diff --git a/tests/src/test/java/org/eclipse/hono/tests/EnabledIfDnsRebindingIsSupported.java b/tests/src/test/java/org/eclipse/hono/tests/EnabledIfDnsRebindingIsSupported.java
new file mode 100644
index 0000000000..5540ccdae4
--- /dev/null
+++ b/tests/src/test/java/org/eclipse/hono/tests/EnabledIfDnsRebindingIsSupported.java
@@ -0,0 +1,41 @@
+/*******************************************************************************
+ * Copyright (c) 2022 Contributors to the Eclipse Foundation
+ *
+ * See the NOTICE file(s) distributed with this work for additional
+ * information regarding copyright ownership.
+ *
+ * This program and the accompanying materials are made available under the
+ * terms of the Eclipse Public License 2.0 which is available at
+ * http://www.eclipse.org/legal/epl-2.0
+ *
+ * SPDX-License-Identifier: EPL-2.0
+ *******************************************************************************/
+package org.eclipse.hono.tests;
+
+import java.lang.annotation.Retention;
+import java.lang.annotation.RetentionPolicy;
+
+import org.junit.jupiter.api.extension.ExtendWith;
+
+/**
+ * An annotation which configures a test to run only if DNS rebinding for the nip.io domain works in the
+ * local environment.
+ */
+@Retention(RetentionPolicy.RUNTIME)
+@ExtendWith(EnabledIfDnsRebindingIsSupportedCondition.class)
+public @interface EnabledIfDnsRebindingIsSupported {
+
+    /**
+     * The default domain name.
+     */
+    String DEFAULT_DOMAIN = "nip.io";
+
+    /**
+     * The domain to use for checking DNS rebinding to work.
+     * <p>
+     * The default value of this property is {@value #DEFAULT_DOMAIN}.
+     *
+     * @return The domain name.
+     */
+    String domain() default DEFAULT_DOMAIN;
+}
diff --git a/tests/src/test/java/org/eclipse/hono/tests/EnabledIfDnsRebindingIsSupportedCondition.java b/tests/src/test/java/org/eclipse/hono/tests/EnabledIfDnsRebindingIsSupportedCondition.java
new file mode 100644
index 0000000000..8887b267d6
--- /dev/null
+++ b/tests/src/test/java/org/eclipse/hono/tests/EnabledIfDnsRebindingIsSupportedCondition.java
@@ -0,0 +1,80 @@
+/**
+ * Copyright (c) 2022 Contributors to the Eclipse Foundation
+ *
+ * See the NOTICE file(s) distributed with this work for additional
+ * information regarding copyright ownership.
+ *
+ * This program and the accompanying materials are made available under the
+ * terms of the Eclipse Public License 2.0 which is available at
+ * http://www.eclipse.org/legal/epl-2.0
+ *
+ * SPDX-License-Identifier: EPL-2.0
+ */
+
+
+package org.eclipse.hono.tests;
+
+import java.net.InetAddress;
+import java.net.UnknownHostException;
+import java.util.HashMap;
+import java.util.Map;
+
+import org.junit.jupiter.api.extension.ConditionEvaluationResult;
+import org.junit.jupiter.api.extension.ExecutionCondition;
+import org.junit.jupiter.api.extension.ExtensionContext;
+import org.junit.platform.commons.util.AnnotationUtils;
+
+
+/**
+ * A condition that checks if DNS rebinding works for host names containing a particular domain.
+ * <p>
+ * This makes sure that a look up of a host name like {@code 127.0.0.1.nip.io} is successfully resolved to IPv4
+ * address {@code 127.0.0.1}.
+ * <p>
+ * The domain name to check is taken from {@link EnabledIfDnsRebindingIsSupported#domain()}.
+ */
+public class EnabledIfDnsRebindingIsSupportedCondition implements ExecutionCondition {
+
+    private static final Map<String, ConditionEvaluationResult> RESULTS = new HashMap<>();
+
+    /**
+     * Checks if {@code 127.0.0.1.nip.io} can be resolved to {@code 127.0.0.1}.
+     *
+     * @param context The context to evaluate in.
+     */
+    @Override
+    public ConditionEvaluationResult evaluateExecutionCondition(final ExtensionContext context) {
+
+        final String domainName = AnnotationUtils.findAnnotation(
+                context.getElement(),
+                EnabledIfDnsRebindingIsSupported.class)
+            .map(EnabledIfDnsRebindingIsSupported::domain)
+            .orElse(EnabledIfDnsRebindingIsSupported.DEFAULT_DOMAIN);
+
+        synchronized (RESULTS) {
+            return RESULTS.computeIfAbsent(domainName, this::performLookup);
+        }
+    }
+
+    private ConditionEvaluationResult performLookup(final String domainName) {
+
+
+        final String hostname = "127.0.0.1.%s".formatted(domainName);
+        try {
+            final var address = InetAddress.getByName(hostname);
+            if (address.isLoopbackAddress()) {
+                return ConditionEvaluationResult.enabled("lookup of %s succeeded".formatted(hostname));
+            } else {
+                return ConditionEvaluationResult.disabled("lookup of %s yields non-loopback address: %s"
+                        .formatted(hostname, address.getHostAddress()));
+            }
+        } catch (final UnknownHostException e) {
+            // DNS rebinding protection seems to be in place
+            return ConditionEvaluationResult.disabled("""
+                    DNS rebinding protection prevents resolving of %s. You might want to configure your resolver 
+                    to use a DNS server that allows rebinding for domain %s as described in 
+                    https://github.com/IBM-Blockchain/blockchain-vscode-extension/issues/2878#issuecomment-890147917
+                    """.formatted(hostname, domainName));
+        }
+    }
+}
diff --git a/tests/src/test/java/org/eclipse/hono/tests/IntegrationTestSupport.java b/tests/src/test/java/org/eclipse/hono/tests/IntegrationTestSupport.java
index 9f1b57dc20..a229055bea 100644
--- a/tests/src/test/java/org/eclipse/hono/tests/IntegrationTestSupport.java
+++ b/tests/src/test/java/org/eclipse/hono/tests/IntegrationTestSupport.java
@@ -37,6 +37,7 @@
 import java.util.OptionalInt;
 import java.util.Queue;
 import java.util.Set;
+import java.util.StringJoiner;
 import java.util.UUID;
 import java.util.concurrent.ExecutionException;
 import java.util.concurrent.TimeUnit;
@@ -383,7 +384,7 @@ public final class IntegrationTestSupport {
     /**
      * The IP address of the CoAP protocol adapter.
      */
-    public static final String COAP_HOST = IntegrationTestSupport.getResolvableHostname(PROPERTY_COAP_HOST);
+    public static final String COAP_HOST = System.getProperty(PROPERTY_COAP_HOST, DEFAULT_HOST);
     /**
      * The  port number that the CoAP adapter listens on for requests.
      */
@@ -395,7 +396,7 @@ public final class IntegrationTestSupport {
     /**
      * The IP address of the HTTP protocol adapter.
      */
-    public static final String HTTP_HOST = IntegrationTestSupport.getResolvableHostname(PROPERTY_HTTP_HOST);
+    public static final String HTTP_HOST = System.getProperty(PROPERTY_HTTP_HOST, DEFAULT_HOST);
     /**
      * The  port number that the HTTP adapter listens on for requests.
      */
@@ -407,7 +408,7 @@ public final class IntegrationTestSupport {
     /**
      * The IP address of the MQTT protocol adapter.
      */
-    public static final String MQTT_HOST = IntegrationTestSupport.getResolvableHostname(PROPERTY_MQTT_HOST);
+    public static final String MQTT_HOST = System.getProperty(PROPERTY_MQTT_HOST, DEFAULT_HOST);
     /**
      * The  port number that the MQTT adapter listens on for connections.
      */
@@ -419,7 +420,7 @@ public final class IntegrationTestSupport {
     /**
      * The IP address of the AMQP protocol adapter.
      */
-    public static final String AMQP_HOST = IntegrationTestSupport.getResolvableHostname(PROPERTY_AMQP_HOST);
+    public static final String AMQP_HOST = System.getProperty(PROPERTY_AMQP_HOST, DEFAULT_HOST);
     /**
      * The  port number that the AMQP adapter listens on for connections.
      */
@@ -531,16 +532,20 @@ public IntegrationTestSupport(final Vertx vertx) {
     }
 
     /**
-     * Gets a host name/IP address that can be resolved via DNS from the value of a Java system property.
+     * Gets a host name in the {@code nip.io} domain for a given host name.
      *
-     * @param systemPropertyName The name of the property to read.
+     * @param hostname The host name.
+     * @param virtualHost The virtual host name to prepend.
      * @return The host name.
      */
-    private static String getResolvableHostname(final String systemPropertyName) {
-        return Optional.of(System.getProperty(systemPropertyName, DEFAULT_HOST))
-                .map(host -> "localhost".equals(host) ? DEFAULT_HOST : host)
-                .map(ipAddress -> ipAddress + ".nip.io")
-                .get();
+    public static String getSniHostname(final String hostname, final String virtualHost) {
+
+        Objects.requireNonNull(hostname);
+        final String literalIpAddress = "localhost".equals(hostname) ? DEFAULT_HOST : hostname;
+        final var b = new StringJoiner(".");
+        Optional.ofNullable(virtualHost).ifPresent(b::add);
+        b.add(literalIpAddress).add("nip.io");
+        return b.toString();
     }
 
     private static ClientConfigProperties getClientConfigProperties(
diff --git a/tests/src/test/java/org/eclipse/hono/tests/amqp/AmqpConnectionIT.java b/tests/src/test/java/org/eclipse/hono/tests/amqp/AmqpConnectionIT.java
index b4b7af3629..12c1ded8d6 100644
--- a/tests/src/test/java/org/eclipse/hono/tests/amqp/AmqpConnectionIT.java
+++ b/tests/src/test/java/org/eclipse/hono/tests/amqp/AmqpConnectionIT.java
@@ -28,6 +28,7 @@
 
 import org.eclipse.hono.client.ClientErrorException;
 import org.eclipse.hono.service.management.tenant.Tenant;
+import org.eclipse.hono.tests.EnabledIfDnsRebindingIsSupported;
 import org.eclipse.hono.tests.EnabledIfRegistrySupportsFeatures;
 import org.eclipse.hono.tests.IntegrationTestSupport;
 import org.eclipse.hono.tests.Tenants;
@@ -153,6 +154,7 @@ public void testConnectX509SucceedsForRegisteredDevice(final String tlsVersion,
      */
     @ParameterizedTest(name = IntegrationTestSupport.PARAMETERIZED_TEST_NAME_PATTERN)
     @ValueSource(strings = { IntegrationTestSupport.TLS_VERSION_1_2, IntegrationTestSupport.TLS_VERSION_1_3 })
+    @EnabledIfDnsRebindingIsSupported
     @EnabledIfRegistrySupportsFeatures(trustAnchorGroups = true)
     public void testConnectX509SucceedsUsingSni(final String tlsVersion, final VertxTestContext ctx) {
 
@@ -171,7 +173,7 @@ public void testConnectX509SucceedsUsingSni(final String tlsVersion, final Vertx
                     deviceId,
                     cert))
             .compose(ok -> connectToAdapter(
-                    tenantId + "." + IntegrationTestSupport.AMQP_HOST,
+                    IntegrationTestSupport.getSniHostname(IntegrationTestSupport.AMQP_HOST, tenantId),
                     deviceCert,
                     tlsVersion))
             .onComplete(ctx.succeeding(con -> {
@@ -189,6 +191,7 @@ public void testConnectX509SucceedsUsingSni(final String tlsVersion, final Vertx
      */
     @ParameterizedTest(name = IntegrationTestSupport.PARAMETERIZED_TEST_NAME_PATTERN)
     @ValueSource(strings = { IntegrationTestSupport.TLS_VERSION_1_2, IntegrationTestSupport.TLS_VERSION_1_3 })
+    @EnabledIfDnsRebindingIsSupported
     @EnabledIfRegistrySupportsFeatures(trustAnchorGroups = true, tenantAlias = true)
     public void testConnectX509SucceedsUsingSniWithTenantAlias(final String tlsVersion, final VertxTestContext ctx) {
 
@@ -209,7 +212,7 @@ public void testConnectX509SucceedsUsingSniWithTenantAlias(final String tlsVersi
                     deviceId,
                     cert))
             .compose(ok -> connectToAdapter(
-                    "test-alias." + IntegrationTestSupport.AMQP_HOST,
+                    IntegrationTestSupport.getSniHostname(IntegrationTestSupport.AMQP_HOST, "test-alias"),
                     deviceCert,
                     tlsVersion))
             .onComplete(ctx.succeeding(con -> {
@@ -620,6 +623,7 @@ public void testConnectFailsForNonMatchingTrustAnchor(final VertxTestContext ctx
      * @param ctx The test context
      */
     @Test
+    @EnabledIfDnsRebindingIsSupported
     @EnabledIfRegistrySupportsFeatures(trustAnchorGroups = true, tenantAlias = true)
     public void testConnectX509FailsUsingSniWithNonExistingTenantAlias(final VertxTestContext ctx) {
 
@@ -640,7 +644,7 @@ public void testConnectX509FailsUsingSniWithNonExistingTenantAlias(final VertxTe
                     deviceId,
                     cert))
             .compose(ok -> connectToAdapter(
-                    "wrong-alias." + IntegrationTestSupport.AMQP_HOST,
+                    IntegrationTestSupport.getSniHostname(IntegrationTestSupport.AMQP_HOST, "wrong-alias"),
                     deviceCert,
                     IntegrationTestSupport.TLS_VERSION_1_2))
             .onComplete(ctx.failing(t -> {
diff --git a/tests/src/test/java/org/eclipse/hono/tests/coap/TelemetryCoapIT.java b/tests/src/test/java/org/eclipse/hono/tests/coap/TelemetryCoapIT.java
index a79951bcde..501a80a6dc 100644
--- a/tests/src/test/java/org/eclipse/hono/tests/coap/TelemetryCoapIT.java
+++ b/tests/src/test/java/org/eclipse/hono/tests/coap/TelemetryCoapIT.java
@@ -32,6 +32,7 @@
 import org.eclipse.hono.application.client.MessageContext;
 import org.eclipse.hono.config.KeyLoader;
 import org.eclipse.hono.service.management.tenant.Tenant;
+import org.eclipse.hono.tests.EnabledIfDnsRebindingIsSupported;
 import org.eclipse.hono.tests.EnabledIfRegistrySupportsFeatures;
 import org.eclipse.hono.tests.IntegrationTestSupport;
 import org.eclipse.hono.tests.Tenants;
@@ -180,6 +181,7 @@ public void testRootResourceDoesNotExposeAnyInfo(final VertxTestContext ctx) thr
      * @throws InterruptedException if the test fails.
      */
     @Test
+    @EnabledIfDnsRebindingIsSupported
     @EnabledIfRegistrySupportsFeatures(trustAnchorGroups = true, tenantAlias = true)
     public void testUploadMessagesUsingClientCertificateWithAlias(final VertxTestContext ctx) throws InterruptedException {
 
@@ -212,11 +214,13 @@ public void testUploadMessagesUsingClientCertificateWithAlias(final VertxTestCon
 
         final CoapClient client = getCoapsClient(clientCertLoader);
 
+        final var hostname = IntegrationTestSupport.getSniHostname(IntegrationTestSupport.COAP_HOST, "test-alias");
+
         testUploadMessages(ctx, tenantId,
                 () -> warmUp(client, createCoapsRequest(
                         Code.POST,
                         getMessageType(),
-                        "test-alias." + IntegrationTestSupport.COAP_HOST,
+                        hostname,
                         getPostResource(),
                         "hello 0".getBytes(StandardCharsets.UTF_8))),
                 count -> {
@@ -225,7 +229,7 @@ public void testUploadMessagesUsingClientCertificateWithAlias(final VertxTestCon
                     final Request request = createCoapsRequest(
                             Code.POST,
                             getMessageType(),
-                            "test-alias." + IntegrationTestSupport.COAP_HOST,
+                            hostname,
                             getPostResource(),
                             payload.getBytes(StandardCharsets.UTF_8));
                     client.advanced(getHandler(result), request);
diff --git a/tests/src/test/java/org/eclipse/hono/tests/http/TelemetryHttpIT.java b/tests/src/test/java/org/eclipse/hono/tests/http/TelemetryHttpIT.java
index 9ca198a84d..6357b61225 100644
--- a/tests/src/test/java/org/eclipse/hono/tests/http/TelemetryHttpIT.java
+++ b/tests/src/test/java/org/eclipse/hono/tests/http/TelemetryHttpIT.java
@@ -29,6 +29,7 @@
 import org.eclipse.hono.client.ServiceInvocationException;
 import org.eclipse.hono.service.management.tenant.Tenant;
 import org.eclipse.hono.tests.AssumeMessagingSystem;
+import org.eclipse.hono.tests.EnabledIfDnsRebindingIsSupported;
 import org.eclipse.hono.tests.EnabledIfRegistrySupportsFeatures;
 import org.eclipse.hono.tests.IntegrationTestSupport;
 import org.eclipse.hono.tests.Tenants;
@@ -297,6 +298,7 @@ public void testUploadQos1MessageFailsIfDeliveryStateNotUpdated(
      * @throws InterruptedException if the test fails.
      */
     @Test
+    @EnabledIfDnsRebindingIsSupported
     @EnabledIfRegistrySupportsFeatures(trustAnchorGroups = true, tenantAlias = true)
     public void testUploadMessagesUsingClientCertificateWithAlias(final VertxTestContext ctx) throws InterruptedException {
 
@@ -326,7 +328,7 @@ public void testUploadMessagesUsingClientCertificateWithAlias(final VertxTestCon
         }
 
         final RequestOptions options = new RequestOptions()
-                .setHost("test-alias." + IntegrationTestSupport.HTTP_HOST)
+                .setHost(IntegrationTestSupport.getSniHostname(IntegrationTestSupport.HTTP_HOST, "test-alias"))
                 .setPort(IntegrationTestSupport.HTTPS_PORT)
                 .setURI(getEndpointUri())
                 .setHeaders(requestHeaders);
diff --git a/tests/src/test/java/org/eclipse/hono/tests/mqtt/MqttConnectionIT.java b/tests/src/test/java/org/eclipse/hono/tests/mqtt/MqttConnectionIT.java
index 237aabeb9a..ac5f48c86a 100644
--- a/tests/src/test/java/org/eclipse/hono/tests/mqtt/MqttConnectionIT.java
+++ b/tests/src/test/java/org/eclipse/hono/tests/mqtt/MqttConnectionIT.java
@@ -29,6 +29,7 @@
 import org.eclipse.hono.service.management.credentials.X509CertificateSecret;
 import org.eclipse.hono.service.management.device.Device;
 import org.eclipse.hono.service.management.tenant.Tenant;
+import org.eclipse.hono.tests.EnabledIfDnsRebindingIsSupported;
 import org.eclipse.hono.tests.EnabledIfRegistrySupportsFeatures;
 import org.eclipse.hono.tests.IntegrationTestSupport;
 import org.eclipse.hono.tests.Tenants;
@@ -126,6 +127,7 @@ public void testConnectX509SucceedsForRegisteredDevice(final VertxTestContext ct
      * @param ctx The test context
      */
     @Test
+    @EnabledIfDnsRebindingIsSupported
     @EnabledIfRegistrySupportsFeatures(trustAnchorGroups = true)
     public void testConnectX509SucceedsUsingSni(final VertxTestContext ctx) {
 
@@ -140,7 +142,9 @@ public void testConnectX509SucceedsUsingSni(final VertxTestContext ctx) {
                         .compose(ok -> helper.registry.addDeviceForTenant(tenantId, tenant, deviceId, cert));
             })
             // WHEN the device connects to the adapter including its tenant ID in the host name
-            .compose(ok -> connectToAdapter(deviceCert, tenantId + "." + IntegrationTestSupport.MQTT_HOST))
+            .compose(ok -> connectToAdapter(
+                    deviceCert,
+                    IntegrationTestSupport.getSniHostname(IntegrationTestSupport.MQTT_HOST, tenantId)))
             .onComplete(ctx.succeeding(conAckMsg -> {
                 // THEN the connection attempt succeeds
                 ctx.verify(() -> assertThat(conAckMsg.code()).isEqualTo(MqttConnectReturnCode.CONNECTION_ACCEPTED));
@@ -155,6 +159,7 @@ public void testConnectX509SucceedsUsingSni(final VertxTestContext ctx) {
      * @param ctx The test context
      */
     @Test
+    @EnabledIfDnsRebindingIsSupported
     @EnabledIfRegistrySupportsFeatures(trustAnchorGroups = true, tenantAlias = true)
     public void testConnectX509SucceedsUsingSniWithTenantAlias(final VertxTestContext ctx) {
 
@@ -174,7 +179,9 @@ public void testConnectX509SucceedsUsingSniWithTenantAlias(final VertxTestContex
                     deviceId,
                     cert))
             // WHEN the device connects to the adapter including the tenant alias in the host name
-            .compose(ok -> connectToAdapter(deviceCert, "test-alias." + IntegrationTestSupport.MQTT_HOST))
+            .compose(ok -> connectToAdapter(
+                    deviceCert,
+                    IntegrationTestSupport.getSniHostname(IntegrationTestSupport.MQTT_HOST, "test-alias")))
             .onComplete(ctx.succeeding(conAckMsg -> {
                 // THEN the connection attempt succeeds
                 ctx.verify(() -> assertThat(conAckMsg.code()).isEqualTo(MqttConnectReturnCode.CONNECTION_ACCEPTED));
@@ -189,6 +196,7 @@ public void testConnectX509SucceedsUsingSniWithTenantAlias(final VertxTestContex
      * @param ctx The test context
      */
     @Test
+    @EnabledIfDnsRebindingIsSupported
     @EnabledIfRegistrySupportsFeatures(trustAnchorGroups = true, tenantAlias = true)
     public void testConnectX509FailsUsingSniWithNonExistingTenantAlias(final VertxTestContext ctx) {
 
@@ -208,7 +216,9 @@ public void testConnectX509FailsUsingSniWithNonExistingTenantAlias(final VertxTe
                     deviceId,
                     cert))
             // WHEN the device connects to the adapter including a wrong tenant alias in the host name
-            .compose(ok -> connectToAdapter(deviceCert, "wrong-alias." + IntegrationTestSupport.MQTT_HOST))
+            .compose(ok -> connectToAdapter(
+                    deviceCert,
+                    IntegrationTestSupport.getSniHostname(IntegrationTestSupport.MQTT_HOST, "wrong-alias")))
             .onComplete(ctx.failing(t -> {
                 // THEN the connection is refused
                 ctx.verify(() -> {