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Output_real_merop_PK_run3.lst
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Pauline Thémans, Joseph J. Winkin, Flora T. Musuamba
Wed Sep 20 15:16:46 CEST 2017
;; 1. based on run1.mod
;; 2. Description: covariate model + WT on V2 + CPRED in pred3 ($TABLE)
;; x1. Author: user
$PROBLEM MEROPENEM IV INFUSION 3COMP DESCRIPTION PLASMA AND ELF
; CONCENTRATIONS FINAL COV MODEL
; ------------dataset------------
$INPUT ID AGE WT GFRC GFR DV TIME MDV CMT AMT RATE SS II EVID GRP
; WT [kg], GFRC [0: poor hepatic function, 1: good hepatic function],
; GFR [mL/min], DV [mg/L], TIME [h], CMT [1: plasma conc., 2: ELF conc],
; AMT (DOSE) [g], RATE (K) [g/h], II (T) [h], GRP=AMT/RATE (delta) [h]
; CL [L/h], V1 V2 V3 [L], Q2 Q3 [L/h], S1 S2 [L]
$DATA promessePK1.csv IGNORE=@
; ------------model------------
$SUBROUTINE ADVAN11 TRANS4
$PK
; parmacokinetic parameters
TVCL=THETA(1)*((GFR/65)**THETA(2)) ; CENTRAL
TVV1=THETA(3)*((WT/75)**THETA(4))
TVQ2=THETA(5) ; ELF
TVV2=THETA(6)*((WT/75)**THETA(9))
TVQ3=THETA(7) ; PERIPHERAL
TVV3=THETA(8)
; interindividual variance model
CL=TVCL*EXP(ETA(1))
V1=TVV1*EXP(ETA(2))
Q2=TVQ2
V2=TVV2*EXP(ETA(3))
Q3=TVQ3*EXP(ETA(4))
V3=TVV3
; scaling factor
S1=V1/1000 ; dose [g] and conc. [mg/L]
S2=V2/THETA(10)
$ERROR
; calcultate de result (i.e. model prediction)
H1=0
H2=0
IF(CMT.EQ.1) H1=1
IF(CMT.EQ.2) H2=1
Y=H1*(F*(1+EPS(1))+EPS(2))+H2*(F*(1+EPS(3))) ; +EPS(4)
W=F
IPRED=F ; prediction individuelle
IRES=DV-IPRED ; (individual-specific residual)
IWRES=IRES/W ; (individual-specific weighted residual)
; Initial estimates
$THETA (0,9.81355436018442) ; CL
$THETA 0.653109400662184 ; GFRCL
$THETA (0,4.53480721643241) ; V1
$THETA 1.12475365584077 ; WTV1
$THETA (0,11.7186301905937) ; Q2; ELF
$THETA (0,9.69726252224871) ; V2
$THETA (0,8.41511798967717) ; Q3; PERIPHERAL
$THETA (0,10.8162112974179) ; V3
$THETA 0.805863122538834 ; WTV2
$THETA 231.229833848399 ; V2/S2
$OMEGA BLOCK(4)
0.19808195049767 ; IIVCL
0 0.195893036337555 ; IIVV1
0 0 0.184676645216004 ; IIVV2
0 0 0 0.181094660002612 ; IIVQ3
$SIGMA 0.0198701414556805 ; epsPROP1
0.203004721167207 ; epsADD1
0.501989282726501 ; epsPROP2
$ESTIMATION METHOD=1 INTER MAXEVAL=9999 SIGDIGITS=3 POSTHOC PRINT=5 ; PRINT=1 ;
; precision des estimation? standard error of estimates & matrice de correlation
$COVARIANCE PRINT=E
$TABLE ID AGE WT GFRC GFR TIME MDV CMT RATE PRED CPRED RES WRES
IPRED IRES IWRES CWRES EVID NOPRINT FILE=pred3 ; population and individual predictions and residuals
$TABLE ID AGE WT GFRC GFR CL V1 Q2 V2 Q3 V3 ETA(1) ETA(2) ETA(3)
ETA(4) TVCL TVV1 TVQ2 TVV2 TVQ3 TVV3 NOPRINT NOAPPEND
FIRSTONLY FILE=param3 ; individual PK parameters (bayesiens,posthoc)
NM-TRAN MESSAGES
WARNINGS AND ERRORS (IF ANY) FOR PROBLEM 1
(WARNING 2) NM-TRAN INFERS THAT THE DATA ARE POPULATION.
License Registered to: INSERM UMR-S850
Expiration Date: 14 OCT 2017
Current Date: 20 SEP 2017
**** WARNING!!! Days until program expires : 24 ****
**** CONTACT idssoftware@iconplc.com FOR RENEWAL ****
1NONLINEAR MIXED EFFECTS MODEL PROGRAM (NONMEM) VERSION 7.3.0
ORIGINALLY DEVELOPED BY STUART BEAL, LEWIS SHEINER, AND ALISON BOECKMANN
CURRENT DEVELOPERS ARE ROBERT BAUER, ICON DEVELOPMENT SOLUTIONS,
AND ALISON BOECKMANN. IMPLEMENTATION, EFFICIENCY, AND STANDARDIZATION
PERFORMED BY NOUS INFOSYSTEMS.
PROBLEM NO.: 1
MEROPENEM IV INFUSION 3COMP DESCRIPTION PLASMA AND ELF
0DATA CHECKOUT RUN: NO
DATA SET LOCATED ON UNIT NO.: 2
THIS UNIT TO BE REWOUND: NO
NO. OF DATA RECS IN DATA SET: 899
NO. OF DATA ITEMS IN DATA SET: 15
ID DATA ITEM IS DATA ITEM NO.: 1
DEP VARIABLE IS DATA ITEM NO.: 6
MDV DATA ITEM IS DATA ITEM NO.: 8
0INDICES PASSED TO SUBROUTINE PRED:
14 7 10 11 12 13 9 0 0 0 0
0LABELS FOR DATA ITEMS:
ID AGE WT GFRC GFR DV TIME MDV CMT AMT RATE SS II EVID GRP
0(NONBLANK) LABELS FOR PRED-DEFINED ITEMS:
TVCL TVV1 TVQ2 TVV2 TVQ3 TVV3 CL V1 Q2 V2 Q3 V3 IPRED IRES IWRES
0FORMAT FOR DATA:
(2E3.0,E5.0,E2.0,2E6.0,E4.0,3E2.0,E12.0,3E2.0,E4.0)
TOT. NO. OF OBS RECS: 434
TOT. NO. OF INDIVIDUALS: 60
0LENGTH OF THETA: 10
0DEFAULT THETA BOUNDARY TEST OMITTED: NO
0OMEGA HAS BLOCK FORM:
1
1 1
1 1 1
1 1 1 1
0DEFAULT OMEGA BOUNDARY TEST OMITTED: NO
0SIGMA HAS SIMPLE DIAGONAL FORM WITH DIMENSION: 3
0DEFAULT SIGMA BOUNDARY TEST OMITTED: NO
0INITIAL ESTIMATE OF THETA:
LOWER BOUND INITIAL EST UPPER BOUND
0.0000E+00 0.9814E+01 0.1000E+07
-0.1000E+07 0.6531E+00 0.1000E+07
0.0000E+00 0.4535E+01 0.1000E+07
-0.1000E+07 0.1125E+01 0.1000E+07
0.0000E+00 0.1172E+02 0.1000E+07
0.0000E+00 0.9697E+01 0.1000E+07
0.0000E+00 0.8415E+01 0.1000E+07
0.0000E+00 0.1082E+02 0.1000E+07
-0.1000E+07 0.8059E+00 0.1000E+07
-0.1000E+07 0.2312E+03 0.1000E+07
0INITIAL ESTIMATE OF OMEGA:
BLOCK SET NO. BLOCK FIXED
1 NO
0.1981E+00
0.0000E+00 0.1959E+00
0.0000E+00 0.0000E+00 0.1847E+00
0.0000E+00 0.0000E+00 0.0000E+00 0.1811E+00
0INITIAL ESTIMATE OF SIGMA:
0.1987E-01
0.0000E+00 0.2030E+00
0.0000E+00 0.0000E+00 0.5020E+00
0COVARIANCE STEP OMITTED: NO
EIGENVLS. PRINTED: YES
SPECIAL COMPUTATION: NO
COMPRESSED FORMAT: NO
SIGDIGITS ETAHAT (SIGLO): -1
SIGDIGITS GRADIENTS (SIGL): -1
RELATIVE TOLERANCE (TOL): -1
ABSOLUTE TOLERANCE-ADVAN 9,13 ONLY (ATOL): -1
EXCLUDE COV FOR FOCE (NOFCOV): NO
RESUME COV ANALYSIS (RESUME): NO
0TABLES STEP OMITTED: NO
NO. OF TABLES: 2
SEED NUMBER (SEED): 11456
RANMETHOD:
MC SAMPLES (ESEED): 300
WRES SQUARE ROOT TYPE: EIGENVALUE
0-- TABLE 1 --
PRINTED: NO
HEADER: YES
FILE TO BE FORWARDED: NO
FORMAT: S1PE11.4
LFORMAT:
RFORMAT:
0USER-CHOSEN ITEMS:
ID AGE WT GFRC GFR TIME MDV CMT RATE CPRED IPRED IRES IWRES CWRES EVID
0-- TABLE 2 --
0FIRST RECORDS ONLY: YES
04 COLUMNS APPENDED: NO
PRINTED: NO
HEADER: YES
FILE TO BE FORWARDED: NO
FORMAT: S1PE11.4
LFORMAT:
RFORMAT:
0USER-CHOSEN ITEMS:
ID AGE WT GFRC GFR CL V1 Q2 V2 Q3 V3 ETA1 ETA2 ETA3 ETA4 TVCL TVV1 TVQ2 TVV2 TVQ3 TVV3
1DOUBLE PRECISION PREDPP VERSION 7.3.0
THREE COMPARTMENT MODEL (ADVAN11)
0MAXIMUM NO. OF BASIC PK PARAMETERS: 6
0BASIC PK PARAMETERS (AFTER TRANSLATION):
BASIC PK PARAMETER NO. 1: ELIMINATION RATE (K)
BASIC PK PARAMETER NO. 2: CENTRAL-TO-PERIPH1 RATE (K12)
BASIC PK PARAMETER NO. 3: PERIPH1-TO-CENTRAL RATE (K21)
BASIC PK PARAMETER NO. 4: CENTRAL-TO-PERIPH2 RATE (K13)
BASIC PK PARAMETER NO. 5: PERIPH2-TO-CENTRAL RATE (K31)
TRANSLATOR WILL CONVERT PARAMETERS
CL, V1, Q2, V2, Q3, V3 TO K, K12, K21, K13, K31 (TRANS4)
0COMPARTMENT ATTRIBUTES
COMPT. NO. FUNCTION INITIAL ON/OFF DOSE DEFAULT DEFAULT
STATUS ALLOWED ALLOWED FOR DOSE FOR OBS.
1 CENTRAL ON NO YES YES YES
2 PERIPH1 ON NO YES NO NO
3 PERIPH2 ON NO YES NO NO
4 OUTPUT OFF YES NO NO NO
1
ADDITIONAL PK PARAMETERS - ASSIGNMENT OF ROWS IN GG
COMPT. NO. INDICES
SCALE BIOAVAIL. ZERO-ORDER ZERO-ORDER ABSORB
FRACTION RATE DURATION LAG
1 7 * * * *
2 8 * * * *
3 * * * * *
4 * - - - -
- PARAMETER IS NOT ALLOWED FOR THIS MODEL
* PARAMETER IS NOT SUPPLIED BY PK SUBROUTINE;
WILL DEFAULT TO ONE IF APPLICABLE
0DATA ITEM INDICES USED BY PRED ARE:
EVENT ID DATA ITEM IS DATA ITEM NO.: 14
TIME DATA ITEM IS DATA ITEM NO.: 7
DOSE AMOUNT DATA ITEM IS DATA ITEM NO.: 10
DOSE RATE DATA ITEM IS DATA ITEM NO.: 11
STEADY STATE DATA ITEM IS DATA ITEM NO.: 12
INTERVAL DATA ITEM IS DATA ITEM NO.: 13
COMPT. NO. DATA ITEM IS DATA ITEM NO.: 9
0PK SUBROUTINE CALLED WITH EVERY EVENT RECORD.
PK SUBROUTINE NOT CALLED AT NONEVENT (ADDITIONAL OR LAGGED) DOSE TIMES.
0ERROR SUBROUTINE CALLED WITH EVERY EVENT RECORD.
1
#TBLN: 1
#METH: First Order Conditional Estimation with Interaction
ESTIMATION STEP OMITTED: NO
ANALYSIS TYPE: POPULATION
CONDITIONAL ESTIMATES USED: YES
CENTERED ETA: NO
EPS-ETA INTERACTION: YES
LAPLACIAN OBJ. FUNC.: NO
NO. OF FUNCT. EVALS. ALLOWED: 9999
NO. OF SIG. FIGURES REQUIRED: 3
INTERMEDIATE PRINTOUT: YES
ESTIMATE OUTPUT TO MSF: NO
IND. OBJ. FUNC. VALUES SORTED: NO
NUMERICAL DERIVATIVE
FILE REQUEST (NUMDER): NONE
MAP (ETAHAT) ESTIMATION METHOD (OPTMAP): 0
ETA HESSIAN EVALUATION METHOD (ETADER): 0
INITIAL ETA FOR MAP ESTIMATION (MCETA): 0
SIGDIGITS FOR MAP ESTIMATION (SIGLO): 100
GRADIENT SIGDIGITS OF
FIXED EFFECTS PARAMETERS (SIGL): 100
EXCLUDE TITLE (NOTITLE): NO
EXCLUDE COLUMN LABELS (NOLABEL): NO
NOPRIOR SETTING (NOPRIOR): OFF
NOCOV SETTING (NOCOV): OFF
DERCONT SETTING (DERCONT): OFF
ABSOLUTE TOLERANCE-ADVAN 9,13 ONLY(ATOL):-100
FINAL ETA RE-EVALUATION (FNLETA): ON
EXCLUDE NON-INFLUENTIAL (NON-INFL.) ETAS
IN SHRINKAGE (ETASTYPE): NO
NON-INFL. ETA CORRECTION (NONINFETA): OFF
FORMAT FOR ADDITIONAL FILES (FORMAT): S1PE12.5
PARAMETER ORDER FOR OUTPUTS (ORDER): TSOL
ADDITIONAL CONVERGENCE TEST (CTYPE=4)?: NO
EM OR BAYESIAN METHOD USED: NONE
THE FOLLOWING LABELS ARE EQUIVALENT
PRED=PREDI
RES=RESI
WRES=WRESI
IWRS=IWRESI
IPRD=IPREDI
IRS=IRESI
MONITORING OF SEARCH:
0ITERATION NO.: 0 OBJECTIVE VALUE: 1738.58359434343 NO. OF FUNC. EVALS.: 15
CUMULATIVE NO. OF FUNC. EVALS.: 15
NPARAMETR: 9.8136E+00 6.5311E-01 4.5348E+00 1.1248E+00 1.1719E+01 9.6973E+00 8.4151E+00 1.0816E+01 8.0586E-01 2.3123E+02
1.9808E-01 1.9589E-01 1.8468E-01 1.8109E-01 1.9870E-02 2.0300E-01 5.0199E-01
PARAMETER: 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01
1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01
GRADIENT: 1.3661E+02 -1.4090E+01 -3.0236E+02 -1.6238E+02 -1.3625E+02 9.6208E+01 -4.5161E+01 8.7814E+01 1.3391E+01 -1.8363E+02
1.3303E+01 -1.6539E+02 -7.4039E+01 -4.3807E+01 -2.5245E+02 -3.6096E+01 -6.1409E+00
0ITERATION NO.: 5 OBJECTIVE VALUE: 1549.36868944126 NO. OF FUNC. EVALS.: 16
CUMULATIVE NO. OF FUNC. EVALS.: 96
NPARAMETR: 7.8366E+00 6.5968E-01 7.5313E+00 1.4170E+00 1.5014E+01 8.2448E+00 9.2597E+00 9.0940E+00 5.1957E-01 2.2678E+02
1.6461E-01 2.9715E-01 2.4764E-01 2.1675E-01 3.0792E-02 2.1307E-01 4.9329E-01
PARAMETER: -1.2496E-01 1.0101E-01 6.0729E-01 1.2599E-01 3.4781E-01 -6.2259E-02 1.9564E-01 -7.3426E-02 6.4474E-02 9.8075E-02
7.4538E-03 3.0834E-01 2.4668E-01 1.8987E-01 3.1902E-01 1.2421E-01 9.1256E-02
GRADIENT: -6.5652E+00 -1.1308E+02 -8.1352E+01 -1.0258E+01 -2.4096E+01 2.0137E+01 2.1486E+01 -5.5433E+00 -1.6340E+01 -2.7865E+02
2.7640E+01 1.5107E+00 -2.7349E+01 -1.1867E+01 2.8159E+01 2.8132E+00 -8.4999E+00
0ITERATION NO.: 10 OBJECTIVE VALUE: 1509.66893466160 NO. OF FUNC. EVALS.: 16
CUMULATIVE NO. OF FUNC. EVALS.: 178
NPARAMETR: 7.8304E+00 6.9085E-01 1.2361E+01 7.1560E-01 1.8274E+01 6.3477E+00 6.9332E+00 1.0152E+01 3.7277E-01 2.3279E+02
1.1896E-01 2.3259E-01 4.8288E-01 2.5974E-01 2.1235E-02 3.0270E-01 4.6412E-01
PARAMETER: -1.2575E-01 1.0578E-01 1.1028E+00 6.3623E-02 5.4428E-01 -3.2375E-01 -9.3712E-02 3.6665E-02 4.6257E-02 1.0068E-01
-1.5496E-01 1.8586E-01 5.8058E-01 2.8032E-01 1.3321E-01 2.9975E-01 6.0784E-02
GRADIENT: -9.1319E+00 -6.1056E+01 2.3686E+01 -7.2447E+01 1.0431E+01 2.2332E+00 1.7334E+00 -1.4695E-01 1.1029E+01 -2.5444E+02
-1.0352E+01 8.0419E+00 -5.2270E+00 4.6738E+00 -3.0039E+01 -1.3833E+01 -1.2221E+01
0ITERATION NO.: 15 OBJECTIVE VALUE: 1501.93353430324 NO. OF FUNC. EVALS.: 16
CUMULATIVE NO. OF FUNC. EVALS.: 260
NPARAMETR: 7.7381E+00 7.0759E-01 1.2531E+01 5.5777E-01 1.0730E+01 4.4076E+00 8.6765E+00 1.0741E+01 2.8272E-01 2.2348E+02
1.0526E-01 1.1819E-01 1.8873E+00 2.0180E-01 2.5584E-02 2.1243E-01 4.5311E-01
PARAMETER: -1.3761E-01 1.0834E-01 1.1164E+00 4.9591E-02 1.1841E-02 -6.8852E-01 1.3058E-01 9.3027E-02 3.5083E-02 9.6647E-02
-2.1611E-01 -1.5262E-01 1.2621E+00 1.5414E-01 2.2637E-01 1.2268E-01 4.8774E-02
GRADIENT: -2.7898E+01 -2.2090E+01 -1.1830E+01 -1.5814E+02 2.5247E+01 -5.5191E-01 4.4056E+00 7.1183E+00 -1.0761E+01 -3.3785E+02
-2.2995E+01 -4.2995E+00 7.0272E+00 -3.0941E+00 7.0242E+00 1.8549E+00 -1.0038E+01
0ITERATION NO.: 20 OBJECTIVE VALUE: 1498.62642386179 NO. OF FUNC. EVALS.: 16
CUMULATIVE NO. OF FUNC. EVALS.: 344
NPARAMETR: 7.7083E+00 7.0241E-01 1.2086E+01 8.0709E-01 1.0399E+01 4.0335E+00 8.7346E+00 1.0681E+01 1.0236E-01 2.3907E+02
1.0834E-01 1.0771E-01 1.7619E+00 2.0067E-01 2.6480E-02 2.1557E-01 4.2325E-01
PARAMETER: -1.4147E-01 1.0755E-01 1.0803E+00 7.1757E-02 -1.9480E-02 -7.7721E-01 1.3726E-01 8.7462E-02 1.2702E-02 1.0339E-01
-2.0170E-01 -1.9906E-01 1.2278E+00 1.5132E-01 2.4359E-01 1.3004E-01 1.4690E-02
GRADIENT: -3.0443E+01 -4.1883E+01 -3.0202E+01 -8.8780E+01 1.9818E+01 -4.7268E+00 1.2613E+00 1.7657E+00 -1.1951E+01 -1.1047E+02
-1.8438E+01 -3.9846E+00 3.3616E+00 -2.7165E+00 1.9481E+01 4.3965E+00 -2.9120E+00
0ITERATION NO.: 25 OBJECTIVE VALUE: 1495.74717171090 NO. OF FUNC. EVALS.: 17
CUMULATIVE NO. OF FUNC. EVALS.: 427
NPARAMETR: 7.8613E+00 7.1235E-01 1.2841E+01 9.3566E-01 9.0312E+00 4.0309E+00 7.7743E+00 1.0186E+01 -7.5496E-01 2.3727E+02
1.1694E-01 1.0115E-01 1.9307E+00 1.6224E-01 2.5514E-02 2.4099E-01 4.2196E-01
PARAMETER: -1.2182E-01 1.0907E-01 1.1409E+00 8.3188E-02 -1.6049E-01 -7.7787E-01 2.0792E-02 3.9979E-02 -9.3683E-02 1.0261E-01
-1.6351E-01 -2.3047E-01 1.2735E+00 4.5034E-02 2.2500E-01 1.8576E-01 1.3164E-02
GRADIENT: -6.8258E+00 1.3459E+01 -1.9352E+01 -4.4480E+01 1.1208E+01 -2.8219E+00 -6.5504E+00 -1.6611E+00 -2.1599E+01 -1.4571E+02
-8.2311E+00 -7.4984E+00 2.2071E+00 -1.7622E+00 1.6529E+01 6.9737E+00 -4.7657E+00
0ITERATION NO.: 30 OBJECTIVE VALUE: 1488.81115969294 NO. OF FUNC. EVALS.: 16
CUMULATIVE NO. OF FUNC. EVALS.: 509
NPARAMETR: 7.9147E+00 7.0829E-01 1.3545E+01 9.4897E-01 6.6620E+00 4.0122E+00 8.3469E+00 1.0081E+01 1.0258E+00 2.4874E+02
1.2497E-01 1.4257E-01 1.8085E+00 1.9715E-01 2.3990E-02 2.0339E-01 4.0552E-01
PARAMETER: -1.1504E-01 1.0845E-01 1.1942E+00 8.4371E-02 -4.6475E-01 -7.8250E-01 9.1858E-02 2.9606E-02 1.2729E-01 1.0757E-01
-1.3029E-01 -5.8858E-02 1.2408E+00 1.4246E-01 1.9421E-01 1.0096E-01 -6.7065E-03
GRADIENT: -1.5327E+00 4.7501E+00 1.0531E+00 7.4858E-01 -8.2669E-02 -4.3058E-01 1.0639E+00 -2.8505E+00 -2.1256E-01 5.9833E+00
-1.0891E+00 1.0248E+00 3.0449E-01 5.2524E-01 -3.3878E-02 -4.6964E-01 4.0704E-01
0ITERATION NO.: 35 OBJECTIVE VALUE: 1488.78377295836 NO. OF FUNC. EVALS.: 30
CUMULATIVE NO. OF FUNC. EVALS.: 605
NPARAMETR: 7.9300E+00 7.0699E-01 1.3518E+01 9.4685E-01 6.6862E+00 4.0125E+00 8.2817E+00 1.0162E+01 1.0420E+00 2.4818E+02
1.2616E-01 1.3899E-01 1.7836E+00 1.8871E-01 2.4007E-02 2.0792E-01 4.0428E-01
PARAMETER: -1.1312E-01 1.0825E-01 1.1923E+00 8.4183E-02 -4.6114E-01 -7.8244E-01 8.4021E-02 3.7625E-02 1.2930E-01 1.0733E-01
-1.2557E-01 -7.1579E-02 1.2339E+00 1.2060E-01 1.9457E-01 1.1195E-01 -8.2337E-03
GRADIENT: -2.5791E+00 -4.8050E+01 -1.8510E+00 -7.3774E-01 -9.6520E-03 -3.0282E-01 -1.2810E-01 1.8088E-01 -4.3486E-02 -2.6866E+00
-1.7232E-02 -1.6209E-01 3.7177E-02 -2.7313E-02 -4.5818E-03 2.7130E-02 -2.8516E-02
0ITERATION NO.: 40 OBJECTIVE VALUE: 1488.72017258651 NO. OF FUNC. EVALS.: 30
CUMULATIVE NO. OF FUNC. EVALS.: 766
NPARAMETR: 7.9440E+00 7.2216E-01 1.3580E+01 9.4768E-01 6.6772E+00 4.0425E+00 8.2615E+00 1.0153E+01 1.0467E+00 2.4851E+02
1.2611E-01 1.3976E-01 1.7812E+00 1.8770E-01 2.4010E-02 2.0804E-01 4.0374E-01
PARAMETER: -1.1135E-01 1.1057E-01 1.1968E+00 8.4257E-02 -4.6248E-01 -7.7498E-01 8.1571E-02 3.6752E-02 1.2989E-01 1.0747E-01
-1.2577E-01 -6.8819E-02 1.2332E+00 1.1791E-01 1.9462E-01 1.1226E-01 -8.8996E-03
GRADIENT: -5.6730E-02 3.3227E-02 1.1528E-01 1.1927E-02 -1.4023E-01 6.4668E-03 2.6040E-02 3.0440E-01 7.0134E-03 -3.7565E-01
2.1035E-03 -1.3503E-02 5.6200E-02 -1.0876E-02 4.7416E-02 -3.8828E-03 -3.3408E-02
0ITERATION NO.: 45 OBJECTIVE VALUE: 1488.71882285967 NO. OF FUNC. EVALS.: 29
CUMULATIVE NO. OF FUNC. EVALS.: 911
NPARAMETR: 7.9443E+00 7.2229E-01 1.3575E+01 9.4887E-01 6.7262E+00 4.0831E+00 8.2224E+00 1.0111E+01 1.0422E+00 2.4861E+02
1.2607E-01 1.3984E-01 1.7642E+00 1.8687E-01 2.4005E-02 2.0768E-01 4.0411E-01
PARAMETER: -1.1131E-01 1.1059E-01 1.1964E+00 8.4363E-02 -4.5517E-01 -7.6499E-01 7.6830E-02 3.2619E-02 1.2932E-01 1.0752E-01
-1.2594E-01 -6.8529E-02 1.2284E+00 1.1568E-01 1.9451E-01 1.1140E-01 -8.4421E-03
GRADIENT: 2.8974E-02 5.7398E-01 2.9363E-02 5.4592E-02 -2.3236E-02 9.4901E-03 1.2531E-02 -3.0984E-02 -1.1342E-02 9.6042E-05
-4.6526E-03 -4.7417E-03 8.7208E-03 -9.9562E-04 2.2103E-03 -4.5365E-03 -7.2518E-03
0ITERATION NO.: 49 OBJECTIVE VALUE: 1488.71881768615 NO. OF FUNC. EVALS.: 26
CUMULATIVE NO. OF FUNC. EVALS.: 1024
NPARAMETR: 7.9442E+00 7.2230E-01 1.3574E+01 9.4875E-01 6.7272E+00 4.0827E+00 8.2226E+00 1.0112E+01 1.0427E+00 2.4861E+02
1.2607E-01 1.3985E-01 1.7640E+00 1.8689E-01 2.4004E-02 2.0771E-01 4.0414E-01
PARAMETER: -1.1133E-01 1.1059E-01 1.1964E+00 8.4351E-02 -4.5503E-01 -7.6508E-01 7.6857E-02 3.2667E-02 1.2939E-01 1.0752E-01
-1.2591E-01 -6.8483E-02 1.2284E+00 1.1576E-01 1.9451E-01 1.1147E-01 -8.4080E-03
GRADIENT: 2.0490E-02 5.7476E-01 2.2817E-02 5.0658E-03 -1.2589E-03 4.0248E-03 5.0516E-03 -4.2989E-04 -3.2902E-03 2.1580E-02
9.1708E-05 -1.5862E-04 1.6614E-03 8.3138E-04 3.7422E-03 1.1401E-03 -2.7890E-04
#TERM:
0MINIMIZATION SUCCESSFUL
NO. OF FUNCTION EVALUATIONS USED: 1024
NO. OF SIG. DIGITS IN FINAL EST.: 3.6
ETABAR IS THE ARITHMETIC MEAN OF THE ETA-ESTIMATES,
AND THE P-VALUE IS GIVEN FOR THE NULL HYPOTHESIS THAT THE TRUE MEAN IS 0.
ETABAR: 6.3073E-04 -2.0283E-02 7.4928E-02 -2.3915E-02
SE: 4.4990E-02 3.6884E-02 1.0978E-01 2.4700E-02
N: 60 60 60 60
P VAL.: 9.8881E-01 5.8238E-01 4.9490E-01 3.3293E-01
ETAshrink(%): 1.0245E+00 2.2959E+01 3.5435E+01 5.5370E+01
EBVshrink(%): 1.6812E+00 2.2836E+01 2.9898E+01 5.6298E+01
EPSshrink(%): 1.6924E+01 1.6924E+01 3.5124E+00
#TERE:
Elapsed estimation time in seconds: 14.83
Elapsed covariance time in seconds: 26.77
1
************************************************************************************************************************
******************** ********************
******************** FIRST ORDER CONDITIONAL ESTIMATION WITH INTERACTION ********************
#OBJT:************** MINIMUM VALUE OF OBJECTIVE FUNCTION ********************
******************** ********************
************************************************************************************************************************
#OBJV:******************************************** 1488.719 **************************************************
1
************************************************************************************************************************
******************** ********************
******************** FIRST ORDER CONDITIONAL ESTIMATION WITH INTERACTION ********************
******************** FINAL PARAMETER ESTIMATE ********************
******************** ********************
************************************************************************************************************************
THETA - VECTOR OF FIXED EFFECTS PARAMETERS *********
TH 1 TH 2 TH 3 TH 4 TH 5 TH 6 TH 7 TH 8 TH 9 TH10
7.94E+00 7.22E-01 1.36E+01 9.49E-01 6.73E+00 4.08E+00 8.22E+00 1.01E+01 1.04E+00 2.49E+02
OMEGA - COV MATRIX FOR RANDOM EFFECTS - ETAS ********
ETA1 ETA2 ETA3 ETA4
ETA1
+ 1.26E-01
ETA2
+ 0.00E+00 1.40E-01
ETA3
+ 0.00E+00 0.00E+00 1.76E+00
ETA4
+ 0.00E+00 0.00E+00 0.00E+00 1.87E-01
SIGMA - COV MATRIX FOR RANDOM EFFECTS - EPSILONS ****
EPS1 EPS2 EPS3
EPS1
+ 2.40E-02
EPS2
+ 0.00E+00 2.08E-01
EPS3
+ 0.00E+00 0.00E+00 4.04E-01
1
OMEGA - CORR MATRIX FOR RANDOM EFFECTS - ETAS *******
ETA1 ETA2 ETA3 ETA4
ETA1
+ 3.55E-01
ETA2
+ 0.00E+00 3.74E-01
ETA3
+ 0.00E+00 0.00E+00 1.33E+00
ETA4
+ 0.00E+00 0.00E+00 0.00E+00 4.32E-01
SIGMA - CORR MATRIX FOR RANDOM EFFECTS - EPSILONS ***
EPS1 EPS2 EPS3
EPS1
+ 1.55E-01
EPS2
+ 0.00E+00 4.56E-01
EPS3
+ 0.00E+00 0.00E+00 6.36E-01
1
************************************************************************************************************************
******************** ********************
******************** FIRST ORDER CONDITIONAL ESTIMATION WITH INTERACTION ********************
******************** STANDARD ERROR OF ESTIMATE ********************
******************** ********************
************************************************************************************************************************
THETA - VECTOR OF FIXED EFFECTS PARAMETERS *********
TH 1 TH 2 TH 3 TH 4 TH 5 TH 6 TH 7 TH 8 TH 9 TH10
3.93E-01 6.37E-02 8.51E-01 2.86E-01 1.23E+00 1.36E+00 1.50E+00 1.56E+00 1.19E+00 2.41E+01
OMEGA - COV MATRIX FOR RANDOM EFFECTS - ETAS ********
ETA1 ETA2 ETA3 ETA4
ETA1
+ 2.37E-02
ETA2
+ ......... 4.70E-02
ETA3
+ ......... ......... 7.23E-01
ETA4
+ ......... ......... ......... 1.05E-01
SIGMA - COV MATRIX FOR RANDOM EFFECTS - EPSILONS ****
EPS1 EPS2 EPS3
EPS1
+ 2.84E-03
EPS2
+ ......... 6.75E-02
EPS3
+ ......... ......... 8.60E-02
1
OMEGA - CORR MATRIX FOR RANDOM EFFECTS - ETAS *******
ETA1 ETA2 ETA3 ETA4
ETA1
+ 3.34E-02
ETA2
+ ......... 6.29E-02
ETA3
+ ......... ......... 2.72E-01
ETA4
+ ......... ......... ......... 1.22E-01
SIGMA - CORR MATRIX FOR RANDOM EFFECTS - EPSILONS ***
EPS1 EPS2 EPS3
EPS1
+ 9.15E-03
EPS2
+ ......... 7.41E-02
EPS3
+ ......... ......... 6.76E-02
1
************************************************************************************************************************
******************** ********************
******************** FIRST ORDER CONDITIONAL ESTIMATION WITH INTERACTION ********************
******************** COVARIANCE MATRIX OF ESTIMATE ********************
******************** ********************
************************************************************************************************************************
TH 1 TH 2 TH 3 TH 4 TH 5 TH 6 TH 7 TH 8 TH 9 TH10 OM11 OM12
OM13 OM14 OM22 OM23 OM24 OM33 OM34 OM44 SG11 SG12 SG13 SG22
SG23 SG33
TH 1
+ 1.55E-01
TH 2
+ -7.29E-03 4.05E-03
TH 3
+ 1.29E-01 6.24E-03 7.24E-01
TH 4
+ 2.97E-02 4.62E-03 2.09E-02 8.20E-02
TH 5
+ -3.04E-02 8.84E-03 6.66E-03 1.32E-01 1.51E+00
TH 6
+ -1.23E-01 -9.68E-03 7.08E-02 1.00E-02 1.17E+00 1.86E+00
TH 7
+ 1.02E-01 2.04E-03 -8.67E-02 7.59E-03 -1.24E+00 -1.44E+00 2.24E+00
TH 8
+ 9.91E-02 4.44E-04 5.03E-03 -2.91E-02 -1.60E+00 -1.55E+00 2.08E+00 2.43E+00
TH 9
+ 7.18E-02 -1.93E-02 1.61E-01 -7.43E-02 -2.06E-01 6.61E-02 -5.52E-01 -4.88E-01 1.41E+00
TH10
+ -7.91E-01 4.54E-01 -3.28E+00 1.02E+00 1.77E+00 -5.58E+00 -1.12E+00 1.73E+00 -7.15E+00 5.81E+02
OM11
+ -1.51E-03 3.30E-04 8.57E-04 -9.02E-05 -3.99E-03 -3.01E-03 5.23E-03 8.19E-03 -2.96E-03 1.90E-01 5.62E-04
OM12
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
OM13
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
.........
OM14
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... .........
OM22
+ 3.03E-03 -9.03E-05 1.31E-02 2.31E-03 -2.24E-02 -2.29E-02 2.66E-02 3.67E-02 3.79E-04 3.20E-02 2.44E-04 .........
......... ......... 2.21E-03
OM23
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... .........
OM24
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... .........
OM33
+ 7.34E-02 -6.95E-03 1.35E-01 -3.17E-03 -2.34E-01 -3.71E-01 3.67E-01 4.26E-01 2.31E-01 2.77E-01 4.98E-03 .........
......... ......... 1.41E-02 ......... ......... 5.23E-01
OM34
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... .........
1
TH 1 TH 2 TH 3 TH 4 TH 5 TH 6 TH 7 TH 8 TH 9 TH10 OM11 OM12
OM13 OM14 OM22 OM23 OM24 OM33 OM34 OM44 SG11 SG12 SG13 SG22
SG23 SG33
OM44
+ -4.40E-03 3.74E-04 -1.49E-02 6.82E-03 4.05E-02 1.58E-02 -3.38E-02 -4.67E-02 8.56E-03 2.66E-01 -3.07E-04 .........
......... ......... -4.78E-04 ......... ......... -3.16E-03 ......... 1.11E-02
SG11
+ 4.09E-04 1.49E-05 1.13E-03 1.31E-04 -7.60E-05 -1.18E-03 3.68E-04 3.00E-05 5.83E-04 -3.24E-03 -1.36E-05 .........
......... ......... 2.81E-05 ......... ......... 4.90E-04 ......... 4.51E-05 8.04E-06
SG12
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... .........
SG13
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
SG22
+ -7.78E-03 -1.21E-03 -1.89E-02 -6.45E-03 -7.42E-03 1.62E-02 -1.42E-02 -3.64E-03 -4.31E-03 1.85E-01 1.26E-04 .........
......... ......... -9.34E-04 ......... ......... -9.18E-03 ......... -1.87E-03 -9.34E-05 ......... ......... 4.56E-03
SG23
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
.........
SG33
+ 5.00E-03 6.03E-04 2.32E-02 1.43E-03 -2.09E-02 -2.60E-02 4.31E-02 4.38E-02 5.95E-03 -5.47E-01 2.83E-04 .........
......... ......... 2.19E-03 ......... ......... 2.66E-02 ......... -1.91E-03 3.38E-05 ......... ......... -1.76E-03
......... 7.39E-03
1
************************************************************************************************************************
******************** ********************
******************** FIRST ORDER CONDITIONAL ESTIMATION WITH INTERACTION ********************
******************** CORRELATION MATRIX OF ESTIMATE ********************
******************** ********************
************************************************************************************************************************
TH 1 TH 2 TH 3 TH 4 TH 5 TH 6 TH 7 TH 8 TH 9 TH10 OM11 OM12
OM13 OM14 OM22 OM23 OM24 OM33 OM34 OM44 SG11 SG12 SG13 SG22
SG23 SG33
TH 1
+ 3.93E-01
TH 2
+ -2.91E-01 6.37E-02
TH 3
+ 3.84E-01 1.15E-01 8.51E-01
TH 4
+ 2.64E-01 2.53E-01 8.56E-02 2.86E-01
TH 5
+ -6.30E-02 1.13E-01 6.37E-03 3.75E-01 1.23E+00
TH 6
+ -2.30E-01 -1.12E-01 6.10E-02 2.56E-02 6.97E-01 1.36E+00
TH 7
+ 1.72E-01 2.14E-02 -6.80E-02 1.77E-02 -6.74E-01 -7.06E-01 1.50E+00
TH 8
+ 1.62E-01 4.47E-03 3.79E-03 -6.51E-02 -8.35E-01 -7.31E-01 8.92E-01 1.56E+00
TH 9
+ 1.54E-01 -2.55E-01 1.59E-01 -2.19E-01 -1.41E-01 4.08E-02 -3.10E-01 -2.64E-01 1.19E+00
TH10
+ -8.35E-02 2.96E-01 -1.60E-01 1.47E-01 5.97E-02 -1.70E-01 -3.10E-02 4.59E-02 -2.50E-01 2.41E+01
OM11
+ -1.62E-01 2.19E-01 4.25E-02 -1.33E-02 -1.37E-01 -9.32E-02 1.47E-01 2.22E-01 -1.05E-01 3.33E-01 2.37E-02
OM12
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
OM13
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
.........
OM14
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... .........
OM22
+ 1.64E-01 -3.02E-02 3.26E-01 1.72E-01 -3.87E-01 -3.57E-01 3.77E-01 5.01E-01 6.79E-03 2.83E-02 2.18E-01 .........
......... ......... 4.70E-02
OM23
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... .........
OM24
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... .........
OM33
+ 2.58E-01 -1.51E-01 2.20E-01 -1.53E-02 -2.63E-01 -3.76E-01 3.39E-01 3.78E-01 2.69E-01 1.59E-02 2.90E-01 .........
......... ......... 4.14E-01 ......... ......... 7.23E-01
OM34
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... .........
1
TH 1 TH 2 TH 3 TH 4 TH 5 TH 6 TH 7 TH 8 TH 9 TH10 OM11 OM12
OM13 OM14 OM22 OM23 OM24 OM33 OM34 OM44 SG11 SG12 SG13 SG22
SG23 SG33
OM44
+ -1.06E-01 5.60E-02 -1.66E-01 2.27E-01 3.14E-01 1.10E-01 -2.15E-01 -2.85E-01 6.85E-02 1.05E-01 -1.23E-01 .........
......... ......... -9.66E-02 ......... ......... -4.15E-02 ......... 1.05E-01
SG11
+ 3.67E-01 8.27E-02 4.69E-01 1.62E-01 -2.18E-02 -3.06E-01 8.67E-02 6.77E-03 1.73E-01 -4.74E-02 -2.02E-01 .........
......... ......... 2.11E-01 ......... ......... 2.39E-01 ......... 1.51E-01 2.84E-03
SG12
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... .........
SG13
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
SG22
+ -2.93E-01 -2.81E-01 -3.29E-01 -3.33E-01 -8.94E-02 1.76E-01 -1.41E-01 -3.45E-02 -5.37E-02 1.14E-01 7.89E-02 .........
......... ......... -2.94E-01 ......... ......... -1.88E-01 ......... -2.64E-01 -4.88E-01 ......... ......... 6.75E-02
SG23
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
.........
SG33
+ 1.48E-01 1.10E-01 3.17E-01 5.82E-02 -1.98E-01 -2.22E-01 3.35E-01 3.27E-01 5.83E-02 -2.64E-01 1.39E-01 .........
......... ......... 5.41E-01 ......... ......... 4.28E-01 ......... -2.11E-01 1.39E-01 ......... ......... -3.04E-01
......... 8.60E-02
1
************************************************************************************************************************
******************** ********************
******************** FIRST ORDER CONDITIONAL ESTIMATION WITH INTERACTION ********************
******************** INVERSE COVARIANCE MATRIX OF ESTIMATE ********************
******************** ********************
************************************************************************************************************************
TH 1 TH 2 TH 3 TH 4 TH 5 TH 6 TH 7 TH 8 TH 9 TH10 OM11 OM12
OM13 OM14 OM22 OM23 OM24 OM33 OM34 OM44 SG11 SG12 SG13 SG22
SG23 SG33
TH 1
+ 1.65E+01
TH 2
+ 5.59E+01 6.15E+02
TH 3
+ -3.01E+00 -1.57E+01 3.46E+00
TH 4
+ -4.30E+00 -2.90E+01 1.02E+00 2.83E+01
TH 5
+ -4.93E+00 -1.40E+01 5.55E-01 -1.05E+01 1.48E+01
TH 6
+ 1.84E+00 1.14E+01 -1.12E+00 6.52E-01 -2.19E+00 2.46E+00
TH 7
+ 7.57E-01 5.89E+00 6.40E-01 5.88E-02 -1.67E+00 5.24E-01 3.38E+00
TH 8
+ -4.68E+00 -1.50E+01 -2.91E-01 -6.82E+00 1.21E+01 -6.70E-01 -3.94E+00 1.37E+01
TH 9
+ -2.54E+00 -4.53E+00 2.10E-01 -3.22E+00 6.17E+00 -4.62E-01 -2.37E-01 5.37E+00 3.86E+00
TH10
+ -3.53E-02 -4.19E-01 1.69E-02 1.14E-02 -1.55E-02 1.88E-02 1.93E-02 -8.64E-03 1.14E-02 3.21E-03
OM11
+ 1.20E+01 -2.31E+02 -1.00E+01 -7.94E+00 2.30E+01 -8.98E+00 -8.77E+00 1.95E+01 9.51E+00 -8.16E-01 2.83E+03
OM12
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
OM13
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
.........
OM14
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... .........
OM22
+ 4.03E+01 3.35E+02 -1.46E+01 -5.45E+01 3.15E+00 1.11E+00 1.56E+01 -2.65E+01 -2.47E+00 -4.41E-01 -1.78E+02 .........
......... ......... 1.21E+03
OM23
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... .........
OM24
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... .........
OM33
+ 2.17E+00 1.87E+01 -5.16E-01 3.73E+00 -6.02E+00 1.04E+00 5.57E-01 -5.35E+00 -3.22E+00 -1.29E-02 -4.10E+01 .........
......... ......... 3.67E+00 ......... ......... 6.31E+00
OM34
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... .........
1
TH 1 TH 2 TH 3 TH 4 TH 5 TH 6 TH 7 TH 8 TH 9 TH10 OM11 OM12
OM13 OM14 OM22 OM23 OM24 OM33 OM34 OM44 SG11 SG12 SG13 SG22
SG23 SG33
OM44
+ 1.04E+01 2.80E+01 3.78E+00 -4.21E+00 -7.24E+00 6.40E-01 1.67E+00 -4.97E+00 -3.61E+00 -4.28E-02 2.53E+01 .........
......... ......... -4.61E+00 ......... ......... 6.29E-01 ......... 1.38E+02
SG11
+ -1.38E+02 -3.16E+00 -4.61E+02 -1.92E+02 3.06E+02 2.95E+02 -2.11E+02 6.16E+02 1.47E+02 -7.60E-01 6.84E+03 .........
......... ......... -1.58E+03 ......... ......... -2.54E+02 ......... -8.98E+02 3.01E+05
SG12
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... .........
SG13
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
SG22
+ 2.04E+01 1.90E+02 5.26E-01 -2.18E+00 4.94E+00 -5.60E-01 6.83E+00 -4.25E+00 1.93E+00 -2.41E-01 -3.97E+01 .........
......... ......... 1.89E+02 ......... ......... 5.72E-01 ......... 7.21E+01 2.15E+03 ......... ......... 4.62E+02
SG23
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
.........
SG33
+ -2.19E+00 -1.11E+02 -1.23E+00 1.50E+01 -1.14E+01 1.31E+00 -3.90E+00 -3.70E+00 -4.04E+00 3.36E-01 2.47E+00 .........
......... ......... -2.65E+02 ......... ......... -6.16E+00 ......... 3.59E+01 9.06E+02 ......... ......... 9.83E+00
......... 3.00E+02
1
************************************************************************************************************************
******************** ********************
******************** FIRST ORDER CONDITIONAL ESTIMATION WITH INTERACTION ********************
******************** EIGENVALUES OF COR MATRIX OF ESTIMATE ********************
******************** ********************
************************************************************************************************************************
1 2 3 4 5 6 7 8 9 10 11 12
13 14 15 16 17
1.68E-02 9.50E-02 1.38E-01 1.82E-01 3.16E-01 3.64E-01 4.17E-01 5.17E-01 5.74E-01 6.25E-01 1.01E+00 1.07E+00
1.23E+00 1.44E+00 2.06E+00 2.64E+00 4.30E+00
#CPUT: Total CPU Time in Seconds, 41.701
Stop Time: