            0.0000000                    0 #> ICAM3                       0            0.0000000                    0 #> FAP                         0            0.0000000                    0 #> GZMB                        0            0.7868097                    0 #> TSC2                        0            0.0000000                    0 #>          X60_Y-86..Fibroblast X55_Y-86..Fibroblast X56_Y-86..Fibroblast #> PDK4                0.7740249            0.0000000             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.6916996            0.7210869             1.507364 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X57_Y-86..Fibroblast X57_Y-87..Fibroblast X56_Y-87..Fibroblast #> PDK4                0.7008988            0.0000000             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.8664945            0.7685865             1.572555 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X60_Y-87..Fibroblast X55_Y-87..Fibroblast X55_Y-88..Fibroblast #> PDK4                 2.515805            0.4297868             0.000000 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  0.000000            1.4753617             1.157027 #> GZMB                 0.000000            0.0000000             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X57_Y-88..Fibroblast X58_Y-88..Fibroblast X59_Y-89..Fibroblast #> PDK4                0.6636118            0.9290565             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 1.0100421            0.6454725             2.007925 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X58_Y-89..Fibroblast X57_Y-89..Fibroblast X56_Y-89..Fibroblast #> PDK4                 2.805053            0.9350176             0.845326 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  3.467481            1.9972311             1.427675 #> GZMB                 2.805053            0.9350176             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X55_Y-89..Fibroblast X60_Y-89..Fibroblast X56_Y-90..Fibroblast #> PDK4                0.8169405            0.9188316            0.4830434 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.6787461            0.7938436            1.4550970 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X57_Y-90..Fibroblast X60_Y-90..Fibroblast X58_Y-90..Fibroblast #> PDK4                0.8016631            1.6852616            0.8016631 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.8102795            1.7632592            1.7712671 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.9968292            0.0000000 #>          X58_Y-91..Fibroblast X55_Y-91..Fibroblast X59_Y-91..Fibroblast #> PDK4                 1.002079            0.0000000             1.839541 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  2.214084            0.7303435             0.000000 #> GZMB                 0.000000            0.0000000             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X58_Y-86..Fibroblast X59_Y-88..Fibroblast X55_Y-64..Fibroblast #> PDK4                 2.803595             0.000000                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  3.465978             1.424201                    0 #> GZMB                 0.000000             0.000000                    0 #> TSC2                 0.000000             0.000000                    0 #>          X56_Y-65..Fibroblast X55_Y-65..Fibroblast X57_Y-65..Fibroblast #> PDK4                0.9393739            0.4769138             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.9393739            0.0000000             1.760742 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X55_Y-66..Fibroblast X57_Y-66..Fibroblast X58_Y-66..Fibroblast #> PDK4                        0             0.000000             0.000000 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             1.757042             1.148884 #> GZMB                        0             0.000000             0.000000 #> TSC2                        0             0.000000             0.000000 #>          X71_Y-64..Fibroblast X73_Y-64..Fibroblast X71_Y-65..Fibroblast #> PDK4                 1.889804            0.0000000             1.367809 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  1.282947            0.0000000             1.837294 #> GZMB                 0.000000            0.8856529             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X67_Y-66..Fibroblast X73_Y-66..Fibroblast X72_Y-66..Fibroblast #> PDK4                 0.000000                    0                    0 #> TNFRSF17             0.000000                    0                    0 #> ICAM3                0.000000                    0                    0 #> FAP                  1.763229                    0                    0 #> GZMB                 0.000000                    0                    0 #> TSC2                 0.000000                    0                    0 #>          X72_Y-67..Fibroblast X72_Y-65..Fibroblast X52_Y-97..Fibroblast #> PDK4                0.0000000             0.000000              0.00000 #> TNFRSF17            0.0000000             0.000000              0.00000 #> ICAM3               0.0000000             0.000000              0.00000 #> FAP                 0.0000000             2.217389              1.99372 #> GZMB                0.0000000             0.000000              0.00000 #> TSC2                0.9994398             0.000000              0.00000 #>          X48_Y-98..Fibroblast X49_Y-98..Fibroblast X49_Y-99..Fibroblast #> PDK4                 0.000000            0.1895017            0.0000000 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  2.241371            0.4701419            0.2202963 #> GZMB                 0.000000            0.0000000            0.3417728 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X50_Y-99..Fibroblast X53_Y-99..Fibroblast X51_Y-99..Fibroblast #> PDK4                0.0000000            0.7564669            0.3656766 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 1.0701325            0.7298883            1.6788518 #> GZMB                0.4936718            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X52_Y-99..Fibroblast X51_Y-100..Fibroblast X53_Y-100..Fibroblast #> PDK4                0.3782335             0.7313531             0.5403655 #> TNFRSF17            0.0000000             0.0000000             0.0000000 #> ICAM3               0.0000000             0.0000000             0.0000000 #> FAP                 1.1163429             1.1768774             0.2432067 #> GZMB                0.0000000             0.0000000             0.0000000 #> TSC2                0.0000000             0.0000000             0.2234495 #>          X49_Y-100..Fibroblast X48_Y-100..Fibroblast X50_Y-100..Fibroblast #> PDK4                 1.2291951             0.5863666             0.5233383 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.4926147             1.1318731             0.4733341 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X52_Y-100..Fibroblast X49_Y-101..Fibroblast X50_Y-101..Fibroblast #> PDK4                 0.8713036             0.8840701             0.8722305 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.4222411             1.7059854 #> GZMB                 0.3456401             0.4834360             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X52_Y-101..Fibroblast X48_Y-101..Fibroblast X53_Y-101..Fibroblast #> PDK4                 0.6150735             1.3859546              1.573999 #> TNFRSF17             0.0000000             0.0000000              0.000000 #> ICAM3                0.0000000             0.0000000              0.000000 #> FAP                  0.5295958             0.0000000              0.000000 #> GZMB                 0.0000000             0.3760058              0.000000 #> TSC2                 0.0000000             0.3842776              0.000000 #>          X53_Y-102..Fibroblast X49_Y-102..Fibroblast X48_Y-102..Fibroblast #> PDK4                 0.9837491                     0             0.7298883 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.3915548                     0             0.0000000 #> GZMB                 0.0000000                     0             0.0000000 #> TSC2                 0.0000000                     0             0.0000000 #>          X52_Y-102..Fibroblast X51_Y-102..Fibroblast X50_Y-102..Fibroblast #> PDK4                 0.3053455              0.000000             0.0000000 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  1.1921367              2.181673             2.2321665 #> GZMB                 0.0000000              0.000000             0.6212216 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X49_Y-103..Fibroblast X51_Y-101..Fibroblast X47_Y-98..Fibroblast #> PDK4                  0.000000              0.000000             0.000000 #> TNFRSF17              0.000000              0.000000             0.000000 #> ICAM3                 0.000000              0.000000             0.000000 #> FAP                   1.138969              1.059192             1.311478 #> GZMB                  0.000000              0.000000             0.000000 #> TSC2                  0.000000              0.000000             0.000000 #>          X46_Y-98..Fibroblast X43_Y-98..Fibroblast X44_Y-99..Fibroblast #> PDK4                        0            0.3513731             0.000000 #> TNFRSF17                    0            0.0000000             0.000000 #> ICAM3                       0            0.0000000             0.000000 #> FAP                         0            0.4144908             0.463196 #> GZMB                        0            0.0000000             0.000000 #> TSC2                        0            0.0000000             0.000000 #>          X43_Y-99..Fibroblast X48_Y-99..Fibroblast X45_Y-99..Fibroblast #> PDK4                  0.00000                    0              0.00000 #> TNFRSF17              0.00000                    0              0.00000 #> ICAM3                 0.00000                    0              0.00000 #> FAP                   1.18004                    0              1.91316 #> GZMB                  0.00000                    0              0.00000 #> TSC2                  0.00000                    0              0.00000 #>          X43_Y-100..Fibroblast X45_Y-100..Fibroblast X44_Y-100..Fibroblast #> PDK4                 0.5248090             1.7239980             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.5677686             0.6377201             1.0420560 #> GZMB                 0.0000000             0.4549322             0.9203157 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X46_Y-100..Fibroblast X47_Y-100..Fibroblast X43_Y-101..Fibroblast #> PDK4                  0.514238             0.3856785             0.8207637 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   1.543306             1.1391150             0.9647810 #> GZMB                  0.000000             0.0000000             0.0000000 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X45_Y-101..Fibroblast X42_Y-101..Fibroblast X47_Y-101..Fibroblast #> PDK4                 0.6355150             0.4274901             0.5897791 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.7002347             0.5033148             0.6593061 #> GZMB                 0.5459186             0.0000000             0.4195564 #> TSC2                 0.0000000             0.0000000             0.3144089 #>          X44_Y-102..Fibroblast X43_Y-102..Fibroblast X47_Y-103..Fibroblast #> PDK4                  1.594328              0.000000             0.0000000 #> TNFRSF17              0.000000              0.000000             0.0000000 #> ICAM3                 0.000000              0.000000             0.0000000 #> FAP                   0.000000              1.637539             0.7632981 #> GZMB                  0.000000              0.000000             0.0000000 #> TSC2                  1.594328              0.000000             0.0000000 #>          X46_Y-101..Fibroblast X43_Y-103..Fibroblast X26_Y-92..Macrophage #> PDK4                  0.000000                     0             2.189387 #> TNFRSF17              0.000000                     0             0.000000 #> ICAM3                 0.000000                     0             0.000000 #> FAP                   1.167058                     0             0.000000 #> GZMB                  1.538374                     0             0.000000 #> TSC2                  0.000000                     0             0.000000 #>          X23_Y-92..Macrophage X28_Y-93..Macrophage X27_Y-93..Macrophage #> PDK4                        0             4.199363             2.799575 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             0.000000             0.000000 #> GZMB                        0             0.000000             0.000000 #> TSC2                        0             0.000000             0.000000 #>          X29_Y-94..Macrophage X25_Y-95..Macrophage X28_Y-95..Macrophage #> PDK4                        0             4.618426                    0 #> TNFRSF17                    0             0.000000                    0 #> ICAM3                       0             0.000000                    0 #> FAP                         0             0.000000                    0 #> GZMB                        0             0.000000                    0 #> TSC2                        0             0.000000                    0 #>          X27_Y-96..Macrophage X25_Y-96..Macrophage X26_Y-96..Macrophage #> PDK4                  0.00000            1.4664245             1.759709 #> TNFRSF17              0.00000            0.0000000             0.000000 #> ICAM3                 0.00000            0.0000000             0.000000 #> FAP                   0.00000            0.0000000             0.000000 #> GZMB                  1.15885            0.6325001             0.000000 #> TSC2                  0.00000            0.0000000             0.000000 #>          X24_Y-96..Macrophage X24_Y-97..Macrophage X26_Y-97..Macrophage #> PDK4                        0            1.4239816                    0 #> TNFRSF17                    0            0.0000000                    0 #> ICAM3                       0            0.0000000                    0 #> FAP                         0            0.0000000                    0 #> GZMB                        0            0.4792546                    0 #> TSC2                        0            0.4482441                    0 #>          X28_Y-94..Macrophage X24_Y-95..Macrophage X27_Y-95..Macrophage #> PDK4                 4.451387                    0              0.00000 #> TNFRSF17             0.000000                    0              0.00000 #> ICAM3                0.000000                    0              0.00000 #> FAP                  0.000000                    0              0.00000 #> GZMB                 0.000000                    0              1.15885 #> TSC2                 0.000000                    0              0.00000 #>          X62_Y-91..Macrophage X61_Y-91..Macrophage X64_Y-91..Macrophage #> PDK4                0.4836282            1.4258694             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.0000000            0.0000000             0.000000 #> GZMB                0.0000000            1.4562579             1.562333 #> TSC2                0.0000000            0.3565495             0.000000 #>          X63_Y-92..Macrophage X62_Y-92..Macrophage X61_Y-92..Macrophage #> PDK4                0.5502978            0.6607245            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            0.0000000            0.0000000 #> GZMB                0.0000000            0.0000000            0.6520674 #> TSC2                0.5574748            0.0000000            0.4584208 #>          X65_Y-92..Macrophage X64_Y-92..Macrophage X63_Y-93..Macrophage #> PDK4                        0                    0            1.1941480 #> TNFRSF17                    0                    0            0.0000000 #> ICAM3                       0                    0            0.0000000 #> FAP                         0                    0            0.0000000 #> GZMB                        0                    0            0.0000000 #> TSC2                        0                    0            0.6371141 #>          X64_Y-93..Macrophage X64_Y-94..Macrophage X61_Y-95..Macrophage #> PDK4                 1.166386             2.104024                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  0.000000             0.000000                    0 #> GZMB                 0.000000             0.000000                    0 #> TSC2                 0.000000             0.000000                    0 #>          X63_Y-95..Macrophage X64_Y-95..Macrophage X63_Y-96..Macrophage #> PDK4                 0.000000                    0                    0 #> TNFRSF17             0.000000                    0                    0 #> ICAM3                0.000000                    0                    0 #> FAP                  0.000000                    0                    0 #> GZMB                 2.170326                    0                    0 #> TSC2                 0.000000                    0                    0 #>          X60_Y-91..Macrophage X60_Y-92..Macrophage X61_Y-93..Macrophage #> PDK4                0.6711014             2.147261                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 0.0000000             0.000000                    0 #> GZMB                0.0000000             0.000000                    0 #> TSC2                0.0000000             0.000000                    0 #>          X62_Y-93..Macrophage X62_Y-94..Macrophage X62_Y-96..Macrophage #> PDK4                 0.000000             0.000000                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  0.000000             0.000000                    0 #> GZMB                 1.925955             0.000000                    0 #> TSC2                 2.213289             4.426577                    0 #>          X59_Y-91..Macrophage X57_Y-91..Macrophage X58_Y-91..Macrophage #> PDK4                0.9690034            0.0000000            1.1097872 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            0.0000000            0.0000000 #> GZMB                0.0000000            0.9774357            0.6981683 #> TSC2                0.0000000            0.9774357            0.6981683 #>          X57_Y-92..Macrophage X56_Y-92..Macrophage X58_Y-92..Macrophage #> PDK4                        0                    0            1.0697713 #> TNFRSF17                    0                    0            0.0000000 #> ICAM3                       0                    0            0.0000000 #> FAP                         0                    0            0.0000000 #> GZMB                        0                    0            0.8999245 #> TSC2                        0                    0            0.0000000 #>          X57_Y-93..Macrophage X59_Y-93..Macrophage X58_Y-93..Macrophage #> PDK4                        0            1.0406607            1.3875476 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.0000000            0.0000000 #> GZMB                        0            0.4499623            0.5999497 #> TSC2                        0            0.0000000            0.0000000 #>          X56_Y-93..Macrophage X54_Y-93..Macrophage X60_Y-93..Macrophage #> PDK4                 2.613055                    0                    0 #> TNFRSF17             0.000000                    0                    0 #> ICAM3                0.000000                    0                    0 #> FAP                  0.000000                    0                    0 #> GZMB                 0.000000                    0                    0 #> TSC2                 0.000000                    0                    0 #>          X59_Y-94..Macrophage X55_Y-94..Macrophage X57_Y-94..Macrophage #> PDK4                        0            1.2282688                    0 #> TNFRSF17                    0            0.0000000                    0 #> ICAM3                       0            0.0000000                    0 #> FAP                         0            0.0000000                    0 #> GZMB                        0            0.9188883                    0 #> TSC2                        0            0.0000000                    0 #>          X58_Y-94..Macrophage X55_Y-95..Macrophage X56_Y-95..Macrophage #> PDK4                 1.348733             1.245761            0.8488632 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  0.000000             0.000000            0.0000000 #> GZMB                 0.000000             0.000000            0.4019073 #> TSC2                 0.000000             0.000000            0.0000000 #>          X57_Y-95..Macrophage X58_Y-95..Macrophage X59_Y-95..Macrophage #> PDK4                0.8607933                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 0.0000000                    0                    0 #> GZMB                0.0000000                    0                    0 #> TSC2                0.0000000                    0                    0 #>          X56_Y-96..Macrophage X60_Y-96..Macrophage X57_Y-96..Macrophage #> PDK4                0.0000000            0.0000000            0.9596537 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            0.0000000            0.0000000 #> GZMB                0.0000000            0.9323278            0.4720003 #> TSC2                0.4413181            0.0000000            0.0000000 #>          X58_Y-97..Macrophage X56_Y-97..Macrophage X57_Y-97..Macrophage #> PDK4                        0                    0            0.0000000 #> TNFRSF17                    0                    0            0.0000000 #> ICAM3                       0                    0            0.0000000 #> FAP                         0                    0            0.0000000 #> GZMB                        0                    0            0.0000000 #> TSC2                        0                    0            0.3939276 #>          X55_Y-97..Macrophage X57_Y-98..Macrophage X56_Y-98..Macrophage #> PDK4                0.0000000            0.4495778            0.7040486 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            0.0000000            0.0000000 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.7536366            0.4814671            0.0000000 #>          X55_Y-91..Macrophage X59_Y-92..Macrophage X61_Y-96..Macrophage #> PDK4                0.0000000            1.0697713                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.0000000            0.0000000                    0 #> GZMB                0.7607077            0.8999245                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X60_Y-97..Macrophage X59_Y-97..Macrophage X75_Y-97..Macrophage #> PDK4                 1.189682              3.82734                    0 #> TNFRSF17             0.000000              0.00000                    0 #> ICAM3                0.000000              0.00000                    0 #> FAP                  0.000000              0.00000                    0 #> GZMB                 0.000000              0.00000                    0 #> TSC2                 0.000000              0.00000                    0 #>          X73_Y-97..Macrophage X78_Y-98..Macrophage X78_Y-99..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X77_Y-99..Macrophage X76_Y-100..Macrophage X74_Y-100..Macrophage #> PDK4                 0.000000              0.000000               4.71949 #> TNFRSF17             0.000000              0.000000               0.00000 #> ICAM3                0.000000              0.000000               0.00000 #> FAP                  0.000000              0.000000               0.00000 #> GZMB                 0.000000              0.000000               0.00000 #> TSC2                 1.396223              2.094335               0.00000 #>          X73_Y-101..Macrophage X78_Y-101..Macrophage X79_Y-102..Macrophage #> PDK4                  0.000000                     0                     0 #> TNFRSF17              0.000000                     0                     0 #> ICAM3                 0.000000                     0                     0 #> FAP                   0.000000                     0                     0 #> GZMB                  4.874205                     0                     0 #> TSC2                  0.000000                     0                     0 #>          X74_Y-102..Macrophage X78_Y-102..Macrophage X76_Y-104..Macrophage #> PDK4                         0                     0                     0 #> TNFRSF17                     0                     0                     0 #> ICAM3                        0                     0                     0 #> FAP                          0                     0                     0 #> GZMB                         0                     0                     0 #> TSC2                         0                     0                     0 #>          X77_Y-98..Macrophage X76_Y-98..Macrophage X74_Y-99..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X77_Y-104..Macrophage X78_Y-85..Macrophage X73_Y-87..Macrophage #> PDK4                         0                    0                    0 #> TNFRSF17                     0                    0                    0 #> ICAM3                        0                    0                    0 #> FAP                          0                    0                    0 #> GZMB                         0                    0                    0 #> TSC2                         0                    0                    0 #>          X76_Y-87..Macrophage X75_Y-87..Macrophage X76_Y-88..Macrophage #> PDK4                        0                    0             4.282601 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X74_Y-88..Macrophage X79_Y-88..Macrophage X77_Y-89..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X75_Y-90..Macrophage X78_Y-90..Macrophage X76_Y-90..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X77_Y-86..Macrophage X77_Y-87..Macrophage X75_Y-89..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X73_Y-89..Macrophage X77_Y-90..Macrophage X73_Y-91..Macrophage #> PDK4                        0             5.138686                    0 #> TNFRSF17                    0             0.000000                    0 #> ICAM3                       0             0.000000                    0 #> FAP                         0             0.000000                    0 #> GZMB                        0             0.000000                    0 #> TSC2                        0             0.000000                    0 #>          X29_Y-74..Macrophage X30_Y-74..Macrophage X32_Y-75..Macrophage #> PDK4                        0                    0             1.874679 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             1.874679 #>          X35_Y-76..Macrophage X31_Y-76..Macrophage X35_Y-78..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X32_Y-79..Macrophage X30_Y-73..Macrophage X31_Y-73..Macrophage #> PDK4                 2.368074                    0             0.000000 #> TNFRSF17             0.000000                    0             0.000000 #> ICAM3                0.000000                    0             0.000000 #> FAP                  0.000000                    0             0.000000 #> GZMB                 0.000000                    0             0.000000 #> TSC2                 0.000000                    0             4.241228 #>          X31_Y-74..Macrophage X31_Y-75..Macrophage X34_Y-78..Macrophage #> PDK4                 1.012934             1.012934                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  0.000000             0.000000                    0 #> GZMB                 0.000000             0.000000                    0 #> TSC2                 1.060307             0.000000                    0 #>          X32_Y-78..Macrophage X37_Y-68..Macrophage X39_Y-68..Macrophage #> PDK4                 2.368074             4.085632             1.852899 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  0.000000             0.000000             0.000000 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             0.000000 #>          X42_Y-68..Macrophage X42_Y-69..Macrophage X39_Y-69..Macrophage #> PDK4                        0                    0             2.197225 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X41_Y-69..Macrophage X40_Y-70..Macrophage X39_Y-70..Macrophage #> PDK4                        0             2.626083             4.462141 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             0.000000             0.000000 #> GZMB                        0             0.000000             0.000000 #> TSC2                        0             0.000000             0.000000 #>          X37_Y-70..Macrophage X36_Y-71..Macrophage X40_Y-71..Macrophage #> PDK4                 3.417678             4.406634            1.5574634 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  0.000000             0.000000            0.0000000 #> GZMB                 0.000000             0.000000            0.5553808 #> TSC2                 0.000000             0.000000            0.0000000 #>          X38_Y-71..Macrophage X39_Y-71..Macrophage X40_Y-72..Macrophage #> PDK4                        0                    0             1.318963 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X38_Y-72..Macrophage X41_Y-72..Macrophage X39_Y-73..Macrophage #> PDK4                        0             2.586486             1.384641 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             0.000000             0.000000 #> GZMB                        0             0.000000             0.000000 #> TSC2                        0             0.000000             0.000000 #>          X36_Y-69..Macrophage X38_Y-69..Macrophage X40_Y-73..Macrophage #> PDK4                 2.127412                    0            0.6953102 #> TNFRSF17             0.000000                    0            0.0000000 #> ICAM3                0.000000                    0            0.0000000 #> FAP                  0.000000                    0            0.0000000 #> GZMB                 0.000000                    0            0.0000000 #> TSC2                 0.000000                    0            0.0000000 #>          X42_Y-73..Macrophage X39_Y-74..Macrophage X38_Y-74..Macrophage #> PDK4                 3.485709             1.723327             2.387494 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  0.000000             0.000000             0.000000 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             0.000000 #>          X36_Y-75..Macrophage X38_Y-75..Macrophage X40_Y-75..Macrophage #> PDK4                        0             4.125416                    0 #> TNFRSF17                    0             0.000000                    0 #> ICAM3                       0             0.000000                    0 #> FAP                         0             0.000000                    0 #> GZMB                        0             0.000000                    0 #> TSC2                        0             0.000000                    0 #>          X37_Y-75..Macrophage X41_Y-76..Macrophage X38_Y-76..Macrophage #> PDK4                 3.155804             4.887178                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  0.000000             0.000000                    0 #> GZMB                 0.000000             0.000000                    0 #> TSC2                 0.000000             0.000000                    0 #>          X42_Y-77..Macrophage X36_Y-78..Macrophage X40_Y-78..Macrophage #> PDK4                  3.16435                    0                    0 #> TNFRSF17              0.00000                    0                    0 #> ICAM3                 0.00000                    0                    0 #> FAP                   0.00000                    0                    0 #> GZMB                  0.00000                    0                    0 #> TSC2                  0.00000                    0                    0 #>          X41_Y-78..Macrophage X38_Y-78..Macrophage X37_Y-78..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X42_Y-78..Macrophage X37_Y-79..Macrophage X38_Y-73..Macrophage #> PDK4                        0                    0             1.425194 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X78_Y-72..Macrophage X78_Y-73..Macrophage X77_Y-73..Macrophage #> PDK4                        0             1.918412            0.6106911 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             0.000000            0.0000000 #> GZMB                        0             0.000000            0.5462550 #> TSC2                        0             0.000000            0.0000000 #>          X73_Y-73..Macrophage X79_Y-73..Macrophage X76_Y-74..Macrophage #> PDK4                 1.432864             1.098291             0.000000 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  0.000000             0.000000             0.000000 #> GZMB                 0.000000             0.000000             1.449386 #> TSC2                 0.000000             0.000000             0.000000 #>          X73_Y-74..Macrophage X78_Y-74..Macrophage X77_Y-74..Macrophage #> PDK4                 1.704949             1.315548            0.5234495 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  0.000000             0.000000            0.0000000 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X74_Y-74..Macrophage X73_Y-75..Macrophage X76_Y-75..Macrophage #> PDK4                        0             1.459591            0.7616073 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             0.000000            0.0000000 #> GZMB                        0             0.000000            0.0000000 #> TSC2                        0             0.000000            0.0000000 #>          X77_Y-75..Macrophage X75_Y-75..Macrophage X76_Y-76..Macrophage #> PDK4                        0             1.434655             1.195528 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             0.000000             0.000000 #> GZMB                        0             0.000000             0.000000 #> TSC2                        0             0.000000             0.000000 #>          X77_Y-76..Macrophage X78_Y-76..Macrophage X77_Y-77..Macrophage #> PDK4                0.6276173                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 0.0000000                    0                    0 #> GZMB                0.0000000                    0                    0 #> TSC2                0.0000000                    0                    0 #>          X76_Y-77..Macrophage X74_Y-77..Macrophage X78_Y-77..Macrophage #> PDK4                 1.615775             4.485477            0.0000000 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  0.000000             0.000000            0.0000000 #> GZMB                 0.000000             4.485477            0.0000000 #> TSC2                 0.000000             0.000000            0.4610182 #>          X78_Y-78..Macrophage X76_Y-78..Macrophage X75_Y-78..Macrophage #> PDK4                        0              1.02624            0.8666407 #> TNFRSF17                    0              0.00000            0.0000000 #> ICAM3                       0              0.00000            0.0000000 #> FAP                         0              0.00000            0.0000000 #> GZMB                        0              0.00000            0.0000000 #> TSC2                        0              0.00000            0.0000000 #>          X74_Y-78..Macrophage X77_Y-79..Macrophage X75_Y-79..Macrophage #> PDK4                 4.275582                    0             1.083301 #> TNFRSF17             0.000000                    0             0.000000 #> ICAM3                0.000000                    0             0.000000 #> FAP                  0.000000                    0             0.000000 #> GZMB                 0.000000                    0             1.081453 #> TSC2                 0.000000                    0             0.000000 #>          X73_Y-72..Macrophage X74_Y-73..Macrophage X78_Y-75..Macrophage #> PDK4                1.0733668             1.141706                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 0.0000000             0.000000                    0 #> GZMB                0.0000000             0.000000                    0 #> TSC2                0.3959747             0.000000                    0 #>          X78_Y-79..Macrophage X64_Y-67..Macrophage X66_Y-68..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X62_Y-69..Macrophage X62_Y-70..Macrophage X64_Y-72..Macrophage #> PDK4                 3.539359                    0                    0 #> TNFRSF17             0.000000                    0                    0 #> ICAM3                0.000000                    0                    0 #> FAP                  0.000000                    0                    0 #> GZMB                 0.000000                    0                    0 #> TSC2                 0.000000                    0                    0 #>          X65_Y-73..Macrophage X66_Y-73..Macrophage X62_Y-68..Macrophage #> PDK4                        0             0.000000             1.769679 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             0.000000             0.000000 #> GZMB                        0             1.422871             0.000000 #> TSC2                        0             0.000000             0.000000 #>          X63_Y-70..Macrophage X65_Y-71..Macrophage X63_Y-71..Macrophage #> PDK4                        0             4.138814                    0 #> TNFRSF17                    0             0.000000                    0 #> ICAM3                       0             0.000000                    0 #> FAP                         0             0.000000                    0 #> GZMB                        0             0.000000                    0 #> TSC2                        0             0.000000                    0 #>          X64_Y-71..Macrophage X65_Y-72..Macrophage X66_Y-72..Macrophage #> PDK4                        0                    0             0.000000 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             1.067153 #> TSC2                        0                    0             0.000000 #>          X63_Y-73..Macrophage X64_Y-74..Macrophage X65_Y-74..Macrophage #> PDK4                0.0000000            1.1694664                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.0000000            0.0000000                    0 #> GZMB                0.7482577            0.6113098                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X65_Y-75..Macrophage X66_Y-75..Macrophage X67_Y-75..Macrophage #> PDK4                0.7185323                    0            0.9210538 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.0000000                    0            0.0000000 #> GZMB                0.0000000                    0            0.0000000 #> TSC2                0.0000000                    0            0.0000000 #>          X61_Y-75..Macrophage X62_Y-76..Macrophage X65_Y-76..Macrophage #> PDK4                        0                    0            0.8622388 #> TNFRSF17                    0                    0            0.0000000 #> ICAM3                       0                    0            0.0000000 #> FAP                         0                    0            0.0000000 #> GZMB                        0                    0            0.0000000 #> TSC2                        0                    0            0.0000000 #>          X66_Y-77..Macrophage X61_Y-78..Macrophage X63_Y-74..Macrophage #> PDK4                 1.232696             3.795001            0.4784200 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  0.000000             0.000000            0.0000000 #> GZMB                 0.000000             0.000000            0.5344698 #> TSC2                 0.000000             0.000000            0.0000000 #>          X67_Y-77..Macrophage X72_Y-72..Macrophage X72_Y-73..Macrophage #> PDK4                        0            1.0272769            0.6326516 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.0000000            0.0000000 #> GZMB                        0            0.6158943            0.0000000 #> TSC2                        0            0.0000000            0.0000000 #>          X68_Y-73..Macrophage X67_Y-73..Macrophage X68_Y-74..Macrophage #> PDK4                0.4134899            1.1520496            0.3649441 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            0.0000000            0.0000000 #> GZMB                0.0000000            0.0000000            0.0000000 #> TSC2                0.0000000            0.5318148            0.0000000 #>          X72_Y-74..Macrophage X67_Y-74..Macrophage X69_Y-74..Macrophage #> PDK4                0.0000000            0.6700773            2.1043088 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            0.0000000            0.0000000 #> GZMB                0.0000000            0.0000000            0.8806003 #> TSC2                0.7432998            0.0000000            0.0000000 #>          X69_Y-75..Macrophage X72_Y-75..Macrophage X71_Y-75..Macrophage #> PDK4                1.8036933             1.459591            0.0000000 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.0000000             0.000000            0.0000000 #> GZMB                0.7548003             0.000000            0.0000000 #> TSC2                0.0000000             1.486600            0.8919597 #>          X70_Y-75..Macrophage X67_Y-76..Macrophage X70_Y-76..Macrophage #> PDK4                0.7046366            0.6022974            0.5745936 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            0.0000000            0.0000000 #> GZMB                0.0000000            0.0000000            0.2617247 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X68_Y-76..Macrophage X71_Y-76..Macrophage X69_Y-76..Macrophage #> PDK4                 1.332164            0.8048759             1.836656 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  0.000000            0.0000000             0.000000 #> GZMB                 0.000000            0.3664146             0.000000 #> TSC2                 0.000000            0.3162282             0.000000 #>          X66_Y-76..Macrophage X68_Y-77..Macrophage X70_Y-77..Macrophage #> PDK4                 1.849044            1.1840513                    0 #> TNFRSF17             0.000000            0.0000000                    0 #> ICAM3                0.000000            0.0000000                    0 #> FAP                  0.000000            0.0000000                    0 #> GZMB                 0.000000            0.2638755                    0 #> TSC2                 0.000000            0.0000000                    0 #>          X69_Y-77..Macrophage X70_Y-78..Macrophage X71_Y-78..Macrophage #> PDK4                 1.435565            0.9544703            1.9263941 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.000000            0.0000000            0.0000000 #> GZMB                 0.000000            0.4445749            0.5927665 #> TSC2                 0.000000            0.2230654            0.0000000 #>          X72_Y-78..Macrophage X70_Y-79..Macrophage X71_Y-79..Macrophage #> PDK4                 1.096645            1.3222012            1.7215451 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.000000            0.0000000            0.0000000 #> GZMB                 0.000000            0.5379443            0.5763689 #> TSC2                 0.000000            0.2841130            0.3044067 #>          X68_Y-75..Macrophage X72_Y-76..Macrophage X73_Y-78..Macrophage #> PDK4                  2.21088                    0                    0 #> TNFRSF17              0.00000                    0                    0 #> ICAM3                 0.00000                    0                    0 #> FAP                   0.00000                    0                    0 #> GZMB                  1.32090                    0                    0 #> TSC2                  0.00000                    0                    0 #>          X69_Y-78..Macrophage X57_Y-73..Macrophage X55_Y-75..Macrophage #> PDK4                 0.465669                    0             1.909333 #> TNFRSF17             0.000000                    0             0.000000 #> ICAM3                0.000000                    0             0.000000 #> FAP                  0.000000                    0             0.000000 #> GZMB                 0.000000                    0             0.000000 #> TSC2                 0.000000                    0             0.000000 #>          X54_Y-76..Macrophage X58_Y-76..Macrophage X54_Y-77..Macrophage #> PDK4                0.6698315             1.756865            0.0000000 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.0000000             0.000000            0.0000000 #> GZMB                0.6628311             0.000000            0.7953974 #> TSC2                0.0000000             0.000000            0.8390173 #>          X55_Y-77..Macrophage X60_Y-78..Macrophage X59_Y-78..Macrophage #> PDK4                0.0000000             1.355521                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 0.0000000             0.000000                    0 #> GZMB                0.7923393             0.000000                    0 #> TSC2                0.0000000             0.000000                    0 #>          X55_Y-78..Macrophage X56_Y-79..Macrophage X59_Y-75..Macrophage #> PDK4                0.0000000                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 0.0000000                    0                    0 #> GZMB                0.6602827                    0                    0 #> TSC2                0.0000000                    0                    0 #>          X58_Y-75..Macrophage X73_Y-66..Macrophage X72_Y-67..Macrophage #> PDK4                 1.171244             1.085297            1.2456563 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  0.000000             0.000000            0.0000000 #> GZMB                 0.000000             0.000000            0.2373406 #> TSC2                 0.000000             0.000000            0.0000000 #>          X73_Y-67..Macrophage X68_Y-67..Macrophage X71_Y-67..Macrophage #> PDK4                0.6931254                    0             0.000000 #> TNFRSF17            0.0000000                    0             0.000000 #> ICAM3               0.0000000                    0             0.000000 #> FAP                 0.0000000                    0             0.000000 #> GZMB                0.2804934                    0             0.000000 #> TSC2                0.0000000                    0             3.761591 #>          X72_Y-68..Macrophage X73_Y-68..Macrophage X68_Y-68..Macrophage #> PDK4                 0.000000            0.5779682             1.826548 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  0.000000            0.0000000             0.000000 #> GZMB                 0.507425            0.2854266             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X72_Y-69..Macrophage X69_Y-69..Macrophage X72_Y-70..Macrophage #> PDK4                0.3950819             1.217699            0.6486264 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.0000000             0.000000            0.0000000 #> GZMB                0.4230929             0.000000            0.3461670 #> TSC2                0.0000000             0.000000            0.0000000 #>          X71_Y-70..Macrophage X73_Y-70..Macrophage X70_Y-70..Macrophage #> PDK4                0.7111473            0.8947885                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.0000000            0.0000000                    0 #> GZMB                0.0000000            0.0000000                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X72_Y-71..Macrophage X67_Y-71..Macrophage X73_Y-71..Macrophage #> PDK4                0.9131350            0.8914254            0.7669377 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            0.0000000            0.0000000 #> GZMB                0.5474616            0.0000000            0.4479231 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X68_Y-72..Macrophage X67_Y-72..Macrophage X69_Y-68..Macrophage #> PDK4                0.0000000            0.0000000             3.653096 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.0000000            0.0000000             0.000000 #> GZMB                0.0000000            0.0000000             0.000000 #> TSC2                0.8676237            0.5784158             0.000000 #>          X68_Y-70..Macrophage X54_Y-72..Macrophage X48_Y-73..Macrophage #> PDK4                 4.068535                    0             1.008806 #> TNFRSF17             0.000000                    0             0.000000 #> ICAM3                0.000000                    0             0.000000 #> FAP                  0.000000                    0             0.000000 #> GZMB                 0.000000                    0             0.000000 #> TSC2                 0.000000                    0             0.000000 #>          X53_Y-73..Macrophage X52_Y-73..Macrophage X49_Y-73..Macrophage #> PDK4                 1.396665            1.2392282                    0 #> TNFRSF17             0.000000            0.0000000                    0 #> ICAM3                0.000000            0.0000000                    0 #> FAP                  0.000000            0.0000000                    0 #> GZMB                 0.000000            0.5701401                    0 #> TSC2                 0.000000            0.2304150                    0 #>          X51_Y-73..Macrophage X52_Y-74..Macrophage X50_Y-74..Macrophage #> PDK4                0.9679283            1.3440690             1.545712 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.0000000            0.0000000             0.000000 #> GZMB                1.1111064            0.2330604             0.000000 #> TSC2                0.4608299            0.2048133             0.000000 #>          X51_Y-74..Macrophage X53_Y-74..Macrophage X53_Y-75..Macrophage #> PDK4                 0.000000            0.7777989                    0 #> TNFRSF17             0.000000            0.0000000                    0 #> ICAM3                0.000000            0.0000000                    0 #> FAP                  0.000000            0.0000000                    0 #> GZMB                 1.320565            0.4195087                    0 #> TSC2                 0.000000            0.0000000                    0 #>          X54_Y-75..Macrophage X53_Y-76..Macrophage X49_Y-78..Macrophage #> PDK4                        0             1.004747            0.5056399 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             0.000000            0.0000000 #> GZMB                        0             0.000000            0.5383177 #> TSC2                        0             0.000000            0.0000000 #>          X54_Y-78..Macrophage X48_Y-78..Macrophage X52_Y-78..Macrophage #> PDK4                        0             1.236653            0.3920641 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             0.000000            0.0000000 #> GZMB                        0             0.271245            0.0000000 #> TSC2                        0             0.000000            0.0000000 #>          X53_Y-78..Macrophage X50_Y-78..Macrophage X54_Y-79..Macrophage #> PDK4                1.2393341            0.3630847            0.8548446 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            0.0000000            0.0000000 #> GZMB                0.8888926            0.3630847            0.0000000 #> TSC2                0.2915969            0.0000000            0.0000000 #>          X50_Y-79..Macrophage X51_Y-79..Macrophage X48_Y-79..Macrophage #> PDK4                0.0000000            0.0000000                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.0000000            0.0000000                    0 #> GZMB                0.6044792            0.6554841                    0 #> TSC2                0.0000000            0.2071939                    0 #>          X52_Y-79..Macrophage X49_Y-79..Macrophage X52_Y-72..Macrophage #> PDK4                0.3899701            0.7356189            0.9787459 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            0.0000000            0.0000000 #> GZMB                0.0000000            0.0000000            1.5664696 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X48_Y-77..Macrophage X51_Y-78..Macrophage X53_Y-79..Macrophage #> PDK4                 1.551083                    0            0.4815653 #> TNFRSF17             0.000000                    0            0.0000000 #> ICAM3                0.000000                    0            0.0000000 #> FAP                  0.000000                    0            0.0000000 #> GZMB                 0.000000                    0            0.4850353 #> TSC2                 0.000000                    0            0.0000000 #>          X43_Y-91..Macrophage X47_Y-91..Macrophage X42_Y-91..Macrophage #> PDK4                 1.928342             0.755739            0.5904352 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  0.000000             0.000000            0.0000000 #> GZMB                 0.000000             0.000000            1.3338738 #> TSC2                 0.000000             0.000000            0.0000000 #>          X44_Y-91..Macrophage X48_Y-92..Macrophage X47_Y-92..Macrophage #> PDK4                 1.928342            0.0000000            2.3154210 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.000000            0.0000000            0.0000000 #> GZMB                 0.000000            0.0000000            0.5305103 #> TSC2                 0.000000            0.2422594            0.0000000 #>          X46_Y-92..Macrophage X44_Y-93..Macrophage X46_Y-93..Macrophage #> PDK4                2.2636091                    0              1.41815 #> TNFRSF17            0.0000000                    0              0.00000 #> ICAM3               0.0000000                    0              0.00000 #> FAP                 0.0000000                    0              0.00000 #> GZMB                0.7427144                    0              0.00000 #> TSC2                0.0000000                    0              0.00000 #>          X44_Y-94..Macrophage X46_Y-94..Macrophage X48_Y-94..Macrophage #> PDK4                        0              1.44708                    0 #> TNFRSF17                    0              0.00000                    0 #> ICAM3                       0              0.00000                    0 #> FAP                         0              0.00000                    0 #> GZMB                        0              0.00000                    0 #> TSC2                        0              0.00000                    0 #>          X45_Y-94..Macrophage X44_Y-95..Macrophage X46_Y-95..Macrophage #> PDK4                        0                    0             2.636142 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X46_Y-96..Macrophage X45_Y-96..Macrophage X47_Y-96..Macrophage #> PDK4                        0                    0            0.7913306 #> TNFRSF17                    0                    0            0.0000000 #> ICAM3                       0                    0            0.0000000 #> FAP                         0                    0            0.0000000 #> GZMB                        0                    0            0.0000000 #> TSC2                        0                    0            0.0000000 #>          X46_Y-97..Macrophage X44_Y-97..Macrophage X44_Y-98..Macrophage #> PDK4                        0                    0             1.852497 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X48_Y-91..Macrophage X44_Y-92..Macrophage X47_Y-94..Macrophage #> PDK4                0.4890076                    0             1.964683 #> TNFRSF17            0.0000000                    0             0.000000 #> ICAM3               0.0000000                    0             0.000000 #> FAP                 0.0000000                    0             0.000000 #> GZMB                0.0000000                    0             0.000000 #> TSC2                0.1852572                    0             0.000000 #>          X48_Y-95..Macrophage X45_Y-95..Macrophage X47_Y-97..Macrophage #> PDK4                  1.22888                    0            0.9596186 #> TNFRSF17              0.00000                    0            0.0000000 #> ICAM3                 0.00000                    0            0.0000000 #> FAP                   0.00000                    0            0.0000000 #> GZMB                  0.00000                    0            0.0000000 #> TSC2                  0.00000                    0            0.0000000 #>          X48_Y-97..Macrophage X22_Y-74..Macrophage X23_Y-77..Macrophage #> PDK4                 1.919237                    0                    0 #> TNFRSF17             0.000000                    0                    0 #> ICAM3                0.000000                    0                    0 #> FAP                  0.000000                    0                    0 #> GZMB                 0.000000                    0                    0 #> TSC2                 0.000000                    0                    0 #>          X22_Y-78..Macrophage X23_Y-79..Macrophage X22_Y-79..Macrophage #> PDK4                 2.451139             1.293121                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  0.000000             0.000000                    0 #> GZMB                 0.000000             0.000000                    0 #> TSC2                 0.000000             0.000000                    0 #>          X24_Y-77..Macrophage X24_Y-73..Macrophage X26_Y-73..Macrophage #> PDK4                 2.217389             1.404865                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  0.000000             0.000000                    0 #> GZMB                 0.000000             0.000000                    0 #> TSC2                 0.000000             0.000000                    0 #>          X26_Y-74..Macrophage X28_Y-74..Macrophage X27_Y-75..Macrophage #> PDK4                 1.117198                    0                    0 #> TNFRSF17             0.000000                    0                    0 #> ICAM3                0.000000                    0                    0 #> FAP                  0.000000                    0                    0 #> GZMB                 0.000000                    0                    0 #> TSC2                 0.000000                    0                    0 #>          X26_Y-75..Macrophage X24_Y-76..Macrophage X25_Y-76..Macrophage #> PDK4                        0              2.11725             2.695471 #> TNFRSF17                    0              0.00000             0.000000 #> ICAM3                       0              0.00000             0.000000 #> FAP                         0              0.00000             0.000000 #> GZMB                        0              0.00000             0.000000 #> TSC2                        0              0.00000             0.000000 #>          X26_Y-78..Macrophage X25_Y-73..Macrophage X28_Y-76..Macrophage #> PDK4                        0                    0             3.679083 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X25_Y-77..Macrophage X27_Y-78..Macrophage X26_Y-79..Macrophage #> PDK4                 2.762229                    0                    0 #> TNFRSF17             0.000000                    0                    0 #> ICAM3                0.000000                    0                    0 #> FAP                  0.000000                    0                    0 #> GZMB                 0.000000                    0                    0 #> TSC2                 0.000000                    0                    0 #>          X31_Y-69..Macrophage X34_Y-71..Macrophage X30_Y-72..Macrophage #> PDK4                        0             2.914829             2.692035 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             0.000000             0.000000 #> GZMB                        0             0.000000             0.000000 #> TSC2                        0             0.000000             0.000000 #>          X33_Y-67..Macrophage X30_Y-68..Macrophage X33_Y-70..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X33_Y-71..Macrophage X35_Y-71..Macrophage X31_Y-72..Macrophage #> PDK4                 3.481555             2.418141                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  0.000000             0.000000                    0 #> GZMB                 0.000000             0.000000                    0 #> TSC2                 0.000000             0.000000                    0 #>          X32_Y-72..Macrophage X33_Y-72..Macrophage X33_Y-73..Macrophage #> PDK4                 0.000000              4.91864                    0 #> TNFRSF17             0.000000              0.00000                    0 #> ICAM3                0.000000              0.00000                    0 #> FAP                  0.000000              0.00000                    0 #> GZMB                 0.000000              0.00000                    0 #> TSC2                 2.365282              0.00000                    0 #>          X32_Y-65..Macrophage X30_Y-79..Macrophage X31_Y-79..Macrophage #> PDK4                        0             1.954271              1.45981 #> TNFRSF17                    0             0.000000              0.00000 #> ICAM3                       0             0.000000              0.00000 #> FAP                         0             0.000000              0.00000 #> GZMB                        0             0.000000              0.00000 #> TSC2                        0             0.000000              0.00000 #>          X34_Y-80..Macrophage X30_Y-80..Macrophage X31_Y-80..Macrophage #> PDK4                 0.000000                    0             1.958616 #> TNFRSF17             0.000000                    0             0.000000 #> ICAM3                0.000000                    0             0.000000 #> FAP                  0.000000                    0             0.000000 #> GZMB                 0.000000                    0             0.000000 #> TSC2                 2.100773                    0             0.000000 #>          X35_Y-81..Macrophage X35_Y-83..Macrophage X33_Y-83..Macrophage #> PDK4                 1.978327            0.5703606             4.416373 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  0.000000            0.0000000             0.000000 #> GZMB                 0.000000            0.5162352             0.000000 #> TSC2                 1.978327            0.0000000             0.000000 #>          X31_Y-83..Macrophage X34_Y-83..Macrophage X34_Y-84..Macrophage #> PDK4                 1.286991            2.2244917             2.295338 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  0.000000            0.0000000             0.000000 #> GZMB                 0.000000            0.0000000             0.000000 #> TSC2                 0.000000            0.6481151             0.000000 #>          X33_Y-84..Macrophage X30_Y-84..Macrophage X35_Y-84..Macrophage #> PDK4                 4.062903                    0            0.9981310 #> TNFRSF17             0.000000                    0            0.0000000 #> ICAM3                0.000000                    0            0.0000000 #> FAP                  0.000000                    0            0.0000000 #> GZMB                 0.000000                    0            0.9034115 #> TSC2                 0.000000                    0            0.0000000 #>          X33_Y-85..Macrophage X32_Y-80..Macrophage X35_Y-80..Macrophage #> PDK4                  3.08498                    0             0.000000 #> TNFRSF17              0.00000                    0             0.000000 #> ICAM3                 0.00000                    0             0.000000 #> FAP                   0.00000                    0             0.000000 #> GZMB                  0.00000                    0             0.000000 #> TSC2                  0.00000                    0             1.400515 #>          X33_Y-81..Macrophage X34_Y-82..Macrophage X40_Y-65..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X41_Y-65..Macrophage X41_Y-66..Macrophage X40_Y-66..Macrophage #> PDK4                        0              1.03319             2.066379 #> TNFRSF17                    0              0.00000             0.000000 #> ICAM3                       0              0.00000             0.000000 #> FAP                         0              0.00000             0.000000 #> GZMB                        0              0.00000             0.000000 #> TSC2                        0              0.00000             0.000000 #>          X22_Y-67..Macrophage X23_Y-69..Macrophage X23_Y-70..Macrophage #> PDK4                        0             1.539079                    0 #> TNFRSF17                    0             0.000000                    0 #> ICAM3                       0             0.000000                    0 #> FAP                         0             0.000000                    0 #> GZMB                        0             0.000000                    0 #> TSC2                        0             0.000000                    0 #>          X22_Y-69..Macrophage X27_Y-80..Macrophage X29_Y-80..Macrophage #> PDK4                        0             4.133923                    0 #> TNFRSF17                    0             0.000000                    0 #> ICAM3                       0             0.000000                    0 #> FAP                         0             0.000000                    0 #> GZMB                        0             0.000000                    0 #> TSC2                        0             0.000000                    0 #>          X25_Y-80..Macrophage X29_Y-81..Macrophage X26_Y-81..Macrophage #> PDK4                        0                    0             2.907347 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X26_Y-82..Macrophage X24_Y-79..Macrophage X28_Y-80..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X26_Y-80..Macrophage X23_Y-81..Macrophage X26_Y-66..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X25_Y-66..Macrophage X25_Y-67..Macrophage X27_Y-67..Macrophage #> PDK4                 1.009489             1.009489            0.8509649 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  0.000000             0.000000            0.0000000 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X24_Y-67..Macrophage X27_Y-68..Macrophage X26_Y-68..Macrophage #> PDK4                        0            0.3427122            0.6283057 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.0000000            0.0000000 #> GZMB                        0            0.0000000            0.0000000 #> TSC2                        0            0.0000000            0.0000000 #>          X27_Y-69..Macrophage X26_Y-69..Macrophage X25_Y-69..Macrophage #> PDK4                        0                    0             2.543437 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X29_Y-70..Macrophage X25_Y-71..Macrophage X28_Y-71..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X26_Y-72..Macrophage X25_Y-72..Macrophage X26_Y-67..Macrophage #> PDK4                        0             2.107297            0.8326417 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             0.000000            0.0000000 #> GZMB                        0             0.000000            0.0000000 #> TSC2                        0             0.000000            0.0000000 #>          X25_Y-68..Macrophage X29_Y-68..Macrophage X29_Y-71..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X28_Y-72..Macrophage X22_Y-80..Macrophage X24_Y-80..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X22_Y-83..Macrophage X45_Y-64..Macrophage X44_Y-65..Macrophage #> PDK4                        0                    0             1.214058 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X47_Y-65..Macrophage X48_Y-65..Macrophage X45_Y-65..Macrophage #> PDK4                0.8508801             1.657721            0.6157095 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.0000000             0.000000            0.0000000 #> GZMB                0.0000000             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.0000000 #>          X43_Y-65..Macrophage X44_Y-66..Macrophage X47_Y-66..Macrophage #> PDK4                 0.000000                    0             1.107853 #> TNFRSF17             0.000000                    0             0.000000 #> ICAM3                0.000000                    0             0.000000 #> FAP                  0.000000                    0             0.000000 #> GZMB                 0.000000                    0             0.000000 #> TSC2                 1.750587                    0             0.000000 #>          X43_Y-66..Macrophage X45_Y-66..Macrophage X48_Y-66..Macrophage #> PDK4                 0.000000             0.410473             1.657721 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  0.000000             0.000000             0.000000 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 1.750587             0.000000             0.000000 #>          X46_Y-67..Macrophage X44_Y-64..Macrophage X48_Y-64..Macrophage #> PDK4                0.9105434             1.214058                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 0.0000000             0.000000                    0 #> GZMB                0.0000000             0.000000                    0 #> TSC2                0.8080063             0.000000                    0 #>          X54_Y-64..Macrophage X54_Y-65..Macrophage X53_Y-65..Macrophage #> PDK4                 2.572119             2.630786             2.108227 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  0.000000             0.000000             0.000000 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             0.000000 #>          X49_Y-65..Macrophage X51_Y-65..Macrophage X52_Y-65..Macrophage #> PDK4                 4.455584            0.9672564             1.480414 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  0.000000            0.0000000             0.000000 #> GZMB                 3.773983            0.0000000             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X50_Y-65..Macrophage X53_Y-66..Macrophage X52_Y-66..Macrophage #> PDK4                 4.103037             2.220642             3.512728 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  0.000000             0.000000             0.000000 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             0.000000 #>          X51_Y-67..Macrophage X52_Y-67..Macrophage X49_Y-64..Macrophage #> PDK4                1.3467580            1.8651286             2.227792 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.0000000            0.0000000             0.000000 #> GZMB                0.2285623            0.2666561             1.886991 #> TSC2                0.2481084            0.2894598             0.000000 #>          X51_Y-66..Macrophage X40_Y-79..Macrophage X42_Y-79..Macrophage #> PDK4                        0             3.987317              2.62049 #> TNFRSF17                    0             0.000000              0.00000 #> ICAM3                       0             0.000000              0.00000 #> FAP                         0             0.000000              0.00000 #> GZMB                        0             0.000000              0.00000 #> TSC2                        0             0.000000              0.00000 #>          X37_Y-80..Macrophage X41_Y-80..Macrophage X40_Y-80..Macrophage #> PDK4                        0                    0             0.000000 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             1.942008 #>          X39_Y-80..Macrophage X41_Y-81..Macrophage X37_Y-81..Macrophage #> PDK4                        0                    0              2.35427 #> TNFRSF17                    0                    0              0.00000 #> ICAM3                       0                    0              0.00000 #> FAP                         0                    0              0.00000 #> GZMB                        0                    0              0.00000 #> TSC2                        0                    0              0.00000 #>          X38_Y-81..Macrophage X42_Y-81..Macrophage X38_Y-82..Macrophage #> PDK4                 3.364981             1.237857              1.86864 #> TNFRSF17             0.000000             0.000000              0.00000 #> ICAM3                0.000000             0.000000              0.00000 #> FAP                  0.000000             0.000000              0.00000 #> GZMB                 0.000000             0.000000              0.00000 #> TSC2                 0.000000             0.000000              0.00000 #>          X40_Y-82..Macrophage X41_Y-82..Macrophage X36_Y-82..Macrophage #> PDK4                 2.740091             1.075788                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  0.000000             0.000000                    0 #> GZMB                 0.000000             1.506933                    0 #> TSC2                 0.000000             0.000000                    0 #>          X37_Y-82..Macrophage X38_Y-83..Macrophage X39_Y-83..Macrophage #> PDK4                 3.860974             3.737279                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  0.000000             0.000000                    0 #> GZMB                 0.000000             0.000000                    0 #> TSC2                 0.000000             0.000000                    0 #>          X41_Y-83..Macrophage X36_Y-83..Macrophage X40_Y-83..Macrophage #> PDK4                 1.614702            0.6265407             4.295383 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  0.000000            0.0000000             0.000000 #> GZMB                 0.000000            0.0000000             0.000000 #> TSC2                 0.000000            0.0000000             0.000000 #>          X37_Y-83..Macrophage X37_Y-84..Macrophage X39_Y-84..Macrophage #> PDK4                 1.039657             1.731857             3.029411 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  0.000000             0.000000             0.000000 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             0.000000 #>          X41_Y-84..Macrophage X36_Y-85..Macrophage X41_Y-85..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X40_Y-81..Macrophage X39_Y-82..Macrophage X36_Y-84..Macrophage #> PDK4                 0.000000             2.264917              0.00000 #> TNFRSF17             0.000000             0.000000              0.00000 #> ICAM3                0.000000             0.000000              0.00000 #> FAP                  0.000000             0.000000              0.00000 #> GZMB                 0.000000             0.000000              0.47842 #> TSC2                 1.942008             0.000000              0.00000 #>          X79_Y-69..Macrophage X45_Y-72..Macrophage X43_Y-73..Macrophage #> PDK4                        0                    0             1.096629 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X44_Y-73..Macrophage X46_Y-73..Macrophage X45_Y-73..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X47_Y-74..Macrophage X46_Y-74..Macrophage X48_Y-74..Macrophage #> PDK4                0.4697577             1.409273                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 0.0000000             0.000000                    0 #> GZMB                0.9479096             1.489428                    0 #> TSC2                0.0000000             0.000000                    0 #>          X43_Y-74..Macrophage X42_Y-74..Macrophage X47_Y-75..Macrophage #> PDK4                        0             4.940848            0.4148097 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             0.000000            0.0000000 #> GZMB                        0             0.000000            0.4514337 #> TSC2                        0             0.000000            0.0000000 #>          X43_Y-75..Macrophage X45_Y-75..Macrophage X46_Y-75..Macrophage #> PDK4                        0             2.181905             0.000000 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             0.000000             0.000000 #> GZMB                        0             1.319280             2.234142 #> TSC2                        0             0.000000             0.000000 #>          X42_Y-76..Macrophage X47_Y-76..Macrophage X44_Y-76..Macrophage #> PDK4                 4.233436            0.7703822                    0 #> TNFRSF17             0.000000            0.0000000                    0 #> ICAM3                0.000000            0.0000000                    0 #> FAP                  0.000000            0.0000000                    0 #> GZMB                 0.000000            0.0000000                    0 #> TSC2                 0.000000            0.0000000                    0 #>          X43_Y-77..Macrophage X47_Y-77..Macrophage X45_Y-78..Macrophage #> PDK4                        0             1.077327              1.76163 #> TNFRSF17                    0             0.000000              0.00000 #> ICAM3                       0             0.000000              0.00000 #> FAP                         0             0.000000              0.00000 #> GZMB                        0             0.000000              0.00000 #> TSC2                        0             0.000000              0.00000 #>          X47_Y-78..Macrophage X44_Y-78..Macrophage X46_Y-79..Macrophage #> PDK4                  0.00000                    0               0.4928 #> TNFRSF17              0.00000                    0               0.0000 #> ICAM3                 0.00000                    0               0.0000 #> FAP                   0.00000                    0               0.0000 #> GZMB                  1.08498                    0               0.0000 #> TSC2                  0.00000                    0               0.0000 #>          X47_Y-79..Macrophage X48_Y-72..Macrophage X47_Y-73..Macrophage #> PDK4                   0.4312            1.9229972                    0 #> TNFRSF17               0.0000            0.0000000                    0 #> ICAM3                  0.0000            0.0000000                    0 #> FAP                    0.0000            0.0000000                    0 #> GZMB                   0.0000            0.7472766                    0 #> TSC2                   0.0000            0.0000000                    0 #>          X46_Y-76..Macrophage X43_Y-78..Macrophage X74_Y-79..Macrophage #> PDK4                 1.925955             1.985932             4.494189 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  0.000000             0.000000             0.000000 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             4.494189 #>          X75_Y-80..Macrophage X76_Y-80..Macrophage X74_Y-80..Macrophage #> PDK4                 1.430077             1.003409             4.649974 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  0.000000             0.000000             0.000000 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             2.247095 #>          X76_Y-81..Macrophage X74_Y-81..Macrophage X78_Y-81..Macrophage #> PDK4                0.6689396                    0            0.7161321 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.0000000                    0            0.0000000 #> GZMB                0.0000000                    0            0.0000000 #> TSC2                0.0000000                    0            0.0000000 #>          X77_Y-81..Macrophage X73_Y-82..Macrophage X77_Y-82..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X78_Y-82..Macrophage X76_Y-82..Macrophage X76_Y-83..Macrophage #> PDK4                 1.291222             4.887178             5.273895 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  0.000000             0.000000             0.000000 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             0.000000 #>          X74_Y-83..Macrophage X75_Y-84..Macrophage X77_Y-84..Macrophage #> PDK4                        0             1.612094                    0 #> TNFRSF17                    0             0.000000                    0 #> ICAM3                       0             0.000000                    0 #> FAP                         0             0.000000                    0 #> GZMB                        0             0.000000                    0 #> TSC2                        0             1.612094                    0 #>          X74_Y-84..Macrophage X73_Y-85..Macrophage X77_Y-80..Macrophage #> PDK4                  1.20907                    0                    0 #> TNFRSF17              0.00000                    0                    0 #> ICAM3                 0.00000                    0                    0 #> FAP                   0.00000                    0                    0 #> GZMB                  0.00000                    0                    0 #> TSC2                  1.20907                    0                    0 #>          X75_Y-81..Macrophage X73_Y-81..Macrophage X78_Y-83..Macrophage #> PDK4                 2.145116                    0            0.9207134 #> TNFRSF17             0.000000                    0            0.0000000 #> ICAM3                0.000000                    0            0.0000000 #> FAP                  0.000000                    0            0.0000000 #> GZMB                 0.000000                    0            0.0000000 #> TSC2                 0.000000                    0            0.0000000 #>          X77_Y-85..Macrophage X74_Y-66..Macrophage X74_Y-67..Macrophage #> PDK4                        0            0.5188800            0.5299539 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.0000000            0.0000000 #> GZMB                        0            0.5188800            0.0000000 #> TSC2                        0            0.3800901            0.0000000 #>          X75_Y-67..Macrophage X77_Y-67..Macrophage X75_Y-68..Macrophage #> PDK4                1.0911639                    0            1.2825478 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.0000000                    0            0.0000000 #> GZMB                0.3338055                    0            0.3081281 #> TSC2                0.3611003                    0            0.5862004 #>          X77_Y-68..Macrophage X76_Y-68..Macrophage X78_Y-68..Macrophage #> PDK4                0.4940712             1.564201                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 0.0000000             0.000000                    0 #> GZMB                0.0000000             0.000000                    0 #> TSC2                0.0000000             0.000000                    0 #>          X74_Y-68..Macrophage X77_Y-69..Macrophage X78_Y-69..Macrophage #> PDK4                0.6944859                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 0.0000000                    0                    0 #> GZMB                0.0000000                    0                    0 #> TSC2                0.0000000                    0                    0 #>          X75_Y-69..Macrophage X76_Y-69..Macrophage X73_Y-69..Macrophage #> PDK4                0.5965257             1.226915            0.0000000 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.0000000             0.000000            0.0000000 #> GZMB                0.0000000             0.000000            0.4970848 #> TSC2                0.0000000             0.000000            0.0000000 #>          X74_Y-69..Macrophage X77_Y-70..Macrophage X76_Y-70..Macrophage #> PDK4                0.3240934                    0            0.7564669 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.0000000                    0            0.0000000 #> GZMB                0.2319729                    0            0.0000000 #> TSC2                0.0000000                    0            0.0000000 #>          X74_Y-70..Macrophage X78_Y-71..Macrophage X77_Y-71..Macrophage #> PDK4                        0             2.133611                    0 #> TNFRSF17                    0             0.000000                    0 #> ICAM3                       0             0.000000                    0 #> FAP                         0             0.000000                    0 #> GZMB                        0             0.000000                    0 #> TSC2                        0             0.000000                    0 #>          X74_Y-71..Macrophage X77_Y-72..Macrophage X74_Y-72..Macrophage #> PDK4                        0            0.6891369                    0 #> TNFRSF17                    0            0.0000000                    0 #> ICAM3                       0            0.0000000                    0 #> FAP                         0            0.0000000                    0 #> GZMB                        0            0.0000000                    0 #> TSC2                        0            0.0000000                    0 #>          X76_Y-73..Macrophage X76_Y-67..Macrophage X60_Y-67..Macrophage #> PDK4                  0.00000            0.6339231             1.573619 #> TNFRSF17              0.00000            0.0000000             0.000000 #> ICAM3                 0.00000            0.0000000             0.000000 #> FAP                   0.00000            0.0000000             0.000000 #> GZMB                  1.09251            0.0000000             0.000000 #> TSC2                  0.00000            0.0000000             0.000000 #>          X57_Y-67..Macrophage X57_Y-68..Macrophage X58_Y-69..Macrophage #> PDK4                 1.243104             1.243104             1.084434 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  0.000000             0.000000             0.000000 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             0.000000 #>          X57_Y-69..Macrophage X59_Y-70..Macrophage X55_Y-66..Macrophage #> PDK4                 1.675797             2.579847              0.00000 #> TNFRSF17             0.000000             0.000000              0.00000 #> ICAM3                0.000000             0.000000              0.00000 #> FAP                  0.000000             0.000000              0.00000 #> GZMB                 0.000000             0.000000              0.00000 #> TSC2                 0.000000             0.000000              1.09251 #>          X56_Y-67..Macrophage X59_Y-68..Macrophage X58_Y-72..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X47_Y-80..Macrophage X45_Y-80..Macrophage X43_Y-80..Macrophage #> PDK4                0.6487569                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 0.0000000                    0                    0 #> GZMB                0.0000000                    0                    0 #> TSC2                0.6487569                    0                    0 #>          X44_Y-81..Macrophage X46_Y-81..Macrophage X45_Y-81..Macrophage #> PDK4                 0.734317             1.268668             2.057258 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  0.000000             0.000000             0.000000 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             0.000000 #>          X47_Y-81..Macrophage X46_Y-82..Macrophage X45_Y-82..Macrophage #> PDK4                 1.171749            0.4331415            0.9817677 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.000000            0.0000000            0.0000000 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X44_Y-82..Macrophage X42_Y-82..Macrophage X47_Y-82..Macrophage #> PDK4                0.8081269               0.0000            0.4764556 #> TNFRSF17            0.0000000               0.0000            0.0000000 #> ICAM3               0.0000000               0.0000            0.0000000 #> FAP                 0.0000000               0.0000            0.0000000 #> GZMB                0.0000000               4.5208            0.0000000 #> TSC2                0.0000000               0.0000            0.0000000 #>          X46_Y-83..Macrophage X45_Y-83..Macrophage X44_Y-83..Macrophage #> PDK4                0.4374156             0.899262                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 0.0000000             0.000000                    0 #> GZMB                0.0000000             0.000000                    0 #> TSC2                0.0000000             0.000000                    0 #>          X44_Y-84..Macrophage X43_Y-84..Macrophage X45_Y-84..Macrophage #> PDK4                0.7999609            1.5193130                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.0000000            0.0000000                    0 #> GZMB                0.0000000            0.5362088                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X45_Y-85..Macrophage X44_Y-85..Macrophage X48_Y-85..Macrophage #> PDK4                0.4733172                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 0.0000000                    0                    0 #> GZMB                0.0000000                    0                    0 #> TSC2                0.4733172                    0                    0 #>          X46_Y-80..Macrophage X44_Y-80..Macrophage X43_Y-81..Macrophage #> PDK4                0.5165802                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 0.0000000                    0                    0 #> GZMB                0.0000000                    0                    0 #> TSC2                0.0000000                    0                    0 #>          X43_Y-82..Macrophage X43_Y-83..Macrophage X47_Y-83..Macrophage #> PDK4                0.6926802            0.9455837             1.312247 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.0000000            0.0000000             0.000000 #> GZMB                0.0000000            1.0724177             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X51_Y-92..Macrophage X49_Y-92..Macrophage X52_Y-92..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X50_Y-93..Macrophage X53_Y-93..Macrophage X51_Y-94..Macrophage #> PDK4                0.0000000            0.7789529                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.0000000            0.0000000                    0 #> GZMB                0.0000000            0.0000000                    0 #> TSC2                0.9652436            0.0000000                    0 #>          X49_Y-94..Macrophage X49_Y-96..Macrophage X52_Y-96..Macrophage #> PDK4                        0             1.107601                    0 #> TNFRSF17                    0             0.000000                    0 #> ICAM3                       0             0.000000                    0 #> FAP                         0             0.000000                    0 #> GZMB                        0             0.000000                    0 #> TSC2                        0             0.000000                    0 #>          X51_Y-97..Macrophage X54_Y-97..Macrophage X51_Y-91..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X50_Y-92..Macrophage X55_Y-93..Macrophage X54_Y-94..Macrophage #> PDK4                        0             1.231419             1.092757 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             0.000000             0.000000 #> GZMB                        0             0.000000             2.297221 #> TSC2                        0             0.000000             0.000000 #>          X53_Y-96..Macrophage X53_Y-97..Macrophage X69_Y-79..Macrophage #> PDK4                 1.735247             3.470495                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  0.000000             0.000000                    0 #> GZMB                 0.000000             0.000000                    0 #> TSC2                 0.000000             0.000000                    0 #>          X71_Y-80..Macrophage X68_Y-80..Macrophage X70_Y-81..Macrophage #> PDK4                0.8298395             3.545876                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 0.0000000             0.000000                    0 #> GZMB                0.3961696             0.000000                    0 #> TSC2                0.3961696             0.000000                    0 #>          X72_Y-82..Macrophage X71_Y-82..Macrophage X70_Y-82..Macrophage #> PDK4                        0            0.5563994            0.3709329 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.0000000            0.0000000 #> GZMB                        0            0.6195804            0.4130536 #> TSC2                        0            0.5563994            0.3709329 #>          X68_Y-83..Macrophage X71_Y-83..Macrophage X70_Y-83..Macrophage #> PDK4                        0             0.000000             1.238055 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             0.000000             0.000000 #> GZMB                        0             2.137791             0.000000 #> TSC2                        0             0.000000             0.000000 #>          X71_Y-84..Macrophage X68_Y-84..Macrophage X69_Y-84..Macrophage #> PDK4                 0.000000            1.2572428             1.898214 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  0.000000            0.0000000             0.000000 #> GZMB                 1.425194            0.2679326             1.123704 #> TSC2                 0.000000            0.0000000             0.000000 #>          X72_Y-84..Macrophage X67_Y-84..Macrophage X66_Y-84..Macrophage #> PDK4                 0.000000            1.1099815            0.6286768 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.000000            0.0000000            0.0000000 #> GZMB                 1.387668            0.5199874            0.2430336 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X68_Y-85..Macrophage X67_Y-85..Macrophage X70_Y-85..Macrophage #> PDK4                0.9548799             1.540507             1.640062 #> TNFRSF17            0.0000000             0.000000             0.000000 #> ICAM3               0.0000000             0.000000             0.000000 #> FAP                 0.0000000             0.000000             0.000000 #> GZMB                0.2679326             0.000000             0.000000 #> TSC2                0.0000000             0.000000             0.000000 #>          X71_Y-81..Macrophage X72_Y-81..Macrophage X70_Y-84..Macrophage #> PDK4                 0.000000                    0             2.138244 #> TNFRSF17             0.000000                    0             0.000000 #> ICAM3                0.000000                    0             0.000000 #> FAP                  0.000000                    0             0.000000 #> GZMB                 1.980848                    0             0.000000 #> TSC2                 1.980848                    0             0.000000 #>          X72_Y-85..Macrophage X50_Y-67..Macrophage X52_Y-68..Macrophage #> PDK4                 0.000000            0.7197459            0.0000000 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.000000            0.0000000            0.0000000 #> GZMB                 2.775336            0.0000000            0.5466230 #> TSC2                 0.000000            0.6303891            0.6544827 #>          X51_Y-68..Macrophage X53_Y-68..Macrophage X50_Y-68..Macrophage #> PDK4                0.6991793            0.0000000             0.000000 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.0000000            0.0000000             0.000000 #> GZMB                0.0000000            0.6719207             0.000000 #> TSC2                0.2643641            0.6719207             3.814873 #>          X51_Y-69..Macrophage X54_Y-69..Macrophage X50_Y-69..Macrophage #> PDK4                0.9089739                    0             2.532002 #> TNFRSF17            0.0000000                    0             0.000000 #> ICAM3               0.0000000                    0             0.000000 #> FAP                 0.0000000                    0             0.000000 #> GZMB                0.0000000                    0             0.000000 #> TSC2                0.0000000                    0             0.000000 #>          X52_Y-69..Macrophage X50_Y-70..Macrophage X51_Y-70..Macrophage #> PDK4                 1.605711            0.5450324             1.555727 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  0.000000            0.0000000             0.000000 #> GZMB                 0.000000            0.0000000             0.270124 #> TSC2                 0.000000            0.0000000             0.000000 #>          X52_Y-70..Macrophage X51_Y-71..Macrophage X52_Y-71..Macrophage #> PDK4                 2.264075            0.5947745            1.4654796 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.000000            0.0000000            0.0000000 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.4646853 #>          X53_Y-72..Macrophage X49_Y-69..Macrophage X53_Y-71..Macrophage #> PDK4                 1.631243             2.123871                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  0.000000             0.000000                    0 #> GZMB                 1.367679             0.000000                    0 #> TSC2                 0.000000             0.000000                    0 #>          X51_Y-72..Macrophage X66_Y-64..Macrophage X64_Y-64..Macrophage #> PDK4                 0.000000            0.0000000             1.249362 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  0.000000            0.0000000             0.000000 #> GZMB                 1.243104            0.0000000             0.000000 #> TSC2                 0.000000            0.6520692             0.000000 #>          X64_Y-65..Macrophage X61_Y-65..Macrophage X65_Y-65..Macrophage #> PDK4                 1.249362             1.391988                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  0.000000             0.000000                    0 #> GZMB                 0.000000             0.000000                    0 #> TSC2                 0.000000             0.000000                    0 #>          X61_Y-64..Macrophage X66_Y-65..Macrophage X55_Y-79..Macrophage #> PDK4                 1.391988            0.0000000                    0 #> TNFRSF17             0.000000            0.0000000                    0 #> ICAM3                0.000000            0.0000000                    0 #> FAP                  0.000000            0.0000000                    0 #> GZMB                 0.000000            0.0000000                    0 #> TSC2                 0.000000            0.4890519                    0 #>          X59_Y-79..Macrophage X57_Y-79..Macrophage X61_Y-79..Macrophage #> PDK4                 2.016249             1.904192                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  0.000000             0.000000                    0 #> GZMB                 0.000000             0.000000                    0 #> TSC2                 0.000000             0.000000                    0 #>          X57_Y-80..Macrophage X58_Y-80..Macrophage X55_Y-80..Macrophage #> PDK4                 2.705544                    0            0.8665309 #> TNFRSF17             0.000000                    0            0.0000000 #> ICAM3                0.000000                    0            0.0000000 #> FAP                  0.000000                    0            0.0000000 #> GZMB                 0.000000                    0            0.0000000 #> TSC2                 0.000000                    0            0.0000000 #>          X60_Y-80..Macrophage X59_Y-80..Macrophage X56_Y-80..Macrophage #> PDK4                        0                    0             1.904192 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X55_Y-81..Macrophage X59_Y-81..Macrophage X57_Y-81..Macrophage #> PDK4                        0            0.3096855             1.927192 #> TNFRSF17                    0            0.0000000             0.000000 #> ICAM3                       0            0.0000000             0.000000 #> FAP                         0            0.0000000             0.000000 #> GZMB                        0            0.0000000             0.000000 #> TSC2                        0            0.0000000             0.000000 #>          X58_Y-81..Macrophage X61_Y-81..Macrophage X58_Y-82..Macrophage #> PDK4                0.0000000                    0            0.0000000 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.0000000                    0            0.0000000 #> GZMB                0.6497364                    0            0.5685193 #> TSC2                0.0000000                    0            0.0000000 #>          X54_Y-82..Macrophage X59_Y-82..Macrophage X55_Y-82..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X57_Y-82..Macrophage X56_Y-82..Macrophage X56_Y-83..Macrophage #> PDK4                1.2137653            1.1549744            0.5256183 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            0.0000000            0.0000000 #> GZMB                0.9733472            0.5561984            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X55_Y-83..Macrophage X60_Y-83..Macrophage X57_Y-83..Macrophage #> PDK4                0.7119445                    0            0.6068826 #> TNFRSF17            0.0000000                    0            0.0000000 #> ICAM3               0.0000000                    0            0.0000000 #> FAP                 0.0000000                    0            0.0000000 #> GZMB                0.0000000                    0            0.0000000 #> TSC2                0.0000000                    0            0.3122763 #>          X54_Y-84..Macrophage X57_Y-84..Macrophage X56_Y-84..Macrophage #> PDK4                0.7769025                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 0.0000000                    0                    0 #> GZMB                0.0000000                    0                    0 #> TSC2                0.0000000                    0                    0 #>          X58_Y-84..Macrophage X59_Y-84..Macrophage X57_Y-85..Macrophage #> PDK4                        0             2.219452                    0 #> TNFRSF17                    0             0.000000                    0 #> ICAM3                       0             0.000000                    0 #> FAP                         0             0.000000                    0 #> GZMB                        0             0.000000                    0 #> TSC2                        0             0.000000                    0 #>          X58_Y-85..Macrophage X60_Y-85..Macrophage X55_Y-85..Macrophage #> PDK4                 1.946694             0.782483              1.48217 #> TNFRSF17             0.000000             0.000000              0.00000 #> ICAM3                0.000000             0.000000              0.00000 #> FAP                  0.000000             0.000000              0.00000 #> GZMB                 0.000000             0.000000              0.00000 #> TSC2                 1.717478             0.000000              0.00000 #>          X54_Y-80..Macrophage X60_Y-81..Macrophage X58_Y-83..Macrophage #> PDK4                 1.090828            0.5806603                    0 #> TNFRSF17             0.000000            0.0000000                    0 #> ICAM3                0.000000            0.0000000                    0 #> FAP                  0.000000            0.0000000                    0 #> GZMB                 0.000000            0.0000000                    0 #> TSC2                 0.000000            0.0000000                    0 #>          X55_Y-84..Macrophage X56_Y-85..Macrophage X65_Y-80..Macrophage #> PDK4                 1.553805            0.9686831                    0 #> TNFRSF17             0.000000            0.0000000                    0 #> ICAM3                0.000000            0.0000000                    0 #> FAP                  0.000000            0.0000000                    0 #> GZMB                 0.000000            0.0000000                    0 #> TSC2                 0.000000            0.0000000                    0 #>          X66_Y-82..Macrophage X65_Y-82..Macrophage X63_Y-82..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X61_Y-82..Macrophage X66_Y-83..Macrophage X61_Y-83..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X64_Y-83..Macrophage X63_Y-83..Macrophage X62_Y-83..Macrophage #> PDK4                        0             0.653492            0.3713572 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             0.000000            0.0000000 #> GZMB                        0             0.000000            0.3795001 #> TSC2                        0             0.000000            0.0000000 #>          X63_Y-84..Macrophage X62_Y-84..Macrophage X61_Y-84..Macrophage #> PDK4                0.3805688            0.8965053               0.0000 #> TNFRSF17            0.0000000            0.0000000               0.0000 #> ICAM3               0.0000000            0.0000000               0.0000 #> FAP                 0.0000000            0.0000000               0.0000 #> GZMB                0.0000000            0.2919231               1.8975 #> TSC2                0.0000000            0.0000000               0.0000 #>          X65_Y-84..Macrophage X64_Y-84..Macrophage X65_Y-85..Macrophage #> PDK4                        0                    0            0.2815873 #> TNFRSF17                    0                    0            0.0000000 #> ICAM3                       0                    0            0.0000000 #> FAP                         0                    0            0.0000000 #> GZMB                        0                    0            0.0000000 #> TSC2                        0                    0            0.0000000 #>          X63_Y-85..Macrophage X66_Y-85..Macrophage X64_Y-85..Macrophage #> PDK4                0.4138814            1.3142893            0.4598682 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            0.0000000            0.0000000 #> GZMB                0.0000000            0.2971418            0.0000000 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X63_Y-81..Macrophage X62_Y-85..Macrophage X36_Y-91..Macrophage #> PDK4                 4.378773              1.16648            0.6801428 #> TNFRSF17             0.000000              0.00000            0.0000000 #> ICAM3                0.000000              0.00000            0.0000000 #> FAP                  0.000000              0.00000            0.0000000 #> GZMB                 0.000000              0.00000            0.0000000 #> TSC2                 0.000000              0.00000            0.8482456 #>          X35_Y-91..Macrophage X32_Y-91..Macrophage X35_Y-92..Macrophage #> PDK4                 0.845326                    0             1.615194 #> TNFRSF17             0.000000                    0             0.000000 #> ICAM3                0.000000                    0             0.000000 #> FAP                  0.000000                    0             0.000000 #> GZMB                 0.000000                    0             0.000000 #> TSC2                 0.000000                    0             0.000000 #>          X34_Y-92..Macrophage X32_Y-93..Macrophage X30_Y-93..Macrophage #> PDK4                  1.02649                    0             1.832073 #> TNFRSF17              0.00000                    0             0.000000 #> ICAM3                 0.00000                    0             0.000000 #> FAP                   0.00000                    0             0.000000 #> GZMB                  0.00000                    0             0.000000 #> TSC2                  0.00000                    0             0.000000 #>          X35_Y-93..Macrophage X31_Y-93..Macrophage X33_Y-93..Macrophage #> PDK4                0.9123604                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 0.0000000                    0                    0 #> GZMB                0.0000000                    0                    0 #> TSC2                0.0000000                    0                    0 #>          X34_Y-93..Macrophage X31_Y-94..Macrophage X34_Y-94..Macrophage #> PDK4                 1.514592             1.062001             1.298222 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  0.000000             0.000000             0.000000 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             0.000000 #>          X30_Y-94..Macrophage X35_Y-94..Macrophage X32_Y-94..Macrophage #> PDK4                 3.956074             3.628044                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  0.000000             0.000000                    0 #> GZMB                 0.000000             0.000000                    0 #> TSC2                 0.000000             0.000000                    0 #>          X31_Y-95..Macrophage X32_Y-95..Macrophage X30_Y-95..Macrophage #> PDK4                        0             3.181991                    0 #> TNFRSF17                    0             0.000000                    0 #> ICAM3                       0             0.000000                    0 #> FAP                         0             0.000000                    0 #> GZMB                        0             0.000000                    0 #> TSC2                        0             0.000000                    0 #>          X33_Y-95..Macrophage X31_Y-96..Macrophage X33_Y-96..Macrophage #> PDK4                 2.283413             2.513632             1.522275 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  0.000000             0.000000             0.000000 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             0.000000 #>          X34_Y-96..Macrophage X36_Y-96..Macrophage X30_Y-97..Macrophage #> PDK4                        0            0.9098643                    0 #> TNFRSF17                    0            0.0000000                    0 #> ICAM3                       0            0.0000000                    0 #> FAP                         0            0.0000000                    0 #> GZMB                        0            0.0000000                    0 #> TSC2                        0            0.0000000                    0 #>          X35_Y-97..Macrophage X31_Y-97..Macrophage X34_Y-91..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X34_Y-95..Macrophage X35_Y-95..Macrophage X33_Y-97..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X43_Y-85..Macrophage X45_Y-86..Macrophage X44_Y-86..Macrophage #> PDK4                 2.107297            0.6310897                    0 #> TNFRSF17             0.000000            0.0000000                    0 #> ICAM3                0.000000            0.0000000                    0 #> FAP                  0.000000            0.0000000                    0 #> GZMB                 0.000000            0.0000000                    0 #> TSC2                 0.000000            0.6310897                    0 #>          X47_Y-86..Macrophage X47_Y-87..Macrophage X46_Y-87..Macrophage #> PDK4                 1.173358             1.197144            1.3121289 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  0.000000             0.000000            0.0000000 #> GZMB                 0.000000             0.000000            0.3213693 #> TSC2                 0.000000             0.000000            0.0000000 #>          X42_Y-87..Macrophage X45_Y-87..Macrophage X45_Y-88..Macrophage #> PDK4                        0            0.3007899            0.2455913 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.0000000            0.0000000 #> GZMB                        0            0.2570955            0.0000000 #> TSC2                        0            0.0000000            0.0000000 #>          X46_Y-88..Macrophage X47_Y-88..Macrophage X48_Y-88..Macrophage #> PDK4                 1.173258            1.3771630             1.449386 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  0.000000            0.0000000             0.000000 #> GZMB                 0.000000            0.6360818             0.000000 #> TSC2                 0.000000            0.6360818             0.000000 #>          X44_Y-88..Macrophage X45_Y-89..Macrophage X46_Y-89..Macrophage #> PDK4                 1.546716            0.4720003            0.8412262 #> TNFRSF17             0.000000            0.0000000            0.0000000 #> ICAM3                0.000000            0.0000000            0.0000000 #> FAP                  0.000000            0.0000000            0.0000000 #> GZMB                 0.000000            0.0000000            0.0000000 #> TSC2                 0.000000            0.0000000            0.0000000 #>          X47_Y-89..Macrophage X44_Y-89..Macrophage X42_Y-89..Macrophage #> PDK4                0.6839841                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 0.0000000                    0                    0 #> GZMB                0.5452129                    0                    0 #> TSC2                0.5452129                    0                    0 #>          X45_Y-90..Macrophage X44_Y-90..Macrophage X47_Y-90..Macrophage #> PDK4                        0                    0            1.7925858 #> TNFRSF17                    0                    0            0.0000000 #> ICAM3                       0                    0            0.0000000 #> FAP                         0                    0            0.0000000 #> GZMB                        0                    0            0.3052174 #> TSC2                        0                    0            0.0000000 #>          X43_Y-90..Macrophage X46_Y-90..Macrophage X42_Y-90..Macrophage #> PDK4                0.0000000            1.6208795            0.6835998 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            0.0000000            0.0000000 #> GZMB                0.0000000            0.3391304            0.3899701 #> TSC2                0.6757949            0.0000000            0.4300513 #>          X46_Y-91..Macrophage X45_Y-91..Macrophage X48_Y-86..Macrophage #> PDK4                        0             1.343260            0.8800182 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             0.000000            0.0000000 #> GZMB                        0             1.118085            0.0000000 #> TSC2                        0             0.000000            0.0000000 #>          X48_Y-89..Macrophage X49_Y-80..Macrophage X50_Y-80..Macrophage #> PDK4                 1.196972             0.804527                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  0.000000             0.000000                    0 #> GZMB                 0.000000             0.000000                    0 #> TSC2                 0.000000             0.000000                    0 #>          X51_Y-80..Macrophage X52_Y-80..Macrophage X48_Y-80..Macrophage #> PDK4                 1.286015             1.560655                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  0.000000             0.000000                    0 #> GZMB                 0.000000             0.000000                    0 #> TSC2                 0.000000             0.000000                    0 #>          X53_Y-81..Macrophage X50_Y-81..Macrophage X52_Y-81..Macrophage #> PDK4                0.8507498                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 0.0000000                    0                    0 #> GZMB                0.0000000                    0                    0 #> TSC2                0.0000000                    0                    0 #>          X54_Y-81..Macrophage X51_Y-81..Macrophage X53_Y-82..Macrophage #> PDK4                        0                    0            0.7165094 #> TNFRSF17                    0                    0            0.0000000 #> ICAM3                       0                    0            0.0000000 #> FAP                         0                    0            0.0000000 #> GZMB                        0                    0            0.0000000 #> TSC2                        0                    0            0.0000000 #>          X51_Y-82..Macrophage X52_Y-82..Macrophage X54_Y-83..Macrophage #> PDK4                0.5127672                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 0.0000000                    0                    0 #> GZMB                0.0000000                    0                    0 #> TSC2                0.0000000                    0                    0 #>          X49_Y-83..Macrophage X52_Y-83..Macrophage X51_Y-83..Macrophage #> PDK4                        0            0.6397457             1.061121 #> TNFRSF17                    0            0.0000000             0.000000 #> ICAM3                       0            0.0000000             0.000000 #> FAP                         0            0.0000000             0.000000 #> GZMB                        0            0.0000000             0.574910 #> TSC2                        0            0.0000000             0.000000 #>          X51_Y-84..Macrophage X53_Y-84..Macrophage X52_Y-84..Macrophage #> PDK4                0.3021049             1.262179                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 0.0000000             0.000000                    0 #> GZMB                0.3021049             0.000000                    0 #> TSC2                0.0000000             1.262179                    0 #>          X52_Y-85..Macrophage X51_Y-85..Macrophage X53_Y-80..Macrophage #> PDK4                        0                    0             1.648775 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X49_Y-85..Macrophage X69_Y-92..Macrophage X67_Y-93..Macrophage #> PDK4                        0             2.247095                    0 #> TNFRSF17                    0             0.000000                    0 #> ICAM3                       0             0.000000                    0 #> FAP                         0             0.000000                    0 #> GZMB                        0             0.000000                    0 #> TSC2                        0             0.000000                    0 #>          X70_Y-93..Macrophage X66_Y-94..Macrophage X68_Y-96..Macrophage #> PDK4                        0                    0              0.00000 #> TNFRSF17                    0                    0              0.00000 #> ICAM3                       0                    0              0.00000 #> FAP                         0                    0              0.00000 #> GZMB                        0                    0              2.25149 #> TSC2                        0                    0              0.00000 #>          X71_Y-92..Macrophage X69_Y-93..Macrophage X69_Y-96..Macrophage #> PDK4                        0                    0             0.000000 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             1.500993 #> TSC2                        0                    0             0.000000 #>          X24_Y-65..Macrophage X26_Y-65..Macrophage X23_Y-66..Macrophage #> PDK4                 2.170562                    0                    0 #> TNFRSF17             0.000000                    0                    0 #> ICAM3                0.000000                    0                    0 #> FAP                  0.000000                    0                    0 #> GZMB                 0.000000                    0                    0 #> TSC2                 0.000000                    0                    0 #>          X28_Y-67..Macrophage X73_Y-92..Macrophage X78_Y-92..Macrophage #> PDK4                 2.127412                    0                    0 #> TNFRSF17             0.000000                    0                    0 #> ICAM3                0.000000                    0                    0 #> FAP                  0.000000                    0                    0 #> GZMB                 0.000000                    0                    0 #> TSC2                 0.000000                    0                    0 #>          X75_Y-92..Macrophage X78_Y-93..Macrophage X77_Y-93..Macrophage #> PDK4                  4.44265             4.443386             2.009494 #> TNFRSF17              0.00000             0.000000             0.000000 #> ICAM3                 0.00000             0.000000             0.000000 #> FAP                   0.00000             0.000000             0.000000 #> GZMB                  0.00000             0.000000             0.000000 #> TSC2                  0.00000             0.000000             0.000000 #>          X79_Y-93..Macrophage X74_Y-93..Macrophage X78_Y-94..Macrophage #> PDK4                 4.163422                    0                    0 #> TNFRSF17             0.000000                    0                    0 #> ICAM3                0.000000                    0                    0 #> FAP                  0.000000                    0                    0 #> GZMB                 0.000000                    0                    0 #> TSC2                 0.000000                    0                    0 #>          X77_Y-96..Macrophage X76_Y-96..Macrophage X76_Y-97..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X74_Y-91..Macrophage X76_Y-93..Macrophage X74_Y-94..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X75_Y-94..Macrophage X45_Y-67..Macrophage X47_Y-67..Macrophage #> PDK4                        0             3.397916            1.1369178 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             0.000000            0.0000000 #> GZMB                        0             0.000000            0.0000000 #> TSC2                        0             0.000000            0.5386708 #>          X47_Y-68..Macrophage X43_Y-68..Macrophage X46_Y-68..Macrophage #> PDK4                 4.005306             1.427534            0.4765399 #> TNFRSF17             0.000000             0.000000            0.0000000 #> ICAM3                0.000000             0.000000            0.0000000 #> FAP                  0.000000             0.000000            0.0000000 #> GZMB                 0.000000             0.000000            0.0000000 #> TSC2                 0.000000             0.000000            0.0000000 #>          X45_Y-69..Macrophage X44_Y-69..Macrophage X47_Y-69..Macrophage #> PDK4                 1.385737                    0             3.183312 #> TNFRSF17             0.000000                    0             0.000000 #> ICAM3                0.000000                    0             0.000000 #> FAP                  0.000000                    0             0.000000 #> GZMB                 0.000000                    0             1.661037 #> TSC2                 0.000000                    0             0.000000 #>          X43_Y-70..Macrophage X45_Y-70..Macrophage X42_Y-70..Macrophage #> PDK4                        0             3.180686             3.569047 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             0.000000             0.000000 #> GZMB                        0             0.000000             0.000000 #> TSC2                        0             0.000000             0.000000 #>          X44_Y-70..Macrophage X44_Y-71..Macrophage X47_Y-71..Macrophage #> PDK4                 2.343499                    0             2.343499 #> TNFRSF17             0.000000                    0             0.000000 #> ICAM3                0.000000                    0             0.000000 #> FAP                  0.000000                    0             0.000000 #> GZMB                 0.000000                    0             0.000000 #> TSC2                 0.000000                    0             0.000000 #>          X43_Y-71..Macrophage X48_Y-71..Macrophage X44_Y-72..Macrophage #> PDK4                  2.19329             3.513731                    0 #> TNFRSF17              0.00000             0.000000                    0 #> ICAM3                 0.00000             0.000000                    0 #> FAP                   0.00000             0.000000                    0 #> GZMB                  0.00000             0.000000                    0 #> TSC2                  0.00000             0.000000                    0 #>          X47_Y-72..Macrophage X43_Y-72..Macrophage X48_Y-67..Macrophage #> PDK4                        0             3.883364                    0 #> TNFRSF17                    0             0.000000                    0 #> ICAM3                       0             0.000000                    0 #> FAP                         0             0.000000                    0 #> GZMB                        0             0.000000                    0 #> TSC2                        0             0.000000                    0 #>          X48_Y-70..Macrophage X74_Y-65..Macrophage X73_Y-65..Macrophage #> PDK4                        0            0.0000000            0.7872996 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.0000000            0.0000000 #> GZMB                        0            0.5356225            0.0000000 #> TSC2                        0            0.0000000            0.3668385 #>          X78_Y-65..Macrophage X72_Y-66..Macrophage X23_Y-91..Macrophage #> PDK4                        0            1.1994749             4.071364 #> TNFRSF17                    0            0.0000000             0.000000 #> ICAM3                       0            0.0000000             0.000000 #> FAP                         0            0.0000000             0.000000 #> GZMB                        0            0.0000000             0.000000 #> TSC2                        0            0.4039133             0.000000 #>          X22_Y-93..Macrophage X22_Y-94..Macrophage X22_Y-95..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X23_Y-96..Macrophage X23_Y-97..Macrophage X23_Y-85..Macrophage #> PDK4                        0             4.621654             2.120614 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             0.000000             0.000000 #> GZMB                        0             1.278012             0.000000 #> TSC2                        0             0.000000             0.000000 #>          X25_Y-86..Macrophage X24_Y-86..Macrophage X27_Y-88..Macrophage #> PDK4                        0              2.72096                    0 #> TNFRSF17                    0              0.00000                    0 #> ICAM3                       0              0.00000                    0 #> FAP                         0              0.00000                    0 #> GZMB                        0              0.00000                    0 #> TSC2                        0              0.00000                    0 #>          X27_Y-89..Macrophage X24_Y-89..Macrophage X24_Y-90..Macrophage #> PDK4                 1.651578                    0                    0 #> TNFRSF17             0.000000                    0                    0 #> ICAM3                0.000000                    0                    0 #> FAP                  0.000000                    0                    0 #> GZMB                 0.000000                    0                    0 #> TSC2                 0.000000                    0                    0 #>          X24_Y-91..Macrophage X24_Y-87..Macrophage X27_Y-90..Macrophage #> PDK4                        0              2.72096                    0 #> TNFRSF17                    0              0.00000                    0 #> ICAM3                       0              0.00000                    0 #> FAP                         0              0.00000                    0 #> GZMB                        0              0.00000                    0 #> TSC2                        0              0.00000                    0 #>          X27_Y-91..Macrophage X35_Y-85..Macrophage X34_Y-85..Macrophage #> PDK4                        0             1.891167             3.782335 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             0.000000             0.000000 #> GZMB                        0             0.000000             0.000000 #> TSC2                        0             0.000000             0.000000 #>          X33_Y-86..Macrophage X35_Y-86..Macrophage X35_Y-87..Macrophage #> PDK4                        0             1.786649               1.8975 #> TNFRSF17                    0             0.000000               0.0000 #> ICAM3                       0             0.000000               0.0000 #> FAP                         0             0.000000               0.0000 #> GZMB                        0             0.000000               0.0000 #> TSC2                        0             0.000000               0.0000 #>          X36_Y-88..Macrophage X36_Y-89..Macrophage X35_Y-90..Macrophage #> PDK4                 2.239189            0.8544196                    0 #> TNFRSF17             0.000000            0.0000000                    0 #> ICAM3                0.000000            0.0000000                    0 #> FAP                  0.000000            0.0000000                    0 #> GZMB                 0.000000            0.0000000                    0 #> TSC2                 0.000000            0.0000000                    0 #>          X33_Y-87..Macrophage X33_Y-88..Macrophage X33_Y-89..Macrophage #> PDK4                        0                    0              4.12076 #> TNFRSF17                    0                    0              0.00000 #> ICAM3                       0                    0              0.00000 #> FAP                         0                    0              0.00000 #> GZMB                        0                    0              0.00000 #> TSC2                        0                    0              0.00000 #>          X34_Y-90..Macrophage X41_Y-86..Macrophage X38_Y-86..Macrophage #> PDK4                        0                    0             0.000000 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             3.631375 #> TSC2                        0                    0             0.000000 #>          X36_Y-87..Macrophage X40_Y-88..Macrophage X41_Y-89..Macrophage #> PDK4                  3.29989                    0             1.781184 #> TNFRSF17              0.00000                    0             0.000000 #> ICAM3                 0.00000                    0             0.000000 #> FAP                   0.00000                    0             0.000000 #> GZMB                  0.00000                    0             0.000000 #> TSC2                  0.00000                    0             0.000000 #>          X37_Y-89..Macrophage X38_Y-89..Macrophage X36_Y-90..Macrophage #> PDK4                        0                    0             1.020861 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X38_Y-91..Macrophage X37_Y-91..Macrophage X41_Y-90..Macrophage #> PDK4                        0             1.239161                    0 #> TNFRSF17                    0             0.000000                    0 #> ICAM3                       0             0.000000                    0 #> FAP                         0             0.000000                    0 #> GZMB                        0             0.000000                    0 #> TSC2                        0             1.413743                    0 #>          X39_Y-90..Macrophage X34_Y-97..Macrophage X34_Y-98..Macrophage #> PDK4                        0                    0             2.817592 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X30_Y-98..Macrophage X32_Y-98..Macrophage X34_Y-99..Macrophage #> PDK4                        0                    0             1.244429 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X32_Y-99..Macrophage X35_Y-99..Macrophage X31_Y-99..Macrophage #> PDK4                 1.677227                    0                    0 #> TNFRSF17             0.000000                    0                    0 #> ICAM3                0.000000                    0                    0 #> FAP                  0.000000                    0                    0 #> GZMB                 0.000000                    0                    0 #> TSC2                 0.000000                    0                    0 #>          X33_Y-99..Macrophage X33_Y-100..Macrophage X32_Y-100..Macrophage #> PDK4                  2.60906               2.60906              4.144908 #> TNFRSF17              0.00000               0.00000              0.000000 #> ICAM3                 0.00000               0.00000              0.000000 #> FAP                   0.00000               0.00000              0.000000 #> GZMB                  0.00000               0.00000              0.000000 #> TSC2                  0.00000               0.00000              0.000000 #>          X35_Y-100..Macrophage X34_Y-100..Macrophage X31_Y-101..Macrophage #> PDK4                  2.005043                     0              3.059201 #> TNFRSF17              0.000000                     0              0.000000 #> ICAM3                 0.000000                     0              0.000000 #> FAP                   0.000000                     0              0.000000 #> GZMB                  0.000000                     0              0.000000 #> TSC2                  0.000000                     0              0.000000 #>          X32_Y-101..Macrophage X30_Y-102..Macrophage X32_Y-103..Macrophage #> PDK4                         0              1.869855              1.476806 #> TNFRSF17                     0              0.000000              0.000000 #> ICAM3                        0              0.000000              0.000000 #> FAP                          0              0.000000              0.000000 #> GZMB                         0              0.000000              0.000000 #> TSC2                         0              0.000000              0.000000 #>          X31_Y-103..Macrophage X30_Y-103..Macrophage X33_Y-103..Macrophage #> PDK4                 0.7974152              1.139165             0.8027275 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.0000000              0.000000             0.0000000 #> GZMB                 0.0000000              0.000000             0.0000000 #> TSC2                 0.0000000              0.000000             0.0000000 #>          X34_Y-103..Macrophage X29_Y-103..Macrophage X31_Y-100..Macrophage #> PDK4                         0                     0                     0 #> TNFRSF17                     0                     0                     0 #> ICAM3                        0                     0                     0 #> FAP                          0                     0                     0 #> GZMB                         0                     0                     0 #> TSC2                         0                     0                     0 #>          X30_Y-101..Macrophage X22_Y-85..Macrophage X23_Y-86..Macrophage #> PDK4                  3.302477                    0             1.413743 #> TNFRSF17              0.000000                    0             0.000000 #> ICAM3                 0.000000                    0             0.000000 #> FAP                   0.000000                    0             0.000000 #> GZMB                  0.000000                    0             0.000000 #> TSC2                  0.000000                    0             0.000000 #>          X22_Y-86..Macrophage X21_Y-87..Macrophage X22_Y-88..Macrophage #> PDK4                        0             1.963114             1.963114 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             0.000000             0.000000 #> GZMB                        0             0.000000             0.000000 #> TSC2                        0             0.000000             0.000000 #>          X24_Y-88..Macrophage X23_Y-64..Macrophage X23_Y-65..Macrophage #> PDK4                 3.874733                    0                    0 #> TNFRSF17             0.000000                    0                    0 #> ICAM3                0.000000                    0                    0 #> FAP                  0.000000                    0                    0 #> GZMB                 0.000000                    0                    0 #> TSC2                 0.000000                    0                    0 #>          X22_Y-98..Macrophage X23_Y-98..Macrophage X22_Y-99..Macrophage #> PDK4                        0                    0             0.000000 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             2.104024 #>          X23_Y-99..Macrophage X23_Y-100..Macrophage X23_Y-101..Macrophage #> PDK4                        0              3.444907               3.52326 #> TNFRSF17                    0              0.000000               0.00000 #> ICAM3                       0              0.000000               0.00000 #> FAP                         0              0.000000               0.00000 #> GZMB                        0              0.000000               0.00000 #> TSC2                        0              0.000000               0.00000 #>          X22_Y-101..Macrophage X21_Y-101..Macrophage X23_Y-103..Macrophage #> PDK4                  4.311194                     0              1.588185 #> TNFRSF17              0.000000                     0              0.000000 #> ICAM3                 0.000000                     0              0.000000 #> FAP                   0.000000                     0              0.000000 #> GZMB                  0.000000                     0              0.000000 #> TSC2                  0.000000                     0              0.000000 #>          X25_Y-97..Macrophage X27_Y-98..Macrophage X26_Y-98..Macrophage #> PDK4                        0             1.946824             2.400924 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             0.000000             0.000000 #> GZMB                        0             0.000000             0.000000 #> TSC2                        0             0.000000             0.000000 #>          X24_Y-98..Macrophage X25_Y-99..Macrophage X27_Y-99..Macrophage #> PDK4                 4.426577                    0             4.091399 #> TNFRSF17             0.000000                    0             0.000000 #> ICAM3                0.000000                    0             0.000000 #> FAP                  0.000000                    0             0.000000 #> GZMB                 0.000000                    0             0.000000 #> TSC2                 0.000000                    0             0.000000 #>          X24_Y-99..Macrophage X29_Y-100..Macrophage X25_Y-100..Macrophage #> PDK4                 2.622667                     0                     0 #> TNFRSF17             0.000000                     0                     0 #> ICAM3                0.000000                     0                     0 #> FAP                  0.000000                     0                     0 #> GZMB                 0.000000                     0                     0 #> TSC2                 0.000000                     0                     0 #>          X27_Y-100..Macrophage X24_Y-100..Macrophage X30_Y-100..Macrophage #> PDK4                         0              5.167361                     0 #> TNFRSF17                     0              0.000000                     0 #> ICAM3                        0              0.000000                     0 #> FAP                          0              0.000000                     0 #> GZMB                         0              0.000000                     0 #> TSC2                         0              0.000000                     0 #>          X26_Y-101..Macrophage X29_Y-101..Macrophage X27_Y-101..Macrophage #> PDK4                         0              2.124001              2.247095 #> TNFRSF17                     0              0.000000              0.000000 #> ICAM3                        0              0.000000              0.000000 #> FAP                          0              0.000000              0.000000 #> GZMB                         0              2.124001              0.000000 #> TSC2                         0              0.000000              0.000000 #>          X28_Y-102..Macrophage X27_Y-102..Macrophage X25_Y-102..Macrophage #> PDK4                         0                     0                     0 #> TNFRSF17                     0                     0                     0 #> ICAM3                        0                     0                     0 #> FAP                          0                     0                     0 #> GZMB                         0                     0                     0 #> TSC2                         0                     0                     0 #>          X28_Y-103..Macrophage X23_Y-104..Macrophage X28_Y-101..Macrophage #> PDK4                         0              2.382278                     0 #> TNFRSF17                     0              0.000000                     0 #> ICAM3                        0              0.000000                     0 #> FAP                          0              0.000000                     0 #> GZMB                         0              0.000000                     0 #> TSC2                         0              0.000000                     0 #>          X78_Y-103..Macrophage X77_Y-103..Macrophage X76_Y-105..Macrophage #> PDK4                         0                     0                     0 #> TNFRSF17                     0                     0                     0 #> ICAM3                        0                     0                     0 #> FAP                          0                     0                     0 #> GZMB                         0                     0                     0 #> TSC2                         0                     0                     0 #>          X73_Y-106..Macrophage X75_Y-106..Macrophage X74_Y-107..Macrophage #> PDK4                  0.000000                     0             0.0000000 #> TNFRSF17              0.000000                     0             0.0000000 #> ICAM3                 0.000000                     0             0.0000000 #> FAP                   0.000000                     0             0.0000000 #> GZMB                  1.188274                     0             0.9506189 #> TSC2                  0.000000                     0             0.0000000 #>          X73_Y-107..Macrophage X74_Y-105..Macrophage X75_Y-107..Macrophage #> PDK4                  0.000000                     0                     0 #> TNFRSF17              0.000000                     0                     0 #> ICAM3                 0.000000                     0                     0 #> FAP                   0.000000                     0                     0 #> GZMB                  1.584365                     0                     0 #> TSC2                  0.000000                     0                     0 #>          X63_Y-97..Macrophage X62_Y-97..Macrophage X61_Y-98..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X62_Y-98..Macrophage X66_Y-98..Macrophage X64_Y-99..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X61_Y-99..Macrophage X62_Y-99..Macrophage X62_Y-100..Macrophage #> PDK4                        0            0.9697523             1.3171129 #> TNFRSF17                    0            0.0000000             0.0000000 #> ICAM3                       0            0.0000000             0.0000000 #> FAP                         0            0.0000000             0.0000000 #> GZMB                        0            0.0000000             0.7881696 #> TSC2                        0            0.0000000             0.0000000 #>          X64_Y-100..Macrophage X61_Y-100..Macrophage X63_Y-100..Macrophage #> PDK4                  1.576855                     0             0.6757949 #> TNFRSF17              0.000000                     0             0.0000000 #> ICAM3                 0.000000                     0             0.0000000 #> FAP                   0.000000                     0             0.0000000 #> GZMB                  0.000000                     0             0.6551227 #> TSC2                  0.000000                     0             0.0000000 #>          X60_Y-100..Macrophage X62_Y-101..Macrophage X63_Y-101..Macrophage #> PDK4                  0.751234             0.9956445             1.3306047 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             0.0000000             0.0000000 #> GZMB                  0.000000             1.7003808             0.7981848 #> TSC2                  0.000000             0.4215032             0.3688153 #>          X60_Y-101..Macrophage X63_Y-102..Macrophage X61_Y-102..Macrophage #> PDK4                  1.692747              2.737818              1.512170 #> TNFRSF17              0.000000              0.000000              0.000000 #> ICAM3                 0.000000              0.000000              0.000000 #> FAP                   0.000000              0.000000              0.000000 #> GZMB                  0.000000              0.000000              0.000000 #> TSC2                  0.000000              0.000000              0.759852 #>          X60_Y-102..Macrophage X62_Y-102..Macrophage X62_Y-103..Macrophage #> PDK4                   1.98778             0.9526356              1.017697 #> TNFRSF17               0.00000             0.0000000              0.000000 #> ICAM3                  0.00000             0.0000000              0.000000 #> FAP                    0.00000             0.0000000              0.000000 #> GZMB                   0.00000             0.0000000              0.000000 #> TSC2                   0.00000             0.0000000              0.000000 #>          X65_Y-103..Macrophage X64_Y-103..Macrophage X63_Y-103..Macrophage #> PDK4                  1.459591             0.6100838             0.0000000 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             0.0000000             0.0000000 #> GZMB                  0.000000             0.0000000             0.0000000 #> TSC2                  0.000000             0.0000000             0.9373996 #>          X64_Y-104..Macrophage X65_Y-104..Macrophage X65_Y-99..Macrophage #> PDK4                         0             0.6158461                    0 #> TNFRSF17                     0             0.0000000                    0 #> ICAM3                        0             0.0000000                    0 #> FAP                          0             0.0000000                    0 #> GZMB                         0             0.6595507                    0 #> TSC2                         0             0.0000000                    0 #>          X66_Y-101..Macrophage X65_Y-101..Macrophage X61_Y-101..Macrophage #> PDK4                         0                     0             0.7796220 #> TNFRSF17                     0                     0             0.0000000 #> ICAM3                        0                     0             0.0000000 #> FAP                          0                     0             0.0000000 #> GZMB                         0                     0             0.7624308 #> TSC2                         0                     0             0.0000000 #>          X65_Y-102..Macrophage X66_Y-102..Macrophage X66_Y-103..Macrophage #> PDK4                         0                     0              1.459591 #> TNFRSF17                     0                     0              0.000000 #> ICAM3                        0                     0              0.000000 #> FAP                          0                     0              0.000000 #> GZMB                         0                     0              0.000000 #> TSC2                         0                     0              0.000000 #>          X22_Y-104..Macrophage X22_Y-105..Macrophage X23_Y-105..Macrophage #> PDK4                         0                     0               1.50395 #> TNFRSF17                     0                     0               0.00000 #> ICAM3                        0                     0               0.00000 #> FAP                          0                     0               0.00000 #> GZMB                         0                     0               0.00000 #> TSC2                         0                     0               0.00000 #>          X22_Y-106..Macrophage X69_Y-85..Macrophage X71_Y-86..Macrophage #> PDK4                         0             1.171473                    0 #> TNFRSF17                     0             0.000000                    0 #> ICAM3                        0             0.000000                    0 #> FAP                          0             0.000000                    0 #> GZMB                         0             0.000000                    0 #> TSC2                         0             0.000000                    0 #>          X67_Y-86..Macrophage X70_Y-86..Macrophage X73_Y-86..Macrophage #> PDK4                0.0000000                    0             2.327773 #> TNFRSF17            0.0000000                    0             0.000000 #> ICAM3               0.0000000                    0             0.000000 #> FAP                 0.0000000                    0             0.000000 #> GZMB                0.7921824                    0             0.000000 #> TSC2                0.0000000                    0             0.000000 #>          X69_Y-86..Macrophage X68_Y-86..Macrophage X72_Y-87..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X67_Y-88..Macrophage X66_Y-88..Macrophage X73_Y-88..Macrophage #> PDK4                0.9686831             4.645283             1.548428 #> TNFRSF17            0.0000000             0.000000             0.000000 #> ICAM3               0.0000000             0.000000             0.000000 #> FAP                 0.0000000             0.000000             0.000000 #> GZMB                0.0000000             0.000000             0.000000 #> TSC2                1.8911079             0.000000             0.000000 #>          X72_Y-88..Macrophage X68_Y-88..Macrophage X71_Y-88..Macrophage #> PDK4                 2.322641             1.291578                    0 #> TNFRSF17             0.000000             0.000000                    0 #> ICAM3                0.000000             0.000000                    0 #> FAP                  0.000000             0.000000                    0 #> GZMB                 0.000000             0.000000                    0 #> TSC2                 0.000000             0.000000                    0 #>          X68_Y-89..Macrophage X68_Y-90..Macrophage X69_Y-90..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X67_Y-90..Macrophage X72_Y-91..Macrophage X67_Y-91..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X69_Y-87..Macrophage X72_Y-89..Macrophage X71_Y-90..Macrophage #> PDK4                        0                    0             3.951636 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X25_Y-104..Macrophage X29_Y-104..Macrophage X28_Y-105..Macrophage #> PDK4                         0                     0              1.968116 #> TNFRSF17                     0                     0              0.000000 #> ICAM3                        0                     0              0.000000 #> FAP                          0                     0              0.000000 #> GZMB                         0                     0              0.000000 #> TSC2                         0                     0              0.000000 #>          X25_Y-105..Macrophage X24_Y-105..Macrophage X27_Y-105..Macrophage #> PDK4                  1.971146              3.201997             0.6040406 #> TNFRSF17              0.000000              0.000000             0.0000000 #> ICAM3                 0.000000              0.000000             0.0000000 #> FAP                   0.000000              0.000000             0.0000000 #> GZMB                  0.000000              0.000000             0.0000000 #> TSC2                  0.000000              0.000000             0.0000000 #>          X26_Y-105..Macrophage X29_Y-105..Macrophage X24_Y-106..Macrophage #> PDK4                  2.766882              1.441937              2.265001 #> TNFRSF17              0.000000              0.000000              0.000000 #> ICAM3                 0.000000              0.000000              0.000000 #> FAP                   0.000000              0.000000              0.000000 #> GZMB                  0.000000              0.000000              0.000000 #> TSC2                  0.000000              0.000000              0.000000 #>          X27_Y-106..Macrophage X29_Y-106..Macrophage X25_Y-106..Macrophage #> PDK4                         0              1.441937              1.872701 #> TNFRSF17                     0              0.000000              0.000000 #> ICAM3                        0              0.000000              0.000000 #> FAP                          0              0.000000              0.000000 #> GZMB                         0              0.000000              0.000000 #> TSC2                         0              0.000000              0.000000 #>          X26_Y-106..Macrophage X28_Y-106..Macrophage X28_Y-107..Macrophage #> PDK4                         0              1.630514               2.44577 #> TNFRSF17                     0              0.000000               0.00000 #> ICAM3                        0              0.000000               0.00000 #> FAP                          0              0.000000               0.00000 #> GZMB                         0              0.000000               0.00000 #> TSC2                         0              0.000000               0.00000 #>          X25_Y-107..Macrophage X26_Y-107..Macrophage X27_Y-107..Macrophage #> PDK4                  1.442999                     0                     0 #> TNFRSF17              0.000000                     0                     0 #> ICAM3                 0.000000                     0                     0 #> FAP                   0.000000                     0                     0 #> GZMB                  0.000000                     0                     0 #> TSC2                  0.000000                     0                     0 #>          X69_Y-98..Macrophage X71_Y-98..Macrophage X68_Y-99..Macrophage #> PDK4                        0                    0              4.15104 #> TNFRSF17                    0                    0              0.00000 #> ICAM3                       0                    0              0.00000 #> FAP                         0                    0              0.00000 #> GZMB                        0                    0              0.00000 #> TSC2                        0                    0              0.00000 #>          X70_Y-100..Macrophage X72_Y-100..Macrophage X68_Y-100..Macrophage #> PDK4                         0                     0                     0 #> TNFRSF17                     0                     0                     0 #> ICAM3                        0                     0                     0 #> FAP                          0                     0                     0 #> GZMB                         0                     0                     0 #> TSC2                         0                     0                     0 #>          X72_Y-102..Macrophage X71_Y-102..Macrophage X67_Y-98..Macrophage #> PDK4                         0                     0                    0 #> TNFRSF17                     0                     0                    0 #> ICAM3                        0                     0                    0 #> FAP                          0                     0                    0 #> GZMB                         0                     0                    0 #> TSC2                         0                     0                    0 #>          X70_Y-102..Macrophage X72_Y-104..Macrophage X71_Y-104..Macrophage #> PDK4                         0              4.730565              0.000000 #> TNFRSF17                     0              0.000000              0.000000 #> ICAM3                        0              0.000000              0.000000 #> FAP                          0              0.000000              0.000000 #> GZMB                         0              0.000000              1.034704 #> TSC2                         0              0.000000              0.000000 #>          X68_Y-104..Macrophage X70_Y-104..Macrophage X71_Y-105..Macrophage #> PDK4                         0              1.052012             1.7686346 #> TNFRSF17                     0              0.000000             0.0000000 #> ICAM3                        0              0.000000             0.0000000 #> FAP                          0              0.000000             0.0000000 #> GZMB                         0              0.000000             0.8277628 #> TSC2                         0              0.000000             0.0000000 #>          X70_Y-105..Macrophage X68_Y-105..Macrophage X72_Y-105..Macrophage #> PDK4                  2.104024              1.276387                     0 #> TNFRSF17              0.000000              0.000000                     0 #> ICAM3                 0.000000              0.000000                     0 #> FAP                   0.000000              0.000000                     0 #> GZMB                  0.000000              0.000000                     0 #> TSC2                  0.000000              0.000000                     0 #>          X67_Y-105..Macrophage X69_Y-106..Macrophage X71_Y-106..Macrophage #> PDK4                         0              0.000000              1.545042 #> TNFRSF17                     0              0.000000              0.000000 #> ICAM3                        0              0.000000              0.000000 #> FAP                          0              0.000000              0.000000 #> GZMB                         0              1.879895              0.000000 #> TSC2                         0              0.000000              0.000000 #>          X67_Y-106..Macrophage X66_Y-106..Macrophage X70_Y-106..Macrophage #> PDK4                         0                     0              0.000000 #> TNFRSF17                     0                     0              0.000000 #> ICAM3                        0                     0              0.000000 #> FAP                          0                     0              0.000000 #> GZMB                         0                     0              1.879895 #> TSC2                         0                     0              0.000000 #>          X72_Y-106..Macrophage X67_Y-107..Macrophage X71_Y-107..Macrophage #> PDK4                         0             0.7241396              1.519148 #> TNFRSF17                     0             0.0000000              0.000000 #> ICAM3                        0             0.0000000              0.000000 #> FAP                          0             0.0000000              0.000000 #> GZMB                         0             0.0000000              0.000000 #> TSC2                         0             0.0000000              0.000000 #>          X66_Y-107..Macrophage X69_Y-107..Macrophage X68_Y-107..Macrophage #> PDK4                   1.61865                     0             0.8550494 #> TNFRSF17               0.00000                     0             0.0000000 #> ICAM3                  0.00000                     0             0.0000000 #> FAP                    0.00000                     0             0.0000000 #> GZMB                   0.00000                     0             0.8442717 #> TSC2                   0.00000                     0             0.0000000 #>          X67_Y-104..Macrophage X68_Y-106..Macrophage X56_Y-103..Macrophage #> PDK4                         0              1.710099                     0 #> TNFRSF17                     0              0.000000                     0 #> ICAM3                        0              0.000000                     0 #> FAP                          0              0.000000                     0 #> GZMB                         0              0.000000                     0 #> TSC2                         0              0.000000                     0 #>          X58_Y-103..Macrophage X58_Y-104..Macrophage X55_Y-104..Macrophage #> PDK4                         0                     0                     0 #> TNFRSF17                     0                     0                     0 #> ICAM3                        0                     0                     0 #> FAP                          0                     0                     0 #> GZMB                         0                     0                     0 #> TSC2                         0                     0                     0 #>          X54_Y-104..Macrophage X59_Y-105..Macrophage X60_Y-105..Macrophage #> PDK4                 0.0000000             1.3964319             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.0000000             0.0000000 #> GZMB                 0.4247396             0.5849204             0.0000000 #> TSC2                 0.0000000             0.4087870             0.4598853 #>          X57_Y-105..Macrophage X58_Y-105..Macrophage X55_Y-106..Macrophage #> PDK4                 0.9955345                     0                     0 #> TNFRSF17             0.0000000                     0                     0 #> ICAM3                0.0000000                     0                     0 #> FAP                  0.0000000                     0                     0 #> GZMB                 0.0000000                     0                     0 #> TSC2                 0.0000000                     0                     0 #>          X58_Y-106..Macrophage X57_Y-106..Macrophage X56_Y-106..Macrophage #> PDK4                         0             0.5520564                     0 #> TNFRSF17                     0             0.0000000                     0 #> ICAM3                        0             0.0000000                     0 #> FAP                          0             0.0000000                     0 #> GZMB                         0             0.6037002                     0 #> TSC2                         0             0.0000000                     0 #>          X59_Y-106..Macrophage X56_Y-107..Macrophage X55_Y-107..Macrophage #> PDK4                 0.7999609             0.0000000             0.0000000 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.0000000             0.0000000 #> GZMB                 0.0000000             0.3683869             0.7367739 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X57_Y-107..Macrophage X59_Y-104..Macrophage X55_Y-105..Macrophage #> PDK4                 0.0000000             1.5383841                     0 #> TNFRSF17             0.0000000             0.0000000                     0 #> ICAM3                0.0000000             0.0000000                     0 #> FAP                  0.0000000             0.0000000                     0 #> GZMB                 0.5878309             0.6580354                     0 #> TSC2                 0.0000000             0.0000000                     0 #>          X54_Y-105..Macrophage X60_Y-106..Macrophage X61_Y-104..Macrophage #> PDK4                 0.0000000                     0                     0 #> TNFRSF17             0.0000000                     0                     0 #> ICAM3                0.0000000                     0                     0 #> FAP                  0.0000000                     0                     0 #> GZMB                 0.4854166                     0                     0 #> TSC2                 0.0000000                     0                     0 #>          X65_Y-105..Macrophage X64_Y-105..Macrophage X62_Y-105..Macrophage #> PDK4                 0.2701184                     0             0.8622388 #> TNFRSF17             0.0000000                     0             0.0000000 #> ICAM3                0.0000000                     0             0.0000000 #> FAP                  0.0000000                     0             0.0000000 #> GZMB                 1.0664376                     0             0.8579341 #> TSC2                 0.0000000                     0             0.0000000 #>          X61_Y-105..Macrophage X63_Y-105..Macrophage X63_Y-106..Macrophage #> PDK4                         0              1.666585              1.666585 #> TNFRSF17                     0              0.000000              0.000000 #> ICAM3                        0              0.000000              0.000000 #> FAP                          0              0.000000              0.000000 #> GZMB                         0              0.000000              0.000000 #> TSC2                         0              0.000000              0.000000 #>          X62_Y-106..Macrophage X65_Y-106..Macrophage X64_Y-106..Macrophage #> PDK4                  1.077798              0.000000                     0 #> TNFRSF17              0.000000              0.000000                     0 #> ICAM3                 0.000000              0.000000                     0 #> FAP                   0.000000              0.000000                     0 #> GZMB                  1.072418              1.256816                     0 #> TSC2                  0.000000              0.000000                     0 #>          X65_Y-107..Macrophage X62_Y-104..Macrophage X49_Y-103..Macrophage #> PDK4                  0.000000                     0             0.3683447 #> TNFRSF17              0.000000                     0             0.0000000 #> ICAM3                 0.000000                     0             0.0000000 #> FAP                   0.000000                     0             0.0000000 #> GZMB                  1.256816                     0             0.0000000 #> TSC2                  0.000000                     0             0.0000000 #>          X53_Y-105..Macrophage X51_Y-105..Macrophage X50_Y-106..Macrophage #> PDK4                         0             0.0000000                     0 #> TNFRSF17                     0             0.0000000                     0 #> ICAM3                        0             0.0000000                     0 #> FAP                          0             0.0000000                     0 #> GZMB                         0             0.6887931                     0 #> TSC2                         0             0.0000000                     0 #>          X51_Y-106..Macrophage X54_Y-106..Macrophage X49_Y-106..Macrophage #> PDK4                 0.0000000                     0                     0 #> TNFRSF17             0.0000000                     0                     0 #> ICAM3                0.0000000                     0                     0 #> FAP                  0.0000000                     0                     0 #> GZMB                 0.8265518                     0                     0 #> TSC2                 0.0000000                     0                     0 #>          X53_Y-106..Macrophage X52_Y-106..Macrophage X53_Y-107..Macrophage #> PDK4                         0                     0                     0 #> TNFRSF17                     0                     0                     0 #> ICAM3                        0                     0                     0 #> FAP                          0                     0                     0 #> GZMB                         0                     0                     0 #> TSC2                         0                     0                     0 #>          X50_Y-107..Macrophage X48_Y-107..Macrophage X49_Y-104..Macrophage #> PDK4                 0.0000000              1.124369             0.8287755 #> TNFRSF17             0.0000000              0.000000             0.0000000 #> ICAM3                0.0000000              0.000000             0.0000000 #> FAP                  0.0000000              0.000000             0.0000000 #> GZMB                 0.0000000              0.000000             0.0000000 #> TSC2                 0.6579771              0.000000             0.0000000 #>          X53_Y-104..Macrophage X52_Y-105..Macrophage X50_Y-105..Macrophage #> PDK4                         0                     0                     0 #> TNFRSF17                     0                     0                     0 #> ICAM3                        0                     0                     0 #> FAP                          0                     0                     0 #> GZMB                         0                     0                     0 #> TSC2                         0                     0                     0 #>          X51_Y-107..Macrophage X31_Y-104..Macrophage X33_Y-104..Macrophage #> PDK4                         0                     0                     0 #> TNFRSF17                     0                     0                     0 #> ICAM3                        0                     0                     0 #> FAP                          0                     0                     0 #> GZMB                         0                     0                     0 #> TSC2                         0                     0                     0 #>          X32_Y-104..Macrophage X35_Y-105..Macrophage X31_Y-105..Macrophage #> PDK4                 0.9181351              3.725352               1.20144 #> TNFRSF17             0.0000000              0.000000               0.00000 #> ICAM3                0.0000000              0.000000               0.00000 #> FAP                  0.0000000              0.000000               0.00000 #> GZMB                 0.0000000              0.000000               0.00000 #> TSC2                 0.0000000              0.000000               0.00000 #>          X30_Y-105..Macrophage X36_Y-105..Macrophage X33_Y-105..Macrophage #> PDK4                  1.826314              2.413289                     0 #> TNFRSF17              0.000000              0.000000                     0 #> ICAM3                 0.000000              0.000000                     0 #> FAP                   0.000000              0.000000                     0 #> GZMB                  0.000000              0.000000                     0 #> TSC2                  0.000000              0.000000                     0 #>          X32_Y-105..Macrophage X32_Y-106..Macrophage X30_Y-106..Macrophage #> PDK4                 0.9968292              1.329106              2.162906 #> TNFRSF17             0.0000000              0.000000              0.000000 #> ICAM3                0.0000000              0.000000              0.000000 #> FAP                  0.0000000              0.000000              0.000000 #> GZMB                 0.0000000              0.000000              0.000000 #> TSC2                 0.0000000              0.000000              0.000000 #>          X35_Y-106..Macrophage X31_Y-106..Macrophage X34_Y-106..Macrophage #> PDK4                  2.442493                     0              2.080357 #> TNFRSF17              0.000000                     0              0.000000 #> ICAM3                 0.000000                     0              0.000000 #> FAP                   0.000000                     0              0.000000 #> GZMB                  0.000000                     0              0.000000 #> TSC2                  0.000000                     0              0.000000 #>          X32_Y-107..Macrophage X33_Y-107..Macrophage X30_Y-107..Macrophage #> PDK4                  0.000000                     0                     0 #> TNFRSF17              0.000000                     0                     0 #> ICAM3                 0.000000                     0                     0 #> FAP                   0.000000                     0                     0 #> GZMB                  1.313893                     0                     0 #> TSC2                  0.000000                     0                     0 #>          X34_Y-104..Macrophage X33_Y-106..Macrophage X34_Y-107..Macrophage #> PDK4                         0                     0              1.396223 #> TNFRSF17                     0                     0              0.000000 #> ICAM3                        0                     0              0.000000 #> FAP                          0                     0              0.000000 #> GZMB                         0                     0              0.000000 #> TSC2                         0                     0              0.000000 #>          X42_Y-103..Macrophage X43_Y-103..Macrophage X44_Y-103..Macrophage #> PDK4                 0.4584823             0.9530384             0.7624308 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.0000000             0.0000000 #> GZMB                 0.0000000             0.0000000             0.0000000 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X45_Y-104..Macrophage X46_Y-104..Macrophage X47_Y-105..Macrophage #> PDK4                         0             0.0000000               0.00000 #> TNFRSF17                     0             0.0000000               0.00000 #> ICAM3                        0             0.0000000               0.00000 #> FAP                          0             0.0000000               0.00000 #> GZMB                         0             0.9175531               1.37633 #> TSC2                         0             0.0000000               0.00000 #>          X42_Y-105..Macrophage X48_Y-105..Macrophage X42_Y-106..Macrophage #> PDK4                  0.659978                     0             0.6635323 #> TNFRSF17              0.000000                     0             0.0000000 #> ICAM3                 0.000000                     0             0.0000000 #> FAP                   0.000000                     0             0.0000000 #> GZMB                  0.000000                     0             0.0000000 #> TSC2                  0.000000                     0             0.0000000 #>          X46_Y-106..Macrophage X42_Y-107..Macrophage X43_Y-107..Macrophage #> PDK4                 0.7396178                     0                     0 #> TNFRSF17             0.0000000                     0                     0 #> ICAM3                0.0000000                     0                     0 #> FAP                  0.0000000                     0                     0 #> GZMB                 0.0000000                     0                     0 #> TSC2                 0.8853154                     0                     0 #>          X45_Y-107..Macrophage X44_Y-104..Macrophage X47_Y-104..Macrophage #> PDK4                  1.939681                     0              2.508094 #> TNFRSF17              0.000000                     0              0.000000 #> ICAM3                 0.000000                     0              0.000000 #> FAP                   0.000000                     0              0.000000 #> GZMB                  0.000000                     0              0.000000 #> TSC2                  2.213289                     0              0.000000 #>          X48_Y-106..Macrophage X55_Y-98..Macrophage X60_Y-98..Macrophage #> PDK4                         0            0.0000000              0.00000 #> TNFRSF17                     0            0.0000000              0.00000 #> ICAM3                        0            0.0000000              0.00000 #> FAP                          0            0.0000000              0.00000 #> GZMB                         0            0.0000000              1.84332 #> TSC2                         0            0.3768183              0.00000 #>          X58_Y-98..Macrophage X59_Y-98..Macrophage X58_Y-99..Macrophage #> PDK4                        0                    0              1.37558 #> TNFRSF17                    0                    0              0.00000 #> ICAM3                       0                    0              0.00000 #> FAP                         0                    0              0.00000 #> GZMB                        0                    0              0.00000 #> TSC2                        0                    0              0.00000 #>          X60_Y-99..Macrophage X57_Y-99..Macrophage X54_Y-99..Macrophage #> PDK4                1.1717495             2.927429             1.644659 #> TNFRSF17            0.0000000             0.000000             0.000000 #> ICAM3               0.0000000             0.000000             0.000000 #> FAP                 0.0000000             0.000000             0.000000 #> GZMB                0.9216599             0.000000             0.000000 #> TSC2                0.0000000             0.000000             0.000000 #>          X59_Y-100..Macrophage X56_Y-100..Macrophage X58_Y-100..Macrophage #> PDK4                  1.502468                     0               1.84332 #> TNFRSF17              0.000000                     0               0.00000 #> ICAM3                 0.000000                     0               0.00000 #> FAP                   0.000000                     0               0.00000 #> GZMB                  0.000000                     0               0.00000 #> TSC2                  0.000000                     0               0.00000 #>          X59_Y-101..Macrophage X58_Y-101..Macrophage X56_Y-101..Macrophage #> PDK4                  1.662692              3.325383                     0 #> TNFRSF17              0.000000              0.000000                     0 #> ICAM3                 0.000000              0.000000                     0 #> FAP                   0.000000              0.000000                     0 #> GZMB                  0.000000              0.000000                     0 #> TSC2                  1.662692              3.325383                     0 #>          X57_Y-101..Macrophage X58_Y-102..Macrophage X56_Y-102..Macrophage #> PDK4                  4.175964                     0                     0 #> TNFRSF17              0.000000                     0                     0 #> ICAM3                 0.000000                     0                     0 #> FAP                   0.000000                     0                     0 #> GZMB                  0.000000                     0                     0 #> TSC2                  0.000000                     0                     0 #>          X59_Y-102..Macrophage X59_Y-103..Macrophage X60_Y-103..Macrophage #> PDK4                         0             0.7564919              2.209223 #> TNFRSF17                     0             0.0000000              0.000000 #> ICAM3                        0             0.0000000              0.000000 #> FAP                          0             0.0000000              0.000000 #> GZMB                         0             0.0000000              0.000000 #> TSC2                         0             0.0000000              0.000000 #>          X57_Y-103..Macrophage X56_Y-99..Macrophage X55_Y-99..Macrophage #> PDK4                         0                    0                    0 #> TNFRSF17                     0                    0                    0 #> ICAM3                        0                    0                    0 #> FAP                          0                    0                    0 #> GZMB                         0                    0                    0 #> TSC2                         0                    0                    0 #>          X55_Y-100..Macrophage X57_Y-100..Macrophage X39_Y-97..Macrophage #> PDK4                         0               1.84332             1.733741 #> TNFRSF17                     0               0.00000             0.000000 #> ICAM3                        0               0.00000             0.000000 #> FAP                          0               0.00000             0.000000 #> GZMB                         0               0.00000             0.000000 #> TSC2                         0               0.00000             0.000000 #>          X38_Y-98..Macrophage X37_Y-98..Macrophage X40_Y-98..Macrophage #> PDK4                        0             1.082844             1.588185 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             0.000000             0.000000 #> GZMB                        0             0.000000             0.000000 #> TSC2                        0             0.000000             0.000000 #>          X40_Y-99..Macrophage X41_Y-99..Macrophage X39_Y-99..Macrophage #> PDK4                        0                    0             2.399883 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X39_Y-100..Macrophage X37_Y-100..Macrophage X38_Y-100..Macrophage #> PDK4                 0.7999609                     0              1.489428 #> TNFRSF17             0.0000000                     0              0.000000 #> ICAM3                0.0000000                     0              0.000000 #> FAP                  0.0000000                     0              0.000000 #> GZMB                 0.0000000                     0              0.000000 #> TSC2                 0.0000000                     0              0.000000 #>          X40_Y-100..Macrophage X41_Y-100..Macrophage X39_Y-101..Macrophage #> PDK4                         0                     0                     0 #> TNFRSF17                     0                     0                     0 #> ICAM3                        0                     0                     0 #> FAP                          0                     0                     0 #> GZMB                         0                     0                     0 #> TSC2                         0                     0                     0 #>          X37_Y-101..Macrophage X41_Y-101..Macrophage X38_Y-101..Macrophage #> PDK4                         0              5.430541             0.7447139 #> TNFRSF17                     0              0.000000             0.0000000 #> ICAM3                        0              0.000000             0.0000000 #> FAP                          0              0.000000             0.0000000 #> GZMB                         0              0.000000             0.0000000 #> TSC2                         0              0.000000             0.0000000 #>          X41_Y-102..Macrophage X42_Y-102..Macrophage X38_Y-103..Macrophage #> PDK4                 0.9923803              1.051135              2.894775 #> TNFRSF17             0.0000000              0.000000              0.000000 #> ICAM3                0.0000000              0.000000              0.000000 #> FAP                  0.0000000              0.000000              0.000000 #> GZMB                 0.6323682              0.000000              0.000000 #> TSC2                 0.0000000              0.000000              0.000000 #>          X41_Y-103..Macrophage X37_Y-103..Macrophage X40_Y-103..Macrophage #> PDK4                         0                     0                     0 #> TNFRSF17                     0                     0                     0 #> ICAM3                        0                     0                     0 #> FAP                          0                     0                     0 #> GZMB                         0                     0                     0 #> TSC2                         0                     0                     0 #>          X39_Y-103..Macrophage X61_Y-86..Macrophage X60_Y-86..Macrophage #> PDK4                  5.054737            1.7403408            0.7595742 #> TNFRSF17              0.000000            0.0000000            0.0000000 #> ICAM3                 0.000000            0.0000000            0.0000000 #> FAP                   0.000000            0.0000000            0.0000000 #> GZMB                  0.000000            0.4282238            0.0000000 #> TSC2                  0.000000            0.0000000            0.0000000 #>          X62_Y-86..Macrophage X63_Y-86..Macrophage X66_Y-86..Macrophage #> PDK4                 1.067153                    0            1.2435692 #> TNFRSF17             0.000000                    0            0.0000000 #> ICAM3                0.000000                    0            0.0000000 #> FAP                  0.000000                    0            0.0000000 #> GZMB                 0.000000                    0            0.8318796 #> TSC2                 0.000000                    0            0.0000000 #>          X64_Y-86..Macrophage X61_Y-87..Macrophage X62_Y-87..Macrophage #> PDK4                        0             1.424849            0.7438968 #> TNFRSF17                    0             0.000000            0.0000000 #> ICAM3                       0             0.000000            0.0000000 #> FAP                         0             0.000000            0.0000000 #> GZMB                        0             0.000000            0.0000000 #> TSC2                        0             0.000000            0.7839302 #>          X63_Y-87..Macrophage X62_Y-88..Macrophage X61_Y-88..Macrophage #> PDK4                        0            0.7844143                    0 #> TNFRSF17                    0            0.0000000                    0 #> ICAM3                       0            0.0000000                    0 #> FAP                         0            0.0000000                    0 #> GZMB                        0            0.0000000                    0 #> TSC2                        0            1.5678605                    0 #>          X61_Y-89..Macrophage X63_Y-89..Macrophage X64_Y-89..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X62_Y-89..Macrophage X63_Y-90..Macrophage X61_Y-90..Macrophage #> PDK4                        0            0.9451821             1.978732 #> TNFRSF17                    0            0.0000000             0.000000 #> ICAM3                       0            0.0000000             0.000000 #> FAP                         0            0.0000000             0.000000 #> GZMB                        0            0.0000000             1.423642 #> TSC2                        0            0.0000000             0.000000 #>          X62_Y-90..Macrophage X66_Y-90..Macrophage X63_Y-88..Macrophage #> PDK4                 1.454123                    0                    0 #> TNFRSF17             0.000000                    0                    0 #> ICAM3                0.000000                    0                    0 #> FAP                  0.000000                    0                    0 #> GZMB                 0.000000                    0                    0 #> TSC2                 0.000000                    0                    0 #>          X60_Y-90..Macrophage X64_Y-90..Macrophage X63_Y-91..Macrophage #> PDK4                 1.516039                    0            0.9672564 #> TNFRSF17             0.000000                    0            0.0000000 #> ICAM3                0.000000                    0            0.0000000 #> FAP                  0.000000                    0            0.0000000 #> GZMB                 0.000000                    0            0.0000000 #> TSC2                 0.000000                    0            0.0000000 #>          X38_Y-92..Macrophage X39_Y-93..Macrophage X37_Y-93..Macrophage #> PDK4                 0.000000                    0            0.9398992 #> TNFRSF17             0.000000                    0            0.0000000 #> ICAM3                0.000000                    0            0.0000000 #> FAP                  0.000000                    0            0.0000000 #> GZMB                 3.782335                    0            0.0000000 #> TSC2                 0.000000                    0            0.0000000 #>          X36_Y-93..Macrophage X36_Y-94..Macrophage X40_Y-94..Macrophage #> PDK4                 1.778634             1.792318             1.244429 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  0.000000             0.000000             0.000000 #> GZMB                 0.000000             0.000000             0.000000 #> TSC2                 0.000000             0.000000             0.000000 #>          X39_Y-94..Macrophage X39_Y-95..Macrophage X42_Y-95..Macrophage #> PDK4                0.0000000            0.0000000                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.0000000            0.0000000                    0 #> GZMB                0.6697879            0.8372349                    0 #> TSC2                0.0000000            0.0000000                    0 #>          X37_Y-95..Macrophage X41_Y-96..Macrophage X39_Y-96..Macrophage #> PDK4                 4.394449                    0            0.6934963 #> TNFRSF17             0.000000                    0            0.0000000 #> ICAM3                0.000000                    0            0.0000000 #> FAP                  0.000000                    0            0.0000000 #> GZMB                 0.000000                    0            0.0000000 #> TSC2                 0.000000                    0            0.0000000 #>          X41_Y-97..Macrophage X37_Y-97..Macrophage X37_Y-92..Macrophage #> PDK4                 1.612094             1.624265             0.000000 #> TNFRSF17             0.000000             0.000000             0.000000 #> ICAM3                0.000000             0.000000             0.000000 #> FAP                  0.000000             0.000000             0.000000 #> GZMB                 0.000000             0.000000             1.260778 #> TSC2                 0.000000             0.000000             0.000000 #>          X41_Y-94..Macrophage X37_Y-96..Macrophage X41_Y-104..Macrophage #> PDK4                        0             1.364796              1.297643 #> TNFRSF17                    0             0.000000              0.000000 #> ICAM3                       0             0.000000              0.000000 #> FAP                         0             0.000000              0.000000 #> GZMB                        0             1.847129              0.000000 #> TSC2                        0             0.000000              0.000000 #>          X36_Y-104..Macrophage X41_Y-105..Macrophage X40_Y-105..Macrophage #> PDK4                   4.99761              1.605025              1.278432 #> TNFRSF17               0.00000              0.000000              0.000000 #> ICAM3                  0.00000              0.000000              0.000000 #> FAP                    0.00000              0.000000              0.000000 #> GZMB                   0.00000              0.000000              0.000000 #> TSC2                   0.00000              0.000000              0.000000 #>          X41_Y-106..Macrophage X39_Y-106..Macrophage X37_Y-106..Macrophage #> PDK4                 0.8853154                     0              1.594193 #> TNFRSF17             0.0000000                     0              0.000000 #> ICAM3                0.0000000                     0              0.000000 #> FAP                  0.0000000                     0              0.000000 #> GZMB                 0.0000000                     0              0.000000 #> TSC2                 0.0000000                     0              0.000000 #>          X38_Y-106..Macrophage X37_Y-107..Macrophage X38_Y-107..Macrophage #> PDK4                  1.391988              1.992741                     0 #> TNFRSF17              0.000000              0.000000                     0 #> ICAM3                 0.000000              0.000000                     0 #> FAP                   0.000000              0.000000                     0 #> GZMB                  0.000000              0.000000                     0 #> TSC2                  0.000000              0.000000                     0 #>          X40_Y-107..Macrophage X40_Y-106..Macrophage X41_Y-107..Macrophage #> PDK4                         0                     0                     0 #> TNFRSF17                     0                     0                     0 #> ICAM3                        0                     0                     0 #> FAP                          0                     0                     0 #> GZMB                         0                     0                     0 #> TSC2                         0                     0                     0 #>          X53_Y-86..Macrophage X51_Y-86..Macrophage X50_Y-86..Macrophage #> PDK4                        0            0.6157095            0.5119313 #> TNFRSF17                    0            0.0000000            0.0000000 #> ICAM3                       0            0.0000000            0.0000000 #> FAP                         0            0.0000000            0.0000000 #> GZMB                        0            0.0000000            0.0000000 #> TSC2                        0            0.0000000            0.0000000 #>          X51_Y-87..Macrophage X50_Y-87..Macrophage X53_Y-87..Macrophage #> PDK4                0.0000000            0.3412875            1.1317209 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            0.0000000            0.0000000 #> GZMB                0.7088218            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.7598619 #>          X52_Y-87..Macrophage X49_Y-87..Macrophage X50_Y-88..Macrophage #> PDK4                0.9054788            0.8922617                    0 #> TNFRSF17            0.0000000            0.0000000                    0 #> ICAM3               0.0000000            0.0000000                    0 #> FAP                 0.0000000            0.0000000                    0 #> GZMB                0.4510684            0.0000000                    0 #> TSC2                0.3324332            0.9226102                    0 #>          X53_Y-88..Macrophage X49_Y-88..Macrophage X54_Y-88..Macrophage #> PDK4                0.3459063            0.4461309            1.4334452 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            0.0000000            0.0000000 #> GZMB                0.2499922            0.0000000            0.3423367 #> TSC2                0.5392641            0.4613051            0.3643923 #>          X51_Y-88..Macrophage X52_Y-88..Macrophage X53_Y-89..Macrophage #> PDK4                  1.01758            0.8119746             1.137039 #> TNFRSF17              0.00000            0.0000000             0.000000 #> ICAM3                 0.00000            0.0000000             0.000000 #> FAP                   0.00000            0.0000000             0.000000 #> GZMB                  0.00000            0.0000000             0.000000 #> TSC2                  0.00000            0.4063073             0.000000 #>          X54_Y-89..Macrophage X50_Y-89..Macrophage X52_Y-89..Macrophage #> PDK4                2.3964776             1.462272                    0 #> TNFRSF17            0.0000000             0.000000                    0 #> ICAM3               0.0000000             0.000000                    0 #> FAP                 0.0000000             0.000000                    0 #> GZMB                0.3765704             0.000000                    0 #> TSC2                0.0000000             0.000000                    0 #>          X49_Y-89..Macrophage X51_Y-90..Macrophage X52_Y-90..Macrophage #> PDK4                 1.492281               2.0486             1.267846 #> TNFRSF17             0.000000               0.0000             0.000000 #> ICAM3                0.000000               0.0000             0.000000 #> FAP                  0.000000               0.0000             0.000000 #> GZMB                 0.000000               0.0000             0.000000 #> TSC2                 0.000000               0.0000             0.000000 #>          X53_Y-90..Macrophage X54_Y-90..Macrophage X49_Y-91..Macrophage #> PDK4                 1.267846            0.7175272             0.000000 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  0.000000            0.0000000             0.000000 #> GZMB                 0.000000            0.0000000             1.330841 #> TSC2                 0.000000            0.0000000             0.000000 #>          X52_Y-86..Macrophage X54_Y-87..Macrophage X49_Y-90..Macrophage #> PDK4                        0            0.9916916                    0 #> TNFRSF17                    0            0.0000000                    0 #> ICAM3                       0            0.0000000                    0 #> FAP                         0            0.0000000                    0 #> GZMB                        0            0.0000000                    0 #> TSC2                        0            0.0000000                    0 #>          X48_Y-90..Macrophage X52_Y-91..Macrophage X50_Y-91..Macrophage #> PDK4                        0             1.901769             0.000000 #> TNFRSF17                    0             0.000000             0.000000 #> ICAM3                       0             0.000000             0.000000 #> FAP                         0             0.000000             0.000000 #> GZMB                        0             0.000000             3.992524 #> TSC2                        0             0.000000             0.000000 #>          X59_Y-85..Macrophage X56_Y-86..Macrophage X59_Y-86..Macrophage #> PDK4                 1.670264                    0            0.9733472 #> TNFRSF17             0.000000                    0            0.0000000 #> ICAM3                0.000000                    0            0.0000000 #> FAP                  0.000000                    0            0.0000000 #> GZMB                 0.000000                    0            0.0000000 #> TSC2                 0.000000                    0            0.0000000 #>          X58_Y-86..Macrophage X54_Y-86..Macrophage X56_Y-87..Macrophage #> PDK4                0.4992796                    0                    0 #> TNFRSF17            0.0000000                    0                    0 #> ICAM3               0.0000000                    0                    0 #> FAP                 0.0000000                    0                    0 #> GZMB                0.0000000                    0                    0 #> TSC2                0.4907079                    0                    0 #>          X60_Y-87..Macrophage X57_Y-87..Macrophage X58_Y-87..Macrophage #> PDK4                 3.197619                    0             1.472099 #> TNFRSF17             0.000000                    0             0.000000 #> ICAM3                0.000000                    0             0.000000 #> FAP                  0.000000                    0             0.000000 #> GZMB                 0.000000                    0             0.000000 #> TSC2                 0.000000                    0             0.000000 #>          X58_Y-88..Macrophage X59_Y-87..Macrophage X57_Y-88..Macrophage #> PDK4                1.2702814             1.840124            0.7257344 #> TNFRSF17            0.0000000             0.000000            0.0000000 #> ICAM3               0.0000000             0.000000            0.0000000 #> FAP                 0.0000000             0.000000            0.0000000 #> GZMB                0.5046065             0.000000            0.0000000 #> TSC2                0.0000000             0.000000            0.0000000 #>          X55_Y-88..Macrophage X59_Y-88..Macrophage X56_Y-88..Macrophage #> PDK4                        0            0.5649289                    0 #> TNFRSF17                    0            0.0000000                    0 #> ICAM3                       0            0.0000000                    0 #> FAP                         0            0.0000000                    0 #> GZMB                        0            0.0000000                    0 #> TSC2                        0            0.6016900                    0 #>          X58_Y-89..Macrophage X55_Y-89..Macrophage X56_Y-89..Macrophage #> PDK4                1.1355644            0.5043279            0.0000000 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            0.0000000            0.0000000 #> GZMB                0.5619661            0.0000000            0.0000000 #> TSC2                0.0000000            0.0000000            0.4617821 #>          X57_Y-89..Macrophage X59_Y-89..Macrophage X55_Y-90..Macrophage #> PDK4                1.2977878            0.8473933            0.2695304 #> TNFRSF17            0.0000000            0.0000000            0.0000000 #> ICAM3               0.0000000            0.0000000            0.0000000 #> FAP                 0.0000000            0.0000000            0.0000000 #> GZMB                0.3964765            0.0000000            0.3169616 #> TSC2                0.0000000            0.0000000            0.0000000 #>          X58_Y-90..Macrophage X57_Y-90..Macrophage X56_Y-90..Macrophage #> PDK4                1.4039788            1.4211448             0.363856 #> TNFRSF17            0.0000000            0.0000000             0.000000 #> ICAM3               0.0000000            0.0000000             0.000000 #> FAP                 0.0000000            0.0000000             0.000000 #> GZMB                0.2023992            0.2457704             0.000000 #> TSC2                0.0000000            0.0000000             0.000000 #>          X54_Y-85..Macrophage X55_Y-86..Macrophage X59_Y-90..Macrophage #> PDK4                 1.768058                    0             1.846648 #> TNFRSF17             0.000000                    0             0.000000 #> ICAM3                0.000000                    0             0.000000 #> FAP                  0.000000                    0             0.000000 #> GZMB                 0.000000                    0             0.000000 #> TSC2                 0.000000                    0             0.000000 #>          X56_Y-91..Macrophage X55_Y-64..Macrophage X56_Y-65..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X55_Y-65..Macrophage X59_Y-66..Macrophage X57_Y-66..Macrophage #> PDK4                 1.045658                    0                    0 #> TNFRSF17             0.000000                    0                    0 #> ICAM3                0.000000                    0                    0 #> FAP                  0.000000                    0                    0 #> GZMB                 0.000000                    0                    0 #> TSC2                 0.000000                    0                    0 #>          X56_Y-66..Macrophage X58_Y-66..Macrophage X58_Y-67..Macrophage #> PDK4                        0                    0                    0 #> TNFRSF17                    0                    0                    0 #> ICAM3                       0                    0                    0 #> FAP                         0                    0                    0 #> GZMB                        0                    0                    0 #> TSC2                        0                    0                    0 #>          X69_Y-64..Macrophage X72_Y-65..Macrophage X71_Y-65..Macrophage #> PDK4                 3.615404            0.5127672             1.211965 #> TNFRSF17             0.000000            0.0000000             0.000000 #> ICAM3                0.000000            0.0000000             0.000000 #> FAP                  0.000000            0.0000000             0.000000 #> GZMB                 0.000000            0.0000000             0.000000 #> TSC2                 0.000000            0.6347209             0.000000 #>          X70_Y-65..Macrophage X67_Y-65..Macrophage X52_Y-97..Macrophage #> PDK4                        0                    0             3.270194 #> TNFRSF17                    0                    0             0.000000 #> ICAM3                       0                    0             0.000000 #> FAP                         0                    0             0.000000 #> GZMB                        0                    0             0.000000 #> TSC2                        0                    0             0.000000 #>          X50_Y-98..Macrophage X49_Y-98..Macrophage X54_Y-98..Macrophage #> PDK4                        0              1.22262                    0 #> TNFRSF17                    0              0.00000                    0 #> ICAM3                       0              0.00000                    0 #> FAP                         0              0.00000                    0 #> GZMB                        0              0.00000                    0 #> TSC2                        0              0.00000                    0 #>          X52_Y-98..Macrophage X48_Y-99..Macrophage X49_Y-99..Macrophage #> PDK4                 1.635097             2.357126              1.22262 #> TNFRSF17             0.000000             0.000000              0.00000 #> ICAM3                0.000000             0.000000              0.00000 #> FAP                  0.000000             0.000000              0.00000 #> GZMB                 0.000000             1.541691              0.00000 #> TSC2                 0.000000             0.000000              0.00000 #>          X53_Y-99..Macrophage X50_Y-99..Macrophage X51_Y-99..Macrophage #> PDK4                        0            0.6707283                    0 #> TNFRSF17                    0            0.0000000                    0 #> ICAM3                       0            0.0000000                    0 #> FAP                         0            0.0000000                    0 #> GZMB                        0            0.0000000                    0 #> TSC2                        0            0.0000000                    0 #>          X50_Y-100..Macrophage X52_Y-100..Macrophage X54_Y-100..Macrophage #> PDK4                  0.975259                     0              1.766418 #> TNFRSF17              0.000000                     0              0.000000 #> ICAM3                 0.000000                     0              0.000000 #> FAP                   0.000000                     0              0.000000 #> GZMB                  0.000000                     0              0.000000 #> TSC2                  0.000000                     0              0.000000 #>          X49_Y-100..Macrophage X53_Y-100..Macrophage X51_Y-100..Macrophage #> PDK4                  1.201118              2.208022              2.685093 #> TNFRSF17              0.000000              0.000000              0.000000 #> ICAM3                 0.000000              0.000000              0.000000 #> FAP                   0.000000              0.000000              0.000000 #> GZMB                  0.000000              0.000000              0.000000 #> TSC2                  0.000000              0.000000              0.000000 #>          X50_Y-101..Macrophage X51_Y-101..Macrophage X49_Y-101..Macrophage #> PDK4                 0.0000000             0.9130059             0.2668444 #> TNFRSF17             0.0000000             0.0000000             0.0000000 #> ICAM3                0.0000000             0.0000000             0.0000000 #> FAP                  0.0000000             0.0000000             0.0000000 #> GZMB                 0.6883303             0.0000000             0.5617099 #> TSC2                 0.0000000             0.0000000             0.0000000 #>          X52_Y-101..Macrophage X48_Y-101..Macrophage X50_Y-102..Macrophage #> PDK4                         0             0.4574475             0.3578855 #> TNFRSF17                     0             0.0000000             0.0000000 #> ICAM3                        0             0.0000000             0.0000000 #> FAP                          0             0.0000000             0.0000000 #> GZMB                         0             0.0000000             0.0000000 #> TSC2                         0             0.0000000             0.0000000 #>          X52_Y-102..Macrophage X49_Y-102..Macrophage X48_Y-102..Macrophage #> PDK4                  1.538374             0.4902589             0.3922071 #> TNFRSF17              0.000000             0.0000000             0.0000000 #> ICAM3                 0.000000             0.0000000             0.0000000 #> FAP                   0.000000             0.0000000             0.0000000 #> GZMB                  0.000000             0.4566371             0.3653096 #> TSC2                  0.000000             0.0000000             0.0000000 #>          X51_Y-102..Macrophage X50_Y-103..Macrophage X52_Y-103..Macrophage #> PDK4                         0             0.9064803              4.615121 #> TNFRSF17                     0             0.0000000              0.000000 #> ICAM3                        0             0.0000000              0.000000 #> FAP                          0             0.0000000              0.000000 #> GZMB                         0             0.0000000              0.000000 #> TSC2                         0             0.0000000              0.000000 #>          X53_Y-103..Macrophage X45_Y-97..Macrophage X47_Y-98..Macrophage #> PDK4                  1.361877             1.736759                    0 #> TNFRSF17              0.000000             0.000000                    0 #> ICAM3                 0.000000             0.000000                    0 #> FAP                   0.000000             0.000000                    0 #> GZMB                  0.000000             0.000000                    0 #> TSC2                  0.000000             0.000000                    0 #>          X45_Y-98..Macrophage X43_Y-98..Macrophage X46_Y-98..Macrophage #> PDK4                 1.530914                    0             0.000000 #> TNFRSF17             0.000000                    0             0.000000 #> ICAM3                0.000000                    0             0.000000 #> FAP                  0.000000                    0             0.000000 #> GZMB                 0.000000                    0             3.081452 #> TSC2                 0.000000                    0             0.000000 #>          X42_Y-99..Macrophage X44_Y-99..Macrophage X44_Y-100..Macrophage #> PDK4                        0            0.6990857             0.7512323 #> TNFRSF17                    0            0.0000000             0.0000000 #> ICAM3                       0            0.0000000             0.0000000 #> FAP                         0            0.0000000             0.0000000 #> GZMB                        0            0.0000000             0.0000000 #> TSC2                        0            0.0000000             0.0000000 #>          X45_Y-100..Macrophage X43_Y-100..Macrophage X46_Y-100..Macrophage #> PDK4                 0.3866215                     0              1.771166 #> TNFRSF17             0.0000000                     0              0.000000 #> ICAM3                0.0000000                     0              0.000000 #> FAP                  0.0000000                     0              0.000000 #> GZMB                 0.0000000                     0              0.000000 #> TSC2                 0.3866215                     0              0.000000 #>          X43_Y-101..Macrophage X47_Y-101..Macrophage X45_Y-101..Macrophage #> PDK4                         0              0.726275                     0 #> TNFRSF17                     0              0.000000                     0 #> ICAM3                        0              0.000000                     0 #> FAP                          0              0.000000                     0 #> GZMB                         0              0.000000                     0 #> TSC2                         0              0.000000                     0 #>          X42_Y-101..Macrophage X46_Y-101..Macrophage X47_Y-102..Macrophage #> PDK4                   1.81018              0.726275             0.6052292 #> TNFRSF17               0.00000              0.000000             0.0000000 #> ICAM3                  0.00000              0.000000             0.0000000 #> FAP                    0.00000              0.000000             0.0000000 #> GZMB                   0.00000              0.000000             0.0000000 #> TSC2                   0.00000              0.000000             0.0000000 #>          X46_Y-102..Macrophage X44_Y-102..Macrophage X47_Y-103..Macrophage #> PDK4                 0.6052292                     0              2.848167 #> TNFRSF17             0.0000000                     0              0.000000 #> ICAM3                0.0000000                     0              0.000000 #> FAP                  0.0000000                     0              0.000000 #> GZMB                 0.0000000                     0              0.000000 #> TSC2                 0.0000000                     0              0.000000 #>          X28_Y-96..NK X24_Y-96..NK X65_Y-93..NK X61_Y-93..NK X63_Y-91..NK #> PDK4                0     0.000000            0     0.000000     0.000000 #> TNFRSF17            0     0.000000            0     0.000000     0.000000 #> ICAM3               0     4.443047            0     2.940466     4.766567 #> FAP                 0     0.000000            0     0.000000     0.000000 #> GZMB                0     0.000000            0     0.000000     2.569343 #> TSC2                0     0.000000            0     0.000000     0.000000 #>          X63_Y-92..NK X62_Y-93..NK X59_Y-92..NK X60_Y-92..NK X57_Y-93..NK #> PDK4         0.000000            0     0.000000            0            0 #> TNFRSF17     0.000000            0     0.000000            0            0 #> ICAM3        4.968821            0     4.275582            0            0 #> FAP          0.000000            0     0.000000            0            0 #> GZMB         3.884015            0     0.000000            0            0 #> TSC2         0.000000            0     0.000000            0            0 #>          X58_Y-94..NK X59_Y-95..NK X60_Y-93..NK X56_Y-97..NK X77_Y-89..NK #> PDK4                0            0     0.000000      0.00000            0 #> TNFRSF17            0            0     0.000000      0.00000            0 #> ICAM3               0            0     4.933978      4.99761            0 #> FAP                 0            0     0.000000      0.00000            0 #> GZMB                0            0     0.000000      0.00000            0 #> TSC2                0            0     0.000000      0.00000            0 #>          X77_Y-90..NK X40_Y-72..NK X72_Y-75..NK X78_Y-75..NK X75_Y-78..NK #> PDK4         0.000000     0.000000     0.000000     0.000000     0.000000 #> TNFRSF17     0.000000     0.000000     0.000000     0.000000     0.000000 #> ICAM3        0.000000     4.676402     5.375527     0.000000     5.254763 #> FAP          0.000000     0.000000     0.000000     0.000000     0.000000 #> GZMB         2.450162     0.000000     0.000000     5.027264     0.000000 #> TSC2         0.000000     4.676402     0.000000     0.000000     0.000000 #>          X69_Y-75..NK X70_Y-76..NK X68_Y-74..NK X72_Y-74..NK X70_Y-75..NK #> PDK4         0.000000            0            0            0     0.000000 #> TNFRSF17     0.000000            0            0            0     0.000000 #> ICAM3        4.968821            0            0            0     2.815207 #> FAP          0.000000            0            0            0     0.000000 #> GZMB         4.968821            0            0            0     0.000000 #> TSC2         4.968821            0            0            0     0.000000 #>          X70_Y-78..NK X54_Y-79..NK X73_Y-68..NK X52_Y-74..NK X54_Y-78..NK #> PDK4                0     0.000000     0.000000            0     0.000000 #> TNFRSF17            0     0.000000     0.000000            0     0.000000 #> ICAM3               0     2.619282     5.333615            0     2.005977 #> FAP                 0     0.000000     0.000000            0     0.000000 #> GZMB                0     2.521017     4.645283            0     2.016813 #> TSC2                0     0.000000     0.000000            0     0.000000 #>          X48_Y-78..NK X49_Y-78..NK X49_Y-79..NK X48_Y-79..NK X53_Y-75..NK #> PDK4         0.000000     0.000000     0.000000            0            0 #> TNFRSF17     0.000000     0.000000     0.000000            0            0 #> ICAM3        2.264917     0.000000     1.151317            0            0 #> FAP          0.000000     0.000000     0.000000            0            0 #> GZMB         2.317563     1.158781     0.000000            0            0 #> TSC2         0.000000     0.000000     0.000000            0            0 #>          X53_Y-78..NK X43_Y-92..NK X44_Y-94..NK X46_Y-95..NK X44_Y-95..NK #> PDK4         0.000000     0.000000            0            0            0 #> TNFRSF17     0.000000     0.000000            0            0            0 #> ICAM3        2.437103     4.498574            0            0            0 #> FAP          0.000000     0.000000            0            0            0 #> GZMB         0.000000     0.000000            0            0            0 #> TSC2         0.000000     0.000000            0            0            0 #>          X42_Y-96..NK X48_Y-98..NK X45_Y-92..NK X46_Y-94..NK X47_Y-96..NK #> PDK4         0.000000            0            0            0     0.000000 #> TNFRSF17     0.000000            0            0            0     0.000000 #> ICAM3        4.123746            0            0            0     0.000000 #> FAP          0.000000            0            0            0     0.000000 #> GZMB         0.000000            0            0            0     4.538951 #> TSC2         0.000000            0            0            0     0.000000 #>          X22_Y-79..NK X54_Y-64..NK X49_Y-66..NK X51_Y-66..NK X43_Y-77..NK #> PDK4         0.000000            0     0.000000     0.000000     0.000000 #> TNFRSF17     0.000000            0     0.000000     0.000000     0.000000 #> ICAM3        0.000000            0     4.927154     0.000000     4.936263 #> FAP          0.000000            0     0.000000     0.000000     0.000000 #> GZMB         5.375527            0     0.000000     4.348158     0.000000 #> TSC2         0.000000            0     0.000000     0.000000     0.000000 #>          X47_Y-77..NK X47_Y-78..NK X75_Y-80..NK X76_Y-81..NK X77_Y-82..NK #> PDK4         0.000000     0.000000            0     0.000000     0.000000 #> TNFRSF17     0.000000     0.000000            0     0.000000     0.000000 #> ICAM3        2.477368     2.264917            0     4.753095     4.371029 #> FAP          0.000000     0.000000            0     0.000000     0.000000 #> GZMB         0.000000     0.000000            0     0.000000     0.000000 #> TSC2         0.000000     0.000000            0     0.000000     0.000000 #>          X73_Y-84..NK X77_Y-68..NK X74_Y-69..NK X73_Y-70..NK X74_Y-70..NK #> PDK4                0     0.000000     0.000000     0.000000     0.000000 #> TNFRSF17            0     0.000000     0.000000     0.000000     0.000000 #> ICAM3               0     4.635125     2.382278     4.605269     1.535090 #> FAP                 0     0.000000     0.000000     0.000000     0.000000 #> GZMB                0     0.000000     2.928734     5.697193     3.716875 #> TSC2                0     0.000000     0.000000     0.000000     1.661037 #>          X72_Y-72..NK X57_Y-67..NK X59_Y-70..NK X60_Y-68..NK X45_Y-80..NK #> PDK4         0.000000     0.000000     0.000000     0.000000     0.000000 #> TNFRSF17     0.000000     0.000000     0.000000     0.000000     0.000000 #> ICAM3        0.000000     4.296792     0.000000     0.000000     4.355722 #> FAP          0.000000     0.000000     0.000000     0.000000     0.000000 #> GZMB         4.459799     0.000000     3.847411     5.089387     0.000000 #> TSC2         0.000000     0.000000     0.000000     0.000000     4.355722 #>          X43_Y-84..NK X46_Y-81..NK X46_Y-82..NK X49_Y-91..NK X53_Y-91..NK #> PDK4         0.000000            0     0.000000     0.000000            0 #> TNFRSF17     0.000000            0     0.000000     0.000000            0 #> ICAM3        4.811788            0     5.164289     2.979880            0 #> FAP          0.000000            0     0.000000     0.000000            0 #> GZMB         4.811788            0     0.000000     1.525432            0 #> TSC2         0.000000            0     0.000000     0.000000            0 #>          X54_Y-92..NK X72_Y-83..NK X71_Y-79..NK X67_Y-84..NK X68_Y-85..NK #> PDK4         0.000000     0.000000     0.000000            0     0.000000 #> TNFRSF17     0.000000     0.000000     0.000000            0     0.000000 #> ICAM3        4.641464     3.992524     4.753095            0     1.322255 #> FAP          0.000000     0.000000     0.000000            0     0.000000 #> GZMB         0.000000     0.000000     0.000000            0     3.124978 #> TSC2         0.000000     0.000000     0.000000            0     1.439492 #>          X64_Y-65..NK X56_Y-80..NK X54_Y-81..NK X55_Y-81..NK X58_Y-81..NK #> PDK4         0.000000            0     0.000000            0     0.000000 #> TNFRSF17     0.000000            0     0.000000            0     0.000000 #> ICAM3        0.000000            0     1.495159            0     2.421251 #> FAP          0.000000            0     0.000000            0     0.000000 #> GZMB         0.000000            0     1.724324            0     0.000000 #> TSC2         5.012325            0     0.000000            0     0.000000 #>          X58_Y-82..NK X54_Y-82..NK X56_Y-82..NK X62_Y-83..NK X61_Y-84..NK #> PDK4         0.000000     0.000000     0.000000     0.000000     0.000000 #> TNFRSF17     0.000000     0.000000     0.000000     0.000000     0.000000 #> ICAM3        2.536743     5.333615     4.782003     4.878511     2.439255 #> FAP          0.000000     0.000000     0.000000     0.000000     0.000000 #> GZMB         0.000000     4.645283     4.097200     0.000000     0.000000 #> TSC2         0.000000     0.000000     0.000000     0.000000     0.000000 #>          X64_Y-84..NK X63_Y-84..NK X65_Y-84..NK X63_Y-85..NK X45_Y-85..NK #> PDK4         0.000000     0.000000     0.000000     0.000000     0.000000 #> TNFRSF17     0.000000     0.000000     0.000000     0.000000     0.000000 #> ICAM3        0.000000     2.332959     4.787888     2.498805     0.000000 #> FAP          0.000000     0.000000     0.000000     0.000000     0.000000 #> GZMB         4.861401     0.000000     0.000000     0.000000     4.085632 #> TSC2         0.000000     0.000000     0.000000     0.000000     0.000000 #>          X45_Y-86..NK X47_Y-89..NK X48_Y-90..NK X45_Y-90..NK X44_Y-91..NK #> PDK4                0     0.000000            0     0.000000            0 #> TNFRSF17            0     0.000000            0     0.000000            0 #> ICAM3               0     4.848761            0     5.500860            0 #> FAP                 0     0.000000            0     0.000000            0 #> GZMB                0     0.000000            0     0.000000            0 #> TSC2                0     0.000000            0     4.126741            0 #>          X48_Y-89..NK X45_Y-91..NK X50_Y-80..NK X53_Y-81..NK X54_Y-80..NK #> PDK4          0.00000            0     0.000000     0.000000     0.000000 #> TNFRSF17      0.00000            0     0.000000     0.000000     0.000000 #> ICAM3         5.33045            0     1.651578     4.811788     5.147937 #> FAP           0.00000            0     0.000000     0.000000     0.000000 #> GZMB          0.00000            0     1.584365     4.126741     3.111700 #> TSC2          0.00000            0     0.000000     0.000000     0.000000 #>          X52_Y-80..NK X52_Y-84..NK X70_Y-96..NK X74_Y-93..NK X75_Y-95..NK #> PDK4         0.000000     0.000000     0.000000            0     0.000000 #> TNFRSF17     0.000000     0.000000     0.000000            0     0.000000 #> ICAM3        4.741765     5.190573     0.000000            0     2.443589 #> FAP          0.000000     0.000000     0.000000            0     0.000000 #> GZMB         0.000000     0.000000     4.887178            0     2.540702 #> TSC2         0.000000     0.000000     0.000000            0     0.000000 #>          X78_Y-96..NK X76_Y-94..NK X78_Y-95..NK X46_Y-67..NK X46_Y-71..NK #> PDK4                0            0            0     0.000000     0.000000 #> TNFRSF17            0            0            0     0.000000     0.000000 #> ICAM3               0            0            0     3.956653     4.576296 #> FAP                 0            0            0     0.000000     0.000000 #> GZMB                0            0            0     0.000000     0.000000 #> TSC2                0            0            0     0.000000     0.000000 #>          X47_Y-72..NK X74_Y-66..NK X74_Y-65..NK X30_Y-102..NK X33_Y-104..NK #> PDK4         0.000000     0.000000            0      0.000000             0 #> TNFRSF17     0.000000     0.000000            0      0.000000             0 #> ICAM3        4.182296     4.426577            0      5.217575             0 #> FAP          0.000000     0.000000            0      0.000000             0 #> GZMB         4.182296     5.113729            0      0.000000             0 #> TSC2         0.000000     0.000000            0      0.000000             0 #>          X28_Y-101..NK X74_Y-106..NK X64_Y-99..NK X65_Y-101..NK X62_Y-101..NK #> PDK4                 0      0.000000     0.000000      0.000000      0.000000 #> TNFRSF17             0      0.000000     0.000000      0.000000      0.000000 #> ICAM3                0      2.354270     0.000000      2.137791      2.307560 #> FAP                  0      0.000000     0.000000      0.000000      0.000000 #> GZMB                 0      2.302635     4.874205      2.418141      2.411979 #> TSC2                 0      0.000000     0.000000      0.000000      0.000000 #>          X63_Y-100..NK X63_Y-101..NK X66_Y-101..NK X64_Y-103..NK X67_Y-85..NK #> PDK4                 0             0      0.000000             0     0.000000 #> TNFRSF17             0             0      0.000000             0     0.000000 #> ICAM3                0             0      2.137791             0     3.966766 #> FAP                  0             0      0.000000             0     0.000000 #> GZMB                 0             0      2.418141             0     3.966766 #> TSC2                 0             0      0.000000             0     0.000000 #>          X67_Y-87..NK X67_Y-88..NK X69_Y-88..NK X69_Y-85..NK X72_Y-101..NK #> PDK4         0.000000     0.000000     0.000000     0.000000      0.000000 #> TNFRSF17     0.000000     0.000000     0.000000     0.000000      0.000000 #> ICAM3        4.684526     4.830101     2.666807     4.753095      5.863282 #> FAP          0.000000     0.000000     0.000000     0.000000      0.000000 #> GZMB         2.072454     4.144908     2.322641     0.000000      0.000000 #> TSC2         0.000000     0.000000     0.000000     0.000000      0.000000 #>          X67_Y-104..NK X71_Y-105..NK X68_Y-106..NK X66_Y-104..NK X56_Y-99..NK #> PDK4          0.000000      0.000000             0             0     0.000000 #> TNFRSF17      0.000000      0.000000             0             0     0.000000 #> ICAM3         0.000000      2.399883             0             0     2.430701 #> FAP           0.000000      0.000000             0             0     0.000000 #> GZMB          4.363345      0.000000             0             0     0.000000 #> TSC2          0.000000      0.000000             0             0     0.000000 #>          X56_Y-98..NK X55_Y-99..NK X58_Y-99..NK X41_Y-98..NK X42_Y-98..NK #> PDK4                0            0     0.000000     0.000000     0.000000 #> TNFRSF17            0            0     0.000000     0.000000     0.000000 #> ICAM3               0            0     5.254133     4.848761     4.635125 #> FAP                 0            0     0.000000     0.000000     0.000000 #> GZMB                0            0     0.000000     0.000000     0.000000 #> TSC2                0            0     0.000000     0.000000     0.000000 #>          X42_Y-99..NK X41_Y-102..NK X41_Y-103..NK X42_Y-103..NK X62_Y-85..NK #> PDK4         0.000000      0.000000      0.000000      0.000000            0 #> TNFRSF17     0.000000      0.000000      0.000000      0.000000            0 #> ICAM3        5.779448      3.051758      1.525879      0.000000            0 #> FAP          0.000000      0.000000      0.000000      0.000000            0 #> GZMB         0.000000      0.000000      1.158781      2.443589            0 #> TSC2         0.000000      0.000000      0.000000      0.000000            0 #>          X63_Y-86..NK X65_Y-86..NK X66_Y-86..NK X62_Y-90..NK X61_Y-91..NK #> PDK4         0.000000     0.000000            0     0.000000     0.000000 #> TNFRSF17     0.000000     0.000000            0     0.000000     0.000000 #> ICAM3        5.091651     2.651652            0     4.576296     4.355722 #> FAP          0.000000     0.000000            0     0.000000     0.000000 #> GZMB         0.000000     0.000000            0     0.000000     0.000000 #> TSC2         0.000000     0.000000            0     4.576296     0.000000 #>          X64_Y-85..NK X64_Y-89..NK X63_Y-90..NK X64_Y-90..NK X39_Y-94..NK #> PDK4         0.000000            0     0.000000     0.000000     0.000000 #> TNFRSF17     0.000000            0     0.000000     0.000000     0.000000 #> ICAM3        5.376614            0     4.497371     4.625072     4.848761 #> FAP          0.000000            0     0.000000     0.000000     0.000000 #> GZMB         0.000000            0     0.000000     0.000000     0.000000 #> TSC2         0.000000            0     2.288148     0.000000     0.000000 #>          X41_Y-104..NK X40_Y-105..NK X53_Y-88..NK X54_Y-89..NK X48_Y-91..NK #> PDK4          0.000000      0.000000     0.000000     0.000000     0.000000 #> TNFRSF17      0.000000      0.000000     0.000000     0.000000     0.000000 #> ICAM3         2.370883      4.861401     3.606646     3.951636     4.363345 #> FAP           0.000000      0.000000     0.000000     0.000000     0.000000 #> GZMB          2.045700      0.000000     0.000000     0.000000     0.000000 #> TSC2          0.000000      0.000000     0.000000     3.951636     0.000000 #>          X51_Y-88..NK X52_Y-89..NK X54_Y-90..NK X52_Y-91..NK X59_Y-91..NK #> PDK4         0.000000     0.000000            0            0     0.000000 #> TNFRSF17     0.000000     0.000000            0            0     0.000000 #> ICAM3        2.430701     2.495167            0            0     0.000000 #> FAP          0.000000     0.000000            0            0     0.000000 #> GZMB         2.430701     0.000000            0            0     4.906964 #> TSC2         0.000000     0.000000            0            0     0.000000 #>          X58_Y-90..NK X55_Y-65..NK X51_Y-100..NK X52_Y-100..NK X49_Y-101..NK #> PDK4                0            0      0.000000      0.000000             0 #> TNFRSF17            0            0      0.000000      0.000000             0 #> ICAM3               0            0      5.081404      4.538951             0 #> FAP                 0            0      0.000000      0.000000             0 #> GZMB                0            0      5.081404      3.856432             0 #> TSC2                0            0      0.000000      0.000000             0 #>          X51_Y-99..NK X43_Y-98..NK X42_Y-101..NK X24_Y-97..Plasma #> PDK4         0.000000       0.0000             0        0.7659193 #> TNFRSF17     0.000000       0.0000             0        0.0000000 #> ICAM3        2.540702       4.5208             0        3.2833320 #> FAP          0.000000       0.0000             0        0.0000000 #> GZMB         4.506615       0.0000             0        0.0000000 #> TSC2         0.000000       0.0000             0        0.0000000 #>          X25_Y-97..Plasma X62_Y-91..Plasma X61_Y-92..Plasma X61_Y-93..Plasma #> PDK4             0.000000         0.000000         0.000000         0.000000 #> TNFRSF17         0.000000         1.260778         1.457010         0.000000 #> ICAM3            3.543635         3.096538         1.457010         0.000000 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             0.000000         4.815342         3.626032         1.588185 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X64_Y-93..Plasma X60_Y-97..Plasma X64_Y-92..Plasma X63_Y-93..Plasma #> PDK4            0.8970955         0.000000         0.000000         0.000000 #> TNFRSF17        0.8607933         4.451387         4.451387         1.075992 #> ICAM3           1.6896404         0.000000         4.451387         2.112051 #> FAP             0.0000000         0.000000         0.000000         0.000000 #> GZMB            2.9090172         4.451387         4.451387         2.343028 #> TSC2            0.0000000         0.000000         0.000000         0.000000 #>          X58_Y-91..Plasma X57_Y-92..Plasma X60_Y-92..Plasma X60_Y-93..Plasma #> PDK4             0.000000          0.00000         0.000000         5.042432 #> TNFRSF17         4.407790          0.00000         0.000000         0.000000 #> ICAM3            2.470424          4.69771         4.836282         0.000000 #> FAP              0.000000          0.00000         0.000000         0.000000 #> GZMB             5.098250          0.00000         0.000000         5.732345 #> TSC2             0.000000          0.00000         0.000000         0.000000 #>          X56_Y-94..Plasma X57_Y-95..Plasma X59_Y-97..Plasma X60_Y-91..Plasma #> PDK4             0.000000         0.000000         4.468283         0.000000 #> TNFRSF17         0.000000         0.000000         0.000000         5.097434 #> ICAM3            0.000000         0.000000         0.000000         0.000000 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             6.329721         5.768786         6.250441         0.000000 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X57_Y-91..Plasma X55_Y-93..Plasma X57_Y-97..Plasma X73_Y-73..Plasma #> PDK4            0.8048740                0         0.000000         0.000000 #> TNFRSF17        2.6532827                0         0.000000         0.000000 #> ICAM3           2.9907500                0         0.000000         2.905183 #> FAP             0.0000000                0         0.000000         0.000000 #> GZMB            0.8788898                0         5.181734         2.076290 #> TSC2            0.0000000                0         0.000000         0.000000 #>          X73_Y-74..Plasma X75_Y-78..Plasma X61_Y-69..Plasma X62_Y-69..Plasma #> PDK4             0.000000         0.000000                0         0.000000 #> TNFRSF17         2.544693         4.172813                0         1.898395 #> ICAM3            2.595287         4.573129                0         0.000000 #> FAP              0.000000         0.000000                0         0.000000 #> GZMB             2.595287         0.000000                0         0.000000 #> TSC2             0.000000         0.000000                0         0.000000 #>          X62_Y-70..Plasma X63_Y-72..Plasma X64_Y-73..Plasma X65_Y-73..Plasma #> PDK4             0.000000         0.000000         0.000000         0.000000 #> TNFRSF17         3.163992         4.933978         1.987211         1.324807 #> ICAM3            0.000000         0.000000         4.142808         4.229333 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             0.000000         0.000000         0.000000         0.000000 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X66_Y-73..Plasma X65_Y-74..Plasma X66_Y-77..Plasma X65_Y-75..Plasma #> PDK4             0.000000         0.000000                0                0 #> TNFRSF17         0.000000         0.000000                0                0 #> ICAM3            4.402383         4.566825                0                0 #> FAP              0.000000         0.000000                0                0 #> GZMB             0.000000         0.000000                0                0 #> TSC2             0.000000         0.000000                0                0 #>          X72_Y-73..Plasma X72_Y-74..Plasma X72_Y-75..Plasma X70_Y-76..Plasma #> PDK4             0.000000         0.000000         2.302635         2.213289 #> TNFRSF17         1.919237         2.723893         2.166602         2.213289 #> ICAM3            4.735393         4.815469         2.166602         2.556864 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             5.080242         3.237124         2.992018         5.750529 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X71_Y-77..Plasma X71_Y-78..Plasma X70_Y-78..Plasma X71_Y-79..Plasma #> PDK4             0.000000        2.4002148         1.366269         2.067891 #> TNFRSF17         0.000000        0.9757137         0.000000         1.993658 #> ICAM3            2.393944        1.1969721         2.176280         2.335573 #> FAP              0.000000        0.0000000         0.000000         0.000000 #> GZMB             3.083958        5.2610635         4.213001         2.067891 #> TSC2             0.000000        0.0000000         0.000000         0.000000 #>          X68_Y-74..Plasma X71_Y-75..Plasma X71_Y-76..Plasma X69_Y-76..Plasma #> PDK4             0.000000         0.000000         0.000000         4.426577 #> TNFRSF17         4.730565         0.000000         2.357619         4.426577 #> ICAM3            0.000000         0.000000         0.000000         5.113729 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             6.332920         5.687374         2.615437         5.803865 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X54_Y-77..Plasma X54_Y-78..Plasma X54_Y-76..Plasma X55_Y-78..Plasma #> PDK4             0.000000         0.000000         0.000000         0.000000 #> TNFRSF17         2.244912         1.039303         2.244912         0.000000 #> ICAM3            4.562474         3.492219         4.562474         2.528918 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             0.000000         2.746863         0.000000         5.125980 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X73_Y-66..Plasma X73_Y-67..Plasma X72_Y-70..Plasma X52_Y-72..Plasma #> PDK4            2.1964522        1.5116341         0.000000         4.443047 #> TNFRSF17        0.7611375        0.7611375         0.000000         4.443047 #> ICAM3           1.4789108        1.5734930         3.982138         5.130296 #> FAP             0.0000000        0.0000000         0.000000         0.000000 #> GZMB            2.5003687        3.5193911         0.000000         0.000000 #> TSC2            0.0000000        0.0000000         0.000000         0.000000 #>          X52_Y-73..Plasma X51_Y-73..Plasma X53_Y-74..Plasma X53_Y-75..Plasma #> PDK4            0.7405078        0.0000000         1.137039         0.000000 #> TNFRSF17        2.1592989        0.9805178         2.200745         0.000000 #> ICAM3           2.2658942        1.1393614         3.854028         4.787888 #> FAP             0.0000000        0.0000000         0.000000         0.000000 #> GZMB            0.9415068        1.4122602         0.000000         0.000000 #> TSC2            0.0000000        0.0000000         0.000000         0.000000 #>          X53_Y-78..Plasma X48_Y-78..Plasma X49_Y-79..Plasma X53_Y-79..Plasma #> PDK4             0.000000         1.278012         0.000000         1.658029 #> TNFRSF17         2.078606         1.635655         1.917019         1.090095 #> ICAM3            2.421251         1.635655         4.528472         2.838103 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             2.437103         0.000000         0.000000         5.115705 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X54_Y-79..Plasma X51_Y-78..Plasma X43_Y-91..Plasma X44_Y-91..Plasma #> PDK4             1.011567          0.00000         0.000000         1.256611 #> TNFRSF17         0.927025          0.00000         0.000000         1.256611 #> ICAM3            2.762744          6.20011         3.502503         4.866456 #> FAP              0.000000          0.00000         0.000000         0.000000 #> GZMB             5.993564          0.00000         2.161650         1.701849 #> TSC2             0.000000          0.00000         0.000000         0.000000 #>          X47_Y-91..Plasma X45_Y-91..Plasma X44_Y-92..Plasma X42_Y-92..Plasma #> PDK4             3.016933         0.000000         0.000000         0.000000 #> TNFRSF17         0.000000         0.000000         0.000000         3.745314 #> ICAM3            1.823651         3.604595         4.823959         5.517187 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             1.876805         0.000000         0.000000         0.000000 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X45_Y-92..Plasma X46_Y-93..Plasma X45_Y-94..Plasma X44_Y-95..Plasma #> PDK4             0.000000         0.000000         0.000000         0.000000 #> TNFRSF17         0.000000         4.997610         0.000000         2.162906 #> ICAM3            4.696098         3.912415         2.403882         4.505042 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             0.000000         0.000000         2.897830         1.998880 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X45_Y-97..Plasma X44_Y-97..Plasma X47_Y-98..Plasma X46_Y-92..Plasma #> PDK4             0.000000         0.000000         0.000000         2.255925 #> TNFRSF17         4.029781         1.961036         0.000000         0.000000 #> ICAM3            5.116471         2.302635         4.378773         2.170326 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             4.029781         0.000000         0.000000         0.000000 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X46_Y-94..Plasma X46_Y-95..Plasma X23_Y-79..Plasma X47_Y-66..Plasma #> PDK4             0.000000         1.472815         0.000000         0.000000 #> TNFRSF17         2.498805         0.000000         0.000000         1.411500 #> ICAM3            1.956208         0.000000         4.664183         3.561119 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             2.936917         5.930443         0.000000         0.000000 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X52_Y-65..Plasma X51_Y-66..Plasma X51_Y-67..Plasma X36_Y-83..Plasma #> PDK4             0.000000        1.6435318        1.5094846         2.440335 #> TNFRSF17         0.000000        0.9839354        0.9294496         0.000000 #> ICAM3            4.108909        3.6228577        4.5148009         4.765536 #> FAP              0.000000        0.0000000        0.0000000         0.000000 #> GZMB             0.000000        0.0000000        0.0000000         0.000000 #> TSC2             0.000000        0.0000000        0.0000000         0.000000 #>          X36_Y-84..Plasma X37_Y-84..Plasma X41_Y-84..Plasma X39_Y-84..Plasma #> PDK4             1.626890         1.670511         0.000000         3.642174 #> TNFRSF17         1.552997         4.880914         0.000000         0.000000 #> ICAM3            4.899030         4.933213         5.484797         0.000000 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             0.000000         0.000000         0.000000         0.000000 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X47_Y-74..Plasma X47_Y-76..Plasma X46_Y-76..Plasma X42_Y-76..Plasma #> PDK4                    0        0.5555272        0.0000000         1.632668 #> TNFRSF17                0        3.5803102        2.6348229         2.169081 #> ICAM3                   0        1.1933545        0.7259537         0.000000 #> FAP                     0        0.0000000        0.0000000         0.000000 #> GZMB                    0        1.3589303        0.7564919         0.000000 #> TSC2                    0        0.0000000        0.0000000         0.000000 #>          X44_Y-76..Plasma X46_Y-77..Plasma X43_Y-77..Plasma X48_Y-77..Plasma #> PDK4             0.000000         0.000000          0.00000         3.834037 #> TNFRSF17         2.113910         0.000000          4.38658         0.000000 #> ICAM3            2.456824         5.235994          4.38658         0.000000 #> FAP              0.000000         0.000000          0.00000         0.000000 #> GZMB             0.000000         6.149087          0.00000         0.000000 #> TSC2             0.000000         0.000000          0.00000         0.000000 #>          X46_Y-78..Plasma X47_Y-75..Plasma X45_Y-78..Plasma X47_Y-78..Plasma #> PDK4             0.000000         0.000000         2.274077         1.573163 #> TNFRSF17         2.815903         2.340843         4.741066         1.358067 #> ICAM3            1.675755         4.093215         0.000000         1.358067 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             1.644659         0.000000         5.084986         5.242215 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X75_Y-80..Plasma X77_Y-82..Plasma X75_Y-81..Plasma X74_Y-67..Plasma #> PDK4             0.000000         0.000000                0         1.153780 #> TNFRSF17         1.252499         0.000000                0         0.000000 #> ICAM3            3.145313         5.121978                0         0.000000 #> FAP              0.000000         0.000000                0         0.000000 #> GZMB             0.000000         4.035223                0         4.351288 #> TSC2             0.000000         0.000000                0         0.000000 #>          X75_Y-69..Plasma X77_Y-69..Plasma X74_Y-69..Plasma X75_Y-70..Plasma #> PDK4             0.000000                0         0.000000         0.000000 #> TNFRSF17         0.000000                0         2.107297         0.000000 #> ICAM3            4.638294                0         2.450162         0.000000 #> FAP              0.000000                0         0.000000         0.000000 #> GZMB             0.000000                0         2.762726         6.558517 #> TSC2             0.000000                0         0.000000         0.000000 #>          X73_Y-71..Plasma X77_Y-72..Plasma X73_Y-68..Plasma X75_Y-68..Plasma #> PDK4             0.000000         2.174079         0.000000         0.000000 #> TNFRSF17         0.000000         0.000000         0.000000         0.000000 #> ICAM3            4.394449         2.151983         4.676402         4.638294 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             5.484797         3.208110         4.676402         0.000000 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X74_Y-70..Plasma X57_Y-67..Plasma X42_Y-79..Plasma X46_Y-79..Plasma #> PDK4             0.000000         0.000000                0         0.000000 #> TNFRSF17         2.107297         4.736149                0         0.000000 #> ICAM3            4.706087         5.138686                0         1.675755 #> FAP              0.000000         0.000000                0         0.000000 #> GZMB             2.599746         0.000000                0         1.651578 #> TSC2             0.000000         0.000000                0         0.000000 #>          X46_Y-80..Plasma X44_Y-81..Plasma X46_Y-81..Plasma X44_Y-82..Plasma #> PDK4             0.000000        0.3961891         0.000000         0.000000 #> TNFRSF17         0.000000        1.8576300         0.000000         1.978598 #> ICAM3            2.801558        3.8779574         4.958234         3.117699 #> FAP              0.000000        0.0000000         0.000000         0.000000 #> GZMB             2.477368        1.0614453         0.000000         1.161252 #> TSC2             0.000000        0.0000000         0.000000         0.000000 #>          X43_Y-82..Plasma X46_Y-82..Plasma X43_Y-83..Plasma X44_Y-83..Plasma #> PDK4            0.2973873         0.000000        0.5832398         0.000000 #> TNFRSF17        2.5923189         0.000000        2.4724216         1.893269 #> ICAM3           2.8830524         2.327773        3.5269782         2.234142 #> FAP             0.0000000         0.000000        0.0000000         0.000000 #> GZMB            0.6543168         0.000000        0.6992725         0.000000 #> TSC2            0.0000000         0.000000        0.0000000         0.000000 #>          X45_Y-83..Plasma X43_Y-84..Plasma X42_Y-84..Plasma X44_Y-84..Plasma #> PDK4                    0        0.0000000         0.000000         0.000000 #> TNFRSF17                0        0.8289816         1.036227         1.893269 #> ICAM3                   0        3.9481009         2.482558         4.732947 #> FAP                     0        0.0000000         0.000000         0.000000 #> GZMB                    0        2.2768812         2.544201         2.843687 #> TSC2                    0        0.0000000         0.000000         0.000000 #>          X51_Y-91..Plasma X53_Y-91..Plasma X54_Y-92..Plasma X72_Y-81..Plasma #> PDK4             0.000000         0.000000         0.000000         0.000000 #> TNFRSF17         0.000000         5.178805         2.590867         2.283413 #> ICAM3            4.513161         0.000000         0.000000         2.283413 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             0.000000         0.000000         2.873900         2.972648 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X71_Y-83..Plasma X70_Y-84..Plasma X70_Y-85..Plasma X68_Y-84..Plasma #> PDK4             0.000000         0.000000         0.000000         0.000000 #> TNFRSF17         0.000000         0.000000         0.000000         0.000000 #> ICAM3            4.091399         2.791581         4.248003         0.000000 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             4.091399         3.466558         5.623519         6.007351 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X50_Y-67..Plasma X50_Y-68..Plasma X52_Y-67..Plasma X50_Y-69..Plasma #> PDK4            0.6432827        0.0000000         3.931826        0.0000000 #> TNFRSF17        1.1250500        1.6869649         0.000000        1.8601075 #> ICAM3           4.7758792        3.6418106         0.000000        2.0625385 #> FAP             0.0000000        0.0000000         0.000000        0.0000000 #> GZMB            0.0000000        0.4829716         0.000000        0.8351343 #> TSC2            0.0000000        0.0000000         0.000000        0.0000000 #>          X51_Y-69..Plasma X49_Y-69..Plasma X49_Y-70..Plasma X50_Y-70..Plasma #> PDK4                    0        0.6662932        0.7995518         0.000000 #> TNFRSF17                0        2.4005132        1.9495066         0.000000 #> ICAM3                   0        3.2122588        2.9236013         1.432264 #> FAP                     0        0.0000000        0.0000000         0.000000 #> GZMB                    0        1.9326653        2.3191984         3.380911 #> TSC2                    0        0.0000000        0.0000000         0.000000 #>          X48_Y-71..Plasma X54_Y-80..Plasma X56_Y-80..Plasma X55_Y-80..Plasma #> PDK4             0.000000        0.0000000         0.000000        0.6725372 #> TNFRSF17         0.000000        0.0000000         0.000000        0.8711236 #> ICAM3            3.186339        0.8211924         6.021605        2.4746974 #> FAP              0.000000        0.0000000         0.000000        0.0000000 #> GZMB             0.000000        4.8457183         0.000000        1.0202493 #> TSC2             0.000000        0.0000000         0.000000        0.0000000 #>          X57_Y-80..Plasma X55_Y-81..Plasma X57_Y-81..Plasma X58_Y-81..Plasma #> PDK4             0.000000                0         0.000000         0.000000 #> TNFRSF17         0.000000                0         0.000000         0.000000 #> ICAM3            6.021605                0         4.459799         2.229899 #> FAP              0.000000                0         0.000000         0.000000 #> GZMB             0.000000                0         0.000000         0.000000 #> TSC2             0.000000                0         0.000000         0.000000 #>          X60_Y-81..Plasma X56_Y-82..Plasma X54_Y-83..Plasma X62_Y-84..Plasma #> PDK4              2.19329         0.000000                0         0.000000 #> TNFRSF17          0.00000         0.000000                0         0.000000 #> ICAM3             2.19329         5.155681                0         5.121978 #> FAP               0.00000         0.000000                0         0.000000 #> GZMB              0.00000         6.537641                0         4.434777 #> TSC2              0.00000         0.000000                0         0.000000 #>          X66_Y-84..Plasma X63_Y-85..Plasma X64_Y-84..Plasma X35_Y-97..Plasma #> PDK4             0.000000         1.748445         0.000000         0.000000 #> TNFRSF17         0.000000         1.457010         0.000000         3.411989 #> ICAM3            0.000000         3.378865         4.538951         4.994693 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             4.758809         0.000000         0.000000         0.000000 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X35_Y-93..Plasma X44_Y-86..Plasma X46_Y-88..Plasma X47_Y-88..Plasma #> PDK4             0.000000                0         4.378773         0.000000 #> TNFRSF17         0.000000                0         0.000000         3.059035 #> ICAM3            0.000000                0         4.378773         4.692837 #> FAP              0.000000                0         0.000000         0.000000 #> GZMB             5.408168                0         0.000000         0.000000 #> TSC2             0.000000                0         0.000000         0.000000 #>          X47_Y-89..Plasma X46_Y-89..Plasma X45_Y-89..Plasma X48_Y-90..Plasma #> PDK4            1.0255737        0.6427387         0.000000         0.000000 #> TNFRSF17        1.0098663        0.5617318         0.000000         1.930487 #> ICAM3           4.2172420        4.7234613         3.585953         2.155597 #> FAP             0.0000000        0.0000000         0.000000         0.000000 #> GZMB            0.6125405        0.8167207         4.665919         0.000000 #> TSC2            0.0000000        0.0000000         0.000000         0.000000 #>          X42_Y-90..Plasma X42_Y-91..Plasma X45_Y-87..Plasma X46_Y-91..Plasma #> PDK4             4.623797         0.000000         0.000000         2.255925 #> TNFRSF17         0.000000         0.000000         0.000000         0.000000 #> ICAM3            0.000000         0.000000         0.000000         0.000000 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             2.396905         6.555007         6.112466         0.000000 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X50_Y-79..Plasma X52_Y-79..Plasma X48_Y-79..Plasma X51_Y-79..Plasma #> PDK4             1.350579         3.976987         1.167058         0.000000 #> TNFRSF17         3.125048         0.000000         2.802712         1.064682 #> ICAM3            3.636566         3.976987         2.802712         2.792613 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             0.000000         6.357697         0.000000         0.000000 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X51_Y-80..Plasma X53_Y-80..Plasma X52_Y-80..Plasma X53_Y-81..Plasma #> PDK4              0.00000         1.030190                0         0.000000 #> TNFRSF17          0.00000         0.000000                0         1.363800 #> ICAM3             2.82609         1.030190                0         1.592051 #> FAP               0.00000         0.000000                0         0.000000 #> GZMB              0.00000         3.004239                0         0.000000 #> TSC2              0.00000         0.000000                0         0.000000 #>          X53_Y-82..Plasma X51_Y-82..Plasma X51_Y-83..Plasma X52_Y-83..Plasma #> PDK4             1.475526         1.661401        0.9105434        0.9105434 #> TNFRSF17         1.363800         0.000000        2.2128223        3.4188119 #> ICAM3            3.431114         1.661401        3.2933564        4.7726564 #> FAP              0.000000         0.000000        0.0000000        0.0000000 #> GZMB             0.000000         0.000000        1.3913437        1.3913437 #> TSC2             0.000000         0.000000        0.0000000        0.0000000 #>          X51_Y-84..Plasma X52_Y-84..Plasma X52_Y-85..Plasma X50_Y-83..Plasma #> PDK4             0.000000         0.000000        0.5078645         0.000000 #> TNFRSF17         1.864656         1.607986        1.8438383         0.000000 #> ICAM3            4.666213         3.840105        3.6759196         2.586486 #> FAP              0.000000         0.000000        0.0000000         0.000000 #> GZMB             0.000000         0.000000        0.6580076         0.000000 #> TSC2             0.000000         0.000000        0.0000000         0.000000 #>          X69_Y-92..Plasma X77_Y-93..Plasma X77_Y-96..Plasma X74_Y-95..Plasma #> PDK4             0.000000         0.000000         0.000000         0.000000 #> TNFRSF17         0.000000         0.000000         4.525306         4.557445 #> ICAM3            0.000000         4.175964         4.927154         0.000000 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             6.726633         6.241874         0.000000         5.649041 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X48_Y-69..Plasma X46_Y-68..Plasma X48_Y-70..Plasma X47_Y-71..Plasma #> PDK4             0.000000                0                0         0.000000 #> TNFRSF17         0.000000                0                0         0.000000 #> ICAM3            4.832157                0                0         2.255925 #> FAP              0.000000                0                0         0.000000 #> GZMB             3.749358                0                0         0.000000 #> TSC2             0.000000                0                0         0.000000 #>          X47_Y-72..Plasma X73_Y-65..Plasma X34_Y-90..Plasma X35_Y-90..Plasma #> PDK4             0.000000         0.000000         0.000000         0.000000 #> TNFRSF17         5.658486         2.069407         0.000000         0.000000 #> ICAM3            0.000000         2.069407         3.786538         0.000000 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             0.000000         0.000000         4.869919         6.775366 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X35_Y-91..Plasma X41_Y-89..Plasma X39_Y-91..Plasma X30_Y-101..Plasma #> PDK4             0.000000         0.000000                0          5.057837 #> TNFRSF17         0.000000         1.692026                0          0.000000 #> ICAM3            2.292929         0.000000                0          0.000000 #> FAP              0.000000         0.000000                0          0.000000 #> GZMB             0.000000         0.000000                0          0.000000 #> TSC2             0.000000         0.000000                0          0.000000 #>          X33_Y-103..Plasma X32_Y-103..Plasma X27_Y-101..Plasma #> PDK4              0.000000          0.000000           0.00000 #> TNFRSF17          1.141706          0.000000           0.00000 #> ICAM3             0.000000          0.000000           2.73059 #> FAP               0.000000          0.000000           0.00000 #> GZMB              3.257506          4.343342           0.00000 #> TSC2              0.000000          0.000000           0.00000 #>          X27_Y-102..Plasma X29_Y-102..Plasma X74_Y-105..Plasma #> PDK4               0.00000          0.000000          0.000000 #> TNFRSF17           0.00000          3.620698          0.000000 #> ICAM3              2.73059          4.701306          0.000000 #> FAP                0.00000          0.000000          0.000000 #> GZMB               0.00000          4.701306          6.621406 #> TSC2               0.00000          0.000000          0.000000 #>          X74_Y-106..Plasma X61_Y-99..Plasma X61_Y-100..Plasma X63_Y-101..Plasma #> PDK4              0.000000          0.00000          4.836282          0.000000 #> TNFRSF17          4.730565          0.00000          0.000000          0.000000 #> ICAM3             0.000000          0.00000          4.836282          0.000000 #> FAP               0.000000          0.00000          0.000000          0.000000 #> GZMB              5.419291          6.15001          6.908755          5.832549 #> TSC2              0.000000          0.00000          0.000000          0.000000 #>          X66_Y-101..Plasma X62_Y-102..Plasma X60_Y-104..Plasma X67_Y-86..Plasma #> PDK4              0.000000          0.000000          0.000000         0.000000 #> TNFRSF17          0.000000          0.000000          1.383680         0.000000 #> ICAM3             0.000000          4.676402          2.822824         0.000000 #> FAP               0.000000          0.000000          0.000000         0.000000 #> GZMB              5.012325          6.460370          0.000000         6.121496 #> TSC2              0.000000          0.000000          0.000000         0.000000 #>          X69_Y-86..Plasma X68_Y-88..Plasma X69_Y-87..Plasma X25_Y-105..Plasma #> PDK4             0.000000         0.000000         0.000000          1.535090 #> TNFRSF17         0.000000         0.000000         0.000000          0.000000 #> ICAM3            4.615121         0.000000         2.307560          2.930779 #> FAP              0.000000         0.000000         0.000000          0.000000 #> GZMB             0.000000         5.408168         2.829243          0.000000 #> TSC2             0.000000         0.000000         0.000000          0.000000 #>          X25_Y-106..Plasma X26_Y-106..Plasma X26_Y-107..Plasma #> PDK4             0.7002347          0.000000          0.000000 #> TNFRSF17         1.3393087          1.840627          2.010825 #> ICAM3            2.7151079          3.475919          4.085975 #> FAP              0.0000000          0.000000          0.000000 #> GZMB             1.6419427          1.282852          1.110574 #> TSC2             0.0000000          0.000000          0.000000 #>          X69_Y-102..Plasma X71_Y-104..Plasma X68_Y-105..Plasma #> PDK4                 0.000          0.000000          4.645283 #> TNFRSF17             0.000          4.018989          0.000000 #> ICAM3                0.000          0.000000          0.000000 #> FAP                  0.000          0.000000          0.000000 #> GZMB                 6.609          5.391713          0.000000 #> TSC2                 0.000          0.000000          0.000000 #>          X70_Y-105..Plasma X67_Y-106..Plasma X71_Y-106..Plasma #> PDK4              0.000000          0.000000          0.000000 #> TNFRSF17          0.000000          0.000000          0.000000 #> ICAM3             0.000000          0.000000          0.000000 #> FAP               0.000000          0.000000          0.000000 #> GZMB              5.908008          6.345822          6.587051 #> TSC2              0.000000          0.000000          0.000000 #>          X68_Y-107..Plasma X68_Y-106..Plasma X58_Y-104..Plasma #> PDK4              0.000000          0.000000          1.787886 #> TNFRSF17          0.000000          0.000000          1.914810 #> ICAM3             1.114950          0.000000          4.043811 #> FAP               0.000000          0.000000          0.000000 #> GZMB              4.230188          3.422141          0.000000 #> TSC2              0.000000          0.000000          0.000000 #>          X56_Y-105..Plasma X57_Y-105..Plasma X64_Y-104..Plasma #> PDK4              0.000000          0.000000          0.000000 #> TNFRSF17          0.000000          0.000000          0.000000 #> ICAM3             5.357848          0.000000          2.322641 #> FAP               0.000000          0.000000          0.000000 #> GZMB              0.000000          3.912415          2.917272 #> TSC2              0.000000          0.000000          0.000000 #>          X62_Y-105..Plasma X53_Y-106..Plasma X51_Y-106..Plasma #> PDK4              0.000000          0.000000          0.000000 #> TNFRSF17          0.000000          1.946078          0.000000 #> ICAM3             4.018989          1.777054          3.559047 #> FAP               0.000000          0.000000          0.000000 #> GZMB              0.000000          0.000000          0.000000 #> TSC2              0.000000          0.000000          0.000000 #>          X53_Y-107..Plasma X51_Y-107..Plasma X34_Y-104..Plasma #> PDK4              0.000000           0.00000          0.000000 #> TNFRSF17          3.501174           2.14130          4.900324 #> ICAM3             3.501174           4.37481          0.000000 #> FAP               0.000000           0.00000          0.000000 #> GZMB              0.000000           0.00000          0.000000 #> TSC2              0.000000           0.00000          0.000000 #>          X33_Y-104..Plasma X35_Y-107..Plasma X57_Y-98..Plasma X60_Y-100..Plasma #> PDK4              0.000000          0.000000         0.000000          2.205190 #> TNFRSF17          2.366787          0.000000         2.201191          0.000000 #> ICAM3             0.000000          3.786538         2.513632          0.000000 #> FAP               0.000000          0.000000         0.000000          0.000000 #> GZMB              1.238684          0.000000         3.315721          6.339624 #> TSC2              0.000000          0.000000         0.000000          0.000000 #>          X56_Y-103..Plasma X55_Y-103..Plasma X58_Y-99..Plasma X56_Y-99..Plasma #> PDK4              0.000000          0.000000         0.000000         4.848761 #> TNFRSF17          0.000000          1.685195         0.000000         0.000000 #> ICAM3             2.317563          0.000000         0.000000         5.537982 #> FAP               0.000000          0.000000         0.000000         0.000000 #> GZMB              0.000000          0.000000         6.892242         6.921321 #> TSC2              0.000000          0.000000         0.000000         0.000000 #>          X59_Y-103..Plasma X41_Y-98..Plasma X41_Y-99..Plasma X41_Y-100..Plasma #> PDK4              1.787886                0          0.00000          0.000000 #> TNFRSF17          0.000000                0          0.00000          0.000000 #> ICAM3             1.787886                0          2.73059          2.730590 #> FAP               0.000000                0          0.00000          0.000000 #> GZMB              0.000000                0          0.00000          2.829243 #> TSC2              0.000000                0          0.00000          0.000000 #>          X42_Y-100..Plasma X38_Y-100..Plasma X42_Y-101..Plasma #> PDK4              0.000000          4.434777          0.000000 #> TNFRSF17          2.665100          0.000000          0.000000 #> ICAM3             2.665100          4.434777          0.000000 #> FAP               0.000000          0.000000          0.000000 #> GZMB              2.829243          0.000000          5.658486 #> TSC2              0.000000          0.000000          0.000000 #>          X41_Y-102..Plasma X61_Y-86..Plasma X64_Y-86..Plasma X62_Y-87..Plasma #> PDK4              0.000000         0.000000         0.000000         0.000000 #> TNFRSF17          0.000000         0.000000         4.502979         0.000000 #> ICAM3             5.492796         0.000000         4.502979         1.998880 #> FAP               0.000000         0.000000         0.000000         0.000000 #> GZMB              5.492796         5.106143         5.880932         2.746398 #> TSC2              0.000000         0.000000         0.000000         0.000000 #>          X62_Y-88..Plasma X62_Y-90..Plasma X63_Y-91..Plasma X62_Y-86..Plasma #> PDK4             4.163422         0.000000         0.000000         0.000000 #> TNFRSF17         0.000000         0.000000         1.451907         0.000000 #> ICAM3            0.000000         0.000000         3.186568         0.000000 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             5.537982         5.589742         3.367279         5.492796 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X64_Y-91..Plasma X36_Y-91..Plasma X38_Y-94..Plasma X40_Y-94..Plasma #> PDK4             0.000000         0.000000         0.000000         0.000000 #> TNFRSF17         2.177861         0.000000         4.743091         2.888634 #> ICAM3            2.177861         4.585859         4.854128         1.545042 #> FAP              0.000000         0.000000         0.000000         0.000000 #> GZMB             3.133900         0.000000         0.000000         0.000000 #> TSC2             0.000000         0.000000         0.000000         0.000000 #>          X41_Y-96..Plasma X41_Y-94..Plasma X40_Y-105..Plasma X37_Y-106..Plasma #> PDK4             0.000000         0.000000          4.741765          0.000000 #> TNFRSF17         4.472554         4.836282          0.000000          0.000000 #> ICAM3            3.790760         0.000000          0.000000          5.007396 #> FAP              0.000000         0.000000          0.000000          0.000000 #> GZMB             0.000000         0.000000          6.813544          0.000000 #> TSC2             0.000000         0.000000          0.000000          0.000000 #>          X41_Y-107..Plasma X53_Y-86..Plasma X52_Y-86..Plasma X52_Y-87..Plasma #> PDK4              0.000000         0.422140        0.4746413         0.000000 #> TNFRSF17          0.000000         1.316659        1.8979018         0.000000 #> ICAM3             0.000000         3.116949        3.4622854         1.033435 #> FAP               0.000000         0.000000        0.0000000         0.000000 #> GZMB              5.758237         0.000000        0.5757567         0.000000 #> TSC2              0.000000         0.000000        0.0000000         0.000000 #>          X50_Y-87..Plasma X51_Y-87..Plasma X53_Y-87..Plasma X52_Y-88..Plasma #> PDK4             0.000000        0.0000000         0.000000        0.0000000 #> TNFRSF17         0.000000        0.4603567         1.569513        1.9752342 #> ICAM3            4.648065        2.4789001         3.092138        4.2095895 #> FAP              0.000000        0.0000000         0.000000        0.0000000 #> GZMB             1.092757        0.0000000         0.000000        0.4866193 #> TSC2             0.000000        0.0000000         0.000000        0.0000000 #>          X48_Y-88..Plasma X52_Y-89..Plasma X53_Y-89..Plasma X48_Y-89..Plasma #> PDK4             2.193290         0.000000        0.0000000         0.000000 #> TNFRSF17         0.000000         0.000000        0.9540675         2.354270 #> ICAM3            4.707864         1.079619        3.0704809         5.137839 #> FAP              0.000000         0.000000        0.0000000         0.000000 #> GZMB             1.497249         1.249402        0.0000000         0.000000 #> TSC2             0.000000         0.000000        0.0000000         0.000000 #>          X49_Y-89..Plasma X54_Y-89..Plasma X50_Y-89..Plasma X49_Y-90..Plasma #> PDK4             0.000000                0         0.000000         1.516052 #> TNFRSF17         3.161513                0         0.000000         4.056811 #> ICAM3            3.398095                0         4.653479         3.317274 #> FAP              0.000000                0         0.000000         0.000000 #> GZMB             0.000000                0         2.536743         0.000000 #> TSC2             0.000000                0         0.000000         0.000000 #>          X51_Y-90..Plasma X52_Y-90..Plasma X50_Y-90..Plasma X54_Y-90..Plasma #> PDK4             0.000000         0.000000        0.9096309        0.6818316 #> TNFRSF17         0.000000         0.000000        1.9340265        3.8386995 #> ICAM3            4.333204         2.456824        4.8560101        3.8020082 #> FAP              0.000000         0.000000        0.0000000        0.0000000 #> GZMB             0.000000         3.005025        1.0146972        0.0000000 #> TSC2             0.000000         0.000000        0.0000000        0.0000000 #>          X49_Y-91..Plasma X53_Y-85..Plasma X51_Y-86..Plasma X49_Y-88..Plasma #> PDK4             0.000000        0.0000000          0.00000         2.193290 #> TNFRSF17         0.000000        2.1473219          5.27712         0.000000 #> ICAM3            4.692024        2.9920727          5.27712         4.526249 #> FAP              0.000000        0.0000000          0.00000         0.000000 #> GZMB             0.000000        0.5454182          0.00000         0.000000 #> TSC2             0.000000        0.0000000          0.00000         0.000000 #>          X59_Y-89..Plasma X55_Y-89..Plasma X56_Y-90..Plasma X55_Y-90..Plasma #> PDK4                    0         0.000000         1.184146         1.160266 #> TNFRSF17                0         3.790760         2.722520         3.136257 #> ICAM3                   0         5.159975         4.472253         3.894207 #> FAP                     0         0.000000         0.000000         0.000000 #> GZMB                    0         0.000000         0.000000         0.000000 #> TSC2                    0         0.000000         0.000000         0.000000 #>          X57_Y-90..Plasma X55_Y-91..Plasma X56_Y-66..Plasma X73_Y-64..Plasma #> PDK4             1.006093        0.6818316         2.189387         0.000000 #> TNFRSF17         1.098612        3.0530212         0.000000         2.069407 #> ICAM3            1.177135        3.9625613         2.189387         2.069407 #> FAP              0.000000        0.0000000         0.000000         0.000000 #> GZMB             2.212508        0.0000000         0.000000         0.000000 #> TSC2             0.000000        0.0000000         0.000000         0.000000 #>          X71_Y-65..Plasma X48_Y-98..Plasma X53_Y-99..Plasma X48_Y-100..Plasma #> PDK4             4.340652         0.000000         0.000000          0.000000 #> TNFRSF17         4.340652         3.992524         4.282601          1.346841 #> ICAM3            0.000000         5.482145         5.371966          4.441842 #> FAP              0.000000         0.000000         0.000000          0.000000 #> GZMB             0.000000         0.000000         0.000000          1.473550 #> TSC2             0.000000         0.000000         0.000000          0.000000 #>          X48_Y-101..Plasma X49_Y-101..Plasma X54_Y-102..Plasma #> PDK4              0.000000          0.000000          0.000000 #> TNFRSF17          1.346841          0.000000          0.000000 #> ICAM3             4.599200          5.053963          0.000000 #> FAP               0.000000          0.000000          0.000000 #> GZMB              2.796814          4.367180          6.884087 #> TSC2              0.000000          0.000000          0.000000 #>          X49_Y-100..Plasma X50_Y-100..Plasma X43_Y-97..Plasma X43_Y-100..Plasma #> PDK4              0.000000          0.000000         0.000000          0.000000 #> TNFRSF17          4.008316          2.004158         1.961036          3.741288 #> ICAM3             0.000000          2.288148         2.302635          3.741288 #> FAP               0.000000          0.000000         0.000000          0.000000 #> GZMB              0.000000          2.288148         0.000000          0.000000 #> TSC2              0.000000          0.000000         0.000000          0.000000"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/HeatmapView.html","id":null,"dir":"Reference","previous_headings":"","what":"Draw Heatmap — HeatmapView","title":"Draw Heatmap — HeatmapView","text":"Draw Heatmap","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/HeatmapView.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Draw Heatmap — HeatmapView","text":"","code":"HeatmapView(   mat,   breaks = c(0, 0.6, 1.2),   colors = c(\"#ffffd9\", \"#edf8b1\", \"#225ea8\"),   na_col = \"grey\",   name = \"hmap\",   cluster_rows = FALSE,   row_dend_side = c(\"left\", \"right\"),   cluster_cols = FALSE,   column_dend_side = c(\"top\", \"bottom\"),   show_row_names = TRUE,   row_names_side = \"left\",   row_names_gp = gpar(fontsize = 12),   row_names_rot = 0,   show_column_names = TRUE,   column_names_side = \"bottom\",   column_names_gp = gpar(fontsize = 12),   column_names_rot = 90,   show_legend = TRUE,   top_ann = NULL,   top_ann_col = NULL,   show_top_legend = show_legend,   bott_ann = NULL,   bott_ann_col = NULL,   show_bott_legend = show_legend,   left_ann = NULL,   left_ann_col = NULL,   show_left_legend = show_legend,   right_ann = NULL,   right_ann_col = NULL,   show_right_legend = show_legend,   show_ann_name = TRUE,   annotation_legend_param = list(),   row_split = NULL,   column_split = NULL,   show_heatmap_legend = TRUE,   legend_title = NULL,   legend_title_position = \"lefttop\",   legend_direction = \"vertical\",   legend_title_gp = gpar(fontsize = 12),   legend_labels_gp = gpar(fontsize = 12),   legend_height = 2,   legend_width = 0.3,   legend_side = \"right\",   ... )"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/HeatmapView.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Draw Heatmap — HeatmapView","text":"mat Matrix like object. breaks vector indicating numeric breaks. colors vector colors correspond values breaks. na_col Color NA values. name Heatmap name. cluster_rows ComplexHeatmap::Heatmap. row_dend_side ComplexHeatmap::Heatmap. cluster_cols ComplexHeatmap::Heatmap. column_dend_side ComplexHeatmap::Heatmap. show_row_names ComplexHeatmap::Heatmap. row_names_side ComplexHeatmap::Heatmap. row_names_gp ComplexHeatmap::Heatmap. row_names_rot ComplexHeatmap::Heatmap. show_column_names ComplexHeatmap::Heatmap. column_names_side ComplexHeatmap::Heatmap. column_names_gp ComplexHeatmap::Heatmap. column_names_rot ComplexHeatmap::Heatmap. show_legend Whether show annotation legends. top_ann data frame. column treated simple annotation. data frame must column names. Can also HeatmapAnnotation-class object. top_ann_col list colors contain color mapping df. show_top_legend Whether show annotation legends. bott_ann top_ann. bott_ann_col list colors contain color mapping df. show_bott_legend Whether show annotation legends. left_ann top_ann. left_ann_col list colors contain color mapping df. show_left_legend Whether show annotation legends. right_ann top_ann. right_ann_col list colors contain color mapping df. show_right_legend Whether show annotation legends. show_ann_name Whether show annotation names. annotation_legend_param list contains parameters annotation legends. row_split vector data frame rows split. cluster_rows clustering object, split can single number indicating split dendrogram cutree. column_split row_split. show_heatmap_legend Whether show legends. legend_title Character specifyin legend title. legend_title_position Position title relative legend. topleft, topcenter, leftcenter-rot lefttop-rot vertical legend leftcenter, lefttop horizontal legend. legend_direction Vertical horizontal? legend_title_gp Graphic parameters title. legend_labels_gp Graphic parameters labels. legend_height Height whole legend body. used vertical continous legend. legend_width Width whole legend body. used horizontal continous legend. legend_side Side put heatmap legend ... parameters draw.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/HeatmapView.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Draw Heatmap — HeatmapView","text":"`Heatmap-class` object.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/HeatmapView.html","id":"author","dir":"Reference","previous_headings":"","what":"Author","title":"Draw Heatmap — HeatmapView","text":"Wubing Zhang","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/HeatmapView.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Draw Heatmap — HeatmapView","text":"","code":"library(grid) library(SpatialEcoTyper) library(ComplexHeatmap) #> ======================================== #> ComplexHeatmap version 2.20.0 #> Bioconductor page: http://bioconductor.org/packages/ComplexHeatmap/ #> Github page: https://github.com/jokergoo/ComplexHeatmap #> Documentation: http://jokergoo.github.io/ComplexHeatmap-reference #>  #> If you use it in published research, please cite either one: #> - Gu, Z. Complex Heatmap Visualization. iMeta 2022. #> - Gu, Z. Complex heatmaps reveal patterns and correlations in multidimensional  #>     genomic data. Bioinformatics 2016. #>  #>  #> The new InteractiveComplexHeatmap package can directly export static  #> complex heatmaps into an interactive Shiny app with zero effort. Have a try! #>  #> This message can be suppressed by: #>   suppressPackageStartupMessages(library(ComplexHeatmap)) #> ========================================  dat = matrix(rnorm(100), 10) rownames(dat) = letters[1:10] colnames(dat) = letters[11:20] rowann = data.frame(Group = rep(letters[1:2], each=5), index = 1:10) colann = data.frame(Group = rep(letters[1:2], each=5), index = 11:20) HeatmapView(dat, left_ann = rowann, top_ann = colann) #> Loading required package: pals"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/Integrate.html","id":null,"dir":"Reference","previous_headings":"","what":"Integrate Spatial Clusters From Multiple Samples Via Similarity Network Fusion — Integrate","title":"Integrate Spatial Clusters From Multiple Samples Via Similarity Network Fusion — Integrate","text":"function identifies conserved spatial ecotypes based cell type specific gene expression signature spatial clusters samples.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/Integrate.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Integrate Spatial Clusters From Multiple Samples Via Similarity Network Fusion — Integrate","text":"","code":"Integrate(   avgexprs,   Region = NULL,   nfeatures = 3000,   min.features = 5,   minibatch = 5000,   ncores = 1 )"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/Integrate.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Integrate Spatial Clusters From Multiple Samples Via Similarity Network Fusion — Integrate","text":"avgexprs Gene expression signature spatial clusters, column represents spatial cluster. Region character vector specifying region annotations spatial clusters. nfeatures Integer specifying maximum number top variable genes select cell type. min.features Integer specifying minimum number shared features (genes) required across samples. minibatch Integer specifying number columns process minibatch SNF analysis. Default 5000. option splits matrix smaller chunks (minibatch), thus reducing memory usage. ncores Integer specifying number cores parallel processing. Default 1.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/Integrate.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Integrate Spatial Clusters From Multiple Samples Via Similarity Network Fusion — Integrate","text":"Integrated similarity matrix spatial clusters across samples.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/IntegrateSpatialEcoTyper.html","id":null,"dir":"Reference","previous_headings":"","what":"Integrate Multiple Spatial Transcriptomics Datasets to Identify Conserved Spatial Ecotypes — IntegrateSpatialEcoTyper","title":"Integrate Multiple Spatial Transcriptomics Datasets to Identify Conserved Spatial Ecotypes — IntegrateSpatialEcoTyper","text":"Integrate Multiple Spatial Transcriptomics Datasets Identify Conserved Spatial Ecotypes","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/IntegrateSpatialEcoTyper.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Integrate Multiple Spatial Transcriptomics Datasets to Identify Conserved Spatial Ecotypes — IntegrateSpatialEcoTyper","text":"","code":"IntegrateSpatialEcoTyper(   SpatialEcoTyper_list,   data_list,   outdir = \"./\",   normalization.method = \"None\",   nmf_ranks = 10,   nrun.per.rank = 30,   min.coph = 0.95,   nfeatures = 3000,   min.features = 10,   Region = NULL,   subresolution = 30,   minibatch = 5000,   ncores = 1,   seed = 1 )"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/IntegrateSpatialEcoTyper.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Integrate Multiple Spatial Transcriptomics Datasets to Identify Conserved Spatial Ecotypes — IntegrateSpatialEcoTyper","text":"SpatialEcoTyper_list named list SpatialEcoTyper results, item represents list returned SpatialEcoTyper function. data_list named list expression matrices matrix represents gene expression data used SpatialEcoTyper analysis. list name match SpatialEcoTyper_list. outdir Directory results saved. Defaults current directory subdirectory named \"SpatialEcoTyper_results_\" followed current date. normalization.method Method normalizing expression data. Options include \"None\" (default), \"SCT\", methods compatible Seurat's `NormalizeData` function. nmf_ranks Integer vector specifying number clusters (10 default). integer vector supplied, function test supplied numbers select optimal number, takes time. nrun.per.rank integer specifying number runs per rank NMF (default: 30). min.coph Numeric specifying minimum cophenetic coefficient required rank optimal. nfeatures integer specifying maximum number top variable genes select cell type. min.features integer specifying minimum number shared features (genes) required across samples. Region character string specifying column name metadata data frames containing region annotations (default: NULL). Pathologist annotation recommended available. subresolution numeric specifying resolution clustering within sample. minibatch Integer specifying number columns process minibatch SNF analysis. Default 5000. option splits matrix smaller chunks (minibatch), thus reducing memory usage. ncores integer specifying number cores parallel processing. Default 1. seed integer used seed random number generator NMF analysis.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/IntegrateSpatialEcoTyper.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Integrate Multiple Spatial Transcriptomics Datasets to Identify Conserved Spatial Ecotypes — IntegrateSpatialEcoTyper","text":"","code":"# See https://digitalcytometry.github.io/spatialecotyper/docs/articles/Integration.html"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/MultiSpatialEcoTyper.html","id":null,"dir":"Reference","previous_headings":"","what":"Integrate Multiple Spatial Transcriptomics Datasets to Identify Conserved Spatial Ecotypes — MultiSpatialEcoTyper","title":"Integrate Multiple Spatial Transcriptomics Datasets to Identify Conserved Spatial Ecotypes — MultiSpatialEcoTyper","text":"function performs SpatialEcoTyper analysis multiple spatial transcriptomics datasets. normalizes input data, performs SpatialEcoTyper analysis dataset, integrates results across samples.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/MultiSpatialEcoTyper.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Integrate Multiple Spatial Transcriptomics Datasets to Identify Conserved Spatial Ecotypes — MultiSpatialEcoTyper","text":"","code":"MultiSpatialEcoTyper(   data_list,   metadata_list,   outdir = \"./\",   normalization.method = \"None\",   nmf_ranks = 10,   nrun.per.rank = 30,   min.coph = 0.95,   radius = 50,   min.cts.per.region = 1,   nfeatures = 3000,   min.features = 10,   Region = NULL,   subresolution = 30,   minibatch = 5000,   ncores = 1,   seed = 1,   filter.region.by.celltypes = NULL,   ... )"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/MultiSpatialEcoTyper.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Integrate Multiple Spatial Transcriptomics Datasets to Identify Conserved Spatial Ecotypes — MultiSpatialEcoTyper","text":"data_list named list expression matrices matrix represents gene expression data sample. columns matrix correspond cells, rows correspond genes. Sample names used list names. Otherwise, samples named 'Sample1' 'SampleN'. metadata_list named list metadata data frames data frame contains metadata corresponding cells expression matrices. row correspond column (cell) expression matrices. metadata include least three columns, including X, Y CellType. outdir Directory results saved. Defaults current directory subdirectory named \"SpatialEcoTyper_results_\" followed current date. normalization.method Method normalizing expression data. Options include \"None\" (default), \"SCT\", methods compatible Seurat's `NormalizeData` function. nmf_ranks Integer vector specifying number clusters (10 default). integer vector supplied, function test supplied numbers select optimal number, takes time. nrun.per.rank integer specifying number runs per rank NMF (default: 30). min.coph Numeric specifying minimum cophenetic coefficient required rank optimal. radius Numeric specifying radius (units spatial coordinates) defining spatial neighborhoods around cell. Default 50. min.cts.per.region Integer specifying minimum number cell types required microregion. nfeatures integer specifying maximum number top variable genes select cell type. min.features integer specifying minimum number shared features (genes) required across samples. Region Character string specifying column name metadata data frames containing region annotations (default: NULL). Pathologist annotation recommended available. subresolution Numeric specifying resolution clustering within sample. minibatch Integer specifying number columns process minibatch SNF analysis. Default 5000. option splits matrix smaller chunks (minibatch), thus reducing memory usage. ncores Integer specifying number cores parallel processing. Default 1. seed integer used seed random number generator NMF analysis. filter.region..celltypes character vector specifying cell types include analysis. spatial microregions contain least one specified cell types analyzed, regions lacking cell types excluded SE discovery process. NULL, spatial microregions included, regardless cell type composition. ... Additional arguments passed `SpatialEcoTyper` function.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/MultiSpatialEcoTyper.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Integrate Multiple Spatial Transcriptomics Datasets to Identify Conserved Spatial Ecotypes — MultiSpatialEcoTyper","text":"function saves results specified output directory.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/MultiSpatialEcoTyper.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Integrate Multiple Spatial Transcriptomics Datasets to Identify Conserved Spatial Ecotypes — MultiSpatialEcoTyper","text":"function takes list gene expression matrices corresponding metadata,          normalizes data specified, performs SpatialEcoTyper sample,          integrates results across multiple samples identify conserved spatial ecotypes.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/MultiSpatialEcoTyper.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Integrate Multiple Spatial Transcriptomics Datasets to Identify Conserved Spatial Ecotypes — MultiSpatialEcoTyper","text":"","code":"# See https://digitalcytometry.github.io/spatialecotyper/docs/articles/Integration.html"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/NMFGenerateW.html","id":null,"dir":"Reference","previous_headings":"","what":"Train SE Deconvolution Model — NMFGenerateW","title":"Train SE Deconvolution Model — NMFGenerateW","text":"function trains Non-negative Matrix Factorization (NMF) model SE deconvolution based given spatial ecotype fractions gene expression matrix. Prior NMF, gene scaled mean 0 unit variance. satisfy non-negativity requirement NMF, expression matrix processed using posneg transformation, converts expression matrix two matrices, one containing positive values containing negative values sign inverted. two matrices subsequently concatenated produce training data.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/NMFGenerateW.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Train SE Deconvolution Model — NMFGenerateW","text":"","code":"NMFGenerateW(   Fracs,   ExpMat,   scale = TRUE,   nfeature = 2000,   nfeature.per.se = 50,   method = \"brunet\" )"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/NMFGenerateW.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Train SE Deconvolution Model — NMFGenerateW","text":"Fracs fraction matrix, rows samples. ExpMat gene expression matrix genes rows samples columns. scale Logical indicating whether scale gene expression matrix. Default TRUE. nfeature Integer specifying top variable features training models (default: 2000). nfeature.per.se Integer specifying maximal number features select SE (default: 50). method character string specifying NMF method use. Default \"brunet\".","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/NMFGenerateW.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Train SE Deconvolution Model — NMFGenerateW","text":"matrix containing basis NMF W matrix rows features columns SEs.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/NMFGenerateWList.html","id":null,"dir":"Reference","previous_headings":"","what":"Train Cell Type-Specific NMF Models for Recovering Spatial EcoTypes — NMFGenerateWList","title":"Train Cell Type-Specific NMF Models for Recovering Spatial EcoTypes — NMFGenerateWList","text":"function trains cell type-specific NMF (Non-Negative Matrix Factorization) models recover SE-specific cell states single-cell data, part Spatial EcoTyper analysis workflow. downsamples cells training dataset size large, selects subset features highest specificity.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/NMFGenerateWList.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Train Cell Type-Specific NMF Models for Recovering Spatial EcoTypes — NMFGenerateWList","text":"","code":"NMFGenerateWList(   scdata,   scmeta,   CellType = \"CellType\",   SE = \"SE\",   scale = TRUE,   Sample = NULL,   balance.sample = TRUE,   nfeature = 2000,   nfeature.per.se = 50,   min.cells = 20,   downsample = 2500,   ncores = 1,   seed = 2024 )"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/NMFGenerateWList.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Train Cell Type-Specific NMF Models for Recovering Spatial EcoTypes — NMFGenerateWList","text":"scdata Numeric matrix containing single-cell expression data. scmeta Data frame containing metadata information associated single-cell data, including cell types spatial clusters. CellType Character string specifying column name metadata data frame containing cell type annotations. SE Character string specifying column name metadata data frame containing spatial ecotype annotations. scale Boolean specifying whether perform univariance normalization training models (default: TRUE). Sample Character string specifying column name metadata data frame containing sample annotations. specified, univariance normalization performed within sample. balance.sample Boolean specifying whether perform balance cells samples training models (default: TRUE). nfeature Integer specifying top variable features training models (default: 2000). nfeature.per.se Integer specifying maximal number features select SE (default: 50). min.cells Integer specifying minimal number cells required SE cell state. downsample Integer specifying number cells per cell type (downsampling) training NMF models (default: 2500). ncores Integer specifying number CPU cores use parallel processing. seed Integer specifying seed random sampling downsampling.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/NMFGenerateWList.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Train Cell Type-Specific NMF Models for Recovering Spatial EcoTypes — NMFGenerateWList","text":"list cell type-specific NMF models, represented corresponding factorization matrix W.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/NMFpredict.html","id":null,"dir":"Reference","previous_headings":"","what":"Prediction Using Pretrained NMF Model — NMFpredict","title":"Prediction Using Pretrained NMF Model — NMFpredict","text":"function uses pretrained NMF models recover cell states / spatial ecotypes. takes factorization matrix W representing pretrained NMF model numeric gene expression matrix.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/NMFpredict.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Prediction Using Pretrained NMF Model — NMFpredict","text":"","code":"NMFpredict(W, testdat, scale = FALSE, ncell.per.run = 500)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/NMFpredict.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Prediction Using Pretrained NMF Model — NMFpredict","text":"W Matrix representing factorization matrix W pretrained NMF model. testdat Numeric matrix containing new data NMF scores predicted. scale Logical indicating whether scale input data. ncell.per.run Integer specifying maximum number cells per NMF prediction run avoid memory issues.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/NMFpredict.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Prediction Using Pretrained NMF Model — NMFpredict","text":"matrix representing NMF prediction scores.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/NMFpredict.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Prediction Using Pretrained NMF Model — NMFpredict","text":"","code":"library(googledrive) drive_deauth() # no Google sign-in is required drive_download(as_id(\"14QvmgISxaArTzWt_UHvf55aAYN2zm84Q\"), \"SKCM_RNASeqV2.geneExp.rds\",                     overwrite = TRUE) #> File downloaded: #> • SKCM_RNASeqV2.geneExp.rds  #> Saved locally as: #> • SKCM_RNASeqV2.geneExp.rds bulkdata <- readRDS(\"SKCM_RNASeqV2.geneExp.rds\") W <- readRDS(file.path(system.file(\"extdata\", package = \"SpatialEcoTyper\"), \"Bulk_SE_Recovery_W.rds\"))  # Predict SE abundances in bulk tumors preds <- NMFpredict(W = W, bulkdata, scale = TRUE) head(preds[, 1:5]) #>       TCGA-3N-A9WB-06 TCGA-3N-A9WC-06 TCGA-3N-A9WD-06 TCGA-BF-A1PU-01 #> nonSE      0.10378493     0.031103139     0.469932888      0.12913097 #> SE1        0.08326065     0.063022079     0.151414386      0.18470256 #> SE2        0.25368726     0.051110136     0.068248720      0.09710288 #> SE3        0.09417615     0.173416088     0.004969678      0.06966202 #> SE4        0.07931696     0.028829349     0.056418588      0.16008800 #> SE5        0.05088193     0.003203951     0.056310297      0.05303787 #>       TCGA-BF-A1PV-01 #> nonSE      0.10221472 #> SE1        0.05277487 #> SE2        0.05740510 #> SE3        0.15960054 #> SE4        0.12876903 #> SE5        0.12002292"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/PreprocessST.html","id":null,"dir":"Reference","previous_headings":"","what":"Preprocess Spatial Transcriptomics Data — PreprocessST","title":"Preprocess Spatial Transcriptomics Data — PreprocessST","text":"function preprocesses single-cell spatial transcriptomics data filtering low-quality genes cells based specified thresholds. ensures genes expressed minimum number cells cells expressing minimum number features retained. Additionally, reformats metadata include spatial coordinates (X Y).","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/PreprocessST.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Preprocess Spatial Transcriptomics Data — PreprocessST","text":"","code":"PreprocessST(   expdat,   metadata,   min.cells = 3,   min.features = 5,   X = \"X\",   Y = \"Y\" )"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/PreprocessST.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Preprocess Spatial Transcriptomics Data — PreprocessST","text":"expdat matrix data frame representing gene expression data, rows correspond genes columns correspond cells. metadata data frame containing metadata associated cell. Must include spatial coordinates (e.g., X Y) well cell-specific annotations. row names `metadata` must match column names `expdat`. min.cells integer specifying minimum number cells gene must expressed retained (default 3). min.features integer specifying minimum number features (genes) cell must express retained (default 5). X string specifying column name metadata data frame represents X spatial coordinate (default \"X\"). Y string specifying column name metadata data frame represents Y spatial coordinate (default \"Y\").","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/PreprocessST.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Preprocess Spatial Transcriptomics Data — PreprocessST","text":"list containing two elements: expdat filtered matrix gene expression data, converted sparse matrix metadata filtered data frame metadata, aligned filtered gene expression data, including reformatted spatial coordinates.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/PreprocessST.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Preprocess Spatial Transcriptomics Data — PreprocessST","text":"","code":"library(SpatialEcoTyper) library(data.table) library(googledrive) drive_deauth() # no Google sign-in is required drive_download(as_id(\"1CgUOQKrWY_TG61o5aw7J9LZzE20D6NuI\"),                     \"HumanMelanomaPatient1_subset_scmeta.tsv\", overwrite = TRUE) #> File downloaded: #> • HumanMelanomaPatient1_subset_scmeta.tsv #>    #> Saved locally as: #> • HumanMelanomaPatient1_subset_scmeta.tsv drive_download(as_id(\"1CoQmU3u8MoVC8RbLUvTDQmOuJJ703HHB\"),               \"HumanMelanomaPatient1_subset_counts.tsv.gz\", overwrite = TRUE) #> File downloaded: #> • HumanMelanomaPatient1_subset_counts.tsv.gz #>    #> Saved locally as: #> • HumanMelanomaPatient1_subset_counts.tsv.gz scdata <- fread(\"HumanMelanomaPatient1_subset_counts.tsv.gz\",                 sep = \"\\t\",header = TRUE, data.table = FALSE) rownames(scdata) <- scdata[, 1] scdata <- as.matrix(scdata[, -1]) scmeta <- read.table(\"HumanMelanomaPatient1_subset_scmeta.tsv\",                      sep = \"\\t\", header = TRUE, row.names = 1) processed <- PreprocessST(expdat = scdata, scmeta, X = \"X\", Y = \"Y\",                           min.cells = 3, min.features = 5) #> 2024-11-07 01:13:45.324804 Remove 87 genes expressed in fewer than 3 cells head(processed$metadata) #>                                         X         Y   CellType CellTypeName #> HumanMelanomaPatient1__cell_3655 1894.706 -6367.766 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3657 1942.480 -6369.602 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3658 1963.007 -6374.026 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3660 1981.600 -6372.266 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3661 1742.939 -6374.851 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3663 1921.683 -6383.309 Fibroblast  Fibroblasts #>                                  Region Dist2Interface #> HumanMelanomaPatient1__cell_3655 Stroma      -883.1752 #> HumanMelanomaPatient1__cell_3657 Stroma      -894.8463 #> HumanMelanomaPatient1__cell_3658 Stroma      -904.1115 #> HumanMelanomaPatient1__cell_3660 Stroma      -907.8909 #> HumanMelanomaPatient1__cell_3661 Stroma      -874.2712 #> HumanMelanomaPatient1__cell_3663 Stroma      -903.6559 head(processed$expdat) #> 6 x 27907 sparse Matrix of class \"dgCMatrix\" #>   [[ suppressing 34 column names ‘HumanMelanomaPatient1__cell_3655’, ‘HumanMelanomaPatient1__cell_3657’, ‘HumanMelanomaPatient1__cell_3658’ ... ]] #>                                                                              #> PDK4     . 1 1 . . . . . . . . . . . . 1 . 2 1 . 1 . . . 2 2 . . . . . . . 1 #> TNFRSF17 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . #> ICAM3    . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . #> FAP      1 . . . . 1 2 1 . 1 . 1 . . . . . . . . 1 . . . . . 1 1 . 1 . . . 1 #> GZMB     . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 . . . . #> TSC2     . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . #>                 #> PDK4     ...... #> TNFRSF17 ...... #> ICAM3    ...... #> FAP      ...... #> GZMB     ...... #> TSC2     ...... #>  #>  .....suppressing 27873 columns in show(); maybe adjust options(max.print=, width=) #>  .............................."},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/RecoverSE.html","id":null,"dir":"Reference","previous_headings":"","what":"Recovery of SEs Using Pretrained NMF Models — RecoverSE","title":"Recovery of SEs Using Pretrained NMF Models — RecoverSE","text":"function can recover SEs Visium, scRNA-seq data single-cell spatial data.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/RecoverSE.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Recovery of SEs Using Pretrained NMF Models — RecoverSE","text":"","code":"RecoverSE(dat, scale = TRUE, Ws = NULL, celltypes = NULL, se_results = NULL)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/RecoverSE.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Recovery of SEs Using Pretrained NMF Models — RecoverSE","text":"dat numeric matrix gene expression data, single-cell spatial transcriptomics, scRNA-seq spot-resolution spatial transcriptomics data. scale Logical indicating whether scale input data predictions. Ws list cell-type-specific W matrices used recover SE-specific cell states. element list named corresponding cell type contain W matrix NMF model. celltypes Character string specifying cell type annotations, required scRNA-seq single-cell spatial data. se_results list including seurat object metadata spatial cluster annotations (SE column) returned SpatialEcoTyper. supplied, `dat` single cell gene expression data used SpatialEcoTyper analysis.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/RecoverSE.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Recovery of SEs Using Pretrained NMF Models — RecoverSE","text":"Depending input data: - single-cell data: vector predicted SEs cell. - spot-resolution data (e.g., Visium): matrix SE abundances across spots.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/RecoverSE.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Recovery of SEs Using Pretrained NMF Models — RecoverSE","text":"","code":"# see https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_scRNA.html # see https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_Spatial.html"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/SNF2.html","id":null,"dir":"Reference","previous_headings":"","what":"Enhanced Similarity Network Fusion — SNF2","title":"Enhanced Similarity Network Fusion — SNF2","text":"Similarity Network Fusion (SNF) integrates multiple views (similarity matrices) construct overall status matrix. function adopted SNFtool (https://github.com/maxconway/SNFtool/) enhanced unsupervised analysis spatial ecosystem. new function supports sparse matrix missing data input matrices.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/SNF2.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Enhanced Similarity Network Fusion — SNF2","text":"","code":"SNF2(Wall, K = 50, t = 5, minibatch = 5000, ncores = 1, verbose = FALSE)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/SNF2.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Enhanced Similarity Network Fusion — SNF2","text":"Wall List similarity matrices. element list square, symmetric matrix shows affinities data points certain view. K Number neighbors K-nearest neighbors part algorithm. t Number iterations diffusion process. minibatch Integer specifying number columns process minibatch. Default 5000. option splits matrix smaller chunks (minibatch), thus reducing memory usage. ncores Integer specifying number CPU cores use parallel processing. verbose Boolean specifying whether show progress messages.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/SNF2.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Enhanced Similarity Network Fusion — SNF2","text":"fused matrix.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/SpatialEcoTyper.html","id":null,"dir":"Reference","previous_headings":"","what":"Identify Spatial EcoTypes from Single-cell Spatial Data (A Single Sample) — SpatialEcoTyper","title":"Identify Spatial EcoTypes from Single-cell Spatial Data (A Single Sample) — SpatialEcoTyper","text":"function identifies spatially distinct cellular ecosystems (SE) single sample.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/SpatialEcoTyper.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Identify Spatial EcoTypes from Single-cell Spatial Data (A Single Sample) — SpatialEcoTyper","text":"","code":"SpatialEcoTyper(   normdata,   metadata,   outprefix = \"SE\",   radius = 50,   resolution = 0.5,   nfeatures = 3000,   min.cts.per.region = 1,   npcs = 20,   k.sn = 50,   k = 20,   min.cells = 5,   min.features = 10,   iterations = 5,   minibatch = 5000,   ncores = 1,   grid.size = round(radius * 1.4),   filter.region.by.celltypes = NULL )"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/SpatialEcoTyper.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Identify Spatial EcoTypes from Single-cell Spatial Data (A Single Sample) — SpatialEcoTyper","text":"normdata matrix representing normalized gene expression data, rows correspond genes columns correspond cells. metadata data frame containing metadata associated cell. Must include spatial coordinates (e.g., X Y) well cell type annotations. row names metadata must match column names normdata. outprefix Character string specifying prefix output file names. radius Numeric specifying radius (units spatial coordinates) defining spatial neighborhoods around cell. Default 50. resolution Numeric specifying resolution Louvain clustering (default: 0.5). nfeatures Integer specifying number top variable features (default: 3000) used PCA. min.cts.per.region Integer specifying minimum number cell types required microregion. npcs Integer specifying number principal components (PCs) (default: 20). k.sn Integer specifying number spatial nearest neighbors (default: 50) constructing similarity network. k Integer specifying number spatial nearest neighbors (default: 20) used construct spatial meta-cells. min.cells Minimum number cells / spatial-meta-cells (default: 5)  expressing feature/gene. min.features Minimum number features (default: 10) detected cell / spatial-meta-cell. iterations Integer specifying number iterations (default: 5) SNF analysis. minibatch Integer specifying number columns process minibatch SNF analysis. Default 5000. option splits matrix smaller chunks (minibatch), thus reducing memory usage. ncores Integer specifying number CPU cores use parallel processing. grid.size Numeric specifying grid size spatial discretization coordinates. default, size determined based specified radius (radius*1.4 µm). Increasing grid.size downsample microregions expedite analysis, might eliminate cells located bins SE discovery analysis. filter.region..celltypes character vector specifying cell types include analysis. spatial microregions contain least one specified cell types analyzed, regions lacking cell types excluded SE discovery process. NULL, spatial microregions included, regardless cell type composition. #' @return list containing two elements: obj seurat object constructed fused similarity network sptial microregions metadata Updated metadata, new column (`SE`) added","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/SpatialEcoTyper.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Identify Spatial EcoTypes from Single-cell Spatial Data (A Single Sample) — SpatialEcoTyper","text":"","code":"# See https://digitalcytometry.github.io/spatialecotyper/docs/articles/SingleSample.html suppressPackageStartupMessages(library(dplyr)) suppressPackageStartupMessages(library(ggplot2)) suppressPackageStartupMessages(library(parallel)) suppressPackageStartupMessages(library(Seurat)) suppressPackageStartupMessages(library(data.table)) suppressPackageStartupMessages(library(googledrive)) suppressPackageStartupMessages(library(R.utils)) library(SpatialEcoTyper)  drive_deauth() # Disable Google sign-in requirement drive_download(as_id(\"13Rc5Rsu8jbnEYYfUse-xQ7ges51LcI7n\"), \"HumanMelanomaPatient1_subset_counts.tsv.gz\") #> Error in drive_download(as_id(\"13Rc5Rsu8jbnEYYfUse-xQ7ges51LcI7n\"), \"HumanMelanomaPatient1_subset_counts.tsv.gz\"): Local `path` already exists and overwrite is `FALSE`: #> • HumanMelanomaPatient1_subset_counts.tsv.gz drive_download(as_id(\"12xcZNhpT-xbhcG8kX1QAdTeM9TKeFAUW\"), \"HumanMelanomaPatient1_subset_scmeta.tsv\") #> Error in drive_download(as_id(\"12xcZNhpT-xbhcG8kX1QAdTeM9TKeFAUW\"), \"HumanMelanomaPatient1_subset_scmeta.tsv\"): Local `path` already exists and overwrite is `FALSE`: #> • HumanMelanomaPatient1_subset_scmeta.tsv  # Load single-cell gene expression matrix. Rows are genes, columns are cells. scdata <- fread(\"HumanMelanomaPatient1_subset_counts.tsv.gz\",                 sep = \"\\t\",header = TRUE, data.table = FALSE) rownames(scdata) <- scdata[, 1]  # set genes as row names scdata <- as.matrix(scdata[, -1]) normdata <- NormalizeData(scdata) head(normdata[, 1:5]) #>          HumanMelanomaPatient1__cell_3655 HumanMelanomaPatient1__cell_3657 #> PDK4                             0.000000                         4.221184 #> TNFRSF17                         0.000000                         0.000000 #> ICAM3                            0.000000                         0.000000 #> FAP                              3.552438                         0.000000 #> GZMB                             0.000000                         0.000000 #> TSC2                             0.000000                         0.000000 #>          HumanMelanomaPatient1__cell_3658 HumanMelanomaPatient1__cell_3660 #> PDK4                             3.208945                                0 #> TNFRSF17                         0.000000                                0 #> ICAM3                            0.000000                                0 #> FAP                              0.000000                                0 #> GZMB                             0.000000                                0 #> TSC2                             0.000000                                0 #>          HumanMelanomaPatient1__cell_3661 #> PDK4                                    0 #> TNFRSF17                                0 #> ICAM3                                   0 #> FAP                                     0 #> GZMB                                    0 #> TSC2                                    0  # Load single-cell metadata. Three columns are required, including X, Y, and CellType. Others are optional. scmeta <- read.table(\"HumanMelanomaPatient1_subset_scmeta.tsv\",                      sep = \"\\t\",header = TRUE, row.names = 1) scmeta <- scmeta[colnames(scdata), ] # match the cell ids in scdata and scmeta head(scmeta) #>                                         X         Y   CellType CellTypeName #> HumanMelanomaPatient1__cell_3655 1894.706 -6367.766 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3657 1942.480 -6369.602 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3658 1963.007 -6374.026 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3660 1981.600 -6372.266 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3661 1742.939 -6374.851 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3663 1921.683 -6383.309 Fibroblast  Fibroblasts #>                                  Region Dist2Interface #> HumanMelanomaPatient1__cell_3655 Stroma      -883.1752 #> HumanMelanomaPatient1__cell_3657 Stroma      -894.8463 #> HumanMelanomaPatient1__cell_3658 Stroma      -904.1115 #> HumanMelanomaPatient1__cell_3660 Stroma      -907.8909 #> HumanMelanomaPatient1__cell_3661 Stroma      -874.2712 #> HumanMelanomaPatient1__cell_3663 Stroma      -903.6559  se_results <- SpatialEcoTyper(normdata, scmeta,                               outprefix = \"Melanoma1_subset\",                               radius = 50, ncores = 2) #> 2024-11-07 01:13:47.274967 Remove 88 genes expressed in fewer than 5 cells #> 2024-11-07 01:13:47.599961 Construct spatial meta cells for each cell type #> \t\tTotal spatial microregions: 2315 #> \t\tTotal spatial meta cells: 7711 #> 2024-11-07 01:13:57.050384 PCA for each cell type #> 2024-11-07 01:13:58.415943 Construct cell-type-specific similarity network #> 2024-11-07 01:13:59.127738 Similarity network fusion #> 2024-11-07 01:13:59.129295 Normalize networks ... #> 2024-11-07 01:13:59.226963 Calculate the local transition matrix ... #> 2024-11-07 01:13:59.686673 Perform the diffusion ... #> \t2024-11-07 01:13:59.687456 Iteration: 1 #> \t2024-11-07 01:14:05.423195 Iteration: 2 #> \t2024-11-07 01:14:21.987019 Iteration: 3 #> \t2024-11-07 01:14:48.162873 Iteration: 4 #> \t2024-11-07 01:15:11.952116 Iteration: 5 #> 2024-11-07 01:15:38.286144 Create Seurat object and perform clustering analysis #> Warning: Data is of class dgeMatrix. Coercing to dgCMatrix. #> Warning: The default method for RunUMAP has changed from calling Python UMAP via reticulate to the R-native UWOT using the cosine metric #> To use Python UMAP via reticulate, set umap.method to 'umap-learn' and metric to 'correlation' #> This message will be shown once per session #> 2024-11-07 01:15:49.269557 The Seurat object is saved into Melanoma1_subset_SpatialEcoTyper_results.rds # Extract the Seurat object and updated single-cell metadata obj <- se_results$obj # A Seurat object obj #> An object of class Seurat  #> 2315 features across 2315 samples within 1 assay  #> Active assay: RNA (2315 features, 2315 variable features) #>  3 layers present: counts, data, scale.data #>  2 dimensional reductions calculated: pca, umap scmeta <- se_results$metadata %>% arrange(SE) # Updated single-cell meta data, with SE annotation added head(scmeta) #>                                         X         Y   CellType CellTypeName #> HumanMelanomaPatient1__cell_3661 1742.939 -6374.851 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3664 1706.253 -6383.428 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3666 1761.403 -6387.970 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3668 1841.514 -6389.663 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3670 1741.536 -6395.796 Fibroblast  Fibroblasts #> HumanMelanomaPatient1__cell_3674 1907.099 -6411.773 Fibroblast  Fibroblasts #>                                  Region Dist2Interface  SE #> HumanMelanomaPatient1__cell_3661 Stroma      -874.2712 SE0 #> HumanMelanomaPatient1__cell_3664 Stroma      -880.4758 SE0 #> HumanMelanomaPatient1__cell_3666 Stroma      -888.6271 SE0 #> HumanMelanomaPatient1__cell_3668 Stroma      -896.8484 SE0 #> HumanMelanomaPatient1__cell_3670 Stroma      -895.0259 SE0 #> HumanMelanomaPatient1__cell_3674 Stroma      -928.7076 SE0"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/SpatialView.html","id":null,"dir":"Reference","previous_headings":"","what":"Visualize Spatial Landscape of Cells / Spots — SpatialView","title":"Visualize Spatial Landscape of Cells / Spots — SpatialView","text":"Visualize Spatial Landscape Cells / Spots","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/SpatialView.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Visualize Spatial Landscape of Cells / Spots — SpatialView","text":"","code":"SpatialView(   obj,   by,   X = \"X\",   Y = \"Y\",   pt.shape = 20,   pt.size = 0.5,   pt.alpha = 1,   jitter = FALSE,   slot = \"data\",   coord.fix = FALSE,   highlight.cells = NULL,   control.cells = NULL,   ncol = 3,   bg.downsample = 2000,   bg.color = \"gray80\",   bg.size = 0.5,   bg.alpha = 0.7 )"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/SpatialView.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Visualize Spatial Landscape of Cells / Spots — SpatialView","text":"obj Seurat object data frame (cell names row names). feature name plotting, e.g. cell type, region, gene expression. X character specifying spatial coordinate x-axis. Y character specifying spatial coordinate y-axis. pt.shape Point shape plotting pt.size numeric specifying point size non-control cells. pt.alpha numeric specifying point transparency non-control cells. jitter boolean specifying whether add jitters cells. slot slot Seurat object pull feature . highlight.cells vector specifying cells highlighting. control.cells vector specifying control cells background. specified, non-highlighting cells considered control.cells. bg.downsample integer specifying aim downsampling control.cells. bg.color Color control cells. bg.size numeric specifying point size control cells. bg.alpha numeric specifying point transparency control cells.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/SpatialView.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Visualize Spatial Landscape of Cells / Spots — SpatialView","text":"ggplot object.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/SpatialView.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Visualize Spatial Landscape of Cells / Spots — SpatialView","text":"","code":"library(data.table) library(Seurat) library(SpatialEcoTyper) library(ggplot2) library(googledrive) drive_deauth() # no Google sign-in is required drive_download(as_id(\"1CgUOQKrWY_TG61o5aw7J9LZzE20D6NuI\"),                     \"HumanMelanomaPatient1_subset_scmeta.tsv\", overwrite = TRUE) #> File downloaded: #> • HumanMelanomaPatient1_subset_scmeta.tsv #>    #> Saved locally as: #> • HumanMelanomaPatient1_subset_scmeta.tsv scmeta <- fread(\"HumanMelanomaPatient1_subset_scmeta.tsv\",                 sep = \"\\t\",header = TRUE, data.table = FALSE)  # Visualize the cell type annotations in the tissue SpatialView(scmeta, by = \"CellType\", X = \"X\", Y = \"Y\") +             scale_color_manual(values = pals::kelly()[-1]) #> Scale for colour is already present. #> Adding another scale for colour, which will replace the existing scale.  SpatialView(scmeta, by = \"Region\", X = \"X\", Y = \"Y\") +             scale_color_brewer(type = \"qual\", palette = \"Set1\") #> Scale for colour is already present. #> Adding another scale for colour, which will replace the existing scale."},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/Znorm.html","id":null,"dir":"Reference","previous_headings":"","what":"Weighted / Unweighted Uni-variance Normalization — Znorm","title":"Weighted / Unweighted Uni-variance Normalization — Znorm","text":"Z-score normalization scales feature (gene) across cells mean 0 standard deviation 1. function allows optional weighted univariance normalization, cells grouped categorical variable.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/Znorm.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Weighted / Unweighted Uni-variance Normalization — Znorm","text":"","code":"Znorm(mat, groups = NULL)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/Znorm.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Weighted / Unweighted Uni-variance Normalization — Znorm","text":"mat matrix gene expression data, rows represent genes columns represent cells. groups character vector specifying group labels cell. provided, weighted univariance normalization performed.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/Znorm.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Weighted / Unweighted Uni-variance Normalization — Znorm","text":"matrix Z-score normalized gene expression data, rows representing genes columns representing cells.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/Znorm.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Weighted / Unweighted Uni-variance Normalization — Znorm","text":"","code":"library(Seurat) library(data.table) library(SpatialEcoTyper) library(googledrive) drive_deauth() # no Google sign-in is required drive_download(as_id(\"1CoQmU3u8MoVC8RbLUvTDQmOuJJ703HHB\"),               \"HumanMelanomaPatient1_subset_counts.tsv.gz\", overwrite = TRUE) #> File downloaded: #> • HumanMelanomaPatient1_subset_counts.tsv.gz #>    #> Saved locally as: #> • HumanMelanomaPatient1_subset_counts.tsv.gz scdata <- fread(\"HumanMelanomaPatient1_subset_counts.tsv.gz\",                 sep = \"\\t\",header = TRUE, data.table = FALSE) rownames(scdata) <- scdata[, 1] scdata <- as.matrix(scdata[, -1]) tmpobj <- CreateSeuratObject(scdata) %>%           SCTransform(clip.range = c(-10, 10), verbose = FALSE) #> Warning: Data is of class matrix. Coercing to dgCMatrix. seurat_version = as.integer(gsub(\"\\\\..*\", \"\", as.character(packageVersion(\"SeuratObject\")))) if(seurat_version<5){   normdata <- GetAssayData(tmpobj, \"data\") }else{   normdata <- tmpobj[[\"SCT\"]]$data } # Z-score normalization znorm_data <- Znorm(normdata) #> Centering and scaling data matrix head(znorm_data[, 1:5]) #>          HumanMelanomaPatient1__cell_3655 HumanMelanomaPatient1__cell_3657 #> PDK4                           -0.3183628                        2.5919742 #> TNFRSF17                       -0.1060717                       -0.1060717 #> ICAM3                          -0.4436469                       -0.4436469 #> FAP                             3.2256642                       -0.2634737 #> GZMB                           -0.2174644                       -0.2174644 #> TSC2                           -0.1316410                       -0.1316410 #>          HumanMelanomaPatient1__cell_3658 HumanMelanomaPatient1__cell_3660 #> PDK4                            2.5919742                       -0.3183628 #> TNFRSF17                       -0.1060717                       -0.1060717 #> ICAM3                          -0.4436469                       -0.4436469 #> FAP                            -0.2634737                       -0.2634737 #> GZMB                           -0.2174644                       -0.2174644 #> TSC2                           -0.1316410                       -0.1316410 #>          HumanMelanomaPatient1__cell_3661 #> PDK4                           -0.3183628 #> TNFRSF17                       -0.1060717 #> ICAM3                          -0.4436469 #> FAP                            -0.2634737 #> GZMB                           -0.2174644 #> TSC2                           -0.1316410  # Weighted Z-score normalization drive_download(as_id(\"12xcZNhpT-xbhcG8kX1QAdTeM9TKeFAUW\"),                      \"HumanMelanomaPatient1_subset_scmeta.tsv\",                     overwrite = TRUE, verbose = FALSE) #> Warning: The `verbose` argument of `drive_download()` is deprecated as of googledrive #> 2.0.0. #> ℹ Set `options(googledrive_quiet = TRUE)` to suppress all googledrive messages. #> ℹ For finer control, use `local_drive_quiet()` or `with_drive_quiet()`. #> ℹ googledrive's `verbose` argument will be removed in the future. scmeta <- fread(\"HumanMelanomaPatient1_subset_scmeta.tsv\",                 sep = \"\\t\",header = TRUE, data.table = FALSE) wtdznorm_data <- Znorm(normdata, groups = scmeta$Region) head(wtdznorm_data[, 1:5]) #> 6 x 5 Matrix of class \"dgeMatrix\" #>          HumanMelanomaPatient1__cell_3655 HumanMelanomaPatient1__cell_3657 #> PDK4                          -0.27144312                       2.29194978 #> TNFRSF17                      -0.09363659                      -0.09363659 #> ICAM3                         -0.38535691                      -0.38535691 #> FAP                            2.81145245                      -0.22714128 #> GZMB                          -0.19294377                      -0.19294377 #> TSC2                          -0.11586941                      -0.11586941 #>          HumanMelanomaPatient1__cell_3658 HumanMelanomaPatient1__cell_3660 #> PDK4                           2.29194978                      -0.27144312 #> TNFRSF17                      -0.09363659                      -0.09363659 #> ICAM3                         -0.38535691                      -0.38535691 #> FAP                           -0.22714128                      -0.22714128 #> GZMB                          -0.19294377                      -0.19294377 #> TSC2                          -0.11586941                      -0.11586941 #>          HumanMelanomaPatient1__cell_3661 #> PDK4                          -0.27144312 #> TNFRSF17                      -0.09363659 #> ICAM3                         -0.38535691 #> FAP                           -0.22714128 #> GZMB                          -0.19294377 #> TSC2                          -0.11586941"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/dot-Integrate.html","id":null,"dir":"Reference","previous_headings":"","what":"Integrate Spatial Clusters From Multiple Samples Via Similarity Network Fusion — .Integrate","title":"Integrate Spatial Clusters From Multiple Samples Via Similarity Network Fusion — .Integrate","text":"function identifies conserved spatial ecotypes based cell type specific gene expression signature spatial clusters samples.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/dot-Integrate.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Integrate Spatial Clusters From Multiple Samples Via Similarity Network Fusion — .Integrate","text":"","code":".Integrate(   avgexprs,   Region = NULL,   nfeatures = 3000,   min.features = 5,   ncores = 1 )"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/dot-Integrate.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Integrate Spatial Clusters From Multiple Samples Via Similarity Network Fusion — .Integrate","text":"avgexprs Gene expression signature spatial clusters, column represents spatial cluster. Region character vector specifying region annotations spatial clusters. nfeatures Integer specifying maximum number top variable genes select cell type. min.features Integer specifying minimum number shared features (genes) required across samples. ncores Integer specifying number cores parallel processing. Default 1.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/dot-Integrate.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Integrate Spatial Clusters From Multiple Samples Via Similarity Network Fusion — .Integrate","text":"Integrated similarity matrix spatial clusters across samples.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/drawRectangleAnnotation.html","id":null,"dir":"Reference","previous_headings":"","what":"Draw Rectangle Annotations — drawRectangleAnnotation","title":"Draw Rectangle Annotations — drawRectangleAnnotation","text":"function draw rectangle grids based given row column factors.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/drawRectangleAnnotation.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Draw Rectangle Annotations — drawRectangleAnnotation","text":"","code":"drawRectangleAnnotation(rows, columns)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/drawRectangleAnnotation.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Draw Rectangle Annotations — drawRectangleAnnotation","text":"rows vector row identifiers. columns vector column identifiers.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/drawRectangleAnnotation.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Draw Rectangle Annotations — drawRectangleAnnotation","text":"","code":"library(grid) library(SpatialEcoTyper) library(ComplexHeatmap)  dat = matrix(rnorm(100), 10) rownames(dat) = letters[1:10] colnames(dat) = letters[11:20] rowann = data.frame(Group = rep(letters[1:2], each=5), index = 1:10) colann = data.frame(Group = rep(letters[1:2], each=5), index = 11:20) HeatmapView(dat, left_ann = rowann, top_ann = colann) drawRectangleAnnotation(rowann$Group, colann$Group)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/draw_rectangle_annotation.html","id":null,"dir":"Reference","previous_headings":"","what":"Draw Rectangle Annotations — draw_rectangle_annotation","title":"Draw Rectangle Annotations — draw_rectangle_annotation","text":"function draw rectangle grids based given row column factors.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/draw_rectangle_annotation.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Draw Rectangle Annotations — draw_rectangle_annotation","text":"","code":"draw_rectangle_annotation(rows, columns)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/draw_rectangle_annotation.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Draw Rectangle Annotations — draw_rectangle_annotation","text":"rows vector row identifiers. columns vector column identifiers.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/draw_rectangle_annotation.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Draw Rectangle Annotations — draw_rectangle_annotation","text":"","code":"library(grid) library(SpatialEcoTyper) library(ComplexHeatmap)  dat = matrix(rnorm(100), 10) rownames(dat) = letters[1:10] colnames(dat) = letters[11:20] rowann = data.frame(Group = rep(letters[1:2], each=5), index = 1:10) colann = data.frame(Group = rep(letters[1:2], each=5), index = 11:20) HeatmapView(dat, left_ann = rowann, top_ann = colann) draw_rectangle_annotation(rowann$Group, colann$Group)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/fillspots.html","id":null,"dir":"Reference","previous_headings":"","what":"Handle Missing Values — fillspots","title":"Handle Missing Values — fillspots","text":"function fills missing spatial regions similarity network matrices zeros. ensures matrices list set spatial regions.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/fillspots.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Handle Missing Values — fillspots","text":"","code":"fillspots(snlist)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/fillspots.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Handle Missing Values — fillspots","text":"snlist list similarity network matrices rows columns correspond spatial regions.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/fillspots.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Handle Missing Values — fillspots","text":"list similarity network matrices missing spatial regions filled zero values.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/fillspots.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Handle Missing Values — fillspots","text":"function first identifies unique spatial regions across input list matrices. ensures matrix set regions adding missing regions zero similarity values. step crucial downstream analyses require consistent dimensions across samples.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/getColors.html","id":null,"dir":"Reference","previous_headings":"","what":"Generate a List of Colors — getColors","title":"Generate a List of Colors — getColors","text":"function generates list colors based specified number palette type. supports categorical continuous color palettes.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/getColors.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Generate a List of Colors — getColors","text":"","code":"getColors(n, palette = 1, categoric = TRUE, exclude = NULL)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/getColors.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Generate a List of Colors — getColors","text":"n integer specifying number colors required. palette integer specifying color palette use. categorical palettes, valid values 1 7, continuous palettes, valid values 1 14. categoric logical value indicating whether use categorical palettes (TRUE) continuous palettes (FALSE). Default TRUE. exclude character vector colors exclude generated list. Default NULL.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/getColors.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Generate a List of Colors — getColors","text":"vector colors.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/getColors.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Generate a List of Colors — getColors","text":"function uses different sets color palettes categorical continuous data. categorical data, function includes palettes kelly, cols25, polychrome, glasbey, alphabet2, alphabet. continuous data, function includes palettes like viridis, parula, magma, coolwarm, warmcool, inferno, plasma, several kovesi linear palettes. number requested colors exceeds available colors chosen palette, additional colors sampled combined set available colors, ensuring uniqueness generated colors. function uses `setdiff` exclude specified colors ensures colors repeated setting seed reproducibility.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/getColors.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Generate a List of Colors — getColors","text":"","code":"# Generate 5 categorical colors using the first palette getColors(5, palette = 1, categoric = TRUE) #> [1] \"#F3C300\" \"#875692\" \"#F38400\" \"#A1CAF1\" \"#222222\"  # Generate 10 continuous colors using the viridis palette getColors(10, palette = 1, categoric = FALSE) #>  [1] \"#440154\" \"#462777\" \"#3D4988\" \"#30678D\" \"#25818E\" \"#1F9D87\" \"#36B677\" #>  [8] \"#6DCC57\" \"#B3DC2B\" \"#FDE725\""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/matrixMultiply.html","id":null,"dir":"Reference","previous_headings":"","what":"Matrix Multiplication with Minibatching and Parallel Processing — matrixMultiply","title":"Matrix Multiplication with Minibatching and Parallel Processing — matrixMultiply","text":"function performs matrix multiplication two matrices (`mat1` `mat2`) using minibatching manage memory usage parallel processing speed computation. particularly useful large matrices full multiplication otherwise computationally intensive memory prohibitive.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/matrixMultiply.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Matrix Multiplication with Minibatching and Parallel Processing — matrixMultiply","text":"","code":"matrixMultiply(mat1, mat2, minibatch = 5000, ncores = 1)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/matrixMultiply.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Matrix Multiplication with Minibatching and Parallel Processing — matrixMultiply","text":"mat1 matrix dimensions (m x n). mat2 matrix dimensions (n x p). minibatch number columns `mat2` process minibatch. Default 5000. ncores number cores use parallel processing. Default 1 (parallel processing).","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/matrixMultiply.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Matrix Multiplication with Minibatching and Parallel Processing — matrixMultiply","text":"matrix dimensions (m x p) representing product `mat1` `mat2`.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/matrixMultiply.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Matrix Multiplication with Minibatching and Parallel Processing — matrixMultiply","text":"","code":"# Example usage: mat1 <- matrix(runif(1000), nrow=100, ncol=10) mat2 <- matrix(runif(2000), nrow=10, ncol=200) result <- matrixMultiply(mat1, mat2, minibatch=100, ncores=2)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/mostFrequent.html","id":null,"dir":"Reference","previous_headings":"","what":"Identify the most frequent category in a vector — mostFrequent","title":"Identify the most frequent category in a vector — mostFrequent","text":"function takes vector input returns frequent category value. works converting input table frequencies, sorting frequencies descending order, returning common value character string.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/mostFrequent.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Identify the most frequent category in a vector — mostFrequent","text":"","code":"mostFrequent(x)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/mostFrequent.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Identify the most frequent category in a vector — mostFrequent","text":"x vector values (e.g., categorical character data).","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/mostFrequent.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Identify the most frequent category in a vector — mostFrequent","text":"character string representing frequent value input vector.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/nmfClustering.html","id":null,"dir":"Reference","previous_headings":"","what":"Robust Clustering via NMF (non-negative matrix factorization) — nmfClustering","title":"Robust Clustering via NMF (non-negative matrix factorization) — nmfClustering","text":"one rank provided, NMF clustering performed. multiple ranks provided, function determine optimal number communities (K) assessing cophenetic coefficient across different values K.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/nmfClustering.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Robust Clustering via NMF (non-negative matrix factorization) — nmfClustering","text":"","code":"nmfClustering(   mat,   ranks = 10,   nrun.per.rank = 30,   min.coph = 0.95,   nmf.method = \"brunet\",   ncores = 1,   plot = FALSE,   seed = 2024,   ... )"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/nmfClustering.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Robust Clustering via NMF (non-negative matrix factorization) — nmfClustering","text":"mat Numeric matrix representing input data clustering analysis. ranks Numeric vector specifying number clusters evaluate. nrun.per.rank Integer specifying number runs per rank clustering. min.coph Numeric specifying minimum cophenetic coefficient required rank optimal. nmf.method Character string specifying method NMF analysis. ncores Integer specifying number CPU cores use parallel processing. plot Logical indicating whether plot results. seed integer used seed random number generator NMF analysis. ... Additional arguments passed nmf function.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/nmfClustering.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Robust Clustering via NMF (non-negative matrix factorization) — nmfClustering","text":"NMFfitX1 object one rank provided. list containing optimal number communities (bestK), list NMFfitX1 objects (NMFfits), ggplot object (p) displaying cophenetic coefficient across different values K.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/nmfClustering.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Robust Clustering via NMF (non-negative matrix factorization) — nmfClustering","text":"","code":"library(NMF) library(SpatialEcoTyper) mat <- matrix(rnorm(1000, 3), 20) mat[mat<0] = 0  ## Specify one rank result <- nmfClustering(mat = mat, ranks = 3, nrun.per.rank = 3) predict(result) #>  [1] 3 2 2 3 2 2 2 2 3 1 1 1 1 3 1 2 3 3 3 2 2 2 2 1 2 1 3 3 3 3 2 3 1 3 3 2 3 2 #> [39] 1 2 2 3 3 1 3 2 1 3 3 3 #> attr(,\"what\") #> [1] columns #> Levels: 1 2 3  ## Determine optimal ranks by testing multiple ranks result <- nmfClustering(mat = mat, ranks = 2:5, nrun.per.rank = 3) result$p  result$bestK #> [1] 2 predict(result$NMFfits[[paste0(\"K.\", result$bestK)]]) #>  [1] 1 1 2 1 1 1 1 1 2 2 2 2 1 2 2 1 1 2 2 1 1 1 2 2 1 2 1 2 1 1 1 2 2 2 1 1 2 1 #> [39] 2 1 2 1 1 2 2 1 2 2 2 2 #> attr(,\"what\") #> [1] columns #> Levels: 1 2"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/rankSparse.html","id":null,"dir":"Reference","previous_headings":"","what":"Transform a Sparse Matrix to Rank Space (Rank Non-zeros in Each Column) — rankSparse","title":"Transform a Sparse Matrix to Rank Space (Rank Non-zeros in Each Column) — rankSparse","text":"function ranks non-zero elements sparse matrix within column. ranks scaled dividing number rows matrix, resulting ranks normalized 0 1. original zero values left unchanged.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/rankSparse.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Transform a Sparse Matrix to Rank Space (Rank Non-zeros in Each Column) — rankSparse","text":"","code":"rankSparse(sparseMat)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/rankSparse.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Transform a Sparse Matrix to Rank Space (Rank Non-zeros in Each Column) — rankSparse","text":"sparseMat sparse matrix","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/rankSparse.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Transform a Sparse Matrix to Rank Space (Rank Non-zeros in Each Column) — rankSparse","text":"sparse matrix dimensions input, non-zero elements         replaced ranks within column, normalized number rows.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/rankSparse.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Transform a Sparse Matrix to Rank Space (Rank Non-zeros in Each Column) — rankSparse","text":"","code":"library(Matrix) # Create a sample sparse matrix sparseMat <- rsparsematrix(5, 5, density = 0.5) # Apply the ranking function rankedSparseMat <- rankSparse(sparseMat) print(rankedSparseMat) #> 5 x 5 sparse Matrix of class \"dgCMatrix\" #>                          #> [1,] 0.4 .   0.2 .   0.6 #> [2,] 0.6 .   0.4 .   .   #> [3,] 0.2 .   .   0.4 0.2 #> [4,] .   0.2 0.6 .   .   #> [5,] .   .   .   0.2 0.4"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/rank_sparse.html","id":null,"dir":"Reference","previous_headings":"","what":"Transform a sparse matrix to rank space (rank non-zeros in each column) — rank_sparse","title":"Transform a sparse matrix to rank space (rank non-zeros in each column) — rank_sparse","text":"function ranks non-zero elements sparse matrix within column. ranks scaled dividing number rows matrix, resulting ranks normalized 0 1. original zero values left unchanged.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/rank_sparse.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Transform a sparse matrix to rank space (rank non-zeros in each column) — rank_sparse","text":"","code":"rank_sparse(sparseMat)"},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/rank_sparse.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Transform a sparse matrix to rank space (rank non-zeros in each column) — rank_sparse","text":"sparseMat sparse matrix","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/rank_sparse.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Transform a sparse matrix to rank space (rank non-zeros in each column) — rank_sparse","text":"sparse matrix dimensions input, non-zero elements         replaced ranks within column, normalized number rows.","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/reference/rank_sparse.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Transform a sparse matrix to rank space (rank non-zeros in each column) — rank_sparse","text":"","code":"library(Matrix) # Create a sample sparse matrix sparseMat <- rsparsematrix(5, 5, density = 0.5) # Apply the ranking function rankedSparseMat <- rank_sparse(sparseMat) print(rankedSparseMat) #> 5 x 5 sparse Matrix of class \"dgCMatrix\" #>                          #> [1,] 0.4 .   0.2 .   0.6 #> [2,] 0.6 .   0.4 .   .   #> [3,] 0.2 .   .   0.4 0.2 #> [4,] .   0.2 0.6 .   .   #> [5,] .   .   .   0.2 0.4"},{"path":"https://digitalcytometry.github.io/spatialecotyper/news/index.html","id":"spatialecotyper-001","dir":"Changelog","previous_headings":"","what":"SpatialEcoTyper 0.0.1","title":"SpatialEcoTyper 0.0.1","text":"SpatialEcoTyper: SE discovery single sample MultiSpatialEcoTyper: Integrative analysis SEs multiple samples IntegrateSpatialEcoTyper: Integrative analysis SEs multiple samples RecoverSE: SE recovery nmfClustering: NMF clustering SpatialView: draw spatial map tissue HeatmapView: draw heatmap CreatePseudobulks: create pseudobulk mixtures NMFGenerateW: train NMF model SE deconvolution bulk expression profiles NMFGenerateWList: train cell-type specific NMF model SE recovery","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/news/index.html","id":"spatialecotyper-002","dir":"Changelog","previous_headings":"","what":"SpatialEcoTyper 0.0.2","title":"SpatialEcoTyper 0.0.2","text":"Reduce memory usage computing distance spatial neighbors pairwise distances","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/news/index.html","id":"spatialecotyper-003","dir":"Changelog","previous_headings":"","what":"SpatialEcoTyper 0.0.3","title":"SpatialEcoTyper 0.0.3","text":"Reduce memory usage replacing Reduce() loops Add seeds nmfClustering Re-organize documentation integrative analysis Test refine documentations","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/news/index.html","id":"spatialecotyper-004","dir":"Changelog","previous_headings":"","what":"SpatialEcoTyper 0.0.4","title":"SpatialEcoTyper 0.0.4","text":"Test Seurat v4.2, v4.4 v5 analysis add related notes: lead different embedding clustering results, show high consistency (ARI=0.7) demo. Add figures output directory integrative analysis Add hints training SE recovery model: demo less robust due limited number cells used. training data comprehensive possible. Add minibatch option SNF2 function reduce memory usage Add hints memory usage parallel processing","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/news/index.html","id":"spatialecotyper-005","dir":"Changelog","previous_headings":"","what":"SpatialEcoTyper 0.0.5","title":"SpatialEcoTyper 0.0.5","text":"Add filter.region..celltypes option SpatialEcoTyper MultiSpatialEcoTyper","code":""},{"path":"https://digitalcytometry.github.io/spatialecotyper/news/index.html","id":"spatialecotyper-100","dir":"Changelog","previous_headings":"","what":"SpatialEcoTyper 1.0.0","title":"SpatialEcoTyper 1.0.0","text":"First release","code":""}]
diff --git a/man/IntegrateSpatialEcoTyper.Rd b/man/IntegrateSpatialEcoTyper.Rd
index e41ea27..4e82f93 100644
--- a/man/IntegrateSpatialEcoTyper.Rd
+++ b/man/IntegrateSpatialEcoTyper.Rd
@@ -63,6 +63,6 @@ Default is 5000. This option splits the matrix into smaller chunks (minibatch),
 Integrate Multiple Spatial Transcriptomics Datasets to Identify Conserved Spatial Ecotypes
 }
 \examples{
-# See https://digitalcytometry.github.io/SpatialEcoTyper/docs/articles/Integration.html
+# See https://digitalcytometry.github.io/spatialecotyper/docs/articles/Integration.html
 
 }
diff --git a/man/MultiSpatialEcoTyper.Rd b/man/MultiSpatialEcoTyper.Rd
index 3c29b6c..6506d26 100644
--- a/man/MultiSpatialEcoTyper.Rd
+++ b/man/MultiSpatialEcoTyper.Rd
@@ -92,6 +92,6 @@ This function takes a list of gene expression matrices and corresponding metadat
          integrates the results across multiple samples to identify conserved spatial ecotypes.
 }
 \examples{
-# See https://digitalcytometry.github.io/SpatialEcoTyper/docs/articles/Integration.html
+# See https://digitalcytometry.github.io/spatialecotyper/docs/articles/Integration.html
 
 }
diff --git a/man/RecoverSE.Rd b/man/RecoverSE.Rd
index 1a4965e..b7e7384 100644
--- a/man/RecoverSE.Rd
+++ b/man/RecoverSE.Rd
@@ -32,7 +32,7 @@ Depending on the input data:
 This function can recover SEs from Visium, scRNA-seq data or single-cell spatial data.
 }
 \examples{
-# see https://digitalcytometry.github.io/SpatialEcoTyper_dev/articles/Recovery_scRNA.html
-# see https://digitalcytometry.github.io/SpatialEcoTyper_dev/articles/Recovery_Spatial.html
+# see https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_scRNA.html
+# see https://digitalcytometry.github.io/spatialecotyper/articles/Recovery_Spatial.html
 
 }
diff --git a/man/SpatialEcoTyper.Rd b/man/SpatialEcoTyper.Rd
index 740a42c..562b0d3 100644
--- a/man/SpatialEcoTyper.Rd
+++ b/man/SpatialEcoTyper.Rd
@@ -20,7 +20,7 @@ SpatialEcoTyper(
   iterations = 5,
   minibatch = 5000,
   ncores = 1,
-  binsize = round(radius * 1.4),
+  grid.size = round(radius * 1.4),
   filter.region.by.celltypes = NULL
 )
 }
@@ -60,8 +60,8 @@ Default is 5000. This option splits the matrix into smaller chunks (minibatch),
 
 \item{ncores}{Integer specifying the number of CPU cores to use for parallel processing.}
 
-\item{binsize}{Numeric specifying the bin size for spatial discretization of coordinates. By default,
-this size is determined based on the specified radius (radius*1.4 µm). Increasing the binsize will
+\item{grid.size}{Numeric specifying the grid size for spatial discretization of coordinates. By default,
+this size is determined based on the specified radius (radius*1.4 µm). Increasing the grid.size will
 downsample microregions and expedite the analysis, while it might eliminate cells located between bins
 from the SE discovery analysis.}
 
@@ -80,7 +80,7 @@ be included, regardless of cell type composition.
 This function identifies spatially distinct cellular ecosystems (SE) from a single sample.
 }
 \examples{
-# See https://digitalcytometry.github.io/SpatialEcoTyper/docs/articles/SingleSample.html
+# See https://digitalcytometry.github.io/spatialecotyper/docs/articles/SingleSample.html
 suppressPackageStartupMessages(library(dplyr))
 suppressPackageStartupMessages(library(ggplot2))
 suppressPackageStartupMessages(library(parallel))
diff --git a/vignettes/Integration.Rmd b/vignettes/Integration.Rmd
index ffa4b86..a06bcf5 100644
--- a/vignettes/Integration.Rmd
+++ b/vignettes/Integration.Rmd
@@ -314,7 +314,7 @@ IntegrateSpatialEcoTyper(SpatialEcoTyper_list, data_list,
 
Optimizing memory usage
 For real-world single-cell ST datasets with over 100,000 cells, the analysis can be both time- and memory-intensive. To speed up the process, you can increase the number of cores used (`ncores`), but this will also increase memory consumption.
 
-If you have limited computational memory, there are several strategies to reduce usage. One approach is to decrease the `minibatch` size and reduce the number of cores (`ncores`) allocated. However, for larger datasets, the minimum memory requirement may remain high. Another option is to increase the `binsize`, which reduces the number of spatial microregions. This can significantly decrease memory usage by downsampling the ST data, potentially excluding many cells from the analysis though.
+If you have limited computational memory, there are several strategies to reduce usage. One approach is to decrease the `minibatch` size and reduce the number of cores (`ncores`) allocated. However, for larger datasets, the minimum memory requirement may remain high. Another option is to increase the `grid.size`, which reduces the number of spatial microregions. This can significantly decrease memory usage by downsampling the ST data, potentially excluding many cells from the analysis though.
 
 

 
diff --git a/vignettes/SingleSample.Rmd b/vignettes/SingleSample.Rmd
index 887101c..57bb391 100644
--- a/vignettes/SingleSample.Rmd
+++ b/vignettes/SingleSample.Rmd
@@ -173,7 +173,7 @@ se_results <- SpatialEcoTyper(normdata, scmeta,
 
Optimizing memory usage
 For real-world single-cell ST datasets with over 100,000 cells, the analysis can be both time- and memory-intensive. To speed up the process, you can increase the number of cores used (`ncores`), but this will also increase memory consumption.
 
-If you have limited computational memory, there are several strategies to reduce usage. One approach is to decrease the `minibatch` size and reduce the number of cores (`ncores`) allocated. However, for larger datasets, the minimum memory requirement may remain high. Another option is to increase the `binsize`, which reduces the number of spatial microregions. This can significantly decrease memory usage by downsampling the ST data, potentially excluding many cells from the analysis though.
+If you have limited computational memory, there are several strategies to reduce usage. One approach is to decrease the `minibatch` size and reduce the number of cores (`ncores`) allocated. However, for larger datasets, the minimum memory requirement may remain high. Another option is to increase the `grid.size`, which reduces the number of spatial microregions. This can significantly decrease memory usage by downsampling the ST data, potentially excluding many cells from the analysis though.