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Output_real_run35b.lst
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10/05/2016
21:32
$PROBLEM GENTAMICIN model
;data from Nielsen2009, Thomson1988, Estonia_unpub
$INPUT ID GA GIRL TIME RATE EVID AMT WT CREAT DV PNA PMA TCREA OCC
;GA in weeks
;AMT in mg
;RATE in mg/h
;CREAT in umol/L
;PNA in days
;PMA in weeks
;WT in g
;TCREA = typical (for PMA) SCr: TCREA=PMA*(-2.8488)+166.48 [Cuzzolin 2006 and Rudd 1983]
;OCC=a dose with a subsequent level reported
$DATA C:\GENTAMICINeva\PKDatafiles\Gentamicin_22012016.csv IGNORE=@
$SUBROUTINE ADVAN6 TOL=6
$MODEL
COMP=(CENTRAL)
COMP=(PERIPH1)
COMP=(PERIPH2)
COMP=(COVCMT1) ; PNA time-var. covariate compartment
COMP=(COVCMT2) ; CREATININE t-v. cov. compartment
$PK
; Three-comp model
IF(NEWIND.NE.2)OTIM1=0
IF(NEWIND.NE.2)OCOV1=0
IF(NEWIND.NE.2)OTIM2=0
IF(NEWIND.NE.2)OCOV2=0
;
STUDY=0
IF(ID.LT.2000) STUDY=1 ;Glasgow, Thomson1988
IF(ID.GE.2000.AND.ID.LT.3000) STUDY=2 ;Uppsala, Nielsen2009
IF(ID.GE.3000) STUDY=3 ;Estonia, unpublished
;
WTKG = WT/1000
;
T50 = THETA(7)
HILL = THETA(8)
MF = PMA**HILL/(PMA**HILL+T50**HILL)
;
CREAT2 = CREAT
IF(CREAT.LT.0) CREAT2 = TCREA ; when SCr is NA=-99, it is the typical SCr
;OF = (CREAT2/TCREA)**(THETA(9))
;
P50 = THETA(10)
;PNAF = PNA/(P50+PNA)
;
CRPWR = THETA(9)
;IOV code
BOVC = 0
IF(OCC.EQ.1) BOVC = ETA(7)
IF(OCC.EQ.2) BOVC = ETA(8)
IF(OCC.EQ.3) BOVC = ETA(9)
IF(OCC.EQ.4) BOVC = ETA(10)
IF(OCC.EQ.5) BOVC = ETA(11)
IF(OCC.EQ.6) BOVC = ETA(12)
IF(OCC.EQ.7) BOVC = ETA(13)
IF(OCC.EQ.8) BOVC = ETA(14)
IF(OCC.EQ.9) BOVC = ETA(15)
IF(OCC.EQ.10) BOVC = ETA(16)
IF(OCC.EQ.11) BOVC = ETA(17)
IF(OCC.EQ.12) BOVC = ETA(18)
IF(OCC.EQ.13) BOVC = ETA(19)
IF(OCC.EQ.14) BOVC = ETA(20)
IF(OCC.EQ.15) BOVC = ETA(21)
IF(OCC.EQ.16) BOVC = ETA(22)
IF(OCC.EQ.17) BOVC = ETA(23)
IF(OCC.EQ.18) BOVC = ETA(24)
IF(OCC.EQ.19) BOVC = ETA(25)
IF(OCC.EQ.20) BOVC = ETA(26)
IF(OCC.EQ.21) BOVC = ETA(27)
IF(OCC.EQ.22) BOVC = ETA(28)
;
TVCL = THETA(1)*MF*(WTKG/70)**(0.632) ; typical value of CL
TVV1 = THETA(2)*(WTKG/70) ; typical value of V1
TVQ = THETA(3)*(WTKG/70)**(0.75) ; ty. value of intercompartmental CL
TVV2 = THETA(4)*(WTKG/70) ; ty. value of V2
TVQ2 = THETA(5)*(WTKG/70)**(0.75) ; ty value of CL3
TVV3 = THETA(6)*(WTKG/70) ; ty value of V3
;
CL = TVCL*EXP(ETA(1)+BOVC) ; individual value of CL
V1 = TVV1*EXP(ETA(2))
Q = TVQ*EXP(ETA(3))
V2 = TVV2*EXP(ETA(4))
Q2 = TVQ2*EXP(ETA(5))
V3 = TVV3*EXP(ETA(6))
;
K = CL/V1
K12 = Q/V1
K21 = Q/V2
K13 = Q2/V1
K31 = Q2/V3
;
IF(EVID.EQ.1) TM=TIME
IF(EVID.EQ.1) TAD=0
IF(EVID.NE.1) TAD=TIME-TM
;
SL1 = 0
IF(TIME.GT.OTIM1) SL1 = (PNA-OCOV1)/(TIME-OTIM1)
A_0(4) = PNA
;
SL2 = 0
IF(TIME.GT.OTIM2) SL2 = (CREAT2-OCOV2)/(TIME-OTIM2)
A_0(5) = CREAT2
;
$DES
DADT(4)= SL1
TCOV1 = A(4)
DADT(5)= SL2
TCOV2 = A(5)
;PNAF = PNA/(P50+PNA)
PNAF = TCOV1/(P50+TCOV1)
;OF = (CREAT2/TCREA)**(THETA(9))
OF = (TCOV2/TCREA)**CRPWR
DADT(1) = A(3)*K31+A(2)*K21-A(1)*(K*PNAF*OF+K12+K13)
DADT(2) = A(1)*K12-A(2)*K21
DADT(3) = A(1)*K13-A(3)*K31
$ERROR
IPRED = A(1)/V1
Y = IPRED*(1+EPS(1)) + EPS(2)
OCOV1 = PNA
OTIM1 = TIME
OCOV2 = CREAT2
OTIM2 = TIME
$THETA (0,6.20684) ; 1. TVCL (lower bound,initial estimate)
$THETA (0,26.5004) ; 2. TVV1 (lower bound,initial estimate)
$THETA (0,2.15099) ; 3. TVQ
$THETA (0,21.151) ; 4. TVV2
$THETA (0,0.270697) ; 5. TVQ2
$THETA (0,147.893) ; 6. TVV3
$THETA 55.4 FIX ; 7. T50
$THETA 3.33 FIX ; 8. Hill
$THETA -0.129934 ; 9. power exponent on creatinine
$THETA (0,1.70302) ; 10. PNA50
$OMEGA BLOCK(2)
0.175278 ; variance for ETA(1), initial estimate
0.115896 0.112362 ; COvariance ETA(1)-ETA(2), var for ETA(2), initial estimate
$OMEGA 0 FIX
$OMEGA 0.131759
$OMEGA 0 FIX
$OMEGA 0.177214
$OMEGA BLOCK(1)
0.0140684 ; 7. IOV_CL
$OMEGA BLOCK(1) SAME
$OMEGA BLOCK(1) SAME
$OMEGA BLOCK(1) SAME
$OMEGA BLOCK(1) SAME
$OMEGA BLOCK(1) SAME
$OMEGA BLOCK(1) SAME
$OMEGA BLOCK(1) SAME
$OMEGA BLOCK(1) SAME
$OMEGA BLOCK(1) SAME
$OMEGA BLOCK(1) SAME
$OMEGA BLOCK(1) SAME
$OMEGA BLOCK(1) SAME
$OMEGA BLOCK(1) SAME
$OMEGA BLOCK(1) SAME
$OMEGA BLOCK(1) SAME
$OMEGA BLOCK(1) SAME
$OMEGA BLOCK(1) SAME
$OMEGA BLOCK(1) SAME
$OMEGA BLOCK(1) SAME
$OMEGA BLOCK(1) SAME
$OMEGA BLOCK(1) SAME
$SIGMA 0.036033 ; variance PROP res error, initial estimate
$SIGMA 0.0164023
$ESTIMATION METHOD=1 INTER MAXEVAL=9999 PRINT=1 ; calculation method
$COVARIANCE ; standard error of estimate is calculated
$TABLE ID TIME IPRED DV CWRES
CL V1 Q V2 Q2 V3 ETA(1) ETA(2) ETA(3) ETA(4) ETA(5) ETA(6)
GA GIRL RATE EVID AMT WT CREAT PNA PMA TCREA OCC TAD STUDY
MF OF CREAT2 PNAF BOVC SL2 TCOV2 PNA SL1 TCOV1
TVCL TVV1 TVQ TVV2 TVQ2 TVV3 NOPRINT ONEHEADER FILE=sdtab35b
;$TABLE ID WT GA PNA PMA CREAT TCREA NOPRINT NOAPPEND ONEHEADER FILE=cotab32
;$TABLE ID GIRL STUDY NOPRINT NOAPPEND ONEHEADER FILE=catab32
;$TABLE ID CL V ETA(1) ETA(2) NOPRINT NOAPPEND ONEHEADER FILE=patab27
;$SCAT DV VS PRED UNIT
NM-TRAN MESSAGES
WARNINGS AND ERRORS (IF ANY) FOR PROBLEM 1
(WARNING 2) NM-TRAN INFERS THAT THE DATA ARE POPULATION.
(WARNING 48) DES-DEFINED ITEMS ARE COMPUTED ONLY WHEN EVENT TIME
INCREASES. E.G., DISPLAYED VALUES ASSOCIATED WITH THE FIRST EVENT RECORD
OF AN INDIVIDUAL RECORD ARE COMPUTED WITH (THE LAST ADVANCE TO) AN EVENT
TIME OF THE PRIOR INDIVIDUAL RECORD.
License Registered to: University of London
Expiration Date: 14 MAY 2016
Current Date: 10 MAY 2016
**** WARNING!!! Days until program expires : 4 ****
**** CONTACT idssoftware@iconplc.com FOR RENEWAL ****
1NONLINEAR MIXED EFFECTS MODEL PROGRAM (NONMEM) VERSION 7.3.0
ORIGINALLY DEVELOPED BY STUART BEAL, LEWIS SHEINER, AND ALISON BOECKMANN
CURRENT DEVELOPERS ARE ROBERT BAUER, ICON DEVELOPMENT SOLUTIONS,
AND ALISON BOECKMANN. IMPLEMENTATION, EFFICIENCY, AND STANDARDIZATION
PERFORMED BY NOUS INFOSYSTEMS.
PROBLEM NO.: 1
GENTAMICIN model
0DATA CHECKOUT RUN: NO
DATA SET LOCATED ON UNIT NO.: 2
THIS UNIT TO BE REWOUND: NO
NO. OF DATA RECS IN DATA SET: 2788
NO. OF DATA ITEMS IN DATA SET: 15
ID DATA ITEM IS DATA ITEM NO.: 1
DEP VARIABLE IS DATA ITEM NO.: 10
MDV DATA ITEM IS DATA ITEM NO.: 15
0INDICES PASSED TO SUBROUTINE PRED:
6 4 7 5 0 0 0 0 0 0 0
0LABELS FOR DATA ITEMS:
ID GA GIRL TIME RATE EVID AMT WT CREAT DV PNA PMA TCREA OCC MDV
0(NONBLANK) LABELS FOR PRED-DEFINED ITEMS:
STUDY MF CREAT2 BOVC TVCL TVV1 TVQ TVV2 TVQ2 TVV3 CL V1 Q V2 Q2 V3 TAD SL1 SL2 TCOV1 TCOV2 PNAF OF IPRED
0FORMAT FOR DATA:
(E4.0,E16.0,E1.0,2E11.0,E1.0,E4.0,E5.0,E3.0,2E5.0/2E11.0,E2.0,1F2.0)
TOT. NO. OF OBS RECS: 1325
TOT. NO. OF INDIVIDUALS: 205
0LENGTH OF THETA: 10
0DEFAULT THETA BOUNDARY TEST OMITTED: NO
0OMEGA HAS BLOCK FORM:
1
1 1
0 0 2
0 0 0 3
0 0 0 0 4
0 0 0 0 0 5
0 0 0 0 0 0 6
0 0 0 0 0 0 0 6
0 0 0 0 0 0 0 0 6
0 0 0 0 0 0 0 0 0 6
0 0 0 0 0 0 0 0 0 0 6
0 0 0 0 0 0 0 0 0 0 0 6
0 0 0 0 0 0 0 0 0 0 0 0 6
0 0 0 0 0 0 0 0 0 0 0 0 0 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6
0DEFAULT OMEGA BOUNDARY TEST OMITTED: NO
0SIGMA HAS SIMPLE DIAGONAL FORM WITH DIMENSION: 2
0DEFAULT SIGMA BOUNDARY TEST OMITTED: NO
0INITIAL ESTIMATE OF THETA:
LOWER BOUND INITIAL EST UPPER BOUND
0.0000E+00 0.6207E+01 0.1000E+07
0.0000E+00 0.2650E+02 0.1000E+07
0.0000E+00 0.2151E+01 0.1000E+07
0.0000E+00 0.2115E+02 0.1000E+07
0.0000E+00 0.2707E+00 0.1000E+07
0.0000E+00 0.1479E+03 0.1000E+07
0.5540E+02 0.5540E+02 0.5540E+02
0.3330E+01 0.3330E+01 0.3330E+01
-0.1000E+07 -0.1299E+00 0.1000E+07
0.0000E+00 0.1703E+01 0.1000E+07
0INITIAL ESTIMATE OF OMEGA:
BLOCK SET NO. BLOCK FIXED
1 NO
0.1753E+00
0.1159E+00 0.1124E+00
2 YES
0.0000E+00
3 NO
0.1318E+00
4 YES
0.0000E+00
5 NO
0.1772E+00
6 NO
0.1407E-01
0INITIAL ESTIMATE OF SIGMA:
0.3603E-01
0.0000E+00 0.1640E-01
0COVARIANCE STEP OMITTED: NO
EIGENVLS. PRINTED: NO
SPECIAL COMPUTATION: NO
COMPRESSED FORMAT: NO
SIGDIGITS ETAHAT (SIGLO): -1
SIGDIGITS GRADIENTS (SIGL): -1
RELATIVE TOLERANCE (TOL): -1
ABSOLUTE TOLERANCE-ADVAN 9,13 ONLY (ATOL): -1
EXCLUDE COV FOR FOCE (NOFCOV): NO
RESUME COV ANALYSIS (RESUME): NO
0TABLES STEP OMITTED: NO
NO. OF TABLES: 1
SEED NUMBER (SEED): 11456
RANMETHOD:
MC SAMPLES (ESEED): 300
WRES SQUARE ROOT TYPE: EIGENVALUE
0-- TABLE 1 --
PRINTED: NO
HEADERS: ONE
FILE TO BE FORWARDED: NO
FORMAT: S1PE11.4
LFORMAT:
RFORMAT:
0USER-CHOSEN ITEMS:
ID TIME IPRED DV CWRES CL V1 Q V2 Q2 V3 ETA1 ETA2 ETA3 ETA4 ETA5 ETA6 GA GIRL RATE EVID AMT WT CREAT PNA PMA TCREA OCC
TAD STUDY MF OF CREAT2 PNAF BOVC SL2 TCOV2 PNA SL1 TCOV1 TVCL TVV1 TVQ TVV2 TVQ2 TVV3
1DOUBLE PRECISION PREDPP VERSION 7.3.0
GENERAL NONLINEAR KINETICS MODEL (ADVAN6)
0MODEL SUBROUTINE USER-SUPPLIED - ID NO. 9999
0MAXIMUM NO. OF BASIC PK PARAMETERS: 9
0COMPARTMENT ATTRIBUTES
COMPT. NO. FUNCTION INITIAL ON/OFF DOSE DEFAULT DEFAULT
STATUS ALLOWED ALLOWED FOR DOSE FOR OBS.
1 CENTRAL ON YES YES YES YES
2 PERIPH1 ON YES YES NO NO
3 PERIPH2 ON YES YES NO NO
4 COVCMT1 ON YES YES NO NO
5 COVCMT2 ON YES YES NO NO
6 OUTPUT OFF YES NO NO NO
0NRD VALUE FROM SUBROUTINE TOL: 6
1
ADDITIONAL PK PARAMETERS - ASSIGNMENT OF ROWS IN GG
COMPT. NO. INDICES
SCALE BIOAVAIL. ZERO-ORDER ZERO-ORDER ABSORB
FRACTION RATE DURATION LAG
1 * * * * *
2 * * * * *
3 * * * * *
4 * * * * *
5 * * * * *
6 * - - - -
- PARAMETER IS NOT ALLOWED FOR THIS MODEL
* PARAMETER IS NOT SUPPLIED BY PK SUBROUTINE;
WILL DEFAULT TO ONE IF APPLICABLE
0DATA ITEM INDICES USED BY PRED ARE:
EVENT ID DATA ITEM IS DATA ITEM NO.: 6
TIME DATA ITEM IS DATA ITEM NO.: 4
DOSE AMOUNT DATA ITEM IS DATA ITEM NO.: 7
DOSE RATE DATA ITEM IS DATA ITEM NO.: 5
0PK SUBROUTINE CALLED WITH EVERY EVENT RECORD.
PK SUBROUTINE NOT CALLED AT NONEVENT (ADDITIONAL OR LAGGED) DOSE TIMES.
0PK SUBROUTINE INDICATES THAT COMPARTMENT AMOUNTS ARE INITIALIZED.
0ERROR SUBROUTINE CALLED WITH EVERY EVENT RECORD.
0ERROR SUBROUTINE INDICATES THAT DERIVATIVES OF COMPARTMENT AMOUNTS ARE USED.
0DES SUBROUTINE USES COMPACT STORAGE MODE.
1
#TBLN: 1
#METH: First Order Conditional Estimation with Interaction
ESTIMATION STEP OMITTED: NO
ANALYSIS TYPE: POPULATION
CONDITIONAL ESTIMATES USED: YES
CENTERED ETA: NO
EPS-ETA INTERACTION: YES
LAPLACIAN OBJ. FUNC.: NO
NO. OF FUNCT. EVALS. ALLOWED: 9999
NO. OF SIG. FIGURES REQUIRED: 3
INTERMEDIATE PRINTOUT: YES
ESTIMATE OUTPUT TO MSF: NO
IND. OBJ. FUNC. VALUES SORTED: NO
NUMERICAL DERIVATIVE
FILE REQUEST (NUMDER): NONE
MAP (ETAHAT) ESTIMATION METHOD (OPTMAP): 0
ETA HESSIAN EVALUATION METHOD (ETADER): 0
INITIAL ETA FOR MAP ESTIMATION (MCETA): 0
SIGDIGITS FOR MAP ESTIMATION (SIGLO): 100
GRADIENT SIGDIGITS OF
FIXED EFFECTS PARAMETERS (SIGL): 100
EXCLUDE TITLE (NOTITLE): NO
EXCLUDE COLUMN LABELS (NOLABEL): NO
NOPRIOR SETTING (NOPRIOR): OFF
NOCOV SETTING (NOCOV): OFF
DERCONT SETTING (DERCONT): OFF
ABSOLUTE TOLERANCE-ADVAN 9,13 ONLY(ATOL):-100
FINAL ETA RE-EVALUATION (FNLETA): ON
EXCLUDE NON-INFLUENTIAL (NON-INFL.) ETAS
IN SHRINKAGE (ETASTYPE): NO
NON-INFL. ETA CORRECTION (NONINFETA): OFF
FORMAT FOR ADDITIONAL FILES (FORMAT): S1PE12.5
PARAMETER ORDER FOR OUTPUTS (ORDER): TSOL
ADDITIONAL CONVERGENCE TEST (CTYPE=4)?: NO
EM OR BAYESIAN METHOD USED: NONE
THE FOLLOWING LABELS ARE EQUIVALENT
PRED=PREDI
RES=RESI
WRES=WRESI
IWRS=IWRESI
IPRD=IPREDI
IRS=IRESI
MONITORING OF SEARCH:
0ITERATION NO.: 0 OBJECTIVE VALUE: 1217.51929688863 NO. OF FUNC. EVALS.: 12
CUMULATIVE NO. OF FUNC. EVALS.: 12
NPARAMETR: 6.2068E+00 2.6500E+01 2.1510E+00 2.1151E+01 2.7070E-01 1.4789E+02 -1.2993E-01 1.7030E+00 1.7528E-01 1.1590E-01
1.1236E-01 1.3176E-01 1.7721E-01 1.4068E-02 3.6033E-02 1.6402E-02
PARAMETER: 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 -1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01
1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01
GRADIENT: 2.9002E+00 6.6052E-01 3.3614E-02 7.7759E-02 7.1152E-02 2.7071E-02 1.0282E+00 1.9702E-01 1.2458E-02 5.4351E-02
1.0053E-03 2.8209E-03 -1.2620E-04 9.7649E-04 2.2986E-01 1.1906E-02
0ITERATION NO.: 1 OBJECTIVE VALUE: 1217.51929688863 NO. OF FUNC. EVALS.: 28
CUMULATIVE NO. OF FUNC. EVALS.: 40
NPARAMETR: 6.2068E+00 2.6500E+01 2.1510E+00 2.1151E+01 2.7070E-01 1.4789E+02 -1.2993E-01 1.7030E+00 1.7528E-01 1.1590E-01
1.1236E-01 1.3176E-01 1.7721E-01 1.4068E-02 3.6033E-02 1.6402E-02
PARAMETER: 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 -1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01
1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01
GRADIENT: 9.3784E-04 -1.2335E-02 -5.5362E-03 -2.7962E-02 -1.5437E-02 3.5138E-03 -1.9973E-02 2.8888E-03 1.2458E-02 5.4351E-02
1.0053E-03 2.8209E-03 -1.2620E-04 9.7649E-04 7.3304E-03 1.8239E-03
0ITERATION NO.: 2 OBJECTIVE VALUE: 1217.51929688863 NO. OF FUNC. EVALS.: 38
CUMULATIVE NO. OF FUNC. EVALS.: 78
NPARAMETR: 6.2068E+00 2.6500E+01 2.1510E+00 2.1151E+01 2.7070E-01 1.4789E+02 -1.2993E-01 1.7030E+00 1.7528E-01 1.1590E-01
1.1236E-01 1.3176E-01 1.7721E-01 1.4068E-02 3.6033E-02 1.6402E-02
PARAMETER: 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 -1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01
1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01
GRADIENT: 4.2215E-04 -1.2656E-02 -5.6089E-03 -2.8062E-02 -1.5088E-02 1.2227E-03 -2.0012E-02 2.9740E-03 1.1687E-02 5.3376E-02
4.0319E-04 2.8093E-03 -6.0231E-04 1.7756E-03 8.0907E-03 2.0737E-03
#TERM:
0MINIMIZATION SUCCESSFUL
HOWEVER, PROBLEMS OCCURRED WITH THE MINIMIZATION.
REGARD THE RESULTS OF THE ESTIMATION STEP CAREFULLY, AND ACCEPT THEM ONLY
AFTER CHECKING THAT THE COVARIANCE STEP PRODUCES REASONABLE OUTPUT.
NO. OF FUNCTION EVALUATIONS USED: 78
NO. OF SIG. DIGITS IN FINAL EST.: 3.3
ETABAR IS THE ARITHMETIC MEAN OF THE ETA-ESTIMATES,
AND THE P-VALUE IS GIVEN FOR THE NULL HYPOTHESIS THAT THE TRUE MEAN IS 0.
ETABAR: 2.5281E-03 -3.6432E-03 0.0000E+00 -1.7276E-02 0.0000E+00 -7.2150E-03 -4.6273E-03 4.8876E-03 6.3720E-04 1.7133E-03
-1.1488E-03 8.1192E-05 -1.9639E-03 -2.2250E-04 7.9086E-05 5.7724E-04 -1.0254E-03 -8.5325E-04 6.1119E-04 1.6916E-04
1.1055E-03 1.4689E-04 3.8700E-04 2.4646E-04 9.4371E-05 1.9113E-05 6.2252E-04 4.9929E-05
SE: 2.7220E-02 1.9843E-02 0.0000E+00 1.0695E-02 0.0000E+00 4.4183E-03 3.1514E-03 2.6429E-03 2.2685E-03 1.4915E-03
1.5556E-03 1.5871E-03 1.2865E-03 1.0545E-03 1.6845E-03 1.6292E-03 1.1926E-03 7.9775E-04 3.1425E-04 4.2751E-04
7.6867E-04 2.3230E-04 5.8919E-04 3.8503E-04 4.9480E-04 1.9277E-05 4.4158E-04 5.2890E-05
N: 204 204 204 204 204 204 204 204 204 204
204 204 204 204 204 204 204 204 204 204
204 204 204 204 204 204 204 204
P VAL.: 9.2600E-01 8.5433E-01 1.0000E+00 1.0623E-01 1.0000E+00 1.0248E-01 1.4201E-01 6.4410E-02 7.7879E-01 2.5068E-01
4.6021E-01 9.5920E-01 1.2687E-01 8.3289E-01 9.6255E-01 7.2311E-01 3.8993E-01 2.8482E-01 5.1785E-02 6.9234E-01
1.5039E-01 5.2718E-01 5.1129E-01 5.2210E-01 8.4874E-01 3.2145E-01 1.5861E-01 3.4516E-01
ETAshrink(%): 6.9102E+00 1.5240E+01 1.0000E+02 5.7815E+01 1.0000E+02 8.4972E+01 6.1958E+01 6.8096E+01 7.2616E+01 8.1995E+01
8.1221E+01 8.0842E+01 8.4470E+01 8.7270E+01 7.9665E+01 8.0333E+01 8.5603E+01 9.0370E+01 9.6207E+01 9.4839E+01
9.0721E+01 9.7196E+01 9.2888E+01 9.5352E+01 9.4027E+01 9.9767E+01 9.4669E+01 9.9362E+01
EBVshrink(%): 6.7553E+00 1.5145E+01 0.0000E+00 5.7938E+01 0.0000E+00 8.5536E+01 6.3568E+01 6.9167E+01 7.1095E+01 7.6106E+01
7.8237E+01 8.2187E+01 8.3879E+01 8.4888E+01 8.5716E+01 8.8440E+01 8.9522E+01 9.0083E+01 9.1845E+01 9.0248E+01
9.2668E+01 9.3487E+01 9.2549E+01 9.4245E+01 9.5269E+01 9.8903E+01 9.4092E+01 9.6037E+01
EPSshrink(%): 1.5677E+01 1.5677E+01
#TERE:
Elapsed estimation time in seconds: 747.81
Elapsed covariance time in seconds: 3756.41
1
************************************************************************************************************************
******************** ********************
******************** FIRST ORDER CONDITIONAL ESTIMATION WITH INTERACTION ********************
#OBJT:************** MINIMUM VALUE OF OBJECTIVE FUNCTION ********************
******************** ********************
************************************************************************************************************************
#OBJV:******************************************** 1217.519 **************************************************
1
************************************************************************************************************************
******************** ********************
******************** FIRST ORDER CONDITIONAL ESTIMATION WITH INTERACTION ********************
******************** FINAL PARAMETER ESTIMATE ********************
******************** ********************
************************************************************************************************************************
THETA - VECTOR OF FIXED EFFECTS PARAMETERS *********
TH 1 TH 2 TH 3 TH 4 TH 5 TH 6 TH 7 TH 8 TH 9 TH10
6.21E+00 2.65E+01 2.15E+00 2.12E+01 2.71E-01 1.48E+02 5.54E+01 3.33E+00 -1.30E-01 1.70E+00
OMEGA - COV MATRIX FOR RANDOM EFFECTS - ETAS ********
ETA1 ETA2 ETA3 ETA4 ETA5 ETA6 ETA7 ETA8 ETA9 ET10 ET11 ET12
ET13 ET14 ET15 ET16 ET17 ET18 ET19 ET20 ET21 ET22 ET23 ET24
ET25 ET26 ET27 ET28
ETA1
+ 1.75E-01
ETA2
+ 1.16E-01 1.12E-01
ETA3
+ 0.00E+00 0.00E+00 0.00E+00
ETA4
+ 0.00E+00 0.00E+00 0.00E+00 1.32E-01
ETA5
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
ETA6
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 1.77E-01
ETA7
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 1.41E-02
ETA8
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 1.41E-02
ETA9
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 1.41E-02
ET10
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 1.41E-02
ET11
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 1.41E-02
ET12
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 1.41E-02
ET13
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
1.41E-02
ET14
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
0.00E+00 1.41E-02
ET15
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
0.00E+00 0.00E+00 1.41E-02
1
ETA1 ETA2 ETA3 ETA4 ETA5 ETA6 ETA7 ETA8 ETA9 ET10 ET11 ET12
ET13 ET14 ET15 ET16 ET17 ET18 ET19 ET20 ET21 ET22 ET23 ET24
ET25 ET26 ET27 ET28
ET16
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
0.00E+00 0.00E+00 0.00E+00 1.41E-02
ET17
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
0.00E+00 0.00E+00 0.00E+00 0.00E+00 1.41E-02
ET18
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 1.41E-02
ET19
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 1.41E-02
ET20
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 1.41E-02
ET21
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 1.41E-02
ET22
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 1.41E-02
ET23
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 1.41E-02
ET24
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 1.41E-02
ET25
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
1.41E-02
ET26
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
0.00E+00 1.41E-02
ET27
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
0.00E+00 0.00E+00 1.41E-02
ET28
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
0.00E+00 0.00E+00 0.00E+00 1.41E-02
SIGMA - COV MATRIX FOR RANDOM EFFECTS - EPSILONS ****
EPS1 EPS2
EPS1
+ 3.60E-02
1
EPS1 EPS2
EPS2
+ 0.00E+00 1.64E-02
1
OMEGA - CORR MATRIX FOR RANDOM EFFECTS - ETAS *******
ETA1 ETA2 ETA3 ETA4 ETA5 ETA6 ETA7 ETA8 ETA9 ET10 ET11 ET12
ET13 ET14 ET15 ET16 ET17 ET18 ET19 ET20 ET21 ET22 ET23 ET24
ET25 ET26 ET27 ET28
ETA1
+ 4.19E-01
ETA2
+ 8.26E-01 3.35E-01
ETA3
+ 0.00E+00 0.00E+00 0.00E+00
ETA4
+ 0.00E+00 0.00E+00 0.00E+00 3.63E-01
ETA5
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
ETA6
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 4.21E-01
ETA7
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 1.19E-01
ETA8
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 1.19E-01
ETA9
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 1.19E-01
ET10
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 1.19E-01
ET11
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 1.19E-01
ET12
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 1.19E-01
ET13
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
1.19E-01
ET14
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
0.00E+00 1.19E-01
ET15
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
0.00E+00 0.00E+00 1.19E-01
ET16
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
0.00E+00 0.00E+00 0.00E+00 1.19E-01
ET17
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
0.00E+00 0.00E+00 0.00E+00 0.00E+00 1.19E-01
ET18
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 1.19E-01
ET19
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 1.19E-01
1
ETA1 ETA2 ETA3 ETA4 ETA5 ETA6 ETA7 ETA8 ETA9 ET10 ET11 ET12
ET13 ET14 ET15 ET16 ET17 ET18 ET19 ET20 ET21 ET22 ET23 ET24
ET25 ET26 ET27 ET28
ET20
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 1.19E-01
ET21
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 1.19E-01
ET22
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 1.19E-01
ET23
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 1.19E-01
ET24
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 1.19E-01
ET25
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
1.19E-01
ET26
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
0.00E+00 1.19E-01
ET27
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
0.00E+00 0.00E+00 1.19E-01
ET28
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
0.00E+00 0.00E+00 0.00E+00 1.19E-01
SIGMA - CORR MATRIX FOR RANDOM EFFECTS - EPSILONS ***
EPS1 EPS2
EPS1
+ 1.90E-01
EPS2
+ 0.00E+00 1.28E-01
1
************************************************************************************************************************
******************** ********************
******************** FIRST ORDER CONDITIONAL ESTIMATION WITH INTERACTION ********************
******************** STANDARD ERROR OF ESTIMATE ********************
******************** ********************
************************************************************************************************************************
THETA - VECTOR OF FIXED EFFECTS PARAMETERS *********
TH 1 TH 2 TH 3 TH 4 TH 5 TH 6 TH 7 TH 8 TH 9 TH10
2.97E-01 1.06E+00 3.21E-01 1.69E+00 4.71E-02 5.08E+01 ......... ......... 5.56E-02 3.05E-01
OMEGA - COV MATRIX FOR RANDOM EFFECTS - ETAS ********
ETA1 ETA2 ETA3 ETA4 ETA5 ETA6 ETA7 ETA8 ETA9 ET10 ET11 ET12
ET13 ET14 ET15 ET16 ET17 ET18 ET19 ET20 ET21 ET22 ET23 ET24
ET25 ET26 ET27 ET28
ETA1
+ 3.81E-02
ETA2
+ 3.06E-02 3.21E-02
ETA3
+ ......... ......... .........
ETA4
+ ......... ......... ......... 5.90E-02
ETA5
+ ......... ......... ......... ......... .........
ETA6
+ ......... ......... ......... ......... ......... 2.29E-01
ETA7
+ ......... ......... ......... ......... ......... ......... 6.85E-03
ETA8
+ ......... ......... ......... ......... ......... ......... ......... .........
ETA9
+ ......... ......... ......... ......... ......... ......... ......... ......... .........
ET10
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
ET11
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
ET12
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
ET13
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
.........
ET14
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... .........
ET15
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... .........
1
ETA1 ETA2 ETA3 ETA4 ETA5 ETA6 ETA7 ETA8 ETA9 ET10 ET11 ET12
ET13 ET14 ET15 ET16 ET17 ET18 ET19 ET20 ET21 ET22 ET23 ET24
ET25 ET26 ET27 ET28
ET16
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... .........
ET17
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... .........
ET18
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... .........
ET19
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... .........
ET20
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... .........
ET21
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... .........
ET22
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... .........
ET23
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
ET24
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
ET25
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
.........
ET26
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... .........
ET27
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... .........
ET28
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... .........
SIGMA - COV MATRIX FOR RANDOM EFFECTS - EPSILONS ****
EPS1 EPS2
EPS1
+ 6.30E-03
1
EPS1 EPS2
EPS2
+ ......... 7.54E-03
1
OMEGA - CORR MATRIX FOR RANDOM EFFECTS - ETAS *******
ETA1 ETA2 ETA3 ETA4 ETA5 ETA6 ETA7 ETA8 ETA9 ET10 ET11 ET12
ET13 ET14 ET15 ET16 ET17 ET18 ET19 ET20 ET21 ET22 ET23 ET24
ET25 ET26 ET27 ET28
ETA1
+ 4.55E-02
ETA2
+ 1.12E-01 4.78E-02
ETA3
+ ......... ......... .........
ETA4
+ ......... ......... ......... 8.13E-02
ETA5
+ ......... ......... ......... ......... .........
ETA6
+ ......... ......... ......... ......... ......... 2.71E-01