From 260a4c4f1188545df41463f8a55d736cca82cc8e Mon Sep 17 00:00:00 2001
From: Eric Weitz <eric.m.weitz@gmail.com>
Date: Tue, 17 Jan 2023 08:55:11 -0500
Subject: [PATCH] 1.41.0

---
 README.md                           | 4 ++--
 dist/js/ideogram.min.js             | 2 +-
 dist/js/ideogram.min.js.LICENSE.txt | 2 +-
 dist/js/ideogram.min.js.map         | 2 +-
 package-lock.json                   | 4 ++--
 package.json                        | 2 +-
 src/js/version.js                   | 2 +-
 7 files changed, 9 insertions(+), 9 deletions(-)
diff --git a/README.md b/README.md
index 27bdf51a..c5f2a94e 100644
--- a/README.md
+++ b/README.md
@@ -19,7 +19,7 @@ A [broader overview](https://speakerdeck.com/eweitz/ideogramjs-chromosome-visual
 
 To link directly to the latest release, copy this snippet:
 ```
-<script src="https://cdn.jsdelivr.net/npm/ideogram@1.40.0/dist/js/ideogram.min.js"></script>
+<script src="https://cdn.jsdelivr.net/npm/ideogram@1.41.0/dist/js/ideogram.min.js"></script>
 ```
 
 You can also easily use the library locally:
@@ -44,7 +44,7 @@ import Ideogram from 'ideogram';
 # Usage
 ```html
 <head>
-  <script src="https://cdn.jsdelivr.net/npm/ideogram@1.40.0/dist/js/ideogram.min.js"></script>
+  <script src="https://cdn.jsdelivr.net/npm/ideogram@1.41.0/dist/js/ideogram.min.js"></script>
 </head>
 <body>
 <script>
diff --git a/dist/js/ideogram.min.js b/dist/js/ideogram.min.js
index 373241e5..fddd31d4 100644
--- a/dist/js/ideogram.min.js
+++ b/dist/js/ideogram.min.js
@@ -1,3 +1,3 @@
 /*! For license information please see ideogram.min.js.LICENSE.txt */
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ua='#_ideogram {padding-left: 5px;} #_ideogram .labeled {padding-left: 15px;} #_ideogram.labeledLeft {padding-left: 15px; padding-top: 15px;} #_ideogram text {font: 9px Tahoma; fill: #000;} #_ideogram .italic {font-style: italic;} #_ideogram .chromosome {cursor: pointer; fill: #AAA;}#_ideogram.no-rotate .chromosome {cursor: default;} #_ideogram .chrLabel, #_ideogram .annot {cursor: pointer;}#_ideogram .chrSetLabel {font-weight: bolder;}#_ideogram .ghost {opacity: 0.2;}#_ideogram .hidden {display: none;}#_ideogram .bandLabelStalk line {stroke: #AAA; stroke-width: 1;}#_ideogram .syntenyBorder {stroke:#AAA;stroke-width:1;}#_ideogram rect.cursor {  fill: #F00;  stroke: #F00;  fill-opacity: .3;  shape-rendering: crispEdges;}#_ideogram .brush .selection {  fill: #F00;  stroke: #F00;  fill-opacity: .3;  shape-rendering: crispEdges;}#_ideogram .noBands {fill: #AAA;}#_ideogram .gneg {fill: #FFF}#_ideogram .gpos25 {fill: #BBB}#_ideogram .gpos33 {fill: #AAA}#_ideogram .gpos50 {fill: 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r=t.organisms[n].scientificName;Wi.select(t.selector).append("text").attr("class","genomeLabel italic").attr("x",55+200*e).attr("y",10).text(r).attr("text-anchor","middle")}))}(r)}(n,e,-40,t),o=Math.round(e.slice(-1)[0]+70),i.multiorganism){r*=8;var a=0;e.forEach((t=>{t>a&&(a=t)})),r=a+30}else r=xOffsets.slice(-1)[0]+30;Wi.select(t.selector).attr("height",r).attr("width",o),Wi.select("#_ideogramTrackLabelContainer").remove(),Wi.select("#_ideogramInnerWrap").insert("div",":first-child").attr("id","_ideogramTrackLabelContainer").style("position","absolute")};const da=function(t){var n,e,r,o,i,a=t.config,s=a.annotationHeight||0;if("vertical"!==a.orientation){t.config.annotLabelHeight=12;var c=t.config.annotLabelHeight;if("demarcateCollinearChromosomes"in t.config==0&&(t.config.demarcateCollinearChromosomes=!0),n=document.querySelectorAll(".chromosome-set"),r=a.numAnnotTracks*(s+c+4)-a.chrWidth+1,e=function(t,n){var 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n.parseCacheLoop=Math.round(d-h),n.parseAnnots=Math.round(performance.now()-d),[e,r,o,i,a,s,c]}},paralog:{metadata:"Paralog",dir:"paralogs",fn:function(t,n){const e=t;n.paralogCache={paralogsByName:e}},parseFn:function(t,n){const e={};let r,o=performance.now();const i=t.split(/\r\n|\n/);n.rawTsvSplit=Math.round(performance.now()-o),o=performance.now();for(let t=0;t<i.length;t++){const n=i[t];if(""===n)continue;if("#"===n[0]){"## prefix"===n.slice(0,9)&&(r=n.split("prefix: ")[1]);continue}const o=n.trim().split(/\t/),a=o[0],s=o[1],c=[];if("_"===o[2][0]){const t=e[o[2].slice(1).toUpperCase()],n=Ya(r,s);for(let e=0;e<t.length;e++){const r=t[e];r!==n&&c.push(r)}c.unshift(Ya(r,o[3]))}else{const t=o.slice(2);for(let n=0;n<t.length;n++){const e=t[n];e!==s&&c.push(Ya(r,e))}}e[a.toUpperCase()]=c}const a=performance.now();return n.parseCacheLoop=Math.round(a-o),e}},interaction:{metadata:"Interaction",dir:"interactions",fn:function(t,n){const 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r=n.trim().split(/\t/),[s,c,l]=r.slice(0,3),u=s.split("-").slice(0,-1).join("-"),h=Xa(r.slice(3),a),f={name:s,biotype:i[c],strand:l,subparts:h};u in e?e[u].push(f):e[u]=[f]}const s=performance.now();return n.parseCacheLoop=Math.round(s-r),e}}};async function Ja(t,n,e,r=null){const o=Qa[t],i=e.config.debug,a=performance.now();let s,c={};if(!function(t,n){const e=function(t){const n=function(t){t=oa(t);for(const n in zi){const e=zi[n],r=oa(e.commonName),o=oa(e.scientificName);if(r===t||o===t)return n}return null}(t);return zi[n]||{}}(t),r="has"+n+"Cache";return e[r]&&!0===e[r]}(n,o.metadata))return;const l=t+"Cache";if(Ideogram[l]&&Ideogram[l][n])return void(e[l]=Ideogram[l][n]);Ideogram[l]||(Ideogram[l]={});const u=(null==o?void 0:o.extension)??"tsv",h=function(t,n,e,r="tsv"){const o=oa(t);return n?n+=e+"/":n=Yi("cache/"+e+"/"),n+o+"-"+e+"."+r+".gz"}(n,r,o.dir,u);return[s,c]=await async function(t,n,e,r=null){const o=performance.now(),i=await async function(t){const n=await 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0!==t.timeout&&window.clearTimeout(t.timeout),t.rawAnnots=t.setOriginalTrackIndexes(t.rawAnnots),t.config.annotationsDisplayedTracks?t.annots=t.updateDisplayedTracks(t.config.annotationsDisplayedTracks):(t.annots=t.processAnnotData(t.rawAnnots),t.config.filterable&&t.initCrossFilter(),t.drawProcessedAnnots(t.annots))}function Za(t){var n=(new Date).getTime(),e=this,r=e.config,o=r.annotations;e.initDrawChromosomes(),r.annotationsPath&&function(t){t.rawAnnots?Ka(t):function n(){t.timeout=setTimeout((function(){!t.rawAnnots||t.rawAnnots&&void 0!==t.rawAnnots.then?n():Ka(t)}),50)}()}(e),function(t,n){var e,r,o,i;if(!0===t.showBandLabels&&(o=(new Date).getTime(),n.hideUnshownBandLabels(),i=(new Date).getTime(),t.debug&&console.log("Time in showing bands: "+(i-o)+" 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n.showGeneStructureInTooltip&&Ja("geneStructure",e,t,r),o}Ja("gene",e,t,r),Ja("paralog",e,t,r),Ja("interaction",e,t,r),n.showGeneStructureInTooltip&&Ja("geneStructure",e,t,r)}(e).then((()=>{e.config.debug&&console.timeEnd("initCache: Ideogram"),e.onLoadCallback&&e.onLoadCallback()}))}class ts{constructor(t){this._config=t,this._description=this._normalize(this._config.ploidyDesc)}getChromosomesNumber(t){if(this._config.ploidyDesc){var n=this._config.ploidyDesc[t];return n instanceof Object?Object.keys(n)[0].length:n.length}return this._config.ploidy||1}_normalize(t){var n,e,r=[];if(!t)return t;for(n in t)"string"==typeof(e=t[n])?("vertical"===this._config.orientation&&(e=e.split("").reverse()),r.push({ancestors:e,existence:this._getexistenceArray(e.length)})):r.push({ancestors:Object.keys(e)[0],existence:e[Object.keys(e)[0]]});return r}_getexistenceArray(t){for(var n=[],e=0;e<t;e++)n.push("11");return n}getSetSize(t){return this._description?this._description[t].ancestors.length:1}getAncestor(t,n){return this._description?this._description[t].ancestors[n]:""}exists(t,n,e){if(this._description){var r=this._description[t].existence[n][e];return Number(r)>0}return!0}}class ns{constructor(t){this._node=t}getLabel(){return Wi.select(this._node.parentNode).select("text.chrLabel").text()}getSetLabel(){return Wi.select(this._node.parentNode).select("text.chrSetLabel").text()}}const es=class{constructor(t,n){if(this._config=t,this._ideo=n,this._ploidy=this._ideo._ploidy,this._translate=void 0,"chrSetMargin"in t)this.chrSetMargin=t.chrSetMargin;else{var e=this._config.chrMargin;this.chrSetMargin=this._config.ploidy>1?e:0}this._tickSize=8,this._isRotated=!1}_getLeftMargin(){return this.margin.left}_getYScale(){return 20/this._config.chrWidth}getChromosomeLabels(t){var n=new ns(t),e=[];return this._ideo.config.ploidy>1&&e.push(n.getSetLabel()),e.push(n.getLabel()),e.filter((function(t){return t.length>0}))}getChromosomeBandLabelTranslate(t){var n,e,r,o=this._ideo,i=this._tickSize,a=o.config.orientation;return"vertical"===a?r="rotate(-90)translate("+(n=i)+","+(e=o.round(2+t.px.start+t.px.width/2))+")":"horizontal"===a&&(r="translate("+(n=o.round(-i+t.px.start+t.px.width/2))+","+(e=-10)+")"),{x:n,y:e,translate:r}}didRotate(t,n){var e,r,o,i,a,s,c,l,u;r=(e=this._ideo).config.taxid,o=n.id.split("-")[0].replace("chr",""),i=(a=e.chromosomes[r][o]).bands,l=(c=Wi.select(n.parentNode)).attr("transform"),u=/scale\(.*\)/.exec(l),l=l.replace(u,""),c.attr("transform",l),s=a.width,(a=e.getChromosomeModel(i,o,r,t)).oldWidth=s,e.chromosomes[r][o]=a,e.drawChromosome(a),e.handleRotateOnClick(),e.rawAnnots&&(e.displayedTrackIndexes?e.updateDisplayedTracks(e.displayedTrackIndexes):(e.annots=e.processAnnotData(e.rawAnnots),e.drawProcessedAnnots(e.annots),e.config.filterable&&e.initCrossFilter())),!0===e.config.showBandLabels&&(e.drawBandLabels(e.chromosomes),e.hideUnshownBandLabels()),e.onDidRotateCallback&&e.onDidRotateCallback(a)}rotate(t,n,e){var r,o,i,a;r=this._ideo,a=r.selector+" .chrSetLabel, "+r.selector+" .chrLabel",i=document.querySelector(r.selector).getBoundingClientRect(),o=Wi.selectAll(r.selector+" g.chromosome").filter((function(){return this!==e})),this._isRotated?(this._isRotated=!1,r.config.chrHeight=r.config.chrHeightOriginal,r.config.chrWidth=r.config.chrWidthOriginal,r.config.annotationHeight=r.config.annotationHeightOriginal,this.rotateBack(t,n,e,(function(){o.style("display",null),Wi.selectAll(a).style("display",null),r._layout.didRotate(n,e)}))):(this._isRotated=!0,o.style("display","none"),Wi.selectAll(a).style("display","none"),this.rotateForward(t,n,e,(function(){var t,o,a;r.config.chrHeightOriginal=r.config.chrHeight,r.config.chrWidthOriginal=r.config.chrWidth,r.config.annotationHeightOriginal=r.config.annotationHeight,"VerticalLayout"===r._layout._class?(o=i.width-20,a=window.innerWidth-20):(o=i.height-10,a=window.innerHeight-10),t=a<o?a:o,t-=2*r.config.chrMargin,r.config.chrHeight=t,r.config.chrWidth*=2.3,r.config.annotationHeight*=1.7,r._layout.didRotate(n,e)})))}getChromosomeLabelClass(){return 1===this._config.ploidy?"chrLabel":"chrSetLabel"}_getAdditionalOffset(){var t=this._config,n=t.annotationsNumTracks||t.numAnnotTracks||1;return(t.annotationHeight||0)*n}_getChromosomeSetSize(t){return this._ploidy.getSetSize(t)*this._config.chrWidth*2+this.chrSetMargin}getChromosomeSetLabelAnchor(){return"middle"}getChromosomeLabelYPosition(){return-5.5}getChromosomeSetLabelYPosition(t){return 1===this._config.ploidy?this.getChromosomeLabelYPosition(t):-2*this._config.chrWidth}},rs=class extends es{constructor(t,n){super(t,n),this._class="VerticalLayout",this.margin={top:30,left:15}}rotateForward(t,n,e,r){var o="translate(20, 25) "+this.getChromosomeScale(e);Wi.select(e.parentNode).transition().attr("transform",o).on("end",r);var i=this.getChromosomeLabels(e),a=1.3*(20+this._config.chrWidth);Wi.select(this._ideo.getSvg()).append("g").attr("class","tmp").selectAll("text").data(i).enter().append("text").attr("class",(function(t,n){return 0===n&&2===i.length?"chrSetLabel":null})).attr("x",0).attr("y",a).style("opacity",0).text(String).transition().style("opacity",1),this._ideo.config.orientation="horizontal"}rotateBack(t,n,e,r){var o=this.getChromosomeScaleBack(e),i=this.getChromosomeSetTranslate(t);Wi.select(e.parentNode).transition().attr("transform",i+" "+o).on("end",r),Wi.selectAll(this._ideo.selector+" g.tmp").style("opacity",0).remove(),this._ideo.config.orientation="vertical"}getHeight(){return this._config.chrHeight+1.5*this.margin.top}getWidth(){return"97%"}getChromosomeBandTickY1(){return 2}getChromosomeBandTickY2(){return 10}getChromosomeSetLabelTranslate(){return"rotate(-90)"}getChromosomeBandLabelAnchor(){return null}getChromosomeScale(t){var n,e;return n=Wi.select(this._ideo.selector).node().getBoundingClientRect(),e=t.getBoundingClientRect(),"scale("+n.width/e.height*.97+", "+this._getYScale()+")"}getChromosomeScaleBack(t){var n,e,r;return e=(r=this._ideo.config).taxid,n=t.id.split("-")[0].replace("chr",""),"scale("+this._ideo.chromosomes[e][n].oldWidth/(3*r.chrHeight)*.97+", "+1/this._getYScale()+")"}getChromosomeSetTranslate(t){return"rotate(90) translate("+this.margin.top+", -"+this.getChromosomeSetYTranslate(t)+")"}getChromosomeSetYTranslate(t){var n,e=this._getAdditionalOffset(),r=this._config,o=r.chrMargin,i=r.chrWidth;if(!r.ploidyDesc)return"histogram"===r.annotationsLayout?o+t*(o+i+3)+2*r.barWidth:(n=i+t*(o+i)+2*e+("legendPad"in r?r.legendPad:0),e>0?n:n+4+2*t);if(!this._translate){var a;this._translate=[this._ploidy.getSetSize(0)*i*2];for(var s=1;s<this._config.ploidyDesc.length;s++)a=this._translate[s-1],this._translate[s]=a+this._getChromosomeSetSize(s-1)}return this._translate[t]}getChromosomeSetLabelXPosition(){return this._config.chrWidth*this._config.ploidy/-2}getChromosomeLabelXPosition(){return this._config.chrWidth/-2}},os=class extends es{constructor(t,n){super(t,n),this._class="HorizontalLayout",this.margin={left:20,top:30}}_getLeftMargin(){var t=es.prototype._getLeftMargin.call(this);return this._config.ploidy>1&&(t*=1.8),t}rotateForward(t,n,e,r){var o;Wi.select(e.parentNode).transition().attr("transform","rotate(90) translate(30, -37.5) ").on("end",r),o=this.getChromosomeLabels(e),Wi.select(this._ideo.getSvg()).append("g").attr("class","tmp").selectAll("text").data(o).enter().append("text").attr("class",(function(t,n){return 0===n&&2===o.length?"chrSetLabel":null})).attr("x",26).attr("y",(function(t,n){return 12*(n+1+o.length%2)})).style("text-anchor","middle").style("opacity",0).text(String).transition().style("opacity",1),this._ideo.config.orientation="vertical"}rotateBack(t,n,e,r){var o=this.getChromosomeSetTranslate(t);Wi.select(e.parentNode).transition().attr("transform",o).on("end",r),Wi.selectAll(this._ideo.selector+" g.tmp").style("opacity",0).remove(),this._ideo.config.orientation="horizontal"}getHeight(t){void 0===t&&(t=this._config.taxids[0]);var n=this._config.chromosomes[t].length,e=this.getChromosomeSetYTranslate(n-1);return(e+=this._getChromosomeSetSize(n-1))+2*this._getAdditionalOffset()}getWidth(){return this._config.chrHeight+1.5*this.margin.top}getChromosomeSetLabelAnchor(){return"end"}getChromosomeBandLabelAnchor(){return null}getChromosomeBandTickY1(){return 2}getChromosomeBandTickY2(){return 10}getChromosomeSetLabelTranslate(){return null}getChromosomeSetTranslate(t){return"translate("+this._getLeftMargin()+", "+this.getChromosomeSetYTranslate(t)+")"}getChromosomeSetYTranslate(t){if(!this._config.ploidyDesc)return this._config.chrMargin*(t+1);if(!this._translate){this._translate=[1];for(var n=1;n<this._config.ploidyDesc.length;n++)this._translate[n]=this._translate[n-1]+this._getChromosomeSetSize(n-1)}return this._translate[t]}getChromosomeSetLabelXPosition(t){return 1===this._config.ploidy?this.getChromosomeLabelXPosition(t):-20}getChromosomeSetLabelYPosition(t){var n=this._ploidy.getSetSize(t),e=this._config,r=e.chrMargin,o=e.chrWidth;return 1===e.ploidy?o/2+3:n*r/2}getChromosomeLabelXPosition(){return-8}getChromosomeLabelYPosition(){return this._config.chrWidth}},is=class extends es{constructor(t,n){super(t,n),this._class="PairedLayout",this.margin={left:30}}getHeight(){return this._config.chrHeight+1.5*this.margin.left}getWidth(){return"97%"}getChromosomeBandTickY1(t){return t%2?this._config.chrWidth:2*this._config.chrWidth}getChromosomeBandTickY2(t){var n=this._config.chrWidth;return t%2?n-this._tickSize:2*n+this._tickSize}getChromosomeBandLabelAnchor(t){return t%2?null:"end"}getChromosomeBandLabelTranslate(t,n){var e=n%2?10:-this._config.chrWidth-10,r=this._ideo.round(t.px.start+t.px.width/2)+3;return{x:r,y:r,translate:"rotate(-90) translate("+e+", "+r+")"}}getChromosomeLabelXPosition(){return-this._tickSize}getChromosomeSetLabelXPosition(){return this._config.chrWidth/-2}getChromosomeSetLabelTranslate(){return"rotate(-90)"}getChromosomeSetTranslate(t){var n=this.getChromosomeSetYTranslate(t);return"rotate(90) translate("+this.margin.left+", -"+n+")"}getChromosomeSetYTranslate(t){return 200*(t+1)}},as=class extends es{constructor(t,n){super(t,n),this._class="SmallLayout",this.margin={left:36.5,top:10};var e=this._ideo.getTaxid(this._ideo.config.organism);this.chrs=t.chromosomes[e];var r=this.chrs.length;this.chrsPerRow=Math.ceil(r/t.rows)}getHeight(){var t=1.25*this._config.chrHeight;return this._config.rows*(t+this.margin.top)}getWidth(){return"97%"}getChromosomeBandLabelTranslate(){}getChromosomeSetLabelTranslate(){return"rotate(-90)"}getChromosomeSetTranslate(t){var n,e;return t>this.chrsPerRow-1?(n=this.margin.left+1.3*this._config.chrHeight,e=this.getChromosomeSetYTranslate(t-this.chrsPerRow)):(n=this.margin.left,e=this.getChromosomeSetYTranslate(t)),"rotate(90) translate("+n+", -"+e+")"}getChromosomeSetYTranslate(t){var n=.3*this._getAdditionalOffset();return this.margin.left*t+this._config.chrWidth+2*n+n*t}getChromosomeSetLabelXPosition(t){return(this._ploidy.getSetSize(t)*this._config.chrWidth+20)/-2+(this._config.ploidy>1?0:this._config.chrWidth)}getChromosomeLabelXPosition(){return this._config.chrWidth/-2}};function ss(t){var n=this;n.config.annotationsPath&&n.fetchAnnots(n.config.annotationsPath),function(t){if("ploidyDesc"in t.config&&"string"==typeof t.config.ploidyDesc){for(var n=[],e=0;e<t.numChromosomes;e++)n.push(t.config.ploidyDesc);t.config.ploidyDesc=n}t._ploidy=new ts(t.config)}(n),n._layout=function(t){var n=t.config;return"perspective"in n&&"comparative"===n.perspective?new is(n,t):"rows"in n&&n.rows>1?new as(n,t):"vertical"===n.orientation?new rs(n,t):"horizontal"===n.orientation?new os(n,t):new rs(n,t)}(n),function(t){Wi.selectAll(t.config.container+" #_ideogramOuterWrap").remove(),Wi.select(t.config.container).append("div").attr("id","_ideogramOuterWrap").append("div").attr("id","_ideogramTrackLabelContainer").style("position","absolute"),Wi.select(t.config.container+" #_ideogramOuterWrap").append("div").attr("id","_ideogramMiddleWrap").style("position","relative").style("overflow-x","auto").style("transform","translateZ(0)").append("div").attr("id","_ideogramInnerWrap").append("svg").attr("id","_ideogram").attr("class",function(t){var n="";return t.config.showChromosomeLabels&&("horizontal"===t.config.orientation?n+="labeledLeft ":n+="labeled "),!1===t.config.rotatable&&(n+="no-rotate "),t.config.annotationsLayout&&"overlay"===t.config.annotationsLayout&&(n+="faint"),n}(t)).attr("width",t._layout.getWidth()).attr("height",t._layout.getHeight()).html(t.getBandColorGradients())}(n),n.isOnlyIdeogram=1===document.querySelectorAll("#_ideogram").length,function(t){Wi.select(t.config.container+" #_ideogramOuterWrap").append("div").attr("class","_ideogramTooltip").attr("id","_ideogramTooltip").style("opacity",0).style("position","fixed").style("text-align","center").style("padding","4px").style("font","12px sans-serif").style("background","white").style("border","1px solid black").style("border-radius","5px").style("z-index","1000")}(n),n.finishInit(t)}var cs="";function ls(t,n,e){return e.config.dataDir+t[n]}function us(t,n,e){var r=e.config.ploidy;return"sex"in e.config&&(2===r&&e.sexChromosomes.index+1===n||"female"===e.config.sex&&"Y"===t.name)}function hs(t,n,e,r){var o,i,a,s,c;for(o=0;o<n.length;o++)a=n[o],void 0!==t&&(i=t[o]),c=o+r.config.taxids.indexOf(e),s=r.getChromosomeModel(i,a,e,c),"string"!=typeof a&&(a=a.name.split(" ").slice(-1)[0].replace("chr","")),r.chromosomes[e][a]=s,r.chromosomesArray.push(s),us(s,o,r)||r.drawChromosome(s)}function fs(t,n){"undefined"!=typeof chrBands&&t.length>=chrBands.length/2&&(n.coordinateSystem="bp")}function ds(){var t,n,e,r,o=this,i=o.config.taxids;for(n=0;n<i.length;n++)t=i[n],e=o.config.chromosomes[t],r=o.bandsArray[t],o.config.showNonNuclearChromosomes||(e=e.filter((t=>"MT"!==t)),void 0!==r&&(r=r.filter((t=>"MT"!==t[0].chr)))),fs(e,o),o.chromosomes[t]={},o.setSexChromosomes(e),hs(r,e,t,o),o.config.showBandLabels&&o.drawBandLabels(o.chromosomes),o.handleRotateOnClick(),o._gotChrModels=!0}function ms(){var t=this;"rotatable"in t.config&&!1===t.config.rotatable?Wi.selectAll(t.selector).style("cursor","default"):Wi.selectAll(t.selector+" .chromosome-set").on("click",(function(){const n=this.children[1];t.rotateAndToggleDisplay(n)}))}function ps(){call(this.onLoadCallback)}function gs(t,n,e){var r=e.organisms[t],o=[oa(r.scientificName)],i=r.assemblies,a=e.config.resolution;return n!==i.default&&o.push(n),"9606"===t&&(n in i==="false"&&Object.values(i).includes(config.assembly)||""!==a&&850!==a)&&o.push(a),o=o.join("-"),["9606","10090","10116"].includes(t)&&!e.config.showFullyBanded&&(o+="-no-bands"),o+".json"}function ys(t,n,e){var r,o,i,a=e.config;r=e.organisms[t],a.assembly||(e.config.assembly="default"),o=r.assemblies,i=gs(t,e.assemblyIsAccession()?a.assembly:o[a.assembly],e);var s="-1"===t;return(t in e.organismsWithBands||s)&&(n[t]=i),n}function vs(t,n,e,r){return function(t,n,e){var r=ls(t,n,e);return(!(void 0!==window.chrBands&&""===cs)||cs!==r)&&function(t){return"assembly"in t.config&&!1===/(GCA_)/.test(t.config.assembly)}(e)&&n in t}(n,t,r)?function(t,n,e,r){var o=ls(t,n,r);return r.numBandDataResponses||(r.numBandDataResponses=0),Xi(o).then((function(n){return n.json().then((function(e){cs=o,delete window.chrBands,window.chrBands=e.chrBands,function(t,n,e,r){var o,i,a;for(o in n)a=n[o],t.includes(a)&&""!==a&&(i=o);r.bandData[i]=e}(n.url,t,chrBands,r)}))}))}(n,t,0,r).then((function(){return r.processBandData(t)})):new Promise((function(n){r.processBandData(t),n([t,void 0])}))}var bs={},ws={},_s={};function xs(t){var n=(t=t||this).config.container;_s[n]?(ws[n]=!0,bs[n]=t):(_s[n]=!0,function(t){return new Promise((function(n){var e=t.config.organism;"number"==typeof e?t.getOrganismFromEutils(e,(function(){t.getTaxids(n)})):t.getTaxids(n)}))}(t).then((function(e){var r=e[0];t.config.taxid=r,t.config.taxids=e,t.organismScientificName=t.getScientificName(t.config.taxid),function(t,n,e){var r,o,i,a=[];for(i in r={},zi)r[i]="";for(o=0;o<t.length;o++)r=ys(i=String(t[o]),r,e),a.push(vs(i,r,0,e));Promise.all(a).then((function(t){var r,i,a;for(o=0;o<t.length;o++)i=(r=t[o])[0],a=r[1],"bandsArray"in e==0&&(e.bandsArray={}),e.bandsArray[i]=a;e.writeContainer(n)}))}(e,(new Date).getTime(),t),_s[n]=!1,ws[n]&&(ws[n]=!1,xs(bs[n]))})))}class As{constructor(t,n){this.rawAnnots=this.parseBed(t,n)}static componentToHex(t){var n=parseInt(t,10).toString(16);return 1===n.length?"0"+n:n}static rgbToHex(t,n,e){return"#"+As.componentToHex(t)+As.componentToHex(n)+As.componentToHex(e)}parseGenomicCoordinates(t,n){var e,r,o,i;return e=t[0],r=parseInt(t[1],10),i=(o=parseInt(t[2],10))-r,n&&(e=e.slice(3)),[e,r,o,i]}parseAnnotFromTsvLine(t,n,e){var r,o,i,a,s,c,l,u=t.split(/\s/g);return[i,a,stop,length]=this.parseGenomicCoordinates(u,e),-1===(o=n.indexOf(i))?[null,null]:(r=["",a,length,0],u.length>=4&&(l=u[3],r[0]=l),u.length>=8&&(s=u[8].split(","),c=As.rgbToHex(s[0],s[1],s[2]),r.push(c)),[o,r])}parseRawAnnots(t,n,e,r){var o,i,a,s,c,l;for(l=!0,!1===isNaN(parseInt(e[n],10))&&(l=!1),o=n;o<e.length;o++)i=e[o],[a,s]=this.parseAnnotFromTsvLine(i,r,l),null!==a&&t[a].annots.push(s);return c=["name","start","length","trackIndex"],e[n].length>=8&&c.push("color"),{keys:c,annots:t}}parseBed(t,n){var e,r,o,i,a=[],s=t.split(/\r\n|\n/);for(r=Object.keys(n.chromosomes[n.config.taxid]),e=0;e<r.length;e++)o=r[e],a.push({chr:o,annots:[]});return i=0,("chr"===s[0].slice(0,3)||isNaN(parseInt(s[0],10)))&&(i=1),this.parseRawAnnots(a,i,s,r)}}class Cs{constructor(t,n){this.rawAnnots=this.parseTsv(t,n)}parseGenomicCoordinates(t){return[t[1],parseInt(t[2],10),parseInt(t[3],10)]}parseTsv(t,n){const e=t.split(/\r\n|\n/),r=Object.keys(n.chromosomes[n.config.taxid]),o=[];for(let t=0;t<r.length;t++){const n=r[t];o.push({chr:n,annots:[]})}let i;const a={},s=[];for(let t=0;t<e.length;t++){const n=e[t];if(""===n)continue;if("#"===n[0]){if("#"===n[1]){const t=n.split(" keys: ");if(t.length>1){const n=t[0].slice(3),e=t[1].split(";");a[ra(n)]=e}}else i=n.slice(1).trim().split(/\t/).map((t=>ra(t))),i.slice(4).forEach(((t,n)=>s.push(ra(t))));continue}const c=n.trim().split(/\t/),l=c[0],[u,h,f]=this.parseGenomicCoordinates(c),d=r.indexOf(u);if(-1===d)continue;const m=c.slice(4);for(let t=0;t<4;t++){const n=s[t];if(n in a){const e=a[n],r=c[4+t].split(";"),o=[];if(""!==r[0])for(let t=0;t<r.length;t++){const n={},i=r[t].split("!");for(let t=0;t<i.length;t++){const r=e[t],o=i[t];n[ra(r)]=o}o.push(n)}m[t]=o}}const p=[l,u,h,f].concat(m);o[d].annots.push(p)}return{keys:i,annots:o,innerKeysByField:a}}}var Ss=["name","start","length","trackIndex","trackIndexOriginal","color"],ks={3:["00B","DDD","F00"],5:["00D","66D","DDD","F88","F00"],17:["00D","00D","00D","00D","00D","44D","44D","DDD","DDD","DDD","DDD","F88","F66","F22","F22","F00","F00","F00"]};function Ts(t){var n,e,r;if(t.rawAnnots.metadata&&t.rawAnnots.metadata.trackLabels)n=t.rawAnnots.metadata.trackLabels;else if(t.config.heatmaps)for(n=[],e=t.config.heatmaps,r=0;r<e.length;r++)n.push(e[r].key);else n=t.rawAnnots.keys.slice(0).filter((t=>!Ss.includes(t)));return t.displayedTrackIndexes&&(n=n.filter((function(n,e){return t.displayedTrackIndexes.includes(e+1)}))),n}function Ls(t){var n,e,r=t.rawAnnots;if(!r.metadata||r.metadata.heatmapThresholds||t.config.heatmapThresholds)return n=t.config.heatmapThresholds?t.config.heatmapThresholds:t.rawAnnots.metadata.heatmapThresholds,e=ks[n.length+1],n=n.map(((t,n)=>[t,"#"+e[n]])),n.push(["+","#"+e.slice(-1)[0]]),n}function Ms(t,n,e,r,o){return t===n&&"+"===o&&e>r||e===o||0!==t&&t!==n&&e<=o&&e>r||0===t&&e<=o}function Ns(t,n){var e,r,o,i,a,s,c,l;for(e=0;e<t.length;e++)r=t.length-1,i=(o=t[e])[0],a=parseFloat(i),!1===isNaN(a)&&(i=a),0!==e&&(c=parseFloat(t[e-1][0])),s=o[1],Ms(e,r,n,c,i)&&(l=s);return l}function Es(t,n,e){var r,o,i,a,s,c=t.width,l=[],u=e.config.annotLabelHeight,h=e.config.numAnnotTracks;for(r=0;r<h;r++)i=e.config.annotationHeight+u+4,s=t.id+"-canvas-"+r,o=n,t.chrIndex>0&&(o+=e.config.chrMargin*t.chrIndex-1),a=Wi.select(e.config.container+" #_ideogramInnerWrap").append("canvas").attr("id",s).attr("width",c+1).attr("height",i).style("position","absolute").style("left",o+"px").style("top",i*r+1+"px").nodes()[0].getContext("2d"),l.push([a,t]);return l}function Ps(t,n,e){var r,o,i,a,s=e.config.annotLabelHeight,c=e.config.annotationHeight,l=e.config.demarcateCollinearChromosomes,u=c+s+4;for(r=0;r<t.length;r++)if(i=n[(o=t[r]).trackIndex][0],a=n[o.trackIndex][1],i.fillStyle=o.color,l){if(o.startPx<1||o.startPx>a.width-1)continue;i.fillRect(o.startPx,1,.5,u)}else i.fillRect(o.startPx,s+1,.5,c);if(l)for(r=0;r<n.length;r++)i=n[r][0],a=n[r][1],i.fillStyle="#555",0===a.chrIndex&&i.fillRect(0,0,1,u),i.fillRect(a.width-1,0,1.1,u),i.fillRect(0,0,a.width+1,1),e.config.chrMargin&&i.fillRect(0,0,1.1,u)}function Ds(t,n,e){var r,o,i,a=e.config.annotationHeight,s=e._layout.margin.top;for(i=t.values,r=0;r<i.length;r++)n.fillStyle=i[r],o=(r-1)*a,n.fillRect(o,t.startPx+s,a,2)}function Bs(t,n,e,r,o,i,a){var s,c,l,u,h,f,d,m=a.config.heatmapThresholds;for(s=0;s<e.annots.length;s++){for(u=e.annots[s],(l={}).values=[],c=0;c<3;c++)l[i[c]]=u[c];for(c=3;c<i.length;c++)d=Ns(m,u[c]),l.values.push(d);h=l.start+l.length,l.chr=e.chr,l.chrIndex=o,l.startPx=a.convertBpToPx(r,l.start),f=a.convertBpToPx(r,h),l.px=Math.round((l.startPx+f)/2),t.push(l)}return t.shift(),[t,n]}function Fs(t){!1!==t.config.showTrackLabel&&(t.hideTrackLabelTimeout=window.setTimeout((function(){Wi.select(t.config.container+" #_ideogramTrackLabel").transition().duration(500).style("opacity",0)}),250))}function Is(t,n,e,r){var o,i,a,s,c,l=[],u=r.config.numAnnotTracks;for(o=0;o<u;o++)a=r.config.annotationHeight,c=t.id+"-canvas-"+o,i=n-a*(u-o)-7,s=Wi.select(r.config.container+" #_ideogramInnerWrap").append("canvas").attr("id",c).attr("width",a).attr("height",e).style("position","absolute").style("left",i+"px").nodes()[0].getContext("2d"),l.push(s);return l}function $s(t,n,e,r){var 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null===e?"vertical"===n.config.orientation?(i=l-12,a=f-12):(i=c,a=h):(i=e,a=e),r.startPx=n.convertBpToPx(r.chr,r.start)+i,r.stopPx=n.convertBpToPx(r.chr,r.stop)+i,o.startPx=n.convertBpToPx(o.chr,o.start)+a,o.stopPx=n.convertBpToPx(o.chr,o.stop)+a,[r,o]}function gc(t,n,e,r,o){t.append("line").attr("class","syntenyBorder").attr("x1",n).attr("x2",e).attr("y1",r.startPx).attr("y2",o.startPx),t.append("line").attr("class","syntenyBorder").attr("x1",n).attr("x2",e).attr("y1",r.stopPx).attr("y2",o.stopPx)}function yc(t,n,e,r,o){t.append("line").attr("class","syntenyBorder").attr("x1",r.startPx-15).attr("x2",o.startPx-15).attr("y1",n).attr("y2",e),t.append("line").attr("class","syntenyBorder").attr("x1",r.stopPx-15).attr("x2",o.stopPx-15).attr("y1",n).attr("y2",e)}function vc(t,n,e,r,o,i){var a,s;Math.abs(r.startPx-r.startPx)<2&&Math.abs(r.stopPx-r.stopPx)<2?(a=i.color,s=i.width):(a="",s=""),t.append("line").attr("class","syntenyBorder").attr("x1",n).attr("x2",e).attr("y1",r.startPx).attr("y2",o.startPx).style("stroke",a).style("stroke-width",s),t.append("line").attr("class","syntenyBorder").attr("x1",n).attr("x2",e).attr("y1",r.stopPx).attr("y2",o.stopPx).style("stroke",a).style("stroke-width",a)}function bc(t,n,e,r,o,i){var a=i.split("__").map((t=>"label_"+t));if("name"in r){t.append("text").attr("id",a[0]).attr("y",r.startPx+3).text(r.name);var s=document.querySelector("#"+a[0]).getBoundingClientRect().width;Wi.select("#"+a[0]).attr("x",n-15-s)}"name"in o&&t.append("text").attr("id",a[1]).text(o.name).attr("x",e+15).attr("y",o.startPx+3).text(o.name)}function wc(t){var n=(new Date).getTime(),e=this,r=e.config;if(e.syntenicRegions=t,r.multiorganism&&"collinear"===r.geometry)return"vertical"===r.orientation?function(t,n){var e=(new Date).getTime();(function(t,n,e){var r,o,i,a,s,c,l,u;for(r=0;r<t.length;r++)o=t[r],[i,a]=pc(o,e),dc(s=fc(n,i.chr.id+"_"+i.start+"_"+i.stop+"___"+a.chr.id+"_"+a.start+"_"+a.stop,e),l=(c=e.config.chrWidth)+51,u=c+245,i,a,o),gc(s,l,u,i,a)})(t,Wi.select(n.selector).insert("g",":first-child").attr("class","synteny"),n),function(t,n){var e=(new Date).getTime();n.config.debug&&console.log("Time in drawSyntenicRegions: "+(e-t)+" ms")}(e,n)}(t,e):function(t,n){var e=(new Date).getTime();(function(t,n,e){var r,o,i,a,s,c,l,u;for(r=0;r<t.length;r++)o=t[r],[i,a]=pc(o,e),mc(s=fc(n,i.chr.id+"_"+i.start+"_"+i.stop+"___"+a.chr.id+"_"+a.start+"_"+a.stop,e),l=(c=e.config.chrWidth)+31,u=c+191,i,a,o),yc(s,l,u,i,a)})(t,Wi.select(n.selector).insert("g",":first-child").attr("class","synteny"),n),function(t,n){var e=(new Date).getTime();n.config.debug&&console.log("Time in drawSyntenicRegions: "+(e-t)+" ms")}(e,n)}(t,e);(function(t,n,e,r){var o,i,a,s,c,l,u,h,f;for(o=0;o<t.length;o++)i=t[o],[a,s]=pc(i,r,e),l=fc(n,c=a.chr.id+"_"+a.start+"_"+a.stop+"___"+s.chr.id+"_"+s.start+"_"+s.stop,r),u=r.config.chrWidth,dc(l,h=r._layout.getChromosomeSetYTranslate(0),f=r._layout.getChromosomeSetYTranslate(1)-u,a,s,i),vc(l,h,f,a,s,i),bc(l,h,f,a,s,c)})(t,Wi.select(e.selector).insert("g",":first-child").attr("class","synteny"),e._layout.margin.left,e),function(t,n){var e=(new Date).getTime();n.config.debug&&console.log("Time in drawSyntenicRegions: "+(e-t)+" ms")}(n,e)}function _c(){var t=this;t.config.numAnnotTracks=t.config.annotationsNumTracks,Wi.selectAll(t.selector+" .annot").remove(),t.drawAnnots(t.processAnnotData(t.rawAnnots))}function xc(t){var n,e,r,o=this,i=o.rawAnnots.annots;return o.config.numAnnotTracks=t.length,n=function(t,n){var e,r,o,i,a,s,c;for(r=[],i=0;i<t.length;i++){for(o=t[i],a=[],s=0;s<o.annots.length;s++)c=(e=o.annots[s].slice())[3]+1,n.includes(c)&&(e[3]=n.indexOf(c),a.push(e));r.push({chr:o.chr,annots:a})}return r}(i,t),r={keys:o.rawAnnots.keys,annots:n},"collinear"===o.config.geometry&&da(o),e=o.processAnnotData(r),Wi.selectAll(o.selector+" .annot").remove(),o.displayedTrackIndexes=t,o.drawAnnots(e),e}function Ac(t){var n,e,r=this;return(n=t.keys).length<4||"trackIndex"!==n[3]||"trackIndexOriginal"===n[4]||(e=function(t,n){var e,r,o,i,a,s,c,l=[];for(c=1,e=0;e<t.length;e++){for(o=t[e],a=[],r=0;r<o.annots.length;r++)(s=(i=o.annots[r].slice())[3])+1>c&&(c=s+1),i.splice(4,0,s),a.push(i);l.push({chr:o.chr,annots:a})}return n.numAvailTracks=c,l}(t.annots,r),n.splice(4,0,"trackIndexOriginal"),t={keys:n,annots:e},r.rawAnnots.metadata&&(t.metadata=r.rawAnnots.metadata)),t}var Cc=[["F00"],["F00","88F"],["F00","CCC","88F"],["F00","FA0","0AF","88F"],["F00","FA0","CCC","0AF","88F"],["F00","FA0","875","578","0AF","88F"],["F00","FA0","875","CCC","578","0AF","88F"],["F00","FA0","7A0","875","0A7","578","0AF","88F"],["F00","FA0","7A0","875","CCC","0A7","578","0AF","88F"],["F00","FA0","7A0","875","552","255","0A7","578","0AF","88F"]];function Sc(t,n,e,r,o,i,a){return a.config.annotationTracks?o=function(t,n,e,r,o){var i;return n.trackIndex=e[3],(i=o.config.annotationTracks[n.trackIndex]).color&&(n.color=i.color),i.shape&&(n.shape=i.shape),t[r].annots.push(n),t}(o,t,e,i,a):"trackIndex"===n[3]&&1!==a.numAvailTracks?[o,r]=function(t,n,e,r,o,i){var a=Cc[i.numAvailTracks-1];return t.trackIndex=n[3],t.trackIndexOriginal=n[4],t.color="#"+a[t.trackIndexOriginal],t.trackIndex>i.config.numTracks-1?(t.trackIndex in e?e[t.trackIndex].push(t):e[t.trackIndex]=[t],[r,e]):(r[o].annots.push(t),[r,e])}(t,e,r,o,i,a):o=function(t,n,e,r){return n.trackIndex=0,n.color||(n.color=r.config.annotationsColor),n.shape||(n.shape="triangle"),t[e].annots.push(n),t}(o,t,i,a),[o,r]}function kc(t,n){return"_c"+t+"_a"+n}function Tc(t,n,e,r,o,i,a){var s,c,l,u;const h=!a.config.annotationsLayout||"tracks"===a.config.annotationsLayout;for(s=0;s<e.annots.length;s++){for(u=e.annots[s],l={},c=0;c<i.length;c++)l[i[c]]=u[c];l.stop=l.start+l.length,l.chr=e.chr,l.chrIndex=o,l.startPx=a.convertBpToPx(r,l.start),l.stopPx=a.convertBpToPx(r,l.stop),l.px=Math.round((l.startPx+l.stopPx)/2),h&&(l.domId=kc(o,s)),[t,n]=Sc(l,i,u,n,t,o,a)}if(h)for(a.annotSortFunction?(t[o].annots=$c(t[o].annots,a),t[o].annots.sort(((t,n)=>-a.annotSortFunction(t,n)))):t[o].annots.sort(((t,n)=>t[1]-n[1])),s=0;s<t[o].annots.length;s++)t[o].annots[s].domId=kc(o,s);return[t,n]}function Lc(t){console.warn('Chromosome "'+t.chr+'" undefined in ideogram; '+t.annots.length+" annotations not shown")}function Mc(t){var n,e,r,o=this;return n=t.keys,t=t.annots,[e,r]=function(t,n,e){var r,o,i,a,s=[],c={};for(r=-1,o=0;o<t.length;o++)i=t[o],void 0!==(a=e.chromosomes[e.config.taxid][i.chr])?(r++,s.push({chr:i.chr,annots:[]}),"heatmap-2d"!==e.config.annotationsLayout?[s,c]=Tc(s,c,i,a,r,n,e):[s,c]=Bs(s,c,i,a,r,n,e)):Lc(i);return[s,c]}(t,n,o),e=function(t,n){var e,r,o,i,a,s;for(e=t,t=[],s=n.chromosomesArray,r=0;r<s.length;r++)for(a=s[r].name,o=0;o<e.length;o++)(i=e[o]).chr===a&&t.push(i);return t}(e,o),function(t,n){var e,r=n.config.annotationsLayout,o=n.config.numAnnotTracks;!/heatmap/.test(r)&&o>10&&console.error("Ideogram only displays up to 10 tracks at a time.  You specified "+o+" tracks.  Perhaps consider a different way to visualize your data."),(e=Object.keys(t).length)&&console.warn("Ideogram configuration specified "+o+" tracks, but loaded annotations contain "+e+" extra tracks.")}(r,o),e}class Nc{constructor(t,n){this.matrix=t,this.ideo=n}setRawAnnots(){var t,n,e;return t=this,n=this.ideo,e=this.matrix,new Promise((function(r){t.rawAnnots=t.fetchCoordinates(n).then((function(o){t.coordinates=o,r(t.parseExpressionMatrix(e,n))}))}))}fetchCoordinates(t){var n={};if("human"===t.config.organism){var e=t.config.dataDir+"../../annotations/Homo_sapiens,_Ensembl_80.tsv";return new Promise((function(r){t.fetch(e,"text").then((function(t){var e,o,i,a,s,c,l;for(e=t.split(/\r\n|\n/).slice(1),o=0;o<e.length;o++)[i,a,s,,c]=e[o].split(/\s/g),i=parseInt(i),l=(a=parseInt(a))-i,n[s]=[c,i,l];r(n)}))}))}throw Error("Expression matrix parsing is only supported for human")}parseAnnotFromTsvLine(t,n){var e,r,o,i,a,s=t.split(/\s/g);return(i=s[0])in this.coordinates==0?[null,null]:(a=s.slice(1).map((t=>parseFloat(t))),[r,o,length]=this.coordinates[i],-1===(e=n.indexOf(r))?[null,null]:[e,[i,o,length].concat(a)])}parseExpressionMatrix(t,n){var e,r,o,i,a,s,c=[],l=t.split(/\r\n|\n/);for(r=Object.keys(n.chromosomes[n.config.taxid]),e=0;e<r.length;e++)c.push({chr:r[e],annots:[]});for(e=1;e<l.length;e++)i=l[e],[a,s]=this.parseAnnotFromTsvLine(i,r),null!==a&&c[a].annots.push(s);return o=l[0].split(/\s/g),{keys:["name","start","length"].concat(o),annots:c}}}function Ec(){const t=this,n={};t.annots.forEach((e=>{e.annots.forEach((e=>{const r=t.annotDescriptions.annots[e.name];n[e.name]=[e.name,r.ensemblId,e.chr,e.start,e.stop,e.length,r.type]}))}));const e=[["# Gene name","Ensembl ID","Chromosome","Start","Stop","Length","Type"]].concat(Object.values(n)),r=t.annotDescriptions.headers+"\n#\n"+e.map((t=>t.join("\t"))).join("\n"),o="data:text/plain;charset=utf-8,"+encodeURIComponent(r);var i=new MouseEvent("click",{view:window,bubbles:!1,cancelable:!0}),a=document.createElement("a");a.setAttribute("download","ideogram.tsv"),a.setAttribute("href",o),a.setAttribute("target","_blank"),a.setAttribute("id","_ideo-undisplayed-dl-annots-link"),a.setAttribute("style","display: none;"),document.body.appendChild(a),a.dispatchEvent(i)}function Pc(){var t=this,n=t.config;!function(t){var n,e=t.config;e.annotationHeight||("heatmap"===e.annotationsLayout?n=e.chrWidth-1:(n=Math.round(e.chrHeight/100))<3&&(n=3),t.config.annotationHeight=n)}(t),n.annotationsPath||n.localAnnotationsPath||t.annots||n.annotations?function(t,n){n.annotationTracks?t.config.numAnnotTracks=n.annotationTracks.length:n.annotationsNumTracks?t.config.numAnnotTracks=n.annotationsNumTracks:t.config.numAnnotTracks=1,t.config.annotTracksHeight=n.annotationHeight*n.numAnnotTracks,void 0===n.barWidth&&(t.config.barWidth=3)}(t,n):(t.config.annotTracksHeight=0,t.config.numAnnotTracks=0),void 0===n.annotationsColor&&(t.config.annotationsColor="#F00"),n.onClickAnnot&&(t.onClickAnnotCallback=n.onClickAnnot),function(t,n){!1!==n.showAnnotTooltip&&(t.config.showAnnotTooltip=!0),n.onWillShowAnnotTooltip&&(t.onWillShowAnnotTooltipCallback=n.onWillShowAnnotTooltip),n.onDidShowAnnotTooltip&&(t.onDidShowAnnotTooltipCallback=n.onDidShowAnnotTooltip)}(t,n),function(t,n){!1!==n.addAnnotLabel&&(t.config.addAnnotLabel=!0),n.onWillAddAnnotLabel&&(t.onWillAddAnnotLabelCallback=n.onWillAddAnnotLabel)}(t,n)}function Dc(){var t=this,n=t.config;t.rawAnnots.annots=t.rawAnnots.annots.sort(Ideogram.sortChromosomes),t.onLoadAnnotsCallback&&t.onLoadAnnotsCallback(),("heatmapThresholds"in n||"metadata"in t.rawAnnots&&"heatmapThresholds"in t.rawAnnots.metadata)&&("heatmap"===n.annotationsLayout?function(t){var n,e,r,o,i,a,s=t.config.heatmapThresholds;for(r=[],e=(i=t.rawAnnots).keys.slice(3),o=[],a=[],!i.metadata&&isNaN(s[0])||(s=Ls(t)),n=0;n<e.length;n++)r.push({key:e[n],thresholds:s}),o.push({id:e[n]}),a.push(n+1);t.config.annotationsNumTracks=e.length,t.config.annotationsDisplayedTracks=a,t.config.heatmaps=r,t.config.annotationTracks=o}(t):"heatmap-2d"===n.annotationsLayout&&(t.config.heatmapThresholds=Ls(t))),n.heatmaps&&t.deserializeAnnotsForHeatmap(t.rawAnnots),function(t){const n={},e=[],r=t.rawAnnots.annots.map((t=>t.chr));if(r.forEach((t=>{t in n&&e.push(t),n[t]=1})),e.length>0)throw Error(`Duplicate chromosomes detected.\nChromosome list: ${r}.  Duplicates: ${e}.\nTo fix this, edit your raw annotations JSON data to remove redundant chromosomes.`)}(t)}function Bc(){return this.annots.reduce(((t,n)=>[...t,...n.annots]),[])}function Fc(t){var n,e=this,r=e.config;n="heatmap-2d"===r.annotationsLayout;var o=function(t){var n,e;return e=(n=t.split("?")[0].split("."))[n.length-1],!1===["bed","json","tsv"].includes(e)?(e=e.toUpperCase(),void alert("Ideogram.js only supports BED and Ideogram JSON and TSV at the moment.  Sorry, check back soon for "+e+" support!")):e}(t);"http"===t.slice(0,4)||n||"tsv"===o?(o=n?"":o,e.fetch(t,"text").then((function(t){e.rawAnnotsResponse=t,n?new Nc(t,e).setRawAnnots().then((function(t){e.rawAnnots=t,e.afterRawAnnots()})):(e.rawAnnots="tsv"===o?new Cs(t,e).rawAnnots:"bed"===o?new As(t,e).rawAnnots:JSON.parse(t),e.afterRawAnnots())}))):e.fetch(t).then((function(t){e.rawAnnotsResponse=t,e.rawAnnots=t,e.afterRawAnnots()}))}function Ic(t){var n,e,r,o,i,a,s;for(n=[],e=[],r=this.chromosomesArray,o=0;o<r.length;o++)i=r[o].name,e.push(i),n.push({chr:i,annots:[]});for(o=0;o<t.length;o++)a=t[o],-1!==(s=e.indexOf(a.chr))&&(n[s]=a);return n}function $c(t,n){if("geneCache"in n==0)return t;const e=n.geneCache.interestingNames;return t.map((t=>(e.includes(t.name)?t.rank=e.indexOf(t.name)+1:t.rank=1e10,t)))}function Gc(t,n="red"){const e=this,r=e.config.taxid,o=t.map((t=>{const o=e.chromosomes[r][t].id,i=`${e.selector} #${o}-chromosome-set`,a=document.querySelector(i),s=a.getBoundingClientRect();return`<rect class="ideo-highlight" id="ideo-highlight-${o}" style="\n      stroke-width: 1px;\n      stroke: ${n};\n      fill: ${n};\n      fill-opacity: 0.05;\n      position: absolute;\n      rx: 4;\n      ry: 4;\n      height: ${s.width+15}px;\n      width: ${s.height+15}px" transform="rotate(90) translate(10, ${a.transform.baseVal[1].matrix.f-7.5})"/>`})).join();document.querySelector(e.selector).insertAdjacentHTML("afterBegin",o)}function Rc(t){const n=this;let e=`${n.selector} .ideo-highlight`;if(void 0!==t){const r=n.config.taxid;e=t.map((t=>{const e=n.chromosomes[r][t].id;return`${n.selector} #ideo-highlight-${e}`}))}document.querySelectorAll(e).forEach((t=>{t.remove()}))}function Oc(t,n){var e,r;return e=n.esearch+"&db=taxonomy&term="+t,Wi.json(e).then((function(n){if(0===n.esearchresult.idlist.length)throw'Organism "'+t+"\" is generally unknown; it was not found in the NCBI Taxonomy database.  If you did not intend to specify a novel or custom taxon, then try using the organism's scientific name, e.g. Homo sapiens or Arabidopsis thaliana.";return r=n.esearchresult.idlist[0],[t,r]}))}function jc(t,n){var e,r,o=this;t=o.config.organism,r=o.esummary+"&db=taxonomy&id="+t,Wi.json(r).then((function(r){return e=r.result[String(t)].commonname,o.config.organism=e,n(e)}))}function Hc(t,n,e){var r,o,i,a,s,c=e.config;(function(t,n){var e,r,o;if(n.assemblyIsAccession())return new Promise((function(e){n.coordinateSystem="bp",n.getAssemblyAndChromosomesFromEutils(t,e)}));e=n.config.dataDir,r=oa(n.organisms[t].scientificName),o=[t],["9606","10090","10116"].includes(t)&&!n.config.showFullyBanded&&(r+="-no-bands");var i=e+r+".json",a=new Promise(((t,n)=>Xi(i).then((n=>n.json().then((function(n){t(n)})))).catch((t=>{n(t)}))));return a.then((function(e){var r,i,a,s,c=e.chrBands,l=[""],u=[],h={};n.bandData[e.taxid]=c;for(var f=0;f<c.length;f++)r=(a=c[f].split(" "))[0],s=a.slice(-1)[0],r in h||(u.push({name:r,type:"nuclear",length:s}),h[r]=1);return u=u.sort(Ideogram.sortChromosomes),i={bp:0,iscn:0},u.forEach((t=>{t.length>i.bp&&(i.bp=t.length)})),n.maxLength[t]=i,l.push(u),l.push(o),l}),(function(){return new Promise((function(e){n.coordinateSystem="bp",n.getAssemblyAndChromosomesFromEutils(t,e)}))}))})(t,e).then((function(l){r=l[0],o=l[1],"chromosomes"in c==0||null===c.chromosomes?(e.config.chromosomes={},e.config.chromosomes[t]=o):(c.multiorganism?t in c.chromosomes?i=c.chromosomes[t]:(a=oa(e.getScientificName(t)),e.config.chromosomes[t]=c.chromosomes[a].slice(),i=e.config.chromosomes[t]):i=c.chromosomes,s=o.filter((t=>i.includes(t.name))),e.config.chromosomes[t]=s),e.chromosomes[t]=e.config.chromosomes[t].slice(),e.organisms[t].assemblies={default:r},n()}))}function qc(t,n){var e,r;for(e in n.organisms)if(r=n.organisms[e],e===oa(t)||oa(r.commonName)===oa(t)||oa(r.scientificName)===oa(t))return!0;return!1}function zc(t,n){(function(t){var n,e,r,o,i,a=t.config;return n=[],e={},function(t,n){var e,r,o,i=[],a={};for(o=0;o<t.length;o++)r=!1===qc(e=t[o],n)?Oc(e,n).then((function(t){var e,r,o=t[1];r=(e=t[0].replace("-"," "))[0].toUpperCase()+e.slice(1),a[o]={scientificName:r,commonName:"",assemblies:{default:""}},Object.assign(n.organisms,a)}),(function(t){console.warn(t);var r={scientificName:e,commonName:e,assemblies:{default:""}};n.organisms[-1]=r,a[-1]=r})):new Promise((function(t){var r=n.getTaxid(e);a[r]=n.organisms[r],t()})),i.push(r);return Promise.all(i).then((function(){return a}))}(a.multiorganism?a.organism:[a.organism],t).then((function(t){var s=t[o];for(o in t)s=t[o],n.push(o),a.multiorganism&&(void 0!==a.chromosomes?(i=Object.keys(a.chromosomes).map((t=>oa(t))),i.includes(oa(s.scientificName))?r=s.scientificName:i.includes(oa(s.commonName))&&(r=s.commonName),oa(r)in a.chromosomes?e[o]=a.chromosomes[oa(r)]:e[o]=a.chromosomes[r.toLowerCase()]):e=null);return[e,n]}))})(n).then((function([e,r]){var o,i,a,s,c,l=n.config,u=[];for(o=0;o<r.length;o++)i=r[o],s=n.organisms[i].assemblies,c=Object.values(s),""===s.default||n.assemblyIsAccession()&&!c.includes(l.assembly)?a=new Promise((function(t){Hc(i,t,n)})):(n.config.taxids=r,n.config.multiorganism&&(n.config.chromosomes=e),a=new Promise((function(t){t()}))),u.push(a);Promise.all(u).then((function(){return r=function(t){var n,e,r;if(n=t.config.organism,e=[],Array.isArray(n))for(r=0;r<n.length;r++)e.push(t.getTaxid(n[r]));else e.push(t.getTaxid(n));return e}(n),n.config.taxids=r,t(r)}))}))}function Wc(t){var n,e=this;if(n="taxid"in e.config,e.config.multiorganism=function(t,n){return"organism"in n.config&&n.config.organism instanceof Array||t&&n.config.taxid instanceof Array}(n,e),e.config.multiorganism&&(e.coordinateSystem="bp"),"organism"in e.config){const n=e.config.organism;"string"==typeof n&&(e.config.organism=oa(n.toLowerCase())),zc(t,e)}else!function(t,n,e){var r;e.config.multiorganism?t&&(r=e.config.taxid):(t&&(r=[e.config.taxid]),e.config.taxids=r),n(r)}(n,t,e)}function Uc(t,n){var e,r;return[e,r]=function(t,n){var e=t.genome;return"mitochondrion"===e?function(t,n){var e,r;return n.config.showNonNuclearChromosomes?(e=t.genome,[-1===(r=t.subtype.split("|").indexOf("plasmid"))?"MT":t.subname.split("|")[r],e]):[null,null]}(t,n):"chloroplast"===e||"plastid"===e?function(t){return t.config.showNonNuclearChromosomes?["CP","chloroplast"]:[null,null]}(n):"apicoplast"===e?function(t){return t.config.showNonNuclearChromosomes?["AP","apicoplast"]:[null,null]}(n):function(t){var n,e;return n=t.subtype.split("|").indexOf("chromosome"),void 0!==(e=t.subname.split("|")[n])&&"chr"===e.substr(0,3)&&(e=e.substr(3)),[e,"nuclear"]}(t)}(t,n),{name:e,length:t.slen,type:r}}function Yc(t,n){var e,r=this,o=function(t,n){var e;return e=n.assemblyIsAccession()?n.config.assembly+"%22[Assembly%20Accession]":t+"%22[taxid]AND%20(%22latest%20refseq%22[filter])%20",n.esearch+"&db=assembly&term=%22"+e+"AND%20(%22chromosome%20level%22[filter]%20OR%20%22complete%20genome%22[filter])"}(t,r);Wi.json(o).then((function(t){return function(t,n){var e,r;return e=t.esearchresult.idlist[0],r=n.esummary+"&db=assembly&id="+e,Wi.json(r)}(t,r)})).then((function(t){var n=t.result.uids[0];return e=t.result[n],function(t,n){var e;return e="&db=nuccore&dbfrom=assembly&linkname=assembly_nuccore&cmd=neighbor_history&from_uid="+t,Wi.json(n.elink+e).then((function(t){var r=t.linksets[0].webenv;return e="&db=nuccore&term=%231+AND+%28sequence_from_chromosome[Properties]+OR+sequence_from_plastid[Properties]+OR+sequence_from_mitochondrion[Properties]%29&WebEnv="+r+"&usehistory=y&retmax=1000",n.esearch+e}))}(n,r)})).then((function(t){return Wi.json(t)})).then((function(t){return function(t,n){var e,r;return e=t.esearchresult.idlist.join(","),r=n.esummary+"&db=nucleotide&id="+e,Wi.json(r)}(t,r)})).then((function(o){var i=function(t,n,e){var r,o,i,a,s={},c=[];for(r in t)"uids"!==r&&(i=(o=Uc(t[r],e)).name+"_"+o.length,null!==o.type&&i in s==0&&c.push(o),s[i]=1);return c=c.sort(Ideogram.sortChromosomes),a={bp:0,iscn:0},c.forEach((t=>{t.length>a.bp&&(a.bp=t.length)})),a.bp>e.maxLength.bp&&(e.maxLength.bp=a.bp),e.maxLength[n]=a,e.coordinateSystem="bp",c}(o.result,t,r);return n([e,i])}),(function(t){console.warn(t)}))}function Xc(){var t=this,n=t.bandsToShow.join(",");0!==t.bandsToShow.length&&(Wi.selectAll(t.selector+" .bandLabel, .bandLabelStalk").style("display","none"),Wi.selectAll(n).style("display",""))}function Vc(t,n,e,r,o){return n!==e&&(t=r[o.id][e]+36),t}function Qc(t,n,e,r,o,i,a){var s,c;return e<r+(a?n:o)?(n=o,s=i,c=a):t.push(i),[t,n,s,c]}function Jc(t,n){var e,r,o,i,a,s=[],c=t[n.id].length,l=0;for(e=0;e<c;e++)o=t[n.id][e],[s,l,r,a]=Qc(s,l,o,5,i,e,!0),a||(i=Vc(i,r,e,t,n),[s,l,r,a]=Qc(s,l,o,5,i,e,!1));return s}function Kc(t,n){var e,r,o,i,a,s,c,l=this;for(l.bandsToShow=[],r=0;r<t.length;r++){for(s=[],c=(i=Jc(n,a=t[r])).length,o=0;o<c;o++)e=i[o],s.push("#"+a.id+" .bsbsl-"+e);l.bandsToShow=l.bandsToShow.concat(s)}}function Zc(t,n,e,r){var o=this,i=o._layout,a=e.chrIndex;return t.selectAll("text").data(n).enter().append("g").attr("class",(function(t,n){return"bandLabel bsbsl-"+n})).attr("transform",(function(t){var n=i.getChromosomeBandLabelTranslate(t,a);return"horizontal"===o.config.orientation?r[e.id].push(n.x+13):r[e.id].push(n.y+6),n.translate})).append("text").attr("text-anchor",i.getChromosomeBandLabelAnchor(a)).text((function(t){return t.name})),r}function tl(t,n,e,r){var o=this;t.selectAll("line.bandLabelStalk").data(n).enter().append("g").attr("class",(function(t,n){return"bandLabelStalk bsbsl-"+n})).attr("transform",(function(t){var n;return n=o.round(t.px.start+t.px.width/2),r[e.id].push(n+13),"translate("+n+",-10)"})).append("line").attr("x1",0).attr("y1",o._layout.getChromosomeBandTickY1(e.chrIndex)).attr("x2",0).attr("y2",o._layout.getChromosomeBandTickY2(e.chrIndex))}function nl(t){var n,e,r,o,i,a=this,s={};for(o=function(t){var n,e,r=[];for(n in t)for(e in t[n])r.push(t[n][e]);return r}(t),n=0;n<o.length;n++)r=o[n],e=Wi.select(a.selector+" #"+r.id),s[r.id]=[],i=r.bands.filter((t=>"pter"!==t.name)),s=a.drawBandLabelText(e,i,r,s),a.drawBandLabelStalk(e,i,r,s);a.setBandsToShow(o,s)}function el(t,n){return[n[t][0],n[t][1],n[t][2],n[t][3]]}function rl(){var t="";return t=function(t){var n,e,r,o,i,a="";for(n=0;n<t.length;n++)[e,r,o,i]=el(n,t),a+='<linearGradient id="'+e+'" x1="0%" y1="0%" x2="0%" y2="100%">',a+="gneg"===e?'<stop offset="70%" stop-color="'+o+'" /><stop offset="95%" stop-color="'+i+'" /><stop offset="100%" stop-color="'+r+'" />':'<stop offset="5%" stop-color="'+r+'" /><stop offset="15%" 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il(t,n,e,r){var o,i,a=r.config.multiorganism;return null!=t&&(i=(o=Array.isArray(t))&&-1===t.indexOf(n),!(!o||"object"==typeof t||!i)||(e in t!=0||!a)&&(a?"string"==typeof t[e][0]?!1===t[e].includes(n):0===t[e].filter((t=>t.name===n)).length:0===t.filter((t=>t===n)).length))}function al(t,n,e,r){var o,i,a=[];return o=n[t],a.push(o),i={iscn:o[o.length-1].iscn.stop,bp:o[o.length-1].bp.stop},e in r.maxLength==0&&(r.maxLength[e]={bp:0,iscn:0}),i.iscn>r.maxLength[e].iscn&&(r.maxLength[e].iscn=i.iscn,i.iscn>r.maxLength.iscn&&(r.maxLength.iscn=i.iscn)),i.bp>r.maxLength[e].bp&&(r.maxLength[e].bp=i.bp,i.bp>r.maxLength.bp&&(r.maxLength.bp=i.bp)),a}function sl(t,n,e,r){var o,i;if(t in r.bandData||t in zi&&!1===r.assemblyIsAccession())e=function(t,n,e,r){var o,i,a;o=function(t,n,e){var r,o,i,a,s,c,l={};c=e.bandData[t],Array.isArray(c)&&(s="native"),n=function(t){var n,e;if(t instanceof Array&&"object"==typeof t[0]){for(n=[],e=0;e<t.length;e++)n.push(t[e].name);t=n}return t}(n);var 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n=t.map(i.invert),e=Math.floor(n[0]),r=Math.ceil(n[1]);o.selectedRegion={from:e,to:r,extent:r-e},o.onBrushMoveCallback&&o.onBrushMoveCallback()})).on("end",(function({selection:t}){o.onBrushEndCallback&&o.onBrushEndCallback()}))}(i,a,l,c,s),function(t,n,e){var r=n-t+1;e.selectedRegion={from:t,to:n,extent:r}}(n,e,s),function(t,n,e,r,o,i){var a,s,c;a=i.convertBpToPx(t,n)+r,s=i.convertBpToPx(t,e)+r,c=i._layout.getChromosomeSetYTranslate(0)+(i.config.chrWidth-o)/2,Wi.select(i.selector).append("g").attr("class","brush").attr("transform","translate(0, "+c+")").call(i.brush).call(i.brush.move,[a,s])}(r,n,e,l,c,s)}function fl(){call(this.onCursorMoveCallback)}function dl(t){var n,e,r,o=this,i=o.config.chrWidth+6.5,a=o._layout.margin.left;if(void 0===t)return!1;n=function(t,n){var e,r;for(e=0;e<n.chromosomesArray.length;e++)if((r=n.chromosomesArray[e]).name===t)return r}(o.config.chromosome,o),[e,r]=function(t,n){var e,r,o=[1],i=[1],a=t.bands.slice(-1)[0];for(r=0;r<t.bands.length;r++)e=t.bands[r],o.push(e.bp.start),i.push(e.px.start+n);return o.push(a.bp.stop-1),i.push(a.px.stop+n),[o,i]}(n,a),function(t,n,e,r,o,i){var a;a=Wi.scaleLinear().domain(n).range(e),"rotatable"in i.config&&!1===i.config.rotatable||console.warn("Using the cursor with rotate is not supported.");var s=i._layout.getChromosomeSetYTranslate(0)+(i.config.chrWidth-o)/2,c=Wi.select(i.selector).append("g").attr("class","brush").attr("transform","translate(0, "+s+")").append("rect").attr("class","cursor").attr("x",a(t)).attr("y",0).attr("width",1).attr("height",30);i.onCursorMove&&i.onCursorMoveCallback(t),i.setCursorPosition||(i.setCursorPosition=function(t){c.attr("x",a(t)),i.onCursorMove&&i.onCursorMoveCallback(t)}),Wi.selectAll(i.selector+" .chromosome").on("click",(function(t){var n=t.offsetX;n-=6,c.attr("x",n);var e=Math.floor(a.invert(n));i.onCursorMove&&i.onCursorMoveCallback(e)}))}(t,e,r,0,i,o)}function ml(t,n){var 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this._config.armColors?this._config.armColors[e]:this._config.ancestors?this._getPolyploidArmColor(t,n,e):null}getBorderColor(t,n,e){const r=this._config,o=r.chrBorderColor?r.chrBorderColor:"#000";return n<r.ploidy||this._ploidy.exists(t,n,e)?o:"#fff"}getFillColor(){const t=this._config;if(!t.chrFillColor)return"#AAA";const n=t.chrFillColor;return"string"==typeof n?{arm:n,centromere:""}:n}_getPolyploidArmColor(t,n,e){if(this._ploidy.exists(t,n,e)){var r=this._ploidy.getAncestor(t,n,e);return this._config.ancestors[r]}return"transparent"}}class yu{constructor(t){this._data=t,this.start=t.start,this.stop=t.stop,this.length=this.stop-this.start}getColor(t){return"ploidy"in this._data?"ploidy"in this._data&&this._data.ploidy[t]?this._getColor(t):"transparent":this._getColor(t)}_getColor(t){return Array.isArray(this._data.color)?this._data.color[t]:this._data.color}}class vu{constructor(t,n,e){this._adapter=t,this._model=this._adapter.getModel(),this._config=n,this._ideo=e,this._color=new gu(this._config),this._bumpCoefficient=5}static getInstance(t,n,e){const r=t.getModel().centromerePosition;return"telocentric-p"===r?new wu(t,n,e):"telocentric-q"===r?new _u(t,n,e):new bu(t,n,e)}_addPArmShape(t,n){return n?t.concat(this._getPArmShape()):t}_addQArmShape(t,n){return n?t.concat(this._getQArmShape()):t}render(t,n,e){var r,o,i,a,s,c,l;let u;if(r=this,t=t.append("g").attr("class","bands").attr("clip-path","url(#"+this._model.id+"-chromosome-set-clippath)"),o=this._renderArm(t,n,e,"p"),i=this._renderArm(t,n,e,"q"),this._renderRangeSet(t,n,e),a=[],a=this._addPArmShape(a,o),a=this._addQArmShape(a,i),s="0",c="",l=this.isFullyBanded(),"ancestors"in this._ideo.config&&!("rangeSet"in this._ideo.config)?(c=r._color.getArmColor(n,e,0),l&&(s="0.5")):l?(s=null,c="transparent"):"ancestors"in this._ideo.config||(s="1"),this._ideo.config.chrFillColor){const t=r._color.getFillColor();c=t.arm,u=t.centromere}return t.append("g").attr("class","chromosome-border").selectAll("path").data(a).enter().append("path").attr("fill",c).style("fill-opacity",s).style("fill",(function(t){if("acen"===t.class&&u)return u})).attr("stroke",(function(t,o){return r._color.getBorderColor(n,e,o)})).attr("stroke-width",(function(t){return"strokeWidth"in t?t.strokeWidth:1})).attr("d",(function(t){return t.path})).attr("class",(function(t){return t.class})),a}_renderRangeSet(t,n,e){var r,o,i,a;"rangeSet"in this._config&&(o=this._config.rangeSet.filter((function(t){return t.chr-1===n})).map((function(t){return new yu(t)})),i=t.append("g").attr("class","range-set"),a=(r=this)._ideo,i.selectAll("rect.range").data(o).enter().append("rect").attr("class","range").attr("x",(function(t){return a.convertBpToPx(r._model,t.start)})).attr("y",0).attr("width",(function(t){return a.convertBpToPx(r._model,t.length)})).attr("height",this._config.chrWidth).style("fill",(function(t){return t.getColor(e)})))}_getShapeData(){var t,n,e,r;for(n=0;n<this._model.bands.length;n++)if("q"===this._model.bands[n].name[0]){t=this._model.bands[n];break}return e=this._model.bands.length-1,r=this._model.bands[e].px.stop,{x1:0,x2:t?t.px.start:r,x3:r,w:this._config.chrWidth,b:this._config.chrWidth/this._bumpCoefficient}}_getPArmShape(){var t=this._getShapeData(),n=t.x2-t.b;return this.isFullyBanded()||"ancestors"in this._ideo.config?{class:"",path:"M"+t.b+",0 L"+n+",0 Q"+(t.x2+t.b)+","+t.w/2+","+n+","+t.w+" L"+t.b+","+t.w+" Q-"+t.b+","+t.w/2+","+t.b+",0"}:[{class:"",path:"M"+t.b+",0 L"+(n-2)+",0 L"+(n-2)+","+t.w+" L"+t.b+","+t.w+" Q-"+t.b+","+t.w/2+","+t.b+",0"},{class:"acen",path:"M"+n+",0 Q"+(t.x2+t.b)+","+t.w/2+","+n+","+t.w+" L"+n+","+t.w+" L"+(n-2)+","+t.w+" L"+(n-2)+",0"}]}_getQArmShape(){var t=this._getShapeData(),n=t.x3-t.b,e=t.x2+t.b;return this.isFullyBanded()||"ancestors"in this._ideo.config?{class:"",path:"M"+e+",0 L"+n+",0 Q"+(t.x3+t.b)+","+t.w/2+","+n+","+t.w+" L"+e+","+t.w+" Q"+(t.x2-t.b)+","+t.w/2+","+e+",0"}:[{path:"M"+e+",0 L"+n+",0 Q"+(t.x3+t.b)+","+t.w/2+","+n+","+t.w+" L"+e+","+t.w+" L"+e+",0"},{class:"acen",path:"M"+e+",0Q"+(t.x2-t.b)+","+t.w/2+","+e+","+t.w+" L"+e+","+t.w+"L"+(e+2)+","+t.w+"L"+(e+2)+",0"}]}isFullyBanded(){return this._model.bands&&(2!==this._model.bands.length||"q"===this._model.bands[0].name[0])}_renderBands(t,n,e,r,o){var i,a,s;a="p"===o?0:1,s="","ancestors"in(i=this)._ideo.config&&!i.isFullyBanded()&&(s=i._color.getArmColor(n,e,a)),t.selectAll("path.band."+o).data(r).enter().append("path").attr("id",(function(t){return i._model.id+"-"+t.name.replace(".","-")})).attr("class",(function(t){return"band "+o+"-band "+t.stain})).attr("d",(function(t){var n;return"M "+i._ideo.round(t.px.start)+", 0l "+(n=i._ideo.round(t.px.width))+" 0 l 0 "+i._config.chrWidth+" l -"+n+" 0 z"})).style("fill",s)}_renderArm(t,n,e,r){var o=this._model.bands.filter((function(t){return t.name[0]===r}));return this._renderBands(t,n,e,o,r),Boolean(o.length)}}class bu extends vu{constructor(t,n,e){super(t,n,e),this._class="MetacentricChromosome"}}class wu extends vu{constructor(t,n,e){super(t,n,e),this._class="TelocentricPChromosome",this._pArmOffset=3}_addPArmShape(t){return t.concat(this._getPArmShape())}_getPArmShape(){var t=this._getShapeData();return t.o=this._pArmOffset,[{class:"acen",path:"M"+(t.x2+2)+",1L"+(t.x2+t.o+3.25)+",1 L"+(t.x2+t.o+3.25)+","+(t.w-1)+" L"+(t.x2+2)+","+(t.w-1)},{class:"gpos66",path:"M"+(t.x2-t.o+5)+",0L"+(t.x2-t.o+3)+",0 L"+(t.x2-t.o+3)+","+t.w+" L"+(t.x2-t.o+5)+","+t.w,strokeWidth:.5}]}_getQArmShape(){var t=this._getShapeData(),n=t.x3-t.b,e=this._pArmOffset+3;return{class:"",path:"M"+(t.x2+e)+",0 L"+n+",0 Q"+(t.x3+t.b)+","+t.w/2+","+n+","+t.w+" L"+(t.x2+e)+","+t.w}}}class _u extends vu{constructor(t,n,e){super(t,n,e),this._class="TelocentricQChromosome",this._qArmOffset=3}_getPArmShape(){var t=this._getShapeData(),n=t.x3-t.b,e=this._qArmOffset;return{class:"",path:"M"+(t.x2+e)+",0 L"+(n+e)+",0 L"+(n+e)+","+t.w+" L"+t.b+","+t.w+" Q-"+t.b+","+t.w/2+","+t.b+",0"}}_addQArmShape(t){return t.concat(this._getQArmShape())}_getQArmShape(){var t=this._getShapeData();return t.o=this._qArmOffset,[{class:"acen",path:"M"+(t.x2+2)+",1 L"+(t.x2+t.o+3.25)+",1 L"+(t.x2+t.o+3.25)+","+(t.w-1)+" L"+(t.x2+2)+","+(t.w-1)},{class:"gpos66",path:"M"+(t.x2+t.o+5)+",0 L"+(t.x2+t.o+3)+",0 L"+(t.x2+t.o+3)+","+t.w+" L"+(t.x2+t.o+5)+","+t.w,strokeWidth:.5}]}}function xu(t,n,e,r){var o,i,a,s,c;s=Wi.select(this.selector+" defs"),c=mu.getInstance(t),o=e*this.config.chrMargin,i=r.append("g").attr("id",t.id).attr("class","chromosome "+c.getCssClass()).attr("transform","translate(0, "+o+")"),a=vu.getInstance(c,this.config,this).render(i,n,e),Wi.select("#"+t.id+"-chromosome-set-clippath").remove(),s.append("clipPath").attr("id",t.id+"-chromosome-set-clippath").selectAll("path").data(a).enter().append("path").attr("d",(function(t){return t.path})).attr("class",(function(t){return t.class})),t.width<1&&Wi.select("#"+t.id+" .bands").style("opacity",0)}function Au(t){var n,e,r,o,i,a;if(n=t.chrIndex,o=this._layout.getChromosomeSetTranslate(n),a=this.selector+" #"+t.id+"-chromosome-set",Wi.selectAll(a+" g").remove(),0===(e=Wi.select(a)).nodes().length&&(e=Wi.select(this.selector).append("g").attr("class","chromosome-set").attr("transform",o).attr("id",t.id+"-chromosome-set")),"sex"in this.config&&2===this.config.ploidy&&this.sexChromosomes.index===n)this.drawSexChromosomes(e,n);else for(r=1,this.config.ploidy>1&&(r=this._ploidy.getChromosomesNumber(n)),i=0;i<r;i++)this.appendHomolog(t,n,i,e)}function Cu(t){var n,e;this.unhighlight(),this.config.taxid&&(n=t.id.split("-")[0].replace("chr",""),e=this.chromosomes[this.config.taxid][n].chrIndex,this._layout.rotate(e,e,t))}function Su(){var t,n,e,r,o,i,a,s;n=(t=this).config,i=Wi.select(n.container+" svg#_ideogram"),r=Wi.select(n.container+" #_ideogramInnerWrap"),o=Wi.select(n.container+" #_ideogramMiddleWrap"),s=1===(a=n.ploidy)?a:1.12*a;let c=0;"annotationsLayout"in n&&(c=n.annotationHeight*n.numAnnotTracks),"vertical"===n.orientation&&"comparative"!==n.perspective&&"collinear"!==n.geometry&&(e=t.numChromosomes*(n.chrWidth+n.chrMargin+c),"heatmap-2d"!==n.annotationsLayout&&(e=Math.ceil(e*s/n.rows),"SmallLayout"===t._layout._class&&(e+=100),e+=35,o.style("height",t._layout.getHeight()+"px"),r.style("max-width",e+"px").style("overflow-x","scroll").style("position","absolute"),i.style("min-width",e-5+"px"),t.config.showTools&&du(t)))}function ku(){(function(t){var n=t._layout;Wi.selectAll(t.selector+" .chromosome-set").insert("text",":first-child").data(t.chromosomesArray).attr("class",n.getChromosomeLabelClass()).attr("transform",n.getChromosomeSetLabelTranslate()).attr("x",n.getChromosomeSetLabelXPosition()).attr("y",(function(t,e){return n.getChromosomeSetLabelYPosition(e)})).attr("text-anchor",n.getChromosomeSetLabelAnchor()).each((function(n,e){!function(t,n,e,r){var o=function(t,n,e){var r;return r=-1===t.name.indexOf(" ")?[t.name]:t.name.match(/^(.*)\s+([^\s]+)$/).slice(1).reverse(),"sex"in e.config&&2===e.config.ploidy&&n===e.sexChromosomes.index&&(r="male"===e.config.sex?["XY"]:["XX"]),r}(t,n,r);Wi.select(e).selectAll("tspan").data(o).enter().append("tspan").attr("dy",(function(t,n){return-1.2*n+"em"})).attr("x",r._layout.getChromosomeSetLabelXPosition()).attr("class",(function(t,n){var e=r.config.fullChromosomeLabels;return 1===n&&e?"italic":null})).text(String)}(n,e,this,t)}))})(this),function(t){var n=t._layout;Wi.selectAll(t.selector+" .chromosome-set").each((function(e,r){Wi.select(this).selectAll(".chromosome").append("text").attr("class","chrLabel").attr("transform",n.getChromosomeSetLabelTranslate()).attr("x",(function(t,e){return n.getChromosomeLabelXPosition(e)})).attr("y",(function(t,e){return n.getChromosomeLabelYPosition(e)})).text((function(n,e){return t._ploidy.getAncestor(r,e)})).attr("text-anchor","middle")}))}(this)}function Tu(t,n,e,r){var o;n-=1,o=function(t){var n,e,r;return void 0===t||!t.hasOwnProperty("x")||1===t.x&&1===t.y?(n=-8,e=-16,t={x:1,y:1},r=""):(r="scale("+t.x+","+t.y+")",n=-6,e=""===t?-16:-14),{x:n,y:e,scaleSvg:r,scale:t}}(r),"vertical"===e||""===e?function(t,n,e,r){var o,i,a,s=r.config;n=function(t,n){return(n.numAnnotTracks>1||""===n.orientation)&&(t-=1),t}(n,s),o=-4,!0===s.showBandLabels&&(o=s.chrMargin+s.chrWidth+26),i=s.chrMargin*n,s.numAnnotTracks>1==0&&(i+=1),a=i+o,t.selectAll("text.chrLabel").attr("transform",e.scaleSvg).selectAll("tspan").attr("x",e.x).attr("y",a)}(t,n,o,this):function(t,n,e,r){var o,i,a,s=r.config;o=-s.chrWidth-2,!0===s.showBandLabels&&(o=s.chrMargin+8),i=s.annotTracksHeight,"overlay"!==s.annotationsLayout&&(i*=2),a=3-(s.chrMargin*n+o)+i,a/=e.scale.x,t.selectAll("text.chrLabel").attr("transform","rotate(-90)"+e.scaleSvg).selectAll("tspan").attr("x",a).attr("y",e.y)}(t,n,o,this)}function Lu(t){return Math.round(performance.now()-t)}function Mu(){const t=this.annotDescriptions.annots,n=Object.values(t).slice(),e=n.filter((t=>t.type&&t.type.includes("paralogous"))),r=n.filter((t=>t.type&&t.type.includes("interacting gene")));return{related:n,paralogous:e,interacting:r,searched:Object.entries(t).filter((t=>t[1].type&&t[1].type.includes("searched gene")))[0][0]}}function Nu(t){const n=this,e=performance.now()-n.time.prevTooltipOff,r=n.time.prevTooltipAnnotDomId;if(e<300&&t.domId===r)return null;const o=t.name,i=n.annotDescriptions.annots[t.name].type.split(" ")[0],a=Eu(n);return Object.assign({tooltipGene:o,tooltipRelatedType:i},a)}function Eu(t){const n=t.getRelatedGenesByType();return{numRelatedGenes:n.related.length,numParalogs:n.paralogous.length,numInteractingGenes:n.interacting.length,searchedGene:n.searched}}const Pu="<span style='color: #CCC'>|</span>",Du="5'-UTR",Bu="3'-UTR",Fu={"5'-UTR":20,exon:20,intron:20,"3'-UTR":20},Iu={"5'-UTR":"#155069",exon:"#DAA521",intron:"#FFFFFF00","3'-UTR":"#357089"},$u={"5'-UTR":"#70A099",exon:"#BA8501","3'-UTR":"#90C0B9"},Gu={"5'-UTR":"five-prime-utr",exon:"exon","3'-UTR":"three-prime-utr",intron:"intron"};function Ru(){return document.querySelector("._ideoGeneStructureFooter")}function Ou(t){const n=Ru(),e=t.querySelector("svg").getAttribute("data-ideo-footer");n.innerHTML=`&nbsp;<br/>${e}`}function ju(t,n=0){const[e,r]=qu(t,n),o=0===r;document.querySelector("#_ideoGeneStructureMenu").options[r].selected=!0;const i=ch(e,t,t.spliceExons)[0],a=document.querySelector("._ideoGeneStructureSvgContainer");a.innerHTML=i,rh(t.spliceExons,o),Ou(a),t.addedSubpartListeners=!1,Zu(t)}function Hu(t){return t.split("-").slice(0,-1).join("-")}function qu(t,n=0){let e,r;const o=document.querySelector("#_ideoGeneStructureMenu");if(o){const t=o.options.length;e=o.selectedIndex+n,e>=t?e=0:e<0&&(e=t-1),r=o.options[e].value}else{const t=document.querySelector("._ideoGeneStructure");if(!t)return null;r=t.getAttribute("data-ideo-gene-structure-name"),e=0}const i=Hu(r);return[t.geneStructureCache[i].find((t=>t.name===r)),e]}function zu(t){if("s"===t.key){const t=document.querySelector("._ideoSpliceToggle input");if(!t)return;const n=document.querySelector("#_ideoSubpartText");n&&(n.innerHTML="&nbsp;"),t.dispatchEvent(new MouseEvent("click"))}}function Wu(t,n){const e=t.slice(),r=n?Bu:Du,o=t.some((t=>t[0]===r));return t.forEach(((r,i)=>{if(0===i)return;const a=t[i-1],s=a[0]===Bu,c=a[0]===Du;"exon"===r[0]&&o&&(!n&&s||n&&c)&&(e[i]=a,e[i-1]=r)})),e}function Uu(t,n){return t.classList.contains(n)}function Yu(t,n,e,r){const o="five-prime-utr",i="three-prime-utr",a=Uu(n,o),s=Uu(n,i),c=!Uu(t,i),l=!Uu(t,o);return r&&(!e&&s&&c||e&&a&&l)}function Xu(t,n,e,r){const o=n[0]===Du,i=n[0]===Bu,a=t[0]!==Bu,s=t[0]!==Du;return r&&(!e&&i&&a||e&&o&&s)}function Vu(){const t="_ideoHoveredSubpart";document.querySelectorAll(`.${t}`).forEach((n=>n.classList.remove(t)))}function Qu(t){const n=Array.from(document.querySelectorAll("rect.subpart")),e="+"===document.querySelector("._ideoGeneStructure").getAttribute("data-ideo-strand"),r=function(t,n){const e=t.slice(),r=Array.isArray(t[0]);let o;if(r){const 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e=document.querySelector("._ideoGeneStructureContainer");e.addEventListener("mouseenter",(()=>{document.addEventListener("keydown",Qu),t.addedMenuListeners||(t.addedMenuListeners=!0,Ou(e),document.querySelector("._ideogramTooltip").addEventListener("change",(()=>{ju(t),t.oneTimeDelayTooltipHideMs=2e3})))})),e.addEventListener("mouseleave",(n=>{t.oneTimeDelayTooltipHideMs=2e3;const e=function(t){const n=document.querySelector("._ideogramTooltip").getBoundingClientRect(),e=t.screenX,r=t.screenY;return e>n.left&&e<n.right&&r>n.top&&r<n.bottom}(n);!0===e&&(Ru().innerHTML=""),t.addedMenuListeners=!1,document.removeEventListener("keydown",Qu)})),t.addedSubpartListeners||(t.addedSubpartListeners=!0,n.forEach((n=>{Ku(n,t)})))}function th(t){null!==qu(t)&&(function(t){document.addEventListener("keydown",zu);const 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t.displayCoordinates=n.displayCoordinates,[t,i]}(t,r)),t.displayName=u,t},onDidShowAnnotTooltip:function(){!function(t){const n=document.querySelector("._ideogramTooltip");t.addedTooltipClickHandler||(n.addEventListener("click",(n=>{if(["input","label"].includes(n.target.localName))return;let e=document.querySelector("#ideo-related-gene");e||(e=n.target);const r=function(t,n){var e;return n.annots.forEach((n=>{n.annots.forEach((n=>{t===n.name&&(e=n)}))})),null===e&&(e=n.annotDescriptions.annots[t]),e}(e.textContent,t);t.onClickAnnot(r)})),t.addedTooltipClickHandler=!0)}(this),th(this)},showTools:!0,showAnnotLabels:!0,chrFillColor:{centromere:"#DAAAAA"}};function Ih(){const t=this;if(!t||"annotDescriptions"in t)return;t.annotDescriptions={annots:{}},t.flattenAnnots().map((n=>{let e=[];"significance"in n&&"n/a"!==n.significance&&e.push(n.significance),"citations"in n&&void 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Gh{constructor(t){this.configure=ha,this.initDrawChromosomes=ds,this.onLoad=ps,this.handleRotateOnClick=ms,this.init=xs,this.finishInit=Za,this.writeContainer=ss,this.onLoadAnnots=js,this.onDrawAnnots=Hs,this.processAnnotData=Mc,this.restoreDefaultTracks=_c,this.updateDisplayedTracks=xc,this.initAnnotSettings=Pc,this.fetchAnnots=Fc,this.drawAnnots=uc,this.getHistogramBars=oc,this.drawHeatmaps=Gs,this.deserializeAnnotsForHeatmap=Os,this.fillAnnots=Ic,this.drawProcessedAnnots=hc,this.drawSynteny=wc,this.startHideAnnotTooltipTimeout=zs,this.showAnnotTooltip=Xs,this.onWillShowAnnotTooltip=Ws,this.onDidShowAnnotTooltip=Us,this.onClickAnnot=Ys,this.setOriginalTrackIndexes=Ac,this.afterRawAnnots=Dc,this.downloadAnnotations=Ec,this.addAnnotLabel=tc,this.removeAnnotLabel=ec,this.fillAnnotLabels=nc,this.clearAnnotLabels=rc,this.flattenAnnots=Bc,this.highlight=Gc,this.unhighlight=Rc,this.esearch="https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?retmode=json&api_key=7e33ac6a08a6955ec3b83d214d22b21a2808",this.esummary="https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?retmode=json&api_key=7e33ac6a08a6955ec3b83d214d22b21a2808",this.elink="https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?retmode=json&api_key=7e33ac6a08a6955ec3b83d214d22b21a2808",this.getOrganismFromEutils=jc,this.getTaxids=Wc,this.getAssemblyAndChromosomesFromEutils=Yc,this.drawBandLabels=nl,this.getBandColorGradients=rl,this.processBandData=cl,this.setBandsToShow=Kc,this.hideUnshownBandLabels=Xc,this.drawBandLabelText=Zc,this.drawBandLabelStalk=tl,this.onBrushMove=ll,this.onBrushEnd=ul,this.createBrush=hl,this.createClickCursor=dl,this.onCursorMove=fl,this.drawSexChromosomes=ml,this.setSexChromosomes=pl,this.convertBpToPx=gl,this.convertPxToBp=vl,this.unpackAnnots=ou,this.packAnnots=iu,this.initCrossFilter=au,this.filterAnnots=su,this.assemblyIsAccession=Ui,this.getDataDir=Vi,this.round=Qi,this.onDidRotate=Ji,this.getSvg=Ki,this.fetch=Zi,this.getTaxid=ta,this.getCommonName=na,this.getScientificName=ea,this.getChromosomeModel=lu,this.getChromosomePixels=cu,this.drawChromosomeLabels=ku,this.rotateChromosomeLabels=Tu,this.appendHomolog=xu,this.drawChromosome=Au,this.rotateAndToggleDisplay=Cu,this.setOverflowScroll=Su,this.plotRelatedGenes=Lh,this.getRelatedGenesByType=Mu,this.configure(t)}static 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o=t.organisms[n].scientificName;Wi.select(t.selector).append("text").attr("class","genomeLabel italic").attr("x",55+200*e).attr("y",10).text(o).attr("text-anchor","middle")}))}(o)}(n,e,-40,t),r=Math.round(e.slice(-1)[0]+70),i.multiorganism){o*=8;var a=0;e.forEach((t=>{t>a&&(a=t)})),o=a+30}else o=xOffsets.slice(-1)[0]+30;Wi.select(t.selector).attr("height",o).attr("width",r),Wi.select("#_ideogramTrackLabelContainer").remove(),Wi.select("#_ideogramInnerWrap").insert("div",":first-child").attr("id","_ideogramTrackLabelContainer").style("position","absolute")};const da=function(t){var n,e,o,r,i,a=t.config,s=a.annotationHeight||0;if("vertical"!==a.orientation){t.config.annotLabelHeight=12;var c=t.config.annotLabelHeight;if("demarcateCollinearChromosomes"in t.config==0&&(t.config.demarcateCollinearChromosomes=!0),n=document.querySelectorAll(".chromosome-set"),o=a.numAnnotTracks*(s+c+4)-a.chrWidth+1,e=function(t,n){var e,o,r,i,a,s,c,l={};for(e=[],o=0;o<t.length;o++)c=n.chromosomesArray[o].id.split("-")[1],r=0===o?o:o-1,i=n.chromosomesArray[r],0===o||c in l==0?(a=20,l[c]=1):(s=i.width,a=e[r]+s+(n.config.showChromosomeLabels?0:2)+n.config.chrMargin),e.push(a);return e}(n,t),function(t,n,e,o){var r,i,a,s,c,l,u,h=o.config,f=h.chrWidth,d=h.chrLabelSize;for(r=0;r<t.length;r++)i=t[r],s=n[r],a=o.chromosomesArray[r].id.split("-")[1],c=e+200*(l=h.taxids.indexOf(a)),0===l&&o.config.multiorganism?(u=d-4,c+=2*f+d):u=2*f+d+2,o.config.showChromosomeLabels&&(i.querySelector(".chrLabel").setAttribute("y",u),i.querySelector(".chrLabel").setAttribute("text-anchor","middle")),i.setAttribute("transform","translate("+s+","+c+")"),i.querySelector(".chromosome").setAttribute("transform","translate(-13, 10)");h.multiorganism&&function(t){t.config.taxids.forEach(((n,e)=>{var o=t.organisms[n],r=t.config,i=o.scientificName;Wi.select(t.selector).append("text").attr("class","genomeLabel 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pa(32768)),Ta=0;Ta<32768;++Ta){var La=(43690&Ta)>>>1|(21845&Ta)<<1;La=(61680&(La=(52428&La)>>>2|(13107&La)<<2))>>>4|(3855&La)<<4,ka[Ta]=((65280&La)>>>8|(255&La)<<8)>>>1}var Ma=function(t,n,e){for(var o=t.length,r=0,i=new pa(n);r<o;++r)t[r]&&++i[t[r]-1];var a,s=new pa(n);for(r=0;r<n;++r)s[r]=s[r-1]+i[r-1]<<1;if(e){a=new pa(1<<n);var c=15-n;for(r=0;r<o;++r)if(t[r])for(var l=r<<4|t[r],u=n-t[r],h=s[t[r]-1]++<<u,f=h|(1<<u)-1;h<=f;++h)a[ka[h]>>>c]=l}else for(a=new pa(o),r=0;r<o;++r)t[r]&&(a[r]=ka[s[t[r]-1]++]>>>15-t[r]);return a},Ea=new ma(288);for(Ta=0;Ta<144;++Ta)Ea[Ta]=8;for(Ta=144;Ta<256;++Ta)Ea[Ta]=9;for(Ta=256;Ta<280;++Ta)Ea[Ta]=7;for(Ta=280;Ta<288;++Ta)Ea[Ta]=8;var Na=new ma(32);for(Ta=0;Ta<32;++Ta)Na[Ta]=5;var Pa=Ma(Ea,9,1),Da=Ma(Na,5,1),Ba=function(t){for(var n=t[0],e=1;e<t.length;++e)t[e]>n&&(n=t[e]);return n},Ia=function(t,n,e){var o=n/8|0;return(t[o]|t[o+1]<<8)>>(7&n)&e},Fa=function(t,n){var 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ns(t){var n=(new Date).getTime(),e=this,o=e.config,r=o.annotations;e.initDrawChromosomes(),o.annotationsPath&&function(t){t.rawAnnots?ts(t):function n(){t.timeout=setTimeout((function(){!t.rawAnnots||t.rawAnnots&&void 0!==t.rawAnnots.then?n():ts(t)}),50)}()}(e),function(t,n){var e,o,r,i;if(!0===t.showBandLabels&&(r=(new Date).getTime(),n.hideUnshownBandLabels(),i=(new Date).getTime(),t.debug&&console.log("Time in showing bands: "+(i-r)+" ms"),"vertical"===t.orientation))for(e=0;e<n.chromosomesArray.length;e++)o="#"+n.chromosomesArray[e].id,n.rotateChromosomeLabels(Wi.select(o),e);!0===t.showChromosomeLabels&&n.drawChromosomeLabels(n.chromosomes)}(o,e),o.brush?e.createBrush(o.brush):o.cursorPosition&&e.createClickCursor(o.cursorPosition),r&&(Array.isArray(r)?e.drawAnnots(r):(e.rawAnnots=r,e.afterRawAnnots(),ts(e))),function(t,n,e){var o=(new Date).getTime();t.debug&&console.log("Time in drawChromosome: "+(o-e)+" ms");var r=(new Date).getTime();t.debug&&console.log("Time constructing ideogram: "+(r-n)+" ms")}(o,t,n),e.setOverflowScroll(),"collinear"===o.geometry&&da(e),e.config.debug&&console.time("initCache: Ideogram"),async function(t){const n=t.config;if(!n.useCache)return;const e=n.organism;let o=null;if(n.cacheDir&&(o=n.cacheDir),n.awaitCache){const r=Promise.all([Za("gene",e,t,o),Za("paralog",e,t,o),Za("interaction",e,t,o)]);return n.showGeneStructureInTooltip&&(Za("geneStructure",e,t,o),Za("protein",e,t,o)),r}Za("gene",e,t,o),Za("paralog",e,t,o),Za("interaction",e,t,o),n.showGeneStructureInTooltip&&(Za("geneStructure",e,t,o),Za("protein",e,t,o))}(e).then((()=>{e.config.debug&&console.timeEnd("initCache: Ideogram"),e.onLoadCallback&&e.onLoadCallback()}))}class es{constructor(t){this._config=t,this._description=this._normalize(this._config.ploidyDesc)}getChromosomesNumber(t){if(this._config.ploidyDesc){var n=this._config.ploidyDesc[t];return n instanceof Object?Object.keys(n)[0].length:n.length}return this._config.ploidy||1}_normalize(t){var n,e,o=[];if(!t)return t;for(n in t)"string"==typeof(e=t[n])?("vertical"===this._config.orientation&&(e=e.split("").reverse()),o.push({ancestors:e,existence:this._getexistenceArray(e.length)})):o.push({ancestors:Object.keys(e)[0],existence:e[Object.keys(e)[0]]});return o}_getexistenceArray(t){for(var n=[],e=0;e<t;e++)n.push("11");return n}getSetSize(t){return this._description?this._description[t].ancestors.length:1}getAncestor(t,n){return this._description?this._description[t].ancestors[n]:""}exists(t,n,e){if(this._description){var o=this._description[t].existence[n][e];return Number(o)>0}return!0}}class os{constructor(t){this._node=t}getLabel(){return Wi.select(this._node.parentNode).select("text.chrLabel").text()}getSetLabel(){return Wi.select(this._node.parentNode).select("text.chrSetLabel").text()}}const rs=class{constructor(t,n){if(this._config=t,this._ideo=n,this._ploidy=this._ideo._ploidy,this._translate=void 0,"chrSetMargin"in t)this.chrSetMargin=t.chrSetMargin;else{var e=this._config.chrMargin;this.chrSetMargin=this._config.ploidy>1?e:0}this._tickSize=8,this._isRotated=!1}_getLeftMargin(){return this.margin.left}_getYScale(){return 20/this._config.chrWidth}getChromosomeLabels(t){var n=new os(t),e=[];return this._ideo.config.ploidy>1&&e.push(n.getSetLabel()),e.push(n.getLabel()),e.filter((function(t){return t.length>0}))}getChromosomeBandLabelTranslate(t){var n,e,o,r=this._ideo,i=this._tickSize,a=r.config.orientation;return"vertical"===a?o="rotate(-90)translate("+(n=i)+","+(e=r.round(2+t.px.start+t.px.width/2))+")":"horizontal"===a&&(o="translate("+(n=r.round(-i+t.px.start+t.px.width/2))+","+(e=-10)+")"),{x:n,y:e,translate:o}}didRotate(t,n){var e,o,r,i,a,s,c,l,u;o=(e=this._ideo).config.taxid,r=n.id.split("-")[0].replace("chr",""),i=(a=e.chromosomes[o][r]).bands,l=(c=Wi.select(n.parentNode)).attr("transform"),u=/scale\(.*\)/.exec(l),l=l.replace(u,""),c.attr("transform",l),s=a.width,(a=e.getChromosomeModel(i,r,o,t)).oldWidth=s,e.chromosomes[o][r]=a,e.drawChromosome(a),e.handleRotateOnClick(),e.rawAnnots&&(e.displayedTrackIndexes?e.updateDisplayedTracks(e.displayedTrackIndexes):(e.annots=e.processAnnotData(e.rawAnnots),e.drawProcessedAnnots(e.annots),e.config.filterable&&e.initCrossFilter())),!0===e.config.showBandLabels&&(e.drawBandLabels(e.chromosomes),e.hideUnshownBandLabels()),e.onDidRotateCallback&&e.onDidRotateCallback(a)}rotate(t,n,e){var o,r,i,a;o=this._ideo,a=o.selector+" .chrSetLabel, "+o.selector+" .chrLabel",i=document.querySelector(o.selector).getBoundingClientRect(),r=Wi.selectAll(o.selector+" g.chromosome").filter((function(){return this!==e})),this._isRotated?(this._isRotated=!1,o.config.chrHeight=o.config.chrHeightOriginal,o.config.chrWidth=o.config.chrWidthOriginal,o.config.annotationHeight=o.config.annotationHeightOriginal,this.rotateBack(t,n,e,(function(){r.style("display",null),Wi.selectAll(a).style("display",null),o._layout.didRotate(n,e)}))):(this._isRotated=!0,r.style("display","none"),Wi.selectAll(a).style("display","none"),this.rotateForward(t,n,e,(function(){var t,r,a;o.config.chrHeightOriginal=o.config.chrHeight,o.config.chrWidthOriginal=o.config.chrWidth,o.config.annotationHeightOriginal=o.config.annotationHeight,"VerticalLayout"===o._layout._class?(r=i.width-20,a=window.innerWidth-20):(r=i.height-10,a=window.innerHeight-10),t=a<r?a:r,t-=2*o.config.chrMargin,o.config.chrHeight=t,o.config.chrWidth*=2.3,o.config.annotationHeight*=1.7,o._layout.didRotate(n,e)})))}getChromosomeLabelClass(){return 1===this._config.ploidy?"chrLabel":"chrSetLabel"}_getAdditionalOffset(){var t=this._config,n=t.annotationsNumTracks||t.numAnnotTracks||1;return(t.annotationHeight||0)*n}_getChromosomeSetSize(t){return this._ploidy.getSetSize(t)*this._config.chrWidth*2+this.chrSetMargin}getChromosomeSetLabelAnchor(){return"middle"}getChromosomeLabelYPosition(){return-5.5}getChromosomeSetLabelYPosition(t){return 1===this._config.ploidy?this.getChromosomeLabelYPosition(t):-2*this._config.chrWidth}},is=class extends rs{constructor(t,n){super(t,n),this._class="VerticalLayout",this.margin={top:30,left:15}}rotateForward(t,n,e,o){var r="translate(20, 25) "+this.getChromosomeScale(e);Wi.select(e.parentNode).transition().attr("transform",r).on("end",o);var i=this.getChromosomeLabels(e),a=1.3*(20+this._config.chrWidth);Wi.select(this._ideo.getSvg()).append("g").attr("class","tmp").selectAll("text").data(i).enter().append("text").attr("class",(function(t,n){return 0===n&&2===i.length?"chrSetLabel":null})).attr("x",0).attr("y",a).style("opacity",0).text(String).transition().style("opacity",1),this._ideo.config.orientation="horizontal"}rotateBack(t,n,e,o){var r=this.getChromosomeScaleBack(e),i=this.getChromosomeSetTranslate(t);Wi.select(e.parentNode).transition().attr("transform",i+" "+r).on("end",o),Wi.selectAll(this._ideo.selector+" g.tmp").style("opacity",0).remove(),this._ideo.config.orientation="vertical"}getHeight(){return this._config.chrHeight+1.5*this.margin.top}getWidth(){return"97%"}getChromosomeBandTickY1(){return 2}getChromosomeBandTickY2(){return 10}getChromosomeSetLabelTranslate(){return"rotate(-90)"}getChromosomeBandLabelAnchor(){return null}getChromosomeScale(t){var n,e;return n=Wi.select(this._ideo.selector).node().getBoundingClientRect(),e=t.getBoundingClientRect(),"scale("+n.width/e.height*.97+", "+this._getYScale()+")"}getChromosomeScaleBack(t){var n,e,o;return e=(o=this._ideo.config).taxid,n=t.id.split("-")[0].replace("chr",""),"scale("+this._ideo.chromosomes[e][n].oldWidth/(3*o.chrHeight)*.97+", "+1/this._getYScale()+")"}getChromosomeSetTranslate(t){return"rotate(90) translate("+this.margin.top+", -"+this.getChromosomeSetYTranslate(t)+")"}getChromosomeSetYTranslate(t){var n,e=this._getAdditionalOffset(),o=this._config,r=o.chrMargin,i=o.chrWidth;if(!o.ploidyDesc)return"histogram"===o.annotationsLayout?r+t*(r+i+3)+2*o.barWidth:(n=i+t*(r+i)+2*e+("legendPad"in o?o.legendPad:0),e>0?n:n+4+2*t);if(!this._translate){var a;this._translate=[this._ploidy.getSetSize(0)*i*2];for(var s=1;s<this._config.ploidyDesc.length;s++)a=this._translate[s-1],this._translate[s]=a+this._getChromosomeSetSize(s-1)}return this._translate[t]}getChromosomeSetLabelXPosition(){return this._config.chrWidth*this._config.ploidy/-2}getChromosomeLabelXPosition(){return this._config.chrWidth/-2}},as=class extends rs{constructor(t,n){super(t,n),this._class="HorizontalLayout",this.margin={left:20,top:30}}_getLeftMargin(){var t=rs.prototype._getLeftMargin.call(this);return this._config.ploidy>1&&(t*=1.8),t}rotateForward(t,n,e,o){var r;Wi.select(e.parentNode).transition().attr("transform","rotate(90) translate(30, -37.5) ").on("end",o),r=this.getChromosomeLabels(e),Wi.select(this._ideo.getSvg()).append("g").attr("class","tmp").selectAll("text").data(r).enter().append("text").attr("class",(function(t,n){return 0===n&&2===r.length?"chrSetLabel":null})).attr("x",26).attr("y",(function(t,n){return 12*(n+1+r.length%2)})).style("text-anchor","middle").style("opacity",0).text(String).transition().style("opacity",1),this._ideo.config.orientation="vertical"}rotateBack(t,n,e,o){var r=this.getChromosomeSetTranslate(t);Wi.select(e.parentNode).transition().attr("transform",r).on("end",o),Wi.selectAll(this._ideo.selector+" g.tmp").style("opacity",0).remove(),this._ideo.config.orientation="horizontal"}getHeight(t){void 0===t&&(t=this._config.taxids[0]);var n=this._config.chromosomes[t].length,e=this.getChromosomeSetYTranslate(n-1);return(e+=this._getChromosomeSetSize(n-1))+2*this._getAdditionalOffset()}getWidth(){return this._config.chrHeight+1.5*this.margin.top}getChromosomeSetLabelAnchor(){return"end"}getChromosomeBandLabelAnchor(){return null}getChromosomeBandTickY1(){return 2}getChromosomeBandTickY2(){return 10}getChromosomeSetLabelTranslate(){return null}getChromosomeSetTranslate(t){return"translate("+this._getLeftMargin()+", "+this.getChromosomeSetYTranslate(t)+")"}getChromosomeSetYTranslate(t){if(!this._config.ploidyDesc)return this._config.chrMargin*(t+1);if(!this._translate){this._translate=[1];for(var n=1;n<this._config.ploidyDesc.length;n++)this._translate[n]=this._translate[n-1]+this._getChromosomeSetSize(n-1)}return this._translate[t]}getChromosomeSetLabelXPosition(t){return 1===this._config.ploidy?this.getChromosomeLabelXPosition(t):-20}getChromosomeSetLabelYPosition(t){var n=this._ploidy.getSetSize(t),e=this._config,o=e.chrMargin,r=e.chrWidth;return 1===e.ploidy?r/2+3:n*o/2}getChromosomeLabelXPosition(){return-8}getChromosomeLabelYPosition(){return this._config.chrWidth}},ss=class extends rs{constructor(t,n){super(t,n),this._class="PairedLayout",this.margin={left:30}}getHeight(){return this._config.chrHeight+1.5*this.margin.left}getWidth(){return"97%"}getChromosomeBandTickY1(t){return t%2?this._config.chrWidth:2*this._config.chrWidth}getChromosomeBandTickY2(t){var n=this._config.chrWidth;return t%2?n-this._tickSize:2*n+this._tickSize}getChromosomeBandLabelAnchor(t){return t%2?null:"end"}getChromosomeBandLabelTranslate(t,n){var e=n%2?10:-this._config.chrWidth-10,o=this._ideo.round(t.px.start+t.px.width/2)+3;return{x:o,y:o,translate:"rotate(-90) translate("+e+", "+o+")"}}getChromosomeLabelXPosition(){return-this._tickSize}getChromosomeSetLabelXPosition(){return this._config.chrWidth/-2}getChromosomeSetLabelTranslate(){return"rotate(-90)"}getChromosomeSetTranslate(t){var n=this.getChromosomeSetYTranslate(t);return"rotate(90) translate("+this.margin.left+", -"+n+")"}getChromosomeSetYTranslate(t){return 200*(t+1)}},cs=class extends rs{constructor(t,n){super(t,n),this._class="SmallLayout",this.margin={left:36.5,top:10};var e=this._ideo.getTaxid(this._ideo.config.organism);this.chrs=t.chromosomes[e];var o=this.chrs.length;this.chrsPerRow=Math.ceil(o/t.rows)}getHeight(){var t=1.25*this._config.chrHeight;return this._config.rows*(t+this.margin.top)}getWidth(){return"97%"}getChromosomeBandLabelTranslate(){}getChromosomeSetLabelTranslate(){return"rotate(-90)"}getChromosomeSetTranslate(t){var n,e;return t>this.chrsPerRow-1?(n=this.margin.left+1.3*this._config.chrHeight,e=this.getChromosomeSetYTranslate(t-this.chrsPerRow)):(n=this.margin.left,e=this.getChromosomeSetYTranslate(t)),"rotate(90) translate("+n+", -"+e+")"}getChromosomeSetYTranslate(t){var n=.3*this._getAdditionalOffset();return this.margin.left*t+this._config.chrWidth+2*n+n*t}getChromosomeSetLabelXPosition(t){return(this._ploidy.getSetSize(t)*this._config.chrWidth+20)/-2+(this._config.ploidy>1?0:this._config.chrWidth)}getChromosomeLabelXPosition(){return this._config.chrWidth/-2}};function ls(t){var n=this;n.config.annotationsPath&&n.fetchAnnots(n.config.annotationsPath),function(t){if("ploidyDesc"in t.config&&"string"==typeof t.config.ploidyDesc){for(var n=[],e=0;e<t.numChromosomes;e++)n.push(t.config.ploidyDesc);t.config.ploidyDesc=n}t._ploidy=new es(t.config)}(n),n._layout=function(t){var n=t.config;return"perspective"in n&&"comparative"===n.perspective?new ss(n,t):"rows"in n&&n.rows>1?new cs(n,t):"vertical"===n.orientation?new is(n,t):"horizontal"===n.orientation?new as(n,t):new is(n,t)}(n),function(t){Wi.selectAll(t.config.container+" #_ideogramOuterWrap").remove(),Wi.select(t.config.container).append("div").attr("id","_ideogramOuterWrap").append("div").attr("id","_ideogramTrackLabelContainer").style("position","absolute"),Wi.select(t.config.container+" #_ideogramOuterWrap").append("div").attr("id","_ideogramMiddleWrap").style("position","relative").style("overflow-x","auto").style("transform","translateZ(0)").append("div").attr("id","_ideogramInnerWrap").append("svg").attr("id","_ideogram").attr("class",function(t){var n="";return t.config.showChromosomeLabels&&("horizontal"===t.config.orientation?n+="labeledLeft ":n+="labeled "),!1===t.config.rotatable&&(n+="no-rotate "),t.config.annotationsLayout&&"overlay"===t.config.annotationsLayout&&(n+="faint"),n}(t)).attr("width",t._layout.getWidth()).attr("height",t._layout.getHeight()).html(t.getBandColorGradients())}(n),n.isOnlyIdeogram=1===document.querySelectorAll("#_ideogram").length,function(t){Wi.select(t.config.container+" #_ideogramOuterWrap").append("div").attr("class","_ideogramTooltip").attr("id","_ideogramTooltip").style("opacity",0).style("position","fixed").style("text-align","center").style("padding","4px").style("font","12px sans-serif").style("background","white").style("border","1px solid black").style("border-radius","5px").style("z-index","1000")}(n),n.finishInit(t)}var us="";function hs(t,n,e){return e.config.dataDir+t[n]}function fs(t,n,e){var o=e.config.ploidy;return"sex"in e.config&&(2===o&&e.sexChromosomes.index+1===n||"female"===e.config.sex&&"Y"===t.name)}function ds(t,n,e,o){var r,i,a,s,c;for(r=0;r<n.length;r++)a=n[r],void 0!==t&&(i=t[r]),c=r+o.config.taxids.indexOf(e),s=o.getChromosomeModel(i,a,e,c),"string"!=typeof a&&(a=a.name.split(" ").slice(-1)[0].replace("chr","")),o.chromosomes[e][a]=s,o.chromosomesArray.push(s),fs(s,r,o)||o.drawChromosome(s)}function ms(t,n){"undefined"!=typeof chrBands&&t.length>=chrBands.length/2&&(n.coordinateSystem="bp")}function ps(){var t,n,e,o,r=this,i=r.config.taxids;for(n=0;n<i.length;n++)t=i[n],e=r.config.chromosomes[t],o=r.bandsArray[t],r.config.showNonNuclearChromosomes||(e=e.filter((t=>"MT"!==t)),void 0!==o&&(o=o.filter((t=>"MT"!==t[0].chr)))),ms(e,r),r.chromosomes[t]={},r.setSexChromosomes(e),ds(o,e,t,r),r.config.showBandLabels&&r.drawBandLabels(r.chromosomes),r.handleRotateOnClick(),r._gotChrModels=!0}function gs(){var t=this;"rotatable"in t.config&&!1===t.config.rotatable?Wi.selectAll(t.selector).style("cursor","default"):Wi.selectAll(t.selector+" .chromosome-set").on("click",(function(){const n=this.children[1];t.rotateAndToggleDisplay(n)}))}function ys(){call(this.onLoadCallback)}function vs(t,n,e){var o=e.organisms[t],r=[ra(o.scientificName)],i=o.assemblies,a=e.config.resolution;return n!==i.default&&r.push(n),"9606"===t&&(n in i==="false"&&Object.values(i).includes(config.assembly)||""!==a&&850!==a)&&r.push(a),r=r.join("-"),["9606","10090","10116"].includes(t)&&!e.config.showFullyBanded&&(r+="-no-bands"),r+".json"}function bs(t,n,e){var o,r,i,a=e.config;o=e.organisms[t],a.assembly||(e.config.assembly="default"),r=o.assemblies,i=vs(t,e.assemblyIsAccession()?a.assembly:r[a.assembly],e);var s="-1"===t;return(t in e.organismsWithBands||s)&&(n[t]=i),n}function ws(t,n,e,o){return function(t,n,e){var o=hs(t,n,e);return(!(void 0!==window.chrBands&&""===us)||us!==o)&&function(t){return"assembly"in t.config&&!1===/(GCA_)/.test(t.config.assembly)}(e)&&n in t}(n,t,o)?function(t,n,e,o){var r=hs(t,n,o);return o.numBandDataResponses||(o.numBandDataResponses=0),Xi(r).then((function(n){return n.json().then((function(e){us=r,delete window.chrBands,window.chrBands=e.chrBands,function(t,n,e,o){var r,i,a;for(r in n)a=n[r],t.includes(a)&&""!==a&&(i=r);o.bandData[i]=e}(n.url,t,chrBands,o)}))}))}(n,t,0,o).then((function(){return o.processBandData(t)})):new Promise((function(n){o.processBandData(t),n([t,void 0])}))}var _s={},xs={},As={};function Cs(t){var n=(t=t||this).config.container;As[n]?(xs[n]=!0,_s[n]=t):(As[n]=!0,function(t){return new Promise((function(n){var e=t.config.organism;"number"==typeof e?t.getOrganismFromEutils(e,(function(){t.getTaxids(n)})):t.getTaxids(n)}))}(t).then((function(e){var o=e[0];t.config.taxid=o,t.config.taxids=e,t.organismScientificName=t.getScientificName(t.config.taxid),function(t,n,e){var o,r,i,a=[];for(i in o={},zi)o[i]="";for(r=0;r<t.length;r++)o=bs(i=String(t[r]),o,e),a.push(ws(i,o,0,e));Promise.all(a).then((function(t){var o,i,a;for(r=0;r<t.length;r++)i=(o=t[r])[0],a=o[1],"bandsArray"in e==0&&(e.bandsArray={}),e.bandsArray[i]=a;e.writeContainer(n)}))}(e,(new Date).getTime(),t),As[n]=!1,xs[n]&&(xs[n]=!1,Cs(_s[n]))})))}class Ss{constructor(t,n){this.rawAnnots=this.parseBed(t,n)}static componentToHex(t){var n=parseInt(t,10).toString(16);return 1===n.length?"0"+n:n}static rgbToHex(t,n,e){return"#"+Ss.componentToHex(t)+Ss.componentToHex(n)+Ss.componentToHex(e)}parseGenomicCoordinates(t,n){var e,o,r,i;return e=t[0],o=parseInt(t[1],10),i=(r=parseInt(t[2],10))-o,n&&(e=e.slice(3)),[e,o,r,i]}parseAnnotFromTsvLine(t,n,e){var o,r,i,a,s,c,l,u=t.split(/\s/g);return[i,a,stop,length]=this.parseGenomicCoordinates(u,e),-1===(r=n.indexOf(i))?[null,null]:(o=["",a,length,0],u.length>=4&&(l=u[3],o[0]=l),u.length>=8&&(s=u[8].split(","),c=Ss.rgbToHex(s[0],s[1],s[2]),o.push(c)),[r,o])}parseRawAnnots(t,n,e,o){var r,i,a,s,c,l;for(l=!0,!1===isNaN(parseInt(e[n],10))&&(l=!1),r=n;r<e.length;r++)i=e[r],[a,s]=this.parseAnnotFromTsvLine(i,o,l),null!==a&&t[a].annots.push(s);return c=["name","start","length","trackIndex"],e[n].length>=8&&c.push("color"),{keys:c,annots:t}}parseBed(t,n){var e,o,r,i,a=[],s=t.split(/\r\n|\n/);for(o=Object.keys(n.chromosomes[n.config.taxid]),e=0;e<o.length;e++)r=o[e],a.push({chr:r,annots:[]});return i=0,("chr"===s[0].slice(0,3)||isNaN(parseInt(s[0],10)))&&(i=1),this.parseRawAnnots(a,i,s,o)}}class ks{constructor(t,n){this.rawAnnots=this.parseTsv(t,n)}parseGenomicCoordinates(t){return[t[1],parseInt(t[2],10),parseInt(t[3],10)]}parseTsv(t,n){const e=t.split(/\r\n|\n/),o=Object.keys(n.chromosomes[n.config.taxid]),r=[];for(let t=0;t<o.length;t++){const n=o[t];r.push({chr:n,annots:[]})}let i;const a={},s=[];for(let t=0;t<e.length;t++){const n=e[t];if(""===n)continue;if("#"===n[0]){if("#"===n[1]){const t=n.split(" keys: ");if(t.length>1){const n=t[0].slice(3),e=t[1].split(";");a[oa(n)]=e}}else i=n.slice(1).trim().split(/\t/).map((t=>oa(t))),i.slice(4).forEach(((t,n)=>s.push(oa(t))));continue}const c=n.trim().split(/\t/),l=c[0],[u,h,f]=this.parseGenomicCoordinates(c),d=o.indexOf(u);if(-1===d)continue;const m=c.slice(4);for(let t=0;t<4;t++){const n=s[t];if(n in a){const e=a[n],o=c[4+t].split(";"),r=[];if(""!==o[0])for(let t=0;t<o.length;t++){const n={},i=o[t].split("!");for(let t=0;t<i.length;t++){const o=e[t],r=i[t];n[oa(o)]=r}r.push(n)}m[t]=r}}const p=[l,u,h,f].concat(m);r[d].annots.push(p)}return{keys:i,annots:r,innerKeysByField:a}}}var Ts=["name","start","length","trackIndex","trackIndexOriginal","color"],Ls={3:["00B","DDD","F00"],5:["00D","66D","DDD","F88","F00"],17:["00D","00D","00D","00D","00D","44D","44D","DDD","DDD","DDD","DDD","F88","F66","F22","F22","F00","F00","F00"]};function Ms(t){var n,e,o;if(t.rawAnnots.metadata&&t.rawAnnots.metadata.trackLabels)n=t.rawAnnots.metadata.trackLabels;else if(t.config.heatmaps)for(n=[],e=t.config.heatmaps,o=0;o<e.length;o++)n.push(e[o].key);else n=t.rawAnnots.keys.slice(0).filter((t=>!Ts.includes(t)));return t.displayedTrackIndexes&&(n=n.filter((function(n,e){return t.displayedTrackIndexes.includes(e+1)}))),n}function Es(t){var n,e,o=t.rawAnnots;if(!o.metadata||o.metadata.heatmapThresholds||t.config.heatmapThresholds)return n=t.config.heatmapThresholds?t.config.heatmapThresholds:t.rawAnnots.metadata.heatmapThresholds,e=Ls[n.length+1],n=n.map(((t,n)=>[t,"#"+e[n]])),n.push(["+","#"+e.slice(-1)[0]]),n}function Ns(t,n,e,o,r){return t===n&&"+"===r&&e>o||e===r||0!==t&&t!==n&&e<=r&&e>o||0===t&&e<=r}function Ps(t,n){var e,o,r,i,a,s,c,l;for(e=0;e<t.length;e++)o=t.length-1,i=(r=t[e])[0],a=parseFloat(i),!1===isNaN(a)&&(i=a),0!==e&&(c=parseFloat(t[e-1][0])),s=r[1],Ns(e,o,n,c,i)&&(l=s);return l}function Ds(t,n,e){var o,r,i,a,s,c=t.width,l=[],u=e.config.annotLabelHeight,h=e.config.numAnnotTracks;for(o=0;o<h;o++)i=e.config.annotationHeight+u+4,s=t.id+"-canvas-"+o,r=n,t.chrIndex>0&&(r+=e.config.chrMargin*t.chrIndex-1),a=Wi.select(e.config.container+" #_ideogramInnerWrap").append("canvas").attr("id",s).attr("width",c+1).attr("height",i).style("position","absolute").style("left",r+"px").style("top",i*o+1+"px").nodes()[0].getContext("2d"),l.push([a,t]);return l}function Bs(t,n,e){var o,r,i,a,s=e.config.annotLabelHeight,c=e.config.annotationHeight,l=e.config.demarcateCollinearChromosomes,u=c+s+4;for(o=0;o<t.length;o++)if(i=n[(r=t[o]).trackIndex][0],a=n[r.trackIndex][1],i.fillStyle=r.color,l){if(r.startPx<1||r.startPx>a.width-1)continue;i.fillRect(r.startPx,1,.5,u)}else i.fillRect(r.startPx,s+1,.5,c);if(l)for(o=0;o<n.length;o++)i=n[o][0],a=n[o][1],i.fillStyle="#555",0===a.chrIndex&&i.fillRect(0,0,1,u),i.fillRect(a.width-1,0,1.1,u),i.fillRect(0,0,a.width+1,1),e.config.chrMargin&&i.fillRect(0,0,1.1,u)}function Is(t,n,e){var o,r,i,a=e.config.annotationHeight,s=e._layout.margin.top;for(i=t.values,o=0;o<i.length;o++)n.fillStyle=i[o],r=(o-1)*a,n.fillRect(r,t.startPx+s,a,2)}function Fs(t,n,e,o,r,i,a){var s,c,l,u,h,f,d,m=a.config.heatmapThresholds;for(s=0;s<e.annots.length;s++){for(u=e.annots[s],(l={}).values=[],c=0;c<3;c++)l[i[c]]=u[c];for(c=3;c<i.length;c++)d=Ps(m,u[c]),l.values.push(d);h=l.start+l.length,l.chr=e.chr,l.chrIndex=r,l.startPx=a.convertBpToPx(o,l.start),f=a.convertBpToPx(o,h),l.px=Math.round((l.startPx+f)/2),t.push(l)}return t.shift(),[t,n]}function $s(t){!1!==t.config.showTrackLabel&&(t.hideTrackLabelTimeout=window.setTimeout((function(){Wi.select(t.config.container+" #_ideogramTrackLabel").transition().duration(500).style("opacity",0)}),250))}function Rs(t,n,e,o){var r,i,a,s,c,l=[],u=o.config.numAnnotTracks;for(r=0;r<u;r++)a=o.config.annotationHeight,c=t.id+"-canvas-"+r,i=n-a*(u-r)-7,s=Wi.select(o.config.container+" #_ideogramInnerWrap").append("canvas").attr("id",c).attr("width",a).attr("height",e).style("position","absolute").style("left",i+"px").nodes()[0].getContext("2d"),l.push(s);return l}function Gs(t,n,e,o){var r,i,a,s;for(r=0;r<t.length;r++)(a=n[(i=t[r]).trackIndex]).fillStyle=i.color,s=i.trackIndex-1,a.fillRect(s,i.startPx+o,e,.5)}function Os(t){var n,e,o,r,i=this,a=i.config,s=i._layout.margin.top,c=a.chrHeight+s;if("collinear"===a.geometry)return function(t,n){var e,o,r,i,a=0,s=n.config.showChromosomesLabels?2:-.1;for(Wi.select(n.selector).classed("labeledLeft",!1),Wi.selectAll(n.config.container+" canvas").remove(),r=0;r<t.length;r++)e=t[r].annots,i=n.chromosomesArray[r],0===r?o=12:(o=a+n.chromosomesArray[r-1].width+14,a+=n.chromosomesArray[r-1].width+s),Bs(e,Ds(i,o,n),n);(function(t){!function(t,n){var e,o,r,i,a=n.config.annotLabelHeight;for(i=n.config.demarcateCollinearChromosomes?2:0,(r=Wi.select(n.config.container+" 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i=t.id+"-canvas",r=2*o.config.chrWidth+o.config.annotationHeight-.5,Wi.select(o.config.container+" #_ideogramInnerWrap").append("canvas").attr("id",i).attr("width",e).attr("height",n).style("position","absolute").style("left",r+"px").style("top","0px").nodes()[0].getContext("2d")}(n.chromosomesArray[0],a,s,n),o=0;o<t.length;o++)Is(t[o],e,n);n.onDrawAnnotsCallback&&n.onDrawAnnotsCallback()}(t,i);for(Wi.selectAll(i.config.container+" canvas").remove(),function(t){Wi.select(t.config.container+" #_ideogramTrackLabelContainer").append("div").attr("id","_ideogramTrackLabel").style("opacity",0).style("position","absolute").style("text-align","center").style("padding","1px").style("font","11px sans-serif").style("background","white").style("line-height","10px").style("z-index","9000")}(i),o=0;o<t.length;o++)n=t[o].annots,r=i.chromosomesArray[o],e=i.config.chrWidth,Gs(n,Rs(r,i._layout.getChromosomeSetYTranslate(o),c,i),e,s);Wi.selectAll(i.config.container+" canvas").on("mouseover",(function(){!function(t,n){var e,o,r;clearTimeout(n.hideTrackLabelTimeout),e=(e=Ms(n)).join("<br>"),Wi.select(n.config.container+" #_ideogramTrackLabel").interrupt().style("top","").style("left","").style("transform",null).style("transform","rotate(-90deg)").html(e),[o,r]=function(t,n,e){var o,r,i,a,s;return o=n.id.split("-").slice(0,-1).join("-")+"-0",r=Wi.select(e.config.container+" #"+o).nodes()[0].getBoundingClientRect(),i=Wi.select(e.config.container+" #_ideogramTrackLabel").nodes()[0].getBoundingClientRect(),a=Wi.select(e.config.container).nodes()[0].getBoundingClientRect(),s=Math.round(r.left+i.width)-r.width-1,[s-=a.left-7,-(t.split("<br>").length-2)*r.width+2]}(e,t,n),function(t,n,e){Wi.select(e.config.container+" #_ideogramTrackLabel").style("opacity",1).style("left",n+"px").style("top",t+"px").style("width","max-content").style("transform-origin","bottom 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o,r,i,a,s,c,l,u;for(o=0;o<t.length;o++)r=t[o],[i,a]=yc(r,e),pc(s=mc(n,i.chr.id+"_"+i.start+"_"+i.stop+"___"+a.chr.id+"_"+a.start+"_"+a.stop,e),l=(c=e.config.chrWidth)+51,u=c+245,i,a,r),vc(s,l,u,i,a)})(t,Wi.select(n.selector).insert("g",":first-child").attr("class","synteny"),n),function(t,n){var e=(new Date).getTime();n.config.debug&&console.log("Time in drawSyntenicRegions: "+(e-t)+" ms")}(e,n)}(t,e):function(t,n){var e=(new Date).getTime();(function(t,n,e){var o,r,i,a,s,c,l,u;for(o=0;o<t.length;o++)r=t[o],[i,a]=yc(r,e),gc(s=mc(n,i.chr.id+"_"+i.start+"_"+i.stop+"___"+a.chr.id+"_"+a.start+"_"+a.stop,e),l=(c=e.config.chrWidth)+31,u=c+191,i,a,r),bc(s,l,u,i,a)})(t,Wi.select(n.selector).insert("g",":first-child").attr("class","synteny"),n),function(t,n){var e=(new Date).getTime();n.config.debug&&console.log("Time in drawSyntenicRegions: "+(e-t)+" ms")}(e,n)}(t,e);(function(t,n,e,o){var r,i,a,s,c,l,u,h,f;for(r=0;r<t.length;r++)i=t[r],[a,s]=yc(i,o,e),l=mc(n,c=a.chr.id+"_"+a.start+"_"+a.stop+"___"+s.chr.id+"_"+s.start+"_"+s.stop,o),u=o.config.chrWidth,pc(l,h=o._layout.getChromosomeSetYTranslate(0),f=o._layout.getChromosomeSetYTranslate(1)-u,a,s,i),wc(l,h,f,a,s,i),_c(l,h,f,a,s,c)})(t,Wi.select(e.selector).insert("g",":first-child").attr("class","synteny"),e._layout.margin.left,e),function(t,n){var e=(new Date).getTime();n.config.debug&&console.log("Time in drawSyntenicRegions: "+(e-t)+" ms")}(n,e)}function Ac(){var t=this;t.config.numAnnotTracks=t.config.annotationsNumTracks,Wi.selectAll(t.selector+" .annot").remove(),t.drawAnnots(t.processAnnotData(t.rawAnnots))}function Cc(t){var n,e,o,r=this,i=r.rawAnnots.annots;return r.config.numAnnotTracks=t.length,n=function(t,n){var e,o,r,i,a,s,c;for(o=[],i=0;i<t.length;i++){for(r=t[i],a=[],s=0;s<r.annots.length;s++)c=(e=r.annots[s].slice())[3]+1,n.includes(c)&&(e[3]=n.indexOf(c),a.push(e));o.push({chr:r.chr,annots:a})}return o}(i,t),o={keys:r.rawAnnots.keys,annots:n},"collinear"===r.config.geometry&&da(r),e=r.processAnnotData(o),Wi.selectAll(r.selector+" .annot").remove(),r.displayedTrackIndexes=t,r.drawAnnots(e),e}function Sc(t){var n,e,o=this;return(n=t.keys).length<4||"trackIndex"!==n[3]||"trackIndexOriginal"===n[4]||(e=function(t,n){var e,o,r,i,a,s,c,l=[];for(c=1,e=0;e<t.length;e++){for(r=t[e],a=[],o=0;o<r.annots.length;o++)(s=(i=r.annots[o].slice())[3])+1>c&&(c=s+1),i.splice(4,0,s),a.push(i);l.push({chr:r.chr,annots:a})}return n.numAvailTracks=c,l}(t.annots,o),n.splice(4,0,"trackIndexOriginal"),t={keys:n,annots:e},o.rawAnnots.metadata&&(t.metadata=o.rawAnnots.metadata)),t}var kc=[["F00"],["F00","88F"],["F00","CCC","88F"],["F00","FA0","0AF","88F"],["F00","FA0","CCC","0AF","88F"],["F00","FA0","875","578","0AF","88F"],["F00","FA0","875","CCC","578","0AF","88F"],["F00","FA0","7A0","875","0A7","578","0AF","88F"],["F00","FA0","7A0","875","CCC","0A7","578","0AF","88F"],["F00","FA0","7A0","875","552","255","0A7","578","0AF","88F"]];function Tc(t,n,e,o,r,i,a){return a.config.annotationTracks?r=function(t,n,e,o,r){var i;return n.trackIndex=e[3],(i=r.config.annotationTracks[n.trackIndex]).color&&(n.color=i.color),i.shape&&(n.shape=i.shape),t[o].annots.push(n),t}(r,t,e,i,a):"trackIndex"===n[3]&&1!==a.numAvailTracks?[r,o]=function(t,n,e,o,r,i){var a=kc[i.numAvailTracks-1];return t.trackIndex=n[3],t.trackIndexOriginal=n[4],t.color="#"+a[t.trackIndexOriginal],t.trackIndex>i.config.numTracks-1?(t.trackIndex in e?e[t.trackIndex].push(t):e[t.trackIndex]=[t],[o,e]):(o[r].annots.push(t),[o,e])}(t,e,o,r,i,a):r=function(t,n,e,o){return n.trackIndex=0,n.color||(n.color=o.config.annotationsColor),n.shape||(n.shape="triangle"),t[e].annots.push(n),t}(r,t,i,a),[r,o]}function Lc(t,n){return"_c"+t+"_a"+n}function Mc(t,n,e,o,r,i,a){var s,c,l,u;const h=!a.config.annotationsLayout||"tracks"===a.config.annotationsLayout;for(s=0;s<e.annots.length;s++){for(u=e.annots[s],l={},c=0;c<i.length;c++)l[i[c]]=u[c];l.stop=l.start+l.length,l.chr=e.chr,l.chrIndex=r,l.startPx=a.convertBpToPx(o,l.start),l.stopPx=a.convertBpToPx(o,l.stop),l.px=Math.round((l.startPx+l.stopPx)/2),h&&(l.domId=Lc(r,s)),[t,n]=Tc(l,i,u,n,t,r,a)}if(h)for(a.annotSortFunction?(t[r].annots=Gc(t[r].annots,a),t[r].annots.sort(((t,n)=>-a.annotSortFunction(t,n)))):t[r].annots.sort(((t,n)=>t[1]-n[1])),s=0;s<t[r].annots.length;s++)t[r].annots[s].domId=Lc(r,s);return[t,n]}function Ec(t){console.warn('Chromosome "'+t.chr+'" undefined in ideogram; '+t.annots.length+" annotations not shown")}function Nc(t){var n,e,o,r=this;return n=t.keys,t=t.annots,[e,o]=function(t,n,e){var o,r,i,a,s=[],c={};for(o=-1,r=0;r<t.length;r++)i=t[r],void 0!==(a=e.chromosomes[e.config.taxid][i.chr])?(o++,s.push({chr:i.chr,annots:[]}),"heatmap-2d"!==e.config.annotationsLayout?[s,c]=Mc(s,c,i,a,o,n,e):[s,c]=Fs(s,c,i,a,o,n,e)):Ec(i);return[s,c]}(t,n,r),e=function(t,n){var e,o,r,i,a,s;for(e=t,t=[],s=n.chromosomesArray,o=0;o<s.length;o++)for(a=s[o].name,r=0;r<e.length;r++)(i=e[r]).chr===a&&t.push(i);return t}(e,r),function(t,n){var e,o=n.config.annotationsLayout,r=n.config.numAnnotTracks;!/heatmap/.test(o)&&r>10&&console.error("Ideogram only displays up to 10 tracks at a time.  You specified "+r+" tracks.  Perhaps consider a different way to visualize your data."),(e=Object.keys(t).length)&&console.warn("Ideogram configuration specified "+r+" tracks, but loaded annotations contain "+e+" extra tracks.")}(o,r),e}class Pc{constructor(t,n){this.matrix=t,this.ideo=n}setRawAnnots(){var t,n,e;return t=this,n=this.ideo,e=this.matrix,new Promise((function(o){t.rawAnnots=t.fetchCoordinates(n).then((function(r){t.coordinates=r,o(t.parseExpressionMatrix(e,n))}))}))}fetchCoordinates(t){var n={};if("human"===t.config.organism){var e=t.config.dataDir+"../../annotations/Homo_sapiens,_Ensembl_80.tsv";return new Promise((function(o){t.fetch(e,"text").then((function(t){var e,r,i,a,s,c,l;for(e=t.split(/\r\n|\n/).slice(1),r=0;r<e.length;r++)[i,a,s,,c]=e[r].split(/\s/g),i=parseInt(i),l=(a=parseInt(a))-i,n[s]=[c,i,l];o(n)}))}))}throw Error("Expression matrix parsing is only supported for human")}parseAnnotFromTsvLine(t,n){var e,o,r,i,a,s=t.split(/\s/g);return(i=s[0])in this.coordinates==0?[null,null]:(a=s.slice(1).map((t=>parseFloat(t))),[o,r,length]=this.coordinates[i],-1===(e=n.indexOf(o))?[null,null]:[e,[i,r,length].concat(a)])}parseExpressionMatrix(t,n){var e,o,r,i,a,s,c=[],l=t.split(/\r\n|\n/);for(o=Object.keys(n.chromosomes[n.config.taxid]),e=0;e<o.length;e++)c.push({chr:o[e],annots:[]});for(e=1;e<l.length;e++)i=l[e],[a,s]=this.parseAnnotFromTsvLine(i,o),null!==a&&c[a].annots.push(s);return r=l[0].split(/\s/g),{keys:["name","start","length"].concat(r),annots:c}}}function Dc(){const t=this,n={};t.annots.forEach((e=>{e.annots.forEach((e=>{const o=t.annotDescriptions.annots[e.name];n[e.name]=[e.name,o.ensemblId,e.chr,e.start,e.stop,e.length,o.type]}))}));const e=[["# Gene name","Ensembl ID","Chromosome","Start","Stop","Length","Type"]].concat(Object.values(n)),o=t.annotDescriptions.headers+"\n#\n"+e.map((t=>t.join("\t"))).join("\n"),r="data:text/plain;charset=utf-8,"+encodeURIComponent(o);var i=new MouseEvent("click",{view:window,bubbles:!1,cancelable:!0}),a=document.createElement("a");a.setAttribute("download","ideogram.tsv"),a.setAttribute("href",r),a.setAttribute("target","_blank"),a.setAttribute("id","_ideo-undisplayed-dl-annots-link"),a.setAttribute("style","display: none;"),document.body.appendChild(a),a.dispatchEvent(i)}function Bc(){var t=this,n=t.config;!function(t){var n,e=t.config;e.annotationHeight||("heatmap"===e.annotationsLayout?n=e.chrWidth-1:(n=Math.round(e.chrHeight/100))<3&&(n=3),t.config.annotationHeight=n)}(t),n.annotationsPath||n.localAnnotationsPath||t.annots||n.annotations?function(t,n){n.annotationTracks?t.config.numAnnotTracks=n.annotationTracks.length:n.annotationsNumTracks?t.config.numAnnotTracks=n.annotationsNumTracks:t.config.numAnnotTracks=1,t.config.annotTracksHeight=n.annotationHeight*n.numAnnotTracks,void 0===n.barWidth&&(t.config.barWidth=3)}(t,n):(t.config.annotTracksHeight=0,t.config.numAnnotTracks=0),void 0===n.annotationsColor&&(t.config.annotationsColor="#F00"),n.onClickAnnot&&(t.onClickAnnotCallback=n.onClickAnnot),function(t,n){!1!==n.showAnnotTooltip&&(t.config.showAnnotTooltip=!0),n.onWillShowAnnotTooltip&&(t.onWillShowAnnotTooltipCallback=n.onWillShowAnnotTooltip),n.onDidShowAnnotTooltip&&(t.onDidShowAnnotTooltipCallback=n.onDidShowAnnotTooltip)}(t,n),function(t,n){!1!==n.addAnnotLabel&&(t.config.addAnnotLabel=!0),n.onWillAddAnnotLabel&&(t.onWillAddAnnotLabelCallback=n.onWillAddAnnotLabel)}(t,n)}function Ic(){var t=this,n=t.config;t.rawAnnots.annots=t.rawAnnots.annots.sort(Ideogram.sortChromosomes),t.onLoadAnnotsCallback&&t.onLoadAnnotsCallback(),("heatmapThresholds"in n||"metadata"in t.rawAnnots&&"heatmapThresholds"in t.rawAnnots.metadata)&&("heatmap"===n.annotationsLayout?function(t){var n,e,o,r,i,a,s=t.config.heatmapThresholds;for(o=[],e=(i=t.rawAnnots).keys.slice(3),r=[],a=[],!i.metadata&&isNaN(s[0])||(s=Es(t)),n=0;n<e.length;n++)o.push({key:e[n],thresholds:s}),r.push({id:e[n]}),a.push(n+1);t.config.annotationsNumTracks=e.length,t.config.annotationsDisplayedTracks=a,t.config.heatmaps=o,t.config.annotationTracks=r}(t):"heatmap-2d"===n.annotationsLayout&&(t.config.heatmapThresholds=Es(t))),n.heatmaps&&t.deserializeAnnotsForHeatmap(t.rawAnnots),function(t){const n={},e=[],o=t.rawAnnots.annots.map((t=>t.chr));if(o.forEach((t=>{t in n&&e.push(t),n[t]=1})),e.length>0)throw Error(`Duplicate chromosomes detected.\nChromosome list: ${o}.  Duplicates: ${e}.\nTo fix this, edit your raw annotations JSON data to remove redundant chromosomes.`)}(t)}function Fc(){return this.annots.reduce(((t,n)=>[...t,...n.annots]),[])}function $c(t){var n,e=this,o=e.config;n="heatmap-2d"===o.annotationsLayout;var r=function(t){var n,e;return e=(n=t.split("?")[0].split("."))[n.length-1],!1===["bed","json","tsv"].includes(e)?(e=e.toUpperCase(),void alert("Ideogram.js only supports BED and Ideogram JSON and TSV at the moment.  Sorry, check back soon for "+e+" support!")):e}(t);"http"===t.slice(0,4)||n||"tsv"===r?(r=n?"":r,e.fetch(t,"text").then((function(t){e.rawAnnotsResponse=t,n?new Pc(t,e).setRawAnnots().then((function(t){e.rawAnnots=t,e.afterRawAnnots()})):(e.rawAnnots="tsv"===r?new ks(t,e).rawAnnots:"bed"===r?new Ss(t,e).rawAnnots:JSON.parse(t),e.afterRawAnnots())}))):e.fetch(t).then((function(t){e.rawAnnotsResponse=t,e.rawAnnots=t,e.afterRawAnnots()}))}function Rc(t){var n,e,o,r,i,a,s;for(n=[],e=[],o=this.chromosomesArray,r=0;r<o.length;r++)i=o[r].name,e.push(i),n.push({chr:i,annots:[]});for(r=0;r<t.length;r++)a=t[r],-1!==(s=e.indexOf(a.chr))&&(n[s]=a);return n}function Gc(t,n){if("geneCache"in n==0)return t;const e=n.geneCache.interestingNames;return t.map((t=>(e.includes(t.name)?t.rank=e.indexOf(t.name)+1:t.rank=1e10,t)))}function Oc(t,n="red"){const e=this,o=e.config.taxid,r=t.map((t=>{const r=e.chromosomes[o][t].id,i=`${e.selector} #${r}-chromosome-set`,a=document.querySelector(i),s=a.getBoundingClientRect();return`<rect class="ideo-highlight" id="ideo-highlight-${r}" style="\n      stroke-width: 1px;\n      stroke: ${n};\n      fill: ${n};\n      fill-opacity: 0.05;\n      position: absolute;\n      rx: 4;\n      ry: 4;\n      height: ${s.width+15}px;\n      width: ${s.height+15}px" transform="rotate(90) translate(10, ${a.transform.baseVal[1].matrix.f-7.5})"/>`})).join();document.querySelector(e.selector).insertAdjacentHTML("afterBegin",r)}function jc(t){const n=this;let e=`${n.selector} .ideo-highlight`;if(void 0!==t){const o=n.config.taxid;e=t.map((t=>{const e=n.chromosomes[o][t].id;return`${n.selector} #ideo-highlight-${e}`}))}document.querySelectorAll(e).forEach((t=>{t.remove()}))}function Hc(t,n){var e,o;return e=n.esearch+"&db=taxonomy&term="+t,Wi.json(e).then((function(n){if(0===n.esearchresult.idlist.length)throw'Organism "'+t+"\" is generally unknown; it was not found in the NCBI Taxonomy database.  If you did not intend to specify a novel or custom taxon, then try using the organism's scientific name, e.g. Homo sapiens or Arabidopsis thaliana.";return o=n.esearchresult.idlist[0],[t,o]}))}function qc(t,n){var e,o,r=this;t=r.config.organism,o=r.esummary+"&db=taxonomy&id="+t,Wi.json(o).then((function(o){return e=o.result[String(t)].commonname,r.config.organism=e,n(e)}))}function zc(t,n,e){var o,r,i,a,s,c=e.config;(function(t,n){var e,o,r;if(n.assemblyIsAccession())return new Promise((function(e){n.coordinateSystem="bp",n.getAssemblyAndChromosomesFromEutils(t,e)}));e=n.config.dataDir,o=ra(n.organisms[t].scientificName),r=[t],["9606","10090","10116"].includes(t)&&!n.config.showFullyBanded&&(o+="-no-bands");var i=e+o+".json",a=new Promise(((t,n)=>Xi(i).then((n=>n.json().then((function(n){t(n)})))).catch((t=>{n(t)}))));return a.then((function(e){var o,i,a,s,c=e.chrBands,l=[""],u=[],h={};n.bandData[e.taxid]=c;for(var f=0;f<c.length;f++)o=(a=c[f].split(" "))[0],s=a.slice(-1)[0],o in h||(u.push({name:o,type:"nuclear",length:s}),h[o]=1);return u=u.sort(Ideogram.sortChromosomes),i={bp:0,iscn:0},u.forEach((t=>{t.length>i.bp&&(i.bp=t.length)})),n.maxLength[t]=i,l.push(u),l.push(r),l}),(function(){return new Promise((function(e){n.coordinateSystem="bp",n.getAssemblyAndChromosomesFromEutils(t,e)}))}))})(t,e).then((function(l){o=l[0],r=l[1],"chromosomes"in c==0||null===c.chromosomes?(e.config.chromosomes={},e.config.chromosomes[t]=r):(c.multiorganism?t in c.chromosomes?i=c.chromosomes[t]:(a=ra(e.getScientificName(t)),e.config.chromosomes[t]=c.chromosomes[a].slice(),i=e.config.chromosomes[t]):i=c.chromosomes,s=r.filter((t=>i.includes(t.name))),e.config.chromosomes[t]=s),e.chromosomes[t]=e.config.chromosomes[t].slice(),e.organisms[t].assemblies={default:o},n()}))}function Wc(t,n){var e,o;for(e in n.organisms)if(o=n.organisms[e],e===ra(t)||ra(o.commonName)===ra(t)||ra(o.scientificName)===ra(t))return!0;return!1}function Uc(t,n){(function(t){var n,e,o,r,i,a=t.config;return n=[],e={},function(t,n){var e,o,r,i=[],a={};for(r=0;r<t.length;r++)o=!1===Wc(e=t[r],n)?Hc(e,n).then((function(t){var e,o,r=t[1];o=(e=t[0].replace("-"," "))[0].toUpperCase()+e.slice(1),a[r]={scientificName:o,commonName:"",assemblies:{default:""}},Object.assign(n.organisms,a)}),(function(t){console.warn(t);var o={scientificName:e,commonName:e,assemblies:{default:""}};n.organisms[-1]=o,a[-1]=o})):new Promise((function(t){var o=n.getTaxid(e);a[o]=n.organisms[o],t()})),i.push(o);return Promise.all(i).then((function(){return a}))}(a.multiorganism?a.organism:[a.organism],t).then((function(t){var s=t[r];for(r in t)s=t[r],n.push(r),a.multiorganism&&(void 0!==a.chromosomes?(i=Object.keys(a.chromosomes).map((t=>ra(t))),i.includes(ra(s.scientificName))?o=s.scientificName:i.includes(ra(s.commonName))&&(o=s.commonName),ra(o)in a.chromosomes?e[r]=a.chromosomes[ra(o)]:e[r]=a.chromosomes[o.toLowerCase()]):e=null);return[e,n]}))})(n).then((function([e,o]){var r,i,a,s,c,l=n.config,u=[];for(r=0;r<o.length;r++)i=o[r],s=n.organisms[i].assemblies,c=Object.values(s),""===s.default||n.assemblyIsAccession()&&!c.includes(l.assembly)?a=new Promise((function(t){zc(i,t,n)})):(n.config.taxids=o,n.config.multiorganism&&(n.config.chromosomes=e),a=new Promise((function(t){t()}))),u.push(a);Promise.all(u).then((function(){return o=function(t){var n,e,o;if(n=t.config.organism,e=[],Array.isArray(n))for(o=0;o<n.length;o++)e.push(t.getTaxid(n[o]));else e.push(t.getTaxid(n));return e}(n),n.config.taxids=o,t(o)}))}))}function Yc(t){var n,e=this;if(n="taxid"in e.config,e.config.multiorganism=function(t,n){return"organism"in n.config&&n.config.organism instanceof Array||t&&n.config.taxid instanceof Array}(n,e),e.config.multiorganism&&(e.coordinateSystem="bp"),"organism"in e.config){const n=e.config.organism;"string"==typeof n&&(e.config.organism=ra(n.toLowerCase())),Uc(t,e)}else!function(t,n,e){var o;e.config.multiorganism?t&&(o=e.config.taxid):(t&&(o=[e.config.taxid]),e.config.taxids=o),n(o)}(n,t,e)}function Xc(t,n){var e,o;return[e,o]=function(t,n){var e=t.genome;return"mitochondrion"===e?function(t,n){var e,o;return n.config.showNonNuclearChromosomes?(e=t.genome,[-1===(o=t.subtype.split("|").indexOf("plasmid"))?"MT":t.subname.split("|")[o],e]):[null,null]}(t,n):"chloroplast"===e||"plastid"===e?function(t){return t.config.showNonNuclearChromosomes?["CP","chloroplast"]:[null,null]}(n):"apicoplast"===e?function(t){return t.config.showNonNuclearChromosomes?["AP","apicoplast"]:[null,null]}(n):function(t){var n,e;return n=t.subtype.split("|").indexOf("chromosome"),void 0!==(e=t.subname.split("|")[n])&&"chr"===e.substr(0,3)&&(e=e.substr(3)),[e,"nuclear"]}(t)}(t,n),{name:e,length:t.slen,type:o}}function Vc(t,n){var e,o=this,r=function(t,n){var e;return e=n.assemblyIsAccession()?n.config.assembly+"%22[Assembly%20Accession]":t+"%22[taxid]AND%20(%22latest%20refseq%22[filter])%20",n.esearch+"&db=assembly&term=%22"+e+"AND%20(%22chromosome%20level%22[filter]%20OR%20%22complete%20genome%22[filter])"}(t,o);Wi.json(r).then((function(t){return function(t,n){var e,o;return e=t.esearchresult.idlist[0],o=n.esummary+"&db=assembly&id="+e,Wi.json(o)}(t,o)})).then((function(t){var n=t.result.uids[0];return e=t.result[n],function(t,n){var e;return e="&db=nuccore&dbfrom=assembly&linkname=assembly_nuccore&cmd=neighbor_history&from_uid="+t,Wi.json(n.elink+e).then((function(t){var o=t.linksets[0].webenv;return e="&db=nuccore&term=%231+AND+%28sequence_from_chromosome[Properties]+OR+sequence_from_plastid[Properties]+OR+sequence_from_mitochondrion[Properties]%29&WebEnv="+o+"&usehistory=y&retmax=1000",n.esearch+e}))}(n,o)})).then((function(t){return Wi.json(t)})).then((function(t){return function(t,n){var e,o;return 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r,i,a,s,c,l=0,u=n.id.split("-")[1],h=o.coordinateSystem,f=o.config.chrHeight;for(r=0;r<t.length;r++)a=(i=t[r])[h].stop-i[h].start,o._layout._isRotated?s=f*a/n.length:(c="relative"===o.config.chromosomeScale?o.maxLength[u][h]:o.maxLength[h],s=f*n.length/c*a/n.length),t[r].px={start:l,stop:l+s,width:s},l=t[r].px.stop,e&&"acen"===i.stain&&"p"===i.name[0]&&(n.pcenIndex=r);return[t,n,l]}(n,t,r,s):(i="relative"===s.config.chromosomeScale?s.maxLength[a][s.coordinateSystem]:s.maxLength[s.coordinateSystem],o=e*t.length/i),t.width=o,t.scale=function(t,n,e){var o=e.config.chrHeight,r=t.length,i=e.maxLength,a=t.id.split("-")[1],s={};return s.bp=o/i.bp,!0===e.config.multiorganism?"relative"===e.config.chromosomeScale?(s.iscn=o*r/i[a].bp,s.bp=o/i[a].bp):s.iscn=o*r/i.bp:n&&(s.iscn=o/i.iscn),s}(t,r,s),t.bands=n,t}function hu(t,n,e,o){var r,i,a={},s=this;return r=void 0!==t,a=function(t,n,e,o){if(void 0!==n){const r=n.slice(-1)[0];t.name=e,t.length=r[o.coordinateSystem].stop,t.bpLength=r.bp.stop,t.type="nuclear"}else t=e;return t}(a,t,n,s),a.chrIndex=o,a.id="chr"+a.name+"-"+e,!0===s.config.fullChromosomeLabels&&(i=this.organisms[e],a.name=i.scientificName+" chr"+a.name),a.bands=t,(a=s.getChromosomePixels(a)).centromerePosition=function(t,n){if(!1===t)return"";const e=n[0],o=n.slice(-1)[0],r=(o.bp.stop-e.bp.start)/20;return"p"===e.name[0]&&"q"===n[1].name[0]&&e.bp.stop-e.bp.start<r?"telocentric-p":"p"===n.slice(-2)[0].name[0]&&"q"===o.name[0]&&o.bp.stop-o.bp.start<r?"telocentric-q":""}(r,t),a=function(t,n){return n&&1===t.bands.length&&delete t.bands,t}(a,r),a}function fu(t){t.forEach((t=>{t.classList.remove("active")}))}function du(){fu(document.querySelectorAll("#tools > ul > li")),document.querySelectorAll(".ideo-modal, .ideo-tool-panel").forEach((t=>{t.remove()})),document.querySelector("#tools").style.display="none"}function mu(t){const n=document.querySelectorAll("#tools > ul > 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e=t.toElement,r=e.id,i=document.querySelector(".ideo-tool-panel");document.querySelector("#tools").contains(e)&&i&&!i.contains(e)&&r!==n&&(fu(o),i.remove())}))}(o,i,e,n),"download"===i&&(document.querySelector("#download-image").addEventListener("click",(n=>{du(),function(t){var n=document.querySelector(t.selector),e="_ideo-undisplayed-dl-canvas";(o=document.createElement("canvas")).setAttribute("style","display: none"),o.setAttribute("id",e);var o,r=n.width.baseVal.value+30,i=n.cloneNode(!0);i.style.left="",o.setAttribute("width",r),document.body.appendChild(o),(o=document.getElementById(e)).width*=2,o.height*=2;var a=o.getContext("2d");a.setTransform(2,0,0,2,0,0),a.imageSmoothingEnabled=!1;var s=(new XMLSerializer).serializeToString(i),c=window.URL||window.webkitURL||window,l=new Image,u=new Blob([s],{type:"image/svg+xml;charset=utf-8"}),h=c.createObjectURL(u);l.onload=function(){var 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absolute;\n      right: 3px;\n      top: 24px;\n      z-index: 8001;\n      cursor: pointer;\n      height: 18px;\n      width: 18px;\n    }\n\n    #tools {\n      position: absolute;\n      width: 120px;\n      right: 27px;\n      top: 16px;\n      z-index: 8000;\n      background: white;\n      margin: 0;\n      border: 1px solid #CCC;\n      border-radius: 4px;\n      box-shadow: -2px 4px 6px #CCC;\n    }\n\n    #tools ul {\n      margin-block-start: 0;\n      margin-block-end: 0;\n      padding-inline-start: 0;\n    }\n\n    #tools li, #download li {\n      padding: 2px 12px 2px 12px;\n      cursor: pointer;\n    }\n\n    #tools li:hover,\n    #tools li.active,\n    #download li:hover {\n      background: #DDD;\n    }\n\n    #tools li.ideo-disabled,\n    #tools li.active.ideo-disabled,\n    #download li.ideo-disabled {\n      background: #FFF;\n      color: #CCC;\n      cursor: default;\n    }\n\n    #download {\n      position: absolute;\n      right: 3px;\n      top: 16px;\n      z-index: 8000;\n      background: white;\n      margin: 0;\n      padding-inline-start: 0;\n    }\n\n    #settings {\n      position: absolute;\n      right: 3px;\n      top: 16px;\n      z-index: 8000;\n      background: white;\n      margin: 0;\n      padding-inline-start: 0;\n    }\n\n    #about {\n      position: absolute;\n      right: 24px;\n      top: -8px;\n      z-index: 8000;\n      background: white;\n      width: 300px;\n      border: 1px solid #CCC;\n      padding: 10px;\n      border-radius: 4px;\n      box-shadow: -2px 4px 6px #CCC;\n      cursor: default;\n    }\n\n    #close {\n      float: right;\n      border: 1px solid #DDD;\n      border-radius: 4px;\n      padding: 0 6px;\n      background: #EEE;\n      font-weight: bold;\n      cursor: pointer;\n    }\n\n    #settings label {\n      display: inline;\n      text-decoration: underline;\n      text-decoration-style: dotted;\n      cursor: pointer;\n    }\n\n    #download {\n      position: absolute;\n      width: 120px;\n      top: -2px;\n      right: 120px;\n      z-index: 8000;\n      background: white;\n      margin: 0;\n      border: 1px solid #CCC;\n      border-radius: 4px;\n      box-shadow: -2px 4px 6px #CCC;\n    }\n\n    li {\n      list-style-type: none;\n    }\n\n    #settings .no-underline {\n      text-decoration: none;\n    }\n\n    #settings .setting {\n      margin-right: 8px;\n    }\n\n    #settings input[type="checkbox"], #settings input[type="radio"] {\n      position: relative;\n      top: 2px;\n    }\n\n    .area-header {\n      font-size: 16px;\n      font-weight: bold;\n      margin-bottom: 10px;\n      clear: both;\n    }\n\n    .area-content {\n      display: flex;\n      flex-wrap: wrap;\n    }\n\n    .area-content > div {\n      margin-right: 30px;\n      margin-bottom: 15px;\n    }\n\n    .tab-panel input[type="number"] {\n      width: 50px;\n    }\n\n    .tab-panel ul {\n      width: 600px;\n      list-style: none;\n      border-bottom: 1px solid #CCC;\n      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n=document.querySelector(t.selector),e=document.querySelector("#gear"),o=document.querySelector("#tools");n.addEventListener("mouseover",(()=>e.style.display="")),n.addEventListener("mouseout",(()=>{"none"===o.style.display&&(e.style.display="none")})),e.addEventListener("mouseover",(()=>e.style.display=""))}(t)}class gu{constructor(t){this._model=t,this._class="ModelAdapter"}static getInstance(t){return t.bands?new gu(t):new yu(t)}getModel(){return this._model}getCssClass(){return""}}class yu extends gu{constructor(t){super(t),this._class="ModelNoBandsAdapter"}getModel(){this._model.bands=[];const t="MT"===this._model.name,n=this._model.width;return(n>1||t)&&this._model.bands.push({name:"q",px:{start:0,stop:n,width:n},bp:{start:1,stop:this._model.bpLength??this._model.length},iscn:{start:1,stop:this._model.length}}),this._model}getCssClass(){return"noBands"}}class vu{constructor(t){this._config=t,this._ploidy=new es(this._config)}getArmColor(t,n,e){return this._config.armColors?this._config.armColors[e]:this._config.ancestors?this._getPolyploidArmColor(t,n,e):null}getBorderColor(t,n,e){const o=this._config,r=o.chrBorderColor?o.chrBorderColor:"#000";return n<o.ploidy||this._ploidy.exists(t,n,e)?r:"#fff"}getFillColor(){const t=this._config;if(!t.chrFillColor)return"#AAA";const n=t.chrFillColor;return"string"==typeof n?{arm:n,centromere:""}:n}_getPolyploidArmColor(t,n,e){if(this._ploidy.exists(t,n,e)){var o=this._ploidy.getAncestor(t,n,e);return this._config.ancestors[o]}return"transparent"}}class bu{constructor(t){this._data=t,this.start=t.start,this.stop=t.stop,this.length=this.stop-this.start}getColor(t){return"ploidy"in this._data?"ploidy"in this._data&&this._data.ploidy[t]?this._getColor(t):"transparent":this._getColor(t)}_getColor(t){return Array.isArray(this._data.color)?this._data.color[t]:this._data.color}}class wu{constructor(t,n,e){this._adapter=t,this._model=this._adapter.getModel(),this._config=n,this._ideo=e,this._color=new vu(this._config),this._bumpCoefficient=5}static getInstance(t,n,e){const o=t.getModel().centromerePosition;return"telocentric-p"===o?new xu(t,n,e):"telocentric-q"===o?new Au(t,n,e):new _u(t,n,e)}_addPArmShape(t,n){return n?t.concat(this._getPArmShape()):t}_addQArmShape(t,n){return n?t.concat(this._getQArmShape()):t}render(t,n,e){var o,r,i,a,s,c,l;let u;if(o=this,t=t.append("g").attr("class","bands").attr("clip-path","url(#"+this._model.id+"-chromosome-set-clippath)"),r=this._renderArm(t,n,e,"p"),i=this._renderArm(t,n,e,"q"),this._renderRangeSet(t,n,e),a=[],a=this._addPArmShape(a,r),a=this._addQArmShape(a,i),s="0",c="",l=this.isFullyBanded(),"ancestors"in this._ideo.config&&!("rangeSet"in this._ideo.config)?(c=o._color.getArmColor(n,e,0),l&&(s="0.5")):l?(s=null,c="transparent"):"ancestors"in this._ideo.config||(s="1"),this._ideo.config.chrFillColor){const t=o._color.getFillColor();c=t.arm,u=t.centromere}return t.append("g").attr("class","chromosome-border").selectAll("path").data(a).enter().append("path").attr("fill",c).style("fill-opacity",s).style("fill",(function(t){if("acen"===t.class&&u)return u})).attr("stroke",(function(t,r){return o._color.getBorderColor(n,e,r)})).attr("stroke-width",(function(t){return"strokeWidth"in t?t.strokeWidth:1})).attr("d",(function(t){return t.path})).attr("class",(function(t){return t.class})),a}_renderRangeSet(t,n,e){var o,r,i,a;"rangeSet"in this._config&&(r=this._config.rangeSet.filter((function(t){return t.chr-1===n})).map((function(t){return new bu(t)})),i=t.append("g").attr("class","range-set"),a=(o=this)._ideo,i.selectAll("rect.range").data(r).enter().append("rect").attr("class","range").attr("x",(function(t){return a.convertBpToPx(o._model,t.start)})).attr("y",0).attr("width",(function(t){return a.convertBpToPx(o._model,t.length)})).attr("height",this._config.chrWidth).style("fill",(function(t){return t.getColor(e)})))}_getShapeData(){var t,n,e,o;for(n=0;n<this._model.bands.length;n++)if("q"===this._model.bands[n].name[0]){t=this._model.bands[n];break}return e=this._model.bands.length-1,o=this._model.bands[e].px.stop,{x1:0,x2:t?t.px.start:o,x3:o,w:this._config.chrWidth,b:this._config.chrWidth/this._bumpCoefficient}}_getPArmShape(){var t=this._getShapeData(),n=t.x2-t.b;return this.isFullyBanded()||"ancestors"in this._ideo.config?{class:"",path:"M"+t.b+",0 L"+n+",0 Q"+(t.x2+t.b)+","+t.w/2+","+n+","+t.w+" L"+t.b+","+t.w+" Q-"+t.b+","+t.w/2+","+t.b+",0"}:[{class:"",path:"M"+t.b+",0 L"+(n-2)+",0 L"+(n-2)+","+t.w+" L"+t.b+","+t.w+" Q-"+t.b+","+t.w/2+","+t.b+",0"},{class:"acen",path:"M"+n+",0 Q"+(t.x2+t.b)+","+t.w/2+","+n+","+t.w+" L"+n+","+t.w+" L"+(n-2)+","+t.w+" L"+(n-2)+",0"}]}_getQArmShape(){var t=this._getShapeData(),n=t.x3-t.b,e=t.x2+t.b;return this.isFullyBanded()||"ancestors"in this._ideo.config?{class:"",path:"M"+e+",0 L"+n+",0 Q"+(t.x3+t.b)+","+t.w/2+","+n+","+t.w+" L"+e+","+t.w+" Q"+(t.x2-t.b)+","+t.w/2+","+e+",0"}:[{path:"M"+e+",0 L"+n+",0 Q"+(t.x3+t.b)+","+t.w/2+","+n+","+t.w+" L"+e+","+t.w+" L"+e+",0"},{class:"acen",path:"M"+e+",0Q"+(t.x2-t.b)+","+t.w/2+","+e+","+t.w+" L"+e+","+t.w+"L"+(e+2)+","+t.w+"L"+(e+2)+",0"}]}isFullyBanded(){return this._model.bands&&(2!==this._model.bands.length||"q"===this._model.bands[0].name[0])}_renderBands(t,n,e,o,r){var i,a,s;a="p"===r?0:1,s="","ancestors"in(i=this)._ideo.config&&!i.isFullyBanded()&&(s=i._color.getArmColor(n,e,a)),t.selectAll("path.band."+r).data(o).enter().append("path").attr("id",(function(t){return i._model.id+"-"+t.name.replace(".","-")})).attr("class",(function(t){return"band "+r+"-band "+t.stain})).attr("d",(function(t){var n;return"M "+i._ideo.round(t.px.start)+", 0l "+(n=i._ideo.round(t.px.width))+" 0 l 0 "+i._config.chrWidth+" l -"+n+" 0 z"})).style("fill",s)}_renderArm(t,n,e,o){var r=this._model.bands.filter((function(t){return t.name[0]===o}));return this._renderBands(t,n,e,r,o),Boolean(r.length)}}class _u extends wu{constructor(t,n,e){super(t,n,e),this._class="MetacentricChromosome"}}class xu extends wu{constructor(t,n,e){super(t,n,e),this._class="TelocentricPChromosome",this._pArmOffset=3}_addPArmShape(t){return t.concat(this._getPArmShape())}_getPArmShape(){var t=this._getShapeData();return t.o=this._pArmOffset,[{class:"acen",path:"M"+(t.x2+2)+",1L"+(t.x2+t.o+3.25)+",1 L"+(t.x2+t.o+3.25)+","+(t.w-1)+" L"+(t.x2+2)+","+(t.w-1)},{class:"gpos66",path:"M"+(t.x2-t.o+5)+",0L"+(t.x2-t.o+3)+",0 L"+(t.x2-t.o+3)+","+t.w+" L"+(t.x2-t.o+5)+","+t.w,strokeWidth:.5}]}_getQArmShape(){var t=this._getShapeData(),n=t.x3-t.b,e=this._pArmOffset+3;return{class:"",path:"M"+(t.x2+e)+",0 L"+n+",0 Q"+(t.x3+t.b)+","+t.w/2+","+n+","+t.w+" L"+(t.x2+e)+","+t.w}}}class Au extends wu{constructor(t,n,e){super(t,n,e),this._class="TelocentricQChromosome",this._qArmOffset=3}_getPArmShape(){var t=this._getShapeData(),n=t.x3-t.b,e=this._qArmOffset;return{class:"",path:"M"+(t.x2+e)+",0 L"+(n+e)+",0 L"+(n+e)+","+t.w+" L"+t.b+","+t.w+" Q-"+t.b+","+t.w/2+","+t.b+",0"}}_addQArmShape(t){return t.concat(this._getQArmShape())}_getQArmShape(){var t=this._getShapeData();return t.o=this._qArmOffset,[{class:"acen",path:"M"+(t.x2+2)+",1 L"+(t.x2+t.o+3.25)+",1 L"+(t.x2+t.o+3.25)+","+(t.w-1)+" L"+(t.x2+2)+","+(t.w-1)},{class:"gpos66",path:"M"+(t.x2+t.o+5)+",0 L"+(t.x2+t.o+3)+",0 L"+(t.x2+t.o+3)+","+t.w+" L"+(t.x2+t.o+5)+","+t.w,strokeWidth:.5}]}}function Cu(t,n,e,o){var r,i,a,s,c;s=Wi.select(this.selector+" defs"),c=gu.getInstance(t),r=e*this.config.chrMargin,i=o.append("g").attr("id",t.id).attr("class","chromosome "+c.getCssClass()).attr("transform","translate(0, "+r+")"),a=wu.getInstance(c,this.config,this).render(i,n,e),Wi.select("#"+t.id+"-chromosome-set-clippath").remove(),s.append("clipPath").attr("id",t.id+"-chromosome-set-clippath").selectAll("path").data(a).enter().append("path").attr("d",(function(t){return t.path})).attr("class",(function(t){return t.class})),t.width<1&&Wi.select("#"+t.id+" .bands").style("opacity",0)}function Su(t){var n,e,o,r,i,a;if(n=t.chrIndex,r=this._layout.getChromosomeSetTranslate(n),a=this.selector+" #"+t.id+"-chromosome-set",Wi.selectAll(a+" g").remove(),0===(e=Wi.select(a)).nodes().length&&(e=Wi.select(this.selector).append("g").attr("class","chromosome-set").attr("transform",r).attr("id",t.id+"-chromosome-set")),"sex"in this.config&&2===this.config.ploidy&&this.sexChromosomes.index===n)this.drawSexChromosomes(e,n);else for(o=1,this.config.ploidy>1&&(o=this._ploidy.getChromosomesNumber(n)),i=0;i<o;i++)this.appendHomolog(t,n,i,e)}function ku(t){var n,e;this.unhighlight(),this.config.taxid&&(n=t.id.split("-")[0].replace("chr",""),e=this.chromosomes[this.config.taxid][n].chrIndex,this._layout.rotate(e,e,t))}function Tu(){var t,n,e,o,r,i,a,s;n=(t=this).config,i=Wi.select(n.container+" svg#_ideogram"),o=Wi.select(n.container+" #_ideogramInnerWrap"),r=Wi.select(n.container+" #_ideogramMiddleWrap"),s=1===(a=n.ploidy)?a:1.12*a;let c=0;"annotationsLayout"in n&&(c=n.annotationHeight*n.numAnnotTracks),"vertical"===n.orientation&&"comparative"!==n.perspective&&"collinear"!==n.geometry&&(e=t.numChromosomes*(n.chrWidth+n.chrMargin+c),"heatmap-2d"!==n.annotationsLayout&&(e=Math.ceil(e*s/n.rows),"SmallLayout"===t._layout._class&&(e+=100),e+=35,r.style("height",t._layout.getHeight()+"px"),o.style("max-width",e+"px").style("overflow-x","scroll").style("position","absolute"),i.style("min-width",e-5+"px"),t.config.showTools&&pu(t)))}function Lu(){(function(t){var n=t._layout;Wi.selectAll(t.selector+" .chromosome-set").insert("text",":first-child").data(t.chromosomesArray).attr("class",n.getChromosomeLabelClass()).attr("transform",n.getChromosomeSetLabelTranslate()).attr("x",n.getChromosomeSetLabelXPosition()).attr("y",(function(t,e){return n.getChromosomeSetLabelYPosition(e)})).attr("text-anchor",n.getChromosomeSetLabelAnchor()).each((function(n,e){!function(t,n,e,o){var r=function(t,n,e){var o;return o=-1===t.name.indexOf(" ")?[t.name]:t.name.match(/^(.*)\s+([^\s]+)$/).slice(1).reverse(),"sex"in e.config&&2===e.config.ploidy&&n===e.sexChromosomes.index&&(o="male"===e.config.sex?["XY"]:["XX"]),o}(t,n,o);Wi.select(e).selectAll("tspan").data(r).enter().append("tspan").attr("dy",(function(t,n){return-1.2*n+"em"})).attr("x",o._layout.getChromosomeSetLabelXPosition()).attr("class",(function(t,n){var e=o.config.fullChromosomeLabels;return 1===n&&e?"italic":null})).text(String)}(n,e,this,t)}))})(this),function(t){var n=t._layout;Wi.selectAll(t.selector+" .chromosome-set").each((function(e,o){Wi.select(this).selectAll(".chromosome").append("text").attr("class","chrLabel").attr("transform",n.getChromosomeSetLabelTranslate()).attr("x",(function(t,e){return n.getChromosomeLabelXPosition(e)})).attr("y",(function(t,e){return n.getChromosomeLabelYPosition(e)})).text((function(n,e){return t._ploidy.getAncestor(o,e)})).attr("text-anchor","middle")}))}(this)}function Mu(t,n,e,o){var r;n-=1,r=function(t){var n,e,o;return void 0===t||!t.hasOwnProperty("x")||1===t.x&&1===t.y?(n=-8,e=-16,t={x:1,y:1},o=""):(o="scale("+t.x+","+t.y+")",n=-6,e=""===t?-16:-14),{x:n,y:e,scaleSvg:o,scale:t}}(o),"vertical"===e||""===e?function(t,n,e,o){var r,i,a,s=o.config;n=function(t,n){return(n.numAnnotTracks>1||""===n.orientation)&&(t-=1),t}(n,s),r=-4,!0===s.showBandLabels&&(r=s.chrMargin+s.chrWidth+26),i=s.chrMargin*n,s.numAnnotTracks>1==0&&(i+=1),a=i+r,t.selectAll("text.chrLabel").attr("transform",e.scaleSvg).selectAll("tspan").attr("x",e.x).attr("y",a)}(t,n,r,this):function(t,n,e,o){var r,i,a,s=o.config;r=-s.chrWidth-2,!0===s.showBandLabels&&(r=s.chrMargin+8),i=s.annotTracksHeight,"overlay"!==s.annotationsLayout&&(i*=2),a=3-(s.chrMargin*n+r)+i,a/=e.scale.x,t.selectAll("text.chrLabel").attr("transform","rotate(-90)"+e.scaleSvg).selectAll("tspan").attr("x",a).attr("y",e.y)}(t,n,r,this)}function Eu(t){return Math.round(performance.now()-t)}function Nu(){const t=this.annotDescriptions.annots,n=Object.values(t).slice(),e=n.filter((t=>t.type&&t.type.includes("paralogous"))),o=n.filter((t=>t.type&&t.type.includes("interacting gene")));return{related:n,paralogous:e,interacting:o,searched:Object.entries(t).filter((t=>t[1].type&&t[1].type.includes("searched gene")))[0][0]}}function Pu(t){const n=this,e=performance.now()-n.time.prevTooltipOff,o=n.time.prevTooltipAnnotDomId;if(e<300&&t.domId===o)return null;const r=t.name,i=n.annotDescriptions.annots[t.name].type.split(" ")[0],a=Du(n);return Object.assign({tooltipGene:r,tooltipRelatedType:i},a)}function Du(t){const n=t.getRelatedGenesByType();return{numRelatedGenes:n.related.length,numParalogs:n.paralogous.length,numInteractingGenes:n.interacting.length,searchedGene:n.searched}}const Bu="#CAA",Iu="#866",Fu="#99D",$u="#22C",Ru="#CCF",Gu="#33D",Ou="#93E9BE",ju="#53AC7E",Hu="#FFA500",qu="#DD8000";function zu(t,n,e){const o=t[0],r=t[3];let i=n.px.start+r.x;const a=r.width;e||(i=n.px.length+n.px.start-(r.x+r.width));const s=`${t[2]}&nbsp;aa`,c=`data-subpart="${o} ${Wu} ${s}"`,l=`x="${i}" width="${a}" y="40" height="10"`,[u,h]=function(t){return t.includes("conserved site")?["#922D5E","#D26D9E"]:t.includes("active site")||t.includes("hydroxylation site")||t.includes("Lipid transport")?["#F00","#D00"]:t.includes("catalytic domain")||t.includes("kinase domain")||"PIK-related kinase, FAT"===t||t.includes("trypsin domain")||"Transforming growth factor-beta, C-terminal"===t||"Cyclin, C-terminal domain"===t||t.includes("OB C-terminal domain")||"Cationic amino acid transporter, C-terminal"===t||"High mobility group box domain"===t||t.includes("Peptidase M2")||t.includes("CUB domain")||"C-5 cytosine methyltransferase"===t||t.includes("(G-protein), alpha subunit")||"SCAN domain"===t||"Apolipoprotein A/E"===t||t.includes("SMAD domain")||"PLAC"===t||t.endsWith("tripeptidyl peptidase II")||"Prohormone convertase enzyme"===t?[Bu,Iu]:t.includes("binding site")||"EF-hand domain"===t||"Zinc finger, nuclear hormone receptor-type"===t||t.includes("Serpin domain")||"Peptidase C14,  p20 domain"===t||"PWWP domain"===t||"GPCR, rhodopsin-like, 7TM"===t||"Peptidoglycan binding-like"===t||"MAD homology 1, Dwarfin-type"===t?[Fu,$u]:t.includes("dehydrogenase, molybdopterin binding")||"Zinc finger CCHC HIVEP-type"===t||"Cyclin, N-terminal"===t||"MAD homology, MH1"===t||"Sodium ion transport-associated"===t?[Ru,Gu]:t.includes("binding domain")||t.includes("zinc-binding")||t.includes("DNA-binding")||"G protein-coupled receptor, rhodopsin-like"===t||t.includes("Homeobox domain")||t.includes("Ion transport domain")||t.includes("BRCT domain")||t.includes("transactication domain")||t.includes("EF-hand")||"Laminin G domain"===t||"Peptidase C14, caspase non-catalytic subunit p10"===t||"ADD domain"===t||"PDZ domain"===t||"Krueppel-associated box"===t||"Ets domain"===t||"P domain"===t?["#55A","#AAF"]:"SH2 domain"===t||t.includes("Furin-like")||t.includes("heparin-binding")||"SRCR domain"===t||"EGF-like domain"===t||t.includes("EGF domain")||"Basic leucine zipper domain, Maf-type"===t||t.includes("Interleukin")&&t.includes("propeptide")||"Sirtuin family"===t||"Amino acid/polyamine transporter I"===t||"Peptidase M10, metallopeptidase"===t||"Zinc finger C2H2-type"===t?["#7D7","#5B5"]:"SH3 domain"===t||t.includes("copper-binding")||"Sushi/SCR/CCP domain"===t||t.includes("Receptor L-domain")||t.includes("Coagulation factor 5/8")||"Basic-leucine zipper domain"===t||t.includes("Interleukin")&&t.includes("family")||"Sirtuin family, catalytic core domain"===t||"Amine oxidase"===t||t.includes("lid domain")||t.includes("prodomain")?[Ou,ju]:"Immunoglobulin-like domain"===t||"Major facilitator superfamily domain"===t||t.includes("interface")?["#FFC0CB","#CF909B"]:"Immunoglobulin"===t||"Calponin homology domain"===t||t.includes("ATPase")||t.includes("globular domain")||"Mitochondrial substrate/solute carrier"===t||"Major facilitator,  sugar transporter-like"===t||"Sodium:neurotransmitter symporter"===t||"Fibronectin type III"===t?["#D7A1F9","#A771C9"]:"Immunoglobulin C1-set"===t||t.includes("GTPase")||"Major facilitator superfamily"===t||"Fibronectin type II domain"===t||t.includes("ectodomain")||t.endsWith("receptor domain")||t.endsWith("receptor domain 4")?["#B24BF3","#921BC3"]:"Immunoglobulin C2-set"===t||t.includes("immunoglobulin C2-set")||t.includes("protein interaction")?["#880ED4","#5800A4"]:"Immunoglobulin V-set domain"===t?["#51087E","#8138AE"]:"Immunoglobulin I-set"===t?["#A020F0","#7000C0"]:"Armadillo"===t||t.includes("Apple domain")||"Protocadherin"===t||t.endsWith("merisation domain")?[Hu,qu]:t.includes("Kringle")||t.includes("Peptidase M12A")||"TGF-beta, propeptide"===t||"PIK-related kinase"===t||t.includes("(PIK) domain")||"LDLR class B repeat"===t||"Cadherin-like"===t||"Actin family"===t?["#DACDBA","#BAAB9A"]:t.includes("transmembrane domain")||t.includes("Transmembrane protein")||t.includes("Collectrin")||t.includes("cytoplasmic domain")?["#964B00","#C67B30"]:"CARD domain"===t||"Death effector domain"===t||"Death domain"===t||"Ubiquitin-associated domain"===t||t.includes("UBA 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n=Ju(),e=t.querySelector("svg").getAttribute("data-ideo-footer");n.innerHTML=`&nbsp;<br/>${e}`}function th(t,n=0){const[e,o]=eh(t,n),r=0===o;document.querySelector("#_ideoGeneStructureMenu").options[o].selected=!0;const i=_h(e,t,t.spliceExons)[0],a=document.querySelector("._ideoGeneStructureSvgContainer");a.innerHTML=i,gh(t.spliceExons,r),Zu(a),t.addedSubpartListeners=!1,fh(t)}function nh(t){return t.split("-").slice(0,-1).join("-")}function eh(t,n=0){let e,o;const r=document.querySelector("#_ideoGeneStructureMenu");if(r){const t=r.options.length;e=r.selectedIndex+n,e>=t?e=0:e<0&&(e=t-1),o=r.options[e].value}else{const t=document.querySelector("._ideoGeneStructure");if(!t)return null;o=t.getAttribute("data-ideo-gene-structure-name"),e=0}const i=nh(o);return[t.geneStructureCache[i].find((t=>t.name===o)),e]}function oh(t){if("s"===t.key){const t=document.querySelector("._ideoSpliceToggle input");if(!t)return;const 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e=la(n.relatedAnnots);e=Dh(e,n),e=Rh(e),n.relatedAnnots=Rh(e),n.relatedAnnots.sort(n.annotSortFunction),e.length>1&&n.onFindGenesCallback&&n.onFindGenesCallback(),n.drawAnnots(e),n.config.showAnnotLabels&&n.fillAnnotLabels(n.relatedAnnots),Ph(),function(t,n){if("pathway"===t)return;const e=n.getRelatedGenesByType(),o={paralogous:"interacting",interacting:"paralogous"}[t],r=e[t].length,i=e[o]?e[o].length:0;if(n._didRelatedGenesFirstPlot)if(r>0&&i>0){const t=n.time.rg.timestampFirstPlot;n.time.rg.totalLastPlotDiff=Eu(t)}else r>0&&0===i?(n.time.rg.timestampFirstPlot=performance.now(),n.time.rg.totalFirstPlot=Eu(n.time.rg.t0),n._relatedGenesFirstPlotType=t,n.time.rg.totalLastPlotDiff=0):(0===r&&i>0||(n._relatedGenesFirstPlotType="searched"),n.time.rg.totalLastPlotDiff=0);else n._didRelatedGenesFirstPlot=!0,n.time.rg.totalFirstPlot=Eu(n.time.rg.t0),r>0&&(n.time.rg.timestampFirstPlot=performance.now(),n._relatedGenesFirstPlotType=t)}(t,n)}function Oh(t){var n=document.querySelector(t.config.container);n.style.visibility="",n.style.position="absolute",n.style.width="100%";var e=document.querySelector("#_ideogramInnerWrap");e.style.position="relative",e.style.marginLeft="auto",e.style.marginRight="auto",e.style.overflowY="hidden",document.querySelector("#_ideogramMiddleWrap").style.overflowY="hidden";const o=t.config.legendPad;if(void 0===t.didAdjustIdeogramLegend){var r=document.querySelector("#_ideogram");const n=160;e.style.maxWidth=parseInt(e.style.maxWidth)+n+o+"px",r.style.minWidth=parseInt(r.style.minWidth)+o+"px",r.style.maxWidth=parseInt(r.style.minWidth)+o+"px",r.style.position="relative",r.style.left=n+"px",t.didAdjustIdeogramLegend=!0}}async function jh(t=null){const n=this;if(!t)return Vh();n.clearAnnotLabels();const e=document.querySelector("#_ideogramLegend");e&&e.remove(),n.config=Yh(n.config),function(t,n){const e=[`# ${n}`,`# Organism: ${t.getScientificName(t.config.taxid)}`,`# Generated by Ideogram.js version ${Ideogram.version}, https://github.com/eweitz/ideogram`,`# Generated at ${window.location.href}`].join("\n");delete t.annotDescriptions,t.annotDescriptions={headers:e,annots:{}}}(n,`Related genes for ${t}`);const o=n.selector+" .annot";document.querySelectorAll(o).forEach((t=>t.remove())),n.startHideAnnotTooltipTimeout(),document.querySelectorAll(".chromosome").forEach((t=>{t.style.cursor=""})),Oh(n),n.relatedAnnots=[];const r=await async function(t,n){const e=performance.now(),o=await Lh(t,"symbol",n);if(0===o.hits.length)return;const r=o.hits.find((t=>{const e=Eh(t,n);return e&&e.ensemblgene}));let i={description:"",ensemblId:r.genomic_pos.ensemblgene,type:"searched gene"};if(r.symbol in n.annotDescriptions.annots){const t=n.annotDescriptions.annots[r.symbol];i=Object.assign(t,i)}else i.name=r.name;n.annotDescriptions.annots[r.symbol]=i;const a=Nh(r,n);return n.relatedAnnots.push(a),n.time.rg.searchedGene=Eu(e),a}(t,n);void 0===r&&kh(t,n),n.config.legend=Wh,hc(n),Ph(),await Promise.all([Bh(r,n),Ih(r,n)]),n.time.rg.total=Eu(n.time.rg.t0),function(t){const n=Du(t),e=t.time.rg.total,o=t.time.rg.totalFirstPlot,r=t.time.rg.totalLastPlotDiff,i=t.time.rg.paralogs,a=t.time.rg.interactions,s=t.time.rg.searchedGene,c=t._relatedGenesFirstPlotType,l=Object.assign({firstPlotType:c,timeTotal:e,timeTotalFirstPlot:o,timeTotalLastPlotDiff:r,timeSearchedGene:s,timeInteractingGenes:a,timeParalogs:i},n);t.relatedGenesAnalytics=l}(n),n.onPlotFoundGenesCallback&&n.onPlotFoundGenesCallback()}function Hh(t){return Object.entries(t.annotDescriptions.annots).find((([t,n])=>"searched gene"===n.type))[0]}const qh="triangle";function zh(t){return`\n    <div style="position: relative; left: 30px;">\n      <div style="font-size: 14px; font-weight: bold; font-color: #333;">${t}</div>\n      <i>Click gene to search</i>\n    </div>\n  `}const Wh=[{name:zh("Related genes"),nameHeight:50,rows:[{name:"Interacting gene",color:"purple",shape:qh},{name:"Paralogous gene",color:"pink",shape:qh},{name:"Searched gene",color:"red",shape:qh}]}];zh("Related genes");const Uh=[{name:zh("Highly cited genes"),nameHeight:30,rows:[]}];function Yh(t){return t.legendPad=t.showAnnotLabels?70:30,t}const Xh={chrWidth:9,chrHeight:100,chrLabelSize:12,annotationHeight:7,showFullyBanded:!1,rotatable:!1,legend:Wh,chrBorderColor:"#333",chrLabelColor:"#333",onWillShowAnnotTooltip:function(t){var n;const e=this;if(t.name===(null===(n=e.prevClickedAnnot)||void 0===n?void 0:n.name)&&e.isTooltipCooling)return null;let o=e.annotDescriptions.annots[t.name];"related"===e.config.relatedGenesMode&&(o=function(t,n,e){if("type"in n&&n.type.includes("interacting gene")){const o=n.pathwayIds,r=Hh(e),i=e.gpmlsByInteractingGene[t.name],a=function(t,n,e,o){let r=null;if(!navigator.onLine)return"Interacts with";const i=function(t,n,e,o){const r={};return e.map((e=>{const i=o[e],a=function(t,n,e){const[o,r]=Ch(e,n),[i,a]=Ch(e,t),s={searchedGene:r,interactingGene:a},c=o.concat(i),l={searchedGeneGraphIds:o,matchingGraphIds:c},u=[],h=e.querySelectorAll("Interaction Graphics");return Array.from(h).forEach((t=>{const n=function(t,n){let e=null;const{searchedGeneGraphIds:o,matchingGraphIds:r}=n,i=[];let a=0,s=!1,c=null,l=null;return Array.from(t.children).forEach((t=>{if("Point"!==t.nodeName)return;const n=t,e=n.getAttribute("GraphRef");if(null!==e&&r.includes(e)&&(a+=1,i.push(e),o.includes(e)&&(s=!0),n.getAttribute("ArrowHead"))){const t=n.getAttribute("ArrowHead"),r=o.includes(e);null===l&&(l=r?0:1),c=xh[t][r?0:1]}})),a>=2&&s&&(null===l&&(c="interacts with"),c=c[0].toUpperCase()+c.slice(1),e={interactionId:t.parentNode.getAttribute("GraphId"),endIds:i,ixnType:c}),e}(t,l);null!==n&&(n.elements=s,u.push(n))})),u}(t,n,i);r[e]=a})),r}(t,n,e,o),a=i[e[0]];if(a.length>0){let t={ixnsByPwid:i,isSameByPwid:{},isSame:null,isDirectionSameByPwid:{},isDirectionSame:null,directionsByPwid:{}};t=function(t){let n=!0;const e=t.ixnsByPwid,o=Ah(e);return Object.entries(e).map((([e,r])=>{const{isRefMatch:i,thisIsSame:a}=function(t,n){let e=!0,o=!0;if(0===t.length)return{isRefMatch:e,thisIsSame:o};const r=t[0].ixnType.toLowerCase();return t.forEach((t=>{const i=t.ixnType.toLowerCase();i!==n&&(e=!1),i!==r&&(o=!1)})),{isRefMatch:e,thisIsSame:o}}(r,o);a&&i||(n=!1),t.isSameByPwid[e]=a})),t.isSame=n,t}(t),t.isSame?r=a[0].ixnType:(t=function(t){let n=!0;const e=[],o=[];Object.values(xh).forEach((t=>{o.push(t[0]),e.push(t[1])}));const r="Acts on",i="Acted on by",a=t.ixnsByPwid,s=Ah(a),c=o.includes(s)?r:i;return Object.entries(a).map((([e,a])=>{let s=!0;if(a.length>0){const l=a[0].ixnType.toLowerCase(),u=o.includes(l)?r:i;a.forEach((a=>{const l=a.ixnType.toLowerCase(),h=o.includes(l)?r:i;t.directionsByPwid[e]=h,h!==c&&(n=!1),h!==u&&(s=!1)}))}t.isDirectionSameByPwid[e]=s})),t.isDirectionSame=n,!0===n&&(t.direction=c),t}(t),r=t.isDirectionSame?t.direction:"Interacts with")}return r}(t.name,r,o,i);if(null!==a){const t="Interacts with";n.description=n.description.replace(t,a)}}return n}(t,o,e));const r=o.description.length>0?`<br/>${o.description}`:"",i=o.name,a='style="color: #0366d6; cursor: pointer;"';let s=i;"rank"in t&&(s=`<span title="${"Ranked "+t.rank+" in general or scholarly interest"}">${i}</span>`);const c=t.name.includes("paralogNeighborhood"),l=function(t,n,e){let o="";const r=t.name;if(n.config.showGeneStructureInTooltip&&!e&&"geneStructureCache"in n!=0&&r in n.geneStructureCache!=0){n.addedSubpartListeners=!1,"spliceExons"in n==0&&(n.spliceExons=!0);const t=n.spliceExons,e=_h(n.geneStructureCache[r][0],n,t)[0],i='class="_ideoGeneStructureContainer"',a=function(t){const n=t.spliceExons,e=n?"checked":"";return`<label class="_ideoSpliceToggle ${n?"":"pre-"}mRNA" style="position: relative; top: -5px; user-select: none; float: right; cursor: pointer; font-size: 16px; padding: 2px 4px; border: 1px solid #CCC; border-radius: 3px;" title="${mh(n)}"><input type="checkbox" ${e} style="display: none;" />&#x2702;</label>`}(n),s=`class="_ideoGeneStructureContainerName${t?"":" pre-mRNA"}"`,{name:c,title:l}=ph(t);o=`<br/><br/><style>\n  ._ideoGeneStructureContainerName {\n    margin-left: 81px;\n  }\n  ._ideoGeneStructureContainerName.pre-mRNA {\n    margin-left: 69px;\n  }\n  ._ideoGeneStructureContainer rect:hover + line {\n    visibility: hidden;\n  }\n  ._ideoGeneStructureContainer {\n    display: flex;\n    justify-content: center;\n    align-items: center;\n    flex-direction: column;\n  }\n  ._ideoGeneStructureContainer:hover ._ideoSpliceToggle {\n    visibility: visible;\n  }\n  ._ideoGeneStructureContainer ._ideoSpliceToggle {\n    visibility: hidden;\n  }\n  ._ideoSpliceToggle {\n    margin-left: 53px; background-color: #EEE;\n  }\n  ._ideoSpliceToggle.pre-mRNA {\n    margin-left: 43px; background-color: #F8F8F8;\n  }\n  ._ideoHoveredSubpart {\n    stroke: #D0D0DD !important; stroke-width: 3px;\n  }\n  </style><div ${i}><div><span ${s} title="${l}">${c}</span>${a}</div><span class="_ideoGeneStructureSvgContainer">`+e+'</span><div class="_ideoGeneStructureFooter"></div></div>'}return o}(t,e,c);let u=`<span id="ideo-related-gene" ${a}>${t.name}</span><br/>${s}<br/>`+r+l+"<br/>";return c&&([t,u]=function(t,n,e){const o=n.paralogs.sort(((t,n)=>t.rank-n.rank)),r=o.shift();o.push(r);const i="Paralog neighborhood<br/><br/>"+n.description+":<br/>"+`${o.map((t=>{let n="";return t.fullName&&(n=t.fullName),t.rank&&(n+=` &#013;Ranked ${t.rank} in general or scholarly interest`),""!==n&&(n=`title="${n}"`),`<span class="ideo-paralog-neighbor" ${n} style="color: #0366d6; cursor: pointer;"'>${t.name}</span>`})).join("<br/>")}<br/>`;return t.displayCoordinates=n.displayCoordinates,[t,i]}(t,o)),t.displayName=u,t},onDidShowAnnotTooltip:function(){!function(t){const n=document.querySelector("._ideogramTooltip");t.addedTooltipClickHandler||(n.addEventListener("click",(n=>{if(["input","label"].includes(n.target.localName))return;let e=document.querySelector("#ideo-related-gene");e||(e=n.target);const o=function(t,n){var e;return n.annots.forEach((n=>{n.annots.forEach((n=>{t===n.name&&(e=n)}))})),null===e&&(e=n.annotDescriptions.annots[t]),e}(e.textContent,t);t.onClickAnnot(o)})),t.addedTooltipClickHandler=!0)}(this),dh(this)},showTools:!0,showAnnotLabels:!0,chrFillColor:{centromere:"#DAAAAA"}};function Vh(){const t=this;if(!t||"annotDescriptions"in t)return;t.annotDescriptions={annots:{}},t.flattenAnnots().map((n=>{let e=[];"significance"in n&&"n/a"!==n.significance&&e.push(n.significance),"citations"in n&&void 0!==n.citations&&e.push(n.citations),e=e.join("<br/><br/>"),t.annotDescriptions.annots[n.name]={description:e,name:n.fullName}})),Oh(t),Ph(),t.fillAnnotLabels([]);const n=t.config.container;document.querySelector(n).style.visibility=""}function Qh(t,n,e){if("all"!==e&&(e=e.map((t=>t.toLowerCase()))),t.annotsInList=e,t.legendPad=t.showAnnotLabels?80:30,"onWillShowAnnotTooltip"in n){const e="onWillShowAnnotTooltip",o=n[e],r=t[e],i=function(t){return t=r.bind(this)(t),o.bind(this)(t)};t[e]=i,delete n[e]}if("onDidShowAnnotTooltip"in n){const e="onDidShowAnnotTooltip",o=n[e],r=t[e],i=function(t){return t=r.bind(this)(t),o.bind(this)(t)};t[e]=i,delete n[e]}if("onDrawAnnots"in n){const e="onDrawAnnots",o=n[e],r=t[e],i=function(){r&&r.bind(this)(),o.bind(this)()};t[e]=i,delete n[e]}const o=Object.assign(t,n),r=new Ideogram(o);var i;return n.onFindGenes&&(r.onFindGenesCallback=n.onFindGenes),n.onPlotFoundGenes&&(r.onPlotFoundGenesCallback=n.onPlotFoundGenes),r.getTooltipAnalytics=Pu,r.annotSortFunction=Fh,(i=r).time={rg:{t0:performance.now()}},"_didRelatedGenesFirstPlot"in i&&delete i._didRelatedGenesFirstPlot,r}class Kh{constructor(t){this.configure=ha,this.initDrawChromosomes=ps,this.onLoad=ys,this.handleRotateOnClick=gs,this.init=Cs,this.finishInit=ns,this.writeContainer=ls,this.onLoadAnnots=qs,this.onDrawAnnots=zs,this.processAnnotData=Nc,this.restoreDefaultTracks=Ac,this.updateDisplayedTracks=Cc,this.initAnnotSettings=Bc,this.fetchAnnots=$c,this.drawAnnots=fc,this.getHistogramBars=ac,this.drawHeatmaps=Os,this.deserializeAnnotsForHeatmap=Hs,this.fillAnnots=Rc,this.drawProcessedAnnots=dc,this.drawSynteny=xc,this.startHideAnnotTooltipTimeout=Us,this.showAnnotTooltip=Qs,this.onWillShowAnnotTooltip=Ys,this.onDidShowAnnotTooltip=Xs,this.onClickAnnot=Vs,this.setOriginalTrackIndexes=Sc,this.afterRawAnnots=Ic,this.downloadAnnotations=Dc,this.addAnnotLabel=ec,this.removeAnnotLabel=rc,this.fillAnnotLabels=oc,this.clearAnnotLabels=ic,this.flattenAnnots=Fc,this.highlight=Oc,this.unhighlight=jc,this.esearch="https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?retmode=json&api_key=7e33ac6a08a6955ec3b83d214d22b21a2808",this.esummary="https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?retmode=json&api_key=7e33ac6a08a6955ec3b83d214d22b21a2808",this.elink="https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?retmode=json&api_key=7e33ac6a08a6955ec3b83d214d22b21a2808",this.getOrganismFromEutils=qc,this.getTaxids=Yc,this.getAssemblyAndChromosomesFromEutils=Vc,this.drawBandLabels=ol,this.getBandColorGradients=il,this.processBandData=ul,this.setBandsToShow=tl,this.hideUnshownBandLabels=Qc,this.drawBandLabelText=nl,this.drawBandLabelStalk=el,this.onBrushMove=hl,this.onBrushEnd=fl,this.createBrush=dl,this.createClickCursor=pl,this.onCursorMove=ml,this.drawSexChromosomes=gl,this.setSexChromosomes=yl,this.convertBpToPx=vl,this.convertPxToBp=wl,this.unpackAnnots=au,this.packAnnots=su,this.initCrossFilter=cu,this.filterAnnots=lu,this.assemblyIsAccession=Ui,this.getDataDir=Vi,this.round=Qi,this.onDidRotate=Ki,this.getSvg=Ji,this.fetch=Zi,this.getTaxid=ta,this.getCommonName=na,this.getScientificName=ea,this.getChromosomeModel=hu,this.getChromosomePixels=uu,this.drawChromosomeLabels=Lu,this.rotateChromosomeLabels=Mu,this.appendHomolog=Cu,this.drawChromosome=Su,this.rotateAndToggleDisplay=ku,this.setOverflowScroll=Tu,this.plotRelatedGenes=jh,this.getRelatedGenesByType=Nu,this.configure(t)}static get version(){return"1.41.0"}static get d3(){return Wi}static async fetchEnsembl(t,n=null,e="GET"){const o={method:e};if(null!==n&&(o.body=JSON.stringify(n)),"GET"===e){const n=t.includes("&")?"&":"?";t+=n+"content-type=application/json"}else o.headers={"Content-Type":"application/json"};const r=await fetch(`https://rest.ensembl.org${t}`,o);return await r.json()}static getChrSortNamesAndTypes(t,n){var e,o,r,i,a,s,c,l,u,h;return"string"==typeof t||"chr"in t&&"annots"in t?(a="MT"===(e="string"==typeof t?t:t.chr),s="MT"===(o="string"==typeof n?n:n.chr),c="AP"===e,l="AP"===o,u=!(r="CP"===e)&&!a&&!c,h=!(i="CP"===o)&&!s&&!l):(e=t.name,o=n.name,r="chloroplast"===t.type,i="chloroplast"===n.type,a="mitochondrion"===t.type,s="mitochondrion"===n.type,c="apicoplast"===t.type,l="apicoplast"===n.type,u="nuclear"===t.type,h="nuclear"===n.type),[e,o,{aIsNuclear:u,bIsNuclear:h,aIsCP:r,bIsCP:i,aIsMT:a,bIsMT:s,aIsAP:c,bIsAP:l}]}static sortChromosomes(t,n){let[e,o,r]=Kh.getChrSortNamesAndTypes(t,n);const{aIsNuclear:i,bIsNuclear:a,aIsCP:s,bIsCP:c,aIsMT:l,bIsMT:u,aIsAP:h,bIsAP:f}=r;return i&&a?(ia(e)&&ia(o)&&(e=aa(e).toString(),o=aa(o).toString()),e.localeCompare(o,"en",{numeric:!0})):!i&&a||l&&c?1:s&&u?-1:h||l||s||!(u||c||f)?void 0:-1}static initRelatedGenes(t,n="all"){return function(t,n){const e="homo-sapiens"===ra(t.organism);return"leads"===t.relatedGenesMode&&(delete t.onDrawAnnots,delete t.relatedGenesMode),Qh(Object.assign({showParalogNeighborhoods:e,relatedGenesMode:"related",useCache:!0,awaitCache:!0},Xh),t,n)}(t,n)}static initGeneLeads(t,n="all"){return function(t,n){let e,o;return delete t.onPlotFoundGenes,t.legendName&&(Uh[0].name=zh(t.legendName)),t.legend=Uh,t.geneLeadsDE?(o="leads",e="annotations/gene_leads.tsv"):(o="hints",e="cache/homo-sapiens-top-genes.tsv"),Qh(Object.assign({relatedGenesMode:o,chrMargin:-4,annotationsPath:Yi(e),onDrawAnnots:Vh,useCache:!0},Xh),t,n)}(t,n)}}window.Ideogram=Kh;const Jh=Kh;return n})()}));
 //# sourceMappingURL=ideogram.min.js.map
\ No newline at end of file
diff --git a/dist/js/ideogram.min.js.LICENSE.txt b/dist/js/ideogram.min.js.LICENSE.txt
index 5b76d999..6486066a 100644
--- a/dist/js/ideogram.min.js.LICENSE.txt
+++ b/dist/js/ideogram.min.js.LICENSE.txt
@@ -1 +1 @@
-/*! Ideogram.js, version 1.40.0.  Developed by Eric Weitz.  https://github.com/eweitz/ideogram.  Public domain (CC0 1.0). */
+/*! Ideogram.js, version 1.41.0.  Developed by Eric Weitz.  https://github.com/eweitz/ideogram.  Public domain (CC0 1.0). */
diff --git a/dist/js/ideogram.min.js.map b/dist/js/ideogram.min.js.map
index 2da05c5e..3b60b86b 100644
--- a/dist/js/ideogram.min.js.map
+++ b/dist/js/ideogram.min.js.map
@@ -1 +1 @@
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Selection(this._enter || this._groups.map(sparse), this._parents);\n}\n\nexport function EnterNode(parent, datum) {\n  this.ownerDocument = parent.ownerDocument;\n  this.namespaceURI = parent.namespaceURI;\n  this._next = null;\n  this._parent = parent;\n  this.__data__ = datum;\n}\n\nEnterNode.prototype = {\n  constructor: EnterNode,\n  appendChild: function(child) { return this._parent.insertBefore(child, this._next); },\n  insertBefore: function(child, next) { return this._parent.insertBefore(child, next); },\n  querySelector: function(selector) { return this._parent.querySelector(selector); },\n  querySelectorAll: function(selector) { return this._parent.querySelectorAll(selector); }\n};\n","export default function(x) {\n  return function() {\n    return x;\n  };\n}\n","import {Selection} from \"./index.js\";\nimport {EnterNode} from \"./enter.js\";\nimport array from \"../array.js\";\nimport constant from \"../constant.js\";\n\nfunction bindIndex(parent, group, enter, update, exit, data) {\n  var i = 0,\n      node,\n      groupLength = group.length,\n      dataLength = data.length;\n\n  // Put any non-null nodes that fit into update.\n  // Put any null nodes into enter.\n  // Put any remaining data into enter.\n  for (; i < dataLength; ++i) {\n    if (node = group[i]) {\n      node.__data__ = data[i];\n      update[i] = node;\n    } else {\n      enter[i] = new EnterNode(parent, data[i]);\n    }\n  }\n\n  // Put any non-null nodes that don’t fit into exit.\n  for (; i < groupLength; ++i) {\n    if (node = group[i]) {\n      exit[i] = node;\n    }\n  }\n}\n\nfunction bindKey(parent, group, enter, update, exit, data, key) {\n  var i,\n      node,\n      nodeByKeyValue = new Map,\n      groupLength = group.length,\n      dataLength = data.length,\n      keyValues = new Array(groupLength),\n      keyValue;\n\n  // Compute the key for each node.\n  // If multiple nodes have the same key, the duplicates are added to exit.\n  for (i = 0; i < groupLength; ++i) {\n    if (node = group[i]) {\n      keyValues[i] = keyValue = key.call(node, node.__data__, i, group) + \"\";\n      if (nodeByKeyValue.has(keyValue)) {\n        exit[i] = node;\n      } else {\n        nodeByKeyValue.set(keyValue, node);\n      }\n    }\n  }\n\n  // Compute the key for each datum.\n  // If there a node associated with this key, join and add it to update.\n  // If there is not (or the key is a duplicate), add it to enter.\n  for (i = 0; i < dataLength; ++i) {\n    keyValue = key.call(parent, data[i], i, data) + \"\";\n    if (node = nodeByKeyValue.get(keyValue)) {\n      update[i] = node;\n      node.__data__ = data[i];\n      nodeByKeyValue.delete(keyValue);\n    } else {\n      enter[i] = new EnterNode(parent, data[i]);\n    }\n  }\n\n  // Add any remaining nodes that were not bound to data to exit.\n  for (i = 0; i < groupLength; ++i) {\n    if ((node = group[i]) && (nodeByKeyValue.get(keyValues[i]) === node)) {\n      exit[i] = node;\n    }\n  }\n}\n\nfunction datum(node) {\n  return node.__data__;\n}\n\nexport default function(value, key) {\n  if (!arguments.length) return Array.from(this, datum);\n\n  var bind = key ? bindKey : bindIndex,\n      parents = this._parents,\n      groups = this._groups;\n\n  if (typeof value !== \"function\") value = constant(value);\n\n  for (var m = groups.length, update = new Array(m), enter = new Array(m), exit = new Array(m), j = 0; j < m; ++j) {\n    var parent = parents[j],\n        group = groups[j],\n        groupLength = group.length,\n        data = array(value.call(parent, parent && parent.__data__, j, parents)),\n        dataLength = data.length,\n        enterGroup = enter[j] = new Array(dataLength),\n        updateGroup = update[j] = new Array(dataLength),\n        exitGroup = exit[j] = new Array(groupLength);\n\n    bind(parent, group, enterGroup, updateGroup, exitGroup, data, key);\n\n    // Now connect the enter nodes to their following update node, such that\n    // appendChild can insert the materialized enter node before this node,\n    // rather than at the end of the parent node.\n    for (var i0 = 0, i1 = 0, previous, next; i0 < dataLength; ++i0) {\n      if (previous = enterGroup[i0]) {\n        if (i0 >= i1) i1 = i0 + 1;\n        while (!(next = updateGroup[i1]) && ++i1 < dataLength);\n        previous._next = next || null;\n      }\n    }\n  }\n\n  update = new Selection(update, parents);\n  update._enter = enter;\n  update._exit = exit;\n  return update;\n}\n","import {Selection} from \"./index.js\";\n\nexport default function(compare) {\n  if (!compare) compare = ascending;\n\n  function compareNode(a, b) {\n    return a && b ? compare(a.__data__, b.__data__) : !a - !b;\n  }\n\n  for (var groups = this._groups, m = groups.length, sortgroups = new Array(m), j = 0; j < m; ++j) {\n    for (var group = groups[j], n = group.length, sortgroup = sortgroups[j] = new Array(n), node, i = 0; i < n; ++i) {\n      if (node = group[i]) {\n        sortgroup[i] = node;\n      }\n    }\n    sortgroup.sort(compareNode);\n  }\n\n  return new Selection(sortgroups, this._parents).order();\n}\n\nfunction ascending(a, b) {\n  return a < b ? -1 : a > b ? 1 : a >= b ? 0 : NaN;\n}\n","export var xhtml = \"http://www.w3.org/1999/xhtml\";\n\nexport default {\n  svg: \"http://www.w3.org/2000/svg\",\n  xhtml: xhtml,\n  xlink: \"http://www.w3.org/1999/xlink\",\n  xml: \"http://www.w3.org/XML/1998/namespace\",\n  xmlns: \"http://www.w3.org/2000/xmlns/\"\n};\n","import namespaces from \"./namespaces.js\";\n\nexport default function(name) {\n  var prefix = name += \"\", i = prefix.indexOf(\":\");\n  if (i >= 0 && (prefix = name.slice(0, i)) !== \"xmlns\") name = name.slice(i + 1);\n  return namespaces.hasOwnProperty(prefix) ? {space: namespaces[prefix], local: name} : name; // eslint-disable-line no-prototype-builtins\n}\n","import namespace from \"../namespace.js\";\n\nfunction attrRemove(name) {\n  return function() {\n    this.removeAttribute(name);\n  };\n}\n\nfunction attrRemoveNS(fullname) {\n  return function() {\n    this.removeAttributeNS(fullname.space, fullname.local);\n  };\n}\n\nfunction attrConstant(name, value) {\n  return function() {\n    this.setAttribute(name, value);\n  };\n}\n\nfunction attrConstantNS(fullname, value) {\n  return function() {\n    this.setAttributeNS(fullname.space, fullname.local, value);\n  };\n}\n\nfunction attrFunction(name, value) {\n  return function() {\n    var v = value.apply(this, arguments);\n    if (v == null) this.removeAttribute(name);\n    else this.setAttribute(name, v);\n  };\n}\n\nfunction attrFunctionNS(fullname, value) {\n  return function() {\n    var v = value.apply(this, arguments);\n    if (v == null) this.removeAttributeNS(fullname.space, fullname.local);\n    else this.setAttributeNS(fullname.space, fullname.local, v);\n  };\n}\n\nexport default function(name, value) {\n  var fullname = namespace(name);\n\n  if (arguments.length < 2) {\n    var node = this.node();\n    return fullname.local\n        ? node.getAttributeNS(fullname.space, fullname.local)\n        : node.getAttribute(fullname);\n  }\n\n  return this.each((value == null\n      ? (fullname.local ? attrRemoveNS : attrRemove) : (typeof value === \"function\"\n      ? (fullname.local ? attrFunctionNS : attrFunction)\n      : (fullname.local ? attrConstantNS : attrConstant)))(fullname, value));\n}\n","export default function(node) {\n  return (node.ownerDocument && node.ownerDocument.defaultView) // node is a Node\n      || (node.document && node) // node is a Window\n      || node.defaultView; // node is a Document\n}\n","import defaultView from \"../window.js\";\n\nfunction styleRemove(name) {\n  return function() {\n    this.style.removeProperty(name);\n  };\n}\n\nfunction styleConstant(name, value, priority) {\n  return function() {\n    this.style.setProperty(name, value, priority);\n  };\n}\n\nfunction styleFunction(name, value, priority) {\n  return function() {\n    var v = value.apply(this, arguments);\n    if (v == null) this.style.removeProperty(name);\n    else this.style.setProperty(name, v, priority);\n  };\n}\n\nexport default function(name, value, priority) {\n  return arguments.length > 1\n      ? this.each((value == null\n            ? styleRemove : typeof value === \"function\"\n            ? styleFunction\n            : styleConstant)(name, value, priority == null ? \"\" : priority))\n      : styleValue(this.node(), name);\n}\n\nexport function styleValue(node, name) {\n  return node.style.getPropertyValue(name)\n      || defaultView(node).getComputedStyle(node, null).getPropertyValue(name);\n}\n","function propertyRemove(name) {\n  return function() {\n    delete this[name];\n  };\n}\n\nfunction propertyConstant(name, value) {\n  return function() {\n    this[name] = value;\n  };\n}\n\nfunction propertyFunction(name, value) {\n  return function() {\n    var v = value.apply(this, arguments);\n    if (v == null) delete this[name];\n    else this[name] = v;\n  };\n}\n\nexport default function(name, value) {\n  return arguments.length > 1\n      ? this.each((value == null\n          ? propertyRemove : typeof value === \"function\"\n          ? propertyFunction\n          : propertyConstant)(name, value))\n      : this.node()[name];\n}\n","function classArray(string) {\n  return string.trim().split(/^|\\s+/);\n}\n\nfunction classList(node) {\n  return node.classList || new ClassList(node);\n}\n\nfunction ClassList(node) {\n  this._node = node;\n  this._names = classArray(node.getAttribute(\"class\") || \"\");\n}\n\nClassList.prototype = {\n  add: function(name) {\n    var i = this._names.indexOf(name);\n    if (i < 0) {\n      this._names.push(name);\n      this._node.setAttribute(\"class\", this._names.join(\" \"));\n    }\n  },\n  remove: function(name) {\n    var i = this._names.indexOf(name);\n    if (i >= 0) {\n      this._names.splice(i, 1);\n      this._node.setAttribute(\"class\", this._names.join(\" \"));\n    }\n  },\n  contains: function(name) {\n    return this._names.indexOf(name) >= 0;\n  }\n};\n\nfunction classedAdd(node, names) {\n  var list = classList(node), i = -1, n = names.length;\n  while (++i < n) list.add(names[i]);\n}\n\nfunction classedRemove(node, names) {\n  var list = classList(node), i = -1, n = names.length;\n  while (++i < n) list.remove(names[i]);\n}\n\nfunction classedTrue(names) {\n  return function() {\n    classedAdd(this, names);\n  };\n}\n\nfunction classedFalse(names) {\n  return function() {\n    classedRemove(this, names);\n  };\n}\n\nfunction classedFunction(names, value) {\n  return function() {\n    (value.apply(this, arguments) ? classedAdd : classedRemove)(this, names);\n  };\n}\n\nexport default function(name, value) {\n  var names = classArray(name + \"\");\n\n  if (arguments.length < 2) {\n    var list = classList(this.node()), i = -1, n = names.length;\n    while (++i < n) if (!list.contains(names[i])) return false;\n    return true;\n  }\n\n  return this.each((typeof value === \"function\"\n      ? classedFunction : value\n      ? classedTrue\n      : classedFalse)(names, value));\n}\n","function textRemove() {\n  this.textContent = \"\";\n}\n\nfunction textConstant(value) {\n  return function() {\n    this.textContent = value;\n  };\n}\n\nfunction textFunction(value) {\n  return function() {\n    var v = value.apply(this, arguments);\n    this.textContent = v == null ? \"\" : v;\n  };\n}\n\nexport default function(value) {\n  return arguments.length\n      ? this.each(value == null\n          ? textRemove : (typeof value === \"function\"\n          ? textFunction\n          : textConstant)(value))\n      : this.node().textContent;\n}\n","function htmlRemove() {\n  this.innerHTML = \"\";\n}\n\nfunction htmlConstant(value) {\n  return function() {\n    this.innerHTML = value;\n  };\n}\n\nfunction htmlFunction(value) {\n  return function() {\n    var v = value.apply(this, arguments);\n    this.innerHTML = v == null ? \"\" : v;\n  };\n}\n\nexport default function(value) {\n  return arguments.length\n      ? this.each(value == null\n          ? htmlRemove : (typeof value === \"function\"\n          ? htmlFunction\n          : htmlConstant)(value))\n      : this.node().innerHTML;\n}\n","function raise() {\n  if (this.nextSibling) this.parentNode.appendChild(this);\n}\n\nexport default function() {\n  return this.each(raise);\n}\n","function lower() {\n  if (this.previousSibling) this.parentNode.insertBefore(this, this.parentNode.firstChild);\n}\n\nexport default function() {\n  return this.each(lower);\n}\n","import namespace from \"./namespace.js\";\nimport {xhtml} from \"./namespaces.js\";\n\nfunction creatorInherit(name) {\n  return function() {\n    var document = this.ownerDocument,\n        uri = this.namespaceURI;\n    return uri === xhtml && document.documentElement.namespaceURI === xhtml\n        ? document.createElement(name)\n        : document.createElementNS(uri, name);\n  };\n}\n\nfunction creatorFixed(fullname) {\n  return function() {\n    return this.ownerDocument.createElementNS(fullname.space, fullname.local);\n  };\n}\n\nexport default function(name) {\n  var fullname = namespace(name);\n  return (fullname.local\n      ? creatorFixed\n      : creatorInherit)(fullname);\n}\n","import creator from \"../creator.js\";\nimport selector from \"../selector.js\";\n\nfunction constantNull() {\n  return null;\n}\n\nexport default function(name, before) {\n  var create = typeof name === \"function\" ? name : creator(name),\n      select = before == null ? constantNull : typeof before === \"function\" ? before : selector(before);\n  return this.select(function() {\n    return this.insertBefore(create.apply(this, arguments), select.apply(this, arguments) || null);\n  });\n}\n","function remove() {\n  var parent = this.parentNode;\n  if (parent) parent.removeChild(this);\n}\n\nexport default function() {\n  return this.each(remove);\n}\n","function selection_cloneShallow() {\n  var clone = this.cloneNode(false), parent = this.parentNode;\n  return parent ? parent.insertBefore(clone, this.nextSibling) : clone;\n}\n\nfunction selection_cloneDeep() {\n  var clone = this.cloneNode(true), parent = this.parentNode;\n  return parent ? parent.insertBefore(clone, this.nextSibling) : clone;\n}\n\nexport default function(deep) {\n  return this.select(deep ? selection_cloneDeep : selection_cloneShallow);\n}\n","function contextListener(listener) {\n  return function(event) {\n    listener.call(this, event, this.__data__);\n  };\n}\n\nfunction parseTypenames(typenames) {\n  return typenames.trim().split(/^|\\s+/).map(function(t) {\n    var name = \"\", i = t.indexOf(\".\");\n    if (i >= 0) name = t.slice(i + 1), t = t.slice(0, i);\n    return {type: t, name: name};\n  });\n}\n\nfunction onRemove(typename) {\n  return function() {\n    var on = this.__on;\n    if (!on) return;\n    for (var j = 0, i = -1, m = on.length, o; j < m; ++j) {\n      if (o = on[j], (!typename.type || o.type === typename.type) && o.name === typename.name) {\n        this.removeEventListener(o.type, o.listener, o.options);\n      } else {\n        on[++i] = o;\n      }\n    }\n    if (++i) on.length = i;\n    else delete this.__on;\n  };\n}\n\nfunction onAdd(typename, value, options) {\n  return function() {\n    var on = this.__on, o, listener = contextListener(value);\n    if (on) for (var j = 0, m = on.length; j < m; ++j) {\n      if ((o = on[j]).type === typename.type && o.name === typename.name) {\n        this.removeEventListener(o.type, o.listener, o.options);\n        this.addEventListener(o.type, o.listener = listener, o.options = options);\n        o.value = value;\n        return;\n      }\n    }\n    this.addEventListener(typename.type, listener, options);\n    o = {type: typename.type, name: typename.name, value: value, listener: listener, options: options};\n    if (!on) this.__on = [o];\n    else on.push(o);\n  };\n}\n\nexport default function(typename, value, options) {\n  var typenames = parseTypenames(typename + \"\"), i, n = typenames.length, t;\n\n  if (arguments.length < 2) {\n    var on = this.node().__on;\n    if (on) for (var j = 0, m = on.length, o; j < m; ++j) {\n      for (i = 0, o = on[j]; i < n; ++i) {\n        if ((t = typenames[i]).type === o.type && t.name === o.name) {\n          return o.value;\n        }\n      }\n    }\n    return;\n  }\n\n  on = value ? onAdd : onRemove;\n  for (i = 0; i < n; ++i) this.each(on(typenames[i], value, options));\n  return this;\n}\n","import defaultView from \"../window.js\";\n\nfunction dispatchEvent(node, type, params) {\n  var window = defaultView(node),\n      event = window.CustomEvent;\n\n  if (typeof event === \"function\") {\n    event = new event(type, params);\n  } else {\n    event = window.document.createEvent(\"Event\");\n    if (params) event.initEvent(type, params.bubbles, params.cancelable), event.detail = params.detail;\n    else event.initEvent(type, false, false);\n  }\n\n  node.dispatchEvent(event);\n}\n\nfunction dispatchConstant(type, params) {\n  return function() {\n    return dispatchEvent(this, type, params);\n  };\n}\n\nfunction dispatchFunction(type, params) {\n  return function() {\n    return dispatchEvent(this, type, params.apply(this, arguments));\n  };\n}\n\nexport default function(type, params) {\n  return this.each((typeof params === \"function\"\n      ? dispatchFunction\n      : dispatchConstant)(type, params));\n}\n","import selection_select from \"./select.js\";\nimport selection_selectAll from \"./selectAll.js\";\nimport selection_selectChild from \"./selectChild.js\";\nimport selection_selectChildren from \"./selectChildren.js\";\nimport selection_filter from \"./filter.js\";\nimport selection_data from \"./data.js\";\nimport selection_enter from \"./enter.js\";\nimport selection_exit from \"./exit.js\";\nimport selection_join from \"./join.js\";\nimport selection_merge from \"./merge.js\";\nimport selection_order from \"./order.js\";\nimport selection_sort from \"./sort.js\";\nimport selection_call from \"./call.js\";\nimport selection_nodes from \"./nodes.js\";\nimport selection_node from \"./node.js\";\nimport selection_size from \"./size.js\";\nimport selection_empty from \"./empty.js\";\nimport selection_each from \"./each.js\";\nimport selection_attr from \"./attr.js\";\nimport selection_style from \"./style.js\";\nimport selection_property from \"./property.js\";\nimport selection_classed from \"./classed.js\";\nimport selection_text from \"./text.js\";\nimport selection_html from \"./html.js\";\nimport selection_raise from \"./raise.js\";\nimport selection_lower from \"./lower.js\";\nimport selection_append from \"./append.js\";\nimport selection_insert from \"./insert.js\";\nimport selection_remove from \"./remove.js\";\nimport selection_clone from \"./clone.js\";\nimport selection_datum from \"./datum.js\";\nimport selection_on from \"./on.js\";\nimport selection_dispatch from \"./dispatch.js\";\nimport selection_iterator from \"./iterator.js\";\n\nexport var root = [null];\n\nexport function Selection(groups, parents) {\n  this._groups = groups;\n  this._parents = parents;\n}\n\nfunction selection() {\n  return new Selection([[document.documentElement]], root);\n}\n\nfunction selection_selection() {\n  return this;\n}\n\nSelection.prototype = selection.prototype = {\n  constructor: Selection,\n  select: selection_select,\n  selectAll: selection_selectAll,\n  selectChild: selection_selectChild,\n  selectChildren: selection_selectChildren,\n  filter: selection_filter,\n  data: selection_data,\n  enter: selection_enter,\n  exit: selection_exit,\n  join: selection_join,\n  merge: selection_merge,\n  selection: selection_selection,\n  order: selection_order,\n  sort: selection_sort,\n  call: selection_call,\n  nodes: selection_nodes,\n  node: selection_node,\n  size: selection_size,\n  empty: selection_empty,\n  each: selection_each,\n  attr: selection_attr,\n  style: selection_style,\n  property: selection_property,\n  classed: selection_classed,\n  text: selection_text,\n  html: selection_html,\n  raise: selection_raise,\n  lower: selection_lower,\n  append: selection_append,\n  insert: selection_insert,\n  remove: selection_remove,\n  clone: selection_clone,\n  datum: selection_datum,\n  on: selection_on,\n  dispatch: selection_dispatch,\n  [Symbol.iterator]: selection_iterator\n};\n\nexport default selection;\n","import {Selection} from \"./index.js\";\nimport selector from \"../selector.js\";\n\nexport default function(select) {\n  if (typeof select !== \"function\") select = selector(select);\n\n  for (var groups = this._groups, m = groups.length, subgroups = new Array(m), j = 0; j < m; ++j) {\n    for (var group = groups[j], n = group.length, subgroup = subgroups[j] = new Array(n), node, subnode, i = 0; i < n; ++i) {\n      if ((node = group[i]) && (subnode = select.call(node, node.__data__, i, group))) {\n        if (\"__data__\" in node) subnode.__data__ = node.__data__;\n        subgroup[i] = subnode;\n      }\n    }\n  }\n\n  return new Selection(subgroups, this._parents);\n}\n","import {Selection} from \"./index.js\";\nimport array from \"../array.js\";\nimport selectorAll from \"../selectorAll.js\";\n\nfunction arrayAll(select) {\n  return function() {\n    var group = select.apply(this, arguments);\n    return group == null ? [] : array(group);\n  };\n}\n\nexport default function(select) {\n  if (typeof select === \"function\") select = arrayAll(select);\n  else select = selectorAll(select);\n\n  for (var groups = this._groups, m = groups.length, subgroups = [], parents = [], j = 0; j < m; ++j) {\n    for (var group = groups[j], n = group.length, node, i = 0; i < n; ++i) {\n      if (node = group[i]) {\n        subgroups.push(select.call(node, node.__data__, i, group));\n        parents.push(node);\n      }\n    }\n  }\n\n  return new Selection(subgroups, parents);\n}\n","import {Selection} from \"./index.js\";\nimport matcher from \"../matcher.js\";\n\nexport default function(match) {\n  if (typeof match !== \"function\") match = matcher(match);\n\n  for (var groups = this._groups, m = groups.length, subgroups = new Array(m), j = 0; j < m; ++j) {\n    for (var group = groups[j], n = group.length, subgroup = subgroups[j] = [], node, i = 0; i < n; ++i) {\n      if ((node = group[i]) && match.call(node, node.__data__, i, group)) {\n        subgroup.push(node);\n      }\n    }\n  }\n\n  return new Selection(subgroups, this._parents);\n}\n","import sparse from \"./sparse.js\";\nimport {Selection} from \"./index.js\";\n\nexport default function() {\n  return new Selection(this._exit || this._groups.map(sparse), this._parents);\n}\n","export default function(onenter, onupdate, onexit) {\n  var enter = this.enter(), update = this, exit = this.exit();\n  enter = typeof onenter === \"function\" ? onenter(enter) : enter.append(onenter + \"\");\n  if (onupdate != null) update = onupdate(update);\n  if (onexit == null) exit.remove(); else onexit(exit);\n  return enter && update ? enter.merge(update).order() : update;\n}\n","import {Selection} from \"./index.js\";\n\nexport default function(selection) {\n  if (!(selection instanceof Selection)) throw new Error(\"invalid merge\");\n\n  for (var groups0 = this._groups, groups1 = selection._groups, m0 = groups0.length, m1 = groups1.length, m = Math.min(m0, m1), merges = new Array(m0), j = 0; j < m; ++j) {\n    for (var group0 = groups0[j], group1 = groups1[j], n = group0.length, merge = merges[j] = new Array(n), node, i = 0; i < n; ++i) {\n      if (node = group0[i] || group1[i]) {\n        merge[i] = node;\n      }\n    }\n  }\n\n  for (; j < m0; ++j) {\n    merges[j] = groups0[j];\n  }\n\n  return new Selection(merges, this._parents);\n}\n","export default function() {\n\n  for (var groups = this._groups, j = -1, m = groups.length; ++j < m;) {\n    for (var group = groups[j], i = group.length - 1, next = group[i], node; --i >= 0;) {\n      if (node = group[i]) {\n        if (next && node.compareDocumentPosition(next) ^ 4) next.parentNode.insertBefore(node, next);\n        next = node;\n      }\n    }\n  }\n\n  return this;\n}\n","export default function() {\n  var callback = arguments[0];\n  arguments[0] = this;\n  callback.apply(null, arguments);\n  return this;\n}\n","export default function() {\n  return Array.from(this);\n}\n","export default function() {\n\n  for (var groups = this._groups, j = 0, m = groups.length; j < m; ++j) {\n    for (var group = groups[j], i = 0, n = group.length; i < n; ++i) {\n      var node = group[i];\n      if (node) return node;\n    }\n  }\n\n  return null;\n}\n","export default function() {\n  let size = 0;\n  for (const node of this) ++size; // eslint-disable-line no-unused-vars\n  return size;\n}\n","export default function() {\n  return !this.node();\n}\n","export default function(callback) {\n\n  for (var groups = this._groups, j = 0, m = groups.length; j < m; ++j) {\n    for (var group = groups[j], i = 0, n = group.length, node; i < n; ++i) {\n      if (node = group[i]) callback.call(node, node.__data__, i, group);\n    }\n  }\n\n  return this;\n}\n","import creator from \"../creator.js\";\n\nexport default function(name) {\n  var create = typeof name === \"function\" ? name : creator(name);\n  return this.select(function() {\n    return this.appendChild(create.apply(this, arguments));\n  });\n}\n","export default function(value) {\n  return arguments.length\n      ? this.property(\"__data__\", value)\n      : this.node().__data__;\n}\n","export default function*() {\n  for (var groups = this._groups, j = 0, m = groups.length; j < m; ++j) {\n    for (var group = groups[j], i = 0, n = group.length, node; i < n; ++i) {\n      if (node = group[i]) yield node;\n    }\n  }\n}\n","import {Selection, root} from \"./selection/index.js\";\n\nexport default function(selector) {\n  return typeof selector === \"string\"\n      ? new Selection([[document.querySelector(selector)]], [document.documentElement])\n      : new Selection([[selector]], root);\n}\n","function responseBlob(response) {\n  if (!response.ok) throw new Error(response.status + \" \" + response.statusText);\n  return response.blob();\n}\n\nexport default function(input, init) {\n  return fetch(input, init).then(responseBlob);\n}\n","function responseArrayBuffer(response) {\n  if (!response.ok) throw new Error(response.status + \" \" + response.statusText);\n  return response.arrayBuffer();\n}\n\nexport default function(input, init) {\n  return fetch(input, init).then(responseArrayBuffer);\n}\n","var EOL = {},\n    EOF = {},\n    QUOTE = 34,\n    NEWLINE = 10,\n    RETURN = 13;\n\nfunction objectConverter(columns) {\n  return new Function(\"d\", \"return {\" + columns.map(function(name, i) {\n    return JSON.stringify(name) + \": d[\" + i + \"] || \\\"\\\"\";\n  }).join(\",\") + \"}\");\n}\n\nfunction customConverter(columns, f) {\n  var object = objectConverter(columns);\n  return function(row, i) {\n    return f(object(row), i, columns);\n  };\n}\n\n// Compute unique columns in order of discovery.\nfunction inferColumns(rows) {\n  var columnSet = Object.create(null),\n      columns = [];\n\n  rows.forEach(function(row) {\n    for (var column in row) {\n      if (!(column in columnSet)) {\n        columns.push(columnSet[column] = column);\n      }\n    }\n  });\n\n  return columns;\n}\n\nfunction pad(value, width) {\n  var s = value + \"\", length = s.length;\n  return length < width ? new Array(width - length + 1).join(0) + s : s;\n}\n\nfunction formatYear(year) {\n  return year < 0 ? \"-\" + pad(-year, 6)\n    : year > 9999 ? \"+\" + pad(year, 6)\n    : pad(year, 4);\n}\n\nfunction formatDate(date) {\n  var hours = date.getUTCHours(),\n      minutes = date.getUTCMinutes(),\n      seconds = date.getUTCSeconds(),\n      milliseconds = date.getUTCMilliseconds();\n  return isNaN(date) ? \"Invalid Date\"\n      : formatYear(date.getUTCFullYear(), 4) + \"-\" + pad(date.getUTCMonth() + 1, 2) + \"-\" + pad(date.getUTCDate(), 2)\n      + (milliseconds ? \"T\" + pad(hours, 2) + \":\" + pad(minutes, 2) + \":\" + pad(seconds, 2) + \".\" + pad(milliseconds, 3) + \"Z\"\n      : seconds ? \"T\" + pad(hours, 2) + \":\" + pad(minutes, 2) + \":\" + pad(seconds, 2) + \"Z\"\n      : minutes || hours ? \"T\" + pad(hours, 2) + \":\" + pad(minutes, 2) + \"Z\"\n      : \"\");\n}\n\nexport default function(delimiter) {\n  var reFormat = new RegExp(\"[\\\"\" + delimiter + \"\\n\\r]\"),\n      DELIMITER = delimiter.charCodeAt(0);\n\n  function parse(text, f) {\n    var convert, columns, rows = parseRows(text, function(row, i) {\n      if (convert) return convert(row, i - 1);\n      columns = row, convert = f ? customConverter(row, f) : objectConverter(row);\n    });\n    rows.columns = columns || [];\n    return rows;\n  }\n\n  function parseRows(text, f) {\n    var rows = [], // output rows\n        N = text.length,\n        I = 0, // current character index\n        n = 0, // current line number\n        t, // current token\n        eof = N <= 0, // current token followed by EOF?\n        eol = false; // current token followed by EOL?\n\n    // Strip the trailing newline.\n    if (text.charCodeAt(N - 1) === NEWLINE) --N;\n    if (text.charCodeAt(N - 1) === RETURN) --N;\n\n    function token() {\n      if (eof) return EOF;\n      if (eol) return eol = false, EOL;\n\n      // Unescape quotes.\n      var i, j = I, c;\n      if (text.charCodeAt(j) === QUOTE) {\n        while (I++ < N && text.charCodeAt(I) !== QUOTE || text.charCodeAt(++I) === QUOTE);\n        if ((i = I) >= N) eof = true;\n        else if ((c = text.charCodeAt(I++)) === NEWLINE) eol = true;\n        else if (c === RETURN) { eol = true; if (text.charCodeAt(I) === NEWLINE) ++I; }\n        return text.slice(j + 1, i - 1).replace(/\"\"/g, \"\\\"\");\n      }\n\n      // Find next delimiter or newline.\n      while (I < N) {\n        if ((c = text.charCodeAt(i = I++)) === NEWLINE) eol = true;\n        else if (c === RETURN) { eol = true; if (text.charCodeAt(I) === NEWLINE) ++I; }\n        else if (c !== DELIMITER) continue;\n        return text.slice(j, i);\n      }\n\n      // Return last token before EOF.\n      return eof = true, text.slice(j, N);\n    }\n\n    while ((t = token()) !== EOF) {\n      var row = [];\n      while (t !== EOL && t !== EOF) row.push(t), t = token();\n      if (f && (row = f(row, n++)) == null) continue;\n      rows.push(row);\n    }\n\n    return rows;\n  }\n\n  function preformatBody(rows, columns) {\n    return rows.map(function(row) {\n      return columns.map(function(column) {\n        return formatValue(row[column]);\n      }).join(delimiter);\n    });\n  }\n\n  function format(rows, columns) {\n    if (columns == null) columns = inferColumns(rows);\n    return [columns.map(formatValue).join(delimiter)].concat(preformatBody(rows, columns)).join(\"\\n\");\n  }\n\n  function formatBody(rows, columns) {\n    if (columns == null) columns = inferColumns(rows);\n    return preformatBody(rows, columns).join(\"\\n\");\n  }\n\n  function formatRows(rows) {\n    return rows.map(formatRow).join(\"\\n\");\n  }\n\n  function formatRow(row) {\n    return row.map(formatValue).join(delimiter);\n  }\n\n  function formatValue(value) {\n    return value == null ? \"\"\n        : value instanceof Date ? formatDate(value)\n        : reFormat.test(value += \"\") ? \"\\\"\" + value.replace(/\"/g, \"\\\"\\\"\") + \"\\\"\"\n        : value;\n  }\n\n  return {\n    parse: parse,\n    parseRows: parseRows,\n    format: format,\n    formatBody: formatBody,\n    formatRows: formatRows,\n    formatRow: formatRow,\n    formatValue: formatValue\n  };\n}\n","import dsv from \"./dsv.js\";\n\nvar csv = dsv(\",\");\n\nexport var csvParse = csv.parse;\nexport var csvParseRows = csv.parseRows;\nexport var csvFormat = csv.format;\nexport var csvFormatBody = csv.formatBody;\nexport var csvFormatRows = csv.formatRows;\nexport var csvFormatRow = csv.formatRow;\nexport var csvFormatValue = csv.formatValue;\n","import dsv from \"./dsv.js\";\n\nvar tsv = dsv(\"\\t\");\n\nexport var tsvParse = tsv.parse;\nexport var tsvParseRows = tsv.parseRows;\nexport var tsvFormat = tsv.format;\nexport var tsvFormatBody = tsv.formatBody;\nexport var tsvFormatRows = tsv.formatRows;\nexport var tsvFormatRow = tsv.formatRow;\nexport var tsvFormatValue = tsv.formatValue;\n","function responseText(response) {\n  if (!response.ok) throw new Error(response.status + \" \" + response.statusText);\n  return response.text();\n}\n\nexport default function(input, init) {\n  return fetch(input, init).then(responseText);\n}\n","import {csvParse, dsvFormat, tsvParse} from \"d3-dsv\";\nimport text from \"./text.js\";\n\nfunction dsvParse(parse) {\n  return function(input, init, row) {\n    if (arguments.length === 2 && typeof init === \"function\") row = init, init = undefined;\n    return text(input, init).then(function(response) {\n      return parse(response, row);\n    });\n  };\n}\n\nexport default function dsv(delimiter, input, init, row) {\n  if (arguments.length === 3 && typeof init === \"function\") row = init, init = undefined;\n  var format = dsvFormat(delimiter);\n  return text(input, init).then(function(response) {\n    return format.parse(response, row);\n  });\n}\n\nexport var csv = dsvParse(csvParse);\nexport var tsv = dsvParse(tsvParse);\n","export default function(input, init) {\n  return new Promise(function(resolve, reject) {\n    var image = new Image;\n    for (var key in init) image[key] = init[key];\n    image.onerror = reject;\n    image.onload = function() { resolve(image); };\n    image.src = input;\n  });\n}\n","function responseJson(response) {\n  if (!response.ok) throw new Error(response.status + \" \" + response.statusText);\n  if (response.status === 204 || response.status === 205) return;\n  return response.json();\n}\n\nexport default function(input, init) {\n  return fetch(input, init).then(responseJson);\n}\n","import text from \"./text.js\";\n\nfunction parser(type) {\n  return (input, init) => text(input, init)\n    .then(text => (new DOMParser).parseFromString(text, type));\n}\n\nexport default parser(\"application/xml\");\n\nexport var html = parser(\"text/html\");\n\nexport var svg = parser(\"image/svg+xml\");\n","var noop = {value: () => {}};\n\nfunction dispatch() {\n  for (var i = 0, n = arguments.length, _ = {}, t; i < n; ++i) {\n    if (!(t = arguments[i] + \"\") || (t in _) || /[\\s.]/.test(t)) throw new Error(\"illegal type: \" + t);\n    _[t] = [];\n  }\n  return new Dispatch(_);\n}\n\nfunction Dispatch(_) {\n  this._ = _;\n}\n\nfunction parseTypenames(typenames, types) {\n  return typenames.trim().split(/^|\\s+/).map(function(t) {\n    var name = \"\", i = t.indexOf(\".\");\n    if (i >= 0) name = t.slice(i + 1), t = t.slice(0, i);\n    if (t && !types.hasOwnProperty(t)) throw new Error(\"unknown type: \" + t);\n    return {type: t, name: name};\n  });\n}\n\nDispatch.prototype = dispatch.prototype = {\n  constructor: Dispatch,\n  on: function(typename, callback) {\n    var _ = this._,\n        T = parseTypenames(typename + \"\", _),\n        t,\n        i = -1,\n        n = T.length;\n\n    // If no callback was specified, return the callback of the given type and name.\n    if (arguments.length < 2) {\n      while (++i < n) if ((t = (typename = T[i]).type) && (t = get(_[t], typename.name))) return t;\n      return;\n    }\n\n    // If a type was specified, set the callback for the given type and name.\n    // Otherwise, if a null callback was specified, remove callbacks of the given name.\n    if (callback != null && typeof callback !== \"function\") throw new Error(\"invalid callback: \" + callback);\n    while (++i < n) {\n      if (t = (typename = T[i]).type) _[t] = set(_[t], typename.name, callback);\n      else if (callback == null) for (t in _) _[t] = set(_[t], typename.name, null);\n    }\n\n    return this;\n  },\n  copy: function() {\n    var copy = {}, _ = this._;\n    for (var t in _) copy[t] = _[t].slice();\n    return new Dispatch(copy);\n  },\n  call: function(type, that) {\n    if ((n = arguments.length - 2) > 0) for (var args = new Array(n), i = 0, n, t; i < n; ++i) args[i] = arguments[i + 2];\n    if (!this._.hasOwnProperty(type)) throw new Error(\"unknown type: \" + type);\n    for (t = this._[type], i = 0, n = t.length; i < n; ++i) t[i].value.apply(that, args);\n  },\n  apply: function(type, that, args) {\n    if (!this._.hasOwnProperty(type)) throw new Error(\"unknown type: \" + type);\n    for (var t = this._[type], i = 0, n = t.length; i < n; ++i) t[i].value.apply(that, args);\n  }\n};\n\nfunction get(type, name) {\n  for (var i = 0, n = type.length, c; i < n; ++i) {\n    if ((c = type[i]).name === name) {\n      return c.value;\n    }\n  }\n}\n\nfunction set(type, name, callback) {\n  for (var i = 0, n = type.length; i < n; ++i) {\n    if (type[i].name === name) {\n      type[i] = noop, type = type.slice(0, i).concat(type.slice(i + 1));\n      break;\n    }\n  }\n  if (callback != null) type.push({name: name, value: callback});\n  return type;\n}\n\nexport default dispatch;\n","export function nopropagation(event) {\n  event.stopImmediatePropagation();\n}\n\nexport default function(event) {\n  event.preventDefault();\n  event.stopImmediatePropagation();\n}\n","import {select} from \"d3-selection\";\nimport noevent from \"./noevent.js\";\n\nexport default function(view) {\n  var root = view.document.documentElement,\n      selection = select(view).on(\"dragstart.drag\", noevent, true);\n  if (\"onselectstart\" in root) {\n    selection.on(\"selectstart.drag\", noevent, true);\n  } else {\n    root.__noselect = root.style.MozUserSelect;\n    root.style.MozUserSelect = \"none\";\n  }\n}\n\nexport function yesdrag(view, noclick) {\n  var root = view.document.documentElement,\n      selection = select(view).on(\"dragstart.drag\", null);\n  if (noclick) {\n    selection.on(\"click.drag\", noevent, true);\n    setTimeout(function() { selection.on(\"click.drag\", null); }, 0);\n  }\n  if (\"onselectstart\" in root) {\n    selection.on(\"selectstart.drag\", null);\n  } else {\n    root.style.MozUserSelect = root.__noselect;\n    delete root.__noselect;\n  }\n}\n","export default function(constructor, factory, prototype) {\n  constructor.prototype = factory.prototype = prototype;\n  prototype.constructor = constructor;\n}\n\nexport function extend(parent, definition) {\n  var prototype = Object.create(parent.prototype);\n  for (var key in definition) prototype[key] = definition[key];\n  return prototype;\n}\n","import define, {extend} from \"./define.js\";\n\nexport function Color() {}\n\nexport var darker = 0.7;\nexport var brighter = 1 / darker;\n\nvar reI = \"\\\\s*([+-]?\\\\d+)\\\\s*\",\n    reN = \"\\\\s*([+-]?(?:\\\\d*\\\\.)?\\\\d+(?:[eE][+-]?\\\\d+)?)\\\\s*\",\n    reP = \"\\\\s*([+-]?(?:\\\\d*\\\\.)?\\\\d+(?:[eE][+-]?\\\\d+)?)%\\\\s*\",\n    reHex = /^#([0-9a-f]{3,8})$/,\n    reRgbInteger = new RegExp(`^rgb\\\\(${reI},${reI},${reI}\\\\)$`),\n    reRgbPercent = new RegExp(`^rgb\\\\(${reP},${reP},${reP}\\\\)$`),\n    reRgbaInteger = new RegExp(`^rgba\\\\(${reI},${reI},${reI},${reN}\\\\)$`),\n    reRgbaPercent = new RegExp(`^rgba\\\\(${reP},${reP},${reP},${reN}\\\\)$`),\n    reHslPercent = new RegExp(`^hsl\\\\(${reN},${reP},${reP}\\\\)$`),\n    reHslaPercent = new RegExp(`^hsla\\\\(${reN},${reP},${reP},${reN}\\\\)$`);\n\nvar named = {\n  aliceblue: 0xf0f8ff,\n  antiquewhite: 0xfaebd7,\n  aqua: 0x00ffff,\n  aquamarine: 0x7fffd4,\n  azure: 0xf0ffff,\n  beige: 0xf5f5dc,\n  bisque: 0xffe4c4,\n  black: 0x000000,\n  blanchedalmond: 0xffebcd,\n  blue: 0x0000ff,\n  blueviolet: 0x8a2be2,\n  brown: 0xa52a2a,\n  burlywood: 0xdeb887,\n  cadetblue: 0x5f9ea0,\n  chartreuse: 0x7fff00,\n  chocolate: 0xd2691e,\n  coral: 0xff7f50,\n  cornflowerblue: 0x6495ed,\n  cornsilk: 0xfff8dc,\n  crimson: 0xdc143c,\n  cyan: 0x00ffff,\n  darkblue: 0x00008b,\n  darkcyan: 0x008b8b,\n  darkgoldenrod: 0xb8860b,\n  darkgray: 0xa9a9a9,\n  darkgreen: 0x006400,\n  darkgrey: 0xa9a9a9,\n  darkkhaki: 0xbdb76b,\n  darkmagenta: 0x8b008b,\n  darkolivegreen: 0x556b2f,\n  darkorange: 0xff8c00,\n  darkorchid: 0x9932cc,\n  darkred: 0x8b0000,\n  darksalmon: 0xe9967a,\n  darkseagreen: 0x8fbc8f,\n  darkslateblue: 0x483d8b,\n  darkslategray: 0x2f4f4f,\n  darkslategrey: 0x2f4f4f,\n  darkturquoise: 0x00ced1,\n  darkviolet: 0x9400d3,\n  deeppink: 0xff1493,\n  deepskyblue: 0x00bfff,\n  dimgray: 0x696969,\n  dimgrey: 0x696969,\n  dodgerblue: 0x1e90ff,\n  firebrick: 0xb22222,\n  floralwhite: 0xfffaf0,\n  forestgreen: 0x228b22,\n  fuchsia: 0xff00ff,\n  gainsboro: 0xdcdcdc,\n  ghostwhite: 0xf8f8ff,\n  gold: 0xffd700,\n  goldenrod: 0xdaa520,\n  gray: 0x808080,\n  green: 0x008000,\n  greenyellow: 0xadff2f,\n  grey: 0x808080,\n  honeydew: 0xf0fff0,\n  hotpink: 0xff69b4,\n  indianred: 0xcd5c5c,\n  indigo: 0x4b0082,\n  ivory: 0xfffff0,\n  khaki: 0xf0e68c,\n  lavender: 0xe6e6fa,\n  lavenderblush: 0xfff0f5,\n  lawngreen: 0x7cfc00,\n  lemonchiffon: 0xfffacd,\n  lightblue: 0xadd8e6,\n  lightcoral: 0xf08080,\n  lightcyan: 0xe0ffff,\n  lightgoldenrodyellow: 0xfafad2,\n  lightgray: 0xd3d3d3,\n  lightgreen: 0x90ee90,\n  lightgrey: 0xd3d3d3,\n  lightpink: 0xffb6c1,\n  lightsalmon: 0xffa07a,\n  lightseagreen: 0x20b2aa,\n  lightskyblue: 0x87cefa,\n  lightslategray: 0x778899,\n  lightslategrey: 0x778899,\n  lightsteelblue: 0xb0c4de,\n  lightyellow: 0xffffe0,\n  lime: 0x00ff00,\n  limegreen: 0x32cd32,\n  linen: 0xfaf0e6,\n  magenta: 0xff00ff,\n  maroon: 0x800000,\n  mediumaquamarine: 0x66cdaa,\n  mediumblue: 0x0000cd,\n  mediumorchid: 0xba55d3,\n  mediumpurple: 0x9370db,\n  mediumseagreen: 0x3cb371,\n  mediumslateblue: 0x7b68ee,\n  mediumspringgreen: 0x00fa9a,\n  mediumturquoise: 0x48d1cc,\n  mediumvioletred: 0xc71585,\n  midnightblue: 0x191970,\n  mintcream: 0xf5fffa,\n  mistyrose: 0xffe4e1,\n  moccasin: 0xffe4b5,\n  navajowhite: 0xffdead,\n  navy: 0x000080,\n  oldlace: 0xfdf5e6,\n  olive: 0x808000,\n  olivedrab: 0x6b8e23,\n  orange: 0xffa500,\n  orangered: 0xff4500,\n  orchid: 0xda70d6,\n  palegoldenrod: 0xeee8aa,\n  palegreen: 0x98fb98,\n  paleturquoise: 0xafeeee,\n  palevioletred: 0xdb7093,\n  papayawhip: 0xffefd5,\n  peachpuff: 0xffdab9,\n  peru: 0xcd853f,\n  pink: 0xffc0cb,\n  plum: 0xdda0dd,\n  powderblue: 0xb0e0e6,\n  purple: 0x800080,\n  rebeccapurple: 0x663399,\n  red: 0xff0000,\n  rosybrown: 0xbc8f8f,\n  royalblue: 0x4169e1,\n  saddlebrown: 0x8b4513,\n  salmon: 0xfa8072,\n  sandybrown: 0xf4a460,\n  seagreen: 0x2e8b57,\n  seashell: 0xfff5ee,\n  sienna: 0xa0522d,\n  silver: 0xc0c0c0,\n  skyblue: 0x87ceeb,\n  slateblue: 0x6a5acd,\n  slategray: 0x708090,\n  slategrey: 0x708090,\n  snow: 0xfffafa,\n  springgreen: 0x00ff7f,\n  steelblue: 0x4682b4,\n  tan: 0xd2b48c,\n  teal: 0x008080,\n  thistle: 0xd8bfd8,\n  tomato: 0xff6347,\n  turquoise: 0x40e0d0,\n  violet: 0xee82ee,\n  wheat: 0xf5deb3,\n  white: 0xffffff,\n  whitesmoke: 0xf5f5f5,\n  yellow: 0xffff00,\n  yellowgreen: 0x9acd32\n};\n\ndefine(Color, color, {\n  copy(channels) {\n    return Object.assign(new this.constructor, this, channels);\n  },\n  displayable() {\n    return this.rgb().displayable();\n  },\n  hex: color_formatHex, // Deprecated! Use color.formatHex.\n  formatHex: color_formatHex,\n  formatHex8: color_formatHex8,\n  formatHsl: color_formatHsl,\n  formatRgb: color_formatRgb,\n  toString: color_formatRgb\n});\n\nfunction color_formatHex() {\n  return this.rgb().formatHex();\n}\n\nfunction color_formatHex8() {\n  return this.rgb().formatHex8();\n}\n\nfunction color_formatHsl() {\n  return hslConvert(this).formatHsl();\n}\n\nfunction color_formatRgb() {\n  return this.rgb().formatRgb();\n}\n\nexport default function color(format) {\n  var m, l;\n  format = (format + \"\").trim().toLowerCase();\n  return (m = reHex.exec(format)) ? (l = m[1].length, m = parseInt(m[1], 16), l === 6 ? rgbn(m) // #ff0000\n      : l === 3 ? new Rgb((m >> 8 & 0xf) | (m >> 4 & 0xf0), (m >> 4 & 0xf) | (m & 0xf0), ((m & 0xf) << 4) | (m & 0xf), 1) // #f00\n      : l === 8 ? rgba(m >> 24 & 0xff, m >> 16 & 0xff, m >> 8 & 0xff, (m & 0xff) / 0xff) // #ff000000\n      : l === 4 ? rgba((m >> 12 & 0xf) | (m >> 8 & 0xf0), (m >> 8 & 0xf) | (m >> 4 & 0xf0), (m >> 4 & 0xf) | (m & 0xf0), (((m & 0xf) << 4) | (m & 0xf)) / 0xff) // #f000\n      : null) // invalid hex\n      : (m = reRgbInteger.exec(format)) ? new Rgb(m[1], m[2], m[3], 1) // rgb(255, 0, 0)\n      : (m = reRgbPercent.exec(format)) ? new Rgb(m[1] * 255 / 100, m[2] * 255 / 100, m[3] * 255 / 100, 1) // rgb(100%, 0%, 0%)\n      : (m = reRgbaInteger.exec(format)) ? rgba(m[1], m[2], m[3], m[4]) // rgba(255, 0, 0, 1)\n      : (m = reRgbaPercent.exec(format)) ? rgba(m[1] * 255 / 100, m[2] * 255 / 100, m[3] * 255 / 100, m[4]) // rgb(100%, 0%, 0%, 1)\n      : (m = reHslPercent.exec(format)) ? hsla(m[1], m[2] / 100, m[3] / 100, 1) // hsl(120, 50%, 50%)\n      : (m = reHslaPercent.exec(format)) ? hsla(m[1], m[2] / 100, m[3] / 100, m[4]) // hsla(120, 50%, 50%, 1)\n      : named.hasOwnProperty(format) ? rgbn(named[format]) // eslint-disable-line no-prototype-builtins\n      : format === \"transparent\" ? new Rgb(NaN, NaN, NaN, 0)\n      : null;\n}\n\nfunction rgbn(n) {\n  return new Rgb(n >> 16 & 0xff, n >> 8 & 0xff, n & 0xff, 1);\n}\n\nfunction rgba(r, g, b, a) {\n  if (a <= 0) r = g = b = NaN;\n  return new Rgb(r, g, b, a);\n}\n\nexport function rgbConvert(o) {\n  if (!(o instanceof Color)) o = color(o);\n  if (!o) return new Rgb;\n  o = o.rgb();\n  return new Rgb(o.r, o.g, o.b, o.opacity);\n}\n\nexport function rgb(r, g, b, opacity) {\n  return arguments.length === 1 ? rgbConvert(r) : new Rgb(r, g, b, opacity == null ? 1 : opacity);\n}\n\nexport function Rgb(r, g, b, opacity) {\n  this.r = +r;\n  this.g = +g;\n  this.b = +b;\n  this.opacity = +opacity;\n}\n\ndefine(Rgb, rgb, extend(Color, {\n  brighter(k) {\n    k = k == null ? brighter : Math.pow(brighter, k);\n    return new Rgb(this.r * k, this.g * k, this.b * k, this.opacity);\n  },\n  darker(k) {\n    k = k == null ? darker : Math.pow(darker, k);\n    return new Rgb(this.r * k, this.g * k, this.b * k, this.opacity);\n  },\n  rgb() {\n    return this;\n  },\n  clamp() {\n    return new Rgb(clampi(this.r), clampi(this.g), clampi(this.b), clampa(this.opacity));\n  },\n  displayable() {\n    return (-0.5 <= this.r && this.r < 255.5)\n        && (-0.5 <= this.g && this.g < 255.5)\n        && (-0.5 <= this.b && this.b < 255.5)\n        && (0 <= this.opacity && this.opacity <= 1);\n  },\n  hex: rgb_formatHex, // Deprecated! Use color.formatHex.\n  formatHex: rgb_formatHex,\n  formatHex8: rgb_formatHex8,\n  formatRgb: rgb_formatRgb,\n  toString: rgb_formatRgb\n}));\n\nfunction rgb_formatHex() {\n  return `#${hex(this.r)}${hex(this.g)}${hex(this.b)}`;\n}\n\nfunction rgb_formatHex8() {\n  return `#${hex(this.r)}${hex(this.g)}${hex(this.b)}${hex((isNaN(this.opacity) ? 1 : this.opacity) * 255)}`;\n}\n\nfunction rgb_formatRgb() {\n  const a = clampa(this.opacity);\n  return `${a === 1 ? \"rgb(\" : \"rgba(\"}${clampi(this.r)}, ${clampi(this.g)}, ${clampi(this.b)}${a === 1 ? \")\" : `, ${a})`}`;\n}\n\nfunction clampa(opacity) {\n  return isNaN(opacity) ? 1 : Math.max(0, Math.min(1, opacity));\n}\n\nfunction clampi(value) {\n  return Math.max(0, Math.min(255, Math.round(value) || 0));\n}\n\nfunction hex(value) {\n  value = clampi(value);\n  return (value < 16 ? \"0\" : \"\") + value.toString(16);\n}\n\nfunction hsla(h, s, l, a) {\n  if (a <= 0) h = s = l = NaN;\n  else if (l <= 0 || l >= 1) h = s = NaN;\n  else if (s <= 0) h = NaN;\n  return new Hsl(h, s, l, a);\n}\n\nexport function hslConvert(o) {\n  if (o instanceof Hsl) return new Hsl(o.h, o.s, o.l, o.opacity);\n  if (!(o instanceof Color)) o = color(o);\n  if (!o) return new Hsl;\n  if (o instanceof Hsl) return o;\n  o = o.rgb();\n  var r = o.r / 255,\n      g = o.g / 255,\n      b = o.b / 255,\n      min = Math.min(r, g, b),\n      max = Math.max(r, g, b),\n      h = NaN,\n      s = max - min,\n      l = (max + min) / 2;\n  if (s) {\n    if (r === max) h = (g - b) / s + (g < b) * 6;\n    else if (g === max) h = (b - r) / s + 2;\n    else h = (r - g) / s + 4;\n    s /= l < 0.5 ? max + min : 2 - max - min;\n    h *= 60;\n  } else {\n    s = l > 0 && l < 1 ? 0 : h;\n  }\n  return new Hsl(h, s, l, o.opacity);\n}\n\nexport function hsl(h, s, l, opacity) {\n  return arguments.length === 1 ? hslConvert(h) : new Hsl(h, s, l, opacity == null ? 1 : opacity);\n}\n\nfunction Hsl(h, s, l, opacity) {\n  this.h = +h;\n  this.s = +s;\n  this.l = +l;\n  this.opacity = +opacity;\n}\n\ndefine(Hsl, hsl, extend(Color, {\n  brighter(k) {\n    k = k == null ? brighter : Math.pow(brighter, k);\n    return new Hsl(this.h, this.s, this.l * k, this.opacity);\n  },\n  darker(k) {\n    k = k == null ? darker : Math.pow(darker, k);\n    return new Hsl(this.h, this.s, this.l * k, this.opacity);\n  },\n  rgb() {\n    var h = this.h % 360 + (this.h < 0) * 360,\n        s = isNaN(h) || isNaN(this.s) ? 0 : this.s,\n        l = this.l,\n        m2 = l + (l < 0.5 ? l : 1 - l) * s,\n        m1 = 2 * l - m2;\n    return new Rgb(\n      hsl2rgb(h >= 240 ? h - 240 : h + 120, m1, m2),\n      hsl2rgb(h, m1, m2),\n      hsl2rgb(h < 120 ? h + 240 : h - 120, m1, m2),\n      this.opacity\n    );\n  },\n  clamp() {\n    return new Hsl(clamph(this.h), clampt(this.s), clampt(this.l), clampa(this.opacity));\n  },\n  displayable() {\n    return (0 <= this.s && this.s <= 1 || isNaN(this.s))\n        && (0 <= this.l && this.l <= 1)\n        && (0 <= this.opacity && this.opacity <= 1);\n  },\n  formatHsl() {\n    const a = clampa(this.opacity);\n    return `${a === 1 ? \"hsl(\" : \"hsla(\"}${clamph(this.h)}, ${clampt(this.s) * 100}%, ${clampt(this.l) * 100}%${a === 1 ? \")\" : `, ${a})`}`;\n  }\n}));\n\nfunction clamph(value) {\n  value = (value || 0) % 360;\n  return value < 0 ? value + 360 : value;\n}\n\nfunction clampt(value) {\n  return Math.max(0, Math.min(1, value || 0));\n}\n\n/* From FvD 13.37, CSS Color Module Level 3 */\nfunction hsl2rgb(h, m1, m2) {\n  return (h < 60 ? m1 + (m2 - m1) * h / 60\n      : h < 180 ? m2\n      : h < 240 ? m1 + (m2 - m1) * (240 - h) / 60\n      : m1) * 255;\n}\n","export function basis(t1, v0, v1, v2, v3) {\n  var t2 = t1 * t1, t3 = t2 * t1;\n  return ((1 - 3 * t1 + 3 * t2 - t3) * v0\n      + (4 - 6 * t2 + 3 * t3) * v1\n      + (1 + 3 * t1 + 3 * t2 - 3 * t3) * v2\n      + t3 * v3) / 6;\n}\n\nexport default function(values) {\n  var n = values.length - 1;\n  return function(t) {\n    var i = t <= 0 ? (t = 0) : t >= 1 ? (t = 1, n - 1) : Math.floor(t * n),\n        v1 = values[i],\n        v2 = values[i + 1],\n        v0 = i > 0 ? values[i - 1] : 2 * v1 - v2,\n        v3 = i < n - 1 ? values[i + 2] : 2 * v2 - v1;\n    return basis((t - i / n) * n, v0, v1, v2, v3);\n  };\n}\n","export default x => () => x;\n","import constant from \"./constant.js\";\n\nfunction linear(a, d) {\n  return function(t) {\n    return a + t * d;\n  };\n}\n\nfunction exponential(a, b, y) {\n  return a = Math.pow(a, y), b = Math.pow(b, y) - a, y = 1 / y, function(t) {\n    return Math.pow(a + t * b, y);\n  };\n}\n\nexport function hue(a, b) {\n  var d = b - a;\n  return d ? linear(a, d > 180 || d < -180 ? d - 360 * Math.round(d / 360) : d) : constant(isNaN(a) ? b : a);\n}\n\nexport function gamma(y) {\n  return (y = +y) === 1 ? nogamma : function(a, b) {\n    return b - a ? exponential(a, b, y) : constant(isNaN(a) ? b : a);\n  };\n}\n\nexport default function nogamma(a, b) {\n  var d = b - a;\n  return d ? linear(a, d) : constant(isNaN(a) ? b : a);\n}\n","import {rgb as colorRgb} from \"d3-color\";\nimport basis from \"./basis.js\";\nimport basisClosed from \"./basisClosed.js\";\nimport nogamma, {gamma} from \"./color.js\";\n\nexport default (function rgbGamma(y) {\n  var color = gamma(y);\n\n  function rgb(start, end) {\n    var r = color((start = colorRgb(start)).r, (end = colorRgb(end)).r),\n        g = color(start.g, end.g),\n        b = color(start.b, end.b),\n        opacity = nogamma(start.opacity, end.opacity);\n    return function(t) {\n      start.r = r(t);\n      start.g = g(t);\n      start.b = b(t);\n      start.opacity = opacity(t);\n      return start + \"\";\n    };\n  }\n\n  rgb.gamma = rgbGamma;\n\n  return rgb;\n})(1);\n\nfunction rgbSpline(spline) {\n  return function(colors) {\n    var n = colors.length,\n        r = new Array(n),\n        g = new Array(n),\n        b = new Array(n),\n        i, color;\n    for (i = 0; i < n; ++i) {\n      color = colorRgb(colors[i]);\n      r[i] = color.r || 0;\n      g[i] = color.g || 0;\n      b[i] = color.b || 0;\n    }\n    r = spline(r);\n    g = spline(g);\n    b = spline(b);\n    color.opacity = 1;\n    return function(t) {\n      color.r = r(t);\n      color.g = g(t);\n      color.b = b(t);\n      return color + \"\";\n    };\n  };\n}\n\nexport var rgbBasis = rgbSpline(basis);\nexport var rgbBasisClosed = rgbSpline(basisClosed);\n","import value from \"./value.js\";\nimport numberArray, {isNumberArray} from \"./numberArray.js\";\n\nexport default function(a, b) {\n  return (isNumberArray(b) ? numberArray : genericArray)(a, b);\n}\n\nexport function genericArray(a, b) {\n  var nb = b ? b.length : 0,\n      na = a ? Math.min(nb, a.length) : 0,\n      x = new Array(na),\n      c = new Array(nb),\n      i;\n\n  for (i = 0; i < na; ++i) x[i] = value(a[i], b[i]);\n  for (; i < nb; ++i) c[i] = b[i];\n\n  return function(t) {\n    for (i = 0; i < na; ++i) c[i] = x[i](t);\n    return c;\n  };\n}\n","export default function(a, b) {\n  var d = new Date;\n  return a = +a, b = +b, function(t) {\n    return d.setTime(a * (1 - t) + b * t), d;\n  };\n}\n","export default function(a, b) {\n  return a = +a, b = +b, function(t) {\n    return a * (1 - t) + b * t;\n  };\n}\n","import value from \"./value.js\";\n\nexport default function(a, b) {\n  var i = {},\n      c = {},\n      k;\n\n  if (a === null || typeof a !== \"object\") a = {};\n  if (b === null || typeof b !== \"object\") b = {};\n\n  for (k in b) {\n    if (k in a) {\n      i[k] = value(a[k], b[k]);\n    } else {\n      c[k] = b[k];\n    }\n  }\n\n  return function(t) {\n    for (k in i) c[k] = i[k](t);\n    return c;\n  };\n}\n","import {basis} from \"./basis.js\";\n\nexport default function(values) {\n  var n = values.length;\n  return function(t) {\n    var i = Math.floor(((t %= 1) < 0 ? ++t : t) * n),\n        v0 = values[(i + n - 1) % n],\n        v1 = values[i % n],\n        v2 = values[(i + 1) % n],\n        v3 = values[(i + 2) % n];\n    return basis((t - i / n) * n, v0, v1, v2, v3);\n  };\n}\n","import number from \"./number.js\";\n\nvar reA = /[-+]?(?:\\d+\\.?\\d*|\\.?\\d+)(?:[eE][-+]?\\d+)?/g,\n    reB = new RegExp(reA.source, \"g\");\n\nfunction zero(b) {\n  return function() {\n    return b;\n  };\n}\n\nfunction one(b) {\n  return function(t) {\n    return b(t) + \"\";\n  };\n}\n\nexport default function(a, b) {\n  var bi = reA.lastIndex = reB.lastIndex = 0, // scan index for next number in b\n      am, // current match in a\n      bm, // current match in b\n      bs, // string preceding current number in b, if any\n      i = -1, // index in s\n      s = [], // string constants and placeholders\n      q = []; // number interpolators\n\n  // Coerce inputs to strings.\n  a = a + \"\", b = b + \"\";\n\n  // Interpolate pairs of numbers in a & b.\n  while ((am = reA.exec(a))\n      && (bm = reB.exec(b))) {\n    if ((bs = bm.index) > bi) { // a string precedes the next number in b\n      bs = b.slice(bi, bs);\n      if (s[i]) s[i] += bs; // coalesce with previous string\n      else s[++i] = bs;\n    }\n    if ((am = am[0]) === (bm = bm[0])) { // numbers in a & b match\n      if (s[i]) s[i] += bm; // coalesce with previous string\n      else s[++i] = bm;\n    } else { // interpolate non-matching numbers\n      s[++i] = null;\n      q.push({i: i, x: number(am, bm)});\n    }\n    bi = reB.lastIndex;\n  }\n\n  // Add remains of b.\n  if (bi < b.length) {\n    bs = b.slice(bi);\n    if (s[i]) s[i] += bs; // coalesce with previous string\n    else s[++i] = bs;\n  }\n\n  // Special optimization for only a single match.\n  // Otherwise, interpolate each of the numbers and rejoin the string.\n  return s.length < 2 ? (q[0]\n      ? one(q[0].x)\n      : zero(b))\n      : (b = q.length, function(t) {\n          for (var i = 0, o; i < b; ++i) s[(o = q[i]).i] = o.x(t);\n          return s.join(\"\");\n        });\n}\n","export default function(a, b) {\n  if (!b) b = [];\n  var n = a ? Math.min(b.length, a.length) : 0,\n      c = b.slice(),\n      i;\n  return function(t) {\n    for (i = 0; i < n; ++i) c[i] = a[i] * (1 - t) + b[i] * t;\n    return c;\n  };\n}\n\nexport function isNumberArray(x) {\n  return ArrayBuffer.isView(x) && !(x instanceof DataView);\n}\n","import {color} from \"d3-color\";\nimport rgb from \"./rgb.js\";\nimport {genericArray} from \"./array.js\";\nimport date from \"./date.js\";\nimport number from \"./number.js\";\nimport object from \"./object.js\";\nimport string from \"./string.js\";\nimport constant from \"./constant.js\";\nimport numberArray, {isNumberArray} from \"./numberArray.js\";\n\nexport default function(a, b) {\n  var t = typeof b, c;\n  return b == null || t === \"boolean\" ? constant(b)\n      : (t === \"number\" ? number\n      : t === \"string\" ? ((c = color(b)) ? (b = c, rgb) : string)\n      : b instanceof color ? rgb\n      : b instanceof Date ? date\n      : isNumberArray(b) ? numberArray\n      : Array.isArray(b) ? genericArray\n      : typeof b.valueOf !== \"function\" && typeof b.toString !== \"function\" || isNaN(b) ? object\n      : number)(a, b);\n}\n","function none() {}\n\nexport default function(selector) {\n  return selector == null ? none : function() {\n    return this.querySelector(selector);\n  };\n}\n","// Given something array like (or null), returns something that is strictly an\n// array. This is used to ensure that array-like objects passed to d3.selectAll\n// or selection.selectAll are converted into proper arrays when creating a\n// selection; we don’t ever want to create a selection backed by a live\n// HTMLCollection or NodeList. However, note that selection.selectAll will use a\n// static NodeList as a group, since it safely derived from querySelectorAll.\nexport default function array(x) {\n  return x == null ? [] : Array.isArray(x) ? x : Array.from(x);\n}\n","function empty() {\n  return [];\n}\n\nexport default function(selector) {\n  return selector == null ? empty : function() {\n    return this.querySelectorAll(selector);\n  };\n}\n","export default function(selector) {\n  return function() {\n    return this.matches(selector);\n  };\n}\n\nexport function childMatcher(selector) {\n  return function(node) {\n    return node.matches(selector);\n  };\n}\n\n","import {childMatcher} from \"../matcher.js\";\n\nvar find = Array.prototype.find;\n\nfunction childFind(match) {\n  return function() {\n    return find.call(this.children, match);\n  };\n}\n\nfunction childFirst() {\n  return this.firstElementChild;\n}\n\nexport default function(match) {\n  return this.select(match == null ? childFirst\n      : childFind(typeof match === \"function\" ? match : childMatcher(match)));\n}\n","import {childMatcher} from \"../matcher.js\";\n\nvar filter = Array.prototype.filter;\n\nfunction children() {\n  return Array.from(this.children);\n}\n\nfunction childrenFilter(match) {\n  return function() {\n    return filter.call(this.children, match);\n  };\n}\n\nexport default function(match) {\n  return this.selectAll(match == null ? children\n      : childrenFilter(typeof match === \"function\" ? match : childMatcher(match)));\n}\n","export default function(update) {\n  return new Array(update.length);\n}\n","import sparse from \"./sparse.js\";\nimport {Selection} from \"./index.js\";\n\nexport default function() {\n  return new Selection(this._enter || this._groups.map(sparse), this._parents);\n}\n\nexport function EnterNode(parent, datum) {\n  this.ownerDocument = parent.ownerDocument;\n  this.namespaceURI = parent.namespaceURI;\n  this._next = null;\n  this._parent = parent;\n  this.__data__ = datum;\n}\n\nEnterNode.prototype = {\n  constructor: EnterNode,\n  appendChild: function(child) { return this._parent.insertBefore(child, this._next); },\n  insertBefore: function(child, next) { return this._parent.insertBefore(child, next); },\n  querySelector: function(selector) { return this._parent.querySelector(selector); },\n  querySelectorAll: function(selector) { return this._parent.querySelectorAll(selector); }\n};\n","export default function(x) {\n  return function() {\n    return x;\n  };\n}\n","import {Selection} from \"./index.js\";\nimport {EnterNode} from \"./enter.js\";\nimport constant from \"../constant.js\";\n\nfunction bindIndex(parent, group, enter, update, exit, data) {\n  var i = 0,\n      node,\n      groupLength = group.length,\n      dataLength = data.length;\n\n  // Put any non-null nodes that fit into update.\n  // Put any null nodes into enter.\n  // Put any remaining data into enter.\n  for (; i < dataLength; ++i) {\n    if (node = group[i]) {\n      node.__data__ = data[i];\n      update[i] = node;\n    } else {\n      enter[i] = new EnterNode(parent, data[i]);\n    }\n  }\n\n  // Put any non-null nodes that don’t fit into exit.\n  for (; i < groupLength; ++i) {\n    if (node = group[i]) {\n      exit[i] = node;\n    }\n  }\n}\n\nfunction bindKey(parent, group, enter, update, exit, data, key) {\n  var i,\n      node,\n      nodeByKeyValue = new Map,\n      groupLength = group.length,\n      dataLength = data.length,\n      keyValues = new Array(groupLength),\n      keyValue;\n\n  // Compute the key for each node.\n  // If multiple nodes have the same key, the duplicates are added to exit.\n  for (i = 0; i < groupLength; ++i) {\n    if (node = group[i]) {\n      keyValues[i] = keyValue = key.call(node, node.__data__, i, group) + \"\";\n      if (nodeByKeyValue.has(keyValue)) {\n        exit[i] = node;\n      } else {\n        nodeByKeyValue.set(keyValue, node);\n      }\n    }\n  }\n\n  // Compute the key for each datum.\n  // If there a node associated with this key, join and add it to update.\n  // If there is not (or the key is a duplicate), add it to enter.\n  for (i = 0; i < dataLength; ++i) {\n    keyValue = key.call(parent, data[i], i, data) + \"\";\n    if (node = nodeByKeyValue.get(keyValue)) {\n      update[i] = node;\n      node.__data__ = data[i];\n      nodeByKeyValue.delete(keyValue);\n    } else {\n      enter[i] = new EnterNode(parent, data[i]);\n    }\n  }\n\n  // Add any remaining nodes that were not bound to data to exit.\n  for (i = 0; i < groupLength; ++i) {\n    if ((node = group[i]) && (nodeByKeyValue.get(keyValues[i]) === node)) {\n      exit[i] = node;\n    }\n  }\n}\n\nfunction datum(node) {\n  return node.__data__;\n}\n\nexport default function(value, key) {\n  if (!arguments.length) return Array.from(this, datum);\n\n  var bind = key ? bindKey : bindIndex,\n      parents = this._parents,\n      groups = this._groups;\n\n  if (typeof value !== \"function\") value = constant(value);\n\n  for (var m = groups.length, update = new Array(m), enter = new Array(m), exit = new Array(m), j = 0; j < m; ++j) {\n    var parent = parents[j],\n        group = groups[j],\n        groupLength = group.length,\n        data = arraylike(value.call(parent, parent && parent.__data__, j, parents)),\n        dataLength = data.length,\n        enterGroup = enter[j] = new Array(dataLength),\n        updateGroup = update[j] = new Array(dataLength),\n        exitGroup = exit[j] = new Array(groupLength);\n\n    bind(parent, group, enterGroup, updateGroup, exitGroup, data, key);\n\n    // Now connect the enter nodes to their following update node, such that\n    // appendChild can insert the materialized enter node before this node,\n    // rather than at the end of the parent node.\n    for (var i0 = 0, i1 = 0, previous, next; i0 < dataLength; ++i0) {\n      if (previous = enterGroup[i0]) {\n        if (i0 >= i1) i1 = i0 + 1;\n        while (!(next = updateGroup[i1]) && ++i1 < dataLength);\n        previous._next = next || null;\n      }\n    }\n  }\n\n  update = new Selection(update, parents);\n  update._enter = enter;\n  update._exit = exit;\n  return update;\n}\n\n// Given some data, this returns an array-like view of it: an object that\n// exposes a length property and allows numeric indexing. Note that unlike\n// selectAll, this isn’t worried about “live” collections because the resulting\n// array will only be used briefly while data is being bound. (It is possible to\n// cause the data to change while iterating by using a key function, but please\n// don’t; we’d rather avoid a gratuitous copy.)\nfunction arraylike(data) {\n  return typeof data === \"object\" && \"length\" in data\n    ? data // Array, TypedArray, NodeList, array-like\n    : Array.from(data); // Map, Set, iterable, string, or anything else\n}\n","import {Selection} from \"./index.js\";\n\nexport default function(compare) {\n  if (!compare) compare = ascending;\n\n  function compareNode(a, b) {\n    return a && b ? compare(a.__data__, b.__data__) : !a - !b;\n  }\n\n  for (var groups = this._groups, m = groups.length, sortgroups = new Array(m), j = 0; j < m; ++j) {\n    for (var group = groups[j], n = group.length, sortgroup = sortgroups[j] = new Array(n), node, i = 0; i < n; ++i) {\n      if (node = group[i]) {\n        sortgroup[i] = node;\n      }\n    }\n    sortgroup.sort(compareNode);\n  }\n\n  return new Selection(sortgroups, this._parents).order();\n}\n\nfunction ascending(a, b) {\n  return a < b ? -1 : a > b ? 1 : a >= b ? 0 : NaN;\n}\n","export var xhtml = \"http://www.w3.org/1999/xhtml\";\n\nexport default {\n  svg: \"http://www.w3.org/2000/svg\",\n  xhtml: xhtml,\n  xlink: \"http://www.w3.org/1999/xlink\",\n  xml: \"http://www.w3.org/XML/1998/namespace\",\n  xmlns: \"http://www.w3.org/2000/xmlns/\"\n};\n","import namespaces from \"./namespaces.js\";\n\nexport default function(name) {\n  var prefix = name += \"\", i = prefix.indexOf(\":\");\n  if (i >= 0 && (prefix = name.slice(0, i)) !== \"xmlns\") name = name.slice(i + 1);\n  return namespaces.hasOwnProperty(prefix) ? {space: namespaces[prefix], local: name} : name; // eslint-disable-line no-prototype-builtins\n}\n","import namespace from \"../namespace.js\";\n\nfunction attrRemove(name) {\n  return function() {\n    this.removeAttribute(name);\n  };\n}\n\nfunction attrRemoveNS(fullname) {\n  return function() {\n    this.removeAttributeNS(fullname.space, fullname.local);\n  };\n}\n\nfunction attrConstant(name, value) {\n  return function() {\n    this.setAttribute(name, value);\n  };\n}\n\nfunction attrConstantNS(fullname, value) {\n  return function() {\n    this.setAttributeNS(fullname.space, fullname.local, value);\n  };\n}\n\nfunction attrFunction(name, value) {\n  return function() {\n    var v = value.apply(this, arguments);\n    if (v == null) this.removeAttribute(name);\n    else this.setAttribute(name, v);\n  };\n}\n\nfunction attrFunctionNS(fullname, value) {\n  return function() {\n    var v = value.apply(this, arguments);\n    if (v == null) this.removeAttributeNS(fullname.space, fullname.local);\n    else this.setAttributeNS(fullname.space, fullname.local, v);\n  };\n}\n\nexport default function(name, value) {\n  var fullname = namespace(name);\n\n  if (arguments.length < 2) {\n    var node = this.node();\n    return fullname.local\n        ? node.getAttributeNS(fullname.space, fullname.local)\n        : node.getAttribute(fullname);\n  }\n\n  return this.each((value == null\n      ? (fullname.local ? attrRemoveNS : attrRemove) : (typeof value === \"function\"\n      ? (fullname.local ? attrFunctionNS : attrFunction)\n      : (fullname.local ? attrConstantNS : attrConstant)))(fullname, value));\n}\n","export default function(node) {\n  return (node.ownerDocument && node.ownerDocument.defaultView) // node is a Node\n      || (node.document && node) // node is a Window\n      || node.defaultView; // node is a Document\n}\n","import defaultView from \"../window.js\";\n\nfunction styleRemove(name) {\n  return function() {\n    this.style.removeProperty(name);\n  };\n}\n\nfunction styleConstant(name, value, priority) {\n  return function() {\n    this.style.setProperty(name, value, priority);\n  };\n}\n\nfunction styleFunction(name, value, priority) {\n  return function() {\n    var v = value.apply(this, arguments);\n    if (v == null) this.style.removeProperty(name);\n    else this.style.setProperty(name, v, priority);\n  };\n}\n\nexport default function(name, value, priority) {\n  return arguments.length > 1\n      ? this.each((value == null\n            ? styleRemove : typeof value === \"function\"\n            ? styleFunction\n            : styleConstant)(name, value, priority == null ? \"\" : priority))\n      : styleValue(this.node(), name);\n}\n\nexport function styleValue(node, name) {\n  return node.style.getPropertyValue(name)\n      || defaultView(node).getComputedStyle(node, null).getPropertyValue(name);\n}\n","function propertyRemove(name) {\n  return function() {\n    delete this[name];\n  };\n}\n\nfunction propertyConstant(name, value) {\n  return function() {\n    this[name] = value;\n  };\n}\n\nfunction propertyFunction(name, value) {\n  return function() {\n    var v = value.apply(this, arguments);\n    if (v == null) delete this[name];\n    else this[name] = v;\n  };\n}\n\nexport default function(name, value) {\n  return arguments.length > 1\n      ? this.each((value == null\n          ? propertyRemove : typeof value === \"function\"\n          ? propertyFunction\n          : propertyConstant)(name, value))\n      : this.node()[name];\n}\n","function classArray(string) {\n  return string.trim().split(/^|\\s+/);\n}\n\nfunction classList(node) {\n  return node.classList || new ClassList(node);\n}\n\nfunction ClassList(node) {\n  this._node = node;\n  this._names = classArray(node.getAttribute(\"class\") || \"\");\n}\n\nClassList.prototype = {\n  add: function(name) {\n    var i = this._names.indexOf(name);\n    if (i < 0) {\n      this._names.push(name);\n      this._node.setAttribute(\"class\", this._names.join(\" \"));\n    }\n  },\n  remove: function(name) {\n    var i = this._names.indexOf(name);\n    if (i >= 0) {\n      this._names.splice(i, 1);\n      this._node.setAttribute(\"class\", this._names.join(\" \"));\n    }\n  },\n  contains: function(name) {\n    return this._names.indexOf(name) >= 0;\n  }\n};\n\nfunction classedAdd(node, names) {\n  var list = classList(node), i = -1, n = names.length;\n  while (++i < n) list.add(names[i]);\n}\n\nfunction classedRemove(node, names) {\n  var list = classList(node), i = -1, n = names.length;\n  while (++i < n) list.remove(names[i]);\n}\n\nfunction classedTrue(names) {\n  return function() {\n    classedAdd(this, names);\n  };\n}\n\nfunction classedFalse(names) {\n  return function() {\n    classedRemove(this, names);\n  };\n}\n\nfunction classedFunction(names, value) {\n  return function() {\n    (value.apply(this, arguments) ? classedAdd : classedRemove)(this, names);\n  };\n}\n\nexport default function(name, value) {\n  var names = classArray(name + \"\");\n\n  if (arguments.length < 2) {\n    var list = classList(this.node()), i = -1, n = names.length;\n    while (++i < n) if (!list.contains(names[i])) return false;\n    return true;\n  }\n\n  return this.each((typeof value === \"function\"\n      ? classedFunction : value\n      ? classedTrue\n      : classedFalse)(names, value));\n}\n","function textRemove() {\n  this.textContent = \"\";\n}\n\nfunction textConstant(value) {\n  return function() {\n    this.textContent = value;\n  };\n}\n\nfunction textFunction(value) {\n  return function() {\n    var v = value.apply(this, arguments);\n    this.textContent = v == null ? \"\" : v;\n  };\n}\n\nexport default function(value) {\n  return arguments.length\n      ? this.each(value == null\n          ? textRemove : (typeof value === \"function\"\n          ? textFunction\n          : textConstant)(value))\n      : this.node().textContent;\n}\n","function htmlRemove() {\n  this.innerHTML = \"\";\n}\n\nfunction htmlConstant(value) {\n  return function() {\n    this.innerHTML = value;\n  };\n}\n\nfunction htmlFunction(value) {\n  return function() {\n    var v = value.apply(this, arguments);\n    this.innerHTML = v == null ? \"\" : v;\n  };\n}\n\nexport default function(value) {\n  return arguments.length\n      ? this.each(value == null\n          ? htmlRemove : (typeof value === \"function\"\n          ? htmlFunction\n          : htmlConstant)(value))\n      : this.node().innerHTML;\n}\n","function raise() {\n  if (this.nextSibling) this.parentNode.appendChild(this);\n}\n\nexport default function() {\n  return this.each(raise);\n}\n","function lower() {\n  if (this.previousSibling) this.parentNode.insertBefore(this, this.parentNode.firstChild);\n}\n\nexport default function() {\n  return this.each(lower);\n}\n","import namespace from \"./namespace.js\";\nimport {xhtml} from \"./namespaces.js\";\n\nfunction creatorInherit(name) {\n  return function() {\n    var document = this.ownerDocument,\n        uri = this.namespaceURI;\n    return uri === xhtml && document.documentElement.namespaceURI === xhtml\n        ? document.createElement(name)\n        : document.createElementNS(uri, name);\n  };\n}\n\nfunction creatorFixed(fullname) {\n  return function() {\n    return this.ownerDocument.createElementNS(fullname.space, fullname.local);\n  };\n}\n\nexport default function(name) {\n  var fullname = namespace(name);\n  return (fullname.local\n      ? creatorFixed\n      : creatorInherit)(fullname);\n}\n","import creator from \"../creator.js\";\nimport selector from \"../selector.js\";\n\nfunction constantNull() {\n  return null;\n}\n\nexport default function(name, before) {\n  var create = typeof name === \"function\" ? name : creator(name),\n      select = before == null ? constantNull : typeof before === \"function\" ? before : selector(before);\n  return this.select(function() {\n    return this.insertBefore(create.apply(this, arguments), select.apply(this, arguments) || null);\n  });\n}\n","function remove() {\n  var parent = this.parentNode;\n  if (parent) parent.removeChild(this);\n}\n\nexport default function() {\n  return this.each(remove);\n}\n","function selection_cloneShallow() {\n  var clone = this.cloneNode(false), parent = this.parentNode;\n  return parent ? parent.insertBefore(clone, this.nextSibling) : clone;\n}\n\nfunction selection_cloneDeep() {\n  var clone = this.cloneNode(true), parent = this.parentNode;\n  return parent ? parent.insertBefore(clone, this.nextSibling) : clone;\n}\n\nexport default function(deep) {\n  return this.select(deep ? selection_cloneDeep : selection_cloneShallow);\n}\n","function contextListener(listener) {\n  return function(event) {\n    listener.call(this, event, this.__data__);\n  };\n}\n\nfunction parseTypenames(typenames) {\n  return typenames.trim().split(/^|\\s+/).map(function(t) {\n    var name = \"\", i = t.indexOf(\".\");\n    if (i >= 0) name = t.slice(i + 1), t = t.slice(0, i);\n    return {type: t, name: name};\n  });\n}\n\nfunction onRemove(typename) {\n  return function() {\n    var on = this.__on;\n    if (!on) return;\n    for (var j = 0, i = -1, m = on.length, o; j < m; ++j) {\n      if (o = on[j], (!typename.type || o.type === typename.type) && o.name === typename.name) {\n        this.removeEventListener(o.type, o.listener, o.options);\n      } else {\n        on[++i] = o;\n      }\n    }\n    if (++i) on.length = i;\n    else delete this.__on;\n  };\n}\n\nfunction onAdd(typename, value, options) {\n  return function() {\n    var on = this.__on, o, listener = contextListener(value);\n    if (on) for (var j = 0, m = on.length; j < m; ++j) {\n      if ((o = on[j]).type === typename.type && o.name === typename.name) {\n        this.removeEventListener(o.type, o.listener, o.options);\n        this.addEventListener(o.type, o.listener = listener, o.options = options);\n        o.value = value;\n        return;\n      }\n    }\n    this.addEventListener(typename.type, listener, options);\n    o = {type: typename.type, name: typename.name, value: value, listener: listener, options: options};\n    if (!on) this.__on = [o];\n    else on.push(o);\n  };\n}\n\nexport default function(typename, value, options) {\n  var typenames = parseTypenames(typename + \"\"), i, n = typenames.length, t;\n\n  if (arguments.length < 2) {\n    var on = this.node().__on;\n    if (on) for (var j = 0, m = on.length, o; j < m; ++j) {\n      for (i = 0, o = on[j]; i < n; ++i) {\n        if ((t = typenames[i]).type === o.type && t.name === o.name) {\n          return o.value;\n        }\n      }\n    }\n    return;\n  }\n\n  on = value ? onAdd : onRemove;\n  for (i = 0; i < n; ++i) this.each(on(typenames[i], value, options));\n  return this;\n}\n","import defaultView from \"../window.js\";\n\nfunction dispatchEvent(node, type, params) {\n  var window = defaultView(node),\n      event = window.CustomEvent;\n\n  if (typeof event === \"function\") {\n    event = new event(type, params);\n  } else {\n    event = window.document.createEvent(\"Event\");\n    if (params) event.initEvent(type, params.bubbles, params.cancelable), event.detail = params.detail;\n    else event.initEvent(type, false, false);\n  }\n\n  node.dispatchEvent(event);\n}\n\nfunction dispatchConstant(type, params) {\n  return function() {\n    return dispatchEvent(this, type, params);\n  };\n}\n\nfunction dispatchFunction(type, params) {\n  return function() {\n    return dispatchEvent(this, type, params.apply(this, arguments));\n  };\n}\n\nexport default function(type, params) {\n  return this.each((typeof params === \"function\"\n      ? dispatchFunction\n      : dispatchConstant)(type, params));\n}\n","import selection_select from \"./select.js\";\nimport selection_selectAll from \"./selectAll.js\";\nimport selection_selectChild from \"./selectChild.js\";\nimport selection_selectChildren from \"./selectChildren.js\";\nimport selection_filter from \"./filter.js\";\nimport selection_data from \"./data.js\";\nimport selection_enter from \"./enter.js\";\nimport selection_exit from \"./exit.js\";\nimport selection_join from \"./join.js\";\nimport selection_merge from \"./merge.js\";\nimport selection_order from \"./order.js\";\nimport selection_sort from \"./sort.js\";\nimport selection_call from \"./call.js\";\nimport selection_nodes from \"./nodes.js\";\nimport selection_node from \"./node.js\";\nimport selection_size from \"./size.js\";\nimport selection_empty from \"./empty.js\";\nimport selection_each from \"./each.js\";\nimport selection_attr from \"./attr.js\";\nimport selection_style from \"./style.js\";\nimport selection_property from \"./property.js\";\nimport selection_classed from \"./classed.js\";\nimport selection_text from \"./text.js\";\nimport selection_html from \"./html.js\";\nimport selection_raise from \"./raise.js\";\nimport selection_lower from \"./lower.js\";\nimport selection_append from \"./append.js\";\nimport selection_insert from \"./insert.js\";\nimport selection_remove from \"./remove.js\";\nimport selection_clone from \"./clone.js\";\nimport selection_datum from \"./datum.js\";\nimport selection_on from \"./on.js\";\nimport selection_dispatch from \"./dispatch.js\";\nimport selection_iterator from \"./iterator.js\";\n\nexport var root = [null];\n\nexport function Selection(groups, parents) {\n  this._groups = groups;\n  this._parents = parents;\n}\n\nfunction selection() {\n  return new Selection([[document.documentElement]], root);\n}\n\nfunction selection_selection() {\n  return this;\n}\n\nSelection.prototype = selection.prototype = {\n  constructor: Selection,\n  select: selection_select,\n  selectAll: selection_selectAll,\n  selectChild: selection_selectChild,\n  selectChildren: selection_selectChildren,\n  filter: selection_filter,\n  data: selection_data,\n  enter: selection_enter,\n  exit: selection_exit,\n  join: selection_join,\n  merge: selection_merge,\n  selection: selection_selection,\n  order: selection_order,\n  sort: selection_sort,\n  call: selection_call,\n  nodes: selection_nodes,\n  node: selection_node,\n  size: selection_size,\n  empty: selection_empty,\n  each: selection_each,\n  attr: selection_attr,\n  style: selection_style,\n  property: selection_property,\n  classed: selection_classed,\n  text: selection_text,\n  html: selection_html,\n  raise: selection_raise,\n  lower: selection_lower,\n  append: selection_append,\n  insert: selection_insert,\n  remove: selection_remove,\n  clone: selection_clone,\n  datum: selection_datum,\n  on: selection_on,\n  dispatch: selection_dispatch,\n  [Symbol.iterator]: selection_iterator\n};\n\nexport default selection;\n","import {Selection, root} from \"./selection/index.js\";\n\nexport default function(selector) {\n  return typeof selector === \"string\"\n      ? new Selection([[document.querySelector(selector)]], [document.documentElement])\n      : new Selection([[selector]], root);\n}\n","import sourceEvent from \"./sourceEvent.js\";\n\nexport default function(event, node) {\n  event = sourceEvent(event);\n  if (node === undefined) node = event.currentTarget;\n  if (node) {\n    var svg = node.ownerSVGElement || node;\n    if (svg.createSVGPoint) {\n      var point = svg.createSVGPoint();\n      point.x = event.clientX, point.y = event.clientY;\n      point = point.matrixTransform(node.getScreenCTM().inverse());\n      return [point.x, point.y];\n    }\n    if (node.getBoundingClientRect) {\n      var rect = node.getBoundingClientRect();\n      return [event.clientX - rect.left - node.clientLeft, event.clientY - rect.top - node.clientTop];\n    }\n  }\n  return [event.pageX, event.pageY];\n}\n","export default function(event) {\n  let sourceEvent;\n  while (sourceEvent = event.sourceEvent) event = sourceEvent;\n  return event;\n}\n","import {Selection} from \"./index.js\";\nimport selector from \"../selector.js\";\n\nexport default function(select) {\n  if (typeof select !== \"function\") select = selector(select);\n\n  for (var groups = this._groups, m = groups.length, subgroups = new Array(m), j = 0; j < m; ++j) {\n    for (var group = groups[j], n = group.length, subgroup = subgroups[j] = new Array(n), node, subnode, i = 0; i < n; ++i) {\n      if ((node = group[i]) && (subnode = select.call(node, node.__data__, i, group))) {\n        if (\"__data__\" in node) subnode.__data__ = node.__data__;\n        subgroup[i] = subnode;\n      }\n    }\n  }\n\n  return new Selection(subgroups, this._parents);\n}\n","import {Selection} from \"./index.js\";\nimport array from \"../array.js\";\nimport selectorAll from \"../selectorAll.js\";\n\nfunction arrayAll(select) {\n  return function() {\n    return array(select.apply(this, arguments));\n  };\n}\n\nexport default function(select) {\n  if (typeof select === \"function\") select = arrayAll(select);\n  else select = selectorAll(select);\n\n  for (var groups = this._groups, m = groups.length, subgroups = [], parents = [], j = 0; j < m; ++j) {\n    for (var group = groups[j], n = group.length, node, i = 0; i < n; ++i) {\n      if (node = group[i]) {\n        subgroups.push(select.call(node, node.__data__, i, group));\n        parents.push(node);\n      }\n    }\n  }\n\n  return new Selection(subgroups, parents);\n}\n","import {Selection} from \"./index.js\";\nimport matcher from \"../matcher.js\";\n\nexport default function(match) {\n  if (typeof match !== \"function\") match = matcher(match);\n\n  for (var groups = this._groups, m = groups.length, subgroups = new Array(m), j = 0; j < m; ++j) {\n    for (var group = groups[j], n = group.length, subgroup = subgroups[j] = [], node, i = 0; i < n; ++i) {\n      if ((node = group[i]) && match.call(node, node.__data__, i, group)) {\n        subgroup.push(node);\n      }\n    }\n  }\n\n  return new Selection(subgroups, this._parents);\n}\n","import sparse from \"./sparse.js\";\nimport {Selection} from \"./index.js\";\n\nexport default function() {\n  return new Selection(this._exit || this._groups.map(sparse), this._parents);\n}\n","export default function(onenter, onupdate, onexit) {\n  var enter = this.enter(), update = this, exit = this.exit();\n  if (typeof onenter === \"function\") {\n    enter = onenter(enter);\n    if (enter) enter = enter.selection();\n  } else {\n    enter = enter.append(onenter + \"\");\n  }\n  if (onupdate != null) {\n    update = onupdate(update);\n    if (update) update = update.selection();\n  }\n  if (onexit == null) exit.remove(); else onexit(exit);\n  return enter && update ? enter.merge(update).order() : update;\n}\n","import {Selection} from \"./index.js\";\n\nexport default function(context) {\n  var selection = context.selection ? context.selection() : context;\n\n  for (var groups0 = this._groups, groups1 = selection._groups, m0 = groups0.length, m1 = groups1.length, m = Math.min(m0, m1), merges = new Array(m0), j = 0; j < m; ++j) {\n    for (var group0 = groups0[j], group1 = groups1[j], n = group0.length, merge = merges[j] = new Array(n), node, i = 0; i < n; ++i) {\n      if (node = group0[i] || group1[i]) {\n        merge[i] = node;\n      }\n    }\n  }\n\n  for (; j < m0; ++j) {\n    merges[j] = groups0[j];\n  }\n\n  return new Selection(merges, this._parents);\n}\n","export default function() {\n\n  for (var groups = this._groups, j = -1, m = groups.length; ++j < m;) {\n    for (var group = groups[j], i = group.length - 1, next = group[i], node; --i >= 0;) {\n      if (node = group[i]) {\n        if (next && node.compareDocumentPosition(next) ^ 4) next.parentNode.insertBefore(node, next);\n        next = node;\n      }\n    }\n  }\n\n  return this;\n}\n","export default function() {\n  var callback = arguments[0];\n  arguments[0] = this;\n  callback.apply(null, arguments);\n  return this;\n}\n","export default function() {\n  return Array.from(this);\n}\n","export default function() {\n\n  for (var groups = this._groups, j = 0, m = groups.length; j < m; ++j) {\n    for (var group = groups[j], i = 0, n = group.length; i < n; ++i) {\n      var node = group[i];\n      if (node) return node;\n    }\n  }\n\n  return null;\n}\n","export default function() {\n  let size = 0;\n  for (const node of this) ++size; // eslint-disable-line no-unused-vars\n  return size;\n}\n","export default function() {\n  return !this.node();\n}\n","export default function(callback) {\n\n  for (var groups = this._groups, j = 0, m = groups.length; j < m; ++j) {\n    for (var group = groups[j], i = 0, n = group.length, node; i < n; ++i) {\n      if (node = group[i]) callback.call(node, node.__data__, i, group);\n    }\n  }\n\n  return this;\n}\n","import creator from \"../creator.js\";\n\nexport default function(name) {\n  var create = typeof name === \"function\" ? name : creator(name);\n  return this.select(function() {\n    return this.appendChild(create.apply(this, arguments));\n  });\n}\n","export default function(value) {\n  return arguments.length\n      ? this.property(\"__data__\", value)\n      : this.node().__data__;\n}\n","export default function*() {\n  for (var groups = this._groups, j = 0, m = groups.length; j < m; ++j) {\n    for (var group = groups[j], i = 0, n = group.length, node; i < n; ++i) {\n      if (node = group[i]) yield node;\n    }\n  }\n}\n","var frame = 0, // is an animation frame pending?\n    timeout = 0, // is a timeout pending?\n    interval = 0, // are any timers active?\n    pokeDelay = 1000, // how frequently we check for clock skew\n    taskHead,\n    taskTail,\n    clockLast = 0,\n    clockNow = 0,\n    clockSkew = 0,\n    clock = typeof performance === \"object\" && performance.now ? performance : Date,\n    setFrame = typeof window === \"object\" && window.requestAnimationFrame ? window.requestAnimationFrame.bind(window) : function(f) { setTimeout(f, 17); };\n\nexport function now() {\n  return clockNow || (setFrame(clearNow), clockNow = clock.now() + clockSkew);\n}\n\nfunction clearNow() {\n  clockNow = 0;\n}\n\nexport function Timer() {\n  this._call =\n  this._time =\n  this._next = null;\n}\n\nTimer.prototype = timer.prototype = {\n  constructor: Timer,\n  restart: function(callback, delay, time) {\n    if (typeof callback !== \"function\") throw new TypeError(\"callback is not a function\");\n    time = (time == null ? now() : +time) + (delay == null ? 0 : +delay);\n    if (!this._next && taskTail !== this) {\n      if (taskTail) taskTail._next = this;\n      else taskHead = this;\n      taskTail = this;\n    }\n    this._call = callback;\n    this._time = time;\n    sleep();\n  },\n  stop: function() {\n    if (this._call) {\n      this._call = null;\n      this._time = Infinity;\n      sleep();\n    }\n  }\n};\n\nexport function timer(callback, delay, time) {\n  var t = new Timer;\n  t.restart(callback, delay, time);\n  return t;\n}\n\nexport function timerFlush() {\n  now(); // Get the current time, if not already set.\n  ++frame; // Pretend we’ve set an alarm, if we haven’t already.\n  var t = taskHead, e;\n  while (t) {\n    if ((e = clockNow - t._time) >= 0) t._call.call(undefined, e);\n    t = t._next;\n  }\n  --frame;\n}\n\nfunction wake() {\n  clockNow = (clockLast = clock.now()) + clockSkew;\n  frame = timeout = 0;\n  try {\n    timerFlush();\n  } finally {\n    frame = 0;\n    nap();\n    clockNow = 0;\n  }\n}\n\nfunction poke() {\n  var now = clock.now(), delay = now - clockLast;\n  if (delay > pokeDelay) clockSkew -= delay, clockLast = now;\n}\n\nfunction nap() {\n  var t0, t1 = taskHead, t2, time = Infinity;\n  while (t1) {\n    if (t1._call) {\n      if (time > t1._time) time = t1._time;\n      t0 = t1, t1 = t1._next;\n    } else {\n      t2 = t1._next, t1._next = null;\n      t1 = t0 ? t0._next = t2 : taskHead = t2;\n    }\n  }\n  taskTail = t0;\n  sleep(time);\n}\n\nfunction sleep(time) {\n  if (frame) return; // Soonest alarm already set, or will be.\n  if (timeout) timeout = clearTimeout(timeout);\n  var delay = time - clockNow; // Strictly less than if we recomputed clockNow.\n  if (delay > 24) {\n    if (time < Infinity) timeout = setTimeout(wake, time - clock.now() - clockSkew);\n    if (interval) interval = clearInterval(interval);\n  } else {\n    if (!interval) clockLast = clock.now(), interval = setInterval(poke, pokeDelay);\n    frame = 1, setFrame(wake);\n  }\n}\n","import {Timer} from \"./timer.js\";\n\nexport default function(callback, delay, time) {\n  var t = new Timer;\n  delay = delay == null ? 0 : +delay;\n  t.restart(elapsed => {\n    t.stop();\n    callback(elapsed + delay);\n  }, delay, time);\n  return t;\n}\n","import {dispatch} from \"d3-dispatch\";\nimport {timer, timeout} from \"d3-timer\";\n\nvar emptyOn = dispatch(\"start\", \"end\", \"cancel\", \"interrupt\");\nvar emptyTween = [];\n\nexport var CREATED = 0;\nexport var SCHEDULED = 1;\nexport var STARTING = 2;\nexport var STARTED = 3;\nexport var RUNNING = 4;\nexport var ENDING = 5;\nexport var ENDED = 6;\n\nexport default function(node, name, id, index, group, timing) {\n  var schedules = node.__transition;\n  if (!schedules) node.__transition = {};\n  else if (id in schedules) return;\n  create(node, id, {\n    name: name,\n    index: index, // For context during callback.\n    group: group, // For context during callback.\n    on: emptyOn,\n    tween: emptyTween,\n    time: timing.time,\n    delay: timing.delay,\n    duration: timing.duration,\n    ease: timing.ease,\n    timer: null,\n    state: CREATED\n  });\n}\n\nexport function init(node, id) {\n  var schedule = get(node, id);\n  if (schedule.state > CREATED) throw new Error(\"too late; already scheduled\");\n  return schedule;\n}\n\nexport function set(node, id) {\n  var schedule = get(node, id);\n  if (schedule.state > STARTED) throw new Error(\"too late; already running\");\n  return schedule;\n}\n\nexport function get(node, id) {\n  var schedule = node.__transition;\n  if (!schedule || !(schedule = schedule[id])) throw new Error(\"transition not found\");\n  return schedule;\n}\n\nfunction create(node, id, self) {\n  var schedules = node.__transition,\n      tween;\n\n  // Initialize the self timer when the transition is created.\n  // Note the actual delay is not known until the first callback!\n  schedules[id] = self;\n  self.timer = timer(schedule, 0, self.time);\n\n  function schedule(elapsed) {\n    self.state = SCHEDULED;\n    self.timer.restart(start, self.delay, self.time);\n\n    // If the elapsed delay is less than our first sleep, start immediately.\n    if (self.delay <= elapsed) start(elapsed - self.delay);\n  }\n\n  function start(elapsed) {\n    var i, j, n, o;\n\n    // If the state is not SCHEDULED, then we previously errored on start.\n    if (self.state !== SCHEDULED) return stop();\n\n    for (i in schedules) {\n      o = schedules[i];\n      if (o.name !== self.name) continue;\n\n      // While this element already has a starting transition during this frame,\n      // defer starting an interrupting transition until that transition has a\n      // chance to tick (and possibly end); see d3/d3-transition#54!\n      if (o.state === STARTED) return timeout(start);\n\n      // Interrupt the active transition, if any.\n      if (o.state === RUNNING) {\n        o.state = ENDED;\n        o.timer.stop();\n        o.on.call(\"interrupt\", node, node.__data__, o.index, o.group);\n        delete schedules[i];\n      }\n\n      // Cancel any pre-empted transitions.\n      else if (+i < id) {\n        o.state = ENDED;\n        o.timer.stop();\n        o.on.call(\"cancel\", node, node.__data__, o.index, o.group);\n        delete schedules[i];\n      }\n    }\n\n    // Defer the first tick to end of the current frame; see d3/d3#1576.\n    // Note the transition may be canceled after start and before the first tick!\n    // Note this must be scheduled before the start event; see d3/d3-transition#16!\n    // Assuming this is successful, subsequent callbacks go straight to tick.\n    timeout(function() {\n      if (self.state === STARTED) {\n        self.state = RUNNING;\n        self.timer.restart(tick, self.delay, self.time);\n        tick(elapsed);\n      }\n    });\n\n    // Dispatch the start event.\n    // Note this must be done before the tween are initialized.\n    self.state = STARTING;\n    self.on.call(\"start\", node, node.__data__, self.index, self.group);\n    if (self.state !== STARTING) return; // interrupted\n    self.state = STARTED;\n\n    // Initialize the tween, deleting null tween.\n    tween = new Array(n = self.tween.length);\n    for (i = 0, j = -1; i < n; ++i) {\n      if (o = self.tween[i].value.call(node, node.__data__, self.index, self.group)) {\n        tween[++j] = o;\n      }\n    }\n    tween.length = j + 1;\n  }\n\n  function tick(elapsed) {\n    var t = elapsed < self.duration ? self.ease.call(null, elapsed / self.duration) : (self.timer.restart(stop), self.state = ENDING, 1),\n        i = -1,\n        n = tween.length;\n\n    while (++i < n) {\n      tween[i].call(node, t);\n    }\n\n    // Dispatch the end event.\n    if (self.state === ENDING) {\n      self.on.call(\"end\", node, node.__data__, self.index, self.group);\n      stop();\n    }\n  }\n\n  function stop() {\n    self.state = ENDED;\n    self.timer.stop();\n    delete schedules[id];\n    for (var i in schedules) return; // eslint-disable-line no-unused-vars\n    delete node.__transition;\n  }\n}\n","import {STARTING, ENDING, ENDED} from \"./transition/schedule.js\";\n\nexport default function(node, name) {\n  var schedules = node.__transition,\n      schedule,\n      active,\n      empty = true,\n      i;\n\n  if (!schedules) return;\n\n  name = name == null ? null : name + \"\";\n\n  for (i in schedules) {\n    if ((schedule = schedules[i]).name !== name) { empty = false; continue; }\n    active = schedule.state > STARTING && schedule.state < ENDING;\n    schedule.state = ENDED;\n    schedule.timer.stop();\n    schedule.on.call(active ? \"interrupt\" : \"cancel\", node, node.__data__, schedule.index, schedule.group);\n    delete schedules[i];\n  }\n\n  if (empty) delete node.__transition;\n}\n","var degrees = 180 / Math.PI;\n\nexport var identity = {\n  translateX: 0,\n  translateY: 0,\n  rotate: 0,\n  skewX: 0,\n  scaleX: 1,\n  scaleY: 1\n};\n\nexport default function(a, b, c, d, e, f) {\n  var scaleX, scaleY, skewX;\n  if (scaleX = Math.sqrt(a * a + b * b)) a /= scaleX, b /= scaleX;\n  if (skewX = a * c + b * d) c -= a * skewX, d -= b * skewX;\n  if (scaleY = Math.sqrt(c * c + d * d)) c /= scaleY, d /= scaleY, skewX /= scaleY;\n  if (a * d < b * c) a = -a, b = -b, skewX = -skewX, scaleX = -scaleX;\n  return {\n    translateX: e,\n    translateY: f,\n    rotate: Math.atan2(b, a) * degrees,\n    skewX: Math.atan(skewX) * degrees,\n    scaleX: scaleX,\n    scaleY: scaleY\n  };\n}\n","import decompose, {identity} from \"./decompose.js\";\n\nvar svgNode;\n\n/* eslint-disable no-undef */\nexport function parseCss(value) {\n  const m = new (typeof DOMMatrix === \"function\" ? DOMMatrix : WebKitCSSMatrix)(value + \"\");\n  return m.isIdentity ? identity : decompose(m.a, m.b, m.c, m.d, m.e, m.f);\n}\n\nexport function parseSvg(value) {\n  if (value == null) return identity;\n  if (!svgNode) svgNode = document.createElementNS(\"http://www.w3.org/2000/svg\", \"g\");\n  svgNode.setAttribute(\"transform\", value);\n  if (!(value = svgNode.transform.baseVal.consolidate())) return identity;\n  value = value.matrix;\n  return decompose(value.a, value.b, value.c, value.d, value.e, value.f);\n}\n","import number from \"../number.js\";\nimport {parseCss, parseSvg} from \"./parse.js\";\n\nfunction interpolateTransform(parse, pxComma, pxParen, degParen) {\n\n  function pop(s) {\n    return s.length ? s.pop() + \" \" : \"\";\n  }\n\n  function translate(xa, ya, xb, yb, s, q) {\n    if (xa !== xb || ya !== yb) {\n      var i = s.push(\"translate(\", null, pxComma, null, pxParen);\n      q.push({i: i - 4, x: number(xa, xb)}, {i: i - 2, x: number(ya, yb)});\n    } else if (xb || yb) {\n      s.push(\"translate(\" + xb + pxComma + yb + pxParen);\n    }\n  }\n\n  function rotate(a, b, s, q) {\n    if (a !== b) {\n      if (a - b > 180) b += 360; else if (b - a > 180) a += 360; // shortest path\n      q.push({i: s.push(pop(s) + \"rotate(\", null, degParen) - 2, x: number(a, b)});\n    } else if (b) {\n      s.push(pop(s) + \"rotate(\" + b + degParen);\n    }\n  }\n\n  function skewX(a, b, s, q) {\n    if (a !== b) {\n      q.push({i: s.push(pop(s) + \"skewX(\", null, degParen) - 2, x: number(a, b)});\n    } else if (b) {\n      s.push(pop(s) + \"skewX(\" + b + degParen);\n    }\n  }\n\n  function scale(xa, ya, xb, yb, s, q) {\n    if (xa !== xb || ya !== yb) {\n      var i = s.push(pop(s) + \"scale(\", null, \",\", null, \")\");\n      q.push({i: i - 4, x: number(xa, xb)}, {i: i - 2, x: number(ya, yb)});\n    } else if (xb !== 1 || yb !== 1) {\n      s.push(pop(s) + \"scale(\" + xb + \",\" + yb + \")\");\n    }\n  }\n\n  return function(a, b) {\n    var s = [], // string constants and placeholders\n        q = []; // number interpolators\n    a = parse(a), b = parse(b);\n    translate(a.translateX, a.translateY, b.translateX, b.translateY, s, q);\n    rotate(a.rotate, b.rotate, s, q);\n    skewX(a.skewX, b.skewX, s, q);\n    scale(a.scaleX, a.scaleY, b.scaleX, b.scaleY, s, q);\n    a = b = null; // gc\n    return function(t) {\n      var i = -1, n = q.length, o;\n      while (++i < n) s[(o = q[i]).i] = o.x(t);\n      return s.join(\"\");\n    };\n  };\n}\n\nexport var interpolateTransformCss = interpolateTransform(parseCss, \"px, \", \"px)\", \"deg)\");\nexport var interpolateTransformSvg = interpolateTransform(parseSvg, \", \", \")\", \")\");\n","import {get, set} from \"./schedule.js\";\n\nfunction tweenRemove(id, name) {\n  var tween0, tween1;\n  return function() {\n    var schedule = set(this, id),\n        tween = schedule.tween;\n\n    // If this node shared tween with the previous node,\n    // just assign the updated shared tween and we’re done!\n    // Otherwise, copy-on-write.\n    if (tween !== tween0) {\n      tween1 = tween0 = tween;\n      for (var i = 0, n = tween1.length; i < n; ++i) {\n        if (tween1[i].name === name) {\n          tween1 = tween1.slice();\n          tween1.splice(i, 1);\n          break;\n        }\n      }\n    }\n\n    schedule.tween = tween1;\n  };\n}\n\nfunction tweenFunction(id, name, value) {\n  var tween0, tween1;\n  if (typeof value !== \"function\") throw new Error;\n  return function() {\n    var schedule = set(this, id),\n        tween = schedule.tween;\n\n    // If this node shared tween with the previous node,\n    // just assign the updated shared tween and we’re done!\n    // Otherwise, copy-on-write.\n    if (tween !== tween0) {\n      tween1 = (tween0 = tween).slice();\n      for (var t = {name: name, value: value}, i = 0, n = tween1.length; i < n; ++i) {\n        if (tween1[i].name === name) {\n          tween1[i] = t;\n          break;\n        }\n      }\n      if (i === n) tween1.push(t);\n    }\n\n    schedule.tween = tween1;\n  };\n}\n\nexport default function(name, value) {\n  var id = this._id;\n\n  name += \"\";\n\n  if (arguments.length < 2) {\n    var tween = get(this.node(), id).tween;\n    for (var i = 0, n = tween.length, t; i < n; ++i) {\n      if ((t = tween[i]).name === name) {\n        return t.value;\n      }\n    }\n    return null;\n  }\n\n  return this.each((value == null ? tweenRemove : tweenFunction)(id, name, value));\n}\n\nexport function tweenValue(transition, name, value) {\n  var id = transition._id;\n\n  transition.each(function() {\n    var schedule = set(this, id);\n    (schedule.value || (schedule.value = {}))[name] = value.apply(this, arguments);\n  });\n\n  return function(node) {\n    return get(node, id).value[name];\n  };\n}\n","import {color} from \"d3-color\";\nimport {interpolateNumber, interpolateRgb, interpolateString} from \"d3-interpolate\";\n\nexport default function(a, b) {\n  var c;\n  return (typeof b === \"number\" ? interpolateNumber\n      : b instanceof color ? interpolateRgb\n      : (c = color(b)) ? (b = c, interpolateRgb)\n      : interpolateString)(a, b);\n}\n","import {interpolateTransformSvg as interpolateTransform} from \"d3-interpolate\";\nimport {namespace} from \"d3-selection\";\nimport {tweenValue} from \"./tween.js\";\nimport interpolate from \"./interpolate.js\";\n\nfunction attrRemove(name) {\n  return function() {\n    this.removeAttribute(name);\n  };\n}\n\nfunction attrRemoveNS(fullname) {\n  return function() {\n    this.removeAttributeNS(fullname.space, fullname.local);\n  };\n}\n\nfunction attrConstant(name, interpolate, value1) {\n  var string00,\n      string1 = value1 + \"\",\n      interpolate0;\n  return function() {\n    var string0 = this.getAttribute(name);\n    return string0 === string1 ? null\n        : string0 === string00 ? interpolate0\n        : interpolate0 = interpolate(string00 = string0, value1);\n  };\n}\n\nfunction attrConstantNS(fullname, interpolate, value1) {\n  var string00,\n      string1 = value1 + \"\",\n      interpolate0;\n  return function() {\n    var string0 = this.getAttributeNS(fullname.space, fullname.local);\n    return string0 === string1 ? null\n        : string0 === string00 ? interpolate0\n        : interpolate0 = interpolate(string00 = string0, value1);\n  };\n}\n\nfunction attrFunction(name, interpolate, value) {\n  var string00,\n      string10,\n      interpolate0;\n  return function() {\n    var string0, value1 = value(this), string1;\n    if (value1 == null) return void this.removeAttribute(name);\n    string0 = this.getAttribute(name);\n    string1 = value1 + \"\";\n    return string0 === string1 ? null\n        : string0 === string00 && string1 === string10 ? interpolate0\n        : (string10 = string1, interpolate0 = interpolate(string00 = string0, value1));\n  };\n}\n\nfunction attrFunctionNS(fullname, interpolate, value) {\n  var string00,\n      string10,\n      interpolate0;\n  return function() {\n    var string0, value1 = value(this), string1;\n    if (value1 == null) return void this.removeAttributeNS(fullname.space, fullname.local);\n    string0 = this.getAttributeNS(fullname.space, fullname.local);\n    string1 = value1 + \"\";\n    return string0 === string1 ? null\n        : string0 === string00 && string1 === string10 ? interpolate0\n        : (string10 = string1, interpolate0 = interpolate(string00 = string0, value1));\n  };\n}\n\nexport default function(name, value) {\n  var fullname = namespace(name), i = fullname === \"transform\" ? interpolateTransform : interpolate;\n  return this.attrTween(name, typeof value === \"function\"\n      ? (fullname.local ? attrFunctionNS : attrFunction)(fullname, i, tweenValue(this, \"attr.\" + name, value))\n      : value == null ? (fullname.local ? attrRemoveNS : attrRemove)(fullname)\n      : (fullname.local ? attrConstantNS : attrConstant)(fullname, i, value));\n}\n","import {namespace} from \"d3-selection\";\n\nfunction attrInterpolate(name, i) {\n  return function(t) {\n    this.setAttribute(name, i.call(this, t));\n  };\n}\n\nfunction attrInterpolateNS(fullname, i) {\n  return function(t) {\n    this.setAttributeNS(fullname.space, fullname.local, i.call(this, t));\n  };\n}\n\nfunction attrTweenNS(fullname, value) {\n  var t0, i0;\n  function tween() {\n    var i = value.apply(this, arguments);\n    if (i !== i0) t0 = (i0 = i) && attrInterpolateNS(fullname, i);\n    return t0;\n  }\n  tween._value = value;\n  return tween;\n}\n\nfunction attrTween(name, value) {\n  var t0, i0;\n  function tween() {\n    var i = value.apply(this, arguments);\n    if (i !== i0) t0 = (i0 = i) && attrInterpolate(name, i);\n    return t0;\n  }\n  tween._value = value;\n  return tween;\n}\n\nexport default function(name, value) {\n  var key = \"attr.\" + name;\n  if (arguments.length < 2) return (key = this.tween(key)) && key._value;\n  if (value == null) return this.tween(key, null);\n  if (typeof value !== \"function\") throw new Error;\n  var fullname = namespace(name);\n  return this.tween(key, (fullname.local ? attrTweenNS : attrTween)(fullname, value));\n}\n","import {get, init} from \"./schedule.js\";\n\nfunction delayFunction(id, value) {\n  return function() {\n    init(this, id).delay = +value.apply(this, arguments);\n  };\n}\n\nfunction delayConstant(id, value) {\n  return value = +value, function() {\n    init(this, id).delay = value;\n  };\n}\n\nexport default function(value) {\n  var id = this._id;\n\n  return arguments.length\n      ? this.each((typeof value === \"function\"\n          ? delayFunction\n          : delayConstant)(id, value))\n      : get(this.node(), id).delay;\n}\n","import {get, set} from \"./schedule.js\";\n\nfunction durationFunction(id, value) {\n  return function() {\n    set(this, id).duration = +value.apply(this, arguments);\n  };\n}\n\nfunction durationConstant(id, value) {\n  return value = +value, function() {\n    set(this, id).duration = value;\n  };\n}\n\nexport default function(value) {\n  var id = this._id;\n\n  return arguments.length\n      ? this.each((typeof value === \"function\"\n          ? durationFunction\n          : durationConstant)(id, value))\n      : get(this.node(), id).duration;\n}\n","import {get, set} from \"./schedule.js\";\n\nfunction easeConstant(id, value) {\n  if (typeof value !== \"function\") throw new Error;\n  return function() {\n    set(this, id).ease = value;\n  };\n}\n\nexport default function(value) {\n  var id = this._id;\n\n  return arguments.length\n      ? this.each(easeConstant(id, value))\n      : get(this.node(), id).ease;\n}\n","import {get, set, init} from \"./schedule.js\";\n\nfunction start(name) {\n  return (name + \"\").trim().split(/^|\\s+/).every(function(t) {\n    var i = t.indexOf(\".\");\n    if (i >= 0) t = t.slice(0, i);\n    return !t || t === \"start\";\n  });\n}\n\nfunction onFunction(id, name, listener) {\n  var on0, on1, sit = start(name) ? init : set;\n  return function() {\n    var schedule = sit(this, id),\n        on = schedule.on;\n\n    // If this node shared a dispatch with the previous node,\n    // just assign the updated shared dispatch and we’re done!\n    // Otherwise, copy-on-write.\n    if (on !== on0) (on1 = (on0 = on).copy()).on(name, listener);\n\n    schedule.on = on1;\n  };\n}\n\nexport default function(name, listener) {\n  var id = this._id;\n\n  return arguments.length < 2\n      ? get(this.node(), id).on.on(name)\n      : this.each(onFunction(id, name, listener));\n}\n","import {selection} from \"d3-selection\";\n\nvar Selection = selection.prototype.constructor;\n\nexport default function() {\n  return new Selection(this._groups, this._parents);\n}\n","import {interpolateTransformCss as interpolateTransform} from \"d3-interpolate\";\nimport {style} from \"d3-selection\";\nimport {set} from \"./schedule.js\";\nimport {tweenValue} from \"./tween.js\";\nimport interpolate from \"./interpolate.js\";\n\nfunction styleNull(name, interpolate) {\n  var string00,\n      string10,\n      interpolate0;\n  return function() {\n    var string0 = style(this, name),\n        string1 = (this.style.removeProperty(name), style(this, name));\n    return string0 === string1 ? null\n        : string0 === string00 && string1 === string10 ? interpolate0\n        : interpolate0 = interpolate(string00 = string0, string10 = string1);\n  };\n}\n\nfunction styleRemove(name) {\n  return function() {\n    this.style.removeProperty(name);\n  };\n}\n\nfunction styleConstant(name, interpolate, value1) {\n  var string00,\n      string1 = value1 + \"\",\n      interpolate0;\n  return function() {\n    var string0 = style(this, name);\n    return string0 === string1 ? null\n        : string0 === string00 ? interpolate0\n        : interpolate0 = interpolate(string00 = string0, value1);\n  };\n}\n\nfunction styleFunction(name, interpolate, value) {\n  var string00,\n      string10,\n      interpolate0;\n  return function() {\n    var string0 = style(this, name),\n        value1 = value(this),\n        string1 = value1 + \"\";\n    if (value1 == null) string1 = value1 = (this.style.removeProperty(name), style(this, name));\n    return string0 === string1 ? null\n        : string0 === string00 && string1 === string10 ? interpolate0\n        : (string10 = string1, interpolate0 = interpolate(string00 = string0, value1));\n  };\n}\n\nfunction styleMaybeRemove(id, name) {\n  var on0, on1, listener0, key = \"style.\" + name, event = \"end.\" + key, remove;\n  return function() {\n    var schedule = set(this, id),\n        on = schedule.on,\n        listener = schedule.value[key] == null ? remove || (remove = styleRemove(name)) : undefined;\n\n    // If this node shared a dispatch with the previous node,\n    // just assign the updated shared dispatch and we’re done!\n    // Otherwise, copy-on-write.\n    if (on !== on0 || listener0 !== listener) (on1 = (on0 = on).copy()).on(event, listener0 = listener);\n\n    schedule.on = on1;\n  };\n}\n\nexport default function(name, value, priority) {\n  var i = (name += \"\") === \"transform\" ? interpolateTransform : interpolate;\n  return value == null ? this\n      .styleTween(name, styleNull(name, i))\n      .on(\"end.style.\" + name, styleRemove(name))\n    : typeof value === \"function\" ? this\n      .styleTween(name, styleFunction(name, i, tweenValue(this, \"style.\" + name, value)))\n      .each(styleMaybeRemove(this._id, name))\n    : this\n      .styleTween(name, styleConstant(name, i, value), priority)\n      .on(\"end.style.\" + name, null);\n}\n","function styleInterpolate(name, i, priority) {\n  return function(t) {\n    this.style.setProperty(name, i.call(this, t), priority);\n  };\n}\n\nfunction styleTween(name, value, priority) {\n  var t, i0;\n  function tween() {\n    var i = value.apply(this, arguments);\n    if (i !== i0) t = (i0 = i) && styleInterpolate(name, i, priority);\n    return t;\n  }\n  tween._value = value;\n  return tween;\n}\n\nexport default function(name, value, priority) {\n  var key = \"style.\" + (name += \"\");\n  if (arguments.length < 2) return (key = this.tween(key)) && key._value;\n  if (value == null) return this.tween(key, null);\n  if (typeof value !== \"function\") throw new Error;\n  return this.tween(key, styleTween(name, value, priority == null ? \"\" : priority));\n}\n","function textInterpolate(i) {\n  return function(t) {\n    this.textContent = i.call(this, t);\n  };\n}\n\nfunction textTween(value) {\n  var t0, i0;\n  function tween() {\n    var i = value.apply(this, arguments);\n    if (i !== i0) t0 = (i0 = i) && textInterpolate(i);\n    return t0;\n  }\n  tween._value = value;\n  return tween;\n}\n\nexport default function(value) {\n  var key = \"text\";\n  if (arguments.length < 1) return (key = this.tween(key)) && key._value;\n  if (value == null) return this.tween(key, null);\n  if (typeof value !== \"function\") throw new Error;\n  return this.tween(key, textTween(value));\n}\n","import {selection} from \"d3-selection\";\nimport transition_attr from \"./attr.js\";\nimport transition_attrTween from \"./attrTween.js\";\nimport transition_delay from \"./delay.js\";\nimport transition_duration from \"./duration.js\";\nimport transition_ease from \"./ease.js\";\nimport transition_easeVarying from \"./easeVarying.js\";\nimport transition_filter from \"./filter.js\";\nimport transition_merge from \"./merge.js\";\nimport transition_on from \"./on.js\";\nimport transition_remove from \"./remove.js\";\nimport transition_select from \"./select.js\";\nimport transition_selectAll from \"./selectAll.js\";\nimport transition_selection from \"./selection.js\";\nimport transition_style from \"./style.js\";\nimport transition_styleTween from \"./styleTween.js\";\nimport transition_text from \"./text.js\";\nimport transition_textTween from \"./textTween.js\";\nimport transition_transition from \"./transition.js\";\nimport transition_tween from \"./tween.js\";\nimport transition_end from \"./end.js\";\n\nvar id = 0;\n\nexport function Transition(groups, parents, name, id) {\n  this._groups = groups;\n  this._parents = parents;\n  this._name = name;\n  this._id = id;\n}\n\nexport default function transition(name) {\n  return selection().transition(name);\n}\n\nexport function newId() {\n  return ++id;\n}\n\nvar selection_prototype = selection.prototype;\n\nTransition.prototype = transition.prototype = {\n  constructor: Transition,\n  select: transition_select,\n  selectAll: transition_selectAll,\n  selectChild: selection_prototype.selectChild,\n  selectChildren: selection_prototype.selectChildren,\n  filter: transition_filter,\n  merge: transition_merge,\n  selection: transition_selection,\n  transition: transition_transition,\n  call: selection_prototype.call,\n  nodes: selection_prototype.nodes,\n  node: selection_prototype.node,\n  size: selection_prototype.size,\n  empty: selection_prototype.empty,\n  each: selection_prototype.each,\n  on: transition_on,\n  attr: transition_attr,\n  attrTween: transition_attrTween,\n  style: transition_style,\n  styleTween: transition_styleTween,\n  text: transition_text,\n  textTween: transition_textTween,\n  remove: transition_remove,\n  tween: transition_tween,\n  delay: transition_delay,\n  duration: transition_duration,\n  ease: transition_ease,\n  easeVarying: transition_easeVarying,\n  end: transition_end,\n  [Symbol.iterator]: selection_prototype[Symbol.iterator]\n};\n","import {selector} from \"d3-selection\";\nimport {Transition} from \"./index.js\";\nimport schedule, {get} from \"./schedule.js\";\n\nexport default function(select) {\n  var name = this._name,\n      id = this._id;\n\n  if (typeof select !== \"function\") select = selector(select);\n\n  for (var groups = this._groups, m = groups.length, subgroups = new Array(m), j = 0; j < m; ++j) {\n    for (var group = groups[j], n = group.length, subgroup = subgroups[j] = new Array(n), node, subnode, i = 0; i < n; ++i) {\n      if ((node = group[i]) && (subnode = select.call(node, node.__data__, i, group))) {\n        if (\"__data__\" in node) subnode.__data__ = node.__data__;\n        subgroup[i] = subnode;\n        schedule(subgroup[i], name, id, i, subgroup, get(node, id));\n      }\n    }\n  }\n\n  return new Transition(subgroups, this._parents, name, id);\n}\n","import {selectorAll} from \"d3-selection\";\nimport {Transition} from \"./index.js\";\nimport schedule, {get} from \"./schedule.js\";\n\nexport default function(select) {\n  var name = this._name,\n      id = this._id;\n\n  if (typeof select !== \"function\") select = selectorAll(select);\n\n  for (var groups = this._groups, m = groups.length, subgroups = [], parents = [], j = 0; j < m; ++j) {\n    for (var group = groups[j], n = group.length, node, i = 0; i < n; ++i) {\n      if (node = group[i]) {\n        for (var children = select.call(node, node.__data__, i, group), child, inherit = get(node, id), k = 0, l = children.length; k < l; ++k) {\n          if (child = children[k]) {\n            schedule(child, name, id, k, children, inherit);\n          }\n        }\n        subgroups.push(children);\n        parents.push(node);\n      }\n    }\n  }\n\n  return new Transition(subgroups, parents, name, id);\n}\n","import {matcher} from \"d3-selection\";\nimport {Transition} from \"./index.js\";\n\nexport default function(match) {\n  if (typeof match !== \"function\") match = matcher(match);\n\n  for (var groups = this._groups, m = groups.length, subgroups = new Array(m), j = 0; j < m; ++j) {\n    for (var group = groups[j], n = group.length, subgroup = subgroups[j] = [], node, i = 0; i < n; ++i) {\n      if ((node = group[i]) && match.call(node, node.__data__, i, group)) {\n        subgroup.push(node);\n      }\n    }\n  }\n\n  return new Transition(subgroups, this._parents, this._name, this._id);\n}\n","import {Transition} from \"./index.js\";\n\nexport default function(transition) {\n  if (transition._id !== this._id) throw new Error;\n\n  for (var groups0 = this._groups, groups1 = transition._groups, m0 = groups0.length, m1 = groups1.length, m = Math.min(m0, m1), merges = new Array(m0), j = 0; j < m; ++j) {\n    for (var group0 = groups0[j], group1 = groups1[j], n = group0.length, merge = merges[j] = new Array(n), node, i = 0; i < n; ++i) {\n      if (node = group0[i] || group1[i]) {\n        merge[i] = node;\n      }\n    }\n  }\n\n  for (; j < m0; ++j) {\n    merges[j] = groups0[j];\n  }\n\n  return new Transition(merges, this._parents, this._name, this._id);\n}\n","import {Transition, newId} from \"./index.js\";\nimport schedule, {get} from \"./schedule.js\";\n\nexport default function() {\n  var name = this._name,\n      id0 = this._id,\n      id1 = newId();\n\n  for (var groups = this._groups, m = groups.length, j = 0; j < m; ++j) {\n    for (var group = groups[j], n = group.length, node, i = 0; i < n; ++i) {\n      if (node = group[i]) {\n        var inherit = get(node, id0);\n        schedule(node, name, id1, i, group, {\n          time: inherit.time + inherit.delay + inherit.duration,\n          delay: 0,\n          duration: inherit.duration,\n          ease: inherit.ease\n        });\n      }\n    }\n  }\n\n  return new Transition(groups, this._parents, name, id1);\n}\n","import {tweenValue} from \"./tween.js\";\n\nfunction textConstant(value) {\n  return function() {\n    this.textContent = value;\n  };\n}\n\nfunction textFunction(value) {\n  return function() {\n    var value1 = value(this);\n    this.textContent = value1 == null ? \"\" : value1;\n  };\n}\n\nexport default function(value) {\n  return this.tween(\"text\", typeof value === \"function\"\n      ? textFunction(tweenValue(this, \"text\", value))\n      : textConstant(value == null ? \"\" : value + \"\"));\n}\n","function removeFunction(id) {\n  return function() {\n    var parent = this.parentNode;\n    for (var i in this.__transition) if (+i !== id) return;\n    if (parent) parent.removeChild(this);\n  };\n}\n\nexport default function() {\n  return this.on(\"end.remove\", removeFunction(this._id));\n}\n","import {set} from \"./schedule.js\";\n\nfunction easeVarying(id, value) {\n  return function() {\n    var v = value.apply(this, arguments);\n    if (typeof v !== \"function\") throw new Error;\n    set(this, id).ease = v;\n  };\n}\n\nexport default function(value) {\n  if (typeof value !== \"function\") throw new Error;\n  return this.each(easeVarying(this._id, value));\n}\n","import {set} from \"./schedule.js\";\n\nexport default function() {\n  var on0, on1, that = this, id = that._id, size = that.size();\n  return new Promise(function(resolve, reject) {\n    var cancel = {value: reject},\n        end = {value: function() { if (--size === 0) resolve(); }};\n\n    that.each(function() {\n      var schedule = set(this, id),\n          on = schedule.on;\n\n      // If this node shared a dispatch with the previous node,\n      // just assign the updated shared dispatch and we’re done!\n      // Otherwise, copy-on-write.\n      if (on !== on0) {\n        on1 = (on0 = on).copy();\n        on1._.cancel.push(cancel);\n        on1._.interrupt.push(cancel);\n        on1._.end.push(end);\n      }\n\n      schedule.on = on1;\n    });\n\n    // The selection was empty, resolve end immediately\n    if (size === 0) resolve();\n  });\n}\n","import {Transition, newId} from \"../transition/index.js\";\nimport schedule from \"../transition/schedule.js\";\nimport {easeCubicInOut} from \"d3-ease\";\nimport {now} from \"d3-timer\";\n\nvar defaultTiming = {\n  time: null, // Set on use.\n  delay: 0,\n  duration: 250,\n  ease: easeCubicInOut\n};\n\nfunction inherit(node, id) {\n  var timing;\n  while (!(timing = node.__transition) || !(timing = timing[id])) {\n    if (!(node = node.parentNode)) {\n      throw new Error(`transition ${id} not found`);\n    }\n  }\n  return timing;\n}\n\nexport default function(name) {\n  var id,\n      timing;\n\n  if (name instanceof Transition) {\n    id = name._id, name = name._name;\n  } else {\n    id = newId(), (timing = defaultTiming).time = now(), name = name == null ? null : name + \"\";\n  }\n\n  for (var groups = this._groups, m = groups.length, j = 0; j < m; ++j) {\n    for (var group = groups[j], n = group.length, node, i = 0; i < n; ++i) {\n      if (node = group[i]) {\n        schedule(node, name, id, i, group, timing || inherit(node, id));\n      }\n    }\n  }\n\n  return new Transition(groups, this._parents, name, id);\n}\n","export function cubicIn(t) {\n  return t * t * t;\n}\n\nexport function cubicOut(t) {\n  return --t * t * t + 1;\n}\n\nexport function cubicInOut(t) {\n  return ((t *= 2) <= 1 ? t * t * t : (t -= 2) * t * t + 2) / 2;\n}\n","import {selection} from \"d3-selection\";\nimport selection_interrupt from \"./interrupt.js\";\nimport selection_transition from \"./transition.js\";\n\nselection.prototype.interrupt = selection_interrupt;\nselection.prototype.transition = selection_transition;\n","import interrupt from \"../interrupt.js\";\n\nexport default function(name) {\n  return this.each(function() {\n    interrupt(this, name);\n  });\n}\n","export default x => () => x;\n","export default function BrushEvent(type, {\n  sourceEvent,\n  target,\n  selection,\n  mode,\n  dispatch\n}) {\n  Object.defineProperties(this, {\n    type: {value: type, enumerable: true, configurable: true},\n    sourceEvent: {value: sourceEvent, enumerable: true, configurable: true},\n    target: {value: target, enumerable: true, configurable: true},\n    selection: {value: selection, enumerable: true, configurable: true},\n    mode: {value: mode, enumerable: true, configurable: true},\n    _: {value: dispatch}\n  });\n}\n","export function nopropagation(event) {\n  event.stopImmediatePropagation();\n}\n\nexport default function(event) {\n  event.preventDefault();\n  event.stopImmediatePropagation();\n}\n","import {dispatch} from \"d3-dispatch\";\nimport {dragDisable, dragEnable} from \"d3-drag\";\nimport {interpolate} from \"d3-interpolate\";\nimport {pointer, select} from \"d3-selection\";\nimport {interrupt} from \"d3-transition\";\nimport constant from \"./constant.js\";\nimport BrushEvent from \"./event.js\";\nimport noevent, {nopropagation} from \"./noevent.js\";\n\nvar MODE_DRAG = {name: \"drag\"},\n    MODE_SPACE = {name: \"space\"},\n    MODE_HANDLE = {name: \"handle\"},\n    MODE_CENTER = {name: \"center\"};\n\nconst {abs, max, min} = Math;\n\nfunction number1(e) {\n  return [+e[0], +e[1]];\n}\n\nfunction number2(e) {\n  return [number1(e[0]), number1(e[1])];\n}\n\nvar X = {\n  name: \"x\",\n  handles: [\"w\", \"e\"].map(type),\n  input: function(x, e) { return x == null ? null : [[+x[0], e[0][1]], [+x[1], e[1][1]]]; },\n  output: function(xy) { return xy && [xy[0][0], xy[1][0]]; }\n};\n\nvar Y = {\n  name: \"y\",\n  handles: [\"n\", \"s\"].map(type),\n  input: function(y, e) { return y == null ? null : [[e[0][0], +y[0]], [e[1][0], +y[1]]]; },\n  output: function(xy) { return xy && [xy[0][1], xy[1][1]]; }\n};\n\nvar XY = {\n  name: \"xy\",\n  handles: [\"n\", \"w\", \"e\", \"s\", \"nw\", \"ne\", \"sw\", \"se\"].map(type),\n  input: function(xy) { return xy == null ? null : number2(xy); },\n  output: function(xy) { return xy; }\n};\n\nvar cursors = {\n  overlay: \"crosshair\",\n  selection: \"move\",\n  n: \"ns-resize\",\n  e: \"ew-resize\",\n  s: \"ns-resize\",\n  w: \"ew-resize\",\n  nw: \"nwse-resize\",\n  ne: \"nesw-resize\",\n  se: \"nwse-resize\",\n  sw: \"nesw-resize\"\n};\n\nvar flipX = {\n  e: \"w\",\n  w: \"e\",\n  nw: \"ne\",\n  ne: \"nw\",\n  se: \"sw\",\n  sw: \"se\"\n};\n\nvar flipY = {\n  n: \"s\",\n  s: \"n\",\n  nw: \"sw\",\n  ne: \"se\",\n  se: \"ne\",\n  sw: \"nw\"\n};\n\nvar signsX = {\n  overlay: +1,\n  selection: +1,\n  n: null,\n  e: +1,\n  s: null,\n  w: -1,\n  nw: -1,\n  ne: +1,\n  se: +1,\n  sw: -1\n};\n\nvar signsY = {\n  overlay: +1,\n  selection: +1,\n  n: -1,\n  e: null,\n  s: +1,\n  w: null,\n  nw: -1,\n  ne: -1,\n  se: +1,\n  sw: +1\n};\n\nfunction type(t) {\n  return {type: t};\n}\n\n// Ignore right-click, since that should open the context menu.\nfunction defaultFilter(event) {\n  return !event.ctrlKey && !event.button;\n}\n\nfunction defaultExtent() {\n  var svg = this.ownerSVGElement || this;\n  if (svg.hasAttribute(\"viewBox\")) {\n    svg = svg.viewBox.baseVal;\n    return [[svg.x, svg.y], [svg.x + svg.width, svg.y + svg.height]];\n  }\n  return [[0, 0], [svg.width.baseVal.value, svg.height.baseVal.value]];\n}\n\nfunction defaultTouchable() {\n  return navigator.maxTouchPoints || (\"ontouchstart\" in this);\n}\n\n// Like d3.local, but with the name “__brush” rather than auto-generated.\nfunction local(node) {\n  while (!node.__brush) if (!(node = node.parentNode)) return;\n  return node.__brush;\n}\n\nfunction empty(extent) {\n  return extent[0][0] === extent[1][0]\n      || extent[0][1] === extent[1][1];\n}\n\nexport function brushSelection(node) {\n  var state = node.__brush;\n  return state ? state.dim.output(state.selection) : null;\n}\n\nexport function brushX() {\n  return brush(X);\n}\n\nexport function brushY() {\n  return brush(Y);\n}\n\nexport default function() {\n  return brush(XY);\n}\n\nfunction brush(dim) {\n  var extent = defaultExtent,\n      filter = defaultFilter,\n      touchable = defaultTouchable,\n      keys = true,\n      listeners = dispatch(\"start\", \"brush\", \"end\"),\n      handleSize = 6,\n      touchending;\n\n  function brush(group) {\n    var overlay = group\n        .property(\"__brush\", initialize)\n      .selectAll(\".overlay\")\n      .data([type(\"overlay\")]);\n\n    overlay.enter().append(\"rect\")\n        .attr(\"class\", \"overlay\")\n        .attr(\"pointer-events\", \"all\")\n        .attr(\"cursor\", cursors.overlay)\n      .merge(overlay)\n        .each(function() {\n          var extent = local(this).extent;\n          select(this)\n              .attr(\"x\", extent[0][0])\n              .attr(\"y\", extent[0][1])\n              .attr(\"width\", extent[1][0] - extent[0][0])\n              .attr(\"height\", extent[1][1] - extent[0][1]);\n        });\n\n    group.selectAll(\".selection\")\n      .data([type(\"selection\")])\n      .enter().append(\"rect\")\n        .attr(\"class\", \"selection\")\n        .attr(\"cursor\", cursors.selection)\n        .attr(\"fill\", \"#777\")\n        .attr(\"fill-opacity\", 0.3)\n        .attr(\"stroke\", \"#fff\")\n        .attr(\"shape-rendering\", \"crispEdges\");\n\n    var handle = group.selectAll(\".handle\")\n      .data(dim.handles, function(d) { return d.type; });\n\n    handle.exit().remove();\n\n    handle.enter().append(\"rect\")\n        .attr(\"class\", function(d) { return \"handle handle--\" + d.type; })\n        .attr(\"cursor\", function(d) { return cursors[d.type]; });\n\n    group\n        .each(redraw)\n        .attr(\"fill\", \"none\")\n        .attr(\"pointer-events\", \"all\")\n        .on(\"mousedown.brush\", started)\n      .filter(touchable)\n        .on(\"touchstart.brush\", started)\n        .on(\"touchmove.brush\", touchmoved)\n        .on(\"touchend.brush touchcancel.brush\", touchended)\n        .style(\"touch-action\", \"none\")\n        .style(\"-webkit-tap-highlight-color\", \"rgba(0,0,0,0)\");\n  }\n\n  brush.move = function(group, selection, event) {\n    if (group.tween) {\n      group\n          .on(\"start.brush\", function(event) { emitter(this, arguments).beforestart().start(event); })\n          .on(\"interrupt.brush end.brush\", function(event) { emitter(this, arguments).end(event); })\n          .tween(\"brush\", function() {\n            var that = this,\n                state = that.__brush,\n                emit = emitter(that, arguments),\n                selection0 = state.selection,\n                selection1 = dim.input(typeof selection === \"function\" ? selection.apply(this, arguments) : selection, state.extent),\n                i = interpolate(selection0, selection1);\n\n            function tween(t) {\n              state.selection = t === 1 && selection1 === null ? null : i(t);\n              redraw.call(that);\n              emit.brush();\n            }\n\n            return selection0 !== null && selection1 !== null ? tween : tween(1);\n          });\n    } else {\n      group\n          .each(function() {\n            var that = this,\n                args = arguments,\n                state = that.__brush,\n                selection1 = dim.input(typeof selection === \"function\" ? selection.apply(that, args) : selection, state.extent),\n                emit = emitter(that, args).beforestart();\n\n            interrupt(that);\n            state.selection = selection1 === null ? null : selection1;\n            redraw.call(that);\n            emit.start(event).brush(event).end(event);\n          });\n    }\n  };\n\n  brush.clear = function(group, event) {\n    brush.move(group, null, event);\n  };\n\n  function redraw() {\n    var group = select(this),\n        selection = local(this).selection;\n\n    if (selection) {\n      group.selectAll(\".selection\")\n          .style(\"display\", null)\n          .attr(\"x\", selection[0][0])\n          .attr(\"y\", selection[0][1])\n          .attr(\"width\", selection[1][0] - selection[0][0])\n          .attr(\"height\", selection[1][1] - selection[0][1]);\n\n      group.selectAll(\".handle\")\n          .style(\"display\", null)\n          .attr(\"x\", function(d) { return d.type[d.type.length - 1] === \"e\" ? selection[1][0] - handleSize / 2 : selection[0][0] - handleSize / 2; })\n          .attr(\"y\", function(d) { return d.type[0] === \"s\" ? selection[1][1] - handleSize / 2 : selection[0][1] - handleSize / 2; })\n          .attr(\"width\", function(d) { return d.type === \"n\" || d.type === \"s\" ? selection[1][0] - selection[0][0] + handleSize : handleSize; })\n          .attr(\"height\", function(d) { return d.type === \"e\" || d.type === \"w\" ? selection[1][1] - selection[0][1] + handleSize : handleSize; });\n    }\n\n    else {\n      group.selectAll(\".selection,.handle\")\n          .style(\"display\", \"none\")\n          .attr(\"x\", null)\n          .attr(\"y\", null)\n          .attr(\"width\", null)\n          .attr(\"height\", null);\n    }\n  }\n\n  function emitter(that, args, clean) {\n    var emit = that.__brush.emitter;\n    return emit && (!clean || !emit.clean) ? emit : new Emitter(that, args, clean);\n  }\n\n  function Emitter(that, args, clean) {\n    this.that = that;\n    this.args = args;\n    this.state = that.__brush;\n    this.active = 0;\n    this.clean = clean;\n  }\n\n  Emitter.prototype = {\n    beforestart: function() {\n      if (++this.active === 1) this.state.emitter = this, this.starting = true;\n      return this;\n    },\n    start: function(event, mode) {\n      if (this.starting) this.starting = false, this.emit(\"start\", event, mode);\n      else this.emit(\"brush\", event);\n      return this;\n    },\n    brush: function(event, mode) {\n      this.emit(\"brush\", event, mode);\n      return this;\n    },\n    end: function(event, mode) {\n      if (--this.active === 0) delete this.state.emitter, this.emit(\"end\", event, mode);\n      return this;\n    },\n    emit: function(type, event, mode) {\n      var d = select(this.that).datum();\n      listeners.call(\n        type,\n        this.that,\n        new BrushEvent(type, {\n          sourceEvent: event,\n          target: brush,\n          selection: dim.output(this.state.selection),\n          mode,\n          dispatch: listeners\n        }),\n        d\n      );\n    }\n  };\n\n  function started(event) {\n    if (touchending && !event.touches) return;\n    if (!filter.apply(this, arguments)) return;\n\n    var that = this,\n        type = event.target.__data__.type,\n        mode = (keys && event.metaKey ? type = \"overlay\" : type) === \"selection\" ? MODE_DRAG : (keys && event.altKey ? MODE_CENTER : MODE_HANDLE),\n        signX = dim === Y ? null : signsX[type],\n        signY = dim === X ? null : signsY[type],\n        state = local(that),\n        extent = state.extent,\n        selection = state.selection,\n        W = extent[0][0], w0, w1,\n        N = extent[0][1], n0, n1,\n        E = extent[1][0], e0, e1,\n        S = extent[1][1], s0, s1,\n        dx = 0,\n        dy = 0,\n        moving,\n        shifting = signX && signY && keys && event.shiftKey,\n        lockX,\n        lockY,\n        points = Array.from(event.touches || [event], t => {\n          const i = t.identifier;\n          t = pointer(t, that);\n          t.point0 = t.slice();\n          t.identifier = i;\n          return t;\n        });\n\n    interrupt(that);\n    var emit = emitter(that, arguments, true).beforestart();\n\n    if (type === \"overlay\") {\n      if (selection) moving = true;\n      const pts = [points[0], points[1] || points[0]];\n      state.selection = selection = [[\n          w0 = dim === Y ? W : min(pts[0][0], pts[1][0]),\n          n0 = dim === X ? N : min(pts[0][1], pts[1][1])\n        ], [\n          e0 = dim === Y ? E : max(pts[0][0], pts[1][0]),\n          s0 = dim === X ? S : max(pts[0][1], pts[1][1])\n        ]];\n      if (points.length > 1) move(event);\n    } else {\n      w0 = selection[0][0];\n      n0 = selection[0][1];\n      e0 = selection[1][0];\n      s0 = selection[1][1];\n    }\n\n    w1 = w0;\n    n1 = n0;\n    e1 = e0;\n    s1 = s0;\n\n    var group = select(that)\n        .attr(\"pointer-events\", \"none\");\n\n    var overlay = group.selectAll(\".overlay\")\n        .attr(\"cursor\", cursors[type]);\n\n    if (event.touches) {\n      emit.moved = moved;\n      emit.ended = ended;\n    } else {\n      var view = select(event.view)\n          .on(\"mousemove.brush\", moved, true)\n          .on(\"mouseup.brush\", ended, true);\n      if (keys) view\n          .on(\"keydown.brush\", keydowned, true)\n          .on(\"keyup.brush\", keyupped, true)\n\n      dragDisable(event.view);\n    }\n\n    redraw.call(that);\n    emit.start(event, mode.name);\n\n    function moved(event) {\n      for (const p of event.changedTouches || [event]) {\n        for (const d of points)\n          if (d.identifier === p.identifier) d.cur = pointer(p, that);\n      }\n      if (shifting && !lockX && !lockY && points.length === 1) {\n        const point = points[0];\n        if (abs(point.cur[0] - point[0]) > abs(point.cur[1] - point[1]))\n          lockY = true;\n        else\n          lockX = true;\n      }\n      for (const point of points)\n        if (point.cur) point[0] = point.cur[0], point[1] = point.cur[1];\n      moving = true;\n      noevent(event);\n      move(event);\n    }\n\n    function move(event) {\n      const point = points[0], point0 = point.point0;\n      var t;\n\n      dx = point[0] - point0[0];\n      dy = point[1] - point0[1];\n\n      switch (mode) {\n        case MODE_SPACE:\n        case MODE_DRAG: {\n          if (signX) dx = max(W - w0, min(E - e0, dx)), w1 = w0 + dx, e1 = e0 + dx;\n          if (signY) dy = max(N - n0, min(S - s0, dy)), n1 = n0 + dy, s1 = s0 + dy;\n          break;\n        }\n        case MODE_HANDLE: {\n          if (points[1]) {\n            if (signX) w1 = max(W, min(E, points[0][0])), e1 = max(W, min(E, points[1][0])), signX = 1;\n            if (signY) n1 = max(N, min(S, points[0][1])), s1 = max(N, min(S, points[1][1])), signY = 1;\n          } else {\n            if (signX < 0) dx = max(W - w0, min(E - w0, dx)), w1 = w0 + dx, e1 = e0;\n            else if (signX > 0) dx = max(W - e0, min(E - e0, dx)), w1 = w0, e1 = e0 + dx;\n            if (signY < 0) dy = max(N - n0, min(S - n0, dy)), n1 = n0 + dy, s1 = s0;\n            else if (signY > 0) dy = max(N - s0, min(S - s0, dy)), n1 = n0, s1 = s0 + dy;\n          }\n          break;\n        }\n        case MODE_CENTER: {\n          if (signX) w1 = max(W, min(E, w0 - dx * signX)), e1 = max(W, min(E, e0 + dx * signX));\n          if (signY) n1 = max(N, min(S, n0 - dy * signY)), s1 = max(N, min(S, s0 + dy * signY));\n          break;\n        }\n      }\n\n      if (e1 < w1) {\n        signX *= -1;\n        t = w0, w0 = e0, e0 = t;\n        t = w1, w1 = e1, e1 = t;\n        if (type in flipX) overlay.attr(\"cursor\", cursors[type = flipX[type]]);\n      }\n\n      if (s1 < n1) {\n        signY *= -1;\n        t = n0, n0 = s0, s0 = t;\n        t = n1, n1 = s1, s1 = t;\n        if (type in flipY) overlay.attr(\"cursor\", cursors[type = flipY[type]]);\n      }\n\n      if (state.selection) selection = state.selection; // May be set by brush.move!\n      if (lockX) w1 = selection[0][0], e1 = selection[1][0];\n      if (lockY) n1 = selection[0][1], s1 = selection[1][1];\n\n      if (selection[0][0] !== w1\n          || selection[0][1] !== n1\n          || selection[1][0] !== e1\n          || selection[1][1] !== s1) {\n        state.selection = [[w1, n1], [e1, s1]];\n        redraw.call(that);\n        emit.brush(event, mode.name);\n      }\n    }\n\n    function ended(event) {\n      nopropagation(event);\n      if (event.touches) {\n        if (event.touches.length) return;\n        if (touchending) clearTimeout(touchending);\n        touchending = setTimeout(function() { touchending = null; }, 500); // Ghost clicks are delayed!\n      } else {\n        dragEnable(event.view, moving);\n        view.on(\"keydown.brush keyup.brush mousemove.brush mouseup.brush\", null);\n      }\n      group.attr(\"pointer-events\", \"all\");\n      overlay.attr(\"cursor\", cursors.overlay);\n      if (state.selection) selection = state.selection; // May be set by brush.move (on start)!\n      if (empty(selection)) state.selection = null, redraw.call(that);\n      emit.end(event, mode.name);\n    }\n\n    function keydowned(event) {\n      switch (event.keyCode) {\n        case 16: { // SHIFT\n          shifting = signX && signY;\n          break;\n        }\n        case 18: { // ALT\n          if (mode === MODE_HANDLE) {\n            if (signX) e0 = e1 - dx * signX, w0 = w1 + dx * signX;\n            if (signY) s0 = s1 - dy * signY, n0 = n1 + dy * signY;\n            mode = MODE_CENTER;\n            move(event);\n          }\n          break;\n        }\n        case 32: { // SPACE; takes priority over ALT\n          if (mode === MODE_HANDLE || mode === MODE_CENTER) {\n            if (signX < 0) e0 = e1 - dx; else if (signX > 0) w0 = w1 - dx;\n            if (signY < 0) s0 = s1 - dy; else if (signY > 0) n0 = n1 - dy;\n            mode = MODE_SPACE;\n            overlay.attr(\"cursor\", cursors.selection);\n            move(event);\n          }\n          break;\n        }\n        default: return;\n      }\n      noevent(event);\n    }\n\n    function keyupped(event) {\n      switch (event.keyCode) {\n        case 16: { // SHIFT\n          if (shifting) {\n            lockX = lockY = shifting = false;\n            move(event);\n          }\n          break;\n        }\n        case 18: { // ALT\n          if (mode === MODE_CENTER) {\n            if (signX < 0) e0 = e1; else if (signX > 0) w0 = w1;\n            if (signY < 0) s0 = s1; else if (signY > 0) n0 = n1;\n            mode = MODE_HANDLE;\n            move(event);\n          }\n          break;\n        }\n        case 32: { // SPACE\n          if (mode === MODE_SPACE) {\n            if (event.altKey) {\n              if (signX) e0 = e1 - dx * signX, w0 = w1 + dx * signX;\n              if (signY) s0 = s1 - dy * signY, n0 = n1 + dy * signY;\n              mode = MODE_CENTER;\n            } else {\n              if (signX < 0) e0 = e1; else if (signX > 0) w0 = w1;\n              if (signY < 0) s0 = s1; else if (signY > 0) n0 = n1;\n              mode = MODE_HANDLE;\n            }\n            overlay.attr(\"cursor\", cursors[type]);\n            move(event);\n          }\n          break;\n        }\n        default: return;\n      }\n      noevent(event);\n    }\n  }\n\n  function touchmoved(event) {\n    emitter(this, arguments).moved(event);\n  }\n\n  function touchended(event) {\n    emitter(this, arguments).ended(event);\n  }\n\n  function initialize() {\n    var state = this.__brush || {selection: null};\n    state.extent = number2(extent.apply(this, arguments));\n    state.dim = dim;\n    return state;\n  }\n\n  brush.extent = function(_) {\n    return arguments.length ? (extent = typeof _ === \"function\" ? _ : constant(number2(_)), brush) : extent;\n  };\n\n  brush.filter = function(_) {\n    return arguments.length ? (filter = typeof _ === \"function\" ? _ : constant(!!_), brush) : filter;\n  };\n\n  brush.touchable = function(_) {\n    return arguments.length ? (touchable = typeof _ === \"function\" ? _ : constant(!!_), brush) : touchable;\n  };\n\n  brush.handleSize = function(_) {\n    return arguments.length ? (handleSize = +_, brush) : handleSize;\n  };\n\n  brush.keyModifiers = function(_) {\n    return arguments.length ? (keys = !!_, brush) : keys;\n  };\n\n  brush.on = function() {\n    var value = listeners.on.apply(listeners, arguments);\n    return value === listeners ? brush : value;\n  };\n\n  return brush;\n}\n","export default function(x) {\n  return Math.abs(x = Math.round(x)) >= 1e21\n      ? x.toLocaleString(\"en\").replace(/,/g, \"\")\n      : x.toString(10);\n}\n\n// Computes the decimal coefficient and exponent of the specified number x with\n// significant digits p, where x is positive and p is in [1, 21] or undefined.\n// For example, formatDecimalParts(1.23) returns [\"123\", 0].\nexport function formatDecimalParts(x, p) {\n  if ((i = (x = p ? x.toExponential(p - 1) : x.toExponential()).indexOf(\"e\")) < 0) return null; // NaN, ±Infinity\n  var i, coefficient = x.slice(0, i);\n\n  // The string returned by toExponential either has the form \\d\\.\\d+e[-+]\\d+\n  // (e.g., 1.2e+3) or the form \\de[-+]\\d+ (e.g., 1e+3).\n  return [\n    coefficient.length > 1 ? coefficient[0] + coefficient.slice(2) : coefficient,\n    +x.slice(i + 1)\n  ];\n}\n","import {formatDecimalParts} from \"./formatDecimal.js\";\n\nexport default function(x) {\n  return x = formatDecimalParts(Math.abs(x)), x ? x[1] : NaN;\n}\n","// [[fill]align][sign][symbol][0][width][,][.precision][~][type]\nvar re = /^(?:(.)?([<>=^]))?([+\\-( ])?([$#])?(0)?(\\d+)?(,)?(\\.\\d+)?(~)?([a-z%])?$/i;\n\nexport default function formatSpecifier(specifier) {\n  if (!(match = re.exec(specifier))) throw new Error(\"invalid format: \" + specifier);\n  var match;\n  return new FormatSpecifier({\n    fill: match[1],\n    align: match[2],\n    sign: match[3],\n    symbol: match[4],\n    zero: match[5],\n    width: match[6],\n    comma: match[7],\n    precision: match[8] && match[8].slice(1),\n    trim: match[9],\n    type: match[10]\n  });\n}\n\nformatSpecifier.prototype = FormatSpecifier.prototype; // instanceof\n\nexport function FormatSpecifier(specifier) {\n  this.fill = specifier.fill === undefined ? \" \" : specifier.fill + \"\";\n  this.align = specifier.align === undefined ? \">\" : specifier.align + \"\";\n  this.sign = specifier.sign === undefined ? \"-\" : specifier.sign + \"\";\n  this.symbol = specifier.symbol === undefined ? \"\" : specifier.symbol + \"\";\n  this.zero = !!specifier.zero;\n  this.width = specifier.width === undefined ? undefined : +specifier.width;\n  this.comma = !!specifier.comma;\n  this.precision = specifier.precision === undefined ? undefined : +specifier.precision;\n  this.trim = !!specifier.trim;\n  this.type = specifier.type === undefined ? \"\" : specifier.type + \"\";\n}\n\nFormatSpecifier.prototype.toString = function() {\n  return this.fill\n      + this.align\n      + this.sign\n      + this.symbol\n      + (this.zero ? \"0\" : \"\")\n      + (this.width === undefined ? \"\" : Math.max(1, this.width | 0))\n      + (this.comma ? \",\" : \"\")\n      + (this.precision === undefined ? \"\" : \".\" + Math.max(0, this.precision | 0))\n      + (this.trim ? \"~\" : \"\")\n      + this.type;\n};\n","import {formatDecimalParts} from \"./formatDecimal.js\";\n\nexport var prefixExponent;\n\nexport default function(x, p) {\n  var d = formatDecimalParts(x, p);\n  if (!d) return x + \"\";\n  var coefficient = d[0],\n      exponent = d[1],\n      i = exponent - (prefixExponent = Math.max(-8, Math.min(8, Math.floor(exponent / 3))) * 3) + 1,\n      n = coefficient.length;\n  return i === n ? coefficient\n      : i > n ? coefficient + new Array(i - n + 1).join(\"0\")\n      : i > 0 ? coefficient.slice(0, i) + \".\" + coefficient.slice(i)\n      : \"0.\" + new Array(1 - i).join(\"0\") + formatDecimalParts(x, Math.max(0, p + i - 1))[0]; // less than 1y!\n}\n","import {formatDecimalParts} from \"./formatDecimal.js\";\n\nexport default function(x, p) {\n  var d = formatDecimalParts(x, p);\n  if (!d) return x + \"\";\n  var coefficient = d[0],\n      exponent = d[1];\n  return exponent < 0 ? \"0.\" + new Array(-exponent).join(\"0\") + coefficient\n      : coefficient.length > exponent + 1 ? coefficient.slice(0, exponent + 1) + \".\" + coefficient.slice(exponent + 1)\n      : coefficient + new Array(exponent - coefficient.length + 2).join(\"0\");\n}\n","import formatDecimal from \"./formatDecimal.js\";\nimport formatPrefixAuto from \"./formatPrefixAuto.js\";\nimport formatRounded from \"./formatRounded.js\";\n\nexport default {\n  \"%\": (x, p) => (x * 100).toFixed(p),\n  \"b\": (x) => Math.round(x).toString(2),\n  \"c\": (x) => x + \"\",\n  \"d\": formatDecimal,\n  \"e\": (x, p) => x.toExponential(p),\n  \"f\": (x, p) => x.toFixed(p),\n  \"g\": (x, p) => x.toPrecision(p),\n  \"o\": (x) => Math.round(x).toString(8),\n  \"p\": (x, p) => formatRounded(x * 100, p),\n  \"r\": formatRounded,\n  \"s\": formatPrefixAuto,\n  \"X\": (x) => Math.round(x).toString(16).toUpperCase(),\n  \"x\": (x) => Math.round(x).toString(16)\n};\n","export default function(x) {\n  return x;\n}\n","import exponent from \"./exponent.js\";\nimport formatGroup from \"./formatGroup.js\";\nimport formatNumerals from \"./formatNumerals.js\";\nimport formatSpecifier from \"./formatSpecifier.js\";\nimport formatTrim from \"./formatTrim.js\";\nimport formatTypes from \"./formatTypes.js\";\nimport {prefixExponent} from \"./formatPrefixAuto.js\";\nimport identity from \"./identity.js\";\n\nvar map = Array.prototype.map,\n    prefixes = [\"y\",\"z\",\"a\",\"f\",\"p\",\"n\",\"µ\",\"m\",\"\",\"k\",\"M\",\"G\",\"T\",\"P\",\"E\",\"Z\",\"Y\"];\n\nexport default function(locale) {\n  var group = locale.grouping === undefined || locale.thousands === undefined ? identity : formatGroup(map.call(locale.grouping, Number), locale.thousands + \"\"),\n      currencyPrefix = locale.currency === undefined ? \"\" : locale.currency[0] + \"\",\n      currencySuffix = locale.currency === undefined ? \"\" : locale.currency[1] + \"\",\n      decimal = locale.decimal === undefined ? \".\" : locale.decimal + \"\",\n      numerals = locale.numerals === undefined ? identity : formatNumerals(map.call(locale.numerals, String)),\n      percent = locale.percent === undefined ? \"%\" : locale.percent + \"\",\n      minus = locale.minus === undefined ? \"−\" : locale.minus + \"\",\n      nan = locale.nan === undefined ? \"NaN\" : locale.nan + \"\";\n\n  function newFormat(specifier) {\n    specifier = formatSpecifier(specifier);\n\n    var fill = specifier.fill,\n        align = specifier.align,\n        sign = specifier.sign,\n        symbol = specifier.symbol,\n        zero = specifier.zero,\n        width = specifier.width,\n        comma = specifier.comma,\n        precision = specifier.precision,\n        trim = specifier.trim,\n        type = specifier.type;\n\n    // The \"n\" type is an alias for \",g\".\n    if (type === \"n\") comma = true, type = \"g\";\n\n    // The \"\" type, and any invalid type, is an alias for \".12~g\".\n    else if (!formatTypes[type]) precision === undefined && (precision = 12), trim = true, type = \"g\";\n\n    // If zero fill is specified, padding goes after sign and before digits.\n    if (zero || (fill === \"0\" && align === \"=\")) zero = true, fill = \"0\", align = \"=\";\n\n    // Compute the prefix and suffix.\n    // For SI-prefix, the suffix is lazily computed.\n    var prefix = symbol === \"$\" ? currencyPrefix : symbol === \"#\" && /[boxX]/.test(type) ? \"0\" + type.toLowerCase() : \"\",\n        suffix = symbol === \"$\" ? currencySuffix : /[%p]/.test(type) ? percent : \"\";\n\n    // What format function should we use?\n    // Is this an integer type?\n    // Can this type generate exponential notation?\n    var formatType = formatTypes[type],\n        maybeSuffix = /[defgprs%]/.test(type);\n\n    // Set the default precision if not specified,\n    // or clamp the specified precision to the supported range.\n    // For significant precision, it must be in [1, 21].\n    // For fixed precision, it must be in [0, 20].\n    precision = precision === undefined ? 6\n        : /[gprs]/.test(type) ? Math.max(1, Math.min(21, precision))\n        : Math.max(0, Math.min(20, precision));\n\n    function format(value) {\n      var valuePrefix = prefix,\n          valueSuffix = suffix,\n          i, n, c;\n\n      if (type === \"c\") {\n        valueSuffix = formatType(value) + valueSuffix;\n        value = \"\";\n      } else {\n        value = +value;\n\n        // Determine the sign. -0 is not less than 0, but 1 / -0 is!\n        var valueNegative = value < 0 || 1 / value < 0;\n\n        // Perform the initial formatting.\n        value = isNaN(value) ? nan : formatType(Math.abs(value), precision);\n\n        // Trim insignificant zeros.\n        if (trim) value = formatTrim(value);\n\n        // If a negative value rounds to zero after formatting, and no explicit positive sign is requested, hide the sign.\n        if (valueNegative && +value === 0 && sign !== \"+\") valueNegative = false;\n\n        // Compute the prefix and suffix.\n        valuePrefix = (valueNegative ? (sign === \"(\" ? sign : minus) : sign === \"-\" || sign === \"(\" ? \"\" : sign) + valuePrefix;\n        valueSuffix = (type === \"s\" ? prefixes[8 + prefixExponent / 3] : \"\") + valueSuffix + (valueNegative && sign === \"(\" ? \")\" : \"\");\n\n        // Break the formatted value into the integer “value” part that can be\n        // grouped, and fractional or exponential “suffix” part that is not.\n        if (maybeSuffix) {\n          i = -1, n = value.length;\n          while (++i < n) {\n            if (c = value.charCodeAt(i), 48 > c || c > 57) {\n              valueSuffix = (c === 46 ? decimal + value.slice(i + 1) : value.slice(i)) + valueSuffix;\n              value = value.slice(0, i);\n              break;\n            }\n          }\n        }\n      }\n\n      // If the fill character is not \"0\", grouping is applied before padding.\n      if (comma && !zero) value = group(value, Infinity);\n\n      // Compute the padding.\n      var length = valuePrefix.length + value.length + valueSuffix.length,\n          padding = length < width ? new Array(width - length + 1).join(fill) : \"\";\n\n      // If the fill character is \"0\", grouping is applied after padding.\n      if (comma && zero) value = group(padding + value, padding.length ? width - valueSuffix.length : Infinity), padding = \"\";\n\n      // Reconstruct the final output based on the desired alignment.\n      switch (align) {\n        case \"<\": value = valuePrefix + value + valueSuffix + padding; break;\n        case \"=\": value = valuePrefix + padding + value + valueSuffix; break;\n        case \"^\": value = padding.slice(0, length = padding.length >> 1) + valuePrefix + value + valueSuffix + padding.slice(length); break;\n        default: value = padding + valuePrefix + value + valueSuffix; break;\n      }\n\n      return numerals(value);\n    }\n\n    format.toString = function() {\n      return specifier + \"\";\n    };\n\n    return format;\n  }\n\n  function formatPrefix(specifier, value) {\n    var f = newFormat((specifier = formatSpecifier(specifier), specifier.type = \"f\", specifier)),\n        e = Math.max(-8, Math.min(8, Math.floor(exponent(value) / 3))) * 3,\n        k = Math.pow(10, -e),\n        prefix = prefixes[8 + e / 3];\n    return function(value) {\n      return f(k * value) + prefix;\n    };\n  }\n\n  return {\n    format: newFormat,\n    formatPrefix: formatPrefix\n  };\n}\n","import formatLocale from \"./locale.js\";\n\nvar locale;\nexport var format;\nexport var formatPrefix;\n\ndefaultLocale({\n  thousands: \",\",\n  grouping: [3],\n  currency: [\"$\", \"\"]\n});\n\nexport default function defaultLocale(definition) {\n  locale = formatLocale(definition);\n  format = locale.format;\n  formatPrefix = locale.formatPrefix;\n  return locale;\n}\n","export default function(grouping, thousands) {\n  return function(value, width) {\n    var i = value.length,\n        t = [],\n        j = 0,\n        g = grouping[0],\n        length = 0;\n\n    while (i > 0 && g > 0) {\n      if (length + g + 1 > width) g = Math.max(1, width - length);\n      t.push(value.substring(i -= g, i + g));\n      if ((length += g + 1) > width) break;\n      g = grouping[j = (j + 1) % grouping.length];\n    }\n\n    return t.reverse().join(thousands);\n  };\n}\n","export default function(numerals) {\n  return function(value) {\n    return value.replace(/[0-9]/g, function(i) {\n      return numerals[+i];\n    });\n  };\n}\n","// Trims insignificant zeros, e.g., replaces 1.2000k with 1.2k.\nexport default function(s) {\n  out: for (var n = s.length, i = 1, i0 = -1, i1; i < n; ++i) {\n    switch (s[i]) {\n      case \".\": i0 = i1 = i; break;\n      case \"0\": if (i0 === 0) i0 = i; i1 = i; break;\n      default: if (!+s[i]) break out; if (i0 > 0) i0 = 0; break;\n    }\n  }\n  return i0 > 0 ? s.slice(0, i0) + s.slice(i1 + 1) : s;\n}\n","import exponent from \"./exponent.js\";\n\nexport default function(step) {\n  return Math.max(0, -exponent(Math.abs(step)));\n}\n","import exponent from \"./exponent.js\";\n\nexport default function(step, value) {\n  return Math.max(0, Math.max(-8, Math.min(8, Math.floor(exponent(value) / 3))) * 3 - exponent(Math.abs(step)));\n}\n","import exponent from \"./exponent.js\";\n\nexport default function(step, max) {\n  step = Math.abs(step), max = Math.abs(max) - step;\n  return Math.max(0, exponent(max) - exponent(step)) + 1;\n}\n","var e10 = Math.sqrt(50),\n    e5 = Math.sqrt(10),\n    e2 = Math.sqrt(2);\n\nexport default function ticks(start, stop, count) {\n  var reverse,\n      i = -1,\n      n,\n      ticks,\n      step;\n\n  stop = +stop, start = +start, count = +count;\n  if (start === stop && count > 0) return [start];\n  if (reverse = stop < start) n = start, start = stop, stop = n;\n  if ((step = tickIncrement(start, stop, count)) === 0 || !isFinite(step)) return [];\n\n  if (step > 0) {\n    let r0 = Math.round(start / step), r1 = Math.round(stop / step);\n    if (r0 * step < start) ++r0;\n    if (r1 * step > stop) --r1;\n    ticks = new Array(n = r1 - r0 + 1);\n    while (++i < n) ticks[i] = (r0 + i) * step;\n  } else {\n    step = -step;\n    let r0 = Math.round(start * step), r1 = Math.round(stop * step);\n    if (r0 / step < start) ++r0;\n    if (r1 / step > stop) --r1;\n    ticks = new Array(n = r1 - r0 + 1);\n    while (++i < n) ticks[i] = (r0 + i) / step;\n  }\n\n  if (reverse) ticks.reverse();\n\n  return ticks;\n}\n\nexport function tickIncrement(start, stop, count) {\n  var step = (stop - start) / Math.max(0, count),\n      power = Math.floor(Math.log(step) / Math.LN10),\n      error = step / Math.pow(10, power);\n  return power >= 0\n      ? (error >= e10 ? 10 : error >= e5 ? 5 : error >= e2 ? 2 : 1) * Math.pow(10, power)\n      : -Math.pow(10, -power) / (error >= e10 ? 10 : error >= e5 ? 5 : error >= e2 ? 2 : 1);\n}\n\nexport function tickStep(start, stop, count) {\n  var step0 = Math.abs(stop - start) / Math.max(0, count),\n      step1 = Math.pow(10, Math.floor(Math.log(step0) / Math.LN10)),\n      error = step0 / step1;\n  if (error >= e10) step1 *= 10;\n  else if (error >= e5) step1 *= 5;\n  else if (error >= e2) step1 *= 2;\n  return stop < start ? -step1 : step1;\n}\n","export default function ascending(a, b) {\n  return a == null || b == null ? NaN : a < b ? -1 : a > b ? 1 : a >= b ? 0 : NaN;\n}\n","export default function descending(a, b) {\n  return a == null || b == null ? NaN\n    : b < a ? -1\n    : b > a ? 1\n    : b >= a ? 0\n    : NaN;\n}\n","import ascending from \"./ascending.js\";\nimport descending from \"./descending.js\";\n\nexport default function bisector(f) {\n  let compare1, compare2, delta;\n\n  // If an accessor is specified, promote it to a comparator. In this case we\n  // can test whether the search value is (self-) comparable. We can’t do this\n  // for a comparator (except for specific, known comparators) because we can’t\n  // tell if the comparator is symmetric, and an asymmetric comparator can’t be\n  // used to test whether a single value is comparable.\n  if (f.length !== 2) {\n    compare1 = ascending;\n    compare2 = (d, x) => ascending(f(d), x);\n    delta = (d, x) => f(d) - x;\n  } else {\n    compare1 = f === ascending || f === descending ? f : zero;\n    compare2 = f;\n    delta = f;\n  }\n\n  function left(a, x, lo = 0, hi = a.length) {\n    if (lo < hi) {\n      if (compare1(x, x) !== 0) return hi;\n      do {\n        const mid = (lo + hi) >>> 1;\n        if (compare2(a[mid], x) < 0) lo = mid + 1;\n        else hi = mid;\n      } while (lo < hi);\n    }\n    return lo;\n  }\n\n  function right(a, x, lo = 0, hi = a.length) {\n    if (lo < hi) {\n      if (compare1(x, x) !== 0) return hi;\n      do {\n        const mid = (lo + hi) >>> 1;\n        if (compare2(a[mid], x) <= 0) lo = mid + 1;\n        else hi = mid;\n      } while (lo < hi);\n    }\n    return lo;\n  }\n\n  function center(a, x, lo = 0, hi = a.length) {\n    const i = left(a, x, lo, hi - 1);\n    return i > lo && delta(a[i - 1], x) > -delta(a[i], x) ? i - 1 : i;\n  }\n\n  return {left, center, right};\n}\n\nfunction zero() {\n  return 0;\n}\n","import ascending from \"./ascending.js\";\nimport bisector from \"./bisector.js\";\nimport number from \"./number.js\";\n\nconst ascendingBisect = bisector(ascending);\nexport const bisectRight = ascendingBisect.right;\nexport const bisectLeft = ascendingBisect.left;\nexport const bisectCenter = bisector(number).center;\nexport default bisectRight;\n","export default function number(x) {\n  return x === null ? NaN : +x;\n}\n\nexport function* numbers(values, valueof) {\n  if (valueof === undefined) {\n    for (let value of values) {\n      if (value != null && (value = +value) >= value) {\n        yield value;\n      }\n    }\n  } else {\n    let index = -1;\n    for (let value of values) {\n      if ((value = valueof(value, ++index, values)) != null && (value = +value) >= value) {\n        yield value;\n      }\n    }\n  }\n}\n","export default function(a, b) {\n  return a = +a, b = +b, function(t) {\n    return Math.round(a * (1 - t) + b * t);\n  };\n}\n","export default function number(x) {\n  return +x;\n}\n","import {bisect} from \"d3-array\";\nimport {interpolate as interpolateValue, interpolateNumber, interpolateRound} from \"d3-interpolate\";\nimport constant from \"./constant.js\";\nimport number from \"./number.js\";\n\nvar unit = [0, 1];\n\nexport function identity(x) {\n  return x;\n}\n\nfunction normalize(a, b) {\n  return (b -= (a = +a))\n      ? function(x) { return (x - a) / b; }\n      : constant(isNaN(b) ? NaN : 0.5);\n}\n\nfunction clamper(a, b) {\n  var t;\n  if (a > b) t = a, a = b, b = t;\n  return function(x) { return Math.max(a, Math.min(b, x)); };\n}\n\n// normalize(a, b)(x) takes a domain value x in [a,b] and returns the corresponding parameter t in [0,1].\n// interpolate(a, b)(t) takes a parameter t in [0,1] and returns the corresponding range value x in [a,b].\nfunction bimap(domain, range, interpolate) {\n  var d0 = domain[0], d1 = domain[1], r0 = range[0], r1 = range[1];\n  if (d1 < d0) d0 = normalize(d1, d0), r0 = interpolate(r1, r0);\n  else d0 = normalize(d0, d1), r0 = interpolate(r0, r1);\n  return function(x) { return r0(d0(x)); };\n}\n\nfunction polymap(domain, range, interpolate) {\n  var j = Math.min(domain.length, range.length) - 1,\n      d = new Array(j),\n      r = new Array(j),\n      i = -1;\n\n  // Reverse descending domains.\n  if (domain[j] < domain[0]) {\n    domain = domain.slice().reverse();\n    range = range.slice().reverse();\n  }\n\n  while (++i < j) {\n    d[i] = normalize(domain[i], domain[i + 1]);\n    r[i] = interpolate(range[i], range[i + 1]);\n  }\n\n  return function(x) {\n    var i = bisect(domain, x, 1, j) - 1;\n    return r[i](d[i](x));\n  };\n}\n\nexport function copy(source, target) {\n  return target\n      .domain(source.domain())\n      .range(source.range())\n      .interpolate(source.interpolate())\n      .clamp(source.clamp())\n      .unknown(source.unknown());\n}\n\nexport function transformer() {\n  var domain = unit,\n      range = unit,\n      interpolate = interpolateValue,\n      transform,\n      untransform,\n      unknown,\n      clamp = identity,\n      piecewise,\n      output,\n      input;\n\n  function rescale() {\n    var n = Math.min(domain.length, range.length);\n    if (clamp !== identity) clamp = clamper(domain[0], domain[n - 1]);\n    piecewise = n > 2 ? polymap : bimap;\n    output = input = null;\n    return scale;\n  }\n\n  function scale(x) {\n    return x == null || isNaN(x = +x) ? unknown : (output || (output = piecewise(domain.map(transform), range, interpolate)))(transform(clamp(x)));\n  }\n\n  scale.invert = function(y) {\n    return clamp(untransform((input || (input = piecewise(range, domain.map(transform), interpolateNumber)))(y)));\n  };\n\n  scale.domain = function(_) {\n    return arguments.length ? (domain = Array.from(_, number), rescale()) : domain.slice();\n  };\n\n  scale.range = function(_) {\n    return arguments.length ? (range = Array.from(_), rescale()) : range.slice();\n  };\n\n  scale.rangeRound = function(_) {\n    return range = Array.from(_), interpolate = interpolateRound, rescale();\n  };\n\n  scale.clamp = function(_) {\n    return arguments.length ? (clamp = _ ? true : identity, rescale()) : clamp !== identity;\n  };\n\n  scale.interpolate = function(_) {\n    return arguments.length ? (interpolate = _, rescale()) : interpolate;\n  };\n\n  scale.unknown = function(_) {\n    return arguments.length ? (unknown = _, scale) : unknown;\n  };\n\n  return function(t, u) {\n    transform = t, untransform = u;\n    return rescale();\n  };\n}\n\nexport default function continuous() {\n  return transformer()(identity, identity);\n}\n","export default function constants(x) {\n  return function() {\n    return x;\n  };\n}\n","export function initRange(domain, range) {\n  switch (arguments.length) {\n    case 0: break;\n    case 1: this.range(domain); break;\n    default: this.range(range).domain(domain); break;\n  }\n  return this;\n}\n\nexport function initInterpolator(domain, interpolator) {\n  switch (arguments.length) {\n    case 0: break;\n    case 1: {\n      if (typeof domain === \"function\") this.interpolator(domain);\n      else this.range(domain);\n      break;\n    }\n    default: {\n      this.domain(domain);\n      if (typeof interpolator === \"function\") this.interpolator(interpolator);\n      else this.range(interpolator);\n      break;\n    }\n  }\n  return this;\n}\n","import {ticks, tickIncrement} from \"d3-array\";\nimport continuous, {copy} from \"./continuous.js\";\nimport {initRange} from \"./init.js\";\nimport tickFormat from \"./tickFormat.js\";\n\nexport function linearish(scale) {\n  var domain = scale.domain;\n\n  scale.ticks = function(count) {\n    var d = domain();\n    return ticks(d[0], d[d.length - 1], count == null ? 10 : count);\n  };\n\n  scale.tickFormat = function(count, specifier) {\n    var d = domain();\n    return tickFormat(d[0], d[d.length - 1], count == null ? 10 : count, specifier);\n  };\n\n  scale.nice = function(count) {\n    if (count == null) count = 10;\n\n    var d = domain();\n    var i0 = 0;\n    var i1 = d.length - 1;\n    var start = d[i0];\n    var stop = d[i1];\n    var prestep;\n    var step;\n    var maxIter = 10;\n\n    if (stop < start) {\n      step = start, start = stop, stop = step;\n      step = i0, i0 = i1, i1 = step;\n    }\n    \n    while (maxIter-- > 0) {\n      step = tickIncrement(start, stop, count);\n      if (step === prestep) {\n        d[i0] = start\n        d[i1] = stop\n        return domain(d);\n      } else if (step > 0) {\n        start = Math.floor(start / step) * step;\n        stop = Math.ceil(stop / step) * step;\n      } else if (step < 0) {\n        start = Math.ceil(start * step) / step;\n        stop = Math.floor(stop * step) / step;\n      } else {\n        break;\n      }\n      prestep = step;\n    }\n\n    return scale;\n  };\n\n  return scale;\n}\n\nexport default function linear() {\n  var scale = continuous();\n\n  scale.copy = function() {\n    return copy(scale, linear());\n  };\n\n  initRange.apply(scale, arguments);\n\n  return linearish(scale);\n}\n","import {tickStep} from \"d3-array\";\nimport {format, formatPrefix, formatSpecifier, precisionFixed, precisionPrefix, precisionRound} from \"d3-format\";\n\nexport default function tickFormat(start, stop, count, specifier) {\n  var step = tickStep(start, stop, count),\n      precision;\n  specifier = formatSpecifier(specifier == null ? \",f\" : specifier);\n  switch (specifier.type) {\n    case \"s\": {\n      var value = Math.max(Math.abs(start), Math.abs(stop));\n      if (specifier.precision == null && !isNaN(precision = precisionPrefix(step, value))) specifier.precision = precision;\n      return formatPrefix(specifier, value);\n    }\n    case \"\":\n    case \"e\":\n    case \"g\":\n    case \"p\":\n    case \"r\": {\n      if (specifier.precision == null && !isNaN(precision = precisionRound(step, Math.max(Math.abs(start), Math.abs(stop))))) specifier.precision = precision - (specifier.type === \"e\");\n      break;\n    }\n    case \"f\":\n    case \"%\": {\n      if (specifier.precision == null && !isNaN(precision = precisionFixed(step))) specifier.precision = precision - (specifier.type === \"%\") * 2;\n      break;\n    }\n  }\n  return format(specifier);\n}\n","var organismMetadata = {\n  9606: {\n    commonName: 'Human',\n    scientificName: 'Homo sapiens',\n    assemblies: {\n      default: 'GCF_000001405.26', // GRCh38\n      GRCh38: 'GCF_000001405.26',\n      GRCh37: 'GCF_000001405.13',\n      NCBI36: 'GCF_000001405.12'\n    },\n    hasGeneCache: true,\n    hasParalogCache: true,\n    hasInteractionCache: true,\n    hasGeneStructureCache: true\n  },\n  10090: {\n    commonName: 'Mouse',\n    scientificName: 'Mus musculus',\n    assemblies: {\n      default: 'GCF_000001635.20', // GRCm38\n      GRCm38: 'GCF_000001635.20',\n      MGSCv37: 'GCF_000001635.18'\n    },\n    hasGeneCache: true,\n    hasParalogCache: true,\n    hasInteractionCache: true\n  },\n  9598: {\n    commonName: 'Chimpanzee',\n    scientificName: 'Pan troglodytes',\n    assemblies: {\n      'default': 'GCF_000001515.7',\n      'Pan_tro 3.0': 'GCF_000001515.7'\n    },\n    hasGeneCache: true,\n    hasParalogCache: true\n  },\n  10116: {\n    commonName: 'Rat',\n    scientificName: 'Rattus norvegicus',\n    assemblies: {\n      'default': 'GCF_000001895.5',\n      'Rnor_6.0': 'GCF_000001895.5'\n    },\n    hasGeneCache: true,\n    hasParalogCache: true\n  },\n  3702: {\n    commonName: 'Thale cress',\n    scientificName: 'Arabidopsis thaliana',\n    assemblies: {\n      default: 'GCF_000001735.3', // TAIR10\n      TAIR10: 'GCF_000001735.3'\n    }\n  },\n  4530: {\n    commonName: 'Rice',\n    scientificName: 'Oryza sativa',\n    assemblies: {\n      'default': 'GCA_001433935.1',\n      'IRGSP-1.0': 'GCA_001433935.1'\n    }\n  },\n  4577: {\n    commonName: 'Maize',\n    scientificName: 'Zea mays',\n    assemblies: {\n      'default': 'GCA_000005005.5',\n      'IRGSP-1.0': 'GCA_001433935.1'\n    }\n  },\n  4641: {\n    commonName: 'Banana',\n    scientificName: 'Musa acuminata',\n    assemblies: {\n      default: 'mock'\n    }\n  },\n  7227: {\n    commonName: 'Fly',\n    scientificName: 'Drosophila melanogaster',\n    assemblies: {\n      'default': 'GCA_000001215.4',\n      'Release 6 plus ISO1 MT': 'GCA_000001215.4'\n    }\n  },\n  7165: {\n    commonName: 'Mosquito',\n    scientificName: 'Anopheles gambiae',\n    assemblies: {\n      default: 'GCF_000005575.2'\n    }\n  },\n  746128: {\n    commonName: 'Aspergillis fumigatus',\n    scientificName: 'Aspergillis fumigatus',\n    assemblies: {\n      default: 'GCF_000002655.1'\n    }\n  },\n  227321: {\n    scientificName: 'Aspergillus nidulans',\n    assemblies: {\n      default: 'GCF_000149205.2'\n    }\n  },\n  5061: {\n    commonName: 'black mold',\n    scientificName: 'Aspergillus niger',\n    assemblies: {\n      default: 'GCF_003184595.1'\n    }\n  },\n  5062: {\n    commonName: 'koji',\n    scientificName: 'Aspergillus oryzae',\n    assemblies: {\n      default: 'GCF_000184455.2'\n    }\n  },\n  15368: {\n    commonName: 'stiff brome',\n    scientificName: 'Brachypodium distachyon',\n    assemblies: {\n      default: 'GCF_000005505.3'\n    }\n  },\n  60711: {\n    commonName: 'green monkey',\n    scientificName: 'Chlorocebus sabaeus',\n    assemblies: {\n      default: 'GCF_015252025.1'\n    }\n  },\n  7719: {\n    commonName: 'Vase tunicate',\n    scientificName: 'Ciona intestinalis',\n    assemblies: {\n      default: 'GCF_000224145.3'\n    }\n  },\n  9685: {\n    commonName: 'Cat',\n    scientificName: 'Felis catus',\n    assemblies: {\n      default: 'GCF_000181335.3'\n    },\n    hasGeneCache: true\n  },\n  9031: {\n    commonName: 'Chicken',\n    scientificName: 'Gallus gallus',\n    assemblies: {\n      default: 'GCF_000002315.6'\n    },\n    hasGeneCache: true,\n    hasParalogCache: true\n  },\n  9593: {\n    commonName: 'Gorilla',\n    scientificName: 'Gorilla gorilla',\n    assemblies: {\n      default: 'GCF_008122165.1'\n    }\n  },\n  4513: {\n    commonName: 'Barley',\n    scientificName: 'Hordeum vulgare',\n    assemblies: {\n      default: 'GCA_901482405.1'\n    }\n  },\n  9541: {\n    commonName: 'Crab-eating macaque',\n    scientificName: 'Macaca fascicularis',\n    assemblies: {\n      default: 'GCF_000364345.1'\n    },\n    hasGeneCache: true,\n    hasParalogCache: true\n  },\n  9544: {\n    commonName: 'Rhesus macaque',\n    scientificName: 'Macaca mulatta',\n    assemblies: {\n      default: 'GCF_003339765.1'\n    },\n    hasGeneCache: true,\n    hasParalogCache: true\n  },\n  9597: {\n    commonName: 'Bonobo',\n    scientificName: 'Pan paniscus',\n    assemblies: {\n      default: 'GCF_013052645.1'\n    }\n  },\n  9615: {\n    commonName: 'Dog',\n    scientificName: 'Canis lupus familiaris',\n    assemblies: {\n      default: 'GCF_014441545.1'\n    },\n    hasGeneCache: true,\n    hasParalogCache: true\n  },\n  4932: {\n    commonName: 'Yeast',\n    scientificName: 'Saccharomyces cerevisiae',\n    assemblies: {\n      default: 'GCA_000146045.2',\n      R64: 'GCA_000146045.2'\n    }\n  },\n  5833: {\n    commonName: 'malaria parasite',\n    scientificName: 'Plasmodium falciparum',\n    assemblies: {\n      default: 'GCA_000002765.3',\n      GCA_000002765: 'GCA_000002765.3'\n    }\n  },\n  6239: {\n    commonName: 'worm',\n    scientificName: 'Caenorhabditis elegans',\n    assemblies: {\n      default: 'GCF_000002985.6'\n    },\n    hasGeneCache: true,\n    hasParalogCache: true\n  },\n  4081: {\n    commonName: 'tomato',\n    scientificName: 'Solanum lycopersicum',\n    assemblies: {\n      default: 'GCF_000188115.4'\n    }\n  },\n  4072: {\n    commonName: 'pepper',\n    scientificName: 'Capsicum annuum',\n    assemblies: {\n      default: 'GCF_000710875.1'\n    }\n  }\n};\n\nexport {organismMetadata};\n","var staticColors, staticCss, staticGradients;\n\n// Gradient colors for each class, for polished rendering\nstaticColors = [\n  ['gneg', '#FFF', '#FFF', '#DDD'],\n  ['gpos25', '#C8C8C8', '#DDD', '#BBB'],\n  ['gpos33', '#BBB', '#BBB', '#AAA'],\n  ['gpos50', '#999', '#AAA', '#888'],\n  ['gpos66', '#888', '#888', '#666'],\n  ['gpos75', '#777', '#777', '#444'],\n  ['gpos100', '#444', '#666', '#000'],\n  ['acen', '#FEE', '#FEE', '#FDD'],\n  ['noBands', '#BBB', '#BBB', '#AAA']\n];\n\nstaticCss =\n  '#_ideogram {padding-left: 5px;} ' +\n  '#_ideogram .labeled {padding-left: 15px;} ' +\n  '#_ideogram.labeledLeft {padding-left: 15px; padding-top: 15px;} ' +\n  // Tahoma has great readability and space utilization at small sizes\n  // More: http://ux.stackexchange.com/a/3334\n  '#_ideogram text {font: 9px Tahoma; fill: #000;} ' +\n  '#_ideogram .italic {font-style: italic;} ' +\n  '#_ideogram .chromosome {cursor: pointer; fill: #AAA;}' +\n  '#_ideogram.no-rotate .chromosome {cursor: default;} ' +\n  '#_ideogram .chrLabel, #_ideogram .annot {cursor: pointer;}' +\n  '#_ideogram .chrSetLabel {font-weight: bolder;}' +\n  '#_ideogram .ghost {opacity: 0.2;}' +\n  '#_ideogram .hidden {display: none;}' +\n  '#_ideogram .bandLabelStalk line {stroke: #AAA; stroke-width: 1;}' +\n  '#_ideogram .syntenyBorder {stroke:#AAA;stroke-width:1;}' +\n  '#_ideogram rect.cursor {' +\n  '  fill: #F00;' +\n  '  stroke: #F00;' +\n  '  fill-opacity: .3;' +\n  '  shape-rendering: crispEdges;' +\n  '}' +\n  '#_ideogram .brush .selection {' +\n  '  fill: #F00;' +\n  '  stroke: #F00;' +\n  '  fill-opacity: .3;' +\n  '  shape-rendering: crispEdges;' +\n  '}' +\n  '#_ideogram .noBands {fill: #AAA;}' +\n  // NCBI stain density colors\n  '#_ideogram .gneg {fill: #FFF}' +\n  '#_ideogram .gpos25 {fill: #BBB}' +\n  '#_ideogram .gpos33 {fill: #AAA}' +\n  '#_ideogram .gpos50 {fill: #888}' +\n  '#_ideogram .gpos66 {fill: #666}' +\n  '#_ideogram .gpos75 {fill: #444}' +\n  '#_ideogram .gpos100 {fill: #000}' +\n  '#_ideogram .gpos {fill: #000}' +\n  '#_ideogram .acen {fill: #FDD}' +\n  '#_ideogram .stalk {fill: #CCE;}' +\n  '#_ideogram .gvar {fill: #DDF}' +\n  // Used when overlaid with annotations\n  '#_ideogram.faint .gneg {fill: #FFF}' +\n  '#_ideogram.faint .gpos25 {fill: #EEE}' +\n  '#_ideogram.faint .gpos33 {fill: #EEE}' +\n  '#_ideogram.faint .gpos50 {fill: #EEE}' +\n  '#_ideogram.faint .gpos66 {fill: #EEE}' +\n  '#_ideogram.faint .gpos75 {fill: #EEE}' +\n  '#_ideogram.faint .gpos100 {fill: #DDD}' +\n  '#_ideogram.faint .gpos {fill: #DDD}' +\n  '#_ideogram.faint .acen {fill: #FEE}' +\n  '#_ideogram.faint .stalk {fill: #EEF;}' +\n  '#_ideogram.faint .gvar {fill: #EEF}' +\n  // For sheen, i.e. the soft shine in chromosomes\n  '#_ideogram .gneg {fill: url(\"#gneg\")} ' +\n  '#_ideogram .gpos25 {fill: url(\"#gpos25\")} ' +\n  '#_ideogram .gpos33 {fill: url(\"#gpos33\")} ' +\n  '#_ideogram .gpos50 {fill: url(\"#gpos50\")} ' +\n  '#_ideogram .gpos66 {fill: url(\"#gpos66\")} ' +\n  '#_ideogram .gpos75 {fill: url(\"#gpos75\")} ' +\n  '#_ideogram .gpos100 {fill: url(\"#gpos100\")} ' +\n  '#_ideogram .gpos {fill: url(\"#gpos100\")} ' +\n  '#_ideogram .acen {fill: url(\"#acen\")} ' +\n  '#_ideogram .stalk {fill: url(\"#stalk\")} ' +\n  '#_ideogram .gvar {fill: url(\"#gvar\")} ' +\n  '#_ideogram .noBands {fill: url(\"#noBands\")} ' +\n  '#_ideogram .chromosome {fill: url(\"#noBands\")} ';\n\nstaticGradients =\n  '<pattern id=\"stalk\" width=\"2\" height=\"1\" patternUnits=\"userSpaceOnUse\" ' +\n  'patternTransform=\"rotate(30 0 0)\">' +\n  '<rect x=\"0\" y=\"0\" width=\"10\" height=\"2\" fill=\"#CCE\" /> ' +\n  '<line x1=\"0\" y1=\"0\" x2=\"0\" y2=\"100%\" style=\"stroke:#88B; ' +\n  'stroke-width:0.7;\" />' +\n  '</pattern>' +\n  '<pattern id=\"gvar\" width=\"2\" height=\"1\" patternUnits=\"userSpaceOnUse\" ' +\n  'patternTransform=\"rotate(-30 0 0)\">' +\n  '<rect x=\"0\" y=\"0\" width=\"10\" height=\"2\" fill=\"#DDF\" /> ' +\n  '<line x1=\"0\" y1=\"0\" x2=\"0\" y2=\"100%\" style=\"stroke:#99C; ' +\n  'stroke-width:0.7;\" />' +\n  '</pattern>';\n\nexport {staticColors, staticCss, staticGradients};\n","/**\n * @fileoverview A collection of Ideogram methods that don't fit elsewhere.\n */\n\nimport {select, selectAll} from 'd3-selection';\nimport * as d3fetch from 'd3-fetch';\nimport * as d3brush from 'd3-brush';\nimport * as d3dispatch from 'd3-dispatch';\nimport * as d3format from 'd3-format';\nimport {scaleLinear} from 'd3-scale';\nimport {max} from 'd3-array';\n\nimport {organismMetadata} from './init/organism-metadata';\n\nvar d3 = Object.assign(\n  {}, d3fetch, d3brush, d3dispatch, d3format\n);\n\nd3.select = select;\nd3.selectAll = selectAll;\nd3.scaleLinear = scaleLinear;\nd3.max = max;\n\n/**\n * Is the assembly in this.config an NCBI Assembly accession?\n *\n * @returns {boolean}\n */\nfunction assemblyIsAccession() {\n  return (\n    'assembly' in this.config &&\n    /(GCF_|GCA_)/.test(this.config.assembly)\n  );\n}\n\n/**\n * Is the assembly in this.config not from GenBank?\n *\n * @returns {boolean}\n */\nfunction hasNonGenBankAssembly(ideo) {\n  return (\n    'assembly' in ideo.config &&\n    /(GCA_)/.test(ideo.config.assembly) === false\n  );\n}\n\n/**\n * Is the assembly in this.config from GenBank?\n *\n * @returns {boolean}\n */\nfunction hasGenBankAssembly(ideo) {\n  return (\n    'assembly' in ideo.config &&\n    /(GCA_)/.test(ideo.config.assembly)\n  );\n}\n\nfunction getDir(dir) {\n  var script, tmp, protocol, dataDir, ideogramInLeaf,\n    scripts = document.scripts,\n    version = Ideogram.version;\n\n  if (location.pathname.includes('/examples/vanilla/') === false) {\n    return (\n      `https://cdn.jsdelivr.net/npm/ideogram@${version}/dist/data/${dir}`\n    );\n  }\n\n  for (var i = 0; i < scripts.length; i++) {\n    script = scripts[i];\n    ideogramInLeaf = /ideogram/.test(script.src.split('/').slice(-1));\n    if ('src' in script && ideogramInLeaf) {\n      tmp = script.src.split('//');\n      protocol = tmp[0];\n      tmp = '/' + tmp[1].split('/').slice(0, -2).join('/');\n      dataDir = protocol + '//' + tmp + '/data/' + dir;\n      return dataDir;\n    }\n  }\n\n  return '../data/' + dir;\n}\n\n/** Try request, and if failed then retry with URL lacking extension */\nfunction fetchWithRetry(url, isRetry=false) {\n  return fetch(url)\n    .then((response) => {\n      if (response.ok) {\n        return response;\n      } else {\n        if (isRetry === false) {\n          var urlWithoutExtension = url.replace('.json', '');\n          return fetchWithRetry(urlWithoutExtension, true);\n        } else {\n          throw Error('Fetch failed for ' + url);\n        }\n      }\n    });\n}\n\n/**\n * Returns directory used to fetch data for bands and annotations\n *\n * This simplifies ideogram configuration.  By default, the dataDir is\n * set to an external CDN unless we're serving from the local Ideogram\n * working directory\n *\n * @returns {String}\n */\nfunction getDataDir() {\n  return getDir('bands/native/');\n}\n\n/**\n * Rounds a float (e.g. SVG coordinate) to two decimal places\n *\n * @param coord Floating-point number, e.g. 42.1234567890\n * @returns {number} Rounded value, e.g. 42.12\n */\nfunction round(coord) {\n  // Per http://stackoverflow.com/a/9453447, below method is fastest\n  return Math.round(coord * 100) / 100;\n}\n\n/**\n * Convert e.g. 1000 to 1 k, 1500000 to 1.5 M, etc.\n * Used to format 1500000 base pairs to e.g. 1.5 Mbp\n *\n * Adapted from https://stackoverflow.com/a/9462382/10564415\n */\nfunction formatSiPrefix(num, digits) {\n  const lookup = [\n    {value: 1, symbol: ''},\n    {value: 1e3, symbol: 'k'},\n    {value: 1e6, symbol: 'M'},\n    {value: 1e9, symbol: 'G'},\n    {value: 1e12, symbol: 'T'},\n    {value: 1e15, symbol: 'P'},\n    {value: 1e18, symbol: 'E'}\n  ];\n  const rx = /\\.0+$|(\\.[0-9]*[1-9])0+$/;\n  var item = lookup.slice().reverse().find(function(item) {\n    return num >= item.value;\n  });\n  // eslint-disable-next-line max-len\n  return item ? (num / item.value).toFixed(digits).replace(rx, '$1') + ' ' + item.symbol : '0';\n}\n\nfunction onDidRotate(chrModel) {\n  call(this.onDidRotateCallback, chrModel);\n}\n\n/**\n * Get ideogram SVG container\n */\nfunction getSvg() {\n  return d3.select(this.selector).node();\n}\n\n/** Request data with Ideogram's authorization bearer token */\nfunction fetchWithAuth(url, contentType) {\n  var ideo = this,\n    config = ideo.config,\n    headers = new Headers();\n\n  if (config.accessToken) {\n    headers = new Headers({Authorization: 'Bearer ' + config.accessToken});\n  }\n\n  if (contentType === 'text') {\n    return d3.text(url, {headers: headers});\n  } else {\n    return d3.json(url, {headers: headers});\n  }\n}\n\n/** getTaxid(), but without need to initialize ideogram  */\nfunction getEarlyTaxid(name) {\n  name = slug(name);\n  for (const taxid in organismMetadata) {\n    const organism = organismMetadata[taxid];\n    const commonName = slug(organism.commonName);\n    const scientificName = slug(organism.scientificName);\n    if (commonName === name || scientificName === name) {\n      return taxid;\n    }\n  }\n\n  return null;\n}\n\n/**\n * Get organism's taxid (NCBI Taxonomy ID) given its common or scientific name\n */\nfunction getTaxid(name) {\n  var organism, taxid, commonName, scientificName,\n    ideo = this,\n    organisms = ideo.organisms;\n\n  name = slug(name);\n\n  for (taxid in organisms) {\n    organism = organisms[taxid];\n    commonName = slug(organism.commonName);\n    scientificName = slug(organism.scientificName);\n    if (commonName === name || scientificName === name) {\n      return taxid;\n    }\n  }\n\n  return null;\n}\n\n/**\n * Get organism's common name given its taxid\n */\nfunction getCommonName(taxid) {\n  var ideo = this;\n  if (taxid in ideo.organisms) {\n    return ideo.organisms[taxid].commonName;\n  }\n  return null;\n}\n\n/**\n * Get organism's scientific name given its taxid\n */\nfunction getScientificName(taxid) {\n  var ideo = this;\n  if (taxid in ideo.organisms) {\n    return ideo.organisms[taxid].scientificName;\n  }\n  return null;\n}\n\n/** Convert string to camelcase */\nexport function camel(str) {\n  const camelCaseString = str\n    .split(/[ _-]/g)\n    .map((token, i) => {\n      if (i > 0) {\n        return token[0].toUpperCase() + token.slice(1);\n      } else {\n        return token;\n      }\n    })\n    .join('');\n\n  return camelCaseString;\n}\n\n/**\n* Examples:\n* \"Homo sapiens\" -> \"homo-sapiens\"\n* \"Canis lupus familiaris\" -> \"canis-lupus-familiaris\"\n*/\nfunction slug(value) {\n  if (typeof value === 'undefined') return '';\n  return value.toLowerCase().replace(/ /g, '-');\n}\n\n// Determine if a string is a Roman numeral\n// From https://stackoverflow.com/a/48601418\nfunction isRoman(s) {\n  // http://stackoverflow.com/a/267405/1447675\n  return /^M{0,4}(CM|CD|D?C{0,3})(XC|XL|L?X{0,3})(IX|IV|V?I{0,3})$/i.test(s);\n}\n\n// Convert Roman numeral to integer\n// From https://stackoverflow.com/a/48601418\nfunction parseRoman(s) {\n  var val = {M: 1000, D: 500, C: 100, L: 50, X: 10, V: 5, I: 1};\n  return s.toUpperCase().split('').reduce(function(r, a, i, aa) {\n    return val[a] < val[aa[i + 1]] ? r - val[a] : r + val[a];\n  }, 0);\n}\n\n/**\n* Download a PNG image of the ideogram\n*\n* Includes any annotations, but not legend.\n*/\nfunction downloadPng(ideo) {\n  var ideoSvg = document.querySelector(ideo.selector);\n\n  // Create a hidden canvas.  This will contain the raster image to download.\n  var canvas = document.createElement('canvas');\n  var canvasId = '_ideo-undisplayed-dl-canvas';\n  canvas.setAttribute('style', 'display: none');\n  canvas.setAttribute('id', canvasId);\n  var width = ideoSvg.width.baseVal.value + 30;\n  var ideoSvgClone = ideoSvg.cloneNode(true);\n  ideoSvgClone.style.left = '';\n  canvas.setAttribute('width', width);\n  document.body.appendChild(canvas);\n\n  // Called after PNG image is created from data URL\n  function triggerDownload(imgUrl) {\n    var evt = new MouseEvent('click', {\n      view: window,\n      bubbles: false,\n      cancelable: true\n    });\n\n    var a = document.createElement('a');\n    a.setAttribute('download', 'ideogram.png');\n    a.setAttribute('href', imgUrl);\n    a.setAttribute('target', '_blank');\n\n    // Enables easy testing\n    a.setAttribute('id', '_ideo-undisplayed-dl-image-link');\n    a.setAttribute('style', 'display: none;');\n    document.body.appendChild(a);\n\n    a.dispatchEvent(evt);\n    canvas.remove();\n  }\n\n  var canvas = document.getElementById(canvasId);\n\n  // Enlarge canvas and disable smoothing, for higher resolution PNG\n  canvas.width *= 2;\n  canvas.height *= 2;\n  var ctx = canvas.getContext('2d');\n  ctx.setTransform(2, 0, 0, 2, 0, 0);\n  ctx.imageSmoothingEnabled = false;\n\n  var data = (new XMLSerializer()).serializeToString(ideoSvgClone);\n  var domUrl = window.URL || window.webkitURL || window;\n\n  var img = new Image();\n  var svgBlob = new Blob([data], {type: 'image/svg+xml;charset=utf-8'});\n  var url = domUrl.createObjectURL(svgBlob);\n\n  img.onload = function() {\n    ctx.drawImage(img, 0, 0);\n    domUrl.revokeObjectURL(url);\n\n    var imgUrl = canvas\n      .toDataURL('image/png')\n      .replace('image/png', 'image/octet-stream');\n\n    triggerDownload(imgUrl);\n  };\n\n  img.src = url;\n}\n\n\nfunction getFont(ideo) {\n  const config = ideo.config;\n\n  let family = 'sans-serif';\n  if (config.fontFamily) {\n    family = config.fontFamily;\n  }\n\n  const labelSize = config.annotLabelSize ? config.annotLabelSize : 13;\n  const font = '600 ' + labelSize + 'px ' + family;\n\n  return font;\n}\n\n/**\n * Get width and height of given text in pixels.\n *\n * Background: https://erikonarheim.com/posts/canvas-text-metrics/\n */\nfunction getTextSize(text, ideo) {\n  var font = getFont(ideo);\n\n  // re-use canvas object for better performance\n  var canvas =\n    getTextSize.canvas ||\n    (getTextSize.canvas = document.createElement('canvas'));\n  var context = canvas.getContext('2d');\n  context.font = font;\n  var metrics = context.measureText(text);\n\n  // metrics.width is less precise than technique below\n  var right = metrics.actualBoundingBoxRight;\n  var left = metrics.actualBoundingBoxLeft;\n  var width = Math.abs(left) + Math.abs(right);\n\n  const height =\n    Math.abs(metrics.actualBoundingBoxAscent) +\n    Math.abs(metrics.actualBoundingBoxDescent);\n\n  return {width, height};\n}\n\n/** Clone a nested array */\nfunction deepCopy(array) {\n  return JSON.parse(JSON.stringify(array));\n}\n\nexport {\n  assemblyIsAccession, hasNonGenBankAssembly, hasGenBankAssembly, getDataDir,\n  getDir, round, formatSiPrefix, onDidRotate, getSvg, d3, getEarlyTaxid,\n  getTaxid, getCommonName, getScientificName, slug, isRoman, parseRoman,\n  downloadPng, fetchWithRetry, getTextSize, getFont, deepCopy,\n  fetchWithAuth as fetch\n};\n","import array from \"./array.js\";\nimport {Selection, root} from \"./selection/index.js\";\n\nexport default function(selector) {\n  return typeof selector === \"string\"\n      ? new Selection([document.querySelectorAll(selector)], [document.documentElement])\n      : new Selection([selector == null ? [] : array(selector)], root);\n}\n","export default function max(values, valueof) {\n  let max;\n  if (valueof === undefined) {\n    for (const value of values) {\n      if (value != null\n          && (max < value || (max === undefined && value >= value))) {\n        max = value;\n      }\n    }\n  } else {\n    let index = -1;\n    for (let value of values) {\n      if ((value = valueof(value, ++index, values)) != null\n          && (max < value || (max === undefined && value >= value))) {\n        max = value;\n      }\n    }\n  }\n  return max;\n}\n","import {organismMetadata} from './organism-metadata';\nimport {staticCss} from './../bands/styles';\n\nfunction configurePloidy(ideo) {\n  if (!ideo.config.ploidy) ideo.config.ploidy = 1;\n\n  if (ideo.config.ploidy > 1) {\n    ideo.sexChromosomes = {};\n    if (!ideo.config.sex) {\n      // Default to 'male' per human, mouse reference genomes.\n      // TODO: The default sex value should probably be the heterogametic sex,\n      // i.e. whichever sex has allosomes that differ in morphology.\n      // In mammals and most insects that is the male.\n      // However, in birds and reptiles, that is female.\n      ideo.config.sex = 'male';\n    }\n    if (ideo.config.ploidy === 2 && !ideo.config.ancestors) {\n      ideo.config.ancestors = {M: '#ffb6c1', P: '#add8e6'};\n      ideo.config.ploidyDesc = 'MP';\n    }\n  }\n}\n\nfunction configureHeight(ideo) {\n  var container, rect, chrHeight;\n\n  if (!ideo.config.chrHeight) {\n    container = ideo.config.container;\n    rect = document.querySelector(container).getBoundingClientRect();\n\n    if (ideo.config.orientation === 'vertical') {\n      chrHeight = rect.height;\n    } else {\n      chrHeight = rect.width;\n    }\n\n    if (container === 'body' || chrHeight === 0) chrHeight = 400;\n    ideo.config.chrHeight = chrHeight;\n  }\n}\n\nfunction configureWidth(ideo) {\n  var chrWidth, chrHeight;\n\n  if (!ideo.config.chrWidth) {\n    chrWidth = 10;\n    chrHeight = ideo.config.chrHeight;\n\n    if (chrHeight < 900 && chrHeight > 500) {\n      chrWidth = Math.round(chrHeight / 40);\n    } else if (chrHeight >= 900) {\n      chrWidth = Math.round(chrHeight / 45);\n    }\n    ideo.config.chrWidth = chrWidth;\n  }\n}\n\nfunction configureMargin(ideo) {\n  if (ideo.config.geometry && ideo.config.geometry === 'collinear') {\n    if ('chrMargin' in ideo.config === false) {\n      ideo.config.chrMargin = 0;\n    }\n    return;\n  }\n  if (!ideo.config.chrMargin) {\n    if (ideo.config.ploidy === 1) {\n      ideo.config.chrMargin = 10;\n    } else {\n      // Defaults polyploid chromosomes to relatively small interchromatid gap\n      ideo.config.chrMargin = Math.round(ideo.config.chrWidth / 4);\n    }\n  }\n  if (ideo.config.showBandLabels) ideo.config.chrMargin += 20;\n}\n\nfunction configureBump(ideo) {\n  ideo.bump = Math.round(ideo.config.chrHeight / 125);\n  ideo.adjustedBump = false;\n  if (ideo.config.chrHeight < 200) {\n    ideo.adjustedBump = true;\n    ideo.bump = 4;\n  }\n}\n\nfunction configureSingleChromosome(config, ideo) {\n  if (config.chromosome) {\n    ideo.config.chromosomes = [config.chromosome];\n    if ('showBandLabels' in config === false) {\n      ideo.config.showBandLabels = true;\n    }\n    if ('rotatable' in config === false) ideo.config.rotatable = false;\n  }\n}\n\nfunction configureOrganisms(config, ideo) {\n  ideo.organisms = Object.assign({}, organismMetadata);\n  if (config.taxid && config.organismMetadata) ideo.organisms[config.taxid] = config.organismMetadata\n  ideo.organismsWithBands = Object.assign({}, ideo.organisms);\n}\n\nfunction configureCallbacks(config, ideo) {\n  if (config.onLoad) ideo.onLoadCallback = config.onLoad;\n  if (config.onLoadAnnots) ideo.onLoadAnnotsCallback = config.onLoadAnnots;\n  if (config.onDrawAnnots) ideo.onDrawAnnotsCallback = config.onDrawAnnots;\n  if (config.onBrushMove) ideo.onBrushMoveCallback = config.onBrushMove;\n  if (config.onBrushEnd) ideo.onBrushEndCallback = config.onBrushEnd;\n  if (config.onCursorMove) ideo.onCursorMoveCallback = config.onCursorMove;\n  if (config.onDidRotate) ideo.onDidRotateCallback = config.onDidRotate;\n  if (config.onWillShowAnnotTooltip) {\n    ideo.onWillShowAnnotTooltipCallback = config.onWillShowAnnotTooltip;\n  }\n  if (config.onDidShowAnnotTooltip) {\n    ideo.onDidShowAnnotTooltipCallback = config.onDidShowAnnotTooltip;\n  }\n  if (config.onClickAnnot) {\n    ideo.onClickAnnotCallback = config.onClickAnnot;\n  }\n}\n\nfunction configureMiscellaneous(ideo) {\n  ideo.chromosomesArray = [];\n  ideo.coordinateSystem = 'iscn';\n  ideo.maxLength = {bp: 0, iscn: 0};\n  ideo.chromosomes = {};\n  ideo.numChromosomes = 0;\n  if (!ideo.config.debug) ideo.config.debug = false;\n  if (!ideo.config.dataDir) ideo.config.dataDir = ideo.getDataDir();\n  if (!ideo.config.container) ideo.config.container = 'body';\n  ideo.selector = ideo.config.container + ' #_ideogram';\n  if (!ideo.config.resolution) ideo.config.resolution = '';\n  if (!ideo.config.orientation) ideo.config.orientation = 'vertical';\n  if (!ideo.config.brush) ideo.config.brush = null;\n  if (!ideo.config.rows) ideo.config.rows = 1;\n  if ('showChromosomeLabels' in ideo.config === false) {\n    ideo.config.showChromosomeLabels = true;\n  }\n  if (!ideo.config.showNonNuclearChromosomes) {\n    ideo.config.showNonNuclearChromosomes = false;\n  }\n  if (!ideo.config.chromosomeScale) {\n    ideo.config.chromosomeScale = 'absolute';\n  }\n  if (!ideo.config.showTools) ideo.config.showTools = false;\n}\n\nfunction configureBands(ideo) {\n  if (!ideo.config.showBandLabels) ideo.config.showBandLabels = false;\n\n  if ('showFullyBanded' in ideo.config === false) {\n    ideo.config.showFullyBanded = true;\n  }\n\n  ideo.bandsToShow = [];\n  ideo.bandData = {};\n}\n\nlet configuredCss = staticCss;\nfunction configureTextStyle(ideo) {\n  const config = ideo.config;\n  if (!config.chrLabelSize) ideo.config.chrLabelSize = 9;\n  if (!config.chrLabelColor) ideo.config.chrLabelColor = '#000';\n  if (!config.fontFamily) ideo.config.fontFamily = '';\n\n  const size = `font-size: ${config.chrLabelSize}px`;\n  const color = `fill: ${config.chrLabelColor}`;\n  const fontFamily = `font-family: ${config.fontFamily}`;\n  configuredCss += `#_ideogram text {${fontFamily}; ${size}; ${color};}`;\n  configuredCss += `#_ideogramLabel text {${fontFamily};}`;\n}\n\n/**\n * High-level helper method for Ideogram constructor.\n *\n * @param config Configuration object.  Enables setting Ideogram properties.\n *\n * Docs: https://github.com/eweitz/ideogram/blob/master/api.md\n */\nfunction configure(config) {\n  // Clone the config object, to allow multiple instantiations\n  // without picking up prior ideogram's settings\n  this.config = JSON.parse(JSON.stringify(config));\n\n  configureMiscellaneous(this);\n  configurePloidy(this);\n  configureBands(this);\n  configureHeight(this);\n  configureWidth(this);\n  configureMargin(this);\n  configureCallbacks(config, this);\n  configureOrganisms(config, this);\n  configureBump(this);\n  configureSingleChromosome(config, this);\n  configureTextStyle(this);\n  this.initAnnotSettings();\n  if (!this.config.geometry || this.config.geometry === 'parallel') {\n    this.config.chrMargin += this.config.chrWidth;\n    if (this.config.annotationsLayout === 'heatmap') {\n      this.config.chrMargin += this.config.annotTracksHeight;\n    } else {\n      this.config.chrMargin += this.config.annotTracksHeight * 2;\n    }\n  }\n  this.init();\n}\n\nexport {configure, configuredCss};\n","/**\n * @fileoverview Functions for collinear chromosomes.\n * Collinear chromosomes form a line together, unlike the default parallel\n * geometry.\n */\n\nimport {d3} from './lib';\n\nfunction labelGenomes(ideo) {\n\n  ideo.config.taxids.forEach((taxid, i) => {\n    var org = ideo.organisms[taxid];\n    // var commonName = slug(org.commonName);\n    var scientificName = org.scientificName;\n    d3.select(ideo.selector)\n      .append('text')\n      .attr('class', 'genomeLabel italic')\n      .attr('x', 55 + 200 * i)\n      .attr('y', 10)\n      .text(scientificName)\n      .attr('text-anchor', 'middle');\n  });\n}\n\n/**\n* Rearrange chromosomes from parallel vertical to collinear vertical\n*\n* Parallel vertical (as in https://eweitz.github.io/ideogram/human)\n* | | |\n*\n* Collinear vertical (as in https://eweitz.github.io/ideogram/orthologs?loci=2:150000000,5:20000000;3:100000000,10:80000000&org=homo-sapiens&org2=mus-musculus)\n* |\n* |\n* |\n*/\nfunction rearrangeChromosomes(chrSets, yOffsets, x, ideo) {\n  var i, chrSet, y, chrLabelX, adjustedX, chr, taxid, orgIndex,\n    config = ideo.config,\n    chrLabelSize = config.chrLabelSize;\n\n  for (i = 0; i < chrSets.length; i++) {\n    chrSet = chrSets[i];\n    y = yOffsets[i] + 23 - chrLabelSize;\n\n    chr = ideo.chromosomesArray[i];\n    taxid = chr.id.split('-')[1];\n    orgIndex = ideo.config.taxids.indexOf(taxid);\n    adjustedX = x - orgIndex * 200 - 30 - 5;\n    if (orgIndex === 0) {\n      chrLabelX = -34;\n      adjustedX += ideo.config.chrWidth * 2 - 16;\n    } else {\n      chrLabelX = ideo.config.chrWidth * 2 - 24;\n    }\n\n    if (config.showChromosomeLabels) {\n      const labelSpan = chrSet.querySelector('.chrLabel > tspan');\n      labelSpan.setAttribute('x', chrLabelX);\n      labelSpan.setAttribute('dy', chrLabelSize - 8);\n      chrSet.querySelector('.chrLabel').setAttribute('text-anchor', 'start');\n    }\n    chrSet.setAttribute(\n      'transform', 'rotate(90) translate(' + y + ',' + adjustedX + ')'\n    );\n    chrSet.querySelector('.chromosome').setAttribute(\n      'transform', 'translate(-13, 10)'\n    );\n  }\n\n  labelGenomes(ideo);\n}\n\n/**\n* Get pixel coordinates to use for rearrangement\n*/\nfunction getYOffsets(chrSets, ideo) {\n  var yOffsets, i, index, chr, prevChr, y, prevWidth, prevY, yBump, taxid,\n    seenTaxids = {};\n\n  yOffsets = [];\n  for (i = 0; i < chrSets.length; i++) {\n    chr = ideo.chromosomesArray[i];\n    taxid = chr.id.split('-')[1];\n    index = (i === 0) ? i : i - 1;\n    prevChr = ideo.chromosomesArray[index];\n    if (i === 0 || taxid in seenTaxids === false) {\n      y = 20;\n      seenTaxids[taxid] = 1;\n    } else {\n      prevWidth = prevChr.width;\n      prevY = yOffsets[index];\n      yBump = (ideo.config.showChromosomeLabels ? 0 : 2);\n      y = prevY + prevWidth + yBump + ideo.config.chrMargin;\n    }\n    yOffsets.push(y);\n  }\n\n  return yOffsets;\n}\n\nfunction collinearizeVerticalChromosomes(ideo) {\n  var chrSets, yOffsets, x, height, width,\n    config = ideo.config;\n\n  ideo.config.annotLabelHeight = 12;\n  // var annotLabelHeight = ideo.config.annotLabelHeight;\n\n  if ('demarcateCollinearChromosomes' in ideo.config === false) {\n    ideo.config.demarcateCollinearChromosomes = true;\n  }\n\n  chrSets = document.querySelectorAll('.chromosome-set');\n\n  x = -40;\n\n  yOffsets = getYOffsets(chrSets, ideo);\n  rearrangeChromosomes(chrSets, yOffsets, x, ideo);\n\n  width = Math.round(yOffsets.slice(-1)[0] + 70);\n\n  if (config.multiorganism) {\n    height *= 8;\n    var maxHeight = 0;\n    yOffsets.forEach(d => {\n      if (d > maxHeight) maxHeight = d;\n    });\n    height = maxHeight + 30;\n  } else {\n    height = xOffsets.slice(-1)[0] + 30;\n  }\n\n  d3.select(ideo.selector)\n    .attr('height', height)\n    .attr('width', width);\n\n  d3.select('#_ideogramTrackLabelContainer').remove();\n  d3.select('#_ideogramInnerWrap')\n    .insert('div', ':first-child')\n    .attr('id', '_ideogramTrackLabelContainer')\n    .style('position', 'absolute');\n}\n\nexport default collinearizeVerticalChromosomes;\n","/**\n * @fileoverview Functions for collinear chromosomes.\n * Collinear chromosomes form a line together, unlike the default parallel\n * geometry.\n */\n\nimport {d3} from './lib';\nimport collinearizeVerticalChromosomes from './collinear-vertical';\n\nfunction labelGenomes(ideo) {\n\n  ideo.config.taxids.forEach((taxid, i) => {\n    var org = ideo.organisms[taxid];\n    var config = ideo.config;\n    // var commonName = slug(org.commonName);\n    var scientificName = org.scientificName;\n    d3.select(ideo.selector)\n      .append('text')\n      .attr('class', 'genomeLabel italic')\n      .attr('x', 5)\n      .attr('y', config.chrLabelSize + (200 + (3 * config.chrWidth)) * i)\n      .text(scientificName);\n  });\n}\n\n/**\n* Rearrange chromosomes from parallel horizontal to collinear horizontal\n*\n* Parallel horizontal (as in https://eweitz.github.io/ideogram/mouse)\n*     ---\n*     ---\n*     ---\n*\n* Collinear horizontal (as in https://eweitz.github.io/ideogram/geometry-collinear):\n*     --- --- ---\n*/\nfunction rearrangeChromosomes(chrSets, xOffsets, y, ideo) {\n  var i, chr, chrSet, taxid, x, adjustedY, orgIndex, chrLabelY,\n    config = ideo.config,\n    chrWidth = config.chrWidth,\n    chrLabelSize = config.chrLabelSize;\n\n  for (i = 0; i < chrSets.length; i++) {\n    chrSet = chrSets[i];\n    x = xOffsets[i];\n\n    chr = ideo.chromosomesArray[i];\n    taxid = chr.id.split('-')[1];\n    orgIndex = config.taxids.indexOf(taxid);\n    adjustedY = y + orgIndex * 200;\n    if (orgIndex === 0 && ideo.config.multiorganism) {\n      chrLabelY = chrLabelSize - 4;\n      adjustedY += chrWidth * 2 + chrLabelSize;\n    } else {\n      chrLabelY = chrWidth * 2 + chrLabelSize + 2;\n    }\n\n    if (ideo.config.showChromosomeLabels) {\n      chrSet.querySelector('.chrLabel').setAttribute('y', chrLabelY);\n      chrSet.querySelector('.chrLabel').setAttribute('text-anchor', 'middle');\n    }\n    chrSet.setAttribute('transform', 'translate(' + x + ',' + adjustedY + ')');\n    chrSet.querySelector('.chromosome').setAttribute(\n      'transform', 'translate(-13, 10)'\n    );\n  }\n\n  if (config.multiorganism) {\n    labelGenomes(ideo);\n  }\n}\n\n/**\n* Get pixel coordinates to use for rearrangement\n*/\nfunction getXOffsets(chrSets, ideo) {\n  var xOffsets, i, index, chr, prevChr, x, prevWidth, prevX, xBump, taxid,\n    seenTaxids = {};\n\n  xOffsets = [];\n  for (i = 0; i < chrSets.length; i++) {\n    chr = ideo.chromosomesArray[i];\n    taxid = chr.id.split('-')[1];\n    index = (i === 0) ? i : i - 1;\n    prevChr = ideo.chromosomesArray[index];\n    if (i === 0 || taxid in seenTaxids === false) {\n      x = 20;\n      seenTaxids[taxid] = 1;\n    } else {\n      prevWidth = prevChr.width;\n      prevX = xOffsets[index];\n      xBump = (ideo.config.showChromosomeLabels ? 0 : 2);\n      x = prevX + prevWidth + xBump + ideo.config.chrMargin;\n    }\n    xOffsets.push(x);\n  }\n\n  return xOffsets;\n}\n\n// /**\n//  * Track number of chromosomes in preceding organisms.\n//  * Adds an instance variable to the ideogram object to offset\n//  * chromosome indices.  Needed for multiorganism collinear ideograms.\n//  */\n// function setTaxidChrOffsets(ideo) {\n//   var taxidChrOffsets, taxidChrOffset;\n\n//   taxidChrOffsets = {};\n\n//   taxidChrOffset = 0;\n//   ideo.config.organism.forEach((org) => {\n//     var taxid, numChrs;\n//     taxid = ideo.getTaxid(org);\n//     taxidChrOffsets[taxid] = taxidChrOffset;\n//     numChrs = Object.keys(ideo.chromosomes[taxid]).length;\n//     taxidChrOffset += numChrs;\n//   });\n\n//   ideo.taxidChrOffsets = taxidChrOffsets;\n// }\n\n// /**\n//  * Change chromosome indices for multiorganism collinear ideograms\n//  * This is needed to account for x-offsets.\n//  */\n// function adjustChrIndex(ideo) {\n//   setTaxidChrOffsets(ideo);\n\n//   ideo.chromosomesArray.map((chr) => {\n//     var taxid = chr.id.split('-')[1];\n//     var taxidChrOffset = ideo.taxidChrOffsets[taxid];\n//     chr.chrIndex -= taxidChrOffset;\n//     ideo.chromosomes[taxid][chr.name].chrIndex = chr.chrIndex;\n//   });\n// }\n\nfunction collinearizeChromosomes(ideo) {\n  var chrSets, xOffsets, y, height, width,\n    config = ideo.config,\n    annotHeight = config.annotationHeight || 0;\n\n  if (config.orientation === 'vertical') {\n    collinearizeVerticalChromosomes(ideo);\n    return;\n  }\n\n  // if (config.multiorganism) adjustChrIndex(ideo);\n\n  ideo.config.annotLabelHeight = 12;\n  var annotLabelHeight = ideo.config.annotLabelHeight;\n\n  if ('demarcateCollinearChromosomes' in ideo.config === false) {\n    ideo.config.demarcateCollinearChromosomes = true;\n  }\n\n  chrSets = document.querySelectorAll('.chromosome-set');\n\n  y = (\n    (config.numAnnotTracks * (annotHeight + annotLabelHeight + 4)) -\n    config.chrWidth + 1\n  );\n\n  xOffsets = getXOffsets(chrSets, ideo);\n  rearrangeChromosomes(chrSets, xOffsets, y, ideo);\n\n  height = y + config.chrWidth * 2 + 20;\n\n  if (config.multiorganism) {\n    height *= 8;\n    var maxWidth = 0;\n    xOffsets.forEach(d => {\n      if (d > maxWidth) maxWidth = d;\n    });\n    width = maxWidth + 20;\n  } else {\n    width = xOffsets.slice(-1)[0] + 20;\n  }\n\n  d3.select(ideo.selector)\n    .attr('width', width)\n    .attr('height', height);\n\n  d3.select('#_ideogramTrackLabelContainer').remove();\n  d3.select('#_ideogramInnerWrap')\n    .insert('div', ':first-child')\n    .attr('id', '_ideogramTrackLabelContainer')\n    .style('position', 'absolute');\n}\n\nexport default collinearizeChromosomes;\n","// DEFLATE is a complex format; to read this code, you should probably check the RFC first:\n// https://tools.ietf.org/html/rfc1951\n// You may also wish to take a look at the guide I made about this program:\n// https://gist.github.com/101arrowz/253f31eb5abc3d9275ab943003ffecad\n// Some of the following code is similar to that of UZIP.js:\n// https://github.com/photopea/UZIP.js\n// However, the vast majority of the codebase has diverged from UZIP.js to increase performance and reduce bundle size.\n// Sometimes 0 will appear where -1 would be more appropriate. This is because using a uint\n// is better for memory in most engines (I *think*).\nvar ch2 = {};\nvar wk = (function (c, id, msg, transfer, cb) {\n    var w = new Worker(ch2[id] || (ch2[id] = URL.createObjectURL(new Blob([\n        c + ';addEventListener(\"error\",function(e){e=e.error;postMessage({$e$:[e.message,e.code,e.stack]})})'\n    ], { type: 'text/javascript' }))));\n    w.onmessage = function (e) {\n        var d = e.data, ed = d.$e$;\n        if (ed) {\n            var err = new Error(ed[0]);\n            err['code'] = ed[1];\n            err.stack = ed[2];\n            cb(err, null);\n        }\n        else\n            cb(null, d);\n    };\n    w.postMessage(msg, transfer);\n    return w;\n});\n\n// aliases for shorter compressed code (most minifers don't do this)\nvar u8 = Uint8Array, u16 = Uint16Array, u32 = Uint32Array;\n// fixed length extra bits\nvar fleb = new u8([0, 0, 0, 0, 0, 0, 0, 0, 1, 1, 1, 1, 2, 2, 2, 2, 3, 3, 3, 3, 4, 4, 4, 4, 5, 5, 5, 5, 0, /* unused */ 0, 0, /* impossible */ 0]);\n// fixed distance extra bits\n// see fleb note\nvar fdeb = new u8([0, 0, 0, 0, 1, 1, 2, 2, 3, 3, 4, 4, 5, 5, 6, 6, 7, 7, 8, 8, 9, 9, 10, 10, 11, 11, 12, 12, 13, 13, /* unused */ 0, 0]);\n// code length index map\nvar clim = new u8([16, 17, 18, 0, 8, 7, 9, 6, 10, 5, 11, 4, 12, 3, 13, 2, 14, 1, 15]);\n// get base, reverse index map from extra bits\nvar freb = function (eb, start) {\n    var b = new u16(31);\n    for (var i = 0; i < 31; ++i) {\n        b[i] = start += 1 << eb[i - 1];\n    }\n    // numbers here are at max 18 bits\n    var r = new u32(b[30]);\n    for (var i = 1; i < 30; ++i) {\n        for (var j = b[i]; j < b[i + 1]; ++j) {\n            r[j] = ((j - b[i]) << 5) | i;\n        }\n    }\n    return [b, r];\n};\nvar _a = freb(fleb, 2), fl = _a[0], revfl = _a[1];\n// we can ignore the fact that the other numbers are wrong; they never happen anyway\nfl[28] = 258, revfl[258] = 28;\nvar _b = freb(fdeb, 0), fd = _b[0], revfd = _b[1];\n// map of value to reverse (assuming 16 bits)\nvar rev = new u16(32768);\nfor (var i = 0; i < 32768; ++i) {\n    // reverse table algorithm from SO\n    var x = ((i & 0xAAAA) >>> 1) | ((i & 0x5555) << 1);\n    x = ((x & 0xCCCC) >>> 2) | ((x & 0x3333) << 2);\n    x = ((x & 0xF0F0) >>> 4) | ((x & 0x0F0F) << 4);\n    rev[i] = (((x & 0xFF00) >>> 8) | ((x & 0x00FF) << 8)) >>> 1;\n}\n// create huffman tree from u8 \"map\": index -> code length for code index\n// mb (max bits) must be at most 15\n// TODO: optimize/split up?\nvar hMap = (function (cd, mb, r) {\n    var s = cd.length;\n    // index\n    var i = 0;\n    // u16 \"map\": index -> # of codes with bit length = index\n    var l = new u16(mb);\n    // length of cd must be 288 (total # of codes)\n    for (; i < s; ++i) {\n        if (cd[i])\n            ++l[cd[i] - 1];\n    }\n    // u16 \"map\": index -> minimum code for bit length = index\n    var le = new u16(mb);\n    for (i = 0; i < mb; ++i) {\n        le[i] = (le[i - 1] + l[i - 1]) << 1;\n    }\n    var co;\n    if (r) {\n        // u16 \"map\": index -> number of actual bits, symbol for code\n        co = new u16(1 << mb);\n        // bits to remove for reverser\n        var rvb = 15 - mb;\n        for (i = 0; i < s; ++i) {\n            // ignore 0 lengths\n            if (cd[i]) {\n                // num encoding both symbol and bits read\n                var sv = (i << 4) | cd[i];\n                // free bits\n                var r_1 = mb - cd[i];\n                // start value\n                var v = le[cd[i] - 1]++ << r_1;\n                // m is end value\n                for (var m = v | ((1 << r_1) - 1); v <= m; ++v) {\n                    // every 16 bit value starting with the code yields the same result\n                    co[rev[v] >>> rvb] = sv;\n                }\n            }\n        }\n    }\n    else {\n        co = new u16(s);\n        for (i = 0; i < s; ++i) {\n            if (cd[i]) {\n                co[i] = rev[le[cd[i] - 1]++] >>> (15 - cd[i]);\n            }\n        }\n    }\n    return co;\n});\n// fixed length tree\nvar flt = new u8(288);\nfor (var i = 0; i < 144; ++i)\n    flt[i] = 8;\nfor (var i = 144; i < 256; ++i)\n    flt[i] = 9;\nfor (var i = 256; i < 280; ++i)\n    flt[i] = 7;\nfor (var i = 280; i < 288; ++i)\n    flt[i] = 8;\n// fixed distance tree\nvar fdt = new u8(32);\nfor (var i = 0; i < 32; ++i)\n    fdt[i] = 5;\n// fixed length map\nvar flm = /*#__PURE__*/ hMap(flt, 9, 0), flrm = /*#__PURE__*/ hMap(flt, 9, 1);\n// fixed distance map\nvar fdm = /*#__PURE__*/ hMap(fdt, 5, 0), fdrm = /*#__PURE__*/ hMap(fdt, 5, 1);\n// find max of array\nvar max = function (a) {\n    var m = a[0];\n    for (var i = 1; i < a.length; ++i) {\n        if (a[i] > m)\n            m = a[i];\n    }\n    return m;\n};\n// read d, starting at bit p and mask with m\nvar bits = function (d, p, m) {\n    var o = (p / 8) | 0;\n    return ((d[o] | (d[o + 1] << 8)) >> (p & 7)) & m;\n};\n// read d, starting at bit p continuing for at least 16 bits\nvar bits16 = function (d, p) {\n    var o = (p / 8) | 0;\n    return ((d[o] | (d[o + 1] << 8) | (d[o + 2] << 16)) >> (p & 7));\n};\n// get end of byte\nvar shft = function (p) { return ((p + 7) / 8) | 0; };\n// typed array slice - allows garbage collector to free original reference,\n// while being more compatible than .slice\nvar slc = function (v, s, e) {\n    if (s == null || s < 0)\n        s = 0;\n    if (e == null || e > v.length)\n        e = v.length;\n    // can't use .constructor in case user-supplied\n    var n = new (v.BYTES_PER_ELEMENT == 2 ? u16 : v.BYTES_PER_ELEMENT == 4 ? u32 : u8)(e - s);\n    n.set(v.subarray(s, e));\n    return n;\n};\n/**\n * Codes for errors generated within this library\n */\nexport var FlateErrorCode = {\n    UnexpectedEOF: 0,\n    InvalidBlockType: 1,\n    InvalidLengthLiteral: 2,\n    InvalidDistance: 3,\n    StreamFinished: 4,\n    NoStreamHandler: 5,\n    InvalidHeader: 6,\n    NoCallback: 7,\n    InvalidUTF8: 8,\n    ExtraFieldTooLong: 9,\n    InvalidDate: 10,\n    FilenameTooLong: 11,\n    StreamFinishing: 12,\n    InvalidZipData: 13,\n    UnknownCompressionMethod: 14\n};\n// error codes\nvar ec = [\n    'unexpected EOF',\n    'invalid block type',\n    'invalid length/literal',\n    'invalid distance',\n    'stream finished',\n    'no stream handler',\n    ,\n    'no callback',\n    'invalid UTF-8 data',\n    'extra field too long',\n    'date not in range 1980-2099',\n    'filename too long',\n    'stream finishing',\n    'invalid zip data'\n    // determined by unknown compression method\n];\n;\nvar err = function (ind, msg, nt) {\n    var e = new Error(msg || ec[ind]);\n    e.code = ind;\n    if (Error.captureStackTrace)\n        Error.captureStackTrace(e, err);\n    if (!nt)\n        throw e;\n    return e;\n};\n// expands raw DEFLATE data\nvar inflt = function (dat, buf, st) {\n    // source length\n    var sl = dat.length;\n    if (!sl || (st && st.f && !st.l))\n        return buf || new u8(0);\n    // have to estimate size\n    var noBuf = !buf || st;\n    // no state\n    var noSt = !st || st.i;\n    if (!st)\n        st = {};\n    // Assumes roughly 33% compression ratio average\n    if (!buf)\n        buf = new u8(sl * 3);\n    // ensure buffer can fit at least l elements\n    var cbuf = function (l) {\n        var bl = buf.length;\n        // need to increase size to fit\n        if (l > bl) {\n            // Double or set to necessary, whichever is greater\n            var nbuf = new u8(Math.max(bl * 2, l));\n            nbuf.set(buf);\n            buf = nbuf;\n        }\n    };\n    //  last chunk         bitpos           bytes\n    var final = st.f || 0, pos = st.p || 0, bt = st.b || 0, lm = st.l, dm = st.d, lbt = st.m, dbt = st.n;\n    // total bits\n    var tbts = sl * 8;\n    do {\n        if (!lm) {\n            // BFINAL - this is only 1 when last chunk is next\n            final = bits(dat, pos, 1);\n            // type: 0 = no compression, 1 = fixed huffman, 2 = dynamic huffman\n            var type = bits(dat, pos + 1, 3);\n            pos += 3;\n            if (!type) {\n                // go to end of byte boundary\n                var s = shft(pos) + 4, l = dat[s - 4] | (dat[s - 3] << 8), t = s + l;\n                if (t > sl) {\n                    if (noSt)\n                        err(0);\n                    break;\n                }\n                // ensure size\n                if (noBuf)\n                    cbuf(bt + l);\n                // Copy over uncompressed data\n                buf.set(dat.subarray(s, t), bt);\n                // Get new bitpos, update byte count\n                st.b = bt += l, st.p = pos = t * 8, st.f = final;\n                continue;\n            }\n            else if (type == 1)\n                lm = flrm, dm = fdrm, lbt = 9, dbt = 5;\n            else if (type == 2) {\n                //  literal                            lengths\n                var hLit = bits(dat, pos, 31) + 257, hcLen = bits(dat, pos + 10, 15) + 4;\n                var tl = hLit + bits(dat, pos + 5, 31) + 1;\n                pos += 14;\n                // length+distance tree\n                var ldt = new u8(tl);\n                // code length tree\n                var clt = new u8(19);\n                for (var i = 0; i < hcLen; ++i) {\n                    // use index map to get real code\n                    clt[clim[i]] = bits(dat, pos + i * 3, 7);\n                }\n                pos += hcLen * 3;\n                // code lengths bits\n                var clb = max(clt), clbmsk = (1 << clb) - 1;\n                // code lengths map\n                var clm = hMap(clt, clb, 1);\n                for (var i = 0; i < tl;) {\n                    var r = clm[bits(dat, pos, clbmsk)];\n                    // bits read\n                    pos += r & 15;\n                    // symbol\n                    var s = r >>> 4;\n                    // code length to copy\n                    if (s < 16) {\n                        ldt[i++] = s;\n                    }\n                    else {\n                        //  copy   count\n                        var c = 0, n = 0;\n                        if (s == 16)\n                            n = 3 + bits(dat, pos, 3), pos += 2, c = ldt[i - 1];\n                        else if (s == 17)\n                            n = 3 + bits(dat, pos, 7), pos += 3;\n                        else if (s == 18)\n                            n = 11 + bits(dat, pos, 127), pos += 7;\n                        while (n--)\n                            ldt[i++] = c;\n                    }\n                }\n                //    length tree                 distance tree\n                var lt = ldt.subarray(0, hLit), dt = ldt.subarray(hLit);\n                // max length bits\n                lbt = max(lt);\n                // max dist bits\n                dbt = max(dt);\n                lm = hMap(lt, lbt, 1);\n                dm = hMap(dt, dbt, 1);\n            }\n            else\n                err(1);\n            if (pos > tbts) {\n                if (noSt)\n                    err(0);\n                break;\n            }\n        }\n        // Make sure the buffer can hold this + the largest possible addition\n        // Maximum chunk size (practically, theoretically infinite) is 2^17;\n        if (noBuf)\n            cbuf(bt + 131072);\n        var lms = (1 << lbt) - 1, dms = (1 << dbt) - 1;\n        var lpos = pos;\n        for (;; lpos = pos) {\n            // bits read, code\n            var c = lm[bits16(dat, pos) & lms], sym = c >>> 4;\n            pos += c & 15;\n            if (pos > tbts) {\n                if (noSt)\n                    err(0);\n                break;\n            }\n            if (!c)\n                err(2);\n            if (sym < 256)\n                buf[bt++] = sym;\n            else if (sym == 256) {\n                lpos = pos, lm = null;\n                break;\n            }\n            else {\n                var add = sym - 254;\n                // no extra bits needed if less\n                if (sym > 264) {\n                    // index\n                    var i = sym - 257, b = fleb[i];\n                    add = bits(dat, pos, (1 << b) - 1) + fl[i];\n                    pos += b;\n                }\n                // dist\n                var d = dm[bits16(dat, pos) & dms], dsym = d >>> 4;\n                if (!d)\n                    err(3);\n                pos += d & 15;\n                var dt = fd[dsym];\n                if (dsym > 3) {\n                    var b = fdeb[dsym];\n                    dt += bits16(dat, pos) & ((1 << b) - 1), pos += b;\n                }\n                if (pos > tbts) {\n                    if (noSt)\n                        err(0);\n                    break;\n                }\n                if (noBuf)\n                    cbuf(bt + 131072);\n                var end = bt + add;\n                for (; bt < end; bt += 4) {\n                    buf[bt] = buf[bt - dt];\n                    buf[bt + 1] = buf[bt + 1 - dt];\n                    buf[bt + 2] = buf[bt + 2 - dt];\n                    buf[bt + 3] = buf[bt + 3 - dt];\n                }\n                bt = end;\n            }\n        }\n        st.l = lm, st.p = lpos, st.b = bt, st.f = final;\n        if (lm)\n            final = 1, st.m = lbt, st.d = dm, st.n = dbt;\n    } while (!final);\n    return bt == buf.length ? buf : slc(buf, 0, bt);\n};\n// starting at p, write the minimum number of bits that can hold v to d\nvar wbits = function (d, p, v) {\n    v <<= p & 7;\n    var o = (p / 8) | 0;\n    d[o] |= v;\n    d[o + 1] |= v >>> 8;\n};\n// starting at p, write the minimum number of bits (>8) that can hold v to d\nvar wbits16 = function (d, p, v) {\n    v <<= p & 7;\n    var o = (p / 8) | 0;\n    d[o] |= v;\n    d[o + 1] |= v >>> 8;\n    d[o + 2] |= v >>> 16;\n};\n// creates code lengths from a frequency table\nvar hTree = function (d, mb) {\n    // Need extra info to make a tree\n    var t = [];\n    for (var i = 0; i < d.length; ++i) {\n        if (d[i])\n            t.push({ s: i, f: d[i] });\n    }\n    var s = t.length;\n    var t2 = t.slice();\n    if (!s)\n        return [et, 0];\n    if (s == 1) {\n        var v = new u8(t[0].s + 1);\n        v[t[0].s] = 1;\n        return [v, 1];\n    }\n    t.sort(function (a, b) { return a.f - b.f; });\n    // after i2 reaches last ind, will be stopped\n    // freq must be greater than largest possible number of symbols\n    t.push({ s: -1, f: 25001 });\n    var l = t[0], r = t[1], i0 = 0, i1 = 1, i2 = 2;\n    t[0] = { s: -1, f: l.f + r.f, l: l, r: r };\n    // efficient algorithm from UZIP.js\n    // i0 is lookbehind, i2 is lookahead - after processing two low-freq\n    // symbols that combined have high freq, will start processing i2 (high-freq,\n    // non-composite) symbols instead\n    // see https://reddit.com/r/photopea/comments/ikekht/uzipjs_questions/\n    while (i1 != s - 1) {\n        l = t[t[i0].f < t[i2].f ? i0++ : i2++];\n        r = t[i0 != i1 && t[i0].f < t[i2].f ? i0++ : i2++];\n        t[i1++] = { s: -1, f: l.f + r.f, l: l, r: r };\n    }\n    var maxSym = t2[0].s;\n    for (var i = 1; i < s; ++i) {\n        if (t2[i].s > maxSym)\n            maxSym = t2[i].s;\n    }\n    // code lengths\n    var tr = new u16(maxSym + 1);\n    // max bits in tree\n    var mbt = ln(t[i1 - 1], tr, 0);\n    if (mbt > mb) {\n        // more algorithms from UZIP.js\n        // TODO: find out how this code works (debt)\n        //  ind    debt\n        var i = 0, dt = 0;\n        //    left            cost\n        var lft = mbt - mb, cst = 1 << lft;\n        t2.sort(function (a, b) { return tr[b.s] - tr[a.s] || a.f - b.f; });\n        for (; i < s; ++i) {\n            var i2_1 = t2[i].s;\n            if (tr[i2_1] > mb) {\n                dt += cst - (1 << (mbt - tr[i2_1]));\n                tr[i2_1] = mb;\n            }\n            else\n                break;\n        }\n        dt >>>= lft;\n        while (dt > 0) {\n            var i2_2 = t2[i].s;\n            if (tr[i2_2] < mb)\n                dt -= 1 << (mb - tr[i2_2]++ - 1);\n            else\n                ++i;\n        }\n        for (; i >= 0 && dt; --i) {\n            var i2_3 = t2[i].s;\n            if (tr[i2_3] == mb) {\n                --tr[i2_3];\n                ++dt;\n            }\n        }\n        mbt = mb;\n    }\n    return [new u8(tr), mbt];\n};\n// get the max length and assign length codes\nvar ln = function (n, l, d) {\n    return n.s == -1\n        ? Math.max(ln(n.l, l, d + 1), ln(n.r, l, d + 1))\n        : (l[n.s] = d);\n};\n// length codes generation\nvar lc = function (c) {\n    var s = c.length;\n    // Note that the semicolon was intentional\n    while (s && !c[--s])\n        ;\n    var cl = new u16(++s);\n    //  ind      num         streak\n    var cli = 0, cln = c[0], cls = 1;\n    var w = function (v) { cl[cli++] = v; };\n    for (var i = 1; i <= s; ++i) {\n        if (c[i] == cln && i != s)\n            ++cls;\n        else {\n            if (!cln && cls > 2) {\n                for (; cls > 138; cls -= 138)\n                    w(32754);\n                if (cls > 2) {\n                    w(cls > 10 ? ((cls - 11) << 5) | 28690 : ((cls - 3) << 5) | 12305);\n                    cls = 0;\n                }\n            }\n            else if (cls > 3) {\n                w(cln), --cls;\n                for (; cls > 6; cls -= 6)\n                    w(8304);\n                if (cls > 2)\n                    w(((cls - 3) << 5) | 8208), cls = 0;\n            }\n            while (cls--)\n                w(cln);\n            cls = 1;\n            cln = c[i];\n        }\n    }\n    return [cl.subarray(0, cli), s];\n};\n// calculate the length of output from tree, code lengths\nvar clen = function (cf, cl) {\n    var l = 0;\n    for (var i = 0; i < cl.length; ++i)\n        l += cf[i] * cl[i];\n    return l;\n};\n// writes a fixed block\n// returns the new bit pos\nvar wfblk = function (out, pos, dat) {\n    // no need to write 00 as type: TypedArray defaults to 0\n    var s = dat.length;\n    var o = shft(pos + 2);\n    out[o] = s & 255;\n    out[o + 1] = s >>> 8;\n    out[o + 2] = out[o] ^ 255;\n    out[o + 3] = out[o + 1] ^ 255;\n    for (var i = 0; i < s; ++i)\n        out[o + i + 4] = dat[i];\n    return (o + 4 + s) * 8;\n};\n// writes a block\nvar wblk = function (dat, out, final, syms, lf, df, eb, li, bs, bl, p) {\n    wbits(out, p++, final);\n    ++lf[256];\n    var _a = hTree(lf, 15), dlt = _a[0], mlb = _a[1];\n    var _b = hTree(df, 15), ddt = _b[0], mdb = _b[1];\n    var _c = lc(dlt), lclt = _c[0], nlc = _c[1];\n    var _d = lc(ddt), lcdt = _d[0], ndc = _d[1];\n    var lcfreq = new u16(19);\n    for (var i = 0; i < lclt.length; ++i)\n        lcfreq[lclt[i] & 31]++;\n    for (var i = 0; i < lcdt.length; ++i)\n        lcfreq[lcdt[i] & 31]++;\n    var _e = hTree(lcfreq, 7), lct = _e[0], mlcb = _e[1];\n    var nlcc = 19;\n    for (; nlcc > 4 && !lct[clim[nlcc - 1]]; --nlcc)\n        ;\n    var flen = (bl + 5) << 3;\n    var ftlen = clen(lf, flt) + clen(df, fdt) + eb;\n    var dtlen = clen(lf, dlt) + clen(df, ddt) + eb + 14 + 3 * nlcc + clen(lcfreq, lct) + (2 * lcfreq[16] + 3 * lcfreq[17] + 7 * lcfreq[18]);\n    if (flen <= ftlen && flen <= dtlen)\n        return wfblk(out, p, dat.subarray(bs, bs + bl));\n    var lm, ll, dm, dl;\n    wbits(out, p, 1 + (dtlen < ftlen)), p += 2;\n    if (dtlen < ftlen) {\n        lm = hMap(dlt, mlb, 0), ll = dlt, dm = hMap(ddt, mdb, 0), dl = ddt;\n        var llm = hMap(lct, mlcb, 0);\n        wbits(out, p, nlc - 257);\n        wbits(out, p + 5, ndc - 1);\n        wbits(out, p + 10, nlcc - 4);\n        p += 14;\n        for (var i = 0; i < nlcc; ++i)\n            wbits(out, p + 3 * i, lct[clim[i]]);\n        p += 3 * nlcc;\n        var lcts = [lclt, lcdt];\n        for (var it = 0; it < 2; ++it) {\n            var clct = lcts[it];\n            for (var i = 0; i < clct.length; ++i) {\n                var len = clct[i] & 31;\n                wbits(out, p, llm[len]), p += lct[len];\n                if (len > 15)\n                    wbits(out, p, (clct[i] >>> 5) & 127), p += clct[i] >>> 12;\n            }\n        }\n    }\n    else {\n        lm = flm, ll = flt, dm = fdm, dl = fdt;\n    }\n    for (var i = 0; i < li; ++i) {\n        if (syms[i] > 255) {\n            var len = (syms[i] >>> 18) & 31;\n            wbits16(out, p, lm[len + 257]), p += ll[len + 257];\n            if (len > 7)\n                wbits(out, p, (syms[i] >>> 23) & 31), p += fleb[len];\n            var dst = syms[i] & 31;\n            wbits16(out, p, dm[dst]), p += dl[dst];\n            if (dst > 3)\n                wbits16(out, p, (syms[i] >>> 5) & 8191), p += fdeb[dst];\n        }\n        else {\n            wbits16(out, p, lm[syms[i]]), p += ll[syms[i]];\n        }\n    }\n    wbits16(out, p, lm[256]);\n    return p + ll[256];\n};\n// deflate options (nice << 13) | chain\nvar deo = /*#__PURE__*/ new u32([65540, 131080, 131088, 131104, 262176, 1048704, 1048832, 2114560, 2117632]);\n// empty\nvar et = /*#__PURE__*/ new u8(0);\n// compresses data into a raw DEFLATE buffer\nvar dflt = function (dat, lvl, plvl, pre, post, lst) {\n    var s = dat.length;\n    var o = new u8(pre + s + 5 * (1 + Math.ceil(s / 7000)) + post);\n    // writing to this writes to the output buffer\n    var w = o.subarray(pre, o.length - post);\n    var pos = 0;\n    if (!lvl || s < 8) {\n        for (var i = 0; i <= s; i += 65535) {\n            // end\n            var e = i + 65535;\n            if (e >= s) {\n                // write final block\n                w[pos >> 3] = lst;\n            }\n            pos = wfblk(w, pos + 1, dat.subarray(i, e));\n        }\n    }\n    else {\n        var opt = deo[lvl - 1];\n        var n = opt >>> 13, c = opt & 8191;\n        var msk_1 = (1 << plvl) - 1;\n        //    prev 2-byte val map    curr 2-byte val map\n        var prev = new u16(32768), head = new u16(msk_1 + 1);\n        var bs1_1 = Math.ceil(plvl / 3), bs2_1 = 2 * bs1_1;\n        var hsh = function (i) { return (dat[i] ^ (dat[i + 1] << bs1_1) ^ (dat[i + 2] << bs2_1)) & msk_1; };\n        // 24576 is an arbitrary number of maximum symbols per block\n        // 424 buffer for last block\n        var syms = new u32(25000);\n        // length/literal freq   distance freq\n        var lf = new u16(288), df = new u16(32);\n        //  l/lcnt  exbits  index  l/lind  waitdx  bitpos\n        var lc_1 = 0, eb = 0, i = 0, li = 0, wi = 0, bs = 0;\n        for (; i < s; ++i) {\n            // hash value\n            // deopt when i > s - 3 - at end, deopt acceptable\n            var hv = hsh(i);\n            // index mod 32768    previous index mod\n            var imod = i & 32767, pimod = head[hv];\n            prev[imod] = pimod;\n            head[hv] = imod;\n            // We always should modify head and prev, but only add symbols if\n            // this data is not yet processed (\"wait\" for wait index)\n            if (wi <= i) {\n                // bytes remaining\n                var rem = s - i;\n                if ((lc_1 > 7000 || li > 24576) && rem > 423) {\n                    pos = wblk(dat, w, 0, syms, lf, df, eb, li, bs, i - bs, pos);\n                    li = lc_1 = eb = 0, bs = i;\n                    for (var j = 0; j < 286; ++j)\n                        lf[j] = 0;\n                    for (var j = 0; j < 30; ++j)\n                        df[j] = 0;\n                }\n                //  len    dist   chain\n                var l = 2, d = 0, ch_1 = c, dif = (imod - pimod) & 32767;\n                if (rem > 2 && hv == hsh(i - dif)) {\n                    var maxn = Math.min(n, rem) - 1;\n                    var maxd = Math.min(32767, i);\n                    // max possible length\n                    // not capped at dif because decompressors implement \"rolling\" index population\n                    var ml = Math.min(258, rem);\n                    while (dif <= maxd && --ch_1 && imod != pimod) {\n                        if (dat[i + l] == dat[i + l - dif]) {\n                            var nl = 0;\n                            for (; nl < ml && dat[i + nl] == dat[i + nl - dif]; ++nl)\n                                ;\n                            if (nl > l) {\n                                l = nl, d = dif;\n                                // break out early when we reach \"nice\" (we are satisfied enough)\n                                if (nl > maxn)\n                                    break;\n                                // now, find the rarest 2-byte sequence within this\n                                // length of literals and search for that instead.\n                                // Much faster than just using the start\n                                var mmd = Math.min(dif, nl - 2);\n                                var md = 0;\n                                for (var j = 0; j < mmd; ++j) {\n                                    var ti = (i - dif + j + 32768) & 32767;\n                                    var pti = prev[ti];\n                                    var cd = (ti - pti + 32768) & 32767;\n                                    if (cd > md)\n                                        md = cd, pimod = ti;\n                                }\n                            }\n                        }\n                        // check the previous match\n                        imod = pimod, pimod = prev[imod];\n                        dif += (imod - pimod + 32768) & 32767;\n                    }\n                }\n                // d will be nonzero only when a match was found\n                if (d) {\n                    // store both dist and len data in one Uint32\n                    // Make sure this is recognized as a len/dist with 28th bit (2^28)\n                    syms[li++] = 268435456 | (revfl[l] << 18) | revfd[d];\n                    var lin = revfl[l] & 31, din = revfd[d] & 31;\n                    eb += fleb[lin] + fdeb[din];\n                    ++lf[257 + lin];\n                    ++df[din];\n                    wi = i + l;\n                    ++lc_1;\n                }\n                else {\n                    syms[li++] = dat[i];\n                    ++lf[dat[i]];\n                }\n            }\n        }\n        pos = wblk(dat, w, lst, syms, lf, df, eb, li, bs, i - bs, pos);\n        // this is the easiest way to avoid needing to maintain state\n        if (!lst && pos & 7)\n            pos = wfblk(w, pos + 1, et);\n    }\n    return slc(o, 0, pre + shft(pos) + post);\n};\n// CRC32 table\nvar crct = /*#__PURE__*/ (function () {\n    var t = new Int32Array(256);\n    for (var i = 0; i < 256; ++i) {\n        var c = i, k = 9;\n        while (--k)\n            c = ((c & 1) && -306674912) ^ (c >>> 1);\n        t[i] = c;\n    }\n    return t;\n})();\n// CRC32\nvar crc = function () {\n    var c = -1;\n    return {\n        p: function (d) {\n            // closures have awful performance\n            var cr = c;\n            for (var i = 0; i < d.length; ++i)\n                cr = crct[(cr & 255) ^ d[i]] ^ (cr >>> 8);\n            c = cr;\n        },\n        d: function () { return ~c; }\n    };\n};\n// Alder32\nvar adler = function () {\n    var a = 1, b = 0;\n    return {\n        p: function (d) {\n            // closures have awful performance\n            var n = a, m = b;\n            var l = d.length | 0;\n            for (var i = 0; i != l;) {\n                var e = Math.min(i + 2655, l);\n                for (; i < e; ++i)\n                    m += n += d[i];\n                n = (n & 65535) + 15 * (n >> 16), m = (m & 65535) + 15 * (m >> 16);\n            }\n            a = n, b = m;\n        },\n        d: function () {\n            a %= 65521, b %= 65521;\n            return (a & 255) << 24 | (a >>> 8) << 16 | (b & 255) << 8 | (b >>> 8);\n        }\n    };\n};\n;\n// deflate with opts\nvar dopt = function (dat, opt, pre, post, st) {\n    return dflt(dat, opt.level == null ? 6 : opt.level, opt.mem == null ? Math.ceil(Math.max(8, Math.min(13, Math.log(dat.length))) * 1.5) : (12 + opt.mem), pre, post, !st);\n};\n// Walmart object spread\nvar mrg = function (a, b) {\n    var o = {};\n    for (var k in a)\n        o[k] = a[k];\n    for (var k in b)\n        o[k] = b[k];\n    return o;\n};\n// worker clone\n// This is possibly the craziest part of the entire codebase, despite how simple it may seem.\n// The only parameter to this function is a closure that returns an array of variables outside of the function scope.\n// We're going to try to figure out the variable names used in the closure as strings because that is crucial for workerization.\n// We will return an object mapping of true variable name to value (basically, the current scope as a JS object).\n// The reason we can't just use the original variable names is minifiers mangling the toplevel scope.\n// This took me three weeks to figure out how to do.\nvar wcln = function (fn, fnStr, td) {\n    var dt = fn();\n    var st = fn.toString();\n    var ks = st.slice(st.indexOf('[') + 1, st.lastIndexOf(']')).replace(/\\s+/g, '').split(',');\n    for (var i = 0; i < dt.length; ++i) {\n        var v = dt[i], k = ks[i];\n        if (typeof v == 'function') {\n            fnStr += ';' + k + '=';\n            var st_1 = v.toString();\n            if (v.prototype) {\n                // for global objects\n                if (st_1.indexOf('[native code]') != -1) {\n                    var spInd = st_1.indexOf(' ', 8) + 1;\n                    fnStr += st_1.slice(spInd, st_1.indexOf('(', spInd));\n                }\n                else {\n                    fnStr += st_1;\n                    for (var t in v.prototype)\n                        fnStr += ';' + k + '.prototype.' + t + '=' + v.prototype[t].toString();\n                }\n            }\n            else\n                fnStr += st_1;\n        }\n        else\n            td[k] = v;\n    }\n    return [fnStr, td];\n};\nvar ch = [];\n// clone bufs\nvar cbfs = function (v) {\n    var tl = [];\n    for (var k in v) {\n        if (v[k].buffer) {\n            tl.push((v[k] = new v[k].constructor(v[k])).buffer);\n        }\n    }\n    return tl;\n};\n// use a worker to execute code\nvar wrkr = function (fns, init, id, cb) {\n    var _a;\n    if (!ch[id]) {\n        var fnStr = '', td_1 = {}, m = fns.length - 1;\n        for (var i = 0; i < m; ++i)\n            _a = wcln(fns[i], fnStr, td_1), fnStr = _a[0], td_1 = _a[1];\n        ch[id] = wcln(fns[m], fnStr, td_1);\n    }\n    var td = mrg({}, ch[id][1]);\n    return wk(ch[id][0] + ';onmessage=function(e){for(var k in e.data)self[k]=e.data[k];onmessage=' + init.toString() + '}', id, td, cbfs(td), cb);\n};\n// base async inflate fn\nvar bInflt = function () { return [u8, u16, u32, fleb, fdeb, clim, fl, fd, flrm, fdrm, rev, ec, hMap, max, bits, bits16, shft, slc, err, inflt, inflateSync, pbf, gu8]; };\nvar bDflt = function () { return [u8, u16, u32, fleb, fdeb, clim, revfl, revfd, flm, flt, fdm, fdt, rev, deo, et, hMap, wbits, wbits16, hTree, ln, lc, clen, wfblk, wblk, shft, slc, dflt, dopt, deflateSync, pbf]; };\n// gzip extra\nvar gze = function () { return [gzh, gzhl, wbytes, crc, crct]; };\n// gunzip extra\nvar guze = function () { return [gzs, gzl]; };\n// zlib extra\nvar zle = function () { return [zlh, wbytes, adler]; };\n// unzlib extra\nvar zule = function () { return [zlv]; };\n// post buf\nvar pbf = function (msg) { return postMessage(msg, [msg.buffer]); };\n// get u8\nvar gu8 = function (o) { return o && o.size && new u8(o.size); };\n// async helper\nvar cbify = function (dat, opts, fns, init, id, cb) {\n    var w = wrkr(fns, init, id, function (err, dat) {\n        w.terminate();\n        cb(err, dat);\n    });\n    w.postMessage([dat, opts], opts.consume ? [dat.buffer] : []);\n    return function () { w.terminate(); };\n};\n// auto stream\nvar astrm = function (strm) {\n    strm.ondata = function (dat, final) { return postMessage([dat, final], [dat.buffer]); };\n    return function (ev) { return strm.push(ev.data[0], ev.data[1]); };\n};\n// async stream attach\nvar astrmify = function (fns, strm, opts, init, id) {\n    var t;\n    var w = wrkr(fns, init, id, function (err, dat) {\n        if (err)\n            w.terminate(), strm.ondata.call(strm, err);\n        else {\n            if (dat[1])\n                w.terminate();\n            strm.ondata.call(strm, err, dat[0], dat[1]);\n        }\n    });\n    w.postMessage(opts);\n    strm.push = function (d, f) {\n        if (!strm.ondata)\n            err(5);\n        if (t)\n            strm.ondata(err(4, 0, 1), null, !!f);\n        w.postMessage([d, t = f], [d.buffer]);\n    };\n    strm.terminate = function () { w.terminate(); };\n};\n// read 2 bytes\nvar b2 = function (d, b) { return d[b] | (d[b + 1] << 8); };\n// read 4 bytes\nvar b4 = function (d, b) { return (d[b] | (d[b + 1] << 8) | (d[b + 2] << 16) | (d[b + 3] << 24)) >>> 0; };\nvar b8 = function (d, b) { return b4(d, b) + (b4(d, b + 4) * 4294967296); };\n// write bytes\nvar wbytes = function (d, b, v) {\n    for (; v; ++b)\n        d[b] = v, v >>>= 8;\n};\n// gzip header\nvar gzh = function (c, o) {\n    var fn = o.filename;\n    c[0] = 31, c[1] = 139, c[2] = 8, c[8] = o.level < 2 ? 4 : o.level == 9 ? 2 : 0, c[9] = 3; // assume Unix\n    if (o.mtime != 0)\n        wbytes(c, 4, Math.floor(new Date(o.mtime || Date.now()) / 1000));\n    if (fn) {\n        c[3] = 8;\n        for (var i = 0; i <= fn.length; ++i)\n            c[i + 10] = fn.charCodeAt(i);\n    }\n};\n// gzip footer: -8 to -4 = CRC, -4 to -0 is length\n// gzip start\nvar gzs = function (d) {\n    if (d[0] != 31 || d[1] != 139 || d[2] != 8)\n        err(6, 'invalid gzip data');\n    var flg = d[3];\n    var st = 10;\n    if (flg & 4)\n        st += d[10] | (d[11] << 8) + 2;\n    for (var zs = (flg >> 3 & 1) + (flg >> 4 & 1); zs > 0; zs -= !d[st++])\n        ;\n    return st + (flg & 2);\n};\n// gzip length\nvar gzl = function (d) {\n    var l = d.length;\n    return ((d[l - 4] | d[l - 3] << 8 | d[l - 2] << 16) | (d[l - 1] << 24)) >>> 0;\n};\n// gzip header length\nvar gzhl = function (o) { return 10 + ((o.filename && (o.filename.length + 1)) || 0); };\n// zlib header\nvar zlh = function (c, o) {\n    var lv = o.level, fl = lv == 0 ? 0 : lv < 6 ? 1 : lv == 9 ? 3 : 2;\n    c[0] = 120, c[1] = (fl << 6) | (fl ? (32 - 2 * fl) : 1);\n};\n// zlib valid\nvar zlv = function (d) {\n    if ((d[0] & 15) != 8 || (d[0] >>> 4) > 7 || ((d[0] << 8 | d[1]) % 31))\n        err(6, 'invalid zlib data');\n    if (d[1] & 32)\n        err(6, 'invalid zlib data: preset dictionaries not supported');\n};\nfunction AsyncCmpStrm(opts, cb) {\n    if (!cb && typeof opts == 'function')\n        cb = opts, opts = {};\n    this.ondata = cb;\n    return opts;\n}\n// zlib footer: -4 to -0 is Adler32\n/**\n * Streaming DEFLATE compression\n */\nvar Deflate = /*#__PURE__*/ (function () {\n    function Deflate(opts, cb) {\n        if (!cb && typeof opts == 'function')\n            cb = opts, opts = {};\n        this.ondata = cb;\n        this.o = opts || {};\n    }\n    Deflate.prototype.p = function (c, f) {\n        this.ondata(dopt(c, this.o, 0, 0, !f), f);\n    };\n    /**\n     * Pushes a chunk to be deflated\n     * @param chunk The chunk to push\n     * @param final Whether this is the last chunk\n     */\n    Deflate.prototype.push = function (chunk, final) {\n        if (!this.ondata)\n            err(5);\n        if (this.d)\n            err(4);\n        this.d = final;\n        this.p(chunk, final || false);\n    };\n    return Deflate;\n}());\nexport { Deflate };\n/**\n * Asynchronous streaming DEFLATE compression\n */\nvar AsyncDeflate = /*#__PURE__*/ (function () {\n    function AsyncDeflate(opts, cb) {\n        astrmify([\n            bDflt,\n            function () { return [astrm, Deflate]; }\n        ], this, AsyncCmpStrm.call(this, opts, cb), function (ev) {\n            var strm = new Deflate(ev.data);\n            onmessage = astrm(strm);\n        }, 6);\n    }\n    return AsyncDeflate;\n}());\nexport { AsyncDeflate };\nexport function deflate(data, opts, cb) {\n    if (!cb)\n        cb = opts, opts = {};\n    if (typeof cb != 'function')\n        err(7);\n    return cbify(data, opts, [\n        bDflt,\n    ], function (ev) { return pbf(deflateSync(ev.data[0], ev.data[1])); }, 0, cb);\n}\n/**\n * Compresses data with DEFLATE without any wrapper\n * @param data The data to compress\n * @param opts The compression options\n * @returns The deflated version of the data\n */\nexport function deflateSync(data, opts) {\n    return dopt(data, opts || {}, 0, 0);\n}\n/**\n * Streaming DEFLATE decompression\n */\nvar Inflate = /*#__PURE__*/ (function () {\n    /**\n     * Creates an inflation stream\n     * @param cb The callback to call whenever data is inflated\n     */\n    function Inflate(cb) {\n        this.s = {};\n        this.p = new u8(0);\n        this.ondata = cb;\n    }\n    Inflate.prototype.e = function (c) {\n        if (!this.ondata)\n            err(5);\n        if (this.d)\n            err(4);\n        var l = this.p.length;\n        var n = new u8(l + c.length);\n        n.set(this.p), n.set(c, l), this.p = n;\n    };\n    Inflate.prototype.c = function (final) {\n        this.d = this.s.i = final || false;\n        var bts = this.s.b;\n        var dt = inflt(this.p, this.o, this.s);\n        this.ondata(slc(dt, bts, this.s.b), this.d);\n        this.o = slc(dt, this.s.b - 32768), this.s.b = this.o.length;\n        this.p = slc(this.p, (this.s.p / 8) | 0), this.s.p &= 7;\n    };\n    /**\n     * Pushes a chunk to be inflated\n     * @param chunk The chunk to push\n     * @param final Whether this is the final chunk\n     */\n    Inflate.prototype.push = function (chunk, final) {\n        this.e(chunk), this.c(final);\n    };\n    return Inflate;\n}());\nexport { Inflate };\n/**\n * Asynchronous streaming DEFLATE decompression\n */\nvar AsyncInflate = /*#__PURE__*/ (function () {\n    /**\n     * Creates an asynchronous inflation stream\n     * @param cb The callback to call whenever data is deflated\n     */\n    function AsyncInflate(cb) {\n        this.ondata = cb;\n        astrmify([\n            bInflt,\n            function () { return [astrm, Inflate]; }\n        ], this, 0, function () {\n            var strm = new Inflate();\n            onmessage = astrm(strm);\n        }, 7);\n    }\n    return AsyncInflate;\n}());\nexport { AsyncInflate };\nexport function inflate(data, opts, cb) {\n    if (!cb)\n        cb = opts, opts = {};\n    if (typeof cb != 'function')\n        err(7);\n    return cbify(data, opts, [\n        bInflt\n    ], function (ev) { return pbf(inflateSync(ev.data[0], gu8(ev.data[1]))); }, 1, cb);\n}\n/**\n * Expands DEFLATE data with no wrapper\n * @param data The data to decompress\n * @param out Where to write the data. Saves memory if you know the decompressed size and provide an output buffer of that length.\n * @returns The decompressed version of the data\n */\nexport function inflateSync(data, out) {\n    return inflt(data, out);\n}\n// before you yell at me for not just using extends, my reason is that TS inheritance is hard to workerize.\n/**\n * Streaming GZIP compression\n */\nvar Gzip = /*#__PURE__*/ (function () {\n    function Gzip(opts, cb) {\n        this.c = crc();\n        this.l = 0;\n        this.v = 1;\n        Deflate.call(this, opts, cb);\n    }\n    /**\n     * Pushes a chunk to be GZIPped\n     * @param chunk The chunk to push\n     * @param final Whether this is the last chunk\n     */\n    Gzip.prototype.push = function (chunk, final) {\n        Deflate.prototype.push.call(this, chunk, final);\n    };\n    Gzip.prototype.p = function (c, f) {\n        this.c.p(c);\n        this.l += c.length;\n        var raw = dopt(c, this.o, this.v && gzhl(this.o), f && 8, !f);\n        if (this.v)\n            gzh(raw, this.o), this.v = 0;\n        if (f)\n            wbytes(raw, raw.length - 8, this.c.d()), wbytes(raw, raw.length - 4, this.l);\n        this.ondata(raw, f);\n    };\n    return Gzip;\n}());\nexport { Gzip };\n/**\n * Asynchronous streaming GZIP compression\n */\nvar AsyncGzip = /*#__PURE__*/ (function () {\n    function AsyncGzip(opts, cb) {\n        astrmify([\n            bDflt,\n            gze,\n            function () { return [astrm, Deflate, Gzip]; }\n        ], this, AsyncCmpStrm.call(this, opts, cb), function (ev) {\n            var strm = new Gzip(ev.data);\n            onmessage = astrm(strm);\n        }, 8);\n    }\n    return AsyncGzip;\n}());\nexport { AsyncGzip };\nexport function gzip(data, opts, cb) {\n    if (!cb)\n        cb = opts, opts = {};\n    if (typeof cb != 'function')\n        err(7);\n    return cbify(data, opts, [\n        bDflt,\n        gze,\n        function () { return [gzipSync]; }\n    ], function (ev) { return pbf(gzipSync(ev.data[0], ev.data[1])); }, 2, cb);\n}\n/**\n * Compresses data with GZIP\n * @param data The data to compress\n * @param opts The compression options\n * @returns The gzipped version of the data\n */\nexport function gzipSync(data, opts) {\n    if (!opts)\n        opts = {};\n    var c = crc(), l = data.length;\n    c.p(data);\n    var d = dopt(data, opts, gzhl(opts), 8), s = d.length;\n    return gzh(d, opts), wbytes(d, s - 8, c.d()), wbytes(d, s - 4, l), d;\n}\n/**\n * Streaming GZIP decompression\n */\nvar Gunzip = /*#__PURE__*/ (function () {\n    /**\n     * Creates a GUNZIP stream\n     * @param cb The callback to call whenever data is inflated\n     */\n    function Gunzip(cb) {\n        this.v = 1;\n        Inflate.call(this, cb);\n    }\n    /**\n     * Pushes a chunk to be GUNZIPped\n     * @param chunk The chunk to push\n     * @param final Whether this is the last chunk\n     */\n    Gunzip.prototype.push = function (chunk, final) {\n        Inflate.prototype.e.call(this, chunk);\n        if (this.v) {\n            var s = this.p.length > 3 ? gzs(this.p) : 4;\n            if (s >= this.p.length && !final)\n                return;\n            this.p = this.p.subarray(s), this.v = 0;\n        }\n        if (final) {\n            if (this.p.length < 8)\n                err(6, 'invalid gzip data');\n            this.p = this.p.subarray(0, -8);\n        }\n        // necessary to prevent TS from using the closure value\n        // This allows for workerization to function correctly\n        Inflate.prototype.c.call(this, final);\n    };\n    return Gunzip;\n}());\nexport { Gunzip };\n/**\n * Asynchronous streaming GZIP decompression\n */\nvar AsyncGunzip = /*#__PURE__*/ (function () {\n    /**\n     * Creates an asynchronous GUNZIP stream\n     * @param cb The callback to call whenever data is deflated\n     */\n    function AsyncGunzip(cb) {\n        this.ondata = cb;\n        astrmify([\n            bInflt,\n            guze,\n            function () { return [astrm, Inflate, Gunzip]; }\n        ], this, 0, function () {\n            var strm = new Gunzip();\n            onmessage = astrm(strm);\n        }, 9);\n    }\n    return AsyncGunzip;\n}());\nexport { AsyncGunzip };\nexport function gunzip(data, opts, cb) {\n    if (!cb)\n        cb = opts, opts = {};\n    if (typeof cb != 'function')\n        err(7);\n    return cbify(data, opts, [\n        bInflt,\n        guze,\n        function () { return [gunzipSync]; }\n    ], function (ev) { return pbf(gunzipSync(ev.data[0])); }, 3, cb);\n}\n/**\n * Expands GZIP data\n * @param data The data to decompress\n * @param out Where to write the data. GZIP already encodes the output size, so providing this doesn't save memory.\n * @returns The decompressed version of the data\n */\nexport function gunzipSync(data, out) {\n    return inflt(data.subarray(gzs(data), -8), out || new u8(gzl(data)));\n}\n/**\n * Streaming Zlib compression\n */\nvar Zlib = /*#__PURE__*/ (function () {\n    function Zlib(opts, cb) {\n        this.c = adler();\n        this.v = 1;\n        Deflate.call(this, opts, cb);\n    }\n    /**\n     * Pushes a chunk to be zlibbed\n     * @param chunk The chunk to push\n     * @param final Whether this is the last chunk\n     */\n    Zlib.prototype.push = function (chunk, final) {\n        Deflate.prototype.push.call(this, chunk, final);\n    };\n    Zlib.prototype.p = function (c, f) {\n        this.c.p(c);\n        var raw = dopt(c, this.o, this.v && 2, f && 4, !f);\n        if (this.v)\n            zlh(raw, this.o), this.v = 0;\n        if (f)\n            wbytes(raw, raw.length - 4, this.c.d());\n        this.ondata(raw, f);\n    };\n    return Zlib;\n}());\nexport { Zlib };\n/**\n * Asynchronous streaming Zlib compression\n */\nvar AsyncZlib = /*#__PURE__*/ (function () {\n    function AsyncZlib(opts, cb) {\n        astrmify([\n            bDflt,\n            zle,\n            function () { return [astrm, Deflate, Zlib]; }\n        ], this, AsyncCmpStrm.call(this, opts, cb), function (ev) {\n            var strm = new Zlib(ev.data);\n            onmessage = astrm(strm);\n        }, 10);\n    }\n    return AsyncZlib;\n}());\nexport { AsyncZlib };\nexport function zlib(data, opts, cb) {\n    if (!cb)\n        cb = opts, opts = {};\n    if (typeof cb != 'function')\n        err(7);\n    return cbify(data, opts, [\n        bDflt,\n        zle,\n        function () { return [zlibSync]; }\n    ], function (ev) { return pbf(zlibSync(ev.data[0], ev.data[1])); }, 4, cb);\n}\n/**\n * Compress data with Zlib\n * @param data The data to compress\n * @param opts The compression options\n * @returns The zlib-compressed version of the data\n */\nexport function zlibSync(data, opts) {\n    if (!opts)\n        opts = {};\n    var a = adler();\n    a.p(data);\n    var d = dopt(data, opts, 2, 4);\n    return zlh(d, opts), wbytes(d, d.length - 4, a.d()), d;\n}\n/**\n * Streaming Zlib decompression\n */\nvar Unzlib = /*#__PURE__*/ (function () {\n    /**\n     * Creates a Zlib decompression stream\n     * @param cb The callback to call whenever data is inflated\n     */\n    function Unzlib(cb) {\n        this.v = 1;\n        Inflate.call(this, cb);\n    }\n    /**\n     * Pushes a chunk to be unzlibbed\n     * @param chunk The chunk to push\n     * @param final Whether this is the last chunk\n     */\n    Unzlib.prototype.push = function (chunk, final) {\n        Inflate.prototype.e.call(this, chunk);\n        if (this.v) {\n            if (this.p.length < 2 && !final)\n                return;\n            this.p = this.p.subarray(2), this.v = 0;\n        }\n        if (final) {\n            if (this.p.length < 4)\n                err(6, 'invalid zlib data');\n            this.p = this.p.subarray(0, -4);\n        }\n        // necessary to prevent TS from using the closure value\n        // This allows for workerization to function correctly\n        Inflate.prototype.c.call(this, final);\n    };\n    return Unzlib;\n}());\nexport { Unzlib };\n/**\n * Asynchronous streaming Zlib decompression\n */\nvar AsyncUnzlib = /*#__PURE__*/ (function () {\n    /**\n     * Creates an asynchronous Zlib decompression stream\n     * @param cb The callback to call whenever data is deflated\n     */\n    function AsyncUnzlib(cb) {\n        this.ondata = cb;\n        astrmify([\n            bInflt,\n            zule,\n            function () { return [astrm, Inflate, Unzlib]; }\n        ], this, 0, function () {\n            var strm = new Unzlib();\n            onmessage = astrm(strm);\n        }, 11);\n    }\n    return AsyncUnzlib;\n}());\nexport { AsyncUnzlib };\nexport function unzlib(data, opts, cb) {\n    if (!cb)\n        cb = opts, opts = {};\n    if (typeof cb != 'function')\n        err(7);\n    return cbify(data, opts, [\n        bInflt,\n        zule,\n        function () { return [unzlibSync]; }\n    ], function (ev) { return pbf(unzlibSync(ev.data[0], gu8(ev.data[1]))); }, 5, cb);\n}\n/**\n * Expands Zlib data\n * @param data The data to decompress\n * @param out Where to write the data. Saves memory if you know the decompressed size and provide an output buffer of that length.\n * @returns The decompressed version of the data\n */\nexport function unzlibSync(data, out) {\n    return inflt((zlv(data), data.subarray(2, -4)), out);\n}\n// Default algorithm for compression (used because having a known output size allows faster decompression)\nexport { gzip as compress, AsyncGzip as AsyncCompress };\n// Default algorithm for compression (used because having a known output size allows faster decompression)\nexport { gzipSync as compressSync, Gzip as Compress };\n/**\n * Streaming GZIP, Zlib, or raw DEFLATE decompression\n */\nvar Decompress = /*#__PURE__*/ (function () {\n    /**\n     * Creates a decompression stream\n     * @param cb The callback to call whenever data is decompressed\n     */\n    function Decompress(cb) {\n        this.G = Gunzip;\n        this.I = Inflate;\n        this.Z = Unzlib;\n        this.ondata = cb;\n    }\n    /**\n     * Pushes a chunk to be decompressed\n     * @param chunk The chunk to push\n     * @param final Whether this is the last chunk\n     */\n    Decompress.prototype.push = function (chunk, final) {\n        if (!this.ondata)\n            err(5);\n        if (!this.s) {\n            if (this.p && this.p.length) {\n                var n = new u8(this.p.length + chunk.length);\n                n.set(this.p), n.set(chunk, this.p.length);\n            }\n            else\n                this.p = chunk;\n            if (this.p.length > 2) {\n                var _this_1 = this;\n                var cb = function () { _this_1.ondata.apply(_this_1, arguments); };\n                this.s = (this.p[0] == 31 && this.p[1] == 139 && this.p[2] == 8)\n                    ? new this.G(cb)\n                    : ((this.p[0] & 15) != 8 || (this.p[0] >> 4) > 7 || ((this.p[0] << 8 | this.p[1]) % 31))\n                        ? new this.I(cb)\n                        : new this.Z(cb);\n                this.s.push(this.p, final);\n                this.p = null;\n            }\n        }\n        else\n            this.s.push(chunk, final);\n    };\n    return Decompress;\n}());\nexport { Decompress };\n/**\n * Asynchronous streaming GZIP, Zlib, or raw DEFLATE decompression\n */\nvar AsyncDecompress = /*#__PURE__*/ (function () {\n    /**\n   * Creates an asynchronous decompression stream\n   * @param cb The callback to call whenever data is decompressed\n   */\n    function AsyncDecompress(cb) {\n        this.G = AsyncGunzip;\n        this.I = AsyncInflate;\n        this.Z = AsyncUnzlib;\n        this.ondata = cb;\n    }\n    /**\n     * Pushes a chunk to be decompressed\n     * @param chunk The chunk to push\n     * @param final Whether this is the last chunk\n     */\n    AsyncDecompress.prototype.push = function (chunk, final) {\n        Decompress.prototype.push.call(this, chunk, final);\n    };\n    return AsyncDecompress;\n}());\nexport { AsyncDecompress };\nexport function decompress(data, opts, cb) {\n    if (!cb)\n        cb = opts, opts = {};\n    if (typeof cb != 'function')\n        err(7);\n    return (data[0] == 31 && data[1] == 139 && data[2] == 8)\n        ? gunzip(data, opts, cb)\n        : ((data[0] & 15) != 8 || (data[0] >> 4) > 7 || ((data[0] << 8 | data[1]) % 31))\n            ? inflate(data, opts, cb)\n            : unzlib(data, opts, cb);\n}\n/**\n * Expands compressed GZIP, Zlib, or raw DEFLATE data, automatically detecting the format\n * @param data The data to decompress\n * @param out Where to write the data. Saves memory if you know the decompressed size and provide an output buffer of that length.\n * @returns The decompressed version of the data\n */\nexport function decompressSync(data, out) {\n    return (data[0] == 31 && data[1] == 139 && data[2] == 8)\n        ? gunzipSync(data, out)\n        : ((data[0] & 15) != 8 || (data[0] >> 4) > 7 || ((data[0] << 8 | data[1]) % 31))\n            ? inflateSync(data, out)\n            : unzlibSync(data, out);\n}\n// flatten a directory structure\nvar fltn = function (d, p, t, o) {\n    for (var k in d) {\n        var val = d[k], n = p + k, op = o;\n        if (Array.isArray(val))\n            op = mrg(o, val[1]), val = val[0];\n        if (val instanceof u8)\n            t[n] = [val, op];\n        else {\n            t[n += '/'] = [new u8(0), op];\n            fltn(val, n, t, o);\n        }\n    }\n};\n// text encoder\nvar te = typeof TextEncoder != 'undefined' && /*#__PURE__*/ new TextEncoder();\n// text decoder\nvar td = typeof TextDecoder != 'undefined' && /*#__PURE__*/ new TextDecoder();\n// text decoder stream\nvar tds = 0;\ntry {\n    td.decode(et, { stream: true });\n    tds = 1;\n}\ncatch (e) { }\n// decode UTF8\nvar dutf8 = function (d) {\n    for (var r = '', i = 0;;) {\n        var c = d[i++];\n        var eb = (c > 127) + (c > 223) + (c > 239);\n        if (i + eb > d.length)\n            return [r, slc(d, i - 1)];\n        if (!eb)\n            r += String.fromCharCode(c);\n        else if (eb == 3) {\n            c = ((c & 15) << 18 | (d[i++] & 63) << 12 | (d[i++] & 63) << 6 | (d[i++] & 63)) - 65536,\n                r += String.fromCharCode(55296 | (c >> 10), 56320 | (c & 1023));\n        }\n        else if (eb & 1)\n            r += String.fromCharCode((c & 31) << 6 | (d[i++] & 63));\n        else\n            r += String.fromCharCode((c & 15) << 12 | (d[i++] & 63) << 6 | (d[i++] & 63));\n    }\n};\n/**\n * Streaming UTF-8 decoding\n */\nvar DecodeUTF8 = /*#__PURE__*/ (function () {\n    /**\n     * Creates a UTF-8 decoding stream\n     * @param cb The callback to call whenever data is decoded\n     */\n    function DecodeUTF8(cb) {\n        this.ondata = cb;\n        if (tds)\n            this.t = new TextDecoder();\n        else\n            this.p = et;\n    }\n    /**\n     * Pushes a chunk to be decoded from UTF-8 binary\n     * @param chunk The chunk to push\n     * @param final Whether this is the last chunk\n     */\n    DecodeUTF8.prototype.push = function (chunk, final) {\n        if (!this.ondata)\n            err(5);\n        final = !!final;\n        if (this.t) {\n            this.ondata(this.t.decode(chunk, { stream: true }), final);\n            if (final) {\n                if (this.t.decode().length)\n                    err(8);\n                this.t = null;\n            }\n            return;\n        }\n        if (!this.p)\n            err(4);\n        var dat = new u8(this.p.length + chunk.length);\n        dat.set(this.p);\n        dat.set(chunk, this.p.length);\n        var _a = dutf8(dat), ch = _a[0], np = _a[1];\n        if (final) {\n            if (np.length)\n                err(8);\n            this.p = null;\n        }\n        else\n            this.p = np;\n        this.ondata(ch, final);\n    };\n    return DecodeUTF8;\n}());\nexport { DecodeUTF8 };\n/**\n * Streaming UTF-8 encoding\n */\nvar EncodeUTF8 = /*#__PURE__*/ (function () {\n    /**\n     * Creates a UTF-8 decoding stream\n     * @param cb The callback to call whenever data is encoded\n     */\n    function EncodeUTF8(cb) {\n        this.ondata = cb;\n    }\n    /**\n     * Pushes a chunk to be encoded to UTF-8\n     * @param chunk The string data to push\n     * @param final Whether this is the last chunk\n     */\n    EncodeUTF8.prototype.push = function (chunk, final) {\n        if (!this.ondata)\n            err(5);\n        if (this.d)\n            err(4);\n        this.ondata(strToU8(chunk), this.d = final || false);\n    };\n    return EncodeUTF8;\n}());\nexport { EncodeUTF8 };\n/**\n * Converts a string into a Uint8Array for use with compression/decompression methods\n * @param str The string to encode\n * @param latin1 Whether or not to interpret the data as Latin-1. This should\n *               not need to be true unless decoding a binary string.\n * @returns The string encoded in UTF-8/Latin-1 binary\n */\nexport function strToU8(str, latin1) {\n    if (latin1) {\n        var ar_1 = new u8(str.length);\n        for (var i = 0; i < str.length; ++i)\n            ar_1[i] = str.charCodeAt(i);\n        return ar_1;\n    }\n    if (te)\n        return te.encode(str);\n    var l = str.length;\n    var ar = new u8(str.length + (str.length >> 1));\n    var ai = 0;\n    var w = function (v) { ar[ai++] = v; };\n    for (var i = 0; i < l; ++i) {\n        if (ai + 5 > ar.length) {\n            var n = new u8(ai + 8 + ((l - i) << 1));\n            n.set(ar);\n            ar = n;\n        }\n        var c = str.charCodeAt(i);\n        if (c < 128 || latin1)\n            w(c);\n        else if (c < 2048)\n            w(192 | (c >> 6)), w(128 | (c & 63));\n        else if (c > 55295 && c < 57344)\n            c = 65536 + (c & 1023 << 10) | (str.charCodeAt(++i) & 1023),\n                w(240 | (c >> 18)), w(128 | ((c >> 12) & 63)), w(128 | ((c >> 6) & 63)), w(128 | (c & 63));\n        else\n            w(224 | (c >> 12)), w(128 | ((c >> 6) & 63)), w(128 | (c & 63));\n    }\n    return slc(ar, 0, ai);\n}\n/**\n * Converts a Uint8Array to a string\n * @param dat The data to decode to string\n * @param latin1 Whether or not to interpret the data as Latin-1. This should\n *               not need to be true unless encoding to binary string.\n * @returns The original UTF-8/Latin-1 string\n */\nexport function strFromU8(dat, latin1) {\n    if (latin1) {\n        var r = '';\n        for (var i = 0; i < dat.length; i += 16384)\n            r += String.fromCharCode.apply(null, dat.subarray(i, i + 16384));\n        return r;\n    }\n    else if (td)\n        return td.decode(dat);\n    else {\n        var _a = dutf8(dat), out = _a[0], ext = _a[1];\n        if (ext.length)\n            err(8);\n        return out;\n    }\n}\n;\n// deflate bit flag\nvar dbf = function (l) { return l == 1 ? 3 : l < 6 ? 2 : l == 9 ? 1 : 0; };\n// skip local zip header\nvar slzh = function (d, b) { return b + 30 + b2(d, b + 26) + b2(d, b + 28); };\n// read zip header\nvar zh = function (d, b, z) {\n    var fnl = b2(d, b + 28), fn = strFromU8(d.subarray(b + 46, b + 46 + fnl), !(b2(d, b + 8) & 2048)), es = b + 46 + fnl, bs = b4(d, b + 20);\n    var _a = z && bs == 4294967295 ? z64e(d, es) : [bs, b4(d, b + 24), b4(d, b + 42)], sc = _a[0], su = _a[1], off = _a[2];\n    return [b2(d, b + 10), sc, su, fn, es + b2(d, b + 30) + b2(d, b + 32), off];\n};\n// read zip64 extra field\nvar z64e = function (d, b) {\n    for (; b2(d, b) != 1; b += 4 + b2(d, b + 2))\n        ;\n    return [b8(d, b + 12), b8(d, b + 4), b8(d, b + 20)];\n};\n// extra field length\nvar exfl = function (ex) {\n    var le = 0;\n    if (ex) {\n        for (var k in ex) {\n            var l = ex[k].length;\n            if (l > 65535)\n                err(9);\n            le += l + 4;\n        }\n    }\n    return le;\n};\n// write zip header\nvar wzh = function (d, b, f, fn, u, c, ce, co) {\n    var fl = fn.length, ex = f.extra, col = co && co.length;\n    var exl = exfl(ex);\n    wbytes(d, b, ce != null ? 0x2014B50 : 0x4034B50), b += 4;\n    if (ce != null)\n        d[b++] = 20, d[b++] = f.os;\n    d[b] = 20, b += 2; // spec compliance? what's that?\n    d[b++] = (f.flag << 1) | (c == null && 8), d[b++] = u && 8;\n    d[b++] = f.compression & 255, d[b++] = f.compression >> 8;\n    var dt = new Date(f.mtime == null ? Date.now() : f.mtime), y = dt.getFullYear() - 1980;\n    if (y < 0 || y > 119)\n        err(10);\n    wbytes(d, b, (y << 25) | ((dt.getMonth() + 1) << 21) | (dt.getDate() << 16) | (dt.getHours() << 11) | (dt.getMinutes() << 5) | (dt.getSeconds() >>> 1)), b += 4;\n    if (c != null) {\n        wbytes(d, b, f.crc);\n        wbytes(d, b + 4, c);\n        wbytes(d, b + 8, f.size);\n    }\n    wbytes(d, b + 12, fl);\n    wbytes(d, b + 14, exl), b += 16;\n    if (ce != null) {\n        wbytes(d, b, col);\n        wbytes(d, b + 6, f.attrs);\n        wbytes(d, b + 10, ce), b += 14;\n    }\n    d.set(fn, b);\n    b += fl;\n    if (exl) {\n        for (var k in ex) {\n            var exf = ex[k], l = exf.length;\n            wbytes(d, b, +k);\n            wbytes(d, b + 2, l);\n            d.set(exf, b + 4), b += 4 + l;\n        }\n    }\n    if (col)\n        d.set(co, b), b += col;\n    return b;\n};\n// write zip footer (end of central directory)\nvar wzf = function (o, b, c, d, e) {\n    wbytes(o, b, 0x6054B50); // skip disk\n    wbytes(o, b + 8, c);\n    wbytes(o, b + 10, c);\n    wbytes(o, b + 12, d);\n    wbytes(o, b + 16, e);\n};\n/**\n * A pass-through stream to keep data uncompressed in a ZIP archive.\n */\nvar ZipPassThrough = /*#__PURE__*/ (function () {\n    /**\n     * Creates a pass-through stream that can be added to ZIP archives\n     * @param filename The filename to associate with this data stream\n     */\n    function ZipPassThrough(filename) {\n        this.filename = filename;\n        this.c = crc();\n        this.size = 0;\n        this.compression = 0;\n    }\n    /**\n     * Processes a chunk and pushes to the output stream. You can override this\n     * method in a subclass for custom behavior, but by default this passes\n     * the data through. You must call this.ondata(err, chunk, final) at some\n     * point in this method.\n     * @param chunk The chunk to process\n     * @param final Whether this is the last chunk\n     */\n    ZipPassThrough.prototype.process = function (chunk, final) {\n        this.ondata(null, chunk, final);\n    };\n    /**\n     * Pushes a chunk to be added. If you are subclassing this with a custom\n     * compression algorithm, note that you must push data from the source\n     * file only, pre-compression.\n     * @param chunk The chunk to push\n     * @param final Whether this is the last chunk\n     */\n    ZipPassThrough.prototype.push = function (chunk, final) {\n        if (!this.ondata)\n            err(5);\n        this.c.p(chunk);\n        this.size += chunk.length;\n        if (final)\n            this.crc = this.c.d();\n        this.process(chunk, final || false);\n    };\n    return ZipPassThrough;\n}());\nexport { ZipPassThrough };\n// I don't extend because TypeScript extension adds 1kB of runtime bloat\n/**\n * Streaming DEFLATE compression for ZIP archives. Prefer using AsyncZipDeflate\n * for better performance\n */\nvar ZipDeflate = /*#__PURE__*/ (function () {\n    /**\n     * Creates a DEFLATE stream that can be added to ZIP archives\n     * @param filename The filename to associate with this data stream\n     * @param opts The compression options\n     */\n    function ZipDeflate(filename, opts) {\n        var _this_1 = this;\n        if (!opts)\n            opts = {};\n        ZipPassThrough.call(this, filename);\n        this.d = new Deflate(opts, function (dat, final) {\n            _this_1.ondata(null, dat, final);\n        });\n        this.compression = 8;\n        this.flag = dbf(opts.level);\n    }\n    ZipDeflate.prototype.process = function (chunk, final) {\n        try {\n            this.d.push(chunk, final);\n        }\n        catch (e) {\n            this.ondata(e, null, final);\n        }\n    };\n    /**\n     * Pushes a chunk to be deflated\n     * @param chunk The chunk to push\n     * @param final Whether this is the last chunk\n     */\n    ZipDeflate.prototype.push = function (chunk, final) {\n        ZipPassThrough.prototype.push.call(this, chunk, final);\n    };\n    return ZipDeflate;\n}());\nexport { ZipDeflate };\n/**\n * Asynchronous streaming DEFLATE compression for ZIP archives\n */\nvar AsyncZipDeflate = /*#__PURE__*/ (function () {\n    /**\n     * Creates a DEFLATE stream that can be added to ZIP archives\n     * @param filename The filename to associate with this data stream\n     * @param opts The compression options\n     */\n    function AsyncZipDeflate(filename, opts) {\n        var _this_1 = this;\n        if (!opts)\n            opts = {};\n        ZipPassThrough.call(this, filename);\n        this.d = new AsyncDeflate(opts, function (err, dat, final) {\n            _this_1.ondata(err, dat, final);\n        });\n        this.compression = 8;\n        this.flag = dbf(opts.level);\n        this.terminate = this.d.terminate;\n    }\n    AsyncZipDeflate.prototype.process = function (chunk, final) {\n        this.d.push(chunk, final);\n    };\n    /**\n     * Pushes a chunk to be deflated\n     * @param chunk The chunk to push\n     * @param final Whether this is the last chunk\n     */\n    AsyncZipDeflate.prototype.push = function (chunk, final) {\n        ZipPassThrough.prototype.push.call(this, chunk, final);\n    };\n    return AsyncZipDeflate;\n}());\nexport { AsyncZipDeflate };\n// TODO: Better tree shaking\n/**\n * A zippable archive to which files can incrementally be added\n */\nvar Zip = /*#__PURE__*/ (function () {\n    /**\n     * Creates an empty ZIP archive to which files can be added\n     * @param cb The callback to call whenever data for the generated ZIP archive\n     *           is available\n     */\n    function Zip(cb) {\n        this.ondata = cb;\n        this.u = [];\n        this.d = 1;\n    }\n    /**\n     * Adds a file to the ZIP archive\n     * @param file The file stream to add\n     */\n    Zip.prototype.add = function (file) {\n        var _this_1 = this;\n        if (!this.ondata)\n            err(5);\n        // finishing or finished\n        if (this.d & 2)\n            this.ondata(err(4 + (this.d & 1) * 8, 0, 1), null, false);\n        else {\n            var f = strToU8(file.filename), fl_1 = f.length;\n            var com = file.comment, o = com && strToU8(com);\n            var u = fl_1 != file.filename.length || (o && (com.length != o.length));\n            var hl_1 = fl_1 + exfl(file.extra) + 30;\n            if (fl_1 > 65535)\n                this.ondata(err(11, 0, 1), null, false);\n            var header = new u8(hl_1);\n            wzh(header, 0, file, f, u);\n            var chks_1 = [header];\n            var pAll_1 = function () {\n                for (var _i = 0, chks_2 = chks_1; _i < chks_2.length; _i++) {\n                    var chk = chks_2[_i];\n                    _this_1.ondata(null, chk, false);\n                }\n                chks_1 = [];\n            };\n            var tr_1 = this.d;\n            this.d = 0;\n            var ind_1 = this.u.length;\n            var uf_1 = mrg(file, {\n                f: f,\n                u: u,\n                o: o,\n                t: function () {\n                    if (file.terminate)\n                        file.terminate();\n                },\n                r: function () {\n                    pAll_1();\n                    if (tr_1) {\n                        var nxt = _this_1.u[ind_1 + 1];\n                        if (nxt)\n                            nxt.r();\n                        else\n                            _this_1.d = 1;\n                    }\n                    tr_1 = 1;\n                }\n            });\n            var cl_1 = 0;\n            file.ondata = function (err, dat, final) {\n                if (err) {\n                    _this_1.ondata(err, dat, final);\n                    _this_1.terminate();\n                }\n                else {\n                    cl_1 += dat.length;\n                    chks_1.push(dat);\n                    if (final) {\n                        var dd = new u8(16);\n                        wbytes(dd, 0, 0x8074B50);\n                        wbytes(dd, 4, file.crc);\n                        wbytes(dd, 8, cl_1);\n                        wbytes(dd, 12, file.size);\n                        chks_1.push(dd);\n                        uf_1.c = cl_1, uf_1.b = hl_1 + cl_1 + 16, uf_1.crc = file.crc, uf_1.size = file.size;\n                        if (tr_1)\n                            uf_1.r();\n                        tr_1 = 1;\n                    }\n                    else if (tr_1)\n                        pAll_1();\n                }\n            };\n            this.u.push(uf_1);\n        }\n    };\n    /**\n     * Ends the process of adding files and prepares to emit the final chunks.\n     * This *must* be called after adding all desired files for the resulting\n     * ZIP file to work properly.\n     */\n    Zip.prototype.end = function () {\n        var _this_1 = this;\n        if (this.d & 2) {\n            this.ondata(err(4 + (this.d & 1) * 8, 0, 1), null, true);\n            return;\n        }\n        if (this.d)\n            this.e();\n        else\n            this.u.push({\n                r: function () {\n                    if (!(_this_1.d & 1))\n                        return;\n                    _this_1.u.splice(-1, 1);\n                    _this_1.e();\n                },\n                t: function () { }\n            });\n        this.d = 3;\n    };\n    Zip.prototype.e = function () {\n        var bt = 0, l = 0, tl = 0;\n        for (var _i = 0, _a = this.u; _i < _a.length; _i++) {\n            var f = _a[_i];\n            tl += 46 + f.f.length + exfl(f.extra) + (f.o ? f.o.length : 0);\n        }\n        var out = new u8(tl + 22);\n        for (var _b = 0, _c = this.u; _b < _c.length; _b++) {\n            var f = _c[_b];\n            wzh(out, bt, f, f.f, f.u, f.c, l, f.o);\n            bt += 46 + f.f.length + exfl(f.extra) + (f.o ? f.o.length : 0), l += f.b;\n        }\n        wzf(out, bt, this.u.length, tl, l);\n        this.ondata(null, out, true);\n        this.d = 2;\n    };\n    /**\n     * A method to terminate any internal workers used by the stream. Subsequent\n     * calls to add() will fail.\n     */\n    Zip.prototype.terminate = function () {\n        for (var _i = 0, _a = this.u; _i < _a.length; _i++) {\n            var f = _a[_i];\n            f.t();\n        }\n        this.d = 2;\n    };\n    return Zip;\n}());\nexport { Zip };\nexport function zip(data, opts, cb) {\n    if (!cb)\n        cb = opts, opts = {};\n    if (typeof cb != 'function')\n        err(7);\n    var r = {};\n    fltn(data, '', r, opts);\n    var k = Object.keys(r);\n    var lft = k.length, o = 0, tot = 0;\n    var slft = lft, files = new Array(lft);\n    var term = [];\n    var tAll = function () {\n        for (var i = 0; i < term.length; ++i)\n            term[i]();\n    };\n    var cbd = function (a, b) {\n        mt(function () { cb(a, b); });\n    };\n    mt(function () { cbd = cb; });\n    var cbf = function () {\n        var out = new u8(tot + 22), oe = o, cdl = tot - o;\n        tot = 0;\n        for (var i = 0; i < slft; ++i) {\n            var f = files[i];\n            try {\n                var l = f.c.length;\n                wzh(out, tot, f, f.f, f.u, l);\n                var badd = 30 + f.f.length + exfl(f.extra);\n                var loc = tot + badd;\n                out.set(f.c, loc);\n                wzh(out, o, f, f.f, f.u, l, tot, f.m), o += 16 + badd + (f.m ? f.m.length : 0), tot = loc + l;\n            }\n            catch (e) {\n                return cbd(e, null);\n            }\n        }\n        wzf(out, o, files.length, cdl, oe);\n        cbd(null, out);\n    };\n    if (!lft)\n        cbf();\n    var _loop_1 = function (i) {\n        var fn = k[i];\n        var _a = r[fn], file = _a[0], p = _a[1];\n        var c = crc(), size = file.length;\n        c.p(file);\n        var f = strToU8(fn), s = f.length;\n        var com = p.comment, m = com && strToU8(com), ms = m && m.length;\n        var exl = exfl(p.extra);\n        var compression = p.level == 0 ? 0 : 8;\n        var cbl = function (e, d) {\n            if (e) {\n                tAll();\n                cbd(e, null);\n            }\n            else {\n                var l = d.length;\n                files[i] = mrg(p, {\n                    size: size,\n                    crc: c.d(),\n                    c: d,\n                    f: f,\n                    m: m,\n                    u: s != fn.length || (m && (com.length != ms)),\n                    compression: compression\n                });\n                o += 30 + s + exl + l;\n                tot += 76 + 2 * (s + exl) + (ms || 0) + l;\n                if (!--lft)\n                    cbf();\n            }\n        };\n        if (s > 65535)\n            cbl(err(11, 0, 1), null);\n        if (!compression)\n            cbl(null, file);\n        else if (size < 160000) {\n            try {\n                cbl(null, deflateSync(file, p));\n            }\n            catch (e) {\n                cbl(e, null);\n            }\n        }\n        else\n            term.push(deflate(file, p, cbl));\n    };\n    // Cannot use lft because it can decrease\n    for (var i = 0; i < slft; ++i) {\n        _loop_1(i);\n    }\n    return tAll;\n}\n/**\n * Synchronously creates a ZIP file. Prefer using `zip` for better performance\n * with more than one file.\n * @param data The directory structure for the ZIP archive\n * @param opts The main options, merged with per-file options\n * @returns The generated ZIP archive\n */\nexport function zipSync(data, opts) {\n    if (!opts)\n        opts = {};\n    var r = {};\n    var files = [];\n    fltn(data, '', r, opts);\n    var o = 0;\n    var tot = 0;\n    for (var fn in r) {\n        var _a = r[fn], file = _a[0], p = _a[1];\n        var compression = p.level == 0 ? 0 : 8;\n        var f = strToU8(fn), s = f.length;\n        var com = p.comment, m = com && strToU8(com), ms = m && m.length;\n        var exl = exfl(p.extra);\n        if (s > 65535)\n            err(11);\n        var d = compression ? deflateSync(file, p) : file, l = d.length;\n        var c = crc();\n        c.p(file);\n        files.push(mrg(p, {\n            size: file.length,\n            crc: c.d(),\n            c: d,\n            f: f,\n            m: m,\n            u: s != fn.length || (m && (com.length != ms)),\n            o: o,\n            compression: compression\n        }));\n        o += 30 + s + exl + l;\n        tot += 76 + 2 * (s + exl) + (ms || 0) + l;\n    }\n    var out = new u8(tot + 22), oe = o, cdl = tot - o;\n    for (var i = 0; i < files.length; ++i) {\n        var f = files[i];\n        wzh(out, f.o, f, f.f, f.u, f.c.length);\n        var badd = 30 + f.f.length + exfl(f.extra);\n        out.set(f.c, f.o + badd);\n        wzh(out, o, f, f.f, f.u, f.c.length, f.o, f.m), o += 16 + badd + (f.m ? f.m.length : 0);\n    }\n    wzf(out, o, files.length, cdl, oe);\n    return out;\n}\n/**\n * Streaming pass-through decompression for ZIP archives\n */\nvar UnzipPassThrough = /*#__PURE__*/ (function () {\n    function UnzipPassThrough() {\n    }\n    UnzipPassThrough.prototype.push = function (data, final) {\n        this.ondata(null, data, final);\n    };\n    UnzipPassThrough.compression = 0;\n    return UnzipPassThrough;\n}());\nexport { UnzipPassThrough };\n/**\n * Streaming DEFLATE decompression for ZIP archives. Prefer AsyncZipInflate for\n * better performance.\n */\nvar UnzipInflate = /*#__PURE__*/ (function () {\n    /**\n     * Creates a DEFLATE decompression that can be used in ZIP archives\n     */\n    function UnzipInflate() {\n        var _this_1 = this;\n        this.i = new Inflate(function (dat, final) {\n            _this_1.ondata(null, dat, final);\n        });\n    }\n    UnzipInflate.prototype.push = function (data, final) {\n        try {\n            this.i.push(data, final);\n        }\n        catch (e) {\n            this.ondata(e, null, final);\n        }\n    };\n    UnzipInflate.compression = 8;\n    return UnzipInflate;\n}());\nexport { UnzipInflate };\n/**\n * Asynchronous streaming DEFLATE decompression for ZIP archives\n */\nvar AsyncUnzipInflate = /*#__PURE__*/ (function () {\n    /**\n     * Creates a DEFLATE decompression that can be used in ZIP archives\n     */\n    function AsyncUnzipInflate(_, sz) {\n        var _this_1 = this;\n        if (sz < 320000) {\n            this.i = new Inflate(function (dat, final) {\n                _this_1.ondata(null, dat, final);\n            });\n        }\n        else {\n            this.i = new AsyncInflate(function (err, dat, final) {\n                _this_1.ondata(err, dat, final);\n            });\n            this.terminate = this.i.terminate;\n        }\n    }\n    AsyncUnzipInflate.prototype.push = function (data, final) {\n        if (this.i.terminate)\n            data = slc(data, 0);\n        this.i.push(data, final);\n    };\n    AsyncUnzipInflate.compression = 8;\n    return AsyncUnzipInflate;\n}());\nexport { AsyncUnzipInflate };\n/**\n * A ZIP archive decompression stream that emits files as they are discovered\n */\nvar Unzip = /*#__PURE__*/ (function () {\n    /**\n     * Creates a ZIP decompression stream\n     * @param cb The callback to call whenever a file in the ZIP archive is found\n     */\n    function Unzip(cb) {\n        this.onfile = cb;\n        this.k = [];\n        this.o = {\n            0: UnzipPassThrough\n        };\n        this.p = et;\n    }\n    /**\n     * Pushes a chunk to be unzipped\n     * @param chunk The chunk to push\n     * @param final Whether this is the last chunk\n     */\n    Unzip.prototype.push = function (chunk, final) {\n        var _this_1 = this;\n        if (!this.onfile)\n            err(5);\n        if (!this.p)\n            err(4);\n        if (this.c > 0) {\n            var len = Math.min(this.c, chunk.length);\n            var toAdd = chunk.subarray(0, len);\n            this.c -= len;\n            if (this.d)\n                this.d.push(toAdd, !this.c);\n            else\n                this.k[0].push(toAdd);\n            chunk = chunk.subarray(len);\n            if (chunk.length)\n                return this.push(chunk, final);\n        }\n        else {\n            var f = 0, i = 0, is = void 0, buf = void 0;\n            if (!this.p.length)\n                buf = chunk;\n            else if (!chunk.length)\n                buf = this.p;\n            else {\n                buf = new u8(this.p.length + chunk.length);\n                buf.set(this.p), buf.set(chunk, this.p.length);\n            }\n            var l = buf.length, oc = this.c, add = oc && this.d;\n            var _loop_2 = function () {\n                var _a;\n                var sig = b4(buf, i);\n                if (sig == 0x4034B50) {\n                    f = 1, is = i;\n                    this_1.d = null;\n                    this_1.c = 0;\n                    var bf = b2(buf, i + 6), cmp_1 = b2(buf, i + 8), u = bf & 2048, dd = bf & 8, fnl = b2(buf, i + 26), es = b2(buf, i + 28);\n                    if (l > i + 30 + fnl + es) {\n                        var chks_3 = [];\n                        this_1.k.unshift(chks_3);\n                        f = 2;\n                        var sc_1 = b4(buf, i + 18), su_1 = b4(buf, i + 22);\n                        var fn_1 = strFromU8(buf.subarray(i + 30, i += 30 + fnl), !u);\n                        if (sc_1 == 4294967295) {\n                            _a = dd ? [-2] : z64e(buf, i), sc_1 = _a[0], su_1 = _a[1];\n                        }\n                        else if (dd)\n                            sc_1 = -1;\n                        i += es;\n                        this_1.c = sc_1;\n                        var d_1;\n                        var file_1 = {\n                            name: fn_1,\n                            compression: cmp_1,\n                            start: function () {\n                                if (!file_1.ondata)\n                                    err(5);\n                                if (!sc_1)\n                                    file_1.ondata(null, et, true);\n                                else {\n                                    var ctr = _this_1.o[cmp_1];\n                                    if (!ctr)\n                                        file_1.ondata(err(14, 'unknown compression type ' + cmp_1, 1), null, false);\n                                    d_1 = sc_1 < 0 ? new ctr(fn_1) : new ctr(fn_1, sc_1, su_1);\n                                    d_1.ondata = function (err, dat, final) { file_1.ondata(err, dat, final); };\n                                    for (var _i = 0, chks_4 = chks_3; _i < chks_4.length; _i++) {\n                                        var dat = chks_4[_i];\n                                        d_1.push(dat, false);\n                                    }\n                                    if (_this_1.k[0] == chks_3 && _this_1.c)\n                                        _this_1.d = d_1;\n                                    else\n                                        d_1.push(et, true);\n                                }\n                            },\n                            terminate: function () {\n                                if (d_1 && d_1.terminate)\n                                    d_1.terminate();\n                            }\n                        };\n                        if (sc_1 >= 0)\n                            file_1.size = sc_1, file_1.originalSize = su_1;\n                        this_1.onfile(file_1);\n                    }\n                    return \"break\";\n                }\n                else if (oc) {\n                    if (sig == 0x8074B50) {\n                        is = i += 12 + (oc == -2 && 8), f = 3, this_1.c = 0;\n                        return \"break\";\n                    }\n                    else if (sig == 0x2014B50) {\n                        is = i -= 4, f = 3, this_1.c = 0;\n                        return \"break\";\n                    }\n                }\n            };\n            var this_1 = this;\n            for (; i < l - 4; ++i) {\n                var state_1 = _loop_2();\n                if (state_1 === \"break\")\n                    break;\n            }\n            this.p = et;\n            if (oc < 0) {\n                var dat = f ? buf.subarray(0, is - 12 - (oc == -2 && 8) - (b4(buf, is - 16) == 0x8074B50 && 4)) : buf.subarray(0, i);\n                if (add)\n                    add.push(dat, !!f);\n                else\n                    this.k[+(f == 2)].push(dat);\n            }\n            if (f & 2)\n                return this.push(buf.subarray(i), final);\n            this.p = buf.subarray(i);\n        }\n        if (final) {\n            if (this.c)\n                err(13);\n            this.p = null;\n        }\n    };\n    /**\n     * Registers a decoder with the stream, allowing for files compressed with\n     * the compression type provided to be expanded correctly\n     * @param decoder The decoder constructor\n     */\n    Unzip.prototype.register = function (decoder) {\n        this.o[decoder.compression] = decoder;\n    };\n    return Unzip;\n}());\nexport { Unzip };\nvar mt = typeof queueMicrotask == 'function' ? queueMicrotask : typeof setTimeout == 'function' ? setTimeout : function (fn) { fn(); };\nexport function unzip(data, opts, cb) {\n    if (!cb)\n        cb = opts, opts = {};\n    if (typeof cb != 'function')\n        err(7);\n    var term = [];\n    var tAll = function () {\n        for (var i = 0; i < term.length; ++i)\n            term[i]();\n    };\n    var files = {};\n    var cbd = function (a, b) {\n        mt(function () { cb(a, b); });\n    };\n    mt(function () { cbd = cb; });\n    var e = data.length - 22;\n    for (; b4(data, e) != 0x6054B50; --e) {\n        if (!e || data.length - e > 65558) {\n            cbd(err(13, 0, 1), null);\n            return tAll;\n        }\n    }\n    ;\n    var lft = b2(data, e + 8);\n    if (lft) {\n        var c = lft;\n        var o = b4(data, e + 16);\n        var z = o == 4294967295;\n        if (z) {\n            e = b4(data, e - 12);\n            if (b4(data, e) != 0x6064B50) {\n                cbd(err(13, 0, 1), null);\n                return tAll;\n            }\n            c = lft = b4(data, e + 32);\n            o = b4(data, e + 48);\n        }\n        var fltr = opts && opts.filter;\n        var _loop_3 = function (i) {\n            var _a = zh(data, o, z), c_1 = _a[0], sc = _a[1], su = _a[2], fn = _a[3], no = _a[4], off = _a[5], b = slzh(data, off);\n            o = no;\n            var cbl = function (e, d) {\n                if (e) {\n                    tAll();\n                    cbd(e, null);\n                }\n                else {\n                    if (d)\n                        files[fn] = d;\n                    if (!--lft)\n                        cbd(null, files);\n                }\n            };\n            if (!fltr || fltr({\n                name: fn,\n                size: sc,\n                originalSize: su,\n                compression: c_1\n            })) {\n                if (!c_1)\n                    cbl(null, slc(data, b, b + sc));\n                else if (c_1 == 8) {\n                    var infl = data.subarray(b, b + sc);\n                    if (sc < 320000) {\n                        try {\n                            cbl(null, inflateSync(infl, new u8(su)));\n                        }\n                        catch (e) {\n                            cbl(e, null);\n                        }\n                    }\n                    else\n                        term.push(inflate(infl, { size: su }, cbl));\n                }\n                else\n                    cbl(err(14, 'unknown compression type ' + c_1, 1), null);\n            }\n            else\n                cbl(null, null);\n        };\n        for (var i = 0; i < c; ++i) {\n            _loop_3(i);\n        }\n    }\n    else\n        cbd(null, {});\n    return tAll;\n}\n/**\n * Synchronously decompresses a ZIP archive. Prefer using `unzip` for better\n * performance with more than one file.\n * @param data The raw compressed ZIP file\n * @param opts The ZIP extraction options\n * @returns The decompressed files\n */\nexport function unzipSync(data, opts) {\n    var files = {};\n    var e = data.length - 22;\n    for (; b4(data, e) != 0x6054B50; --e) {\n        if (!e || data.length - e > 65558)\n            err(13);\n    }\n    ;\n    var c = b2(data, e + 8);\n    if (!c)\n        return {};\n    var o = b4(data, e + 16);\n    var z = o == 4294967295;\n    if (z) {\n        e = b4(data, e - 12);\n        if (b4(data, e) != 0x6064B50)\n            err(13);\n        c = b4(data, e + 32);\n        o = b4(data, e + 48);\n    }\n    var fltr = opts && opts.filter;\n    for (var i = 0; i < c; ++i) {\n        var _a = zh(data, o, z), c_2 = _a[0], sc = _a[1], su = _a[2], fn = _a[3], no = _a[4], off = _a[5], b = slzh(data, off);\n        o = no;\n        if (!fltr || fltr({\n            name: fn,\n            size: sc,\n            originalSize: su,\n            compression: c_2\n        })) {\n            if (!c_2)\n                files[fn] = slc(data, b, b + sc);\n            else if (c_2 == 8)\n                files[fn] = inflateSync(data.subarray(b, b + sc), new u8(su));\n            else\n                err(14, 'unknown compression type ' + c_2);\n        }\n    }\n    return files;\n}\n","/** @fileoverview Functions used by multiple content-specific cache modules */\n\nimport {decompressSync, strFromU8} from 'fflate';\n\nimport version from '../../version';\nimport {getEarlyTaxid, slug, getDir} from '../../lib';\nimport {organismMetadata} from '../organism-metadata';\n\n/** Reports if current organism has a gene structure cache */\nexport function supportsCache(orgName, cacheName) {\n  const metadata = parseOrgMetadata(orgName);\n  const cacheProp = 'has' + cacheName + 'Cache';\n  return metadata[cacheProp] && metadata[cacheProp] === true;\n}\n\n/** Get URL for gene structure cache file */\nexport function getCacheUrl(orgName, cacheDir, cacheType, fileType='tsv') {\n  const organism = slug(orgName);\n  if (!cacheDir) {\n    cacheDir = getDir('cache/' + cacheType + '/');\n  } else {\n    cacheDir += cacheType + '/';\n  }\n\n  const cacheUrl =\n    cacheDir + organism + '-' + cacheType + '.' + fileType + '.gz';\n\n  return cacheUrl;\n}\n\n/**\n * Build full Ensembl ID from prefix (e.g. ENSG) and slim ID (e.g. 223972)\n *\n * Example output ID: ENSG00000223972\n * */\nexport function getEnsemblId(ensemblPrefix, slimEnsemblId) {\n\n  // C. elegans (prefix: WBGene) has special IDs, e.g. WBGene00197333\n  const padLength = ensemblPrefix === 'WBGene' ? 8 : 11;\n\n  // Zero-pad the slim ID, e.g. 223972 -> 00000223972\n  const zeroPaddedId = slimEnsemblId.padStart(padLength, '0');\n\n  return ensemblPrefix + zeroPaddedId;\n}\n\nexport async function cacheFetch(url) {\n\n  const cache = await caches.open(`ideogram-${version}`);\n\n  const decompressedUrl = url.replace('.gz', '');\n  const response = await cache.match(decompressedUrl);\n  if (typeof response === 'undefined') {\n    // If cache miss, then fetch and add response to cache\n    const rawResponse = await fetch(url);\n    const blob = await rawResponse.blob();\n    const uint8Array = new Uint8Array(await blob.arrayBuffer());\n    const data = strFromU8(decompressSync(uint8Array));\n    const decompressedResponse = new Response(\n      new Blob([data], {type: 'text/tab-separated-values'}),\n      rawResponse.init\n    );\n    await cache.put(decompressedUrl, decompressedResponse);\n    return await cache.match(decompressedUrl);\n  }\n  return await cache.match(decompressedUrl);\n}\n\n/** Get organism's metadata fields */\nexport function parseOrgMetadata(orgName) {\n  const taxid = getEarlyTaxid(orgName);\n  return organismMetadata[taxid] || {};\n}\n\n/** Fetch URL from service worker cache, call given parsing function */\nexport async function fetchAndParse(\n  cacheUrl, perfTimes, parseFn, orgName=null\n) {\n  const fetchStartTime = performance.now();\n  const response = await cacheFetch(cacheUrl);\n  let data;\n  if (cacheUrl.includes('.json')) {\n    data = await response.json();\n  } else {\n    data = await response.text();\n  }\n  const fetchEndTime = performance.now();\n  perfTimes.fetch = Math.round(fetchEndTime - fetchStartTime);\n\n  const parsedCache = parseFn(data, perfTimes, orgName);\n  perfTimes.parseCache = Math.round(performance.now() - fetchEndTime);\n\n  return [parsedCache, perfTimes];\n}\n\n/** Print size and time of given parsed cache */\nexport function inspectWorker(cacheName, json) {\n  const size = new TextEncoder().encode(JSON.stringify(json)).length;\n  const kiloBytes = size / 1024;\n  const megaBytes = kiloBytes / 1024;\n  console.log(`Parsed ${cacheName}Cache size: ${megaBytes} MiB`);\n  console.timeEnd(`${cacheName}CacheWorker`);\n}\n","import {fetchAndParse, inspectWorker} from './cache-lib';\n\n/** Parse compressed feature subparts to more easily computable format */\nfunction deserializeSubparts(rawSubparts, subpartKeys) {\n  const subparts = [];\n  for (let i = 0; i < rawSubparts.length; i++) {\n    const rawSubpart = rawSubparts[i].split(';');\n    const subpartType = subpartKeys[parseInt(rawSubpart[0])];\n    const start = parseInt(rawSubpart[1]);\n    const length = parseInt(rawSubpart[2]);\n    const subpart = [subpartType, start, length];\n    subparts.push(subpart);\n  }\n  return subparts;\n}\n\n/** Parse metainformation header lines, i.e. those beginning  \"## \"\" */\nfunction parseMetainformationHeader(line) {\n  const splitHead = line.split(' keys: ');\n  if (splitHead.length < 2) return [null];\n  const metaHeader = splitHead[0].split('## ')[1];\n  const keys = {};\n  splitHead[1].split(', ').forEach(entry => {\n    const splitEntry = entry.split(' = ');\n    keys[splitEntry[0]] = splitEntry[1];\n  });\n  return [metaHeader, keys];\n}\n\n/** Parse a gene structure cache TSV file, return array of useful transforms */\nexport function parseCache(rawTsv, perfTimes) {\n  const featuresByGene = {};\n\n  let t0 = performance.now();\n  const lines = rawTsv.split(/\\r\\n|\\n/);\n  perfTimes.rawTsvSplit = Math.round(performance.now() - t0);\n\n  let biotypeKeys, subpartKeys;\n\n  t0 = performance.now();\n  for (let i = 0; i < lines.length; i++) {\n    const line = lines[i];\n    if (line === '') continue; // Skip empty lines\n\n    // Parse header\n    if (line[0] === '#') {\n\n      // Parse metainformation headers\n      if (line[1] === '#') {\n        const [metaHeader, keys] = parseMetainformationHeader(line);\n        if (metaHeader === 'biotype') {\n          biotypeKeys = keys;\n        } else if (metaHeader === 'subpart') {\n          subpartKeys = keys;\n        }\n      }\n      continue;\n    }\n    const splitLine = line.trim().split(/\\t/);\n\n    const [\n      name, biotypeCompressed, strand\n    ] = splitLine.slice(0, 3);\n\n    const gene = name.split('-').slice(0, -1).join('-');\n\n    const rawSubparts = splitLine.slice(3);\n    const subparts = deserializeSubparts(rawSubparts, subpartKeys);\n\n    const biotype = biotypeKeys[biotypeCompressed];\n\n    // E.g. ACE2-201, protein_coding, -, <array of exon or UTR arrays>\n    const feature = {\n      name,\n      biotype,\n      strand,\n      subparts\n    };\n\n    if (gene in featuresByGene) {\n      featuresByGene[gene].push(feature);\n    } else {\n      featuresByGene[gene] = [feature];\n    }\n\n  };\n  const t1 = performance.now();\n  perfTimes.parseCacheLoop = Math.round(t1 - t0);\n\n  return featuresByGene;\n}\n\n// Uncomment when workers work outside localhost\n// addEventListener('message', async event => {\n//   console.time('geneStructureCacheWorker');\n//   const [cacheUrl, perfTimes, debug] = event.data;\n//   const result = await fetchAndParse(cacheUrl, perfTimes, parseCache);\n//   postMessage(result);\n//   if (debug) inspectWorker('geneStructure', result[0]);\n// });\n","import {supportsCache, getCacheUrl, fetchAndParse} from './cache-lib';\n\n// Uncomment when workers work outside localhost\n// const geneCacheWorker = new Worker(\n//   new URL('./gene-cache-worker.js', import.meta.url), {type: 'module'}\n// );\n// const paralogCacheWorker = new Worker(\n//   new URL('./paralog-cache-worker.js', import.meta.url), {type: 'module'}\n// );\n// const interactionCacheWorker = new Worker(\n//   new URL('./interaction-cache-worker.js', import.meta.url), {type: 'module'}\n// );\n// const geneStructureCacheWorker = new Worker(\n//   new URL('./gene-structure-cache-worker.js', import.meta.url), {type: 'module'}\n// );\n\nimport {parseCache as parseGeneCache} from './gene-cache-worker';\nimport {parseCache as parseParalogCache} from './paralog-cache-worker';\nimport {parseCache as parseInteractionCache} from './interaction-cache-worker';\nimport {\n  parseCache as parseGeneStructureCache\n} from './gene-structure-cache-worker';\n\n\n/**\n * Populates in-memory content caches from on-disk service worker (SW) caches.\n *\n * This warms the following content caches:\n * - Gene cache: gene symbol -> full name, Ensembl ID, genomic coordinates\n * - Paralog cache: gene symbol -> paralogs (evolutionarily related genes)\n * - Interaction cache: gene symbol -> adjacent genes in biochemical pathways\n *\n * And, optionally:\n * - Gene structure cache: gene symbol -> canonical transcript, exons, UTRs\n *\n * Used for related genes kit now, likely worth generalizing in the future.\n *\n * This approach makes navigating related genes ideogram instant and\n * possible completely offline (i.e. a progressive web component) -- but only\n * once caches are populated.\n */\nexport async function initCaches(ideo) {\n\n  const config = ideo.config;\n  if (!config.useCache) return;\n\n  const organism = config.organism;\n\n  let cacheDir = null;\n  if (config.cacheDir) cacheDir = config.cacheDir;\n\n  if (config.awaitCache) {\n    // Start all these in parallel.  Only initGeneCache blocks; it internally\n    // resolves a Promise, whereas the others return upon completing their\n    // respective initializations.\n    const cachePromise = Promise.all([\n      cacheFactory('gene', organism, ideo, cacheDir),\n      cacheFactory('paralog', organism, ideo, cacheDir),\n      cacheFactory('interaction', organism, ideo, cacheDir)\n    ]);\n\n    if (config.showGeneStructureInTooltip) {\n      cacheFactory('geneStructure', organism, ideo, cacheDir);\n    }\n\n    return cachePromise;\n\n  } else {\n    cacheFactory('gene', organism, ideo, cacheDir);\n    cacheFactory('paralog', organism, ideo, cacheDir);\n    cacheFactory('interaction', organism, ideo, cacheDir);\n    if (config.showGeneStructureInTooltip) {\n      cacheFactory('geneStructure', organism, ideo, cacheDir);\n    }\n  }\n}\n\nconst allCacheProps = {\n  gene: {\n    metadata: 'Gene', dir: 'genes',\n    fn: setGeneCache,\n    // worker: geneCacheWorker // Uncomment when workers work\n    parseFn: parseGeneCache // Remove when workers work\n  },\n  paralog: {\n    metadata: 'Paralog', dir: 'paralogs',\n    fn: setParalogCache,\n    // worker: paralogCacheWorker // Uncomment when workers work\n    parseFn: parseParalogCache // Remove when workers work\n  },\n  interaction: {\n    metadata: 'Interaction', dir: 'interactions',\n    fn: setInteractionCache, extension: 'json',\n    // worker: interactionCacheWorker, // Uncomment when workers work\n    parseFn: parseInteractionCache // Remove when workers work\n  },\n  geneStructure: {\n    metadata: 'GeneStructure', dir: 'gene-structures-all',\n    fn: setGeneStructureCache,\n    // worker: geneStructureCacheWorker // Uncomment when workers work\n    parseFn: parseGeneStructureCache // Remove when workers work\n  }\n};\n\nfunction setGeneCache(parsedCache, ideo) {\n  const [\n    interestingNames, nameCaseMap, namesById, fullNamesById,\n    idsByName, lociByName, lociById\n    //, sortedAnnots\n  ] = parsedCache;\n\n  ideo.geneCache = {\n    interestingNames, // Array ordered by general or scholarly interest\n    nameCaseMap, // Maps of lowercase gene names to proper gene names\n    namesById,\n    fullNamesById,\n    idsByName,\n    lociByName, // Object of gene positions, keyed by gene name\n    lociById\n    //, sortedAnnots // Ideogram annotations sorted by genomic position\n  };\n}\n\nfunction setParalogCache(parsedCache, ideo) {\n  const paralogsByName = parsedCache;\n  // Array of paralog Ensembl IDs by (uppercase) gene name\n  ideo.paralogCache = {paralogsByName};\n}\n\nfunction setInteractionCache(parsedCache, ideo) {\n  const interactionsByName = parsedCache;\n  ideo.interactionCache = interactionsByName;\n}\n\nfunction setGeneStructureCache(parsedCache, ideo) {\n  const featuresByGene = parsedCache;\n  ideo.geneStructureCache = featuresByGene;\n}\n\nasync function cacheFactory(cacheName, orgName, ideo, cacheDir=null) {\n\n  const cacheProps = allCacheProps[cacheName];\n  const debug = ideo.config.debug;\n\n  /**\n * Fetch cached gene data, transform it usefully, and set it as ideo prop\n */\n  const startTime = performance.now();\n  let perfTimes = {};\n\n  let parsedCache;\n\n  // Skip initialization if files needed to make cache don't exist\n  if (!supportsCache(orgName, cacheProps.metadata)) return;\n\n  const staticProp = cacheName + 'Cache';\n  // Skip initialization if cache is already populated\n  if (Ideogram[staticProp] && Ideogram[staticProp][orgName]) {\n    // Simplify chief use case, i.e. for single organism\n    ideo[staticProp] = Ideogram[staticProp][orgName];\n    return;\n  }\n\n  if (!Ideogram[staticProp]) {\n    Ideogram[staticProp] = {};\n  }\n\n  const extension = cacheProps?.extension ?? 'tsv';\n  const cacheUrl = getCacheUrl(orgName, cacheDir, cacheProps.dir, extension);\n\n  [parsedCache, perfTimes] =\n    await fetchAndParse(cacheUrl, perfTimes, cacheProps.parseFn, orgName);\n\n  // const cacheWorker = cacheProps.worker;\n  if (debug) console.time(`${cacheName}Cache total`);\n  return new Promise(resolve => {\n  //   const message = [cacheUrl, perfTimes, debug];\n  //   if (cacheName === 'interaction') message.push(orgName);\n  //   cacheWorker.postMessage(message);\n  //   cacheWorker.addEventListener('message', event => {\n  //     [parsedCache, perfTimes] = event.data;\n      cacheProps.fn(parsedCache, ideo, orgName);\n      Ideogram[staticProp][orgName] = ideo[staticProp];\n\n      if (debug) {\n        console.timeEnd(`${cacheName}Cache total`);\n        perfTimes.total = Math.round(performance.now() - startTime);\n        const preamble = 'perfTimes in init' + cacheProps.metadata + 'Cache:';\n        console.log(preamble, perfTimes);\n      }\n\n      resolve();\n    // });\n  });\n}\n","import {fetchAndParse, getEnsemblId, inspectWorker} from './cache-lib';\n\n/**\n * Convert pre-annotation arrays to annotation objects\n * sorted by genomic position.\n */\nfunction parseAnnots(preAnnots) {\n  const chromosomes = {};\n\n  for (let i = 0; i < preAnnots.length; i++) {\n    const [chromosome, start, stop, ensemblId, gene] = preAnnots[i];\n\n    if (!(chromosome in chromosomes)) {\n      chromosomes[chromosome] = {chr: chromosome, annots: []};\n    } else {\n      const annot = {name: gene, start, stop, ensemblId};\n      chromosomes[chromosome].annots.push(annot);\n    }\n  }\n\n  const annotsSortedByPosition = {};\n\n  Object.entries(chromosomes).forEach(([chr, annotsByChr]) => {\n    annotsSortedByPosition[chr] = {\n      chr,\n      annots: annotsByChr.annots.sort((a, b) => a.start - b.start)\n    };\n  });\n\n  return annotsSortedByPosition;\n}\n\n/** Parse a gene cache TSV file, return array of useful transforms */\nexport function parseCache(rawTsv, perfTimes) {\n  const names = [];\n  const nameCaseMap = {};\n  const namesById = {};\n  const fullNamesById = {};\n  const idsByName = {};\n  const lociByName = {};\n  const lociById = {};\n  const preAnnots = [];\n  let ensemblPrefix;\n\n  let t0 = performance.now();\n  const lines = rawTsv.split(/\\r\\n|\\n/);\n  perfTimes.rawTsvSplit = Math.round(performance.now() - t0);\n\n  t0 = performance.now();\n  for (let i = 0; i < lines.length; i++) {\n    const line = lines[i];\n    if (line === '') continue; // Skip empty lines\n    if (line[0] === '#') {\n      if (line.slice(0, 9) === '## prefix') {\n        ensemblPrefix = line.split('prefix: ')[1];\n      }\n      continue;\n    }\n    const [\n      chromosome, rawStart, rawLength, slimEnsemblId, gene\n      , rawFullName\n    ] = line.trim().split(/\\t/);\n    const fullName = decodeURIComponent(rawFullName);\n    const start = parseInt(rawStart);\n    const stop = start + parseInt(rawLength);\n    const ensemblId = getEnsemblId(ensemblPrefix, slimEnsemblId);\n    preAnnots.push([chromosome, start, stop, ensemblId, gene, fullName]);\n    const locus = [chromosome, start, stop];\n\n    names.push(gene);\n    nameCaseMap[gene.toLowerCase()] = gene;\n    namesById[ensemblId] = gene;\n    fullNamesById[ensemblId] = fullName;\n    idsByName[gene] = ensemblId;\n    lociByName[gene] = locus;\n    lociById[ensemblId] = locus;\n  };\n  const t1 = performance.now();\n  perfTimes.parseCacheLoop = Math.round(t1 - t0);\n\n  // const sortedAnnots = parseAnnots(preAnnots);\n  perfTimes.parseAnnots = Math.round(performance.now() - t1);\n\n  return [\n    names, nameCaseMap, namesById,\n    fullNamesById,\n    idsByName, lociByName, lociById\n    // , sortedAnnots\n  ];\n}\n\n// Uncomment when workers work outside localhost\n// addEventListener('message', async event => {\n//   console.time('geneCacheWorker');\n//   // console.log('in gene cache worker message handler');\n//   const [cacheUrl, perfTimes, debug] = event.data;\n//   const result = await fetchAndParse(cacheUrl, perfTimes, parseCache);\n//   postMessage(result);\n//   if (debug) inspectWorker('gene', result[0]);\n// });\n","import {fetchAndParse, getEnsemblId, inspectWorker} from './cache-lib';\n\n/** Parse a paralog cache TSV file, return array of useful transforms */\nexport function parseCache(rawTsv, perfTimes) {\n  const paralogsByName = {};\n  let ensemblPrefix;\n\n  let t0 = performance.now();\n  const lines = rawTsv.split(/\\r\\n|\\n/);\n  perfTimes.rawTsvSplit = Math.round(performance.now() - t0);\n\n  t0 = performance.now();\n  for (let i = 0; i < lines.length; i++) {\n    const line = lines[i];\n    if (line === '') continue; // Skip empty lines\n    if (line[0] === '#') {\n      if (line.slice(0, 9) === '## prefix') {\n        ensemblPrefix = line.split('prefix: ')[1];\n      }\n      continue;\n    }\n    const columns = line.trim().split(/\\t/);\n    const gene = columns[0];\n    const geneSlimId = columns[1];\n\n    const paralogs = [];\n    if (columns[2][0] === '_') {\n      const pointer = columns[2].slice(1).toUpperCase();\n      const paralogSuperList = paralogsByName[pointer];\n      const geneId = getEnsemblId(ensemblPrefix, geneSlimId);\n      for (let j = 0; j < paralogSuperList.length; j++) {\n        const id = paralogSuperList[j];\n        if (id !== geneId) {\n          paralogs.push(id);\n        }\n      }\n      paralogs.unshift(getEnsemblId(ensemblPrefix, columns[3]));\n    } else {\n      const slimEnsemblIds = columns.slice(2);\n      for (let j = 0; j < slimEnsemblIds.length; j++) {\n        const slimId = slimEnsemblIds[j];\n        if (slimId !== geneSlimId) {\n          paralogs.push(getEnsemblId(ensemblPrefix, slimId));\n        }\n      }\n    }\n\n    paralogsByName[gene.toUpperCase()] = paralogs;\n  };\n  const t1 = performance.now();\n  perfTimes.parseCacheLoop = Math.round(t1 - t0);\n\n  return paralogsByName;\n}\n\n// Uncomment when workers work outside localhost\n// addEventListener('message', async event => {\n//   console.time('paralogCacheWorker');\n//   const [cacheUrl, perfTimes, debug] = event.data;\n//   const result = await fetchAndParse(cacheUrl, perfTimes, parseCache);\n//   postMessage(result);\n//   if (debug) inspectWorker('paralog', result[0]);\n// });\n","import {fetchAndParse, inspectWorker} from './cache-lib';\n\n/** Parse an interaction cache JSON file, return array of useful transforms */\nexport function parseCache(rawJson, perfTimes, orgName) {\n  let t0 = performance.now();\n  const interactionsByName = {};\n  const tmp = orgName.replace('-', ' ');\n  const desluggedOrg = tmp[0].toUpperCase() + tmp.slice(1);\n\n  t0 = performance.now();\n  for (const gene in rawJson['interactions']) {\n    const ixnLists = rawJson['interactions'][gene];\n    interactionsByName[gene] = {result: []};\n    for (let i = 0; i < ixnLists.length; i++) {\n      const compressedIxn = ixnLists[i];\n      const slimPwId = compressedIxn[0];\n      interactionsByName[gene].result.push({\n        fields: {\n          left: {values: compressedIxn[1]},\n          right: {values: compressedIxn[2]}\n        },\n        id: 'WP' + slimPwId,\n        name: rawJson['pathwayNamesById'][slimPwId],\n        species: desluggedOrg\n      });\n    }\n  }\n  const t1 = performance.now();\n  perfTimes.parseCacheLoop = Math.round(t1 - t0);\n\n  return interactionsByName;\n}\n\n// Uncomment when workers work outside localhost\n// addEventListener('message', async event => {\n//   console.time('interactionCacheWorker');\n//   const [cacheUrl, perfTimes, debug, orgName] = event.data;\n//   const result = await fetchAndParse(cacheUrl, perfTimes, parseCache, orgName);\n//   postMessage(result);\n//   if (debug) inspectWorker('interaction', result[0]);\n// });\n","import {d3} from '../lib';\nimport collinearizeChromosomes from '../collinear';\nimport {initCaches} from './caches/cache';\n\nfunction processLabels(config, ideo) {\n  var i, chrID, t0C, t1C;\n\n  if (config.showBandLabels === true) {\n    t0C = new Date().getTime();\n    ideo.hideUnshownBandLabels();\n    t1C = new Date().getTime();\n    if (config.debug) {\n      console.log('Time in showing bands: ' + (t1C - t0C) + ' ms');\n    }\n\n    if (config.orientation === 'vertical') {\n      for (i = 0; i < ideo.chromosomesArray.length; i++) {\n        chrID = '#' + ideo.chromosomesArray[i].id;\n        ideo.rotateChromosomeLabels(d3.select(chrID), i);\n      }\n    }\n  }\n\n  if (config.showChromosomeLabels === true) {\n    ideo.drawChromosomeLabels(ideo.chromosomes);\n  }\n}\n\nfunction processAnnots(ideo) {\n  if (typeof ideo.timeout !== 'undefined') window.clearTimeout(ideo.timeout);\n\n  ideo.rawAnnots = ideo.setOriginalTrackIndexes(ideo.rawAnnots);\n\n  if (ideo.config.annotationsDisplayedTracks) {\n    ideo.annots =\n      ideo.updateDisplayedTracks(ideo.config.annotationsDisplayedTracks);\n  } else {\n    ideo.annots = ideo.processAnnotData(ideo.rawAnnots);\n    if (ideo.config.filterable) ideo.initCrossFilter();\n    ideo.drawProcessedAnnots(ideo.annots);\n  }\n}\n\n/**\n * Load (potentially large) annotation dataset, then process it.\n */\nfunction waitForAndProcessAnnots(ideo) {\n  if (ideo.rawAnnots) {\n    processAnnots(ideo);\n  } else {\n    (function checkAnnotData() {\n      ideo.timeout = setTimeout(function() {\n        if (\n          !ideo.rawAnnots ||\n          (ideo.rawAnnots && typeof ideo.rawAnnots.then !== 'undefined')\n        ) {\n          // Ensure rawAnnots is defined and not a Promise (not \"then\"-able)\n          checkAnnotData();\n        } else {\n          processAnnots(ideo);\n        }\n      }, 50);\n    })();\n  }\n}\n\nfunction reportDebugTimings(config, t0, t0A) {\n\n  var t1A = new Date().getTime();\n  if (config.debug) {\n    console.log('Time in drawChromosome: ' + (t1A - t0A) + ' ms');\n  }\n\n  var t1 = new Date().getTime();\n  if (config.debug) {\n    console.log('Time constructing ideogram: ' + (t1 - t0) + ' ms');\n  }\n}\n\n/**\n * Completes high-level initialization.\n * Draws chromosomes and band labels, rotating as needed;\n * processes and draws annotations;\n * creates brush, emits notification of load completion, etc.\n */\nfunction finishInit(t0) {\n  var t0A = new Date().getTime(),\n    ideo = this,\n    config = ideo.config,\n    confAnnots = config.annotations;\n\n  ideo.initDrawChromosomes();\n\n  if (config.annotationsPath) waitForAndProcessAnnots(ideo);\n\n  processLabels(config, ideo);\n\n  // Create a brush or a click cursor if specified\n  if (config.brush) ideo.createBrush(config.brush);\n  else if (config.cursorPosition) ideo.createClickCursor(config.cursorPosition);\n\n  if (confAnnots) {\n    if (Array.isArray(confAnnots)) {\n      ideo.drawAnnots(confAnnots);\n    } else {\n      // Enable client-side-defined annotations to be formatted\n      // like the wider variety of server-side-defined annotations.\n      // Supports https://github.com/eweitz/ideogram/issues/137\n      ideo.rawAnnots = confAnnots;\n      ideo.afterRawAnnots();\n      processAnnots(ideo);\n    }\n  }\n\n  reportDebugTimings(config, t0, t0A);\n\n  ideo.setOverflowScroll();\n\n  if (config.geometry === 'collinear') collinearizeChromosomes(ideo);\n\n  if (ideo.config.debug) console.time('initCache: Ideogram');\n  initCaches(ideo).then(() => {\n    if (ideo.config.debug) console.timeEnd('initCache: Ideogram');\n    if (ideo.onLoadCallback) ideo.onLoadCallback();\n  });\n}\n\nexport {finishInit};\n","export class Ploidy {\n\n  constructor(config) {\n    this._config = config;\n    this._description = this._normalize(this._config.ploidyDesc);\n  }\n\n  // Get number of chromosomes in a chromosome set\n  getChromosomesNumber(setIndex) {\n    if (this._config.ploidyDesc) {\n      var chrSetCode = this._config.ploidyDesc[setIndex];\n      if (chrSetCode instanceof Object) {\n        return Object.keys(chrSetCode)[0].length;\n      } else {\n        return chrSetCode.length;\n      }\n    } else {\n      return this._config.ploidy || 1;\n    }\n  }\n\n  // Normalize use defined description\n  _normalize(description) {\n    var key, descValue,\n      normalized = [];\n\n    if (!description) return description;\n\n    // Loop through description and normalize\n    for (key in description) {\n      descValue = description[key];\n      if (typeof descValue === 'string') {\n        if (this._config.orientation === 'vertical') {\n          descValue = descValue.split('').reverse();\n        }\n        normalized.push({\n          ancestors: descValue,\n          existence: this._getexistenceArray(descValue.length)\n        });\n      } else {\n        normalized.push({\n          ancestors: Object.keys(descValue)[0],\n          existence: descValue[Object.keys(descValue)[0]]\n        });\n      }\n    }\n\n    return normalized;\n  }\n\n  // Get array filled by '11' elements\n  _getexistenceArray(length) {\n    var array = [];\n\n    for (var i = 0; i < length; i++) {\n      array.push('11');\n    }\n\n    return array;\n  }\n\n  getSetSize(chrSetIndex) {\n    if (this._description) {\n      return this._description[chrSetIndex].ancestors.length;\n    } else {\n      return 1;\n    }\n  }\n\n  // Get ancestor letter\n  getAncestor(chrSetIndex, chrIndex) {\n    if (this._description) {\n      return this._description[chrSetIndex].ancestors[chrIndex];\n    } else {\n      return '';\n    }\n  }\n\n  // Check if chromosome's arm should be rendered.\n  // If no description was provided, method returns true and\n  // something another depending on user provided description.\n  exists(chrSetIndex, chrIndex, armIndex) {\n    if (this._description) {\n      var desc =\n        this._description[chrSetIndex].existence[chrIndex][armIndex];\n      return Number(desc) > 0;\n    } else {\n      return true;\n    }\n  }\n\n}\n","import {d3} from '../lib';\n\n/**\n * Chromosome's view utility class\n */\nexport class ChromosomeUtil {\n\n  constructor(node) {\n    this._node = node;\n  }\n\n  getLabel() {\n    var label =\n      d3\n        .select(this._node.parentNode)\n        .select('text.chrLabel')\n        .text();\n    return label;\n  }\n\n  /**\n   * Get chromosome set label\n   */\n  getSetLabel() {\n    var setLabel =\n      d3\n        .select(this._node.parentNode)\n        .select('text.chrSetLabel')\n        .text();\n    return setLabel;\n  }\n}\n","import {d3} from '../lib';\nimport {ChromosomeUtil} from './../views/chromosome-util';\n\nclass Layout {\n\n  constructor(config, ideo) {\n    this._config = config;\n    this._ideo = ideo;\n    this._ploidy = this._ideo._ploidy;\n    this._translate = undefined;\n\n    if ('chrSetMargin' in config) {\n      this.chrSetMargin = config.chrSetMargin;\n    } else {\n      var chrMargin = this._config.chrMargin;\n      this.chrSetMargin = (this._config.ploidy > 1 ? chrMargin : 0);\n    }\n\n    // Chromosome band's size.\n    this._tickSize = 8;\n\n    // Chromosome rotation state.\n    this._isRotated = false;\n  }\n\n  // Get chart left margin\n  _getLeftMargin() {\n    return this.margin.left;\n  }\n\n  // Get rotated chromosome y scale\n  _getYScale() {\n    // 20 is width of rotated chromosome.\n    return 20 / this._config.chrWidth;\n  }\n\n  // Get chromosome labels\n  getChromosomeLabels(chrElement) {\n    var util = new ChromosomeUtil(chrElement),\n      labels = [];\n\n    if (this._ideo.config.ploidy > 1) {\n      labels.push(util.getSetLabel());\n    }\n    labels.push(util.getLabel());\n\n    return labels.filter(function(d) {\n      return d.length > 0;\n    });\n  }\n\n  getChromosomeBandLabelTranslate(band) {\n    var x, y, translate,\n      ideo = this._ideo,\n      tickSize = this._tickSize,\n      orientation = ideo.config.orientation;\n\n    if (orientation === 'vertical') {\n      x = tickSize;\n      y = ideo.round(2 + band.px.start + band.px.width / 2);\n      translate = 'rotate(-90)translate(' + x + ',' + y + ')';\n    } else if (orientation === 'horizontal') {\n      x = ideo.round(-tickSize + band.px.start + band.px.width / 2);\n      y = -10;\n      translate = 'translate(' + x + ',' + y + ')';\n    }\n\n    return {\n      x: x,\n      y: y,\n      translate: translate\n    };\n  }\n\n  didRotate(chrIndex, chrElement) {\n    var ideo, taxid, chrName, bands, chrModel, oldWidth,\n      chrSetElement, transform, scale, scaleRE;\n\n    ideo = this._ideo;\n    taxid = ideo.config.taxid;\n    chrName = chrElement.id.split('-')[0].replace('chr', '');\n    chrModel = ideo.chromosomes[taxid][chrName];\n    bands = chrModel.bands;\n\n    chrSetElement = d3.select(chrElement.parentNode);\n    transform = chrSetElement.attr('transform');\n    scaleRE = /scale\\(.*\\)/;\n    scale = scaleRE.exec(transform);\n    transform = transform.replace(scale, '');\n    chrSetElement.attr('transform', transform);\n\n    oldWidth = chrModel.width;\n\n    chrModel = ideo.getChromosomeModel(bands, chrName, taxid, chrIndex);\n\n    chrModel.oldWidth = oldWidth;\n\n    ideo.chromosomes[taxid][chrName] = chrModel;\n    ideo.drawChromosome(chrModel);\n\n    ideo.handleRotateOnClick();\n\n    if (ideo.rawAnnots) {\n      if (ideo.displayedTrackIndexes) {\n        ideo.updateDisplayedTracks(ideo.displayedTrackIndexes);\n      } else {\n        ideo.annots = ideo.processAnnotData(ideo.rawAnnots);\n        ideo.drawProcessedAnnots(ideo.annots);\n\n        if (ideo.config.filterable) {\n          ideo.initCrossFilter();\n        }\n      }\n    }\n\n    if (ideo.config.showBandLabels === true) {\n      ideo.drawBandLabels(ideo.chromosomes);\n      ideo.hideUnshownBandLabels();\n    }\n\n    if (ideo.onDidRotateCallback) {\n      ideo.onDidRotateCallback(chrModel);\n    }\n  }\n\n  rotate(chrSetIndex, chrIndex, chrElement) {\n    var ideo, otherChrs, ideoBounds, labelSelectors;\n    ideo = this._ideo;\n\n    labelSelectors = (\n      ideo.selector + ' .chrSetLabel, ' + ideo.selector + ' .chrLabel'\n    );\n\n    ideoBounds = document.querySelector(ideo.selector).getBoundingClientRect();\n\n    // Find chromosomes which should be hidden\n    otherChrs = d3.selectAll(ideo.selector + ' g.chromosome')\n      .filter(function() {return this !== chrElement;});\n\n    if (this._isRotated) {\n\n      this._isRotated = false;\n\n      ideo.config.chrHeight = ideo.config.chrHeightOriginal;\n      ideo.config.chrWidth = ideo.config.chrWidthOriginal;\n      ideo.config.annotationHeight = ideo.config.annotationHeightOriginal;\n\n      // Rotate chromosome back\n      this.rotateBack(chrSetIndex, chrIndex, chrElement, function() {\n        // Show all other chromosomes and chromosome labels\n        otherChrs.style('display', null);\n        d3.selectAll(labelSelectors).style('display', null);\n        ideo._layout.didRotate(chrIndex, chrElement);\n      });\n\n    } else {\n\n      this._isRotated = true;\n\n      // Hide all other chromosomes and chromosome labels\n      otherChrs.style('display', 'none');\n      d3.selectAll(labelSelectors).style('display', 'none');\n\n      // Rotate chromosome\n      this.rotateForward(chrSetIndex, chrIndex, chrElement, function() {\n\n        var chrHeight, elementLength, windowLength;\n\n        ideo.config.chrHeightOriginal = ideo.config.chrHeight;\n        ideo.config.chrWidthOriginal = ideo.config.chrWidth;\n        ideo.config.annotationHeightOriginal = ideo.config.annotationHeight;\n\n        const settingsGearWidth = 20;\n\n        if (ideo._layout._class === 'VerticalLayout') {\n          elementLength = ideoBounds.width - settingsGearWidth;\n          windowLength = window.innerWidth - settingsGearWidth;\n        } else {\n          elementLength = ideoBounds.height - 10;\n          windowLength = window.innerHeight - 10;\n        }\n\n        // Set chromosome height to window length or ideogram element length,\n        // whichever is smaller.  This keeps whole chromosome viewable, while\n        // also ensuring the height doesn't exceed what the user specified.\n        if (windowLength < elementLength) {\n          chrHeight = windowLength;\n        } else {\n          chrHeight = elementLength;\n        }\n        chrHeight -= ideo.config.chrMargin * 2;\n        ideo.config.chrHeight = chrHeight;\n\n        // Account for chromosome label\n        // TODO: Make this dynamic, not hard-coded\n        ideo.config.chrWidth *= 2.3;\n\n        ideo.config.annotationHeight *= 1.7;\n\n        ideo._layout.didRotate(chrIndex, chrElement);\n      });\n    }\n  }\n\n  getChromosomeLabelClass() {\n    if (this._config.ploidy === 1) {\n      return 'chrLabel';\n    } else {\n      return 'chrSetLabel';\n    }\n  }\n\n  _getAdditionalOffset() {\n    var config = this._config;\n    var numTracks = config.annotationsNumTracks || config.numAnnotTracks || 1;\n    return (config.annotationHeight || 0) * numTracks;\n  }\n\n  _getChromosomeSetSize(chrSetIndex) {\n    // Get last chromosome set size.\n    var setSize = this._ploidy.getSetSize(chrSetIndex);\n\n    // Increase offset by last chromosome set size\n    return (\n      setSize * this._config.chrWidth * 2 + (this.chrSetMargin)\n    );\n  }\n\n  // Get chromosome set label anchor property\n  getChromosomeSetLabelAnchor() {\n    return 'middle';\n  }\n\n  // Get chromosome label y position.\n  getChromosomeLabelYPosition() {\n    return -5.5;\n  }\n\n  getChromosomeSetLabelYPosition(chrIndex) {\n    if (this._config.ploidy === 1) {\n      return this.getChromosomeLabelYPosition(chrIndex);\n    } else {\n      return -2 * this._config.chrWidth;\n    }\n  }\n\n}\n\nexport default Layout;\n","/**\n* @fileoverview Vertical layout class\n* Ideogram instances with vertical layout are oriented with each chromosome\n* starting at top and ending at bottom, and aligned as columns.\n*/\n\nimport {d3} from '../lib';\nimport Layout from './layout';\n\nclass VerticalLayout extends Layout {\n\n  constructor(config, ideo) {\n    super(config, ideo);\n    this._class = 'VerticalLayout';\n    // Layout margins\n    this.margin = {\n      top: 30,\n      left: 15\n    };\n  }\n\n  rotateForward(chrSetIndex, chrIndex, chrElement, callback) {\n    // TODO: Integrate chrSetIndex and chrIndex to support polyploid rotation.\n\n    var self = this;\n\n    var xOffset = 20;\n\n    var scale = this.getChromosomeScale(chrElement);\n\n    var transform =\n      'translate(' + xOffset + ', 25) ' + scale;\n\n    d3.select(chrElement.parentNode)\n      .transition()\n      .attr('transform', transform)\n      .on('end', callback);\n\n    // Append new chromosome labels\n    var labels = this.getChromosomeLabels(chrElement);\n    var y = (xOffset + self._config.chrWidth) * 1.3;\n    d3.select(this._ideo.getSvg())\n      .append('g')\n      .attr('class', 'tmp')\n      .selectAll('text')\n      .data(labels)\n      .enter()\n      .append('text')\n      .attr('class', function(d, i) {\n        return i === 0 && labels.length === 2 ? 'chrSetLabel' : null;\n      })\n      .attr('x', 0)\n      .attr('y', y).style('opacity', 0)\n      .text(String)\n      .transition()\n      .style('opacity', 1);\n\n    this._ideo.config.orientation = 'horizontal';\n  }\n\n  rotateBack(setIndex, chrIndex, chrElement, callback) {\n\n    var scale = this.getChromosomeScaleBack(chrElement);\n    var translate = this.getChromosomeSetTranslate(setIndex);\n\n    d3.select(chrElement.parentNode)\n      .transition()\n      .attr('transform', translate + ' ' + scale)\n      .on('end', callback);\n\n    d3.selectAll(this._ideo.selector + ' g.tmp')\n      .style('opacity', 0)\n      .remove();\n\n    this._ideo.config.orientation = 'vertical';\n  }\n\n  getHeight() {\n    return this._config.chrHeight + this.margin.top * 1.5;\n  }\n\n  getWidth() {\n    return '97%';\n  }\n\n  getChromosomeBandTickY1() {\n    return 2;\n  }\n\n  getChromosomeBandTickY2() {\n    return 10;\n  }\n\n  getChromosomeSetLabelTranslate() {\n    return 'rotate(-90)';\n  }\n\n  getChromosomeBandLabelAnchor() {\n    return null;\n  }\n\n  getChromosomeScale(chrElement) {\n    var ideoBox, chrBox, scaleX, scaleY;\n\n    ideoBox = d3.select(this._ideo.selector).node().getBoundingClientRect();\n    chrBox = chrElement.getBoundingClientRect();\n\n    scaleX = (ideoBox.width / chrBox.height) * 0.97;\n    scaleY = this._getYScale();\n\n    return 'scale(' + scaleX + ', ' + scaleY + ')';\n  }\n\n  getChromosomeScaleBack(chrElement) {\n    var scale, scaleX, scaleY, chrName, chrModel, taxid, ideo, config;\n\n    ideo = this._ideo;\n    config = ideo.config;\n    taxid = config.taxid;\n\n    chrName = chrElement.id.split('-')[0].replace('chr', '');\n    chrModel = this._ideo.chromosomes[taxid][chrName];\n    scaleX = (chrModel.oldWidth / (config.chrHeight * 3)) * 0.97;\n    scaleY = 1 / this._getYScale();\n    scale = 'scale(' + scaleX + ', ' + scaleY + ')';\n    return scale;\n  }\n\n  getChromosomeSetTranslate(setIndex) {\n    var marginTop = this.margin.top;\n    var chromosomeSetYTranslate = this.getChromosomeSetYTranslate(setIndex);\n    return (\n      'rotate(90) ' +\n      'translate(' + marginTop + ', -' + chromosomeSetYTranslate + ')'\n    );\n  }\n\n  getChromosomeSetYTranslate(setIndex) {\n    // Get additional padding caused by annotation/histogram tracks\n    var pad = this._getAdditionalOffset(),\n      config = this._config,\n      margin = config.chrMargin,\n      width = config.chrWidth,\n      translate;\n\n    // If no detailed description provided just use one formula for all cases\n    if (!config.ploidyDesc) {\n      // TODO:\n      // This part of code contains a lot magic numbers and if\n      // statements for exactly corresponing to original ideogram examples.\n      // But all this stuff should be removed. Calculation of translate\n      // should be a simple formula applied for all cases listed below.\n      // Now they are diffirent because of Layout:_getAdditionalOffset do\n      // not meet for cases when no annotation, when annotation exists and\n      // when histogram used\n\n      if (config.annotationsLayout === 'histogram') {\n        var barWidth = config.barWidth;\n        return margin + setIndex * (margin + width + 3) + barWidth * 2;\n      } else {\n        const decorPad =\n          'legendPad' in config ? config.legendPad : 0;\n        translate = width + setIndex * (margin + width) + pad * 2 + decorPad;\n        if (pad > 0) {\n          return translate;\n        } else {\n          return translate + 4 + (2 * setIndex);\n        }\n      }\n    }\n\n    // If detailed description provided start to calculate offsets\n    // for each chromosome set separately. This should be done only once\n    if (!this._translate) {\n      // First offset equals to zero\n      this._translate = [this._ploidy.getSetSize(0) * width * 2];\n      var prevTranslate;\n      // Loop through description set\n      for (var i = 1; i < this._config.ploidyDesc.length; i++) {\n        prevTranslate = this._translate[i - 1];\n        this._translate[i] = prevTranslate + this._getChromosomeSetSize(i - 1);\n      }\n    }\n\n    return this._translate[setIndex];\n  }\n\n  getChromosomeSetLabelXPosition() {\n    return (this._config.chrWidth * this._config.ploidy) / -2;\n  }\n\n  getChromosomeLabelXPosition() {\n    return this._config.chrWidth / -2;\n  }\n}\n\nexport default VerticalLayout;\n","/**\n* @fileoverview Horizontal layout class\n* Ideogram instances with horizontal layout are oriented with each chromosome\n* starting at left and ending at right, and aligned as rows.\n*/\n\nimport {d3} from '../lib';\nimport Layout from './layout';\n\nclass HorizontalLayout extends Layout {\n\n  constructor(config, ideo) {\n    super(config, ideo);\n    this._class = 'HorizontalLayout';\n    this.margin = {\n      left: 20,\n      top: 30\n    };\n  }\n\n  _getLeftMargin() {\n    var margin = Layout.prototype._getLeftMargin.call(this);\n    if (this._config.ploidy > 1) {\n      margin *= 1.8;\n    }\n\n    return margin;\n  }\n\n  rotateForward(setIndex, chrIndex, chrElement, callback) {\n\n    var xOffset, yOffset, transform, labels;\n\n    xOffset = 30;\n\n    yOffset = xOffset + 7.5;\n\n    transform = (\n      'rotate(90) ' +\n      'translate(' + xOffset + ', -' + yOffset + ') '\n    );\n\n    d3.select(chrElement.parentNode)\n      .transition()\n      .attr('transform', transform)\n      .on('end', callback);\n\n    // Append new chromosome labels\n    labels = this.getChromosomeLabels(chrElement);\n    d3.select(this._ideo.getSvg())\n      .append('g')\n      .attr('class', 'tmp')\n      .selectAll('text')\n      .data(labels)\n      .enter()\n      .append('text')\n      .attr('class', function(d, i) {\n        return i === 0 && labels.length === 2 ? 'chrSetLabel' : null;\n      })\n      .attr('x', xOffset - 4)\n      .attr('y', function(d, i) {\n        return (i + 1 + labels.length % 2) * 12;\n      })\n      .style('text-anchor', 'middle')\n      .style('opacity', 0)\n      .text(String)\n      .transition()\n      .style('opacity', 1);\n\n    this._ideo.config.orientation = 'vertical';\n  }\n\n  rotateBack(setIndex, chrIndex, chrElement, callback) {\n    var translate = this.getChromosomeSetTranslate(setIndex);\n\n    d3.select(chrElement.parentNode)\n      .transition()\n      .attr('transform', translate)\n      .on('end', callback);\n\n    d3.selectAll(this._ideo.selector + ' g.tmp')\n      .style('opacity', 0)\n      .remove();\n\n    this._ideo.config.orientation = 'horizontal';\n  }\n\n  getHeight(taxid) {\n    if (typeof taxid === 'undefined') taxid = this._config.taxids[0];\n    // Get last chromosome set offset.\n    var numChromosomes = this._config.chromosomes[taxid].length;\n    var lastSetOffset = this.getChromosomeSetYTranslate(numChromosomes - 1);\n\n    // Get last chromosome set size.\n    var lastSetSize = this._getChromosomeSetSize(numChromosomes - 1);\n\n    // Increase offset by last chromosome set size\n    lastSetOffset += lastSetSize;\n\n    return lastSetOffset + this._getAdditionalOffset() * 2;\n  }\n\n  getWidth() {\n    return this._config.chrHeight + this.margin.top * 1.5;\n  }\n\n  getChromosomeSetLabelAnchor() {\n    return 'end';\n  }\n\n  getChromosomeBandLabelAnchor() {\n    return null;\n  }\n\n  getChromosomeBandTickY1() {\n    return 2;\n  }\n\n  getChromosomeBandTickY2() {\n    return 10;\n  }\n\n  getChromosomeSetLabelTranslate() {\n    return null;\n  }\n\n  getChromosomeSetTranslate(setIndex) {\n    var leftMargin = this._getLeftMargin();\n    var yTranslate = this.getChromosomeSetYTranslate(setIndex);\n    return 'translate(' + leftMargin + ', ' + yTranslate + ')';\n  }\n\n  getChromosomeSetYTranslate(setIndex) {\n    // If no detailed description provided just use one formula for all cases.\n    if (!this._config.ploidyDesc) {\n      return this._config.chrMargin * (setIndex + 1);\n    }\n\n    // Id detailed description provided start to calculate offsets\n    //  for each chromosome set separately. This should be done only once.\n    if (!this._translate) {\n      // First offset equals to zero.\n      this._translate = [1];\n\n      // Loop through description set\n      for (var i = 1; i < this._config.ploidyDesc.length; i++) {\n        this._translate[i] =\n          this._translate[i - 1] + this._getChromosomeSetSize(i - 1);\n      }\n    }\n\n    return this._translate[setIndex];\n  }\n\n  getChromosomeSetLabelXPosition(i) {\n    if (this._config.ploidy === 1) {\n      return this.getChromosomeLabelXPosition(i);\n    } else {\n      return -20;\n    }\n  }\n\n  getChromosomeSetLabelYPosition(i) {\n    var setSize = this._ploidy.getSetSize(i),\n      config = this._config,\n      chrMargin = config.chrMargin,\n      chrWidth = config.chrWidth,\n      y;\n\n    if (config.ploidy === 1) {\n      y = chrWidth / 2 + 3;\n    } else {\n      y = (setSize * chrMargin) / 2;\n    }\n\n    return y;\n  }\n\n  getChromosomeLabelXPosition() {\n    return -8;\n  }\n\n  getChromosomeLabelYPosition() {\n    return this._config.chrWidth;\n  }\n\n}\n\nexport default HorizontalLayout;\n","/**\n* @fileoverview Paired layout class\n* Ideograms with paired layout group each chromosome in a chromosome set.\n* This enables ploidy support beyond the default haploid; e.g. diploid genomes.\n*/\n\nimport Layout from './layout';\n\nclass PairedLayout extends Layout {\n\n  constructor(config, ideo) {\n    super(config, ideo);\n\n    this._class = 'PairedLayout';\n\n    this.margin = {\n      left: 30\n    };\n  }\n\n  getHeight() {\n    return this._config.chrHeight + this.margin.left * 1.5;\n  }\n\n  getWidth() {\n    return '97%';\n  }\n\n  getChromosomeBandTickY1(chrIndex) {\n    return chrIndex % 2 ? this._config.chrWidth : this._config.chrWidth * 2;\n  }\n\n  getChromosomeBandTickY2(chrIndex) {\n    var width = this._config.chrWidth;\n    return chrIndex % 2 ? width - this._tickSize : width * 2 + this._tickSize;\n  }\n\n  getChromosomeBandLabelAnchor(chrIndex) {\n    return chrIndex % 2 ? null : 'end';\n  }\n\n  getChromosomeBandLabelTranslate(band, chrIndex) {\n    var x = chrIndex % 2 ? 10 : -this._config.chrWidth - 10;\n    var y = this._ideo.round(band.px.start + band.px.width / 2) + 3;\n\n    return {\n      x: y,\n      y: y,\n      translate: 'rotate(-90) translate(' + x + ', ' + y + ')'\n    };\n  }\n\n  getChromosomeLabelXPosition() {\n    return -this._tickSize;\n  }\n\n  getChromosomeSetLabelXPosition() {\n    return this._config.chrWidth / -2;\n  }\n\n  getChromosomeSetLabelTranslate() {\n    return 'rotate(-90)';\n  }\n\n  getChromosomeSetTranslate(setIndex) {\n    var chromosomeSetYTranslate = this.getChromosomeSetYTranslate(setIndex);\n    return (\n      'rotate(90) ' +\n      'translate(' + this.margin.left + ', -' + chromosomeSetYTranslate + ')'\n    );\n  }\n\n  getChromosomeSetYTranslate(setIndex) {\n    return 200 * (setIndex + 1);\n  }\n\n}\n\nexport default PairedLayout;\n","import Layout from './layout';\n\nclass SmallLayout extends Layout {\n\n  constructor(config, ideo) {\n    super(config, ideo);\n\n    this._class = 'SmallLayout';\n\n    this.margin = {\n      left: 36.5,\n      top: 10\n    };\n\n    var taxid = this._ideo.getTaxid(this._ideo.config.organism);\n\n    this.chrs = config.chromosomes[taxid];\n    var numChrs = this.chrs.length;\n\n    // Number of chromosomes per row\n    this.chrsPerRow = Math.ceil(numChrs / config.rows);\n  }\n\n  // rotateForward(setIndex, chrIndex, chrElement, callback) {\n  //   var ideoBox =\n  //      d3.select(this._ideo.selector).node().getBoundingClientRect();\n  //   var chrBox = chrElement.getBoundingClientRect();\n  //\n  //   var scaleX = (ideoBox.width / chrBox.height) * 0.97;\n  //   var scaleY = this._getYScale();\n  //\n  //   transform = 'translate(5, 25) scale(' + scaleX + ', ' + scaleY + ')';\n  //\n  //   d3.select(chrElement.parentNode)\n  //     .transition()\n  //     .attr('transform', transform)\n  //     .on('end', callback);\n  // }\n  //\n  // rotateBack(setIndex, chrIndex, chrElement, callback) {\n  //   var translate = this.getChromosomeSetTranslate(setIndex);\n  //\n  //   d3.select(chrElement.parentNode)\n  //     .transition()\n  //     .attr('transform', translate)\n  //     .on('end', callback);\n  // }\n\n  /**\n   * eweitz 2020-04-13:\n   * This height metric is crude because it is calculated before\n   * the height (\"width\") of each chromosome is calculated.\n   *\n   * It calculates height by multiplying the max height of all chromosomes\n   * (specified in the Ideogram configuration object) by the number of rows.\n   * This ensures the ideogram height doesn't truncate in cases like dog\n   * (where chrX on the second row is longer than chr1 on the first), but it\n   * often leaves too much space on the second row, e.g. for human.\n   *\n   * Ideally, ideogram height would be cumulative height per row, plus top\n   * margin.  This would require calling getHeight _after_ all chromosomes\n   * have had their height (technically, chr.width) assigned.  See draft new\n   * getHeight method below this getHeight method.\n  */\n  getHeight() {\n    var config = this._config;\n    var chrHeight = config.chrHeight * 1.25;\n    return this._config.rows * (chrHeight + this.margin.top);\n  }\n\n  /**\n   * eweitz 2020-04-13:\n   * Draft refinement of getHeight.  See note in classic version above.\n   *\n   * Total height is cumulative height per row, plus top margin\n   */\n  // getHeight() {\n  //   let height = 0;\n  //   const rows = this._config.rows;\n  //   const chrEntries = Object.entries(this.chrs);\n\n  //   for (let i = 0; i < rows; i++) {\n  //     let rowHeight = 0;\n  //     // Starting and ending indexes of chromosomes of this row\n  //     const startIndex = this.chrsPerRow * i;\n  //     const endIndex = this.chrsPerRow * (i + 1) - 1;\n\n  //     for (let j = startIndex; j < endIndex; j++) {\n  //       const thisChrHeight = chrEntries[j][1].width;\n  //       if (thisChrHeight > rowHeight) {\n  //         rowHeight = thisChrHeight;\n  //       }\n  //     }\n  //     height += rowHeight + this.margin.top;\n  //   }\n\n  //   return height;\n  // }\n\n  getWidth() {\n    return '97%';\n  }\n\n  getChromosomeBandLabelTranslate() {\n\n  }\n\n  getChromosomeSetLabelTranslate() {\n    return 'rotate(-90)';\n  }\n\n  getChromosomeSetTranslate(setIndex) {\n    var xOffset, yOffset;\n\n    if (setIndex > this.chrsPerRow - 1) {\n      xOffset = this.margin.left + this._config.chrHeight * 1.3;\n      yOffset = this.getChromosomeSetYTranslate(setIndex - this.chrsPerRow);\n    } else {\n      xOffset = this.margin.left;\n      yOffset = this.getChromosomeSetYTranslate(setIndex);\n    }\n\n    return 'rotate(90) translate(' + xOffset + ', -' + yOffset + ')';\n  }\n\n  getChromosomeSetYTranslate(setIndex) {\n    // Get additional padding caused by annotation tracks\n    var additionalPadding = this._getAdditionalOffset() * 0.3;\n    // If no detailed description provided just use one formula for all cases\n    return (\n      this.margin.left * (setIndex) + this._config.chrWidth +\n      additionalPadding * 2 + additionalPadding * setIndex\n    );\n  }\n\n  getChromosomeSetLabelXPosition(setIndex) {\n    return (\n      ((this._ploidy.getSetSize(setIndex) * this._config.chrWidth + 20) / -2) +\n      (this._config.ploidy > 1 ? 0 : this._config.chrWidth)\n    );\n  }\n\n  getChromosomeLabelXPosition() {\n    return this._config.chrWidth / -2;\n  }\n\n}\n\nexport default SmallLayout;\n","import {d3} from '../lib';\nimport {Ploidy} from '../ploidy';\nimport {getLayout} from '../layouts/layout-adapter';\n\n/**\n * If ploidy description is a string, then convert it to the canonical\n * array format.  String ploidyDesc is used when depicting e.g. parental\n * origin each member of chromosome pair in a human genome.\n * See ploidy-basic.html for usage example.\n */\nfunction setPloidy(ideo) {\n  if (\n    'ploidyDesc' in ideo.config &&\n    typeof ideo.config.ploidyDesc === 'string'\n  ) {\n    var tmp = [];\n    for (var i = 0; i < ideo.numChromosomes; i++) {\n      tmp.push(ideo.config.ploidyDesc);\n    }\n    ideo.config.ploidyDesc = tmp;\n  }\n  // Organism ploidy description\n  ideo._ploidy = new Ploidy(ideo.config);\n}\n\nfunction getContainerSvgClass(ideo) {\n  var svgClass = '';\n  if (ideo.config.showChromosomeLabels) {\n    if (ideo.config.orientation === 'horizontal') {\n      svgClass += 'labeledLeft ';\n    } else {\n      svgClass += 'labeled ';\n    }\n  }\n\n  if (ideo.config.rotatable === false) {\n    svgClass += 'no-rotate ';\n  }\n\n  if (\n    ideo.config.annotationsLayout &&\n    ideo.config.annotationsLayout === 'overlay'\n  ) {\n    svgClass += 'faint';\n  }\n\n  return svgClass;\n}\n\n/**\n * Write tooltip div setup with default styling.\n */\nfunction writeTooltipContainer(ideo) {\n  d3.select(ideo.config.container + ' #_ideogramOuterWrap').append('div')\n    .attr('class', '_ideogramTooltip')\n    .attr('id', '_ideogramTooltip')\n    .style('opacity', 0)\n    .style('position', 'fixed')\n    .style('text-align', 'center')\n    .style('padding', '4px')\n    .style('font', '12px sans-serif')\n    .style('background', 'white')\n    .style('border', '1px solid black')\n    .style('border-radius', '5px')\n    .style('z-index', '1000');\n}\n\nfunction writeContainerDom(ideo) {\n\n  // Remove any previous container content\n  d3.selectAll(ideo.config.container + ' #_ideogramOuterWrap').remove();\n\n  d3.select(ideo.config.container)\n    .append('div')\n    .attr('id', '_ideogramOuterWrap')\n    .append('div')\n    .attr('id', '_ideogramTrackLabelContainer')\n    .style('position', 'absolute');\n\n  d3.select(ideo.config.container + ' #_ideogramOuterWrap').append('div')\n    .attr('id', '_ideogramMiddleWrap') // needed for overflow and scrolling\n    .style('position', 'relative')\n    .style('overflow-x', 'auto')\n    .style('transform', 'translateZ(0)') // add compositing layer for ideogram\n    .append('div')\n    .attr('id', '_ideogramInnerWrap') // needed for overflow and scrolling\n    .append('svg')\n    .attr('id', '_ideogram')\n    .attr('class', getContainerSvgClass(ideo))\n    .attr('width', ideo._layout.getWidth())\n    .attr('height', ideo._layout.getHeight())\n    .html(ideo.getBandColorGradients());\n}\n\n/**\n * Writes the HTML elements that contain this ideogram instance.\n */\nfunction writeContainer(t0) {\n  var ideo = this;\n\n  if (ideo.config.annotationsPath) {\n    ideo.fetchAnnots(ideo.config.annotationsPath);\n  }\n\n  setPloidy(ideo);\n\n  ideo._layout = getLayout(ideo);\n\n  writeContainerDom(ideo);\n\n  ideo.isOnlyIdeogram = document.querySelectorAll('#_ideogram').length === 1;\n  writeTooltipContainer(ideo);\n  ideo.finishInit(t0);\n}\n\nexport {writeContainer};\n","import VerticalLayout from './vertical-layout';\nimport HorizontalLayout from './horizontal-layout';\nimport PairedLayout from './paired-layout';\nimport SmallLayout from './small-layout';\n\nfunction getLayout(ideo) {\n  var config = ideo.config;\n\n  if ('perspective' in config && config.perspective === 'comparative') {\n    return new PairedLayout(config, ideo);\n  } else if ('rows' in config && config.rows > 1) {\n    return new SmallLayout(config, ideo);\n  } else if (config.orientation === 'vertical') {\n    return new VerticalLayout(config, ideo);\n  } else if (config.orientation === 'horizontal') {\n    return new HorizontalLayout(config, ideo);\n  } else {\n    return new VerticalLayout(config, ideo);\n  }\n}\n\nexport {getLayout};\n","import {hasNonGenBankAssembly, fetchWithRetry} from '../lib';\n\nvar lastBandDataUrl = '';\n\nfunction getBandUrl(bandDataFileNames, taxid, ideo) {\n  return ideo.config.dataDir + bandDataFileNames[taxid];\n}\n\nfunction shouldFetchBands(bandDataFileNames, taxid, ideo) {\n  var bandDataUrl = getBandUrl(bandDataFileNames, taxid, ideo);\n  return (\n    !(typeof window.chrBands !== 'undefined' && lastBandDataUrl === '') ||\n    lastBandDataUrl !== bandDataUrl\n  ) &&\n  hasNonGenBankAssembly(ideo) &&\n  taxid in bandDataFileNames;\n}\n\nfunction setBandData(url, fileNames, chrBands, ideo) {\n  var taxid, fetchedTaxid, fileName;\n\n  // Ensures correct taxid is processed in response callback;\n  // using simply upstream 'taxid' variable gives the last\n  // *requested* taxid, which fails when dealing with multiple taxa.\n  for (taxid in fileNames) {\n    fileName = fileNames[taxid];\n    if (url.includes(fileName) && fileName !== '') {\n      fetchedTaxid = taxid;\n    }\n  }\n\n  ideo.bandData[fetchedTaxid] = chrBands;\n}\n\nfunction fetchBands(bandDataFileNames, taxid, t0, ideo) {\n  var bandDataUrl = getBandUrl(bandDataFileNames, taxid, ideo);\n\n  if (!ideo.numBandDataResponses) ideo.numBandDataResponses = 0;\n\n  return fetchWithRetry(bandDataUrl)\n    .then(function(response) {\n      return response.json().then(function(rawBands) {\n        lastBandDataUrl = bandDataUrl;\n\n        delete window.chrBands; // Remove any previous chrBands variable\n        window.chrBands = rawBands.chrBands;\n\n        setBandData(response.url, bandDataFileNames, chrBands, ideo);\n      });\n    });\n}\n\nexport {shouldFetchBands, fetchBands};\n","/**\n * @fileoveriew Methods for initialization\n */\n\nimport {d3, slug} from '../lib';\nimport {configure} from './configure';\nimport {finishInit} from './finish-init';\nimport {writeContainer} from './write-container';\nimport {shouldFetchBands, fetchBands} from '../bands/fetch';\nimport {organismMetadata} from './organism-metadata';\n\nfunction isHeterogameticChromosome(chrModel, chrIndex, ideo) {\n  var ploidy = ideo.config.ploidy;\n  return (\n    'sex' in ideo.config &&\n      (\n        ploidy === 2 && ideo.sexChromosomes.index + 1 === chrIndex ||\n        ideo.config.sex === 'female' && chrModel.name === 'Y'\n      )\n  );\n}\n\nfunction prepareChromosomes(bandsArray, chrs, taxid, ideo) {\n  var j, bands, chromosome, chrModel, chrIndex;\n\n  for (j = 0; j < chrs.length; j++) {\n    chromosome = chrs[j];\n    if (typeof bandsArray !== 'undefined') bands = bandsArray[j];\n\n    chrIndex = j + ideo.config.taxids.indexOf(taxid);\n    chrModel = ideo.getChromosomeModel(bands, chromosome, taxid, chrIndex);\n\n    if (typeof chromosome !== 'string') {\n      chromosome = chromosome.name.split(' ').slice(-1)[0].replace('chr', '');\n    }\n\n    ideo.chromosomes[taxid][chromosome] = chrModel;\n    ideo.chromosomesArray.push(chrModel);\n\n    if (isHeterogameticChromosome(chrModel, j, ideo)) continue;\n\n    ideo.drawChromosome(chrModel);\n  }\n}\n\nfunction setCoordinateSystem(chrs, ideo) {\n  if (\n    typeof chrBands !== 'undefined' &&\n    chrs.length >= chrBands.length / 2\n  ) {\n    ideo.coordinateSystem = 'bp';\n  }\n}\n\n/**\n * Configures chromosome data and calls downstream chromosome drawing functions\n */\nfunction initDrawChromosomes() {\n  var taxid, i, chrs, bandsArray,\n    ideo = this,\n    taxids = ideo.config.taxids;\n\n  for (i = 0; i < taxids.length; i++) {\n    taxid = taxids[i];\n    chrs = ideo.config.chromosomes[taxid];\n\n    bandsArray = ideo.bandsArray[taxid];\n\n    if (!ideo.config.showNonNuclearChromosomes) {\n      // Remove MT\n      // TODO: Handle other non-nuclear chromosomes, e.g. CP, AP\n      chrs = chrs.filter(chr => chr !== 'MT');\n      if (typeof bandsArray !== 'undefined') {\n        bandsArray = bandsArray.filter(bands => {\n          return bands[0].chr !== 'MT';\n        });\n      }\n    }\n\n    setCoordinateSystem(chrs, ideo);\n\n    ideo.chromosomes[taxid] = {};\n    ideo.setSexChromosomes(chrs);\n\n    prepareChromosomes(bandsArray, chrs, taxid, ideo);\n\n    if (ideo.config.showBandLabels) ideo.drawBandLabels(ideo.chromosomes);\n    ideo.handleRotateOnClick();\n    ideo._gotChrModels = true; // Prevent issue with errant rat centromeres\n  }\n}\n\n/**\n * Attach any click handlers to rotate and toggle chromosomes\n */\nfunction handleRotateOnClick() {\n  var ideo = this;\n\n  if (!('rotatable' in ideo.config && ideo.config.rotatable === false)) {\n    d3.selectAll(ideo.selector + ' .chromosome-set').on('click', function() {\n      // Handles click on chromosome graphic or label.\n      // Label click needed to toggle e.g. human MT\n      const element = this.children[1];\n\n      ideo.rotateAndToggleDisplay(element);\n    });\n  } else {\n    d3.selectAll(ideo.selector).style('cursor', 'default');\n  }\n}\n\n/**\n * Called when Ideogram has finished initializing.\n * Accounts for certain ideogram properties not being set until\n * asynchronous requests succeed, etc.\n */\nfunction onLoad() {\n  call(this.onLoadCallback);\n}\n\nfunction getBandFileName(taxid, accession, ideo) {\n  var organism = ideo.organisms[taxid];\n  var bandFileName = [slug(organism.scientificName)];\n  var assemblies = organism.assemblies;\n  var resolution = ideo.config.resolution;\n\n  if (accession !== assemblies.default) {\n    bandFileName.push(accession);\n  }\n  if (\n    taxid === '9606' &&\n    (accession in assemblies === 'false' &&\n      Object.values(assemblies).includes(config.assembly) ||\n      (resolution !== '' && resolution !== 850))\n  ) {\n    bandFileName.push(resolution);\n  }\n\n  bandFileName = bandFileName.join('-');\n\n  var fullyBandedTaxids = ['9606', '10090', '10116'];\n  if (fullyBandedTaxids.includes(taxid) && !ideo.config.showFullyBanded) {\n    bandFileName += '-no-bands';\n  }\n\n  bandFileName += '.json';\n\n  return bandFileName;\n}\n\nfunction getBandFileNames(taxid, bandFileNames, ideo) {\n  var organism, assemblies, accession, bandFileName,\n    config = ideo.config;\n\n  organism = ideo.organisms[taxid];\n\n  if (!config.assembly) ideo.config.assembly = 'default';\n\n  assemblies = organism.assemblies;\n\n  if (ideo.assemblyIsAccession()) {\n    accession = config.assembly;\n  } else {\n    accession = assemblies[config.assembly];\n  }\n\n  bandFileName = getBandFileName(taxid, accession, ideo);\n  var isCustomOrganism = taxid === '-1';\n\n  if (taxid in ideo.organismsWithBands || isCustomOrganism) {\n    bandFileNames[taxid] = bandFileName;\n  }\n  return bandFileNames;\n}\n\nfunction prepareContainer(taxid, bandFileNames, t0, ideo) {\n\n  if (shouldFetchBands(bandFileNames, taxid, ideo)) {\n    return fetchBands(bandFileNames, taxid, t0, ideo).then(function() {\n      return ideo.processBandData(taxid);\n    });\n  } else {\n    return new Promise(function(resolve) {\n      ideo.processBandData(taxid);\n      resolve([taxid, undefined]);\n    });\n  }\n}\n\nfunction initializeTaxids(ideo) {\n  return new Promise(function(resolve) {\n    var organism = ideo.config.organism;\n    if (typeof organism === 'number') {\n      // 'organism' is a taxid, e.g. 9606\n      ideo.getOrganismFromEutils(organism, function() {\n        ideo.getTaxids(resolve);\n      });\n    } else {\n      ideo.getTaxids(resolve);\n    }\n\n  });\n}\n\nfunction getBandsAndPrepareContainer(taxids, t0, ideo) {\n  var bandFileNames, i, taxid,\n    promises = [];\n\n  bandFileNames = {};\n  for (taxid in organismMetadata) {\n    bandFileNames[taxid] = '';\n  }\n\n  for (i = 0; i < taxids.length; i++) {\n    taxid = String(taxids[i]);\n    bandFileNames = getBandFileNames(taxid, bandFileNames, ideo);\n    promises.push(prepareContainer(taxid, bandFileNames, t0, ideo));\n  }\n\n  Promise.all(promises).then(function(taxidsAndBandsArrays) {\n    var taxidAndBandsArray, taxid, bandsArray;\n\n    for (i = 0; i < taxidsAndBandsArrays.length; i++) {\n      taxidAndBandsArray = taxidsAndBandsArrays[i];\n      taxid = taxidAndBandsArray[0];\n      bandsArray = taxidAndBandsArray[1];\n\n      if ('bandsArray' in ideo === false) {\n        ideo.bandsArray = {};\n      }\n\n      ideo.bandsArray[taxid] = bandsArray;\n    }\n    ideo.writeContainer(t0);\n  });\n}\n\n/**\n * Initializes an ideogram.\n * Sets some high-level properties based on instance configuration,\n * fetches band and annotation data if needed, and\n * writes an SVG element to the document to contain the ideogram\n */\n// Prevents race condition when init is called multiple times in\n// quick succession.\n// See https://github.com/eweitz/ideogram/pull/154.\nvar ideoNext = {};\nvar ideoQueued = {};\nvar ideoWait = {};\n\nfunction init(ideo) {\n  ideo = ideo || this;\n  var containerId = ideo.config.container;\n\n  if (ideoWait[containerId]) {\n    ideoQueued[containerId] = true;\n    ideoNext[containerId] = ideo;\n  } else {\n    ideoWait[containerId] = true;\n    initializeTaxids(ideo)\n      .then(function(taxids) {\n\n        var taxid = taxids[0];\n        ideo.config.taxid = taxid;\n        ideo.config.taxids = taxids;\n\n        ideo.organismScientificName =\n          ideo.getScientificName(ideo.config.taxid);\n\n        var t0 = new Date().getTime();\n        getBandsAndPrepareContainer(taxids, t0, ideo);\n\n        ideoWait[containerId] = false;\n        if (ideoQueued[containerId]) {\n          ideoQueued[containerId] = false;\n          init(ideoNext[containerId]);\n        }\n      });\n  }\n}\n\nexport {\n  configure, initDrawChromosomes, handleRotateOnClick,\n  onLoad, init, finishInit, writeContainer\n};\n","/**\n * @fileoverview Parse raw Ideogram.js annotations from a BED file\n * BED documentation: https://genome.ucsc.edu/FAQ/FAQformat#format1\n */\n\nexport class BedParser {\n\n  constructor(bed, ideo) {\n    this.rawAnnots = this.parseBed(bed, ideo);\n  }\n\n  // http://stackoverflow.com/a/5624139\n  static componentToHex(c) {\n    var hex = parseInt(c, 10).toString(16);\n    return hex.length === 1 ? '0' + hex : hex;\n  }\n\n  static rgbToHex(r, g, b) {\n    return (\n      '#' +\n      BedParser.componentToHex(r) +\n      BedParser.componentToHex(g) +\n      BedParser.componentToHex(b)\n    );\n  }\n\n  parseGenomicCoordinates(columns, ucscStyle) {\n    var chr, start, stop, length;\n\n    // These three columns (i.e. fields) are required\n    chr = columns[0];\n    start = parseInt(columns[1], 10);\n    stop = parseInt(columns[2], 10);\n\n    length = stop - start;\n\n    if (ucscStyle) {\n      chr = chr.slice(3);\n    }\n\n    return [chr, start, stop, length];\n  }\n\n  /**\n   * Parses an annotation from a tab-separated line of a BED file\n   */\n  parseAnnotFromTsvLine(tsvLine, chrs, ucscStyle) {\n    var annot, chrIndex, chr, start, rgb, color, label,\n      columns = tsvLine.split(/\\s/g);\n\n    [chr, start, stop, length] =\n      this.parseGenomicCoordinates(columns, ucscStyle);\n\n    chrIndex = chrs.indexOf(chr);\n    if (chrIndex === -1) return [null, null];\n\n    annot = ['', start, length, 0];\n\n    if (columns.length >= 4) {\n      label = columns[3];\n      annot[0] = label;\n    }\n\n    if (columns.length >= 8) {\n      rgb = columns[8].split(',');\n      color = BedParser.rgbToHex(rgb[0], rgb[1], rgb[2]);\n      annot.push(color);\n    }\n\n    return [chrIndex, annot];\n  }\n\n  parseRawAnnots(annots, bedStartIndex, tsvLines, chrs) {\n    var i, line, chrIndex, annot, keys, rawAnnots, ucscStyle;\n\n    ucscStyle = true;\n    if (isNaN(parseInt(tsvLines[bedStartIndex], 10)) === false) {\n      ucscStyle = false;\n    }\n\n    for (i = bedStartIndex; i < tsvLines.length; i++) {\n      line = tsvLines[i];\n      [chrIndex, annot] = this.parseAnnotFromTsvLine(line, chrs, ucscStyle);\n      if (chrIndex !== null) annots[chrIndex].annots.push(annot);\n    }\n\n    keys = ['name', 'start', 'length', 'trackIndex'];\n    if (tsvLines[bedStartIndex].length >= 8) keys.push('color');\n\n    rawAnnots = {keys: keys, annots: annots};\n\n    return rawAnnots;\n  }\n\n  /**\n  * Parses a BED file, returns raw annotations\n  */\n  parseBed(bed, ideo) {\n    var i, chrs, chr, bedStartIndex, rawAnnots,\n      annots = [],\n      tsvLines = bed.split(/\\r\\n|\\n/);\n\n    chrs = Object.keys(ideo.chromosomes[ideo.config.taxid]);\n\n    for (i = 0; i < chrs.length; i++) {\n      chr = chrs[i];\n      annots.push({chr: chr, annots: []});\n    }\n\n    bedStartIndex = 0; // 1 if BED has header (i.e. track line), 0 otherwise\n    if (tsvLines[0].slice(0, 3) === 'chr' || isNaN(parseInt(tsvLines[0], 10))) {\n      bedStartIndex = 1;\n    }\n\n    rawAnnots = this.parseRawAnnots(annots, bedStartIndex, tsvLines, chrs);\n    return rawAnnots;\n  }\n\n}\n","/**\n * @fileoverview Parse raw Ideogram.js annotations from a TSV file\n */\n\nimport {camel} from './../lib';\n\nexport class TsvParser {\n\n  constructor(tsv, ideo) {\n    this.rawAnnots = this.parseTsv(tsv, ideo);\n  }\n\n  parseGenomicCoordinates(columns) {\n    // These three columns (i.e. fields) are required\n    const chr = columns[1];\n    const start = parseInt(columns[2], 10);\n    const length = parseInt(columns[3], 10);\n\n    return [chr, start, length];\n  }\n\n  /**\n  * Parses a TSV file, returns raw annotations\n  */\n  parseTsv(tsv, ideo) {\n    const lines = tsv.split(/\\r\\n|\\n/);\n\n    const chrs = Object.keys(ideo.chromosomes[ideo.config.taxid]);\n\n    const annots = [];\n\n    for (let i = 0; i < chrs.length; i++) {\n      const chr = chrs[i];\n      annots.push({chr, annots: []});\n    }\n\n    let headers;\n    const innerKeysByField = {};\n    const customHeaders = [];\n\n    const numRequired = 4;\n    // let numColumns;\n\n    for (let i = 0; i < lines.length; i++) {\n      const line = lines[i];\n      if (line === '') continue; // Skip empty lines\n\n      // Parse headers\n      if (line[0] === '#') {\n        if (line[1] === '#') {\n          // Parse inner field keys in metainformation lines\n          // E.g. ## differential_expression keys: gene;log2fc;pval_adj\n          const keySplit = line.split(' keys: ');\n          if (keySplit.length > 1) {\n            const field = keySplit[0].slice(3);\n            const keys = keySplit[1].split(';');\n            innerKeysByField[camel(field)] = keys;\n          }\n        } else {\n          // Slice/trim off \"# \", take columns 5 and onward, e.g.:\n          // full_name\\tmentions\\tdifferential_expression\\tinterest_rank\n          headers = line.slice(1).trim().split(/\\t/).map(h => camel(h));\n          // numColumns = headers.length;\n          const customs = headers.slice(numRequired);\n          customs.forEach((custom, i) => customHeaders.push(camel(custom)));\n        }\n        continue;\n      }\n\n      const columns = line.trim().split(/\\t/);\n      const name = columns[0];\n\n      const [chr, start, length] = this.parseGenomicCoordinates(columns);\n      const chrIndex = chrs.indexOf(chr);\n      if (chrIndex === -1) continue;\n\n      const customValues = columns.slice(numRequired);\n      for (let j = 0; j < numRequired; j++) {\n        const customHeader = customHeaders[j];\n        if (customHeader in innerKeysByField) {\n          const innerKeys = innerKeysByField[customHeader]\n          const block = columns[numRequired + j];\n          const group = block.split(';');\n          const customValue = [];\n          if (group[0] !== '') {\n            for (let k = 0; k < group.length; k++) {\n              const innerObj = {};\n              const innerValues = group[k].split('!');\n              for (let m = 0; m < innerValues.length; m++) {\n                const innerKey = innerKeys[m];\n                const innerValue = innerValues[m];\n                innerObj[camel(innerKey)] = innerValue;\n              }\n              customValue.push(innerObj);\n            }\n          }\n          customValues[j] = customValue;\n        }\n      }\n\n\n      const annot = [name, chr, start, length].concat(customValues);\n\n      annots[chrIndex].annots.push(annot);\n    };\n\n    const rawAnnots = {keys: headers, annots, innerKeysByField};\n    return rawAnnots;\n  }\n}\n","/**\n * @fileoverview Functions used by parallel and collinear heatmaps.\n */\n\nvar reservedTrackKeys = [\n  'name', 'start', 'length', 'trackIndex', 'trackIndexOriginal', 'color'\n];\n\nvar defaultHeatmapColors = {\n  3: ['00B', 'DDD', 'F00'],\n  5: ['00D', '66D', 'DDD', 'F88', 'F00'],\n  17: [\n    '00D', '00D', '00D', '00D', '00D', '44D', '44D', 'DDD', 'DDD',\n    'DDD', 'DDD', 'F88', 'F66', 'F22', 'F22', 'F00', 'F00', 'F00'\n  ]\n};\n\n/**\n * Get label text for displayed tracks from annotation container metadata,\n * heatmap keys, or annotation container keys\n */\nfunction getLabels(ideo) {\n  var annotKeys, labels, heatmaps, i;\n\n  if (ideo.rawAnnots.metadata && ideo.rawAnnots.metadata.trackLabels) {\n    labels = ideo.rawAnnots.metadata.trackLabels;\n  } else if (ideo.config.heatmaps) {\n    labels = [];\n    heatmaps = ideo.config.heatmaps;\n    for (i = 0; i < heatmaps.length; i++) {\n      labels.push(heatmaps[i].key);\n    }\n  } else {\n    annotKeys = ideo.rawAnnots.keys.slice(0);\n    labels = annotKeys.filter(d => !reservedTrackKeys.includes(d));\n  }\n\n  if (ideo.displayedTrackIndexes) {\n    labels = labels.filter(function(d, i) {\n      return ideo.displayedTrackIndexes.includes(i + 1);\n    });\n  }\n\n  return labels;\n}\n\n/**\n * Apply heatmap thresholds that are passed in as annotation metadata\n */\nfunction inflateThresholds(ideo) {\n  var thresholds, colors,\n    rawAnnots = ideo.rawAnnots;\n\n  if (\n    rawAnnots.metadata && !rawAnnots.metadata.heatmapThresholds &&\n    !ideo.config.heatmapThresholds\n  ) {\n    return;\n  }\n\n  if (ideo.config.heatmapThresholds) {\n    thresholds = ideo.config.heatmapThresholds;\n  } else {\n    thresholds = ideo.rawAnnots.metadata.heatmapThresholds;\n  }\n\n  colors = defaultHeatmapColors[thresholds.length + 1];\n  thresholds = thresholds.map((d, i) => {\n    return [d, '#' + colors[i]];\n  });\n\n  thresholds.push(['+', '#' + colors.slice(-1)[0]]);\n\n  return thresholds;\n}\n\n/**\n * Set needed configuration options from raw annotation data.\n * Simplifies heatmap API by inferring reasonable defaults.\n */\nfunction inflateHeatmaps(ideo) {\n  var i, labels, heatmaps, annotationTracks, rawAnnots, displayedTracks,\n    thresholds = ideo.config.heatmapThresholds;\n\n  heatmaps = [];\n  rawAnnots = ideo.rawAnnots;\n  labels = rawAnnots.keys.slice(3);\n\n  annotationTracks = [];\n  displayedTracks = [];\n  if (rawAnnots.metadata || !isNaN(thresholds[0])) {\n    thresholds = inflateThresholds(ideo);\n  }\n\n  for (i = 0; i < labels.length; i++) {\n    heatmaps.push({key: labels[i], thresholds: thresholds});\n    annotationTracks.push({id: labels[i]});\n    displayedTracks.push(i + 1);\n  }\n  ideo.config.annotationsNumTracks = labels.length;\n  ideo.config.annotationsDisplayedTracks = displayedTracks;\n  ideo.config.heatmaps = heatmaps;\n  ideo.config.annotationTracks = annotationTracks;\n}\n\n/**\n * Given annotation value (m), should it use the color in this threshold?\n */\nfunction shouldUseThresholdColor(m, numThresholds, value, prevThreshold,\n  threshold) {\n\n  return (\n    // If this is the last threshold, and\n    // its value is \"+\" and the value is above the previous threshold...\n    m === numThresholds && (\n      threshold === '+' && value > prevThreshold\n    ) ||\n\n    // ... or if the value matches the threshold...\n    value === threshold ||\n\n    // ... or if this isn't the first or last threshold, and\n    // the value is between this threshold and the previous one...\n    m !== 0 && m !== numThresholds && (\n      value <= threshold &&\n      value > prevThreshold\n    ) ||\n\n    // ... or if this is the first threshold and the value is\n    // at or below the threshold\n    m === 0 && value <= threshold\n  );\n}\n\n/**\n * Determine the color of the heatmap annotation.\n */\nfunction getHeatmapAnnotColor(thresholds, value) {\n  var m, numThresholds, thresholdList, threshold, tvNum, thresholdColor,\n    prevThreshold, useThresholdColor, color;\n\n  for (m = 0; m < thresholds.length; m++) {\n    numThresholds = thresholds.length - 1;\n    thresholdList = thresholds[m];\n    threshold = thresholdList[0];\n\n    // The threshold value is usually a number,\n    // but can also be a \"+\" character indicating that\n    // this threshold is anything greater than the previous threshold.\n    tvNum = parseFloat(threshold);\n    if (isNaN(tvNum) === false) threshold = tvNum;\n    if (m !== 0) prevThreshold = parseFloat(thresholds[m - 1][0]);\n    thresholdColor = thresholdList[1];\n\n    useThresholdColor = shouldUseThresholdColor(m, numThresholds, value,\n      prevThreshold, threshold);\n\n    if (useThresholdColor) color = thresholdColor;\n  }\n\n  return color;\n}\n\nexport {\n  getLabels, inflateHeatmaps, inflateThresholds, defaultHeatmapColors,\n  getHeatmapAnnotColor\n};\n","/**\n * @fileoverview Functions for collinear heatmaps of genome annotations.\n * See heatmap.js for more.\n */\n\nimport {d3} from '../lib';\nimport {writeTrackLabels} from './track-labels-collinear';\nimport {inflateHeatmaps} from './heatmap-lib';\n\n/**\n * Add canvases that will contain annotations.  One canvas per track.\n */\nfunction writeCanvases(chr, chrLeft, ideo) {\n  var j, trackLeft, trackWidth, canvas, context, id,\n    chrWidth = chr.width,\n    contextArray = [],\n    annotLabelHeight = ideo.config.annotLabelHeight,\n    numAnnotTracks = ideo.config.numAnnotTracks;\n\n  // Create a canvas for each annotation track on this chromosome\n  for (j = 0; j < numAnnotTracks; j++) {\n    trackWidth = ideo.config.annotationHeight + annotLabelHeight + 4;\n    id = chr.id + '-canvas-' + j; // e.g. chr1-9606-canvas-0\n    trackLeft = chrLeft;\n    if (chr.chrIndex > 0) {\n      trackLeft += (ideo.config.chrMargin * chr.chrIndex) - 1;\n    }\n    canvas = d3.select(ideo.config.container + ' #_ideogramInnerWrap')\n      .append('canvas')\n      .attr('id', id)\n      .attr('width', chrWidth + 1)\n      .attr('height', trackWidth)\n      .style('position', 'absolute')\n      .style('left', trackLeft + 'px')\n      .style('top', (trackWidth * j + 1) + 'px');\n    context = canvas.nodes()[0].getContext('2d');\n    contextArray.push([context, chr]);\n  }\n\n  return contextArray;\n}\n\n/**\n * Render annotations on the canvas\n */\nfunction fillCanvasAnnots(annots, contextArray, ideo) {\n  var j, annot, context, chr,\n    annotLabelHeight = ideo.config.annotLabelHeight,\n    annotHeight = ideo.config.annotationHeight,\n    demarcateChrs = ideo.config.demarcateCollinearChromosomes;\n\n  var trackWidth = annotHeight + annotLabelHeight + 4;\n\n  // Fill in the canvas(es) with annotation colors to draw a heatmap\n  for (j = 0; j < annots.length; j++) {\n    annot = annots[j];\n    context = contextArray[annot.trackIndex][0];\n    chr = contextArray[annot.trackIndex][1];\n    context.fillStyle = annot.color;\n    if (demarcateChrs) {\n      if (annot.startPx < 1 || annot.startPx > chr.width - 1) continue;\n      context.fillRect(annot.startPx, 1, 0.5, trackWidth);\n    } else {\n      context.fillRect(annot.startPx, annotLabelHeight + 1, 0.5, annotHeight);\n    }\n  }\n\n  if (demarcateChrs) {\n    for (j = 0; j < contextArray.length; j++) {\n      context = contextArray[j][0];\n      chr = contextArray[j][1];\n      context.fillStyle = '#555';\n      if (chr.chrIndex === 0) context.fillRect(0, 0, 1, trackWidth);\n      context.fillRect(chr.width - 1, 0, 1.1, trackWidth);\n      context.fillRect(0, 0, chr.width + 1, 1);\n      if (ideo.config.chrMargin) context.fillRect(0, 0, 1.1, trackWidth);\n    }\n  }\n}\n\n/**\n * Draw a 1D heatmap of annotations along each chromosome.\n * Ideal for representing very dense annotation sets in a granular manner\n * without subsampling.\n *\n * TODO:\n * - Support in 'vertical' orientation\n * - Support after rotating chromosome on click\n */\nfunction drawHeatmapsCollinear(annotContainers, ideo) {\n  var annots, chrLeft, contextArray, i, chr,\n    prevX = 0,\n    xBump = (ideo.config.showChromosomesLabels) ? 2 : -0.1;\n\n  d3.select(ideo.selector).classed('labeledLeft', false);\n  d3.selectAll(ideo.config.container + ' canvas').remove();\n\n  // Each \"annotationContainer\" represents annotations for a chromosome\n  for (i = 0; i < annotContainers.length; i++) {\n    annots = annotContainers[i].annots;\n    chr = ideo.chromosomesArray[i];\n    if (i === 0) {\n      chrLeft = 12;\n    } else {\n      chrLeft = prevX + ideo.chromosomesArray[i - 1].width + 14;\n      prevX += ideo.chromosomesArray[i - 1].width + xBump;\n    }\n    contextArray = writeCanvases(chr, chrLeft, ideo);\n    fillCanvasAnnots(annots, contextArray, ideo);\n  }\n\n  writeTrackLabels(ideo);\n\n  if (ideo.onDrawAnnotsCallback) ideo.onDrawAnnotsCallback();\n}\n\nexport {drawHeatmapsCollinear, inflateHeatmaps};\n","/**\n * @fileoverview Functions for 2D heatmaps of genome annotations.\n * 2D heatmaps enable showing many (100+) tracks of data in one dimension,\n * for features (e.g. genes) along a dimension of genomic coordinates in\n * chromosome context.\n *\n * TO DO:\n * - Horizontal orientation\n * - Multiple chromosomes\n * - Non-human organisms\n */\n\nimport {d3} from '../lib';\nimport {getHeatmapAnnotColor} from './heatmap-lib';\n\n/**\n * Add one canvas that will contain all annotations.  One canvas per chromosome.\n */\nfunction writeCanvas(chr, ideoHeight, width, ideo) {\n  var left, canvas, context, id;\n\n  id = chr.id + '-canvas'; // e.g. chr1-9606-canvas\n  left = (ideo.config.chrWidth * 2) + ideo.config.annotationHeight - 0.5;\n  canvas = d3.select(ideo.config.container + ' #_ideogramInnerWrap')\n    .append('canvas')\n    .attr('id', id)\n    .attr('width', width)\n    .attr('height', ideoHeight)\n    .style('position', 'absolute')\n    .style('left', left + 'px')\n    .style('top', '0px');\n  context = canvas.nodes()[0].getContext('2d');\n\n  return context;\n}\n\n/**\n * Render annotations on the canvas.\n *\n * These annotations are 2D; each annotation has many values, each on a track.\n */\nfunction fillCanvasAnnotValues(annot, context, ideo) {\n  var i, x, values,\n    annotHeight = ideo.config.annotationHeight,\n    ideoMarginTop = ideo._layout.margin.top;\n\n  values = annot.values;\n\n  // Fill canvas with annotation colors to draw the heatmap\n  for (i = 0; i < values.length; i++) {\n    context.fillStyle = values[i];\n    x = (i - 1) * annotHeight;\n    context.fillRect(x, annot.startPx + ideoMarginTop, annotHeight, 2);\n  }\n}\n\n/**\n * Draw a 2D heatmap of annotations along one chromosome.\n *\n * TODO:\n * - Support in 'horizontal' orientation\n * - Support after rotating chromosome on click\n */\nfunction drawHeatmaps2d(annotContainers, ideo) {\n  var annot, context, i, chr,\n    container = ideo.config.container,\n    ideoMarginTop = ideo._layout.margin.top,\n    ideoHeight = ideo.config.chrHeight + ideoMarginTop,\n    width = ideo.config.annotationHeight * annotContainers[0].values.length;\n\n  d3.selectAll(container + ' canvas').remove();\n\n  d3.select(container + ' #_ideogramInnerWrap')\n    .style('max-width', width + 'px');\n  d3.select(container + ' #_ideogram').attr('width', width);\n\n  chr = ideo.chromosomesArray[0];\n\n  context = writeCanvas(chr, ideoHeight, width, ideo);\n\n  // Each \"annotationContainer\" represents annotations for a chromosome\n  for (i = 0; i < annotContainers.length; i++) {\n    annot = annotContainers[i];\n    fillCanvasAnnotValues(annot, context, ideo);\n  }\n\n  if (ideo.onDrawAnnotsCallback) {\n    ideo.onDrawAnnotsCallback();\n  }\n}\n\nfunction add2dAnnotsForChr(annots, omittedAnnots, annotsByChr, chrModel,\n  m, keys, ideo) {\n  var j, k, annot, ra, stop, stopPx, color,\n    thresholds = ideo.config.heatmapThresholds;\n\n  for (j = 0; j < annotsByChr.annots.length; j++) {\n    ra = annotsByChr.annots[j];\n    annot = {};\n\n    annot.values = []; // one value per track\n\n    for (k = 0; k < 3; k++) {\n      annot[keys[k]] = ra[k];\n    }\n\n    for (k = 3; k < keys.length; k++) {\n      color = getHeatmapAnnotColor(thresholds, ra[k]);\n      annot.values.push(color);\n    }\n\n    stop = annot.start + annot.length;\n\n    annot.chr = annotsByChr.chr;\n    annot.chrIndex = m;\n    annot.startPx = ideo.convertBpToPx(chrModel, annot.start);\n    stopPx = ideo.convertBpToPx(chrModel, stop);\n    annot.px = Math.round((annot.startPx + stopPx) / 2);\n\n    annots.push(annot);\n  }\n\n  annots.shift();\n\n  return [annots, omittedAnnots];\n}\n\nexport {drawHeatmaps2d, add2dAnnotsForChr};\n","/**\n * @fileoverview Functions for labeling tracks of genome annotations.\n * Tracks are columns of annotations that run beside a chromosome.\n * Labeling tracks with descriptive names makes them easier to understand.\n */\n\nimport {d3} from '../lib';\nimport {getLabels} from './heatmap-lib';\n\n/**\n * Start a timer that, upon expiring, hides the track label.\n *\n * To enable users to copy label content to their clipboard, a timer is\n * used to control when the label disappears.  It starts when the user's\n * cursor leaves the track or the label.  If the user moves the cursor\n * back over the annot or label after the timer starts and before it expires,\n * then the timer is cleared.\n */\nfunction startHideTrackLabelTimeout(ideo) {\n  if (ideo.config.showTrackLabel === false) return;\n\n  ideo.hideTrackLabelTimeout = window.setTimeout(function() {\n    d3.select(ideo.config.container + ' #_ideogramTrackLabel').transition()\n      .duration(500)\n      .style('opacity', 0);\n  }, 250);\n}\n\n/**\n * Write label div setup with default styling.\n */\nfunction writeTrackLabelContainer(ideo) {\n  d3.select(ideo.config.container + ' #_ideogramTrackLabelContainer')\n    .append('div')\n    .attr('id', '_ideogramTrackLabel')\n    .style('opacity', 0)\n    .style('position', 'absolute')\n    .style('text-align', 'center')\n    .style('padding', '1px')\n    .style('font', '11px sans-serif')\n    .style('background', 'white')\n    .style('line-height', '10px')\n    .style('z-index', '9000');\n}\n\n/**\n * Display track labels on the page\n */\nfunction renderTrackLabels(top, left, ideo) {\n  d3.select(ideo.config.container + ' #_ideogramTrackLabel')\n    .style('opacity', 1) // Make label visible\n    .style('left', left + 'px')\n    .style('top', top + 'px')\n    .style('width', 'max-content')\n    .style('transform-origin', 'bottom left')\n    .style('text-align', 'left')\n    .on('mouseover', function() {\n      clearTimeout(ideo.hideTrackLabelTimeout);\n    })\n    .on('mouseout', function() {\n      startHideTrackLabelTimeout(ideo);\n    });\n}\n\n/**\n * Get left and top (x and y) offset for track label text\n */\nfunction getTrackLabelOffsets(labels, trackCanvas, ideo) {\n  var firstTrackId, firstTrack, trackBox, labelBox, ideoBox, left, top,\n    marginHack = 7; // TODO: Make this dynamic\n\n  firstTrackId = trackCanvas.id.split('-').slice(0, -1).join('-') + '-0';\n  firstTrack = d3.select(ideo.config.container + ' #' + firstTrackId)\n    .nodes()[0];\n  trackBox = firstTrack.getBoundingClientRect();\n\n  labelBox = d3.select(ideo.config.container + ' #_ideogramTrackLabel')\n    .nodes()[0].getBoundingClientRect();\n  ideoBox = d3.select(ideo.config.container).nodes()[0]\n    .getBoundingClientRect();\n\n  left = Math.round(trackBox.left + labelBox.width) - trackBox.width - 1;\n  left -= ideoBox.left - marginHack;\n  top = -(labels.split('<br>').length - 2) * trackBox.width + 2;\n\n  return [left, top];\n}\n\n/**\n * Show the label for this track\n */\nfunction showTrackLabel(trackCanvas, ideo) {\n  var labels, left, top;\n\n  clearTimeout(ideo.hideTrackLabelTimeout);\n\n  labels = getLabels(ideo);\n  labels = labels.join('<br>');\n\n  // Clear any previous positioning, write track label text to DOM\n  d3.select(ideo.config.container + ' #_ideogramTrackLabel')\n    .interrupt() // Stop any in-progress disapperance\n    .style('top', '')\n    .style('left', '')\n    .style('transform', null)\n    .style('transform', 'rotate(-90deg)')\n    .html(labels);\n\n  [left, top] = getTrackLabelOffsets(labels, trackCanvas, ideo);\n\n  renderTrackLabels(top, left, ideo);\n}\n\nexport {\n  startHideTrackLabelTimeout, writeTrackLabelContainer, showTrackLabel\n};\n","/**\n * @fileoverview Functions for 2D heatmaps of genome annotations.\n * Heatmaps provide an easy way to visualize very dense annotation data.\n * Unlike the rest of Ideogram's graphics, which use SVG, heatmaps are\n * rendered using the Canvas element.\n */\n\nimport {d3} from '../lib';\nimport {drawHeatmapsCollinear} from './heatmap-collinear';\nimport {drawHeatmaps2d} from './heatmap-2d';\nimport {getHeatmapAnnotColor} from './heatmap-lib';\n\nimport {\n  startHideTrackLabelTimeout, writeTrackLabelContainer, showTrackLabel\n} from './track-labels';\n\n/**\n * Add canvases that will contain annotations.  One canvas per track.\n */\nfunction writeCanvases(chr, chrLeft, ideoHeight, ideo) {\n  var j, trackLeft, trackWidth, canvas, context, id,\n    contextArray = [],\n    numAnnotTracks = ideo.config.numAnnotTracks;\n\n  var marginHack = 7; // TODO: Make this dynamic\n\n  // Create a canvas for each annotation track on this chromosome\n  for (j = 0; j < numAnnotTracks; j++) {\n    trackWidth = ideo.config.annotationHeight;\n    id = chr.id + '-canvas-' + j; // e.g. chr1-9606-canvas-0\n    trackLeft = chrLeft - trackWidth * (numAnnotTracks - j) - marginHack;\n    canvas = d3.select(ideo.config.container + ' #_ideogramInnerWrap')\n      .append('canvas')\n      .attr('id', id)\n      .attr('width', trackWidth)\n      .attr('height', ideoHeight)\n      .style('position', 'absolute')\n      .style('left', trackLeft + 'px');\n    context = canvas.nodes()[0].getContext('2d');\n    contextArray.push(context);\n  }\n\n  return contextArray;\n}\n\n/**\n * Render annotations on the canvas\n */\nfunction fillCanvasAnnots(annots, contextArray, chrWidth, ideoMarginTop) {\n  var j, annot, context, x;\n\n  // Fill in the canvas(es) with annotation colors to draw a heatmap\n  for (j = 0; j < annots.length; j++) {\n    annot = annots[j];\n    context = contextArray[annot.trackIndex];\n    context.fillStyle = annot.color;\n    x = annot.trackIndex - 1;\n    context.fillRect(x, annot.startPx + ideoMarginTop, chrWidth, 0.5);\n  }\n}\n\n/**\n * Draw a 1D heatmap of annotations along each chromosome.\n * Ideal for representing very dense annotation sets in a granular manner\n * without subsampling.\n *\n * TODO:\n * - Support in 'horizontal' orientation\n * - Support after rotating chromosome on click\n */\nfunction drawHeatmaps(annotContainers) {\n  var annots, chrLeft, contextArray, chrWidth, i, chr,\n    ideo = this,\n    config = ideo.config,\n    ideoMarginTop = ideo._layout.margin.top,\n    ideoHeight = config.chrHeight + ideoMarginTop;\n\n  if (config.geometry === 'collinear') {\n    return drawHeatmapsCollinear(annotContainers, ideo);\n  } else if (config.annotationsLayout === 'heatmap-2d') {\n    return drawHeatmaps2d(annotContainers, ideo);\n  }\n\n  d3.selectAll(ideo.config.container + ' canvas').remove();\n\n  writeTrackLabelContainer(ideo);\n\n  // Each \"annotationContainer\" represents annotations for a chromosome\n  for (i = 0; i < annotContainers.length; i++) {\n\n    annots = annotContainers[i].annots;\n    chr = ideo.chromosomesArray[i];\n    chrWidth = ideo.config.chrWidth;\n    chrLeft = ideo._layout.getChromosomeSetYTranslate(i);\n\n    contextArray = writeCanvases(chr, chrLeft, ideoHeight, ideo);\n    fillCanvasAnnots(annots, contextArray, chrWidth, ideoMarginTop);\n  }\n\n  d3.selectAll(ideo.config.container + ' canvas')\n    .on('mouseover', function() {showTrackLabel(this, ideo);})\n    .on('mouseout', function() {startHideTrackLabelTimeout(ideo);});\n\n  if (ideo.onDrawAnnotsCallback) {\n    ideo.onDrawAnnotsCallback();\n  }\n}\n\n/**\n * Set color and track index for raw annotation objects.\n */\nfunction getNewRawAnnots(heatmapKeyIndexes, rawAnnots, ideo) {\n  var j, k, ra, newRa, value, thresholds, color, trackIndex,\n    newRas = [];\n\n  for (j = 0; j < rawAnnots.length; j++) {\n    ra = rawAnnots[j];\n    for (k = 0; k < heatmapKeyIndexes.length; k++) {\n      newRa = ra.slice(0, 3); // name, start, length\n\n      value = ra[heatmapKeyIndexes[k]];\n      thresholds = ideo.config.heatmaps[k].thresholds;\n      color = getHeatmapAnnotColor(thresholds, value);\n\n      trackIndex = k;\n      newRa.push(trackIndex, color, value);\n      newRas.push(newRa);\n    }\n  }\n\n  return newRas;\n}\n\nfunction getNewRawAnnotContainers(heatmapKeyIndexes, rawAnnotBoxes, ideo) {\n  var raContainer, chr, rawAnnots, newRas, i,\n    newRaContainers = [];\n\n  for (i = 0; i < rawAnnotBoxes.length; i++) {\n    raContainer = rawAnnotBoxes[i];\n    chr = raContainer.chr;\n\n    rawAnnots = raContainer.annots;\n    newRas = getNewRawAnnots(heatmapKeyIndexes, rawAnnots, ideo);\n\n    newRaContainers.push({chr: chr, annots: newRas});\n  }\n  return newRaContainers;\n}\n\nfunction reportPerformance(t0, ideo) {\n  var t1 = new Date().getTime();\n  if (ideo.config.debug) {\n    console.log('Time in deserializeAnnotsForHeatmap: ' + (t1 - t0) + ' ms');\n  }\n}\n\n/**\n * Deserialize compressed annotation data into a format suited for heatmaps.\n *\n * This enables the annotations to be downloaded from a server without the\n * requested annotations JSON needing to explicitly specify track index or\n * color.  The track index and color are inferred from the \"heatmaps\" Ideogram\n * configuration option defined before ideogram initialization.\n *\n * This saves time for the user.\n *\n * @param rawAnnotsContainer {Object} Raw annotations as passed from server\n */\nfunction deserializeAnnotsForHeatmap(rawAnnotsContainer) {\n  var newRaContainers, heatmapKey, heatmapKeyIndexes, i,\n    t0 = new Date().getTime(),\n    keys = rawAnnotsContainer.keys,\n    rawAnnotBoxes = rawAnnotsContainer.annots,\n    ideo = this;\n\n  heatmapKeyIndexes = [];\n  for (i = 0; i < ideo.config.heatmaps.length; i++) {\n    heatmapKey = ideo.config.heatmaps[i].key;\n    heatmapKeyIndexes.push(keys.indexOf(heatmapKey));\n  }\n\n  newRaContainers =\n    getNewRawAnnotContainers(heatmapKeyIndexes, rawAnnotBoxes, ideo);\n\n  keys.splice(3, 0, 'trackIndex');\n  keys.splice(4, 0, 'color');\n\n  ideo.rawAnnots.keys = keys;\n  ideo.rawAnnots.annots = newRaContainers;\n\n  reportPerformance(t0, ideo);\n}\n\nexport {drawHeatmaps, deserializeAnnotsForHeatmap};\n","/**\n * @fileoverview Functions for labeling collinear tracks of genome annotations.\n * See track-labels.js for more.\n */\n\nimport {d3} from '../lib';\nimport {getLabels} from './heatmap-lib';\n\nfunction renderTrackLabels(labels, ideo) {\n  var i, x, y, labelContainer, markBump,\n    annotLabelHeight = ideo.config.annotLabelHeight,\n    demarcateChrs = ideo.config.demarcateCollinearChromosomes;\n\n  x = 11; // Close to chrLeft in heatmap-collinear.js.  For tabs.\n  markBump = (demarcateChrs ? 2 : 0); // Make labels flush with demarcations\n\n  labelContainer =\n    d3.select(ideo.config.container + ' #_ideogramTrackLabelContainer');\n  labelContainer.html('');\n\n  y = ideo.config.annotationHeight + annotLabelHeight + 4;\n\n  for (i = 0; i < labels.length; i++) {\n    labelContainer\n      .style('position', 'absolute')\n      .append('div')\n      .attr('class', '_ideogramTrackLabel')\n      .style('opacity', 1)\n      .style('position', 'absolute')\n      .style('text-align', 'center')\n      .style('padding', '1px')\n      .style('font', '11px sans-serif')\n      .style('background', 'white')\n      .style('line-height', '10px')\n      .style('z-index', '5')\n      .style('left', (x + markBump) + 'px')\n      .style('top', (y * i + markBump) + 'px')\n      .style('width', 'max-content')\n      .style('transform-origin', 'bottom left')\n      .style('text-align', 'left')\n      .html(labels[i]);\n  }\n\n}\n\n/**\n * Show the label for this track\n */\nfunction writeTrackLabels(ideo) {\n  var labels = getLabels(ideo);\n  renderTrackLabels(labels, ideo);\n}\n\nexport {writeTrackLabels};\n","import {d3, formatSiPrefix} from '../lib';\n// import {getShapes} from './draw';\n\n/**\n * Optional callback, invoked when annotations are drawn\n */\nfunction onLoadAnnots() {\n  call(this.onLoadAnnotsCallback);\n}\n\n/**\n * Optional callback, invoked when annotations are drawn\n */\nfunction onDrawAnnots() {\n  call(this.onDrawAnnotsCallback);\n}\n\nfunction hideAnnotTooltip() {\n  d3.select('._ideogramTooltip').transition()\n    .duration(500) // fade out for half second\n    .style('opacity', 0)\n    .style('pointer-events', 'none');\n}\n\n/**\n * Starts a timer that, upon expiring, hides the annotation tooltip.\n *\n * To enable users to copy tooltip content to their clipboard, a timer is\n * used to control when the tooltip disappears.  It starts when the user's\n * cursor leaves the annotation or the tooltip.  If the user moves the cursor\n * back over the annot or tooltip after the timer starts and before it expires,\n * then the timer is cleared.\n */\nfunction startHideAnnotTooltipTimeout() {\n  const ideo = this;\n\n  if (ideo.config.showAnnotTooltip === false) {\n    return;\n  }\n\n  // See \"Without this...\" note in gene-structure.js\n  const hideMs = ideo.oneTimeDelayTooltipHideMs ?? 250;\n  delete ideo.oneTimeDelayTooltipHideMs;\n\n  // Hide tooltip after `hideMs` milliseconds\n  ideo.hideAnnotTooltipTimeout = window.setTimeout(function() {\n    hideAnnotTooltip();\n  }, hideMs);\n\n  // Enable clients to not show tooltip immediately after clicking gene,\n  // e.g. in related genes kit\n  ideo.isTooltipCooling = true;\n  ideo.hideAnnotTooltipCounter = window.setTimeout(function() {\n    ideo.isTooltipCooling = false;\n  }, 500);\n}\n\nfunction renderTooltip(tooltip, content, matrix, yOffset, ideo) {\n  tooltip.html(content)\n    .style('opacity', 1) // Make tooltip visible\n    .style('left', matrix.e + 'px')\n    .style('top', (matrix.f - yOffset) + 'px')\n    .style('font-family', ideo.config.fontFamily)\n    .style('pointer-events', null) // Prevent bug in clicking chromosome\n    .on('mouseover', function() {\n      clearTimeout(ideo.hideAnnotTooltipTimeout);\n    })\n    .on('mouseout', function() {\n      ideo.startHideAnnotTooltipTimeout();\n    });\n}\n\nfunction getCoarseBpLength(annot) {\n  const length = Math.abs(annot.stop - annot.start);\n  return formatSiPrefix(length) + 'bp';\n}\n\nfunction getContentAndYOffset(annot, includeLength=false) {\n  var content, yOffset, range, displayName;\n\n  range = 'chr' + annot.chr + ':' + annot.start.toLocaleString();\n  if (annot.displayCoordinates) {\n    range = annot.displayCoordinates;\n  } else if (annot.length > 0) {\n    // Only show range if stop differs from start\n    range += '-' + annot.stop.toLocaleString();\n    if (includeLength) range += ' (' + getCoarseBpLength(annot) + ')';\n  }\n  content = `<span class=\"_ideoTooltipFooter\">${range}</span>`;\n  yOffset = 24;\n\n  if (annot.name) {\n    displayName = annot.displayName ? annot.displayName : annot.name;\n    content = displayName + '<br/>' + content;\n    yOffset += 8;\n  }\n\n  return [content, yOffset];\n}\n\n/**\n * Optional callback, invoked before showing annotation tooltip\n */\nfunction onWillShowAnnotTooltip(annot) {\n  call(this.onWillShowAnnotTooltipCallback, annot);\n}\n\nfunction onDidShowAnnotTooltip() {\n  call(this.onDidShowAnnotTooltipCallback);\n}\n\n/**\n * Optional callback, invoked on clicking annotation\n */\nfunction onClickAnnot(annot) {\n  this.prevClickedAnnot = annot;\n  this.onClickAnnotCallback(annot);\n}\n\n// /** Get list of annotation objects by names, e.g. [\"BRCA1\", \"APOE\"] */\n// function getAnnotsByName(annotNames, ideo) {\n//   return annotNames.map(name => getAnnotByName(name, ideo));\n// }\n\n/**\n * Shows a tooltip for the given annotation.\n *\n * See notes in startHideAnnotTooltipTimeout about show/hide logic.\n *\n * @param annot {Object} Processed annotation object\n * @param context {Object} \"This\" of the caller -- an SVG path DOM object\n */\nfunction showAnnotTooltip(annot, context) {\n  var matrix, content, yOffset, tooltip,\n    cx = Number(context.getAttribute('cx')),\n    cy = Number(context.getAttribute('cy')),\n    ideo = this;\n\n  if (ideo.config.showAnnotTooltip === false) return;\n\n  clearTimeout(ideo.hideAnnotTooltipTimeout);\n\n  if (ideo.onWillShowAnnotTooltipCallback) {\n    annot = ideo.onWillShowAnnotTooltipCallback(annot);\n  }\n\n  // Enable onWillShowAnnotTooltipCallback to cancel showing tooltip\n  if (annot === null) {\n    hideAnnotTooltip();\n    return;\n  }\n\n  ideo.prevTooltipAnnotName = annot.name;\n\n  tooltip = d3.select('._ideogramTooltip');\n  tooltip.interrupt(); // Stop any in-progress disapperance\n\n  matrix = context.getScreenCTM().translate(cx, cy);\n\n  const includeLength = true;\n  [content, yOffset] = getContentAndYOffset(annot, includeLength);\n\n  renderTooltip(tooltip, content, matrix, yOffset, ideo);\n\n  if (ideo.onDidShowAnnotTooltipCallback) {\n    ideo.onDidShowAnnotTooltipCallback();\n  }\n}\n\nexport {\n  onLoadAnnots, onDrawAnnots, startHideAnnotTooltipTimeout,\n  onWillShowAnnotTooltip, showAnnotTooltip, onClickAnnot,\n  onDidShowAnnotTooltip\n};\n","import {d3, getFont, getTextSize, deepCopy} from '../lib';\n\nimport {sortAnnotsByRank} from './annotations';\n\nconst allLabelStyle = `\n  <style>\n    #_ideogram .annot path, ._ideogramLabel {\n      cursor: pointer;\n    }\n\n    #_ideogram .annot path {\n      stroke-width: 1px;\n      stroke: white;\n      stroke-linejoin: bevel;\n    }\n\n    #_ideogram ._ideogramLabel._ideoActive {\n      fill: #77F !important;\n      stroke: #F0F0FF !important;\n    }\n\n    #_ideogram .annot > ._ideoActive {\n      stroke: #D0D0DD !important;\n      stroke-width: 1.5px;\n    }\n\n    #_ideogram ._ideogramLabel {\n      stroke: white;\n      stroke-width: 5px;\n      stroke-linejoin: round;\n      paint-order: stroke fill;\n      text-align: center;\n    }\n  </style>\n  `;\n\n/** Return DOM ID of annotation object */\nfunction getAnnotDomLabelId(annot) {\n  return 'ideogramLabel_' + annot.domId;\n}\n\nfunction changeAnnotState(state, labelId, annotId) {\n  d3.selectAll('._ideoActive').classed('_ideoActive', false);\n  d3.select('#' + labelId).attr('class', '_ideogramLabel ' + state);\n  d3.select('#' + annotId + ' > path').attr('class', state);\n}\n\nfunction triggerAnnotEvent(event, ideo) {\n  let labelId, annotId;\n  const target = event.target;\n  const type = event.type;\n\n  const targetClasses = Array.from(target.classList);\n  if (targetClasses.includes('_ideogramLabel')) {\n    labelId = target.id;\n    annotId = target.id.split('ideogramLabel_')[1];\n    d3.select('#' + annotId + ' path').dispatch(type);\n  } else {\n    const annotElement = target.parentElement;\n    labelId = 'ideogramLabel_' + annotElement.id;\n    annotId = annotElement.id;\n  }\n\n  if (type === 'mouseout') {\n    ideo.time.prevTooltipOff = performance.now();\n    ideo.time.prevTooltipAnnotDomId = annotId;\n  }\n\n  // On mouseover, activate immediately\n  // Otherwise, wait a moment (250 ms), then deactivate.\n  // Delayed deactivation mitigates flicker when moving from\n  // annot label to annot triangle.\n  if (type === 'mouseover') {\n    clearTimeout(window._ideoActiveTimeout);\n    changeAnnotState('_ideoActive', labelId, annotId);\n  } else {\n    window._ideoActiveTimeout = window.setTimeout(function() {\n      changeAnnotState('', labelId, annotId);\n    }, 250);\n  }\n}\n\nfunction renderLabel(annot, style, ideo) {\n\n  if (!ideo.didSetLabelStyle) {\n    document.querySelector('#_ideogramInnerWrap')\n      .insertAdjacentHTML('afterbegin', allLabelStyle);\n    ideo.didSetLabelStyle = true;\n  }\n\n  const id = getAnnotDomLabelId(annot);\n\n  const font = getFont(ideo);\n\n  const fill = annot.color === 'pink' ? '#CF406B' : annot.color;\n\n  d3.select('#_ideogram').append('text')\n    .attr('id', id)\n    .attr('class', '_ideogramLabel')\n    .attr('x', style.left)\n    .attr('y', style.top)\n    .style('font', font)\n    .style('fill', fill)\n    .style('pointer-events', null) // Prevent bug in clicking chromosome\n    .html(annot.name);\n}\n\n/** Get annotation object by name, e.g. \"BRCA1\" */\nfunction getAnnotByName(annotName, ideo) {\n  var annot;\n  var found = false;\n  ideo.annots.forEach((annotsByChr) => {\n    if (found) return;\n    annotsByChr.annots.forEach((thisAnnot) => {\n      if (found) return;\n      if (thisAnnot.name === annotName) {\n        annot = thisAnnot;\n        found = true;\n      }\n    });\n  });\n\n  return annot;\n}\n\n/** Get label's top and left offsets relative to chromosome, and width */\nfunction getAnnotLabelLayout(annot, ideo) {\n  var annotDom, annotRect, ideoRect, width, height, top, bottom, left, right,\n    config = ideo.config;\n\n  annotDom = document.querySelector('#' + annot.domId);\n\n  // Handles cases when annotation is not yet in DOM\n  if (annotDom === null) return null;\n\n  annotRect = annotDom.getBoundingClientRect();\n\n  ideoRect =\n    document.querySelector('#_ideogram').getBoundingClientRect();\n\n  const textSize = getTextSize(annot.name, ideo);\n  width = textSize.width;\n\n  // `pad` is a heuristic that accounts for:\n  // 1px left pad, 1px right pad, 1px right border, 1px left border\n  // as set in renderLabel\n  const pad = (config.fontFamily) ? 9 : 7;\n  width += pad;\n\n  const labelSize = config.annotLabelSize ? config.annotLabelSize : 13;\n\n  // Accounts for 1px top border, 1px bottom border as set in renderLabel\n  height = labelSize;\n\n  top = annotRect.top - ideoRect.top + height - 1;\n  bottom = top + height;\n  left = annotRect.left - ideoRect.left - width;\n  right = left + width;\n  name = annot.name;\n\n  return {top, bottom, right, left, width, height, name};\n}\n\n/**\n * Label an annotation.\n *\n * @param annotName {String} Name of annotation, e.g. \"BRCA1\"\n * @param backgroundColor {String} Background color.  Default: white.\n * @param backgroundColor {String} Border color.  Default: black.\n */\nfunction addAnnotLabel(annotName, backgroundColor, borderColor) {\n  var annot,\n    ideo = this;\n\n  annot = getAnnotByName(annotName, ideo);\n\n  const layout = getAnnotLabelLayout(annot, ideo);\n  if (layout === null) return;\n\n  const style = Object.assign(layout, {backgroundColor, borderColor});\n\n  renderLabel(annot, style, ideo);\n}\n\nfunction getIsXOverlap(o, n, p) {\n  const oLeft = o.left - p;\n  const nLeft = n.left - p;\n  const oRight = o.right + p;\n  const nRight = n.right + p;\n  // A) oLeft < nLeft && oLeft < nRight && oRight < nRight && oRight > nLeft\n  // o     o\n  // o     o\n  // o     o\n  //\n  //    n      n\n  //    n      n\n  //    n      n\n  //\n  // B) oLeft > nLeft && oLeft < nRight && oRight > nRight && oRight > nLeft\n  //    o     o\n  //    o     o\n  //    o     o\n  //\n  // n     n\n  // n     n\n  // n     n\n  //\n  // C) oLeft < nLeft && oLeft < nRight && oRight > nRight && oRight > nLeft\n  // o         o\n  // o         o\n  // o         o\n  //\n  //    n   n\n  //    n   n\n  //\n  // D) oLeft > nLeft && oLeft < nRight && oRight > nLeft && oRight < nRight\n  //    o   o\n  //    o   o\n  //    o   o\n  //\n  // n         n\n  // n         n\n  // n         n\n  return (\n    (oLeft <= nLeft && oLeft <= nRight && oRight <= nRight && oRight >= nLeft) ||\n    (oLeft >= nLeft && oLeft <= nRight && oRight >= nRight && oRight >= nLeft) ||\n    (oLeft <= nLeft && oLeft <= nRight && oRight >= nRight && oRight >= nLeft) ||\n    (oLeft >= nLeft && oLeft <= nRight && oRight >= nLeft && oRight <= nRight)\n  )\n}\n\nfunction getIsYOverlap(o, n, p) {\n    const oTop = o.top - p;\n    const nTop = n.top - p;\n    const oBottom = o.bottom + p;\n    const nBottom = n.bottom + p;\n    // Top of old annot (o) is above bottom of new annot (n),\n    // and bottom of old annot is below top of new annot\n    //\n    //  A) yOverlap = true\n    //      o.top < n.top && o.top < n.bottom && o.bottom < n.bottom && o.bottom > n.top\n    //    ooooo\n    //            nnnnn\n    //\n    //    ooooo\n    //            nnnnn\n    //\n    //  A.2)\n    //\n    //    ppppp\n    //    ppppp\n    //    ooooo\n    //\n    //            ppppp\n    //    ooooo   ppppp\n    //    ppppp   nnnnn\n    //    ppppp\n    //\n    //            nnnnn\n    //            ppppp\n    //            ppppp\n    //\n    //  B) yOverlap = true\n    //     o.top > n.top && o.top < n.bottom && o.bottom > n.bottom && o.bottom > n.top\n    //            nnnnn\n    //    ooooo\n    //\n    //            nnnnn\n    //    ooooo\n    //\n    //   B.2)\n    //\n    //            ppppp\n    //    ppppp   ppppp\n    //    ppppp   nnnnn\n    //    ooooo\n    //\n    //            nnnnn\n    //    ooooo   ppppp\n    //    ppppp   ppppp\n    //    ppppp\n    //\n    //\n    //  C) yOverlap = false\n    //     old.top < new.top && old.bottom < new.top\n    //    ooooo\n    //\n    //\n    //    ooooo\n    //\n    //          nnnnn\n    //\n    //\n    //          nnnnn\n    //\n    //  D) yOverlap = false\n    //          nnnnn\n    //\n    //\n    //          nnnnn\n    //\n    //    ooooo\n    //\n    //\n    //    ooooo\n    // sl.top - p < layout.bottom && sl.bottom > layout.top - p ||\n    // layout.top - p < sl.bottom && layout.bottom > sl.bottom\n\n    // XY overlap\n    // A)\n    //\n    //  ooooooo\n    //  o     o\n    //  o    nonnnnn\n    //  ooooooo    n\n    //       n     n\n    //       nnnnnnn\n    //\n    //\n    //  B)\n    //       ooooooo\n    //       o     o\n    //  nnnnnnn    o\n    //  n    onooooo\n    //  n     n\n    //  nnnnnnn\n    //\n    //  C)\n    //\n    //  ooooooo   nnnnnnn\n    //  o     o   n     n\n    //  o     o   n     n\n    //  ooooooo   nnnnnnn\n    //\n    //  D)\n    //\n    //  ooooooo\n    //  o     o\n    //  o     o\n    //  ooooooo\n    //\n    //  nnnnnnn\n    //  n     n\n    //  n     n\n    //  nnnnnnn\n    return (\n      // false\n      (oTop <= nTop && oTop <= nBottom && oBottom <= nBottom && oBottom >= nTop) ||\n      (oTop >= nTop && oTop <= nBottom && oBottom >= nBottom && oBottom >= nTop)\n    );\n\n    // (sl.top - p < layout.bottom || sl.bottom > layout.top - p) &&\n    // (layout.top - p < sl.bottom || layout.bottom > sl.bottom)\n}\n\n/** Label as many annotations as possible, without overlap */\nfunction fillAnnotLabels(sortedAnnots=[]) {\n  const ideo = this;\n\n  sortedAnnots = deepCopy(sortedAnnots); // copy by value\n\n  // Remove any pre-existing annotation labels, to avoid duplicates\n  ideo.clearAnnotLabels();\n\n  let spacedAnnots = [];\n  const spacedLayouts = [];\n\n  // sortedAnnots = applyRankCutoff(sortedAnnots, 100, ideo);\n\n  // sortedAnnots = sortedAnnots.sort(ideo.annotSortFunction);\n\n  if (sortedAnnots.length === 0) {\n    sortedAnnots = ideo.flattenAnnots();\n  }\n\n  const strokeWidth = 0; // like padding\n\n  sortedAnnots.forEach((annot, i) => {\n    const layout = getAnnotLabelLayout(annot, ideo);\n\n    if (layout === null) {\n      console.debug(annot.name + ' has null layout');\n      return;\n    }\n\n    const hasOverlap =\n      spacedLayouts.length > 0 && spacedLayouts.some((sl, j) => {\n        const xOverlap = getIsXOverlap(sl, layout, strokeWidth);\n        const yOverlap = getIsYOverlap(sl, layout, strokeWidth);\n\n        // if (annot.name === 'AKT1' || annot.name === 'XRCC3') {\n        //   const spacedAnnot = spacedAnnots[j].name;\n        //   if (spacedAnnot === 'HIF1A' || spacedAnnot === 'RAD51') {\n        //   // if (xOverlap && yOverlap) {\n        //     // console.log('sl.top - strokeWidth', sl.top - strokeWidth)\n        //     // console.log('sl.top - strokeWidth < layout.bottom')\n        //     // console.log(sl.top - strokeWidth < layout.bottom)\n        //     // console.log('sl.bottom > layout.top - strokeWidth')\n        //     // console.log(sl.bottom > layout.top - strokeWidth)\n        //     // console.log('layout.top - strokeWidth < sl.bottom')\n        //     // console.log(layout.top - strokeWidth < sl.bottom)\n        //     // console.log('layout.bottom > sl.bottom')\n        //     // console.log(layout.bottom > sl.bottom)\n        //     console.log(\n        //       'xOverlap, yOverlap, spacedAnnot, sl, annot.name, layout'\n        //     );\n        //     console.log(\n        //       xOverlap, yOverlap, spacedAnnot, sl, annot.name, layout\n        //     );\n        //   }\n        // }\n\n        // if (xOverlap && yOverlap) {\n        //   console.log('overlap! annot');\n        //   console.log(annot.name, annot.chr, annot.color);\n        // }\n        return xOverlap && yOverlap;\n      });\n\n    if (hasOverlap) return;\n\n    spacedAnnots.push(annot);\n    spacedLayouts.push(layout);\n  });\n\n  let numLabels = 10;\n  const config = ideo.config;\n  if ('relatedGenesMode' in config && config.relatedGenesMode === 'hints') {\n    numLabels = 20;\n  }\n  // spacedAnnots = applyRankCutoff(spacedAnnots, numLabels, ideo);\n  spacedAnnots = spacedAnnots.sort(ideo.annotSortFunction).slice(0, numLabels)\n\n\n  // Ensure highest-ranked annots are ordered last in SVG,\n  // to ensure the are written before lower-ranked annots\n  // (which, due to SVG z-index being tied to layering)\n  spacedAnnots.reverse();\n\n  spacedAnnots.forEach((annot) => {\n    ideo.addAnnotLabel(annot.name);\n  });\n\n  d3.selectAll('._ideogramLabel, .annot')\n    .on('mouseover', (event) => triggerAnnotEvent(event))\n    .on('mouseout', (event) => triggerAnnotEvent(event, ideo))\n    .on('click', (event) => triggerAnnotEvent(event));\n}\n\nfunction removeAnnotLabel(annotName) {\n  const ideo = this;\n  const annot = getAnnotByName(annotName, ideo);\n  const id = getAnnotDomLabelId(annot);\n  document.querySelector('#' + id).remove();\n}\n\nfunction clearAnnotLabels() {\n  const labels = document.querySelectorAll('._ideogramLabel');\n  labels.forEach((label) => {label.remove();});\n}\n\nexport {\n  addAnnotLabel, clearAnnotLabels, fillAnnotLabels, getAnnotLabelLayout,\n  removeAnnotLabel\n};\n","/**\n * Get containers to group individual annotations into higher-level \"bar\"\n * annotations.\n */\nfunction getRawBars(chrModels, ideo) {\n  var chr, chrModel, lastBand, numBins, bar, h, i, px,\n    barWidth = ideo.config.barWidth,\n    bars = [];\n\n  for (h = 0; h < ideo.chromosomesArray.length; h++) {\n    chr = ideo.chromosomesArray[h].name;\n    chrModel = chrModels[chr];\n    lastBand = chrModel.bands[chrModel.bands.length - 1];\n    numBins = Math.round(lastBand.px.stop / barWidth); // chrPxStop / barWidth\n    bar = {chr: chr, annots: []};\n\n    for (i = 0; i < numBins; i++) {\n      px = i * barWidth - ideo.bump;\n      bar.annots.push({\n        bp: ideo.convertPxToBp(chrModel, px + ideo.bump),\n        px: px,\n        count: 0,\n        chrIndex: chrModel.chrIndex,\n        chrName: chr,\n        color: ideo.config.annotationsColor,\n        annots: []\n      });\n    }\n    bars.push(bar);\n  }\n  return bars;\n}\n\n/**\n * Assign how many, and which annotations each histogram bar contains\n */\nfunction assignAnnotsToBars(annots, bars, chrModels, ideo) {\n  var chrAnnots, chrModel, barAnnots, h, i, annot, px, j, barPx, nextBarPx,\n    barWidth = ideo.config.barWidth;\n\n  for (h = 0; h < annots.length; h++) {\n    chrAnnots = annots[h].annots;\n    chrModel = chrModels[annots[h].chr]; // get chr by name\n    barAnnots = bars[chrModel.chrIndex].annots;\n    for (i = 0; i < chrAnnots.length; i++) {\n      annot = chrAnnots[i];\n      px = annot.px - ideo.bump;\n      for (j = 0; j < barAnnots.length; j++) {\n        barPx = barAnnots[j].px;\n        nextBarPx = barPx + barWidth;\n        if (j === barAnnots.length - 1) nextBarPx += barWidth;\n        if (px >= barPx && px < nextBarPx) {\n          bars[chrModel.chrIndex].annots[j].count += 1;\n          bars[chrModel.chrIndex].annots[j].annots.push(annot);\n          break;\n        }\n      }\n    }\n  }\n  return bars;\n}\n\nfunction setIdeoMaxAnnotsPerBar(bars, isFirstGet, ideo) {\n  var maxAnnotsPerBarAllChrs, i, maxAnnotsPerBar, annots, chr, j, barCount;\n\n  if (isFirstGet || ideo.config.histogramScaling === 'relative') {\n    maxAnnotsPerBarAllChrs = 0;\n    for (i = 0; i < bars.length; i++) {\n      maxAnnotsPerBar = 0;\n      annots = bars[i].annots;\n      chr = bars[i].chr;\n      for (j = 0; j < annots.length; j++) {\n        barCount = annots[j].count;\n        if (barCount > maxAnnotsPerBar) maxAnnotsPerBar = barCount;\n        if (barCount > maxAnnotsPerBarAllChrs) {\n          maxAnnotsPerBarAllChrs = barCount;\n        }\n      }\n      ideo.maxAnnotsPerBar[chr] = maxAnnotsPerBar;\n    }\n    ideo.maxAnnotsPerBarAllChrs = maxAnnotsPerBarAllChrs;\n  }\n}\n\n/**\n * Set each bar's height to be proportional to the height of the bar with the\n * most annotations\n */\nfunction setProportionalBarHeight(bars, ideo) {\n  var i, annots, chr, j, barCount, barCountRatio, height,\n    ideoIsRotated = ideo._layout._isRotated;\n\n  for (i = 0; i < bars.length; i++) {\n    annots = bars[i].annots;\n    chr = bars[i].chr;\n    for (j = 0; j < annots.length; j++) {\n      barCount = annots[j].count;\n      if (ideo.config.histogramScaling === 'relative') {\n        barCountRatio = barCount / ideo.maxAnnotsPerBar[chr];\n      } else {\n        barCountRatio = barCount / ideo.maxAnnotsPerBarAllChrs;\n      }\n      if (ideoIsRotated === false) {\n        height = barCountRatio * ideo.config.chrMargin;\n      } else {\n        height = barCountRatio * ideo.config.chrHeightOriginal * 3;\n      }\n      if (isNaN(height)) {\n        height = 0;\n      }\n      bars[i].annots[j].height = height;\n    }\n  }\n  return bars;\n}\n\nfunction reportGetHistogramBarPerformance(t0, ideo) {\n  var t1 = new Date().getTime();\n  if (ideo.config.debug) {\n    console.log('Time spent in getHistogramBars: ' + (t1 - t0) + ' ms');\n  }\n}\n\nfunction setIdeoHistogramScaling(ideo) {\n  if ('histogramScaling' in ideo.config === false) {\n    ideo.config.histogramScaling = 'absolute';\n  }\n}\n\n/**\n * Returns and sets bars used for histogram\n */\nfunction getHistogramBars(annots) {\n  var chrModels, bars,\n    isFirstGet = false,\n    t0 = new Date().getTime(),\n    ideo = this;\n\n  chrModels = ideo.chromosomes[ideo.config.taxid];\n\n  setIdeoHistogramScaling(ideo);\n\n  if (typeof ideo.maxAnnotsPerBar === 'undefined') {\n    ideo.maxAnnotsPerBar = {};\n    isFirstGet = true;\n  }\n\n  bars = getRawBars(chrModels, ideo);\n  bars = assignAnnotsToBars(annots, bars, chrModels, ideo);\n\n  setIdeoMaxAnnotsPerBar(bars, isFirstGet, ideo);\n  bars = setProportionalBarHeight(bars, ideo);\n\n  reportGetHistogramBarPerformance(t0, ideo);\n  ideo.bars = bars;\n  return bars;\n}\n\nfunction getHistogramPoints(d, chrWidth, chrWidths, ideo) {\n  var x1, x2, y1, y2;\n\n  x1 = d.px + ideo.bump;\n  x2 = d.px + ideo.config.barWidth + ideo.bump;\n  y1 = chrWidth;\n  y2 = chrWidth + d.height;\n\n  var thisChrWidth = chrWidths[d.chr];\n\n  if (x2 > thisChrWidth) {\n    x2 = thisChrWidth;\n  }\n\n  return (\n    x1 + ',' + y1 + ' ' +\n    x2 + ',' + y1 + ' ' +\n    x2 + ',' + y2 + ' ' +\n    x1 + ',' + y2\n  );\n}\n\nfunction writeHistogramAnnots(chrAnnot, ideo) {\n  var chrs, chr,\n    chrWidths = {},\n    chrWidth = ideo.config.chrWidth;\n\n  chrs = ideo.chromosomes[ideo.config.taxid];\n  for (chr in chrs) {\n    chrWidths[chr] = chrs[chr];\n  }\n\n  chrAnnot.append('polygon')\n    // .attr('id', function(d, i) { return d.id; })\n    .attr('class', 'annot')\n    .attr('points', function(d) {\n      return getHistogramPoints(d, chrWidth, chrWidths, ideo);\n    })\n    .attr('fill', function(d) {return d.color;});\n}\n\nexport {getHistogramBars, writeHistogramAnnots};\n","/**\n * @fileoverview Functions for drawing a legend for genome annotations.\n * A legend consists of rows, each with a colored icon and a text label.\n * Icons may have different shapes.  A legend may also have a name.\n */\n\nimport {d3, getTextSize, round} from '../lib';\n\nvar legendStyle =\n  '#_ideogramLegend {font: 12px Arial; overflow: auto;} ' +\n  '#_ideogramLegend svg {float: left;} ' +\n  '#_ideogramLegend ul {' +\n    'position: relative; left: -14px; list-style: none; float: left; ' +\n    'padding-left: 10px; margin: 0 0 1em 0; width: auto; border: none;' +\n  '} ' +\n  '#_ideogramLegend li {float: none; margin: 0;}' +\n  '#_ideogramLegend ul span {position: relative; left: -15px;} ';\n\nexport function getIcon(row, ideo) {\n  var icon, triangleAttrs, circleAttrs, rectAttrs,\n    fill = 'fill=\"' + row.color + '\" style=\"stroke: #AAA;\"',\n    shape = row.shape;\n\n  triangleAttrs = 'd=\"m7,3 l -5 9 l 9 0 z\"';\n  circleAttrs = 'd=\"m2,9a 4.5,4.5 0 1,0 9,0a 4.5,4.5 0 1,0 -9,0\"';\n  rectAttrs = 'height=\"10\" width=\"10\"  y=\"3\"';\n\n  if ('shape' in row && ['circle', 'triangle'].includes(shape)) {\n    if (shape === 'circle') {\n      icon = '<path ' + circleAttrs + ' ' + fill + '></path>';\n    } else if (shape === 'triangle') {\n      var transform = '';\n      if (ideo.config.orientation === 'vertical') {\n        // Orient arrows in legend as they are in annotations\n        transform = ' transform=\"rotate(90, 7, 7)\"';\n      }\n      if (ideo.config.orientation === 'down') {\n        transform = ' transform=\"rotate(180, 7, 7)\"';\n      }\n      icon = '<path ' + triangleAttrs + transform + ' ' + fill + '></path>';\n    }\n  } else {\n    icon = '<rect ' + rectAttrs + ' ' + fill + '/>';\n  }\n\n  return icon;\n}\n\nfunction getListItems(labels, svg, list, nameHeight, ideo) {\n  var i, icon, y, row,\n    lineHeight = getLineHeight(ideo);\n\n  for (i = 0; i < list.rows.length; i++) {\n    row = list.rows[i];\n    labels += '<li>' + row.name + '</li>';\n    y = lineHeight * (i - 1) + nameHeight + 1;\n    if ('name' in list) y += lineHeight;\n    icon = getIcon(row, ideo);\n    const transform = 'translate(0, ' + y + ')';\n    svg += '<g transform=\"' + transform + '\">' + icon + '</g>';\n  }\n\n  return [labels, svg];\n}\n\nfunction getLineHeight(ideo) {\n  return round(getTextSize('A', ideo).height) * 2 + 0.5;\n}\n\n/**\n * Display a legend for genome annotations, using `legend` configuration option\n */\nfunction writeLegend(ideo) {\n  var i, legend, svg, labels, list, content,\n    config = ideo.config,\n    lineHeight = getLineHeight(ideo);\n\n  d3.select(config.container + ' #_ideogramLegend').remove();\n\n  legend = config.legend;\n  content = '';\n\n  for (i = 0; i < legend.length; i++) {\n    list = legend[i];\n    let nameHeight = lineHeight;\n    if (list.nameHeight) {\n      nameHeight = list.nameHeight;\n    }\n    let nameStyle = '';\n    if (nameHeight) {\n      nameStyle =\n        `style=\"height: ${nameHeight}px; ` +\n        `position: relative; ` +\n        `left: -${nameHeight - 5}px;\"`;\n    }\n    if ('name' in list) {\n      labels = `<div ${nameStyle}>` + list.name + `</div>`;\n    }\n    svg = '<svg id=\"_ideogramLegendSvg\" width=\"' + lineHeight + '\">';\n    [labels, svg] = getListItems(labels, svg, list, nameHeight, ideo);\n    svg += '</svg>';\n    content += svg + '<ul>' + labels + '</ul>';\n  }\n\n  var fontFamily = `font-family: ${config.fontFamily};`;\n  var lineHeightCss = `line-height: ${getLineHeight(ideo)}px;`;\n  legendStyle +=\n    `#_ideogramLegend {${fontFamily} ${lineHeightCss}}`;\n\n  var target = d3.select(config.container + ' #_ideogramOuterWrap');\n  target.append('style').html(legendStyle);\n  target.append('div').attr('id', '_ideogramLegend').html(content);\n}\n\nexport {writeLegend};\n","import {d3} from '../lib';\nimport {writeHistogramAnnots} from './histogram';\nimport {writeLegend} from './legend';\n\nfunction parseFriendlyAnnots(friendlyAnnots, rawAnnots) {\n  var i, j, annot, rawAnnot;\n\n  for (i = 0; i < friendlyAnnots.length; i++) {\n    annot = friendlyAnnots[i];\n\n    for (j = 0; j < rawAnnots.length; j++) {\n      if (annot.chr === rawAnnots[j].chr) {\n        rawAnnot = [\n          annot.name,\n          annot.start,\n          annot.stop - annot.start\n        ];\n        if ('color' in annot) rawAnnot.push(annot.color);\n        if ('shape' in annot) rawAnnot.push(annot.shape);\n        rawAnnots[j].annots.push(rawAnnot);\n        break;\n      }\n    }\n  }\n\n  return rawAnnots;\n}\n\nfunction parseFriendlyKeys(friendlyAnnots) {\n  var keys = ['name', 'start', 'length'];\n  if ('color' in friendlyAnnots[0]) {\n    keys.push('color');\n  }\n  if ('shape' in friendlyAnnots[0]) {\n    keys.push('shape');\n  }\n  return keys;\n}\n\n/**\n * Draws annotations defined by user\n */\nfunction drawAnnots(friendlyAnnots, layout, keep=false, isOtherLayout=false) {\n  var keys, chr,\n    rawAnnots = [],\n    ideo = this,\n    chrs = ideo.chromosomes[ideo.config.taxid]; // TODO: multiorganism\n\n  if (\n    'annots' in friendlyAnnots[0] || // When filtering\n    'values' in friendlyAnnots[0] // When drawing cached expression matrices\n  ) {\n    return ideo.drawProcessedAnnots(friendlyAnnots, layout);\n  }\n\n  for (chr in chrs) {\n    rawAnnots.push({chr: chr, annots: []});\n  }\n  rawAnnots = parseFriendlyAnnots(friendlyAnnots, rawAnnots);\n\n  keys = parseFriendlyKeys(friendlyAnnots);\n\n  ideo.rawAnnots = {keys: keys, annots: rawAnnots};\n\n  const processedAnnots = ideo.processAnnotData(ideo.rawAnnots);\n  if (!isOtherLayout) {\n    ideo.annots = processedAnnots;\n  } else {\n    ideo.annotsOther = processedAnnots;\n  }\n\n  ideo.drawProcessedAnnots(processedAnnots, layout, keep);\n}\n\nfunction getShapes(annotHeight) {\n  var triangle, circle, rectangle, r;\n\n  triangle =\n    'm0,0 l -' + annotHeight + ' ' + (2 * annotHeight) +\n    ' l ' + (2 * annotHeight) + ' 0 z';\n\n  // From http://stackoverflow.com/a/10477334, with a minor change (\"m -r, r\")\n  // Circles are supported natively via <circle>, but having it as a path\n  // simplifies handling triangles, circles and other shapes in the same\n  // D3 call\n  r = annotHeight;\n  circle =\n    'm -' + r + ', ' + r +\n    'a ' + r + ',' + r + ' 0 1,0 ' + (r * 2) + ',0' +\n    'a ' + r + ',' + r + ' 0 1,0 -' + (r * 2) + ',0';\n\n  rectangle =\n    'm0,0 l 0 ' + (2 * annotHeight) +\n    'l ' + annotHeight + ' 0' +\n    'l 0 -' + (2 * annotHeight) + 'z';\n\n  return {triangle: triangle, circle: circle, rectangle: rectangle};\n}\n\nfunction getChrAnnotNodes(filledAnnots, ideo) {\n  return d3.selectAll(ideo.selector + ' .chromosome')\n    .data(filledAnnots)\n    .selectAll('path.annot')\n    .data(function(d) {\n      return d.annots;\n    })\n    .enter();\n}\n\nfunction determineShape(d, shapes) {\n  if (!d.shape || d.shape === 'triangle') {\n    return shapes.triangle;\n  } else if (d.shape === 'circle') {\n    return shapes.circle;\n  } else if (d.shape === 'rectangle') {\n    return shapes.rectangle;\n  } else {\n    return d.shape;\n  }\n}\n\nfunction writeTrackAnnots(chrAnnot, ideo) {\n  var shapes,\n    annotHeight = ideo.config.annotationHeight;\n\n  shapes = getShapes(annotHeight);\n\n  chrAnnot.append('g')\n    .attr('id', function(d) {return d.domId;})\n    .attr('class', 'annot')\n    .attr('transform', function(d) {\n      var y = ideo.config.chrWidth + (d.trackIndex * annotHeight * 2);\n      return 'translate(' + d.px + ',' + y + ')';\n    })\n    .append('path')\n    .attr('d', function(d) {return determineShape(d, shapes);})\n    .attr('fill', function(d) {return d.color;})\n    .on('mouseover', function(event, d) {ideo.showAnnotTooltip(d, this);})\n    .on('mouseout', function() {ideo.startHideAnnotTooltipTimeout();})\n    .on('click', function(event, d) {ideo.onClickAnnot(d);});\n}\n\n/**\n * Overlaid annotations appear directly on chromosomes\n */\nfunction writeOverlayAnnots(chrAnnot, ideo) {\n  chrAnnot.append('polygon')\n    .attr('id', function(d) {return d.id;})\n    .attr('class', 'annot')\n    .attr('points', function(d) {\n      var x1, x2,\n        chrWidth = ideo.config.chrWidth;\n\n      if (d.stopPx - d.startPx > 1) {\n        x1 = d.startPx;\n        x2 = d.stopPx;\n      } else {\n        x1 = d.px - 0.5;\n        x2 = d.px + 0.5;\n      }\n\n      return (\n        x1 + ',' + chrWidth + ' ' + x2 + ',' + chrWidth + ' ' +\n        x2 + ',0 ' + x1 + ',0'\n      );\n    })\n    .attr('fill', function(d) {return d.color;})\n    .on('mouseover', function(event, d) {ideo.showAnnotTooltip(d, this);})\n    .on('mouseout', function() {ideo.startHideAnnotTooltipTimeout();});\n}\n\nfunction warnIfTooManyAnnots(layout, annots) {\n  var i, numAnnots;\n\n  if (!/heatmap/.test(layout) && layout !== 'histogram') {\n    numAnnots = 0;\n    for (i = 0; i < annots.length; i++) {\n      numAnnots += annots[i].annots.length;\n    }\n    if (numAnnots > 2000) {\n      console.warn(\n        'Rendering more than 2000 annotations in Ideogram?\\n' +\n        'Try setting \"annotationsLayout\" to \"heatmap\" or \"histogram\" in your ' +\n        'Ideogram configuration object for better layout and performance.'\n      );\n    }\n  }\n}\n\nfunction drawAnnotsByLayoutType(layout, annots, ideo) {\n  var filledAnnots, chrAnnot;\n\n  warnIfTooManyAnnots(layout, annots);\n\n  if (layout === 'histogram') annots = ideo.getHistogramBars(annots);\n\n  filledAnnots = ideo.fillAnnots(annots);\n\n  chrAnnot = getChrAnnotNodes(filledAnnots, ideo);\n\n  if (layout === 'tracks') {\n    writeTrackAnnots(chrAnnot, ideo);\n  } else if (layout === 'overlay') {\n    writeOverlayAnnots(chrAnnot, ideo);\n  } else if (layout === 'histogram') {\n    writeHistogramAnnots(chrAnnot, ideo);\n  }\n}\n\n/**\n * Draws genome annotations on chromosomes.\n * Annotations can be rendered as either overlaid directly\n * on a chromosome, or along one or more \"tracks\"\n * running parallel to each chromosome.\n */\nfunction drawProcessedAnnots(annots, layout, keep=false) {\n  var ideo = this;\n\n  if (!keep) {\n    d3.selectAll(ideo.selector + ' .annot').remove();\n  }\n\n  if (layout === undefined) layout = 'tracks';\n  if (ideo.config.annotationsLayout) layout = ideo.config.annotationsLayout;\n\n  if ('legend' in ideo.config) writeLegend(ideo);\n\n  if (/heatmap/.test(layout)) {\n    ideo.drawHeatmaps(annots);\n    return;\n  }\n\n  drawAnnotsByLayoutType(layout, annots, ideo);\n  if (ideo.onDrawAnnotsCallback) ideo.onDrawAnnotsCallback();\n}\n\nexport {drawAnnots, drawProcessedAnnots, getShapes};\n","import {d3} from '../lib';\n\nexport function writeSyntenicRegion(syntenies, regionID, ideo) {\n  return syntenies.append('g')\n    .attr('class', 'syntenicRegion')\n    .attr('id', regionID)\n    .on('click', function() {\n      var activeRegion = this;\n      var others = d3.selectAll(ideo.selector + ' .syntenicRegion')\n        .filter(function() {return (this !== activeRegion);});\n\n      others.classed('hidden', !others.classed('hidden'));\n    })\n    .on('mouseover', function() {\n      var activeRegion = this;\n      d3.selectAll(ideo.selector + ' .syntenicRegion')\n        .filter(function() {return (this !== activeRegion);})\n        .classed('ghost', true);\n    })\n    .on('mouseout', function() {\n      d3.selectAll(ideo.selector + ' .syntenicRegion')\n        .classed('ghost', false);\n    });\n}\n\nexport function writeSyntenicRegionPolygons(\n  syntenicRegion, x1, x2, r1, r2, regions\n) {\n  var color, opacity;\n\n  color = ('color' in regions) ? regions.color : '#CFC';\n  opacity = ('opacity' in regions) ? regions.opacity : 1;\n\n  syntenicRegion.append('polygon')\n    .attr('points',\n      x1 + ', ' + r1.startPx + ' ' +\n      x1 + ', ' + r1.stopPx + ' ' +\n      x2 + ', ' + r2.stopPx + ' ' +\n      x2 + ', ' + r2.startPx\n    )\n    .style('fill', color)\n    .style('fill-opacity', opacity);\n}\n\nexport function writeSyntenicRegionPolygonsHorizontal(\n  syntenicRegion, y1, y2, r1, r2, regions\n) {\n  var color, opacity;\n\n  color = ('color' in regions) ? regions.color : '#CFC';\n  opacity = ('opacity' in regions) ? regions.opacity : 1;\n\n  syntenicRegion.append('polygon')\n    .attr('points',\n      (r1.startPx - 15) + ', ' + y1 + ' ' +\n      (r1.stopPx - 15) + ', ' + y1 + ' ' +\n      (r2.stopPx - 15) + ', ' + y2 + ' ' +\n      (r2.startPx - 15) + ', ' + y2\n    )\n    .style('fill', color)\n    .style('fill-opacity', opacity);\n}\n\nexport function getRegionsR1AndR2(regions, ideo, xOffset = null) {\n  var r1, r2,\n    r1Offset, r2Offset;\n\n  r1 = regions.r1;\n  r2 = regions.r2;\n\n  if (typeof r1.chr === 'string') {\n    const taxids = ideo.config.taxids;\n    if (ideo.config.multiorganism) {\n      r1.chr = ideo.chromosomes[taxids[0]][r1.chr];\n      r2.chr = ideo.chromosomes[taxids[1]][r2.chr];\n    } else {\n      r1.chr = ideo.chromosomes[taxids[0]][r1.chr];\n      r2.chr = ideo.chromosomes[taxids[0]][r2.chr];\n    }\n  }\n\n  var r1ChrDom = document.querySelector('#' + r1.chr.id + '-chromosome-set');\n  var r1GenomeHorizontalXOffset = r1ChrDom.getCTM().e;\n  var r1GenomeVerticalXOffset = r1ChrDom.getCTM().f;\n  var r2ChrDom = document.querySelector('#' + r2.chr.id + '-chromosome-set');\n  // var r2GenomeOffset = r2ChrDom.getBoundingClientRect().top;\n  var r2GenomeHorizontalXOffset = r2ChrDom.getCTM().e;\n  var r2GenomeVerticalXOffset = r2ChrDom.getCTM().f;\n\n  if (xOffset === null) {\n    if (ideo.config.orientation === 'vertical') {\n      // When vertical collinear\n      // http://localhost:8080/examples/vanilla/compare-whole-genomes?chromosome-scale=absolute&orientation=vertical\n      r1Offset = r1GenomeVerticalXOffset - 12;\n      r2Offset = r2GenomeVerticalXOffset - 12;\n    } else {\n      // When horizontal collinear, e.g.\n      // http://localhost:8080/examples/vanilla/compare-whole-genomes?chromosome-scale=absolute&orientation=horizontal\n      r1Offset = r1GenomeHorizontalXOffset;\n      r2Offset = r2GenomeHorizontalXOffset;\n    }\n  } else {\n    // When horizontal parallel\n    r1Offset = xOffset;\n    r2Offset = xOffset;\n  }\n\n  r1.startPx = ideo.convertBpToPx(r1.chr, r1.start) + r1Offset;\n  r1.stopPx = ideo.convertBpToPx(r1.chr, r1.stop) + r1Offset;\n  r2.startPx = ideo.convertBpToPx(r2.chr, r2.start) + r2Offset;\n  r2.stopPx = ideo.convertBpToPx(r2.chr, r2.stop) + r2Offset;\n\n  return [r1, r2];\n}\n","import {d3} from '../lib';\nimport {\n  getRegionsR1AndR2, writeSyntenicRegionPolygons, writeSyntenicRegion\n} from './synteny-lib';\n\nfunction writeSyntenicRegionLines(syntenicRegion, x1, x2, r1, r2) {\n  syntenicRegion.append('line')\n    .attr('class', 'syntenyBorder')\n    .attr('x1', x1)\n    .attr('x2', x2)\n    .attr('y1', r1.startPx)\n    .attr('y2', r2.startPx);\n\n  syntenicRegion.append('line')\n    .attr('class', 'syntenyBorder')\n    .attr('x1', x1)\n    .attr('x2', x2)\n    .attr('y1', r1.stopPx)\n    .attr('y2', r2.stopPx);\n}\n\nfunction writeSyntenicRegions(syntenicRegions, syntenies, ideo) {\n  var i, regions, r1, r2, regionID, syntenicRegion, chrWidth, x1, x2;\n\n  for (i = 0; i < syntenicRegions.length; i++) {\n    regions = syntenicRegions[i];\n\n    [r1, r2] = getRegionsR1AndR2(regions, ideo);\n\n    regionID = (\n      r1.chr.id + '_' + r1.start + '_' + r1.stop + '_' +\n      '__' +\n      r2.chr.id + '_' + r2.start + '_' + r2.stop\n    );\n\n    syntenicRegion = writeSyntenicRegion(syntenies, regionID, ideo);\n\n    chrWidth = ideo.config.chrWidth;\n    x1 = chrWidth + 51;\n    x2 = chrWidth + 245; // Genomes are spaced ~200 pixels apart\n\n    writeSyntenicRegionPolygons(syntenicRegion, x1, x2, r1, r2, regions);\n    writeSyntenicRegionLines(syntenicRegion, x1, x2, r1, r2);\n  }\n}\n\nfunction reportPerformance(t0, ideo) {\n  var t1 = new Date().getTime();\n  if (ideo.config.debug) {\n    console.log('Time in drawSyntenicRegions: ' + (t1 - t0) + ' ms');\n  }\n}\n\n/**\n * Draws a trapezoid connecting a genomic range on\n * one chromosome to a genomic range on another chromosome;\n * a syntenic region.\n */\nfunction drawSyntenyCollinear(syntenicRegions, ideo) {\n  var syntenies,\n    t0 = new Date().getTime();\n\n  syntenies = d3.select(ideo.selector)\n    .insert('g', ':first-child')\n    .attr('class', 'synteny');\n\n  writeSyntenicRegions(syntenicRegions, syntenies, ideo);\n\n  reportPerformance(t0, ideo);\n}\n\nexport {drawSyntenyCollinear};\n","import {d3} from '../lib';\nimport {\n  getRegionsR1AndR2, writeSyntenicRegionPolygonsHorizontal, writeSyntenicRegion\n} from './synteny-lib';\n\nfunction writeSyntenicRegionLines(syntenicRegion, y1, y2, r1, r2) {\n  syntenicRegion.append('line')\n    .attr('class', 'syntenyBorder')\n    .attr('x1', r1.startPx - 15)\n    .attr('x2', r2.startPx - 15)\n    .attr('y1', y1)\n    .attr('y2', y2);\n\n  syntenicRegion.append('line')\n    .attr('class', 'syntenyBorder')\n    .attr('x1', r1.stopPx - 15)\n    .attr('x2', r2.stopPx - 15)\n    .attr('y1', y1)\n    .attr('y2', y2);\n}\n\nfunction writeSyntenicRegions(syntenicRegions, syntenies, ideo) {\n  var i, regions, r1, r2, regionID, syntenicRegion, chrWidth, y1, y2;\n\n  for (i = 0; i < syntenicRegions.length; i++) {\n    regions = syntenicRegions[i];\n\n    [r1, r2] = getRegionsR1AndR2(regions, ideo);\n\n    regionID = (\n      r1.chr.id + '_' + r1.start + '_' + r1.stop + '_' +\n      '__' +\n      r2.chr.id + '_' + r2.start + '_' + r2.stop\n    );\n\n    syntenicRegion = writeSyntenicRegion(syntenies, regionID, ideo);\n\n    chrWidth = ideo.config.chrWidth;\n    y1 = chrWidth + 31;\n    y2 = chrWidth + 191; // Genomes are spaced ~200 pixels apart\n\n    writeSyntenicRegionPolygonsHorizontal(\n      syntenicRegion, y1, y2, r1, r2, regions\n    );\n    writeSyntenicRegionLines(syntenicRegion, y1, y2, r1, r2);\n  }\n}\n\nfunction reportPerformance(t0, ideo) {\n  var t1 = new Date().getTime();\n  if (ideo.config.debug) {\n    console.log('Time in drawSyntenicRegions: ' + (t1 - t0) + ' ms');\n  }\n}\n\n/**\n * Draws a trapezoid connecting a genomic range on\n * one chromosome to a genomic range on another chromosome;\n * a syntenic region.\n */\nfunction drawSyntenyCollinearHorizontal(syntenicRegions, ideo) {\n  var syntenies,\n    t0 = new Date().getTime();\n\n  syntenies = d3.select(ideo.selector)\n    .insert('g', ':first-child')\n    .attr('class', 'synteny');\n\n  writeSyntenicRegions(syntenicRegions, syntenies, ideo);\n\n  reportPerformance(t0, ideo);\n}\n\nexport {drawSyntenyCollinearHorizontal};\n","import {d3} from '../lib';\nimport {drawSyntenyCollinear} from './synteny-collinear';\nimport {drawSyntenyCollinearHorizontal} from './synteny-collinear-horizontal';\nimport {\n  getRegionsR1AndR2, writeSyntenicRegionPolygons, writeSyntenicRegion\n} from './synteny-lib';\n\nfunction writeSyntenicRegionLines(syntenicRegion, x1, x2, r1, r2, regions) {\n\n  var stroke, width;\n  if (\n    Math.abs(r1.startPx - r1.startPx) < 2 &&\n    Math.abs(r1.stopPx - r1.stopPx) < 2\n  ) {\n    stroke = regions.color;\n    width = regions.width;\n  } else {\n    stroke = '';\n    width = '';\n  }\n\n  syntenicRegion.append('line')\n    .attr('class', 'syntenyBorder')\n    .attr('x1', x1)\n    .attr('x2', x2)\n    .attr('y1', r1.startPx)\n    .attr('y2', r2.startPx)\n    .style('stroke', stroke)\n    .style('stroke-width', width);\n\n  syntenicRegion.append('line')\n    .attr('class', 'syntenyBorder')\n    .attr('x1', x1)\n    .attr('x2', x2)\n    .attr('y1', r1.stopPx)\n    .attr('y2', r2.stopPx)\n    .style('stroke', stroke)\n    .style('stroke-width', stroke);\n}\n\nfunction writeSyntenicRegionLabels(syntenicRegion, x1, x2, r1, r2, regionId) {\n  var rangeIds = regionId.split('__').map(d => 'label_' + d);\n  if ('name' in r1) {\n    syntenicRegion.append('text')\n      .attr('id', rangeIds[0])\n      .attr('y', r1.startPx + 3)\n      .text(r1.name);\n    var r1Width =\n      document.querySelector('#' + rangeIds[0]).getBoundingClientRect().width;\n    d3.select('#' + rangeIds[0]).attr('x', x1 - 15 - r1Width);\n  }\n  if ('name' in r2) {\n    syntenicRegion.append('text')\n      .attr('id', rangeIds[1])\n      .text(r2.name)\n      .attr('x', x2 + 15)\n      .attr('y', r2.startPx + 3)\n      .text(r2.name);\n  }\n}\n\nfunction writeSyntenicRegions(syntenicRegions, syntenies, xOffset, ideo) {\n  var i, regions, r1, r2, regionID, syntenicRegion, chrWidth, x1, x2;\n\n  for (i = 0; i < syntenicRegions.length; i++) {\n    regions = syntenicRegions[i];\n\n    [r1, r2] = getRegionsR1AndR2(regions, ideo, xOffset);\n\n    regionID = (\n      r1.chr.id + '_' + r1.start + '_' + r1.stop + '_' +\n      '__' +\n      r2.chr.id + '_' + r2.start + '_' + r2.stop\n    );\n\n    syntenicRegion = writeSyntenicRegion(syntenies, regionID, ideo);\n\n    chrWidth = ideo.config.chrWidth;\n    x1 = ideo._layout.getChromosomeSetYTranslate(0);\n    x2 = ideo._layout.getChromosomeSetYTranslate(1) - chrWidth;\n\n    writeSyntenicRegionPolygons(syntenicRegion, x1, x2, r1, r2, regions);\n    writeSyntenicRegionLines(syntenicRegion, x1, x2, r1, r2, regions);\n    writeSyntenicRegionLabels(syntenicRegion, x1, x2, r1, r2, regionID);\n  }\n}\n\nfunction reportPerformance(t0, ideo) {\n  var t1 = new Date().getTime();\n  if (ideo.config.debug) {\n    console.log('Time in drawSyntenicRegions: ' + (t1 - t0) + ' ms');\n  }\n}\n\n/**\n * Draws a trapezoid connecting a genomic range on\n * one chromosome to a genomic range on another chromosome;\n * a syntenic region.\n */\nfunction drawSynteny(syntenicRegions) {\n  var syntenies, xOffset,\n    t0 = new Date().getTime(),\n    ideo = this,\n    config = ideo.config;\n\n  // Make synteny / orthologs readable from client apps\n  ideo.syntenicRegions = syntenicRegions;\n\n  if (\n    config.multiorganism &&\n    config.geometry === 'collinear'\n  ) {\n    if (config.orientation === 'vertical') {\n      return drawSyntenyCollinear(syntenicRegions, ideo);\n    } else {\n      return drawSyntenyCollinearHorizontal(syntenicRegions, ideo);\n    }\n  }\n\n  syntenies = d3.select(ideo.selector)\n    .insert('g', ':first-child')\n    .attr('class', 'synteny');\n\n  xOffset = ideo._layout.margin.left;\n\n  writeSyntenicRegions(syntenicRegions, syntenies, xOffset, ideo);\n\n  reportPerformance(t0, ideo);\n}\n\nexport {drawSynteny};\n","import {d3} from '../lib';\nimport collinearizeChromosomes from '../collinear';\n\n/**\n * Reset displayed tracks to those originally displayed\n */\nfunction restoreDefaultTracks() {\n  var ideo = this;\n  ideo.config.numAnnotTracks = ideo.config.annotationsNumTracks;\n  d3.selectAll(ideo.selector + ' .annot').remove();\n  ideo.drawAnnots(ideo.processAnnotData(ideo.rawAnnots));\n}\n\nfunction getDisplayedRawAnnotsByChr(annotsByChr, trackIndexes) {\n  var annot, displayedRawAnnotsByChr, annots, i, displayedAnnots, j,\n    trackIndex;\n\n  displayedRawAnnotsByChr = [];\n\n  // Filter displayed tracks by selected track indexes\n  for (i = 0; i < annotsByChr.length; i++) {\n    annots = annotsByChr[i];\n    displayedAnnots = [];\n    for (j = 0; j < annots.annots.length; j++) {\n      annot = annots.annots[j].slice(); // copy array by value\n      trackIndex = annot[3] + 1;\n      if (trackIndexes.includes(trackIndex)) {\n        annot[3] = trackIndexes.indexOf(trackIndex);\n        displayedAnnots.push(annot);\n      }\n    }\n    displayedRawAnnotsByChr.push({chr: annots.chr, annots: displayedAnnots});\n  }\n\n  return displayedRawAnnotsByChr;\n}\n\n/**\n * Adds or removes tracks from the displayed list of tracks.\n * Only works when raw annotations are dense.\n *\n * @param trackIndexes Array of indexes of tracks to display\n */\nfunction updateDisplayedTracks(trackIndexes) {\n  var displayedRawAnnotsByChr, displayedAnnots, rawAnnots,\n    ideo = this,\n    annotsByChr = ideo.rawAnnots.annots;\n\n  ideo.config.numAnnotTracks = trackIndexes.length;\n\n  displayedRawAnnotsByChr =\n    getDisplayedRawAnnotsByChr(annotsByChr, trackIndexes);\n  rawAnnots = {keys: ideo.rawAnnots.keys, annots: displayedRawAnnotsByChr};\n\n  if (ideo.config.geometry === 'collinear') {\n    collinearizeChromosomes(ideo);\n  }\n\n  displayedAnnots = ideo.processAnnotData(rawAnnots);\n\n  d3.selectAll(ideo.selector + ' .annot').remove();\n  ideo.displayedTrackIndexes = trackIndexes;\n  ideo.drawAnnots(displayedAnnots);\n\n  return displayedAnnots;\n}\n\nfunction getSetAnnotsByChr(annotsByChr, ideo) {\n  var i, j, annots, annot, setAnnots, trackIndexOriginal, numAvailTracks,\n    setAnnotsByChr = [];\n\n  numAvailTracks = 1;\n\n  for (i = 0; i < annotsByChr.length; i++) {\n    annots = annotsByChr[i];\n    setAnnots = [];\n    for (j = 0; j < annots.annots.length; j++) {\n      annot = annots.annots[j].slice();\n      trackIndexOriginal = annot[3];\n      if (trackIndexOriginal + 1 > numAvailTracks) {\n        numAvailTracks = trackIndexOriginal + 1;\n      }\n      annot.splice(4, 0, trackIndexOriginal);\n      setAnnots.push(annot);\n    }\n    setAnnotsByChr.push({chr: annots.chr, annots: setAnnots});\n  }\n\n  ideo.numAvailTracks = numAvailTracks;\n\n  return setAnnotsByChr;\n}\n\nfunction setOriginalTrackIndexes(rawAnnots) {\n  var keys, annotsByChr, setAnnotsByChr,\n    ideo = this;\n\n  keys = rawAnnots.keys;\n\n  // If this method is unnecessary, pass through\n  if (\n    keys.length < 4 ||\n    keys[3] !== 'trackIndex' ||\n    keys[4] === 'trackIndexOriginal'\n  ) {\n    return rawAnnots;\n  }\n\n  annotsByChr = rawAnnots.annots;\n  setAnnotsByChr = getSetAnnotsByChr(annotsByChr, ideo);\n\n  keys.splice(4, 0, 'trackIndexOriginal');\n  rawAnnots = {keys: keys, annots: setAnnotsByChr};\n  if (ideo.rawAnnots.metadata) rawAnnots.metadata = ideo.rawAnnots.metadata;\n\n  return rawAnnots;\n}\n\nexport {restoreDefaultTracks, setOriginalTrackIndexes, updateDisplayedTracks};\n","import {add2dAnnotsForChr} from './heatmap-2d';\nimport {setAnnotRanks} from './annotations';\n\n// Default colors for tracks of annotations\nvar colorMap = [\n  ['F00'], // If there is 1 track, then color it red.\n  ['F00', '88F'], // If 2 tracks, color one red and one light blue.\n  ['F00', 'CCC', '88F'], // If 3, color one red, one grey, one light blue.\n  ['F00', 'FA0', '0AF', '88F'], // And so on.\n  ['F00', 'FA0', 'CCC', '0AF', '88F'],\n  ['F00', 'FA0', '875', '578', '0AF', '88F'],\n  ['F00', 'FA0', '875', 'CCC', '578', '0AF', '88F'],\n  ['F00', 'FA0', '7A0', '875', '0A7', '578', '0AF', '88F'],\n  ['F00', 'FA0', '7A0', '875', 'CCC', '0A7', '578', '0AF', '88F'],\n  ['F00', 'FA0', '7A0', '875', '552', '255', '0A7', '578', '0AF', '88F']\n];\n\n/**\n * Ensure annotation containers are ordered by chromosome.\n */\nfunction orderAnnotContainers(annots, ideo) {\n  var unorderedAnnots, i, j, annot, chr, chrs;\n\n  unorderedAnnots = annots;\n  annots = [];\n  chrs = ideo.chromosomesArray;\n  for (i = 0; i < chrs.length; i++) {\n    chr = chrs[i].name;\n    for (j = 0; j < unorderedAnnots.length; j++) {\n      annot = unorderedAnnots[j];\n      if (annot.chr === chr) {\n        annots.push(annot);\n      }\n    }\n  }\n\n  return annots;\n}\n\n/**\n * Add client annotations, as in annotations-tracks.html\n */\nfunction addClientAnnot(annots, annot, ra, m, ideo) {\n  var annotTrack;\n\n  annot.trackIndex = ra[3];\n  annotTrack = ideo.config.annotationTracks[annot.trackIndex];\n  if (annotTrack.color) {\n    annot.color = annotTrack.color;\n  }\n  if (annotTrack.shape) {\n    annot.shape = annotTrack.shape;\n  }\n\n  annots[m].annots.push(annot);\n\n  return annots;\n}\n\n/**\n * Add sparse server annotations, as in annotations-track-filters.html\n */\nfunction addSparseServerAnnot(annot, ra, omittedAnnots, annots, m, ideo) {\n  var colors = colorMap[ideo.numAvailTracks - 1];\n\n  annot.trackIndex = ra[3];\n  annot.trackIndexOriginal = ra[4];\n  annot.color = '#' + colors[annot.trackIndexOriginal];\n\n  // Catch annots that will be omitted from display\n  if (annot.trackIndex > ideo.config.numTracks - 1) {\n    if (annot.trackIndex in omittedAnnots) {\n      omittedAnnots[annot.trackIndex].push(annot);\n    } else {\n      omittedAnnots[annot.trackIndex] = [annot];\n    }\n    return [annots, omittedAnnots];\n  }\n  annots[m].annots.push(annot);\n\n  return [annots, omittedAnnots];\n}\n\n/**\n * Basic client annotations, as in annotations-basic.html\n * and annotations-external.html\n */\nfunction addBasicClientAnnot(annots, annot, m, ideo) {\n  annot.trackIndex = 0;\n  if (!annot.color) {\n    annot.color = ideo.config.annotationsColor;\n  }\n  if (!annot.shape) {\n    annot.shape = 'triangle';\n  }\n  annots[m].annots.push(annot);\n\n  return annots;\n}\n\nfunction addAnnot(annot, keys, ra, omittedAnnots, annots, m, ideo) {\n\n  if (ideo.config.annotationTracks) {\n    annots = addClientAnnot(annots, annot, ra, m, ideo);\n  } else if (keys[3] === 'trackIndex' && ideo.numAvailTracks !== 1) {\n    [annots, omittedAnnots] =\n      addSparseServerAnnot(annot, ra, omittedAnnots, annots, m, ideo);\n  // } else if (\n  //   keys.length > 3 &&\n  //   keys[3] in {trackIndex: 1, color: 1, shape: 1} === false &&\n  //   keys[4] === 'trackIndexOriginal'\n  // ) {\n  //   annots = addDenseServerAnnot(keys, annots, annot, m);\n  } else {\n    annots = addBasicClientAnnot(annots, annot, m, ideo);\n  }\n\n  return [annots, omittedAnnots];\n}\n\nfunction getAnnotDomId(chrIndex, annotIndex) {\n  return '_c' + chrIndex + '_a' + annotIndex;\n}\n\nfunction addAnnotsForChr(annots, omittedAnnots, annotsByChr, chrModel,\n  m, keys, ideo) {\n  var j, k, annot, ra;\n\n  // Assign DOM ID if annots are rendered as individual DOM elements\n  const shouldAssignDomId = (\n    !ideo.config.annotationsLayout ||\n    ideo.config.annotationsLayout === 'tracks'\n  );\n\n  for (j = 0; j < annotsByChr.annots.length; j++) {\n    ra = annotsByChr.annots[j];\n    annot = {};\n\n    for (k = 0; k < keys.length; k++) {\n      annot[keys[k]] = ra[k];\n    }\n\n    annot.stop = annot.start + annot.length;\n\n    annot.chr = annotsByChr.chr;\n    annot.chrIndex = m;\n    annot.startPx = ideo.convertBpToPx(chrModel, annot.start);\n    annot.stopPx = ideo.convertBpToPx(chrModel, annot.stop);\n    annot.px = Math.round((annot.startPx + annot.stopPx) / 2);\n    if (shouldAssignDomId) annot.domId = getAnnotDomId(m, j);\n\n    [annots, omittedAnnots] =\n      addAnnot(annot, keys, ra, omittedAnnots, annots, m, ideo);\n  }\n\n  if (shouldAssignDomId) {\n    if (ideo.annotSortFunction) {\n      annots[m].annots = setAnnotRanks(annots[m].annots, ideo);\n      annots[m].annots.sort((a, b) => {\n        // Reverse-sort, so first annots are drawn last, and thus at top layer\n        return -ideo.annotSortFunction(a, b);\n      });\n    } else {\n      // Sort by genomic position, in ascending order\n      annots[m].annots.sort((a, b) => a[1] - b[1]);\n    }\n\n    for (j = 0; j < annots[m].annots.length; j++) {\n      annots[m].annots[j].domId = getAnnotDomId(m, j);\n    }\n  }\n\n  return [annots, omittedAnnots];\n}\n\nfunction warnOfUndefinedChromosome(annotsByChr) {\n  console.warn(\n    'Chromosome \"' + annotsByChr.chr + '\" undefined in ideogram; ' +\n    annotsByChr.annots.length + ' annotations not shown'\n  );\n}\n\nfunction addAnnots(rawAnnots, keys, ideo) {\n  var m, i, annotsByChr, chrModel,\n    annots = [],\n    omittedAnnots = {};\n\n  m = -1;\n  for (i = 0; i < rawAnnots.length; i++) {\n    annotsByChr = rawAnnots[i];\n    chrModel = ideo.chromosomes[ideo.config.taxid][annotsByChr.chr];\n\n    if (typeof chrModel === 'undefined') {\n      warnOfUndefinedChromosome(annotsByChr);\n      continue;\n    }\n\n    m++;\n    annots.push({chr: annotsByChr.chr, annots: []});\n\n    if (ideo.config.annotationsLayout !== 'heatmap-2d') {\n      [annots, omittedAnnots] =\n        addAnnotsForChr(annots, omittedAnnots, annotsByChr, chrModel, m,\n          keys, ideo);\n    } else {\n      [annots, omittedAnnots] =\n        add2dAnnotsForChr(annots, omittedAnnots, annotsByChr, chrModel, m,\n          keys, ideo);\n    }\n  }\n  return [annots, omittedAnnots];\n}\n\nfunction sendTrackAndAnnotWarnings(omittedAnnots, ideo) {\n  var numOmittedTracks,\n    layout = ideo.config.annotationsLayout,\n    numTracks = ideo.config.numAnnotTracks;\n\n  if (!/heatmap/.test(layout) && numTracks > 10) {\n    console.error(\n      'Ideogram only displays up to 10 tracks at a time.  ' +\n      'You specified ' + numTracks + ' tracks.  ' +\n      'Perhaps consider a different way to visualize your data.'\n    );\n  }\n\n  numOmittedTracks = Object.keys(omittedAnnots).length;\n  if (numOmittedTracks) {\n    console.warn(\n      'Ideogram configuration specified ' + numTracks + ' tracks, ' +\n      'but loaded annotations contain ' + numOmittedTracks + ' ' +\n      'extra tracks.'\n    );\n  }\n}\n\n/**\n * Proccesses genome annotation data.\n *\n * This method converts raw annotation data from server, which is structured as\n * an array of arrays, into a more verbose data structure consisting of an\n * array of objects.  It also adds pixel offset information.\n */\nfunction processAnnotData(rawAnnots) {\n  var keys, annots, omittedAnnots,\n    ideo = this;\n\n  keys = rawAnnots.keys;\n  rawAnnots = rawAnnots.annots;\n\n  [annots, omittedAnnots] = addAnnots(rawAnnots, keys, ideo);\n  annots = orderAnnotContainers(annots, ideo);\n\n  sendTrackAndAnnotWarnings(omittedAnnots, ideo);\n\n  return annots;\n}\n\nexport {processAnnotData, getAnnotDomId};\n","/**\n * @fileoverview Parse raw Ideogram.js annotations from an expression matrix.\n * This module handles dense gene expression matrixes.\n * In gene expression expressions, rows are genes and columns are cells.\n */\n\nexport class ExpressionMatrixParser {\n\n  /**\n   * @param {String} matrix Tab-delimited gene expression matrix\n   * @param {Object} coordinates Coordinates [chr, start, length] by gene name\n   * @param {Object} ideo Ideogram object\n   */\n  constructor(matrix, ideo) {\n    this.matrix = matrix;\n    this.ideo = ideo;\n  }\n\n  /**\n   * Initialize rawAnnots by fetching genomic coordinates, then merging them\n   * with the gene expression matrix supplied in constructor.\n   */\n  setRawAnnots() {\n    var parser, ideo, matrix;\n    parser = this;\n    ideo = this.ideo;\n    matrix = this.matrix;\n\n    return new Promise(function(resolve) {\n      parser.rawAnnots = parser.fetchCoordinates(ideo)\n        .then(function(coordinates) {\n          parser.coordinates = coordinates;\n          resolve(parser.parseExpressionMatrix(matrix, ideo));\n        });\n    });\n  }\n\n  /**\n   * Get chromosome, start and stop coordinates from genome annotation file\n   *\n   * TODO: Support non-human organisms\n   */\n  fetchCoordinates(ideo) {\n    var coordinates = {};\n\n    if (ideo.config.organism === 'human') {\n      var ensemblData =\n        ideo.config.dataDir +\n        '../../annotations/Homo_sapiens,_Ensembl_80.tsv';\n\n      return new Promise(function(resolve) {\n        ideo.fetch(ensemblData, 'text').then(function(data) {\n          // eslint-disable-next-line no-unused-vars\n          var tsvLines, i, start, stop, gene, chr, length;\n\n          tsvLines = data.split(/\\r\\n|\\n/).slice(1);\n          for (i = 0; i < tsvLines.length; i++) {\n            [start, stop, gene, , chr] = tsvLines[i].split(/\\s/g);\n            start = parseInt(start);\n            stop = parseInt(stop);\n            length = stop - start;\n            coordinates[gene] = [chr, start, length];\n          }\n          resolve(coordinates);\n        });\n      });\n    } else {\n      throw Error('Expression matrix parsing is only supported for human');\n    }\n  }\n\n  /**\n   * Parses an annotation from a tab-separated line of a matrix file\n   */\n  parseAnnotFromTsvLine(tsvLine, chrs) {\n    var annot, chrIndex, chr, start, gene, expressions,\n      columns = tsvLine.split(/\\s/g);\n\n    gene = columns[0];\n    if (gene in this.coordinates === false) return [null, null];\n\n    expressions = columns.slice(1).map(d => parseFloat(d));\n    [chr, start, length] = this.coordinates[gene];\n\n    chrIndex = chrs.indexOf(chr);\n    if (chrIndex === -1) return [null, null];\n\n    annot = [gene, start, length];\n    annot = annot.concat(expressions);\n\n    return [chrIndex, annot];\n  }\n\n  /**\n  * Parses a gene expression matrix file, returns raw annotations\n  */\n  parseExpressionMatrix(matrix, ideo) {\n    var i, chrs, rawAnnots, cells, line, chrIndex, annot, keys,\n      annots = [],\n      tsvLines = matrix.split(/\\r\\n|\\n/);\n\n    chrs = Object.keys(ideo.chromosomes[ideo.config.taxid]);\n    for (i = 0; i < chrs.length; i++) {\n      annots.push({chr: chrs[i], annots: []});\n    }\n\n    for (i = 1; i < tsvLines.length; i++) {\n      line = tsvLines[i];\n      [chrIndex, annot] = this.parseAnnotFromTsvLine(line, chrs);\n      if (chrIndex !== null) annots[chrIndex].annots.push(annot);\n    }\n\n    cells = tsvLines[0].split(/\\s/g);\n    keys = ['name', 'start', 'length'].concat(cells);\n    rawAnnots = {keys: keys, annots: annots};\n\n    return rawAnnots;\n  }\n\n}\n","function downloadAnnotations() {\n\n  const ideo = this;\n  const annots = {};\n\n  ideo.annots.forEach(chrAnnots => {\n    chrAnnots.annots.forEach(annot => {\n      const desc = ideo.annotDescriptions.annots[annot.name];\n\n      annots[annot.name] = [\n        annot.name, desc.ensemblId,\n        annot.chr, annot.start, annot.stop, annot.length,\n        desc.type\n      ];\n    });\n  });\n\n  const header = [\n    '# Gene name', 'Ensembl ID', 'Chromosome', 'Start', 'Stop', 'Length', 'Type'\n  ];\n  const rows = [header].concat(Object.values(annots));\n  const annotsTsv =\n    ideo.annotDescriptions.headers + '\\n#\\n' +\n    rows.map(row => row.join('\\t')).join('\\n');\n\n  const annotsHref =\n    'data:text/plain;charset=utf-8,' + encodeURIComponent(annotsTsv);\n\n  var evt = new MouseEvent('click', {\n    view: window,\n    bubbles: false,\n    cancelable: true\n  });\n\n  var a = document.createElement('a');\n  a.setAttribute('download', 'ideogram.tsv');\n  a.setAttribute('href', annotsHref);\n  a.setAttribute('target', '_blank');\n\n  // Enables easy testing\n  a.setAttribute('id', '_ideo-undisplayed-dl-annots-link');\n  a.setAttribute('style', 'display: none;');\n  document.body.appendChild(a);\n\n  a.dispatchEvent(evt);\n}\n\nexport {downloadAnnotations};\n","/**\n * @fileoverview Methods for ideogram annotations.\n * Annotations are graphical objects that represent features of interest\n * located on the chromosomes, e.g. genes or variations.  They can\n * appear beside a chromosome, overlaid on top of it, or between multiple\n * chromosomes.\n */\n\nimport {BedParser} from '../parsers/bed-parser';\nimport {TsvParser} from '../parsers/tsv-parser';\nimport {drawHeatmaps, deserializeAnnotsForHeatmap} from './heatmap';\nimport {inflateThresholds} from './heatmap-lib';\nimport {inflateHeatmaps} from './heatmap-collinear';\nimport {\n  onLoadAnnots, onDrawAnnots, startHideAnnotTooltipTimeout,\n  onWillShowAnnotTooltip, onDidShowAnnotTooltip, showAnnotTooltip, onClickAnnot\n} from './events';\n\nimport {\n  addAnnotLabel, removeAnnotLabel, fillAnnotLabels, clearAnnotLabels\n  // fadeOutAnnotLabels\n} from './labels';\n\nimport {drawAnnots, drawProcessedAnnots} from './draw';\nimport {getHistogramBars} from './histogram';\nimport {drawSynteny} from './synteny';\nimport {\n  restoreDefaultTracks, setOriginalTrackIndexes, updateDisplayedTracks\n} from './filter';\nimport {processAnnotData} from './process';\nimport {ExpressionMatrixParser} from '../parsers/expression-matrix-parser';\nimport {downloadAnnotations} from './download';\n\nfunction initNumTracksAndBarWidth(ideo, config) {\n\n  if (config.annotationTracks) {\n    ideo.config.numAnnotTracks = config.annotationTracks.length;\n  } else if (config.annotationsNumTracks) {\n    ideo.config.numAnnotTracks = config.annotationsNumTracks;\n  } else {\n    ideo.config.numAnnotTracks = 1;\n  }\n  ideo.config.annotTracksHeight =\n    config.annotationHeight * config.numAnnotTracks;\n\n  if (typeof config.barWidth === 'undefined') {\n    ideo.config.barWidth = 3;\n  }\n}\n\nfunction initTooltip(ideo, config) {\n  if (config.showAnnotTooltip !== false) {\n    ideo.config.showAnnotTooltip = true;\n  }\n\n  if (config.onWillShowAnnotTooltip) {\n    ideo.onWillShowAnnotTooltipCallback = config.onWillShowAnnotTooltip;\n  }\n\n  if (config.onDidShowAnnotTooltip) {\n    ideo.onDidShowAnnotTooltipCallback = config.onDidShowAnnotTooltip;\n  }\n}\n\nfunction initAnnotLabel(ideo, config) {\n  if (config.addAnnotLabel !== false) {\n    ideo.config.addAnnotLabel = true;\n  }\n\n  if (config.onWillAddAnnotLabel) {\n    ideo.onWillAddAnnotLabelCallback = config.onWillAddAnnotLabel;\n  }\n}\n\nfunction initAnnotHeight(ideo) {\n  var config = ideo.config;\n  var annotHeight;\n\n  if (!config.annotationHeight) {\n    if (config.annotationsLayout === 'heatmap') {\n      annotHeight = config.chrWidth - 1;\n    } else {\n      annotHeight = Math.round(config.chrHeight / 100);\n      if (annotHeight < 3) annotHeight = 3;\n    }\n    ideo.config.annotationHeight = annotHeight;\n  }\n}\n\n/**\n * Initializes various annotation settings.  Constructor help function.\n */\nfunction initAnnotSettings() {\n  var ideo = this,\n    config = ideo.config;\n\n  initAnnotHeight(ideo);\n\n  if (\n    config.annotationsPath || config.localAnnotationsPath ||\n    ideo.annots || config.annotations\n  ) {\n    initNumTracksAndBarWidth(ideo, config);\n  } else {\n    ideo.config.annotTracksHeight = 0;\n    ideo.config.numAnnotTracks = 0;\n  }\n\n  if (typeof config.annotationsColor === 'undefined') {\n    ideo.config.annotationsColor = '#F00';\n  }\n\n  if (config.onClickAnnot) {\n    ideo.onClickAnnotCallback = config.onClickAnnot;\n  }\n\n  initTooltip(ideo, config);\n  initAnnotLabel(ideo, config);\n}\n\nfunction validateAnnotsUrl(annotsUrl) {\n  var tmp, extension;\n\n  tmp = annotsUrl.split('?')[0].split('.');\n  extension = tmp[tmp.length - 1];\n\n  if (['bed', 'json', 'tsv'].includes(extension) === false) {\n    extension = extension.toUpperCase();\n    alert(\n      'Ideogram.js only supports BED and Ideogram JSON and TSV ' +\n      'at the moment.  ' +\n      'Sorry, check back soon for ' + extension + ' support!'\n    );\n    return;\n  }\n  return extension;\n}\n\n/** Find redundant chromosomes in raw annotations */\nfunction detectDuplicateChrsInRawAnnots(ideo) {\n  const seen = {};\n  const duplicates = [];\n  const chrs = ideo.rawAnnots.annots.map(annot => annot.chr);\n\n  chrs.forEach((chr) => {\n    if (chr in seen) duplicates.push(chr);\n    seen[chr] = 1;\n  });\n\n  if (duplicates.length > 0) {\n    const message =\n      `Duplicate chromosomes detected.\\n` +\n      `Chromosome list: ${chrs}.  Duplicates: ${duplicates}.\\n` +\n      `To fix this, edit your raw annotations JSON data to remove redundant ` +\n      `chromosomes.`;\n    throw Error(message);\n  }\n}\n\nfunction afterRawAnnots() {\n  var ideo = this,\n    config = ideo.config;\n\n  // Ensure annots are ordered by chromosome\n  ideo.rawAnnots.annots = ideo.rawAnnots.annots.sort(Ideogram.sortChromosomes);\n\n  if (ideo.onLoadAnnotsCallback) {\n    ideo.onLoadAnnotsCallback();\n  }\n\n  if (\n    'heatmapThresholds' in config ||\n    'metadata' in ideo.rawAnnots &&\n    'heatmapThresholds' in ideo.rawAnnots.metadata\n  ) {\n    if (config.annotationsLayout === 'heatmap') {\n      inflateHeatmaps(ideo);\n    } else if (config.annotationsLayout === 'heatmap-2d') {\n      ideo.config.heatmapThresholds = inflateThresholds(ideo);\n    }\n  }\n\n  if (config.heatmaps) {\n    ideo.deserializeAnnotsForHeatmap(ideo.rawAnnots);\n  }\n\n  detectDuplicateChrsInRawAnnots(ideo);\n}\n\n/**\n * Converts list of annotation-by-chromosome objects to list of annot objects\n */\nfunction flattenAnnots() {\n  const ideo = this;\n  return ideo.annots.reduce((accumulator, annots) => {\n    return [...accumulator, ...annots.annots];\n  }, []);\n}\n\n/**\n * Requests annotations URL via HTTP, sets ideo.rawAnnots for downstream\n * processing.\n *\n * @param annotsUrl Absolute or relative URL for native or BED annotations file\n */\nfunction fetchAnnots(annotsUrl) {\n  var extension, is2dHeatmap,\n    ideo = this,\n    config = ideo.config;\n\n  is2dHeatmap = config.annotationsLayout === 'heatmap-2d';\n\n  var extension = validateAnnotsUrl(annotsUrl);\n\n  if (annotsUrl.slice(0, 4) !== 'http' && !is2dHeatmap && extension !== 'tsv') {\n    ideo.fetch(annotsUrl)\n      .then(function(data) {\n        ideo.rawAnnotsResponse = data; // Preserve truly raw response content\n        ideo.rawAnnots = data; // Sometimes gets partially processed\n        ideo.afterRawAnnots();\n      });\n    return;\n  }\n\n  extension = (is2dHeatmap ? '' : extension);\n\n  ideo.fetch(annotsUrl, 'text')\n    .then(function(text) {\n      ideo.rawAnnotsResponse = text;\n      if (is2dHeatmap) {\n        var parser = new ExpressionMatrixParser(text, ideo);\n        parser.setRawAnnots().then(function(d) {\n          ideo.rawAnnots = d;\n          ideo.afterRawAnnots();\n        });\n      } else {\n        if (extension === 'tsv') {\n          ideo.rawAnnots = new TsvParser(text, ideo).rawAnnots;\n        } else if (extension === 'bed') {\n          ideo.rawAnnots = new BedParser(text, ideo).rawAnnots;\n        } else {\n          ideo.rawAnnots = JSON.parse(text);\n        }\n        ideo.afterRawAnnots();\n      }\n    });\n}\n\n/**\n * Fills out annotations data structure such that its top-level list of arrays\n * matches that of this ideogram's chromosomes list in order and number\n * Fixes https://github.com/eweitz/ideogram/issues/66\n */\nfunction fillAnnots(annots) {\n  var filledAnnots, chrs, chrArray, i, chr, annot, chrIndex;\n\n  filledAnnots = [];\n  chrs = [];\n  chrArray = this.chromosomesArray;\n\n  for (i = 0; i < chrArray.length; i++) {\n    chr = chrArray[i].name;\n    chrs.push(chr);\n    filledAnnots.push({chr: chr, annots: []});\n  }\n\n  for (i = 0; i < annots.length; i++) {\n    annot = annots[i];\n    chrIndex = chrs.indexOf(annot.chr);\n    if (chrIndex !== -1) {\n      filledAnnots[chrIndex] = annot;\n    }\n  }\n\n  return filledAnnots;\n}\n\nexport function applyRankCutoff(annots, cutoff, ideo) {\n  const rankedAnnots = sortAnnotsByRank(annots, ideo);\n\n  // Take the top N ranked genes, where N is `cutoff`\n  annots = rankedAnnots.slice(0, cutoff);\n\n  return annots;\n}\n\nexport function setAnnotRanks(annots, ideo) {\n  if ('geneCache' in ideo === false) return annots;\n\n  const ranks = ideo.geneCache.interestingNames;\n\n  return annots.map(annot => {\n    if (ranks.includes(annot.name)) {\n      annot.rank = ranks.indexOf(annot.name) + 1;\n    } else {\n      annot.rank = 1E10;\n    }\n    return annot;\n  });\n}\n\nexport function sortAnnotsByRank(annots, ideo) {\n\n  if (ideo) {\n    annots = setAnnotRanks(annots, ideo);\n  }\n  // Ranks annots by popularity\n  return annots.sort((a, b) => {\n\n    // // Search gene is most important, regardless of popularity\n    // if (a.color === 'red') return -1;\n    // if (b.color === 'red') return 1;\n\n    // Rank 3 is more important than rank 30\n    return a.rank - b.rank;\n  });\n}\n\nexport {\n  onLoadAnnots, onDrawAnnots, processAnnotData, restoreDefaultTracks,\n  updateDisplayedTracks, initAnnotSettings, fetchAnnots, drawAnnots,\n  getHistogramBars, drawHeatmaps, deserializeAnnotsForHeatmap, fillAnnots,\n  drawProcessedAnnots, drawSynteny, startHideAnnotTooltipTimeout,\n  showAnnotTooltip, onWillShowAnnotTooltip, onDidShowAnnotTooltip,\n  setOriginalTrackIndexes,\n  afterRawAnnots, onClickAnnot, downloadAnnotations, addAnnotLabel,\n  removeAnnotLabel, fillAnnotLabels, clearAnnotLabels, flattenAnnots\n  // fadeOutAnnotLabels\n};\n","/** Adds boxes behind a list of chromosomes; can indicate selection, etc. */\nfunction highlight(chrNames, color='red') {\n  const ideo = this;\n  const taxid = ideo.config.taxid;\n\n  const highlightsHtml = chrNames.map(chrName => {\n    const chrId = ideo.chromosomes[taxid][chrName].id;\n    const chrSet = `${ideo.selector} #${chrId}-chromosome-set`;\n    const chrDom = document.querySelector(chrSet);\n    const rect = chrDom.getBoundingClientRect();\n\n    const style = `style=\"\n      stroke-width: 1px;\n      stroke: ${color};\n      fill: ${color};\n      fill-opacity: 0.05;\n      position: absolute;\n      rx: 4;\n      ry: 4;\n      height: ${rect.width + 15}px;\n      width: ${rect.height + 15}px\"`;\n\n    const left = chrDom.transform.baseVal[1].matrix.f - 7.5;\n    const transform = `transform=\"rotate(90) translate(10, ${left})\"`;\n    const id = `id=\"ideo-highlight-${chrId}\"`;\n\n    return `<rect class=\"ideo-highlight\" ${id} ${style} ${transform}/>`;\n  }).join();\n\n  const ideoDom = document.querySelector(ideo.selector);\n  ideoDom.insertAdjacentHTML('afterBegin', highlightsHtml);\n}\n\n/** Removes highlight from a list of chromosomes (or all chromosomes)  */\nfunction unhighlight(chrNames) {\n  const ideo = this;\n\n  let highlightsSelector = `${ideo.selector} .ideo-highlight`;\n  if (typeof chrNames !== 'undefined') {\n    const taxid = ideo.config.taxid;\n    highlightsSelector = chrNames.map(chrName => {\n      const chrId = ideo.chromosomes[taxid][chrName].id;\n      return `${ideo.selector} #ideo-highlight-${chrId}`;\n    });\n  }\n\n  document.querySelectorAll(highlightsSelector).forEach((element) => {\n    element.remove();\n  });\n\n}\n\nexport {highlight, unhighlight};\n","import {d3, slug, fetchWithRetry} from '../lib';\n\n/**\n *  Returns NCBI Taxonomy identifier (taxid) for organism name\n */\nfunction getTaxidFromEutils(orgName, ideo) {\n  var taxonomySearch, taxid;\n\n  taxonomySearch = ideo.esearch + '&db=taxonomy&term=' + orgName;\n\n  return d3.json(taxonomySearch).then(function(data) {\n    var idlist = data.esearchresult.idlist;\n    if (idlist.length === 0) {\n      var warning =\n        'Organism \"' + orgName + '\" is generally unknown; it was not found ' +\n        'in the NCBI Taxonomy database.  If you did not intend to specify a ' +\n        'novel or custom taxon, then try using the organism\\'s ' +\n        'scientific name, e.g. Homo sapiens or Arabidopsis thaliana.';\n      throw warning;\n    } else {\n      taxid = data.esearchresult.idlist[0];\n      return [orgName, taxid];\n    }\n  });\n}\n\n/**\n * Returns organism common name given an NCBI Taxonomy ID\n *\n * @param taxid NCBI Taxonomy ID\n * @param callback Function to call upon completing ESearch request\n */\nfunction getOrganismFromEutils(taxid, callback) {\n  var organism, taxonomySearch,\n    ideo = this;\n\n  taxid = ideo.config.organism;\n\n  taxonomySearch = ideo.esummary + '&db=taxonomy&id=' + taxid;\n\n  d3.json(taxonomySearch).then(function(data) {\n    organism = data.result[String(taxid)].commonname;\n    ideo.config.organism = organism;\n    return callback(organism);\n  });\n}\n\nfunction setTaxidData(taxid, ideo) {\n\n  var dataDir, urlOrg, taxids;\n\n  if (ideo.assemblyIsAccession()) {\n    return new Promise(function(resolve) {\n      ideo.coordinateSystem = 'bp';\n      ideo.getAssemblyAndChromosomesFromEutils(taxid, resolve);\n    });\n  }\n\n  dataDir = ideo.config.dataDir;\n  urlOrg = slug(ideo.organisms[taxid].scientificName);\n\n  taxids = [taxid];\n\n  var fullyBandedTaxids = ['9606', '10090', '10116'];\n  if (fullyBandedTaxids.includes(taxid) && !ideo.config.showFullyBanded) {\n    urlOrg += '-no-bands';\n  }\n  var chromosomesUrl = dataDir + urlOrg + '.json';\n\n  var promise2 = new Promise((resolve, reject) => {\n    return fetchWithRetry(chromosomesUrl)\n      .then(response => {\n        return response.json().then(function(json) {\n          resolve(json);\n        });\n      })\n      .catch((errorMessage) => {\n        reject(errorMessage);\n      });\n  });\n\n  return promise2\n    .then(function(chrData) {\n      // Check if chromosome data exists locally.\n      // This is used for pre-processed centromere data,\n      // which is not accessible via EUtils.  See get_chromosomes.py.\n      var chrBands = chrData.chrBands\n\n      var asmAndChrTaxidsArray = [''],\n        chromosomes = [],\n        seenChrs = {},\n        chr, maxLength, splitBand, length;\n\n      ideo.bandData[chrData.taxid] = chrBands;\n\n      for (var i = 0; i < chrBands.length; i++) {\n        splitBand = chrBands[i].split(' ');\n        chr = splitBand[0];\n        length = splitBand.slice(-1)[0];\n        if (chr in seenChrs) {\n          continue;\n        } else {\n          chromosomes.push({name: chr, type: 'nuclear', length: length});\n          seenChrs[chr] = 1;\n        }\n      }\n      chromosomes = chromosomes.sort(Ideogram.sortChromosomes);\n      maxLength = {bp: 0, iscn: 0};\n      chromosomes.forEach(chr => {\n        if (chr.length > maxLength.bp) maxLength.bp = chr.length;\n      });\n      ideo.maxLength[taxid] = maxLength;\n      asmAndChrTaxidsArray.push(chromosomes);\n      asmAndChrTaxidsArray.push(taxids);\n      return asmAndChrTaxidsArray;\n    },\n    function() {\n      // If request in `then` errs (404), fetch data from EUtils\n      return new Promise(function(resolve) {\n        ideo.coordinateSystem = 'bp';\n        ideo.getAssemblyAndChromosomesFromEutils(taxid, resolve);\n      });\n    });\n}\n\nfunction setAssemblyAndChromosomes(taxid, resolve, ideo) {\n  var assembly, chrs, originalChrs, orgName, filteredChrs,\n    config = ideo.config;\n\n  setTaxidData(taxid, ideo)\n    .then(function(asmChrTaxidsArray) {\n      assembly = asmChrTaxidsArray[0];\n      chrs = asmChrTaxidsArray[1];\n\n      if ('chromosomes' in config === false || config.chromosomes === null) {\n        ideo.config.chromosomes = {};\n        ideo.config.chromosomes[taxid] = chrs;\n      } else {\n        if (config.multiorganism) {\n          if (taxid in config.chromosomes) {\n            // Encountered when either organism has centromere data\n            originalChrs = config.chromosomes[taxid];\n          } else {\n            // Encountered when neither organism has centromere data\n            orgName = slug(ideo.getScientificName(taxid));\n            ideo.config.chromosomes[taxid] =\n              config.chromosomes[orgName].slice();\n            originalChrs = ideo.config.chromosomes[taxid];\n            // delete ideo.config.chromosomes[orgName];\n          }\n        } else {\n          originalChrs = config.chromosomes;\n        }\n\n        filteredChrs = chrs.filter(d => originalChrs.includes(d.name));\n        ideo.config.chromosomes[taxid] = filteredChrs;\n      }\n      ideo.chromosomes[taxid] = ideo.config.chromosomes[taxid].slice();\n      ideo.organisms[taxid].assemblies = {\n        default: assembly\n      };\n      resolve();\n    });\n}\n\n/**\n * Determine if organism is natively supported, using its name.\n */\nfunction isOrganismSupported(org, ideo) {\n  var taxid, ideoOrg;\n\n  for (taxid in ideo.organisms) {\n    ideoOrg = ideo.organisms[taxid];\n    if (\n      taxid === slug(org) ||\n      slug(ideoOrg.commonName) === slug(org) ||\n      slug(ideoOrg.scientificName) === slug(org)\n    ) {\n      return true;\n    }\n  }\n\n  return false;\n}\n\n/**\n * Augment \"organisms\" metadata with for any requested organism that is\n * not natively supported (i.e., not in organism-metadata.js).\n*/\nfunction populateNonNativeOrg(orgs, ideo) {\n  var org, promise, i,\n    getTaxidFromEutilsPromises = [],\n    augmentedOrganismMetadata = {};\n\n  for (i = 0; i < orgs.length; i++) {\n    org = orgs[i];\n    if (isOrganismSupported(org, ideo) === false) {\n      promise = getTaxidFromEutils(org, ideo)\n        .then(function(orgNameAndTaxid) {\n\n          var taxid = orgNameAndTaxid[1],\n            orgName = orgNameAndTaxid[0],\n            name, scientificName;\n\n          name = orgName.replace('-', ' ');\n          scientificName = name[0].toUpperCase() + name.slice(1);\n\n          augmentedOrganismMetadata[taxid] = {\n            scientificName: scientificName,\n            commonName: '',\n            assemblies: {default: ''}\n          };\n\n          Object.assign(ideo.organisms, augmentedOrganismMetadata);\n        }, function(warning) {\n          console.warn(warning);\n          var customMetadata = {\n            scientificName: org,\n            commonName: org,\n            assemblies: {default: ''}\n          };\n\n          // Use a negative number as unofficial taxid for custom organism.\n          // Use case: https://github.com/eweitz/ideogram/issues/265\n          //\n          // If support for *multiple* custom specifies is ever\n          // needed, we can decrement from -1.\n          ideo.organisms['-1'] = customMetadata;\n          augmentedOrganismMetadata['-1'] = customMetadata;\n        });\n    } else {\n      promise = new Promise(function(resolve) {\n        var taxid = ideo.getTaxid(org);\n        augmentedOrganismMetadata[taxid] = ideo.organisms[taxid];\n        resolve();\n      });\n    }\n    getTaxidFromEutilsPromises.push(promise);\n  }\n\n  return Promise.all(getTaxidFromEutilsPromises).then(function() {\n    return augmentedOrganismMetadata;\n  });\n}\n\nfunction prepareTmpChrsAndTaxids(ideo) {\n  var orgs, taxids, tmpChrs, org, taxid, chrsOrgSlugs,\n    config = ideo.config;\n\n  taxids = [];\n  tmpChrs = {};\n  orgs = (config.multiorganism) ? config.organism : [config.organism];\n\n  return populateNonNativeOrg(orgs, ideo).then(function(orgMetadata) {\n    var orgFields = orgMetadata[taxid];\n\n    for (taxid in orgMetadata) {\n      orgFields = orgMetadata[taxid];\n      taxids.push(taxid);\n      if (config.multiorganism) {\n        if (typeof config.chromosomes !== 'undefined') {\n          chrsOrgSlugs = Object.keys(config.chromosomes).map(org => slug(org));\n          // Adjusts 'chromosomes' configuration parameter to make object\n          // keys use taxid instead of common organism name\n          if (chrsOrgSlugs.includes(slug(orgFields.scientificName))) {\n            org = orgFields.scientificName;\n          } else if (chrsOrgSlugs.includes(slug(orgFields.commonName))) {\n            org = orgFields.commonName;\n          }\n          if (slug(org) in config.chromosomes) {\n            tmpChrs[taxid] = config.chromosomes[slug(org)];\n          } else {\n            tmpChrs[taxid] = config.chromosomes[org.toLowerCase()];\n          }\n        } else {\n          tmpChrs = null;\n        }\n      }\n    }\n    return [tmpChrs, taxids];\n  });\n}\n\n/**\n * Sort taxids by the \"organism\" configuration option\n *\n * TODO: Handle taxid being passed as organism\n */\nfunction sortTaxidsByOriginalOrganismOption(ideo) {\n  var configOrganisms, sortedTaxids, i;\n  configOrganisms = ideo.config.organism;\n  sortedTaxids = [];\n  if (Array.isArray(configOrganisms)) {\n    // Handling multi-organism ideogram\n    for (i = 0; i < configOrganisms.length; i++) {\n      sortedTaxids.push(ideo.getTaxid(configOrganisms[i]));\n    }\n  } else {\n    // Handling single-organism ideogram\n    sortedTaxids.push(ideo.getTaxid(configOrganisms));\n  }\n  return sortedTaxids;\n}\n\nfunction getTaxidsForOrganismsInConfig(callback, ideo) {\n\n  prepareTmpChrsAndTaxids(ideo).then(function([tmpChrs, taxids]) {\n    var i, taxid, promise, assemblies, asmAccs,\n      config = ideo.config,\n      asmAndChrPromises = [];\n\n    for (i = 0; i < taxids.length; i++) {\n      taxid = taxids[i];\n      assemblies = ideo.organisms[taxid].assemblies;\n      asmAccs = Object.values(assemblies);\n      if (\n        assemblies.default === '' ||\n        ideo.assemblyIsAccession() && !asmAccs.includes(config.assembly)\n      ) {\n        promise = new Promise(function(resolve) {\n          setAssemblyAndChromosomes(taxid, resolve, ideo);\n        });\n      } else {\n        ideo.config.taxids = taxids;\n        if (ideo.config.multiorganism) {\n          ideo.config.chromosomes = tmpChrs;\n        }\n        promise = new Promise(function(resolve) {\n          resolve();\n        });\n      }\n\n      asmAndChrPromises.push(promise);\n    }\n\n    Promise.all(asmAndChrPromises).then(function() {\n      taxids = sortTaxidsByOriginalOrganismOption(ideo);\n      ideo.config.taxids = taxids;\n      return callback(taxids);\n    });\n  });\n}\n\nfunction getIsMultiorganism(taxidInit, ideo) {\n  return (\n    ('organism' in ideo.config && ideo.config.organism instanceof Array) ||\n    (taxidInit && ideo.config.taxid instanceof Array)\n  );\n}\n\n/**\n * Configure Ideogram taxids when 'organism' is not in ideo.config\n */\nfunction getTaxidsForOrganismsNotInConfig(taxidInit, callback, ideo) {\n  var taxids;\n\n  if (ideo.config.multiorganism) {\n    if (taxidInit) {\n      taxids = ideo.config.taxid;\n    }\n  } else {\n    if (taxidInit) {\n      taxids = [ideo.config.taxid];\n    }\n    ideo.config.taxids = taxids;\n  }\n  callback(taxids);\n}\n\n/**\n * Returns an array of taxids for the current ideogram\n * Also sets configuration parameters related to taxid(s), whether ideogram is\n * multiorganism, and adjusts chromosomes parameters as needed\n **/\nfunction getTaxids(callback) {\n  var taxidInit,\n    ideo = this;\n\n  taxidInit = 'taxid' in ideo.config;\n\n  ideo.config.multiorganism = getIsMultiorganism(taxidInit, ideo);\n\n  if (ideo.config.multiorganism) ideo.coordinateSystem = 'bp';\n\n  if ('organism' in ideo.config) {\n    const org = ideo.config.organism;\n    if (typeof org === 'string') {\n      // Canonicalize e.g. \"Homo sapiens\" to \"homo-sapiens\"\n      ideo.config.organism = slug(org.toLowerCase());\n    }\n\n    getTaxidsForOrganismsInConfig(callback, ideo);\n  } else {\n    getTaxidsForOrganismsNotInConfig(taxidInit, callback, ideo);\n  }\n}\n\nexport {\n  getTaxids, getOrganismFromEutils\n};\n","import {d3} from '../lib';\nimport {\n  esearch, esummary, elink, getAssemblySearchUrl\n} from './eutils-config.js';\nimport {\n  getTaxids, getOrganismFromEutils\n} from './organisms.js';\n\n/**\n * Get a URL to ESearch the NCBI Nucleotide DB for an Assembly UID\n */\nfunction getESearchUrlForChromosomes(asmUid, ideo) {\n  var qs;\n\n  // Get a list of IDs for the chromosomes in this genome.\n  //\n  // Query chromosomes sequences in Nucleotide DB (nuccore) via\n  // Assembly DB E-Utils link.\n  qs = ('&db=nuccore&dbfrom=assembly&linkname=assembly_nuccore&' +\n    'cmd=neighbor_history&from_uid=' + asmUid);\n\n  return d3.json(ideo.elink + qs)\n    .then(function(data) {\n      var webenv = data.linksets[0].webenv;\n      qs =\n        '&db=nuccore' +\n        '&term=%231+AND+%28' +\n          'sequence_from_chromosome[Properties]+OR+' +\n          'sequence_from_plastid[Properties]+OR+' +\n          'sequence_from_mitochondrion[Properties]%29' +\n        '&WebEnv=' + webenv + '&usehistory=y&retmax=1000';\n      return ideo.esearch + qs;\n    });\n}\n\n/**\n * Request basic data on a list of chromosome IDs from ESearch\n */\nfunction fetchNucleotideSummary(data, ideo) {\n  var ids, ntSummary;\n  ids = data.esearchresult.idlist.join(',');\n  ntSummary = ideo.esummary + '&db=nucleotide&id=' + ids;\n  return d3.json(ntSummary);\n}\n\n/**\n * Get name and type for mitochondrial chromosome\n *\n * See example of \"MT\" in yeast:\n * https://eweitz.github.io/ideogram/eukaryotes?org=saccharomyces-cerevisiae\n */\nfunction parseMitochondrion(result, ideo) {\n  var type, cnIndex, chrName;\n\n  if (ideo.config.showNonNuclearChromosomes) {\n    type = result.genome;\n    cnIndex = result.subtype.split('|').indexOf('plasmid');\n    if (cnIndex === -1) {\n      chrName = 'MT';\n    } else {\n      // Seen in e.g. rice genome IRGSP-1.0 (GCF_001433935.1),\n      // From https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?retmode=json&db=nucleotide&id=996703432,996703431,996703430,996703429,996703428,996703427,996703426,996703425,996703424,996703423,996703422,996703421,194033210,11466763,7524755\n      // genome: 'mitochondrion',\n      // subtype: 'cell_line|plasmid',\n      // subname: 'A-58 CMS|B1',\n      chrName = result.subname.split('|')[cnIndex];\n    }\n  } else {\n    return [null, null];\n  }\n\n  return [chrName, type];\n}\n\n/**\n * Get name and type for chloroplastic chromosome.\n *\n * Plants have chloroplasts.  See e.g. green algae:\n * https://eweitz.github.io/ideogram/eukaryotes?org=micromonas-commoda\n */\nfunction parseChloroplastOrPlastid(ideo) {\n  // Plastid encountered with rice genome IRGSP-1.0 (GCF_001433935.1)\n  if (ideo.config.showNonNuclearChromosomes) {\n    return ['CP', 'chloroplast'];\n  }\n  return [null, null];\n}\n\n/**\n * Get name and type for apicoplast chromosome\n *\n * Plasmodium falciparum (malaria parasite) has such a chromosome, see e.g.:\n * https://eweitz.github.io/ideogram/eukaryotes?org=plasmodium-falciparum\n */\nfunction parseApicoplast(ideo) {\n  if (ideo.config.showNonNuclearChromosomes) {\n    return ['AP', 'apicoplast'];\n  }\n  return [null, null];\n}\n\n/**\n * Get name and type for nuclear chromosome\n *\n * These are typical chromosomes, like chromosome 1.\n */\nfunction parseNuclear(result) {\n  var type, cnIndex, chrName;\n\n  type = 'nuclear';\n  cnIndex = result.subtype.split('|').indexOf('chromosome');\n  chrName = result.subname.split('|')[cnIndex];\n\n  if (typeof chrName !== 'undefined' && chrName.substr(0, 3) === 'chr') {\n    // Convert \"chr12\" to \"12\", e.g. for banana (GCF_000313855.2)\n    chrName = chrName.substr(3);\n  }\n\n  return [chrName, type];\n}\n\n/**\n * Get name and type of any chromosome object from NCBI Nucleotide ESummary\n */\nfunction getChrNameAndType(result, ideo) {\n  var genome = result.genome;\n  if (genome === 'mitochondrion') {\n    return parseMitochondrion(result, ideo);\n  } else if (genome === 'chloroplast' || genome === 'plastid') {\n    return parseChloroplastOrPlastid(ideo);\n  } else if (genome === 'apicoplast') {\n    return parseApicoplast(ideo);\n  } else {\n    return parseNuclear(result);\n  }\n}\n\nfunction parseChromosome(result, ideo) {\n  var chrName, type, chromosome;\n\n  [chrName, type] = getChrNameAndType(result, ideo);\n\n  chromosome = {\n    name: chrName,\n    length: result.slen,\n    type: type\n  };\n\n  return chromosome;\n}\n\nfunction parseChromosomes(results, taxid, ideo) {\n  var x, chromosome, seenChrId, maxLength,\n    seenChrs = {},\n    chromosomes = [];\n\n  for (x in results) {\n    // omit list of result uids\n    if (x === 'uids') continue;\n\n    chromosome = parseChromosome(results[x], ideo);\n    seenChrId = chromosome.name + '_' + chromosome.length;\n    if (chromosome.type !== null && seenChrId in seenChrs === false) {\n      // seenChrs accounts for duplicate chromosomes seen with\n      // pig (Sus scrofa), likely GenBank and RefSeq copies.\n      chromosomes.push(chromosome);\n    }\n\n    seenChrs[seenChrId] = 1;\n  }\n\n  chromosomes = chromosomes.sort(Ideogram.sortChromosomes);\n\n  maxLength = {bp: 0, iscn: 0};\n  chromosomes.forEach(chr => {\n    if (chr.length > maxLength.bp) maxLength.bp = chr.length;\n  });\n  if (maxLength.bp > ideo.maxLength.bp) ideo.maxLength.bp = maxLength.bp;\n  ideo.maxLength[taxid] = maxLength;\n  ideo.coordinateSystem = 'bp';\n\n  return chromosomes;\n}\n\n/**\n * Request ESummary data from an ESearch on a genome assembly\n */\nfunction fetchAssemblySummary(data, ideo) {\n  var asmUid, asmSummaryUrl;\n\n  // NCBI Assembly database's internal identifier (uid) for this assembly\n  asmUid = data.esearchresult.idlist[0];\n  asmSummaryUrl = ideo.esummary + '&db=assembly&id=' + asmUid;\n\n  return d3.json(asmSummaryUrl);\n}\n\n/**\n * Returns assembly accession, as well as names and lengths of chromosomes for\n * an organism's best-known genome assembly, or for a specified assembly.\n *\n * Gets data from NCBI EUtils web API.\n *\n * @param callback Function to call upon completion of this async method\n */\nfunction getAssemblyAndChromosomesFromEutils(taxid, callback) {\n  var assemblyAccession,\n    ideo = this;\n\n  // Search for assembly, then\n  // get summary of that assembly, then\n  // get search URL for chromosomes in that assembly, then\n  // get search results containing chromosome IDs, then\n  // get summaries of each of those chromosome IDs, then\n  // format the chromosome summaries and pass them into callback function.\n  var asmSearchUrl = getAssemblySearchUrl(taxid, ideo);\n  d3.json(asmSearchUrl)\n    .then(function(data) {return fetchAssemblySummary(data, ideo);})\n    .then(function(data) {\n      var asmUid = data.result.uids[0];\n      assemblyAccession = data.result[asmUid];\n      return getESearchUrlForChromosomes(asmUid, ideo);\n    }).then(function(esearchUrl) {return d3.json(esearchUrl);})\n    .then(function(data) {return fetchNucleotideSummary(data, ideo);})\n    .then(function(data) {\n      var chromosomes = parseChromosomes(data.result, taxid, ideo);\n      return callback([assemblyAccession, chromosomes]);\n    }, function(rejectedReason) {\n      console.warn(rejectedReason);\n    });\n}\n\nexport {\n  esearch, esummary, elink, getOrganismFromEutils,\n  getTaxids, getAssemblyAndChromosomesFromEutils\n};\n","// The E-Utilies In Depth: Parameters, Syntax and More:\n// https://www.ncbi.nlm.nih.gov/books/NBK25499/\n\nvar apiKey = '&api_key=7e33ac6a08a6955ec3b83d214d22b21a2808';\n\nvar eutils = 'https://eutils.ncbi.nlm.nih.gov/entrez/eutils/';\nvar esearch = eutils + 'esearch.fcgi?retmode=json' + apiKey;\nvar esummary = eutils + 'esummary.fcgi?retmode=json' + apiKey;\nvar elink = eutils + 'elink.fcgi?retmode=json' + apiKey;\n\nfunction getAssemblySearchUrl(taxid, ideo) {\n  var termStem, asmSearchUrl;\n\n  if (ideo.assemblyIsAccession()) {\n    termStem = ideo.config.assembly + '%22[Assembly%20Accession]';\n  } else {\n    termStem = (\n      taxid + '%22[taxid]' +\n      'AND%20(%22latest%20refseq%22[filter])%20'\n    );\n  }\n\n  asmSearchUrl =\n    ideo.esearch +\n    '&db=assembly' +\n    '&term=%22' + termStem +\n    'AND%20(%22chromosome%20level%22[filter]%20' +\n    'OR%20%22complete%20genome%22[filter])';\n\n  return asmSearchUrl;\n}\n\nexport {esearch, esummary, elink, getAssemblySearchUrl};\n","/**\n * @fileoverview Methods to show (or hide) cytogenetic banding data\n */\n\nimport {d3} from '../lib';\n\nfunction hideUnshownBandLabels() {\n  var ideo = this;\n  var bandsToShow = ideo.bandsToShow.join(',');\n\n  // Handles edge-case when ideogram consists of one chromosome\n  // that lacks bands in a genome that has bands (e.g. MT in human)\n  if (ideo.bandsToShow.length === 0) return;\n\n  // d3.selectAll resolves to querySelectorAll (QSA).\n  // QSA takes a surprisingly long time to complete,\n  // and scales with the number of selectors.\n  // Most bands are hidden, so we can optimize by\n  // Hiding all bands, then QSA'ing and displaying the\n  // relatively few bands that are shown.\n  d3.selectAll(ideo.selector + ' .bandLabel, .bandLabelStalk')\n    .style('display', 'none');\n  d3.selectAll(bandsToShow).style('display', '');\n}\n\nfunction getPrevRight(prevLabelXRight, prevHiddenBoxIndex, i,\n  textOffsets, chrModel) {\n  var prevTextBoxLeft, prevTextBoxWidth;\n\n  if (prevHiddenBoxIndex !== i) {\n    // This getBoundingClientRect() forces Chrome's\n    // 'Recalculate Style' and 'Layout', which takes 30-40 ms on Chrome.\n    // TODO: This forced synchronous layout would be nice to eliminate.\n    // prevTextBox = texts[i].getBoundingClientRect();\n    // prevLabelXRight = prevTextBox.left + prevTextBox.width;\n\n    // TODO: Account for number of characters in prevTextBoxWidth,\n    // maybe also zoom.\n    prevTextBoxLeft = textOffsets[chrModel.id][i];\n    prevTextBoxWidth = 36;\n\n    prevLabelXRight = prevTextBoxLeft + prevTextBoxWidth;\n  }\n\n  return prevLabelXRight;\n}\n\nfunction updateShown(indexesToShow, overlapRight, left, pad, prevRight, i,\n  isBefore) {\n  var hiddenIndex, doSkip,\n    thisRight = isBefore ? overlapRight : prevRight;\n\n  if (left < pad + thisRight) {\n    overlapRight = prevRight;\n    hiddenIndex = i;\n    doSkip = isBefore;\n  } else {\n    indexesToShow.push(i);\n  }\n\n  return [indexesToShow, overlapRight, hiddenIndex, doSkip];\n}\n\nfunction getIndexesToShow(offsets, chrModel) {\n  var i, hiddenIndex, left, prevRight, doSkip,\n    indexesToShow = [],\n    textsLength = offsets[chrModel.id].length,\n    overlapRight = 0, // Right X coordinate of overlapping label\n    pad = 5; // text padding\n\n  for (i = 0; i < textsLength; i++) {\n    // Ensures band labels don't overlap\n    left = offsets[chrModel.id][i];\n\n    [indexesToShow, overlapRight, hiddenIndex, doSkip] =\n      updateShown(indexesToShow, overlapRight, left, pad, prevRight, i, true);\n    if (doSkip) continue;\n\n    prevRight = getPrevRight(prevRight, hiddenIndex, i, offsets, chrModel);\n\n    [indexesToShow, overlapRight, hiddenIndex, doSkip] =\n      updateShown(indexesToShow, overlapRight, left, pad, prevRight, i, false);\n  }\n\n  return indexesToShow;\n}\n\n/**\n * Sets band labels to display on each chromosome, avoiding label overlap\n */\nfunction setBandsToShow(chrs, textOffsets) {\n  var index, i, j, indexesToShow, chrModel, selectorsToShow, ithLength,\n    ideo = this;\n\n  ideo.bandsToShow = [];\n\n  for (i = 0; i < chrs.length; i++) {\n\n    chrModel = chrs[i];\n\n    indexesToShow = getIndexesToShow(textOffsets, chrModel);\n\n    selectorsToShow = [];\n    ithLength = indexesToShow.length;\n\n    for (j = 0; j < ithLength; j++) {\n      index = indexesToShow[j];\n      selectorsToShow.push('#' + chrModel.id + ' .bsbsl-' + index);\n    }\n\n    ideo.bandsToShow = ideo.bandsToShow.concat(selectorsToShow);\n  }\n}\n\nexport {hideUnshownBandLabels, setBandsToShow};\n","/**\n * @fileoverview Methods to draw cytogenetic bands and their labels\n *\n */\n\nimport {d3} from '../lib';\nimport {hideUnshownBandLabels, setBandsToShow} from './show';\nimport {staticColors, staticGradients} from './styles';\nimport {configuredCss} from './../init/configure';\n\n/**\n * Draws text of cytoband label\n */\nfunction drawBandLabelText(chr, bandsToLabel, chrModel, textOffsets) {\n  var ideo = this,\n    layout = ideo._layout,\n    chrIndex = chrModel.chrIndex;\n\n  chr.selectAll('text')\n    .data(bandsToLabel)\n    .enter()\n    .append('g')\n    .attr('class', function(d, i) {\n      return 'bandLabel bsbsl-' + i;\n    })\n    .attr('transform', function(d) {\n      var transform = layout.getChromosomeBandLabelTranslate(d, chrIndex);\n\n      if (ideo.config.orientation === 'horizontal') {\n        textOffsets[chrModel.id].push(transform.x + 13);\n      } else {\n        textOffsets[chrModel.id].push(transform.y + 6);\n      }\n\n      return transform.translate;\n    })\n    .append('text')\n    .attr('text-anchor', layout.getChromosomeBandLabelAnchor(chrIndex))\n    .text(function(d) {return d.name;});\n\n  return textOffsets;\n}\n\n/**\n * Draws line between cytoband and its text label\n */\nfunction drawBandLabelStalk(chr, bandsToLabel, chrModel, textOffsets) {\n  var ideo = this;\n\n  chr.selectAll('line.bandLabelStalk')\n    .data(bandsToLabel)\n    .enter()\n    .append('g')\n    .attr('class', function(d, i) {\n      return 'bandLabelStalk bsbsl-' + i;\n    })\n    .attr('transform', function(d) {\n      var x, y;\n\n      x = ideo.round(d.px.start + d.px.width / 2);\n      y = -10;\n\n      textOffsets[chrModel.id].push(x + 13);\n\n      return 'translate(' + x + ',' + y + ')';\n    })\n    .append('line')\n    .attr('x1', 0)\n    .attr('y1', ideo._layout.getChromosomeBandTickY1(chrModel.chrIndex))\n    .attr('x2', 0)\n    .attr('y2', ideo._layout.getChromosomeBandTickY2(chrModel.chrIndex));\n}\n\nfunction getChrModels(chromosomes) {\n  var taxid, chr,\n    chrModels = [];\n\n  for (taxid in chromosomes) {\n    for (chr in chromosomes[taxid]) {\n      chrModels.push(chromosomes[taxid][chr]);\n    }\n  }\n\n  return chrModels;\n}\n\n/**\n * Draws text and stalks for cytogenetic band labels.\n *\n * Band labels are text like \"p11.11\".\n * Stalks are small lines that visually connect labels to their bands.\n */\nfunction drawBandLabels(chromosomes) {\n  var i, chr, chrModel, chrModels, bandsToLabel,\n    ideo = this,\n    textOffsets = {};\n\n  chrModels = getChrModels(chromosomes);\n\n  for (i = 0; i < chrModels.length; i++) {\n    chrModel = chrModels[i];\n    chr = d3.select(ideo.selector + ' #' + chrModel.id);\n    textOffsets[chrModel.id] = [];\n\n    // Don't show \"pter\" label for telocentric chromosomes, e.g. mouse\n    bandsToLabel = chrModel.bands.filter(d => d.name !== 'pter');\n\n    textOffsets =\n      ideo.drawBandLabelText(chr, bandsToLabel, chrModel, textOffsets);\n\n    ideo.drawBandLabelStalk(chr, bandsToLabel, chrModel, textOffsets);\n  }\n\n  ideo.setBandsToShow(chrModels, textOffsets);\n}\n\nfunction getStainAndColors(i, colors) {\n  var stain, color1, color2, color3;\n\n  stain = colors[i][0];\n  color1 = colors[i][1];\n  color2 = colors[i][2];\n  color3 = colors[i][3];\n\n  return [stain, color1, color2, color3];\n}\n\nfunction getGradients(colors) {\n  var i, stain, color1, color2, color3,\n    gradients = '';\n\n  for (i = 0; i < colors.length; i++) {\n    [stain, color1, color2, color3] = getStainAndColors(i, colors);\n    gradients +=\n      '<linearGradient id=\"' + stain + '\" x1=\"0%\" y1=\"0%\" x2=\"0%\" y2=\"100%\">';\n    if (stain === 'gneg') {\n      gradients +=\n        '<stop offset=\"70%\" stop-color=\"' + color2 + '\" />' +\n        '<stop offset=\"95%\" stop-color=\"' + color3 + '\" />' +\n        '<stop offset=\"100%\" stop-color=\"' + color1 + '\" />';\n    } else {\n      gradients +=\n        '<stop offset=\"5%\" stop-color=\"' + color1 + '\" />' +\n        '<stop offset=\"15%\" stop-color=\"' + color2 + '\" />' +\n        '<stop offset=\"60%\" stop-color=\"' + color3 + '\" />';\n    }\n    gradients +=\n      '</linearGradient>';\n  }\n\n  return gradients;\n}\n\n/**\n * Returns SVG gradients that give chromosomes a polished look\n */\nfunction getBandColorGradients() {\n  var css,\n    gradients = '';\n\n  gradients = getGradients(staticColors);\n\n  css = `<style>${configuredCss}</style>`;\n\n  gradients += staticGradients;\n  gradients = '<defs>' + gradients + '</defs>';\n  gradients = css + gradients;\n\n  return gradients;\n}\n\nexport {\n  drawBandLabels, getBandColorGradients, hideUnshownBandLabels, setBandsToShow,\n  drawBandLabelText, drawBandLabelStalk\n};\n","\nfunction getDelimiterTsvLinesAndInit(source, content) {\n  var delimiter, tsvLines, init;\n\n  if (typeof chrBands === 'undefined' && source !== 'native') {\n    delimiter = /\\t/;\n    tsvLines = content.split(/\\r\\n|\\n/);\n    init = 1;\n  } else {\n    delimiter = / /;\n    tsvLines = content;\n    init = 0;\n  }\n\n  return [delimiter, tsvLines, init];\n}\n\nfunction updateChromosomes(chromosomes) {\n  var tmp, i;\n\n  if (chromosomes instanceof Array && typeof chromosomes[0] === 'object') {\n    tmp = [];\n    for (i = 0; i < chromosomes.length; i++) {\n      tmp.push(chromosomes[i].name);\n    }\n    chromosomes = tmp;\n  }\n  return chromosomes;\n}\n\nfunction getLineObject(chr, columns, stain, taxid) {\n  return {\n    chr: chr,\n    bp: {\n      start: parseInt(columns[5], 10),\n      stop: parseInt(columns[6], 10)\n    },\n    iscn: {\n      start: parseInt(columns[3], 10),\n      stop: parseInt(columns[4], 10)\n    },\n    px: {\n      start: -1,\n      stop: -1,\n      width: -1\n    },\n    name: columns[1] + columns[2],\n    stain: stain,\n    taxid: taxid\n  };\n}\n\nfunction getStain(columns) {\n  var stain = columns[7];\n  // For e.g. acen and gvar, columns[8] (density) is undefined\n  if (columns[8]) stain += columns[8];\n  return stain;\n}\n\nfunction updateLines(lines, columns, taxid) {\n  var chr, stain, line;\n\n  chr = columns[0];\n  if (chr in lines === false) lines[chr] = [];\n\n  stain = getStain(columns);\n\n  line = getLineObject(chr, columns, stain, taxid);\n  lines[chr].push(line);\n\n  return lines;\n}\n\n/**\n * Reports if a cytogenetic band should be included in parse results\n *\n * TODO:\n * Normalize ideogram.chromosomes upstream.\n *\n * This function is complex because ideogram.chromosomes is (likely\n * unnecessarily) complex.  The \"ideogram.chromosomes\" object can\n * take many forms depending on the use case, and this results in\n * hard-to-reason-about functions like this.\n *\n * Normalizing ideogram.chromosomes to a common format somewhere upstream\n * would likely make this specific function and Ideogram in general much\n * more maintainable.\n */\nfunction shouldSkipBand(chrs, chr, taxid, ideo) {\n\n  var hasChrs, chrsAreList, chrNotInList, chrsAreObject,\n    innerChrsAreStrings, matchingChrObjs, chrNotInObject,\n    multiorganism = ideo.config.multiorganism;\n\n  hasChrs = typeof chrs !== 'undefined' && chrs !== null;\n  if (!hasChrs) return false;\n\n  chrsAreList = Array.isArray(chrs);\n  chrNotInList = chrsAreList && chrs.indexOf(chr) === -1;\n  chrsAreObject = typeof chrs === 'object';\n\n  if (chrsAreList && !chrsAreObject && chrNotInList) return true;\n\n  if (taxid in chrs === false && multiorganism) return false;\n\n  if (!multiorganism) {\n    // Encountered in single organism when showing subset of all chromosomes,\n    // e.g. only human X and Y as in https://eweitz.github.io/ideogram/homology-basic\n    matchingChrObjs = chrs.filter(thisChr => thisChr === chr);\n    chrNotInObject = matchingChrObjs.length === 0;\n  } else {\n    innerChrsAreStrings = typeof chrs[taxid][0] === 'string';\n    if (innerChrsAreStrings) {\n      chrNotInObject = chrs[taxid].includes(chr) === false;\n    } else {\n      matchingChrObjs = chrs[taxid].filter(thisChr => thisChr.name === chr);\n      chrNotInObject = matchingChrObjs.length === 0;\n    }\n  }\n  return chrNotInObject;\n\n}\n\n/**\n * Parses cytogenetic band data from a TSV file, or, if band data is\n * prefetched, from an array\n *\n * NCBI:\n * #chromosome arm band iscn_start iscn_stop bp_start bp_stop stain density\n * ftp://ftp.ncbi.nlm.nih.gov/pub/gdp/ideogram_9606_GCF_000001305.14_550_V1\n */\nfunction parseBands(taxid, chromosomes, ideo) {\n  var delimiter, tsvLines, columns, chr, i, init, source, content,\n    lines = {};\n\n  content = ideo.bandData[taxid];\n\n  if (Array.isArray(content)) source = 'native';\n\n  chromosomes = updateChromosomes(chromosomes);\n\n  // Destructure assignment fails oddly when transpiled.  2019-05-23\n  var result = getDelimiterTsvLinesAndInit(source, content);\n  delimiter = result[0];\n  tsvLines = result[1];\n  init = result[2];\n\n  for (i = init; i < tsvLines.length; i++) {\n    columns = tsvLines[i].split(delimiter);\n\n    chr = columns[0];\n    if (shouldSkipBand(chromosomes, chr, taxid, ideo)) {\n      // If specific chromosomes are configured, then skip processing all\n      // other fetched chromosomes.\n      continue;\n    }\n\n    lines = updateLines(lines, columns, taxid);\n  }\n\n  return lines;\n}\n\nexport {parseBands};\n","/**\n * @fileoverview Methods for processing chromosome length and banding data.\n *\n * Ideogram.js depicts chromosomes using data on their length, name, and\n * (if dealing with a very well-studied organism) cytogenetic banding data.\n * This file processes cytoband data that comes from biological research\n * institutions.\n *\n * For background on cytogenetic bands and how they are used in genomics, see:\n * https://ghr.nlm.nih.gov/primer/howgeneswork/genelocation\n *\n */\n\nimport {\n  drawBandLabels, getBandColorGradients, hideUnshownBandLabels, setBandsToShow,\n  drawBandLabelText, drawBandLabelStalk\n} from './draw';\nimport {parseBands} from './parse';\nimport {organismMetadata} from '../init/organism-metadata';\n\n/**\n * Gets bands array for given chromosomes, sets ideo.maxLength\n */\nfunction getBandsArray(chromosome, bandsByChr, taxid, ideo) {\n  var bands, chrLength,\n    bandsArray = [];\n\n  bands = bandsByChr[chromosome];\n  bandsArray.push(bands);\n\n  chrLength = {\n    iscn: bands[bands.length - 1].iscn.stop,\n    bp: bands[bands.length - 1].bp.stop\n  };\n\n  if (taxid in ideo.maxLength === false) {\n    ideo.maxLength[taxid] = {bp: 0, iscn: 0};\n  }\n\n  if (chrLength.iscn > ideo.maxLength[taxid].iscn) {\n    ideo.maxLength[taxid].iscn = chrLength.iscn;\n    if (chrLength.iscn > ideo.maxLength.iscn) {\n      ideo.maxLength.iscn = chrLength.iscn;\n    }\n  }\n\n  if (chrLength.bp > ideo.maxLength[taxid].bp) {\n    ideo.maxLength[taxid].bp = chrLength.bp;\n    if (chrLength.bp > ideo.maxLength.bp) {\n      ideo.maxLength.bp = chrLength.bp;\n    }\n  }\n\n  return bandsArray;\n}\n\n/**\n * Updates bandsArray, sets ideo.config.chromosomes and ideo.numChromosomes\n */\nfunction setChrsByTaxidsWithBands(taxid, chrs, bandsArray, ideo) {\n  var bandsByChr, chromosome, k, chrBandsArray;\n\n  bandsByChr = parseBands(taxid, chrs, ideo);\n\n  chrs = Object.keys(bandsByChr).sort(Ideogram.sortChromosomes);\n\n  if (\n    'chromosomes' in ideo.config === false ||\n    ideo.config.chromosomes === null\n  ) {\n    ideo.config.chromosomes = {};\n  }\n  if (chrs.length > 0) {\n    ideo.config.chromosomes[taxid] = chrs.slice();\n  }\n  ideo.numChromosomes += ideo.config.chromosomes[taxid].length;\n\n  for (k = 0; k < chrs.length; k++) {\n    chromosome = chrs[k];\n    chrBandsArray = getBandsArray(chromosome, bandsByChr, taxid, ideo);\n    bandsArray = bandsArray.concat(chrBandsArray);\n  }\n\n  return bandsArray;\n}\n\nfunction setChromosomesByTaxid(taxid, chrs, bandsArray, ideo) {\n  var chr, i;\n\n  if (\n    taxid in ideo.bandData ||\n    taxid in organismMetadata &&\n    ideo.assemblyIsAccession() === false\n  ) {\n    bandsArray = setChrsByTaxidsWithBands(taxid, chrs, bandsArray, ideo);\n  } else {\n    // If lacking band-level data\n    ideo.numChromosomes += chrs.length;\n\n    for (i = 0; i < chrs.length; i++) {\n      chr = chrs[i];\n      if (chr.length > ideo.maxLength.bp) ideo.maxLength.bp = chr.length;\n    }\n  }\n\n  return bandsArray;\n}\n\nfunction reportPerformance(t0, ideo) {\n  var t1 = new Date().getTime();\n  if (ideo.config.debug) {\n    console.log('Time in processBandData: ' + (t1 - t0) + ' ms');\n  }\n}\n\n/**\n * Completes default ideogram initialization by calling downstream functions\n * to process raw band data into full JSON objects, render chromosome and\n * cytoband figures and labels, apply initial graphical transformations,\n * hide overlapping band labels, and execute callbacks defined by client code\n */\nfunction processBandData(taxid) {\n  var bandsArray, chrs,\n    ideo = this,\n    config = ideo.config,\n    t0 = new Date().getTime();\n\n  bandsArray = [];\n\n  if ('chromosomes' in config) {\n    if (config.multiorganism) {\n      // Copy object\n      chrs = config.chromosomes;\n    } else if (taxid in config.chromosomes) {\n      // Copy array by value\n      chrs = config.chromosomes[taxid].slice();\n    } else {\n      // Copy array by value.  Needed for e.g. \"Homology, basic\"\n      chrs = config.chromosomes.slice();\n    }\n  }\n\n  bandsArray = setChromosomesByTaxid(taxid, chrs, bandsArray, ideo);\n\n  reportPerformance(t0, ideo);\n  return [taxid, bandsArray];\n}\n\nexport {\n  drawBandLabels, getBandColorGradients, processBandData,\n  setBandsToShow, hideUnshownBandLabels, drawBandLabelText, drawBandLabelStalk\n};\n","/**\n * @fileoverview Methods to create and handle a brush on a chromosome.\n *\n * Ideogram.js enables users to display a box around part of a chromosome\n * that represents a \"currently selected\" region.  The user can move this\n * box like a sliding window, e.g. by clicking and dragging the mouse.\n *\n * For background, see:\n * https://github.com/d3/d3-brush\n */\n\nimport {d3} from './lib';\n\n/**\n * Custom event handler, fired upon dragging sliding window on chromosome\n */\nfunction onBrushMove() {\n  call(this.onBrushMoveCallback);\n}\n\nfunction onBrushEnd() {\n  call(this.onBrushEndCallback);\n}\n\nfunction setBrush(bpDomain, pxRange, xOffset, width, ideo) {\n  var xScale,\n    length = ideo.config.chrHeight;\n\n  xScale = d3.scaleLinear().domain(bpDomain).range(pxRange);\n\n  ideo.brush = d3.brushX()\n    .extent([[xOffset, 0], [length + xOffset, width]])\n    .on('brush', _onBrushMove)\n    .on('end', _onBrushEnd);\n\n  function _onBrushMove({selection}) {\n    var extent = selection.map(xScale.invert),\n      from = Math.floor(extent[0]),\n      to = Math.ceil(extent[1]);\n\n    ideo.selectedRegion = {from: from, to: to, extent: (to - from)};\n\n    if (ideo.onBrushMoveCallback) {\n      ideo.onBrushMoveCallback();\n    }\n  }\n\n  function _onBrushEnd({selection}) {\n    if (ideo.onBrushEndCallback) {\n      ideo.onBrushEndCallback();\n    }\n  }\n}\n\nfunction getBasePairDomainAndPixelRange(chrModel, xOffset) {\n  var band, i,\n    bpDomain = [1],\n    pxRange = [1],\n    lastBand = chrModel.bands.slice(-1)[0];\n\n  for (i = 0; i < chrModel.bands.length; i++) {\n    band = chrModel.bands[i];\n    bpDomain.push(band.bp.start);\n    pxRange.push(band.px.start + xOffset);\n  }\n\n  bpDomain.push(lastBand.bp.stop - 1);\n  pxRange.push(lastBand.px.stop + xOffset);\n\n  return [bpDomain, pxRange];\n}\n\n/**\n * Account for calls like createBrush('chr1:104325484-119977655')\n */\nfunction refineGenomicCoordinates(chr, from, to) {\n  var nameSplit, fromToSplit;\n\n  // Account for calls like createBrush('chr1:104325484-119977655')\n  nameSplit = chr.split(':');\n  fromToSplit = chr.split('-');\n  if (nameSplit.length > 1 && fromToSplit.length > 1) {\n    chr = nameSplit[0].replace('chr', '');\n    fromToSplit = nameSplit[1].split('-');\n    from = parseInt(fromToSplit[0]);\n    to = parseInt(fromToSplit[1] - 1);\n  }\n\n  return [chr, from, to];\n}\n\nfunction getChrModel(chr, ideo) {\n  var i, cm, chrModel;\n\n  for (i = 0; i < ideo.chromosomesArray.length; i++) {\n    cm = ideo.chromosomesArray[i];\n    if (cm.name === chr) {\n      chrModel = cm;\n      return chrModel;\n    }\n  }\n}\n\nfunction writeBrush(chrModel, from, to, xOffset, width, ideo) {\n  var x0, x1, yTranslate, yOffset;\n\n  x0 = ideo.convertBpToPx(chrModel, from) + xOffset;\n  x1 = ideo.convertBpToPx(chrModel, to) + xOffset;\n\n  yTranslate = ideo._layout.getChromosomeSetYTranslate(0);\n  yOffset = yTranslate + (ideo.config.chrWidth - width) / 2;\n\n  d3.select(ideo.selector).append('g')\n    .attr('class', 'brush')\n    .attr('transform', 'translate(0, ' + yOffset + ')')\n    .call(ideo.brush)\n    .call(ideo.brush.move, [x0, x1]);\n}\n\nfunction setSelectedRegion(from, to, ideo) {\n  // Genomics web UIs are 1-based, fully closed.\n  // I.e. If start = 20 bp and stop = 10 bp, then extent = 11 bp.\n  // Details:\n  // http://genome.ucsc.edu/blog/the-ucsc-genome-browser-coordinate-counting-systems/\n  // https://www.biostars.org/p/84686/\n  var extent = to - from + 1;\n  ideo.selectedRegion = {from: from, to: to, extent: extent};\n}\n\n/**\n * Creates a sliding window along a chromosome\n *\n * @param chr Chromosome name (e.g. 1) or range, e.g. chr1:104325484-119977655\n * @param from Genomic start coordinate in base pairs, e.g. 104325484\n * @param to Genomic end coordinate in base pairs, e.g. 119977655\n */\nfunction createBrush(chr, from, to) {\n  var chrModel, chrLengthBp, bpDomain, pxRange, lastBand,\n    ideo = this,\n    width = ideo.config.chrWidth + 6.5,\n    xOffset = ideo._layout.margin.left;\n\n  [chr, from, to] = refineGenomicCoordinates(chr, from, to);\n\n  chrModel = getChrModel(chr, ideo);\n\n  [bpDomain, pxRange] = getBasePairDomainAndPixelRange(chrModel, xOffset);\n\n  lastBand = chrModel.bands.slice(-1)[0];\n  chrLengthBp = lastBand.bp.stop;\n\n  if (typeof from === 'undefined') from = Math.floor(chrLengthBp / 10);\n  if (typeof to === 'undefined') to = Math.ceil(from * 2);\n\n  setBrush(bpDomain, pxRange, xOffset, width, ideo);\n\n  setSelectedRegion(from, to, ideo);\n  writeBrush(chrModel, from, to, xOffset, width, ideo);\n}\n\nexport {onBrushMove, onBrushEnd, createBrush};\n","/**\n * @fileoverview Allows a click event handler to be attached to the ideogram\n *\n * This works similar to the \"brush\" which allows a region to be selected.\n * The click handler does not allow a region, but a precise location.\n *\n */\n\nimport {d3} from './lib';\n\n/**\n * Custom event handler, fired upon clicks on the chromosome (to change\n * position)\n */\nfunction onCursorMove() {\n  call(this.onCursorMoveCallback);\n}\n\nfunction setCursor(position, bpDomain, pxRange, xOffset, width, ideo) {\n  var xScale;\n\n  xScale = d3.scaleLinear().domain(bpDomain).range(pxRange);\n\n  if (!('rotatable' in ideo.config && ideo.config.rotatable === false)) {\n    console.warn('Using the cursor with rotate is not supported.');\n  }\n\n  var yTranslate = ideo._layout.getChromosomeSetYTranslate(0);\n  var yOffset = yTranslate + (ideo.config.chrWidth - width) / 2;\n\n  // TODO: check if newPosition is valid value (in range)\n\n  var cursorBrush = d3.select(ideo.selector).append('g')\n    .attr('class', 'brush')\n    .attr('transform', 'translate(0, ' + yOffset + ')')\n    .append('rect')\n    .attr('class', 'cursor')\n    .attr('x', xScale(position))\n    .attr('y', 0)\n    .attr('width', 1) // this could be a configuration param\n    .attr('height', 30); // MAGIC NUMBER! need help with this one\n\n  // call the callback for the first time (onLoad)\n  if (ideo.onCursorMove) {\n    ideo.onCursorMoveCallback(position);\n  }\n\n  if (!ideo.setCursorPosition) {\n    ideo.setCursorPosition = function(newPosition) {\n      // TODO: check if newPosition is valid value (in range)\n      cursorBrush.attr('x', xScale(newPosition));\n      if (ideo.onCursorMove) {\n        ideo.onCursorMoveCallback(newPosition);\n      }\n    };\n  }\n\n  d3.selectAll(ideo.selector + ' .chromosome').on('click', function(event) {\n    var x = event.offsetX; // minimum value seems to be 25\n\n    // adjust for screen (6 is a magic number that seems to work)\n    x -=6;\n\n    // move the cursor\n    cursorBrush.attr('x', x);\n\n    // calculate the new position and perform callback\n    var newPosition = Math.floor(xScale.invert(x));\n    if (ideo.onCursorMove) {\n      ideo.onCursorMoveCallback(newPosition);\n    }\n  });\n}\n\nfunction getBasePairDomainAndPixelRange(chrModel, xOffset) {\n  var band, i,\n    bpDomain = [1],\n    pxRange = [1],\n    lastBand = chrModel.bands.slice(-1)[0];\n\n  for (i = 0; i < chrModel.bands.length; i++) {\n    band = chrModel.bands[i];\n    bpDomain.push(band.bp.start);\n    pxRange.push(band.px.start + xOffset);\n  }\n\n  bpDomain.push(lastBand.bp.stop - 1);\n  pxRange.push(lastBand.px.stop + xOffset);\n\n  return [bpDomain, pxRange];\n}\n\nfunction getChrModel(chr, ideo) {\n  var i, cm, chrModel;\n\n  for (i = 0; i < ideo.chromosomesArray.length; i++) {\n    cm = ideo.chromosomesArray[i];\n    if (cm.name === chr) {\n      chrModel = cm;\n      return chrModel;\n    }\n  }\n}\n\n/**\n * Creates a clickable cursor along a chromosome.\n *\n * @param position Genomic start coordinate in base pairs, e.g. 104325484\n */\nfunction createClickCursor(position) {\n  var chrModel, bpDomain,\n    pxRange,\n    ideo = this,\n    width = ideo.config.chrWidth + 6.5, // 6.5 magic number?\n    xOffset = ideo._layout.margin.left;\n\n  if (typeof position === 'undefined') {\n    return false;\n  }\n\n  chrModel = getChrModel(ideo.config.chromosome, ideo);\n  [bpDomain, pxRange] = getBasePairDomainAndPixelRange(chrModel, xOffset);\n\n  // call setCursor to complete the job.\n  setCursor(position, bpDomain, pxRange, xOffset, width, ideo);\n}\n\nexport {onCursorMove, createClickCursor};\n","/**\n * @fileoverview Instance methods for sex chromosomes (allosomes).\n *\n * This module provides methods for drawing karyotypically normal\n * male and female mammalian genomes.\n */\n\n/**\n * Appends SVG elements depicting sex chromosomes to the document.\n */\nfunction drawSexChromosomes(container, chrIndex) {\n  var bandsArray, taxid, chrs,\n    sexChromosomeIndexes, sciLength,\n    chromosome, bands, chrModel, sci, homologIndex;\n\n  bandsArray = this.bandsArray;\n  taxid = this.config.taxid;\n  chrs = this.config.chromosomes[taxid];\n\n  if (this.config.sex === 'male') {\n    sexChromosomeIndexes = [1, 0];\n  } else {\n    sexChromosomeIndexes = [0, 0];\n  }\n\n  sciLength = sexChromosomeIndexes.length;\n\n  for (homologIndex = 0; homologIndex < sciLength; homologIndex++) {\n    sci = sexChromosomeIndexes[homologIndex] + chrIndex;\n    chromosome = chrs[sci];\n    bands = bandsArray[taxid][sci];\n    chrModel = this.getChromosomeModel(bands, chromosome, taxid, sci);\n    this.appendHomolog(chrModel, chrIndex, homologIndex, container);\n  }\n}\n\n/**\n * Sets instance properties regarding sex chromosomes.\n * Currently only supported for mammals.\n * TODO: Support all sexually reproducing taxa\n *   XY sex-determination (mammals):\n *     - Male: XY <- heterogametic\n *     - Female: XX\n *   ZW sex-determination (birds):\n *     - Male: ZZ\n *     - Female: ZW <- heterogametic\n *   X0 sex-determination (some insects):\n *     - Male: X0, i.e. only X <- heterogametic?\n *     - Female: XX\n * TODO: Support sex chromosome aneuploidies in mammals\n *     - Turner syndrome: X0\n *     - Klinefelter syndome: XXY\n *  More types:\n *  https://en.wikipedia.org/wiki/Category:Sex_chromosome_aneuploidies\n */\nfunction setSexChromosomes(chrs) {\n  var chr, i,\n    ideo = this,\n    sexChrs = {X: 1, Y: 1};\n\n  if (this.config.ploidy !== 2 || !this.config.sex) return;\n\n  ideo.sexChromosomes.list = [];\n\n  for (i = 0; i < chrs.length; i++) {\n    chr = chrs[i];\n    if (ideo.config.sex === 'male' && chr in sexChrs) {\n      ideo.sexChromosomes.list.push(chr);\n      if (!ideo.sexChromosomes.index) {\n        ideo.sexChromosomes.index = i;\n      }\n    } else if (chr === 'X') {\n      ideo.sexChromosomes.list.push(chr, chr);\n      ideo.sexChromosomes.index = i;\n    }\n  }\n}\n\nexport {drawSexChromosomes, setSexChromosomes};\n","/**\n * @fileoverview Methods to convert to and from different types of coordinates.\n *\n * Ideogram.js uses multiple coordinate systems, e.g. base pairs (bp) and\n * pixels (px).  These methods interconvert between those coordinate systems.\n *\n * TODO:\n * - Add methods to interconvert between ISCN coordinates and base pairs,\n * pixels.\n */\n\nfunction throwBpToPxError(bp, chr, band) {\n  throw new Error(\n    'Base pair out of range.  ' +\n    'bp: ' + bp + '; length of chr' + chr.name + ': ' + band.bp.stop\n  );\n}\n\nfunction getPx(chr, bp) {\n  var i, px, band, bpToIscnScale, iscn, iscnStart, iscnStop, iscnLength,\n    bpStart, bpStop, bpLength, pxStart, pxLength;\n\n  for (i = 0; i < chr.bands.length; i++) {\n    band = chr.bands[i];\n    bpStart = band.bp.start;\n    bpStop = band.bp.stop;\n    bpLength = bpStop - bpStart;\n    iscnStart = band.iscn.start;\n    iscnStop = band.iscn.stop;\n    iscnLength = iscnStop - iscnStart;\n    pxStart = band.px.start;\n    pxLength = band.px.width;\n\n    if (bp >= bpStart && bp <= bpStop) {\n      bpToIscnScale = iscnLength / bpLength;\n      iscn = iscnStart + (bp - bpStart) * bpToIscnScale;\n      px = pxStart + (pxLength * (iscn - iscnStart) / (iscnLength));\n\n      return [px, band];\n    }\n  }\n  return [null, band];\n}\n\n/**\n * Converts base pair coordinates to pixel offsets.\n * Bp-to-pixel scales differ among cytogenetic bands.\n *\n * For example, if we want to depict a gene on a chromosome, then we need\n * to convert the gene's location in base pairs to a location in pixels offset\n * from the start of the chromosome.\n */\nfunction convertBpToPx(chr, bp) {\n  var band, px;\n\n  if (chr.bands.length > 1 || chr.name === 'MT') {\n    [px, band] = getPx(chr, bp);\n    if (px !== null) return px;\n  } else if (bp >= 1 && bp <= chr.length) {\n    px = chr.scale.bp * bp;\n    return px;\n  }\n\n  throwBpToPxError(bp, chr, band);\n}\n\nfunction throwPxToBpError(px, chr, pxStop) {\n  throw new Error(\n    'Pixel out of range.  ' +\n    'px: ' + px + '; length of chr' + chr.name + ': ' + pxStop\n  );\n}\n\nfunction getBp(iscnStop, iscnStart, px, pxStop, pxStart, band, iscnLength) {\n  var pxLength, bpLength, pxToIscnScale, iscn, bp;\n\n  iscnLength = iscnStop - iscnStart;\n  pxLength = pxStop - pxStart;\n  bpLength = band.bp.stop - band.bp.start;\n\n  pxToIscnScale = iscnLength / pxLength;\n  iscn = iscnStart + (px - pxStart) * pxToIscnScale;\n\n  bp = band.bp.start + (bpLength * (iscn - iscnStart) / iscnLength);\n\n  return Math.round(bp);\n}\n\n/**\n * Converts pixel offsets to base pair coordinates.\n * Pixel-to-bp scales differ among cytogenetic bands.\n *\n * For example, if we want to determine the genomic location a user clicked on\n * (e.g. when creating a brush / sliding window region), then we need to\n * convert pixels to base pairs.\n */\nfunction convertPxToBp(chr, px) {\n  var i, band, bp, pxStart, pxStop, iscnStart, iscnStop, iscnLength;\n\n  if (px === 0) {\n    px = chr.bands[0].px.start;\n  }\n\n  for (i = 0; i < chr.bands.length; i++) {\n    band = chr.bands[i];\n\n    pxStart = band.px.start;\n    pxStop = band.px.stop;\n    iscnStart = band.iscn.start;\n    iscnStop = band.iscn.stop;\n\n    if (px >= pxStart && px <= pxStop) {\n      bp = getBp(iscnStop, iscnStart, px, pxStop, pxStart, band, iscnLength);\n      return bp;\n    }\n  }\n  throwPxToBpError(px, chr, pxStop);\n}\n\nexport {convertBpToPx, convertPxToBp};\n","let array8 = arrayUntyped,\n    array16 = arrayUntyped,\n    array32 = arrayUntyped,\n    arrayLengthen = arrayLengthenUntyped,\n    arrayWiden = arrayWidenUntyped;\nif (typeof Uint8Array !== \"undefined\") {\n  array8 = function(n) { return new Uint8Array(n); };\n  array16 = function(n) { return new Uint16Array(n); };\n  array32 = function(n) { return new Uint32Array(n); };\n\n  arrayLengthen = function(array, length) {\n    if (array.length >= length) return array;\n    var copy = new array.constructor(length);\n    copy.set(array);\n    return copy;\n  };\n\n  arrayWiden = function(array, width) {\n    var copy;\n    switch (width) {\n      case 16: copy = array16(array.length); break;\n      case 32: copy = array32(array.length); break;\n      default: throw new Error(\"invalid array width!\");\n    }\n    copy.set(array);\n    return copy;\n  };\n}\n\nfunction arrayUntyped(n) {\n  var array = new Array(n), i = -1;\n  while (++i < n) array[i] = 0;\n  return array;\n}\n\nfunction arrayLengthenUntyped(array, length) {\n  var n = array.length;\n  while (n < length) array[n++] = 0;\n  return array;\n}\n\nfunction arrayWidenUntyped(array, width) {\n  if (width > 32) throw new Error(\"invalid array width!\");\n  return array;\n}\n\n// An arbitrarily-wide array of bitmasks\nfunction bitarray(n) {\n  this.length = n;\n  this.subarrays = 1;\n  this.width = 8;\n  this.masks = {\n    0: 0\n  }\n\n  this[0] = array8(n);\n}\n\nbitarray.prototype.lengthen = function(n) {\n  var i, len;\n  for (i = 0, len = this.subarrays; i < len; ++i) {\n    this[i] = arrayLengthen(this[i], n);\n  }\n  this.length = n;\n};\n\n// Reserve a new bit index in the array, returns {offset, one}\nbitarray.prototype.add = function() {\n  var m, w, one, i, len;\n\n  for (i = 0, len = this.subarrays; i < len; ++i) {\n    m = this.masks[i];\n    w = this.width - (32 * i);\n    // isolate the rightmost zero bit and return it as an unsigned int of 32 bits, if NaN or -1, return a 0 \n    one = (~m & (m + 1)) >>> 0;\n\n    if (w >= 32 && !one) {\n      continue;\n    }\n\n    if (w < 32 && (one & (1 << w))) {\n      // widen this subarray\n      this[i] = arrayWiden(this[i], w <<= 1);\n      this.width = 32 * i + w;\n    }\n\n    this.masks[i] |= one;\n\n    return {\n      offset: i,\n      one: one\n    };\n  }\n\n  // add a new subarray\n  this[this.subarrays] = array8(this.length);\n  this.masks[this.subarrays] = 1;\n  this.width += 8;\n  return {\n    offset: this.subarrays++,\n    one: 1\n  };\n};\n\n// Copy record from index src to index dest\nbitarray.prototype.copy = function(dest, src) {\n  var i, len;\n  for (i = 0, len = this.subarrays; i < len; ++i) {\n    this[i][dest] = this[i][src];\n  }\n};\n\n// Truncate the array to the given length\nbitarray.prototype.truncate = function(n) {\n  var i, len;\n  for (i = 0, len = this.subarrays; i < len; ++i) {\n    for (var j = this.length - 1; j >= n; j--) {\n      this[i][j] = 0;\n    }\n  }\n  this.length = n;\n};\n\n// Checks that all bits for the given index are 0\nbitarray.prototype.zero = function(n) {\n  var i, len;\n  for (i = 0, len = this.subarrays; i < len; ++i) {\n    if (this[i][n]) {\n      return false;\n    }\n  }\n  return true;\n};\n\n// Checks that all bits for the given index are 0 except for possibly one\nbitarray.prototype.zeroExcept = function(n, offset, zero) {\n  var i, len;\n  for (i = 0, len = this.subarrays; i < len; ++i) {\n    if (i === offset ? this[i][n] & zero : this[i][n]) {\n      return false;\n    }\n  }\n  return true;\n};\n\n// Checks that all bits for the given index are 0 except for the specified mask.\n// The mask should be an array of the same size as the filter subarrays width.\nbitarray.prototype.zeroExceptMask = function(n, mask) {\n  var i, len;\n  for (i = 0, len = this.subarrays; i < len; ++i) {\n    if (this[i][n] & mask[i]) {\n      return false;\n    }\n  }\n  return true;\n}\n\n// Checks that only the specified bit is set for the given index\nbitarray.prototype.only = function(n, offset, one) {\n  var i, len;\n  for (i = 0, len = this.subarrays; i < len; ++i) {\n    if (this[i][n] != (i === offset ? one : 0)) {\n      return false;\n    }\n  }\n  return true;\n};\n\n// Checks that only the specified bit is set for the given index except for possibly one other\nbitarray.prototype.onlyExcept = function(n, offset, zero, onlyOffset, onlyOne) {\n  var mask;\n  var i, len;\n  for (i = 0, len = this.subarrays; i < len; ++i) {\n    mask = this[i][n];\n    if (i === offset)\n      mask &= zero;\n    if (mask != (i === onlyOffset ? onlyOne : 0)) {\n      return false;\n    }\n  }\n  return true;\n};\n\nexport default {\n  array8: arrayUntyped,\n  array16: arrayUntyped,\n  array32: arrayUntyped,\n  arrayLengthen: arrayLengthenUntyped,\n  arrayWiden: arrayWidenUntyped,\n  bitarray: bitarray\n};\n","const filterExact = (bisect, value) => {\n  return function(values) {\n    var n = values.length;\n    return [bisect.left(values, value, 0, n), bisect.right(values, value, 0, n)];\n  };\n}\n\nconst filterRange = (bisect, range) => {\n  var min = range[0],\n      max = range[1];\n  return function(values) {\n    var n = values.length;\n    return [bisect.left(values, min, 0, n), bisect.left(values, max, 0, n)];\n  };\n}\n\nconst filterAll = values => {\n  return [0, values.length];\n}\n\nexport default {\n  filterExact,\n  filterRange,\n  filterAll\n};\n","export default d => {\n  return d;\n};\n","export default () =>  {\n  return null;\n}\n","export default () => {\n  return 0;\n}\n","import identity from './identity';\n\nfunction heap_by(f) {\n\n  // Builds a binary heap within the specified array a[lo:hi]. The heap has the\n  // property such that the parent a[lo+i] is always less than or equal to its\n  // two children: a[lo+2*i+1] and a[lo+2*i+2].\n  function heap(a, lo, hi) {\n    var n = hi - lo,\n        i = (n >>> 1) + 1;\n    while (--i > 0) sift(a, i, n, lo);\n    return a;\n  }\n\n  // Sorts the specified array a[lo:hi] in descending order, assuming it is\n  // already a heap.\n  function sort(a, lo, hi) {\n    var n = hi - lo,\n        t;\n    while (--n > 0) t = a[lo], a[lo] = a[lo + n], a[lo + n] = t, sift(a, 1, n, lo);\n    return a;\n  }\n\n  // Sifts the element a[lo+i-1] down the heap, where the heap is the contiguous\n  // slice of array a[lo:lo+n]. This method can also be used to update the heap\n  // incrementally, without incurring the full cost of reconstructing the heap.\n  function sift(a, i, n, lo) {\n    var d = a[--lo + i],\n        x = f(d),\n        child;\n    while ((child = i << 1) <= n) {\n      if (child < n && f(a[lo + child]) > f(a[lo + child + 1])) child++;\n      if (x <= f(a[lo + child])) break;\n      a[lo + i] = a[lo + child];\n      i = child;\n    }\n    a[lo + i] = d;\n  }\n\n  heap.sort = sort;\n  return heap;\n}\n\nconst h = heap_by(identity);\nh.by = heap_by;\n\nexport default h;\n","import identity from './identity';\nimport xFilterHeap from './heap';\n\nfunction heapselect_by(f) {\n  var heap = xFilterHeap.by(f);\n\n  // Returns a new array containing the top k elements in the array a[lo:hi].\n  // The returned array is not sorted, but maintains the heap property. If k is\n  // greater than hi - lo, then fewer than k elements will be returned. The\n  // order of elements in a is unchanged by this operation.\n  function heapselect(a, lo, hi, k) {\n    var queue = new Array(k = Math.min(hi - lo, k)),\n        min,\n        i,\n        d;\n\n    for (i = 0; i < k; ++i) queue[i] = a[lo++];\n    heap(queue, 0, k);\n\n    if (lo < hi) {\n      min = f(queue[0]);\n      do {\n        if (f(d = a[lo]) > min) {\n          queue[0] = d;\n          min = f(heap(queue, 0, k)[0]);\n        }\n      } while (++lo < hi);\n    }\n\n    return queue;\n  }\n\n  return heapselect;\n}\n\n\nconst h = heapselect_by(identity);\nh.by = heapselect_by; // assign the raw function to the export as well\n\nexport default h;\n","import identity from './identity';\n\nfunction bisect_by(f) {\n\n  // Locate the insertion point for x in a to maintain sorted order. The\n  // arguments lo and hi may be used to specify a subset of the array which\n  // should be considered; by default the entire array is used. If x is already\n  // present in a, the insertion point will be before (to the left of) any\n  // existing entries. The return value is suitable for use as the first\n  // argument to `array.splice` assuming that a is already sorted.\n  //\n  // The returned insertion point i partitions the array a into two halves so\n  // that all v < x for v in a[lo:i] for the left side and all v >= x for v in\n  // a[i:hi] for the right side.\n  function bisectLeft(a, x, lo, hi) {\n    while (lo < hi) {\n      var mid = lo + hi >>> 1;\n      if (f(a[mid]) < x) lo = mid + 1;\n      else hi = mid;\n    }\n    return lo;\n  }\n\n  // Similar to bisectLeft, but returns an insertion point which comes after (to\n  // the right of) any existing entries of x in a.\n  //\n  // The returned insertion point i partitions the array into two halves so that\n  // all v <= x for v in a[lo:i] for the left side and all v > x for v in\n  // a[i:hi] for the right side.\n  function bisectRight(a, x, lo, hi) {\n    while (lo < hi) {\n      var mid = lo + hi >>> 1;\n      if (x < f(a[mid])) hi = mid;\n      else lo = mid + 1;\n    }\n    return lo;\n  }\n\n  bisectRight.right = bisectRight;\n  bisectRight.left = bisectLeft;\n  return bisectRight;\n}\n\nconst bisect = bisect_by(identity);\nbisect.by = bisect_by; // assign the raw function to the export as well\n\nexport default bisect;\n\n","export default (array, index, deep) => {\n  for (var i = 0, n = index.length, copy = deep ? JSON.parse(JSON.stringify(array)) : new Array(n); i < n; ++i) {\n    copy[i] = array[index[i]];\n  }\n  return copy;\n}\n","const reduceIncrement = p => {\n  return p + 1;\n}\n\nconst reduceDecrement = p => {\n  return p - 1;\n}\n\nconst reduceAdd = f => {\n  return function(p, v) {\n    return p + +f(v);\n  };\n}\n\nconst reduceSubtract = f => {\n  return function(p, v) {\n    return p - f(v);\n  };\n}\n\nexport default {\n  reduceIncrement,\n  reduceDecrement,\n  reduceAdd,\n  reduceSubtract\n};\n","import deep from \"@ranfdev/deepobj\"\n// Note(cg): result was previsouly using lodash.result, not ESM compatible.\n \nconst get = (obj, prop) => {\n  const value = obj[prop];\n  return (typeof value === 'function') ? value.call(obj) : value;\n}\n\n/**\n * get value of object at a deep path.\n * if the resolved value is a function,\n * it's invoked with the `this` binding of \n * its parent object and its result is returned. \n *  \n * @param  {Object} obj  the object (e.g. { 'a': [{ 'b': { 'c1': 3, 'c2': 4} }], 'd': {e:1} }; )\n * @param  {String} path deep path (e.g. `d.e`` or `a[0].b.c1`. Dot notation (a.0.b)is also supported)\n * @return {Any}      the resolved value\n */\nconst reg = /\\[([\\w\\d]+)\\]/g;\nexport default (obj, path) => {\n  return deep(get, obj, path.replace(reg, '.$1'))\n}\n","export default function(t,e,i,n,r){for(r in n=(i=i.split(\".\")).splice(-1,1),i)e=e[i[r]]=e[i[r]]||{};return t(e,n)};\n//# sourceMappingURL=deepobj.m.js.map\n","import xfilterArray from './array';\nimport xfilterFilter from './filter';\nimport cr_identity from './identity';\nimport cr_null from './null';\nimport cr_zero from './zero';\nimport xfilterHeapselect from './heapselect';\nimport xfilterHeap from './heap';\nimport bisect from './bisect';\nimport permute from './permute';\nimport xfilterReduce from './reduce';\nimport result from './result';\n\n// constants\nvar REMOVED_INDEX = -1;\n\ncrossfilter.heap = xfilterHeap;\ncrossfilter.heapselect = xfilterHeapselect;\ncrossfilter.bisect = bisect;\ncrossfilter.permute = permute;\nexport default crossfilter;\n\nfunction crossfilter() {\n  var crossfilter = {\n    add: add,\n    remove: removeData,\n    dimension: dimension,\n    groupAll: groupAll,\n    size: size,\n    all: all,\n    allFiltered: allFiltered,\n    onChange: onChange,\n    isElementFiltered: isElementFiltered\n  };\n\n  var data = [], // the records\n      n = 0, // the number of records; data.length\n      filters, // 1 is filtered out\n      filterListeners = [], // when the filters change\n      dataListeners = [], // when data is added\n      removeDataListeners = [], // when data is removed\n      callbacks = [];\n\n  filters = new xfilterArray.bitarray(0);\n\n  // Adds the specified new records to this crossfilter.\n  function add(newData) {\n    var n0 = n,\n        n1 = newData.length;\n\n    // If there's actually new data to add…\n    // Merge the new data into the existing data.\n    // Lengthen the filter bitset to handle the new records.\n    // Notify listeners (dimensions and groups) that new data is available.\n    if (n1) {\n      data = data.concat(newData);\n      filters.lengthen(n += n1);\n      dataListeners.forEach(function(l) { l(newData, n0, n1); });\n      triggerOnChange('dataAdded');\n    }\n\n    return crossfilter;\n  }\n\n  // Removes all records that match the current filters, or if a predicate function is passed,\n  // removes all records matching the predicate (ignoring filters).\n  function removeData(predicate) {\n    var // Mapping from old record indexes to new indexes (after records removed)\n        newIndex = new Array(n),\n        removed = [],\n        usePred = typeof predicate === 'function',\n        shouldRemove = function (i) {\n          return usePred ? predicate(data[i], i) : filters.zero(i)\n        };\n\n    for (var index1 = 0, index2 = 0; index1 < n; ++index1) {\n      if ( shouldRemove(index1) ) {\n        removed.push(index1);\n        newIndex[index1] = REMOVED_INDEX;\n      } else {\n        newIndex[index1] = index2++;\n      }\n    }\n\n    // Remove all matching records from groups.\n    filterListeners.forEach(function(l) { l(-1, -1, [], removed, true); });\n\n    // Update indexes.\n    removeDataListeners.forEach(function(l) { l(newIndex); });\n\n    // Remove old filters and data by overwriting.\n    for (var index3 = 0, index4 = 0; index3 < n; ++index3) {\n      if ( newIndex[index3] !== REMOVED_INDEX ) {\n        if (index3 !== index4) filters.copy(index4, index3), data[index4] = data[index3];\n        ++index4;\n      }\n    }\n\n    data.length = n = index4;\n    filters.truncate(index4);\n    triggerOnChange('dataRemoved');\n  }\n\n  function maskForDimensions(dimensions) {\n    var n,\n        d,\n        len,\n        id,\n        mask = Array(filters.subarrays);\n    for (n = 0; n < filters.subarrays; n++) { mask[n] = ~0; }\n    for (d = 0, len = dimensions.length; d < len; d++) {\n      // The top bits of the ID are the subarray offset and the lower bits are the bit\n      // offset of the \"one\" mask.\n      id = dimensions[d].id();\n      mask[id >> 7] &= ~(0x1 << (id & 0x3f));\n    }\n    return mask;\n  }\n\n  // Return true if the data element at index i is filtered IN.\n  // Optionally, ignore the filters of any dimensions in the ignore_dimensions list.\n  function isElementFiltered(i, ignore_dimensions) {\n    var mask = maskForDimensions(ignore_dimensions || []);\n    return filters.zeroExceptMask(i,mask);\n  }\n\n  // Adds a new dimension with the specified value accessor function.\n  function dimension(value, iterable) {\n\n    if (typeof value === 'string') {\n      var accessorPath = value;\n      value = function(d) { return result(d, accessorPath); };\n    }\n\n    var dimension = {\n      filter: filter,\n      filterExact: filterExact,\n      filterRange: filterRange,\n      filterFunction: filterFunction,\n      filterAll: filterAll,\n      currentFilter: currentFilter,\n      hasCurrentFilter: hasCurrentFilter,\n      top: top,\n      bottom: bottom,\n      group: group,\n      groupAll: groupAll,\n      dispose: dispose,\n      remove: dispose, // for backwards-compatibility\n      accessor: value,\n      id: function() { return id; }\n    };\n\n    var one, // lowest unset bit as mask, e.g., 00001000\n        zero, // inverted one, e.g., 11110111\n        offset, // offset into the filters arrays\n        id, // unique ID for this dimension (reused when dimensions are disposed)\n        values, // sorted, cached array\n        index, // maps sorted value index -> record index (in data)\n        newValues, // temporary array storing newly-added values\n        newIndex, // temporary array storing newly-added index\n        iterablesIndexCount,\n        iterablesIndexFilterStatus,\n        iterablesEmptyRows = [],\n        sortRange = function(n) {\n          return cr_range(n).sort(function(A, B) {\n            var a = newValues[A], b = newValues[B];\n            return a < b ? -1 : a > b ? 1 : A - B;\n          });\n        },\n        refilter = xfilterFilter.filterAll, // for recomputing filter\n        refilterFunction, // the custom filter function in use\n        filterValue, // the value used for filtering (value, array, function or undefined)\n        filterValuePresent, // true if filterValue contains something\n        indexListeners = [], // when data is added\n        dimensionGroups = [],\n        lo0 = 0,\n        hi0 = 0,\n        t = 0,\n        k;\n\n    // Updating a dimension is a two-stage process. First, we must update the\n    // associated filters for the newly-added records. Once all dimensions have\n    // updated their filters, the groups are notified to update.\n    dataListeners.unshift(preAdd);\n    dataListeners.push(postAdd);\n\n    removeDataListeners.push(removeData);\n\n    // Add a new dimension in the filter bitmap and store the offset and bitmask.\n    var tmp = filters.add();\n    offset = tmp.offset;\n    one = tmp.one;\n    zero = ~one;\n\n    // Create a unique ID for the dimension\n    // IDs will be re-used if dimensions are disposed.\n    // For internal use the ID is the subarray offset shifted left 7 bits or'd with the\n    // bit offset of the set bit in the dimension's \"one\" mask.\n    id = (offset << 7) | (Math.log(one) / Math.log(2));\n\n    preAdd(data, 0, n);\n    postAdd(data, 0, n);\n\n    // Incorporates the specified new records into this dimension.\n    // This function is responsible for updating filters, values, and index.\n    function preAdd(newData, n0, n1) {\n      var newIterablesIndexCount,\n          newIterablesIndexFilterStatus;\n\n      if (iterable){\n        // Count all the values\n        t = 0;\n        j = 0;\n        k = [];\n\n        for (var i0 = 0; i0 < newData.length; i0++) {\n          for(j = 0, k = value(newData[i0]); j < k.length; j++) {\n            t++;\n          }\n        }\n\n        newValues = [];\n        newIterablesIndexCount = cr_range(newData.length);\n        newIterablesIndexFilterStatus = cr_index(t,1);\n        var unsortedIndex = cr_range(t);\n\n        for (var l = 0, index1 = 0; index1 < newData.length; index1++) {\n          k = value(newData[index1])\n          //\n          if(!k.length){\n            newIterablesIndexCount[index1] = 0;\n            iterablesEmptyRows.push(index1 + n0);\n            continue;\n          }\n          newIterablesIndexCount[index1] = k.length\n          for (j = 0; j < k.length; j++) {\n            newValues.push(k[j]);\n            unsortedIndex[l] = index1;\n            l++;\n          }\n        }\n\n        // Create the Sort map used to sort both the values and the valueToData indices\n        var sortMap = sortRange(t);\n\n        // Use the sortMap to sort the newValues\n        newValues = permute(newValues, sortMap);\n\n\n        // Use the sortMap to sort the unsortedIndex map\n        // newIndex should be a map of sortedValue -> crossfilterData\n        newIndex = permute(unsortedIndex, sortMap)\n\n      } else{\n        // Permute new values into natural order using a standard sorted index.\n        newValues = newData.map(value);\n        newIndex = sortRange(n1);\n        newValues = permute(newValues, newIndex);\n      }\n\n      // Bisect newValues to determine which new records are selected.\n      var bounds = refilter(newValues), lo1 = bounds[0], hi1 = bounds[1];\n\n      var index2, index3, index4;\n      if(iterable) {\n        n1 = t;\n        if (refilterFunction) {\n          for (index2 = 0; index2 < n1; ++index2) {\n            if (!refilterFunction(newValues[index2], index2)) {\n              if(--newIterablesIndexCount[newIndex[index2]] === 0) {\n                filters[offset][newIndex[index2] + n0] |= one;\n              }\n              newIterablesIndexFilterStatus[index2] = 1;\n            }\n          }\n        } else {\n          for (index3 = 0; index3 < lo1; ++index3) {\n            if(--newIterablesIndexCount[newIndex[index3]] === 0) {\n              filters[offset][newIndex[index3] + n0] |= one;\n            }\n            newIterablesIndexFilterStatus[index3] = 1;\n          }\n          for (index4 = hi1; index4 < n1; ++index4) {\n            if(--newIterablesIndexCount[newIndex[index4]] === 0) {\n              filters[offset][newIndex[index4] + n0] |= one;\n            }\n            newIterablesIndexFilterStatus[index4] = 1;\n          }\n        }\n      } else {\n        if (refilterFunction) {\n          for (index2 = 0; index2 < n1; ++index2) {\n            if (!refilterFunction(newValues[index2], index2)) {\n              filters[offset][newIndex[index2] + n0] |= one;\n            }\n          }\n        } else {\n          for (index3 = 0; index3 < lo1; ++index3) {\n            filters[offset][newIndex[index3] + n0] |= one;\n          }\n          for (index4 = hi1; index4 < n1; ++index4) {\n            filters[offset][newIndex[index4] + n0] |= one;\n          }\n        }\n      }\n\n      // If this dimension previously had no data, then we don't need to do the\n      // more expensive merge operation; use the new values and index as-is.\n      if (!n0) {\n        values = newValues;\n        index = newIndex;\n        iterablesIndexCount = newIterablesIndexCount;\n        iterablesIndexFilterStatus = newIterablesIndexFilterStatus;\n        lo0 = lo1;\n        hi0 = hi1;\n        return;\n      }\n\n\n\n      var oldValues = values,\n        oldIndex = index,\n        oldIterablesIndexFilterStatus = iterablesIndexFilterStatus,\n        old_n0,\n        i1 = 0;\n\n      i0 = 0;\n\n      if(iterable){\n        old_n0 = n0\n        n0 = oldValues.length;\n        n1 = t\n      }\n\n      // Otherwise, create new arrays into which to merge new and old.\n      values = iterable ? new Array(n0 + n1) : new Array(n);\n      index = iterable ? new Array(n0 + n1) : cr_index(n, n);\n      if(iterable) iterablesIndexFilterStatus = cr_index(n0 + n1, 1);\n\n      // Concatenate the newIterablesIndexCount onto the old one.\n      if(iterable) {\n        var oldiiclength = iterablesIndexCount.length;\n        iterablesIndexCount = xfilterArray.arrayLengthen(iterablesIndexCount, n);\n        for(var j=0; j+oldiiclength < n; j++) {\n          iterablesIndexCount[j+oldiiclength] = newIterablesIndexCount[j];\n        }\n      }\n\n      // Merge the old and new sorted values, and old and new index.\n      var index5 = 0;\n      for (; i0 < n0 && i1 < n1; ++index5) {\n        if (oldValues[i0] < newValues[i1]) {\n          values[index5] = oldValues[i0];\n          if(iterable) iterablesIndexFilterStatus[index5] = oldIterablesIndexFilterStatus[i0];\n          index[index5] = oldIndex[i0++];\n        } else {\n          values[index5] = newValues[i1];\n          if(iterable) iterablesIndexFilterStatus[index5] = newIterablesIndexFilterStatus[i1];\n          index[index5] = newIndex[i1++] + (iterable ? old_n0 : n0);\n        }\n      }\n\n      // Add any remaining old values.\n      for (; i0 < n0; ++i0, ++index5) {\n        values[index5] = oldValues[i0];\n        if(iterable) iterablesIndexFilterStatus[index5] = oldIterablesIndexFilterStatus[i0];\n        index[index5] = oldIndex[i0];\n      }\n\n      // Add any remaining new values.\n      for (; i1 < n1; ++i1, ++index5) {\n        values[index5] = newValues[i1];\n        if(iterable) iterablesIndexFilterStatus[index5] = newIterablesIndexFilterStatus[i1];\n        index[index5] = newIndex[i1] + (iterable ? old_n0 : n0);\n      }\n\n      // Bisect again to recompute lo0 and hi0.\n      bounds = refilter(values), lo0 = bounds[0], hi0 = bounds[1];\n    }\n\n    // When all filters have updated, notify index listeners of the new values.\n    function postAdd(newData, n0, n1) {\n      indexListeners.forEach(function(l) { l(newValues, newIndex, n0, n1); });\n      newValues = newIndex = null;\n    }\n\n    function removeData(reIndex) {\n      if (iterable) {\n        for (var i0 = 0, i1 = 0; i0 < iterablesEmptyRows.length; i0++) {\n          if (reIndex[iterablesEmptyRows[i0]] !== REMOVED_INDEX) {\n            iterablesEmptyRows[i1] = reIndex[iterablesEmptyRows[i0]];\n            i1++;\n          }\n        }\n        iterablesEmptyRows.length = i1;\n        for (i0 = 0, i1 = 0; i0 < n; i0++) {\n          if (reIndex[i0] !== REMOVED_INDEX) {\n            if (i1 !== i0) iterablesIndexCount[i1] = iterablesIndexCount[i0];\n            i1++;\n          }\n        }\n        iterablesIndexCount = iterablesIndexCount.slice(0, i1);\n      }\n      // Rewrite our index, overwriting removed values\n      var n0 = values.length;\n      for (var i = 0, j = 0, oldDataIndex; i < n0; ++i) {\n        oldDataIndex = index[i];\n        if (reIndex[oldDataIndex] !== REMOVED_INDEX) {\n          if (i !== j) values[j] = values[i];\n          index[j] = reIndex[oldDataIndex];\n          if (iterable) {\n            iterablesIndexFilterStatus[j] = iterablesIndexFilterStatus[i];\n          }\n          ++j;\n        }\n      }\n      values.length = j;\n      if (iterable) iterablesIndexFilterStatus = iterablesIndexFilterStatus.slice(0, j);\n      while (j < n0) index[j++] = 0;\n\n      // Bisect again to recompute lo0 and hi0.\n      var bounds = refilter(values);\n      lo0 = bounds[0], hi0 = bounds[1];\n    }\n\n    // Updates the selected values based on the specified bounds [lo, hi].\n    // This implementation is used by all the public filter methods.\n    function filterIndexBounds(bounds) {\n\n      var lo1 = bounds[0],\n          hi1 = bounds[1];\n\n      if (refilterFunction) {\n        refilterFunction = null;\n        filterIndexFunction(function(d, i) { return lo1 <= i && i < hi1; }, bounds[0] === 0 && bounds[1] === values.length);\n        lo0 = lo1;\n        hi0 = hi1;\n        return dimension;\n      }\n\n      var i,\n          j,\n          k,\n          added = [],\n          removed = [],\n          valueIndexAdded = [],\n          valueIndexRemoved = [];\n\n\n      // Fast incremental update based on previous lo index.\n      if (lo1 < lo0) {\n        for (i = lo1, j = Math.min(lo0, hi1); i < j; ++i) {\n          added.push(index[i]);\n          valueIndexAdded.push(i);\n        }\n      } else if (lo1 > lo0) {\n        for (i = lo0, j = Math.min(lo1, hi0); i < j; ++i) {\n          removed.push(index[i]);\n          valueIndexRemoved.push(i);\n        }\n      }\n\n      // Fast incremental update based on previous hi index.\n      if (hi1 > hi0) {\n        for (i = Math.max(lo1, hi0), j = hi1; i < j; ++i) {\n          added.push(index[i]);\n          valueIndexAdded.push(i);\n        }\n      } else if (hi1 < hi0) {\n        for (i = Math.max(lo0, hi1), j = hi0; i < j; ++i) {\n          removed.push(index[i]);\n          valueIndexRemoved.push(i);\n        }\n      }\n\n      if(!iterable) {\n        // Flip filters normally.\n\n        for(i=0; i<added.length; i++) {\n          filters[offset][added[i]] ^= one;\n        }\n\n        for(i=0; i<removed.length; i++) {\n          filters[offset][removed[i]] ^= one;\n        }\n\n      } else {\n        // For iterables, we need to figure out if the row has been completely removed vs partially included\n        // Only count a row as added if it is not already being aggregated. Only count a row\n        // as removed if the last element being aggregated is removed.\n\n        var newAdded = [];\n        var newRemoved = [];\n        for (i = 0; i < added.length; i++) {\n          iterablesIndexCount[added[i]]++\n          iterablesIndexFilterStatus[valueIndexAdded[i]] = 0;\n          if(iterablesIndexCount[added[i]] === 1) {\n            filters[offset][added[i]] ^= one;\n            newAdded.push(added[i]);\n          }\n        }\n        for (i = 0; i < removed.length; i++) {\n          iterablesIndexCount[removed[i]]--\n          iterablesIndexFilterStatus[valueIndexRemoved[i]] = 1;\n          if(iterablesIndexCount[removed[i]] === 0) {\n            filters[offset][removed[i]] ^= one;\n            newRemoved.push(removed[i]);\n          }\n        }\n\n        added = newAdded;\n        removed = newRemoved;\n\n        // Now handle empty rows.\n        if(refilter === xfilterFilter.filterAll) {\n          for(i = 0; i < iterablesEmptyRows.length; i++) {\n            if((filters[offset][k = iterablesEmptyRows[i]] & one)) {\n              // Was not in the filter, so set the filter and add\n              filters[offset][k] ^= one;\n              added.push(k);\n            }\n          }\n        } else {\n          // filter in place - remove empty rows if necessary\n          for(i = 0; i < iterablesEmptyRows.length; i++) {\n            if(!(filters[offset][k = iterablesEmptyRows[i]] & one)) {\n              // Was in the filter, so set the filter and remove\n              filters[offset][k] ^= one;\n              removed.push(k);\n            }\n          }\n        }\n      }\n\n      lo0 = lo1;\n      hi0 = hi1;\n      filterListeners.forEach(function(l) { l(one, offset, added, removed); });\n      triggerOnChange('filtered');\n      return dimension;\n    }\n\n    // Filters this dimension using the specified range, value, or null.\n    // If the range is null, this is equivalent to filterAll.\n    // If the range is an array, this is equivalent to filterRange.\n    // Otherwise, this is equivalent to filterExact.\n    function filter(range) {\n      return range == null\n          ? filterAll() : Array.isArray(range)\n          ? filterRange(range) : typeof range === \"function\"\n          ? filterFunction(range)\n          : filterExact(range);\n    }\n\n    // Filters this dimension to select the exact value.\n    function filterExact(value) {\n      filterValue = value;\n      filterValuePresent = true;\n      return filterIndexBounds((refilter = xfilterFilter.filterExact(bisect, value))(values));\n    }\n\n    // Filters this dimension to select the specified range [lo, hi].\n    // The lower bound is inclusive, and the upper bound is exclusive.\n    function filterRange(range) {\n      filterValue = range;\n      filterValuePresent = true;\n      return filterIndexBounds((refilter = xfilterFilter.filterRange(bisect, range))(values));\n    }\n\n    // Clears any filters on this dimension.\n    function filterAll() {\n      filterValue = undefined;\n      filterValuePresent = false;\n      return filterIndexBounds((refilter = xfilterFilter.filterAll)(values));\n    }\n\n    // Filters this dimension using an arbitrary function.\n    function filterFunction(f) {\n      filterValue = f;\n      filterValuePresent = true;\n      \n      refilterFunction = f;\n      refilter = xfilterFilter.filterAll;\n\n      filterIndexFunction(f, false);\n\n      var bounds = refilter(values);\n      lo0 = bounds[0], hi0 = bounds[1];\n\n      return dimension;\n    }\n\n    function filterIndexFunction(f, filterAll) {\n      var i,\n          k,\n          x,\n          added = [],\n          removed = [],\n          valueIndexAdded = [],\n          valueIndexRemoved = [],\n          indexLength = values.length;\n\n      if(!iterable) {\n        for (i = 0; i < indexLength; ++i) {\n          if (!(filters[offset][k = index[i]] & one) ^ !!(x = f(values[i], i))) {\n            if (x) added.push(k);\n            else removed.push(k);\n          }\n        }\n      }\n\n      if(iterable) {\n        for(i=0; i < indexLength; ++i) {\n          if(f(values[i], i)) {\n            added.push(index[i]);\n            valueIndexAdded.push(i);\n          } else {\n            removed.push(index[i]);\n            valueIndexRemoved.push(i);\n          }\n        }\n      }\n\n      if(!iterable) {\n        for(i=0; i<added.length; i++) {\n          if(filters[offset][added[i]] & one) filters[offset][added[i]] &= zero;\n        }\n\n        for(i=0; i<removed.length; i++) {\n          if(!(filters[offset][removed[i]] & one)) filters[offset][removed[i]] |= one;\n        }\n      } else {\n\n        var newAdded = [];\n        var newRemoved = [];\n        for (i = 0; i < added.length; i++) {\n          // First check this particular value needs to be added\n          if(iterablesIndexFilterStatus[valueIndexAdded[i]] === 1) {\n            iterablesIndexCount[added[i]]++\n            iterablesIndexFilterStatus[valueIndexAdded[i]] = 0;\n            if(iterablesIndexCount[added[i]] === 1) {\n              filters[offset][added[i]] ^= one;\n              newAdded.push(added[i]);\n            }\n          }\n        }\n        for (i = 0; i < removed.length; i++) {\n          // First check this particular value needs to be removed\n          if(iterablesIndexFilterStatus[valueIndexRemoved[i]] === 0) {\n            iterablesIndexCount[removed[i]]--\n            iterablesIndexFilterStatus[valueIndexRemoved[i]] = 1;\n            if(iterablesIndexCount[removed[i]] === 0) {\n              filters[offset][removed[i]] ^= one;\n              newRemoved.push(removed[i]);\n            }\n          }\n        }\n\n        added = newAdded;\n        removed = newRemoved;\n\n        // Now handle empty rows.\n        if(filterAll) {\n          for(i = 0; i < iterablesEmptyRows.length; i++) {\n            if((filters[offset][k = iterablesEmptyRows[i]] & one)) {\n              // Was not in the filter, so set the filter and add\n              filters[offset][k] ^= one;\n              added.push(k);\n            }\n          }\n        } else {\n          // filter in place - remove empty rows if necessary\n          for(i = 0; i < iterablesEmptyRows.length; i++) {\n            if(!(filters[offset][k = iterablesEmptyRows[i]] & one)) {\n              // Was in the filter, so set the filter and remove\n              filters[offset][k] ^= one;\n              removed.push(k);\n            }\n          }\n        }\n      }\n\n      filterListeners.forEach(function(l) { l(one, offset, added, removed); });\n      triggerOnChange('filtered');\n    }\n    \n    function currentFilter() {\n      return filterValue;\n    }\n    \n    function hasCurrentFilter() {\n      return filterValuePresent;\n    }\n\n    // Returns the top K selected records based on this dimension's order.\n    // Note: observes this dimension's filter, unlike group and groupAll.\n    function top(k, top_offset) {\n      var array = [],\n          i = hi0,\n          j,\n          toSkip = 0;\n\n      if(top_offset && top_offset > 0) toSkip = top_offset;\n\n      while (--i >= lo0 && k > 0) {\n        if (filters.zero(j = index[i])) {\n          if(toSkip > 0) {\n            //skip matching row\n            --toSkip;\n          } else {\n            array.push(data[j]);\n            --k;\n          }\n        }\n      }\n\n      if(iterable){\n        for(i = 0; i < iterablesEmptyRows.length && k > 0; i++) {\n          // Add row with empty iterable column at the end\n          if(filters.zero(j = iterablesEmptyRows[i])) {\n            if(toSkip > 0) {\n              //skip matching row\n              --toSkip;\n            } else {\n              array.push(data[j]);\n              --k;\n            }\n          }\n        }\n      }\n\n      return array;\n    }\n\n    // Returns the bottom K selected records based on this dimension's order.\n    // Note: observes this dimension's filter, unlike group and groupAll.\n    function bottom(k, bottom_offset) {\n      var array = [],\n          i,\n          j,\n          toSkip = 0;\n\n      if(bottom_offset && bottom_offset > 0) toSkip = bottom_offset;\n\n      if(iterable) {\n        // Add row with empty iterable column at the top\n        for(i = 0; i < iterablesEmptyRows.length && k > 0; i++) {\n          if(filters.zero(j = iterablesEmptyRows[i])) {\n            if(toSkip > 0) {\n              //skip matching row\n              --toSkip;\n            } else {\n              array.push(data[j]);\n              --k;\n            }\n          }\n        }\n      }\n\n      i = lo0;\n\n      while (i < hi0 && k > 0) {\n        if (filters.zero(j = index[i])) {\n          if(toSkip > 0) {\n            //skip matching row\n            --toSkip;\n          } else {\n            array.push(data[j]);\n            --k;\n          }\n        }\n        i++;\n      }\n\n      return array;\n    }\n\n    // Adds a new group to this dimension, using the specified key function.\n    function group(key) {\n      var group = {\n        top: top,\n        all: all,\n        reduce: reduce,\n        reduceCount: reduceCount,\n        reduceSum: reduceSum,\n        order: order,\n        orderNatural: orderNatural,\n        size: size,\n        dispose: dispose,\n        remove: dispose // for backwards-compatibility\n      };\n\n      // Ensure that this group will be removed when the dimension is removed.\n      dimensionGroups.push(group);\n\n      var groups, // array of {key, value}\n          groupIndex, // object id ↦ group id\n          groupWidth = 8,\n          groupCapacity = capacity(groupWidth),\n          k = 0, // cardinality\n          select,\n          heap,\n          reduceAdd,\n          reduceRemove,\n          reduceInitial,\n          update = cr_null,\n          reset = cr_null,\n          resetNeeded = true,\n          groupAll = key === cr_null,\n          n0old;\n\n      if (arguments.length < 1) key = cr_identity;\n\n      // The group listens to the crossfilter for when any dimension changes, so\n      // that it can update the associated reduce values. It must also listen to\n      // the parent dimension for when data is added, and compute new keys.\n      filterListeners.push(update);\n      indexListeners.push(add);\n      removeDataListeners.push(removeData);\n\n      // Incorporate any existing data into the grouping.\n      add(values, index, 0, n);\n\n      // Incorporates the specified new values into this group.\n      // This function is responsible for updating groups and groupIndex.\n      function add(newValues, newIndex, n0, n1) {\n\n        if(iterable) {\n          n0old = n0\n          n0 = values.length - newValues.length\n          n1 = newValues.length;\n        }\n\n        var oldGroups = groups,\n            reIndex = iterable ? [] : cr_index(k, groupCapacity),\n            add = reduceAdd,\n            remove = reduceRemove,\n            initial = reduceInitial,\n            k0 = k, // old cardinality\n            i0 = 0, // index of old group\n            i1 = 0, // index of new record\n            j, // object id\n            g0, // old group\n            x0, // old key\n            x1, // new key\n            g, // group to add\n            x; // key of group to add\n\n        // If a reset is needed, we don't need to update the reduce values.\n        if (resetNeeded) add = initial = cr_null;\n        if (resetNeeded) remove = initial = cr_null;\n\n        // Reset the new groups (k is a lower bound).\n        // Also, make sure that groupIndex exists and is long enough.\n        groups = new Array(k), k = 0;\n        if(iterable){\n          groupIndex = k0 ? groupIndex : [];\n        }\n        else{\n          groupIndex = k0 > 1 ? xfilterArray.arrayLengthen(groupIndex, n) : cr_index(n, groupCapacity);\n        }\n\n\n        // Get the first old key (x0 of g0), if it exists.\n        if (k0) x0 = (g0 = oldGroups[0]).key;\n\n        // Find the first new key (x1), skipping NaN keys.\n        while (i1 < n1 && !((x1 = key(newValues[i1])) >= x1)) ++i1;\n\n        // While new keys remain…\n        while (i1 < n1) {\n\n          // Determine the lesser of the two current keys; new and old.\n          // If there are no old keys remaining, then always add the new key.\n          if (g0 && x0 <= x1) {\n            g = g0, x = x0;\n\n            // Record the new index of the old group.\n            reIndex[i0] = k;\n\n            // Retrieve the next old key.\n            g0 = oldGroups[++i0];\n            if (g0) x0 = g0.key;\n          } else {\n            g = {key: x1, value: initial()}, x = x1;\n          }\n\n          // Add the lesser group.\n          groups[k] = g;\n\n          // Add any selected records belonging to the added group, while\n          // advancing the new key and populating the associated group index.\n\n          while (x1 <= x) {\n            j = newIndex[i1] + (iterable ? n0old : n0)\n\n\n            if(iterable){\n              if(groupIndex[j]){\n                groupIndex[j].push(k)\n              }\n              else{\n                groupIndex[j] = [k]\n              }\n            }\n            else{\n              groupIndex[j] = k;\n            }\n\n            // Always add new values to groups. Only remove when not in filter.\n            // This gives groups full information on data life-cycle.\n            g.value = add(g.value, data[j], true);\n            if (!filters.zeroExcept(j, offset, zero)) g.value = remove(g.value, data[j], false);\n            if (++i1 >= n1) break;\n            x1 = key(newValues[i1]);\n          }\n\n          groupIncrement();\n        }\n\n        // Add any remaining old groups that were greater th1an all new keys.\n        // No incremental reduce is needed; these groups have no new records.\n        // Also record the new index of the old group.\n        while (i0 < k0) {\n          groups[reIndex[i0] = k] = oldGroups[i0++];\n          groupIncrement();\n        }\n\n\n        // Fill in gaps with empty arrays where there may have been rows with empty iterables\n        if(iterable){\n          for (var index1 = 0; index1 < n; index1++) {\n            if(!groupIndex[index1]){\n              groupIndex[index1] = [];\n            }\n          }\n        }\n\n        // If we added any new groups before any old groups,\n        // update the group index of all the old records.\n        if(k > i0){\n          if(iterable){\n            for (i0 = 0; i0 < n0old; ++i0) {\n              for (index1 = 0; index1 < groupIndex[i0].length; index1++) {\n                groupIndex[i0][index1] = reIndex[groupIndex[i0][index1]];\n              }\n            }\n          }\n          else{\n            for (i0 = 0; i0 < n0; ++i0) {\n              groupIndex[i0] = reIndex[groupIndex[i0]];\n            }\n          }\n        }\n\n        // Modify the update and reset behavior based on the cardinality.\n        // If the cardinality is less than or equal to one, then the groupIndex\n        // is not needed. If the cardinality is zero, then there are no records\n        // and therefore no groups to update or reset. Note that we also must\n        // change the registered listener to point to the new method.\n        j = filterListeners.indexOf(update);\n        if (k > 1 || iterable) {\n          update = updateMany;\n          reset = resetMany;\n        } else {\n          if (!k && groupAll) {\n            k = 1;\n            groups = [{key: null, value: initial()}];\n          }\n          if (k === 1) {\n            update = updateOne;\n            reset = resetOne;\n          } else {\n            update = cr_null;\n            reset = cr_null;\n          }\n          groupIndex = null;\n        }\n        filterListeners[j] = update;\n\n        // Count the number of added groups,\n        // and widen the group index as needed.\n        function groupIncrement() {\n          if(iterable){\n            k++\n            return\n          }\n          if (++k === groupCapacity) {\n            reIndex = xfilterArray.arrayWiden(reIndex, groupWidth <<= 1);\n            groupIndex = xfilterArray.arrayWiden(groupIndex, groupWidth);\n            groupCapacity = capacity(groupWidth);\n          }\n        }\n      }\n\n      function removeData(reIndex) {\n        if (k > 1 || iterable) {\n          var oldK = k,\n              oldGroups = groups,\n              seenGroups = cr_index(oldK, oldK),\n              i,\n              i0,\n              j;\n\n          // Filter out non-matches by copying matching group index entries to\n          // the beginning of the array.\n          if (!iterable) {\n            for (i = 0, j = 0; i < n; ++i) {\n              if (reIndex[i] !== REMOVED_INDEX) {\n                seenGroups[groupIndex[j] = groupIndex[i]] = 1;\n                ++j;\n              }\n            }\n          } else {\n            for (i = 0, j = 0; i < n; ++i) {\n              if (reIndex[i] !== REMOVED_INDEX) {\n                groupIndex[j] = groupIndex[i];\n                for (i0 = 0; i0 < groupIndex[j].length; i0++) {\n                  seenGroups[groupIndex[j][i0]] = 1;\n                }\n                ++j;\n              }\n            }\n          }\n\n          // Reassemble groups including only those groups that were referred\n          // to by matching group index entries.  Note the new group index in\n          // seenGroups.\n          groups = [], k = 0;\n          for (i = 0; i < oldK; ++i) {\n            if (seenGroups[i]) {\n              seenGroups[i] = k++;\n              groups.push(oldGroups[i]);\n            }\n          }\n\n          if (k > 1 || iterable) {\n            // Reindex the group index using seenGroups to find the new index.\n            if (!iterable) {\n              for (i = 0; i < j; ++i) groupIndex[i] = seenGroups[groupIndex[i]];\n            } else {\n              for (i = 0; i < j; ++i) {\n                for (i0 = 0; i0 < groupIndex[i].length; ++i0) {\n                  groupIndex[i][i0] = seenGroups[groupIndex[i][i0]];\n                }\n              }\n            }\n          } else {\n            groupIndex = null;\n          }\n          filterListeners[filterListeners.indexOf(update)] = k > 1 || iterable\n              ? (reset = resetMany, update = updateMany)\n              : k === 1 ? (reset = resetOne, update = updateOne)\n              : reset = update = cr_null;\n        } else if (k === 1) {\n          if (groupAll) return;\n          for (var index3 = 0; index3 < n; ++index3) if (reIndex[index3] !== REMOVED_INDEX) return;\n          groups = [], k = 0;\n          filterListeners[filterListeners.indexOf(update)] =\n          update = reset = cr_null;\n        }\n      }\n\n      // Reduces the specified selected or deselected records.\n      // This function is only used when the cardinality is greater than 1.\n      // notFilter indicates a crossfilter.add/remove operation.\n      function updateMany(filterOne, filterOffset, added, removed, notFilter) {\n\n        if ((filterOne === one && filterOffset === offset) || resetNeeded) return;\n\n        var i,\n            j,\n            k,\n            n,\n            g;\n\n        if(iterable){\n          // Add the added values.\n          for (i = 0, n = added.length; i < n; ++i) {\n            if (filters.zeroExcept(k = added[i], offset, zero)) {\n              for (j = 0; j < groupIndex[k].length; j++) {\n                g = groups[groupIndex[k][j]];\n                g.value = reduceAdd(g.value, data[k], false, j);\n              }\n            }\n          }\n\n          // Remove the removed values.\n          for (i = 0, n = removed.length; i < n; ++i) {\n            if (filters.onlyExcept(k = removed[i], offset, zero, filterOffset, filterOne)) {\n              for (j = 0; j < groupIndex[k].length; j++) {\n                g = groups[groupIndex[k][j]];\n                g.value = reduceRemove(g.value, data[k], notFilter, j);\n              }\n            }\n          }\n          return;\n        }\n\n        // Add the added values.\n        for (i = 0, n = added.length; i < n; ++i) {\n          if (filters.zeroExcept(k = added[i], offset, zero)) {\n            g = groups[groupIndex[k]];\n            g.value = reduceAdd(g.value, data[k], false);\n          }\n        }\n\n        // Remove the removed values.\n        for (i = 0, n = removed.length; i < n; ++i) {\n          if (filters.onlyExcept(k = removed[i], offset, zero, filterOffset, filterOne)) {\n            g = groups[groupIndex[k]];\n            g.value = reduceRemove(g.value, data[k], notFilter);\n          }\n        }\n      }\n\n      // Reduces the specified selected or deselected records.\n      // This function is only used when the cardinality is 1.\n      // notFilter indicates a crossfilter.add/remove operation.\n      function updateOne(filterOne, filterOffset, added, removed, notFilter) {\n        if ((filterOne === one && filterOffset === offset) || resetNeeded) return;\n\n        var i,\n            k,\n            n,\n            g = groups[0];\n\n        // Add the added values.\n        for (i = 0, n = added.length; i < n; ++i) {\n          if (filters.zeroExcept(k = added[i], offset, zero)) {\n            g.value = reduceAdd(g.value, data[k], false);\n          }\n        }\n\n        // Remove the removed values.\n        for (i = 0, n = removed.length; i < n; ++i) {\n          if (filters.onlyExcept(k = removed[i], offset, zero, filterOffset, filterOne)) {\n            g.value = reduceRemove(g.value, data[k], notFilter);\n          }\n        }\n      }\n\n      // Recomputes the group reduce values from scratch.\n      // This function is only used when the cardinality is greater than 1.\n      function resetMany() {\n        var i,\n            j,\n            g;\n\n        // Reset all group values.\n        for (i = 0; i < k; ++i) {\n          groups[i].value = reduceInitial();\n        }\n\n        // We add all records and then remove filtered records so that reducers\n        // can build an 'unfiltered' view even if there are already filters in\n        // place on other dimensions.\n        if(iterable){\n          for (i = 0; i < n; ++i) {\n            for (j = 0; j < groupIndex[i].length; j++) {\n              g = groups[groupIndex[i][j]];\n              g.value = reduceAdd(g.value, data[i], true, j);\n            }\n          }\n          for (i = 0; i < n; ++i) {\n            if (!filters.zeroExcept(i, offset, zero)) {\n              for (j = 0; j < groupIndex[i].length; j++) {\n                g = groups[groupIndex[i][j]];\n                g.value = reduceRemove(g.value, data[i], false, j);\n              }\n            }\n          }\n          return;\n        }\n\n        for (i = 0; i < n; ++i) {\n          g = groups[groupIndex[i]];\n          g.value = reduceAdd(g.value, data[i], true);\n        }\n        for (i = 0; i < n; ++i) {\n          if (!filters.zeroExcept(i, offset, zero)) {\n            g = groups[groupIndex[i]];\n            g.value = reduceRemove(g.value, data[i], false);\n          }\n        }\n      }\n\n      // Recomputes the group reduce values from scratch.\n      // This function is only used when the cardinality is 1.\n      function resetOne() {\n        var i,\n            g = groups[0];\n\n        // Reset the singleton group values.\n        g.value = reduceInitial();\n\n        // We add all records and then remove filtered records so that reducers\n        // can build an 'unfiltered' view even if there are already filters in\n        // place on other dimensions.\n        for (i = 0; i < n; ++i) {\n          g.value = reduceAdd(g.value, data[i], true);\n        }\n\n        for (i = 0; i < n; ++i) {\n          if (!filters.zeroExcept(i, offset, zero)) {\n            g.value = reduceRemove(g.value, data[i], false);\n          }\n        }\n      }\n\n      // Returns the array of group values, in the dimension's natural order.\n      function all() {\n        if (resetNeeded) reset(), resetNeeded = false;\n        return groups;\n      }\n\n      // Returns a new array containing the top K group values, in reduce order.\n      function top(k) {\n        var top = select(all(), 0, groups.length, k);\n        return heap.sort(top, 0, top.length);\n      }\n\n      // Sets the reduce behavior for this group to use the specified functions.\n      // This method lazily recomputes the reduce values, waiting until needed.\n      function reduce(add, remove, initial) {\n        reduceAdd = add;\n        reduceRemove = remove;\n        reduceInitial = initial;\n        resetNeeded = true;\n        return group;\n      }\n\n      // A convenience method for reducing by count.\n      function reduceCount() {\n        return reduce(xfilterReduce.reduceIncrement, xfilterReduce.reduceDecrement, cr_zero);\n      }\n\n      // A convenience method for reducing by sum(value).\n      function reduceSum(value) {\n        return reduce(xfilterReduce.reduceAdd(value), xfilterReduce.reduceSubtract(value), cr_zero);\n      }\n\n      // Sets the reduce order, using the specified accessor.\n      function order(value) {\n        select = xfilterHeapselect.by(valueOf);\n        heap = xfilterHeap.by(valueOf);\n        function valueOf(d) { return value(d.value); }\n        return group;\n      }\n\n      // A convenience method for natural ordering by reduce value.\n      function orderNatural() {\n        return order(cr_identity);\n      }\n\n      // Returns the cardinality of this group, irrespective of any filters.\n      function size() {\n        return k;\n      }\n\n      // Removes this group and associated event listeners.\n      function dispose() {\n        var i = filterListeners.indexOf(update);\n        if (i >= 0) filterListeners.splice(i, 1);\n        i = indexListeners.indexOf(add);\n        if (i >= 0) indexListeners.splice(i, 1);\n        i = removeDataListeners.indexOf(removeData);\n        if (i >= 0) removeDataListeners.splice(i, 1);\n        i = dimensionGroups.indexOf(group);\n        if (i >= 0) dimensionGroups.splice(i, 1);\n        return group;\n      }\n\n      return reduceCount().orderNatural();\n    }\n\n    // A convenience function for generating a singleton group.\n    function groupAll() {\n      var g = group(cr_null), all = g.all;\n      delete g.all;\n      delete g.top;\n      delete g.order;\n      delete g.orderNatural;\n      delete g.size;\n      g.value = function() { return all()[0].value; };\n      return g;\n    }\n\n    // Removes this dimension and associated groups and event listeners.\n    function dispose() {\n      dimensionGroups.forEach(function(group) { group.dispose(); });\n      var i = dataListeners.indexOf(preAdd);\n      if (i >= 0) dataListeners.splice(i, 1);\n      i = dataListeners.indexOf(postAdd);\n      if (i >= 0) dataListeners.splice(i, 1);\n      i = removeDataListeners.indexOf(removeData);\n      if (i >= 0) removeDataListeners.splice(i, 1);\n      filters.masks[offset] &= zero;\n      return filterAll();\n    }\n\n    return dimension;\n  }\n\n  // A convenience method for groupAll on a dummy dimension.\n  // This implementation can be optimized since it always has cardinality 1.\n  function groupAll() {\n    var group = {\n      reduce: reduce,\n      reduceCount: reduceCount,\n      reduceSum: reduceSum,\n      value: value,\n      dispose: dispose,\n      remove: dispose // for backwards-compatibility\n    };\n\n    var reduceValue,\n        reduceAdd,\n        reduceRemove,\n        reduceInitial,\n        resetNeeded = true;\n\n    // The group listens to the crossfilter for when any dimension changes, so\n    // that it can update the reduce value. It must also listen to the parent\n    // dimension for when data is added.\n    filterListeners.push(update);\n    dataListeners.push(add);\n\n    // For consistency; actually a no-op since resetNeeded is true.\n    add(data, 0, n);\n\n    // Incorporates the specified new values into this group.\n    function add(newData, n0) {\n      var i;\n\n      if (resetNeeded) return;\n\n      // Cycle through all the values.\n      for (i = n0; i < n; ++i) {\n\n        // Add all values all the time.\n        reduceValue = reduceAdd(reduceValue, data[i], true);\n\n        // Remove the value if filtered.\n        if (!filters.zero(i)) {\n          reduceValue = reduceRemove(reduceValue, data[i], false);\n        }\n      }\n    }\n\n    // Reduces the specified selected or deselected records.\n    function update(filterOne, filterOffset, added, removed, notFilter) {\n      var i,\n          k,\n          n;\n\n      if (resetNeeded) return;\n\n      // Add the added values.\n      for (i = 0, n = added.length; i < n; ++i) {\n        if (filters.zero(k = added[i])) {\n          reduceValue = reduceAdd(reduceValue, data[k], notFilter);\n        }\n      }\n\n      // Remove the removed values.\n      for (i = 0, n = removed.length; i < n; ++i) {\n        if (filters.only(k = removed[i], filterOffset, filterOne)) {\n          reduceValue = reduceRemove(reduceValue, data[k], notFilter);\n        }\n      }\n    }\n\n    // Recomputes the group reduce value from scratch.\n    function reset() {\n      var i;\n\n      reduceValue = reduceInitial();\n\n      // Cycle through all the values.\n      for (i = 0; i < n; ++i) {\n\n        // Add all values all the time.\n        reduceValue = reduceAdd(reduceValue, data[i], true);\n\n        // Remove the value if it is filtered.\n        if (!filters.zero(i)) {\n          reduceValue = reduceRemove(reduceValue, data[i], false);\n        }\n      }\n    }\n\n    // Sets the reduce behavior for this group to use the specified functions.\n    // This method lazily recomputes the reduce value, waiting until needed.\n    function reduce(add, remove, initial) {\n      reduceAdd = add;\n      reduceRemove = remove;\n      reduceInitial = initial;\n      resetNeeded = true;\n      return group;\n    }\n\n    // A convenience method for reducing by count.\n    function reduceCount() {\n      return reduce(xfilterReduce.reduceIncrement, xfilterReduce.reduceDecrement, cr_zero);\n    }\n\n    // A convenience method for reducing by sum(value).\n    function reduceSum(value) {\n      return reduce(xfilterReduce.reduceAdd(value), xfilterReduce.reduceSubtract(value), cr_zero);\n    }\n\n    // Returns the computed reduce value.\n    function value() {\n      if (resetNeeded) reset(), resetNeeded = false;\n      return reduceValue;\n    }\n\n    // Removes this group and associated event listeners.\n    function dispose() {\n      var i = filterListeners.indexOf(update);\n      if (i >= 0) filterListeners.splice(i, 1);\n      i = dataListeners.indexOf(add);\n      if (i >= 0) dataListeners.splice(i, 1);\n      return group;\n    }\n\n    return reduceCount();\n  }\n\n  // Returns the number of records in this crossfilter, irrespective of any filters.\n  function size() {\n    return n;\n  }\n\n  // Returns the raw row data contained in this crossfilter\n  function all(){\n    return data;\n  }\n\n  // Returns row data with all dimension filters applied, except for filters in ignore_dimensions\n  function allFiltered(ignore_dimensions) {\n    var array = [],\n        i = 0,\n        mask = maskForDimensions(ignore_dimensions || []);\n\n      for (i = 0; i < n; i++) {\n        if (filters.zeroExceptMask(i, mask)) {\n          array.push(data[i]);\n        }\n      }\n\n      return array;\n  }\n\n  function onChange(cb){\n    if(typeof cb !== 'function'){\n      /* eslint no-console: 0 */\n      console.warn('onChange callback parameter must be a function!');\n      return;\n    }\n    callbacks.push(cb);\n    return function(){\n      callbacks.splice(callbacks.indexOf(cb), 1);\n    };\n  }\n\n  function triggerOnChange(eventName){\n    for (var i = 0; i < callbacks.length; i++) {\n      callbacks[i](eventName);\n    }\n  }\n\n  return arguments.length\n      ? add(arguments[0])\n      : crossfilter;\n}\n\n// Returns an array of size n, big enough to store ids up to m.\nfunction cr_index(n, m) {\n  return (m < 0x101\n      ? xfilterArray.array8 : m < 0x10001\n      ? xfilterArray.array16\n      : xfilterArray.array32)(n);\n}\n\n// Constructs a new array of size n, with sequential values from 0 to n - 1.\nfunction cr_range(n) {\n  var range = cr_index(n, n);\n  for (var i = -1; ++i < n;) range[i] = i;\n  return range;\n}\n\nfunction capacity(w) {\n  return w === 8\n      ? 0x100 : w === 16\n      ? 0x10000\n      : 0x100000000;\n}\n","import {d3} from './lib';\nimport crossfilter from 'crossfilter2';\n\n/* Decompresses ideogram's annotations for crossfilter initialization\nBy default, annotations are clustered by chromosome, e.g.\n[\n  {\"chr\": \"1\", \"annots\": [{\"from\": 100, \"to\", 101, \"chr\": \"1\", ...}, ...]},\n  {\"chr\": \"2\", \"annots\": [{\"from\": 500, \"to\", 501, \"chr\": \"2\", ...}, ...]},\n  ...\n]\nThis method flattens that structure to e.g.\n[\n  {\"from\": 100, \"to\": 101, \"chr\": \"1\", ...},\n  ...\n  {\"from\": 500, \"to\": 501, \"chr\": \"2\", ...},\n]\nSee also: packAnnots\n*/\nfunction unpackAnnots() {\n  var chr, annots, i,\n    unpackedAnnots = [],\n    ideo = this,\n    chrs = ideo.annots;\n\n  for (i = 0; i < chrs.length; i++) {\n    chr = chrs[i];\n    annots = chr.annots;\n    unpackedAnnots = unpackedAnnots.concat(annots);\n  }\n\n  return unpackedAnnots;\n}\n\n/*\n  Compresses annots back to default state.  Inverse of unpackAnnots.\n*/\nfunction packAnnots(unpackedAnnots) {\n  var chr, annot, i,\n    annots = [],\n    ideo = this,\n    chrs = ideo.annots;\n\n  for (chr in chrs) {\n    annots.push({chr: chrs[chr].chr, annots: []});\n  }\n\n  for (i = 0; i < unpackedAnnots.length; i++) {\n    annot = unpackedAnnots[i];\n    annots[annot.chrIndex].annots.push(annot);\n  }\n\n  return annots;\n}\n\n/*\n  Initializes crossfilter.  Needed for client-side filtering.\n  More: https://github.com/square/crossfilter/wiki/API-Reference\n*/\nfunction initCrossFilter() {\n  var i, facet,\n    ideo = this,\n    keys = ideo.rawAnnots.keys;\n\n  ideo.unpackedAnnots = ideo.unpackAnnots();\n  ideo.crossfilter = crossfilter(ideo.unpackedAnnots);\n\n  ideo.annotsByFacet = {};\n  ideo.facets = keys.slice(3, keys.length);\n\n  for (i = 0; i < ideo.facets.length; i++) {\n    facet = ideo.facets[i];\n    ideo.annotsByFacet[facet] =\n      ideo.crossfilter.dimension(function(d) {\n        return d[facet];\n      });\n  }\n\n  if ('filterSelections' in ideo) {\n    ideo.filterAnnots(ideo.filterSelections);\n  }\n\n  ideo.filteredAnnots = ideo.annots;\n}\n\nfunction getFilteredResults(selections, ideo) {\n  var fn, i, facet, results, filter,\n    counts = {};\n\n  if (Object.keys(selections).length === 0) {\n    results = ideo.unpackedAnnots;\n  } else {\n    for (i = 0; i < ideo.facets.length; i++) {\n      facet = ideo.facets[i];\n      if (facet in selections) {\n        filter = selections[facet];\n        if (Array.isArray(filter)) {\n          fn = function(d) {\n            // Filter is numeric range\n            if (filter.length === 2) {\n              // [min, max]\n              return filter[0] <= d && d < filter[1];\n            } else if (filter.length === 4) {\n              // [min1, max1, min2, max2]\n              return (\n                filter[0] <= d && d < filter[1] ||\n                filter[2] <= d && d < filter[3]\n              );\n            }\n          };\n        } else {\n          fn = function(d) {\n            // Filter is set of categories\n            return (d in filter);\n          };\n        }\n      } else {\n        fn = null;\n      }\n      ideo.annotsByFacet[facet].filter(fn);\n      counts[facet] = ideo.annotsByFacet[facet].group().top(Infinity);\n    }\n    results = ideo.annotsByFacet[facet].top(Infinity);\n  }\n\n  return [results, counts];\n}\n\n/*\n  Filters annotations based on the given selections.\n  \"selections\" is an object of objects, e.g.\n\n    {\n      \"tissue-type\": {          <-- a facet\n        \"cerebral-cortex\": 1,   <-- a filter; \"1\" means it is selected\n        \"liver\": 1\n      },\n      \"gene-type\": {\n        mirna\": 1\n      }\n    }\n\n  Translation:\n  select where:\n      (tissue-type is cerebral-cortex OR liver) and (gene-type is mirna)\n\n  TODO:\n    * Filter counts\n    * Integrate server-side filtering for very large datasets\n*/\nfunction filterAnnots(selections) {\n  var i, facet, results, counts,\n    t0 = Date.now(),\n    ideo = this;\n\n  ideo.filterSelections = selections;\n  [results, counts] = getFilteredResults(selections, ideo);\n\n  for (i < 0; i < ideo.facets.length; i++) {\n    ideo.annotsByFacet[facet].filterAll(); // clear filters\n  }\n\n  results = ideo.packAnnots(results);\n\n  delete ideo.maxAnnotsPerBar;\n  delete ideo.maxAnnotsPerBarAllChrs;\n\n  ideo.filteredAnnots = results;\n\n  d3.selectAll(ideo.selector + ' polygon.annot').remove();\n  ideo.drawAnnots(results);\n\n  console.log('Time in filterAnnots: ' + (Date.now() - t0) + ' ms');\n\n  return counts;\n}\n\nexport {unpackAnnots, packAnnots, initCrossFilter, filterAnnots};\n","function getPixelAndOtherData(bands, chr, hasBands, ideo) {\n  var i, band, csLength, width, maxLength,\n    pxStop = 0,\n    taxid = chr.id.split('-')[1],\n    cs = ideo.coordinateSystem,\n    chrHeight = ideo.config.chrHeight;\n\n  for (i = 0; i < bands.length; i++) {\n    band = bands[i];\n    csLength = band[cs].stop - band[cs].start;\n\n    // If ideogram is rotated (and thus showing only one chromosome),\n    // then set its width independent of the longest chromosome in this\n    // genome.\n    if (ideo._layout._isRotated) {\n      width = chrHeight * csLength / chr.length;\n    } else {\n      if (ideo.config.chromosomeScale === 'relative') {\n        maxLength = ideo.maxLength[taxid][cs];\n      } else {\n        maxLength = ideo.maxLength[cs];\n      }\n      width = chrHeight * chr.length / maxLength * csLength / chr.length;\n    }\n    bands[i].px = {start: pxStop, stop: pxStop + width, width: width};\n\n    pxStop = bands[i].px.stop;\n\n    if (hasBands && band.stain === 'acen' && band.name[0] === 'p') {\n      chr.pcenIndex = i;\n    }\n  }\n  return [bands, chr, pxStop];\n}\n\n/**\n * TODO:\n * A chromosome-level scale property is likely\n * nonsensical for any chromosomes that have cytogenetic band data.\n * Different bands tend to have ratios between number of base pairs\n * and physical length.\n *\n * However, a chromosome-level scale property is likely\n * necessary for chromosomes that do not have band data.\n *\n * This needs further review.\n */\nfunction getChrScale(chr, hasBands, ideo) {\n  var chrHeight = ideo.config.chrHeight,\n    chrLength = chr.length,\n    maxLength = ideo.maxLength,\n    taxid = chr.id.split('-')[1],\n    scale = {};\n\n  scale.bp = chrHeight / maxLength.bp;\n\n  if (ideo.config.multiorganism === true) {\n    // chr.scale.bp = band.iscn.stop / band.bp.stop;\n    if (ideo.config.chromosomeScale === 'relative') {\n      scale.iscn = chrHeight * chrLength / maxLength[taxid].bp;\n      scale.bp = chrHeight / maxLength[taxid].bp;\n    } else {\n      scale.iscn = chrHeight * chrLength / maxLength.bp;\n    }\n  } else if (hasBands) {\n    scale.iscn = chrHeight / maxLength.iscn;\n  }\n\n  return scale;\n}\n\nfunction getChromosomePixels(chr) {\n  var bands, chrHeight, pxStop, hasBands, maxLength,\n    taxid = chr.id.split('-')[1],\n    ideo = this;\n\n  bands = chr.bands;\n  chrHeight = ideo.config.chrHeight;\n  pxStop = 0;\n  hasBands = (typeof bands !== 'undefined');\n\n  if (hasBands) {\n    [bands, chr, pxStop] = getPixelAndOtherData(bands, chr, hasBands, ideo);\n  } else {\n    if (ideo.config.chromosomeScale === 'relative') {\n      maxLength = ideo.maxLength[taxid][ideo.coordinateSystem];\n    } else {\n      maxLength = ideo.maxLength[ideo.coordinateSystem];\n    }\n    pxStop = chrHeight * chr.length / maxLength;\n  }\n\n  chr.width = pxStop;\n  chr.scale = getChrScale(chr, hasBands, ideo);\n  chr.bands = bands;\n\n  return chr;\n}\n\nfunction getChrModelScaffold(chr, bands, chrName, ideo) {\n  var hasBands = (typeof bands !== 'undefined');\n\n  if (hasBands) {\n    const lastBand = bands[bands.length - 1];\n    chr.name = chrName;\n    chr.length = lastBand[ideo.coordinateSystem].stop;\n\n    // Accounts for case where this chromosome\n    chr.bpLength = lastBand.bp.stop;\n\n    chr.type = 'nuclear';\n  } else {\n    chr = chrName;\n  }\n\n  return chr;\n}\n\n/**\n * Encountered when processing an assembly that has chromosomes with\n * centromere data, but this chromosome does not.\n * Example: chromosome F1 in Felis catus.\n */\nfunction deleteExtraneousBands(chr, hasBands) {\n  if (hasBands && chr.bands.length === 1) {\n    delete chr.bands;\n  }\n  return chr;\n}\n\nfunction getCentromerePosition(hasBands, bands) {\n\n  if (hasBands === false) return '';\n\n  // As with Macaca mulatta chromosome Y\n  const firstBand = bands[0];\n  const lastBand = bands.slice(-1)[0];\n  const chrLength = lastBand.bp.stop - firstBand.bp.start;\n  const smallLength = chrLength/20;\n\n  if (\n    // As with almost all mouse chromosome, chimpanzee chr22\n    firstBand.name[0] === 'p' && bands[1].name[0] === 'q' &&\n    firstBand.bp.stop - firstBand.bp.start < smallLength\n  ) {\n    return 'telocentric-p';\n  }\n\n  const penultimateBand = bands.slice(-2)[0];\n\n  if (\n    penultimateBand.name[0] === 'p' && lastBand.name[0] === 'q' &&\n    lastBand.bp.stop - lastBand.bp.start < smallLength\n  ) {\n    // As with Macaca mulatta chromosome Y\n    return 'telocentric-q';\n  }\n\n  return '';\n}\n\n/**\n * Generates a model object for each chromosome containing information on\n * its name, DOM ID, length in base pairs or ISCN coordinates, cytogenetic\n * bands, centromere position, etc.\n */\nfunction getChromosomeModel(bands, chrName, taxid, chrIndex) {\n  var hasBands, org,\n    chr = {},\n    ideo = this;\n\n  hasBands = (typeof bands !== 'undefined');\n\n  chr = getChrModelScaffold(chr, bands, chrName, ideo);\n\n  chr.chrIndex = chrIndex;\n  chr.id = 'chr' + chr.name + '-' + taxid;\n\n  if (ideo.config.fullChromosomeLabels === true) {\n    org = this.organisms[taxid];\n    chr.name = org.scientificName + ' chr' + chr.name;\n  }\n\n  chr.bands = bands;\n  chr = ideo.getChromosomePixels(chr);\n  chr.centromerePosition = getCentromerePosition(hasBands, bands);\n\n  chr = deleteExtraneousBands(chr, hasBands);\n\n  return chr;\n}\n\nexport {getChromosomeModel, getChromosomePixels};\n","// import {getSettings, handleSettingsHeaderClick} from './settings-ui';\nimport version from '../version';\nimport {downloadPng} from '../lib';\n\nconst style = `\n  <style>\n\n    #gear {\n      position: absolute;\n      right: 3px;\n      top: 24px;\n      z-index: 8001;\n      cursor: pointer;\n      height: 18px;\n      width: 18px;\n    }\n\n    #tools {\n      position: absolute;\n      width: 120px;\n      right: 27px;\n      top: 16px;\n      z-index: 8000;\n      background: white;\n      margin: 0;\n      border: 1px solid #CCC;\n      border-radius: 4px;\n      box-shadow: -2px 4px 6px #CCC;\n    }\n\n    #tools ul {\n      margin-block-start: 0;\n      margin-block-end: 0;\n      padding-inline-start: 0;\n    }\n\n    #tools li, #download li {\n      padding: 2px 12px 2px 12px;\n      cursor: pointer;\n    }\n\n    #tools li:hover,\n    #tools li.active,\n    #download li:hover {\n      background: #DDD;\n    }\n\n    #tools li.ideo-disabled,\n    #tools li.active.ideo-disabled,\n    #download li.ideo-disabled {\n      background: #FFF;\n      color: #CCC;\n      cursor: default;\n    }\n\n    #download {\n      position: absolute;\n      right: 3px;\n      top: 16px;\n      z-index: 8000;\n      background: white;\n      margin: 0;\n      padding-inline-start: 0;\n    }\n\n    #settings {\n      position: absolute;\n      right: 3px;\n      top: 16px;\n      z-index: 8000;\n      background: white;\n      margin: 0;\n      padding-inline-start: 0;\n    }\n\n    #about {\n      position: absolute;\n      right: 24px;\n      top: -8px;\n      z-index: 8000;\n      background: white;\n      width: 300px;\n      border: 1px solid #CCC;\n      padding: 10px;\n      border-radius: 4px;\n      box-shadow: -2px 4px 6px #CCC;\n      cursor: default;\n    }\n\n    #close {\n      float: right;\n      border: 1px solid #DDD;\n      border-radius: 4px;\n      padding: 0 6px;\n      background: #EEE;\n      font-weight: bold;\n      cursor: pointer;\n    }\n\n    #settings label {\n      display: inline;\n      text-decoration: underline;\n      text-decoration-style: dotted;\n      cursor: pointer;\n    }\n\n    #download {\n      position: absolute;\n      width: 120px;\n      top: -2px;\n      right: 120px;\n      z-index: 8000;\n      background: white;\n      margin: 0;\n      border: 1px solid #CCC;\n      border-radius: 4px;\n      box-shadow: -2px 4px 6px #CCC;\n    }\n\n    li {\n      list-style-type: none;\n    }\n\n    #settings .no-underline {\n      text-decoration: none;\n    }\n\n    #settings .setting {\n      margin-right: 8px;\n    }\n\n    #settings input[type=\"checkbox\"], #settings input[type=\"radio\"] {\n      position: relative;\n      top: 2px;\n    }\n\n    .area-header {\n      font-size: 16px;\n      font-weight: bold;\n      margin-bottom: 10px;\n      clear: both;\n    }\n\n    .area-content {\n      display: flex;\n      flex-wrap: wrap;\n    }\n\n    .area-content > div {\n      margin-right: 30px;\n      margin-bottom: 15px;\n    }\n\n    .tab-panel input[type=\"number\"] {\n      width: 50px;\n    }\n\n    .tab-panel ul {\n      width: 600px;\n      list-style: none;\n      border-bottom: 1px solid #CCC;\n      box-sizing: border-box;\n      margin-bottom: 0;\n      padding-left: 0;\n    }\n\n    .tab-panel .nav:before, .tab-panel .nav:after {\n      content: \" \";\n      display: table;\n      clear: both;\n    }\n\n    .tab-panel li {\n      float: left;\n      margin-right: 2px;\n      display: block;\n      margin-bottom: -1px;\n    }\n\n    .tab-panel li > a {\n      padding: 10px 15px;\n      text-decoration: none;\n      border-radius: 4px 4px 0 0;\n      display: block;\n      position: relative;\n    }\n\n    .tab-panel li.active > a {\n      border: 1px solid #CCC;\n      border-bottom: none;\n      background-color: white;\n    }\n\n    .tab-panel .tab-content {\n      width: 600px;\n    }\n\n    .tab-panel .tab-content > div {\n      display: none;\n      padding-top: 20px;\n      clear: both;\n    }\n\n    .tab-panel .tab-content > div {\n      padding: 20px 10px 5px 10px;\n    }\n\n    .tab-panel .tab-content > div.active {\n      display: block;\n      border: 1px solid #CCC;\n      border-top: none;\n    }\n\n  </style>`;\n\n// eslint-disable-next-line max-len\nconst gearIcon = '<svg viewBox=\"0 0 512 512\"><path fill=\"#AAA\" d=\"M444.788 291.1l42.616 24.599c4.867 2.809 7.126 8.618 5.459 13.985-11.07 35.642-29.97 67.842-54.689 94.586a12.016 12.016 0 0 1-14.832 2.254l-42.584-24.595a191.577 191.577 0 0 1-60.759 35.13v49.182a12.01 12.01 0 0 1-9.377 11.718c-34.956 7.85-72.499 8.256-109.219.007-5.49-1.233-9.403-6.096-9.403-11.723v-49.184a191.555 191.555 0 0 1-60.759-35.13l-42.584 24.595a12.016 12.016 0 0 1-14.832-2.254c-24.718-26.744-43.619-58.944-54.689-94.586-1.667-5.366.592-11.175 5.459-13.985L67.212 291.1a193.48 193.48 0 0 1 0-70.199l-42.616-24.599c-4.867-2.809-7.126-8.618-5.459-13.985 11.07-35.642 29.97-67.842 54.689-94.586a12.016 12.016 0 0 1 14.832-2.254l42.584 24.595a191.577 191.577 0 0 1 60.759-35.13V25.759a12.01 12.01 0 0 1 9.377-11.718c34.956-7.85 72.499-8.256 109.219-.007 5.49 1.233 9.403 6.096 9.403 11.723v49.184a191.555 191.555 0 0 1 60.759 35.13l42.584-24.595a12.016 12.016 0 0 1 14.832 2.254c24.718 26.744 43.619 58.944 54.689 94.586 1.667 5.366-.592 11.175-5.459 13.985L444.788 220.9a193.485 193.485 0 0 1 0 70.2zM336 256c0-44.112-35.888-80-80-80s-80 35.888-80 80 35.888 80 80 80 80-35.888 80-80z\"/></svg>';\n// Font Awesome Free 5.2.0 by @fontawesome - https://fontawesome.com\n// License - https://fontawesome.com/license (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License)\n\nfunction deactivate(items) {\n  items.forEach(item => {item.classList.remove('active');});\n}\n\nfunction closeTools() {\n  const toolHeaders = document.querySelectorAll('#tools > ul > li');\n  deactivate(toolHeaders);\n  const itemsToClose =\n    document.querySelectorAll('.ideo-modal, .ideo-tool-panel');\n  itemsToClose.forEach(item => {item.remove();});\n\n  document.querySelector('#tools').style.display = 'none';\n}\n\n/**\n * As needed, hide tool panels that are triggered by hovering\n */\nfunction handleHideForHoverables(trigger, tool, toolHeader, toolHeaders) {\n  if (trigger === 'mouseenter') {\n\n    // Hide panel when hover leaves tool header, if new target element\n    // is part of the tools UI (and not the panel itself)\n    toolHeader.addEventListener('mouseleave', event => {\n      const toElement = event.toElement;\n      const toId = toElement.id;\n      const panelElement = document.querySelector('.ideo-tool-panel');\n      const toolsElement = document.querySelector('#tools');\n      if (\n        toolsElement.contains(toElement) &&\n        panelElement && !panelElement.contains(toElement) &&\n        toId !== tool\n      ) {\n        deactivate(toolHeaders);\n        panelElement.remove();\n      }\n    });\n  }\n}\n\n/** Determine action that should trigger a tool panel to display */\nfunction getTrigger(toolHeader) {\n  const shouldHover =\n    Array.from(toolHeader.classList).includes('ideo-tool-hover');\n  const trigger = shouldHover ? 'mouseenter' : 'click';\n  return trigger;\n}\n\n/** Shows clicked tool as active, displays resulting panel */\nfunction handleToolClick(ideo) {\n  const toolHeaders = document.querySelectorAll('#tools > ul > li');\n\n  toolHeaders.forEach(toolHeader => {\n    const trigger = getTrigger(toolHeader);\n\n    toolHeader.addEventListener(trigger, event => {\n\n      // Show only clicked tool header as active\n      deactivate(toolHeaders);\n      toolHeader.classList += ' active';\n\n      const tool = toolHeader.id.split('-')[0];\n      const panel = getPanel(tool, ideo);\n\n      if (trigger === 'mouseenter') {\n        toolHeader.insertAdjacentHTML('beforeend', panel);\n        handleHideForHoverables(trigger, tool, toolHeader, toolHeaders);\n\n        if (tool === 'download') {\n          document.querySelector('#download-image')\n            .addEventListener('click', event => {\n              closeTools();\n              downloadPng(ideo);\n            });\n\n          document.querySelector('#download-annots')\n            .addEventListener('click', event => {\n              const element = document.querySelector('#download-annots');\n              const classes = Array.from(element.classList);\n              if (classes.includes('ideo-disabled') === false) {\n                closeTools();\n                ideo.downloadAnnotations();\n              }\n            });\n        }\n      } else {\n        document.querySelector('#gear').insertAdjacentHTML('beforeend', panel);\n      }\n    });\n  });\n\n  // Upon clicking \"close\" (x), remove tools UI\n  document.querySelectorAll('#close').forEach(closeButton => {\n    closeButton.addEventListener('click', () => {closeTools();});\n  });\n\n}\n\nfunction handleGearClick(ideo) {\n  document.querySelector('#gear')\n    .addEventListener('click', event => {\n      var options = document.querySelector('#tools');\n      if (options.style.display === 'none') {\n        options.style.display = '';\n        hideOnClickOutside();\n      } else {\n        options.style.display = 'none';\n        closeTools();\n      }\n    });\n\n  handleToolClick(ideo);\n\n  // handleSettingsHeaderClick(ideo);\n}\n\nfunction showGearOnIdeogramHover(ideo) {\n  const container = document.querySelector(ideo.selector);\n  const gear = document.querySelector('#gear');\n  const panel = document.querySelector('#tools');\n\n  container.addEventListener('mouseover', () => gear.style.display = '');\n  container.addEventListener('mouseout', () => {\n    // Hide gear only if panel is not shown\n    if (panel.style.display === 'none') {\n      gear.style.display = 'none';\n    }\n  });\n\n  gear.addEventListener('mouseover', () => gear.style.display = '');\n}\n\nfunction getPanel(tool, ideo) {\n  var panel;\n  // if (tool === 'settings') panel = getSettings();\n  if (tool === 'download') panel = getDownload(ideo);\n  if (tool === 'about') panel = getAbout();\n  return panel.trim();\n}\n\nfunction getDownload(ideo) {\n\n  const numAnnots = document.querySelectorAll('.annot').length;\n  const annotsClass = (numAnnots > 0) ? '' : 'ideo-disabled';\n\n  return `\n    <div id=\"download\" class=\"ideo-tool-panel\">\n      <li id=\"download-image\">Image</li>\n      <li id=\"download-annots\" class=\"${annotsClass}\">Annotations</li>\n    </div>\n  `;\n}\n\nfunction getAbout() {\n  const ideogramLink = `\n    <a href=\"https://github.com/eweitz/ideogram\" target=\"_blank\" rel=\"noopener\">\n      Ideogram.js</a>`;\n  const closeButton = '<span id=\"close\">x</span>';\n  return `\n    <div id=\"about\" class=\"ideo-modal\">\n      ${ideogramLink}, version ${version} ${closeButton}<br/>\n      <i>Chromosome visualization for the web</i>\n    </div>`;\n}\n\nfunction hideOnClickOutside(selector) {\n  const elements = document.querySelectorAll('#gear, #tools');\n  const outsideClickListener = event => {\n    let clickedOutsideCount = 0;\n    elements.forEach((element) => {\n      if (!element.contains(event.target)) {\n        clickedOutsideCount += 1;\n      }\n    });\n    if (clickedOutsideCount === elements.length) {\n      closeTools();\n      removeClickListener();\n    }\n  };\n\n  const removeClickListener = () => {\n    document.removeEventListener('click', outsideClickListener);\n  };\n\n  document.addEventListener('click', outsideClickListener);\n}\n\nfunction initTools(ideo) {\n\n  const triangle = '<span style=\"float: right\">&blacktriangleright;</span>';\n\n  const toolsHtml = `\n    ${style}\n    <div id=\"gear\" style=\"display: none\">${gearIcon}</div>\n    <div id=\"tools\" style=\"display: none\">\n      <ul>\n        <li id=\"download-tool\" class=\"ideo-tool-hover\">Download ${triangle}</li>\n        <li id=\"about-tool\">About</li>\n      </ul>\n    </div>`;\n\n\n  document.querySelector(ideo.selector)\n    .insertAdjacentHTML('beforebegin', toolsHtml);\n\n  handleGearClick(ideo);\n\n  showGearOnIdeogramHover(ideo);\n}\n\nexport {initTools};\n\n","/* eslint-disable no-use-before-define */\n\nexport class ModelAdapter {\n\n  constructor(model) {\n    this._model = model;\n    this._class = 'ModelAdapter';\n  }\n\n  static getInstance(model) {\n    if (model.bands) {\n      return new ModelAdapter(model);\n    } else {\n      return new ModelNoBandsAdapter(model);\n    }\n  }\n\n  getModel() {\n    return this._model;\n  }\n\n  getCssClass() {\n    return '';\n  }\n}\n\nexport class ModelNoBandsAdapter extends ModelAdapter {\n\n  constructor(model) {\n    super(model);\n    this._class = 'ModelNoBandsAdapter';\n  }\n\n  getModel() {\n    this._model.bands = [];\n\n    const isMT = this._model.name === 'MT'; // Is mitochondrial chromosome\n    const width = this._model.width;\n\n    if (width > 1 || isMT) {\n      // Add single band to bands array\n      this._model.bands.push({\n        name: 'q',\n        px: {\n          start: 0,\n          stop: width,\n          width: width\n        },\n        bp: {\n          start: 1,\n          stop: this._model.bpLength\n        },\n        iscn: {\n          start: 1,\n          stop: this._model.length\n        }\n      });\n    }\n\n    return this._model;\n  }\n\n  getCssClass() {\n    return 'noBands';\n  }\n\n}\n","import {Ploidy} from './ploidy';\n\nexport class Color {\n\n  constructor(config) {\n    // Ideogram config\n    this._config = config;\n    this._ploidy = new Ploidy(this._config);\n  }\n\n  getArmColor(chrSetIndex, chrIndex, armIndex) {\n    if (this._config.armColors) {\n      return this._config.armColors[armIndex];\n    } else if (this._config.ancestors) {\n      return this._getPolyploidArmColor(chrSetIndex, chrIndex, armIndex);\n    } else {\n      return null;\n    }\n  }\n\n  getBorderColor(chrSetIndex, chrIndex, armIndex) {\n    const config = this._config;\n    const color = config.chrBorderColor ? config.chrBorderColor : '#000';\n    if (chrIndex < config.ploidy) {\n      return color;\n    } else if (this._ploidy.exists(chrSetIndex, chrIndex, armIndex)) {\n      return color;\n    } else {\n      return '#fff';\n    }\n  }\n\n  getFillColor() {\n    const config = this._config;\n    if (!config.chrFillColor) return '#AAA';\n    const color = config.chrFillColor;\n    if (typeof color === 'string') {\n      return {arm: color, centromere: ''};\n    } else {\n      return color;\n    };\n  }\n\n  _getPolyploidArmColor(chrSetIndex, chrIndex, armIndex) {\n    if (!this._ploidy.exists(chrSetIndex, chrIndex, armIndex)) {\n      return 'transparent';\n    } else {\n      var ancestor =\n        this._ploidy.getAncestor(chrSetIndex, chrIndex, armIndex);\n      return this._config.ancestors[ancestor];\n    }\n  }\n\n}\n","export class Range {\n\n  /**\n  * Chromosome range.\n  * @public\n  * @class\n  * @param {Object} data - range data.\n  * @param {Integer} data.chr - chromosome index.\n  * @param {Integer[]} [data.ploidy] - array which controls on which\n  *                                    chromosomes range should appear in case\n  *                                    of ploidy.\n  * @param {Integer} data.start - range start.\n  * @param {Integer} data.stop - range end.\n  * @param {String} data.color - range color.\n  */\n  constructor(data) {\n    this._data = data;\n    this.start = data.start;\n    this.stop = data.stop;\n    this.length = this.stop - this.start;\n  }\n\n  getColor(chrIndex) {\n    if (!('ploidy' in this._data)) {\n      return this._getColor(chrIndex);\n    } else if ('ploidy' in this._data && this._data.ploidy[chrIndex]) {\n      return this._getColor(chrIndex);\n    } else {\n      return 'transparent';\n    }\n  }\n\n  _getColor(chrIndex) {\n    if (Array.isArray(this._data.color)) {\n      return this._data.color[chrIndex];\n    } else {\n      return this._data.color;\n    }\n  }\n\n}\n","/* eslint-disable no-use-before-define */\nimport {Color} from './../color';\nimport {Range} from './../range';\n\nexport class Chromosome {\n\n  constructor(adapter, config, ideo) {\n    this._adapter = adapter;\n    this._model = this._adapter.getModel();\n    this._config = config;\n    this._ideo = ideo;\n    this._color = new Color(this._config);\n    this._bumpCoefficient = 5;\n  }\n\n  /**\n   * Factory method\n   */\n  static getInstance(adapter, config, ideo) {\n    const centromerePosition = adapter.getModel().centromerePosition;\n    if (centromerePosition === 'telocentric-p') {\n      return new TelocentricPChromosome(adapter, config, ideo);\n    } else if (centromerePosition === 'telocentric-q') {\n      return new TelocentricQChromosome(adapter, config, ideo);\n    } else {\n      return new MetacentricChromosome(adapter, config, ideo);\n    }\n  }\n\n  _addPArmShape(clipPath, isPArmRendered) {\n    if (isPArmRendered) {\n      return clipPath.concat(this._getPArmShape());\n    } else {\n      return clipPath;\n    }\n  }\n\n  _addQArmShape(clipPath, isQArmRendered) {\n    if (isQArmRendered) {\n      return clipPath.concat(this._getQArmShape());\n    } else {\n      return clipPath;\n    }\n  }\n\n  /**\n   * Append bands container and apply clip-path to it\n   */\n  render(container, chrSetIndex, chrIndex) {\n\n    var self, isPArmRendered, isQArmRendered, clipPath, opacity, fill,\n      isFullyBanded;\n\n    self = this;\n\n    container = container.append('g')\n      .attr('class', 'bands')\n      .attr('clip-path',\n        'url(#' + this._model.id + '-chromosome-set-clippath)'\n      );\n\n    // Render chromosome arms\n    isPArmRendered = this._renderArm(container, chrSetIndex, chrIndex, 'p');\n    isQArmRendered = this._renderArm(container, chrSetIndex, chrIndex, 'q');\n\n    // Render range set\n    this._renderRangeSet(container, chrSetIndex, chrIndex);\n\n    // Push arms shape string into clipPath array\n    clipPath = [];\n    clipPath = this._addPArmShape(clipPath, isPArmRendered);\n    clipPath = this._addQArmShape(clipPath, isQArmRendered);\n\n    opacity = '0';\n    fill = '';\n    isFullyBanded = this.isFullyBanded();\n    if (\n      'ancestors' in this._ideo.config &&\n      !('rangeSet' in this._ideo.config)\n    ) {\n      // E.g. diploid human genome (with translucent overlay)\n      fill = self._color.getArmColor(chrSetIndex, chrIndex, 0);\n      if (isFullyBanded) {\n        opacity = '0.5';\n      }\n    } else if (isFullyBanded) {\n      // E.g. mouse reference genome\n      opacity = null;\n      fill = 'transparent';\n    } else if (!('ancestors' in this._ideo.config)) {\n      // E.g. chimpanzee assembly Pan_tro 3.0\n      opacity = '1';\n    }\n\n    let centromereFill;\n    if (this._ideo.config.chrFillColor) {\n      const fillColor = self._color.getFillColor();\n      fill = fillColor.arm;\n      centromereFill = fillColor.centromere;\n    }\n\n    // Render chromosome border\n    container.append('g')\n      .attr('class', 'chromosome-border')\n      .selectAll('path')\n      .data(clipPath)\n      .enter()\n      .append('path')\n      .attr('fill', fill)\n      .style('fill-opacity', opacity)\n      .style('fill', function(d) {\n        if (d.class === 'acen' && centromereFill) {\n          return centromereFill;\n        }\n      })\n      .attr('stroke', function(d, i) {\n        return self._color.getBorderColor(chrSetIndex, chrIndex, i);\n      })\n      .attr('stroke-width', function(d) {\n        return ('strokeWidth' in d ? d.strokeWidth : 1);\n      })\n      .attr('d', function(d) {\n        return d.path;\n      }).attr('class', function(d) {\n        return d.class;\n      });\n\n    return clipPath;\n  }\n\n  _renderRangeSet(container, chrSetIndex, chrIndex) {\n\n    var self, rangeSet, rangesContainer, ideo;\n\n    if (!('rangeSet' in this._config)) {\n      return;\n    }\n\n    rangeSet = this._config.rangeSet.filter(function(range) {\n      return range.chr - 1 === chrSetIndex;\n    }).map(function(range) {\n      return new Range(range);\n    });\n\n    rangesContainer = container.append('g').attr('class', 'range-set');\n\n    self = this;\n    ideo = self._ideo;\n\n    rangesContainer.selectAll('rect.range')\n      .data(rangeSet)\n      .enter()\n      .append('rect')\n      .attr('class', 'range')\n      .attr('x', function(range) {\n        return ideo.convertBpToPx(self._model, range.start);\n      }).attr('y', 0)\n      .attr('width', function(range) {\n        return ideo.convertBpToPx(self._model, range.length);\n      }).attr('height', this._config.chrWidth)\n      .style('fill', function(range) {\n        return range.getColor(chrIndex);\n      });\n  }\n\n  /**\n   * Get chromosome's shape main values\n   */\n  _getShapeData() {\n\n    var firstQBand, i, lastBand, rightTerminalPosition;\n\n    // First q band from bands sequence\n    for (i = 0; i < this._model.bands.length; i++) {\n      if (this._model.bands[i].name[0] === 'q') {\n        firstQBand = this._model.bands[i];\n        break;\n      }\n    }\n\n    // Chromosome's right position\n    lastBand = this._model.bands.length - 1;\n    rightTerminalPosition = this._model.bands[lastBand].px.stop;\n\n    // Properties description:\n    // x1 - left terminal start position\n    // x2 - centromere position\n    // x3 - right terminal end position\n    // w - chromosome width\n    // b - bump size\n    return {\n      x1: 0,\n      x2: firstQBand ? firstQBand.px.start : rightTerminalPosition,\n      x3: rightTerminalPosition,\n      w: this._config.chrWidth,\n      b: this._config.chrWidth / this._bumpCoefficient\n    };\n  }\n\n  _getPArmShape() {\n    var d = this._getShapeData(),\n      x = d.x2 - d.b;\n\n    if (this.isFullyBanded() || 'ancestors' in this._ideo.config) {\n      // Encountered when chromosome has any of:\n      //  - One placeholder \"band\", e.g. pig genome GCF_000003025.5\n      //  - Many (> 2) bands, e.g. human reference genome\n      //  - Ancestor colors in ploidy configuration, as in ploidy-basic.html\n      return {\n        class: '',\n        path:\n          'M' + d.b + ',0 ' +\n          'L' + x + ',0 ' +\n          'Q' + (d.x2 + d.b) + ',' + (d.w / 2) + ',' + x + ',' + d.w + ' ' +\n          'L' + d.b + ',' + d.w + ' ' +\n          'Q-' + d.b + ',' + (d.w / 2) + ',' + d.b + ',0'\n      };\n    } else {\n      // e.g. chimpanzee assembly Pan_tro 3.0\n      return [{\n        class: '',\n        path:\n          'M' + d.b + ',0 ' +\n          'L' + (x - 2) + ',0 ' +\n          'L' + (x - 2) + ',' + d.w + ' ' +\n          'L' + d.b + ',' + d.w + ' ' +\n          'Q-' + d.b + ',' + (d.w / 2) + ',' + d.b + ',0'\n      }, {\n        class: 'acen',\n        path:\n          'M' + x + ',0 ' +\n          'Q' + (d.x2 + d.b) + ',' + (d.w / 2) + ',' + x + ',' + d.w + ' ' +\n          'L' + x + ',' + d.w + ' ' +\n          'L' + (x - 2) + ',' + d.w + ' ' +\n          'L' + (x - 2) + ',0'\n      }];\n    }\n  }\n\n  _getQArmShape() {\n    var d = this._getShapeData(),\n      x = d.x3 - d.b,\n      x2b = d.x2 + d.b;\n\n    if (this.isFullyBanded() || 'ancestors' in this._ideo.config) {\n      return {\n        class: '',\n        path:\n          'M' + x2b + ',0 ' +\n          'L' + x + ',0 ' +\n          'Q' + (d.x3 + d.b) + ',' + (d.w / 2) + ',' + x + ',' + d.w + ' ' +\n          'L' + x2b + ',' + d.w + ' ' +\n          'Q' + (d.x2 - d.b) + ',' + (d.w / 2) + ',' + x2b + ',0'\n      };\n    } else {\n      // e.g. chimpanzee assembly Pan_tro 3.0\n      return [{\n        path:\n          'M' + x2b + ',0 ' +\n          'L' + x + ',0 ' +\n          'Q' + (d.x3 + d.b) + ',' + (d.w / 2) + ',' + x + ',' + d.w + ' ' +\n          'L' + x2b + ',' + d.w + ' ' +\n          'L' + x2b + ',0'\n      }, {\n        class: 'acen',\n        path:\n          'M' + x2b + ',0' +\n          'Q' + (d.x2 - d.b) + ',' + (d.w / 2) + ',' + x2b + ',' + d.w + ' ' +\n          'L' + x2b + ',' + d.w +\n          'L' + (x2b + 2) + ',' + d.w +\n          'L' + (x2b + 2) + ',0'\n      }];\n    }\n  }\n\n  isFullyBanded() {\n    return (\n      this._model.bands &&\n      (this._model.bands.length !== 2 || this._model.bands[0].name[0] === 'q')\n    );\n  }\n\n  /**\n   * Render arm bands\n   */\n  _renderBands(container, chrSetIndex, chrIndex, bands, arm) {\n\n    var self, armIndex, fill;\n\n    self = this;\n    armIndex = arm === 'p' ? 0 : 1;\n    fill = '';\n\n    if ('ancestors' in self._ideo.config && !(self.isFullyBanded())) {\n      fill = self._color.getArmColor(chrSetIndex, chrIndex, armIndex);\n    }\n\n    container.selectAll('path.band.' + arm)\n      .data(bands)\n      .enter()\n      .append('path')\n      .attr('id', function(d) {\n        return self._model.id + '-' + d.name.replace('.', '-');\n      })\n      .attr('class', function(d) {\n        return 'band ' + arm + '-band ' + d.stain;\n      })\n      .attr('d', function(d) {\n        var start, length;\n\n        start = self._ideo.round(d.px.start);\n        length = self._ideo.round(d.px.width);\n\n        return 'M ' + start + ', 0' +\n              'l ' + length + ' 0 ' +\n              'l 0 ' + self._config.chrWidth + ' ' +\n              'l -' + length + ' 0 z';\n      })\n      .style('fill', fill);\n  }\n\n  /**\n   * Render a chromosome arm.\n   * Returns boolean indicating if any bands were rendered.\n   */\n  _renderArm(container, chrSetIndex, chrIndex, arm) {\n    var bands = this._model.bands.filter(function(band) {\n      return band.name[0] === arm;\n    });\n\n    this._renderBands(container, chrSetIndex, chrIndex, bands, arm);\n\n    return Boolean(bands.length);\n  }\n}\n\nexport class MetacentricChromosome extends Chromosome {\n\n  constructor(model, config, ideo) {\n    super(model, config, ideo);\n    this._class = 'MetacentricChromosome';\n  }\n}\n\nexport class TelocentricPChromosome extends Chromosome {\n\n  constructor(model, config, ideo) {\n    // alert('p')\n    super(model, config, ideo);\n    this._class = 'TelocentricPChromosome';\n    this._pArmOffset = 3;\n  }\n\n  _addPArmShape(clipPath) {\n    return clipPath.concat(this._getPArmShape());\n  }\n\n  _getPArmShape() {\n    // Properties description:\n    // x1 - left terminal start position\n    // x2 - centromere position\n    // x3 - right terminal end position\n    // w - chromosome width\n    // b - bump size\n    var d = this._getShapeData();\n    d.o = this._pArmOffset;\n\n    return [{\n      class: 'acen',\n      path: 'M' + (d.x2 + 2) + ',1' +\n      'L' + (d.x2 + d.o + 3.25) + ',1 ' +\n      'L' + (d.x2 + d.o + 3.25) + ',' + (d.w - 1) + ' ' +\n      'L' + (d.x2 + 2) + ',' + (d.w - 1)\n    }, {\n      class: 'gpos66',\n      path: 'M' + (d.x2 - d.o + 5) + ',0' +\n      'L' + (d.x2 - d.o + 3) + ',0 ' +\n      'L' + (d.x2 - d.o + 3) + ',' + d.w + ' ' +\n      'L' + (d.x2 - d.o + 5) + ',' + d.w,\n      strokeWidth: 0.5\n    }];\n  }\n\n  _getQArmShape() {\n    // Properties description:\n    // x1 - left terminal start position\n    // x2 - centromere position\n    // x3 - right terminal end position\n    // w - chromosome width\n    // b - bump size\n    var d = this._getShapeData(),\n      x = d.x3 - d.b,\n      o = this._pArmOffset + 3;\n\n    return {\n      class: '',\n      path:\n      'M' + (d.x2 + o) + ',0 ' +\n      'L' + x + ',0 ' +\n      'Q' + (d.x3 + d.b) + ',' + (d.w / 2) + ',' + x + ',' + d.w + ' ' +\n      'L' + (d.x2 + o) + ',' + d.w\n    };\n  }\n}\n\nexport class TelocentricQChromosome extends Chromosome {\n\n  constructor(model, config, ideo) {\n    // alert('q')\n    super(model, config, ideo);\n    this._class = 'TelocentricQChromosome';\n    this._qArmOffset = 3;\n  }\n\n  _getPArmShape() {\n    // Properties description:\n    // x1 - left terminal start position\n    // x2 - centromere position\n    // x3 - right terminal end position\n    // w - chromosome width\n    // b - bump size\n\n    var d = this._getShapeData(),\n      x = d.x3 - d.b,\n      o = this._qArmOffset;\n\n    return {\n      class: '',\n      path:\n      // 'M1,0, ' +\n      'M' + (d.x2 + o) + ',0 ' +\n      'L' + (x + o) + ',0 ' +\n      'L' + (x + o) + ',' + d.w + ' ' +\n      'L' + d.b + ',' + d.w + ' ' +\n      'Q-' + d.b + ',' + (d.w / 2) + ',' + d.b + ',0'\n    };\n  }\n\n  _addQArmShape(clipPath) {\n    return clipPath.concat(this._getQArmShape());\n  }\n\n  _getQArmShape() {\n    // Properties description:\n    // x1 - left terminal start position\n    // x2 - centromere position\n    // x3 - right terminal end position\n    // w - chromosome width\n    // b - bump size\n    var d = this._getShapeData();\n    d.o = this._qArmOffset;\n\n    return [{\n      class: 'acen',\n      path: 'M' + (d.x2 + 2) + ',1 ' +\n      'L' + (d.x2 + d.o + 3.25) + ',1 ' +\n      'L' + (d.x2 + d.o + 3.25) + ',' + (d.w - 1) + ' ' +\n      'L' + (d.x2 + 2) + ',' + (d.w - 1)\n    }, {\n      class: 'gpos66',\n      path: 'M' + (d.x2 + d.o + 5) + ',0 ' +\n      'L' + (d.x2 + d.o + 3) + ',0 ' +\n      'L' + (d.x2 + d.o + 3) + ',' + d.w + ' ' +\n      'L' + (d.x2 + d.o + 5) + ',' + d.w,\n      strokeWidth: 0.5\n    }];\n  }\n}\n","import {d3} from '../lib';\nimport {initTools} from '../tools/tools';\nimport {ModelAdapter} from '../model-adapter';\nimport {Chromosome} from './chromosome';\n\n/**\n * Adds a copy of a chromosome (i.e. a homologous chromosome, homolog) to DOM\n *\n * @param chrModel\n * @param chrIndex\n * @param homologIndex\n * @param container\n */\nfunction appendHomolog(chrModel, chrIndex, homologIndex, container) {\n\n  var homologOffset, chromosome, shape, defs, adapter;\n\n  defs = d3.select(this.selector + ' defs');\n  // Get chromosome model adapter class\n  adapter = ModelAdapter.getInstance(chrModel);\n\n  // How far this copy of the chromosome is from another\n  homologOffset = homologIndex * this.config.chrMargin;\n\n  // Append chromosome's container\n  chromosome = container\n    .append('g')\n    .attr('id', chrModel.id)\n    .attr('class', 'chromosome ' + adapter.getCssClass())\n    .attr('transform', 'translate(0, ' + homologOffset + ')');\n\n  // Render chromosome\n  shape = Chromosome.getInstance(adapter, this.config, this)\n    .render(chromosome, chrIndex, homologIndex);\n\n  d3.select('#' + chrModel.id + '-chromosome-set-clippath').remove();\n\n  defs.append('clipPath')\n    .attr('id', chrModel.id + '-chromosome-set-clippath')\n    .selectAll('path')\n    .data(shape)\n    .enter()\n    .append('path')\n    .attr('d', function(d) {return d.path;})\n    .attr('class', function(d) {return d.class;});\n\n\n  if (chrModel.width < 1) {\n    d3.select('#' + chrModel.id + ' .bands').style('opacity', 0);\n  }\n}\n\n/**\n * Renders all the bands and outlining boundaries of a chromosome.\n */\nfunction drawChromosome(chrModel) {\n  var chrIndex, container, numChrsInSet, transform, homologIndex,\n    chrSetSelector;\n\n  chrIndex = chrModel.chrIndex;\n\n  transform = this._layout.getChromosomeSetTranslate(chrIndex);\n\n  chrSetSelector = this.selector + ' #' + chrModel.id + '-chromosome-set';\n\n  d3.selectAll(chrSetSelector + ' g').remove();\n\n  container = d3.select(chrSetSelector);\n\n  if (container.nodes().length === 0) {\n    // Append chromosome set container\n    container = d3.select(this.selector)\n      .append('g')\n      .attr('class', 'chromosome-set')\n      .attr('transform', transform)\n      .attr('id', chrModel.id + '-chromosome-set');\n  }\n\n  if (\n    'sex' in this.config &&\n    this.config.ploidy === 2 &&\n    this.sexChromosomes.index === chrIndex\n  ) {\n    this.drawSexChromosomes(container, chrIndex);\n    return;\n  }\n\n  numChrsInSet = 1;\n  if (this.config.ploidy > 1) {\n    numChrsInSet = this._ploidy.getChromosomesNumber(chrIndex);\n  }\n\n  for (homologIndex = 0; homologIndex < numChrsInSet; homologIndex++) {\n    this.appendHomolog(chrModel, chrIndex, homologIndex, container);\n  }\n}\n\n/**\n * Rotates a chromosome 90 degrees and shows or hides all other chromosomes\n * Useful for focusing or defocusing a particular chromosome\n */\nfunction rotateAndToggleDisplay(chrElement) {\n  var chrName, chrModel, chrIndex;\n\n  this.unhighlight();\n\n  // Do nothing if taxid not defined. But it should be defined.\n  // To fix that bug we should have a way to find chromosome set number.\n  if (!this.config.taxid) return;\n\n  chrName = chrElement.id.split('-')[0].replace('chr', '');\n  chrModel = this.chromosomes[this.config.taxid][chrName];\n  chrIndex = chrModel.chrIndex;\n\n  this._layout.rotate(chrIndex, chrIndex, chrElement);\n}\n\nfunction setOverflowScroll() {\n  var ideo, config, ideoWidth, ideoInnerWrap, ideoMiddleWrap, ideoSvg,\n    ploidy, ploidyPad;\n\n  ideo = this;\n  config = ideo.config;\n\n  ideoSvg = d3.select(config.container + ' svg#_ideogram');\n  ideoInnerWrap = d3.select(config.container + ' #_ideogramInnerWrap');\n  ideoMiddleWrap = d3.select(config.container + ' #_ideogramMiddleWrap');\n\n  ploidy = config.ploidy;\n  if (ploidy === 1) {\n    ploidyPad = ploidy;\n  } else {\n    ploidyPad = ploidy * 1.12;\n  }\n\n  let annotHeight = 0;\n  if ('annotationsLayout' in config) {\n    annotHeight = config.annotationHeight * config.numAnnotTracks;\n  }\n\n  if (\n    config.orientation === 'vertical' &&\n    config.perspective !== 'comparative' &&\n    config.geometry !== 'collinear'\n  ) {\n    ideoWidth =\n      (ideo.numChromosomes) *\n      (config.chrWidth + config.chrMargin + annotHeight);\n  } else {\n    return;\n  }\n\n  if (config.annotationsLayout === 'heatmap-2d') {\n    return;\n  }\n\n  ideoWidth = Math.ceil(ideoWidth * ploidyPad / config.rows);\n  if (ideo._layout._class === 'SmallLayout') ideoWidth += 100;\n\n  ideoWidth += 35; // Account for settings gear\n\n  // Ensures absolutely-positioned elements, e.g. heatmap overlaps, display\n  // properly if ideogram container also has position: absolute\n  ideoMiddleWrap.style('height', ideo._layout.getHeight() + 'px');\n\n  ideoInnerWrap\n    .style('max-width', ideoWidth + 'px')\n    .style('overflow-x', 'scroll')\n    .style('position', 'absolute');\n\n  ideoSvg.style('min-width', (ideoWidth - 5) + 'px');\n\n  if (ideo.config.showTools) {\n    initTools(ideo);\n  }\n}\n\nexport {\n  appendHomolog, drawChromosome, rotateAndToggleDisplay, setOverflowScroll\n};\n","import {d3} from '../lib';\n\nfunction getChrSetLabelLines(d, i, ideo) {\n  var lines;\n  if (d.name.indexOf(' ') === -1) {\n    lines = [d.name];\n  } else {\n    lines = d.name.match(/^(.*)\\s+([^\\s]+)$/).slice(1).reverse();\n  }\n\n  if (\n    'sex' in ideo.config &&\n    ideo.config.ploidy === 2 &&\n    i === ideo.sexChromosomes.index\n  ) {\n    if (ideo.config.sex === 'male') {\n      lines = ['XY'];\n    } else {\n      lines = ['XX'];\n    }\n  }\n\n  return lines;\n}\n\nfunction renderChromosomeSetLabel(d, i, textElement, ideo) {\n  // Get label lines\n  var lines = getChrSetLabelLines(d, i, ideo);\n\n  // Render label lines\n  d3.select(textElement).selectAll('tspan')\n    .data(lines)\n    .enter()\n    .append('tspan')\n    .attr('dy', function(d, i) {\n      return i * -1.2 + 'em';\n    })\n    .attr('x', ideo._layout.getChromosomeSetLabelXPosition())\n    .attr('class', function(a, i) {\n      var fullLabels = ideo.config.fullChromosomeLabels;\n      return i === 1 && fullLabels ? 'italic' : null;\n    })\n    .text(String);\n}\n\nfunction appendChromosomeSetLabels(ideo) {\n  var layout = ideo._layout;\n\n  d3.selectAll(ideo.selector + ' .chromosome-set')\n    .insert('text', ':first-child')\n    .data(ideo.chromosomesArray)\n    .attr('class', layout.getChromosomeLabelClass())\n    .attr('transform', layout.getChromosomeSetLabelTranslate())\n    .attr('x', layout.getChromosomeSetLabelXPosition())\n    .attr('y', function(d, i) {\n      return layout.getChromosomeSetLabelYPosition(i);\n    })\n    .attr('text-anchor', layout.getChromosomeSetLabelAnchor())\n    .each(function(d, i) {\n      renderChromosomeSetLabel(d, i, this, ideo);\n    });\n}\n\nfunction appendChromosomeLabels(ideo) {\n  var layout = ideo._layout;\n\n  d3.selectAll(ideo.selector + ' .chromosome-set')\n    .each(function(a, chrSetIndex) {\n      d3.select(this).selectAll('.chromosome')\n        .append('text')\n        .attr('class', 'chrLabel')\n        .attr('transform', layout.getChromosomeSetLabelTranslate())\n        .attr('x', function(d, i) {\n          return layout.getChromosomeLabelXPosition(i);\n        })\n        .attr('y', function(d, i) {\n          return layout.getChromosomeLabelYPosition(i);\n        })\n        .text(function(d, chrIndex) {\n          return ideo._ploidy.getAncestor(chrSetIndex, chrIndex);\n        })\n        .attr('text-anchor', 'middle');\n    });\n}\n\n/**\n * Draws labels for each chromosome, e.g. \"1\", \"2\", \"X\".\n * If ideogram configuration has 'fullChromosomeLabels: True',\n * then labels includes name of taxon, which can help when\n * depicting orthologs.\n */\nfunction drawChromosomeLabels() {\n  var ideo = this;\n  appendChromosomeSetLabels(ideo);\n  appendChromosomeLabels(ideo);\n}\n\nfunction getLabelPositionAttrs(scale) {\n  var x, y, scaleSvg;\n\n  if (\n    typeof (scale) !== 'undefined' &&\n    scale.hasOwnProperty('x') &&\n    !(scale.x === 1 && scale.y === 1)\n  ) {\n    scaleSvg = 'scale(' + scale.x + ',' + scale.y + ')';\n    x = -6;\n    y = (scale === '' ? -16 : -14);\n  } else {\n    x = -8;\n    y = -16;\n    scale = {x: 1, y: 1};\n    scaleSvg = '';\n  }\n\n  return {x: x, y: y, scaleSvg: scaleSvg, scale: scale};\n}\n\nfunction updateChrIndex(chrIndex, config) {\n  if (config.numAnnotTracks > 1 || config.orientation === '') chrIndex -= 1;\n  return chrIndex;\n}\n\nfunction rotateVerticalChromosomeLabels(chr, chrIndex, labelPosAttrs, ideo) {\n  var chrMargin2, chrMargin, y,\n    config = ideo.config;\n\n  chrIndex = updateChrIndex(chrIndex, config);\n\n  chrMargin2 = -4;\n  if (config.showBandLabels === true) {\n    chrMargin2 = config.chrMargin + config.chrWidth + 26;\n  }\n\n  chrMargin = config.chrMargin * chrIndex;\n  if (config.numAnnotTracks > 1 === false) chrMargin += 1;\n\n  y = chrMargin + chrMargin2;\n\n  chr.selectAll('text.chrLabel')\n    .attr('transform', labelPosAttrs.scaleSvg)\n    .selectAll('tspan')\n    .attr('x', labelPosAttrs.x)\n    .attr('y', y);\n}\n\nfunction rotateHorizontalChromosomeLabels(chr, chrIndex, labelPosAttrs, ideo) {\n  var chrMargin, chrMargin2, tracksHeight, x,\n    config = ideo.config;\n\n  chrMargin2 = -config.chrWidth - 2;\n  if (config.showBandLabels === true) chrMargin2 = config.chrMargin + 8;\n\n  tracksHeight = config.annotTracksHeight;\n  if (config.annotationsLayout !== 'overlay') tracksHeight *= 2;\n\n  chrMargin = config.chrMargin * chrIndex;\n  x = -(chrMargin + chrMargin2) + 3 + tracksHeight;\n  x /= labelPosAttrs.scale.x;\n\n  chr.selectAll('text.chrLabel')\n    .attr('transform', 'rotate(-90)' + labelPosAttrs.scaleSvg)\n    .selectAll('tspan')\n    .attr('x', x)\n    .attr('y', labelPosAttrs.y);\n}\n\n/**\n * Rotates chromosome labels by 90 degrees, e.g. upon clicking a chromosome.\n */\nfunction rotateChromosomeLabels(chr, chrIndex, orientation, scale) {\n  var labelPosAttrs,\n    ideo = this;\n\n  chrIndex -= 1;\n\n  labelPosAttrs = getLabelPositionAttrs(scale);\n\n  if (orientation === 'vertical' || orientation === '') {\n    rotateVerticalChromosomeLabels(chr, chrIndex, labelPosAttrs, ideo);\n  } else {\n    rotateHorizontalChromosomeLabels(chr, chrIndex, labelPosAttrs, ideo);\n  }\n}\n\nexport {drawChromosomeLabels, rotateChromosomeLabels};\n","/** Get time in milliseconds between a start time (t0) and now */\nfunction timeDiff(t0) {\n  return Math.round(performance.now() - t0);\n}\n\n/** Initialize performance analysis settings */\nfunction initAnalyzeRelatedGenes(ideo) {\n  ideo.time = {\n    rg: { // times for related genes\n      t0: performance.now()\n    }\n  };\n  if ('_didRelatedGenesFirstPlot' in ideo) {\n    delete ideo._didRelatedGenesFirstPlot;\n  }\n}\n\nfunction getRelatedGenesByType() {\n  const ideo = this;\n  const relatedGenes = ideo.annotDescriptions.annots;\n\n  const related = Object.values(relatedGenes).slice();\n\n  const paralogous = related.filter(r => {\n    return r.type && r.type.includes('paralogous');\n  });\n  const interacting = related.filter(r => {\n    return r.type && r.type.includes('interacting gene');\n  });\n  const searched = Object.entries(relatedGenes).filter(entry => {\n    return entry[1].type && entry[1].type.includes('searched gene');\n  })[0][0];\n\n  return {related, paralogous, interacting, searched};\n}\n\nfunction getRelatedGenesTooltipAnalytics(annot) {\n  const ideo = this;\n\n  const timeSincePrevTooltip = performance.now() - ideo.time.prevTooltipOff;\n  const prevAnnotDomId = ideo.time.prevTooltipAnnotDomId;\n\n  if (timeSincePrevTooltip < 300 && annot.domId === prevAnnotDomId) {\n    return null;\n  }\n\n  const tooltipGene = annot.name;\n\n  // e.g. \"interacting gene\" -> \"interacting\"\n  const tooltipRelatedType =\n    ideo.annotDescriptions.annots[annot.name].type.split(' ')[0];\n\n  const countsByType = getCountsByType(ideo);\n\n  const analytics = Object.assign(\n    {tooltipGene, tooltipRelatedType}, countsByType\n  );\n\n  return analytics;\n}\n\n/** Compute granular related genes plotting analytics */\nfunction analyzePlotTimes(type, ideo) {\n  // Paralogs and interacting genes:\n  // http://localhost:8080/examples/vanilla/related-genes?q=RAD51\n  //\n  // No paralogs:\n  // http://localhost:8080/examples/vanilla/related-genes?q=BRCA1&org=mus-musculus\n  //\n  // No interacting genes:\n  // http://localhost:8080/examples/vanilla/related-genes?q=DMC1\n  //\n  // No paralogs, no interacting genes:\n  // http://localhost:8080/examples/vanilla/related-genes?q=BRCA1&org=macaca-mulatta\n\n  if (type === 'pathway') {\n    return;\n  }\n  const otherTypes = {\n    paralogous: 'interacting',\n    interacting: 'paralogous'\n  };\n  const related = ideo.getRelatedGenesByType();\n  const otherType = otherTypes[type];\n  const numThisRelated = related[type].length;\n  const numOtherRelated = related[otherType] ? related[otherType].length : 0;\n\n  if (!ideo._didRelatedGenesFirstPlot) {\n    // 1st of 2 attempted plot logs\n    ideo._didRelatedGenesFirstPlot = true;\n\n    ideo.time.rg.totalFirstPlot = timeDiff(ideo.time.rg.t0);\n\n    if (numThisRelated > 0) {\n      ideo.time.rg.timestampFirstPlot = performance.now();\n      ideo._relatedGenesFirstPlotType = type;\n    }\n  } else {\n    // 2nd of 2 attempted plot logs\n    if (numThisRelated > 0 && numOtherRelated > 0) {\n      // Paralogs and interacting genes were found, e.g. human RAD51\n      const timestampFirstPlot = ideo.time.rg.timestampFirstPlot;\n      ideo.time.rg.totalLastPlotDiff = timeDiff(timestampFirstPlot);\n    } else if (numThisRelated > 0 && numOtherRelated === 0) {\n      // Other attempt did not plot, and this did, so log this as 1st\n      // Often seen when no interacting genes found, e.g. human DMC1\n      ideo.time.rg.timestampFirstPlot = performance.now();\n      ideo.time.rg.totalFirstPlot = timeDiff(ideo.time.rg.t0);\n      ideo._relatedGenesFirstPlotType = type;\n      ideo.time.rg.totalLastPlotDiff = 0;\n\n    } else if (numThisRelated === 0 && numOtherRelated > 0) {\n      // This attempt did not plot, the other did, so log 1st plot as also last\n      // Often seen when no paralogs found, e.g. mouse BRCA1\n      ideo.time.rg.totalLastPlotDiff = 0;\n    } else {\n      // No related genes found, so note only the searched gene is plotted\n      // Example: Macaca mulatta BRCA1\n      ideo._relatedGenesFirstPlotType = 'searched';\n      ideo.time.rg.totalLastPlotDiff = 0;\n    }\n  }\n}\n\nfunction getCountsByType(ideo) {\n  const related = ideo.getRelatedGenesByType();\n\n  const numRelatedGenes = related['related'].length;\n  const numParalogs = related['paralogous'].length;\n  const numInteractingGenes = related['interacting'].length;\n  const searchedGene = related['searched'];\n\n  return {\n    numRelatedGenes, numParalogs, numInteractingGenes, searchedGene\n  };\n}\n\n/** Summarizes number and kind of related genes, performance, etc. */\nfunction analyzeRelatedGenes(ideo) {\n\n  const countsByType = getCountsByType(ideo);\n\n  const timeTotal = ideo.time.rg.total;\n  const timeTotalFirstPlot = ideo.time.rg.totalFirstPlot;\n  const timeTotalLastPlotDiff = ideo.time.rg.totalLastPlotDiff;\n  const timeParalogs = ideo.time.rg.paralogs;\n  const timeInteractingGenes = ideo.time.rg.interactions;\n  const timeSearchedGene = ideo.time.rg.searchedGene;\n  const firstPlotType = ideo._relatedGenesFirstPlotType;\n\n  const analytics = Object.assign({\n    firstPlotType,\n    timeTotal, timeTotalFirstPlot, timeTotalLastPlotDiff,\n    timeSearchedGene, timeInteractingGenes, timeParalogs\n  }, countsByType);\n\n  ideo.relatedGenesAnalytics = analytics;\n}\n\nexport {\n  initAnalyzeRelatedGenes, analyzePlotTimes, analyzeRelatedGenes, timeDiff,\n  getRelatedGenesByType, getRelatedGenesTooltipAnalytics\n};\n","import {d3} from '../lib';\nimport {getIcon} from '../annotations/legend';\n\nconst y = 15;\n\n// Subtle visual delimiter; separates horizontally adjacent fields in UI\nconst pipe = `<span style='color: #CCC'>|</span>`;\n\nconst utr5 = \"5'-UTR\";\nconst utr3 = \"3'-UTR\";\n\nconst heights = {\n  \"5'-UTR\": 20,\n  'exon': 20,\n  'intron': 20,\n  \"3'-UTR\": 20\n};\n\nconst colors = {\n  \"5'-UTR\": '#155069',\n  'exon': '#DAA521',\n  \"intron\": '#FFFFFF00',\n  \"3'-UTR\": '#357089'\n};\n\nconst lineColors = {\n  \"5'-UTR\": '#70A099',\n  'exon': '#BA8501',\n  \"3'-UTR\": '#90C0B9'\n};\n\nconst subpartClasses = {\n  \"5'-UTR\": 'five-prime-utr',\n  'exon': 'exon',\n  \"3'-UTR\": 'three-prime-utr',\n  'intron': 'intron'\n};\n\nconst css =\n  `<style>\n  ._ideoGeneStructureContainerName {\n    margin-left: 81px;\n  }\n  ._ideoGeneStructureContainerName.pre-mRNA {\n    margin-left: 69px;\n  }\n  ._ideoGeneStructureContainer rect:hover + line {\n    visibility: hidden;\n  }\n  ._ideoGeneStructureContainer {\n    display: flex;\n    justify-content: center;\n    align-items: center;\n    flex-direction: column;\n  }\n  ._ideoGeneStructureContainer:hover ._ideoSpliceToggle {\n    visibility: visible;\n  }\n  ._ideoGeneStructureContainer ._ideoSpliceToggle {\n    visibility: hidden;\n  }\n  ._ideoSpliceToggle {\n    margin-left: 53px; background-color: #EEE;\n  }\n  ._ideoSpliceToggle.pre-mRNA {\n    margin-left: 43px; background-color: #F8F8F8;\n  }\n  ._ideoHoveredSubpart {\n    stroke: #D0D0DD !important; stroke-width: 3px;\n  }\n  </style>`;\n\n/** Get DOM element for gene structure footer */\nfunction getFooter() {\n  return document.querySelector('._ideoGeneStructureFooter');\n}\n\n/** Write transcript details below the diagram */\nfunction writeFooter(container) {\n  const footer = getFooter();\n  const svgDOM = container.querySelector('svg');\n  const transcriptSummary = svgDOM.getAttribute('data-ideo-footer');\n  footer.innerHTML = `&nbsp;<br/>${transcriptSummary}`;\n}\n\n/** Write newly-selected gene structure diagram, header, and footer */\nfunction updateGeneStructure(ideo, offset=0) {\n  const [structure, selectedIndex] = getSelectedStructure(ideo, offset);\n  const isCanonical = (selectedIndex === 0);\n  const menu = document.querySelector('#_ideoGeneStructureMenu');\n  menu.options[selectedIndex].selected = true;\n  const svg = getSvg(structure, ideo, ideo.spliceExons)[0];\n  const container = document.querySelector('._ideoGeneStructureSvgContainer');\n  container.innerHTML = svg;\n  updateHeader(ideo.spliceExons, isCanonical);\n  writeFooter(container);\n  ideo.addedSubpartListeners = false;\n  addHoverListeners(ideo);\n}\n\n/** Get gene symbol from transcript / gene structure name */\nfunction getGeneFromStructureName(structureName) {\n  const gene = structureName.split('-').slice(0, -1).join('-');\n  return gene;\n}\n\n/** Get name of transcript currently selected in menu */\nfunction getSelectedStructure(ideo, offset=0) {\n  let selectedIndex, structureName;\n\n  const menu = document.querySelector('#_ideoGeneStructureMenu');\n  if (!menu) {\n    const svg = document.querySelector('._ideoGeneStructure');\n    if (!svg) return null; // No gene structure is available, e.g. for miRNA\n    structureName = svg.getAttribute('data-ideo-gene-structure-name');\n    selectedIndex = 0;\n  } else {\n    const numOptions = menu.options.length;\n    const baseIndex = menu.selectedIndex;\n    selectedIndex = baseIndex + offset;\n    if (selectedIndex >= numOptions) {\n      selectedIndex = 0;\n    } else if (selectedIndex < 0) {\n      selectedIndex = numOptions - 1;\n    }\n    structureName = menu.options[selectedIndex].value;\n  }\n  const gene = getGeneFromStructureName(structureName);\n  const geneStructure =\n    ideo.geneStructureCache[gene].find(gs => gs.name === structureName);\n\n\n  return [geneStructure, selectedIndex];\n}\n\n/**\n * Add event listeners to the transcript menu:\n * - On click, block upstream listeners from closing tooltip\n * - On change, write newly selected gene structure\n */\nfunction addMenuListeners(ideo) {\n  const menuId = '_ideoGeneStructureMenu';\n  const container = document.querySelector('._ideoGeneStructureContainer');\n\n  // Don't search this gene if clicking to expand the menu\n  container.addEventListener('click', (event) => {\n    if (event.target.id === menuId) {\n      event.stopPropagation();\n    }\n\n    let svgMaybe = event.target;\n    if (svgMaybe.parentElement.tagName === 'svg') {\n      svgMaybe = svgMaybe.parentElement;\n    };\n\n    // Go to next transcript on clicking down arrow icon, previous on up\n    if (Array.from(svgMaybe.classList).includes('_ideoMenuArrow')) {\n      const menuArrow = event.target;\n      const direction = menuArrow.getAttribute('data-dir');\n      const offset = direction === 'down' ? 1 : -1;\n      updateGeneStructure(ideo, offset);\n      event.stopPropagation();\n    }\n  });\n\n  // Go to next transcript on pressing down arrow key, previous on up\n  document.addEventListener('keydown', (event) => {\n    const key = event.key;\n    if (['ArrowDown', 'ArrowUp'].includes(key)) {\n      const offset = key === 'ArrowDown' ? 1 : -1;\n      updateGeneStructure(ideo, offset);\n    }\n  });\n}\n\nfunction toggleSpliceByKeyboard(event) {\n  if (event.key === 's') {\n    const spliceToggle = document.querySelector('._ideoSpliceToggle input');\n    if (!spliceToggle) return;\n\n    const subpartText = document.querySelector('#_ideoSubpartText');\n    if (subpartText) subpartText.innerHTML = '&nbsp;';\n    spliceToggle.dispatchEvent(new MouseEvent('click'));\n  }\n}\n\n/** Listen for keydown and click on / change to splice toggle input */\nfunction addSpliceToggleListeners(ideo) {\n  document.addEventListener('keydown', toggleSpliceByKeyboard);\n\n  const container = document.querySelector('._ideoGeneStructureContainer');\n  const toggler = document.querySelector('._ideoSpliceToggle');\n\n  if (!container) return;\n\n  toggler.addEventListener('change', (event) => {\n    toggleSplice(ideo);\n    addHoverListeners(ideo);\n    event.stopPropagation();\n  });\n}\n\n/** Helper for keyboard navigation */\nfunction nextIsOutOfSubpartBounds(i, subparts, key) {\n  const isLeft = key === 'left';\n  return (\n    i === 0 && isLeft ||\n    i === subparts.length - 1 && !isLeft\n  );\n}\n\n/**\n * Swap genome-ordered subparts so they render with expected visual layering\n *\n * SVG elements render last-on-top, which often hides subparts UTRs at the\n * ends of transcripts when they're genomically ordered, as they are in e.g.\n * Ensembl.\n *\n * See also: swapUTRsBack\n */\nfunction swapUTRsForward(subparts, isPositiveStrand) {\n  const swappedSubparts = subparts.slice();\n\n  // Account for edge case in certain nonsense-mediated-decay transcripts\n  const utr = isPositiveStrand ? utr3 : utr5;\n  const hasUtr = subparts.some(subpart => subpart[0] === utr);\n\n  subparts.forEach((subpart, i) => {\n    if (i === 0) return;\n    const prevSubpart = subparts[i - 1];\n\n    const prevIsUtr3 = prevSubpart[0] === utr3;\n    const prevIsUtr5 = prevSubpart[0] === utr5;\n    const isExon = subpart[0] === 'exon';\n\n    if (\n      isExon && hasUtr && (\n        !isPositiveStrand && prevIsUtr3 ||\n        isPositiveStrand && prevIsUtr5\n      )\n    ) {\n      swappedSubparts[i] = prevSubpart;\n      swappedSubparts[i - 1] = subpart;\n    }\n  });\n\n  return swappedSubparts;\n}\n\nwindow.swapUTRsForward = swapUTRsForward;\n\nfunction is(element, cls) {\n  return element.classList.contains(cls);\n}\n\n// isExon && (\n//   !isPositiveStrand && prevIsUtr3 ||\n//   isPositiveStrand && prevIsUtr5\n// )\n\nfunction shouldSwapBackDOM(subpart, nextSubpart, isPositiveStrand, hasUtr) {\n  const utr5 = 'five-prime-utr';\n  const utr3 = 'three-prime-utr';\n  const nextIsUtr5 = is(nextSubpart, utr5);\n  const nextIsUtr3 = is(nextSubpart, utr3);\n  const isNotUtr3 = !is(subpart, utr3);\n  const isNotUtr5 = !is(subpart, utr5);\n  return (\n    hasUtr && (\n      !isPositiveStrand && nextIsUtr3 && isNotUtr3 ||\n      isPositiveStrand && nextIsUtr5 && isNotUtr5\n    )\n  );\n}\n\nfunction shouldSwapBackData(subpart, nextSubpart, isPositiveStrand, hasUtr) {\n  const nextIsUtr5 = nextSubpart[0] === utr5;\n  const nextIsUtr3 = nextSubpart[0] === utr3;\n  const isNotUtr3 = subpart[0] !== utr3;\n  const isNotUtr5 = subpart[0] !== utr5;\n  return (\n    hasUtr && (\n      !isPositiveStrand && nextIsUtr3 && isNotUtr3 ||\n      isPositiveStrand && nextIsUtr5 && isNotUtr5\n    )\n  );\n}\n\n/**\n * Restore SVG subparts to genome order, for proper keyboard navigation\n *\n * See also: swapUTRsForward\n */\nfunction swapUTRsBack(subparts, isPositiveStrand) {\n  const swappedSubparts = subparts.slice();\n  const isRaw = Array.isArray(subparts[0]);\n\n  // Account for edge case in animating exon splice for\n  // nonsense-mediated-decay transcripts that lack an annotated UTR,\n  // e.g. SREBF-204\n  let hasUtr;\n  if (isRaw) {\n    const utr = isPositiveStrand ? utr3 : utr5;\n    hasUtr = subparts.some(subpart => subpart[0] === utr);\n  } else {\n    const utr5 = 'five-prime-utr';\n    const utr3 = 'three-prime-utr';\n    const utr = isPositiveStrand ? utr3 : utr5;\n    hasUtr = subparts.some(subpart => is(subpart, utr));\n  }\n\n  subparts.forEach((subpart, i) => {\n    if (i === swappedSubparts.length - 1) return;\n    const nextSubpart = subparts[i + 1];\n    const shouldSwapBackFn = isRaw ? shouldSwapBackData : shouldSwapBackDOM;\n    const shouldSwapBack =\n      shouldSwapBackFn(subpart, nextSubpart, isPositiveStrand, hasUtr);\n    if (shouldSwapBack) {\n      swappedSubparts.splice(i, 1, nextSubpart);\n      swappedSubparts.splice(i + 1, 1, subpart);\n    }\n  });\n  return swappedSubparts;\n}\n\n/**\n * Remove any hover stroke outlines, for subpart highlight edge cases like\n * mouseenter in subpart A while distant subpart B is navigated\n */\nfunction removeHighlights() {\n  const cls = '_ideoHoveredSubpart';\n  const hovereds = document.querySelectorAll(`.${cls}`);\n  hovereds.forEach(el => el.classList.remove(cls));\n}\n\n\n/** Go to previous subpart on left arrow; next on right */\nfunction navigateSubparts(event) {\n  const domSubparts = Array.from(document.querySelectorAll('rect.subpart'));\n\n  const structure = document.querySelector('._ideoGeneStructure');\n  const strand = structure.getAttribute('data-ideo-strand');\n  const isPositiveStrand = strand === '+';\n\n  const subparts = swapUTRsBack(domSubparts, isPositiveStrand);\n\n  if (subparts.length === 0) return; // E.g. paralog neighborhoods, lncRNA\n  const cls = '_ideoHoveredSubpart';\n  const subpart = document.querySelector(`.${cls}`);\n  if (!subpart) {\n    // Accounts for edge case when changing transcripts via menu\n    event.stopPropagation();\n    event.preventDefault();\n    return;\n  }\n  let i;\n  subparts.forEach((el, index) => {\n    if (el.classList.contains(cls)) {\n      i = index;\n    }\n  });\n\n  const options = {view: window, bubbles: false, cancelable: true};\n  const mouseEnter = new MouseEvent('mouseenter', options);\n  const mouseLeave = new MouseEvent('mouseleave', options);\n\n  // Account for strand, so left key always goes left; right always right\n  const left = isPositiveStrand ? 'ArrowLeft' : 'ArrowRight';\n  const right = isPositiveStrand ? 'ArrowRight' : 'ArrowLeft';\n  let key;\n  if (event.key === left) {\n    key = 'left';\n  } else if (event.key === right) {\n    key = 'right';\n  }\n\n  // Don't fall off the end\n  if (\n    typeof key === 'undefined' ||\n    nextIsOutOfSubpartBounds(i, subparts, key)\n  ) {\n    event.stopPropagation();\n    event.preventDefault();\n    return;\n  }\n\n  removeHighlights();\n  const alt = event.altKey;\n  const meta = event.metaKey;\n\n  // Jump forward or back by 1, 10, or all subparts\n  if (event.key === left) { // Jump back\n    subpart.dispatchEvent(mouseLeave);\n    let index = i - 1;\n    if (alt) index = i - 10 < 0 ? 0 : i - 10;\n    if (meta) index = 0;\n    const prevSubpart = subparts[index];\n    prevSubpart.dispatchEvent(mouseEnter);\n  } else if (event.key === right) { // Jump forward\n    subpart.dispatchEvent(mouseLeave);\n    const last = subparts.length - 1;\n    let index = i + 1;\n    if (alt) index = i + 10 > last ? last : i + 10;\n    if (meta) index = last;\n    const nextSubpart = subparts[index];\n    nextSubpart.dispatchEvent(mouseEnter);\n  }\n  event.stopPropagation();\n  event.preventDefault();\n}\n\nfunction getMenuContainer() {\n  return document.querySelector('#_ideoGeneStructureMenuContainer');\n}\n\nfunction addSubpartHoverListener(subpartDOM, ideo) {\n  const subpart = subpartDOM;\n\n  // On hovering over subpart, highlight it and show details\n  subpart.addEventListener('mouseenter', event => {\n    removeHighlights();\n    // Highlight hovered subpart, adding an aura around it\n    event.target.classList.add('_ideoHoveredSubpart');\n    // Show details\n    const footer = getFooter();\n    ideo.originalTooltipFooter = footer.innerHTML;\n    const subpartText = subpart.getAttribute('data-subpart');\n    const trimmedFoot = footer.innerHTML.replace('&nbsp;', '');\n    const style = 'style=\"margin-bottom: -10px\"';\n    const id = 'id=\"_ideoSubpartText\"';\n    footer.innerHTML =\n      `<div ${id} ${style}\">${subpartText}</div>${trimmedFoot}`;\n    const menuContainer = getMenuContainer();\n    if (menuContainer) menuContainer.style.marginTop = '';\n  });\n\n  // On hovering out, de-highlight and hide details\n  subpart.addEventListener('mouseleave', event => {\n    event.target.classList.remove('_ideoHoveredSubpart');\n    const footer = getFooter();\n    footer.innerHTML = ideo.originalTooltipFooter;\n    const menuContainer = getMenuContainer();\n    if (menuContainer) menuContainer.style.marginTop = '4px';\n  });\n}\n\n/** Did the mouse event occur inside the tooltip area? */\nfunction isMouseEventInTooltip(event) {\n  const tooltip = document.querySelector('._ideogramTooltip');\n  const box = tooltip.getBoundingClientRect();\n  const x = event.screenX;\n  const y = event.screenY;\n  const inTooltip =\n    (x > box.left && x < box.right && y > box.top && y < box.bottom);\n  return inTooltip;\n}\n\n/**\n * Add handlers for hover events in transcript container and beneath, e.g.:\n *\n * - Show transcript details on hovering near transcript\n * - Show subpart (i.e. exon, 3'-UTR, 5'-UTR) details on hovering over subpart\n * - Highlight subpart on hovering over subpart\n * - Navigate to previous or next subpart on pressing left or right arrow keys\n */\nfunction addHoverListeners(ideo) {\n\n  const subparts = document.querySelectorAll('rect.subpart');\n  if (subparts.length === 0) return; // E.g. paralog neighborhoods, lncRNA\n\n  ideo.subparts = subparts;\n\n  const container = document.querySelector('._ideoGeneStructureContainer');\n\n  container.addEventListener('mouseenter', () => {\n    document.addEventListener('keydown', navigateSubparts);\n    if (ideo.addedMenuListeners) return;\n    ideo.addedMenuListeners = true;\n    writeFooter(container);\n\n    // Listen for change of selected option in transcript menu\n    const tooltip = document.querySelector('._ideogramTooltip');\n    tooltip.addEventListener('change', () => {\n      updateGeneStructure(ideo);\n\n      // Without this, selecting a new transcript will close the tooltip if\n      // the selected <option> screen position is outside the tooltip (as\n      // is often the case in genes with many transcripts, like TP53).\n      ideo.oneTimeDelayTooltipHideMs = 2000; // wait 2.0 s instead of 0.25 s\n    });\n\n  });\n  container.addEventListener('mouseleave', (event) => {\n    ideo.oneTimeDelayTooltipHideMs = 2000; // See \"Without this...\" note above\n    const inTooltip = isMouseEventInTooltip(event);\n    if (inTooltip === true) {\n      // Only remove transcript footer if `mouseleave` event is from footer to\n      // another part of the tooltip.  If `mouseleave`-ing from footer to\n      // *outside* the tooltip -- e.g. when selecting a new transcript as in\n      // the \"Without this...\" scenario noted above -- then do not remove the\n      // footer.  This lets users always see the details in the footer for the\n      // transcript they just selected, rather than having the details\n      // frustratingly disappear immediately upon transcript selection.\n      const footer = getFooter();\n      footer.innerHTML = '';\n    }\n    ideo.addedMenuListeners = false;\n    document.removeEventListener('keydown', navigateSubparts);\n  });\n\n  if (ideo.addedSubpartListeners) return;\n  ideo.addedSubpartListeners = true;\n\n  subparts.forEach(subpart => {\n    addSubpartHoverListener(subpart, ideo);\n  });\n}\n\nfunction writeStrandInFooter(ideo) {\n  const strand = getSelectedStructure(ideo)[0].strand;\n  if (strand === '+') return; // Don't remark if strand is the default\n  const tooltipFooter = document.querySelector('._ideoTooltipFooter');\n  tooltipFooter.innerText =\n    tooltipFooter.innerText.replace(')', `, ${strand})`);\n}\n\nexport function addGeneStructureListeners(ideo) {\n  const structure = getSelectedStructure(ideo);\n  if (structure === null) return; // Bail for e.g. miRNA\n  addSpliceToggleListeners(ideo);\n  addHoverListeners(ideo);\n  addMenuListeners(ideo);\n  writeStrandInFooter(ideo);\n}\n\nfunction getSpliceToggleHoverTitle(spliceExons) {\n  return spliceExons ? 'Unsplice exons (s)' : 'Splice exons (s)';\n}\n\nfunction getSpliceToggle(ideo) {\n  const spliceExons = ideo.spliceExons;\n  const modifier = spliceExons ? '' : 'pre-';\n  const cls = `class=\"_ideoSpliceToggle ${modifier}mRNA\"`;\n  const checked = spliceExons ? 'checked' : '';\n  const text = getSpliceToggleHoverTitle(spliceExons);\n  const title = `title=\"${text}\"`;\n  const inputAttrs =\n    `type=\"checkbox\" ${checked} ` +\n    `style=\"display: none;\"`;\n  const style =\n    'style=\"position: relative; top: -5px; ' +\n    'user-select: none; ' + // Prevent distracting highlight on quick toggle\n    'float: right; cursor: pointer; font-size: 16px; ' +\n    'padding: 2px 4px; border: 1px solid #CCC; border-radius: 3px;\"';\n  const attrs = `${cls} ${style} ${title}`;\n\n  // Scissors icon\n  const label = `<label ${attrs}><input ${inputAttrs} />&#x2702;</label>`;\n  return label;\n}\n\n/** Splice exons in transcript, removing introns; add positions */\nfunction spliceOut(subparts) {\n  const splicedSubparts = [];\n  let prevEnd = 0;\n  let prevStart = 0;\n  for (let i = 0; i < subparts.length; i++) {\n    const subpart = subparts[i];\n    const [subpartType, start, length] = subpart;\n    const isSpliceOverlap = start === prevStart;\n    let prevRawStart, prevRawLength;\n    if (i > 0) {\n      [, prevRawStart, prevRawLength] = subparts[i - 1];\n    }\n\n    // e.g. 5'-UTRs of OXTR\n    const isOtherOverlap = i > 0 && start === prevRawStart;\n\n    // e.g. 3'-UTR of LDLR, or 3'-UTR of CD44\n    const isOther3UTROverlap = i > 0 && start <= prevRawStart + prevRawLength;\n\n    let splicedStart;\n    if (isSpliceOverlap) {\n      splicedStart = start;\n    } else if (isOtherOverlap) {\n      // e.g. 5'-UTRs of OXTR\n      splicedStart = prevStart;\n    } else if (isOther3UTROverlap) {\n      splicedStart = prevStart + prevRawLength - length;\n    } else {\n      splicedStart = prevEnd;\n    }\n    const splicedEnd = splicedStart + length;\n    const splicedSubpart = [subpartType, splicedStart, length + 1];\n    splicedSubparts.push(splicedSubpart);\n    prevEnd = splicedEnd;\n    prevStart = splicedStart;\n  }\n  const splicedPositionedSubparts = addPositions(splicedSubparts);\n  return splicedPositionedSubparts;\n}\n\n/** Insert introns to transcript; add positions */\nfunction spliceIn(subparts) {\n  const splicedSubparts = [];\n  let prevEnd = 0;\n  for (let i = 0; i < subparts.length; i++) {\n    const subpart = subparts[i];\n    const [start, length] = subpart.slice(1);\n    if (start > prevEnd) {\n      const intronStart = prevEnd;\n      const intronLength = start - prevEnd - 1;\n      splicedSubparts.push(['intron', intronStart, intronLength]);\n    }\n    prevEnd = start + length;\n    splicedSubparts.push(subpart);\n  }\n  const splicedPositionedSubparts = addPositions(splicedSubparts);\n  return splicedPositionedSubparts;\n}\n\nfunction getSpliceStateText(spliceExons, isCanonical=true) {\n  let modifier = '';\n  let titleMod = 'without';\n  if (!spliceExons) {\n    modifier = 'pre-';\n    titleMod = 'with';\n  }\n  const canonOrAlt = isCanonical ? 'Canonical' : 'Alternative';\n  const title = `${canonOrAlt} transcript per Ensembl, ${titleMod} introns`;\n  const name = `${canonOrAlt} ${modifier}mRNA`;\n  return {title, name};\n}\n\n\n/** Draw introns in initial splice toggle from mRNA to pre-mRNA */\nfunction drawIntrons(prelimSubparts, matureSubparts, ideo) {\n  // Hypothetical example data, in shorthand\n  // pres = [u5_1, e1, i1, e2, i2, e3, i3, e4, i4, e5, i5, e6, u3_1]\n  // mats = [u5_1, e1, e2, e3, e4, e5, e6, u3_1]\n\n  let numInserted = 0;\n  const subpartEls = document.querySelectorAll('.subpart');\n  prelimSubparts.forEach((prelimSubpart, i) => {\n    const matureIndex = i - numInserted;\n    const matureSubpart = matureSubparts[matureIndex];\n    if (matureSubpart[0] !== prelimSubpart[0]) {\n      const summary = prelimSubpart[3].summary;\n      const otherAttrs = `y=\"15\" height=\"20\" fill=\"#FFFFFF00\" ${summary}`;\n      const intronRect =\n        `<rect class=\"subpart intron\" ${otherAttrs} />`;\n      subpartEls[matureIndex].insertAdjacentHTML('beforebegin', intronRect);\n      numInserted += 1;\n    }\n  });\n\n  document.querySelectorAll('.intron').forEach(subpartDOM => {\n\n    addSubpartHoverListener(subpartDOM, ideo);\n  });\n}\n\nfunction updateHeader(spliceExons, isCanonical) {\n  // Update title for gene structure diagram\n  const nameDOM =\n  document.querySelector('._ideoGeneStructureContainerName');\n  const toggleDOM = document.querySelector('._ideoSpliceToggle');\n\n  if (nameDOM && toggleDOM) {\n    [nameDOM, toggleDOM].forEach(el => el.classList.remove('pre-mRNA'));\n    if (!spliceExons) {\n      [nameDOM, toggleDOM].forEach(el => el.classList.add('pre-mRNA'));\n    }\n    const {title, name} = getSpliceStateText(spliceExons, isCanonical);\n    nameDOM.textContent = name;\n    nameDOM.title = title;\n  }\n}\n\nfunction toggleSplice(ideo) {\n  ideo.spliceExons = !ideo.spliceExons;\n  const spliceExons = ideo.spliceExons;\n  const [structure, selectedIndex] = getSelectedStructure(ideo);\n  const isCanonical = (selectedIndex === 0);\n  const [, prelimSubparts, matureSubparts] =\n    getSvg(structure, ideo, spliceExons);\n\n  const addedIntrons = document.querySelectorAll('.intron').length > 0;\n  if (!spliceExons && !addedIntrons) {\n    drawIntrons(prelimSubparts, matureSubparts, ideo);\n  } else {\n    document.querySelectorAll('.intron').forEach(el => el.remove());\n  }\n  document.querySelectorAll('.subpart-line').forEach(el => el.remove());\n\n  const subparts = spliceExons ? matureSubparts : prelimSubparts;\n\n  d3.select('._ideoGeneStructure').selectAll('.subpart')\n    .data(subparts)\n    .transition()\n    .duration(750)\n    .attr('x', (d, i) => subparts[i][3].x)\n    .attr('width', (d, i) => subparts[i][3].width)\n    .on('end', (d, i) => {\n      if (i !== subparts.length - 1) return;\n\n      // Restore subpart boundary lines\n      const subpartDOMs = document.querySelectorAll('.subpart')\n      subpartDOMs.forEach((subpartDOM, i) => {\n        const subpart = subparts[i];\n        const line = getSubpartBorderLine(subpart);\n        subpartDOM.insertAdjacentHTML('afterend', line);\n      });\n\n      updateHeader(spliceExons, isCanonical);\n\n      const tlbpDOM = document.querySelector('#_ideoTranscriptLengthBp');\n      if (!tlbpDOM) return;\n      const transcriptLengthBp = getTranscriptLengthBp(subparts, spliceExons);\n      const prettyLength = transcriptLengthBp.toLocaleString();\n      tlbpDOM.innerText = `${prettyLength} bp`;\n    });\n}\n\nfunction getTranscriptLengthBp(subparts, spliceExons=false) {\n  const exons = subparts.filter(sp => sp[0] === 'exon');\n  if (spliceExons) subparts = exons;\n\n  const lastSubpart = subparts.slice(-1)[0];\n  const lastStart = lastSubpart[1];\n  const lastLength = lastSubpart[2];\n  const exonFill = spliceExons ? exons.length - 1 : 0;\n\n  const transcriptLengthBp = lastStart + lastLength + exonFill;\n  return transcriptLengthBp;\n}\n\n/** Merge subpart type, pixel-x position, and pixel width to each subpart */\nfunction addPositions(subparts) {\n  const transcriptLengthBp = getTranscriptLengthBp(subparts);\n\n  const transcriptLengthPx = 250;\n\n  const bpPerPx = transcriptLengthBp / transcriptLengthPx;\n\n  for (let i = 0; i < subparts.length; i++) {\n    const subpart = subparts[i];\n    if (subpart.length !== 3) continue;\n    // Define subpart position, tooltip footer\n    const lengthBp = subpart[2];\n    const x = subpart[1] / bpPerPx;\n    const width = lengthBp / bpPerPx;\n    const type = subpart[0];\n\n    subparts[i].push({type, x, width});\n  }\n\n  return subparts;\n}\n\n/** Get text shown below diagram upon hovering over an exon, intron, or UTR */\nfunction getSubpartSummary(subpartType, total, index, strand, lengthBp) {\n  if (strand === '-') index = total - index + 1;\n  const numOfTotal = total > 1 ? `${index} of ${total} ` : '';\n  const prettyType = subpartType[0].toUpperCase() + subpartType.slice(1);\n  const prettyLength = lengthBp.toLocaleString();\n  const html = `${prettyType} ${numOfTotal}${pipe} ${prettyLength} bp`;\n  const summary = `data-subpart=\"${html}\"`;\n  return summary;\n}\n\n/** Get subtle line to visually demarcate subpart boundary */\nfunction getSubpartBorderLine(subpart) {\n  const subpartType = subpart[0];\n  // Define subpart border\n  const x = subpart[3].x;\n  const height = heights[subpartType];\n  const lineHeight = y + height;\n  const lineStroke = `stroke=\"${lineColors[subpartType]}\"`;\n  const lineAttrs = // \"\";\n    `x1=\"${x}\" x2=\"${x}\" y1=\"${y}\" y2=\"${lineHeight}\" ${lineStroke}`;\n  return `<line class=\"subpart-line\" ${lineAttrs} />`;\n}\n\n// function getSvgList(gene, ideo, spliceExons=false) {\n//   if (\n//     'geneStructureCache' in ideo === false ||\n//     gene in ideo.geneStructureCache === false\n//   ) {\n//     return [null];\n//   }\n\n//   const svgList = ideo.geneStructureCache[gene].map(geneStructure => {\n//     return getSvg(geneStructure, ideo, spliceExons);\n//   });\n\n//   return svgList;\n// }\n\n/** Get SVG, and prelimnary and mature subparts for given gene structure */\nfunction getSvg(geneStructure, ideo, spliceExons=false) {\n  const strand = geneStructure.strand;\n\n  const rawSubparts = geneStructure.subparts;\n  let subparts;\n\n  let prelimSubparts = spliceIn(rawSubparts);\n  let matureSubparts = spliceOut(rawSubparts);\n  if (spliceExons) {\n    subparts = matureSubparts;\n  } else {\n    subparts = prelimSubparts;\n  }\n\n  const spliceToggle = document.querySelector('._ideoSpliceToggle');\n  if (spliceToggle) {\n    const title = getSpliceToggleHoverTitle(spliceExons);\n    spliceToggle.title = title;\n  }\n\n  const featureLengthPx = 250 - 2; // Snip to avoid overextending\n\n  const intronHeight = 1;\n  const intronColor = 'black';\n  const geneStructureArray = [];\n\n  const intronPosAttrs =\n    `x=\"0\" width=\"${featureLengthPx}\" y=\"${y + 10}\" height=\"${intronHeight}\"`;\n  const intronRect =\n    `<rect fill=\"black\" ${intronPosAttrs}/>`;\n\n  geneStructureArray.push(intronRect);\n\n  // Set up counters for e.g. \"Exon 2 of 4\" (\"<subpart> <num> of <total>\")\n  const indexBySubpart = {\n    \"5'-UTR\": 0,\n    'exon': 0,\n    'intron': 0,\n    \"3'-UTR\": 0\n  };\n  const totalBySubpart = {\n    \"5'-UTR\": 0,\n    'exon': 0,\n    'intron': 0,\n    \"3'-UTR\": 0\n  };\n\n  const isPositiveStrand = strand === '+';\n  subparts = swapUTRsForward(subparts, isPositiveStrand);\n\n  prelimSubparts = swapUTRsForward(prelimSubparts, isPositiveStrand);\n  matureSubparts = swapUTRsForward(matureSubparts, isPositiveStrand);\n\n  // Container for positional data: x, width\n  // const prelimPositions = getPositions(prelimSubparts);\n  // const maturePositions = getPositions(matureSubparts);\n\n  // matureSubparts = matureSubparts.filter(p => p[0] !== 'intron');\n  // const positions = spliceExons ? trimmedMatures : prelimPositions;\n\n  // Get counts for e.g. \"4\" in \"Exon 2 of 4\"\n  for (let i = 0; i < subparts.length; i++) {\n    const subpart = subparts[i];\n    const subpartType = subpart[0];\n    if (subpartType in totalBySubpart) {\n      totalBySubpart[subpartType] += 1;\n    }\n  }\n\n  for (let i = 0; i < subparts.length; i++) {\n    const subpart = subparts[i];\n    // const position = positions[i];\n    const subpartType = subpart[0];\n    let color = intronColor;\n    if (subpartType in colors) {\n      color = colors[subpartType];\n    }\n\n    const height = heights[subpartType];\n\n    // Define subpart position, tooltip footer\n    const lengthBp = subpart[2];\n    const x = subpart[3].x;\n    const width = subpart[3].width;\n\n    const pos = `x=\"${x}\" width=\"${width}\" y=\"${y}\" height=\"${height}\"`;\n    const cls = `class=\"subpart ${subpartClasses[subpartType]}\" `;\n\n    // TODO: Handle introns better, refine CDS vs. UTR in exons\n    const total = totalBySubpart[subpartType];\n    indexBySubpart[subpartType] += 1;\n    const subpartIndex = indexBySubpart[subpartType];\n    const summary =\n      getSubpartSummary(subpartType, total, subpartIndex, strand, lengthBp);\n    if (!spliceExons) {\n      prelimSubparts[i][3].summary = summary;\n    } else if (subpartType !== 'intron') {\n      matureSubparts[i][3].summary = summary;\n    }\n\n    const subpartSvg = (\n      `<rect ${cls} rx=\"1.5\" fill=\"${color}\" ${pos} ${summary}/>` +\n      getSubpartBorderLine(subpart)\n    );\n    geneStructureArray.push(subpartSvg);\n  }\n\n  const sharedStyle =\n    'position: relative; width: 274px; margin: auto;';\n  let transform = `style=\"${sharedStyle} left: 10px;\"`;\n  if (strand === '-') {\n    transform =\n      'transform=\"scale(-1 1)\" ' +\n      `style=\"${sharedStyle} left: -10px;\"`;\n  }\n\n  const transcriptLengthBp = getTranscriptLengthBp(subparts, spliceExons);\n  const prettyLength = transcriptLengthBp.toLocaleString();\n  const footerDetails = [\n    `${totalBySubpart['exon']} exons`,\n    `<span id='_ideoTranscriptLengthBp'>${prettyLength} bp</span> `\n  ];\n  const biotypeText = geneStructure.biotype.replace(/_/g, ' ');\n  if (biotypeText !== 'protein coding') {\n    footerDetails.push(biotypeText);\n  }\n\n  const structureName = geneStructure.name;\n  const gene = getGeneFromStructureName(structureName);\n  const menu = getMenu(gene, ideo, structureName).replaceAll('\"', '\\'');\n  const footerData = menu + footerDetails.join(` ${pipe} `);\n  const geneStructureSvg =\n    `<svg class=\"_ideoGeneStructure\" ` +\n      `data-ideo-gene-structure-name=\"${structureName}\" ` +\n      `data-ideo-strand=\"${strand}\" data-ideo-footer=\"${footerData}\" ` +\n      `width=\"${(featureLengthPx + 20)}\" height=\"40\" ${transform}` +\n    `>` +\n      geneStructureArray.join('') +\n    '</svg>';\n\n  return [geneStructureSvg, prelimSubparts, matureSubparts];\n}\n\n/** Get down and up arrows for one-click, carousel-like navigation for menu */\nfunction getMenuArrows() {\n\n  // Get attributes\n  const style =\n    'width: 12px; height: 12px; cursor: pointer;' +\n    'user-select: none;'; // Prevent distracting highlight on quick clicks\n  const downStyle = `style=\"${style}; margin-left: 5px;\"`;\n  const upStyle = `style=\"${style}; margin-left: 2px;\"`;\n  const cls = 'class=\"_ideoMenuArrow\"';\n  const downTitle = `<title>Next transcript (down arrow)</title>`;\n  const upTitle = `<title>Previous transcript (up arrow)</title>`;\n  const downAttrs = `${downStyle} ${cls} data-dir=\"down\"`;\n  const upAttrs = `${upStyle} ${cls} data-dir=\"up\"`;\n\n  // Get SVG polygon elements\n  const down = getIcon(\n    {shape: 'triangle', color: '#888'},\n    {config: {orientation: 'down'}}\n  );\n  const up = getIcon({shape: 'triangle', color: '#888'}, {config: ''});\n\n  const downArrow = `<svg ${downAttrs}>${downTitle}${down}</svg>`;\n  const upArrow = `<svg ${upAttrs}>${upTitle}${up}</svg>`;\n  const menuArrows = downArrow + upArrow;\n\n  return menuArrows;\n}\n\n/** Get menu for all transcripts for this gene */\nfunction getMenu(gene, ideo, selectedName) {\n  const containerId = '_ideoGeneStructureMenuContainer';\n  const style = 'margin-bottom: 4px; margin-top: 4px; clear: both;';\n\n  const structures = ideo.geneStructureCache[gene];\n\n  if (structures.length === 1) {\n    const name = structures[0].name;\n    const line =\n      `<div id=\"${containerId}\" style=\"${style}\">Transcript: ${name}</div>`;\n    return line;\n  }\n\n  const options = structures.map(structure => {\n    const name = structure.name;\n    let selected = '';\n    if (selectedName && selectedName === structure.name) {\n      selected = ' selected';\n    }\n    return `<option value=\"${name}\" ${selected}>${name}</option>`;\n  }).join('');\n\n  const id = '_ideoGeneStructureMenu';\n\n  const menuArrows = getMenuArrows();\n\n  const menu =\n    `<div id=\"${containerId}\" style=\"${style}\">` +\n      `<label for=\"${id}\">Transcript:</label> ` +\n      `<select id=\"${id}\" name=\"${id}\">${options}</select>` +\n      menuArrows +\n    `</div>`;\n  return menu;\n}\n\nexport function getGeneStructureHtml(annot, ideo, isParalogNeighborhood) {\n  let geneStructureHtml = '';\n  const gene = annot.name;\n  if (\n    ideo.config.showGeneStructureInTooltip && !isParalogNeighborhood &&\n    !(\n      'geneStructureCache' in ideo === false ||\n      gene in ideo.geneStructureCache === false\n    )\n  ) {\n    ideo.addedSubpartListeners = false;\n    if ('spliceExons' in ideo === false) ideo.spliceExons = true;\n    const spliceExons = ideo.spliceExons;\n    const structure = ideo.geneStructureCache[gene][0];\n    const geneStructureSvg = getSvg(structure, ideo, spliceExons)[0];\n    const cls = 'class=\"_ideoGeneStructureContainer\"';\n    const toggle = getSpliceToggle(ideo);\n    const rnaClass = spliceExons ? '' : ' pre-mRNA';\n    const spanClass = `class=\"_ideoGeneStructureContainerName${rnaClass}\"`;\n    const {name, title} = getSpliceStateText(spliceExons);\n    const spanAttrs = `${spanClass} title=\"${title}\"`;\n    geneStructureHtml =\n      '<br/><br/>' +\n      css +\n      `<div ${cls}>` +\n      `<div><span ${spanAttrs}>${name}</span>${toggle}</div>` +\n      `<span class=\"_ideoGeneStructureSvgContainer\">` +\n        geneStructureSvg +\n      `</span>` +\n      `<div class=\"_ideoGeneStructureFooter\"></div>` +\n      `</div>`;\n\n  }\n  return geneStructureHtml;\n}\n","import {decompressSync, strFromU8} from 'fflate';\nimport { sortAnnotsByRank } from '../annotations/annotations';\n\n// Definitions for ArrowHead values in WikiPathways GPML\n//\n// See also: https://discover.nci.nih.gov/mim/formal_mim_spec.pdf\nconst interactionArrowMap = {\n  'Arrow': ['acts on', 'acted on by'],\n  'TBar': ['inhibits', 'inhibited by'],\n  'mim-binding': ['binds', 'binds'],\n  'mim-catalysis': ['catalyzes', 'catalyzed by'],\n  'mim-cleavage': ['cleaves', 'cleaved by'],\n  'mim-conversion': ['converts', 'converted by'],\n  // 'mim-covalent-bond': ['covalently binds',\n  'mim-gap': ['interacts with', 'interacts with'],\n  'mim-inhibition': ['inhibits', 'inhibited by'],\n  'mim-modification': ['modifies', 'modified by'],\n  'mim-necessary-stimulation':\n    ['necessarily stimulates', 'necessarily stimulated by'],\n  'mim-stimulation': ['stimulates', 'stimulated by'],\n  'mim-transcription-translation':\n    ['transcribes / translates', 'transcribed / translated by']\n};\n\n// Which interactions types to show first, if showing multiple\nconst rankedInteractionTypes = [\n  'transcribe',\n  'cleave',\n  'convert',\n  'bind',\n  'modifie',\n  'catalyze',\n  'necessarily stimulate',\n  'inhibit',\n  'stimulate',\n  'act'\n];\n\nexport function sortInteractionTypes(a, b) {\n  const ranks = {};\n  for (let i = 0; i < rankedInteractionTypes.length; i++) {\n    const rankedIxnType = rankedInteractionTypes[i];\n    if (rankedIxnType.includes(a)) ranks.a = i;\n    if (rankedIxnType.includes(b)) ranks.b = i;\n  }\n  return ranks.b - ranks.a;\n}\n\n/** Determine if all given interactions in *one* pathway are same */\nfunction determineIxnsInPathwayAreSame(ixns, ixnTypeReference) {\n  let isRefMatch = true;\n  let thisIsSame = true;\n\n  if (ixns.length === 0) return {isRefMatch, thisIsSame};\n\n  const thisIxnTypeReference = ixns[0].ixnType.toLowerCase();\n  ixns.forEach(ixn => {\n    const ixnType = ixn.ixnType.toLowerCase();\n    if (ixnType !== ixnTypeReference) {\n      isRefMatch = false;\n    }\n    if (ixnType !== thisIxnTypeReference) {\n      thisIsSame = false;\n    }\n  });\n  return {isRefMatch, thisIsSame};\n}\n\n/**\n * Return first valid interaction type from interactions-by-pathway object\n */\nfunction getIxnTypeReference(ixnsByPwid) {\n  const ixnTypeReference = Object.values(ixnsByPwid).find(ixns => {\n    return ixns.length > 0 && 'ixnType' in ixns[0];\n  })[0].ixnType.toLowerCase();\n\n  return ixnTypeReference;\n}\n\n/**\n * Determine whether all given interactions in all given pathways are the same\n */\nfunction setIsSame(enrichedIxns) {\n  let isSame = true;\n  const ixnsByPwid = enrichedIxns.ixnsByPwid;\n\n  const ixnTypeReference = getIxnTypeReference(ixnsByPwid);\n\n  Object.entries(ixnsByPwid).map(([pwid, ixns]) => {\n    const {isRefMatch, thisIsSame} =\n      determineIxnsInPathwayAreSame(ixns, ixnTypeReference);\n    if (!thisIsSame || !isRefMatch) {\n      isSame = false;\n    }\n    enrichedIxns.isSameByPwid[pwid] = thisIsSame;\n  });\n  enrichedIxns.isSame = isSame;\n\n  return enrichedIxns;\n}\n\n/**\n * If interactions aren't all exactly the same, then they are often still\n * directionally equivalent.\n *\n * E.g. if gene A both \"modifies\" and \"converts\" gene B, then we can summarize\n * that as gene A \"acts on\" gene B, rather than completely reverting to saying\n * gene A \"interacts with\" gene B.\n *\n */\nfunction summarizeByDirection(enrichedIxns) {\n\n  let isDirectionSame = true;\n\n  const leftTypes = []; // \"Acts on\" types\n  const rightTypes = []; // \"Acted on by\" types\n  Object.values(interactionArrowMap).forEach(directedTypes => {\n    rightTypes.push(directedTypes[0]);\n    leftTypes.push(directedTypes[1]);\n  });\n\n  const right = 'Acts on';\n  const left = 'Acted on by';\n\n  const ixnsByPwid = enrichedIxns.ixnsByPwid;\n  const firstIxnType = getIxnTypeReference(ixnsByPwid);\n  const isRight = rightTypes.includes(firstIxnType);\n  const directionReference = isRight ? right : left;\n\n  Object.entries(ixnsByPwid).map(([pwid, ixns]) => {\n    let isPwDirectionSame = true;\n    if (ixns.length > 0) {\n      const pwFirstIxnType = ixns[0].ixnType.toLowerCase();\n      const pwIsRight = rightTypes.includes(pwFirstIxnType);\n      const pwDirectionReference = pwIsRight ? right : left;\n      ixns.forEach(ixn => {\n        const ixnType = ixn.ixnType.toLowerCase();\n        const thisIsRight = rightTypes.includes(ixnType);\n        const direction = thisIsRight ? right : left;\n        enrichedIxns.directionsByPwid[pwid] = direction;\n        if (direction !== directionReference) {\n          isDirectionSame = false;\n        }\n        if (direction !== pwDirectionReference) {\n          isPwDirectionSame = false;\n        }\n      });\n    }\n    enrichedIxns.isDirectionSameByPwid[pwid] = isPwDirectionSame;\n\n  });\n\n  enrichedIxns.isDirectionSame = isDirectionSame;\n  if (isDirectionSame === true) {\n    enrichedIxns.direction = directionReference;\n  }\n\n  return enrichedIxns;\n}\n\n/**\n * Summarize interactions by direction\n *\n * @param {String} gene Interacting gene\n * @param {String} searchedGene Searched gene\n * @param {Array} pathwayIds List of WikiPathways IDs\n * @param {Object} gpmls Object of parsed GPML XMLs values, by pathway ID key\n * @returns\n */\nexport function summarizeInteractions(gene, searchedGene, pathwayIds, gpmls) {\n  let summary = null;\n\n  // Coarse interactions are cached offline, so if not connected to Internet\n  // then fallback to generic summary.\n  if (!navigator.onLine) return 'Interacts with';\n\n  const ixnsByPwid =\n    detailAllInteractions(gene, searchedGene, pathwayIds, gpmls);\n\n  const ixns = ixnsByPwid[pathwayIds[0]];\n\n  if (ixns.length > 0) {\n    let enrichedIxns = {\n      ixnsByPwid,\n      isSameByPwid: {}, // If pathway has all same interaction types\n      isSame: null, // If above is true for all pathways\n      isDirectionSameByPwid: {}, // If pathway has same ixn direction\n      isDirectionSame: null, // If above is true for all pathways\n      directionsByPwid: {}\n    };\n    enrichedIxns = setIsSame(enrichedIxns);\n\n    if (enrichedIxns.isSame) {\n      const ixnType = ixns[0].ixnType;\n      const newIxn = ixnType;\n      summary = newIxn;\n    } else {\n\n      enrichedIxns = summarizeByDirection(enrichedIxns);\n\n      if (enrichedIxns.isDirectionSame) {\n        summary = enrichedIxns.direction;\n      } else {\n        summary = 'Interacts with';\n      }\n    }\n  }\n\n\n    // if (direction !== null) {\n    //   summary = direction;\n    // }\n    // const pwidsByIxnType = {};\n    // Object.entries(ixns).map(([k, v]) => {\n    //   if (!pwidsByIxnType[v.ixnType]) {\n    //     pwidsByIxnType[v.ixnType] = [v.pathwayId];\n    //   } else {\n    //     pwidsByIxnType[v.ixnType].push([v.pathwayId]);\n    //   }\n    // });\n\n    // console.log('pwidsByIxnType')\n    // console.log(pwidsByIxnType)\n    // const tpArray = Object.entries(pwidsByIxnType);\n    // const sortedIndices = sortInteractionTypes(tpArray.map(tp => tp[0]));\n    // const sortedTpArray =\n    //   sortedIndices.map(sortedIndex => tpArray[sortedIndex]);\n\n    // console.log('sortedTpArray')\n    // console.log(sortedTpArray)\n  return summary;\n}\n\n/**\n * Get detailInteractions results for multiple pathways\n *\n * @param gene Interacting gene\n * @param pathwayIds List of WikiPathways IDs\n * @ideo ideo Ideogram instance object\n */\nexport function detailAllInteractions(gene, searchedGene, pathwayIds, gpmls) {\n  const ixnsByPwid = {};\n\n  pathwayIds.map(pathwayId => {\n    const gpml = gpmls[pathwayId];\n    const ixns = detailInteractions(gene, searchedGene, gpml);\n\n    ixnsByPwid[pathwayId] = ixns;\n  });\n  return ixnsByPwid;\n}\n\n/** Get IDs and data element objects for searched or interacting gene */\nfunction getMatches(gpml, label) {\n\n  const nodes = Array.from(gpml.querySelectorAll(\n    `DataNode[TextLabel=\"${label}\"]`\n  ));\n\n  const genes = nodes.map(node => {\n    return {\n      type: 'node',\n      matchedLabel: label,\n      textLabel: node.getAttribute('TextLabel'),\n      graphId: node.getAttribute('GraphId'),\n      groupRef: node.getAttribute('GroupRef')\n    };\n  });\n\n  // Get group identifiers\n  const geneGraphIds = genes.map(g => g.graphId);\n  const geneGroupRefs = genes.map(g => g.groupRef);\n  const groupSelectors =\n    geneGroupRefs.map(ggr => `Group[GroupId=\"${ggr}\"]`).join(',');\n\n  let geneGroups = [];\n  if (groupSelectors !== '') {\n    const groups = gpml.querySelectorAll(groupSelectors);\n    geneGroups = Array.from(groups).map(group => {\n      return {\n        type: 'group',\n        matchedLabel: label,\n        graphId: group.getAttribute('GraphId'),\n        groupId: group.getAttribute('GroupId')\n      };\n    });\n  }\n\n  const geneGroupGraphIds = geneGroups.map(g => g.graphId);\n  const matchingGraphIds = geneGraphIds.concat(geneGroupGraphIds);\n\n  const elements = genes.concat(geneGroups);\n\n  return [matchingGraphIds, elements];\n}\n\nasync function fetchGpml(pathwayId) {\n  const pathwayFile = `${pathwayId}.xml.gz`;\n  const gpmlUrl = `https://cdn.jsdelivr.net/npm/ixn2/${pathwayFile}`;\n  const response = await fetch(gpmlUrl);\n  const blob = await response.blob();\n  const uint8Array = new Uint8Array(await blob.arrayBuffer());\n  const rawGpml = strFromU8(decompressSync(uint8Array));\n\n  const gpml = new DOMParser().parseFromString(rawGpml, 'text/xml');\n\n  // console.log('gpml:')\n  // console.log(gpml)\n\n  return gpml;\n}\n\n/**\n * Request compressed GPML files, which contain detailed interaction data, e.g.\n * https://cdn.jsdelivr.net/npm/ixn/WP3982.xml.gz\n *\n * For more easily readable versions, see also:\n * - https://www.wikipathways.org/index.php?title=Pathway:WP3982&action=edit\n * - https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=gpml&pwTitle=Pathway:WP3982\n *\n * GPML (Graphical Pathway Markup Language) data encodes detailed interaction\n * data for biochemical pathways.\n */\nexport function fetchGpmls(ideo) {\n\n  const pathwayIdsByInteractingGene = {};\n  Object.entries(ideo.annotDescriptions.annots)\n    .forEach(([annotName, descObj]) => {\n      if ('type' in descObj && descObj.type.includes('interacting gene')) {\n        pathwayIdsByInteractingGene[annotName] = descObj.pathwayIds;\n      }\n    });\n\n  const gpmlsByInteractingGene = {};\n  Object.entries(pathwayIdsByInteractingGene)\n    .forEach(([ixnGene, pathwayIds]) => {\n      gpmlsByInteractingGene[ixnGene] = {};\n      pathwayIds.map(async pathwayId => {\n        const gpml = await fetchGpml(pathwayId);\n        gpmlsByInteractingGene[ixnGene][pathwayId] = gpml;\n      });\n    });\n\n  ideo.gpmlsByInteractingGene = gpmlsByInteractingGene;\n}\n\n/**\n * Get interaction object from a GPML graphics XML element\n *\n * This interaction object connects the searched gene and interacting gene.\n */\nfunction parseInteractionGraphic(graphic, graphIds) {\n  let interaction = null;\n\n  const {searchedGeneGraphIds, matchingGraphIds} = graphIds;\n\n  const endGraphRefs = [];\n  let numMatchingPoints = 0;\n  let isConnectedToSourceGene = false;\n  let ixnType = null;\n  let searchedGeneIndex = null;\n\n  Array.from(graphic.children).forEach(child => {\n    if (child.nodeName !== 'Point') return;\n    const point = child;\n    const graphRef = point.getAttribute('GraphRef');\n    if (graphRef === null) return;\n\n    if (matchingGraphIds.includes(graphRef)) {\n      numMatchingPoints += 1;\n      endGraphRefs.push(graphRef);\n\n      if (searchedGeneGraphIds.includes(graphRef)) {\n        isConnectedToSourceGene = true;\n      }\n\n      if (point.getAttribute('ArrowHead')) {\n        const arrowHead = point.getAttribute('ArrowHead');\n        const isStart = searchedGeneGraphIds.includes(graphRef);\n        if (searchedGeneIndex === null) {\n          searchedGeneIndex = isStart ? 0 : 1;\n        }\n        ixnType = interactionArrowMap[arrowHead][isStart ? 0 : 1];\n      }\n    }\n  });\n\n  if (numMatchingPoints >= 2 && isConnectedToSourceGene) {\n    if (searchedGeneIndex === null) {\n      ixnType = 'interacts with';\n    }\n    ixnType = ixnType[0].toUpperCase() + ixnType.slice(1);\n    const interactionGraphId = graphic.parentNode.getAttribute('GraphId');\n    interaction = {\n      'interactionId': interactionGraphId,\n      'endIds': endGraphRefs,\n      ixnType\n    };\n  }\n\n  return interaction;\n}\n\n/**\n * Get all genes in the given pathway GPML\n */\nexport async function fetchPathwayInteractions(searchedGene, pathwayId, ideo) {\n  const gpml = await fetchGpml(pathwayId);\n  // Gets IDs and elements for searched gene and interacting gene, and,\n  // if they're in any groups, the IDs of those groups\n  const genes = {};\n\n  const nodes = Array.from(gpml.querySelectorAll('DataNode'));\n  nodes.forEach(node => {\n    const label = node.getAttribute('TextLabel');\n    const normLabel = label.toLowerCase();\n    const isKnownGene = normLabel in ideo.geneCache.nameCaseMap;\n    if (isKnownGene) {\n      genes[label] = 1;\n    }\n  });\n\n  const pathwayGenes = Object.keys(genes);\n  const pathwayIxns = {};\n  pathwayGenes.map(gene => {\n    if (gene === searchedGene) return;\n    const gpmls = {};\n    gpmls[pathwayId] = gpml;\n    const summary = summarizeInteractions(\n      gene, searchedGene, [pathwayId], gpmls\n    );\n    pathwayIxns[gene] = (summary ? summary : 'Shares pathway with');\n  });\n\n  return pathwayIxns;\n}\n\n/**\n * Fetch GPML for pathway and find ID of Interaction between two genes,\n * and the ID of the two DataNodes for each of those interactions.\n *\n * WikiPathways SVG isn't detailed enough to reliably determine the specific\n * interaction elements relating two genes, given only the gene symbols.  This\n * fetches augmented GPML data for the pathway, and queries it to get only\n * interactions between the two genes.\n */\nfunction detailInteractions(interactingGene, searchedGene, gpml) {\n\n  // Gets IDs and elements for searched gene and interacting gene, and,\n  // if they're in any groups, the IDs of those groups\n  const [searchedGeneGraphIds, se] = getMatches(gpml, searchedGene);\n  const [interactingGeneGraphIds, ie] = getMatches(gpml, interactingGene);\n\n  const elements = {\n    searchedGene: se,\n    interactingGene: ie\n  };\n\n  const matchingGraphIds =\n    searchedGeneGraphIds.concat(interactingGeneGraphIds);\n  const graphIds = {searchedGeneGraphIds, matchingGraphIds};\n\n  // Get interaction objects that connect the searched and interacting genes\n  const interactions = [];\n  const graphicsXml = gpml.querySelectorAll('Interaction Graphics');\n  Array.from(graphicsXml).forEach(graphic => {\n    const interaction = parseInteractionGraphic(graphic, graphIds);\n    if (interaction !== null) {\n      interaction.elements = elements;\n      interactions.push(interaction);\n    }\n  });\n\n  return interactions;\n}\n\n// export async function fetchInteractionDiagram(annot, descObj, ideo) {\n//   // Fetch raw SVG for pathway diagram\n//   const pathwayId = descObj.pathwayIds[0];\n//   // const baseUrl = 'https://eweitz.github.io/cachome/wikipathways/';\n//   const baseUrl = 'https://cachome.github.io/wikipathways/';\n//   // const baseUrl = 'http://localhost/wikipathways/data/';\n//   const diagramUrl = baseUrl + pathwayId + '.svg';\n//   const response = await fetch(diagramUrl);\n//   if (response.ok) {\n\n//     // console.log('searchedGene', searchedGene)\n\n//     const ixns = await detailInteractions(annot.name, pathwayId, ideo);\n\n//     let selectors = `[name=${annot.name}]`;\n//     let searchedGeneIndex = 0;\n//     let interactingGeneIndex;\n//     if (ixns.length > 0) {\n//       selectors = ixns[0].endIds.map(id => '#' + id).join(',');\n//       searchedGeneIndex = ixns[0].searchedGeneIndex;\n//       interactingGeneIndex = (searchedGeneIndex === 0) ? 1 : 0;\n//     }\n//     // https://webservice.wikipathways.org/findInteractions?query=ACE2&format=json\n\n//     const rawDiagram = await response.text();\n\n//     const pathwayDiagram =\n//       `<div class=\"pathway-diagram\">${rawDiagram}</div>`;\n\n//     annot.displayName += pathwayDiagram;\n\n//     document.querySelector('#_ideogramTooltip').innerHTML =\n//       annot.displayName;\n\n//     Ideogram.d3.select('svg.Diagram')\n//       .attr('width', 350)\n//       .attr('height', 300);\n\n//     const viewport = document.querySelector('.svg-pan-zoom_viewport');\n//     viewport.removeAttribute('style');\n//     viewport.removeAttribute('transform');\n\n//     const matches = document.querySelectorAll(selectors);\n//     console.log('matches', matches)\n//     const match0 = matches[searchedGeneIndex]\n//     const m0 = match0.getCTM();\n//     const m0Rect = match0.getBoundingClientRect();\n//     const m0Box = match0.getBBox();\n//     const m0MinX = m0.e/m0.a;\n//     const m0MinY = m0.f/m0.d;\n\n//     let minX = m0MinX;\n//     let minY = m0MinY;\n//     let width;\n//     let height;\n\n//     width = 350;\n//     height = 300;\n\n//     // matches[0].children[0].setAttribute('fill', '#F55');\n//     match0.children[0].style.fill = '#f55';\n\n//     if (matches.length > 1) {\n//       // console.log('matches.length > 1')\n//       // matches[1].children[0].setAttribute('fill', '#C4C');\n//       const match1 = matches[interactingGeneIndex];\n//       // console.log('match1')\n//       // console.log(match1)\n//       match1.children[0].style.fill = '#c4c';\n//       const m1 = matches[1].getCTM();\n//       const m1Rect = matches[1].getBoundingClientRect();\n//       const m1Box = matches[1].getBBox();\n//       console.log('m0', m0)\n//       console.log('m1', m1)\n//       const m1MinX = m1.e/m1.a;\n//       const m1MinY = m1.f/m1.d;\n//       // const m1MinX = m1.e/m1.a + m1Rect.width;\n//       // const m1MinY = m1.f/m1.d - m1Rect.height;\n//       if (m1MinX < m0MinX) minX = m1MinX;\n//       if (m1MinY < m0MinY) minY = m1MinY;\n\n//       let pairWidth = 0;\n//       if (m0Rect.left < m1Rect.left) {\n//         // pairWidth = m1Rect.right - m0Rect.left;\n//         width += m1Box.width + 40;\n//       }\n\n//       // width += pairWidth;\n\n//       // console.log('m0Rect', m0Rect)\n//       // console.log('m1Rect', m1Rect)\n//       // console.log('m1MinX', m1MinX)\n//       // console.log('m0MinX', m0MinX)\n//       // console.log('m1MinY', m1MinY)\n//       // console.log('m0MinY', m0MinY)\n//       // console.log('pairWidth', pairWidth)\n//       // console.log('width', width)\n//       // width += Math.abs(m1MinX - m0MinX);\n//       // height += Math.abs(m1MinY - m0MinY);\n\n//       // minX -= 100;\n//       // minY -= 100;\n\n//       // minX -= 150;\n//       // minY -= 150;\n//     } else {\n//       minX -= 150;\n//       minY -= 150;\n//     }\n\n//     minX = Math.round(minX);\n//     minY = Math.round(minY);\n//     width = Math.round(width);\n//     height = Math.round(height);\n\n//     const viewBox = `${minX} ${minY} ${width} ${height}`;\n//     console.log('viewBox', viewBox);\n//     document.querySelector('svg.Diagram').setAttribute('viewBox', viewBox);\n\n//   }\n// }\n","/**\n * @fileoverview Kit used in \"Related genes\" example\n *\n * This file simplifies client code for reusing a \"related genes\" ideogram --\n * which finds and displays related genes for a searched gene.\n *\n * Related genes here are either \"interacting genes\" or \"paralogs\".\n * Interacting genes are genes immediately upstream or downstream of the\n * searched gene in a biochemical pathway. Paralogs are evolutionarily\n * similar genes in the same species.\n *\n * Data sources:\n *   - Interacting genes: WikiPathways\n *   - Paralogs: Ensembl\n *   - Genomic coordinates: Ensembl, via MyGene.info\n *\n * Features provided by this module help users discover and explore genes\n * related to their gene of interest.\n *\n * The reference implementation is available at:\n * https://eweitz.github.io/ideogram/related-genes\n */\n\nimport {decompressSync, strFromU8} from 'fflate';\n\nimport {\n  initAnalyzeRelatedGenes, analyzePlotTimes, analyzeRelatedGenes, timeDiff,\n  getRelatedGenesByType, getRelatedGenesTooltipAnalytics\n} from './analyze-related-genes';\nimport {getGeneStructureHtml, addGeneStructureListeners} from './gene-structure';\n\nimport {\n  sortAnnotsByRank, applyRankCutoff, setAnnotRanks,\n} from '../annotations/annotations';\nimport {writeLegend} from '../annotations/legend';\nimport {getAnnotDomId} from '../annotations/process';\nimport {getDir, deepCopy, slug} from '../lib';\nimport {\n  fetchGpmls, summarizeInteractions, fetchPathwayInteractions\n} from './wikipathways';\n// import {drawAnnotsByLayoutType} from '../annotations/draw';\n// import {organismMetadata} from '../init/organism-metadata';\n\n/** Sets DOM IDs for ideo.relatedAnnots; needed to associate labels */\nfunction setRelatedAnnotDomIds(ideo) {\n  const updated = [];\n\n  const sortedChrNames = ideo.chromosomesArray.map((chr) => {\n    return chr.name;\n  });\n\n  ideo.relatedAnnots = applyAnnotsIncludeList(ideo.relatedAnnots, ideo);\n\n  // Count two related annots for same gene as one.\n  // E.g. gene Foo can both interact with and be paralog of gene Bar\n  // Instead of count Foo interacting annot and Foo paralog annot as two,\n  // only count it as one as they are merged in downstream UI.\n  //\n  // Searching STAT3 without this block shows the problem this fixes.\n  const seenNames = {};\n  ideo.relatedAnnots = ideo.relatedAnnots.filter(annot => {\n    if (annot.name in seenNames) {\n      return false;\n    }\n    seenNames[annot.name] = 1;\n    return true;\n  });\n\n  // Arrange related annots by chromosome\n  const annotsByChr = {};\n  ideo.relatedAnnots.forEach((annot) => {\n    if (annot.chr in annotsByChr) {\n      annotsByChr[annot.chr].push(annot);\n    } else {\n      annotsByChr[annot.chr] = [annot];\n    }\n  });\n\n  // Sort related annots by relevance within each chromosome\n  const relevanceSortedAnnotsNamesByChr = {};\n  Object.entries(annotsByChr).map(([chr, annots]) => {\n\n    annots = setAnnotRanks(annots, ideo);\n\n    // Sort so first annots are drawn last, and thus at top layer\n    annots.sort((a, b) => -ideo.annotSortFunction(a, b));\n\n    const annotNames = annots.map((annot) => annot.name);\n    relevanceSortedAnnotsNamesByChr[chr] = annotNames;\n  });\n\n  // annotsByChr.annots.sort((a, b) => {\n  //   // Reverse-sort, so first annots are drawn last, and thus at top layer\n  //   return -ideo.annotSortFunction(a, b);\n  // });\n\n  ideo.relatedAnnots.forEach((annot) => {\n\n    const chr = annot.chr;\n\n    // Annots have DOM IDs keyed by chromosome index and annotation index.\n    // We reconstruct those here using structures built in two blocks above.\n    const chrIndex = sortedChrNames.indexOf(chr);\n    const annotIndex =\n      relevanceSortedAnnotsNamesByChr[chr].indexOf(annot.name);\n\n    annot.domId = getAnnotDomId(chrIndex, annotIndex);\n    updated.push(annot);\n  });\n\n  ideo.relatedAnnots = updated;\n}\n\n/**\n * Determines if interaction node might be a gene\n *\n * Some interaction nodes are biological processes; this filters out many.\n * Filtering these out makes downstream queries faster.\n *\n * ixn {Object} Interaction from WikiPathways\n * gene {Object} Gene from MyGene.info\n */\nfunction maybeGeneSymbol(ixn, gene) {\n  return (\n    ixn !== '' &&\n    !ixn.includes(' ') &&\n    !ixn.includes('/') && // e.g. Akt/PKB\n    ixn.toLowerCase() !== gene.name.toLowerCase()\n  );\n}\n\n// /** Helpful for debugging race conditions caused by concurrency */\n// const sleep = (delay) => {\n//  new Promise((resolve) => setTimeout(resolve, delay));\n// }\n\n/** Reports if interaction node is a gene and not previously seen */\nfunction isInteractionRelevant(rawIxn, gene, nameId, seenNameIds, ideo) {\n  let isGeneSymbol;\n  if ('geneCache' in ideo && gene.name) {\n    isGeneSymbol = rawIxn.toLowerCase() in ideo.geneCache.nameCaseMap;\n  } else {\n    isGeneSymbol = maybeGeneSymbol(rawIxn, gene);\n  }\n\n  return isGeneSymbol && !(nameId in seenNameIds);\n}\n\n/**\n * Retrieves interacting genes from WikiPathways API\n *\n * Docs:\n * https://webservice.wikipathways.org/ui/\n * https://www.wikipathways.org/index.php/Help:WikiPathways_Webservice/API\n *\n * Examples:\n * https://webservice.wikipathways.org/findInteractions?query=ACE2&format=json\n * https://webservice.wikipathways.org/findInteractions?query=RAD51&format=json\n */\nasync function fetchInteractions(gene, ideo) {\n  const ixns = {};\n  const seenNameIds = {};\n  const orgNameSimple = ideo.config.organism.replace(/-/g, ' ');\n  const upperGene = gene.name.toUpperCase();\n\n  let data = {result: []};\n\n  if (ideo.interactionCache) {\n    if (upperGene in ideo.interactionCache) {\n      data = ideo.interactionCache[upperGene];\n    }\n  } else {\n\n    // const queryString = `?query=${gene.name}&format=json`;\n    // const url =\n    //   `https://webservice.wikipathways.org/findInteractions${queryString}`;\n    // const url = `http://localhost:8080/dist/data/cache/${gene.name}.json.gz`;\n    const url = `https://cdn.jsdelivr.net/npm/ixn2/${upperGene}.json.gz`;\n\n    // await sleep(3000);\n\n    const response = await fetch(url);\n    // const data = await response.json();\n\n    if (response.ok) {\n      const blob = await response.blob();\n      const uint8Array = new Uint8Array(await blob.arrayBuffer());\n      data = JSON.parse(strFromU8(decompressSync(uint8Array)));\n    }\n  }\n\n  // For each interaction, get nodes immediately upstream and downstream.\n  // Filter out pathway nodes that are definitely not gene symbols, then\n  // group pathways by gene symbol. Each interacting gene can have\n  // multiple pathways.\n  data.result.forEach(interaction => {\n    if (interaction.species.toLowerCase() === orgNameSimple) {\n      const right = interaction.fields.right.values;\n      const left = interaction.fields.left.values;\n      // let mediator = [];\n      // if ('mediator' in interaction.fields) {\n      //   mediator = interaction.fields.mediator.values;\n      //   console.log('mediator', mediator)\n      // }\n      // const rawIxns = right.concat(left, mediator);\n      const rawIxns = right.concat(left);\n      const name = interaction.name;\n      const id = interaction.id;\n\n      // rawIxns can contain multiple genes, e.g. when\n      // a group (i.e. a complex or a set of paralogs)\n      // interacts with the searched gene\n      const wrappedRawIxns = rawIxns.map(rawIxn => {\n        return {name: rawIxn, color: ''};\n      });\n      const sortedRawIxns =\n        sortAnnotsByRank(wrappedRawIxns, ideo).map(i => i.name);\n\n      sortedRawIxns.forEach(rawIxn => {\n\n        const normRawIxn = rawIxn.toLowerCase();\n\n        // Prevent overwriting searched gene.  Occurs with e.g. human CD4\n        if (normRawIxn.includes(gene.name.toLowerCase())) return;\n\n        // if (rawIxn === '') return; // Avoid oddly blank placeholders\n\n        const nameId = name + id;\n\n        const isRelevant =\n          isInteractionRelevant(normRawIxn, gene, nameId, seenNameIds, ideo);\n\n        if (isRelevant) {\n          seenNameIds[nameId] = 1;\n          const ixn = {name, pathwayId: id};\n          if (normRawIxn in ixns) {\n            ixns[normRawIxn].push(ixn);\n          } else {\n            ixns[normRawIxn] = [ixn];\n          }\n        }\n      });\n    }\n  });\n\n  return ixns;\n}\n\n/**\n * Queries MyGene.info API, returns parsed JSON\n *\n * Docs:\n * https://docs.mygene.info/en/v3/\n *\n * Example:\n * https://mygene.info/v3/query?q=symbol:cdk2%20OR%20symbol:brca1&species=9606&fields=symbol,genomic_pos,name\n */\nasync function fetchMyGeneInfo(queryString) {\n  const myGeneBase = 'https://mygene.info/v3/query';\n  const response = await fetch(myGeneBase + queryString + '&size=400');\n  const data = await response.json();\n  return data;\n}\n\nfunction parseNameAndEnsemblIdFromMgiGene(gene) {\n  const name = gene.name;\n  const id = gene.genomic_pos.ensemblgene;\n  let ensemblId = id;\n  if (typeof id === 'undefined') {\n    // Encountered in AKT3, when querying related genes for MTOR\n    // A 'chr'omosome value containing _ indicates an alt loci scaffold,\n    // so ignore that and take the Ensembl ID associated with the\n    // first position of a primary chromosome.\n    ensemblId =\n      gene.genomic_pos.filter(pos => !pos.chr.includes('_'))[0].ensemblgene;\n  }\n  return {name, ensemblId};\n}\n\n// /**\n//  * Summarizes genes in a pathway\n//  *\n//  * This comprises most of the content for tooltips for pathway genes.\n//  */\n//  function describePathwayGene(pathwayGene, searchedGene, pathway, summary) {\n//   let ixnsDescription = '';\n\n//   const pathwaysBase = 'https://www.wikipathways.org/index.php/Pathway:';\n//   const url = `${pathwaysBase}${pathway.id}`;\n//   const attrs =\n//     `href=\"${url}\" ` +\n//     `target=\"_blank\" ` +\n//     `title=\"See pathway diagram in WikiPathways\"`;\n//   ixnsDescription =\n//     `${summary} ${searchedGene.name} in:</br/>` +\n//     `<a ${attrs}>${pathway.name}</a>`;\n\n//   const {name, ensemblId} = parseNameAndEnsemblIdFromMgiGene(pathwayGene);\n//   const type = 'pathway gene';\n//   const descriptionObj = {\n//     description: ixnsDescription,\n//     ixnsDescription, ensemblId, name, type\n//   };\n//   return descriptionObj;\n// }\n\n/**\n * Summarizes interactions for a gene\n *\n * This comprises most of the content for tooltips for interacting genes.\n */\nfunction describeInteractions(gene, ixns, searchedGene) {\n  const pathwayIds = [];\n  const pathwayNames = [];\n  let ixnsDescription = '';\n\n  if (typeof ixns !== 'undefined') {\n    // ixns is undefined when querying e.g. CDKN1B in human\n    const links = ixns.map(ixn => {\n      // pathwayIds.push(ixn.pathwayId);\n      // pathwayNames.push(ixn.name);\n      // const attrs =\n      //   `class=\"ideo-pathway-link\" ` +\n      //   `title=\"Click to search for other genes in this pathway\" ` +\n      //   `style=\"cursor: pointer\" ` +\n      //   `data-pathway-id=\"${ixn.pathwayId}\" ` +\n      //   `data-pathway-name=\"${ixn.name}\"`;\n      // return `<a ${attrs}>${ixn.name}</a>`;\n\n      const pathwaysBase = 'https://www.wikipathways.org/index.php/Pathway:';\n      const url = `${pathwaysBase}${ixn.pathwayId}`;\n      pathwayIds.push(ixn.pathwayId);\n      pathwayNames.push(ixn.name);\n      const attrs =\n        `class=\"ideo-pathway-link\" ` +\n        `title=\"View in WikiPathways\" ` +\n        `data-pathway-id=\"${ixn.pathwayId}\" ` +\n        `target=\"_blank\" ` +\n        `href=\"${url}\"`;\n      return `<a ${attrs}>${ixn.name}</a>`;\n    }).join('<br/>');\n\n    ixnsDescription =\n      `Interacts with ${searchedGene.name} in:<br/>${links}`;\n  }\n\n  const {name, ensemblId} = parseNameAndEnsemblIdFromMgiGene(gene);\n  const type = 'interacting gene';\n  const descriptionObj = {\n    description: ixnsDescription,\n    ixnsDescription, ensemblId, name, type, pathwayIds, pathwayNames\n  };\n  return descriptionObj;\n}\n\n/** Throw error when searched gene (e.g. \"Foo\") isn't found */\nfunction throwGeneNotFound(geneSymbol, ideo) {\n  const organism = ideo.organismScientificName;\n  throw Error(`\"${geneSymbol}\" is not a known gene in ${organism}`);\n}\n\n/**\n * Fetch genes from cache\n * Construct objects that match format of MyGene.info API response\n */\nfunction fetchGenesFromCache(names, type, ideo) {\n  const cache = ideo.geneCache;\n  const isSymbol = (type === 'symbol');\n  const locusMap = isSymbol ? cache.lociByName : cache.lociById;\n  const nameMap = isSymbol ? cache.idsByName : cache.namesById;\n\n  const hits = names.map(name => {\n\n    const nameLc = name.toLowerCase();\n\n    if (!locusMap[name] && !cache.nameCaseMap[nameLc]) {\n      if (isSymbol) {\n        throwGeneNotFound(name, ideo);\n      } else {\n        return;\n      }\n    }\n\n    // Canonicalize name if it is mistaken in upstream data source.\n    // This can sometimes happen in WikiPathways, e.g. when searching\n    // interactions for rat Pten, it includes a result for \"PIK3CA\".\n    // In that case, this would correct PIK3CA to be Pik3ca.\n    if (isSymbol && !locusMap[name] && cache.nameCaseMap[nameLc]) {\n      name = cache.nameCaseMap[nameLc];\n    }\n\n    const locus = locusMap[name];\n    const symbol = isSymbol ? name : nameMap[name];\n    const ensemblId = isSymbol ? nameMap[name] : name;\n    const fullName = cache.fullNamesById[ensemblId];\n\n    const hit = {\n      symbol,\n      name: fullName,\n      source: 'cache',\n      genomic_pos: {\n        chr: locus[0],\n        start: locus[1],\n        end: locus[2],\n        ensemblgene: ensemblId\n      }\n    };\n\n    return hit;\n  });\n\n  const hitsWithGenomicPos = hits.filter(hit => hit !== undefined);\n\n  return hitsWithGenomicPos;\n}\n\n/** Wait for a certain time (delay) in milliseconds */\nfunction wait(delay) {\n  return new Promise((resolve) => setTimeout(resolve, delay));\n}\n\n/**\n * Get time to wait before retrying a fail service, gracefully\n *\n * The returned wait time helps avoid flooding the server\n */\nfunction exponentialBackoffWithJitter(numFailures, baseWaitMs) {\n  const jitter = 10 * Math.random();\n  return Math.round(baseWaitMs + jitter) * (numFailures ** 2);\n}\n\nasync function retryFetch(requestedThing, numLimit, fn, args) {\n\n  const numFailed = numFailedFetches[requestedThing];\n  if (numFailed > numLimit) {\n    const preamble = 'Failed to fetch from Ideogram third-party service for: ';\n    throw new TypeError(preamble + requestedThing);\n  }\n\n  numFailedFetches[requestedThing] += 1;\n\n  // Exponential backoff\n  const baseWaitMs = 500;\n  const waitMilliseconds = exponentialBackoffWithJitter(numFailed, baseWaitMs);\n\n  console.log(\n    `Failed fetch for ${requestedThing} ${numFailed} times, ` +\n    `retrying in ${waitMilliseconds} ms`\n  );\n\n  await wait(waitMilliseconds);\n  return await fn(...args);\n}\n\n/** Number of times fetches for various things have consecutively failed */\nconst numFailedFetches = {\n  genes: 0\n};\n\n/** Fetch genes from cache, or, if needed, from MyGene.info API */\nasync function fetchGenes(names, type, ideo) {\n\n  let data;\n\n  // Account for single-gene fetch\n  if (typeof names === 'string') names = [names];\n\n  // Query parameter for MyGene.info API\n  const qParam = names.map(name => `${type}:${name.trim()}`).join(' OR ');\n  const taxid = ideo.config.taxid;\n\n  const queryStringBase = `?q=${qParam}&species=${taxid}&fields=`;\n\n  if (ideo.geneCache) {\n    const hits = fetchGenesFromCache(names, type, ideo);\n\n    // Asynchronously fetch full name, but don't await the response, because\n    // full names are only shown upon hovering over an annotation.\n    hits.forEach((hit) => {\n      const symbol = hit.symbol;\n      const fullName = hit.name;\n      if (symbol in ideo.annotDescriptions.annots) {\n        ideo.annotDescriptions.annots[symbol].name = fullName;\n      } else {\n        ideo.annotDescriptions.annots[symbol] = {name: fullName};\n      }\n    });\n\n    data = {hits, fromGeneCache: true};\n  } else {\n    // Fetch gene data from MyGene.info\n    const queryString = `${queryStringBase}symbol,genomic_pos,name`;\n    try {\n      data = await fetchMyGeneInfo(queryString);\n    } catch (error) {\n      const isFailedFetch = (error.message === 'Failed to fetch');\n      if (isFailedFetch && navigator.onLine) {\n        // Retry fetching 3 times, waiting longer each time\n        data = await retryFetch('genes', 3, fetchGenes, [names, type, ideo]);\n      }\n    }\n  }\n\n  return data;\n}\n\n/**\n * Retrieves position and other data on interacting genes from MyGene.info\n */\nasync function fetchInteractionAnnots(interactions, searchedGene, ideo) {\n\n  const annots = [];\n  const symbols = Object.keys(interactions);\n\n  if (symbols.length === 0) return annots;\n\n  const data = await fetchGenes(symbols, 'symbol', ideo);\n\n  data.hits.forEach(gene => {\n    // If hit lacks position\n    // or is same as searched gene (e.g. search for human SRC),\n    // then skip processing\n    if (\n      'genomic_pos' in gene === false ||\n      gene.symbol === searchedGene.name\n    ) {\n      return;\n    }\n\n    const annot = parseAnnotFromMgiGene(gene, ideo, 'purple');\n    annots.push(annot);\n\n    const ixns = interactions[gene.symbol.toLowerCase()];\n\n    const descriptionObj = describeInteractions(gene, ixns, searchedGene);\n\n    mergeDescriptions(annot, descriptionObj, ideo);\n  });\n\n  // Fetch GPML files to use when updating interaction descriptions with\n  // refined direction.\n  fetchGpmls(ideo);\n\n  return annots;\n}\n\n/** Fetch paralog positions from MyGeneInfo */\nasync function fetchParalogPositionsFromMyGeneInfo(\n  homologs, searchedGene, ideo\n) {\n  const annots = [];\n\n  const cached = homologs.length && typeof homologs[0] === 'string';\n  const ensemblIds = cached ? homologs : homologs.map(homolog => homolog.id);\n  const data = await fetchGenes(ensemblIds, 'ensemblgene', ideo);\n\n  data.hits.forEach(gene => {\n\n    // If hit lacks position, skip processing\n    if ('genomic_pos' in gene === false) return;\n    if ('name' in gene === false) return;\n\n    const annot = parseAnnotFromMgiGene(gene, ideo, 'pink');\n    annots.push(annot);\n\n    const description = `Paralog of ${searchedGene.name}`;\n    const {name, ensemblId} = parseNameAndEnsemblIdFromMgiGene(gene);\n    const type = 'paralogous gene';\n    const descriptionObj = {description, ensemblId, name, type};\n    mergeDescriptions(annot, descriptionObj, ideo);\n  });\n\n  return annots;\n}\n\nfunction overplotParalogs(annots, ideo) {\n  if (!ideo.config.showParalogNeighborhoods) return;\n\n  annots = applyAnnotsIncludeList(annots, ideo);\n\n  if (annots.length < 2) return;\n\n  // Arrays of paralogs within 10 Mbp of each other\n  const neighborhoods = {};\n\n  neighborhoods[annots[0].chr] = {};\n  neighborhoods[annots[0].chr][annots[0].start] = [annots[0]];\n\n  const windowInt = 2_000_000;\n  const windowProse = '2 Mbp';\n\n  for (let i = 1; i < annots.length; i++) {\n    const annot = annots[i];\n    const chr = annot.chr;\n    const start = annot.start;\n    if (chr in neighborhoods) {\n      const starts = Object.keys(neighborhoods[chr]);\n      for (let j = 0; j < starts.length; j++) {\n        const startJInt = parseInt(starts[j]);\n        if (Math.abs(start - startJInt) < windowInt) {\n          neighborhoods[chr][startJInt].push(annot);\n        } else {\n          neighborhoods[chr][start] = [annot];\n        }\n      }\n    } else {\n      neighborhoods[chr] = {};\n      neighborhoods[chr][start] = [annot];\n    }\n  }\n\n  // Big enough to see and hover\n  const overlayAnnotLength = 15_000_000;\n\n  const searchedGene = getSearchedFromDescriptions(ideo);\n\n  const neighborhoodAnnots =\n    Object.entries(neighborhoods).map(([chr, neighborhood], index) => {\n      const start = parseInt(Object.keys(neighborhood)[0]);\n      let paralogs = Object.values(neighborhood)[0];\n\n      if (paralogs.length < 2) {\n        return {paralogs};\n      }\n\n      // paralogs.map(paralog => {\n      //   console.log(paralog);\n      // })\n\n      const description =\n        `${paralogs.length} nearby paralogs of ${searchedGene}`;\n\n      const chrLength = ideo.chromosomes[ideo.config.taxid][chr].bpLength;\n      let annotStart = start - overlayAnnotLength/2;\n      let annotStop = start + overlayAnnotLength/2;\n      if (annotStop > chrLength) {\n        annotStart = start - overlayAnnotLength;\n        annotStop = chrLength;\n      } else if (annotStart < 1) {\n        annotStart = 1;\n        annotStop = overlayAnnotLength;\n      };\n\n      if ('geneCache' in ideo) {\n        paralogs = paralogs.map(paralog => {\n          paralog.fullName = ideo.geneCache.fullNamesById[paralog.id];\n          return paralog;\n        });\n      }\n\n      const key = 'paralogNeighborhood-' + index;\n      const fStart = start.toLocaleString(); // Format for readability\n      const displayCoordinates = `chr${chr}:${fStart} ± ${windowProse}`;\n\n      const annot = {\n        name: key,\n        chr,\n        start: annotStart,\n        stop: annotStop,\n        color: 'pink',\n        description,\n        paralogs,\n        type: 'paralog neighborhood',\n        displayCoordinates\n      };\n\n      ideo.annotDescriptions.annots[annot.name] = annot;\n      return annot;\n    }).filter(n => n.paralogs.length > 1);\n\n  if (neighborhoodAnnots.length > 0) {\n    // console.log('neighborhoodAnnots')\n    // console.log(neighborhoodAnnots.map(na => na));\n    ideo.drawAnnots(neighborhoodAnnots, 'overlay', true, true);\n    moveLegend();\n  }\n}\n\n/**\n * Fetch paralogs of searched gene\n */\nasync function fetchParalogs(annot, ideo) {\n  const taxid = ideo.config.taxid;\n\n  let homologs;\n  // Fetch paralogs\n  if (ideo.paralogCache) {\n    // const baseUrl = 'http://localhost:8080/dist/data/cache/paralogs/';\n    // const url = `${baseUrl}homo-sapiens/${annot.name}.tsv`;\n    // const response = await fetch(url);\n    // const oneRowTsv = await response.text();\n    // const rawHomologEnsemblIds = oneRowTsv.split('\\t');\n    // homologs = rawHomologEnsemblIds.map(r => getEnsemblId('ENSG', r));\n    const paralogsByName = ideo.paralogCache.paralogsByName;\n    const nameUc = annot.name.toUpperCase();\n    const hasParalogs = nameUc in paralogsByName;\n    homologs = hasParalogs ? paralogsByName[nameUc] : [];\n  } else {\n    const params = `&format=condensed&type=paralogues&target_taxon=${taxid}`;\n    const path = `/homology/id/${annot.id}?${params}`;\n    const ensemblHomologs = await Ideogram.fetchEnsembl(path);\n    homologs = ensemblHomologs.data[0].homologies;\n  }\n\n\n  // Fetch positions of paralogs\n  let annots =\n    await fetchParalogPositionsFromMyGeneInfo(homologs, annot, ideo);\n\n  // Omit genes named like \"AC113554.1\", which is an \"accession.version\".\n  // Such accVers are raw and poorly suited here.\n  annots = annots.filter(annot => {\n    const isAccVer = annot.name.match(/^AC[0-9.]+$/);\n    return !isAccVer;\n  });\n\n  return annots;\n}\n\n/**\n * Filters out placements on alternative loci scaffolds, an advanced\n * genome assembly feature we are not concerned with in ideograms.\n *\n * Example:\n * https://mygene.info/v3/query?q=symbol:PTPRC&species=9606&fields=symbol,genomic_pos,name\n */\nfunction getGenomicPos(gene, ideo) {\n  let genomicPos = null;\n  if (Array.isArray(gene.genomic_pos)) {\n    genomicPos = gene.genomic_pos.filter(pos => {\n      return pos.chr in ideo.chromosomes[ideo.config.taxid];\n    })[0];\n  } else {\n    genomicPos = gene.genomic_pos;\n  }\n  return genomicPos;\n}\n\n/**\n * Transforms MyGene.info (MGI) gene into Ideogram annotation\n */\nfunction parseAnnotFromMgiGene(gene, ideo, color='red') {\n  const genomicPos = getGenomicPos(gene, ideo);\n\n  const annot = {\n    name: gene.symbol,\n    chr: genomicPos.chr,\n    start: genomicPos.start,\n    stop: genomicPos.end,\n    id: genomicPos.ensemblgene,\n    color\n  };\n\n  return annot;\n}\n\nfunction moveLegend() {\n  const ideoInnerDom = document.querySelector('#_ideogramInnerWrap');\n  const decorPad = setRelatedDecorPad({}).legendPad;\n  const left = decorPad + 20;\n  const legendStyle = `position: absolute; top: 15px; left: ${left}px`;\n  const legend = document.querySelector('#_ideogramLegend');\n  ideoInnerDom.prepend(legend);\n  legend.style = legendStyle;\n}\n\n/** Filter annotations to only include those in configured list */\nfunction applyAnnotsIncludeList(annots, ideo) {\n\n  if (ideo.config.annotsInList === 'all') return annots;\n\n  const includedAnnots = [];\n  annots.forEach(annot => {\n    if (ideo.config.annotsInList.includes(annot.name.toLowerCase())) {\n      includedAnnots.push(annot);\n    }\n  });\n  return includedAnnots;\n}\n\n/** Fetch and draw interacting genes, return Promise for annots */\nfunction processInteractions(annot, ideo) {\n  return new Promise(async (resolve) => {\n    const t0 = performance.now();\n\n    const interactions = await fetchInteractions(annot, ideo);\n    const annots = await fetchInteractionAnnots(interactions, annot, ideo);\n\n    ideo.relatedAnnots.push(...annots);\n    finishPlotRelatedGenes('interacting', ideo);\n\n    ideo.time.rg.interactions = timeDiff(t0);\n\n    resolve();\n  });\n}\n\n/** Find and draw paralogs, return Promise for annots */\nfunction processParalogs(annot, ideo) {\n  return new Promise(async (resolve) => {\n    const t0 = performance.now();\n\n    const annots = await fetchParalogs(annot, ideo);\n    ideo.relatedAnnots.push(...annots);\n    finishPlotRelatedGenes('paralogous', ideo);\n    overplotParalogs(annots, ideo);\n\n    ideo.time.rg.paralogs = timeDiff(t0);\n\n    resolve();\n  });\n}\n\n// /**\n//  * Sorts gene names consistently.\n//  *\n//  * Might also loosely rank by first-discovered or most prominent\n//  */\n// function sortGeneNames(aName, bName) {\n//   // Rank shorter names above longer names\n//   if (bName.length !== aName.length) return bName.length - aName.length;\n\n//   // Rank names of equal length alphabetically\n//   return [aName, bName].sort().indexOf(aName) === 0 ? 1 : -1;\n// }\n\n/** Sorts by relevance of related type, then rank */\nexport function sortByRelatedType(a, b) {\n  var aName, bName, aColor, bColor;\n  if ('name' in a) {\n    // Locally processed annotations\n    aName = a.name;\n    bName = b.name;\n    aColor = a.color;\n    bColor = b.color;\n  } else {\n    // Raw annotations\n    [aName, aColor] = [a[0], a[3]];\n    [bName, bColor] = [b[0], b[3]];\n  }\n\n  // Rank red (searched gene) highest\n  if (aColor === 'red') return -1;\n  if (bColor === 'red') return 1;\n\n  // Rank purple (interacting gene) above pink (paralogous gene)\n  if (aColor === 'purple' && bColor === 'pink') return -1;\n  if (bColor === 'purple' && aColor === 'pink') return 1;\n\n  return a.rank - b.rank;\n\n  // return sortGeneNames(aName, bName);\n}\n\nfunction mergeDescriptions(annot, desc, ideo) {\n  let mergedDesc;\n  const descriptions = ideo.annotDescriptions.annots;\n\n  if (annot.name in descriptions) {\n    const otherDesc = descriptions[annot.name];\n    mergedDesc = desc;\n    if (desc.type === otherDesc.type) return;\n    Object.keys(otherDesc).forEach(function(key) {\n      if (key in mergedDesc === false) {\n        mergedDesc[key] = otherDesc[key];\n      }\n    });\n    // Object.assign({}, descriptions[annot.name]);\n    if ('type' in otherDesc) {\n      mergedDesc.type += ', ' + otherDesc.type;\n      mergedDesc.description += `<br/><br/>${otherDesc.description}`;\n    }\n  } else {\n    mergedDesc = desc;\n  }\n\n  ideo.annotDescriptions.annots[annot.name] = mergedDesc;\n}\n\nfunction mergeAnnots(unmergedAnnots) {\n\n  const seenAnnots = {};\n  let mergedAnnots = [];\n\n  unmergedAnnots.forEach((annot) => {\n    if (annot.name in seenAnnots === false) {\n      mergedAnnots.push(annot);\n      seenAnnots[annot.name] = 1;\n    } else {\n      if (annot.color === 'purple') {\n        mergedAnnots = mergedAnnots.map((mergedAnnot) => {\n          return (annot.name === mergedAnnot.name) ? annot : mergedAnnot;\n        });\n      }\n    }\n  });\n\n  return mergedAnnots;\n}\n\n/** Filter, sort, draw annots.  Move legend. */\nfunction finishPlotRelatedGenes(type, ideo) {\n  setRelatedAnnotDomIds(ideo);\n\n  let annots = deepCopy(ideo.relatedAnnots);\n\n  annots = applyAnnotsIncludeList(annots, ideo);\n  annots = mergeAnnots(annots);\n\n  // annots = applyRankCutoff(annots, 40, ideo);\n  ideo.relatedAnnots = mergeAnnots(annots);\n  // ideo.relatedAnnots = applyRankCutoff(annots, 40, ideo);\n  // annots.sort(sortByRelatedType);\n  ideo.relatedAnnots.sort(ideo.annotSortFunction);\n\n  // ideo.relatedAnnots = ideo.relatedAnnots.slice(0, 40);\n\n  if (annots.length > 1 && ideo.onFindGenesCallback) {\n    ideo.onFindGenesCallback();\n  }\n\n  ideo.drawAnnots(annots);\n  // const idsToRemove = annots.slice(40).map(a => a.domId);\n  // if (idsToRemove.length > 0) {\n  //   const selector = '#' + idsToRemove.join(',#')\n  //   document.querySelectorAll(selector).forEach(el => el.remove());\n  // }\n\n  if (ideo.config.showAnnotLabels) {\n    ideo.fillAnnotLabels(ideo.relatedAnnots);\n  }\n\n  moveLegend();\n\n  analyzePlotTimes(type, ideo);\n}\n\n/** Fetch position of searched gene, return corresponding annotation */\nasync function processSearchedGene(geneSymbol, ideo) {\n  const t0 = performance.now();\n\n  const data = await fetchGenes(geneSymbol, 'symbol', ideo);\n\n  if (data.hits.length === 0) {\n    return;\n  }\n  const gene = data.hits.find(hit => {\n    const genomicPos = getGenomicPos(hit, ideo); // omits alt loci\n    return genomicPos && genomicPos.ensemblgene;\n  });\n  const ensemblId = gene.genomic_pos.ensemblgene;\n\n  // Assign tooltip content.  Much of the content is often retrieved from\n  // the gene cache.  In that case, all fields except `name` are fetched\n  // from cache.  Occasionally, e.g. often upon the very first search, no\n  // content is yet available from cache.\n  let desc = {description: '', ensemblId, type: 'searched gene'};\n  if (gene.symbol in ideo.annotDescriptions.annots) {\n    // Most content already set via cache.\n    // `name` will be set via non-blocking part of `fetchGenes`.\n    const oldDesc = ideo.annotDescriptions.annots[gene.symbol];\n    desc = Object.assign(oldDesc, desc);\n  } else {\n    // No content has been set yet via cache.  In this case, `gene` already\n    // has all the data needed for the searched gene's tooltip content.\n    desc.name = gene.name;\n  }\n\n  ideo.annotDescriptions.annots[gene.symbol] = desc;\n\n  const annot = parseAnnotFromMgiGene(gene, ideo);\n\n  ideo.relatedAnnots.push(annot);\n\n  ideo.time.rg.searchedGene = timeDiff(t0);\n\n  return annot;\n}\n\nfunction adjustPlaceAndVisibility(ideo) {\n  var ideoContainerDom = document.querySelector(ideo.config.container);\n\n  ideoContainerDom.style.visibility = '';\n  ideoContainerDom.style.position = 'absolute';\n  ideoContainerDom.style.width = '100%';\n\n  var ideoInnerDom = document.querySelector('#_ideogramInnerWrap');\n  ideoInnerDom.style.position = 'relative';\n  ideoInnerDom.style.marginLeft = 'auto';\n  ideoInnerDom.style.marginRight = 'auto';\n  ideoInnerDom.style.overflowY = 'hidden';\n  document.querySelector('#_ideogramMiddleWrap').style.overflowY = 'hidden';\n\n  const legendPad = ideo.config.legendPad;\n\n  if (typeof ideo.didAdjustIdeogramLegend === 'undefined') {\n    // Accounts for moving legend when external content at left or right\n    // is variable upon first rendering plotted genes\n\n    var ideoDom = document.querySelector('#_ideogram');\n    const legendWidth = 160;\n    ideoInnerDom.style.maxWidth =\n      (\n        parseInt(ideoInnerDom.style.maxWidth) +\n        legendWidth +\n        legendPad\n      ) + 'px';\n\n    ideoDom.style.minWidth =\n      (parseInt(ideoDom.style.minWidth) + legendPad) + 'px';\n    ideoDom.style.maxWidth =\n      (parseInt(ideoDom.style.minWidth) + legendPad) + 'px';\n    ideoDom.style.position = 'relative';\n    ideoDom.style.left = legendWidth + 'px';\n\n    ideo.didAdjustIdeogramLegend = true;\n  }\n}\n\n// function sortByPathwayIxn(a, b) {\n//   const aColor = a.color;\n//   const bColor = b.color;\n\n//   // Rank red (searched gene) highest\n//   if (aColor === 'red') return -1;\n//   if (bColor === 'red') return 1;\n\n//   // Rank not grey above grey\n//   if (aColor === 'grey' && bColor !== 'grey') return 1;\n//   if (bColor === 'grey' && aColor !== 'grey') return -1;\n\n//   return a.rank - b.rank;\n// }\n\n// async function fetchPathwayGeneAnnots(searchedGene, pathway, ideo) {\n//   const annots = [];\n\n//   const pathwayIxns =\n//     await fetchPathwayInteractions(searchedGene.name, pathway.id, ideo);\n\n//   const pathwayGenes = Object.keys(pathwayIxns);\n//   const data = await fetchGenes(pathwayGenes, 'symbol', ideo);\n\n//   const ixnColors = {\n//     'Stimulates': 'green',\n//     'Stimulated by': 'green',\n//     'Necessarily stimulates': 'green',\n//     'Necessarily stimulated by': 'green',\n//     'Transcribes / translates': 'brown',\n//     'Transcribed / translated by': 'brown',\n//     'Inhibits': 'red',\n//     'Inhibited by': 'red',\n//     'Modifies': 'blue',\n//     'Modified by': 'blue',\n//     'Acts on': 'blue',\n//     'Acted on by': 'blue',\n//     'Catalyzes': 'orange',\n//     'Catalyzed by': 'orange',\n//     'Converts': 'orange',\n//     'Converted by': 'orange',\n//     'Binds': 'black',\n//     'Shares pathway with': 'grey'\n//   };\n\n//   data.hits.forEach(gene => {\n//     // If hit lacks position\n//     // or is same as searched gene (e.g. search for human SRC),\n//     // then skip processing\n//     if (\n//       'genomic_pos' in gene === false ||\n//       gene.symbol === searchedGene.name\n//     ) {\n//       return;\n//     }\n\n//     // Account for edge case: cyclic AMP (cAMP) is not \"CAMP\" gene\n//     if (gene.symbol === 'cAMP') return;\n\n//     const summary = pathwayIxns[gene.symbol];\n//     const color = ixnColors[summary];\n//     // if (color !== 'blue') console.log(gene);\n\n//     const annot = parseAnnotFromMgiGene(gene, ideo, color);\n//     annots.push(annot);\n\n//     const descriptionObj =\n//       describePathwayGene(gene, searchedGene, pathway, summary);\n\n//     mergeDescriptions(annot, descriptionObj, ideo);\n//   });\n\n//   ideo.annotSortFunction = sortByPathwayIxn;\n\n//   const sortedAnnots = annots.sort(sortByPathwayIxn).slice(0, 40);\n\n//   return sortedAnnots;\n// }\n\n// /**\n//  *\n//  */\n// async function plotPathwayGenes(searchedGene, pathway, ideo) {\n//   const headerTitle = 'Genes in pathway';\n//   initAnnotDescriptions(ideo, headerTitle);\n\n//   legendPathwayName = pathway.name;\n//   ideo.config.legend = pathwayLegend;\n//   writeLegend(ideo);\n//   moveLegend();\n\n//   ideo.relatedAnnots = [];\n\n//   await processSearchedGene(searchedGene.name, ideo);\n\n//   const annots = await fetchPathwayGeneAnnots(searchedGene, pathway, ideo);\n//   ideo.relatedAnnots.push(...annots);\n//   finishPlotRelatedGenes('pathway', ideo);\n// }\n\nfunction initAnnotDescriptions(ideo, headerTitle) {\n  const organism = ideo.getScientificName(ideo.config.taxid);\n  const version = Ideogram.version;\n  const headers = [\n    `# ${headerTitle}`,\n    `# Organism: ${organism}`,\n    `# Generated by Ideogram.js version ${version}, https://github.com/eweitz/ideogram`,\n    `# Generated at ${window.location.href}`\n  ].join('\\n');\n\n  delete ideo.annotDescriptions;\n  ideo.annotDescriptions = {headers, annots: {}};\n\n}\n\n/**\n * For given gene, finds and draws interacting genes and paralogs\n *\n * @param geneSymbol {String} Gene symbol, e.g. RAD51\n */\nasync function plotRelatedGenes(geneSymbol=null) {\n\n  const ideo = this;\n\n  if (!geneSymbol) {\n    return plotGeneHints(ideo);\n  }\n\n  ideo.clearAnnotLabels();\n  const legend = document.querySelector('#_ideogramLegend');\n  if (legend) legend.remove();\n\n  ideo.config = setRelatedDecorPad(ideo.config);\n\n  initAnnotDescriptions(ideo, `Related genes for ${geneSymbol}`);\n\n  const ideoSel = ideo.selector;\n  const annotSel = ideoSel + ' .annot';\n  document.querySelectorAll(annotSel).forEach(el => el.remove());\n\n  ideo.startHideAnnotTooltipTimeout();\n\n  // Refine style\n  document.querySelectorAll('.chromosome').forEach(chromosome => {\n    chromosome.style.cursor = '';\n  });\n\n  adjustPlaceAndVisibility(ideo);\n\n  ideo.relatedAnnots = [];\n\n  // Fetch positon of searched gene\n  const annot = await processSearchedGene(geneSymbol, ideo);\n\n  if (typeof annot === 'undefined') throwGeneNotFound(geneSymbol, ideo);\n\n  ideo.config.legend = relatedLegend;\n  writeLegend(ideo);\n  moveLegend();\n\n  await Promise.all([\n    processInteractions(annot, ideo),\n    processParalogs(annot, ideo)\n  ]);\n\n  ideo.time.rg.total = timeDiff(ideo.time.rg.t0);\n\n  analyzeRelatedGenes(ideo);\n\n  if (ideo.onPlotFoundGenesCallback) ideo.onPlotFoundGenesCallback();\n}\n\nfunction getAnnotByName(annotName, ideo) {\n  var annotByName;\n  ideo.annots.forEach(annotsByChr => {\n    annotsByChr.annots.forEach(annot => {\n      if (annotName === annot.name) {\n        annotByName = annot;\n      }\n    });\n  });\n\n  if (annotByName === null) {\n    annotByName = ideo.annotDescriptions.annots[annotName];\n  }\n  return annotByName;\n}\n\n/**\n * Manage click on pathway links in annotation tooltips\n */\n// function managePathwayClickHandlers(searchedGene, ideo) {\n//   setTimeout(function() {\n//     const pathways = document.querySelectorAll('.ideo-pathway-link');\n//     if (pathways.length > 0 && !ideo.addedPathwayClickHandler) {\n//       pathways.forEach(pathway => {\n//         // pathway.removeEventListener('click', handlePathwayClick);\n//         pathway.addEventListener('click', function(event) {\n//           const target = event.target;\n//           const pathwayId = target.getAttribute('data-pathway-id');\n//           const pathwayName = target.getAttribute('data-pathway-name');\n//           const pathway = {id: pathwayId, name: pathwayName};\n//           plotPathwayGenes(searchedGene, pathway, ideo);\n//         });\n//       });\n\n//       // Ensures handler isn't added redundantly.  This is used because\n//       // addEventListener options like {once: true} don't suffice\n//       // ideo.addedPathwayClickHandler = true;\n//     }\n//   }, 100);\n// }\n\nfunction onDidShowAnnotTooltip() {\n  const ideo = this;\n  handleTooltipClick(ideo);\n  addGeneStructureListeners(ideo);\n}\n\n/**\n * Handles click within annotation tooltip\n *\n * Makes clicking link in tooltip behave same as clicking annotation\n */\nexport function handleTooltipClick(ideo) {\n  // const tooltip = document.querySelector('._ideogramTooltip');\n  // if (!ideo.addedTooltipClickHandler) {\n  //   tooltip.addEventListener('click', () => {\n  //     const geneDom = document.querySelector('#ideo-related-gene');\n  //     const annotName = geneDom.textContent;\n  //     const annot = getAnnotByName(annotName, ideo);\n  //     ideo.onClickAnnot(annot);\n  //   });\n\n  //   // Ensures handler isn't added redundantly.  This is used because\n  //   // addEventListener options like {once: true} don't suffice\n  //   ideo.addedTooltipClickHandler = true;\n  // }\n\n  const tooltip = document.querySelector('._ideogramTooltip');\n  if (!ideo.addedTooltipClickHandler) {\n    tooltip.addEventListener('click', (event) => {\n      if (['input', 'label'].includes(event.target.localName)) {\n        return;\n      }\n\n      let geneDom = document.querySelector('#ideo-related-gene');\n      if (!geneDom) {\n        geneDom = event.target;\n      }\n      const annotName = geneDom.textContent;\n      const annot = getAnnotByName(annotName, ideo);\n\n      ideo.onClickAnnot(annot);\n    });\n\n    // Ensures handler isn't added redundantly.  This is used because\n    // addEventListener options like {once: true} don't suffice\n    ideo.addedTooltipClickHandler = true;\n  }\n}\n\n/** Return searched gene from annotation descriptions in Ideogram object */\nfunction getSearchedFromDescriptions(ideo) {\n  return (\n    Object.entries(ideo.annotDescriptions.annots)\n      .find(([k, v]) => v.type === 'searched gene')[0]\n  );\n}\n\nfunction decorateInteractingGene(annot, descObj, ideo) {\n  if ('type' in descObj && descObj.type.includes('interacting gene')) {\n    const pathwayIds = descObj.pathwayIds;\n    // Get symbol of the searched gene, e.g. \"PTEN\"\n    const searchedGene = getSearchedFromDescriptions(ideo);\n\n    const gpmls = ideo.gpmlsByInteractingGene[annot.name];\n\n    const summary =\n      summarizeInteractions(annot.name, searchedGene, pathwayIds, gpmls);\n    if (summary !== null) {\n      const oldSummary = 'Interacts with';\n      descObj.description =\n        descObj.description.replace(oldSummary, summary);\n    }\n  }\n\n  return descObj;\n}\n\nfunction decorateParalogNeighborhood(annot, descObj, style) {\n  // Rank 1st highest, then put it last as it already has a triangle\n  // annotation, and is often also labeled.\n  const sortedParalogs =\n    descObj.paralogs.sort((a, b) => a.rank - b.rank);\n  const firstRanked = sortedParalogs.shift(); // Take off first\n  sortedParalogs.push(firstRanked); // Make it last\n\n  const originalDisplay =\n    'Paralog neighborhood<br/>' +\n    '<br/>' +\n    descObj.description + ':<br/>' +\n    `${sortedParalogs\n      .map(paralog => {\n        let title = '';\n        if (paralog.fullName) title = paralog.fullName;\n        if (paralog.rank) {\n          const rank = paralog.rank;\n          title += ` &#013;Ranked ${rank} in general or scholarly interest`;\n        }\n        if (title !== '') title = `title=\"${title}\"`;\n        return (\n          `<span class=\"ideo-paralog-neighbor\" ${title} ${style}'>${\n            paralog.name\n          }</span>`\n        );\n      }).join('<br/>')}` +\n    '<br/>';\n  annot.displayCoordinates = descObj.displayCoordinates;\n\n  return [annot, originalDisplay];\n}\n\n/**\n * Enhance tooltip shown on hovering over gene annotation\n */\nfunction decorateAnnot(annot) {\n  const ideo = this;\n  if (\n    annot.name === ideo.prevClickedAnnot?.name &&\n    ideo.isTooltipCooling\n  ) {\n    // Cancels showing tooltip immediately after clicking gene\n    return null;\n  }\n\n  let descObj = ideo.annotDescriptions.annots[annot.name];\n\n  if (ideo.config.relatedGenesMode === 'related') {\n    descObj = decorateInteractingGene(annot, descObj, ideo);\n  }\n\n  const description =\n    descObj.description.length > 0 ? `<br/>${descObj.description}` : '';\n  const fullName = descObj.name;\n  const style = 'style=\"color: #0366d6; cursor: pointer;\"';\n\n  let fullNameAndRank = fullName;\n  if ('rank' in annot) {\n    const rank = 'Ranked ' + annot.rank + ' in general or scholarly interest';\n    fullNameAndRank = `<span title=\"${rank}\">${fullName}</span>`;\n  }\n\n  const isParalogNeighborhood = annot.name.includes('paralogNeighborhood');\n\n  const geneStructureHtml = getGeneStructureHtml(\n    annot, ideo, isParalogNeighborhood\n  );\n\n  let originalDisplay =\n    `<span id=\"ideo-related-gene\" ${style}>${annot.name}</span><br/>` +\n    `${fullNameAndRank}<br/>` +\n    description +\n    geneStructureHtml +\n    `<br/>`;\n\n  if (isParalogNeighborhood) {\n    [annot, originalDisplay] =\n      decorateParalogNeighborhood(annot, descObj, style);\n  }\n\n  annot.displayName = originalDisplay;\n\n  // managePathwayClickHandlers(annot, ideo);\n\n  return annot;\n}\n\nconst shape = 'triangle';\n\nfunction getLegendName(nameText) {\n  const legendHeaderStyle =\n    `font-size: 14px; font-weight: bold; font-color: #333;`;\n\n  return `\n    <div style=\"position: relative; left: 30px;\">\n      <div style=\"${legendHeaderStyle}\">${nameText}</div>\n      <i>Click gene to search</i>\n    </div>\n  `;\n}\n\nconst relatedLegend = [{\n  name: getLegendName('Related genes'),\n  nameHeight: 50,\n  rows: [\n    {name: 'Interacting gene', color: 'purple', shape: shape},\n    {name: 'Paralogous gene', color: 'pink', shape: shape},\n    {name: 'Searched gene', color: 'red', shape: shape}\n  ]\n}];\n\nlet legendPathwayName = '';\n\nconst pathwayLegend = [{\n  name: getLegendName('Related genes'),\n  nameHeight: 50,\n  rows: [\n    {name: 'Pathway gene', color: 'blue', shape: shape},\n    {name: 'Searched gene', color: 'red', shape: shape}\n  ]\n}];\n\nconst citedLegend = [{\n  name: getLegendName('Highly cited genes'),\n  nameHeight: 30,\n  rows: []\n}];\n\n/** Sets legendPad for related genes view */\nfunction setRelatedDecorPad(kitConfig) {\n  kitConfig.legendPad = kitConfig.showAnnotLabels ? 70 : 30;\n  return kitConfig;\n}\n\nconst globalKitDefaults = {\n  chrWidth: 9,\n  chrHeight: 100,\n  chrLabelSize: 12,\n  annotationHeight: 7,\n  showFullyBanded: false,\n  rotatable: false,\n  legend: relatedLegend,\n  chrBorderColor: '#333',\n  chrLabelColor: '#333',\n  onWillShowAnnotTooltip: decorateAnnot,\n  onDidShowAnnotTooltip,\n  showTools: true,\n  showAnnotLabels: true,\n  chrFillColor: {centromere: '#DAAAAA'}\n};\n\nfunction plotGeneHints() {\n  const ideo = this;\n\n  if (!ideo || 'annotDescriptions' in ideo) return;\n\n  ideo.annotDescriptions = {annots: {}};\n\n  ideo.flattenAnnots().map((annot) => {\n    let description = [];\n    if ('significance' in annot && annot.significance !== 'n/a') {\n      description.push(annot.significance);\n    }\n    if ('citations' in annot && annot.citations !== undefined) {\n      description.push(annot.citations);\n    }\n    description = description.join('<br/><br/>');\n    ideo.annotDescriptions.annots[annot.name] = {\n      description,\n      name: annot.fullName\n    };\n  });\n\n  adjustPlaceAndVisibility(ideo);\n  moveLegend();\n  ideo.fillAnnotLabels([]);\n  const container = ideo.config.container;\n  document.querySelector(container).style.visibility = '';\n}\n\n/**\n * Wrapper for Ideogram constructor, with generic \"Related genes\" options\n *\n * This function is made available as a static method on Ideogram.\n *\n * @param {Object} config Ideogram configuration object\n */\nfunction _initRelatedGenes(config, annotsInList) {\n\n  const isHuman = slug(config.organism) === 'homo-sapiens';\n\n  if (config.relatedGenesMode === 'leads') {\n    delete config.onDrawAnnots;\n    delete config.relatedGenesMode;\n  };\n\n  const kitDefaults = Object.assign({\n    showParalogNeighborhoods: isHuman,\n    relatedGenesMode: 'related',\n    useCache: true,\n    awaitCache: true\n  }, globalKitDefaults);\n\n  return initSearchIdeogram(kitDefaults, config, annotsInList);\n}\n\n/**\n * Wrapper for Ideogram constructor, with generic \"Related genes\" options\n *\n * This function is made available as a static method on Ideogram.\n *\n * @param {Object} config Ideogram configuration object\n */\nfunction _initGeneHints(config, annotsInList) {\n  delete config.onPlotFoundGenes;\n\n  if (config.legendName) {\n    citedLegend[0].name = getLegendName(config.legendName);\n  }\n\n  config.legend = citedLegend;\n\n  const kitDefaults = Object.assign({\n    relatedGenesMode: 'hints',\n    chrMargin: -4,\n    annotationsPath: getDir('cache/homo-sapiens-top-genes.tsv'),\n    // annotationsPath: getDir('annotations/gene_leads.tsv'),\n    onDrawAnnots: plotGeneHints,\n    useCache: true\n  }, globalKitDefaults);\n\n  return initSearchIdeogram(kitDefaults, config, annotsInList);\n}\n\n/**\n * Wrapper for Ideogram constructor, with generic \"Related genes\" options\n *\n * This function is made available as a static method on Ideogram.\n *\n * @param {Object} config Ideogram configuration object\n */\n function _initGeneLeads(config, annotsInList) {\n  delete config.onPlotFoundGenes;\n\n  if (config.legendName) {\n    citedLegend[0].name = getLegendName(config.legendName);\n  }\n\n  config.legend = citedLegend;\n\n  const kitDefaults = Object.assign({\n    relatedGenesMode: 'leads',\n    chrMargin: -4,\n    // annotationsPath: getDir('cache/homo-sapiens-top-genes.tsv'),\n    annotationsPath: getDir('annotations/gene_leads.tsv'),\n    onDrawAnnots: plotGeneHints,\n    useCache: true\n  }, globalKitDefaults);\n\n  return initSearchIdeogram(kitDefaults, config, annotsInList);\n}\n\nfunction initSearchIdeogram(kitDefaults, config, annotsInList) {\n  if (annotsInList !== 'all') {\n    annotsInList = annotsInList.map(name => name.toLowerCase());\n  }\n  kitDefaults.annotsInList = annotsInList;\n\n  kitDefaults.legendPad = kitDefaults.showAnnotLabels ? 80 : 30;\n\n  if ('onWillShowAnnotTooltip' in config) {\n    const key = 'onWillShowAnnotTooltip';\n    const clientFn = config[key];\n    const defaultFunction = kitDefaults[key];\n    const newFunction = function(annot) {\n      annot = defaultFunction.bind(this)(annot);\n      annot = clientFn.bind(this)(annot);\n      return annot;\n    };\n    kitDefaults[key] = newFunction;\n    delete config[key];\n  }\n\n  if ('onDidShowAnnotTooltip' in config) {\n    const key = 'onDidShowAnnotTooltip';\n    const clientFn = config[key];\n    const defaultFunction = kitDefaults[key];\n    const newFunction = function(annot) {\n      annot = defaultFunction.bind(this)(annot);\n      annot = clientFn.bind(this)(annot);\n      return annot;\n    };\n    kitDefaults[key] = newFunction;\n    delete config[key];\n  }\n\n  if ('onDrawAnnots' in config) {\n    const key = 'onDrawAnnots';\n    const clientFn = config[key];\n    const defaultFn = kitDefaults[key];\n    const newFunction = function() {\n      if (defaultFn) defaultFn.bind(this)();\n      clientFn.bind(this)();\n    };\n    kitDefaults[key] = newFunction;\n    delete config[key];\n  }\n\n  // Override kit defaults if client specifies otherwise\n  const kitConfig = Object.assign(kitDefaults, config);\n\n  const ideogram = new Ideogram(kitConfig);\n\n  // Called upon 1) finding paralogs, and 2) finding interacting genes\n  if (config.onFindGenes) {\n    ideogram.onFindGenesCallback = config.onFindGenes;\n  }\n\n  // Called upon completing last plot, including all related genes\n  if (config.onPlotFoundGenes) {\n    ideogram.onPlotFoundGenesCallback = config.onPlotFoundGenes;\n  }\n\n  ideogram.getTooltipAnalytics = getRelatedGenesTooltipAnalytics;\n\n  ideogram.annotSortFunction = sortByRelatedType;\n\n  initAnalyzeRelatedGenes(ideogram);\n\n  return ideogram;\n}\n\nexport {\n  _initGeneHints, _initGeneLeads, _initRelatedGenes,\n  plotRelatedGenes, getRelatedGenesByType\n};\n","/**\n * @fileoverview Core module of Ideogram.js, links all other modules\n * This file defines the Ideogram class, its constructor method, and its\n * static methods.  All instance methods are defined in other modules.\n *\n */\n\nimport version from './version';\n\nimport {\n  configure, initDrawChromosomes, handleRotateOnClick, onLoad,\n  init, finishInit, writeContainer\n} from './init/init';\n\nimport {\n  onLoadAnnots, onDrawAnnots, processAnnotData, restoreDefaultTracks,\n  updateDisplayedTracks, initAnnotSettings, fetchAnnots, drawAnnots,\n  getHistogramBars, drawHeatmaps, deserializeAnnotsForHeatmap, fillAnnots,\n  drawProcessedAnnots, drawSynteny, startHideAnnotTooltipTimeout,\n  showAnnotTooltip, onWillShowAnnotTooltip, onDidShowAnnotTooltip,\n  setOriginalTrackIndexes,\n  afterRawAnnots, onClickAnnot, downloadAnnotations, addAnnotLabel,\n  removeAnnotLabel, fillAnnotLabels, clearAnnotLabels, flattenAnnots\n  // fadeOutAnnotLabels\n} from './annotations/annotations';\n\nimport {highlight, unhighlight} from './annotations/highlight';\n\nimport {\n  esearch, esummary, elink,\n  getOrganismFromEutils, getTaxids,\n  getAssemblyAndChromosomesFromEutils\n} from './services/services';\n\nimport {\n  drawBandLabels, getBandColorGradients, processBandData,\n  setBandsToShow, hideUnshownBandLabels, drawBandLabelText, drawBandLabelStalk\n} from './bands/bands';\n\nimport {onBrushMove, onBrushEnd, createBrush} from './brush';\nimport {onCursorMove, createClickCursor} from './cursor';\nimport {drawSexChromosomes, setSexChromosomes} from './sex-chromosomes';\nimport {convertBpToPx, convertPxToBp} from './coordinate-converters';\nimport {\n  unpackAnnots, packAnnots, initCrossFilter, filterAnnots\n} from './filter';\n\nimport {\n  assemblyIsAccession, getDataDir, round, onDidRotate, getSvg, d3,\n  getTaxid, getCommonName, getScientificName, fetch as _fetch,\n  isRoman, parseRoman\n} from './lib';\n\nimport {\n  getChromosomeModel, getChromosomePixels\n} from './views/chromosome-model';\n\nimport {\n  appendHomolog, drawChromosome, rotateAndToggleDisplay, setOverflowScroll\n} from './views/draw-chromosomes';\n\nimport {\n  drawChromosomeLabels, rotateChromosomeLabels\n} from './views/chromosome-labels.js';\n\nimport {\n  _initGeneHints, _initGeneLeads, _initRelatedGenes,\n  plotRelatedGenes, getRelatedGenesByType\n} from './kit/related-genes';\n\nexport default class Ideogram {\n  constructor(config) {\n\n    // Functions from init.js\n    this.configure = configure;\n    this.initDrawChromosomes = initDrawChromosomes;\n    this.onLoad = onLoad;\n    this.handleRotateOnClick = handleRotateOnClick;\n    this.init = init;\n    this.finishInit = finishInit;\n    this.writeContainer = writeContainer;\n\n    // Functions from annotations.js\n    this.onLoadAnnots = onLoadAnnots;\n    this.onDrawAnnots = onDrawAnnots;\n    this.processAnnotData = processAnnotData;\n    this.restoreDefaultTracks = restoreDefaultTracks;\n    this.updateDisplayedTracks = updateDisplayedTracks;\n    this.initAnnotSettings = initAnnotSettings;\n    this.fetchAnnots = fetchAnnots;\n    this.drawAnnots = drawAnnots;\n    this.getHistogramBars = getHistogramBars;\n    this.drawHeatmaps = drawHeatmaps;\n    this.deserializeAnnotsForHeatmap = deserializeAnnotsForHeatmap;\n    this.fillAnnots = fillAnnots;\n    this.drawProcessedAnnots = drawProcessedAnnots;\n    this.drawSynteny = drawSynteny;\n    this.startHideAnnotTooltipTimeout = startHideAnnotTooltipTimeout;\n    this.showAnnotTooltip = showAnnotTooltip;\n    this.onWillShowAnnotTooltip = onWillShowAnnotTooltip;\n    this.onDidShowAnnotTooltip = onDidShowAnnotTooltip;\n    this.onClickAnnot = onClickAnnot;\n    this.setOriginalTrackIndexes = setOriginalTrackIndexes;\n    this.afterRawAnnots = afterRawAnnots;\n    this.downloadAnnotations = downloadAnnotations;\n    this.addAnnotLabel = addAnnotLabel;\n    this.removeAnnotLabel = removeAnnotLabel;\n    // this.fadeOutAnnotLabels = fadeOutAnnotLabels;\n    this.fillAnnotLabels = fillAnnotLabels;\n    this.clearAnnotLabels = clearAnnotLabels;\n    this.flattenAnnots = flattenAnnots;\n\n    this.highlight = highlight;\n    this.unhighlight = unhighlight;\n\n    // Variables and functions from services.js\n    this.esearch = esearch;\n    this.esummary = esummary;\n    this.elink = elink;\n    this.getOrganismFromEutils = getOrganismFromEutils;\n    this.getTaxids = getTaxids;\n    this.getAssemblyAndChromosomesFromEutils =\n      getAssemblyAndChromosomesFromEutils;\n\n    // Functions from bands.js\n    this.drawBandLabels = drawBandLabels;\n    this.getBandColorGradients = getBandColorGradients;\n    this.processBandData = processBandData;\n    this.setBandsToShow = setBandsToShow;\n    this.hideUnshownBandLabels = hideUnshownBandLabels;\n    this.drawBandLabelText = drawBandLabelText;\n    this.drawBandLabelStalk = drawBandLabelStalk;\n\n    // Functions from brush.js\n    this.onBrushMove = onBrushMove;\n    this.onBrushEnd = onBrushEnd;\n    this.createBrush = createBrush;\n\n    // Functions from cursor.js\n    this.createClickCursor = createClickCursor;\n    this.onCursorMove = onCursorMove;\n\n    // Functions from sex-chromosomes.js\n    this.drawSexChromosomes = drawSexChromosomes;\n    this.setSexChromosomes = setSexChromosomes;\n\n    // Functions from coordinate-converters.js\n    this.convertBpToPx = convertBpToPx;\n    this.convertPxToBp = convertPxToBp;\n\n    // Functions from filter.js\n    this.unpackAnnots = unpackAnnots;\n    this.packAnnots = packAnnots;\n    this.initCrossFilter = initCrossFilter;\n    this.filterAnnots = filterAnnots;\n\n    // Functions from lib\n    this.assemblyIsAccession = assemblyIsAccession;\n    this.getDataDir = getDataDir;\n    this.round = round;\n    this.onDidRotate = onDidRotate;\n    this.getSvg = getSvg;\n    this.fetch = _fetch;\n    this.getTaxid = getTaxid;\n    this.getCommonName = getCommonName;\n    this.getScientificName = getScientificName;\n\n    // Functions from views/chromosome-model.js\n    this.getChromosomeModel = getChromosomeModel;\n    this.getChromosomePixels = getChromosomePixels;\n\n    // Functions from views/chromosome-labels.js\n    this.drawChromosomeLabels = drawChromosomeLabels;\n    this.rotateChromosomeLabels = rotateChromosomeLabels;\n\n    // Functions from views/draw-chromosomes.js\n    this.appendHomolog = appendHomolog;\n    this.drawChromosome = drawChromosome;\n    this.rotateAndToggleDisplay = rotateAndToggleDisplay;\n    this.setOverflowScroll = setOverflowScroll;\n\n    this.plotRelatedGenes = plotRelatedGenes;\n    this.getRelatedGenesByType = getRelatedGenesByType;\n\n    this.configure(config);\n  }\n\n  /**\n   * Get the current version of Ideogram.js\n   */\n  static get version() {\n    return version;\n  }\n\n  /**\n  * Enable use of D3 in client apps, via \"d3 = Ideogram.d3\"\n  */\n  static get d3() {\n    return d3;\n  }\n\n  /**\n   * Request data from Ensembl REST API\n   * Docs: https://rest.ensembl.org/\n   *\n   * @param {String} path URL path\n   * @param {Object} body POST body\n   * @param {String} method HTTP method; 'GET' (default) or 'POST'\n   */\n  static async fetchEnsembl(path, body = null, method = 'GET') {\n    const init = {\n      method: method\n    };\n    if (body !== null) init.body = JSON.stringify(body);\n    if (method === 'GET') {\n      // Use HTTP parameter, not header, to avoid needless OPTIONS request\n      const delimiter = path.includes('&') ? '&' : '?';\n      path += delimiter + 'content-type=application/json';\n    } else {\n      // Method is POST, so content-type must be defined in header\n      init.headers = {'Content-Type': 'application/json'};\n    }\n\n    // const random = Math.random();\n    // console.log(random)\n    // if (random < 0.5) {\n    const response = await fetch(`https://rest.ensembl.org${path}`, init);\n    const json = await response.json();\n    return json;\n    // } else {\n    //   // Mock error\n    //   init.headers = {'Content-Type': 'application/json'};\n    //   const response = await fetch('https://httpstat.us/500/cors', init);\n    //   const json = await response.json();\n    //   return json;\n    // }\n  }\n\n  /**\n   * Helper for sortChromosomes().\n   * Gets names and biological types for diverse chromosome variables\n   */\n  static getChrSortNamesAndTypes(a, b) {\n    var chrAName, chrBName,\n      aIsCP, bIsCP, aIsMT, bIsMT, aIsAP, bIsAP, aIsNuclear, bIsNuclear;\n\n    if (typeof a === 'string' || 'chr' in a && 'annots' in a) {\n      // Chromosome data is from either:\n      //    - Ideogram static file cache (e.g. homo-sapiens.json)\n      //    - Ideogram raw annotations\n      chrAName = (typeof a === 'string') ? a : a.chr;\n      chrBName = (typeof b === 'string') ? b : b.chr;\n\n      aIsCP = chrAName === 'CP';\n      bIsCP = chrBName === 'CP';\n      aIsMT = chrAName === 'MT';\n      bIsMT = chrBName === 'MT';\n      aIsAP = chrAName === 'AP';\n      bIsAP = chrBName === 'AP';\n      aIsNuclear = (!aIsCP && !aIsMT && !aIsAP);\n      bIsNuclear = (!bIsCP && !bIsMT && !bIsAP);\n    } else {\n      // Chromosome data is from NCBI E-Utils web API\n      chrAName = a.name;\n      chrBName = b.name;\n\n      aIsCP = a.type === 'chloroplast';\n      bIsCP = b.type === 'chloroplast';\n      aIsMT = a.type === 'mitochondrion';\n      bIsMT = b.type === 'mitochondrion';\n      aIsAP = a.type === 'apicoplast';\n      bIsAP = b.type === 'apicoplast';\n      aIsNuclear = a.type === 'nuclear';\n      bIsNuclear = b.type === 'nuclear';\n    }\n\n    const chrTypes = {\n      aIsNuclear, bIsNuclear, aIsCP, bIsCP, aIsMT, bIsMT, aIsAP, bIsAP\n    };\n\n    return [chrAName, chrBName, chrTypes];\n  }\n\n  /**\n   * Sorts two chromosome objects by type and name\n   * - Nuclear chromosomes come before non-nuclear chromosomes.\n   * - Among nuclear chromosomes, use \"natural sorting\", e.g.\n   *   numbers come before letters\n   * - Among non-nuclear chromosomes, i.e. \"MT\" (mitochondrial DNA) and\n   *   \"CP\" (chromoplast DNA), MT comes first\n   *\n   * @param a Chromosome string or object \"A\"\n   * @param b Chromosome string or object \"B\"\n   * @returns {Number} JavaScript sort order indicator\n   */\n  static sortChromosomes(a, b) {\n\n    let [chrAName, chrBName, chrTypes] =\n      Ideogram.getChrSortNamesAndTypes(a, b);\n\n    const {\n      aIsNuclear, bIsNuclear, aIsCP, bIsCP, aIsMT, bIsMT, aIsAP, bIsAP\n    } = chrTypes;\n\n    if (aIsNuclear && bIsNuclear) {\n\n      if (isRoman(chrAName) && isRoman(chrBName)) {\n        // As in yeast genome\n        chrAName = parseRoman(chrAName).toString();\n        chrBName = parseRoman(chrBName).toString();\n      }\n\n      return chrAName.localeCompare(chrBName, 'en', {numeric: true});\n    } else if (!aIsNuclear && bIsNuclear) {\n      return 1;\n    } else if (aIsMT && bIsCP) {\n      return 1;\n    } else if (aIsCP && bIsMT) {\n      return -1;\n    } else if (!aIsAP && !aIsMT && !aIsCP && (bIsMT || bIsCP || bIsAP)) {\n      return -1;\n    }\n  }\n\n  /**\n   * Wrapper for Ideogram constructor, with generic \"Related genes\" options\n   *\n   * @param {Object} config Ideogram configuration object\n   */\n  static initRelatedGenes(config, annotsInList='all') {\n    return _initRelatedGenes(config, annotsInList);\n  }\n\n  /**\n   * Wrapper for Ideogram constructor, with generic \"Related genes\" options\n   *\n   * @param {Object} config Ideogram configuration 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\ No newline at end of file
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Selection(this._enter || this._groups.map(sparse), this._parents);\n}\n\nexport function EnterNode(parent, datum) {\n  this.ownerDocument = parent.ownerDocument;\n  this.namespaceURI = parent.namespaceURI;\n  this._next = null;\n  this._parent = parent;\n  this.__data__ = datum;\n}\n\nEnterNode.prototype = {\n  constructor: EnterNode,\n  appendChild: function(child) { return this._parent.insertBefore(child, this._next); },\n  insertBefore: function(child, next) { return this._parent.insertBefore(child, next); },\n  querySelector: function(selector) { return this._parent.querySelector(selector); },\n  querySelectorAll: function(selector) { return this._parent.querySelectorAll(selector); }\n};\n","export default function(x) {\n  return function() {\n    return x;\n  };\n}\n","import {Selection} from \"./index.js\";\nimport {EnterNode} from \"./enter.js\";\nimport array from \"../array.js\";\nimport constant from \"../constant.js\";\n\nfunction bindIndex(parent, group, enter, update, exit, data) {\n  var i = 0,\n      node,\n      groupLength = group.length,\n      dataLength = data.length;\n\n  // Put any non-null nodes that fit into update.\n  // Put any null nodes into enter.\n  // Put any remaining data into enter.\n  for (; i < dataLength; ++i) {\n    if (node = group[i]) {\n      node.__data__ = data[i];\n      update[i] = node;\n    } else {\n      enter[i] = new EnterNode(parent, data[i]);\n    }\n  }\n\n  // Put any non-null nodes that don’t fit into exit.\n  for (; i < groupLength; ++i) {\n    if (node = group[i]) {\n      exit[i] = node;\n    }\n  }\n}\n\nfunction bindKey(parent, group, enter, update, exit, data, key) {\n  var i,\n      node,\n      nodeByKeyValue = new Map,\n      groupLength = group.length,\n      dataLength = data.length,\n      keyValues = new Array(groupLength),\n      keyValue;\n\n  // Compute the key for each node.\n  // If multiple nodes have the same key, the duplicates are added to exit.\n  for (i = 0; i < groupLength; ++i) {\n    if (node = group[i]) {\n      keyValues[i] = keyValue = key.call(node, node.__data__, i, group) + \"\";\n      if (nodeByKeyValue.has(keyValue)) {\n        exit[i] = node;\n      } else {\n        nodeByKeyValue.set(keyValue, node);\n      }\n    }\n  }\n\n  // Compute the key for each datum.\n  // If there a node associated with this key, join and add it to update.\n  // If there is not (or the key is a duplicate), add it to enter.\n  for (i = 0; i < dataLength; ++i) {\n    keyValue = key.call(parent, data[i], i, data) + \"\";\n    if (node = nodeByKeyValue.get(keyValue)) {\n      update[i] = node;\n      node.__data__ = data[i];\n      nodeByKeyValue.delete(keyValue);\n    } else {\n      enter[i] = new EnterNode(parent, data[i]);\n    }\n  }\n\n  // Add any remaining nodes that were not bound to data to exit.\n  for (i = 0; i < groupLength; ++i) {\n    if ((node = group[i]) && (nodeByKeyValue.get(keyValues[i]) === node)) {\n      exit[i] = node;\n    }\n  }\n}\n\nfunction datum(node) {\n  return node.__data__;\n}\n\nexport default function(value, key) {\n  if (!arguments.length) return Array.from(this, datum);\n\n  var bind = key ? bindKey : bindIndex,\n      parents = this._parents,\n      groups = this._groups;\n\n  if (typeof value !== \"function\") value = constant(value);\n\n  for (var m = groups.length, update = new Array(m), enter = new Array(m), exit = new Array(m), j = 0; j < m; ++j) {\n    var parent = parents[j],\n        group = groups[j],\n        groupLength = group.length,\n        data = array(value.call(parent, parent && parent.__data__, j, parents)),\n        dataLength = data.length,\n        enterGroup = enter[j] = new Array(dataLength),\n        updateGroup = update[j] = new Array(dataLength),\n        exitGroup = exit[j] = new Array(groupLength);\n\n    bind(parent, group, enterGroup, updateGroup, exitGroup, data, key);\n\n    // Now connect the enter nodes to their following update node, such that\n    // appendChild can insert the materialized enter node before this node,\n    // rather than at the end of the parent node.\n    for (var i0 = 0, i1 = 0, previous, next; i0 < dataLength; ++i0) {\n      if (previous = enterGroup[i0]) {\n        if (i0 >= i1) i1 = i0 + 1;\n        while (!(next = updateGroup[i1]) && ++i1 < dataLength);\n        previous._next = next || null;\n      }\n    }\n  }\n\n  update = new Selection(update, parents);\n  update._enter = enter;\n  update._exit = exit;\n  return update;\n}\n","import {Selection} from \"./index.js\";\n\nexport default function(compare) {\n  if (!compare) compare = ascending;\n\n  function compareNode(a, b) {\n    return a && b ? compare(a.__data__, b.__data__) : !a - !b;\n  }\n\n  for (var groups = this._groups, m = groups.length, sortgroups = new Array(m), j = 0; j < m; ++j) {\n    for (var group = groups[j], n = group.length, sortgroup = sortgroups[j] = new Array(n), node, i = 0; i < n; ++i) {\n      if (node = group[i]) {\n        sortgroup[i] = node;\n      }\n    }\n    sortgroup.sort(compareNode);\n  }\n\n  return new Selection(sortgroups, this._parents).order();\n}\n\nfunction ascending(a, b) {\n  return a < b ? -1 : a > b ? 1 : a >= b ? 0 : NaN;\n}\n","export var xhtml = \"http://www.w3.org/1999/xhtml\";\n\nexport default {\n  svg: \"http://www.w3.org/2000/svg\",\n  xhtml: xhtml,\n  xlink: \"http://www.w3.org/1999/xlink\",\n  xml: \"http://www.w3.org/XML/1998/namespace\",\n  xmlns: \"http://www.w3.org/2000/xmlns/\"\n};\n","import namespaces from \"./namespaces.js\";\n\nexport default function(name) {\n  var prefix = name += \"\", i = prefix.indexOf(\":\");\n  if (i >= 0 && (prefix = name.slice(0, i)) !== \"xmlns\") name = name.slice(i + 1);\n  return namespaces.hasOwnProperty(prefix) ? {space: namespaces[prefix], local: name} : name; // eslint-disable-line no-prototype-builtins\n}\n","import namespace from \"../namespace.js\";\n\nfunction attrRemove(name) {\n  return function() {\n    this.removeAttribute(name);\n  };\n}\n\nfunction attrRemoveNS(fullname) {\n  return function() {\n    this.removeAttributeNS(fullname.space, fullname.local);\n  };\n}\n\nfunction attrConstant(name, value) {\n  return function() {\n    this.setAttribute(name, value);\n  };\n}\n\nfunction attrConstantNS(fullname, value) {\n  return function() {\n    this.setAttributeNS(fullname.space, fullname.local, value);\n  };\n}\n\nfunction attrFunction(name, value) {\n  return function() {\n    var v = value.apply(this, arguments);\n    if (v == null) this.removeAttribute(name);\n    else this.setAttribute(name, v);\n  };\n}\n\nfunction attrFunctionNS(fullname, value) {\n  return function() {\n    var v = value.apply(this, arguments);\n    if (v == null) this.removeAttributeNS(fullname.space, fullname.local);\n    else this.setAttributeNS(fullname.space, fullname.local, v);\n  };\n}\n\nexport default function(name, value) {\n  var fullname = namespace(name);\n\n  if (arguments.length < 2) {\n    var node = this.node();\n    return fullname.local\n        ? node.getAttributeNS(fullname.space, fullname.local)\n        : node.getAttribute(fullname);\n  }\n\n  return this.each((value == null\n      ? (fullname.local ? attrRemoveNS : attrRemove) : (typeof value === \"function\"\n      ? (fullname.local ? attrFunctionNS : attrFunction)\n      : (fullname.local ? attrConstantNS : attrConstant)))(fullname, value));\n}\n","export default function(node) {\n  return (node.ownerDocument && node.ownerDocument.defaultView) // node is a Node\n      || (node.document && node) // node is a Window\n      || node.defaultView; // node is a Document\n}\n","import defaultView from \"../window.js\";\n\nfunction styleRemove(name) {\n  return function() {\n    this.style.removeProperty(name);\n  };\n}\n\nfunction styleConstant(name, value, priority) {\n  return function() {\n    this.style.setProperty(name, value, priority);\n  };\n}\n\nfunction styleFunction(name, value, priority) {\n  return function() {\n    var v = value.apply(this, arguments);\n    if (v == null) this.style.removeProperty(name);\n    else this.style.setProperty(name, v, priority);\n  };\n}\n\nexport default function(name, value, priority) {\n  return arguments.length > 1\n      ? this.each((value == null\n            ? styleRemove : typeof value === \"function\"\n            ? styleFunction\n            : styleConstant)(name, value, priority == null ? \"\" : priority))\n      : styleValue(this.node(), name);\n}\n\nexport function styleValue(node, name) {\n  return node.style.getPropertyValue(name)\n      || defaultView(node).getComputedStyle(node, null).getPropertyValue(name);\n}\n","function propertyRemove(name) {\n  return function() {\n    delete this[name];\n  };\n}\n\nfunction propertyConstant(name, value) {\n  return function() {\n    this[name] = value;\n  };\n}\n\nfunction propertyFunction(name, value) {\n  return function() {\n    var v = value.apply(this, arguments);\n    if (v == null) delete this[name];\n    else this[name] = v;\n  };\n}\n\nexport default function(name, value) {\n  return arguments.length > 1\n      ? this.each((value == null\n          ? propertyRemove : typeof value === \"function\"\n          ? propertyFunction\n          : propertyConstant)(name, value))\n      : this.node()[name];\n}\n","function classArray(string) {\n  return string.trim().split(/^|\\s+/);\n}\n\nfunction classList(node) {\n  return node.classList || new ClassList(node);\n}\n\nfunction ClassList(node) {\n  this._node = node;\n  this._names = classArray(node.getAttribute(\"class\") || \"\");\n}\n\nClassList.prototype = {\n  add: function(name) {\n    var i = this._names.indexOf(name);\n    if (i < 0) {\n      this._names.push(name);\n      this._node.setAttribute(\"class\", this._names.join(\" \"));\n    }\n  },\n  remove: function(name) {\n    var i = this._names.indexOf(name);\n    if (i >= 0) {\n      this._names.splice(i, 1);\n      this._node.setAttribute(\"class\", this._names.join(\" \"));\n    }\n  },\n  contains: function(name) {\n    return this._names.indexOf(name) >= 0;\n  }\n};\n\nfunction classedAdd(node, names) {\n  var list = classList(node), i = -1, n = names.length;\n  while (++i < n) list.add(names[i]);\n}\n\nfunction classedRemove(node, names) {\n  var list = classList(node), i = -1, n = names.length;\n  while (++i < n) list.remove(names[i]);\n}\n\nfunction classedTrue(names) {\n  return function() {\n    classedAdd(this, names);\n  };\n}\n\nfunction classedFalse(names) {\n  return function() {\n    classedRemove(this, names);\n  };\n}\n\nfunction classedFunction(names, value) {\n  return function() {\n    (value.apply(this, arguments) ? classedAdd : classedRemove)(this, names);\n  };\n}\n\nexport default function(name, value) {\n  var names = classArray(name + \"\");\n\n  if (arguments.length < 2) {\n    var list = classList(this.node()), i = -1, n = names.length;\n    while (++i < n) if (!list.contains(names[i])) return false;\n    return true;\n  }\n\n  return this.each((typeof value === \"function\"\n      ? classedFunction : value\n      ? classedTrue\n      : classedFalse)(names, value));\n}\n","function textRemove() {\n  this.textContent = \"\";\n}\n\nfunction textConstant(value) {\n  return function() {\n    this.textContent = value;\n  };\n}\n\nfunction textFunction(value) {\n  return function() {\n    var v = value.apply(this, arguments);\n    this.textContent = v == null ? \"\" : v;\n  };\n}\n\nexport default function(value) {\n  return arguments.length\n      ? this.each(value == null\n          ? textRemove : (typeof value === \"function\"\n          ? textFunction\n          : textConstant)(value))\n      : this.node().textContent;\n}\n","function htmlRemove() {\n  this.innerHTML = \"\";\n}\n\nfunction htmlConstant(value) {\n  return function() {\n    this.innerHTML = value;\n  };\n}\n\nfunction htmlFunction(value) {\n  return function() {\n    var v = value.apply(this, arguments);\n    this.innerHTML = v == null ? \"\" : v;\n  };\n}\n\nexport default function(value) {\n  return arguments.length\n      ? this.each(value == null\n          ? htmlRemove : (typeof value === \"function\"\n          ? htmlFunction\n          : htmlConstant)(value))\n      : this.node().innerHTML;\n}\n","function raise() {\n  if (this.nextSibling) this.parentNode.appendChild(this);\n}\n\nexport default function() {\n  return this.each(raise);\n}\n","function lower() {\n  if (this.previousSibling) this.parentNode.insertBefore(this, this.parentNode.firstChild);\n}\n\nexport default function() {\n  return this.each(lower);\n}\n","import namespace from \"./namespace.js\";\nimport {xhtml} from \"./namespaces.js\";\n\nfunction creatorInherit(name) {\n  return function() {\n    var document = this.ownerDocument,\n        uri = this.namespaceURI;\n    return uri === xhtml && document.documentElement.namespaceURI === xhtml\n        ? document.createElement(name)\n        : document.createElementNS(uri, name);\n  };\n}\n\nfunction creatorFixed(fullname) {\n  return function() {\n    return this.ownerDocument.createElementNS(fullname.space, fullname.local);\n  };\n}\n\nexport default function(name) {\n  var fullname = namespace(name);\n  return (fullname.local\n      ? creatorFixed\n      : creatorInherit)(fullname);\n}\n","import creator from \"../creator.js\";\nimport selector from \"../selector.js\";\n\nfunction constantNull() {\n  return null;\n}\n\nexport default function(name, before) {\n  var create = typeof name === \"function\" ? name : creator(name),\n      select = before == null ? constantNull : typeof before === \"function\" ? before : selector(before);\n  return this.select(function() {\n    return this.insertBefore(create.apply(this, arguments), select.apply(this, arguments) || null);\n  });\n}\n","function remove() {\n  var parent = this.parentNode;\n  if (parent) parent.removeChild(this);\n}\n\nexport default function() {\n  return this.each(remove);\n}\n","function selection_cloneShallow() {\n  var clone = this.cloneNode(false), parent = this.parentNode;\n  return parent ? parent.insertBefore(clone, this.nextSibling) : clone;\n}\n\nfunction selection_cloneDeep() {\n  var clone = this.cloneNode(true), parent = this.parentNode;\n  return parent ? parent.insertBefore(clone, this.nextSibling) : clone;\n}\n\nexport default function(deep) {\n  return this.select(deep ? selection_cloneDeep : selection_cloneShallow);\n}\n","function contextListener(listener) {\n  return function(event) {\n    listener.call(this, event, this.__data__);\n  };\n}\n\nfunction parseTypenames(typenames) {\n  return typenames.trim().split(/^|\\s+/).map(function(t) {\n    var name = \"\", i = t.indexOf(\".\");\n    if (i >= 0) name = t.slice(i + 1), t = t.slice(0, i);\n    return {type: t, name: name};\n  });\n}\n\nfunction onRemove(typename) {\n  return function() {\n    var on = this.__on;\n    if (!on) return;\n    for (var j = 0, i = -1, m = on.length, o; j < m; ++j) {\n      if (o = on[j], (!typename.type || o.type === typename.type) && o.name === typename.name) {\n        this.removeEventListener(o.type, o.listener, o.options);\n      } else {\n        on[++i] = o;\n      }\n    }\n    if (++i) on.length = i;\n    else delete this.__on;\n  };\n}\n\nfunction onAdd(typename, value, options) {\n  return function() {\n    var on = this.__on, o, listener = contextListener(value);\n    if (on) for (var j = 0, m = on.length; j < m; ++j) {\n      if ((o = on[j]).type === typename.type && o.name === typename.name) {\n        this.removeEventListener(o.type, o.listener, o.options);\n        this.addEventListener(o.type, o.listener = listener, o.options = options);\n        o.value = value;\n        return;\n      }\n    }\n    this.addEventListener(typename.type, listener, options);\n    o = {type: typename.type, name: typename.name, value: value, listener: listener, options: options};\n    if (!on) this.__on = [o];\n    else on.push(o);\n  };\n}\n\nexport default function(typename, value, options) {\n  var typenames = parseTypenames(typename + \"\"), i, n = typenames.length, t;\n\n  if (arguments.length < 2) {\n    var on = this.node().__on;\n    if (on) for (var j = 0, m = on.length, o; j < m; ++j) {\n      for (i = 0, o = on[j]; i < n; ++i) {\n        if ((t = typenames[i]).type === o.type && t.name === o.name) {\n          return o.value;\n        }\n      }\n    }\n    return;\n  }\n\n  on = value ? onAdd : onRemove;\n  for (i = 0; i < n; ++i) this.each(on(typenames[i], value, options));\n  return this;\n}\n","import defaultView from \"../window.js\";\n\nfunction dispatchEvent(node, type, params) {\n  var window = defaultView(node),\n      event = window.CustomEvent;\n\n  if (typeof event === \"function\") {\n    event = new event(type, params);\n  } else {\n    event = window.document.createEvent(\"Event\");\n    if (params) event.initEvent(type, params.bubbles, params.cancelable), event.detail = params.detail;\n    else event.initEvent(type, false, false);\n  }\n\n  node.dispatchEvent(event);\n}\n\nfunction dispatchConstant(type, params) {\n  return function() {\n    return dispatchEvent(this, type, params);\n  };\n}\n\nfunction dispatchFunction(type, params) {\n  return function() {\n    return dispatchEvent(this, type, params.apply(this, arguments));\n  };\n}\n\nexport default function(type, params) {\n  return this.each((typeof params === \"function\"\n      ? dispatchFunction\n      : dispatchConstant)(type, params));\n}\n","import selection_select from \"./select.js\";\nimport selection_selectAll from \"./selectAll.js\";\nimport selection_selectChild from \"./selectChild.js\";\nimport selection_selectChildren from \"./selectChildren.js\";\nimport selection_filter from \"./filter.js\";\nimport selection_data from \"./data.js\";\nimport selection_enter from \"./enter.js\";\nimport selection_exit from \"./exit.js\";\nimport selection_join from \"./join.js\";\nimport selection_merge from \"./merge.js\";\nimport selection_order from \"./order.js\";\nimport selection_sort from \"./sort.js\";\nimport selection_call from \"./call.js\";\nimport selection_nodes from \"./nodes.js\";\nimport selection_node from \"./node.js\";\nimport selection_size from \"./size.js\";\nimport selection_empty from \"./empty.js\";\nimport selection_each from \"./each.js\";\nimport selection_attr from \"./attr.js\";\nimport selection_style from \"./style.js\";\nimport selection_property from \"./property.js\";\nimport selection_classed from \"./classed.js\";\nimport selection_text from \"./text.js\";\nimport selection_html from \"./html.js\";\nimport selection_raise from \"./raise.js\";\nimport selection_lower from \"./lower.js\";\nimport selection_append from \"./append.js\";\nimport selection_insert from \"./insert.js\";\nimport selection_remove from \"./remove.js\";\nimport selection_clone from \"./clone.js\";\nimport selection_datum from \"./datum.js\";\nimport selection_on from \"./on.js\";\nimport selection_dispatch from \"./dispatch.js\";\nimport selection_iterator from \"./iterator.js\";\n\nexport var root = [null];\n\nexport function Selection(groups, parents) {\n  this._groups = groups;\n  this._parents = parents;\n}\n\nfunction selection() {\n  return new Selection([[document.documentElement]], root);\n}\n\nfunction selection_selection() {\n  return this;\n}\n\nSelection.prototype = selection.prototype = {\n  constructor: Selection,\n  select: selection_select,\n  selectAll: selection_selectAll,\n  selectChild: selection_selectChild,\n  selectChildren: selection_selectChildren,\n  filter: selection_filter,\n  data: selection_data,\n  enter: selection_enter,\n  exit: selection_exit,\n  join: selection_join,\n  merge: selection_merge,\n  selection: selection_selection,\n  order: selection_order,\n  sort: selection_sort,\n  call: selection_call,\n  nodes: selection_nodes,\n  node: selection_node,\n  size: selection_size,\n  empty: selection_empty,\n  each: selection_each,\n  attr: selection_attr,\n  style: selection_style,\n  property: selection_property,\n  classed: selection_classed,\n  text: selection_text,\n  html: selection_html,\n  raise: selection_raise,\n  lower: selection_lower,\n  append: selection_append,\n  insert: selection_insert,\n  remove: selection_remove,\n  clone: selection_clone,\n  datum: selection_datum,\n  on: selection_on,\n  dispatch: selection_dispatch,\n  [Symbol.iterator]: selection_iterator\n};\n\nexport default selection;\n","import {Selection} from \"./index.js\";\nimport selector from \"../selector.js\";\n\nexport default function(select) {\n  if (typeof select !== \"function\") select = selector(select);\n\n  for (var groups = this._groups, m = groups.length, subgroups = new Array(m), j = 0; j < m; ++j) {\n    for (var group = groups[j], n = group.length, subgroup = subgroups[j] = new Array(n), node, subnode, i = 0; i < n; ++i) {\n      if ((node = group[i]) && (subnode = select.call(node, node.__data__, i, group))) {\n        if (\"__data__\" in node) subnode.__data__ = node.__data__;\n        subgroup[i] = subnode;\n      }\n    }\n  }\n\n  return new Selection(subgroups, this._parents);\n}\n","import {Selection} from \"./index.js\";\nimport array from \"../array.js\";\nimport selectorAll from \"../selectorAll.js\";\n\nfunction arrayAll(select) {\n  return function() {\n    var group = select.apply(this, arguments);\n    return group == null ? [] : array(group);\n  };\n}\n\nexport default function(select) {\n  if (typeof select === \"function\") select = arrayAll(select);\n  else select = selectorAll(select);\n\n  for (var groups = this._groups, m = groups.length, subgroups = [], parents = [], j = 0; j < m; ++j) {\n    for (var group = groups[j], n = group.length, node, i = 0; i < n; ++i) {\n      if (node = group[i]) {\n        subgroups.push(select.call(node, node.__data__, i, group));\n        parents.push(node);\n      }\n    }\n  }\n\n  return new Selection(subgroups, parents);\n}\n","import {Selection} from \"./index.js\";\nimport matcher from \"../matcher.js\";\n\nexport default function(match) {\n  if (typeof match !== \"function\") match = matcher(match);\n\n  for (var groups = this._groups, m = groups.length, subgroups = new Array(m), j = 0; j < m; ++j) {\n    for (var group = groups[j], n = group.length, subgroup = subgroups[j] = [], node, i = 0; i < n; ++i) {\n      if ((node = group[i]) && match.call(node, node.__data__, i, group)) {\n        subgroup.push(node);\n      }\n    }\n  }\n\n  return new Selection(subgroups, this._parents);\n}\n","import sparse from \"./sparse.js\";\nimport {Selection} from \"./index.js\";\n\nexport default function() {\n  return new Selection(this._exit || this._groups.map(sparse), this._parents);\n}\n","export default function(onenter, onupdate, onexit) {\n  var enter = this.enter(), update = this, exit = this.exit();\n  enter = typeof onenter === \"function\" ? onenter(enter) : enter.append(onenter + \"\");\n  if (onupdate != null) update = onupdate(update);\n  if (onexit == null) exit.remove(); else onexit(exit);\n  return enter && update ? enter.merge(update).order() : update;\n}\n","import {Selection} from \"./index.js\";\n\nexport default function(selection) {\n  if (!(selection instanceof Selection)) throw new Error(\"invalid merge\");\n\n  for (var groups0 = this._groups, groups1 = selection._groups, m0 = groups0.length, m1 = groups1.length, m = Math.min(m0, m1), merges = new Array(m0), j = 0; j < m; ++j) {\n    for (var group0 = groups0[j], group1 = groups1[j], n = group0.length, merge = merges[j] = new Array(n), node, i = 0; i < n; ++i) {\n      if (node = group0[i] || group1[i]) {\n        merge[i] = node;\n      }\n    }\n  }\n\n  for (; j < m0; ++j) {\n    merges[j] = groups0[j];\n  }\n\n  return new Selection(merges, this._parents);\n}\n","export default function() {\n\n  for (var groups = this._groups, j = -1, m = groups.length; ++j < m;) {\n    for (var group = groups[j], i = group.length - 1, next = group[i], node; --i >= 0;) {\n      if (node = group[i]) {\n        if (next && node.compareDocumentPosition(next) ^ 4) next.parentNode.insertBefore(node, next);\n        next = node;\n      }\n    }\n  }\n\n  return this;\n}\n","export default function() {\n  var callback = arguments[0];\n  arguments[0] = this;\n  callback.apply(null, arguments);\n  return this;\n}\n","export default function() {\n  return Array.from(this);\n}\n","export default function() {\n\n  for (var groups = this._groups, j = 0, m = groups.length; j < m; ++j) {\n    for (var group = groups[j], i = 0, n = group.length; i < n; ++i) {\n      var node = group[i];\n      if (node) return node;\n    }\n  }\n\n  return null;\n}\n","export default function() {\n  let size = 0;\n  for (const node of this) ++size; // eslint-disable-line no-unused-vars\n  return size;\n}\n","export default function() {\n  return !this.node();\n}\n","export default function(callback) {\n\n  for (var groups = this._groups, j = 0, m = groups.length; j < m; ++j) {\n    for (var group = groups[j], i = 0, n = group.length, node; i < n; ++i) {\n      if (node = group[i]) callback.call(node, node.__data__, i, group);\n    }\n  }\n\n  return this;\n}\n","import creator from \"../creator.js\";\n\nexport default function(name) {\n  var create = typeof name === \"function\" ? name : creator(name);\n  return this.select(function() {\n    return this.appendChild(create.apply(this, arguments));\n  });\n}\n","export default function(value) {\n  return arguments.length\n      ? this.property(\"__data__\", value)\n      : this.node().__data__;\n}\n","export default function*() {\n  for (var groups = this._groups, j = 0, m = groups.length; j < m; ++j) {\n    for (var group = groups[j], i = 0, n = group.length, node; i < n; ++i) {\n      if (node = group[i]) yield node;\n    }\n  }\n}\n","import {Selection, root} from \"./selection/index.js\";\n\nexport default function(selector) {\n  return typeof selector === \"string\"\n      ? new Selection([[document.querySelector(selector)]], [document.documentElement])\n      : new Selection([[selector]], root);\n}\n","function responseBlob(response) {\n  if (!response.ok) throw new Error(response.status + \" \" + response.statusText);\n  return response.blob();\n}\n\nexport default function(input, init) {\n  return fetch(input, init).then(responseBlob);\n}\n","function responseArrayBuffer(response) {\n  if (!response.ok) throw new Error(response.status + \" \" + response.statusText);\n  return response.arrayBuffer();\n}\n\nexport default function(input, init) {\n  return fetch(input, init).then(responseArrayBuffer);\n}\n","var EOL = {},\n    EOF = {},\n    QUOTE = 34,\n    NEWLINE = 10,\n    RETURN = 13;\n\nfunction objectConverter(columns) {\n  return new Function(\"d\", \"return {\" + columns.map(function(name, i) {\n    return JSON.stringify(name) + \": d[\" + i + \"] || \\\"\\\"\";\n  }).join(\",\") + \"}\");\n}\n\nfunction customConverter(columns, f) {\n  var object = objectConverter(columns);\n  return function(row, i) {\n    return f(object(row), i, columns);\n  };\n}\n\n// Compute unique columns in order of discovery.\nfunction inferColumns(rows) {\n  var columnSet = Object.create(null),\n      columns = [];\n\n  rows.forEach(function(row) {\n    for (var column in row) {\n      if (!(column in columnSet)) {\n        columns.push(columnSet[column] = column);\n      }\n    }\n  });\n\n  return columns;\n}\n\nfunction pad(value, width) {\n  var s = value + \"\", length = s.length;\n  return length < width ? new Array(width - length + 1).join(0) + s : s;\n}\n\nfunction formatYear(year) {\n  return year < 0 ? \"-\" + pad(-year, 6)\n    : year > 9999 ? \"+\" + pad(year, 6)\n    : pad(year, 4);\n}\n\nfunction formatDate(date) {\n  var hours = date.getUTCHours(),\n      minutes = date.getUTCMinutes(),\n      seconds = date.getUTCSeconds(),\n      milliseconds = date.getUTCMilliseconds();\n  return isNaN(date) ? \"Invalid Date\"\n      : formatYear(date.getUTCFullYear(), 4) + \"-\" + pad(date.getUTCMonth() + 1, 2) + \"-\" + pad(date.getUTCDate(), 2)\n      + (milliseconds ? \"T\" + pad(hours, 2) + \":\" + pad(minutes, 2) + \":\" + pad(seconds, 2) + \".\" + pad(milliseconds, 3) + \"Z\"\n      : seconds ? \"T\" + pad(hours, 2) + \":\" + pad(minutes, 2) + \":\" + pad(seconds, 2) + \"Z\"\n      : minutes || hours ? \"T\" + pad(hours, 2) + \":\" + pad(minutes, 2) + \"Z\"\n      : \"\");\n}\n\nexport default function(delimiter) {\n  var reFormat = new RegExp(\"[\\\"\" + delimiter + \"\\n\\r]\"),\n      DELIMITER = delimiter.charCodeAt(0);\n\n  function parse(text, f) {\n    var convert, columns, rows = parseRows(text, function(row, i) {\n      if (convert) return convert(row, i - 1);\n      columns = row, convert = f ? customConverter(row, f) : objectConverter(row);\n    });\n    rows.columns = columns || [];\n    return rows;\n  }\n\n  function parseRows(text, f) {\n    var rows = [], // output rows\n        N = text.length,\n        I = 0, // current character index\n        n = 0, // current line number\n        t, // current token\n        eof = N <= 0, // current token followed by EOF?\n        eol = false; // current token followed by EOL?\n\n    // Strip the trailing newline.\n    if (text.charCodeAt(N - 1) === NEWLINE) --N;\n    if (text.charCodeAt(N - 1) === RETURN) --N;\n\n    function token() {\n      if (eof) return EOF;\n      if (eol) return eol = false, EOL;\n\n      // Unescape quotes.\n      var i, j = I, c;\n      if (text.charCodeAt(j) === QUOTE) {\n        while (I++ < N && text.charCodeAt(I) !== QUOTE || text.charCodeAt(++I) === QUOTE);\n        if ((i = I) >= N) eof = true;\n        else if ((c = text.charCodeAt(I++)) === NEWLINE) eol = true;\n        else if (c === RETURN) { eol = true; if (text.charCodeAt(I) === NEWLINE) ++I; }\n        return text.slice(j + 1, i - 1).replace(/\"\"/g, \"\\\"\");\n      }\n\n      // Find next delimiter or newline.\n      while (I < N) {\n        if ((c = text.charCodeAt(i = I++)) === NEWLINE) eol = true;\n        else if (c === RETURN) { eol = true; if (text.charCodeAt(I) === NEWLINE) ++I; }\n        else if (c !== DELIMITER) continue;\n        return text.slice(j, i);\n      }\n\n      // Return last token before EOF.\n      return eof = true, text.slice(j, N);\n    }\n\n    while ((t = token()) !== EOF) {\n      var row = [];\n      while (t !== EOL && t !== EOF) row.push(t), t = token();\n      if (f && (row = f(row, n++)) == null) continue;\n      rows.push(row);\n    }\n\n    return rows;\n  }\n\n  function preformatBody(rows, columns) {\n    return rows.map(function(row) {\n      return columns.map(function(column) {\n        return formatValue(row[column]);\n      }).join(delimiter);\n    });\n  }\n\n  function format(rows, columns) {\n    if (columns == null) columns = inferColumns(rows);\n    return [columns.map(formatValue).join(delimiter)].concat(preformatBody(rows, columns)).join(\"\\n\");\n  }\n\n  function formatBody(rows, columns) {\n    if (columns == null) columns = inferColumns(rows);\n    return preformatBody(rows, columns).join(\"\\n\");\n  }\n\n  function formatRows(rows) {\n    return rows.map(formatRow).join(\"\\n\");\n  }\n\n  function formatRow(row) {\n    return row.map(formatValue).join(delimiter);\n  }\n\n  function formatValue(value) {\n    return value == null ? \"\"\n        : value instanceof Date ? formatDate(value)\n        : reFormat.test(value += \"\") ? \"\\\"\" + value.replace(/\"/g, \"\\\"\\\"\") + \"\\\"\"\n        : value;\n  }\n\n  return {\n    parse: parse,\n    parseRows: parseRows,\n    format: format,\n    formatBody: formatBody,\n    formatRows: formatRows,\n    formatRow: formatRow,\n    formatValue: formatValue\n  };\n}\n","import dsv from \"./dsv.js\";\n\nvar csv = dsv(\",\");\n\nexport var csvParse = csv.parse;\nexport var csvParseRows = csv.parseRows;\nexport var csvFormat = csv.format;\nexport var csvFormatBody = csv.formatBody;\nexport var csvFormatRows = csv.formatRows;\nexport var csvFormatRow = csv.formatRow;\nexport var csvFormatValue = csv.formatValue;\n","import dsv from \"./dsv.js\";\n\nvar tsv = dsv(\"\\t\");\n\nexport var tsvParse = tsv.parse;\nexport var tsvParseRows = tsv.parseRows;\nexport var tsvFormat = tsv.format;\nexport var tsvFormatBody = tsv.formatBody;\nexport var tsvFormatRows = tsv.formatRows;\nexport var tsvFormatRow = tsv.formatRow;\nexport var tsvFormatValue = tsv.formatValue;\n","function responseText(response) {\n  if (!response.ok) throw new Error(response.status + \" \" + response.statusText);\n  return response.text();\n}\n\nexport default function(input, init) {\n  return fetch(input, init).then(responseText);\n}\n","import {csvParse, dsvFormat, tsvParse} from \"d3-dsv\";\nimport text from \"./text.js\";\n\nfunction dsvParse(parse) {\n  return function(input, init, row) {\n    if (arguments.length === 2 && typeof init === \"function\") row = init, init = undefined;\n    return text(input, init).then(function(response) {\n      return parse(response, row);\n    });\n  };\n}\n\nexport default function dsv(delimiter, input, init, row) {\n  if (arguments.length === 3 && typeof init === \"function\") row = init, init = undefined;\n  var format = dsvFormat(delimiter);\n  return text(input, init).then(function(response) {\n    return format.parse(response, row);\n  });\n}\n\nexport var csv = dsvParse(csvParse);\nexport var tsv = dsvParse(tsvParse);\n","export default function(input, init) {\n  return new Promise(function(resolve, reject) {\n    var image = new Image;\n    for (var key in init) image[key] = init[key];\n    image.onerror = reject;\n    image.onload = function() { resolve(image); };\n    image.src = input;\n  });\n}\n","function responseJson(response) {\n  if (!response.ok) throw new Error(response.status + \" \" + response.statusText);\n  if (response.status === 204 || response.status === 205) return;\n  return response.json();\n}\n\nexport default function(input, init) {\n  return fetch(input, init).then(responseJson);\n}\n","import text from \"./text.js\";\n\nfunction parser(type) {\n  return (input, init) => text(input, init)\n    .then(text => (new DOMParser).parseFromString(text, type));\n}\n\nexport default parser(\"application/xml\");\n\nexport var html = parser(\"text/html\");\n\nexport var svg = parser(\"image/svg+xml\");\n","var noop = {value: () => {}};\n\nfunction dispatch() {\n  for (var i = 0, n = arguments.length, _ = {}, t; i < n; ++i) {\n    if (!(t = arguments[i] + \"\") || (t in _) || /[\\s.]/.test(t)) throw new Error(\"illegal type: \" + t);\n    _[t] = [];\n  }\n  return new Dispatch(_);\n}\n\nfunction Dispatch(_) {\n  this._ = _;\n}\n\nfunction parseTypenames(typenames, types) {\n  return typenames.trim().split(/^|\\s+/).map(function(t) {\n    var name = \"\", i = t.indexOf(\".\");\n    if (i >= 0) name = t.slice(i + 1), t = t.slice(0, i);\n    if (t && !types.hasOwnProperty(t)) throw new Error(\"unknown type: \" + t);\n    return {type: t, name: name};\n  });\n}\n\nDispatch.prototype = dispatch.prototype = {\n  constructor: Dispatch,\n  on: function(typename, callback) {\n    var _ = this._,\n        T = parseTypenames(typename + \"\", _),\n        t,\n        i = -1,\n        n = T.length;\n\n    // If no callback was specified, return the callback of the given type and name.\n    if (arguments.length < 2) {\n      while (++i < n) if ((t = (typename = T[i]).type) && (t = get(_[t], typename.name))) return t;\n      return;\n    }\n\n    // If a type was specified, set the callback for the given type and name.\n    // Otherwise, if a null callback was specified, remove callbacks of the given name.\n    if (callback != null && typeof callback !== \"function\") throw new Error(\"invalid callback: \" + callback);\n    while (++i < n) {\n      if (t = (typename = T[i]).type) _[t] = set(_[t], typename.name, callback);\n      else if (callback == null) for (t in _) _[t] = set(_[t], typename.name, null);\n    }\n\n    return this;\n  },\n  copy: function() {\n    var copy = {}, _ = this._;\n    for (var t in _) copy[t] = _[t].slice();\n    return new Dispatch(copy);\n  },\n  call: function(type, that) {\n    if ((n = arguments.length - 2) > 0) for (var args = new Array(n), i = 0, n, t; i < n; ++i) args[i] = arguments[i + 2];\n    if (!this._.hasOwnProperty(type)) throw new Error(\"unknown type: \" + type);\n    for (t = this._[type], i = 0, n = t.length; i < n; ++i) t[i].value.apply(that, args);\n  },\n  apply: function(type, that, args) {\n    if (!this._.hasOwnProperty(type)) throw new Error(\"unknown type: \" + type);\n    for (var t = this._[type], i = 0, n = t.length; i < n; ++i) t[i].value.apply(that, args);\n  }\n};\n\nfunction get(type, name) {\n  for (var i = 0, n = type.length, c; i < n; ++i) {\n    if ((c = type[i]).name === name) {\n      return c.value;\n    }\n  }\n}\n\nfunction set(type, name, callback) {\n  for (var i = 0, n = type.length; i < n; ++i) {\n    if (type[i].name === name) {\n      type[i] = noop, type = type.slice(0, i).concat(type.slice(i + 1));\n      break;\n    }\n  }\n  if (callback != null) type.push({name: name, value: callback});\n  return type;\n}\n\nexport default dispatch;\n","export function nopropagation(event) {\n  event.stopImmediatePropagation();\n}\n\nexport default function(event) {\n  event.preventDefault();\n  event.stopImmediatePropagation();\n}\n","import {select} from \"d3-selection\";\nimport noevent from \"./noevent.js\";\n\nexport default function(view) {\n  var root = view.document.documentElement,\n      selection = select(view).on(\"dragstart.drag\", noevent, true);\n  if (\"onselectstart\" in root) {\n    selection.on(\"selectstart.drag\", noevent, true);\n  } else {\n    root.__noselect = root.style.MozUserSelect;\n    root.style.MozUserSelect = \"none\";\n  }\n}\n\nexport function yesdrag(view, noclick) {\n  var root = view.document.documentElement,\n      selection = select(view).on(\"dragstart.drag\", null);\n  if (noclick) {\n    selection.on(\"click.drag\", noevent, true);\n    setTimeout(function() { selection.on(\"click.drag\", null); }, 0);\n  }\n  if (\"onselectstart\" in root) {\n    selection.on(\"selectstart.drag\", null);\n  } else {\n    root.style.MozUserSelect = root.__noselect;\n    delete root.__noselect;\n  }\n}\n","export default function(constructor, factory, prototype) {\n  constructor.prototype = factory.prototype = prototype;\n  prototype.constructor = constructor;\n}\n\nexport function extend(parent, definition) {\n  var prototype = Object.create(parent.prototype);\n  for (var key in definition) prototype[key] = definition[key];\n  return prototype;\n}\n","import define, {extend} from \"./define.js\";\n\nexport function Color() {}\n\nexport var darker = 0.7;\nexport var brighter = 1 / darker;\n\nvar reI = \"\\\\s*([+-]?\\\\d+)\\\\s*\",\n    reN = \"\\\\s*([+-]?(?:\\\\d*\\\\.)?\\\\d+(?:[eE][+-]?\\\\d+)?)\\\\s*\",\n    reP = \"\\\\s*([+-]?(?:\\\\d*\\\\.)?\\\\d+(?:[eE][+-]?\\\\d+)?)%\\\\s*\",\n    reHex = /^#([0-9a-f]{3,8})$/,\n    reRgbInteger = new RegExp(`^rgb\\\\(${reI},${reI},${reI}\\\\)$`),\n    reRgbPercent = new RegExp(`^rgb\\\\(${reP},${reP},${reP}\\\\)$`),\n    reRgbaInteger = new RegExp(`^rgba\\\\(${reI},${reI},${reI},${reN}\\\\)$`),\n    reRgbaPercent = new RegExp(`^rgba\\\\(${reP},${reP},${reP},${reN}\\\\)$`),\n    reHslPercent = new RegExp(`^hsl\\\\(${reN},${reP},${reP}\\\\)$`),\n    reHslaPercent = new RegExp(`^hsla\\\\(${reN},${reP},${reP},${reN}\\\\)$`);\n\nvar named = {\n  aliceblue: 0xf0f8ff,\n  antiquewhite: 0xfaebd7,\n  aqua: 0x00ffff,\n  aquamarine: 0x7fffd4,\n  azure: 0xf0ffff,\n  beige: 0xf5f5dc,\n  bisque: 0xffe4c4,\n  black: 0x000000,\n  blanchedalmond: 0xffebcd,\n  blue: 0x0000ff,\n  blueviolet: 0x8a2be2,\n  brown: 0xa52a2a,\n  burlywood: 0xdeb887,\n  cadetblue: 0x5f9ea0,\n  chartreuse: 0x7fff00,\n  chocolate: 0xd2691e,\n  coral: 0xff7f50,\n  cornflowerblue: 0x6495ed,\n  cornsilk: 0xfff8dc,\n  crimson: 0xdc143c,\n  cyan: 0x00ffff,\n  darkblue: 0x00008b,\n  darkcyan: 0x008b8b,\n  darkgoldenrod: 0xb8860b,\n  darkgray: 0xa9a9a9,\n  darkgreen: 0x006400,\n  darkgrey: 0xa9a9a9,\n  darkkhaki: 0xbdb76b,\n  darkmagenta: 0x8b008b,\n  darkolivegreen: 0x556b2f,\n  darkorange: 0xff8c00,\n  darkorchid: 0x9932cc,\n  darkred: 0x8b0000,\n  darksalmon: 0xe9967a,\n  darkseagreen: 0x8fbc8f,\n  darkslateblue: 0x483d8b,\n  darkslategray: 0x2f4f4f,\n  darkslategrey: 0x2f4f4f,\n  darkturquoise: 0x00ced1,\n  darkviolet: 0x9400d3,\n  deeppink: 0xff1493,\n  deepskyblue: 0x00bfff,\n  dimgray: 0x696969,\n  dimgrey: 0x696969,\n  dodgerblue: 0x1e90ff,\n  firebrick: 0xb22222,\n  floralwhite: 0xfffaf0,\n  forestgreen: 0x228b22,\n  fuchsia: 0xff00ff,\n  gainsboro: 0xdcdcdc,\n  ghostwhite: 0xf8f8ff,\n  gold: 0xffd700,\n  goldenrod: 0xdaa520,\n  gray: 0x808080,\n  green: 0x008000,\n  greenyellow: 0xadff2f,\n  grey: 0x808080,\n  honeydew: 0xf0fff0,\n  hotpink: 0xff69b4,\n  indianred: 0xcd5c5c,\n  indigo: 0x4b0082,\n  ivory: 0xfffff0,\n  khaki: 0xf0e68c,\n  lavender: 0xe6e6fa,\n  lavenderblush: 0xfff0f5,\n  lawngreen: 0x7cfc00,\n  lemonchiffon: 0xfffacd,\n  lightblue: 0xadd8e6,\n  lightcoral: 0xf08080,\n  lightcyan: 0xe0ffff,\n  lightgoldenrodyellow: 0xfafad2,\n  lightgray: 0xd3d3d3,\n  lightgreen: 0x90ee90,\n  lightgrey: 0xd3d3d3,\n  lightpink: 0xffb6c1,\n  lightsalmon: 0xffa07a,\n  lightseagreen: 0x20b2aa,\n  lightskyblue: 0x87cefa,\n  lightslategray: 0x778899,\n  lightslategrey: 0x778899,\n  lightsteelblue: 0xb0c4de,\n  lightyellow: 0xffffe0,\n  lime: 0x00ff00,\n  limegreen: 0x32cd32,\n  linen: 0xfaf0e6,\n  magenta: 0xff00ff,\n  maroon: 0x800000,\n  mediumaquamarine: 0x66cdaa,\n  mediumblue: 0x0000cd,\n  mediumorchid: 0xba55d3,\n  mediumpurple: 0x9370db,\n  mediumseagreen: 0x3cb371,\n  mediumslateblue: 0x7b68ee,\n  mediumspringgreen: 0x00fa9a,\n  mediumturquoise: 0x48d1cc,\n  mediumvioletred: 0xc71585,\n  midnightblue: 0x191970,\n  mintcream: 0xf5fffa,\n  mistyrose: 0xffe4e1,\n  moccasin: 0xffe4b5,\n  navajowhite: 0xffdead,\n  navy: 0x000080,\n  oldlace: 0xfdf5e6,\n  olive: 0x808000,\n  olivedrab: 0x6b8e23,\n  orange: 0xffa500,\n  orangered: 0xff4500,\n  orchid: 0xda70d6,\n  palegoldenrod: 0xeee8aa,\n  palegreen: 0x98fb98,\n  paleturquoise: 0xafeeee,\n  palevioletred: 0xdb7093,\n  papayawhip: 0xffefd5,\n  peachpuff: 0xffdab9,\n  peru: 0xcd853f,\n  pink: 0xffc0cb,\n  plum: 0xdda0dd,\n  powderblue: 0xb0e0e6,\n  purple: 0x800080,\n  rebeccapurple: 0x663399,\n  red: 0xff0000,\n  rosybrown: 0xbc8f8f,\n  royalblue: 0x4169e1,\n  saddlebrown: 0x8b4513,\n  salmon: 0xfa8072,\n  sandybrown: 0xf4a460,\n  seagreen: 0x2e8b57,\n  seashell: 0xfff5ee,\n  sienna: 0xa0522d,\n  silver: 0xc0c0c0,\n  skyblue: 0x87ceeb,\n  slateblue: 0x6a5acd,\n  slategray: 0x708090,\n  slategrey: 0x708090,\n  snow: 0xfffafa,\n  springgreen: 0x00ff7f,\n  steelblue: 0x4682b4,\n  tan: 0xd2b48c,\n  teal: 0x008080,\n  thistle: 0xd8bfd8,\n  tomato: 0xff6347,\n  turquoise: 0x40e0d0,\n  violet: 0xee82ee,\n  wheat: 0xf5deb3,\n  white: 0xffffff,\n  whitesmoke: 0xf5f5f5,\n  yellow: 0xffff00,\n  yellowgreen: 0x9acd32\n};\n\ndefine(Color, color, {\n  copy(channels) {\n    return Object.assign(new this.constructor, this, channels);\n  },\n  displayable() {\n    return this.rgb().displayable();\n  },\n  hex: color_formatHex, // Deprecated! Use color.formatHex.\n  formatHex: color_formatHex,\n  formatHex8: color_formatHex8,\n  formatHsl: color_formatHsl,\n  formatRgb: color_formatRgb,\n  toString: color_formatRgb\n});\n\nfunction color_formatHex() {\n  return this.rgb().formatHex();\n}\n\nfunction color_formatHex8() {\n  return this.rgb().formatHex8();\n}\n\nfunction color_formatHsl() {\n  return hslConvert(this).formatHsl();\n}\n\nfunction color_formatRgb() {\n  return this.rgb().formatRgb();\n}\n\nexport default function color(format) {\n  var m, l;\n  format = (format + \"\").trim().toLowerCase();\n  return (m = reHex.exec(format)) ? (l = m[1].length, m = parseInt(m[1], 16), l === 6 ? rgbn(m) // #ff0000\n      : l === 3 ? new Rgb((m >> 8 & 0xf) | (m >> 4 & 0xf0), (m >> 4 & 0xf) | (m & 0xf0), ((m & 0xf) << 4) | (m & 0xf), 1) // #f00\n      : l === 8 ? rgba(m >> 24 & 0xff, m >> 16 & 0xff, m >> 8 & 0xff, (m & 0xff) / 0xff) // #ff000000\n      : l === 4 ? rgba((m >> 12 & 0xf) | (m >> 8 & 0xf0), (m >> 8 & 0xf) | (m >> 4 & 0xf0), (m >> 4 & 0xf) | (m & 0xf0), (((m & 0xf) << 4) | (m & 0xf)) / 0xff) // #f000\n      : null) // invalid hex\n      : (m = reRgbInteger.exec(format)) ? new Rgb(m[1], m[2], m[3], 1) // rgb(255, 0, 0)\n      : (m = reRgbPercent.exec(format)) ? new Rgb(m[1] * 255 / 100, m[2] * 255 / 100, m[3] * 255 / 100, 1) // rgb(100%, 0%, 0%)\n      : (m = reRgbaInteger.exec(format)) ? rgba(m[1], m[2], m[3], m[4]) // rgba(255, 0, 0, 1)\n      : (m = reRgbaPercent.exec(format)) ? rgba(m[1] * 255 / 100, m[2] * 255 / 100, m[3] * 255 / 100, m[4]) // rgb(100%, 0%, 0%, 1)\n      : (m = reHslPercent.exec(format)) ? hsla(m[1], m[2] / 100, m[3] / 100, 1) // hsl(120, 50%, 50%)\n      : (m = reHslaPercent.exec(format)) ? hsla(m[1], m[2] / 100, m[3] / 100, m[4]) // hsla(120, 50%, 50%, 1)\n      : named.hasOwnProperty(format) ? rgbn(named[format]) // eslint-disable-line no-prototype-builtins\n      : format === \"transparent\" ? new Rgb(NaN, NaN, NaN, 0)\n      : null;\n}\n\nfunction rgbn(n) {\n  return new Rgb(n >> 16 & 0xff, n >> 8 & 0xff, n & 0xff, 1);\n}\n\nfunction rgba(r, g, b, a) {\n  if (a <= 0) r = g = b = NaN;\n  return new Rgb(r, g, b, a);\n}\n\nexport function rgbConvert(o) {\n  if (!(o instanceof Color)) o = color(o);\n  if (!o) return new Rgb;\n  o = o.rgb();\n  return new Rgb(o.r, o.g, o.b, o.opacity);\n}\n\nexport function rgb(r, g, b, opacity) {\n  return arguments.length === 1 ? rgbConvert(r) : new Rgb(r, g, b, opacity == null ? 1 : opacity);\n}\n\nexport function Rgb(r, g, b, opacity) {\n  this.r = +r;\n  this.g = +g;\n  this.b = +b;\n  this.opacity = +opacity;\n}\n\ndefine(Rgb, rgb, extend(Color, {\n  brighter(k) {\n    k = k == null ? brighter : Math.pow(brighter, k);\n    return new Rgb(this.r * k, this.g * k, this.b * k, this.opacity);\n  },\n  darker(k) {\n    k = k == null ? darker : Math.pow(darker, k);\n    return new Rgb(this.r * k, this.g * k, this.b * k, this.opacity);\n  },\n  rgb() {\n    return this;\n  },\n  clamp() {\n    return new Rgb(clampi(this.r), clampi(this.g), clampi(this.b), clampa(this.opacity));\n  },\n  displayable() {\n    return (-0.5 <= this.r && this.r < 255.5)\n        && (-0.5 <= this.g && this.g < 255.5)\n        && (-0.5 <= this.b && this.b < 255.5)\n        && (0 <= this.opacity && this.opacity <= 1);\n  },\n  hex: rgb_formatHex, // Deprecated! Use color.formatHex.\n  formatHex: rgb_formatHex,\n  formatHex8: rgb_formatHex8,\n  formatRgb: rgb_formatRgb,\n  toString: rgb_formatRgb\n}));\n\nfunction rgb_formatHex() {\n  return `#${hex(this.r)}${hex(this.g)}${hex(this.b)}`;\n}\n\nfunction rgb_formatHex8() {\n  return `#${hex(this.r)}${hex(this.g)}${hex(this.b)}${hex((isNaN(this.opacity) ? 1 : this.opacity) * 255)}`;\n}\n\nfunction rgb_formatRgb() {\n  const a = clampa(this.opacity);\n  return `${a === 1 ? \"rgb(\" : \"rgba(\"}${clampi(this.r)}, ${clampi(this.g)}, ${clampi(this.b)}${a === 1 ? \")\" : `, ${a})`}`;\n}\n\nfunction clampa(opacity) {\n  return isNaN(opacity) ? 1 : Math.max(0, Math.min(1, opacity));\n}\n\nfunction clampi(value) {\n  return Math.max(0, Math.min(255, Math.round(value) || 0));\n}\n\nfunction hex(value) {\n  value = clampi(value);\n  return (value < 16 ? \"0\" : \"\") + value.toString(16);\n}\n\nfunction hsla(h, s, l, a) {\n  if (a <= 0) h = s = l = NaN;\n  else if (l <= 0 || l >= 1) h = s = NaN;\n  else if (s <= 0) h = NaN;\n  return new Hsl(h, s, l, a);\n}\n\nexport function hslConvert(o) {\n  if (o instanceof Hsl) return new Hsl(o.h, o.s, o.l, o.opacity);\n  if (!(o instanceof Color)) o = color(o);\n  if (!o) return new Hsl;\n  if (o instanceof Hsl) return o;\n  o = o.rgb();\n  var r = o.r / 255,\n      g = o.g / 255,\n      b = o.b / 255,\n      min = Math.min(r, g, b),\n      max = Math.max(r, g, b),\n      h = NaN,\n      s = max - min,\n      l = (max + min) / 2;\n  if (s) {\n    if (r === max) h = (g - b) / s + (g < b) * 6;\n    else if (g === max) h = (b - r) / s + 2;\n    else h = (r - g) / s + 4;\n    s /= l < 0.5 ? max + min : 2 - max - min;\n    h *= 60;\n  } else {\n    s = l > 0 && l < 1 ? 0 : h;\n  }\n  return new Hsl(h, s, l, o.opacity);\n}\n\nexport function hsl(h, s, l, opacity) {\n  return arguments.length === 1 ? hslConvert(h) : new Hsl(h, s, l, opacity == null ? 1 : opacity);\n}\n\nfunction Hsl(h, s, l, opacity) {\n  this.h = +h;\n  this.s = +s;\n  this.l = +l;\n  this.opacity = +opacity;\n}\n\ndefine(Hsl, hsl, extend(Color, {\n  brighter(k) {\n    k = k == null ? brighter : Math.pow(brighter, k);\n    return new Hsl(this.h, this.s, this.l * k, this.opacity);\n  },\n  darker(k) {\n    k = k == null ? darker : Math.pow(darker, k);\n    return new Hsl(this.h, this.s, this.l * k, this.opacity);\n  },\n  rgb() {\n    var h = this.h % 360 + (this.h < 0) * 360,\n        s = isNaN(h) || isNaN(this.s) ? 0 : this.s,\n        l = this.l,\n        m2 = l + (l < 0.5 ? l : 1 - l) * s,\n        m1 = 2 * l - m2;\n    return new Rgb(\n      hsl2rgb(h >= 240 ? h - 240 : h + 120, m1, m2),\n      hsl2rgb(h, m1, m2),\n      hsl2rgb(h < 120 ? h + 240 : h - 120, m1, m2),\n      this.opacity\n    );\n  },\n  clamp() {\n    return new Hsl(clamph(this.h), clampt(this.s), clampt(this.l), clampa(this.opacity));\n  },\n  displayable() {\n    return (0 <= this.s && this.s <= 1 || isNaN(this.s))\n        && (0 <= this.l && this.l <= 1)\n        && (0 <= this.opacity && this.opacity <= 1);\n  },\n  formatHsl() {\n    const a = clampa(this.opacity);\n    return `${a === 1 ? \"hsl(\" : \"hsla(\"}${clamph(this.h)}, ${clampt(this.s) * 100}%, ${clampt(this.l) * 100}%${a === 1 ? \")\" : `, ${a})`}`;\n  }\n}));\n\nfunction clamph(value) {\n  value = (value || 0) % 360;\n  return value < 0 ? value + 360 : value;\n}\n\nfunction clampt(value) {\n  return Math.max(0, Math.min(1, value || 0));\n}\n\n/* From FvD 13.37, CSS Color Module Level 3 */\nfunction hsl2rgb(h, m1, m2) {\n  return (h < 60 ? m1 + (m2 - m1) * h / 60\n      : h < 180 ? m2\n      : h < 240 ? m1 + (m2 - m1) * (240 - h) / 60\n      : m1) * 255;\n}\n","export function basis(t1, v0, v1, v2, v3) {\n  var t2 = t1 * t1, t3 = t2 * t1;\n  return ((1 - 3 * t1 + 3 * t2 - t3) * v0\n      + (4 - 6 * t2 + 3 * t3) * v1\n      + (1 + 3 * t1 + 3 * t2 - 3 * t3) * v2\n      + t3 * v3) / 6;\n}\n\nexport default function(values) {\n  var n = values.length - 1;\n  return function(t) {\n    var i = t <= 0 ? (t = 0) : t >= 1 ? (t = 1, n - 1) : Math.floor(t * n),\n        v1 = values[i],\n        v2 = values[i + 1],\n        v0 = i > 0 ? values[i - 1] : 2 * v1 - v2,\n        v3 = i < n - 1 ? values[i + 2] : 2 * v2 - v1;\n    return basis((t - i / n) * n, v0, v1, v2, v3);\n  };\n}\n","export default x => () => x;\n","import constant from \"./constant.js\";\n\nfunction linear(a, d) {\n  return function(t) {\n    return a + t * d;\n  };\n}\n\nfunction exponential(a, b, y) {\n  return a = Math.pow(a, y), b = Math.pow(b, y) - a, y = 1 / y, function(t) {\n    return Math.pow(a + t * b, y);\n  };\n}\n\nexport function hue(a, b) {\n  var d = b - a;\n  return d ? linear(a, d > 180 || d < -180 ? d - 360 * Math.round(d / 360) : d) : constant(isNaN(a) ? b : a);\n}\n\nexport function gamma(y) {\n  return (y = +y) === 1 ? nogamma : function(a, b) {\n    return b - a ? exponential(a, b, y) : constant(isNaN(a) ? b : a);\n  };\n}\n\nexport default function nogamma(a, b) {\n  var d = b - a;\n  return d ? linear(a, d) : constant(isNaN(a) ? b : a);\n}\n","import {rgb as colorRgb} from \"d3-color\";\nimport basis from \"./basis.js\";\nimport basisClosed from \"./basisClosed.js\";\nimport nogamma, {gamma} from \"./color.js\";\n\nexport default (function rgbGamma(y) {\n  var color = gamma(y);\n\n  function rgb(start, end) {\n    var r = color((start = colorRgb(start)).r, (end = colorRgb(end)).r),\n        g = color(start.g, end.g),\n        b = color(start.b, end.b),\n        opacity = nogamma(start.opacity, end.opacity);\n    return function(t) {\n      start.r = r(t);\n      start.g = g(t);\n      start.b = b(t);\n      start.opacity = opacity(t);\n      return start + \"\";\n    };\n  }\n\n  rgb.gamma = rgbGamma;\n\n  return rgb;\n})(1);\n\nfunction rgbSpline(spline) {\n  return function(colors) {\n    var n = colors.length,\n        r = new Array(n),\n        g = new Array(n),\n        b = new Array(n),\n        i, color;\n    for (i = 0; i < n; ++i) {\n      color = colorRgb(colors[i]);\n      r[i] = color.r || 0;\n      g[i] = color.g || 0;\n      b[i] = color.b || 0;\n    }\n    r = spline(r);\n    g = spline(g);\n    b = spline(b);\n    color.opacity = 1;\n    return function(t) {\n      color.r = r(t);\n      color.g = g(t);\n      color.b = b(t);\n      return color + \"\";\n    };\n  };\n}\n\nexport var rgbBasis = rgbSpline(basis);\nexport var rgbBasisClosed = rgbSpline(basisClosed);\n","import value from \"./value.js\";\nimport numberArray, {isNumberArray} from \"./numberArray.js\";\n\nexport default function(a, b) {\n  return (isNumberArray(b) ? numberArray : genericArray)(a, b);\n}\n\nexport function genericArray(a, b) {\n  var nb = b ? b.length : 0,\n      na = a ? Math.min(nb, a.length) : 0,\n      x = new Array(na),\n      c = new Array(nb),\n      i;\n\n  for (i = 0; i < na; ++i) x[i] = value(a[i], b[i]);\n  for (; i < nb; ++i) c[i] = b[i];\n\n  return function(t) {\n    for (i = 0; i < na; ++i) c[i] = x[i](t);\n    return c;\n  };\n}\n","export default function(a, b) {\n  var d = new Date;\n  return a = +a, b = +b, function(t) {\n    return d.setTime(a * (1 - t) + b * t), d;\n  };\n}\n","export default function(a, b) {\n  return a = +a, b = +b, function(t) {\n    return a * (1 - t) + b * t;\n  };\n}\n","import value from \"./value.js\";\n\nexport default function(a, b) {\n  var i = {},\n      c = {},\n      k;\n\n  if (a === null || typeof a !== \"object\") a = {};\n  if (b === null || typeof b !== \"object\") b = {};\n\n  for (k in b) {\n    if (k in a) {\n      i[k] = value(a[k], b[k]);\n    } else {\n      c[k] = b[k];\n    }\n  }\n\n  return function(t) {\n    for (k in i) c[k] = i[k](t);\n    return c;\n  };\n}\n","import {basis} from \"./basis.js\";\n\nexport default function(values) {\n  var n = values.length;\n  return function(t) {\n    var i = Math.floor(((t %= 1) < 0 ? ++t : t) * n),\n        v0 = values[(i + n - 1) % n],\n        v1 = values[i % n],\n        v2 = values[(i + 1) % n],\n        v3 = values[(i + 2) % n];\n    return basis((t - i / n) * n, v0, v1, v2, v3);\n  };\n}\n","import number from \"./number.js\";\n\nvar reA = /[-+]?(?:\\d+\\.?\\d*|\\.?\\d+)(?:[eE][-+]?\\d+)?/g,\n    reB = new RegExp(reA.source, \"g\");\n\nfunction zero(b) {\n  return function() {\n    return b;\n  };\n}\n\nfunction one(b) {\n  return function(t) {\n    return b(t) + \"\";\n  };\n}\n\nexport default function(a, b) {\n  var bi = reA.lastIndex = reB.lastIndex = 0, // scan index for next number in b\n      am, // current match in a\n      bm, // current match in b\n      bs, // string preceding current number in b, if any\n      i = -1, // index in s\n      s = [], // string constants and placeholders\n      q = []; // number interpolators\n\n  // Coerce inputs to strings.\n  a = a + \"\", b = b + \"\";\n\n  // Interpolate pairs of numbers in a & b.\n  while ((am = reA.exec(a))\n      && (bm = reB.exec(b))) {\n    if ((bs = bm.index) > bi) { // a string precedes the next number in b\n      bs = b.slice(bi, bs);\n      if (s[i]) s[i] += bs; // coalesce with previous string\n      else s[++i] = bs;\n    }\n    if ((am = am[0]) === (bm = bm[0])) { // numbers in a & b match\n      if (s[i]) s[i] += bm; // coalesce with previous string\n      else s[++i] = bm;\n    } else { // interpolate non-matching numbers\n      s[++i] = null;\n      q.push({i: i, x: number(am, bm)});\n    }\n    bi = reB.lastIndex;\n  }\n\n  // Add remains of b.\n  if (bi < b.length) {\n    bs = b.slice(bi);\n    if (s[i]) s[i] += bs; // coalesce with previous string\n    else s[++i] = bs;\n  }\n\n  // Special optimization for only a single match.\n  // Otherwise, interpolate each of the numbers and rejoin the string.\n  return s.length < 2 ? (q[0]\n      ? one(q[0].x)\n      : zero(b))\n      : (b = q.length, function(t) {\n          for (var i = 0, o; i < b; ++i) s[(o = q[i]).i] = o.x(t);\n          return s.join(\"\");\n        });\n}\n","export default function(a, b) {\n  if (!b) b = [];\n  var n = a ? Math.min(b.length, a.length) : 0,\n      c = b.slice(),\n      i;\n  return function(t) {\n    for (i = 0; i < n; ++i) c[i] = a[i] * (1 - t) + b[i] * t;\n    return c;\n  };\n}\n\nexport function isNumberArray(x) {\n  return ArrayBuffer.isView(x) && !(x instanceof DataView);\n}\n","import {color} from \"d3-color\";\nimport rgb from \"./rgb.js\";\nimport {genericArray} from \"./array.js\";\nimport date from \"./date.js\";\nimport number from \"./number.js\";\nimport object from \"./object.js\";\nimport string from \"./string.js\";\nimport constant from \"./constant.js\";\nimport numberArray, {isNumberArray} from \"./numberArray.js\";\n\nexport default function(a, b) {\n  var t = typeof b, c;\n  return b == null || t === \"boolean\" ? constant(b)\n      : (t === \"number\" ? number\n      : t === \"string\" ? ((c = color(b)) ? (b = c, rgb) : string)\n      : b instanceof color ? rgb\n      : b instanceof Date ? date\n      : isNumberArray(b) ? numberArray\n      : Array.isArray(b) ? genericArray\n      : typeof b.valueOf !== \"function\" && typeof b.toString !== \"function\" || isNaN(b) ? object\n      : number)(a, b);\n}\n","function none() {}\n\nexport default function(selector) {\n  return selector == null ? none : function() {\n    return this.querySelector(selector);\n  };\n}\n","// Given something array like (or null), returns something that is strictly an\n// array. This is used to ensure that array-like objects passed to d3.selectAll\n// or selection.selectAll are converted into proper arrays when creating a\n// selection; we don’t ever want to create a selection backed by a live\n// HTMLCollection or NodeList. However, note that selection.selectAll will use a\n// static NodeList as a group, since it safely derived from querySelectorAll.\nexport default function array(x) {\n  return x == null ? [] : Array.isArray(x) ? x : Array.from(x);\n}\n","function empty() {\n  return [];\n}\n\nexport default function(selector) {\n  return selector == null ? empty : function() {\n    return this.querySelectorAll(selector);\n  };\n}\n","export default function(selector) {\n  return function() {\n    return this.matches(selector);\n  };\n}\n\nexport function childMatcher(selector) {\n  return function(node) {\n    return node.matches(selector);\n  };\n}\n\n","import {childMatcher} from \"../matcher.js\";\n\nvar find = Array.prototype.find;\n\nfunction childFind(match) {\n  return function() {\n    return find.call(this.children, match);\n  };\n}\n\nfunction childFirst() {\n  return this.firstElementChild;\n}\n\nexport default function(match) {\n  return this.select(match == null ? childFirst\n      : childFind(typeof match === \"function\" ? match : childMatcher(match)));\n}\n","import {childMatcher} from \"../matcher.js\";\n\nvar filter = Array.prototype.filter;\n\nfunction children() {\n  return Array.from(this.children);\n}\n\nfunction childrenFilter(match) {\n  return function() {\n    return filter.call(this.children, match);\n  };\n}\n\nexport default function(match) {\n  return this.selectAll(match == null ? children\n      : childrenFilter(typeof match === \"function\" ? match : childMatcher(match)));\n}\n","export default function(update) {\n  return new Array(update.length);\n}\n","import sparse from \"./sparse.js\";\nimport {Selection} from \"./index.js\";\n\nexport default function() {\n  return new Selection(this._enter || this._groups.map(sparse), this._parents);\n}\n\nexport function EnterNode(parent, datum) {\n  this.ownerDocument = parent.ownerDocument;\n  this.namespaceURI = parent.namespaceURI;\n  this._next = null;\n  this._parent = parent;\n  this.__data__ = datum;\n}\n\nEnterNode.prototype = {\n  constructor: EnterNode,\n  appendChild: function(child) { return this._parent.insertBefore(child, this._next); },\n  insertBefore: function(child, next) { return this._parent.insertBefore(child, next); },\n  querySelector: function(selector) { return this._parent.querySelector(selector); },\n  querySelectorAll: function(selector) { return this._parent.querySelectorAll(selector); }\n};\n","export default function(x) {\n  return function() {\n    return x;\n  };\n}\n","import {Selection} from \"./index.js\";\nimport {EnterNode} from \"./enter.js\";\nimport constant from \"../constant.js\";\n\nfunction bindIndex(parent, group, enter, update, exit, data) {\n  var i = 0,\n      node,\n      groupLength = group.length,\n      dataLength = data.length;\n\n  // Put any non-null nodes that fit into update.\n  // Put any null nodes into enter.\n  // Put any remaining data into enter.\n  for (; i < dataLength; ++i) {\n    if (node = group[i]) {\n      node.__data__ = data[i];\n      update[i] = node;\n    } else {\n      enter[i] = new EnterNode(parent, data[i]);\n    }\n  }\n\n  // Put any non-null nodes that don’t fit into exit.\n  for (; i < groupLength; ++i) {\n    if (node = group[i]) {\n      exit[i] = node;\n    }\n  }\n}\n\nfunction bindKey(parent, group, enter, update, exit, data, key) {\n  var i,\n      node,\n      nodeByKeyValue = new Map,\n      groupLength = group.length,\n      dataLength = data.length,\n      keyValues = new Array(groupLength),\n      keyValue;\n\n  // Compute the key for each node.\n  // If multiple nodes have the same key, the duplicates are added to exit.\n  for (i = 0; i < groupLength; ++i) {\n    if (node = group[i]) {\n      keyValues[i] = keyValue = key.call(node, node.__data__, i, group) + \"\";\n      if (nodeByKeyValue.has(keyValue)) {\n        exit[i] = node;\n      } else {\n        nodeByKeyValue.set(keyValue, node);\n      }\n    }\n  }\n\n  // Compute the key for each datum.\n  // If there a node associated with this key, join and add it to update.\n  // If there is not (or the key is a duplicate), add it to enter.\n  for (i = 0; i < dataLength; ++i) {\n    keyValue = key.call(parent, data[i], i, data) + \"\";\n    if (node = nodeByKeyValue.get(keyValue)) {\n      update[i] = node;\n      node.__data__ = data[i];\n      nodeByKeyValue.delete(keyValue);\n    } else {\n      enter[i] = new EnterNode(parent, data[i]);\n    }\n  }\n\n  // Add any remaining nodes that were not bound to data to exit.\n  for (i = 0; i < groupLength; ++i) {\n    if ((node = group[i]) && (nodeByKeyValue.get(keyValues[i]) === node)) {\n      exit[i] = node;\n    }\n  }\n}\n\nfunction datum(node) {\n  return node.__data__;\n}\n\nexport default function(value, key) {\n  if (!arguments.length) return Array.from(this, datum);\n\n  var bind = key ? bindKey : bindIndex,\n      parents = this._parents,\n      groups = this._groups;\n\n  if (typeof value !== \"function\") value = constant(value);\n\n  for (var m = groups.length, update = new Array(m), enter = new Array(m), exit = new Array(m), j = 0; j < m; ++j) {\n    var parent = parents[j],\n        group = groups[j],\n        groupLength = group.length,\n        data = arraylike(value.call(parent, parent && parent.__data__, j, parents)),\n        dataLength = data.length,\n        enterGroup = enter[j] = new Array(dataLength),\n        updateGroup = update[j] = new Array(dataLength),\n        exitGroup = exit[j] = new Array(groupLength);\n\n    bind(parent, group, enterGroup, updateGroup, exitGroup, data, key);\n\n    // Now connect the enter nodes to their following update node, such that\n    // appendChild can insert the materialized enter node before this node,\n    // rather than at the end of the parent node.\n    for (var i0 = 0, i1 = 0, previous, next; i0 < dataLength; ++i0) {\n      if (previous = enterGroup[i0]) {\n        if (i0 >= i1) i1 = i0 + 1;\n        while (!(next = updateGroup[i1]) && ++i1 < dataLength);\n        previous._next = next || null;\n      }\n    }\n  }\n\n  update = new Selection(update, parents);\n  update._enter = enter;\n  update._exit = exit;\n  return update;\n}\n\n// Given some data, this returns an array-like view of it: an object that\n// exposes a length property and allows numeric indexing. Note that unlike\n// selectAll, this isn’t worried about “live” collections because the resulting\n// array will only be used briefly while data is being bound. (It is possible to\n// cause the data to change while iterating by using a key function, but please\n// don’t; we’d rather avoid a gratuitous copy.)\nfunction arraylike(data) {\n  return typeof data === \"object\" && \"length\" in data\n    ? data // Array, TypedArray, NodeList, array-like\n    : Array.from(data); // Map, Set, iterable, string, or anything else\n}\n","import {Selection} from \"./index.js\";\n\nexport default function(compare) {\n  if (!compare) compare = ascending;\n\n  function compareNode(a, b) {\n    return a && b ? compare(a.__data__, b.__data__) : !a - !b;\n  }\n\n  for (var groups = this._groups, m = groups.length, sortgroups = new Array(m), j = 0; j < m; ++j) {\n    for (var group = groups[j], n = group.length, sortgroup = sortgroups[j] = new Array(n), node, i = 0; i < n; ++i) {\n      if (node = group[i]) {\n        sortgroup[i] = node;\n      }\n    }\n    sortgroup.sort(compareNode);\n  }\n\n  return new Selection(sortgroups, this._parents).order();\n}\n\nfunction ascending(a, b) {\n  return a < b ? -1 : a > b ? 1 : a >= b ? 0 : NaN;\n}\n","export var xhtml = \"http://www.w3.org/1999/xhtml\";\n\nexport default {\n  svg: \"http://www.w3.org/2000/svg\",\n  xhtml: xhtml,\n  xlink: \"http://www.w3.org/1999/xlink\",\n  xml: \"http://www.w3.org/XML/1998/namespace\",\n  xmlns: \"http://www.w3.org/2000/xmlns/\"\n};\n","import namespaces from \"./namespaces.js\";\n\nexport default function(name) {\n  var prefix = name += \"\", i = prefix.indexOf(\":\");\n  if (i >= 0 && (prefix = name.slice(0, i)) !== \"xmlns\") name = name.slice(i + 1);\n  return namespaces.hasOwnProperty(prefix) ? {space: namespaces[prefix], local: name} : name; // eslint-disable-line no-prototype-builtins\n}\n","import namespace from \"../namespace.js\";\n\nfunction attrRemove(name) {\n  return function() {\n    this.removeAttribute(name);\n  };\n}\n\nfunction attrRemoveNS(fullname) {\n  return function() {\n    this.removeAttributeNS(fullname.space, fullname.local);\n  };\n}\n\nfunction attrConstant(name, value) {\n  return function() {\n    this.setAttribute(name, value);\n  };\n}\n\nfunction attrConstantNS(fullname, value) {\n  return function() {\n    this.setAttributeNS(fullname.space, fullname.local, value);\n  };\n}\n\nfunction attrFunction(name, value) {\n  return function() {\n    var v = value.apply(this, arguments);\n    if (v == null) this.removeAttribute(name);\n    else this.setAttribute(name, v);\n  };\n}\n\nfunction attrFunctionNS(fullname, value) {\n  return function() {\n    var v = value.apply(this, arguments);\n    if (v == null) this.removeAttributeNS(fullname.space, fullname.local);\n    else this.setAttributeNS(fullname.space, fullname.local, v);\n  };\n}\n\nexport default function(name, value) {\n  var fullname = namespace(name);\n\n  if (arguments.length < 2) {\n    var node = this.node();\n    return fullname.local\n        ? node.getAttributeNS(fullname.space, fullname.local)\n        : node.getAttribute(fullname);\n  }\n\n  return this.each((value == null\n      ? (fullname.local ? attrRemoveNS : attrRemove) : (typeof value === \"function\"\n      ? (fullname.local ? attrFunctionNS : attrFunction)\n      : (fullname.local ? attrConstantNS : attrConstant)))(fullname, value));\n}\n","export default function(node) {\n  return (node.ownerDocument && node.ownerDocument.defaultView) // node is a Node\n      || (node.document && node) // node is a Window\n      || node.defaultView; // node is a Document\n}\n","import defaultView from \"../window.js\";\n\nfunction styleRemove(name) {\n  return function() {\n    this.style.removeProperty(name);\n  };\n}\n\nfunction styleConstant(name, value, priority) {\n  return function() {\n    this.style.setProperty(name, value, priority);\n  };\n}\n\nfunction styleFunction(name, value, priority) {\n  return function() {\n    var v = value.apply(this, arguments);\n    if (v == null) this.style.removeProperty(name);\n    else this.style.setProperty(name, v, priority);\n  };\n}\n\nexport default function(name, value, priority) {\n  return arguments.length > 1\n      ? this.each((value == null\n            ? styleRemove : typeof value === \"function\"\n            ? styleFunction\n            : styleConstant)(name, value, priority == null ? \"\" : priority))\n      : styleValue(this.node(), name);\n}\n\nexport function styleValue(node, name) {\n  return node.style.getPropertyValue(name)\n      || defaultView(node).getComputedStyle(node, null).getPropertyValue(name);\n}\n","function propertyRemove(name) {\n  return function() {\n    delete this[name];\n  };\n}\n\nfunction propertyConstant(name, value) {\n  return function() {\n    this[name] = value;\n  };\n}\n\nfunction propertyFunction(name, value) {\n  return function() {\n    var v = value.apply(this, arguments);\n    if (v == null) delete this[name];\n    else this[name] = v;\n  };\n}\n\nexport default function(name, value) {\n  return arguments.length > 1\n      ? this.each((value == null\n          ? propertyRemove : typeof value === \"function\"\n          ? propertyFunction\n          : propertyConstant)(name, value))\n      : this.node()[name];\n}\n","function classArray(string) {\n  return string.trim().split(/^|\\s+/);\n}\n\nfunction classList(node) {\n  return node.classList || new ClassList(node);\n}\n\nfunction ClassList(node) {\n  this._node = node;\n  this._names = classArray(node.getAttribute(\"class\") || \"\");\n}\n\nClassList.prototype = {\n  add: function(name) {\n    var i = this._names.indexOf(name);\n    if (i < 0) {\n      this._names.push(name);\n      this._node.setAttribute(\"class\", this._names.join(\" \"));\n    }\n  },\n  remove: function(name) {\n    var i = this._names.indexOf(name);\n    if (i >= 0) {\n      this._names.splice(i, 1);\n      this._node.setAttribute(\"class\", this._names.join(\" \"));\n    }\n  },\n  contains: function(name) {\n    return this._names.indexOf(name) >= 0;\n  }\n};\n\nfunction classedAdd(node, names) {\n  var list = classList(node), i = -1, n = names.length;\n  while (++i < n) list.add(names[i]);\n}\n\nfunction classedRemove(node, names) {\n  var list = classList(node), i = -1, n = names.length;\n  while (++i < n) list.remove(names[i]);\n}\n\nfunction classedTrue(names) {\n  return function() {\n    classedAdd(this, names);\n  };\n}\n\nfunction classedFalse(names) {\n  return function() {\n    classedRemove(this, names);\n  };\n}\n\nfunction classedFunction(names, value) {\n  return function() {\n    (value.apply(this, arguments) ? classedAdd : classedRemove)(this, names);\n  };\n}\n\nexport default function(name, value) {\n  var names = classArray(name + \"\");\n\n  if (arguments.length < 2) {\n    var list = classList(this.node()), i = -1, n = names.length;\n    while (++i < n) if (!list.contains(names[i])) return false;\n    return true;\n  }\n\n  return this.each((typeof value === \"function\"\n      ? classedFunction : value\n      ? classedTrue\n      : classedFalse)(names, value));\n}\n","function textRemove() {\n  this.textContent = \"\";\n}\n\nfunction textConstant(value) {\n  return function() {\n    this.textContent = value;\n  };\n}\n\nfunction textFunction(value) {\n  return function() {\n    var v = value.apply(this, arguments);\n    this.textContent = v == null ? \"\" : v;\n  };\n}\n\nexport default function(value) {\n  return arguments.length\n      ? this.each(value == null\n          ? textRemove : (typeof value === \"function\"\n          ? textFunction\n          : textConstant)(value))\n      : this.node().textContent;\n}\n","function htmlRemove() {\n  this.innerHTML = \"\";\n}\n\nfunction htmlConstant(value) {\n  return function() {\n    this.innerHTML = value;\n  };\n}\n\nfunction htmlFunction(value) {\n  return function() {\n    var v = value.apply(this, arguments);\n    this.innerHTML = v == null ? \"\" : v;\n  };\n}\n\nexport default function(value) {\n  return arguments.length\n      ? this.each(value == null\n          ? htmlRemove : (typeof value === \"function\"\n          ? htmlFunction\n          : htmlConstant)(value))\n      : this.node().innerHTML;\n}\n","function raise() {\n  if (this.nextSibling) this.parentNode.appendChild(this);\n}\n\nexport default function() {\n  return this.each(raise);\n}\n","function lower() {\n  if (this.previousSibling) this.parentNode.insertBefore(this, this.parentNode.firstChild);\n}\n\nexport default function() {\n  return this.each(lower);\n}\n","import namespace from \"./namespace.js\";\nimport {xhtml} from \"./namespaces.js\";\n\nfunction creatorInherit(name) {\n  return function() {\n    var document = this.ownerDocument,\n        uri = this.namespaceURI;\n    return uri === xhtml && document.documentElement.namespaceURI === xhtml\n        ? document.createElement(name)\n        : document.createElementNS(uri, name);\n  };\n}\n\nfunction creatorFixed(fullname) {\n  return function() {\n    return this.ownerDocument.createElementNS(fullname.space, fullname.local);\n  };\n}\n\nexport default function(name) {\n  var fullname = namespace(name);\n  return (fullname.local\n      ? creatorFixed\n      : creatorInherit)(fullname);\n}\n","import creator from \"../creator.js\";\nimport selector from \"../selector.js\";\n\nfunction constantNull() {\n  return null;\n}\n\nexport default function(name, before) {\n  var create = typeof name === \"function\" ? name : creator(name),\n      select = before == null ? constantNull : typeof before === \"function\" ? before : selector(before);\n  return this.select(function() {\n    return this.insertBefore(create.apply(this, arguments), select.apply(this, arguments) || null);\n  });\n}\n","function remove() {\n  var parent = this.parentNode;\n  if (parent) parent.removeChild(this);\n}\n\nexport default function() {\n  return this.each(remove);\n}\n","function selection_cloneShallow() {\n  var clone = this.cloneNode(false), parent = this.parentNode;\n  return parent ? parent.insertBefore(clone, this.nextSibling) : clone;\n}\n\nfunction selection_cloneDeep() {\n  var clone = this.cloneNode(true), parent = this.parentNode;\n  return parent ? parent.insertBefore(clone, this.nextSibling) : clone;\n}\n\nexport default function(deep) {\n  return this.select(deep ? selection_cloneDeep : selection_cloneShallow);\n}\n","function contextListener(listener) {\n  return function(event) {\n    listener.call(this, event, this.__data__);\n  };\n}\n\nfunction parseTypenames(typenames) {\n  return typenames.trim().split(/^|\\s+/).map(function(t) {\n    var name = \"\", i = t.indexOf(\".\");\n    if (i >= 0) name = t.slice(i + 1), t = t.slice(0, i);\n    return {type: t, name: name};\n  });\n}\n\nfunction onRemove(typename) {\n  return function() {\n    var on = this.__on;\n    if (!on) return;\n    for (var j = 0, i = -1, m = on.length, o; j < m; ++j) {\n      if (o = on[j], (!typename.type || o.type === typename.type) && o.name === typename.name) {\n        this.removeEventListener(o.type, o.listener, o.options);\n      } else {\n        on[++i] = o;\n      }\n    }\n    if (++i) on.length = i;\n    else delete this.__on;\n  };\n}\n\nfunction onAdd(typename, value, options) {\n  return function() {\n    var on = this.__on, o, listener = contextListener(value);\n    if (on) for (var j = 0, m = on.length; j < m; ++j) {\n      if ((o = on[j]).type === typename.type && o.name === typename.name) {\n        this.removeEventListener(o.type, o.listener, o.options);\n        this.addEventListener(o.type, o.listener = listener, o.options = options);\n        o.value = value;\n        return;\n      }\n    }\n    this.addEventListener(typename.type, listener, options);\n    o = {type: typename.type, name: typename.name, value: value, listener: listener, options: options};\n    if (!on) this.__on = [o];\n    else on.push(o);\n  };\n}\n\nexport default function(typename, value, options) {\n  var typenames = parseTypenames(typename + \"\"), i, n = typenames.length, t;\n\n  if (arguments.length < 2) {\n    var on = this.node().__on;\n    if (on) for (var j = 0, m = on.length, o; j < m; ++j) {\n      for (i = 0, o = on[j]; i < n; ++i) {\n        if ((t = typenames[i]).type === o.type && t.name === o.name) {\n          return o.value;\n        }\n      }\n    }\n    return;\n  }\n\n  on = value ? onAdd : onRemove;\n  for (i = 0; i < n; ++i) this.each(on(typenames[i], value, options));\n  return this;\n}\n","import defaultView from \"../window.js\";\n\nfunction dispatchEvent(node, type, params) {\n  var window = defaultView(node),\n      event = window.CustomEvent;\n\n  if (typeof event === \"function\") {\n    event = new event(type, params);\n  } else {\n    event = window.document.createEvent(\"Event\");\n    if (params) event.initEvent(type, params.bubbles, params.cancelable), event.detail = params.detail;\n    else event.initEvent(type, false, false);\n  }\n\n  node.dispatchEvent(event);\n}\n\nfunction dispatchConstant(type, params) {\n  return function() {\n    return dispatchEvent(this, type, params);\n  };\n}\n\nfunction dispatchFunction(type, params) {\n  return function() {\n    return dispatchEvent(this, type, params.apply(this, arguments));\n  };\n}\n\nexport default function(type, params) {\n  return this.each((typeof params === \"function\"\n      ? dispatchFunction\n      : dispatchConstant)(type, params));\n}\n","import selection_select from \"./select.js\";\nimport selection_selectAll from \"./selectAll.js\";\nimport selection_selectChild from \"./selectChild.js\";\nimport selection_selectChildren from \"./selectChildren.js\";\nimport selection_filter from \"./filter.js\";\nimport selection_data from \"./data.js\";\nimport selection_enter from \"./enter.js\";\nimport selection_exit from \"./exit.js\";\nimport selection_join from \"./join.js\";\nimport selection_merge from \"./merge.js\";\nimport selection_order from \"./order.js\";\nimport selection_sort from \"./sort.js\";\nimport selection_call from \"./call.js\";\nimport selection_nodes from \"./nodes.js\";\nimport selection_node from \"./node.js\";\nimport selection_size from \"./size.js\";\nimport selection_empty from \"./empty.js\";\nimport selection_each from \"./each.js\";\nimport selection_attr from \"./attr.js\";\nimport selection_style from \"./style.js\";\nimport selection_property from \"./property.js\";\nimport selection_classed from \"./classed.js\";\nimport selection_text from \"./text.js\";\nimport selection_html from \"./html.js\";\nimport selection_raise from \"./raise.js\";\nimport selection_lower from \"./lower.js\";\nimport selection_append from \"./append.js\";\nimport selection_insert from \"./insert.js\";\nimport selection_remove from \"./remove.js\";\nimport selection_clone from \"./clone.js\";\nimport selection_datum from \"./datum.js\";\nimport selection_on from \"./on.js\";\nimport selection_dispatch from \"./dispatch.js\";\nimport selection_iterator from \"./iterator.js\";\n\nexport var root = [null];\n\nexport function Selection(groups, parents) {\n  this._groups = groups;\n  this._parents = parents;\n}\n\nfunction selection() {\n  return new Selection([[document.documentElement]], root);\n}\n\nfunction selection_selection() {\n  return this;\n}\n\nSelection.prototype = selection.prototype = {\n  constructor: Selection,\n  select: selection_select,\n  selectAll: selection_selectAll,\n  selectChild: selection_selectChild,\n  selectChildren: selection_selectChildren,\n  filter: selection_filter,\n  data: selection_data,\n  enter: selection_enter,\n  exit: selection_exit,\n  join: selection_join,\n  merge: selection_merge,\n  selection: selection_selection,\n  order: selection_order,\n  sort: selection_sort,\n  call: selection_call,\n  nodes: selection_nodes,\n  node: selection_node,\n  size: selection_size,\n  empty: selection_empty,\n  each: selection_each,\n  attr: selection_attr,\n  style: selection_style,\n  property: selection_property,\n  classed: selection_classed,\n  text: selection_text,\n  html: selection_html,\n  raise: selection_raise,\n  lower: selection_lower,\n  append: selection_append,\n  insert: selection_insert,\n  remove: selection_remove,\n  clone: selection_clone,\n  datum: selection_datum,\n  on: selection_on,\n  dispatch: selection_dispatch,\n  [Symbol.iterator]: selection_iterator\n};\n\nexport default selection;\n","import {Selection, root} from \"./selection/index.js\";\n\nexport default function(selector) {\n  return typeof selector === \"string\"\n      ? new Selection([[document.querySelector(selector)]], [document.documentElement])\n      : new Selection([[selector]], root);\n}\n","import sourceEvent from \"./sourceEvent.js\";\n\nexport default function(event, node) {\n  event = sourceEvent(event);\n  if (node === undefined) node = event.currentTarget;\n  if (node) {\n    var svg = node.ownerSVGElement || node;\n    if (svg.createSVGPoint) {\n      var point = svg.createSVGPoint();\n      point.x = event.clientX, point.y = event.clientY;\n      point = point.matrixTransform(node.getScreenCTM().inverse());\n      return [point.x, point.y];\n    }\n    if (node.getBoundingClientRect) {\n      var rect = node.getBoundingClientRect();\n      return [event.clientX - rect.left - node.clientLeft, event.clientY - rect.top - node.clientTop];\n    }\n  }\n  return [event.pageX, event.pageY];\n}\n","export default function(event) {\n  let sourceEvent;\n  while (sourceEvent = event.sourceEvent) event = sourceEvent;\n  return event;\n}\n","import {Selection} from \"./index.js\";\nimport selector from \"../selector.js\";\n\nexport default function(select) {\n  if (typeof select !== \"function\") select = selector(select);\n\n  for (var groups = this._groups, m = groups.length, subgroups = new Array(m), j = 0; j < m; ++j) {\n    for (var group = groups[j], n = group.length, subgroup = subgroups[j] = new Array(n), node, subnode, i = 0; i < n; ++i) {\n      if ((node = group[i]) && (subnode = select.call(node, node.__data__, i, group))) {\n        if (\"__data__\" in node) subnode.__data__ = node.__data__;\n        subgroup[i] = subnode;\n      }\n    }\n  }\n\n  return new Selection(subgroups, this._parents);\n}\n","import {Selection} from \"./index.js\";\nimport array from \"../array.js\";\nimport selectorAll from \"../selectorAll.js\";\n\nfunction arrayAll(select) {\n  return function() {\n    return array(select.apply(this, arguments));\n  };\n}\n\nexport default function(select) {\n  if (typeof select === \"function\") select = arrayAll(select);\n  else select = selectorAll(select);\n\n  for (var groups = this._groups, m = groups.length, subgroups = [], parents = [], j = 0; j < m; ++j) {\n    for (var group = groups[j], n = group.length, node, i = 0; i < n; ++i) {\n      if (node = group[i]) {\n        subgroups.push(select.call(node, node.__data__, i, group));\n        parents.push(node);\n      }\n    }\n  }\n\n  return new Selection(subgroups, parents);\n}\n","import {Selection} from \"./index.js\";\nimport matcher from \"../matcher.js\";\n\nexport default function(match) {\n  if (typeof match !== \"function\") match = matcher(match);\n\n  for (var groups = this._groups, m = groups.length, subgroups = new Array(m), j = 0; j < m; ++j) {\n    for (var group = groups[j], n = group.length, subgroup = subgroups[j] = [], node, i = 0; i < n; ++i) {\n      if ((node = group[i]) && match.call(node, node.__data__, i, group)) {\n        subgroup.push(node);\n      }\n    }\n  }\n\n  return new Selection(subgroups, this._parents);\n}\n","import sparse from \"./sparse.js\";\nimport {Selection} from \"./index.js\";\n\nexport default function() {\n  return new Selection(this._exit || this._groups.map(sparse), this._parents);\n}\n","export default function(onenter, onupdate, onexit) {\n  var enter = this.enter(), update = this, exit = this.exit();\n  if (typeof onenter === \"function\") {\n    enter = onenter(enter);\n    if (enter) enter = enter.selection();\n  } else {\n    enter = enter.append(onenter + \"\");\n  }\n  if (onupdate != null) {\n    update = onupdate(update);\n    if (update) update = update.selection();\n  }\n  if (onexit == null) exit.remove(); else onexit(exit);\n  return enter && update ? enter.merge(update).order() : update;\n}\n","import {Selection} from \"./index.js\";\n\nexport default function(context) {\n  var selection = context.selection ? context.selection() : context;\n\n  for (var groups0 = this._groups, groups1 = selection._groups, m0 = groups0.length, m1 = groups1.length, m = Math.min(m0, m1), merges = new Array(m0), j = 0; j < m; ++j) {\n    for (var group0 = groups0[j], group1 = groups1[j], n = group0.length, merge = merges[j] = new Array(n), node, i = 0; i < n; ++i) {\n      if (node = group0[i] || group1[i]) {\n        merge[i] = node;\n      }\n    }\n  }\n\n  for (; j < m0; ++j) {\n    merges[j] = groups0[j];\n  }\n\n  return new Selection(merges, this._parents);\n}\n","export default function() {\n\n  for (var groups = this._groups, j = -1, m = groups.length; ++j < m;) {\n    for (var group = groups[j], i = group.length - 1, next = group[i], node; --i >= 0;) {\n      if (node = group[i]) {\n        if (next && node.compareDocumentPosition(next) ^ 4) next.parentNode.insertBefore(node, next);\n        next = node;\n      }\n    }\n  }\n\n  return this;\n}\n","export default function() {\n  var callback = arguments[0];\n  arguments[0] = this;\n  callback.apply(null, arguments);\n  return this;\n}\n","export default function() {\n  return Array.from(this);\n}\n","export default function() {\n\n  for (var groups = this._groups, j = 0, m = groups.length; j < m; ++j) {\n    for (var group = groups[j], i = 0, n = group.length; i < n; ++i) {\n      var node = group[i];\n      if (node) return node;\n    }\n  }\n\n  return null;\n}\n","export default function() {\n  let size = 0;\n  for (const node of this) ++size; // eslint-disable-line no-unused-vars\n  return size;\n}\n","export default function() {\n  return !this.node();\n}\n","export default function(callback) {\n\n  for (var groups = this._groups, j = 0, m = groups.length; j < m; ++j) {\n    for (var group = groups[j], i = 0, n = group.length, node; i < n; ++i) {\n      if (node = group[i]) callback.call(node, node.__data__, i, group);\n    }\n  }\n\n  return this;\n}\n","import creator from \"../creator.js\";\n\nexport default function(name) {\n  var create = typeof name === \"function\" ? name : creator(name);\n  return this.select(function() {\n    return this.appendChild(create.apply(this, arguments));\n  });\n}\n","export default function(value) {\n  return arguments.length\n      ? this.property(\"__data__\", value)\n      : this.node().__data__;\n}\n","export default function*() {\n  for (var groups = this._groups, j = 0, m = groups.length; j < m; ++j) {\n    for (var group = groups[j], i = 0, n = group.length, node; i < n; ++i) {\n      if (node = group[i]) yield node;\n    }\n  }\n}\n","var frame = 0, // is an animation frame pending?\n    timeout = 0, // is a timeout pending?\n    interval = 0, // are any timers active?\n    pokeDelay = 1000, // how frequently we check for clock skew\n    taskHead,\n    taskTail,\n    clockLast = 0,\n    clockNow = 0,\n    clockSkew = 0,\n    clock = typeof performance === \"object\" && performance.now ? performance : Date,\n    setFrame = typeof window === \"object\" && window.requestAnimationFrame ? window.requestAnimationFrame.bind(window) : function(f) { setTimeout(f, 17); };\n\nexport function now() {\n  return clockNow || (setFrame(clearNow), clockNow = clock.now() + clockSkew);\n}\n\nfunction clearNow() {\n  clockNow = 0;\n}\n\nexport function Timer() {\n  this._call =\n  this._time =\n  this._next = null;\n}\n\nTimer.prototype = timer.prototype = {\n  constructor: Timer,\n  restart: function(callback, delay, time) {\n    if (typeof callback !== \"function\") throw new TypeError(\"callback is not a function\");\n    time = (time == null ? now() : +time) + (delay == null ? 0 : +delay);\n    if (!this._next && taskTail !== this) {\n      if (taskTail) taskTail._next = this;\n      else taskHead = this;\n      taskTail = this;\n    }\n    this._call = callback;\n    this._time = time;\n    sleep();\n  },\n  stop: function() {\n    if (this._call) {\n      this._call = null;\n      this._time = Infinity;\n      sleep();\n    }\n  }\n};\n\nexport function timer(callback, delay, time) {\n  var t = new Timer;\n  t.restart(callback, delay, time);\n  return t;\n}\n\nexport function timerFlush() {\n  now(); // Get the current time, if not already set.\n  ++frame; // Pretend we’ve set an alarm, if we haven’t already.\n  var t = taskHead, e;\n  while (t) {\n    if ((e = clockNow - t._time) >= 0) t._call.call(undefined, e);\n    t = t._next;\n  }\n  --frame;\n}\n\nfunction wake() {\n  clockNow = (clockLast = clock.now()) + clockSkew;\n  frame = timeout = 0;\n  try {\n    timerFlush();\n  } finally {\n    frame = 0;\n    nap();\n    clockNow = 0;\n  }\n}\n\nfunction poke() {\n  var now = clock.now(), delay = now - clockLast;\n  if (delay > pokeDelay) clockSkew -= delay, clockLast = now;\n}\n\nfunction nap() {\n  var t0, t1 = taskHead, t2, time = Infinity;\n  while (t1) {\n    if (t1._call) {\n      if (time > t1._time) time = t1._time;\n      t0 = t1, t1 = t1._next;\n    } else {\n      t2 = t1._next, t1._next = null;\n      t1 = t0 ? t0._next = t2 : taskHead = t2;\n    }\n  }\n  taskTail = t0;\n  sleep(time);\n}\n\nfunction sleep(time) {\n  if (frame) return; // Soonest alarm already set, or will be.\n  if (timeout) timeout = clearTimeout(timeout);\n  var delay = time - clockNow; // Strictly less than if we recomputed clockNow.\n  if (delay > 24) {\n    if (time < Infinity) timeout = setTimeout(wake, time - clock.now() - clockSkew);\n    if (interval) interval = clearInterval(interval);\n  } else {\n    if (!interval) clockLast = clock.now(), interval = setInterval(poke, pokeDelay);\n    frame = 1, setFrame(wake);\n  }\n}\n","import {Timer} from \"./timer.js\";\n\nexport default function(callback, delay, time) {\n  var t = new Timer;\n  delay = delay == null ? 0 : +delay;\n  t.restart(elapsed => {\n    t.stop();\n    callback(elapsed + delay);\n  }, delay, time);\n  return t;\n}\n","import {dispatch} from \"d3-dispatch\";\nimport {timer, timeout} from \"d3-timer\";\n\nvar emptyOn = dispatch(\"start\", \"end\", \"cancel\", \"interrupt\");\nvar emptyTween = [];\n\nexport var CREATED = 0;\nexport var SCHEDULED = 1;\nexport var STARTING = 2;\nexport var STARTED = 3;\nexport var RUNNING = 4;\nexport var ENDING = 5;\nexport var ENDED = 6;\n\nexport default function(node, name, id, index, group, timing) {\n  var schedules = node.__transition;\n  if (!schedules) node.__transition = {};\n  else if (id in schedules) return;\n  create(node, id, {\n    name: name,\n    index: index, // For context during callback.\n    group: group, // For context during callback.\n    on: emptyOn,\n    tween: emptyTween,\n    time: timing.time,\n    delay: timing.delay,\n    duration: timing.duration,\n    ease: timing.ease,\n    timer: null,\n    state: CREATED\n  });\n}\n\nexport function init(node, id) {\n  var schedule = get(node, id);\n  if (schedule.state > CREATED) throw new Error(\"too late; already scheduled\");\n  return schedule;\n}\n\nexport function set(node, id) {\n  var schedule = get(node, id);\n  if (schedule.state > STARTED) throw new Error(\"too late; already running\");\n  return schedule;\n}\n\nexport function get(node, id) {\n  var schedule = node.__transition;\n  if (!schedule || !(schedule = schedule[id])) throw new Error(\"transition not found\");\n  return schedule;\n}\n\nfunction create(node, id, self) {\n  var schedules = node.__transition,\n      tween;\n\n  // Initialize the self timer when the transition is created.\n  // Note the actual delay is not known until the first callback!\n  schedules[id] = self;\n  self.timer = timer(schedule, 0, self.time);\n\n  function schedule(elapsed) {\n    self.state = SCHEDULED;\n    self.timer.restart(start, self.delay, self.time);\n\n    // If the elapsed delay is less than our first sleep, start immediately.\n    if (self.delay <= elapsed) start(elapsed - self.delay);\n  }\n\n  function start(elapsed) {\n    var i, j, n, o;\n\n    // If the state is not SCHEDULED, then we previously errored on start.\n    if (self.state !== SCHEDULED) return stop();\n\n    for (i in schedules) {\n      o = schedules[i];\n      if (o.name !== self.name) continue;\n\n      // While this element already has a starting transition during this frame,\n      // defer starting an interrupting transition until that transition has a\n      // chance to tick (and possibly end); see d3/d3-transition#54!\n      if (o.state === STARTED) return timeout(start);\n\n      // Interrupt the active transition, if any.\n      if (o.state === RUNNING) {\n        o.state = ENDED;\n        o.timer.stop();\n        o.on.call(\"interrupt\", node, node.__data__, o.index, o.group);\n        delete schedules[i];\n      }\n\n      // Cancel any pre-empted transitions.\n      else if (+i < id) {\n        o.state = ENDED;\n        o.timer.stop();\n        o.on.call(\"cancel\", node, node.__data__, o.index, o.group);\n        delete schedules[i];\n      }\n    }\n\n    // Defer the first tick to end of the current frame; see d3/d3#1576.\n    // Note the transition may be canceled after start and before the first tick!\n    // Note this must be scheduled before the start event; see d3/d3-transition#16!\n    // Assuming this is successful, subsequent callbacks go straight to tick.\n    timeout(function() {\n      if (self.state === STARTED) {\n        self.state = RUNNING;\n        self.timer.restart(tick, self.delay, self.time);\n        tick(elapsed);\n      }\n    });\n\n    // Dispatch the start event.\n    // Note this must be done before the tween are initialized.\n    self.state = STARTING;\n    self.on.call(\"start\", node, node.__data__, self.index, self.group);\n    if (self.state !== STARTING) return; // interrupted\n    self.state = STARTED;\n\n    // Initialize the tween, deleting null tween.\n    tween = new Array(n = self.tween.length);\n    for (i = 0, j = -1; i < n; ++i) {\n      if (o = self.tween[i].value.call(node, node.__data__, self.index, self.group)) {\n        tween[++j] = o;\n      }\n    }\n    tween.length = j + 1;\n  }\n\n  function tick(elapsed) {\n    var t = elapsed < self.duration ? self.ease.call(null, elapsed / self.duration) : (self.timer.restart(stop), self.state = ENDING, 1),\n        i = -1,\n        n = tween.length;\n\n    while (++i < n) {\n      tween[i].call(node, t);\n    }\n\n    // Dispatch the end event.\n    if (self.state === ENDING) {\n      self.on.call(\"end\", node, node.__data__, self.index, self.group);\n      stop();\n    }\n  }\n\n  function stop() {\n    self.state = ENDED;\n    self.timer.stop();\n    delete schedules[id];\n    for (var i in schedules) return; // eslint-disable-line no-unused-vars\n    delete node.__transition;\n  }\n}\n","import {STARTING, ENDING, ENDED} from \"./transition/schedule.js\";\n\nexport default function(node, name) {\n  var schedules = node.__transition,\n      schedule,\n      active,\n      empty = true,\n      i;\n\n  if (!schedules) return;\n\n  name = name == null ? null : name + \"\";\n\n  for (i in schedules) {\n    if ((schedule = schedules[i]).name !== name) { empty = false; continue; }\n    active = schedule.state > STARTING && schedule.state < ENDING;\n    schedule.state = ENDED;\n    schedule.timer.stop();\n    schedule.on.call(active ? \"interrupt\" : \"cancel\", node, node.__data__, schedule.index, schedule.group);\n    delete schedules[i];\n  }\n\n  if (empty) delete node.__transition;\n}\n","var degrees = 180 / Math.PI;\n\nexport var identity = {\n  translateX: 0,\n  translateY: 0,\n  rotate: 0,\n  skewX: 0,\n  scaleX: 1,\n  scaleY: 1\n};\n\nexport default function(a, b, c, d, e, f) {\n  var scaleX, scaleY, skewX;\n  if (scaleX = Math.sqrt(a * a + b * b)) a /= scaleX, b /= scaleX;\n  if (skewX = a * c + b * d) c -= a * skewX, d -= b * skewX;\n  if (scaleY = Math.sqrt(c * c + d * d)) c /= scaleY, d /= scaleY, skewX /= scaleY;\n  if (a * d < b * c) a = -a, b = -b, skewX = -skewX, scaleX = -scaleX;\n  return {\n    translateX: e,\n    translateY: f,\n    rotate: Math.atan2(b, a) * degrees,\n    skewX: Math.atan(skewX) * degrees,\n    scaleX: scaleX,\n    scaleY: scaleY\n  };\n}\n","import decompose, {identity} from \"./decompose.js\";\n\nvar svgNode;\n\n/* eslint-disable no-undef */\nexport function parseCss(value) {\n  const m = new (typeof DOMMatrix === \"function\" ? DOMMatrix : WebKitCSSMatrix)(value + \"\");\n  return m.isIdentity ? identity : decompose(m.a, m.b, m.c, m.d, m.e, m.f);\n}\n\nexport function parseSvg(value) {\n  if (value == null) return identity;\n  if (!svgNode) svgNode = document.createElementNS(\"http://www.w3.org/2000/svg\", \"g\");\n  svgNode.setAttribute(\"transform\", value);\n  if (!(value = svgNode.transform.baseVal.consolidate())) return identity;\n  value = value.matrix;\n  return decompose(value.a, value.b, value.c, value.d, value.e, value.f);\n}\n","import number from \"../number.js\";\nimport {parseCss, parseSvg} from \"./parse.js\";\n\nfunction interpolateTransform(parse, pxComma, pxParen, degParen) {\n\n  function pop(s) {\n    return s.length ? s.pop() + \" \" : \"\";\n  }\n\n  function translate(xa, ya, xb, yb, s, q) {\n    if (xa !== xb || ya !== yb) {\n      var i = s.push(\"translate(\", null, pxComma, null, pxParen);\n      q.push({i: i - 4, x: number(xa, xb)}, {i: i - 2, x: number(ya, yb)});\n    } else if (xb || yb) {\n      s.push(\"translate(\" + xb + pxComma + yb + pxParen);\n    }\n  }\n\n  function rotate(a, b, s, q) {\n    if (a !== b) {\n      if (a - b > 180) b += 360; else if (b - a > 180) a += 360; // shortest path\n      q.push({i: s.push(pop(s) + \"rotate(\", null, degParen) - 2, x: number(a, b)});\n    } else if (b) {\n      s.push(pop(s) + \"rotate(\" + b + degParen);\n    }\n  }\n\n  function skewX(a, b, s, q) {\n    if (a !== b) {\n      q.push({i: s.push(pop(s) + \"skewX(\", null, degParen) - 2, x: number(a, b)});\n    } else if (b) {\n      s.push(pop(s) + \"skewX(\" + b + degParen);\n    }\n  }\n\n  function scale(xa, ya, xb, yb, s, q) {\n    if (xa !== xb || ya !== yb) {\n      var i = s.push(pop(s) + \"scale(\", null, \",\", null, \")\");\n      q.push({i: i - 4, x: number(xa, xb)}, {i: i - 2, x: number(ya, yb)});\n    } else if (xb !== 1 || yb !== 1) {\n      s.push(pop(s) + \"scale(\" + xb + \",\" + yb + \")\");\n    }\n  }\n\n  return function(a, b) {\n    var s = [], // string constants and placeholders\n        q = []; // number interpolators\n    a = parse(a), b = parse(b);\n    translate(a.translateX, a.translateY, b.translateX, b.translateY, s, q);\n    rotate(a.rotate, b.rotate, s, q);\n    skewX(a.skewX, b.skewX, s, q);\n    scale(a.scaleX, a.scaleY, b.scaleX, b.scaleY, s, q);\n    a = b = null; // gc\n    return function(t) {\n      var i = -1, n = q.length, o;\n      while (++i < n) s[(o = q[i]).i] = o.x(t);\n      return s.join(\"\");\n    };\n  };\n}\n\nexport var interpolateTransformCss = interpolateTransform(parseCss, \"px, \", \"px)\", \"deg)\");\nexport var interpolateTransformSvg = interpolateTransform(parseSvg, \", \", \")\", \")\");\n","import {get, set} from \"./schedule.js\";\n\nfunction tweenRemove(id, name) {\n  var tween0, tween1;\n  return function() {\n    var schedule = set(this, id),\n        tween = schedule.tween;\n\n    // If this node shared tween with the previous node,\n    // just assign the updated shared tween and we’re done!\n    // Otherwise, copy-on-write.\n    if (tween !== tween0) {\n      tween1 = tween0 = tween;\n      for (var i = 0, n = tween1.length; i < n; ++i) {\n        if (tween1[i].name === name) {\n          tween1 = tween1.slice();\n          tween1.splice(i, 1);\n          break;\n        }\n      }\n    }\n\n    schedule.tween = tween1;\n  };\n}\n\nfunction tweenFunction(id, name, value) {\n  var tween0, tween1;\n  if (typeof value !== \"function\") throw new Error;\n  return function() {\n    var schedule = set(this, id),\n        tween = schedule.tween;\n\n    // If this node shared tween with the previous node,\n    // just assign the updated shared tween and we’re done!\n    // Otherwise, copy-on-write.\n    if (tween !== tween0) {\n      tween1 = (tween0 = tween).slice();\n      for (var t = {name: name, value: value}, i = 0, n = tween1.length; i < n; ++i) {\n        if (tween1[i].name === name) {\n          tween1[i] = t;\n          break;\n        }\n      }\n      if (i === n) tween1.push(t);\n    }\n\n    schedule.tween = tween1;\n  };\n}\n\nexport default function(name, value) {\n  var id = this._id;\n\n  name += \"\";\n\n  if (arguments.length < 2) {\n    var tween = get(this.node(), id).tween;\n    for (var i = 0, n = tween.length, t; i < n; ++i) {\n      if ((t = tween[i]).name === name) {\n        return t.value;\n      }\n    }\n    return null;\n  }\n\n  return this.each((value == null ? tweenRemove : tweenFunction)(id, name, value));\n}\n\nexport function tweenValue(transition, name, value) {\n  var id = transition._id;\n\n  transition.each(function() {\n    var schedule = set(this, id);\n    (schedule.value || (schedule.value = {}))[name] = value.apply(this, arguments);\n  });\n\n  return function(node) {\n    return get(node, id).value[name];\n  };\n}\n","import {color} from \"d3-color\";\nimport {interpolateNumber, interpolateRgb, interpolateString} from \"d3-interpolate\";\n\nexport default function(a, b) {\n  var c;\n  return (typeof b === \"number\" ? interpolateNumber\n      : b instanceof color ? interpolateRgb\n      : (c = color(b)) ? (b = c, interpolateRgb)\n      : interpolateString)(a, b);\n}\n","import {interpolateTransformSvg as interpolateTransform} from \"d3-interpolate\";\nimport {namespace} from \"d3-selection\";\nimport {tweenValue} from \"./tween.js\";\nimport interpolate from \"./interpolate.js\";\n\nfunction attrRemove(name) {\n  return function() {\n    this.removeAttribute(name);\n  };\n}\n\nfunction attrRemoveNS(fullname) {\n  return function() {\n    this.removeAttributeNS(fullname.space, fullname.local);\n  };\n}\n\nfunction attrConstant(name, interpolate, value1) {\n  var string00,\n      string1 = value1 + \"\",\n      interpolate0;\n  return function() {\n    var string0 = this.getAttribute(name);\n    return string0 === string1 ? null\n        : string0 === string00 ? interpolate0\n        : interpolate0 = interpolate(string00 = string0, value1);\n  };\n}\n\nfunction attrConstantNS(fullname, interpolate, value1) {\n  var string00,\n      string1 = value1 + \"\",\n      interpolate0;\n  return function() {\n    var string0 = this.getAttributeNS(fullname.space, fullname.local);\n    return string0 === string1 ? null\n        : string0 === string00 ? interpolate0\n        : interpolate0 = interpolate(string00 = string0, value1);\n  };\n}\n\nfunction attrFunction(name, interpolate, value) {\n  var string00,\n      string10,\n      interpolate0;\n  return function() {\n    var string0, value1 = value(this), string1;\n    if (value1 == null) return void this.removeAttribute(name);\n    string0 = this.getAttribute(name);\n    string1 = value1 + \"\";\n    return string0 === string1 ? null\n        : string0 === string00 && string1 === string10 ? interpolate0\n        : (string10 = string1, interpolate0 = interpolate(string00 = string0, value1));\n  };\n}\n\nfunction attrFunctionNS(fullname, interpolate, value) {\n  var string00,\n      string10,\n      interpolate0;\n  return function() {\n    var string0, value1 = value(this), string1;\n    if (value1 == null) return void this.removeAttributeNS(fullname.space, fullname.local);\n    string0 = this.getAttributeNS(fullname.space, fullname.local);\n    string1 = value1 + \"\";\n    return string0 === string1 ? null\n        : string0 === string00 && string1 === string10 ? interpolate0\n        : (string10 = string1, interpolate0 = interpolate(string00 = string0, value1));\n  };\n}\n\nexport default function(name, value) {\n  var fullname = namespace(name), i = fullname === \"transform\" ? interpolateTransform : interpolate;\n  return this.attrTween(name, typeof value === \"function\"\n      ? (fullname.local ? attrFunctionNS : attrFunction)(fullname, i, tweenValue(this, \"attr.\" + name, value))\n      : value == null ? (fullname.local ? attrRemoveNS : attrRemove)(fullname)\n      : (fullname.local ? attrConstantNS : attrConstant)(fullname, i, value));\n}\n","import {namespace} from \"d3-selection\";\n\nfunction attrInterpolate(name, i) {\n  return function(t) {\n    this.setAttribute(name, i.call(this, t));\n  };\n}\n\nfunction attrInterpolateNS(fullname, i) {\n  return function(t) {\n    this.setAttributeNS(fullname.space, fullname.local, i.call(this, t));\n  };\n}\n\nfunction attrTweenNS(fullname, value) {\n  var t0, i0;\n  function tween() {\n    var i = value.apply(this, arguments);\n    if (i !== i0) t0 = (i0 = i) && attrInterpolateNS(fullname, i);\n    return t0;\n  }\n  tween._value = value;\n  return tween;\n}\n\nfunction attrTween(name, value) {\n  var t0, i0;\n  function tween() {\n    var i = value.apply(this, arguments);\n    if (i !== i0) t0 = (i0 = i) && attrInterpolate(name, i);\n    return t0;\n  }\n  tween._value = value;\n  return tween;\n}\n\nexport default function(name, value) {\n  var key = \"attr.\" + name;\n  if (arguments.length < 2) return (key = this.tween(key)) && key._value;\n  if (value == null) return this.tween(key, null);\n  if (typeof value !== \"function\") throw new Error;\n  var fullname = namespace(name);\n  return this.tween(key, (fullname.local ? attrTweenNS : attrTween)(fullname, value));\n}\n","import {get, init} from \"./schedule.js\";\n\nfunction delayFunction(id, value) {\n  return function() {\n    init(this, id).delay = +value.apply(this, arguments);\n  };\n}\n\nfunction delayConstant(id, value) {\n  return value = +value, function() {\n    init(this, id).delay = value;\n  };\n}\n\nexport default function(value) {\n  var id = this._id;\n\n  return arguments.length\n      ? this.each((typeof value === \"function\"\n          ? delayFunction\n          : delayConstant)(id, value))\n      : get(this.node(), id).delay;\n}\n","import {get, set} from \"./schedule.js\";\n\nfunction durationFunction(id, value) {\n  return function() {\n    set(this, id).duration = +value.apply(this, arguments);\n  };\n}\n\nfunction durationConstant(id, value) {\n  return value = +value, function() {\n    set(this, id).duration = value;\n  };\n}\n\nexport default function(value) {\n  var id = this._id;\n\n  return arguments.length\n      ? this.each((typeof value === \"function\"\n          ? durationFunction\n          : durationConstant)(id, value))\n      : get(this.node(), id).duration;\n}\n","import {get, set} from \"./schedule.js\";\n\nfunction easeConstant(id, value) {\n  if (typeof value !== \"function\") throw new Error;\n  return function() {\n    set(this, id).ease = value;\n  };\n}\n\nexport default function(value) {\n  var id = this._id;\n\n  return arguments.length\n      ? this.each(easeConstant(id, value))\n      : get(this.node(), id).ease;\n}\n","import {get, set, init} from \"./schedule.js\";\n\nfunction start(name) {\n  return (name + \"\").trim().split(/^|\\s+/).every(function(t) {\n    var i = t.indexOf(\".\");\n    if (i >= 0) t = t.slice(0, i);\n    return !t || t === \"start\";\n  });\n}\n\nfunction onFunction(id, name, listener) {\n  var on0, on1, sit = start(name) ? init : set;\n  return function() {\n    var schedule = sit(this, id),\n        on = schedule.on;\n\n    // If this node shared a dispatch with the previous node,\n    // just assign the updated shared dispatch and we’re done!\n    // Otherwise, copy-on-write.\n    if (on !== on0) (on1 = (on0 = on).copy()).on(name, listener);\n\n    schedule.on = on1;\n  };\n}\n\nexport default function(name, listener) {\n  var id = this._id;\n\n  return arguments.length < 2\n      ? get(this.node(), id).on.on(name)\n      : this.each(onFunction(id, name, listener));\n}\n","import {selection} from \"d3-selection\";\n\nvar Selection = selection.prototype.constructor;\n\nexport default function() {\n  return new Selection(this._groups, this._parents);\n}\n","import {interpolateTransformCss as interpolateTransform} from \"d3-interpolate\";\nimport {style} from \"d3-selection\";\nimport {set} from \"./schedule.js\";\nimport {tweenValue} from \"./tween.js\";\nimport interpolate from \"./interpolate.js\";\n\nfunction styleNull(name, interpolate) {\n  var string00,\n      string10,\n      interpolate0;\n  return function() {\n    var string0 = style(this, name),\n        string1 = (this.style.removeProperty(name), style(this, name));\n    return string0 === string1 ? null\n        : string0 === string00 && string1 === string10 ? interpolate0\n        : interpolate0 = interpolate(string00 = string0, string10 = string1);\n  };\n}\n\nfunction styleRemove(name) {\n  return function() {\n    this.style.removeProperty(name);\n  };\n}\n\nfunction styleConstant(name, interpolate, value1) {\n  var string00,\n      string1 = value1 + \"\",\n      interpolate0;\n  return function() {\n    var string0 = style(this, name);\n    return string0 === string1 ? null\n        : string0 === string00 ? interpolate0\n        : interpolate0 = interpolate(string00 = string0, value1);\n  };\n}\n\nfunction styleFunction(name, interpolate, value) {\n  var string00,\n      string10,\n      interpolate0;\n  return function() {\n    var string0 = style(this, name),\n        value1 = value(this),\n        string1 = value1 + \"\";\n    if (value1 == null) string1 = value1 = (this.style.removeProperty(name), style(this, name));\n    return string0 === string1 ? null\n        : string0 === string00 && string1 === string10 ? interpolate0\n        : (string10 = string1, interpolate0 = interpolate(string00 = string0, value1));\n  };\n}\n\nfunction styleMaybeRemove(id, name) {\n  var on0, on1, listener0, key = \"style.\" + name, event = \"end.\" + key, remove;\n  return function() {\n    var schedule = set(this, id),\n        on = schedule.on,\n        listener = schedule.value[key] == null ? remove || (remove = styleRemove(name)) : undefined;\n\n    // If this node shared a dispatch with the previous node,\n    // just assign the updated shared dispatch and we’re done!\n    // Otherwise, copy-on-write.\n    if (on !== on0 || listener0 !== listener) (on1 = (on0 = on).copy()).on(event, listener0 = listener);\n\n    schedule.on = on1;\n  };\n}\n\nexport default function(name, value, priority) {\n  var i = (name += \"\") === \"transform\" ? interpolateTransform : interpolate;\n  return value == null ? this\n      .styleTween(name, styleNull(name, i))\n      .on(\"end.style.\" + name, styleRemove(name))\n    : typeof value === \"function\" ? this\n      .styleTween(name, styleFunction(name, i, tweenValue(this, \"style.\" + name, value)))\n      .each(styleMaybeRemove(this._id, name))\n    : this\n      .styleTween(name, styleConstant(name, i, value), priority)\n      .on(\"end.style.\" + name, null);\n}\n","function styleInterpolate(name, i, priority) {\n  return function(t) {\n    this.style.setProperty(name, i.call(this, t), priority);\n  };\n}\n\nfunction styleTween(name, value, priority) {\n  var t, i0;\n  function tween() {\n    var i = value.apply(this, arguments);\n    if (i !== i0) t = (i0 = i) && styleInterpolate(name, i, priority);\n    return t;\n  }\n  tween._value = value;\n  return tween;\n}\n\nexport default function(name, value, priority) {\n  var key = \"style.\" + (name += \"\");\n  if (arguments.length < 2) return (key = this.tween(key)) && key._value;\n  if (value == null) return this.tween(key, null);\n  if (typeof value !== \"function\") throw new Error;\n  return this.tween(key, styleTween(name, value, priority == null ? \"\" : priority));\n}\n","function textInterpolate(i) {\n  return function(t) {\n    this.textContent = i.call(this, t);\n  };\n}\n\nfunction textTween(value) {\n  var t0, i0;\n  function tween() {\n    var i = value.apply(this, arguments);\n    if (i !== i0) t0 = (i0 = i) && textInterpolate(i);\n    return t0;\n  }\n  tween._value = value;\n  return tween;\n}\n\nexport default function(value) {\n  var key = \"text\";\n  if (arguments.length < 1) return (key = this.tween(key)) && key._value;\n  if (value == null) return this.tween(key, null);\n  if (typeof value !== \"function\") throw new Error;\n  return this.tween(key, textTween(value));\n}\n","import {selection} from \"d3-selection\";\nimport transition_attr from \"./attr.js\";\nimport transition_attrTween from \"./attrTween.js\";\nimport transition_delay from \"./delay.js\";\nimport transition_duration from \"./duration.js\";\nimport transition_ease from \"./ease.js\";\nimport transition_easeVarying from \"./easeVarying.js\";\nimport transition_filter from \"./filter.js\";\nimport transition_merge from \"./merge.js\";\nimport transition_on from \"./on.js\";\nimport transition_remove from \"./remove.js\";\nimport transition_select from \"./select.js\";\nimport transition_selectAll from \"./selectAll.js\";\nimport transition_selection from \"./selection.js\";\nimport transition_style from \"./style.js\";\nimport transition_styleTween from \"./styleTween.js\";\nimport transition_text from \"./text.js\";\nimport transition_textTween from \"./textTween.js\";\nimport transition_transition from \"./transition.js\";\nimport transition_tween from \"./tween.js\";\nimport transition_end from \"./end.js\";\n\nvar id = 0;\n\nexport function Transition(groups, parents, name, id) {\n  this._groups = groups;\n  this._parents = parents;\n  this._name = name;\n  this._id = id;\n}\n\nexport default function transition(name) {\n  return selection().transition(name);\n}\n\nexport function newId() {\n  return ++id;\n}\n\nvar selection_prototype = selection.prototype;\n\nTransition.prototype = transition.prototype = {\n  constructor: Transition,\n  select: transition_select,\n  selectAll: transition_selectAll,\n  selectChild: selection_prototype.selectChild,\n  selectChildren: selection_prototype.selectChildren,\n  filter: transition_filter,\n  merge: transition_merge,\n  selection: transition_selection,\n  transition: transition_transition,\n  call: selection_prototype.call,\n  nodes: selection_prototype.nodes,\n  node: selection_prototype.node,\n  size: selection_prototype.size,\n  empty: selection_prototype.empty,\n  each: selection_prototype.each,\n  on: transition_on,\n  attr: transition_attr,\n  attrTween: transition_attrTween,\n  style: transition_style,\n  styleTween: transition_styleTween,\n  text: transition_text,\n  textTween: transition_textTween,\n  remove: transition_remove,\n  tween: transition_tween,\n  delay: transition_delay,\n  duration: transition_duration,\n  ease: transition_ease,\n  easeVarying: transition_easeVarying,\n  end: transition_end,\n  [Symbol.iterator]: selection_prototype[Symbol.iterator]\n};\n","import {selector} from \"d3-selection\";\nimport {Transition} from \"./index.js\";\nimport schedule, {get} from \"./schedule.js\";\n\nexport default function(select) {\n  var name = this._name,\n      id = this._id;\n\n  if (typeof select !== \"function\") select = selector(select);\n\n  for (var groups = this._groups, m = groups.length, subgroups = new Array(m), j = 0; j < m; ++j) {\n    for (var group = groups[j], n = group.length, subgroup = subgroups[j] = new Array(n), node, subnode, i = 0; i < n; ++i) {\n      if ((node = group[i]) && (subnode = select.call(node, node.__data__, i, group))) {\n        if (\"__data__\" in node) subnode.__data__ = node.__data__;\n        subgroup[i] = subnode;\n        schedule(subgroup[i], name, id, i, subgroup, get(node, id));\n      }\n    }\n  }\n\n  return new Transition(subgroups, this._parents, name, id);\n}\n","import {selectorAll} from \"d3-selection\";\nimport {Transition} from \"./index.js\";\nimport schedule, {get} from \"./schedule.js\";\n\nexport default function(select) {\n  var name = this._name,\n      id = this._id;\n\n  if (typeof select !== \"function\") select = selectorAll(select);\n\n  for (var groups = this._groups, m = groups.length, subgroups = [], parents = [], j = 0; j < m; ++j) {\n    for (var group = groups[j], n = group.length, node, i = 0; i < n; ++i) {\n      if (node = group[i]) {\n        for (var children = select.call(node, node.__data__, i, group), child, inherit = get(node, id), k = 0, l = children.length; k < l; ++k) {\n          if (child = children[k]) {\n            schedule(child, name, id, k, children, inherit);\n          }\n        }\n        subgroups.push(children);\n        parents.push(node);\n      }\n    }\n  }\n\n  return new Transition(subgroups, parents, name, id);\n}\n","import {matcher} from \"d3-selection\";\nimport {Transition} from \"./index.js\";\n\nexport default function(match) {\n  if (typeof match !== \"function\") match = matcher(match);\n\n  for (var groups = this._groups, m = groups.length, subgroups = new Array(m), j = 0; j < m; ++j) {\n    for (var group = groups[j], n = group.length, subgroup = subgroups[j] = [], node, i = 0; i < n; ++i) {\n      if ((node = group[i]) && match.call(node, node.__data__, i, group)) {\n        subgroup.push(node);\n      }\n    }\n  }\n\n  return new Transition(subgroups, this._parents, this._name, this._id);\n}\n","import {Transition} from \"./index.js\";\n\nexport default function(transition) {\n  if (transition._id !== this._id) throw new Error;\n\n  for (var groups0 = this._groups, groups1 = transition._groups, m0 = groups0.length, m1 = groups1.length, m = Math.min(m0, m1), merges = new Array(m0), j = 0; j < m; ++j) {\n    for (var group0 = groups0[j], group1 = groups1[j], n = group0.length, merge = merges[j] = new Array(n), node, i = 0; i < n; ++i) {\n      if (node = group0[i] || group1[i]) {\n        merge[i] = node;\n      }\n    }\n  }\n\n  for (; j < m0; ++j) {\n    merges[j] = groups0[j];\n  }\n\n  return new Transition(merges, this._parents, this._name, this._id);\n}\n","import {Transition, newId} from \"./index.js\";\nimport schedule, {get} from \"./schedule.js\";\n\nexport default function() {\n  var name = this._name,\n      id0 = this._id,\n      id1 = newId();\n\n  for (var groups = this._groups, m = groups.length, j = 0; j < m; ++j) {\n    for (var group = groups[j], n = group.length, node, i = 0; i < n; ++i) {\n      if (node = group[i]) {\n        var inherit = get(node, id0);\n        schedule(node, name, id1, i, group, {\n          time: inherit.time + inherit.delay + inherit.duration,\n          delay: 0,\n          duration: inherit.duration,\n          ease: inherit.ease\n        });\n      }\n    }\n  }\n\n  return new Transition(groups, this._parents, name, id1);\n}\n","import {tweenValue} from \"./tween.js\";\n\nfunction textConstant(value) {\n  return function() {\n    this.textContent = value;\n  };\n}\n\nfunction textFunction(value) {\n  return function() {\n    var value1 = value(this);\n    this.textContent = value1 == null ? \"\" : value1;\n  };\n}\n\nexport default function(value) {\n  return this.tween(\"text\", typeof value === \"function\"\n      ? textFunction(tweenValue(this, \"text\", value))\n      : textConstant(value == null ? \"\" : value + \"\"));\n}\n","function removeFunction(id) {\n  return function() {\n    var parent = this.parentNode;\n    for (var i in this.__transition) if (+i !== id) return;\n    if (parent) parent.removeChild(this);\n  };\n}\n\nexport default function() {\n  return this.on(\"end.remove\", removeFunction(this._id));\n}\n","import {set} from \"./schedule.js\";\n\nfunction easeVarying(id, value) {\n  return function() {\n    var v = value.apply(this, arguments);\n    if (typeof v !== \"function\") throw new Error;\n    set(this, id).ease = v;\n  };\n}\n\nexport default function(value) {\n  if (typeof value !== \"function\") throw new Error;\n  return this.each(easeVarying(this._id, value));\n}\n","import {set} from \"./schedule.js\";\n\nexport default function() {\n  var on0, on1, that = this, id = that._id, size = that.size();\n  return new Promise(function(resolve, reject) {\n    var cancel = {value: reject},\n        end = {value: function() { if (--size === 0) resolve(); }};\n\n    that.each(function() {\n      var schedule = set(this, id),\n          on = schedule.on;\n\n      // If this node shared a dispatch with the previous node,\n      // just assign the updated shared dispatch and we’re done!\n      // Otherwise, copy-on-write.\n      if (on !== on0) {\n        on1 = (on0 = on).copy();\n        on1._.cancel.push(cancel);\n        on1._.interrupt.push(cancel);\n        on1._.end.push(end);\n      }\n\n      schedule.on = on1;\n    });\n\n    // The selection was empty, resolve end immediately\n    if (size === 0) resolve();\n  });\n}\n","import {Transition, newId} from \"../transition/index.js\";\nimport schedule from \"../transition/schedule.js\";\nimport {easeCubicInOut} from \"d3-ease\";\nimport {now} from \"d3-timer\";\n\nvar defaultTiming = {\n  time: null, // Set on use.\n  delay: 0,\n  duration: 250,\n  ease: easeCubicInOut\n};\n\nfunction inherit(node, id) {\n  var timing;\n  while (!(timing = node.__transition) || !(timing = timing[id])) {\n    if (!(node = node.parentNode)) {\n      throw new Error(`transition ${id} not found`);\n    }\n  }\n  return timing;\n}\n\nexport default function(name) {\n  var id,\n      timing;\n\n  if (name instanceof Transition) {\n    id = name._id, name = name._name;\n  } else {\n    id = newId(), (timing = defaultTiming).time = now(), name = name == null ? null : name + \"\";\n  }\n\n  for (var groups = this._groups, m = groups.length, j = 0; j < m; ++j) {\n    for (var group = groups[j], n = group.length, node, i = 0; i < n; ++i) {\n      if (node = group[i]) {\n        schedule(node, name, id, i, group, timing || inherit(node, id));\n      }\n    }\n  }\n\n  return new Transition(groups, this._parents, name, id);\n}\n","export function cubicIn(t) {\n  return t * t * t;\n}\n\nexport function cubicOut(t) {\n  return --t * t * t + 1;\n}\n\nexport function cubicInOut(t) {\n  return ((t *= 2) <= 1 ? t * t * t : (t -= 2) * t * t + 2) / 2;\n}\n","import {selection} from \"d3-selection\";\nimport selection_interrupt from \"./interrupt.js\";\nimport selection_transition from \"./transition.js\";\n\nselection.prototype.interrupt = selection_interrupt;\nselection.prototype.transition = selection_transition;\n","import interrupt from \"../interrupt.js\";\n\nexport default function(name) {\n  return this.each(function() {\n    interrupt(this, name);\n  });\n}\n","export default x => () => x;\n","export default function BrushEvent(type, {\n  sourceEvent,\n  target,\n  selection,\n  mode,\n  dispatch\n}) {\n  Object.defineProperties(this, {\n    type: {value: type, enumerable: true, configurable: true},\n    sourceEvent: {value: sourceEvent, enumerable: true, configurable: true},\n    target: {value: target, enumerable: true, configurable: true},\n    selection: {value: selection, enumerable: true, configurable: true},\n    mode: {value: mode, enumerable: true, configurable: true},\n    _: {value: dispatch}\n  });\n}\n","export function nopropagation(event) {\n  event.stopImmediatePropagation();\n}\n\nexport default function(event) {\n  event.preventDefault();\n  event.stopImmediatePropagation();\n}\n","import {dispatch} from \"d3-dispatch\";\nimport {dragDisable, dragEnable} from \"d3-drag\";\nimport {interpolate} from \"d3-interpolate\";\nimport {pointer, select} from \"d3-selection\";\nimport {interrupt} from \"d3-transition\";\nimport constant from \"./constant.js\";\nimport BrushEvent from \"./event.js\";\nimport noevent, {nopropagation} from \"./noevent.js\";\n\nvar MODE_DRAG = {name: \"drag\"},\n    MODE_SPACE = {name: \"space\"},\n    MODE_HANDLE = {name: \"handle\"},\n    MODE_CENTER = {name: \"center\"};\n\nconst {abs, max, min} = Math;\n\nfunction number1(e) {\n  return [+e[0], +e[1]];\n}\n\nfunction number2(e) {\n  return [number1(e[0]), number1(e[1])];\n}\n\nvar X = {\n  name: \"x\",\n  handles: [\"w\", \"e\"].map(type),\n  input: function(x, e) { return x == null ? null : [[+x[0], e[0][1]], [+x[1], e[1][1]]]; },\n  output: function(xy) { return xy && [xy[0][0], xy[1][0]]; }\n};\n\nvar Y = {\n  name: \"y\",\n  handles: [\"n\", \"s\"].map(type),\n  input: function(y, e) { return y == null ? null : [[e[0][0], +y[0]], [e[1][0], +y[1]]]; },\n  output: function(xy) { return xy && [xy[0][1], xy[1][1]]; }\n};\n\nvar XY = {\n  name: \"xy\",\n  handles: [\"n\", \"w\", \"e\", \"s\", \"nw\", \"ne\", \"sw\", \"se\"].map(type),\n  input: function(xy) { return xy == null ? null : number2(xy); },\n  output: function(xy) { return xy; }\n};\n\nvar cursors = {\n  overlay: \"crosshair\",\n  selection: \"move\",\n  n: \"ns-resize\",\n  e: \"ew-resize\",\n  s: \"ns-resize\",\n  w: \"ew-resize\",\n  nw: \"nwse-resize\",\n  ne: \"nesw-resize\",\n  se: \"nwse-resize\",\n  sw: \"nesw-resize\"\n};\n\nvar flipX = {\n  e: \"w\",\n  w: \"e\",\n  nw: \"ne\",\n  ne: \"nw\",\n  se: \"sw\",\n  sw: \"se\"\n};\n\nvar flipY = {\n  n: \"s\",\n  s: \"n\",\n  nw: \"sw\",\n  ne: \"se\",\n  se: \"ne\",\n  sw: \"nw\"\n};\n\nvar signsX = {\n  overlay: +1,\n  selection: +1,\n  n: null,\n  e: +1,\n  s: null,\n  w: -1,\n  nw: -1,\n  ne: +1,\n  se: +1,\n  sw: -1\n};\n\nvar signsY = {\n  overlay: +1,\n  selection: +1,\n  n: -1,\n  e: null,\n  s: +1,\n  w: null,\n  nw: -1,\n  ne: -1,\n  se: +1,\n  sw: +1\n};\n\nfunction type(t) {\n  return {type: t};\n}\n\n// Ignore right-click, since that should open the context menu.\nfunction defaultFilter(event) {\n  return !event.ctrlKey && !event.button;\n}\n\nfunction defaultExtent() {\n  var svg = this.ownerSVGElement || this;\n  if (svg.hasAttribute(\"viewBox\")) {\n    svg = svg.viewBox.baseVal;\n    return [[svg.x, svg.y], [svg.x + svg.width, svg.y + svg.height]];\n  }\n  return [[0, 0], [svg.width.baseVal.value, svg.height.baseVal.value]];\n}\n\nfunction defaultTouchable() {\n  return navigator.maxTouchPoints || (\"ontouchstart\" in this);\n}\n\n// Like d3.local, but with the name “__brush” rather than auto-generated.\nfunction local(node) {\n  while (!node.__brush) if (!(node = node.parentNode)) return;\n  return node.__brush;\n}\n\nfunction empty(extent) {\n  return extent[0][0] === extent[1][0]\n      || extent[0][1] === extent[1][1];\n}\n\nexport function brushSelection(node) {\n  var state = node.__brush;\n  return state ? state.dim.output(state.selection) : null;\n}\n\nexport function brushX() {\n  return brush(X);\n}\n\nexport function brushY() {\n  return brush(Y);\n}\n\nexport default function() {\n  return brush(XY);\n}\n\nfunction brush(dim) {\n  var extent = defaultExtent,\n      filter = defaultFilter,\n      touchable = defaultTouchable,\n      keys = true,\n      listeners = dispatch(\"start\", \"brush\", \"end\"),\n      handleSize = 6,\n      touchending;\n\n  function brush(group) {\n    var overlay = group\n        .property(\"__brush\", initialize)\n      .selectAll(\".overlay\")\n      .data([type(\"overlay\")]);\n\n    overlay.enter().append(\"rect\")\n        .attr(\"class\", \"overlay\")\n        .attr(\"pointer-events\", \"all\")\n        .attr(\"cursor\", cursors.overlay)\n      .merge(overlay)\n        .each(function() {\n          var extent = local(this).extent;\n          select(this)\n              .attr(\"x\", extent[0][0])\n              .attr(\"y\", extent[0][1])\n              .attr(\"width\", extent[1][0] - extent[0][0])\n              .attr(\"height\", extent[1][1] - extent[0][1]);\n        });\n\n    group.selectAll(\".selection\")\n      .data([type(\"selection\")])\n      .enter().append(\"rect\")\n        .attr(\"class\", \"selection\")\n        .attr(\"cursor\", cursors.selection)\n        .attr(\"fill\", \"#777\")\n        .attr(\"fill-opacity\", 0.3)\n        .attr(\"stroke\", \"#fff\")\n        .attr(\"shape-rendering\", \"crispEdges\");\n\n    var handle = group.selectAll(\".handle\")\n      .data(dim.handles, function(d) { return d.type; });\n\n    handle.exit().remove();\n\n    handle.enter().append(\"rect\")\n        .attr(\"class\", function(d) { return \"handle handle--\" + d.type; })\n        .attr(\"cursor\", function(d) { return cursors[d.type]; });\n\n    group\n        .each(redraw)\n        .attr(\"fill\", \"none\")\n        .attr(\"pointer-events\", \"all\")\n        .on(\"mousedown.brush\", started)\n      .filter(touchable)\n        .on(\"touchstart.brush\", started)\n        .on(\"touchmove.brush\", touchmoved)\n        .on(\"touchend.brush touchcancel.brush\", touchended)\n        .style(\"touch-action\", \"none\")\n        .style(\"-webkit-tap-highlight-color\", \"rgba(0,0,0,0)\");\n  }\n\n  brush.move = function(group, selection, event) {\n    if (group.tween) {\n      group\n          .on(\"start.brush\", function(event) { emitter(this, arguments).beforestart().start(event); })\n          .on(\"interrupt.brush end.brush\", function(event) { emitter(this, arguments).end(event); })\n          .tween(\"brush\", function() {\n            var that = this,\n                state = that.__brush,\n                emit = emitter(that, arguments),\n                selection0 = state.selection,\n                selection1 = dim.input(typeof selection === \"function\" ? selection.apply(this, arguments) : selection, state.extent),\n                i = interpolate(selection0, selection1);\n\n            function tween(t) {\n              state.selection = t === 1 && selection1 === null ? null : i(t);\n              redraw.call(that);\n              emit.brush();\n            }\n\n            return selection0 !== null && selection1 !== null ? tween : tween(1);\n          });\n    } else {\n      group\n          .each(function() {\n            var that = this,\n                args = arguments,\n                state = that.__brush,\n                selection1 = dim.input(typeof selection === \"function\" ? selection.apply(that, args) : selection, state.extent),\n                emit = emitter(that, args).beforestart();\n\n            interrupt(that);\n            state.selection = selection1 === null ? null : selection1;\n            redraw.call(that);\n            emit.start(event).brush(event).end(event);\n          });\n    }\n  };\n\n  brush.clear = function(group, event) {\n    brush.move(group, null, event);\n  };\n\n  function redraw() {\n    var group = select(this),\n        selection = local(this).selection;\n\n    if (selection) {\n      group.selectAll(\".selection\")\n          .style(\"display\", null)\n          .attr(\"x\", selection[0][0])\n          .attr(\"y\", selection[0][1])\n          .attr(\"width\", selection[1][0] - selection[0][0])\n          .attr(\"height\", selection[1][1] - selection[0][1]);\n\n      group.selectAll(\".handle\")\n          .style(\"display\", null)\n          .attr(\"x\", function(d) { return d.type[d.type.length - 1] === \"e\" ? selection[1][0] - handleSize / 2 : selection[0][0] - handleSize / 2; })\n          .attr(\"y\", function(d) { return d.type[0] === \"s\" ? selection[1][1] - handleSize / 2 : selection[0][1] - handleSize / 2; })\n          .attr(\"width\", function(d) { return d.type === \"n\" || d.type === \"s\" ? selection[1][0] - selection[0][0] + handleSize : handleSize; })\n          .attr(\"height\", function(d) { return d.type === \"e\" || d.type === \"w\" ? selection[1][1] - selection[0][1] + handleSize : handleSize; });\n    }\n\n    else {\n      group.selectAll(\".selection,.handle\")\n          .style(\"display\", \"none\")\n          .attr(\"x\", null)\n          .attr(\"y\", null)\n          .attr(\"width\", null)\n          .attr(\"height\", null);\n    }\n  }\n\n  function emitter(that, args, clean) {\n    var emit = that.__brush.emitter;\n    return emit && (!clean || !emit.clean) ? emit : new Emitter(that, args, clean);\n  }\n\n  function Emitter(that, args, clean) {\n    this.that = that;\n    this.args = args;\n    this.state = that.__brush;\n    this.active = 0;\n    this.clean = clean;\n  }\n\n  Emitter.prototype = {\n    beforestart: function() {\n      if (++this.active === 1) this.state.emitter = this, this.starting = true;\n      return this;\n    },\n    start: function(event, mode) {\n      if (this.starting) this.starting = false, this.emit(\"start\", event, mode);\n      else this.emit(\"brush\", event);\n      return this;\n    },\n    brush: function(event, mode) {\n      this.emit(\"brush\", event, mode);\n      return this;\n    },\n    end: function(event, mode) {\n      if (--this.active === 0) delete this.state.emitter, this.emit(\"end\", event, mode);\n      return this;\n    },\n    emit: function(type, event, mode) {\n      var d = select(this.that).datum();\n      listeners.call(\n        type,\n        this.that,\n        new BrushEvent(type, {\n          sourceEvent: event,\n          target: brush,\n          selection: dim.output(this.state.selection),\n          mode,\n          dispatch: listeners\n        }),\n        d\n      );\n    }\n  };\n\n  function started(event) {\n    if (touchending && !event.touches) return;\n    if (!filter.apply(this, arguments)) return;\n\n    var that = this,\n        type = event.target.__data__.type,\n        mode = (keys && event.metaKey ? type = \"overlay\" : type) === \"selection\" ? MODE_DRAG : (keys && event.altKey ? MODE_CENTER : MODE_HANDLE),\n        signX = dim === Y ? null : signsX[type],\n        signY = dim === X ? null : signsY[type],\n        state = local(that),\n        extent = state.extent,\n        selection = state.selection,\n        W = extent[0][0], w0, w1,\n        N = extent[0][1], n0, n1,\n        E = extent[1][0], e0, e1,\n        S = extent[1][1], s0, s1,\n        dx = 0,\n        dy = 0,\n        moving,\n        shifting = signX && signY && keys && event.shiftKey,\n        lockX,\n        lockY,\n        points = Array.from(event.touches || [event], t => {\n          const i = t.identifier;\n          t = pointer(t, that);\n          t.point0 = t.slice();\n          t.identifier = i;\n          return t;\n        });\n\n    interrupt(that);\n    var emit = emitter(that, arguments, true).beforestart();\n\n    if (type === \"overlay\") {\n      if (selection) moving = true;\n      const pts = [points[0], points[1] || points[0]];\n      state.selection = selection = [[\n          w0 = dim === Y ? W : min(pts[0][0], pts[1][0]),\n          n0 = dim === X ? N : min(pts[0][1], pts[1][1])\n        ], [\n          e0 = dim === Y ? E : max(pts[0][0], pts[1][0]),\n          s0 = dim === X ? S : max(pts[0][1], pts[1][1])\n        ]];\n      if (points.length > 1) move(event);\n    } else {\n      w0 = selection[0][0];\n      n0 = selection[0][1];\n      e0 = selection[1][0];\n      s0 = selection[1][1];\n    }\n\n    w1 = w0;\n    n1 = n0;\n    e1 = e0;\n    s1 = s0;\n\n    var group = select(that)\n        .attr(\"pointer-events\", \"none\");\n\n    var overlay = group.selectAll(\".overlay\")\n        .attr(\"cursor\", cursors[type]);\n\n    if (event.touches) {\n      emit.moved = moved;\n      emit.ended = ended;\n    } else {\n      var view = select(event.view)\n          .on(\"mousemove.brush\", moved, true)\n          .on(\"mouseup.brush\", ended, true);\n      if (keys) view\n          .on(\"keydown.brush\", keydowned, true)\n          .on(\"keyup.brush\", keyupped, true)\n\n      dragDisable(event.view);\n    }\n\n    redraw.call(that);\n    emit.start(event, mode.name);\n\n    function moved(event) {\n      for (const p of event.changedTouches || [event]) {\n        for (const d of points)\n          if (d.identifier === p.identifier) d.cur = pointer(p, that);\n      }\n      if (shifting && !lockX && !lockY && points.length === 1) {\n        const point = points[0];\n        if (abs(point.cur[0] - point[0]) > abs(point.cur[1] - point[1]))\n          lockY = true;\n        else\n          lockX = true;\n      }\n      for (const point of points)\n        if (point.cur) point[0] = point.cur[0], point[1] = point.cur[1];\n      moving = true;\n      noevent(event);\n      move(event);\n    }\n\n    function move(event) {\n      const point = points[0], point0 = point.point0;\n      var t;\n\n      dx = point[0] - point0[0];\n      dy = point[1] - point0[1];\n\n      switch (mode) {\n        case MODE_SPACE:\n        case MODE_DRAG: {\n          if (signX) dx = max(W - w0, min(E - e0, dx)), w1 = w0 + dx, e1 = e0 + dx;\n          if (signY) dy = max(N - n0, min(S - s0, dy)), n1 = n0 + dy, s1 = s0 + dy;\n          break;\n        }\n        case MODE_HANDLE: {\n          if (points[1]) {\n            if (signX) w1 = max(W, min(E, points[0][0])), e1 = max(W, min(E, points[1][0])), signX = 1;\n            if (signY) n1 = max(N, min(S, points[0][1])), s1 = max(N, min(S, points[1][1])), signY = 1;\n          } else {\n            if (signX < 0) dx = max(W - w0, min(E - w0, dx)), w1 = w0 + dx, e1 = e0;\n            else if (signX > 0) dx = max(W - e0, min(E - e0, dx)), w1 = w0, e1 = e0 + dx;\n            if (signY < 0) dy = max(N - n0, min(S - n0, dy)), n1 = n0 + dy, s1 = s0;\n            else if (signY > 0) dy = max(N - s0, min(S - s0, dy)), n1 = n0, s1 = s0 + dy;\n          }\n          break;\n        }\n        case MODE_CENTER: {\n          if (signX) w1 = max(W, min(E, w0 - dx * signX)), e1 = max(W, min(E, e0 + dx * signX));\n          if (signY) n1 = max(N, min(S, n0 - dy * signY)), s1 = max(N, min(S, s0 + dy * signY));\n          break;\n        }\n      }\n\n      if (e1 < w1) {\n        signX *= -1;\n        t = w0, w0 = e0, e0 = t;\n        t = w1, w1 = e1, e1 = t;\n        if (type in flipX) overlay.attr(\"cursor\", cursors[type = flipX[type]]);\n      }\n\n      if (s1 < n1) {\n        signY *= -1;\n        t = n0, n0 = s0, s0 = t;\n        t = n1, n1 = s1, s1 = t;\n        if (type in flipY) overlay.attr(\"cursor\", cursors[type = flipY[type]]);\n      }\n\n      if (state.selection) selection = state.selection; // May be set by brush.move!\n      if (lockX) w1 = selection[0][0], e1 = selection[1][0];\n      if (lockY) n1 = selection[0][1], s1 = selection[1][1];\n\n      if (selection[0][0] !== w1\n          || selection[0][1] !== n1\n          || selection[1][0] !== e1\n          || selection[1][1] !== s1) {\n        state.selection = [[w1, n1], [e1, s1]];\n        redraw.call(that);\n        emit.brush(event, mode.name);\n      }\n    }\n\n    function ended(event) {\n      nopropagation(event);\n      if (event.touches) {\n        if (event.touches.length) return;\n        if (touchending) clearTimeout(touchending);\n        touchending = setTimeout(function() { touchending = null; }, 500); // Ghost clicks are delayed!\n      } else {\n        dragEnable(event.view, moving);\n        view.on(\"keydown.brush keyup.brush mousemove.brush mouseup.brush\", null);\n      }\n      group.attr(\"pointer-events\", \"all\");\n      overlay.attr(\"cursor\", cursors.overlay);\n      if (state.selection) selection = state.selection; // May be set by brush.move (on start)!\n      if (empty(selection)) state.selection = null, redraw.call(that);\n      emit.end(event, mode.name);\n    }\n\n    function keydowned(event) {\n      switch (event.keyCode) {\n        case 16: { // SHIFT\n          shifting = signX && signY;\n          break;\n        }\n        case 18: { // ALT\n          if (mode === MODE_HANDLE) {\n            if (signX) e0 = e1 - dx * signX, w0 = w1 + dx * signX;\n            if (signY) s0 = s1 - dy * signY, n0 = n1 + dy * signY;\n            mode = MODE_CENTER;\n            move(event);\n          }\n          break;\n        }\n        case 32: { // SPACE; takes priority over ALT\n          if (mode === MODE_HANDLE || mode === MODE_CENTER) {\n            if (signX < 0) e0 = e1 - dx; else if (signX > 0) w0 = w1 - dx;\n            if (signY < 0) s0 = s1 - dy; else if (signY > 0) n0 = n1 - dy;\n            mode = MODE_SPACE;\n            overlay.attr(\"cursor\", cursors.selection);\n            move(event);\n          }\n          break;\n        }\n        default: return;\n      }\n      noevent(event);\n    }\n\n    function keyupped(event) {\n      switch (event.keyCode) {\n        case 16: { // SHIFT\n          if (shifting) {\n            lockX = lockY = shifting = false;\n            move(event);\n          }\n          break;\n        }\n        case 18: { // ALT\n          if (mode === MODE_CENTER) {\n            if (signX < 0) e0 = e1; else if (signX > 0) w0 = w1;\n            if (signY < 0) s0 = s1; else if (signY > 0) n0 = n1;\n            mode = MODE_HANDLE;\n            move(event);\n          }\n          break;\n        }\n        case 32: { // SPACE\n          if (mode === MODE_SPACE) {\n            if (event.altKey) {\n              if (signX) e0 = e1 - dx * signX, w0 = w1 + dx * signX;\n              if (signY) s0 = s1 - dy * signY, n0 = n1 + dy * signY;\n              mode = MODE_CENTER;\n            } else {\n              if (signX < 0) e0 = e1; else if (signX > 0) w0 = w1;\n              if (signY < 0) s0 = s1; else if (signY > 0) n0 = n1;\n              mode = MODE_HANDLE;\n            }\n            overlay.attr(\"cursor\", cursors[type]);\n            move(event);\n          }\n          break;\n        }\n        default: return;\n      }\n      noevent(event);\n    }\n  }\n\n  function touchmoved(event) {\n    emitter(this, arguments).moved(event);\n  }\n\n  function touchended(event) {\n    emitter(this, arguments).ended(event);\n  }\n\n  function initialize() {\n    var state = this.__brush || {selection: null};\n    state.extent = number2(extent.apply(this, arguments));\n    state.dim = dim;\n    return state;\n  }\n\n  brush.extent = function(_) {\n    return arguments.length ? (extent = typeof _ === \"function\" ? _ : constant(number2(_)), brush) : extent;\n  };\n\n  brush.filter = function(_) {\n    return arguments.length ? (filter = typeof _ === \"function\" ? _ : constant(!!_), brush) : filter;\n  };\n\n  brush.touchable = function(_) {\n    return arguments.length ? (touchable = typeof _ === \"function\" ? _ : constant(!!_), brush) : touchable;\n  };\n\n  brush.handleSize = function(_) {\n    return arguments.length ? (handleSize = +_, brush) : handleSize;\n  };\n\n  brush.keyModifiers = function(_) {\n    return arguments.length ? (keys = !!_, brush) : keys;\n  };\n\n  brush.on = function() {\n    var value = listeners.on.apply(listeners, arguments);\n    return value === listeners ? brush : value;\n  };\n\n  return brush;\n}\n","export default function(x) {\n  return Math.abs(x = Math.round(x)) >= 1e21\n      ? x.toLocaleString(\"en\").replace(/,/g, \"\")\n      : x.toString(10);\n}\n\n// Computes the decimal coefficient and exponent of the specified number x with\n// significant digits p, where x is positive and p is in [1, 21] or undefined.\n// For example, formatDecimalParts(1.23) returns [\"123\", 0].\nexport function formatDecimalParts(x, p) {\n  if ((i = (x = p ? x.toExponential(p - 1) : x.toExponential()).indexOf(\"e\")) < 0) return null; // NaN, ±Infinity\n  var i, coefficient = x.slice(0, i);\n\n  // The string returned by toExponential either has the form \\d\\.\\d+e[-+]\\d+\n  // (e.g., 1.2e+3) or the form \\de[-+]\\d+ (e.g., 1e+3).\n  return [\n    coefficient.length > 1 ? coefficient[0] + coefficient.slice(2) : coefficient,\n    +x.slice(i + 1)\n  ];\n}\n","import {formatDecimalParts} from \"./formatDecimal.js\";\n\nexport default function(x) {\n  return x = formatDecimalParts(Math.abs(x)), x ? x[1] : NaN;\n}\n","// [[fill]align][sign][symbol][0][width][,][.precision][~][type]\nvar re = /^(?:(.)?([<>=^]))?([+\\-( ])?([$#])?(0)?(\\d+)?(,)?(\\.\\d+)?(~)?([a-z%])?$/i;\n\nexport default function formatSpecifier(specifier) {\n  if (!(match = re.exec(specifier))) throw new Error(\"invalid format: \" + specifier);\n  var match;\n  return new FormatSpecifier({\n    fill: match[1],\n    align: match[2],\n    sign: match[3],\n    symbol: match[4],\n    zero: match[5],\n    width: match[6],\n    comma: match[7],\n    precision: match[8] && match[8].slice(1),\n    trim: match[9],\n    type: match[10]\n  });\n}\n\nformatSpecifier.prototype = FormatSpecifier.prototype; // instanceof\n\nexport function FormatSpecifier(specifier) {\n  this.fill = specifier.fill === undefined ? \" \" : specifier.fill + \"\";\n  this.align = specifier.align === undefined ? \">\" : specifier.align + \"\";\n  this.sign = specifier.sign === undefined ? \"-\" : specifier.sign + \"\";\n  this.symbol = specifier.symbol === undefined ? \"\" : specifier.symbol + \"\";\n  this.zero = !!specifier.zero;\n  this.width = specifier.width === undefined ? undefined : +specifier.width;\n  this.comma = !!specifier.comma;\n  this.precision = specifier.precision === undefined ? undefined : +specifier.precision;\n  this.trim = !!specifier.trim;\n  this.type = specifier.type === undefined ? \"\" : specifier.type + \"\";\n}\n\nFormatSpecifier.prototype.toString = function() {\n  return this.fill\n      + this.align\n      + this.sign\n      + this.symbol\n      + (this.zero ? \"0\" : \"\")\n      + (this.width === undefined ? \"\" : Math.max(1, this.width | 0))\n      + (this.comma ? \",\" : \"\")\n      + (this.precision === undefined ? \"\" : \".\" + Math.max(0, this.precision | 0))\n      + (this.trim ? \"~\" : \"\")\n      + this.type;\n};\n","import {formatDecimalParts} from \"./formatDecimal.js\";\n\nexport var prefixExponent;\n\nexport default function(x, p) {\n  var d = formatDecimalParts(x, p);\n  if (!d) return x + \"\";\n  var coefficient = d[0],\n      exponent = d[1],\n      i = exponent - (prefixExponent = Math.max(-8, Math.min(8, Math.floor(exponent / 3))) * 3) + 1,\n      n = coefficient.length;\n  return i === n ? coefficient\n      : i > n ? coefficient + new Array(i - n + 1).join(\"0\")\n      : i > 0 ? coefficient.slice(0, i) + \".\" + coefficient.slice(i)\n      : \"0.\" + new Array(1 - i).join(\"0\") + formatDecimalParts(x, Math.max(0, p + i - 1))[0]; // less than 1y!\n}\n","import {formatDecimalParts} from \"./formatDecimal.js\";\n\nexport default function(x, p) {\n  var d = formatDecimalParts(x, p);\n  if (!d) return x + \"\";\n  var coefficient = d[0],\n      exponent = d[1];\n  return exponent < 0 ? \"0.\" + new Array(-exponent).join(\"0\") + coefficient\n      : coefficient.length > exponent + 1 ? coefficient.slice(0, exponent + 1) + \".\" + coefficient.slice(exponent + 1)\n      : coefficient + new Array(exponent - coefficient.length + 2).join(\"0\");\n}\n","import formatDecimal from \"./formatDecimal.js\";\nimport formatPrefixAuto from \"./formatPrefixAuto.js\";\nimport formatRounded from \"./formatRounded.js\";\n\nexport default {\n  \"%\": (x, p) => (x * 100).toFixed(p),\n  \"b\": (x) => Math.round(x).toString(2),\n  \"c\": (x) => x + \"\",\n  \"d\": formatDecimal,\n  \"e\": (x, p) => x.toExponential(p),\n  \"f\": (x, p) => x.toFixed(p),\n  \"g\": (x, p) => x.toPrecision(p),\n  \"o\": (x) => Math.round(x).toString(8),\n  \"p\": (x, p) => formatRounded(x * 100, p),\n  \"r\": formatRounded,\n  \"s\": formatPrefixAuto,\n  \"X\": (x) => Math.round(x).toString(16).toUpperCase(),\n  \"x\": (x) => Math.round(x).toString(16)\n};\n","export default function(x) {\n  return x;\n}\n","import exponent from \"./exponent.js\";\nimport formatGroup from \"./formatGroup.js\";\nimport formatNumerals from \"./formatNumerals.js\";\nimport formatSpecifier from \"./formatSpecifier.js\";\nimport formatTrim from \"./formatTrim.js\";\nimport formatTypes from \"./formatTypes.js\";\nimport {prefixExponent} from \"./formatPrefixAuto.js\";\nimport identity from \"./identity.js\";\n\nvar map = Array.prototype.map,\n    prefixes = [\"y\",\"z\",\"a\",\"f\",\"p\",\"n\",\"µ\",\"m\",\"\",\"k\",\"M\",\"G\",\"T\",\"P\",\"E\",\"Z\",\"Y\"];\n\nexport default function(locale) {\n  var group = locale.grouping === undefined || locale.thousands === undefined ? identity : formatGroup(map.call(locale.grouping, Number), locale.thousands + \"\"),\n      currencyPrefix = locale.currency === undefined ? \"\" : locale.currency[0] + \"\",\n      currencySuffix = locale.currency === undefined ? \"\" : locale.currency[1] + \"\",\n      decimal = locale.decimal === undefined ? \".\" : locale.decimal + \"\",\n      numerals = locale.numerals === undefined ? identity : formatNumerals(map.call(locale.numerals, String)),\n      percent = locale.percent === undefined ? \"%\" : locale.percent + \"\",\n      minus = locale.minus === undefined ? \"−\" : locale.minus + \"\",\n      nan = locale.nan === undefined ? \"NaN\" : locale.nan + \"\";\n\n  function newFormat(specifier) {\n    specifier = formatSpecifier(specifier);\n\n    var fill = specifier.fill,\n        align = specifier.align,\n        sign = specifier.sign,\n        symbol = specifier.symbol,\n        zero = specifier.zero,\n        width = specifier.width,\n        comma = specifier.comma,\n        precision = specifier.precision,\n        trim = specifier.trim,\n        type = specifier.type;\n\n    // The \"n\" type is an alias for \",g\".\n    if (type === \"n\") comma = true, type = \"g\";\n\n    // The \"\" type, and any invalid type, is an alias for \".12~g\".\n    else if (!formatTypes[type]) precision === undefined && (precision = 12), trim = true, type = \"g\";\n\n    // If zero fill is specified, padding goes after sign and before digits.\n    if (zero || (fill === \"0\" && align === \"=\")) zero = true, fill = \"0\", align = \"=\";\n\n    // Compute the prefix and suffix.\n    // For SI-prefix, the suffix is lazily computed.\n    var prefix = symbol === \"$\" ? currencyPrefix : symbol === \"#\" && /[boxX]/.test(type) ? \"0\" + type.toLowerCase() : \"\",\n        suffix = symbol === \"$\" ? currencySuffix : /[%p]/.test(type) ? percent : \"\";\n\n    // What format function should we use?\n    // Is this an integer type?\n    // Can this type generate exponential notation?\n    var formatType = formatTypes[type],\n        maybeSuffix = /[defgprs%]/.test(type);\n\n    // Set the default precision if not specified,\n    // or clamp the specified precision to the supported range.\n    // For significant precision, it must be in [1, 21].\n    // For fixed precision, it must be in [0, 20].\n    precision = precision === undefined ? 6\n        : /[gprs]/.test(type) ? Math.max(1, Math.min(21, precision))\n        : Math.max(0, Math.min(20, precision));\n\n    function format(value) {\n      var valuePrefix = prefix,\n          valueSuffix = suffix,\n          i, n, c;\n\n      if (type === \"c\") {\n        valueSuffix = formatType(value) + valueSuffix;\n        value = \"\";\n      } else {\n        value = +value;\n\n        // Determine the sign. -0 is not less than 0, but 1 / -0 is!\n        var valueNegative = value < 0 || 1 / value < 0;\n\n        // Perform the initial formatting.\n        value = isNaN(value) ? nan : formatType(Math.abs(value), precision);\n\n        // Trim insignificant zeros.\n        if (trim) value = formatTrim(value);\n\n        // If a negative value rounds to zero after formatting, and no explicit positive sign is requested, hide the sign.\n        if (valueNegative && +value === 0 && sign !== \"+\") valueNegative = false;\n\n        // Compute the prefix and suffix.\n        valuePrefix = (valueNegative ? (sign === \"(\" ? sign : minus) : sign === \"-\" || sign === \"(\" ? \"\" : sign) + valuePrefix;\n        valueSuffix = (type === \"s\" ? prefixes[8 + prefixExponent / 3] : \"\") + valueSuffix + (valueNegative && sign === \"(\" ? \")\" : \"\");\n\n        // Break the formatted value into the integer “value” part that can be\n        // grouped, and fractional or exponential “suffix” part that is not.\n        if (maybeSuffix) {\n          i = -1, n = value.length;\n          while (++i < n) {\n            if (c = value.charCodeAt(i), 48 > c || c > 57) {\n              valueSuffix = (c === 46 ? decimal + value.slice(i + 1) : value.slice(i)) + valueSuffix;\n              value = value.slice(0, i);\n              break;\n            }\n          }\n        }\n      }\n\n      // If the fill character is not \"0\", grouping is applied before padding.\n      if (comma && !zero) value = group(value, Infinity);\n\n      // Compute the padding.\n      var length = valuePrefix.length + value.length + valueSuffix.length,\n          padding = length < width ? new Array(width - length + 1).join(fill) : \"\";\n\n      // If the fill character is \"0\", grouping is applied after padding.\n      if (comma && zero) value = group(padding + value, padding.length ? width - valueSuffix.length : Infinity), padding = \"\";\n\n      // Reconstruct the final output based on the desired alignment.\n      switch (align) {\n        case \"<\": value = valuePrefix + value + valueSuffix + padding; break;\n        case \"=\": value = valuePrefix + padding + value + valueSuffix; break;\n        case \"^\": value = padding.slice(0, length = padding.length >> 1) + valuePrefix + value + valueSuffix + padding.slice(length); break;\n        default: value = padding + valuePrefix + value + valueSuffix; break;\n      }\n\n      return numerals(value);\n    }\n\n    format.toString = function() {\n      return specifier + \"\";\n    };\n\n    return format;\n  }\n\n  function formatPrefix(specifier, value) {\n    var f = newFormat((specifier = formatSpecifier(specifier), specifier.type = \"f\", specifier)),\n        e = Math.max(-8, Math.min(8, Math.floor(exponent(value) / 3))) * 3,\n        k = Math.pow(10, -e),\n        prefix = prefixes[8 + e / 3];\n    return function(value) {\n      return f(k * value) + prefix;\n    };\n  }\n\n  return {\n    format: newFormat,\n    formatPrefix: formatPrefix\n  };\n}\n","import formatLocale from \"./locale.js\";\n\nvar locale;\nexport var format;\nexport var formatPrefix;\n\ndefaultLocale({\n  thousands: \",\",\n  grouping: [3],\n  currency: [\"$\", \"\"]\n});\n\nexport default function defaultLocale(definition) {\n  locale = formatLocale(definition);\n  format = locale.format;\n  formatPrefix = locale.formatPrefix;\n  return locale;\n}\n","export default function(grouping, thousands) {\n  return function(value, width) {\n    var i = value.length,\n        t = [],\n        j = 0,\n        g = grouping[0],\n        length = 0;\n\n    while (i > 0 && g > 0) {\n      if (length + g + 1 > width) g = Math.max(1, width - length);\n      t.push(value.substring(i -= g, i + g));\n      if ((length += g + 1) > width) break;\n      g = grouping[j = (j + 1) % grouping.length];\n    }\n\n    return t.reverse().join(thousands);\n  };\n}\n","export default function(numerals) {\n  return function(value) {\n    return value.replace(/[0-9]/g, function(i) {\n      return numerals[+i];\n    });\n  };\n}\n","// Trims insignificant zeros, e.g., replaces 1.2000k with 1.2k.\nexport default function(s) {\n  out: for (var n = s.length, i = 1, i0 = -1, i1; i < n; ++i) {\n    switch (s[i]) {\n      case \".\": i0 = i1 = i; break;\n      case \"0\": if (i0 === 0) i0 = i; i1 = i; break;\n      default: if (!+s[i]) break out; if (i0 > 0) i0 = 0; break;\n    }\n  }\n  return i0 > 0 ? s.slice(0, i0) + s.slice(i1 + 1) : s;\n}\n","import exponent from \"./exponent.js\";\n\nexport default function(step) {\n  return Math.max(0, -exponent(Math.abs(step)));\n}\n","import exponent from \"./exponent.js\";\n\nexport default function(step, value) {\n  return Math.max(0, Math.max(-8, Math.min(8, Math.floor(exponent(value) / 3))) * 3 - exponent(Math.abs(step)));\n}\n","import exponent from \"./exponent.js\";\n\nexport default function(step, max) {\n  step = Math.abs(step), max = Math.abs(max) - step;\n  return Math.max(0, exponent(max) - exponent(step)) + 1;\n}\n","var e10 = Math.sqrt(50),\n    e5 = Math.sqrt(10),\n    e2 = Math.sqrt(2);\n\nexport default function ticks(start, stop, count) {\n  var reverse,\n      i = -1,\n      n,\n      ticks,\n      step;\n\n  stop = +stop, start = +start, count = +count;\n  if (start === stop && count > 0) return [start];\n  if (reverse = stop < start) n = start, start = stop, stop = n;\n  if ((step = tickIncrement(start, stop, count)) === 0 || !isFinite(step)) return [];\n\n  if (step > 0) {\n    let r0 = Math.round(start / step), r1 = Math.round(stop / step);\n    if (r0 * step < start) ++r0;\n    if (r1 * step > stop) --r1;\n    ticks = new Array(n = r1 - r0 + 1);\n    while (++i < n) ticks[i] = (r0 + i) * step;\n  } else {\n    step = -step;\n    let r0 = Math.round(start * step), r1 = Math.round(stop * step);\n    if (r0 / step < start) ++r0;\n    if (r1 / step > stop) --r1;\n    ticks = new Array(n = r1 - r0 + 1);\n    while (++i < n) ticks[i] = (r0 + i) / step;\n  }\n\n  if (reverse) ticks.reverse();\n\n  return ticks;\n}\n\nexport function tickIncrement(start, stop, count) {\n  var step = (stop - start) / Math.max(0, count),\n      power = Math.floor(Math.log(step) / Math.LN10),\n      error = step / Math.pow(10, power);\n  return power >= 0\n      ? (error >= e10 ? 10 : error >= e5 ? 5 : error >= e2 ? 2 : 1) * Math.pow(10, power)\n      : -Math.pow(10, -power) / (error >= e10 ? 10 : error >= e5 ? 5 : error >= e2 ? 2 : 1);\n}\n\nexport function tickStep(start, stop, count) {\n  var step0 = Math.abs(stop - start) / Math.max(0, count),\n      step1 = Math.pow(10, Math.floor(Math.log(step0) / Math.LN10)),\n      error = step0 / step1;\n  if (error >= e10) step1 *= 10;\n  else if (error >= e5) step1 *= 5;\n  else if (error >= e2) step1 *= 2;\n  return stop < start ? -step1 : step1;\n}\n","export default function ascending(a, b) {\n  return a == null || b == null ? NaN : a < b ? -1 : a > b ? 1 : a >= b ? 0 : NaN;\n}\n","export default function descending(a, b) {\n  return a == null || b == null ? NaN\n    : b < a ? -1\n    : b > a ? 1\n    : b >= a ? 0\n    : NaN;\n}\n","import ascending from \"./ascending.js\";\nimport descending from \"./descending.js\";\n\nexport default function bisector(f) {\n  let compare1, compare2, delta;\n\n  // If an accessor is specified, promote it to a comparator. In this case we\n  // can test whether the search value is (self-) comparable. We can’t do this\n  // for a comparator (except for specific, known comparators) because we can’t\n  // tell if the comparator is symmetric, and an asymmetric comparator can’t be\n  // used to test whether a single value is comparable.\n  if (f.length !== 2) {\n    compare1 = ascending;\n    compare2 = (d, x) => ascending(f(d), x);\n    delta = (d, x) => f(d) - x;\n  } else {\n    compare1 = f === ascending || f === descending ? f : zero;\n    compare2 = f;\n    delta = f;\n  }\n\n  function left(a, x, lo = 0, hi = a.length) {\n    if (lo < hi) {\n      if (compare1(x, x) !== 0) return hi;\n      do {\n        const mid = (lo + hi) >>> 1;\n        if (compare2(a[mid], x) < 0) lo = mid + 1;\n        else hi = mid;\n      } while (lo < hi);\n    }\n    return lo;\n  }\n\n  function right(a, x, lo = 0, hi = a.length) {\n    if (lo < hi) {\n      if (compare1(x, x) !== 0) return hi;\n      do {\n        const mid = (lo + hi) >>> 1;\n        if (compare2(a[mid], x) <= 0) lo = mid + 1;\n        else hi = mid;\n      } while (lo < hi);\n    }\n    return lo;\n  }\n\n  function center(a, x, lo = 0, hi = a.length) {\n    const i = left(a, x, lo, hi - 1);\n    return i > lo && delta(a[i - 1], x) > -delta(a[i], x) ? i - 1 : i;\n  }\n\n  return {left, center, right};\n}\n\nfunction zero() {\n  return 0;\n}\n","import ascending from \"./ascending.js\";\nimport bisector from \"./bisector.js\";\nimport number from \"./number.js\";\n\nconst ascendingBisect = bisector(ascending);\nexport const bisectRight = ascendingBisect.right;\nexport const bisectLeft = ascendingBisect.left;\nexport const bisectCenter = bisector(number).center;\nexport default bisectRight;\n","export default function number(x) {\n  return x === null ? NaN : +x;\n}\n\nexport function* numbers(values, valueof) {\n  if (valueof === undefined) {\n    for (let value of values) {\n      if (value != null && (value = +value) >= value) {\n        yield value;\n      }\n    }\n  } else {\n    let index = -1;\n    for (let value of values) {\n      if ((value = valueof(value, ++index, values)) != null && (value = +value) >= value) {\n        yield value;\n      }\n    }\n  }\n}\n","export default function(a, b) {\n  return a = +a, b = +b, function(t) {\n    return Math.round(a * (1 - t) + b * t);\n  };\n}\n","export default function number(x) {\n  return +x;\n}\n","import {bisect} from \"d3-array\";\nimport {interpolate as interpolateValue, interpolateNumber, interpolateRound} from \"d3-interpolate\";\nimport constant from \"./constant.js\";\nimport number from \"./number.js\";\n\nvar unit = [0, 1];\n\nexport function identity(x) {\n  return x;\n}\n\nfunction normalize(a, b) {\n  return (b -= (a = +a))\n      ? function(x) { return (x - a) / b; }\n      : constant(isNaN(b) ? NaN : 0.5);\n}\n\nfunction clamper(a, b) {\n  var t;\n  if (a > b) t = a, a = b, b = t;\n  return function(x) { return Math.max(a, Math.min(b, x)); };\n}\n\n// normalize(a, b)(x) takes a domain value x in [a,b] and returns the corresponding parameter t in [0,1].\n// interpolate(a, b)(t) takes a parameter t in [0,1] and returns the corresponding range value x in [a,b].\nfunction bimap(domain, range, interpolate) {\n  var d0 = domain[0], d1 = domain[1], r0 = range[0], r1 = range[1];\n  if (d1 < d0) d0 = normalize(d1, d0), r0 = interpolate(r1, r0);\n  else d0 = normalize(d0, d1), r0 = interpolate(r0, r1);\n  return function(x) { return r0(d0(x)); };\n}\n\nfunction polymap(domain, range, interpolate) {\n  var j = Math.min(domain.length, range.length) - 1,\n      d = new Array(j),\n      r = new Array(j),\n      i = -1;\n\n  // Reverse descending domains.\n  if (domain[j] < domain[0]) {\n    domain = domain.slice().reverse();\n    range = range.slice().reverse();\n  }\n\n  while (++i < j) {\n    d[i] = normalize(domain[i], domain[i + 1]);\n    r[i] = interpolate(range[i], range[i + 1]);\n  }\n\n  return function(x) {\n    var i = bisect(domain, x, 1, j) - 1;\n    return r[i](d[i](x));\n  };\n}\n\nexport function copy(source, target) {\n  return target\n      .domain(source.domain())\n      .range(source.range())\n      .interpolate(source.interpolate())\n      .clamp(source.clamp())\n      .unknown(source.unknown());\n}\n\nexport function transformer() {\n  var domain = unit,\n      range = unit,\n      interpolate = interpolateValue,\n      transform,\n      untransform,\n      unknown,\n      clamp = identity,\n      piecewise,\n      output,\n      input;\n\n  function rescale() {\n    var n = Math.min(domain.length, range.length);\n    if (clamp !== identity) clamp = clamper(domain[0], domain[n - 1]);\n    piecewise = n > 2 ? polymap : bimap;\n    output = input = null;\n    return scale;\n  }\n\n  function scale(x) {\n    return x == null || isNaN(x = +x) ? unknown : (output || (output = piecewise(domain.map(transform), range, interpolate)))(transform(clamp(x)));\n  }\n\n  scale.invert = function(y) {\n    return clamp(untransform((input || (input = piecewise(range, domain.map(transform), interpolateNumber)))(y)));\n  };\n\n  scale.domain = function(_) {\n    return arguments.length ? (domain = Array.from(_, number), rescale()) : domain.slice();\n  };\n\n  scale.range = function(_) {\n    return arguments.length ? (range = Array.from(_), rescale()) : range.slice();\n  };\n\n  scale.rangeRound = function(_) {\n    return range = Array.from(_), interpolate = interpolateRound, rescale();\n  };\n\n  scale.clamp = function(_) {\n    return arguments.length ? (clamp = _ ? true : identity, rescale()) : clamp !== identity;\n  };\n\n  scale.interpolate = function(_) {\n    return arguments.length ? (interpolate = _, rescale()) : interpolate;\n  };\n\n  scale.unknown = function(_) {\n    return arguments.length ? (unknown = _, scale) : unknown;\n  };\n\n  return function(t, u) {\n    transform = t, untransform = u;\n    return rescale();\n  };\n}\n\nexport default function continuous() {\n  return transformer()(identity, identity);\n}\n","export default function constants(x) {\n  return function() {\n    return x;\n  };\n}\n","export function initRange(domain, range) {\n  switch (arguments.length) {\n    case 0: break;\n    case 1: this.range(domain); break;\n    default: this.range(range).domain(domain); break;\n  }\n  return this;\n}\n\nexport function initInterpolator(domain, interpolator) {\n  switch (arguments.length) {\n    case 0: break;\n    case 1: {\n      if (typeof domain === \"function\") this.interpolator(domain);\n      else this.range(domain);\n      break;\n    }\n    default: {\n      this.domain(domain);\n      if (typeof interpolator === \"function\") this.interpolator(interpolator);\n      else this.range(interpolator);\n      break;\n    }\n  }\n  return this;\n}\n","import {ticks, tickIncrement} from \"d3-array\";\nimport continuous, {copy} from \"./continuous.js\";\nimport {initRange} from \"./init.js\";\nimport tickFormat from \"./tickFormat.js\";\n\nexport function linearish(scale) {\n  var domain = scale.domain;\n\n  scale.ticks = function(count) {\n    var d = domain();\n    return ticks(d[0], d[d.length - 1], count == null ? 10 : count);\n  };\n\n  scale.tickFormat = function(count, specifier) {\n    var d = domain();\n    return tickFormat(d[0], d[d.length - 1], count == null ? 10 : count, specifier);\n  };\n\n  scale.nice = function(count) {\n    if (count == null) count = 10;\n\n    var d = domain();\n    var i0 = 0;\n    var i1 = d.length - 1;\n    var start = d[i0];\n    var stop = d[i1];\n    var prestep;\n    var step;\n    var maxIter = 10;\n\n    if (stop < start) {\n      step = start, start = stop, stop = step;\n      step = i0, i0 = i1, i1 = step;\n    }\n    \n    while (maxIter-- > 0) {\n      step = tickIncrement(start, stop, count);\n      if (step === prestep) {\n        d[i0] = start\n        d[i1] = stop\n        return domain(d);\n      } else if (step > 0) {\n        start = Math.floor(start / step) * step;\n        stop = Math.ceil(stop / step) * step;\n      } else if (step < 0) {\n        start = Math.ceil(start * step) / step;\n        stop = Math.floor(stop * step) / step;\n      } else {\n        break;\n      }\n      prestep = step;\n    }\n\n    return scale;\n  };\n\n  return scale;\n}\n\nexport default function linear() {\n  var scale = continuous();\n\n  scale.copy = function() {\n    return copy(scale, linear());\n  };\n\n  initRange.apply(scale, arguments);\n\n  return linearish(scale);\n}\n","import {tickStep} from \"d3-array\";\nimport {format, formatPrefix, formatSpecifier, precisionFixed, precisionPrefix, precisionRound} from \"d3-format\";\n\nexport default function tickFormat(start, stop, count, specifier) {\n  var step = tickStep(start, stop, count),\n      precision;\n  specifier = formatSpecifier(specifier == null ? \",f\" : specifier);\n  switch (specifier.type) {\n    case \"s\": {\n      var value = Math.max(Math.abs(start), Math.abs(stop));\n      if (specifier.precision == null && !isNaN(precision = precisionPrefix(step, value))) specifier.precision = precision;\n      return formatPrefix(specifier, value);\n    }\n    case \"\":\n    case \"e\":\n    case \"g\":\n    case \"p\":\n    case \"r\": {\n      if (specifier.precision == null && !isNaN(precision = precisionRound(step, Math.max(Math.abs(start), Math.abs(stop))))) specifier.precision = precision - (specifier.type === \"e\");\n      break;\n    }\n    case \"f\":\n    case \"%\": {\n      if (specifier.precision == null && !isNaN(precision = precisionFixed(step))) specifier.precision = precision - (specifier.type === \"%\") * 2;\n      break;\n    }\n  }\n  return format(specifier);\n}\n","var organismMetadata = {\n  9606: {\n    commonName: 'Human',\n    scientificName: 'Homo sapiens',\n    assemblies: {\n      default: 'GCF_000001405.26', // GRCh38\n      GRCh38: 'GCF_000001405.26',\n      GRCh37: 'GCF_000001405.13',\n      NCBI36: 'GCF_000001405.12'\n    },\n    hasGeneCache: true,\n    hasParalogCache: true,\n    hasInteractionCache: true,\n    hasGeneStructureCache: true,\n    hasProteinCache: true\n  },\n  10090: {\n    commonName: 'Mouse',\n    scientificName: 'Mus musculus',\n    assemblies: {\n      default: 'GCF_000001635.20', // GRCm38\n      GRCm38: 'GCF_000001635.20',\n      MGSCv37: 'GCF_000001635.18'\n    },\n    hasGeneCache: true,\n    hasParalogCache: true,\n    hasInteractionCache: true\n  },\n  9598: {\n    commonName: 'Chimpanzee',\n    scientificName: 'Pan troglodytes',\n    assemblies: {\n      'default': 'GCF_000001515.7',\n      'Pan_tro 3.0': 'GCF_000001515.7'\n    },\n    hasGeneCache: true,\n    hasParalogCache: true\n  },\n  10116: {\n    commonName: 'Rat',\n    scientificName: 'Rattus norvegicus',\n    assemblies: {\n      'default': 'GCF_000001895.5',\n      'Rnor_6.0': 'GCF_000001895.5'\n    },\n    hasGeneCache: true,\n    hasParalogCache: true\n  },\n  3702: {\n    commonName: 'Thale cress',\n    scientificName: 'Arabidopsis thaliana',\n    assemblies: {\n      default: 'GCF_000001735.3', // TAIR10\n      TAIR10: 'GCF_000001735.3'\n    }\n  },\n  4530: {\n    commonName: 'Rice',\n    scientificName: 'Oryza sativa',\n    assemblies: {\n      'default': 'GCA_001433935.1',\n      'IRGSP-1.0': 'GCA_001433935.1'\n    }\n  },\n  4577: {\n    commonName: 'Maize',\n    scientificName: 'Zea mays',\n    assemblies: {\n      'default': 'GCA_000005005.5',\n      'IRGSP-1.0': 'GCA_001433935.1'\n    }\n  },\n  4641: {\n    commonName: 'Banana',\n    scientificName: 'Musa acuminata',\n    assemblies: {\n      default: 'mock'\n    }\n  },\n  7227: {\n    commonName: 'Fly',\n    scientificName: 'Drosophila melanogaster',\n    assemblies: {\n      'default': 'GCA_000001215.4',\n      'Release 6 plus ISO1 MT': 'GCA_000001215.4'\n    }\n  },\n  7165: {\n    commonName: 'Mosquito',\n    scientificName: 'Anopheles gambiae',\n    assemblies: {\n      default: 'GCF_000005575.2'\n    }\n  },\n  746128: {\n    commonName: 'Aspergillis fumigatus',\n    scientificName: 'Aspergillis fumigatus',\n    assemblies: {\n      default: 'GCF_000002655.1'\n    }\n  },\n  227321: {\n    scientificName: 'Aspergillus nidulans',\n    assemblies: {\n      default: 'GCF_000149205.2'\n    }\n  },\n  5061: {\n    commonName: 'black mold',\n    scientificName: 'Aspergillus niger',\n    assemblies: {\n      default: 'GCF_003184595.1'\n    }\n  },\n  5062: {\n    commonName: 'koji',\n    scientificName: 'Aspergillus oryzae',\n    assemblies: {\n      default: 'GCF_000184455.2'\n    }\n  },\n  15368: {\n    commonName: 'stiff brome',\n    scientificName: 'Brachypodium distachyon',\n    assemblies: {\n      default: 'GCF_000005505.3'\n    }\n  },\n  60711: {\n    commonName: 'green monkey',\n    scientificName: 'Chlorocebus sabaeus',\n    assemblies: {\n      default: 'GCF_015252025.1'\n    }\n  },\n  7719: {\n    commonName: 'Vase tunicate',\n    scientificName: 'Ciona intestinalis',\n    assemblies: {\n      default: 'GCF_000224145.3'\n    }\n  },\n  9685: {\n    commonName: 'Cat',\n    scientificName: 'Felis catus',\n    assemblies: {\n      default: 'GCF_000181335.3'\n    },\n    hasGeneCache: true\n  },\n  9031: {\n    commonName: 'Chicken',\n    scientificName: 'Gallus gallus',\n    assemblies: {\n      default: 'GCF_000002315.6'\n    },\n    hasGeneCache: true,\n    hasParalogCache: true\n  },\n  9593: {\n    commonName: 'Gorilla',\n    scientificName: 'Gorilla gorilla',\n    assemblies: {\n      default: 'GCF_008122165.1'\n    }\n  },\n  4513: {\n    commonName: 'Barley',\n    scientificName: 'Hordeum vulgare',\n    assemblies: {\n      default: 'GCA_901482405.1'\n    }\n  },\n  9541: {\n    commonName: 'Crab-eating macaque',\n    scientificName: 'Macaca fascicularis',\n    assemblies: {\n      default: 'GCF_000364345.1'\n    },\n    hasGeneCache: true,\n    hasParalogCache: true\n  },\n  9544: {\n    commonName: 'Rhesus macaque',\n    scientificName: 'Macaca mulatta',\n    assemblies: {\n      default: 'GCF_003339765.1'\n    },\n    hasGeneCache: true,\n    hasParalogCache: true\n  },\n  9597: {\n    commonName: 'Bonobo',\n    scientificName: 'Pan paniscus',\n    assemblies: {\n      default: 'GCF_013052645.1'\n    }\n  },\n  9615: {\n    commonName: 'Dog',\n    scientificName: 'Canis lupus familiaris',\n    assemblies: {\n      default: 'GCF_014441545.1'\n    },\n    hasGeneCache: true,\n    hasParalogCache: true\n  },\n  4932: {\n    commonName: 'Yeast',\n    scientificName: 'Saccharomyces cerevisiae',\n    assemblies: {\n      default: 'GCA_000146045.2',\n      R64: 'GCA_000146045.2'\n    }\n  },\n  5833: {\n    commonName: 'malaria parasite',\n    scientificName: 'Plasmodium falciparum',\n    assemblies: {\n      default: 'GCA_000002765.3',\n      GCA_000002765: 'GCA_000002765.3'\n    }\n  },\n  6239: {\n    commonName: 'worm',\n    scientificName: 'Caenorhabditis elegans',\n    assemblies: {\n      default: 'GCF_000002985.6'\n    },\n    hasGeneCache: true,\n    hasParalogCache: true\n  },\n  4081: {\n    commonName: 'tomato',\n    scientificName: 'Solanum lycopersicum',\n    assemblies: {\n      default: 'GCF_000188115.4'\n    }\n  },\n  4072: {\n    commonName: 'pepper',\n    scientificName: 'Capsicum annuum',\n    assemblies: {\n      default: 'GCF_000710875.1'\n    }\n  }\n};\n\nexport {organismMetadata};\n","var staticColors, staticCss, staticGradients;\n\n// Gradient colors for each class, for polished rendering\nstaticColors = [\n  ['gneg', '#FFF', '#FFF', '#DDD'],\n  ['gpos25', '#C8C8C8', '#DDD', '#BBB'],\n  ['gpos33', '#BBB', '#BBB', '#AAA'],\n  ['gpos50', '#999', '#AAA', '#888'],\n  ['gpos66', '#888', '#888', '#666'],\n  ['gpos75', '#777', '#777', '#444'],\n  ['gpos100', '#444', '#666', '#000'],\n  ['acen', '#FEE', '#FEE', '#FDD'],\n  ['noBands', '#BBB', '#BBB', '#AAA']\n];\n\nstaticCss =\n  '#_ideogram {padding-left: 5px;} ' +\n  '#_ideogram .labeled {padding-left: 15px;} ' +\n  '#_ideogram.labeledLeft {padding-left: 15px; padding-top: 15px;} ' +\n  // Tahoma has great readability and space utilization at small sizes\n  // More: http://ux.stackexchange.com/a/3334\n  '#_ideogram text {font: 9px Tahoma; fill: #000;} ' +\n  '#_ideogram .italic {font-style: italic;} ' +\n  '#_ideogram .chromosome {cursor: pointer; fill: #AAA;}' +\n  '#_ideogram.no-rotate .chromosome {cursor: default;} ' +\n  '#_ideogram .chrLabel, #_ideogram .annot {cursor: pointer;}' +\n  '#_ideogram .chrSetLabel {font-weight: bolder;}' +\n  '#_ideogram .ghost {opacity: 0.2;}' +\n  '#_ideogram .hidden {display: none;}' +\n  '#_ideogram .bandLabelStalk line {stroke: #AAA; stroke-width: 1;}' +\n  '#_ideogram .syntenyBorder {stroke:#AAA;stroke-width:1;}' +\n  '#_ideogram rect.cursor {' +\n  '  fill: #F00;' +\n  '  stroke: #F00;' +\n  '  fill-opacity: .3;' +\n  '  shape-rendering: crispEdges;' +\n  '}' +\n  '#_ideogram .brush .selection {' +\n  '  fill: #F00;' +\n  '  stroke: #F00;' +\n  '  fill-opacity: .3;' +\n  '  shape-rendering: crispEdges;' +\n  '}' +\n  '#_ideogram .noBands {fill: #AAA;}' +\n  // NCBI stain density colors\n  '#_ideogram .gneg {fill: #FFF}' +\n  '#_ideogram .gpos25 {fill: #BBB}' +\n  '#_ideogram .gpos33 {fill: #AAA}' +\n  '#_ideogram .gpos50 {fill: #888}' +\n  '#_ideogram .gpos66 {fill: #666}' +\n  '#_ideogram .gpos75 {fill: #444}' +\n  '#_ideogram .gpos100 {fill: #000}' +\n  '#_ideogram .gpos {fill: #000}' +\n  '#_ideogram .acen {fill: #FDD}' +\n  '#_ideogram .stalk {fill: #CCE;}' +\n  '#_ideogram .gvar {fill: #DDF}' +\n  // Used when overlaid with annotations\n  '#_ideogram.faint .gneg {fill: #FFF}' +\n  '#_ideogram.faint .gpos25 {fill: #EEE}' +\n  '#_ideogram.faint .gpos33 {fill: #EEE}' +\n  '#_ideogram.faint .gpos50 {fill: #EEE}' +\n  '#_ideogram.faint .gpos66 {fill: #EEE}' +\n  '#_ideogram.faint .gpos75 {fill: #EEE}' +\n  '#_ideogram.faint .gpos100 {fill: #DDD}' +\n  '#_ideogram.faint .gpos {fill: #DDD}' +\n  '#_ideogram.faint .acen {fill: #FEE}' +\n  '#_ideogram.faint .stalk {fill: #EEF;}' +\n  '#_ideogram.faint .gvar {fill: #EEF}' +\n  // For sheen, i.e. the soft shine in chromosomes\n  '#_ideogram .gneg {fill: url(\"#gneg\")} ' +\n  '#_ideogram .gpos25 {fill: url(\"#gpos25\")} ' +\n  '#_ideogram .gpos33 {fill: url(\"#gpos33\")} ' +\n  '#_ideogram .gpos50 {fill: url(\"#gpos50\")} ' +\n  '#_ideogram .gpos66 {fill: url(\"#gpos66\")} ' +\n  '#_ideogram .gpos75 {fill: url(\"#gpos75\")} ' +\n  '#_ideogram .gpos100 {fill: url(\"#gpos100\")} ' +\n  '#_ideogram .gpos {fill: url(\"#gpos100\")} ' +\n  '#_ideogram .acen {fill: url(\"#acen\")} ' +\n  '#_ideogram .stalk {fill: url(\"#stalk\")} ' +\n  '#_ideogram .gvar {fill: url(\"#gvar\")} ' +\n  '#_ideogram .noBands {fill: url(\"#noBands\")} ' +\n  '#_ideogram .chromosome {fill: url(\"#noBands\")} ';\n\nstaticGradients =\n  '<pattern id=\"stalk\" width=\"2\" height=\"1\" patternUnits=\"userSpaceOnUse\" ' +\n  'patternTransform=\"rotate(30 0 0)\">' +\n  '<rect x=\"0\" y=\"0\" width=\"10\" height=\"2\" fill=\"#CCE\" /> ' +\n  '<line x1=\"0\" y1=\"0\" x2=\"0\" y2=\"100%\" style=\"stroke:#88B; ' +\n  'stroke-width:0.7;\" />' +\n  '</pattern>' +\n  '<pattern id=\"gvar\" width=\"2\" height=\"1\" patternUnits=\"userSpaceOnUse\" ' +\n  'patternTransform=\"rotate(-30 0 0)\">' +\n  '<rect x=\"0\" y=\"0\" width=\"10\" height=\"2\" fill=\"#DDF\" /> ' +\n  '<line x1=\"0\" y1=\"0\" x2=\"0\" y2=\"100%\" style=\"stroke:#99C; ' +\n  'stroke-width:0.7;\" />' +\n  '</pattern>';\n\nexport {staticColors, staticCss, staticGradients};\n","/**\n * @fileoverview A collection of Ideogram methods that don't fit elsewhere.\n */\n\nimport {select, selectAll} from 'd3-selection';\nimport * as d3fetch from 'd3-fetch';\nimport * as d3brush from 'd3-brush';\nimport * as d3dispatch from 'd3-dispatch';\nimport * as d3format from 'd3-format';\nimport {scaleLinear} from 'd3-scale';\nimport {max} from 'd3-array';\n\nimport {organismMetadata} from './init/organism-metadata';\n\nvar d3 = Object.assign(\n  {}, d3fetch, d3brush, d3dispatch, d3format\n);\n\nd3.select = select;\nd3.selectAll = selectAll;\nd3.scaleLinear = scaleLinear;\nd3.max = max;\n\n/**\n * Is the assembly in this.config an NCBI Assembly accession?\n *\n * @returns {boolean}\n */\nfunction assemblyIsAccession() {\n  return (\n    'assembly' in this.config &&\n    /(GCF_|GCA_)/.test(this.config.assembly)\n  );\n}\n\n/**\n * Is the assembly in this.config not from GenBank?\n *\n * @returns {boolean}\n */\nfunction hasNonGenBankAssembly(ideo) {\n  return (\n    'assembly' in ideo.config &&\n    /(GCA_)/.test(ideo.config.assembly) === false\n  );\n}\n\n/**\n * Is the assembly in this.config from GenBank?\n *\n * @returns {boolean}\n */\nfunction hasGenBankAssembly(ideo) {\n  return (\n    'assembly' in ideo.config &&\n    /(GCA_)/.test(ideo.config.assembly)\n  );\n}\n\nfunction getDir(dir) {\n  var script, tmp, protocol, dataDir, ideogramInLeaf,\n    scripts = document.scripts,\n    version = Ideogram.version;\n\n  if (location.pathname.includes('/examples/vanilla/') === false) {\n    return (\n      `https://cdn.jsdelivr.net/npm/ideogram@${version}/dist/data/${dir}`\n    );\n  }\n\n  for (var i = 0; i < scripts.length; i++) {\n    script = scripts[i];\n    ideogramInLeaf = /ideogram/.test(script.src.split('/').slice(-1));\n    if ('src' in script && ideogramInLeaf) {\n      tmp = script.src.split('//');\n      protocol = tmp[0];\n      tmp = '/' + tmp[1].split('/').slice(0, -2).join('/');\n      dataDir = protocol + '//' + tmp + '/data/' + dir;\n      return dataDir;\n    }\n  }\n\n  return '../data/' + dir;\n}\n\n/** Try request, and if failed then retry with URL lacking extension */\nfunction fetchWithRetry(url, isRetry=false) {\n  return fetch(url)\n    .then((response) => {\n      if (response.ok) {\n        return response;\n      } else {\n        if (isRetry === false) {\n          var urlWithoutExtension = url.replace('.json', '');\n          return fetchWithRetry(urlWithoutExtension, true);\n        } else {\n          throw Error('Fetch failed for ' + url);\n        }\n      }\n    });\n}\n\n/**\n * Returns directory used to fetch data for bands and annotations\n *\n * This simplifies ideogram configuration.  By default, the dataDir is\n * set to an external CDN unless we're serving from the local Ideogram\n * working directory\n *\n * @returns {String}\n */\nfunction getDataDir() {\n  return getDir('bands/native/');\n}\n\n/**\n * Rounds a float (e.g. SVG coordinate) to two decimal places\n *\n * @param coord Floating-point number, e.g. 42.1234567890\n * @returns {number} Rounded value, e.g. 42.12\n */\nfunction round(coord) {\n  // Per http://stackoverflow.com/a/9453447, below method is fastest\n  return Math.round(coord * 100) / 100;\n}\n\n/**\n * Convert e.g. 1000 to 1 k, 1500000 to 1.5 M, etc.\n * Used to format 1500000 base pairs to e.g. 1.5 Mbp\n *\n * Adapted from https://stackoverflow.com/a/9462382/10564415\n */\nfunction formatSiPrefix(num, digits) {\n  const lookup = [\n    {value: 1, symbol: ''},\n    {value: 1e3, symbol: 'k'},\n    {value: 1e6, symbol: 'M'},\n    {value: 1e9, symbol: 'G'},\n    {value: 1e12, symbol: 'T'},\n    {value: 1e15, symbol: 'P'},\n    {value: 1e18, symbol: 'E'}\n  ];\n  const rx = /\\.0+$|(\\.[0-9]*[1-9])0+$/;\n  var item = lookup.slice().reverse().find(function(item) {\n    return num >= item.value;\n  });\n  // eslint-disable-next-line max-len\n  return item ? (num / item.value).toFixed(digits).replace(rx, '$1') + ' ' + item.symbol : '0';\n}\n\nfunction onDidRotate(chrModel) {\n  call(this.onDidRotateCallback, chrModel);\n}\n\n/**\n * Get ideogram SVG container\n */\nfunction getSvg() {\n  return d3.select(this.selector).node();\n}\n\n/** Request data with Ideogram's authorization bearer token */\nfunction fetchWithAuth(url, contentType) {\n  var ideo = this,\n    config = ideo.config,\n    headers = new Headers();\n\n  if (config.accessToken) {\n    headers = new Headers({Authorization: 'Bearer ' + config.accessToken});\n  }\n\n  if (contentType === 'text') {\n    return d3.text(url, {headers: headers});\n  } else {\n    return d3.json(url, {headers: headers});\n  }\n}\n\n/** getTaxid(), but without need to initialize ideogram  */\nfunction getEarlyTaxid(name) {\n  name = slug(name);\n  for (const taxid in organismMetadata) {\n    const organism = organismMetadata[taxid];\n    const commonName = slug(organism.commonName);\n    const scientificName = slug(organism.scientificName);\n    if (commonName === name || scientificName === name) {\n      return taxid;\n    }\n  }\n\n  return null;\n}\n\n/**\n * Get organism's taxid (NCBI Taxonomy ID) given its common or scientific name\n */\nfunction getTaxid(name) {\n  var organism, taxid, commonName, scientificName,\n    ideo = this,\n    organisms = ideo.organisms;\n\n  name = slug(name);\n\n  for (taxid in organisms) {\n    organism = organisms[taxid];\n    commonName = slug(organism.commonName);\n    scientificName = slug(organism.scientificName);\n    if (commonName === name || scientificName === name) {\n      return taxid;\n    }\n  }\n\n  return null;\n}\n\n/**\n * Get organism's common name given its taxid\n */\nfunction getCommonName(taxid) {\n  var ideo = this;\n  if (taxid in ideo.organisms) {\n    return ideo.organisms[taxid].commonName;\n  }\n  return null;\n}\n\n/**\n * Get organism's scientific name given its taxid\n */\nfunction getScientificName(taxid) {\n  var ideo = this;\n  if (taxid in ideo.organisms) {\n    return ideo.organisms[taxid].scientificName;\n  }\n  return null;\n}\n\n/** Convert string to camelcase */\nexport function camel(str) {\n  const camelCaseString = str\n    .split(/[ _-]/g)\n    .map((token, i) => {\n      if (i > 0) {\n        return token[0].toUpperCase() + token.slice(1);\n      } else {\n        return token;\n      }\n    })\n    .join('');\n\n  return camelCaseString;\n}\n\n/**\n* Examples:\n* \"Homo sapiens\" -> \"homo-sapiens\"\n* \"Canis lupus familiaris\" -> \"canis-lupus-familiaris\"\n*/\nfunction slug(value) {\n  if (typeof value === 'undefined') return '';\n  return value.toLowerCase().replace(/ /g, '-');\n}\n\n// Determine if a string is a Roman numeral\n// From https://stackoverflow.com/a/48601418\nfunction isRoman(s) {\n  // http://stackoverflow.com/a/267405/1447675\n  return /^M{0,4}(CM|CD|D?C{0,3})(XC|XL|L?X{0,3})(IX|IV|V?I{0,3})$/i.test(s);\n}\n\n// Convert Roman numeral to integer\n// From https://stackoverflow.com/a/48601418\nfunction parseRoman(s) {\n  var val = {M: 1000, D: 500, C: 100, L: 50, X: 10, V: 5, I: 1};\n  return s.toUpperCase().split('').reduce(function(r, a, i, aa) {\n    return val[a] < val[aa[i + 1]] ? r - val[a] : r + val[a];\n  }, 0);\n}\n\n/**\n* Download a PNG image of the ideogram\n*\n* Includes any annotations, but not legend.\n*/\nfunction downloadPng(ideo) {\n  var ideoSvg = document.querySelector(ideo.selector);\n\n  // Create a hidden canvas.  This will contain the raster image to download.\n  var canvas = document.createElement('canvas');\n  var canvasId = '_ideo-undisplayed-dl-canvas';\n  canvas.setAttribute('style', 'display: none');\n  canvas.setAttribute('id', canvasId);\n  var width = ideoSvg.width.baseVal.value + 30;\n  var ideoSvgClone = ideoSvg.cloneNode(true);\n  ideoSvgClone.style.left = '';\n  canvas.setAttribute('width', width);\n  document.body.appendChild(canvas);\n\n  // Called after PNG image is created from data URL\n  function triggerDownload(imgUrl) {\n    var evt = new MouseEvent('click', {\n      view: window,\n      bubbles: false,\n      cancelable: true\n    });\n\n    var a = document.createElement('a');\n    a.setAttribute('download', 'ideogram.png');\n    a.setAttribute('href', imgUrl);\n    a.setAttribute('target', '_blank');\n\n    // Enables easy testing\n    a.setAttribute('id', '_ideo-undisplayed-dl-image-link');\n    a.setAttribute('style', 'display: none;');\n    document.body.appendChild(a);\n\n    a.dispatchEvent(evt);\n    canvas.remove();\n  }\n\n  var canvas = document.getElementById(canvasId);\n\n  // Enlarge canvas and disable smoothing, for higher resolution PNG\n  canvas.width *= 2;\n  canvas.height *= 2;\n  var ctx = canvas.getContext('2d');\n  ctx.setTransform(2, 0, 0, 2, 0, 0);\n  ctx.imageSmoothingEnabled = false;\n\n  var data = (new XMLSerializer()).serializeToString(ideoSvgClone);\n  var domUrl = window.URL || window.webkitURL || window;\n\n  var img = new Image();\n  var svgBlob = new Blob([data], {type: 'image/svg+xml;charset=utf-8'});\n  var url = domUrl.createObjectURL(svgBlob);\n\n  img.onload = function() {\n    ctx.drawImage(img, 0, 0);\n    domUrl.revokeObjectURL(url);\n\n    var imgUrl = canvas\n      .toDataURL('image/png')\n      .replace('image/png', 'image/octet-stream');\n\n    triggerDownload(imgUrl);\n  };\n\n  img.src = url;\n}\n\n\nfunction getFont(ideo) {\n  const config = ideo.config;\n\n  let family = 'sans-serif';\n  if (config.fontFamily) {\n    family = config.fontFamily;\n  }\n\n  const labelSize = config.annotLabelSize ? config.annotLabelSize : 13;\n  const font = '600 ' + labelSize + 'px ' + family;\n\n  return font;\n}\n\n/**\n * Get width and height of given text in pixels.\n *\n * Background: https://erikonarheim.com/posts/canvas-text-metrics/\n */\nfunction getTextSize(text, ideo) {\n  var font = getFont(ideo);\n\n  // re-use canvas object for better performance\n  var canvas =\n    getTextSize.canvas ||\n    (getTextSize.canvas = document.createElement('canvas'));\n  var context = canvas.getContext('2d');\n  context.font = font;\n  var metrics = context.measureText(text);\n\n  // metrics.width is less precise than technique below\n  var right = metrics.actualBoundingBoxRight;\n  var left = metrics.actualBoundingBoxLeft;\n  var width = Math.abs(left) + Math.abs(right);\n\n  const height =\n    Math.abs(metrics.actualBoundingBoxAscent) +\n    Math.abs(metrics.actualBoundingBoxDescent);\n\n  return {width, height};\n}\n\n/** Clone a nested array */\nfunction deepCopy(array) {\n  return JSON.parse(JSON.stringify(array));\n}\n\nexport {\n  assemblyIsAccession, hasNonGenBankAssembly, hasGenBankAssembly, getDataDir,\n  getDir, round, formatSiPrefix, onDidRotate, getSvg, d3, getEarlyTaxid,\n  getTaxid, getCommonName, getScientificName, slug, isRoman, parseRoman,\n  downloadPng, fetchWithRetry, getTextSize, getFont, deepCopy,\n  fetchWithAuth as fetch\n};\n","import array from \"./array.js\";\nimport {Selection, root} from \"./selection/index.js\";\n\nexport default function(selector) {\n  return typeof selector === \"string\"\n      ? new Selection([document.querySelectorAll(selector)], [document.documentElement])\n      : new Selection([selector == null ? [] : array(selector)], root);\n}\n","export default function max(values, valueof) {\n  let max;\n  if (valueof === undefined) {\n    for (const value of values) {\n      if (value != null\n          && (max < value || (max === undefined && value >= value))) {\n        max = value;\n      }\n    }\n  } else {\n    let index = -1;\n    for (let value of values) {\n      if ((value = valueof(value, ++index, values)) != null\n          && (max < value || (max === undefined && value >= value))) {\n        max = value;\n      }\n    }\n  }\n  return max;\n}\n","import {organismMetadata} from './organism-metadata';\nimport {staticCss} from './../bands/styles';\n\nfunction configurePloidy(ideo) {\n  if (!ideo.config.ploidy) ideo.config.ploidy = 1;\n\n  if (ideo.config.ploidy > 1) {\n    ideo.sexChromosomes = {};\n    if (!ideo.config.sex) {\n      // Default to 'male' per human, mouse reference genomes.\n      // TODO: The default sex value should probably be the heterogametic sex,\n      // i.e. whichever sex has allosomes that differ in morphology.\n      // In mammals and most insects that is the male.\n      // However, in birds and reptiles, that is female.\n      ideo.config.sex = 'male';\n    }\n    if (ideo.config.ploidy === 2 && !ideo.config.ancestors) {\n      ideo.config.ancestors = {M: '#ffb6c1', P: '#add8e6'};\n      ideo.config.ploidyDesc = 'MP';\n    }\n  }\n}\n\nfunction configureHeight(ideo) {\n  var container, rect, chrHeight;\n\n  if (!ideo.config.chrHeight) {\n    container = ideo.config.container;\n    rect = document.querySelector(container).getBoundingClientRect();\n\n    if (ideo.config.orientation === 'vertical') {\n      chrHeight = rect.height;\n    } else {\n      chrHeight = rect.width;\n    }\n\n    if (container === 'body' || chrHeight === 0) chrHeight = 400;\n    ideo.config.chrHeight = chrHeight;\n  }\n}\n\nfunction configureWidth(ideo) {\n  var chrWidth, chrHeight;\n\n  if (!ideo.config.chrWidth) {\n    chrWidth = 10;\n    chrHeight = ideo.config.chrHeight;\n\n    if (chrHeight < 900 && chrHeight > 500) {\n      chrWidth = Math.round(chrHeight / 40);\n    } else if (chrHeight >= 900) {\n      chrWidth = Math.round(chrHeight / 45);\n    }\n    ideo.config.chrWidth = chrWidth;\n  }\n}\n\nfunction configureMargin(ideo) {\n  if (ideo.config.geometry && ideo.config.geometry === 'collinear') {\n    if ('chrMargin' in ideo.config === false) {\n      ideo.config.chrMargin = 0;\n    }\n    return;\n  }\n  if (!ideo.config.chrMargin) {\n    if (ideo.config.ploidy === 1) {\n      ideo.config.chrMargin = 10;\n    } else {\n      // Defaults polyploid chromosomes to relatively small interchromatid gap\n      ideo.config.chrMargin = Math.round(ideo.config.chrWidth / 4);\n    }\n  }\n  if (ideo.config.showBandLabels) ideo.config.chrMargin += 20;\n}\n\nfunction configureBump(ideo) {\n  ideo.bump = Math.round(ideo.config.chrHeight / 125);\n  ideo.adjustedBump = false;\n  if (ideo.config.chrHeight < 200) {\n    ideo.adjustedBump = true;\n    ideo.bump = 4;\n  }\n}\n\nfunction configureSingleChromosome(config, ideo) {\n  if (config.chromosome) {\n    ideo.config.chromosomes = [config.chromosome];\n    if ('showBandLabels' in config === false) {\n      ideo.config.showBandLabels = true;\n    }\n    if ('rotatable' in config === false) ideo.config.rotatable = false;\n  }\n}\n\nfunction configureOrganisms(config, ideo) {\n  ideo.organisms = Object.assign({}, organismMetadata);\n  if (config.taxid && config.organismMetadata) ideo.organisms[config.taxid] = config.organismMetadata\n  ideo.organismsWithBands = Object.assign({}, ideo.organisms);\n}\n\nfunction configureCallbacks(config, ideo) {\n  if (config.onLoad) ideo.onLoadCallback = config.onLoad;\n  if (config.onLoadAnnots) ideo.onLoadAnnotsCallback = config.onLoadAnnots;\n  if (config.onDrawAnnots) ideo.onDrawAnnotsCallback = config.onDrawAnnots;\n  if (config.onBrushMove) ideo.onBrushMoveCallback = config.onBrushMove;\n  if (config.onBrushEnd) ideo.onBrushEndCallback = config.onBrushEnd;\n  if (config.onCursorMove) ideo.onCursorMoveCallback = config.onCursorMove;\n  if (config.onDidRotate) ideo.onDidRotateCallback = config.onDidRotate;\n  if (config.onWillShowAnnotTooltip) {\n    ideo.onWillShowAnnotTooltipCallback = config.onWillShowAnnotTooltip;\n  }\n  if (config.onDidShowAnnotTooltip) {\n    ideo.onDidShowAnnotTooltipCallback = config.onDidShowAnnotTooltip;\n  }\n  if (config.onClickAnnot) {\n    ideo.onClickAnnotCallback = config.onClickAnnot;\n  }\n}\n\nfunction configureMiscellaneous(ideo) {\n  ideo.chromosomesArray = [];\n  ideo.coordinateSystem = 'iscn';\n  ideo.maxLength = {bp: 0, iscn: 0};\n  ideo.chromosomes = {};\n  ideo.numChromosomes = 0;\n  if (!ideo.config.debug) ideo.config.debug = false;\n  if (!ideo.config.dataDir) ideo.config.dataDir = ideo.getDataDir();\n  if (!ideo.config.container) ideo.config.container = 'body';\n  ideo.selector = ideo.config.container + ' #_ideogram';\n  if (!ideo.config.resolution) ideo.config.resolution = '';\n  if (!ideo.config.orientation) ideo.config.orientation = 'vertical';\n  if (!ideo.config.brush) ideo.config.brush = null;\n  if (!ideo.config.rows) ideo.config.rows = 1;\n  if ('showChromosomeLabels' in ideo.config === false) {\n    ideo.config.showChromosomeLabels = true;\n  }\n  if (!ideo.config.showNonNuclearChromosomes) {\n    ideo.config.showNonNuclearChromosomes = false;\n  }\n  if (!ideo.config.chromosomeScale) {\n    ideo.config.chromosomeScale = 'absolute';\n  }\n  if (!ideo.config.showTools) ideo.config.showTools = false;\n}\n\nfunction configureBands(ideo) {\n  if (!ideo.config.showBandLabels) ideo.config.showBandLabels = false;\n\n  if ('showFullyBanded' in ideo.config === false) {\n    ideo.config.showFullyBanded = true;\n  }\n\n  ideo.bandsToShow = [];\n  ideo.bandData = {};\n}\n\nlet configuredCss = staticCss;\nfunction configureTextStyle(ideo) {\n  const config = ideo.config;\n  if (!config.chrLabelSize) ideo.config.chrLabelSize = 9;\n  if (!config.chrLabelColor) ideo.config.chrLabelColor = '#000';\n  if (!config.fontFamily) ideo.config.fontFamily = '';\n\n  const size = `font-size: ${config.chrLabelSize}px`;\n  const color = `fill: ${config.chrLabelColor}`;\n  const fontFamily = `font-family: ${config.fontFamily}`;\n  configuredCss += `#_ideogram text {${fontFamily}; ${size}; ${color};}`;\n  configuredCss += `#_ideogramLabel text {${fontFamily};}`;\n}\n\n/**\n * High-level helper method for Ideogram constructor.\n *\n * @param config Configuration object.  Enables setting Ideogram properties.\n *\n * Docs: https://github.com/eweitz/ideogram/blob/master/api.md\n */\nfunction configure(config) {\n  // Clone the config object, to allow multiple instantiations\n  // without picking up prior ideogram's settings\n  this.config = JSON.parse(JSON.stringify(config));\n\n  configureMiscellaneous(this);\n  configurePloidy(this);\n  configureBands(this);\n  configureHeight(this);\n  configureWidth(this);\n  configureMargin(this);\n  configureCallbacks(config, this);\n  configureOrganisms(config, this);\n  configureBump(this);\n  configureSingleChromosome(config, this);\n  configureTextStyle(this);\n  this.initAnnotSettings();\n  if (!this.config.geometry || this.config.geometry === 'parallel') {\n    this.config.chrMargin += this.config.chrWidth;\n    if (this.config.annotationsLayout === 'heatmap') {\n      this.config.chrMargin += this.config.annotTracksHeight;\n    } else {\n      this.config.chrMargin += this.config.annotTracksHeight * 2;\n    }\n  }\n  this.init();\n}\n\nexport {configure, configuredCss};\n","/**\n * @fileoverview Functions for collinear chromosomes.\n * Collinear chromosomes form a line together, unlike the default parallel\n * geometry.\n */\n\nimport {d3} from './lib';\n\nfunction labelGenomes(ideo) {\n\n  ideo.config.taxids.forEach((taxid, i) => {\n    var org = ideo.organisms[taxid];\n    // var commonName = slug(org.commonName);\n    var scientificName = org.scientificName;\n    d3.select(ideo.selector)\n      .append('text')\n      .attr('class', 'genomeLabel italic')\n      .attr('x', 55 + 200 * i)\n      .attr('y', 10)\n      .text(scientificName)\n      .attr('text-anchor', 'middle');\n  });\n}\n\n/**\n* Rearrange chromosomes from parallel vertical to collinear vertical\n*\n* Parallel vertical (as in https://eweitz.github.io/ideogram/human)\n* | | |\n*\n* Collinear vertical (as in https://eweitz.github.io/ideogram/orthologs?loci=2:150000000,5:20000000;3:100000000,10:80000000&org=homo-sapiens&org2=mus-musculus)\n* |\n* |\n* |\n*/\nfunction rearrangeChromosomes(chrSets, yOffsets, x, ideo) {\n  var i, chrSet, y, chrLabelX, adjustedX, chr, taxid, orgIndex,\n    config = ideo.config,\n    chrLabelSize = config.chrLabelSize;\n\n  for (i = 0; i < chrSets.length; i++) {\n    chrSet = chrSets[i];\n    y = yOffsets[i] + 23 - chrLabelSize;\n\n    chr = ideo.chromosomesArray[i];\n    taxid = chr.id.split('-')[1];\n    orgIndex = ideo.config.taxids.indexOf(taxid);\n    adjustedX = x - orgIndex * 200 - 30 - 5;\n    if (orgIndex === 0) {\n      chrLabelX = -34;\n      adjustedX += ideo.config.chrWidth * 2 - 16;\n    } else {\n      chrLabelX = ideo.config.chrWidth * 2 - 24;\n    }\n\n    if (config.showChromosomeLabels) {\n      const labelSpan = chrSet.querySelector('.chrLabel > tspan');\n      labelSpan.setAttribute('x', chrLabelX);\n      labelSpan.setAttribute('dy', chrLabelSize - 8);\n      chrSet.querySelector('.chrLabel').setAttribute('text-anchor', 'start');\n    }\n    chrSet.setAttribute(\n      'transform', 'rotate(90) translate(' + y + ',' + adjustedX + ')'\n    );\n    chrSet.querySelector('.chromosome').setAttribute(\n      'transform', 'translate(-13, 10)'\n    );\n  }\n\n  labelGenomes(ideo);\n}\n\n/**\n* Get pixel coordinates to use for rearrangement\n*/\nfunction getYOffsets(chrSets, ideo) {\n  var yOffsets, i, index, chr, prevChr, y, prevWidth, prevY, yBump, taxid,\n    seenTaxids = {};\n\n  yOffsets = [];\n  for (i = 0; i < chrSets.length; i++) {\n    chr = ideo.chromosomesArray[i];\n    taxid = chr.id.split('-')[1];\n    index = (i === 0) ? i : i - 1;\n    prevChr = ideo.chromosomesArray[index];\n    if (i === 0 || taxid in seenTaxids === false) {\n      y = 20;\n      seenTaxids[taxid] = 1;\n    } else {\n      prevWidth = prevChr.width;\n      prevY = yOffsets[index];\n      yBump = (ideo.config.showChromosomeLabels ? 0 : 2);\n      y = prevY + prevWidth + yBump + ideo.config.chrMargin;\n    }\n    yOffsets.push(y);\n  }\n\n  return yOffsets;\n}\n\nfunction collinearizeVerticalChromosomes(ideo) {\n  var chrSets, yOffsets, x, height, width,\n    config = ideo.config;\n\n  ideo.config.annotLabelHeight = 12;\n  // var annotLabelHeight = ideo.config.annotLabelHeight;\n\n  if ('demarcateCollinearChromosomes' in ideo.config === false) {\n    ideo.config.demarcateCollinearChromosomes = true;\n  }\n\n  chrSets = document.querySelectorAll('.chromosome-set');\n\n  x = -40;\n\n  yOffsets = getYOffsets(chrSets, ideo);\n  rearrangeChromosomes(chrSets, yOffsets, x, ideo);\n\n  width = Math.round(yOffsets.slice(-1)[0] + 70);\n\n  if (config.multiorganism) {\n    height *= 8;\n    var maxHeight = 0;\n    yOffsets.forEach(d => {\n      if (d > maxHeight) maxHeight = d;\n    });\n    height = maxHeight + 30;\n  } else {\n    height = xOffsets.slice(-1)[0] + 30;\n  }\n\n  d3.select(ideo.selector)\n    .attr('height', height)\n    .attr('width', width);\n\n  d3.select('#_ideogramTrackLabelContainer').remove();\n  d3.select('#_ideogramInnerWrap')\n    .insert('div', ':first-child')\n    .attr('id', '_ideogramTrackLabelContainer')\n    .style('position', 'absolute');\n}\n\nexport default collinearizeVerticalChromosomes;\n","/**\n * @fileoverview Functions for collinear chromosomes.\n * Collinear chromosomes form a line together, unlike the default parallel\n * geometry.\n */\n\nimport {d3} from './lib';\nimport collinearizeVerticalChromosomes from './collinear-vertical';\n\nfunction labelGenomes(ideo) {\n\n  ideo.config.taxids.forEach((taxid, i) => {\n    var org = ideo.organisms[taxid];\n    var config = ideo.config;\n    // var commonName = slug(org.commonName);\n    var scientificName = org.scientificName;\n    d3.select(ideo.selector)\n      .append('text')\n      .attr('class', 'genomeLabel italic')\n      .attr('x', 5)\n      .attr('y', config.chrLabelSize + (200 + (3 * config.chrWidth)) * i)\n      .text(scientificName);\n  });\n}\n\n/**\n* Rearrange chromosomes from parallel horizontal to collinear horizontal\n*\n* Parallel horizontal (as in https://eweitz.github.io/ideogram/mouse)\n*     ---\n*     ---\n*     ---\n*\n* Collinear horizontal (as in https://eweitz.github.io/ideogram/geometry-collinear):\n*     --- --- ---\n*/\nfunction rearrangeChromosomes(chrSets, xOffsets, y, ideo) {\n  var i, chr, chrSet, taxid, x, adjustedY, orgIndex, chrLabelY,\n    config = ideo.config,\n    chrWidth = config.chrWidth,\n    chrLabelSize = config.chrLabelSize;\n\n  for (i = 0; i < chrSets.length; i++) {\n    chrSet = chrSets[i];\n    x = xOffsets[i];\n\n    chr = ideo.chromosomesArray[i];\n    taxid = chr.id.split('-')[1];\n    orgIndex = config.taxids.indexOf(taxid);\n    adjustedY = y + orgIndex * 200;\n    if (orgIndex === 0 && ideo.config.multiorganism) {\n      chrLabelY = chrLabelSize - 4;\n      adjustedY += chrWidth * 2 + chrLabelSize;\n    } else {\n      chrLabelY = chrWidth * 2 + chrLabelSize + 2;\n    }\n\n    if (ideo.config.showChromosomeLabels) {\n      chrSet.querySelector('.chrLabel').setAttribute('y', chrLabelY);\n      chrSet.querySelector('.chrLabel').setAttribute('text-anchor', 'middle');\n    }\n    chrSet.setAttribute('transform', 'translate(' + x + ',' + adjustedY + ')');\n    chrSet.querySelector('.chromosome').setAttribute(\n      'transform', 'translate(-13, 10)'\n    );\n  }\n\n  if (config.multiorganism) {\n    labelGenomes(ideo);\n  }\n}\n\n/**\n* Get pixel coordinates to use for rearrangement\n*/\nfunction getXOffsets(chrSets, ideo) {\n  var xOffsets, i, index, chr, prevChr, x, prevWidth, prevX, xBump, taxid,\n    seenTaxids = {};\n\n  xOffsets = [];\n  for (i = 0; i < chrSets.length; i++) {\n    chr = ideo.chromosomesArray[i];\n    taxid = chr.id.split('-')[1];\n    index = (i === 0) ? i : i - 1;\n    prevChr = ideo.chromosomesArray[index];\n    if (i === 0 || taxid in seenTaxids === false) {\n      x = 20;\n      seenTaxids[taxid] = 1;\n    } else {\n      prevWidth = prevChr.width;\n      prevX = xOffsets[index];\n      xBump = (ideo.config.showChromosomeLabels ? 0 : 2);\n      x = prevX + prevWidth + xBump + ideo.config.chrMargin;\n    }\n    xOffsets.push(x);\n  }\n\n  return xOffsets;\n}\n\n// /**\n//  * Track number of chromosomes in preceding organisms.\n//  * Adds an instance variable to the ideogram object to offset\n//  * chromosome indices.  Needed for multiorganism collinear ideograms.\n//  */\n// function setTaxidChrOffsets(ideo) {\n//   var taxidChrOffsets, taxidChrOffset;\n\n//   taxidChrOffsets = {};\n\n//   taxidChrOffset = 0;\n//   ideo.config.organism.forEach((org) => {\n//     var taxid, numChrs;\n//     taxid = ideo.getTaxid(org);\n//     taxidChrOffsets[taxid] = taxidChrOffset;\n//     numChrs = Object.keys(ideo.chromosomes[taxid]).length;\n//     taxidChrOffset += numChrs;\n//   });\n\n//   ideo.taxidChrOffsets = taxidChrOffsets;\n// }\n\n// /**\n//  * Change chromosome indices for multiorganism collinear ideograms\n//  * This is needed to account for x-offsets.\n//  */\n// function adjustChrIndex(ideo) {\n//   setTaxidChrOffsets(ideo);\n\n//   ideo.chromosomesArray.map((chr) => {\n//     var taxid = chr.id.split('-')[1];\n//     var taxidChrOffset = ideo.taxidChrOffsets[taxid];\n//     chr.chrIndex -= taxidChrOffset;\n//     ideo.chromosomes[taxid][chr.name].chrIndex = chr.chrIndex;\n//   });\n// }\n\nfunction collinearizeChromosomes(ideo) {\n  var chrSets, xOffsets, y, height, width,\n    config = ideo.config,\n    annotHeight = config.annotationHeight || 0;\n\n  if (config.orientation === 'vertical') {\n    collinearizeVerticalChromosomes(ideo);\n    return;\n  }\n\n  // if (config.multiorganism) adjustChrIndex(ideo);\n\n  ideo.config.annotLabelHeight = 12;\n  var annotLabelHeight = ideo.config.annotLabelHeight;\n\n  if ('demarcateCollinearChromosomes' in ideo.config === false) {\n    ideo.config.demarcateCollinearChromosomes = true;\n  }\n\n  chrSets = document.querySelectorAll('.chromosome-set');\n\n  y = (\n    (config.numAnnotTracks * (annotHeight + annotLabelHeight + 4)) -\n    config.chrWidth + 1\n  );\n\n  xOffsets = getXOffsets(chrSets, ideo);\n  rearrangeChromosomes(chrSets, xOffsets, y, ideo);\n\n  height = y + config.chrWidth * 2 + 20;\n\n  if (config.multiorganism) {\n    height *= 8;\n    var maxWidth = 0;\n    xOffsets.forEach(d => {\n      if (d > maxWidth) maxWidth = d;\n    });\n    width = maxWidth + 20;\n  } else {\n    width = xOffsets.slice(-1)[0] + 20;\n  }\n\n  d3.select(ideo.selector)\n    .attr('width', width)\n    .attr('height', height);\n\n  d3.select('#_ideogramTrackLabelContainer').remove();\n  d3.select('#_ideogramInnerWrap')\n    .insert('div', ':first-child')\n    .attr('id', '_ideogramTrackLabelContainer')\n    .style('position', 'absolute');\n}\n\nexport default collinearizeChromosomes;\n","// DEFLATE is a complex format; to read this code, you should probably check the RFC first:\n// https://tools.ietf.org/html/rfc1951\n// You may also wish to take a look at the guide I made about this program:\n// https://gist.github.com/101arrowz/253f31eb5abc3d9275ab943003ffecad\n// Some of the following code is similar to that of UZIP.js:\n// https://github.com/photopea/UZIP.js\n// However, the vast majority of the codebase has diverged from UZIP.js to increase performance and reduce bundle size.\n// Sometimes 0 will appear where -1 would be more appropriate. This is because using a uint\n// is better for memory in most engines (I *think*).\nvar ch2 = {};\nvar wk = (function (c, id, msg, transfer, cb) {\n    var w = new Worker(ch2[id] || (ch2[id] = URL.createObjectURL(new Blob([\n        c + ';addEventListener(\"error\",function(e){e=e.error;postMessage({$e$:[e.message,e.code,e.stack]})})'\n    ], { type: 'text/javascript' }))));\n    w.onmessage = function (e) {\n        var d = e.data, ed = d.$e$;\n        if (ed) {\n            var err = new Error(ed[0]);\n            err['code'] = ed[1];\n            err.stack = ed[2];\n            cb(err, null);\n        }\n        else\n            cb(null, d);\n    };\n    w.postMessage(msg, transfer);\n    return w;\n});\n\n// aliases for shorter compressed code (most minifers don't do this)\nvar u8 = Uint8Array, u16 = Uint16Array, u32 = Uint32Array;\n// fixed length extra bits\nvar fleb = new u8([0, 0, 0, 0, 0, 0, 0, 0, 1, 1, 1, 1, 2, 2, 2, 2, 3, 3, 3, 3, 4, 4, 4, 4, 5, 5, 5, 5, 0, /* unused */ 0, 0, /* impossible */ 0]);\n// fixed distance extra bits\n// see fleb note\nvar fdeb = new u8([0, 0, 0, 0, 1, 1, 2, 2, 3, 3, 4, 4, 5, 5, 6, 6, 7, 7, 8, 8, 9, 9, 10, 10, 11, 11, 12, 12, 13, 13, /* unused */ 0, 0]);\n// code length index map\nvar clim = new u8([16, 17, 18, 0, 8, 7, 9, 6, 10, 5, 11, 4, 12, 3, 13, 2, 14, 1, 15]);\n// get base, reverse index map from extra bits\nvar freb = function (eb, start) {\n    var b = new u16(31);\n    for (var i = 0; i < 31; ++i) {\n        b[i] = start += 1 << eb[i - 1];\n    }\n    // numbers here are at max 18 bits\n    var r = new u32(b[30]);\n    for (var i = 1; i < 30; ++i) {\n        for (var j = b[i]; j < b[i + 1]; ++j) {\n            r[j] = ((j - b[i]) << 5) | i;\n        }\n    }\n    return [b, r];\n};\nvar _a = freb(fleb, 2), fl = _a[0], revfl = _a[1];\n// we can ignore the fact that the other numbers are wrong; they never happen anyway\nfl[28] = 258, revfl[258] = 28;\nvar _b = freb(fdeb, 0), fd = _b[0], revfd = _b[1];\n// map of value to reverse (assuming 16 bits)\nvar rev = new u16(32768);\nfor (var i = 0; i < 32768; ++i) {\n    // reverse table algorithm from SO\n    var x = ((i & 0xAAAA) >>> 1) | ((i & 0x5555) << 1);\n    x = ((x & 0xCCCC) >>> 2) | ((x & 0x3333) << 2);\n    x = ((x & 0xF0F0) >>> 4) | ((x & 0x0F0F) << 4);\n    rev[i] = (((x & 0xFF00) >>> 8) | ((x & 0x00FF) << 8)) >>> 1;\n}\n// create huffman tree from u8 \"map\": index -> code length for code index\n// mb (max bits) must be at most 15\n// TODO: optimize/split up?\nvar hMap = (function (cd, mb, r) {\n    var s = cd.length;\n    // index\n    var i = 0;\n    // u16 \"map\": index -> # of codes with bit length = index\n    var l = new u16(mb);\n    // length of cd must be 288 (total # of codes)\n    for (; i < s; ++i) {\n        if (cd[i])\n            ++l[cd[i] - 1];\n    }\n    // u16 \"map\": index -> minimum code for bit length = index\n    var le = new u16(mb);\n    for (i = 0; i < mb; ++i) {\n        le[i] = (le[i - 1] + l[i - 1]) << 1;\n    }\n    var co;\n    if (r) {\n        // u16 \"map\": index -> number of actual bits, symbol for code\n        co = new u16(1 << mb);\n        // bits to remove for reverser\n        var rvb = 15 - mb;\n        for (i = 0; i < s; ++i) {\n            // ignore 0 lengths\n            if (cd[i]) {\n                // num encoding both symbol and bits read\n                var sv = (i << 4) | cd[i];\n                // free bits\n                var r_1 = mb - cd[i];\n                // start value\n                var v = le[cd[i] - 1]++ << r_1;\n                // m is end value\n                for (var m = v | ((1 << r_1) - 1); v <= m; ++v) {\n                    // every 16 bit value starting with the code yields the same result\n                    co[rev[v] >>> rvb] = sv;\n                }\n            }\n        }\n    }\n    else {\n        co = new u16(s);\n        for (i = 0; i < s; ++i) {\n            if (cd[i]) {\n                co[i] = rev[le[cd[i] - 1]++] >>> (15 - cd[i]);\n            }\n        }\n    }\n    return co;\n});\n// fixed length tree\nvar flt = new u8(288);\nfor (var i = 0; i < 144; ++i)\n    flt[i] = 8;\nfor (var i = 144; i < 256; ++i)\n    flt[i] = 9;\nfor (var i = 256; i < 280; ++i)\n    flt[i] = 7;\nfor (var i = 280; i < 288; ++i)\n    flt[i] = 8;\n// fixed distance tree\nvar fdt = new u8(32);\nfor (var i = 0; i < 32; ++i)\n    fdt[i] = 5;\n// fixed length map\nvar flm = /*#__PURE__*/ hMap(flt, 9, 0), flrm = /*#__PURE__*/ hMap(flt, 9, 1);\n// fixed distance map\nvar fdm = /*#__PURE__*/ hMap(fdt, 5, 0), fdrm = /*#__PURE__*/ hMap(fdt, 5, 1);\n// find max of array\nvar max = function (a) {\n    var m = a[0];\n    for (var i = 1; i < a.length; ++i) {\n        if (a[i] > m)\n            m = a[i];\n    }\n    return m;\n};\n// read d, starting at bit p and mask with m\nvar bits = function (d, p, m) {\n    var o = (p / 8) | 0;\n    return ((d[o] | (d[o + 1] << 8)) >> (p & 7)) & m;\n};\n// read d, starting at bit p continuing for at least 16 bits\nvar bits16 = function (d, p) {\n    var o = (p / 8) | 0;\n    return ((d[o] | (d[o + 1] << 8) | (d[o + 2] << 16)) >> (p & 7));\n};\n// get end of byte\nvar shft = function (p) { return ((p + 7) / 8) | 0; };\n// typed array slice - allows garbage collector to free original reference,\n// while being more compatible than .slice\nvar slc = function (v, s, e) {\n    if (s == null || s < 0)\n        s = 0;\n    if (e == null || e > v.length)\n        e = v.length;\n    // can't use .constructor in case user-supplied\n    var n = new (v.BYTES_PER_ELEMENT == 2 ? u16 : v.BYTES_PER_ELEMENT == 4 ? u32 : u8)(e - s);\n    n.set(v.subarray(s, e));\n    return n;\n};\n/**\n * Codes for errors generated within this library\n */\nexport var FlateErrorCode = {\n    UnexpectedEOF: 0,\n    InvalidBlockType: 1,\n    InvalidLengthLiteral: 2,\n    InvalidDistance: 3,\n    StreamFinished: 4,\n    NoStreamHandler: 5,\n    InvalidHeader: 6,\n    NoCallback: 7,\n    InvalidUTF8: 8,\n    ExtraFieldTooLong: 9,\n    InvalidDate: 10,\n    FilenameTooLong: 11,\n    StreamFinishing: 12,\n    InvalidZipData: 13,\n    UnknownCompressionMethod: 14\n};\n// error codes\nvar ec = [\n    'unexpected EOF',\n    'invalid block type',\n    'invalid length/literal',\n    'invalid distance',\n    'stream finished',\n    'no stream handler',\n    ,\n    'no callback',\n    'invalid UTF-8 data',\n    'extra field too long',\n    'date not in range 1980-2099',\n    'filename too long',\n    'stream finishing',\n    'invalid zip data'\n    // determined by unknown compression method\n];\n;\nvar err = function (ind, msg, nt) {\n    var e = new Error(msg || ec[ind]);\n    e.code = ind;\n    if (Error.captureStackTrace)\n        Error.captureStackTrace(e, err);\n    if (!nt)\n        throw e;\n    return e;\n};\n// expands raw DEFLATE data\nvar inflt = function (dat, buf, st) {\n    // source length\n    var sl = dat.length;\n    if (!sl || (st && st.f && !st.l))\n        return buf || new u8(0);\n    // have to estimate size\n    var noBuf = !buf || st;\n    // no state\n    var noSt = !st || st.i;\n    if (!st)\n        st = {};\n    // Assumes roughly 33% compression ratio average\n    if (!buf)\n        buf = new u8(sl * 3);\n    // ensure buffer can fit at least l elements\n    var cbuf = function (l) {\n        var bl = buf.length;\n        // need to increase size to fit\n        if (l > bl) {\n            // Double or set to necessary, whichever is greater\n            var nbuf = new u8(Math.max(bl * 2, l));\n            nbuf.set(buf);\n            buf = nbuf;\n        }\n    };\n    //  last chunk         bitpos           bytes\n    var final = st.f || 0, pos = st.p || 0, bt = st.b || 0, lm = st.l, dm = st.d, lbt = st.m, dbt = st.n;\n    // total bits\n    var tbts = sl * 8;\n    do {\n        if (!lm) {\n            // BFINAL - this is only 1 when last chunk is next\n            final = bits(dat, pos, 1);\n            // type: 0 = no compression, 1 = fixed huffman, 2 = dynamic huffman\n            var type = bits(dat, pos + 1, 3);\n            pos += 3;\n            if (!type) {\n                // go to end of byte boundary\n                var s = shft(pos) + 4, l = dat[s - 4] | (dat[s - 3] << 8), t = s + l;\n                if (t > sl) {\n                    if (noSt)\n                        err(0);\n                    break;\n                }\n                // ensure size\n                if (noBuf)\n                    cbuf(bt + l);\n                // Copy over uncompressed data\n                buf.set(dat.subarray(s, t), bt);\n                // Get new bitpos, update byte count\n                st.b = bt += l, st.p = pos = t * 8, st.f = final;\n                continue;\n            }\n            else if (type == 1)\n                lm = flrm, dm = fdrm, lbt = 9, dbt = 5;\n            else if (type == 2) {\n                //  literal                            lengths\n                var hLit = bits(dat, pos, 31) + 257, hcLen = bits(dat, pos + 10, 15) + 4;\n                var tl = hLit + bits(dat, pos + 5, 31) + 1;\n                pos += 14;\n                // length+distance tree\n                var ldt = new u8(tl);\n                // code length tree\n                var clt = new u8(19);\n                for (var i = 0; i < hcLen; ++i) {\n                    // use index map to get real code\n                    clt[clim[i]] = bits(dat, pos + i * 3, 7);\n                }\n                pos += hcLen * 3;\n                // code lengths bits\n                var clb = max(clt), clbmsk = (1 << clb) - 1;\n                // code lengths map\n                var clm = hMap(clt, clb, 1);\n                for (var i = 0; i < tl;) {\n                    var r = clm[bits(dat, pos, clbmsk)];\n                    // bits read\n                    pos += r & 15;\n                    // symbol\n                    var s = r >>> 4;\n                    // code length to copy\n                    if (s < 16) {\n                        ldt[i++] = s;\n                    }\n                    else {\n                        //  copy   count\n                        var c = 0, n = 0;\n                        if (s == 16)\n                            n = 3 + bits(dat, pos, 3), pos += 2, c = ldt[i - 1];\n                        else if (s == 17)\n                            n = 3 + bits(dat, pos, 7), pos += 3;\n                        else if (s == 18)\n                            n = 11 + bits(dat, pos, 127), pos += 7;\n                        while (n--)\n                            ldt[i++] = c;\n                    }\n                }\n                //    length tree                 distance tree\n                var lt = ldt.subarray(0, hLit), dt = ldt.subarray(hLit);\n                // max length bits\n                lbt = max(lt);\n                // max dist bits\n                dbt = max(dt);\n                lm = hMap(lt, lbt, 1);\n                dm = hMap(dt, dbt, 1);\n            }\n            else\n                err(1);\n            if (pos > tbts) {\n                if (noSt)\n                    err(0);\n                break;\n            }\n        }\n        // Make sure the buffer can hold this + the largest possible addition\n        // Maximum chunk size (practically, theoretically infinite) is 2^17;\n        if (noBuf)\n            cbuf(bt + 131072);\n        var lms = (1 << lbt) - 1, dms = (1 << dbt) - 1;\n        var lpos = pos;\n        for (;; lpos = pos) {\n            // bits read, code\n            var c = lm[bits16(dat, pos) & lms], sym = c >>> 4;\n            pos += c & 15;\n            if (pos > tbts) {\n                if (noSt)\n                    err(0);\n                break;\n            }\n            if (!c)\n                err(2);\n            if (sym < 256)\n                buf[bt++] = sym;\n            else if (sym == 256) {\n                lpos = pos, lm = null;\n                break;\n            }\n            else {\n                var add = sym - 254;\n                // no extra bits needed if less\n                if (sym > 264) {\n                    // index\n                    var i = sym - 257, b = fleb[i];\n                    add = bits(dat, pos, (1 << b) - 1) + fl[i];\n                    pos += b;\n                }\n                // dist\n                var d = dm[bits16(dat, pos) & dms], dsym = d >>> 4;\n                if (!d)\n                    err(3);\n                pos += d & 15;\n                var dt = fd[dsym];\n                if (dsym > 3) {\n                    var b = fdeb[dsym];\n                    dt += bits16(dat, pos) & ((1 << b) - 1), pos += b;\n                }\n                if (pos > tbts) {\n                    if (noSt)\n                        err(0);\n                    break;\n                }\n                if (noBuf)\n                    cbuf(bt + 131072);\n                var end = bt + add;\n                for (; bt < end; bt += 4) {\n                    buf[bt] = buf[bt - dt];\n                    buf[bt + 1] = buf[bt + 1 - dt];\n                    buf[bt + 2] = buf[bt + 2 - dt];\n                    buf[bt + 3] = buf[bt + 3 - dt];\n                }\n                bt = end;\n            }\n        }\n        st.l = lm, st.p = lpos, st.b = bt, st.f = final;\n        if (lm)\n            final = 1, st.m = lbt, st.d = dm, st.n = dbt;\n    } while (!final);\n    return bt == buf.length ? buf : slc(buf, 0, bt);\n};\n// starting at p, write the minimum number of bits that can hold v to d\nvar wbits = function (d, p, v) {\n    v <<= p & 7;\n    var o = (p / 8) | 0;\n    d[o] |= v;\n    d[o + 1] |= v >>> 8;\n};\n// starting at p, write the minimum number of bits (>8) that can hold v to d\nvar wbits16 = function (d, p, v) {\n    v <<= p & 7;\n    var o = (p / 8) | 0;\n    d[o] |= v;\n    d[o + 1] |= v >>> 8;\n    d[o + 2] |= v >>> 16;\n};\n// creates code lengths from a frequency table\nvar hTree = function (d, mb) {\n    // Need extra info to make a tree\n    var t = [];\n    for (var i = 0; i < d.length; ++i) {\n        if (d[i])\n            t.push({ s: i, f: d[i] });\n    }\n    var s = t.length;\n    var t2 = t.slice();\n    if (!s)\n        return [et, 0];\n    if (s == 1) {\n        var v = new u8(t[0].s + 1);\n        v[t[0].s] = 1;\n        return [v, 1];\n    }\n    t.sort(function (a, b) { return a.f - b.f; });\n    // after i2 reaches last ind, will be stopped\n    // freq must be greater than largest possible number of symbols\n    t.push({ s: -1, f: 25001 });\n    var l = t[0], r = t[1], i0 = 0, i1 = 1, i2 = 2;\n    t[0] = { s: -1, f: l.f + r.f, l: l, r: r };\n    // efficient algorithm from UZIP.js\n    // i0 is lookbehind, i2 is lookahead - after processing two low-freq\n    // symbols that combined have high freq, will start processing i2 (high-freq,\n    // non-composite) symbols instead\n    // see https://reddit.com/r/photopea/comments/ikekht/uzipjs_questions/\n    while (i1 != s - 1) {\n        l = t[t[i0].f < t[i2].f ? i0++ : i2++];\n        r = t[i0 != i1 && t[i0].f < t[i2].f ? i0++ : i2++];\n        t[i1++] = { s: -1, f: l.f + r.f, l: l, r: r };\n    }\n    var maxSym = t2[0].s;\n    for (var i = 1; i < s; ++i) {\n        if (t2[i].s > maxSym)\n            maxSym = t2[i].s;\n    }\n    // code lengths\n    var tr = new u16(maxSym + 1);\n    // max bits in tree\n    var mbt = ln(t[i1 - 1], tr, 0);\n    if (mbt > mb) {\n        // more algorithms from UZIP.js\n        // TODO: find out how this code works (debt)\n        //  ind    debt\n        var i = 0, dt = 0;\n        //    left            cost\n        var lft = mbt - mb, cst = 1 << lft;\n        t2.sort(function (a, b) { return tr[b.s] - tr[a.s] || a.f - b.f; });\n        for (; i < s; ++i) {\n            var i2_1 = t2[i].s;\n            if (tr[i2_1] > mb) {\n                dt += cst - (1 << (mbt - tr[i2_1]));\n                tr[i2_1] = mb;\n            }\n            else\n                break;\n        }\n        dt >>>= lft;\n        while (dt > 0) {\n            var i2_2 = t2[i].s;\n            if (tr[i2_2] < mb)\n                dt -= 1 << (mb - tr[i2_2]++ - 1);\n            else\n                ++i;\n        }\n        for (; i >= 0 && dt; --i) {\n            var i2_3 = t2[i].s;\n            if (tr[i2_3] == mb) {\n                --tr[i2_3];\n                ++dt;\n            }\n        }\n        mbt = mb;\n    }\n    return [new u8(tr), mbt];\n};\n// get the max length and assign length codes\nvar ln = function (n, l, d) {\n    return n.s == -1\n        ? Math.max(ln(n.l, l, d + 1), ln(n.r, l, d + 1))\n        : (l[n.s] = d);\n};\n// length codes generation\nvar lc = function (c) {\n    var s = c.length;\n    // Note that the semicolon was intentional\n    while (s && !c[--s])\n        ;\n    var cl = new u16(++s);\n    //  ind      num         streak\n    var cli = 0, cln = c[0], cls = 1;\n    var w = function (v) { cl[cli++] = v; };\n    for (var i = 1; i <= s; ++i) {\n        if (c[i] == cln && i != s)\n            ++cls;\n        else {\n            if (!cln && cls > 2) {\n                for (; cls > 138; cls -= 138)\n                    w(32754);\n                if (cls > 2) {\n                    w(cls > 10 ? ((cls - 11) << 5) | 28690 : ((cls - 3) << 5) | 12305);\n                    cls = 0;\n                }\n            }\n            else if (cls > 3) {\n                w(cln), --cls;\n                for (; cls > 6; cls -= 6)\n                    w(8304);\n                if (cls > 2)\n                    w(((cls - 3) << 5) | 8208), cls = 0;\n            }\n            while (cls--)\n                w(cln);\n            cls = 1;\n            cln = c[i];\n        }\n    }\n    return [cl.subarray(0, cli), s];\n};\n// calculate the length of output from tree, code lengths\nvar clen = function (cf, cl) {\n    var l = 0;\n    for (var i = 0; i < cl.length; ++i)\n        l += cf[i] * cl[i];\n    return l;\n};\n// writes a fixed block\n// returns the new bit pos\nvar wfblk = function (out, pos, dat) {\n    // no need to write 00 as type: TypedArray defaults to 0\n    var s = dat.length;\n    var o = shft(pos + 2);\n    out[o] = s & 255;\n    out[o + 1] = s >>> 8;\n    out[o + 2] = out[o] ^ 255;\n    out[o + 3] = out[o + 1] ^ 255;\n    for (var i = 0; i < s; ++i)\n        out[o + i + 4] = dat[i];\n    return (o + 4 + s) * 8;\n};\n// writes a block\nvar wblk = function (dat, out, final, syms, lf, df, eb, li, bs, bl, p) {\n    wbits(out, p++, final);\n    ++lf[256];\n    var _a = hTree(lf, 15), dlt = _a[0], mlb = _a[1];\n    var _b = hTree(df, 15), ddt = _b[0], mdb = _b[1];\n    var _c = lc(dlt), lclt = _c[0], nlc = _c[1];\n    var _d = lc(ddt), lcdt = _d[0], ndc = _d[1];\n    var lcfreq = new u16(19);\n    for (var i = 0; i < lclt.length; ++i)\n        lcfreq[lclt[i] & 31]++;\n    for (var i = 0; i < lcdt.length; ++i)\n        lcfreq[lcdt[i] & 31]++;\n    var _e = hTree(lcfreq, 7), lct = _e[0], mlcb = _e[1];\n    var nlcc = 19;\n    for (; nlcc > 4 && !lct[clim[nlcc - 1]]; --nlcc)\n        ;\n    var flen = (bl + 5) << 3;\n    var ftlen = clen(lf, flt) + clen(df, fdt) + eb;\n    var dtlen = clen(lf, dlt) + clen(df, ddt) + eb + 14 + 3 * nlcc + clen(lcfreq, lct) + (2 * lcfreq[16] + 3 * lcfreq[17] + 7 * lcfreq[18]);\n    if (flen <= ftlen && flen <= dtlen)\n        return wfblk(out, p, dat.subarray(bs, bs + bl));\n    var lm, ll, dm, dl;\n    wbits(out, p, 1 + (dtlen < ftlen)), p += 2;\n    if (dtlen < ftlen) {\n        lm = hMap(dlt, mlb, 0), ll = dlt, dm = hMap(ddt, mdb, 0), dl = ddt;\n        var llm = hMap(lct, mlcb, 0);\n        wbits(out, p, nlc - 257);\n        wbits(out, p + 5, ndc - 1);\n        wbits(out, p + 10, nlcc - 4);\n        p += 14;\n        for (var i = 0; i < nlcc; ++i)\n            wbits(out, p + 3 * i, lct[clim[i]]);\n        p += 3 * nlcc;\n        var lcts = [lclt, lcdt];\n        for (var it = 0; it < 2; ++it) {\n            var clct = lcts[it];\n            for (var i = 0; i < clct.length; ++i) {\n                var len = clct[i] & 31;\n                wbits(out, p, llm[len]), p += lct[len];\n                if (len > 15)\n                    wbits(out, p, (clct[i] >>> 5) & 127), p += clct[i] >>> 12;\n            }\n        }\n    }\n    else {\n        lm = flm, ll = flt, dm = fdm, dl = fdt;\n    }\n    for (var i = 0; i < li; ++i) {\n        if (syms[i] > 255) {\n            var len = (syms[i] >>> 18) & 31;\n            wbits16(out, p, lm[len + 257]), p += ll[len + 257];\n            if (len > 7)\n                wbits(out, p, (syms[i] >>> 23) & 31), p += fleb[len];\n            var dst = syms[i] & 31;\n            wbits16(out, p, dm[dst]), p += dl[dst];\n            if (dst > 3)\n                wbits16(out, p, (syms[i] >>> 5) & 8191), p += fdeb[dst];\n        }\n        else {\n            wbits16(out, p, lm[syms[i]]), p += ll[syms[i]];\n        }\n    }\n    wbits16(out, p, lm[256]);\n    return p + ll[256];\n};\n// deflate options (nice << 13) | chain\nvar deo = /*#__PURE__*/ new u32([65540, 131080, 131088, 131104, 262176, 1048704, 1048832, 2114560, 2117632]);\n// empty\nvar et = /*#__PURE__*/ new u8(0);\n// compresses data into a raw DEFLATE buffer\nvar dflt = function (dat, lvl, plvl, pre, post, lst) {\n    var s = dat.length;\n    var o = new u8(pre + s + 5 * (1 + Math.ceil(s / 7000)) + post);\n    // writing to this writes to the output buffer\n    var w = o.subarray(pre, o.length - post);\n    var pos = 0;\n    if (!lvl || s < 8) {\n        for (var i = 0; i <= s; i += 65535) {\n            // end\n            var e = i + 65535;\n            if (e >= s) {\n                // write final block\n                w[pos >> 3] = lst;\n            }\n            pos = wfblk(w, pos + 1, dat.subarray(i, e));\n        }\n    }\n    else {\n        var opt = deo[lvl - 1];\n        var n = opt >>> 13, c = opt & 8191;\n        var msk_1 = (1 << plvl) - 1;\n        //    prev 2-byte val map    curr 2-byte val map\n        var prev = new u16(32768), head = new u16(msk_1 + 1);\n        var bs1_1 = Math.ceil(plvl / 3), bs2_1 = 2 * bs1_1;\n        var hsh = function (i) { return (dat[i] ^ (dat[i + 1] << bs1_1) ^ (dat[i + 2] << bs2_1)) & msk_1; };\n        // 24576 is an arbitrary number of maximum symbols per block\n        // 424 buffer for last block\n        var syms = new u32(25000);\n        // length/literal freq   distance freq\n        var lf = new u16(288), df = new u16(32);\n        //  l/lcnt  exbits  index  l/lind  waitdx  bitpos\n        var lc_1 = 0, eb = 0, i = 0, li = 0, wi = 0, bs = 0;\n        for (; i < s; ++i) {\n            // hash value\n            // deopt when i > s - 3 - at end, deopt acceptable\n            var hv = hsh(i);\n            // index mod 32768    previous index mod\n            var imod = i & 32767, pimod = head[hv];\n            prev[imod] = pimod;\n            head[hv] = imod;\n            // We always should modify head and prev, but only add symbols if\n            // this data is not yet processed (\"wait\" for wait index)\n            if (wi <= i) {\n                // bytes remaining\n                var rem = s - i;\n                if ((lc_1 > 7000 || li > 24576) && rem > 423) {\n                    pos = wblk(dat, w, 0, syms, lf, df, eb, li, bs, i - bs, pos);\n                    li = lc_1 = eb = 0, bs = i;\n                    for (var j = 0; j < 286; ++j)\n                        lf[j] = 0;\n                    for (var j = 0; j < 30; ++j)\n                        df[j] = 0;\n                }\n                //  len    dist   chain\n                var l = 2, d = 0, ch_1 = c, dif = (imod - pimod) & 32767;\n                if (rem > 2 && hv == hsh(i - dif)) {\n                    var maxn = Math.min(n, rem) - 1;\n                    var maxd = Math.min(32767, i);\n                    // max possible length\n                    // not capped at dif because decompressors implement \"rolling\" index population\n                    var ml = Math.min(258, rem);\n                    while (dif <= maxd && --ch_1 && imod != pimod) {\n                        if (dat[i + l] == dat[i + l - dif]) {\n                            var nl = 0;\n                            for (; nl < ml && dat[i + nl] == dat[i + nl - dif]; ++nl)\n                                ;\n                            if (nl > l) {\n                                l = nl, d = dif;\n                                // break out early when we reach \"nice\" (we are satisfied enough)\n                                if (nl > maxn)\n                                    break;\n                                // now, find the rarest 2-byte sequence within this\n                                // length of literals and search for that instead.\n                                // Much faster than just using the start\n                                var mmd = Math.min(dif, nl - 2);\n                                var md = 0;\n                                for (var j = 0; j < mmd; ++j) {\n                                    var ti = (i - dif + j + 32768) & 32767;\n                                    var pti = prev[ti];\n                                    var cd = (ti - pti + 32768) & 32767;\n                                    if (cd > md)\n                                        md = cd, pimod = ti;\n                                }\n                            }\n                        }\n                        // check the previous match\n                        imod = pimod, pimod = prev[imod];\n                        dif += (imod - pimod + 32768) & 32767;\n                    }\n                }\n                // d will be nonzero only when a match was found\n                if (d) {\n                    // store both dist and len data in one Uint32\n                    // Make sure this is recognized as a len/dist with 28th bit (2^28)\n                    syms[li++] = 268435456 | (revfl[l] << 18) | revfd[d];\n                    var lin = revfl[l] & 31, din = revfd[d] & 31;\n                    eb += fleb[lin] + fdeb[din];\n                    ++lf[257 + lin];\n                    ++df[din];\n                    wi = i + l;\n                    ++lc_1;\n                }\n                else {\n                    syms[li++] = dat[i];\n                    ++lf[dat[i]];\n                }\n            }\n        }\n        pos = wblk(dat, w, lst, syms, lf, df, eb, li, bs, i - bs, pos);\n        // this is the easiest way to avoid needing to maintain state\n        if (!lst && pos & 7)\n            pos = wfblk(w, pos + 1, et);\n    }\n    return slc(o, 0, pre + shft(pos) + post);\n};\n// CRC32 table\nvar crct = /*#__PURE__*/ (function () {\n    var t = new Int32Array(256);\n    for (var i = 0; i < 256; ++i) {\n        var c = i, k = 9;\n        while (--k)\n            c = ((c & 1) && -306674912) ^ (c >>> 1);\n        t[i] = c;\n    }\n    return t;\n})();\n// CRC32\nvar crc = function () {\n    var c = -1;\n    return {\n        p: function (d) {\n            // closures have awful performance\n            var cr = c;\n            for (var i = 0; i < d.length; ++i)\n                cr = crct[(cr & 255) ^ d[i]] ^ (cr >>> 8);\n            c = cr;\n        },\n        d: function () { return ~c; }\n    };\n};\n// Alder32\nvar adler = function () {\n    var a = 1, b = 0;\n    return {\n        p: function (d) {\n            // closures have awful performance\n            var n = a, m = b;\n            var l = d.length | 0;\n            for (var i = 0; i != l;) {\n                var e = Math.min(i + 2655, l);\n                for (; i < e; ++i)\n                    m += n += d[i];\n                n = (n & 65535) + 15 * (n >> 16), m = (m & 65535) + 15 * (m >> 16);\n            }\n            a = n, b = m;\n        },\n        d: function () {\n            a %= 65521, b %= 65521;\n            return (a & 255) << 24 | (a >>> 8) << 16 | (b & 255) << 8 | (b >>> 8);\n        }\n    };\n};\n;\n// deflate with opts\nvar dopt = function (dat, opt, pre, post, st) {\n    return dflt(dat, opt.level == null ? 6 : opt.level, opt.mem == null ? Math.ceil(Math.max(8, Math.min(13, Math.log(dat.length))) * 1.5) : (12 + opt.mem), pre, post, !st);\n};\n// Walmart object spread\nvar mrg = function (a, b) {\n    var o = {};\n    for (var k in a)\n        o[k] = a[k];\n    for (var k in b)\n        o[k] = b[k];\n    return o;\n};\n// worker clone\n// This is possibly the craziest part of the entire codebase, despite how simple it may seem.\n// The only parameter to this function is a closure that returns an array of variables outside of the function scope.\n// We're going to try to figure out the variable names used in the closure as strings because that is crucial for workerization.\n// We will return an object mapping of true variable name to value (basically, the current scope as a JS object).\n// The reason we can't just use the original variable names is minifiers mangling the toplevel scope.\n// This took me three weeks to figure out how to do.\nvar wcln = function (fn, fnStr, td) {\n    var dt = fn();\n    var st = fn.toString();\n    var ks = st.slice(st.indexOf('[') + 1, st.lastIndexOf(']')).replace(/\\s+/g, '').split(',');\n    for (var i = 0; i < dt.length; ++i) {\n        var v = dt[i], k = ks[i];\n        if (typeof v == 'function') {\n            fnStr += ';' + k + '=';\n            var st_1 = v.toString();\n            if (v.prototype) {\n                // for global objects\n                if (st_1.indexOf('[native code]') != -1) {\n                    var spInd = st_1.indexOf(' ', 8) + 1;\n                    fnStr += st_1.slice(spInd, st_1.indexOf('(', spInd));\n                }\n                else {\n                    fnStr += st_1;\n                    for (var t in v.prototype)\n                        fnStr += ';' + k + '.prototype.' + t + '=' + v.prototype[t].toString();\n                }\n            }\n            else\n                fnStr += st_1;\n        }\n        else\n            td[k] = v;\n    }\n    return [fnStr, td];\n};\nvar ch = [];\n// clone bufs\nvar cbfs = function (v) {\n    var tl = [];\n    for (var k in v) {\n        if (v[k].buffer) {\n            tl.push((v[k] = new v[k].constructor(v[k])).buffer);\n        }\n    }\n    return tl;\n};\n// use a worker to execute code\nvar wrkr = function (fns, init, id, cb) {\n    var _a;\n    if (!ch[id]) {\n        var fnStr = '', td_1 = {}, m = fns.length - 1;\n        for (var i = 0; i < m; ++i)\n            _a = wcln(fns[i], fnStr, td_1), fnStr = _a[0], td_1 = _a[1];\n        ch[id] = wcln(fns[m], fnStr, td_1);\n    }\n    var td = mrg({}, ch[id][1]);\n    return wk(ch[id][0] + ';onmessage=function(e){for(var k in e.data)self[k]=e.data[k];onmessage=' + init.toString() + '}', id, td, cbfs(td), cb);\n};\n// base async inflate fn\nvar bInflt = function () { return [u8, u16, u32, fleb, fdeb, clim, fl, fd, flrm, fdrm, rev, ec, hMap, max, bits, bits16, shft, slc, err, inflt, inflateSync, pbf, gu8]; };\nvar bDflt = function () { return [u8, u16, u32, fleb, fdeb, clim, revfl, revfd, flm, flt, fdm, fdt, rev, deo, et, hMap, wbits, wbits16, hTree, ln, lc, clen, wfblk, wblk, shft, slc, dflt, dopt, deflateSync, pbf]; };\n// gzip extra\nvar gze = function () { return [gzh, gzhl, wbytes, crc, crct]; };\n// gunzip extra\nvar guze = function () { return [gzs, gzl]; };\n// zlib extra\nvar zle = function () { return [zlh, wbytes, adler]; };\n// unzlib extra\nvar zule = function () { return [zlv]; };\n// post buf\nvar pbf = function (msg) { return postMessage(msg, [msg.buffer]); };\n// get u8\nvar gu8 = function (o) { return o && o.size && new u8(o.size); };\n// async helper\nvar cbify = function (dat, opts, fns, init, id, cb) {\n    var w = wrkr(fns, init, id, function (err, dat) {\n        w.terminate();\n        cb(err, dat);\n    });\n    w.postMessage([dat, opts], opts.consume ? [dat.buffer] : []);\n    return function () { w.terminate(); };\n};\n// auto stream\nvar astrm = function (strm) {\n    strm.ondata = function (dat, final) { return postMessage([dat, final], [dat.buffer]); };\n    return function (ev) { return strm.push(ev.data[0], ev.data[1]); };\n};\n// async stream attach\nvar astrmify = function (fns, strm, opts, init, id) {\n    var t;\n    var w = wrkr(fns, init, id, function (err, dat) {\n        if (err)\n            w.terminate(), strm.ondata.call(strm, err);\n        else {\n            if (dat[1])\n                w.terminate();\n            strm.ondata.call(strm, err, dat[0], dat[1]);\n        }\n    });\n    w.postMessage(opts);\n    strm.push = function (d, f) {\n        if (!strm.ondata)\n            err(5);\n        if (t)\n            strm.ondata(err(4, 0, 1), null, !!f);\n        w.postMessage([d, t = f], [d.buffer]);\n    };\n    strm.terminate = function () { w.terminate(); };\n};\n// read 2 bytes\nvar b2 = function (d, b) { return d[b] | (d[b + 1] << 8); };\n// read 4 bytes\nvar b4 = function (d, b) { return (d[b] | (d[b + 1] << 8) | (d[b + 2] << 16) | (d[b + 3] << 24)) >>> 0; };\nvar b8 = function (d, b) { return b4(d, b) + (b4(d, b + 4) * 4294967296); };\n// write bytes\nvar wbytes = function (d, b, v) {\n    for (; v; ++b)\n        d[b] = v, v >>>= 8;\n};\n// gzip header\nvar gzh = function (c, o) {\n    var fn = o.filename;\n    c[0] = 31, c[1] = 139, c[2] = 8, c[8] = o.level < 2 ? 4 : o.level == 9 ? 2 : 0, c[9] = 3; // assume Unix\n    if (o.mtime != 0)\n        wbytes(c, 4, Math.floor(new Date(o.mtime || Date.now()) / 1000));\n    if (fn) {\n        c[3] = 8;\n        for (var i = 0; i <= fn.length; ++i)\n            c[i + 10] = fn.charCodeAt(i);\n    }\n};\n// gzip footer: -8 to -4 = CRC, -4 to -0 is length\n// gzip start\nvar gzs = function (d) {\n    if (d[0] != 31 || d[1] != 139 || d[2] != 8)\n        err(6, 'invalid gzip data');\n    var flg = d[3];\n    var st = 10;\n    if (flg & 4)\n        st += d[10] | (d[11] << 8) + 2;\n    for (var zs = (flg >> 3 & 1) + (flg >> 4 & 1); zs > 0; zs -= !d[st++])\n        ;\n    return st + (flg & 2);\n};\n// gzip length\nvar gzl = function (d) {\n    var l = d.length;\n    return ((d[l - 4] | d[l - 3] << 8 | d[l - 2] << 16) | (d[l - 1] << 24)) >>> 0;\n};\n// gzip header length\nvar gzhl = function (o) { return 10 + ((o.filename && (o.filename.length + 1)) || 0); };\n// zlib header\nvar zlh = function (c, o) {\n    var lv = o.level, fl = lv == 0 ? 0 : lv < 6 ? 1 : lv == 9 ? 3 : 2;\n    c[0] = 120, c[1] = (fl << 6) | (fl ? (32 - 2 * fl) : 1);\n};\n// zlib valid\nvar zlv = function (d) {\n    if ((d[0] & 15) != 8 || (d[0] >>> 4) > 7 || ((d[0] << 8 | d[1]) % 31))\n        err(6, 'invalid zlib data');\n    if (d[1] & 32)\n        err(6, 'invalid zlib data: preset dictionaries not supported');\n};\nfunction AsyncCmpStrm(opts, cb) {\n    if (!cb && typeof opts == 'function')\n        cb = opts, opts = {};\n    this.ondata = cb;\n    return opts;\n}\n// zlib footer: -4 to -0 is Adler32\n/**\n * Streaming DEFLATE compression\n */\nvar Deflate = /*#__PURE__*/ (function () {\n    function Deflate(opts, cb) {\n        if (!cb && typeof opts == 'function')\n            cb = opts, opts = {};\n        this.ondata = cb;\n        this.o = opts || {};\n    }\n    Deflate.prototype.p = function (c, f) {\n        this.ondata(dopt(c, this.o, 0, 0, !f), f);\n    };\n    /**\n     * Pushes a chunk to be deflated\n     * @param chunk The chunk to push\n     * @param final Whether this is the last chunk\n     */\n    Deflate.prototype.push = function (chunk, final) {\n        if (!this.ondata)\n            err(5);\n        if (this.d)\n            err(4);\n        this.d = final;\n        this.p(chunk, final || false);\n    };\n    return Deflate;\n}());\nexport { Deflate };\n/**\n * Asynchronous streaming DEFLATE compression\n */\nvar AsyncDeflate = /*#__PURE__*/ (function () {\n    function AsyncDeflate(opts, cb) {\n        astrmify([\n            bDflt,\n            function () { return [astrm, Deflate]; }\n        ], this, AsyncCmpStrm.call(this, opts, cb), function (ev) {\n            var strm = new Deflate(ev.data);\n            onmessage = astrm(strm);\n        }, 6);\n    }\n    return AsyncDeflate;\n}());\nexport { AsyncDeflate };\nexport function deflate(data, opts, cb) {\n    if (!cb)\n        cb = opts, opts = {};\n    if (typeof cb != 'function')\n        err(7);\n    return cbify(data, opts, [\n        bDflt,\n    ], function (ev) { return pbf(deflateSync(ev.data[0], ev.data[1])); }, 0, cb);\n}\n/**\n * Compresses data with DEFLATE without any wrapper\n * @param data The data to compress\n * @param opts The compression options\n * @returns The deflated version of the data\n */\nexport function deflateSync(data, opts) {\n    return dopt(data, opts || {}, 0, 0);\n}\n/**\n * Streaming DEFLATE decompression\n */\nvar Inflate = /*#__PURE__*/ (function () {\n    /**\n     * Creates an inflation stream\n     * @param cb The callback to call whenever data is inflated\n     */\n    function Inflate(cb) {\n        this.s = {};\n        this.p = new u8(0);\n        this.ondata = cb;\n    }\n    Inflate.prototype.e = function (c) {\n        if (!this.ondata)\n            err(5);\n        if (this.d)\n            err(4);\n        var l = this.p.length;\n        var n = new u8(l + c.length);\n        n.set(this.p), n.set(c, l), this.p = n;\n    };\n    Inflate.prototype.c = function (final) {\n        this.d = this.s.i = final || false;\n        var bts = this.s.b;\n        var dt = inflt(this.p, this.o, this.s);\n        this.ondata(slc(dt, bts, this.s.b), this.d);\n        this.o = slc(dt, this.s.b - 32768), this.s.b = this.o.length;\n        this.p = slc(this.p, (this.s.p / 8) | 0), this.s.p &= 7;\n    };\n    /**\n     * Pushes a chunk to be inflated\n     * @param chunk The chunk to push\n     * @param final Whether this is the final chunk\n     */\n    Inflate.prototype.push = function (chunk, final) {\n        this.e(chunk), this.c(final);\n    };\n    return Inflate;\n}());\nexport { Inflate };\n/**\n * Asynchronous streaming DEFLATE decompression\n */\nvar AsyncInflate = /*#__PURE__*/ (function () {\n    /**\n     * Creates an asynchronous inflation stream\n     * @param cb The callback to call whenever data is deflated\n     */\n    function AsyncInflate(cb) {\n        this.ondata = cb;\n        astrmify([\n            bInflt,\n            function () { return [astrm, Inflate]; }\n        ], this, 0, function () {\n            var strm = new Inflate();\n            onmessage = astrm(strm);\n        }, 7);\n    }\n    return AsyncInflate;\n}());\nexport { AsyncInflate };\nexport function inflate(data, opts, cb) {\n    if (!cb)\n        cb = opts, opts = {};\n    if (typeof cb != 'function')\n        err(7);\n    return cbify(data, opts, [\n        bInflt\n    ], function (ev) { return pbf(inflateSync(ev.data[0], gu8(ev.data[1]))); }, 1, cb);\n}\n/**\n * Expands DEFLATE data with no wrapper\n * @param data The data to decompress\n * @param out Where to write the data. Saves memory if you know the decompressed size and provide an output buffer of that length.\n * @returns The decompressed version of the data\n */\nexport function inflateSync(data, out) {\n    return inflt(data, out);\n}\n// before you yell at me for not just using extends, my reason is that TS inheritance is hard to workerize.\n/**\n * Streaming GZIP compression\n */\nvar Gzip = /*#__PURE__*/ (function () {\n    function Gzip(opts, cb) {\n        this.c = crc();\n        this.l = 0;\n        this.v = 1;\n        Deflate.call(this, opts, cb);\n    }\n    /**\n     * Pushes a chunk to be GZIPped\n     * @param chunk The chunk to push\n     * @param final Whether this is the last chunk\n     */\n    Gzip.prototype.push = function (chunk, final) {\n        Deflate.prototype.push.call(this, chunk, final);\n    };\n    Gzip.prototype.p = function (c, f) {\n        this.c.p(c);\n        this.l += c.length;\n        var raw = dopt(c, this.o, this.v && gzhl(this.o), f && 8, !f);\n        if (this.v)\n            gzh(raw, this.o), this.v = 0;\n        if (f)\n            wbytes(raw, raw.length - 8, this.c.d()), wbytes(raw, raw.length - 4, this.l);\n        this.ondata(raw, f);\n    };\n    return Gzip;\n}());\nexport { Gzip };\n/**\n * Asynchronous streaming GZIP compression\n */\nvar AsyncGzip = /*#__PURE__*/ (function () {\n    function AsyncGzip(opts, cb) {\n        astrmify([\n            bDflt,\n            gze,\n            function () { return [astrm, Deflate, Gzip]; }\n        ], this, AsyncCmpStrm.call(this, opts, cb), function (ev) {\n            var strm = new Gzip(ev.data);\n            onmessage = astrm(strm);\n        }, 8);\n    }\n    return AsyncGzip;\n}());\nexport { AsyncGzip };\nexport function gzip(data, opts, cb) {\n    if (!cb)\n        cb = opts, opts = {};\n    if (typeof cb != 'function')\n        err(7);\n    return cbify(data, opts, [\n        bDflt,\n        gze,\n        function () { return [gzipSync]; }\n    ], function (ev) { return pbf(gzipSync(ev.data[0], ev.data[1])); }, 2, cb);\n}\n/**\n * Compresses data with GZIP\n * @param data The data to compress\n * @param opts The compression options\n * @returns The gzipped version of the data\n */\nexport function gzipSync(data, opts) {\n    if (!opts)\n        opts = {};\n    var c = crc(), l = data.length;\n    c.p(data);\n    var d = dopt(data, opts, gzhl(opts), 8), s = d.length;\n    return gzh(d, opts), wbytes(d, s - 8, c.d()), wbytes(d, s - 4, l), d;\n}\n/**\n * Streaming GZIP decompression\n */\nvar Gunzip = /*#__PURE__*/ (function () {\n    /**\n     * Creates a GUNZIP stream\n     * @param cb The callback to call whenever data is inflated\n     */\n    function Gunzip(cb) {\n        this.v = 1;\n        Inflate.call(this, cb);\n    }\n    /**\n     * Pushes a chunk to be GUNZIPped\n     * @param chunk The chunk to push\n     * @param final Whether this is the last chunk\n     */\n    Gunzip.prototype.push = function (chunk, final) {\n        Inflate.prototype.e.call(this, chunk);\n        if (this.v) {\n            var s = this.p.length > 3 ? gzs(this.p) : 4;\n            if (s >= this.p.length && !final)\n                return;\n            this.p = this.p.subarray(s), this.v = 0;\n        }\n        if (final) {\n            if (this.p.length < 8)\n                err(6, 'invalid gzip data');\n            this.p = this.p.subarray(0, -8);\n        }\n        // necessary to prevent TS from using the closure value\n        // This allows for workerization to function correctly\n        Inflate.prototype.c.call(this, final);\n    };\n    return Gunzip;\n}());\nexport { Gunzip };\n/**\n * Asynchronous streaming GZIP decompression\n */\nvar AsyncGunzip = /*#__PURE__*/ (function () {\n    /**\n     * Creates an asynchronous GUNZIP stream\n     * @param cb The callback to call whenever data is deflated\n     */\n    function AsyncGunzip(cb) {\n        this.ondata = cb;\n        astrmify([\n            bInflt,\n            guze,\n            function () { return [astrm, Inflate, Gunzip]; }\n        ], this, 0, function () {\n            var strm = new Gunzip();\n            onmessage = astrm(strm);\n        }, 9);\n    }\n    return AsyncGunzip;\n}());\nexport { AsyncGunzip };\nexport function gunzip(data, opts, cb) {\n    if (!cb)\n        cb = opts, opts = {};\n    if (typeof cb != 'function')\n        err(7);\n    return cbify(data, opts, [\n        bInflt,\n        guze,\n        function () { return [gunzipSync]; }\n    ], function (ev) { return pbf(gunzipSync(ev.data[0])); }, 3, cb);\n}\n/**\n * Expands GZIP data\n * @param data The data to decompress\n * @param out Where to write the data. GZIP already encodes the output size, so providing this doesn't save memory.\n * @returns The decompressed version of the data\n */\nexport function gunzipSync(data, out) {\n    return inflt(data.subarray(gzs(data), -8), out || new u8(gzl(data)));\n}\n/**\n * Streaming Zlib compression\n */\nvar Zlib = /*#__PURE__*/ (function () {\n    function Zlib(opts, cb) {\n        this.c = adler();\n        this.v = 1;\n        Deflate.call(this, opts, cb);\n    }\n    /**\n     * Pushes a chunk to be zlibbed\n     * @param chunk The chunk to push\n     * @param final Whether this is the last chunk\n     */\n    Zlib.prototype.push = function (chunk, final) {\n        Deflate.prototype.push.call(this, chunk, final);\n    };\n    Zlib.prototype.p = function (c, f) {\n        this.c.p(c);\n        var raw = dopt(c, this.o, this.v && 2, f && 4, !f);\n        if (this.v)\n            zlh(raw, this.o), this.v = 0;\n        if (f)\n            wbytes(raw, raw.length - 4, this.c.d());\n        this.ondata(raw, f);\n    };\n    return Zlib;\n}());\nexport { Zlib };\n/**\n * Asynchronous streaming Zlib compression\n */\nvar AsyncZlib = /*#__PURE__*/ (function () {\n    function AsyncZlib(opts, cb) {\n        astrmify([\n            bDflt,\n            zle,\n            function () { return [astrm, Deflate, Zlib]; }\n        ], this, AsyncCmpStrm.call(this, opts, cb), function (ev) {\n            var strm = new Zlib(ev.data);\n            onmessage = astrm(strm);\n        }, 10);\n    }\n    return AsyncZlib;\n}());\nexport { AsyncZlib };\nexport function zlib(data, opts, cb) {\n    if (!cb)\n        cb = opts, opts = {};\n    if (typeof cb != 'function')\n        err(7);\n    return cbify(data, opts, [\n        bDflt,\n        zle,\n        function () { return [zlibSync]; }\n    ], function (ev) { return pbf(zlibSync(ev.data[0], ev.data[1])); }, 4, cb);\n}\n/**\n * Compress data with Zlib\n * @param data The data to compress\n * @param opts The compression options\n * @returns The zlib-compressed version of the data\n */\nexport function zlibSync(data, opts) {\n    if (!opts)\n        opts = {};\n    var a = adler();\n    a.p(data);\n    var d = dopt(data, opts, 2, 4);\n    return zlh(d, opts), wbytes(d, d.length - 4, a.d()), d;\n}\n/**\n * Streaming Zlib decompression\n */\nvar Unzlib = /*#__PURE__*/ (function () {\n    /**\n     * Creates a Zlib decompression stream\n     * @param cb The callback to call whenever data is inflated\n     */\n    function Unzlib(cb) {\n        this.v = 1;\n        Inflate.call(this, cb);\n    }\n    /**\n     * Pushes a chunk to be unzlibbed\n     * @param chunk The chunk to push\n     * @param final Whether this is the last chunk\n     */\n    Unzlib.prototype.push = function (chunk, final) {\n        Inflate.prototype.e.call(this, chunk);\n        if (this.v) {\n            if (this.p.length < 2 && !final)\n                return;\n            this.p = this.p.subarray(2), this.v = 0;\n        }\n        if (final) {\n            if (this.p.length < 4)\n                err(6, 'invalid zlib data');\n            this.p = this.p.subarray(0, -4);\n        }\n        // necessary to prevent TS from using the closure value\n        // This allows for workerization to function correctly\n        Inflate.prototype.c.call(this, final);\n    };\n    return Unzlib;\n}());\nexport { Unzlib };\n/**\n * Asynchronous streaming Zlib decompression\n */\nvar AsyncUnzlib = /*#__PURE__*/ (function () {\n    /**\n     * Creates an asynchronous Zlib decompression stream\n     * @param cb The callback to call whenever data is deflated\n     */\n    function AsyncUnzlib(cb) {\n        this.ondata = cb;\n        astrmify([\n            bInflt,\n            zule,\n            function () { return [astrm, Inflate, Unzlib]; }\n        ], this, 0, function () {\n            var strm = new Unzlib();\n            onmessage = astrm(strm);\n        }, 11);\n    }\n    return AsyncUnzlib;\n}());\nexport { AsyncUnzlib };\nexport function unzlib(data, opts, cb) {\n    if (!cb)\n        cb = opts, opts = {};\n    if (typeof cb != 'function')\n        err(7);\n    return cbify(data, opts, [\n        bInflt,\n        zule,\n        function () { return [unzlibSync]; }\n    ], function (ev) { return pbf(unzlibSync(ev.data[0], gu8(ev.data[1]))); }, 5, cb);\n}\n/**\n * Expands Zlib data\n * @param data The data to decompress\n * @param out Where to write the data. Saves memory if you know the decompressed size and provide an output buffer of that length.\n * @returns The decompressed version of the data\n */\nexport function unzlibSync(data, out) {\n    return inflt((zlv(data), data.subarray(2, -4)), out);\n}\n// Default algorithm for compression (used because having a known output size allows faster decompression)\nexport { gzip as compress, AsyncGzip as AsyncCompress };\n// Default algorithm for compression (used because having a known output size allows faster decompression)\nexport { gzipSync as compressSync, Gzip as Compress };\n/**\n * Streaming GZIP, Zlib, or raw DEFLATE decompression\n */\nvar Decompress = /*#__PURE__*/ (function () {\n    /**\n     * Creates a decompression stream\n     * @param cb The callback to call whenever data is decompressed\n     */\n    function Decompress(cb) {\n        this.G = Gunzip;\n        this.I = Inflate;\n        this.Z = Unzlib;\n        this.ondata = cb;\n    }\n    /**\n     * Pushes a chunk to be decompressed\n     * @param chunk The chunk to push\n     * @param final Whether this is the last chunk\n     */\n    Decompress.prototype.push = function (chunk, final) {\n        if (!this.ondata)\n            err(5);\n        if (!this.s) {\n            if (this.p && this.p.length) {\n                var n = new u8(this.p.length + chunk.length);\n                n.set(this.p), n.set(chunk, this.p.length);\n            }\n            else\n                this.p = chunk;\n            if (this.p.length > 2) {\n                var _this_1 = this;\n                var cb = function () { _this_1.ondata.apply(_this_1, arguments); };\n                this.s = (this.p[0] == 31 && this.p[1] == 139 && this.p[2] == 8)\n                    ? new this.G(cb)\n                    : ((this.p[0] & 15) != 8 || (this.p[0] >> 4) > 7 || ((this.p[0] << 8 | this.p[1]) % 31))\n                        ? new this.I(cb)\n                        : new this.Z(cb);\n                this.s.push(this.p, final);\n                this.p = null;\n            }\n        }\n        else\n            this.s.push(chunk, final);\n    };\n    return Decompress;\n}());\nexport { Decompress };\n/**\n * Asynchronous streaming GZIP, Zlib, or raw DEFLATE decompression\n */\nvar AsyncDecompress = /*#__PURE__*/ (function () {\n    /**\n   * Creates an asynchronous decompression stream\n   * @param cb The callback to call whenever data is decompressed\n   */\n    function AsyncDecompress(cb) {\n        this.G = AsyncGunzip;\n        this.I = AsyncInflate;\n        this.Z = AsyncUnzlib;\n        this.ondata = cb;\n    }\n    /**\n     * Pushes a chunk to be decompressed\n     * @param chunk The chunk to push\n     * @param final Whether this is the last chunk\n     */\n    AsyncDecompress.prototype.push = function (chunk, final) {\n        Decompress.prototype.push.call(this, chunk, final);\n    };\n    return AsyncDecompress;\n}());\nexport { AsyncDecompress };\nexport function decompress(data, opts, cb) {\n    if (!cb)\n        cb = opts, opts = {};\n    if (typeof cb != 'function')\n        err(7);\n    return (data[0] == 31 && data[1] == 139 && data[2] == 8)\n        ? gunzip(data, opts, cb)\n        : ((data[0] & 15) != 8 || (data[0] >> 4) > 7 || ((data[0] << 8 | data[1]) % 31))\n            ? inflate(data, opts, cb)\n            : unzlib(data, opts, cb);\n}\n/**\n * Expands compressed GZIP, Zlib, or raw DEFLATE data, automatically detecting the format\n * @param data The data to decompress\n * @param out Where to write the data. Saves memory if you know the decompressed size and provide an output buffer of that length.\n * @returns The decompressed version of the data\n */\nexport function decompressSync(data, out) {\n    return (data[0] == 31 && data[1] == 139 && data[2] == 8)\n        ? gunzipSync(data, out)\n        : ((data[0] & 15) != 8 || (data[0] >> 4) > 7 || ((data[0] << 8 | data[1]) % 31))\n            ? inflateSync(data, out)\n            : unzlibSync(data, out);\n}\n// flatten a directory structure\nvar fltn = function (d, p, t, o) {\n    for (var k in d) {\n        var val = d[k], n = p + k, op = o;\n        if (Array.isArray(val))\n            op = mrg(o, val[1]), val = val[0];\n        if (val instanceof u8)\n            t[n] = [val, op];\n        else {\n            t[n += '/'] = [new u8(0), op];\n            fltn(val, n, t, o);\n        }\n    }\n};\n// text encoder\nvar te = typeof TextEncoder != 'undefined' && /*#__PURE__*/ new TextEncoder();\n// text decoder\nvar td = typeof TextDecoder != 'undefined' && /*#__PURE__*/ new TextDecoder();\n// text decoder stream\nvar tds = 0;\ntry {\n    td.decode(et, { stream: true });\n    tds = 1;\n}\ncatch (e) { }\n// decode UTF8\nvar dutf8 = function (d) {\n    for (var r = '', i = 0;;) {\n        var c = d[i++];\n        var eb = (c > 127) + (c > 223) + (c > 239);\n        if (i + eb > d.length)\n            return [r, slc(d, i - 1)];\n        if (!eb)\n            r += String.fromCharCode(c);\n        else if (eb == 3) {\n            c = ((c & 15) << 18 | (d[i++] & 63) << 12 | (d[i++] & 63) << 6 | (d[i++] & 63)) - 65536,\n                r += String.fromCharCode(55296 | (c >> 10), 56320 | (c & 1023));\n        }\n        else if (eb & 1)\n            r += String.fromCharCode((c & 31) << 6 | (d[i++] & 63));\n        else\n            r += String.fromCharCode((c & 15) << 12 | (d[i++] & 63) << 6 | (d[i++] & 63));\n    }\n};\n/**\n * Streaming UTF-8 decoding\n */\nvar DecodeUTF8 = /*#__PURE__*/ (function () {\n    /**\n     * Creates a UTF-8 decoding stream\n     * @param cb The callback to call whenever data is decoded\n     */\n    function DecodeUTF8(cb) {\n        this.ondata = cb;\n        if (tds)\n            this.t = new TextDecoder();\n        else\n            this.p = et;\n    }\n    /**\n     * Pushes a chunk to be decoded from UTF-8 binary\n     * @param chunk The chunk to push\n     * @param final Whether this is the last chunk\n     */\n    DecodeUTF8.prototype.push = function (chunk, final) {\n        if (!this.ondata)\n            err(5);\n        final = !!final;\n        if (this.t) {\n            this.ondata(this.t.decode(chunk, { stream: true }), final);\n            if (final) {\n                if (this.t.decode().length)\n                    err(8);\n                this.t = null;\n            }\n            return;\n        }\n        if (!this.p)\n            err(4);\n        var dat = new u8(this.p.length + chunk.length);\n        dat.set(this.p);\n        dat.set(chunk, this.p.length);\n        var _a = dutf8(dat), ch = _a[0], np = _a[1];\n        if (final) {\n            if (np.length)\n                err(8);\n            this.p = null;\n        }\n        else\n            this.p = np;\n        this.ondata(ch, final);\n    };\n    return DecodeUTF8;\n}());\nexport { DecodeUTF8 };\n/**\n * Streaming UTF-8 encoding\n */\nvar EncodeUTF8 = /*#__PURE__*/ (function () {\n    /**\n     * Creates a UTF-8 decoding stream\n     * @param cb The callback to call whenever data is encoded\n     */\n    function EncodeUTF8(cb) {\n        this.ondata = cb;\n    }\n    /**\n     * Pushes a chunk to be encoded to UTF-8\n     * @param chunk The string data to push\n     * @param final Whether this is the last chunk\n     */\n    EncodeUTF8.prototype.push = function (chunk, final) {\n        if (!this.ondata)\n            err(5);\n        if (this.d)\n            err(4);\n        this.ondata(strToU8(chunk), this.d = final || false);\n    };\n    return EncodeUTF8;\n}());\nexport { EncodeUTF8 };\n/**\n * Converts a string into a Uint8Array for use with compression/decompression methods\n * @param str The string to encode\n * @param latin1 Whether or not to interpret the data as Latin-1. This should\n *               not need to be true unless decoding a binary string.\n * @returns The string encoded in UTF-8/Latin-1 binary\n */\nexport function strToU8(str, latin1) {\n    if (latin1) {\n        var ar_1 = new u8(str.length);\n        for (var i = 0; i < str.length; ++i)\n            ar_1[i] = str.charCodeAt(i);\n        return ar_1;\n    }\n    if (te)\n        return te.encode(str);\n    var l = str.length;\n    var ar = new u8(str.length + (str.length >> 1));\n    var ai = 0;\n    var w = function (v) { ar[ai++] = v; };\n    for (var i = 0; i < l; ++i) {\n        if (ai + 5 > ar.length) {\n            var n = new u8(ai + 8 + ((l - i) << 1));\n            n.set(ar);\n            ar = n;\n        }\n        var c = str.charCodeAt(i);\n        if (c < 128 || latin1)\n            w(c);\n        else if (c < 2048)\n            w(192 | (c >> 6)), w(128 | (c & 63));\n        else if (c > 55295 && c < 57344)\n            c = 65536 + (c & 1023 << 10) | (str.charCodeAt(++i) & 1023),\n                w(240 | (c >> 18)), w(128 | ((c >> 12) & 63)), w(128 | ((c >> 6) & 63)), w(128 | (c & 63));\n        else\n            w(224 | (c >> 12)), w(128 | ((c >> 6) & 63)), w(128 | (c & 63));\n    }\n    return slc(ar, 0, ai);\n}\n/**\n * Converts a Uint8Array to a string\n * @param dat The data to decode to string\n * @param latin1 Whether or not to interpret the data as Latin-1. This should\n *               not need to be true unless encoding to binary string.\n * @returns The original UTF-8/Latin-1 string\n */\nexport function strFromU8(dat, latin1) {\n    if (latin1) {\n        var r = '';\n        for (var i = 0; i < dat.length; i += 16384)\n            r += String.fromCharCode.apply(null, dat.subarray(i, i + 16384));\n        return r;\n    }\n    else if (td)\n        return td.decode(dat);\n    else {\n        var _a = dutf8(dat), out = _a[0], ext = _a[1];\n        if (ext.length)\n            err(8);\n        return out;\n    }\n}\n;\n// deflate bit flag\nvar dbf = function (l) { return l == 1 ? 3 : l < 6 ? 2 : l == 9 ? 1 : 0; };\n// skip local zip header\nvar slzh = function (d, b) { return b + 30 + b2(d, b + 26) + b2(d, b + 28); };\n// read zip header\nvar zh = function (d, b, z) {\n    var fnl = b2(d, b + 28), fn = strFromU8(d.subarray(b + 46, b + 46 + fnl), !(b2(d, b + 8) & 2048)), es = b + 46 + fnl, bs = b4(d, b + 20);\n    var _a = z && bs == 4294967295 ? z64e(d, es) : [bs, b4(d, b + 24), b4(d, b + 42)], sc = _a[0], su = _a[1], off = _a[2];\n    return [b2(d, b + 10), sc, su, fn, es + b2(d, b + 30) + b2(d, b + 32), off];\n};\n// read zip64 extra field\nvar z64e = function (d, b) {\n    for (; b2(d, b) != 1; b += 4 + b2(d, b + 2))\n        ;\n    return [b8(d, b + 12), b8(d, b + 4), b8(d, b + 20)];\n};\n// extra field length\nvar exfl = function (ex) {\n    var le = 0;\n    if (ex) {\n        for (var k in ex) {\n            var l = ex[k].length;\n            if (l > 65535)\n                err(9);\n            le += l + 4;\n        }\n    }\n    return le;\n};\n// write zip header\nvar wzh = function (d, b, f, fn, u, c, ce, co) {\n    var fl = fn.length, ex = f.extra, col = co && co.length;\n    var exl = exfl(ex);\n    wbytes(d, b, ce != null ? 0x2014B50 : 0x4034B50), b += 4;\n    if (ce != null)\n        d[b++] = 20, d[b++] = f.os;\n    d[b] = 20, b += 2; // spec compliance? what's that?\n    d[b++] = (f.flag << 1) | (c == null && 8), d[b++] = u && 8;\n    d[b++] = f.compression & 255, d[b++] = f.compression >> 8;\n    var dt = new Date(f.mtime == null ? Date.now() : f.mtime), y = dt.getFullYear() - 1980;\n    if (y < 0 || y > 119)\n        err(10);\n    wbytes(d, b, (y << 25) | ((dt.getMonth() + 1) << 21) | (dt.getDate() << 16) | (dt.getHours() << 11) | (dt.getMinutes() << 5) | (dt.getSeconds() >>> 1)), b += 4;\n    if (c != null) {\n        wbytes(d, b, f.crc);\n        wbytes(d, b + 4, c);\n        wbytes(d, b + 8, f.size);\n    }\n    wbytes(d, b + 12, fl);\n    wbytes(d, b + 14, exl), b += 16;\n    if (ce != null) {\n        wbytes(d, b, col);\n        wbytes(d, b + 6, f.attrs);\n        wbytes(d, b + 10, ce), b += 14;\n    }\n    d.set(fn, b);\n    b += fl;\n    if (exl) {\n        for (var k in ex) {\n            var exf = ex[k], l = exf.length;\n            wbytes(d, b, +k);\n            wbytes(d, b + 2, l);\n            d.set(exf, b + 4), b += 4 + l;\n        }\n    }\n    if (col)\n        d.set(co, b), b += col;\n    return b;\n};\n// write zip footer (end of central directory)\nvar wzf = function (o, b, c, d, e) {\n    wbytes(o, b, 0x6054B50); // skip disk\n    wbytes(o, b + 8, c);\n    wbytes(o, b + 10, c);\n    wbytes(o, b + 12, d);\n    wbytes(o, b + 16, e);\n};\n/**\n * A pass-through stream to keep data uncompressed in a ZIP archive.\n */\nvar ZipPassThrough = /*#__PURE__*/ (function () {\n    /**\n     * Creates a pass-through stream that can be added to ZIP archives\n     * @param filename The filename to associate with this data stream\n     */\n    function ZipPassThrough(filename) {\n        this.filename = filename;\n        this.c = crc();\n        this.size = 0;\n        this.compression = 0;\n    }\n    /**\n     * Processes a chunk and pushes to the output stream. You can override this\n     * method in a subclass for custom behavior, but by default this passes\n     * the data through. You must call this.ondata(err, chunk, final) at some\n     * point in this method.\n     * @param chunk The chunk to process\n     * @param final Whether this is the last chunk\n     */\n    ZipPassThrough.prototype.process = function (chunk, final) {\n        this.ondata(null, chunk, final);\n    };\n    /**\n     * Pushes a chunk to be added. If you are subclassing this with a custom\n     * compression algorithm, note that you must push data from the source\n     * file only, pre-compression.\n     * @param chunk The chunk to push\n     * @param final Whether this is the last chunk\n     */\n    ZipPassThrough.prototype.push = function (chunk, final) {\n        if (!this.ondata)\n            err(5);\n        this.c.p(chunk);\n        this.size += chunk.length;\n        if (final)\n            this.crc = this.c.d();\n        this.process(chunk, final || false);\n    };\n    return ZipPassThrough;\n}());\nexport { ZipPassThrough };\n// I don't extend because TypeScript extension adds 1kB of runtime bloat\n/**\n * Streaming DEFLATE compression for ZIP archives. Prefer using AsyncZipDeflate\n * for better performance\n */\nvar ZipDeflate = /*#__PURE__*/ (function () {\n    /**\n     * Creates a DEFLATE stream that can be added to ZIP archives\n     * @param filename The filename to associate with this data stream\n     * @param opts The compression options\n     */\n    function ZipDeflate(filename, opts) {\n        var _this_1 = this;\n        if (!opts)\n            opts = {};\n        ZipPassThrough.call(this, filename);\n        this.d = new Deflate(opts, function (dat, final) {\n            _this_1.ondata(null, dat, final);\n        });\n        this.compression = 8;\n        this.flag = dbf(opts.level);\n    }\n    ZipDeflate.prototype.process = function (chunk, final) {\n        try {\n            this.d.push(chunk, final);\n        }\n        catch (e) {\n            this.ondata(e, null, final);\n        }\n    };\n    /**\n     * Pushes a chunk to be deflated\n     * @param chunk The chunk to push\n     * @param final Whether this is the last chunk\n     */\n    ZipDeflate.prototype.push = function (chunk, final) {\n        ZipPassThrough.prototype.push.call(this, chunk, final);\n    };\n    return ZipDeflate;\n}());\nexport { ZipDeflate };\n/**\n * Asynchronous streaming DEFLATE compression for ZIP archives\n */\nvar AsyncZipDeflate = /*#__PURE__*/ (function () {\n    /**\n     * Creates a DEFLATE stream that can be added to ZIP archives\n     * @param filename The filename to associate with this data stream\n     * @param opts The compression options\n     */\n    function AsyncZipDeflate(filename, opts) {\n        var _this_1 = this;\n        if (!opts)\n            opts = {};\n        ZipPassThrough.call(this, filename);\n        this.d = new AsyncDeflate(opts, function (err, dat, final) {\n            _this_1.ondata(err, dat, final);\n        });\n        this.compression = 8;\n        this.flag = dbf(opts.level);\n        this.terminate = this.d.terminate;\n    }\n    AsyncZipDeflate.prototype.process = function (chunk, final) {\n        this.d.push(chunk, final);\n    };\n    /**\n     * Pushes a chunk to be deflated\n     * @param chunk The chunk to push\n     * @param final Whether this is the last chunk\n     */\n    AsyncZipDeflate.prototype.push = function (chunk, final) {\n        ZipPassThrough.prototype.push.call(this, chunk, final);\n    };\n    return AsyncZipDeflate;\n}());\nexport { AsyncZipDeflate };\n// TODO: Better tree shaking\n/**\n * A zippable archive to which files can incrementally be added\n */\nvar Zip = /*#__PURE__*/ (function () {\n    /**\n     * Creates an empty ZIP archive to which files can be added\n     * @param cb The callback to call whenever data for the generated ZIP archive\n     *           is available\n     */\n    function Zip(cb) {\n        this.ondata = cb;\n        this.u = [];\n        this.d = 1;\n    }\n    /**\n     * Adds a file to the ZIP archive\n     * @param file The file stream to add\n     */\n    Zip.prototype.add = function (file) {\n        var _this_1 = this;\n        if (!this.ondata)\n            err(5);\n        // finishing or finished\n        if (this.d & 2)\n            this.ondata(err(4 + (this.d & 1) * 8, 0, 1), null, false);\n        else {\n            var f = strToU8(file.filename), fl_1 = f.length;\n            var com = file.comment, o = com && strToU8(com);\n            var u = fl_1 != file.filename.length || (o && (com.length != o.length));\n            var hl_1 = fl_1 + exfl(file.extra) + 30;\n            if (fl_1 > 65535)\n                this.ondata(err(11, 0, 1), null, false);\n            var header = new u8(hl_1);\n            wzh(header, 0, file, f, u);\n            var chks_1 = [header];\n            var pAll_1 = function () {\n                for (var _i = 0, chks_2 = chks_1; _i < chks_2.length; _i++) {\n                    var chk = chks_2[_i];\n                    _this_1.ondata(null, chk, false);\n                }\n                chks_1 = [];\n            };\n            var tr_1 = this.d;\n            this.d = 0;\n            var ind_1 = this.u.length;\n            var uf_1 = mrg(file, {\n                f: f,\n                u: u,\n                o: o,\n                t: function () {\n                    if (file.terminate)\n                        file.terminate();\n                },\n                r: function () {\n                    pAll_1();\n                    if (tr_1) {\n                        var nxt = _this_1.u[ind_1 + 1];\n                        if (nxt)\n                            nxt.r();\n                        else\n                            _this_1.d = 1;\n                    }\n                    tr_1 = 1;\n                }\n            });\n            var cl_1 = 0;\n            file.ondata = function (err, dat, final) {\n                if (err) {\n                    _this_1.ondata(err, dat, final);\n                    _this_1.terminate();\n                }\n                else {\n                    cl_1 += dat.length;\n                    chks_1.push(dat);\n                    if (final) {\n                        var dd = new u8(16);\n                        wbytes(dd, 0, 0x8074B50);\n                        wbytes(dd, 4, file.crc);\n                        wbytes(dd, 8, cl_1);\n                        wbytes(dd, 12, file.size);\n                        chks_1.push(dd);\n                        uf_1.c = cl_1, uf_1.b = hl_1 + cl_1 + 16, uf_1.crc = file.crc, uf_1.size = file.size;\n                        if (tr_1)\n                            uf_1.r();\n                        tr_1 = 1;\n                    }\n                    else if (tr_1)\n                        pAll_1();\n                }\n            };\n            this.u.push(uf_1);\n        }\n    };\n    /**\n     * Ends the process of adding files and prepares to emit the final chunks.\n     * This *must* be called after adding all desired files for the resulting\n     * ZIP file to work properly.\n     */\n    Zip.prototype.end = function () {\n        var _this_1 = this;\n        if (this.d & 2) {\n            this.ondata(err(4 + (this.d & 1) * 8, 0, 1), null, true);\n            return;\n        }\n        if (this.d)\n            this.e();\n        else\n            this.u.push({\n                r: function () {\n                    if (!(_this_1.d & 1))\n                        return;\n                    _this_1.u.splice(-1, 1);\n                    _this_1.e();\n                },\n                t: function () { }\n            });\n        this.d = 3;\n    };\n    Zip.prototype.e = function () {\n        var bt = 0, l = 0, tl = 0;\n        for (var _i = 0, _a = this.u; _i < _a.length; _i++) {\n            var f = _a[_i];\n            tl += 46 + f.f.length + exfl(f.extra) + (f.o ? f.o.length : 0);\n        }\n        var out = new u8(tl + 22);\n        for (var _b = 0, _c = this.u; _b < _c.length; _b++) {\n            var f = _c[_b];\n            wzh(out, bt, f, f.f, f.u, f.c, l, f.o);\n            bt += 46 + f.f.length + exfl(f.extra) + (f.o ? f.o.length : 0), l += f.b;\n        }\n        wzf(out, bt, this.u.length, tl, l);\n        this.ondata(null, out, true);\n        this.d = 2;\n    };\n    /**\n     * A method to terminate any internal workers used by the stream. Subsequent\n     * calls to add() will fail.\n     */\n    Zip.prototype.terminate = function () {\n        for (var _i = 0, _a = this.u; _i < _a.length; _i++) {\n            var f = _a[_i];\n            f.t();\n        }\n        this.d = 2;\n    };\n    return Zip;\n}());\nexport { Zip };\nexport function zip(data, opts, cb) {\n    if (!cb)\n        cb = opts, opts = {};\n    if (typeof cb != 'function')\n        err(7);\n    var r = {};\n    fltn(data, '', r, opts);\n    var k = Object.keys(r);\n    var lft = k.length, o = 0, tot = 0;\n    var slft = lft, files = new Array(lft);\n    var term = [];\n    var tAll = function () {\n        for (var i = 0; i < term.length; ++i)\n            term[i]();\n    };\n    var cbd = function (a, b) {\n        mt(function () { cb(a, b); });\n    };\n    mt(function () { cbd = cb; });\n    var cbf = function () {\n        var out = new u8(tot + 22), oe = o, cdl = tot - o;\n        tot = 0;\n        for (var i = 0; i < slft; ++i) {\n            var f = files[i];\n            try {\n                var l = f.c.length;\n                wzh(out, tot, f, f.f, f.u, l);\n                var badd = 30 + f.f.length + exfl(f.extra);\n                var loc = tot + badd;\n                out.set(f.c, loc);\n                wzh(out, o, f, f.f, f.u, l, tot, f.m), o += 16 + badd + (f.m ? f.m.length : 0), tot = loc + l;\n            }\n            catch (e) {\n                return cbd(e, null);\n            }\n        }\n        wzf(out, o, files.length, cdl, oe);\n        cbd(null, out);\n    };\n    if (!lft)\n        cbf();\n    var _loop_1 = function (i) {\n        var fn = k[i];\n        var _a = r[fn], file = _a[0], p = _a[1];\n        var c = crc(), size = file.length;\n        c.p(file);\n        var f = strToU8(fn), s = f.length;\n        var com = p.comment, m = com && strToU8(com), ms = m && m.length;\n        var exl = exfl(p.extra);\n        var compression = p.level == 0 ? 0 : 8;\n        var cbl = function (e, d) {\n            if (e) {\n                tAll();\n                cbd(e, null);\n            }\n            else {\n                var l = d.length;\n                files[i] = mrg(p, {\n                    size: size,\n                    crc: c.d(),\n                    c: d,\n                    f: f,\n                    m: m,\n                    u: s != fn.length || (m && (com.length != ms)),\n                    compression: compression\n                });\n                o += 30 + s + exl + l;\n                tot += 76 + 2 * (s + exl) + (ms || 0) + l;\n                if (!--lft)\n                    cbf();\n            }\n        };\n        if (s > 65535)\n            cbl(err(11, 0, 1), null);\n        if (!compression)\n            cbl(null, file);\n        else if (size < 160000) {\n            try {\n                cbl(null, deflateSync(file, p));\n            }\n            catch (e) {\n                cbl(e, null);\n            }\n        }\n        else\n            term.push(deflate(file, p, cbl));\n    };\n    // Cannot use lft because it can decrease\n    for (var i = 0; i < slft; ++i) {\n        _loop_1(i);\n    }\n    return tAll;\n}\n/**\n * Synchronously creates a ZIP file. Prefer using `zip` for better performance\n * with more than one file.\n * @param data The directory structure for the ZIP archive\n * @param opts The main options, merged with per-file options\n * @returns The generated ZIP archive\n */\nexport function zipSync(data, opts) {\n    if (!opts)\n        opts = {};\n    var r = {};\n    var files = [];\n    fltn(data, '', r, opts);\n    var o = 0;\n    var tot = 0;\n    for (var fn in r) {\n        var _a = r[fn], file = _a[0], p = _a[1];\n        var compression = p.level == 0 ? 0 : 8;\n        var f = strToU8(fn), s = f.length;\n        var com = p.comment, m = com && strToU8(com), ms = m && m.length;\n        var exl = exfl(p.extra);\n        if (s > 65535)\n            err(11);\n        var d = compression ? deflateSync(file, p) : file, l = d.length;\n        var c = crc();\n        c.p(file);\n        files.push(mrg(p, {\n            size: file.length,\n            crc: c.d(),\n            c: d,\n            f: f,\n            m: m,\n            u: s != fn.length || (m && (com.length != ms)),\n            o: o,\n            compression: compression\n        }));\n        o += 30 + s + exl + l;\n        tot += 76 + 2 * (s + exl) + (ms || 0) + l;\n    }\n    var out = new u8(tot + 22), oe = o, cdl = tot - o;\n    for (var i = 0; i < files.length; ++i) {\n        var f = files[i];\n        wzh(out, f.o, f, f.f, f.u, f.c.length);\n        var badd = 30 + f.f.length + exfl(f.extra);\n        out.set(f.c, f.o + badd);\n        wzh(out, o, f, f.f, f.u, f.c.length, f.o, f.m), o += 16 + badd + (f.m ? f.m.length : 0);\n    }\n    wzf(out, o, files.length, cdl, oe);\n    return out;\n}\n/**\n * Streaming pass-through decompression for ZIP archives\n */\nvar UnzipPassThrough = /*#__PURE__*/ (function () {\n    function UnzipPassThrough() {\n    }\n    UnzipPassThrough.prototype.push = function (data, final) {\n        this.ondata(null, data, final);\n    };\n    UnzipPassThrough.compression = 0;\n    return UnzipPassThrough;\n}());\nexport { UnzipPassThrough };\n/**\n * Streaming DEFLATE decompression for ZIP archives. Prefer AsyncZipInflate for\n * better performance.\n */\nvar UnzipInflate = /*#__PURE__*/ (function () {\n    /**\n     * Creates a DEFLATE decompression that can be used in ZIP archives\n     */\n    function UnzipInflate() {\n        var _this_1 = this;\n        this.i = new Inflate(function (dat, final) {\n            _this_1.ondata(null, dat, final);\n        });\n    }\n    UnzipInflate.prototype.push = function (data, final) {\n        try {\n            this.i.push(data, final);\n        }\n        catch (e) {\n            this.ondata(e, null, final);\n        }\n    };\n    UnzipInflate.compression = 8;\n    return UnzipInflate;\n}());\nexport { UnzipInflate };\n/**\n * Asynchronous streaming DEFLATE decompression for ZIP archives\n */\nvar AsyncUnzipInflate = /*#__PURE__*/ (function () {\n    /**\n     * Creates a DEFLATE decompression that can be used in ZIP archives\n     */\n    function AsyncUnzipInflate(_, sz) {\n        var _this_1 = this;\n        if (sz < 320000) {\n            this.i = new Inflate(function (dat, final) {\n                _this_1.ondata(null, dat, final);\n            });\n        }\n        else {\n            this.i = new AsyncInflate(function (err, dat, final) {\n                _this_1.ondata(err, dat, final);\n            });\n            this.terminate = this.i.terminate;\n        }\n    }\n    AsyncUnzipInflate.prototype.push = function (data, final) {\n        if (this.i.terminate)\n            data = slc(data, 0);\n        this.i.push(data, final);\n    };\n    AsyncUnzipInflate.compression = 8;\n    return AsyncUnzipInflate;\n}());\nexport { AsyncUnzipInflate };\n/**\n * A ZIP archive decompression stream that emits files as they are discovered\n */\nvar Unzip = /*#__PURE__*/ (function () {\n    /**\n     * Creates a ZIP decompression stream\n     * @param cb The callback to call whenever a file in the ZIP archive is found\n     */\n    function Unzip(cb) {\n        this.onfile = cb;\n        this.k = [];\n        this.o = {\n            0: UnzipPassThrough\n        };\n        this.p = et;\n    }\n    /**\n     * Pushes a chunk to be unzipped\n     * @param chunk The chunk to push\n     * @param final Whether this is the last chunk\n     */\n    Unzip.prototype.push = function (chunk, final) {\n        var _this_1 = this;\n        if (!this.onfile)\n            err(5);\n        if (!this.p)\n            err(4);\n        if (this.c > 0) {\n            var len = Math.min(this.c, chunk.length);\n            var toAdd = chunk.subarray(0, len);\n            this.c -= len;\n            if (this.d)\n                this.d.push(toAdd, !this.c);\n            else\n                this.k[0].push(toAdd);\n            chunk = chunk.subarray(len);\n            if (chunk.length)\n                return this.push(chunk, final);\n        }\n        else {\n            var f = 0, i = 0, is = void 0, buf = void 0;\n            if (!this.p.length)\n                buf = chunk;\n            else if (!chunk.length)\n                buf = this.p;\n            else {\n                buf = new u8(this.p.length + chunk.length);\n                buf.set(this.p), buf.set(chunk, this.p.length);\n            }\n            var l = buf.length, oc = this.c, add = oc && this.d;\n            var _loop_2 = function () {\n                var _a;\n                var sig = b4(buf, i);\n                if (sig == 0x4034B50) {\n                    f = 1, is = i;\n                    this_1.d = null;\n                    this_1.c = 0;\n                    var bf = b2(buf, i + 6), cmp_1 = b2(buf, i + 8), u = bf & 2048, dd = bf & 8, fnl = b2(buf, i + 26), es = b2(buf, i + 28);\n                    if (l > i + 30 + fnl + es) {\n                        var chks_3 = [];\n                        this_1.k.unshift(chks_3);\n                        f = 2;\n                        var sc_1 = b4(buf, i + 18), su_1 = b4(buf, i + 22);\n                        var fn_1 = strFromU8(buf.subarray(i + 30, i += 30 + fnl), !u);\n                        if (sc_1 == 4294967295) {\n                            _a = dd ? [-2] : z64e(buf, i), sc_1 = _a[0], su_1 = _a[1];\n                        }\n                        else if (dd)\n                            sc_1 = -1;\n                        i += es;\n                        this_1.c = sc_1;\n                        var d_1;\n                        var file_1 = {\n                            name: fn_1,\n                            compression: cmp_1,\n                            start: function () {\n                                if (!file_1.ondata)\n                                    err(5);\n                                if (!sc_1)\n                                    file_1.ondata(null, et, true);\n                                else {\n                                    var ctr = _this_1.o[cmp_1];\n                                    if (!ctr)\n                                        file_1.ondata(err(14, 'unknown compression type ' + cmp_1, 1), null, false);\n                                    d_1 = sc_1 < 0 ? new ctr(fn_1) : new ctr(fn_1, sc_1, su_1);\n                                    d_1.ondata = function (err, dat, final) { file_1.ondata(err, dat, final); };\n                                    for (var _i = 0, chks_4 = chks_3; _i < chks_4.length; _i++) {\n                                        var dat = chks_4[_i];\n                                        d_1.push(dat, false);\n                                    }\n                                    if (_this_1.k[0] == chks_3 && _this_1.c)\n                                        _this_1.d = d_1;\n                                    else\n                                        d_1.push(et, true);\n                                }\n                            },\n                            terminate: function () {\n                                if (d_1 && d_1.terminate)\n                                    d_1.terminate();\n                            }\n                        };\n                        if (sc_1 >= 0)\n                            file_1.size = sc_1, file_1.originalSize = su_1;\n                        this_1.onfile(file_1);\n                    }\n                    return \"break\";\n                }\n                else if (oc) {\n                    if (sig == 0x8074B50) {\n                        is = i += 12 + (oc == -2 && 8), f = 3, this_1.c = 0;\n                        return \"break\";\n                    }\n                    else if (sig == 0x2014B50) {\n                        is = i -= 4, f = 3, this_1.c = 0;\n                        return \"break\";\n                    }\n                }\n            };\n            var this_1 = this;\n            for (; i < l - 4; ++i) {\n                var state_1 = _loop_2();\n                if (state_1 === \"break\")\n                    break;\n            }\n            this.p = et;\n            if (oc < 0) {\n                var dat = f ? buf.subarray(0, is - 12 - (oc == -2 && 8) - (b4(buf, is - 16) == 0x8074B50 && 4)) : buf.subarray(0, i);\n                if (add)\n                    add.push(dat, !!f);\n                else\n                    this.k[+(f == 2)].push(dat);\n            }\n            if (f & 2)\n                return this.push(buf.subarray(i), final);\n            this.p = buf.subarray(i);\n        }\n        if (final) {\n            if (this.c)\n                err(13);\n            this.p = null;\n        }\n    };\n    /**\n     * Registers a decoder with the stream, allowing for files compressed with\n     * the compression type provided to be expanded correctly\n     * @param decoder The decoder constructor\n     */\n    Unzip.prototype.register = function (decoder) {\n        this.o[decoder.compression] = decoder;\n    };\n    return Unzip;\n}());\nexport { Unzip };\nvar mt = typeof queueMicrotask == 'function' ? queueMicrotask : typeof setTimeout == 'function' ? setTimeout : function (fn) { fn(); };\nexport function unzip(data, opts, cb) {\n    if (!cb)\n        cb = opts, opts = {};\n    if (typeof cb != 'function')\n        err(7);\n    var term = [];\n    var tAll = function () {\n        for (var i = 0; i < term.length; ++i)\n            term[i]();\n    };\n    var files = {};\n    var cbd = function (a, b) {\n        mt(function () { cb(a, b); });\n    };\n    mt(function () { cbd = cb; });\n    var e = data.length - 22;\n    for (; b4(data, e) != 0x6054B50; --e) {\n        if (!e || data.length - e > 65558) {\n            cbd(err(13, 0, 1), null);\n            return tAll;\n        }\n    }\n    ;\n    var lft = b2(data, e + 8);\n    if (lft) {\n        var c = lft;\n        var o = b4(data, e + 16);\n        var z = o == 4294967295;\n        if (z) {\n            e = b4(data, e - 12);\n            if (b4(data, e) != 0x6064B50) {\n                cbd(err(13, 0, 1), null);\n                return tAll;\n            }\n            c = lft = b4(data, e + 32);\n            o = b4(data, e + 48);\n        }\n        var fltr = opts && opts.filter;\n        var _loop_3 = function (i) {\n            var _a = zh(data, o, z), c_1 = _a[0], sc = _a[1], su = _a[2], fn = _a[3], no = _a[4], off = _a[5], b = slzh(data, off);\n            o = no;\n            var cbl = function (e, d) {\n                if (e) {\n                    tAll();\n                    cbd(e, null);\n                }\n                else {\n                    if (d)\n                        files[fn] = d;\n                    if (!--lft)\n                        cbd(null, files);\n                }\n            };\n            if (!fltr || fltr({\n                name: fn,\n                size: sc,\n                originalSize: su,\n                compression: c_1\n            })) {\n                if (!c_1)\n                    cbl(null, slc(data, b, b + sc));\n                else if (c_1 == 8) {\n                    var infl = data.subarray(b, b + sc);\n                    if (sc < 320000) {\n                        try {\n                            cbl(null, inflateSync(infl, new u8(su)));\n                        }\n                        catch (e) {\n                            cbl(e, null);\n                        }\n                    }\n                    else\n                        term.push(inflate(infl, { size: su }, cbl));\n                }\n                else\n                    cbl(err(14, 'unknown compression type ' + c_1, 1), null);\n            }\n            else\n                cbl(null, null);\n        };\n        for (var i = 0; i < c; ++i) {\n            _loop_3(i);\n        }\n    }\n    else\n        cbd(null, {});\n    return tAll;\n}\n/**\n * Synchronously decompresses a ZIP archive. Prefer using `unzip` for better\n * performance with more than one file.\n * @param data The raw compressed ZIP file\n * @param opts The ZIP extraction options\n * @returns The decompressed files\n */\nexport function unzipSync(data, opts) {\n    var files = {};\n    var e = data.length - 22;\n    for (; b4(data, e) != 0x6054B50; --e) {\n        if (!e || data.length - e > 65558)\n            err(13);\n    }\n    ;\n    var c = b2(data, e + 8);\n    if (!c)\n        return {};\n    var o = b4(data, e + 16);\n    var z = o == 4294967295;\n    if (z) {\n        e = b4(data, e - 12);\n        if (b4(data, e) != 0x6064B50)\n            err(13);\n        c = b4(data, e + 32);\n        o = b4(data, e + 48);\n    }\n    var fltr = opts && opts.filter;\n    for (var i = 0; i < c; ++i) {\n        var _a = zh(data, o, z), c_2 = _a[0], sc = _a[1], su = _a[2], fn = _a[3], no = _a[4], off = _a[5], b = slzh(data, off);\n        o = no;\n        if (!fltr || fltr({\n            name: fn,\n            size: sc,\n            originalSize: su,\n            compression: c_2\n        })) {\n            if (!c_2)\n                files[fn] = slc(data, b, b + sc);\n            else if (c_2 == 8)\n                files[fn] = inflateSync(data.subarray(b, b + sc), new u8(su));\n            else\n                err(14, 'unknown compression type ' + c_2);\n        }\n    }\n    return files;\n}\n","/** @fileoverview Functions used by multiple content-specific cache modules */\n\nimport {decompressSync, strFromU8} from 'fflate';\n\nimport version from '../../version';\nimport {getEarlyTaxid, slug, getDir} from '../../lib';\nimport {organismMetadata} from '../organism-metadata';\n\n/** Reports if current organism has a gene structure cache */\nexport function supportsCache(orgName, cacheName) {\n  const metadata = parseOrgMetadata(orgName);\n  const cacheProp = 'has' + cacheName + 'Cache';\n  return metadata[cacheProp] && metadata[cacheProp] === true;\n}\n\n/** Get URL for gene structure cache file */\nexport function getCacheUrl(orgName, cacheDir, cacheType, fileType='tsv') {\n  const organism = slug(orgName);\n  if (!cacheDir) {\n    cacheDir = getDir('cache/' + cacheType + '/');\n  } else {\n    cacheDir += cacheType + '/';\n  }\n\n  const cacheUrl =\n    cacheDir + organism + '-' + cacheType + '.' + fileType + '.gz';\n\n  return cacheUrl;\n}\n\n/**\n * Build full ID from prefix (e.g. ENSG or IPR) and slim ID (e.g. 223972)\n *\n * Example output ID: ENSG00000223972\n * */\nexport function getFullId(prefix, slimId, fullNumLength=11) {\n\n  // C. elegans (prefix: WBGene) has special IDs, e.g. WBGene00197333\n  if (prefix === 'WBGene') fullNumLength = 8;\n\n  // Zero-pad the slim ID, e.g. 223972 -> 00000223972\n  const zeroPaddedId = slimId.padStart(fullNumLength, '0');\n\n  return prefix + zeroPaddedId;\n}\n\nexport async function cacheFetch(url) {\n\n  const cache = await caches.open(`ideogram-${version}`);\n\n  const decompressedUrl = url.replace('.gz', '');\n  const response = await cache.match(decompressedUrl);\n  if (typeof response === 'undefined') {\n    // If cache miss, then fetch and add response to cache\n    const rawResponse = await fetch(url);\n    const blob = await rawResponse.blob();\n    const uint8Array = new Uint8Array(await blob.arrayBuffer());\n    const data = strFromU8(decompressSync(uint8Array));\n    const decompressedResponse = new Response(\n      new Blob([data], {type: 'text/tab-separated-values'}),\n      rawResponse.init\n    );\n    await cache.put(decompressedUrl, decompressedResponse);\n    return await cache.match(decompressedUrl);\n  }\n  return await cache.match(decompressedUrl);\n}\n\n/** Get organism's metadata fields */\nexport function parseOrgMetadata(orgName) {\n  const taxid = getEarlyTaxid(orgName);\n  return organismMetadata[taxid] || {};\n}\n\n/** Fetch URL from service worker cache, call given parsing function */\nexport async function fetchAndParse(\n  cacheUrl, perfTimes, parseFn, orgName=null\n) {\n  const fetchStartTime = performance.now();\n  const response = await cacheFetch(cacheUrl);\n  let data;\n  if (cacheUrl.includes('.json')) {\n    data = await response.json();\n  } else {\n    data = await response.text();\n  }\n  const fetchEndTime = performance.now();\n  perfTimes.fetch = Math.round(fetchEndTime - fetchStartTime);\n\n  const parsedCache = parseFn(data, perfTimes, orgName);\n  perfTimes.parseCache = Math.round(performance.now() - fetchEndTime);\n\n  return [parsedCache, perfTimes];\n}\n\n/** Print size and time of given parsed cache */\nexport function inspectWorker(cacheName, json) {\n  const size = new TextEncoder().encode(JSON.stringify(json)).length;\n  const kiloBytes = size / 1024;\n  const megaBytes = kiloBytes / 1024;\n  console.log(`Parsed ${cacheName}Cache size: ${megaBytes} MiB`);\n  console.timeEnd(`${cacheName}CacheWorker`);\n}\n","import {fetchAndParse, inspectWorker} from './cache-lib';\n\n/** Parse compressed feature subparts to more easily computable format */\nfunction deserializeSubparts(rawSubparts, subpartKeys) {\n  const subparts = [];\n  for (let i = 0; i < rawSubparts.length; i++) {\n    const rawSubpart = rawSubparts[i].split(';');\n    const subpartType = subpartKeys[parseInt(rawSubpart[0])];\n    const start = parseInt(rawSubpart[1]);\n    const length = parseInt(rawSubpart[2]);\n    const subpart = [subpartType, start, length];\n    subparts.push(subpart);\n  }\n  return subparts;\n}\n\n/** Parse metainformation header lines, i.e. those beginning  \"## \"\" */\nfunction parseMetainformationHeader(line) {\n  const splitHead = line.split(' keys: ');\n  if (splitHead.length < 2) return [null];\n  const metaHeader = splitHead[0].split('## ')[1];\n  const keys = {};\n  splitHead[1].split(', ').forEach(entry => {\n    const splitEntry = entry.split(' = ');\n    keys[splitEntry[0]] = splitEntry[1];\n  });\n  return [metaHeader, keys];\n}\n\n/** Parse a gene structure cache TSV file, return array of useful transforms */\nexport function parseCache(rawTsv, perfTimes) {\n  const featuresByGene = {};\n\n  let t0 = performance.now();\n  const lines = rawTsv.split(/\\r\\n|\\n/);\n  perfTimes.rawTsvSplit = Math.round(performance.now() - t0);\n\n  let biotypeKeys, subpartKeys;\n\n  t0 = performance.now();\n  for (let i = 0; i < lines.length; i++) {\n    const line = lines[i];\n    if (line === '') continue; // Skip empty lines\n\n    // Parse header\n    if (line[0] === '#') {\n\n      // Parse metainformation headers\n      if (line[1] === '#') {\n        const [metaHeader, keys] = parseMetainformationHeader(line);\n        if (metaHeader === 'biotype') {\n          biotypeKeys = keys;\n        } else if (metaHeader === 'subpart') {\n          subpartKeys = keys;\n        }\n      }\n      continue;\n    }\n    const splitLine = line.trim().split(/\\t/);\n\n    const [\n      name, biotypeCompressed, strand\n    ] = splitLine.slice(0, 3);\n\n    const gene = name.split('-').slice(0, -1).join('-');\n\n    const rawSubparts = splitLine.slice(3);\n    const subparts = deserializeSubparts(rawSubparts, subpartKeys);\n\n    const biotype = biotypeKeys[biotypeCompressed];\n\n    // E.g. ACE2-201, protein_coding, -, <array of exon or UTR arrays>\n    const feature = {\n      name,\n      biotype,\n      strand,\n      subparts\n    };\n\n    if (gene in featuresByGene) {\n      featuresByGene[gene].push(feature);\n    } else {\n      featuresByGene[gene] = [feature];\n    }\n\n  };\n  const t1 = performance.now();\n  perfTimes.parseCacheLoop = Math.round(t1 - t0);\n\n  return featuresByGene;\n}\n\n// Uncomment when workers work outside localhost\n// addEventListener('message', async event => {\n//   console.time('geneStructureCacheWorker');\n//   const [cacheUrl, perfTimes, debug] = event.data;\n//   const result = await fetchAndParse(cacheUrl, perfTimes, parseCache);\n//   postMessage(result);\n//   if (debug) inspectWorker('geneStructure', result[0]);\n// });\n","import {fetchAndParse, inspectWorker, getFullId} from './cache-lib';\n\n/** Parse compressed protein to more easily computable format */\nfunction deserializeProtein(rawProtein, domainKeys) {\n  const domains = [];\n  for (let i = 0; i < rawProtein.length; i++) {\n    const rawDomain = rawProtein[i].split(';');\n    // const domainID = getFullId('IPR', rawDomain[0], 6);\n    const domainName = domainKeys[rawDomain[0]];\n    const start = parseInt(rawDomain[1]);\n    const length = parseInt(rawDomain[2]);\n    const domain = [domainName, start, length];\n    domains.push(domain);\n  }\n  return domains;\n}\n\n/** Parse metainformation header lines, i.e. those beginning  \"## \"\" */\nfunction parseMetainformationHeader(line) {\n  const splitHead = line.split(' keys: ');\n  if (splitHead.length < 2) return [null];\n  const metaHeader = splitHead[0].split('## ')[1];\n  const keys = {};\n  splitHead[1].split('; ').forEach(entry => {\n    const splitEntry = entry.split(' = ');\n    keys[splitEntry[0]] = splitEntry[1];\n  });\n  return [metaHeader, keys];\n}\n\n/** Parse a protein cache TSV file, return array of useful transforms */\nexport function parseCache(rawTsv, perfTimes) {\n  const featuresByGene = {};\n\n  let t0 = performance.now();\n  const lines = rawTsv.split(/\\r\\n|\\n/);\n  perfTimes.rawTsvSplit = Math.round(performance.now() - t0);\n\n  let domainKeys;\n\n  t0 = performance.now();\n\n  let gene = null;\n  let refTxBaseNum;\n  for (let i = 0; i < lines.length; i++) {\n    const line = lines[i];\n    if (line === '') continue; // Skip empty lines\n\n    // Parse header\n    if (line[0] === '#') {\n\n      // Parse metainformation headers\n      if (line[1] === '#') {\n        const [metaHeader, keys] = parseMetainformationHeader(line);\n        if (metaHeader === 'domain') {\n          domainKeys = keys;\n        }\n      }\n      continue;\n    }\n    const splitLine = line.trim().split(/\\t/);\n\n    let transcriptName = splitLine[0];\n    if (isNaN(transcriptName)) {\n      const splitTxName = transcriptName.split('-');\n      const txNum = splitTxName.slice(-1)[0]; // e.g. 208 in ACE2-208\n      const highestDigit = parseInt(txNum[0]); // e.g. 2 in 208\n      const numDigits = txNum.length;\n      refTxBaseNum = highestDigit * (10 ** (numDigits - 1));\n      gene = splitTxName.slice(0, -1).join('-');\n    } else {\n      transcriptName = refTxBaseNum + parseInt(transcriptName);\n      transcriptName = gene + '-' + transcriptName;\n    }\n\n    const rawProtein = splitLine.slice(1);\n    const protein = deserializeProtein(rawProtein, domainKeys);\n\n    // E.g. ACE2-201, <array of proteins <protein name, protein ID, start, length>>\n    const feature = {\n      transcriptName,\n      protein\n    };\n\n    if (gene in featuresByGene) {\n      featuresByGene[gene].push(feature);\n    } else {\n      featuresByGene[gene] = [feature];\n    }\n\n  };\n  const t1 = performance.now();\n  perfTimes.parseCacheLoop = Math.round(t1 - t0);\n\n  return featuresByGene;\n}\n\n// Uncomment when workers work outside localhost\n// addEventListener('message', async event => {\n//   console.time('proteinCacheWorker');\n//   const [cacheUrl, perfTimes, debug] = event.data;\n//   const result = await fetchAndParse(cacheUrl, perfTimes, parseCache);\n//   postMessage(result);\n//   if (debug) inspectWorker('proteinStructure', result[0]);\n// });\n","import {supportsCache, getCacheUrl, fetchAndParse} from './cache-lib';\n\n// Uncomment when workers work outside localhost\n// const geneCacheWorker = new Worker(\n//   new URL('./gene-cache-worker.js', import.meta.url), {type: 'module'}\n// );\n// const paralogCacheWorker = new Worker(\n//   new URL('./paralog-cache-worker.js', import.meta.url), {type: 'module'}\n// );\n// const interactionCacheWorker = new Worker(\n//   new URL('./interaction-cache-worker.js', import.meta.url), {type: 'module'}\n// );\n// const geneStructureCacheWorker = new Worker(\n//   new URL('./gene-structure-cache-worker.js', import.meta.url), {type: 'module'}\n// );\n\nimport {parseCache as parseGeneCache} from './gene-cache-worker';\nimport {parseCache as parseParalogCache} from './paralog-cache-worker';\nimport {parseCache as parseInteractionCache} from './interaction-cache-worker';\nimport {\n  parseCache as parseGeneStructureCache\n} from './gene-structure-cache-worker';\nimport {parseCache as parseProteinCache} from './protein-cache-worker';\n\n/**\n * Populates in-memory content caches from on-disk service worker (SW) caches.\n *\n * This warms the following content caches:\n * - Gene cache: gene symbol -> full name, Ensembl ID, genomic coordinates\n * - Paralog cache: gene symbol -> paralogs (evolutionarily related genes)\n * - Interaction cache: gene symbol -> adjacent genes in biochemical pathways\n *\n * And, optionally:\n * - Gene structure cache: gene symbol -> canonical transcript, exons, UTRs\n *\n * Used for related genes kit now, likely worth generalizing in the future.\n *\n * This approach makes navigating related genes ideogram instant and\n * possible completely offline (i.e. a progressive web component) -- but only\n * once caches are populated.\n */\nexport async function initCaches(ideo) {\n\n  const config = ideo.config;\n  if (!config.useCache) return;\n\n  const organism = config.organism;\n\n  let cacheDir = null;\n  if (config.cacheDir) cacheDir = config.cacheDir;\n\n  if (config.awaitCache) {\n    // Start all these in parallel.  Only initGeneCache blocks; it internally\n    // resolves a Promise, whereas the others return upon completing their\n    // respective initializations.\n    const cachePromise = Promise.all([\n      cacheFactory('gene', organism, ideo, cacheDir),\n      cacheFactory('paralog', organism, ideo, cacheDir),\n      cacheFactory('interaction', organism, ideo, cacheDir)\n    ]);\n\n    if (config.showGeneStructureInTooltip) {\n      cacheFactory('geneStructure', organism, ideo, cacheDir);\n      cacheFactory('protein', organism, ideo, cacheDir);\n    }\n\n    return cachePromise;\n\n  } else {\n    cacheFactory('gene', organism, ideo, cacheDir);\n    cacheFactory('paralog', organism, ideo, cacheDir);\n    cacheFactory('interaction', organism, ideo, cacheDir);\n    if (config.showGeneStructureInTooltip) {\n      cacheFactory('geneStructure', organism, ideo, cacheDir);\n      cacheFactory('protein', organism, ideo, cacheDir);\n    }\n  }\n}\n\nconst allCacheProps = {\n  gene: {\n    metadata: 'Gene', dir: 'genes',\n    fn: setGeneCache,\n    // worker: geneCacheWorker // Uncomment when workers work\n    parseFn: parseGeneCache // Remove when workers work\n  },\n  paralog: {\n    metadata: 'Paralog', dir: 'paralogs',\n    fn: setParalogCache,\n    // worker: paralogCacheWorker // Uncomment when workers work\n    parseFn: parseParalogCache // Remove when workers work\n  },\n  interaction: {\n    metadata: 'Interaction', dir: 'interactions',\n    fn: setInteractionCache, extension: 'json',\n    // worker: interactionCacheWorker, // Uncomment when workers work\n    parseFn: parseInteractionCache // Remove when workers work\n  },\n  geneStructure: {\n    metadata: 'GeneStructure', dir: 'gene-structures-all',\n    fn: setGeneStructureCache,\n    // worker: geneStructureCacheWorker // Uncomment when workers work\n    parseFn: parseGeneStructureCache // Remove when workers work\n  },\n  protein: {\n    metadata: 'Protein', dir: 'proteins',\n    fn: setProteinCache,\n    // worker: proteinCacheWorker // Uncomment when workers work\n    parseFn: parseProteinCache // Remove when workers work\n  }\n};\n\nfunction setGeneCache(parsedCache, ideo) {\n  const [\n    interestingNames, nameCaseMap, namesById, fullNamesById,\n    idsByName, lociByName, lociById\n    //, sortedAnnots\n  ] = parsedCache;\n\n  ideo.geneCache = {\n    interestingNames, // Array ordered by general or scholarly interest\n    nameCaseMap, // Maps of lowercase gene names to proper gene names\n    namesById,\n    fullNamesById,\n    idsByName,\n    lociByName, // Object of gene positions, keyed by gene name\n    lociById\n    //, sortedAnnots // Ideogram annotations sorted by genomic position\n  };\n}\n\nfunction setParalogCache(parsedCache, ideo) {\n  const paralogsByName = parsedCache;\n  // Array of paralog Ensembl IDs by (uppercase) gene name\n  ideo.paralogCache = {paralogsByName};\n}\n\nfunction setInteractionCache(parsedCache, ideo) {\n  const interactionsByName = parsedCache;\n  ideo.interactionCache = interactionsByName;\n}\n\nfunction setGeneStructureCache(parsedCache, ideo) {\n  const featuresByGene = parsedCache;\n  ideo.geneStructureCache = featuresByGene;\n}\n\nfunction setProteinCache(parsedCache, ideo) {\n  ideo.proteinCache = parsedCache;\n}\n\nasync function cacheFactory(cacheName, orgName, ideo, cacheDir=null) {\n\n  const cacheProps = allCacheProps[cacheName];\n  const debug = ideo.config.debug;\n\n  /**\n * Fetch cached gene data, transform it usefully, and set it as ideo prop\n */\n  const startTime = performance.now();\n  let perfTimes = {};\n\n  let parsedCache;\n\n  // Skip initialization if files needed to make cache don't exist\n  if (!supportsCache(orgName, cacheProps.metadata)) return;\n\n  const staticProp = cacheName + 'Cache';\n  // Skip initialization if cache is already populated\n  if (Ideogram[staticProp] && Ideogram[staticProp][orgName]) {\n    // Simplify chief use case, i.e. for single organism\n    ideo[staticProp] = Ideogram[staticProp][orgName];\n    return;\n  }\n\n  if (!Ideogram[staticProp]) {\n    Ideogram[staticProp] = {};\n  }\n\n  const extension = cacheProps?.extension ?? 'tsv';\n  const cacheUrl = getCacheUrl(orgName, cacheDir, cacheProps.dir, extension);\n\n  [parsedCache, perfTimes] =\n    await fetchAndParse(cacheUrl, perfTimes, cacheProps.parseFn, orgName);\n\n  // const cacheWorker = cacheProps.worker;\n  if (debug) console.time(`${cacheName}Cache total`);\n  return new Promise(resolve => {\n  //   const message = [cacheUrl, perfTimes, debug];\n  //   if (cacheName === 'interaction') message.push(orgName);\n  //   cacheWorker.postMessage(message);\n  //   cacheWorker.addEventListener('message', event => {\n  //     [parsedCache, perfTimes] = event.data;\n      cacheProps.fn(parsedCache, ideo, orgName);\n      Ideogram[staticProp][orgName] = ideo[staticProp];\n\n      if (debug) {\n        console.timeEnd(`${cacheName}Cache total`);\n        perfTimes.total = Math.round(performance.now() - startTime);\n        const preamble = 'perfTimes in init' + cacheProps.metadata + 'Cache:';\n        console.log(preamble, perfTimes);\n      }\n\n      resolve();\n    // });\n  });\n}\n","import {fetchAndParse, getFullId, inspectWorker} from './cache-lib';\n\n/**\n * Convert pre-annotation arrays to annotation objects\n * sorted by genomic position.\n */\nfunction parseAnnots(preAnnots) {\n  const chromosomes = {};\n\n  for (let i = 0; i < preAnnots.length; i++) {\n    const [chromosome, start, stop, ensemblId, gene] = preAnnots[i];\n\n    if (!(chromosome in chromosomes)) {\n      chromosomes[chromosome] = {chr: chromosome, annots: []};\n    } else {\n      const annot = {name: gene, start, stop, ensemblId};\n      chromosomes[chromosome].annots.push(annot);\n    }\n  }\n\n  const annotsSortedByPosition = {};\n\n  Object.entries(chromosomes).forEach(([chr, annotsByChr]) => {\n    annotsSortedByPosition[chr] = {\n      chr,\n      annots: annotsByChr.annots.sort((a, b) => a.start - b.start)\n    };\n  });\n\n  return annotsSortedByPosition;\n}\n\n/** Parse a gene cache TSV file, return array of useful transforms */\nexport function parseCache(rawTsv, perfTimes) {\n  const names = [];\n  const nameCaseMap = {};\n  const namesById = {};\n  const fullNamesById = {};\n  const idsByName = {};\n  const lociByName = {};\n  const lociById = {};\n  const preAnnots = [];\n  let ensemblPrefix;\n\n  let t0 = performance.now();\n  const lines = rawTsv.split(/\\r\\n|\\n/);\n  perfTimes.rawTsvSplit = Math.round(performance.now() - t0);\n\n  t0 = performance.now();\n  for (let i = 0; i < lines.length; i++) {\n    const line = lines[i];\n    if (line === '') continue; // Skip empty lines\n    if (line[0] === '#') {\n      if (line.slice(0, 9) === '## prefix') {\n        ensemblPrefix = line.split('prefix: ')[1];\n      }\n      continue;\n    }\n    const [\n      chromosome, rawStart, rawLength, slimEnsemblId, gene\n      , rawFullName\n    ] = line.trim().split(/\\t/);\n    const fullName = decodeURIComponent(rawFullName);\n    const start = parseInt(rawStart);\n    const stop = start + parseInt(rawLength);\n    const ensemblId = getFullId(ensemblPrefix, slimEnsemblId);\n    preAnnots.push([chromosome, start, stop, ensemblId, gene, fullName]);\n    const locus = [chromosome, start, stop];\n\n    names.push(gene);\n    nameCaseMap[gene.toLowerCase()] = gene;\n    namesById[ensemblId] = gene;\n    fullNamesById[ensemblId] = fullName;\n    idsByName[gene] = ensemblId;\n    lociByName[gene] = locus;\n    lociById[ensemblId] = locus;\n  };\n  const t1 = performance.now();\n  perfTimes.parseCacheLoop = Math.round(t1 - t0);\n\n  // const sortedAnnots = parseAnnots(preAnnots);\n  perfTimes.parseAnnots = Math.round(performance.now() - t1);\n\n  return [\n    names, nameCaseMap, namesById,\n    fullNamesById,\n    idsByName, lociByName, lociById\n    // , sortedAnnots\n  ];\n}\n\n// Uncomment when workers work outside localhost\n// addEventListener('message', async event => {\n//   console.time('geneCacheWorker');\n//   // console.log('in gene cache worker message handler');\n//   const [cacheUrl, perfTimes, debug] = event.data;\n//   const result = await fetchAndParse(cacheUrl, perfTimes, parseCache);\n//   postMessage(result);\n//   if (debug) inspectWorker('gene', result[0]);\n// });\n","import {fetchAndParse, getFullId, inspectWorker} from './cache-lib';\n\n/** Parse a paralog cache TSV file, return array of useful transforms */\nexport function parseCache(rawTsv, perfTimes) {\n  const paralogsByName = {};\n  let ensemblPrefix;\n\n  let t0 = performance.now();\n  const lines = rawTsv.split(/\\r\\n|\\n/);\n  perfTimes.rawTsvSplit = Math.round(performance.now() - t0);\n\n  t0 = performance.now();\n  for (let i = 0; i < lines.length; i++) {\n    const line = lines[i];\n    if (line === '') continue; // Skip empty lines\n    if (line[0] === '#') {\n      if (line.slice(0, 9) === '## prefix') {\n        ensemblPrefix = line.split('prefix: ')[1];\n      }\n      continue;\n    }\n    const columns = line.trim().split(/\\t/);\n    const gene = columns[0];\n    const geneSlimId = columns[1];\n\n    const paralogs = [];\n    if (columns[2][0] === '_') {\n      const pointer = columns[2].slice(1).toUpperCase();\n      const paralogSuperList = paralogsByName[pointer];\n      const geneId = getFullId(ensemblPrefix, geneSlimId);\n      for (let j = 0; j < paralogSuperList.length; j++) {\n        const id = paralogSuperList[j];\n        if (id !== geneId) {\n          paralogs.push(id);\n        }\n      }\n      paralogs.unshift(getFullId(ensemblPrefix, columns[3]));\n    } else {\n      const slimEnsemblIds = columns.slice(2);\n      for (let j = 0; j < slimEnsemblIds.length; j++) {\n        const slimId = slimEnsemblIds[j];\n        if (slimId !== geneSlimId) {\n          paralogs.push(getFullId(ensemblPrefix, slimId));\n        }\n      }\n    }\n\n    paralogsByName[gene.toUpperCase()] = paralogs;\n  };\n  const t1 = performance.now();\n  perfTimes.parseCacheLoop = Math.round(t1 - t0);\n\n  return paralogsByName;\n}\n\n// Uncomment when workers work outside localhost\n// addEventListener('message', async event => {\n//   console.time('paralogCacheWorker');\n//   const [cacheUrl, perfTimes, debug] = event.data;\n//   const result = await fetchAndParse(cacheUrl, perfTimes, parseCache);\n//   postMessage(result);\n//   if (debug) inspectWorker('paralog', result[0]);\n// });\n","import {fetchAndParse, inspectWorker} from './cache-lib';\n\n/** Parse an interaction cache JSON file, return array of useful transforms */\nexport function parseCache(rawJson, perfTimes, orgName) {\n  let t0 = performance.now();\n  const interactionsByName = {};\n  const tmp = orgName.replace('-', ' ');\n  const desluggedOrg = tmp[0].toUpperCase() + tmp.slice(1);\n\n  t0 = performance.now();\n  for (const gene in rawJson['interactions']) {\n    const ixnLists = rawJson['interactions'][gene];\n    interactionsByName[gene] = {result: []};\n    for (let i = 0; i < ixnLists.length; i++) {\n      const compressedIxn = ixnLists[i];\n      const slimPwId = compressedIxn[0];\n      interactionsByName[gene].result.push({\n        fields: {\n          left: {values: compressedIxn[1]},\n          right: {values: compressedIxn[2]}\n        },\n        id: 'WP' + slimPwId,\n        name: rawJson['pathwayNamesById'][slimPwId],\n        species: desluggedOrg\n      });\n    }\n  }\n  const t1 = performance.now();\n  perfTimes.parseCacheLoop = Math.round(t1 - t0);\n\n  return interactionsByName;\n}\n\n// Uncomment when workers work outside localhost\n// addEventListener('message', async event => {\n//   console.time('interactionCacheWorker');\n//   const [cacheUrl, perfTimes, debug, orgName] = event.data;\n//   const result = await fetchAndParse(cacheUrl, perfTimes, parseCache, orgName);\n//   postMessage(result);\n//   if (debug) inspectWorker('interaction', result[0]);\n// });\n","import {d3} from '../lib';\nimport collinearizeChromosomes from '../collinear';\nimport {initCaches} from './caches/cache';\n\nfunction processLabels(config, ideo) {\n  var i, chrID, t0C, t1C;\n\n  if (config.showBandLabels === true) {\n    t0C = new Date().getTime();\n    ideo.hideUnshownBandLabels();\n    t1C = new Date().getTime();\n    if (config.debug) {\n      console.log('Time in showing bands: ' + (t1C - t0C) + ' ms');\n    }\n\n    if (config.orientation === 'vertical') {\n      for (i = 0; i < ideo.chromosomesArray.length; i++) {\n        chrID = '#' + ideo.chromosomesArray[i].id;\n        ideo.rotateChromosomeLabels(d3.select(chrID), i);\n      }\n    }\n  }\n\n  if (config.showChromosomeLabels === true) {\n    ideo.drawChromosomeLabels(ideo.chromosomes);\n  }\n}\n\nfunction processAnnots(ideo) {\n  if (typeof ideo.timeout !== 'undefined') window.clearTimeout(ideo.timeout);\n\n  ideo.rawAnnots = ideo.setOriginalTrackIndexes(ideo.rawAnnots);\n\n  if (ideo.config.annotationsDisplayedTracks) {\n    ideo.annots =\n      ideo.updateDisplayedTracks(ideo.config.annotationsDisplayedTracks);\n  } else {\n    ideo.annots = ideo.processAnnotData(ideo.rawAnnots);\n    if (ideo.config.filterable) ideo.initCrossFilter();\n    ideo.drawProcessedAnnots(ideo.annots);\n  }\n}\n\n/**\n * Load (potentially large) annotation dataset, then process it.\n */\nfunction waitForAndProcessAnnots(ideo) {\n  if (ideo.rawAnnots) {\n    processAnnots(ideo);\n  } else {\n    (function checkAnnotData() {\n      ideo.timeout = setTimeout(function() {\n        if (\n          !ideo.rawAnnots ||\n          (ideo.rawAnnots && typeof ideo.rawAnnots.then !== 'undefined')\n        ) {\n          // Ensure rawAnnots is defined and not a Promise (not \"then\"-able)\n          checkAnnotData();\n        } else {\n          processAnnots(ideo);\n        }\n      }, 50);\n    })();\n  }\n}\n\nfunction reportDebugTimings(config, t0, t0A) {\n\n  var t1A = new Date().getTime();\n  if (config.debug) {\n    console.log('Time in drawChromosome: ' + (t1A - t0A) + ' ms');\n  }\n\n  var t1 = new Date().getTime();\n  if (config.debug) {\n    console.log('Time constructing ideogram: ' + (t1 - t0) + ' ms');\n  }\n}\n\n/**\n * Completes high-level initialization.\n * Draws chromosomes and band labels, rotating as needed;\n * processes and draws annotations;\n * creates brush, emits notification of load completion, etc.\n */\nfunction finishInit(t0) {\n  var t0A = new Date().getTime(),\n    ideo = this,\n    config = ideo.config,\n    confAnnots = config.annotations;\n\n  ideo.initDrawChromosomes();\n\n  if (config.annotationsPath) waitForAndProcessAnnots(ideo);\n\n  processLabels(config, ideo);\n\n  // Create a brush or a click cursor if specified\n  if (config.brush) ideo.createBrush(config.brush);\n  else if (config.cursorPosition) ideo.createClickCursor(config.cursorPosition);\n\n  if (confAnnots) {\n    if (Array.isArray(confAnnots)) {\n      ideo.drawAnnots(confAnnots);\n    } else {\n      // Enable client-side-defined annotations to be formatted\n      // like the wider variety of server-side-defined annotations.\n      // Supports https://github.com/eweitz/ideogram/issues/137\n      ideo.rawAnnots = confAnnots;\n      ideo.afterRawAnnots();\n      processAnnots(ideo);\n    }\n  }\n\n  reportDebugTimings(config, t0, t0A);\n\n  ideo.setOverflowScroll();\n\n  if (config.geometry === 'collinear') collinearizeChromosomes(ideo);\n\n  if (ideo.config.debug) console.time('initCache: Ideogram');\n  initCaches(ideo).then(() => {\n    if (ideo.config.debug) console.timeEnd('initCache: Ideogram');\n    if (ideo.onLoadCallback) ideo.onLoadCallback();\n  });\n}\n\nexport {finishInit};\n","export class Ploidy {\n\n  constructor(config) {\n    this._config = config;\n    this._description = this._normalize(this._config.ploidyDesc);\n  }\n\n  // Get number of chromosomes in a chromosome set\n  getChromosomesNumber(setIndex) {\n    if (this._config.ploidyDesc) {\n      var chrSetCode = this._config.ploidyDesc[setIndex];\n      if (chrSetCode instanceof Object) {\n        return Object.keys(chrSetCode)[0].length;\n      } else {\n        return chrSetCode.length;\n      }\n    } else {\n      return this._config.ploidy || 1;\n    }\n  }\n\n  // Normalize use defined description\n  _normalize(description) {\n    var key, descValue,\n      normalized = [];\n\n    if (!description) return description;\n\n    // Loop through description and normalize\n    for (key in description) {\n      descValue = description[key];\n      if (typeof descValue === 'string') {\n        if (this._config.orientation === 'vertical') {\n          descValue = descValue.split('').reverse();\n        }\n        normalized.push({\n          ancestors: descValue,\n          existence: this._getexistenceArray(descValue.length)\n        });\n      } else {\n        normalized.push({\n          ancestors: Object.keys(descValue)[0],\n          existence: descValue[Object.keys(descValue)[0]]\n        });\n      }\n    }\n\n    return normalized;\n  }\n\n  // Get array filled by '11' elements\n  _getexistenceArray(length) {\n    var array = [];\n\n    for (var i = 0; i < length; i++) {\n      array.push('11');\n    }\n\n    return array;\n  }\n\n  getSetSize(chrSetIndex) {\n    if (this._description) {\n      return this._description[chrSetIndex].ancestors.length;\n    } else {\n      return 1;\n    }\n  }\n\n  // Get ancestor letter\n  getAncestor(chrSetIndex, chrIndex) {\n    if (this._description) {\n      return this._description[chrSetIndex].ancestors[chrIndex];\n    } else {\n      return '';\n    }\n  }\n\n  // Check if chromosome's arm should be rendered.\n  // If no description was provided, method returns true and\n  // something another depending on user provided description.\n  exists(chrSetIndex, chrIndex, armIndex) {\n    if (this._description) {\n      var desc =\n        this._description[chrSetIndex].existence[chrIndex][armIndex];\n      return Number(desc) > 0;\n    } else {\n      return true;\n    }\n  }\n\n}\n","import {d3} from '../lib';\n\n/**\n * Chromosome's view utility class\n */\nexport class ChromosomeUtil {\n\n  constructor(node) {\n    this._node = node;\n  }\n\n  getLabel() {\n    var label =\n      d3\n        .select(this._node.parentNode)\n        .select('text.chrLabel')\n        .text();\n    return label;\n  }\n\n  /**\n   * Get chromosome set label\n   */\n  getSetLabel() {\n    var setLabel =\n      d3\n        .select(this._node.parentNode)\n        .select('text.chrSetLabel')\n        .text();\n    return setLabel;\n  }\n}\n","import {d3} from '../lib';\nimport {ChromosomeUtil} from './../views/chromosome-util';\n\nclass Layout {\n\n  constructor(config, ideo) {\n    this._config = config;\n    this._ideo = ideo;\n    this._ploidy = this._ideo._ploidy;\n    this._translate = undefined;\n\n    if ('chrSetMargin' in config) {\n      this.chrSetMargin = config.chrSetMargin;\n    } else {\n      var chrMargin = this._config.chrMargin;\n      this.chrSetMargin = (this._config.ploidy > 1 ? chrMargin : 0);\n    }\n\n    // Chromosome band's size.\n    this._tickSize = 8;\n\n    // Chromosome rotation state.\n    this._isRotated = false;\n  }\n\n  // Get chart left margin\n  _getLeftMargin() {\n    return this.margin.left;\n  }\n\n  // Get rotated chromosome y scale\n  _getYScale() {\n    // 20 is width of rotated chromosome.\n    return 20 / this._config.chrWidth;\n  }\n\n  // Get chromosome labels\n  getChromosomeLabels(chrElement) {\n    var util = new ChromosomeUtil(chrElement),\n      labels = [];\n\n    if (this._ideo.config.ploidy > 1) {\n      labels.push(util.getSetLabel());\n    }\n    labels.push(util.getLabel());\n\n    return labels.filter(function(d) {\n      return d.length > 0;\n    });\n  }\n\n  getChromosomeBandLabelTranslate(band) {\n    var x, y, translate,\n      ideo = this._ideo,\n      tickSize = this._tickSize,\n      orientation = ideo.config.orientation;\n\n    if (orientation === 'vertical') {\n      x = tickSize;\n      y = ideo.round(2 + band.px.start + band.px.width / 2);\n      translate = 'rotate(-90)translate(' + x + ',' + y + ')';\n    } else if (orientation === 'horizontal') {\n      x = ideo.round(-tickSize + band.px.start + band.px.width / 2);\n      y = -10;\n      translate = 'translate(' + x + ',' + y + ')';\n    }\n\n    return {\n      x: x,\n      y: y,\n      translate: translate\n    };\n  }\n\n  didRotate(chrIndex, chrElement) {\n    var ideo, taxid, chrName, bands, chrModel, oldWidth,\n      chrSetElement, transform, scale, scaleRE;\n\n    ideo = this._ideo;\n    taxid = ideo.config.taxid;\n    chrName = chrElement.id.split('-')[0].replace('chr', '');\n    chrModel = ideo.chromosomes[taxid][chrName];\n    bands = chrModel.bands;\n\n    chrSetElement = d3.select(chrElement.parentNode);\n    transform = chrSetElement.attr('transform');\n    scaleRE = /scale\\(.*\\)/;\n    scale = scaleRE.exec(transform);\n    transform = transform.replace(scale, '');\n    chrSetElement.attr('transform', transform);\n\n    oldWidth = chrModel.width;\n\n    chrModel = ideo.getChromosomeModel(bands, chrName, taxid, chrIndex);\n\n    chrModel.oldWidth = oldWidth;\n\n    ideo.chromosomes[taxid][chrName] = chrModel;\n    ideo.drawChromosome(chrModel);\n\n    ideo.handleRotateOnClick();\n\n    if (ideo.rawAnnots) {\n      if (ideo.displayedTrackIndexes) {\n        ideo.updateDisplayedTracks(ideo.displayedTrackIndexes);\n      } else {\n        ideo.annots = ideo.processAnnotData(ideo.rawAnnots);\n        ideo.drawProcessedAnnots(ideo.annots);\n\n        if (ideo.config.filterable) {\n          ideo.initCrossFilter();\n        }\n      }\n    }\n\n    if (ideo.config.showBandLabels === true) {\n      ideo.drawBandLabels(ideo.chromosomes);\n      ideo.hideUnshownBandLabels();\n    }\n\n    if (ideo.onDidRotateCallback) {\n      ideo.onDidRotateCallback(chrModel);\n    }\n  }\n\n  rotate(chrSetIndex, chrIndex, chrElement) {\n    var ideo, otherChrs, ideoBounds, labelSelectors;\n    ideo = this._ideo;\n\n    labelSelectors = (\n      ideo.selector + ' .chrSetLabel, ' + ideo.selector + ' .chrLabel'\n    );\n\n    ideoBounds = document.querySelector(ideo.selector).getBoundingClientRect();\n\n    // Find chromosomes which should be hidden\n    otherChrs = d3.selectAll(ideo.selector + ' g.chromosome')\n      .filter(function() {return this !== chrElement;});\n\n    if (this._isRotated) {\n\n      this._isRotated = false;\n\n      ideo.config.chrHeight = ideo.config.chrHeightOriginal;\n      ideo.config.chrWidth = ideo.config.chrWidthOriginal;\n      ideo.config.annotationHeight = ideo.config.annotationHeightOriginal;\n\n      // Rotate chromosome back\n      this.rotateBack(chrSetIndex, chrIndex, chrElement, function() {\n        // Show all other chromosomes and chromosome labels\n        otherChrs.style('display', null);\n        d3.selectAll(labelSelectors).style('display', null);\n        ideo._layout.didRotate(chrIndex, chrElement);\n      });\n\n    } else {\n\n      this._isRotated = true;\n\n      // Hide all other chromosomes and chromosome labels\n      otherChrs.style('display', 'none');\n      d3.selectAll(labelSelectors).style('display', 'none');\n\n      // Rotate chromosome\n      this.rotateForward(chrSetIndex, chrIndex, chrElement, function() {\n\n        var chrHeight, elementLength, windowLength;\n\n        ideo.config.chrHeightOriginal = ideo.config.chrHeight;\n        ideo.config.chrWidthOriginal = ideo.config.chrWidth;\n        ideo.config.annotationHeightOriginal = ideo.config.annotationHeight;\n\n        const settingsGearWidth = 20;\n\n        if (ideo._layout._class === 'VerticalLayout') {\n          elementLength = ideoBounds.width - settingsGearWidth;\n          windowLength = window.innerWidth - settingsGearWidth;\n        } else {\n          elementLength = ideoBounds.height - 10;\n          windowLength = window.innerHeight - 10;\n        }\n\n        // Set chromosome height to window length or ideogram element length,\n        // whichever is smaller.  This keeps whole chromosome viewable, while\n        // also ensuring the height doesn't exceed what the user specified.\n        if (windowLength < elementLength) {\n          chrHeight = windowLength;\n        } else {\n          chrHeight = elementLength;\n        }\n        chrHeight -= ideo.config.chrMargin * 2;\n        ideo.config.chrHeight = chrHeight;\n\n        // Account for chromosome label\n        // TODO: Make this dynamic, not hard-coded\n        ideo.config.chrWidth *= 2.3;\n\n        ideo.config.annotationHeight *= 1.7;\n\n        ideo._layout.didRotate(chrIndex, chrElement);\n      });\n    }\n  }\n\n  getChromosomeLabelClass() {\n    if (this._config.ploidy === 1) {\n      return 'chrLabel';\n    } else {\n      return 'chrSetLabel';\n    }\n  }\n\n  _getAdditionalOffset() {\n    var config = this._config;\n    var numTracks = config.annotationsNumTracks || config.numAnnotTracks || 1;\n    return (config.annotationHeight || 0) * numTracks;\n  }\n\n  _getChromosomeSetSize(chrSetIndex) {\n    // Get last chromosome set size.\n    var setSize = this._ploidy.getSetSize(chrSetIndex);\n\n    // Increase offset by last chromosome set size\n    return (\n      setSize * this._config.chrWidth * 2 + (this.chrSetMargin)\n    );\n  }\n\n  // Get chromosome set label anchor property\n  getChromosomeSetLabelAnchor() {\n    return 'middle';\n  }\n\n  // Get chromosome label y position.\n  getChromosomeLabelYPosition() {\n    return -5.5;\n  }\n\n  getChromosomeSetLabelYPosition(chrIndex) {\n    if (this._config.ploidy === 1) {\n      return this.getChromosomeLabelYPosition(chrIndex);\n    } else {\n      return -2 * this._config.chrWidth;\n    }\n  }\n\n}\n\nexport default Layout;\n","/**\n* @fileoverview Vertical layout class\n* Ideogram instances with vertical layout are oriented with each chromosome\n* starting at top and ending at bottom, and aligned as columns.\n*/\n\nimport {d3} from '../lib';\nimport Layout from './layout';\n\nclass VerticalLayout extends Layout {\n\n  constructor(config, ideo) {\n    super(config, ideo);\n    this._class = 'VerticalLayout';\n    // Layout margins\n    this.margin = {\n      top: 30,\n      left: 15\n    };\n  }\n\n  rotateForward(chrSetIndex, chrIndex, chrElement, callback) {\n    // TODO: Integrate chrSetIndex and chrIndex to support polyploid rotation.\n\n    var self = this;\n\n    var xOffset = 20;\n\n    var scale = this.getChromosomeScale(chrElement);\n\n    var transform =\n      'translate(' + xOffset + ', 25) ' + scale;\n\n    d3.select(chrElement.parentNode)\n      .transition()\n      .attr('transform', transform)\n      .on('end', callback);\n\n    // Append new chromosome labels\n    var labels = this.getChromosomeLabels(chrElement);\n    var y = (xOffset + self._config.chrWidth) * 1.3;\n    d3.select(this._ideo.getSvg())\n      .append('g')\n      .attr('class', 'tmp')\n      .selectAll('text')\n      .data(labels)\n      .enter()\n      .append('text')\n      .attr('class', function(d, i) {\n        return i === 0 && labels.length === 2 ? 'chrSetLabel' : null;\n      })\n      .attr('x', 0)\n      .attr('y', y).style('opacity', 0)\n      .text(String)\n      .transition()\n      .style('opacity', 1);\n\n    this._ideo.config.orientation = 'horizontal';\n  }\n\n  rotateBack(setIndex, chrIndex, chrElement, callback) {\n\n    var scale = this.getChromosomeScaleBack(chrElement);\n    var translate = this.getChromosomeSetTranslate(setIndex);\n\n    d3.select(chrElement.parentNode)\n      .transition()\n      .attr('transform', translate + ' ' + scale)\n      .on('end', callback);\n\n    d3.selectAll(this._ideo.selector + ' g.tmp')\n      .style('opacity', 0)\n      .remove();\n\n    this._ideo.config.orientation = 'vertical';\n  }\n\n  getHeight() {\n    return this._config.chrHeight + this.margin.top * 1.5;\n  }\n\n  getWidth() {\n    return '97%';\n  }\n\n  getChromosomeBandTickY1() {\n    return 2;\n  }\n\n  getChromosomeBandTickY2() {\n    return 10;\n  }\n\n  getChromosomeSetLabelTranslate() {\n    return 'rotate(-90)';\n  }\n\n  getChromosomeBandLabelAnchor() {\n    return null;\n  }\n\n  getChromosomeScale(chrElement) {\n    var ideoBox, chrBox, scaleX, scaleY;\n\n    ideoBox = d3.select(this._ideo.selector).node().getBoundingClientRect();\n    chrBox = chrElement.getBoundingClientRect();\n\n    scaleX = (ideoBox.width / chrBox.height) * 0.97;\n    scaleY = this._getYScale();\n\n    return 'scale(' + scaleX + ', ' + scaleY + ')';\n  }\n\n  getChromosomeScaleBack(chrElement) {\n    var scale, scaleX, scaleY, chrName, chrModel, taxid, ideo, config;\n\n    ideo = this._ideo;\n    config = ideo.config;\n    taxid = config.taxid;\n\n    chrName = chrElement.id.split('-')[0].replace('chr', '');\n    chrModel = this._ideo.chromosomes[taxid][chrName];\n    scaleX = (chrModel.oldWidth / (config.chrHeight * 3)) * 0.97;\n    scaleY = 1 / this._getYScale();\n    scale = 'scale(' + scaleX + ', ' + scaleY + ')';\n    return scale;\n  }\n\n  getChromosomeSetTranslate(setIndex) {\n    var marginTop = this.margin.top;\n    var chromosomeSetYTranslate = this.getChromosomeSetYTranslate(setIndex);\n    return (\n      'rotate(90) ' +\n      'translate(' + marginTop + ', -' + chromosomeSetYTranslate + ')'\n    );\n  }\n\n  getChromosomeSetYTranslate(setIndex) {\n    // Get additional padding caused by annotation/histogram tracks\n    var pad = this._getAdditionalOffset(),\n      config = this._config,\n      margin = config.chrMargin,\n      width = config.chrWidth,\n      translate;\n\n    // If no detailed description provided just use one formula for all cases\n    if (!config.ploidyDesc) {\n      // TODO:\n      // This part of code contains a lot magic numbers and if\n      // statements for exactly corresponing to original ideogram examples.\n      // But all this stuff should be removed. Calculation of translate\n      // should be a simple formula applied for all cases listed below.\n      // Now they are diffirent because of Layout:_getAdditionalOffset do\n      // not meet for cases when no annotation, when annotation exists and\n      // when histogram used\n\n      if (config.annotationsLayout === 'histogram') {\n        var barWidth = config.barWidth;\n        return margin + setIndex * (margin + width + 3) + barWidth * 2;\n      } else {\n        const decorPad =\n          'legendPad' in config ? config.legendPad : 0;\n        translate = width + setIndex * (margin + width) + pad * 2 + decorPad;\n        if (pad > 0) {\n          return translate;\n        } else {\n          return translate + 4 + (2 * setIndex);\n        }\n      }\n    }\n\n    // If detailed description provided start to calculate offsets\n    // for each chromosome set separately. This should be done only once\n    if (!this._translate) {\n      // First offset equals to zero\n      this._translate = [this._ploidy.getSetSize(0) * width * 2];\n      var prevTranslate;\n      // Loop through description set\n      for (var i = 1; i < this._config.ploidyDesc.length; i++) {\n        prevTranslate = this._translate[i - 1];\n        this._translate[i] = prevTranslate + this._getChromosomeSetSize(i - 1);\n      }\n    }\n\n    return this._translate[setIndex];\n  }\n\n  getChromosomeSetLabelXPosition() {\n    return (this._config.chrWidth * this._config.ploidy) / -2;\n  }\n\n  getChromosomeLabelXPosition() {\n    return this._config.chrWidth / -2;\n  }\n}\n\nexport default VerticalLayout;\n","/**\n* @fileoverview Horizontal layout class\n* Ideogram instances with horizontal layout are oriented with each chromosome\n* starting at left and ending at right, and aligned as rows.\n*/\n\nimport {d3} from '../lib';\nimport Layout from './layout';\n\nclass HorizontalLayout extends Layout {\n\n  constructor(config, ideo) {\n    super(config, ideo);\n    this._class = 'HorizontalLayout';\n    this.margin = {\n      left: 20,\n      top: 30\n    };\n  }\n\n  _getLeftMargin() {\n    var margin = Layout.prototype._getLeftMargin.call(this);\n    if (this._config.ploidy > 1) {\n      margin *= 1.8;\n    }\n\n    return margin;\n  }\n\n  rotateForward(setIndex, chrIndex, chrElement, callback) {\n\n    var xOffset, yOffset, transform, labels;\n\n    xOffset = 30;\n\n    yOffset = xOffset + 7.5;\n\n    transform = (\n      'rotate(90) ' +\n      'translate(' + xOffset + ', -' + yOffset + ') '\n    );\n\n    d3.select(chrElement.parentNode)\n      .transition()\n      .attr('transform', transform)\n      .on('end', callback);\n\n    // Append new chromosome labels\n    labels = this.getChromosomeLabels(chrElement);\n    d3.select(this._ideo.getSvg())\n      .append('g')\n      .attr('class', 'tmp')\n      .selectAll('text')\n      .data(labels)\n      .enter()\n      .append('text')\n      .attr('class', function(d, i) {\n        return i === 0 && labels.length === 2 ? 'chrSetLabel' : null;\n      })\n      .attr('x', xOffset - 4)\n      .attr('y', function(d, i) {\n        return (i + 1 + labels.length % 2) * 12;\n      })\n      .style('text-anchor', 'middle')\n      .style('opacity', 0)\n      .text(String)\n      .transition()\n      .style('opacity', 1);\n\n    this._ideo.config.orientation = 'vertical';\n  }\n\n  rotateBack(setIndex, chrIndex, chrElement, callback) {\n    var translate = this.getChromosomeSetTranslate(setIndex);\n\n    d3.select(chrElement.parentNode)\n      .transition()\n      .attr('transform', translate)\n      .on('end', callback);\n\n    d3.selectAll(this._ideo.selector + ' g.tmp')\n      .style('opacity', 0)\n      .remove();\n\n    this._ideo.config.orientation = 'horizontal';\n  }\n\n  getHeight(taxid) {\n    if (typeof taxid === 'undefined') taxid = this._config.taxids[0];\n    // Get last chromosome set offset.\n    var numChromosomes = this._config.chromosomes[taxid].length;\n    var lastSetOffset = this.getChromosomeSetYTranslate(numChromosomes - 1);\n\n    // Get last chromosome set size.\n    var lastSetSize = this._getChromosomeSetSize(numChromosomes - 1);\n\n    // Increase offset by last chromosome set size\n    lastSetOffset += lastSetSize;\n\n    return lastSetOffset + this._getAdditionalOffset() * 2;\n  }\n\n  getWidth() {\n    return this._config.chrHeight + this.margin.top * 1.5;\n  }\n\n  getChromosomeSetLabelAnchor() {\n    return 'end';\n  }\n\n  getChromosomeBandLabelAnchor() {\n    return null;\n  }\n\n  getChromosomeBandTickY1() {\n    return 2;\n  }\n\n  getChromosomeBandTickY2() {\n    return 10;\n  }\n\n  getChromosomeSetLabelTranslate() {\n    return null;\n  }\n\n  getChromosomeSetTranslate(setIndex) {\n    var leftMargin = this._getLeftMargin();\n    var yTranslate = this.getChromosomeSetYTranslate(setIndex);\n    return 'translate(' + leftMargin + ', ' + yTranslate + ')';\n  }\n\n  getChromosomeSetYTranslate(setIndex) {\n    // If no detailed description provided just use one formula for all cases.\n    if (!this._config.ploidyDesc) {\n      return this._config.chrMargin * (setIndex + 1);\n    }\n\n    // Id detailed description provided start to calculate offsets\n    //  for each chromosome set separately. This should be done only once.\n    if (!this._translate) {\n      // First offset equals to zero.\n      this._translate = [1];\n\n      // Loop through description set\n      for (var i = 1; i < this._config.ploidyDesc.length; i++) {\n        this._translate[i] =\n          this._translate[i - 1] + this._getChromosomeSetSize(i - 1);\n      }\n    }\n\n    return this._translate[setIndex];\n  }\n\n  getChromosomeSetLabelXPosition(i) {\n    if (this._config.ploidy === 1) {\n      return this.getChromosomeLabelXPosition(i);\n    } else {\n      return -20;\n    }\n  }\n\n  getChromosomeSetLabelYPosition(i) {\n    var setSize = this._ploidy.getSetSize(i),\n      config = this._config,\n      chrMargin = config.chrMargin,\n      chrWidth = config.chrWidth,\n      y;\n\n    if (config.ploidy === 1) {\n      y = chrWidth / 2 + 3;\n    } else {\n      y = (setSize * chrMargin) / 2;\n    }\n\n    return y;\n  }\n\n  getChromosomeLabelXPosition() {\n    return -8;\n  }\n\n  getChromosomeLabelYPosition() {\n    return this._config.chrWidth;\n  }\n\n}\n\nexport default HorizontalLayout;\n","/**\n* @fileoverview Paired layout class\n* Ideograms with paired layout group each chromosome in a chromosome set.\n* This enables ploidy support beyond the default haploid; e.g. diploid genomes.\n*/\n\nimport Layout from './layout';\n\nclass PairedLayout extends Layout {\n\n  constructor(config, ideo) {\n    super(config, ideo);\n\n    this._class = 'PairedLayout';\n\n    this.margin = {\n      left: 30\n    };\n  }\n\n  getHeight() {\n    return this._config.chrHeight + this.margin.left * 1.5;\n  }\n\n  getWidth() {\n    return '97%';\n  }\n\n  getChromosomeBandTickY1(chrIndex) {\n    return chrIndex % 2 ? this._config.chrWidth : this._config.chrWidth * 2;\n  }\n\n  getChromosomeBandTickY2(chrIndex) {\n    var width = this._config.chrWidth;\n    return chrIndex % 2 ? width - this._tickSize : width * 2 + this._tickSize;\n  }\n\n  getChromosomeBandLabelAnchor(chrIndex) {\n    return chrIndex % 2 ? null : 'end';\n  }\n\n  getChromosomeBandLabelTranslate(band, chrIndex) {\n    var x = chrIndex % 2 ? 10 : -this._config.chrWidth - 10;\n    var y = this._ideo.round(band.px.start + band.px.width / 2) + 3;\n\n    return {\n      x: y,\n      y: y,\n      translate: 'rotate(-90) translate(' + x + ', ' + y + ')'\n    };\n  }\n\n  getChromosomeLabelXPosition() {\n    return -this._tickSize;\n  }\n\n  getChromosomeSetLabelXPosition() {\n    return this._config.chrWidth / -2;\n  }\n\n  getChromosomeSetLabelTranslate() {\n    return 'rotate(-90)';\n  }\n\n  getChromosomeSetTranslate(setIndex) {\n    var chromosomeSetYTranslate = this.getChromosomeSetYTranslate(setIndex);\n    return (\n      'rotate(90) ' +\n      'translate(' + this.margin.left + ', -' + chromosomeSetYTranslate + ')'\n    );\n  }\n\n  getChromosomeSetYTranslate(setIndex) {\n    return 200 * (setIndex + 1);\n  }\n\n}\n\nexport default PairedLayout;\n","import Layout from './layout';\n\nclass SmallLayout extends Layout {\n\n  constructor(config, ideo) {\n    super(config, ideo);\n\n    this._class = 'SmallLayout';\n\n    this.margin = {\n      left: 36.5,\n      top: 10\n    };\n\n    var taxid = this._ideo.getTaxid(this._ideo.config.organism);\n\n    this.chrs = config.chromosomes[taxid];\n    var numChrs = this.chrs.length;\n\n    // Number of chromosomes per row\n    this.chrsPerRow = Math.ceil(numChrs / config.rows);\n  }\n\n  // rotateForward(setIndex, chrIndex, chrElement, callback) {\n  //   var ideoBox =\n  //      d3.select(this._ideo.selector).node().getBoundingClientRect();\n  //   var chrBox = chrElement.getBoundingClientRect();\n  //\n  //   var scaleX = (ideoBox.width / chrBox.height) * 0.97;\n  //   var scaleY = this._getYScale();\n  //\n  //   transform = 'translate(5, 25) scale(' + scaleX + ', ' + scaleY + ')';\n  //\n  //   d3.select(chrElement.parentNode)\n  //     .transition()\n  //     .attr('transform', transform)\n  //     .on('end', callback);\n  // }\n  //\n  // rotateBack(setIndex, chrIndex, chrElement, callback) {\n  //   var translate = this.getChromosomeSetTranslate(setIndex);\n  //\n  //   d3.select(chrElement.parentNode)\n  //     .transition()\n  //     .attr('transform', translate)\n  //     .on('end', callback);\n  // }\n\n  /**\n   * eweitz 2020-04-13:\n   * This height metric is crude because it is calculated before\n   * the height (\"width\") of each chromosome is calculated.\n   *\n   * It calculates height by multiplying the max height of all chromosomes\n   * (specified in the Ideogram configuration object) by the number of rows.\n   * This ensures the ideogram height doesn't truncate in cases like dog\n   * (where chrX on the second row is longer than chr1 on the first), but it\n   * often leaves too much space on the second row, e.g. for human.\n   *\n   * Ideally, ideogram height would be cumulative height per row, plus top\n   * margin.  This would require calling getHeight _after_ all chromosomes\n   * have had their height (technically, chr.width) assigned.  See draft new\n   * getHeight method below this getHeight method.\n  */\n  getHeight() {\n    var config = this._config;\n    var chrHeight = config.chrHeight * 1.25;\n    return this._config.rows * (chrHeight + this.margin.top);\n  }\n\n  /**\n   * eweitz 2020-04-13:\n   * Draft refinement of getHeight.  See note in classic version above.\n   *\n   * Total height is cumulative height per row, plus top margin\n   */\n  // getHeight() {\n  //   let height = 0;\n  //   const rows = this._config.rows;\n  //   const chrEntries = Object.entries(this.chrs);\n\n  //   for (let i = 0; i < rows; i++) {\n  //     let rowHeight = 0;\n  //     // Starting and ending indexes of chromosomes of this row\n  //     const startIndex = this.chrsPerRow * i;\n  //     const endIndex = this.chrsPerRow * (i + 1) - 1;\n\n  //     for (let j = startIndex; j < endIndex; j++) {\n  //       const thisChrHeight = chrEntries[j][1].width;\n  //       if (thisChrHeight > rowHeight) {\n  //         rowHeight = thisChrHeight;\n  //       }\n  //     }\n  //     height += rowHeight + this.margin.top;\n  //   }\n\n  //   return height;\n  // }\n\n  getWidth() {\n    return '97%';\n  }\n\n  getChromosomeBandLabelTranslate() {\n\n  }\n\n  getChromosomeSetLabelTranslate() {\n    return 'rotate(-90)';\n  }\n\n  getChromosomeSetTranslate(setIndex) {\n    var xOffset, yOffset;\n\n    if (setIndex > this.chrsPerRow - 1) {\n      xOffset = this.margin.left + this._config.chrHeight * 1.3;\n      yOffset = this.getChromosomeSetYTranslate(setIndex - this.chrsPerRow);\n    } else {\n      xOffset = this.margin.left;\n      yOffset = this.getChromosomeSetYTranslate(setIndex);\n    }\n\n    return 'rotate(90) translate(' + xOffset + ', -' + yOffset + ')';\n  }\n\n  getChromosomeSetYTranslate(setIndex) {\n    // Get additional padding caused by annotation tracks\n    var additionalPadding = this._getAdditionalOffset() * 0.3;\n    // If no detailed description provided just use one formula for all cases\n    return (\n      this.margin.left * (setIndex) + this._config.chrWidth +\n      additionalPadding * 2 + additionalPadding * setIndex\n    );\n  }\n\n  getChromosomeSetLabelXPosition(setIndex) {\n    return (\n      ((this._ploidy.getSetSize(setIndex) * this._config.chrWidth + 20) / -2) +\n      (this._config.ploidy > 1 ? 0 : this._config.chrWidth)\n    );\n  }\n\n  getChromosomeLabelXPosition() {\n    return this._config.chrWidth / -2;\n  }\n\n}\n\nexport default SmallLayout;\n","import {d3} from '../lib';\nimport {Ploidy} from '../ploidy';\nimport {getLayout} from '../layouts/layout-adapter';\n\n/**\n * If ploidy description is a string, then convert it to the canonical\n * array format.  String ploidyDesc is used when depicting e.g. parental\n * origin each member of chromosome pair in a human genome.\n * See ploidy-basic.html for usage example.\n */\nfunction setPloidy(ideo) {\n  if (\n    'ploidyDesc' in ideo.config &&\n    typeof ideo.config.ploidyDesc === 'string'\n  ) {\n    var tmp = [];\n    for (var i = 0; i < ideo.numChromosomes; i++) {\n      tmp.push(ideo.config.ploidyDesc);\n    }\n    ideo.config.ploidyDesc = tmp;\n  }\n  // Organism ploidy description\n  ideo._ploidy = new Ploidy(ideo.config);\n}\n\nfunction getContainerSvgClass(ideo) {\n  var svgClass = '';\n  if (ideo.config.showChromosomeLabels) {\n    if (ideo.config.orientation === 'horizontal') {\n      svgClass += 'labeledLeft ';\n    } else {\n      svgClass += 'labeled ';\n    }\n  }\n\n  if (ideo.config.rotatable === false) {\n    svgClass += 'no-rotate ';\n  }\n\n  if (\n    ideo.config.annotationsLayout &&\n    ideo.config.annotationsLayout === 'overlay'\n  ) {\n    svgClass += 'faint';\n  }\n\n  return svgClass;\n}\n\n/**\n * Write tooltip div setup with default styling.\n */\nfunction writeTooltipContainer(ideo) {\n  d3.select(ideo.config.container + ' #_ideogramOuterWrap').append('div')\n    .attr('class', '_ideogramTooltip')\n    .attr('id', '_ideogramTooltip')\n    .style('opacity', 0)\n    .style('position', 'fixed')\n    .style('text-align', 'center')\n    .style('padding', '4px')\n    .style('font', '12px sans-serif')\n    .style('background', 'white')\n    .style('border', '1px solid black')\n    .style('border-radius', '5px')\n    .style('z-index', '1000');\n}\n\nfunction writeContainerDom(ideo) {\n\n  // Remove any previous container content\n  d3.selectAll(ideo.config.container + ' #_ideogramOuterWrap').remove();\n\n  d3.select(ideo.config.container)\n    .append('div')\n    .attr('id', '_ideogramOuterWrap')\n    .append('div')\n    .attr('id', '_ideogramTrackLabelContainer')\n    .style('position', 'absolute');\n\n  d3.select(ideo.config.container + ' #_ideogramOuterWrap').append('div')\n    .attr('id', '_ideogramMiddleWrap') // needed for overflow and scrolling\n    .style('position', 'relative')\n    .style('overflow-x', 'auto')\n    .style('transform', 'translateZ(0)') // add compositing layer for ideogram\n    .append('div')\n    .attr('id', '_ideogramInnerWrap') // needed for overflow and scrolling\n    .append('svg')\n    .attr('id', '_ideogram')\n    .attr('class', getContainerSvgClass(ideo))\n    .attr('width', ideo._layout.getWidth())\n    .attr('height', ideo._layout.getHeight())\n    .html(ideo.getBandColorGradients());\n}\n\n/**\n * Writes the HTML elements that contain this ideogram instance.\n */\nfunction writeContainer(t0) {\n  var ideo = this;\n\n  if (ideo.config.annotationsPath) {\n    ideo.fetchAnnots(ideo.config.annotationsPath);\n  }\n\n  setPloidy(ideo);\n\n  ideo._layout = getLayout(ideo);\n\n  writeContainerDom(ideo);\n\n  ideo.isOnlyIdeogram = document.querySelectorAll('#_ideogram').length === 1;\n  writeTooltipContainer(ideo);\n  ideo.finishInit(t0);\n}\n\nexport {writeContainer};\n","import VerticalLayout from './vertical-layout';\nimport HorizontalLayout from './horizontal-layout';\nimport PairedLayout from './paired-layout';\nimport SmallLayout from './small-layout';\n\nfunction getLayout(ideo) {\n  var config = ideo.config;\n\n  if ('perspective' in config && config.perspective === 'comparative') {\n    return new PairedLayout(config, ideo);\n  } else if ('rows' in config && config.rows > 1) {\n    return new SmallLayout(config, ideo);\n  } else if (config.orientation === 'vertical') {\n    return new VerticalLayout(config, ideo);\n  } else if (config.orientation === 'horizontal') {\n    return new HorizontalLayout(config, ideo);\n  } else {\n    return new VerticalLayout(config, ideo);\n  }\n}\n\nexport {getLayout};\n","import {hasNonGenBankAssembly, fetchWithRetry} from '../lib';\n\nvar lastBandDataUrl = '';\n\nfunction getBandUrl(bandDataFileNames, taxid, ideo) {\n  return ideo.config.dataDir + bandDataFileNames[taxid];\n}\n\nfunction shouldFetchBands(bandDataFileNames, taxid, ideo) {\n  var bandDataUrl = getBandUrl(bandDataFileNames, taxid, ideo);\n  return (\n    !(typeof window.chrBands !== 'undefined' && lastBandDataUrl === '') ||\n    lastBandDataUrl !== bandDataUrl\n  ) &&\n  hasNonGenBankAssembly(ideo) &&\n  taxid in bandDataFileNames;\n}\n\nfunction setBandData(url, fileNames, chrBands, ideo) {\n  var taxid, fetchedTaxid, fileName;\n\n  // Ensures correct taxid is processed in response callback;\n  // using simply upstream 'taxid' variable gives the last\n  // *requested* taxid, which fails when dealing with multiple taxa.\n  for (taxid in fileNames) {\n    fileName = fileNames[taxid];\n    if (url.includes(fileName) && fileName !== '') {\n      fetchedTaxid = taxid;\n    }\n  }\n\n  ideo.bandData[fetchedTaxid] = chrBands;\n}\n\nfunction fetchBands(bandDataFileNames, taxid, t0, ideo) {\n  var bandDataUrl = getBandUrl(bandDataFileNames, taxid, ideo);\n\n  if (!ideo.numBandDataResponses) ideo.numBandDataResponses = 0;\n\n  return fetchWithRetry(bandDataUrl)\n    .then(function(response) {\n      return response.json().then(function(rawBands) {\n        lastBandDataUrl = bandDataUrl;\n\n        delete window.chrBands; // Remove any previous chrBands variable\n        window.chrBands = rawBands.chrBands;\n\n        setBandData(response.url, bandDataFileNames, chrBands, ideo);\n      });\n    });\n}\n\nexport {shouldFetchBands, fetchBands};\n","/**\n * @fileoveriew Methods for initialization\n */\n\nimport {d3, slug} from '../lib';\nimport {configure} from './configure';\nimport {finishInit} from './finish-init';\nimport {writeContainer} from './write-container';\nimport {shouldFetchBands, fetchBands} from '../bands/fetch';\nimport {organismMetadata} from './organism-metadata';\n\nfunction isHeterogameticChromosome(chrModel, chrIndex, ideo) {\n  var ploidy = ideo.config.ploidy;\n  return (\n    'sex' in ideo.config &&\n      (\n        ploidy === 2 && ideo.sexChromosomes.index + 1 === chrIndex ||\n        ideo.config.sex === 'female' && chrModel.name === 'Y'\n      )\n  );\n}\n\nfunction prepareChromosomes(bandsArray, chrs, taxid, ideo) {\n  var j, bands, chromosome, chrModel, chrIndex;\n\n  for (j = 0; j < chrs.length; j++) {\n    chromosome = chrs[j];\n    if (typeof bandsArray !== 'undefined') bands = bandsArray[j];\n\n    chrIndex = j + ideo.config.taxids.indexOf(taxid);\n    chrModel = ideo.getChromosomeModel(bands, chromosome, taxid, chrIndex);\n\n    if (typeof chromosome !== 'string') {\n      chromosome = chromosome.name.split(' ').slice(-1)[0].replace('chr', '');\n    }\n\n    ideo.chromosomes[taxid][chromosome] = chrModel;\n    ideo.chromosomesArray.push(chrModel);\n\n    if (isHeterogameticChromosome(chrModel, j, ideo)) continue;\n\n    ideo.drawChromosome(chrModel);\n  }\n}\n\nfunction setCoordinateSystem(chrs, ideo) {\n  if (\n    typeof chrBands !== 'undefined' &&\n    chrs.length >= chrBands.length / 2\n  ) {\n    ideo.coordinateSystem = 'bp';\n  }\n}\n\n/**\n * Configures chromosome data and calls downstream chromosome drawing functions\n */\nfunction initDrawChromosomes() {\n  var taxid, i, chrs, bandsArray,\n    ideo = this,\n    taxids = ideo.config.taxids;\n\n  for (i = 0; i < taxids.length; i++) {\n    taxid = taxids[i];\n    chrs = ideo.config.chromosomes[taxid];\n\n    bandsArray = ideo.bandsArray[taxid];\n\n    if (!ideo.config.showNonNuclearChromosomes) {\n      // Remove MT\n      // TODO: Handle other non-nuclear chromosomes, e.g. CP, AP\n      chrs = chrs.filter(chr => chr !== 'MT');\n      if (typeof bandsArray !== 'undefined') {\n        bandsArray = bandsArray.filter(bands => {\n          return bands[0].chr !== 'MT';\n        });\n      }\n    }\n\n    setCoordinateSystem(chrs, ideo);\n\n    ideo.chromosomes[taxid] = {};\n    ideo.setSexChromosomes(chrs);\n\n    prepareChromosomes(bandsArray, chrs, taxid, ideo);\n\n    if (ideo.config.showBandLabels) ideo.drawBandLabels(ideo.chromosomes);\n    ideo.handleRotateOnClick();\n    ideo._gotChrModels = true; // Prevent issue with errant rat centromeres\n  }\n}\n\n/**\n * Attach any click handlers to rotate and toggle chromosomes\n */\nfunction handleRotateOnClick() {\n  var ideo = this;\n\n  if (!('rotatable' in ideo.config && ideo.config.rotatable === false)) {\n    d3.selectAll(ideo.selector + ' .chromosome-set').on('click', function() {\n      // Handles click on chromosome graphic or label.\n      // Label click needed to toggle e.g. human MT\n      const element = this.children[1];\n\n      ideo.rotateAndToggleDisplay(element);\n    });\n  } else {\n    d3.selectAll(ideo.selector).style('cursor', 'default');\n  }\n}\n\n/**\n * Called when Ideogram has finished initializing.\n * Accounts for certain ideogram properties not being set until\n * asynchronous requests succeed, etc.\n */\nfunction onLoad() {\n  call(this.onLoadCallback);\n}\n\nfunction getBandFileName(taxid, accession, ideo) {\n  var organism = ideo.organisms[taxid];\n  var bandFileName = [slug(organism.scientificName)];\n  var assemblies = organism.assemblies;\n  var resolution = ideo.config.resolution;\n\n  if (accession !== assemblies.default) {\n    bandFileName.push(accession);\n  }\n  if (\n    taxid === '9606' &&\n    (accession in assemblies === 'false' &&\n      Object.values(assemblies).includes(config.assembly) ||\n      (resolution !== '' && resolution !== 850))\n  ) {\n    bandFileName.push(resolution);\n  }\n\n  bandFileName = bandFileName.join('-');\n\n  var fullyBandedTaxids = ['9606', '10090', '10116'];\n  if (fullyBandedTaxids.includes(taxid) && !ideo.config.showFullyBanded) {\n    bandFileName += '-no-bands';\n  }\n\n  bandFileName += '.json';\n\n  return bandFileName;\n}\n\nfunction getBandFileNames(taxid, bandFileNames, ideo) {\n  var organism, assemblies, accession, bandFileName,\n    config = ideo.config;\n\n  organism = ideo.organisms[taxid];\n\n  if (!config.assembly) ideo.config.assembly = 'default';\n\n  assemblies = organism.assemblies;\n\n  if (ideo.assemblyIsAccession()) {\n    accession = config.assembly;\n  } else {\n    accession = assemblies[config.assembly];\n  }\n\n  bandFileName = getBandFileName(taxid, accession, ideo);\n  var isCustomOrganism = taxid === '-1';\n\n  if (taxid in ideo.organismsWithBands || isCustomOrganism) {\n    bandFileNames[taxid] = bandFileName;\n  }\n  return bandFileNames;\n}\n\nfunction prepareContainer(taxid, bandFileNames, t0, ideo) {\n\n  if (shouldFetchBands(bandFileNames, taxid, ideo)) {\n    return fetchBands(bandFileNames, taxid, t0, ideo).then(function() {\n      return ideo.processBandData(taxid);\n    });\n  } else {\n    return new Promise(function(resolve) {\n      ideo.processBandData(taxid);\n      resolve([taxid, undefined]);\n    });\n  }\n}\n\nfunction initializeTaxids(ideo) {\n  return new Promise(function(resolve) {\n    var organism = ideo.config.organism;\n    if (typeof organism === 'number') {\n      // 'organism' is a taxid, e.g. 9606\n      ideo.getOrganismFromEutils(organism, function() {\n        ideo.getTaxids(resolve);\n      });\n    } else {\n      ideo.getTaxids(resolve);\n    }\n\n  });\n}\n\nfunction getBandsAndPrepareContainer(taxids, t0, ideo) {\n  var bandFileNames, i, taxid,\n    promises = [];\n\n  bandFileNames = {};\n  for (taxid in organismMetadata) {\n    bandFileNames[taxid] = '';\n  }\n\n  for (i = 0; i < taxids.length; i++) {\n    taxid = String(taxids[i]);\n    bandFileNames = getBandFileNames(taxid, bandFileNames, ideo);\n    promises.push(prepareContainer(taxid, bandFileNames, t0, ideo));\n  }\n\n  Promise.all(promises).then(function(taxidsAndBandsArrays) {\n    var taxidAndBandsArray, taxid, bandsArray;\n\n    for (i = 0; i < taxidsAndBandsArrays.length; i++) {\n      taxidAndBandsArray = taxidsAndBandsArrays[i];\n      taxid = taxidAndBandsArray[0];\n      bandsArray = taxidAndBandsArray[1];\n\n      if ('bandsArray' in ideo === false) {\n        ideo.bandsArray = {};\n      }\n\n      ideo.bandsArray[taxid] = bandsArray;\n    }\n    ideo.writeContainer(t0);\n  });\n}\n\n/**\n * Initializes an ideogram.\n * Sets some high-level properties based on instance configuration,\n * fetches band and annotation data if needed, and\n * writes an SVG element to the document to contain the ideogram\n */\n// Prevents race condition when init is called multiple times in\n// quick succession.\n// See https://github.com/eweitz/ideogram/pull/154.\nvar ideoNext = {};\nvar ideoQueued = {};\nvar ideoWait = {};\n\nfunction init(ideo) {\n  ideo = ideo || this;\n  var containerId = ideo.config.container;\n\n  if (ideoWait[containerId]) {\n    ideoQueued[containerId] = true;\n    ideoNext[containerId] = ideo;\n  } else {\n    ideoWait[containerId] = true;\n    initializeTaxids(ideo)\n      .then(function(taxids) {\n\n        var taxid = taxids[0];\n        ideo.config.taxid = taxid;\n        ideo.config.taxids = taxids;\n\n        ideo.organismScientificName =\n          ideo.getScientificName(ideo.config.taxid);\n\n        var t0 = new Date().getTime();\n        getBandsAndPrepareContainer(taxids, t0, ideo);\n\n        ideoWait[containerId] = false;\n        if (ideoQueued[containerId]) {\n          ideoQueued[containerId] = false;\n          init(ideoNext[containerId]);\n        }\n      });\n  }\n}\n\nexport {\n  configure, initDrawChromosomes, handleRotateOnClick,\n  onLoad, init, finishInit, writeContainer\n};\n","/**\n * @fileoverview Parse raw Ideogram.js annotations from a BED file\n * BED documentation: https://genome.ucsc.edu/FAQ/FAQformat#format1\n */\n\nexport class BedParser {\n\n  constructor(bed, ideo) {\n    this.rawAnnots = this.parseBed(bed, ideo);\n  }\n\n  // http://stackoverflow.com/a/5624139\n  static componentToHex(c) {\n    var hex = parseInt(c, 10).toString(16);\n    return hex.length === 1 ? '0' + hex : hex;\n  }\n\n  static rgbToHex(r, g, b) {\n    return (\n      '#' +\n      BedParser.componentToHex(r) +\n      BedParser.componentToHex(g) +\n      BedParser.componentToHex(b)\n    );\n  }\n\n  parseGenomicCoordinates(columns, ucscStyle) {\n    var chr, start, stop, length;\n\n    // These three columns (i.e. fields) are required\n    chr = columns[0];\n    start = parseInt(columns[1], 10);\n    stop = parseInt(columns[2], 10);\n\n    length = stop - start;\n\n    if (ucscStyle) {\n      chr = chr.slice(3);\n    }\n\n    return [chr, start, stop, length];\n  }\n\n  /**\n   * Parses an annotation from a tab-separated line of a BED file\n   */\n  parseAnnotFromTsvLine(tsvLine, chrs, ucscStyle) {\n    var annot, chrIndex, chr, start, rgb, color, label,\n      columns = tsvLine.split(/\\s/g);\n\n    [chr, start, stop, length] =\n      this.parseGenomicCoordinates(columns, ucscStyle);\n\n    chrIndex = chrs.indexOf(chr);\n    if (chrIndex === -1) return [null, null];\n\n    annot = ['', start, length, 0];\n\n    if (columns.length >= 4) {\n      label = columns[3];\n      annot[0] = label;\n    }\n\n    if (columns.length >= 8) {\n      rgb = columns[8].split(',');\n      color = BedParser.rgbToHex(rgb[0], rgb[1], rgb[2]);\n      annot.push(color);\n    }\n\n    return [chrIndex, annot];\n  }\n\n  parseRawAnnots(annots, bedStartIndex, tsvLines, chrs) {\n    var i, line, chrIndex, annot, keys, rawAnnots, ucscStyle;\n\n    ucscStyle = true;\n    if (isNaN(parseInt(tsvLines[bedStartIndex], 10)) === false) {\n      ucscStyle = false;\n    }\n\n    for (i = bedStartIndex; i < tsvLines.length; i++) {\n      line = tsvLines[i];\n      [chrIndex, annot] = this.parseAnnotFromTsvLine(line, chrs, ucscStyle);\n      if (chrIndex !== null) annots[chrIndex].annots.push(annot);\n    }\n\n    keys = ['name', 'start', 'length', 'trackIndex'];\n    if (tsvLines[bedStartIndex].length >= 8) keys.push('color');\n\n    rawAnnots = {keys: keys, annots: annots};\n\n    return rawAnnots;\n  }\n\n  /**\n  * Parses a BED file, returns raw annotations\n  */\n  parseBed(bed, ideo) {\n    var i, chrs, chr, bedStartIndex, rawAnnots,\n      annots = [],\n      tsvLines = bed.split(/\\r\\n|\\n/);\n\n    chrs = Object.keys(ideo.chromosomes[ideo.config.taxid]);\n\n    for (i = 0; i < chrs.length; i++) {\n      chr = chrs[i];\n      annots.push({chr: chr, annots: []});\n    }\n\n    bedStartIndex = 0; // 1 if BED has header (i.e. track line), 0 otherwise\n    if (tsvLines[0].slice(0, 3) === 'chr' || isNaN(parseInt(tsvLines[0], 10))) {\n      bedStartIndex = 1;\n    }\n\n    rawAnnots = this.parseRawAnnots(annots, bedStartIndex, tsvLines, chrs);\n    return rawAnnots;\n  }\n\n}\n","/**\n * @fileoverview Parse raw Ideogram.js annotations from a TSV file\n */\n\nimport {camel} from './../lib';\n\nexport class TsvParser {\n\n  constructor(tsv, ideo) {\n    this.rawAnnots = this.parseTsv(tsv, ideo);\n  }\n\n  parseGenomicCoordinates(columns) {\n    // These three columns (i.e. fields) are required\n    const chr = columns[1];\n    const start = parseInt(columns[2], 10);\n    const length = parseInt(columns[3], 10);\n\n    return [chr, start, length];\n  }\n\n  /**\n  * Parses a TSV file, returns raw annotations\n  */\n  parseTsv(tsv, ideo) {\n    const lines = tsv.split(/\\r\\n|\\n/);\n\n    const chrs = Object.keys(ideo.chromosomes[ideo.config.taxid]);\n\n    const annots = [];\n\n    for (let i = 0; i < chrs.length; i++) {\n      const chr = chrs[i];\n      annots.push({chr, annots: []});\n    }\n\n    let headers;\n    const innerKeysByField = {};\n    const customHeaders = [];\n\n    const numRequired = 4;\n    // let numColumns;\n\n    for (let i = 0; i < lines.length; i++) {\n      const line = lines[i];\n      if (line === '') continue; // Skip empty lines\n\n      // Parse headers\n      if (line[0] === '#') {\n        if (line[1] === '#') {\n          // Parse inner field keys in metainformation lines\n          // E.g. ## differential_expression keys: gene;log2fc;pval_adj\n          const keySplit = line.split(' keys: ');\n          if (keySplit.length > 1) {\n            const field = keySplit[0].slice(3);\n            const keys = keySplit[1].split(';');\n            innerKeysByField[camel(field)] = keys;\n          }\n        } else {\n          // Slice/trim off \"# \", take columns 5 and onward, e.g.:\n          // full_name\\tmentions\\tdifferential_expression\\tinterest_rank\n          headers = line.slice(1).trim().split(/\\t/).map(h => camel(h));\n          // numColumns = headers.length;\n          const customs = headers.slice(numRequired);\n          customs.forEach((custom, i) => customHeaders.push(camel(custom)));\n        }\n        continue;\n      }\n\n      const columns = line.trim().split(/\\t/);\n      const name = columns[0];\n\n      const [chr, start, length] = this.parseGenomicCoordinates(columns);\n      const chrIndex = chrs.indexOf(chr);\n      if (chrIndex === -1) continue;\n\n      const customValues = columns.slice(numRequired);\n      for (let j = 0; j < numRequired; j++) {\n        const customHeader = customHeaders[j];\n        if (customHeader in innerKeysByField) {\n          const innerKeys = innerKeysByField[customHeader]\n          const block = columns[numRequired + j];\n          const group = block.split(';');\n          const customValue = [];\n          if (group[0] !== '') {\n            for (let k = 0; k < group.length; k++) {\n              const innerObj = {};\n              const innerValues = group[k].split('!');\n              for (let m = 0; m < innerValues.length; m++) {\n                const innerKey = innerKeys[m];\n                const innerValue = innerValues[m];\n                innerObj[camel(innerKey)] = innerValue;\n              }\n              customValue.push(innerObj);\n            }\n          }\n          customValues[j] = customValue;\n        }\n      }\n\n\n      const annot = [name, chr, start, length].concat(customValues);\n\n      annots[chrIndex].annots.push(annot);\n    };\n\n    const rawAnnots = {keys: headers, annots, innerKeysByField};\n    return rawAnnots;\n  }\n}\n","/**\n * @fileoverview Functions used by parallel and collinear heatmaps.\n */\n\nvar reservedTrackKeys = [\n  'name', 'start', 'length', 'trackIndex', 'trackIndexOriginal', 'color'\n];\n\nvar defaultHeatmapColors = {\n  3: ['00B', 'DDD', 'F00'],\n  5: ['00D', '66D', 'DDD', 'F88', 'F00'],\n  17: [\n    '00D', '00D', '00D', '00D', '00D', '44D', '44D', 'DDD', 'DDD',\n    'DDD', 'DDD', 'F88', 'F66', 'F22', 'F22', 'F00', 'F00', 'F00'\n  ]\n};\n\n/**\n * Get label text for displayed tracks from annotation container metadata,\n * heatmap keys, or annotation container keys\n */\nfunction getLabels(ideo) {\n  var annotKeys, labels, heatmaps, i;\n\n  if (ideo.rawAnnots.metadata && ideo.rawAnnots.metadata.trackLabels) {\n    labels = ideo.rawAnnots.metadata.trackLabels;\n  } else if (ideo.config.heatmaps) {\n    labels = [];\n    heatmaps = ideo.config.heatmaps;\n    for (i = 0; i < heatmaps.length; i++) {\n      labels.push(heatmaps[i].key);\n    }\n  } else {\n    annotKeys = ideo.rawAnnots.keys.slice(0);\n    labels = annotKeys.filter(d => !reservedTrackKeys.includes(d));\n  }\n\n  if (ideo.displayedTrackIndexes) {\n    labels = labels.filter(function(d, i) {\n      return ideo.displayedTrackIndexes.includes(i + 1);\n    });\n  }\n\n  return labels;\n}\n\n/**\n * Apply heatmap thresholds that are passed in as annotation metadata\n */\nfunction inflateThresholds(ideo) {\n  var thresholds, colors,\n    rawAnnots = ideo.rawAnnots;\n\n  if (\n    rawAnnots.metadata && !rawAnnots.metadata.heatmapThresholds &&\n    !ideo.config.heatmapThresholds\n  ) {\n    return;\n  }\n\n  if (ideo.config.heatmapThresholds) {\n    thresholds = ideo.config.heatmapThresholds;\n  } else {\n    thresholds = ideo.rawAnnots.metadata.heatmapThresholds;\n  }\n\n  colors = defaultHeatmapColors[thresholds.length + 1];\n  thresholds = thresholds.map((d, i) => {\n    return [d, '#' + colors[i]];\n  });\n\n  thresholds.push(['+', '#' + colors.slice(-1)[0]]);\n\n  return thresholds;\n}\n\n/**\n * Set needed configuration options from raw annotation data.\n * Simplifies heatmap API by inferring reasonable defaults.\n */\nfunction inflateHeatmaps(ideo) {\n  var i, labels, heatmaps, annotationTracks, rawAnnots, displayedTracks,\n    thresholds = ideo.config.heatmapThresholds;\n\n  heatmaps = [];\n  rawAnnots = ideo.rawAnnots;\n  labels = rawAnnots.keys.slice(3);\n\n  annotationTracks = [];\n  displayedTracks = [];\n  if (rawAnnots.metadata || !isNaN(thresholds[0])) {\n    thresholds = inflateThresholds(ideo);\n  }\n\n  for (i = 0; i < labels.length; i++) {\n    heatmaps.push({key: labels[i], thresholds: thresholds});\n    annotationTracks.push({id: labels[i]});\n    displayedTracks.push(i + 1);\n  }\n  ideo.config.annotationsNumTracks = labels.length;\n  ideo.config.annotationsDisplayedTracks = displayedTracks;\n  ideo.config.heatmaps = heatmaps;\n  ideo.config.annotationTracks = annotationTracks;\n}\n\n/**\n * Given annotation value (m), should it use the color in this threshold?\n */\nfunction shouldUseThresholdColor(m, numThresholds, value, prevThreshold,\n  threshold) {\n\n  return (\n    // If this is the last threshold, and\n    // its value is \"+\" and the value is above the previous threshold...\n    m === numThresholds && (\n      threshold === '+' && value > prevThreshold\n    ) ||\n\n    // ... or if the value matches the threshold...\n    value === threshold ||\n\n    // ... or if this isn't the first or last threshold, and\n    // the value is between this threshold and the previous one...\n    m !== 0 && m !== numThresholds && (\n      value <= threshold &&\n      value > prevThreshold\n    ) ||\n\n    // ... or if this is the first threshold and the value is\n    // at or below the threshold\n    m === 0 && value <= threshold\n  );\n}\n\n/**\n * Determine the color of the heatmap annotation.\n */\nfunction getHeatmapAnnotColor(thresholds, value) {\n  var m, numThresholds, thresholdList, threshold, tvNum, thresholdColor,\n    prevThreshold, useThresholdColor, color;\n\n  for (m = 0; m < thresholds.length; m++) {\n    numThresholds = thresholds.length - 1;\n    thresholdList = thresholds[m];\n    threshold = thresholdList[0];\n\n    // The threshold value is usually a number,\n    // but can also be a \"+\" character indicating that\n    // this threshold is anything greater than the previous threshold.\n    tvNum = parseFloat(threshold);\n    if (isNaN(tvNum) === false) threshold = tvNum;\n    if (m !== 0) prevThreshold = parseFloat(thresholds[m - 1][0]);\n    thresholdColor = thresholdList[1];\n\n    useThresholdColor = shouldUseThresholdColor(m, numThresholds, value,\n      prevThreshold, threshold);\n\n    if (useThresholdColor) color = thresholdColor;\n  }\n\n  return color;\n}\n\nexport {\n  getLabels, inflateHeatmaps, inflateThresholds, defaultHeatmapColors,\n  getHeatmapAnnotColor\n};\n","/**\n * @fileoverview Functions for collinear heatmaps of genome annotations.\n * See heatmap.js for more.\n */\n\nimport {d3} from '../lib';\nimport {writeTrackLabels} from './track-labels-collinear';\nimport {inflateHeatmaps} from './heatmap-lib';\n\n/**\n * Add canvases that will contain annotations.  One canvas per track.\n */\nfunction writeCanvases(chr, chrLeft, ideo) {\n  var j, trackLeft, trackWidth, canvas, context, id,\n    chrWidth = chr.width,\n    contextArray = [],\n    annotLabelHeight = ideo.config.annotLabelHeight,\n    numAnnotTracks = ideo.config.numAnnotTracks;\n\n  // Create a canvas for each annotation track on this chromosome\n  for (j = 0; j < numAnnotTracks; j++) {\n    trackWidth = ideo.config.annotationHeight + annotLabelHeight + 4;\n    id = chr.id + '-canvas-' + j; // e.g. chr1-9606-canvas-0\n    trackLeft = chrLeft;\n    if (chr.chrIndex > 0) {\n      trackLeft += (ideo.config.chrMargin * chr.chrIndex) - 1;\n    }\n    canvas = d3.select(ideo.config.container + ' #_ideogramInnerWrap')\n      .append('canvas')\n      .attr('id', id)\n      .attr('width', chrWidth + 1)\n      .attr('height', trackWidth)\n      .style('position', 'absolute')\n      .style('left', trackLeft + 'px')\n      .style('top', (trackWidth * j + 1) + 'px');\n    context = canvas.nodes()[0].getContext('2d');\n    contextArray.push([context, chr]);\n  }\n\n  return contextArray;\n}\n\n/**\n * Render annotations on the canvas\n */\nfunction fillCanvasAnnots(annots, contextArray, ideo) {\n  var j, annot, context, chr,\n    annotLabelHeight = ideo.config.annotLabelHeight,\n    annotHeight = ideo.config.annotationHeight,\n    demarcateChrs = ideo.config.demarcateCollinearChromosomes;\n\n  var trackWidth = annotHeight + annotLabelHeight + 4;\n\n  // Fill in the canvas(es) with annotation colors to draw a heatmap\n  for (j = 0; j < annots.length; j++) {\n    annot = annots[j];\n    context = contextArray[annot.trackIndex][0];\n    chr = contextArray[annot.trackIndex][1];\n    context.fillStyle = annot.color;\n    if (demarcateChrs) {\n      if (annot.startPx < 1 || annot.startPx > chr.width - 1) continue;\n      context.fillRect(annot.startPx, 1, 0.5, trackWidth);\n    } else {\n      context.fillRect(annot.startPx, annotLabelHeight + 1, 0.5, annotHeight);\n    }\n  }\n\n  if (demarcateChrs) {\n    for (j = 0; j < contextArray.length; j++) {\n      context = contextArray[j][0];\n      chr = contextArray[j][1];\n      context.fillStyle = '#555';\n      if (chr.chrIndex === 0) context.fillRect(0, 0, 1, trackWidth);\n      context.fillRect(chr.width - 1, 0, 1.1, trackWidth);\n      context.fillRect(0, 0, chr.width + 1, 1);\n      if (ideo.config.chrMargin) context.fillRect(0, 0, 1.1, trackWidth);\n    }\n  }\n}\n\n/**\n * Draw a 1D heatmap of annotations along each chromosome.\n * Ideal for representing very dense annotation sets in a granular manner\n * without subsampling.\n *\n * TODO:\n * - Support in 'vertical' orientation\n * - Support after rotating chromosome on click\n */\nfunction drawHeatmapsCollinear(annotContainers, ideo) {\n  var annots, chrLeft, contextArray, i, chr,\n    prevX = 0,\n    xBump = (ideo.config.showChromosomesLabels) ? 2 : -0.1;\n\n  d3.select(ideo.selector).classed('labeledLeft', false);\n  d3.selectAll(ideo.config.container + ' canvas').remove();\n\n  // Each \"annotationContainer\" represents annotations for a chromosome\n  for (i = 0; i < annotContainers.length; i++) {\n    annots = annotContainers[i].annots;\n    chr = ideo.chromosomesArray[i];\n    if (i === 0) {\n      chrLeft = 12;\n    } else {\n      chrLeft = prevX + ideo.chromosomesArray[i - 1].width + 14;\n      prevX += ideo.chromosomesArray[i - 1].width + xBump;\n    }\n    contextArray = writeCanvases(chr, chrLeft, ideo);\n    fillCanvasAnnots(annots, contextArray, ideo);\n  }\n\n  writeTrackLabels(ideo);\n\n  if (ideo.onDrawAnnotsCallback) ideo.onDrawAnnotsCallback();\n}\n\nexport {drawHeatmapsCollinear, inflateHeatmaps};\n","/**\n * @fileoverview Functions for 2D heatmaps of genome annotations.\n * 2D heatmaps enable showing many (100+) tracks of data in one dimension,\n * for features (e.g. genes) along a dimension of genomic coordinates in\n * chromosome context.\n *\n * TO DO:\n * - Horizontal orientation\n * - Multiple chromosomes\n * - Non-human organisms\n */\n\nimport {d3} from '../lib';\nimport {getHeatmapAnnotColor} from './heatmap-lib';\n\n/**\n * Add one canvas that will contain all annotations.  One canvas per chromosome.\n */\nfunction writeCanvas(chr, ideoHeight, width, ideo) {\n  var left, canvas, context, id;\n\n  id = chr.id + '-canvas'; // e.g. chr1-9606-canvas\n  left = (ideo.config.chrWidth * 2) + ideo.config.annotationHeight - 0.5;\n  canvas = d3.select(ideo.config.container + ' #_ideogramInnerWrap')\n    .append('canvas')\n    .attr('id', id)\n    .attr('width', width)\n    .attr('height', ideoHeight)\n    .style('position', 'absolute')\n    .style('left', left + 'px')\n    .style('top', '0px');\n  context = canvas.nodes()[0].getContext('2d');\n\n  return context;\n}\n\n/**\n * Render annotations on the canvas.\n *\n * These annotations are 2D; each annotation has many values, each on a track.\n */\nfunction fillCanvasAnnotValues(annot, context, ideo) {\n  var i, x, values,\n    annotHeight = ideo.config.annotationHeight,\n    ideoMarginTop = ideo._layout.margin.top;\n\n  values = annot.values;\n\n  // Fill canvas with annotation colors to draw the heatmap\n  for (i = 0; i < values.length; i++) {\n    context.fillStyle = values[i];\n    x = (i - 1) * annotHeight;\n    context.fillRect(x, annot.startPx + ideoMarginTop, annotHeight, 2);\n  }\n}\n\n/**\n * Draw a 2D heatmap of annotations along one chromosome.\n *\n * TODO:\n * - Support in 'horizontal' orientation\n * - Support after rotating chromosome on click\n */\nfunction drawHeatmaps2d(annotContainers, ideo) {\n  var annot, context, i, chr,\n    container = ideo.config.container,\n    ideoMarginTop = ideo._layout.margin.top,\n    ideoHeight = ideo.config.chrHeight + ideoMarginTop,\n    width = ideo.config.annotationHeight * annotContainers[0].values.length;\n\n  d3.selectAll(container + ' canvas').remove();\n\n  d3.select(container + ' #_ideogramInnerWrap')\n    .style('max-width', width + 'px');\n  d3.select(container + ' #_ideogram').attr('width', width);\n\n  chr = ideo.chromosomesArray[0];\n\n  context = writeCanvas(chr, ideoHeight, width, ideo);\n\n  // Each \"annotationContainer\" represents annotations for a chromosome\n  for (i = 0; i < annotContainers.length; i++) {\n    annot = annotContainers[i];\n    fillCanvasAnnotValues(annot, context, ideo);\n  }\n\n  if (ideo.onDrawAnnotsCallback) {\n    ideo.onDrawAnnotsCallback();\n  }\n}\n\nfunction add2dAnnotsForChr(annots, omittedAnnots, annotsByChr, chrModel,\n  m, keys, ideo) {\n  var j, k, annot, ra, stop, stopPx, color,\n    thresholds = ideo.config.heatmapThresholds;\n\n  for (j = 0; j < annotsByChr.annots.length; j++) {\n    ra = annotsByChr.annots[j];\n    annot = {};\n\n    annot.values = []; // one value per track\n\n    for (k = 0; k < 3; k++) {\n      annot[keys[k]] = ra[k];\n    }\n\n    for (k = 3; k < keys.length; k++) {\n      color = getHeatmapAnnotColor(thresholds, ra[k]);\n      annot.values.push(color);\n    }\n\n    stop = annot.start + annot.length;\n\n    annot.chr = annotsByChr.chr;\n    annot.chrIndex = m;\n    annot.startPx = ideo.convertBpToPx(chrModel, annot.start);\n    stopPx = ideo.convertBpToPx(chrModel, stop);\n    annot.px = Math.round((annot.startPx + stopPx) / 2);\n\n    annots.push(annot);\n  }\n\n  annots.shift();\n\n  return [annots, omittedAnnots];\n}\n\nexport {drawHeatmaps2d, add2dAnnotsForChr};\n","/**\n * @fileoverview Functions for labeling tracks of genome annotations.\n * Tracks are columns of annotations that run beside a chromosome.\n * Labeling tracks with descriptive names makes them easier to understand.\n */\n\nimport {d3} from '../lib';\nimport {getLabels} from './heatmap-lib';\n\n/**\n * Start a timer that, upon expiring, hides the track label.\n *\n * To enable users to copy label content to their clipboard, a timer is\n * used to control when the label disappears.  It starts when the user's\n * cursor leaves the track or the label.  If the user moves the cursor\n * back over the annot or label after the timer starts and before it expires,\n * then the timer is cleared.\n */\nfunction startHideTrackLabelTimeout(ideo) {\n  if (ideo.config.showTrackLabel === false) return;\n\n  ideo.hideTrackLabelTimeout = window.setTimeout(function() {\n    d3.select(ideo.config.container + ' #_ideogramTrackLabel').transition()\n      .duration(500)\n      .style('opacity', 0);\n  }, 250);\n}\n\n/**\n * Write label div setup with default styling.\n */\nfunction writeTrackLabelContainer(ideo) {\n  d3.select(ideo.config.container + ' #_ideogramTrackLabelContainer')\n    .append('div')\n    .attr('id', '_ideogramTrackLabel')\n    .style('opacity', 0)\n    .style('position', 'absolute')\n    .style('text-align', 'center')\n    .style('padding', '1px')\n    .style('font', '11px sans-serif')\n    .style('background', 'white')\n    .style('line-height', '10px')\n    .style('z-index', '9000');\n}\n\n/**\n * Display track labels on the page\n */\nfunction renderTrackLabels(top, left, ideo) {\n  d3.select(ideo.config.container + ' #_ideogramTrackLabel')\n    .style('opacity', 1) // Make label visible\n    .style('left', left + 'px')\n    .style('top', top + 'px')\n    .style('width', 'max-content')\n    .style('transform-origin', 'bottom left')\n    .style('text-align', 'left')\n    .on('mouseover', function() {\n      clearTimeout(ideo.hideTrackLabelTimeout);\n    })\n    .on('mouseout', function() {\n      startHideTrackLabelTimeout(ideo);\n    });\n}\n\n/**\n * Get left and top (x and y) offset for track label text\n */\nfunction getTrackLabelOffsets(labels, trackCanvas, ideo) {\n  var firstTrackId, firstTrack, trackBox, labelBox, ideoBox, left, top,\n    marginHack = 7; // TODO: Make this dynamic\n\n  firstTrackId = trackCanvas.id.split('-').slice(0, -1).join('-') + '-0';\n  firstTrack = d3.select(ideo.config.container + ' #' + firstTrackId)\n    .nodes()[0];\n  trackBox = firstTrack.getBoundingClientRect();\n\n  labelBox = d3.select(ideo.config.container + ' #_ideogramTrackLabel')\n    .nodes()[0].getBoundingClientRect();\n  ideoBox = d3.select(ideo.config.container).nodes()[0]\n    .getBoundingClientRect();\n\n  left = Math.round(trackBox.left + labelBox.width) - trackBox.width - 1;\n  left -= ideoBox.left - marginHack;\n  top = -(labels.split('<br>').length - 2) * trackBox.width + 2;\n\n  return [left, top];\n}\n\n/**\n * Show the label for this track\n */\nfunction showTrackLabel(trackCanvas, ideo) {\n  var labels, left, top;\n\n  clearTimeout(ideo.hideTrackLabelTimeout);\n\n  labels = getLabels(ideo);\n  labels = labels.join('<br>');\n\n  // Clear any previous positioning, write track label text to DOM\n  d3.select(ideo.config.container + ' #_ideogramTrackLabel')\n    .interrupt() // Stop any in-progress disapperance\n    .style('top', '')\n    .style('left', '')\n    .style('transform', null)\n    .style('transform', 'rotate(-90deg)')\n    .html(labels);\n\n  [left, top] = getTrackLabelOffsets(labels, trackCanvas, ideo);\n\n  renderTrackLabels(top, left, ideo);\n}\n\nexport {\n  startHideTrackLabelTimeout, writeTrackLabelContainer, showTrackLabel\n};\n","/**\n * @fileoverview Functions for 2D heatmaps of genome annotations.\n * Heatmaps provide an easy way to visualize very dense annotation data.\n * Unlike the rest of Ideogram's graphics, which use SVG, heatmaps are\n * rendered using the Canvas element.\n */\n\nimport {d3} from '../lib';\nimport {drawHeatmapsCollinear} from './heatmap-collinear';\nimport {drawHeatmaps2d} from './heatmap-2d';\nimport {getHeatmapAnnotColor} from './heatmap-lib';\n\nimport {\n  startHideTrackLabelTimeout, writeTrackLabelContainer, showTrackLabel\n} from './track-labels';\n\n/**\n * Add canvases that will contain annotations.  One canvas per track.\n */\nfunction writeCanvases(chr, chrLeft, ideoHeight, ideo) {\n  var j, trackLeft, trackWidth, canvas, context, id,\n    contextArray = [],\n    numAnnotTracks = ideo.config.numAnnotTracks;\n\n  var marginHack = 7; // TODO: Make this dynamic\n\n  // Create a canvas for each annotation track on this chromosome\n  for (j = 0; j < numAnnotTracks; j++) {\n    trackWidth = ideo.config.annotationHeight;\n    id = chr.id + '-canvas-' + j; // e.g. chr1-9606-canvas-0\n    trackLeft = chrLeft - trackWidth * (numAnnotTracks - j) - marginHack;\n    canvas = d3.select(ideo.config.container + ' #_ideogramInnerWrap')\n      .append('canvas')\n      .attr('id', id)\n      .attr('width', trackWidth)\n      .attr('height', ideoHeight)\n      .style('position', 'absolute')\n      .style('left', trackLeft + 'px');\n    context = canvas.nodes()[0].getContext('2d');\n    contextArray.push(context);\n  }\n\n  return contextArray;\n}\n\n/**\n * Render annotations on the canvas\n */\nfunction fillCanvasAnnots(annots, contextArray, chrWidth, ideoMarginTop) {\n  var j, annot, context, x;\n\n  // Fill in the canvas(es) with annotation colors to draw a heatmap\n  for (j = 0; j < annots.length; j++) {\n    annot = annots[j];\n    context = contextArray[annot.trackIndex];\n    context.fillStyle = annot.color;\n    x = annot.trackIndex - 1;\n    context.fillRect(x, annot.startPx + ideoMarginTop, chrWidth, 0.5);\n  }\n}\n\n/**\n * Draw a 1D heatmap of annotations along each chromosome.\n * Ideal for representing very dense annotation sets in a granular manner\n * without subsampling.\n *\n * TODO:\n * - Support in 'horizontal' orientation\n * - Support after rotating chromosome on click\n */\nfunction drawHeatmaps(annotContainers) {\n  var annots, chrLeft, contextArray, chrWidth, i, chr,\n    ideo = this,\n    config = ideo.config,\n    ideoMarginTop = ideo._layout.margin.top,\n    ideoHeight = config.chrHeight + ideoMarginTop;\n\n  if (config.geometry === 'collinear') {\n    return drawHeatmapsCollinear(annotContainers, ideo);\n  } else if (config.annotationsLayout === 'heatmap-2d') {\n    return drawHeatmaps2d(annotContainers, ideo);\n  }\n\n  d3.selectAll(ideo.config.container + ' canvas').remove();\n\n  writeTrackLabelContainer(ideo);\n\n  // Each \"annotationContainer\" represents annotations for a chromosome\n  for (i = 0; i < annotContainers.length; i++) {\n\n    annots = annotContainers[i].annots;\n    chr = ideo.chromosomesArray[i];\n    chrWidth = ideo.config.chrWidth;\n    chrLeft = ideo._layout.getChromosomeSetYTranslate(i);\n\n    contextArray = writeCanvases(chr, chrLeft, ideoHeight, ideo);\n    fillCanvasAnnots(annots, contextArray, chrWidth, ideoMarginTop);\n  }\n\n  d3.selectAll(ideo.config.container + ' canvas')\n    .on('mouseover', function() {showTrackLabel(this, ideo);})\n    .on('mouseout', function() {startHideTrackLabelTimeout(ideo);});\n\n  if (ideo.onDrawAnnotsCallback) {\n    ideo.onDrawAnnotsCallback();\n  }\n}\n\n/**\n * Set color and track index for raw annotation objects.\n */\nfunction getNewRawAnnots(heatmapKeyIndexes, rawAnnots, ideo) {\n  var j, k, ra, newRa, value, thresholds, color, trackIndex,\n    newRas = [];\n\n  for (j = 0; j < rawAnnots.length; j++) {\n    ra = rawAnnots[j];\n    for (k = 0; k < heatmapKeyIndexes.length; k++) {\n      newRa = ra.slice(0, 3); // name, start, length\n\n      value = ra[heatmapKeyIndexes[k]];\n      thresholds = ideo.config.heatmaps[k].thresholds;\n      color = getHeatmapAnnotColor(thresholds, value);\n\n      trackIndex = k;\n      newRa.push(trackIndex, color, value);\n      newRas.push(newRa);\n    }\n  }\n\n  return newRas;\n}\n\nfunction getNewRawAnnotContainers(heatmapKeyIndexes, rawAnnotBoxes, ideo) {\n  var raContainer, chr, rawAnnots, newRas, i,\n    newRaContainers = [];\n\n  for (i = 0; i < rawAnnotBoxes.length; i++) {\n    raContainer = rawAnnotBoxes[i];\n    chr = raContainer.chr;\n\n    rawAnnots = raContainer.annots;\n    newRas = getNewRawAnnots(heatmapKeyIndexes, rawAnnots, ideo);\n\n    newRaContainers.push({chr: chr, annots: newRas});\n  }\n  return newRaContainers;\n}\n\nfunction reportPerformance(t0, ideo) {\n  var t1 = new Date().getTime();\n  if (ideo.config.debug) {\n    console.log('Time in deserializeAnnotsForHeatmap: ' + (t1 - t0) + ' ms');\n  }\n}\n\n/**\n * Deserialize compressed annotation data into a format suited for heatmaps.\n *\n * This enables the annotations to be downloaded from a server without the\n * requested annotations JSON needing to explicitly specify track index or\n * color.  The track index and color are inferred from the \"heatmaps\" Ideogram\n * configuration option defined before ideogram initialization.\n *\n * This saves time for the user.\n *\n * @param rawAnnotsContainer {Object} Raw annotations as passed from server\n */\nfunction deserializeAnnotsForHeatmap(rawAnnotsContainer) {\n  var newRaContainers, heatmapKey, heatmapKeyIndexes, i,\n    t0 = new Date().getTime(),\n    keys = rawAnnotsContainer.keys,\n    rawAnnotBoxes = rawAnnotsContainer.annots,\n    ideo = this;\n\n  heatmapKeyIndexes = [];\n  for (i = 0; i < ideo.config.heatmaps.length; i++) {\n    heatmapKey = ideo.config.heatmaps[i].key;\n    heatmapKeyIndexes.push(keys.indexOf(heatmapKey));\n  }\n\n  newRaContainers =\n    getNewRawAnnotContainers(heatmapKeyIndexes, rawAnnotBoxes, ideo);\n\n  keys.splice(3, 0, 'trackIndex');\n  keys.splice(4, 0, 'color');\n\n  ideo.rawAnnots.keys = keys;\n  ideo.rawAnnots.annots = newRaContainers;\n\n  reportPerformance(t0, ideo);\n}\n\nexport {drawHeatmaps, deserializeAnnotsForHeatmap};\n","/**\n * @fileoverview Functions for labeling collinear tracks of genome annotations.\n * See track-labels.js for more.\n */\n\nimport {d3} from '../lib';\nimport {getLabels} from './heatmap-lib';\n\nfunction renderTrackLabels(labels, ideo) {\n  var i, x, y, labelContainer, markBump,\n    annotLabelHeight = ideo.config.annotLabelHeight,\n    demarcateChrs = ideo.config.demarcateCollinearChromosomes;\n\n  x = 11; // Close to chrLeft in heatmap-collinear.js.  For tabs.\n  markBump = (demarcateChrs ? 2 : 0); // Make labels flush with demarcations\n\n  labelContainer =\n    d3.select(ideo.config.container + ' #_ideogramTrackLabelContainer');\n  labelContainer.html('');\n\n  y = ideo.config.annotationHeight + annotLabelHeight + 4;\n\n  for (i = 0; i < labels.length; i++) {\n    labelContainer\n      .style('position', 'absolute')\n      .append('div')\n      .attr('class', '_ideogramTrackLabel')\n      .style('opacity', 1)\n      .style('position', 'absolute')\n      .style('text-align', 'center')\n      .style('padding', '1px')\n      .style('font', '11px sans-serif')\n      .style('background', 'white')\n      .style('line-height', '10px')\n      .style('z-index', '5')\n      .style('left', (x + markBump) + 'px')\n      .style('top', (y * i + markBump) + 'px')\n      .style('width', 'max-content')\n      .style('transform-origin', 'bottom left')\n      .style('text-align', 'left')\n      .html(labels[i]);\n  }\n\n}\n\n/**\n * Show the label for this track\n */\nfunction writeTrackLabels(ideo) {\n  var labels = getLabels(ideo);\n  renderTrackLabels(labels, ideo);\n}\n\nexport {writeTrackLabels};\n","import {d3, formatSiPrefix} from '../lib';\n// import {getShapes} from './draw';\n\n/**\n * Optional callback, invoked when annotations are drawn\n */\nfunction onLoadAnnots() {\n  call(this.onLoadAnnotsCallback);\n}\n\n/**\n * Optional callback, invoked when annotations are drawn\n */\nfunction onDrawAnnots() {\n  call(this.onDrawAnnotsCallback);\n}\n\nfunction hideAnnotTooltip() {\n  d3.select('._ideogramTooltip').transition()\n    .duration(500) // fade out for half second\n    .style('opacity', 0)\n    .style('pointer-events', 'none');\n}\n\n/**\n * Starts a timer that, upon expiring, hides the annotation tooltip.\n *\n * To enable users to copy tooltip content to their clipboard, a timer is\n * used to control when the tooltip disappears.  It starts when the user's\n * cursor leaves the annotation or the tooltip.  If the user moves the cursor\n * back over the annot or tooltip after the timer starts and before it expires,\n * then the timer is cleared.\n */\nfunction startHideAnnotTooltipTimeout() {\n  const ideo = this;\n\n  if (ideo.config.showAnnotTooltip === false) {\n    return;\n  }\n\n  // See \"Without this...\" note in gene-structure.js\n  const hideMs = ideo.oneTimeDelayTooltipHideMs ?? 250;\n  delete ideo.oneTimeDelayTooltipHideMs;\n\n  // Hide tooltip after `hideMs` milliseconds\n  ideo.hideAnnotTooltipTimeout = window.setTimeout(function() {\n    hideAnnotTooltip();\n  }, hideMs);\n\n  // Enable clients to not show tooltip immediately after clicking gene,\n  // e.g. in related genes kit\n  ideo.isTooltipCooling = true;\n  ideo.hideAnnotTooltipCounter = window.setTimeout(function() {\n    ideo.isTooltipCooling = false;\n  }, 500);\n}\n\nfunction renderTooltip(tooltip, content, matrix, yOffset, ideo) {\n  tooltip.html(content)\n    .style('opacity', 1) // Make tooltip visible\n    .style('left', matrix.e + 'px')\n    .style('top', (matrix.f - yOffset) + 'px')\n    .style('font-family', ideo.config.fontFamily)\n    .style('pointer-events', null) // Prevent bug in clicking chromosome\n    .on('mouseover', function() {\n      clearTimeout(ideo.hideAnnotTooltipTimeout);\n    })\n    .on('mouseout', function() {\n      ideo.startHideAnnotTooltipTimeout();\n    });\n}\n\nfunction getCoarseBpLength(annot) {\n  const length = Math.abs(annot.stop - annot.start);\n  return formatSiPrefix(length) + 'bp';\n}\n\nfunction getContentAndYOffset(annot, includeLength=false) {\n  var content, yOffset, range, displayName;\n\n  range = 'chr' + annot.chr + ':' + annot.start.toLocaleString();\n  if (annot.displayCoordinates) {\n    range = annot.displayCoordinates;\n  } else if (annot.length > 0) {\n    // Only show range if stop differs from start\n    range += '-' + annot.stop.toLocaleString();\n    if (includeLength) range += ' (' + getCoarseBpLength(annot) + ')';\n  }\n  content = `<span class=\"_ideoTooltipFooter\">${range}</span>`;\n  yOffset = 24;\n\n  if (annot.name) {\n    displayName = annot.displayName ? annot.displayName : annot.name;\n    content = displayName + '<br/>' + content;\n    yOffset += 8;\n  }\n\n  return [content, yOffset];\n}\n\n/**\n * Optional callback, invoked before showing annotation tooltip\n */\nfunction onWillShowAnnotTooltip(annot) {\n  call(this.onWillShowAnnotTooltipCallback, annot);\n}\n\nfunction onDidShowAnnotTooltip() {\n  call(this.onDidShowAnnotTooltipCallback);\n}\n\n/**\n * Optional callback, invoked on clicking annotation\n */\nfunction onClickAnnot(annot) {\n  this.prevClickedAnnot = annot;\n  this.onClickAnnotCallback(annot);\n}\n\n// /** Get list of annotation objects by names, e.g. [\"BRCA1\", \"APOE\"] */\n// function getAnnotsByName(annotNames, ideo) {\n//   return annotNames.map(name => getAnnotByName(name, ideo));\n// }\n\n/**\n * Shows a tooltip for the given annotation.\n *\n * See notes in startHideAnnotTooltipTimeout about show/hide logic.\n *\n * @param annot {Object} Processed annotation object\n * @param context {Object} \"This\" of the caller -- an SVG path DOM object\n */\nfunction showAnnotTooltip(annot, context) {\n  var matrix, content, yOffset, tooltip,\n    cx = Number(context.getAttribute('cx')),\n    cy = Number(context.getAttribute('cy')),\n    ideo = this;\n\n  if (ideo.config.showAnnotTooltip === false) return;\n\n  clearTimeout(ideo.hideAnnotTooltipTimeout);\n\n  if (ideo.onWillShowAnnotTooltipCallback) {\n    annot = ideo.onWillShowAnnotTooltipCallback(annot);\n  }\n\n  // Enable onWillShowAnnotTooltipCallback to cancel showing tooltip\n  if (annot === null) {\n    hideAnnotTooltip();\n    return;\n  }\n\n  ideo.prevTooltipAnnotName = annot.name;\n\n  tooltip = d3.select('._ideogramTooltip');\n  tooltip.interrupt(); // Stop any in-progress disapperance\n\n  matrix = context.getScreenCTM().translate(cx, cy);\n\n  const includeLength = true;\n  [content, yOffset] = getContentAndYOffset(annot, includeLength);\n\n  renderTooltip(tooltip, content, matrix, yOffset, ideo);\n\n  if (ideo.onDidShowAnnotTooltipCallback) {\n    ideo.onDidShowAnnotTooltipCallback();\n  }\n}\n\nexport {\n  onLoadAnnots, onDrawAnnots, startHideAnnotTooltipTimeout,\n  onWillShowAnnotTooltip, showAnnotTooltip, onClickAnnot,\n  onDidShowAnnotTooltip\n};\n","import {d3, getFont, getTextSize, deepCopy} from '../lib';\n\nimport {sortAnnotsByRank} from './annotations';\n\nconst allLabelStyle = `\n  <style>\n    #_ideogram .annot path, ._ideogramLabel {\n      cursor: pointer;\n    }\n\n    #_ideogram .annot path {\n      stroke-width: 1px;\n      stroke: white;\n      stroke-linejoin: bevel;\n    }\n\n    #_ideogram ._ideogramLabel._ideoActive {\n      fill: #77F !important;\n      stroke: #F0F0FF !important;\n    }\n\n    #_ideogram .annot > ._ideoActive {\n      stroke: #D0D0DD !important;\n      stroke-width: 1.5px;\n    }\n\n    #_ideogram ._ideogramLabel {\n      stroke: white;\n      stroke-width: 5px;\n      stroke-linejoin: round;\n      paint-order: stroke fill;\n      text-align: center;\n    }\n  </style>\n  `;\n\n/** Return DOM ID of annotation object */\nfunction getAnnotDomLabelId(annot) {\n  return 'ideogramLabel_' + annot.domId;\n}\n\nfunction changeAnnotState(state, labelId, annotId) {\n  d3.selectAll('._ideoActive').classed('_ideoActive', false);\n  d3.select('#' + labelId).attr('class', '_ideogramLabel ' + state);\n  d3.select('#' + annotId + ' > path').attr('class', state);\n}\n\nfunction triggerAnnotEvent(event, ideo) {\n  let labelId, annotId;\n  const target = event.target;\n  const type = event.type;\n\n  const targetClasses = Array.from(target.classList);\n  if (targetClasses.includes('_ideogramLabel')) {\n    labelId = target.id;\n    annotId = target.id.split('ideogramLabel_')[1];\n    d3.select('#' + annotId + ' path').dispatch(type);\n  } else {\n    const annotElement = target.parentElement;\n    labelId = 'ideogramLabel_' + annotElement.id;\n    annotId = annotElement.id;\n  }\n\n  if (type === 'mouseout') {\n    ideo.time.prevTooltipOff = performance.now();\n    ideo.time.prevTooltipAnnotDomId = annotId;\n  }\n\n  // On mouseover, activate immediately\n  // Otherwise, wait a moment (250 ms), then deactivate.\n  // Delayed deactivation mitigates flicker when moving from\n  // annot label to annot triangle.\n  if (type === 'mouseover') {\n    clearTimeout(window._ideoActiveTimeout);\n    changeAnnotState('_ideoActive', labelId, annotId);\n  } else {\n    window._ideoActiveTimeout = window.setTimeout(function() {\n      changeAnnotState('', labelId, annotId);\n    }, 250);\n  }\n}\n\nfunction renderLabel(annot, style, ideo) {\n\n  if (!ideo.didSetLabelStyle) {\n    document.querySelector('#_ideogramInnerWrap')\n      .insertAdjacentHTML('afterbegin', allLabelStyle);\n    ideo.didSetLabelStyle = true;\n  }\n\n  const id = getAnnotDomLabelId(annot);\n\n  const font = getFont(ideo);\n\n  const fill = annot.color === 'pink' ? '#CF406B' : annot.color;\n\n  d3.select('#_ideogram').append('text')\n    .attr('id', id)\n    .attr('class', '_ideogramLabel')\n    .attr('x', style.left)\n    .attr('y', style.top)\n    .style('font', font)\n    .style('fill', fill)\n    .style('pointer-events', null) // Prevent bug in clicking chromosome\n    .html(annot.name);\n}\n\n/** Get annotation object by name, e.g. \"BRCA1\" */\nfunction getAnnotByName(annotName, ideo) {\n  var annot;\n  var found = false;\n  ideo.annots.forEach((annotsByChr) => {\n    if (found) return;\n    annotsByChr.annots.forEach((thisAnnot) => {\n      if (found) return;\n      if (thisAnnot.name === annotName) {\n        annot = thisAnnot;\n        found = true;\n      }\n    });\n  });\n\n  return annot;\n}\n\n/** Get label's top and left offsets relative to chromosome, and width */\nfunction getAnnotLabelLayout(annot, ideo) {\n  var annotDom, annotRect, ideoRect, width, height, top, bottom, left, right,\n    config = ideo.config;\n\n  annotDom = document.querySelector('#' + annot.domId);\n\n  // Handles cases when annotation is not yet in DOM\n  if (annotDom === null) return null;\n\n  annotRect = annotDom.getBoundingClientRect();\n\n  ideoRect =\n    document.querySelector('#_ideogram').getBoundingClientRect();\n\n  const textSize = getTextSize(annot.name, ideo);\n  width = textSize.width;\n\n  // `pad` is a heuristic that accounts for:\n  // 1px left pad, 1px right pad, 1px right border, 1px left border\n  // as set in renderLabel\n  const pad = (config.fontFamily) ? 9 : 7;\n  width += pad;\n\n  const labelSize = config.annotLabelSize ? config.annotLabelSize : 13;\n\n  // Accounts for 1px top border, 1px bottom border as set in renderLabel\n  height = labelSize;\n\n  top = annotRect.top - ideoRect.top + height - 1;\n  bottom = top + height;\n  left = annotRect.left - ideoRect.left - width;\n  right = left + width;\n  name = annot.name;\n\n  return {top, bottom, right, left, width, height, name};\n}\n\n/**\n * Label an annotation.\n *\n * @param annotName {String} Name of annotation, e.g. \"BRCA1\"\n * @param backgroundColor {String} Background color.  Default: white.\n * @param backgroundColor {String} Border color.  Default: black.\n */\nfunction addAnnotLabel(annotName, backgroundColor, borderColor) {\n  var annot,\n    ideo = this;\n\n  annot = getAnnotByName(annotName, ideo);\n\n  const layout = getAnnotLabelLayout(annot, ideo);\n  if (layout === null) return;\n\n  const style = Object.assign(layout, {backgroundColor, borderColor});\n\n  renderLabel(annot, style, ideo);\n}\n\nfunction getIsXOverlap(o, n, p) {\n  const oLeft = o.left - p;\n  const nLeft = n.left - p;\n  const oRight = o.right + p;\n  const nRight = n.right + p;\n  // A) oLeft < nLeft && oLeft < nRight && oRight < nRight && oRight > nLeft\n  // o     o\n  // o     o\n  // o     o\n  //\n  //    n      n\n  //    n      n\n  //    n      n\n  //\n  // B) oLeft > nLeft && oLeft < nRight && oRight > nRight && oRight > nLeft\n  //    o     o\n  //    o     o\n  //    o     o\n  //\n  // n     n\n  // n     n\n  // n     n\n  //\n  // C) oLeft < nLeft && oLeft < nRight && oRight > nRight && oRight > nLeft\n  // o         o\n  // o         o\n  // o         o\n  //\n  //    n   n\n  //    n   n\n  //\n  // D) oLeft > nLeft && oLeft < nRight && oRight > nLeft && oRight < nRight\n  //    o   o\n  //    o   o\n  //    o   o\n  //\n  // n         n\n  // n         n\n  // n         n\n  return (\n    (oLeft <= nLeft && oLeft <= nRight && oRight <= nRight && oRight >= nLeft) ||\n    (oLeft >= nLeft && oLeft <= nRight && oRight >= nRight && oRight >= nLeft) ||\n    (oLeft <= nLeft && oLeft <= nRight && oRight >= nRight && oRight >= nLeft) ||\n    (oLeft >= nLeft && oLeft <= nRight && oRight >= nLeft && oRight <= nRight)\n  )\n}\n\nfunction getIsYOverlap(o, n, p) {\n    const oTop = o.top - p;\n    const nTop = n.top - p;\n    const oBottom = o.bottom + p;\n    const nBottom = n.bottom + p;\n    // Top of old annot (o) is above bottom of new annot (n),\n    // and bottom of old annot is below top of new annot\n    //\n    //  A) yOverlap = true\n    //      o.top < n.top && o.top < n.bottom && o.bottom < n.bottom && o.bottom > n.top\n    //    ooooo\n    //            nnnnn\n    //\n    //    ooooo\n    //            nnnnn\n    //\n    //  A.2)\n    //\n    //    ppppp\n    //    ppppp\n    //    ooooo\n    //\n    //            ppppp\n    //    ooooo   ppppp\n    //    ppppp   nnnnn\n    //    ppppp\n    //\n    //            nnnnn\n    //            ppppp\n    //            ppppp\n    //\n    //  B) yOverlap = true\n    //     o.top > n.top && o.top < n.bottom && o.bottom > n.bottom && o.bottom > n.top\n    //            nnnnn\n    //    ooooo\n    //\n    //            nnnnn\n    //    ooooo\n    //\n    //   B.2)\n    //\n    //            ppppp\n    //    ppppp   ppppp\n    //    ppppp   nnnnn\n    //    ooooo\n    //\n    //            nnnnn\n    //    ooooo   ppppp\n    //    ppppp   ppppp\n    //    ppppp\n    //\n    //\n    //  C) yOverlap = false\n    //     old.top < new.top && old.bottom < new.top\n    //    ooooo\n    //\n    //\n    //    ooooo\n    //\n    //          nnnnn\n    //\n    //\n    //          nnnnn\n    //\n    //  D) yOverlap = false\n    //          nnnnn\n    //\n    //\n    //          nnnnn\n    //\n    //    ooooo\n    //\n    //\n    //    ooooo\n    // sl.top - p < layout.bottom && sl.bottom > layout.top - p ||\n    // layout.top - p < sl.bottom && layout.bottom > sl.bottom\n\n    // XY overlap\n    // A)\n    //\n    //  ooooooo\n    //  o     o\n    //  o    nonnnnn\n    //  ooooooo    n\n    //       n     n\n    //       nnnnnnn\n    //\n    //\n    //  B)\n    //       ooooooo\n    //       o     o\n    //  nnnnnnn    o\n    //  n    onooooo\n    //  n     n\n    //  nnnnnnn\n    //\n    //  C)\n    //\n    //  ooooooo   nnnnnnn\n    //  o     o   n     n\n    //  o     o   n     n\n    //  ooooooo   nnnnnnn\n    //\n    //  D)\n    //\n    //  ooooooo\n    //  o     o\n    //  o     o\n    //  ooooooo\n    //\n    //  nnnnnnn\n    //  n     n\n    //  n     n\n    //  nnnnnnn\n    return (\n      // false\n      (oTop <= nTop && oTop <= nBottom && oBottom <= nBottom && oBottom >= nTop) ||\n      (oTop >= nTop && oTop <= nBottom && oBottom >= nBottom && oBottom >= nTop)\n    );\n\n    // (sl.top - p < layout.bottom || sl.bottom > layout.top - p) &&\n    // (layout.top - p < sl.bottom || layout.bottom > sl.bottom)\n}\n\n/** Label as many annotations as possible, without overlap */\nfunction fillAnnotLabels(sortedAnnots=[]) {\n  const ideo = this;\n\n  sortedAnnots = deepCopy(sortedAnnots); // copy by value\n\n  // Remove any pre-existing annotation labels, to avoid duplicates\n  ideo.clearAnnotLabels();\n\n  let spacedAnnots = [];\n  const spacedLayouts = [];\n\n  // sortedAnnots = applyRankCutoff(sortedAnnots, 100, ideo);\n\n  // sortedAnnots = sortedAnnots.sort(ideo.annotSortFunction);\n\n  if (sortedAnnots.length === 0) {\n    sortedAnnots = ideo.flattenAnnots();\n  }\n\n  const strokeWidth = 0; // like padding\n\n  sortedAnnots.forEach((annot, i) => {\n    const layout = getAnnotLabelLayout(annot, ideo);\n\n    if (layout === null) {\n      console.debug(annot.name + ' has null layout');\n      return;\n    }\n\n    const hasOverlap =\n      spacedLayouts.length > 0 && spacedLayouts.some((sl, j) => {\n        const xOverlap = getIsXOverlap(sl, layout, strokeWidth);\n        const yOverlap = getIsYOverlap(sl, layout, strokeWidth);\n\n        // if (annot.name === 'AKT1' || annot.name === 'XRCC3') {\n        //   const spacedAnnot = spacedAnnots[j].name;\n        //   if (spacedAnnot === 'HIF1A' || spacedAnnot === 'RAD51') {\n        //   // if (xOverlap && yOverlap) {\n        //     // console.log('sl.top - strokeWidth', sl.top - strokeWidth)\n        //     // console.log('sl.top - strokeWidth < layout.bottom')\n        //     // console.log(sl.top - strokeWidth < layout.bottom)\n        //     // console.log('sl.bottom > layout.top - strokeWidth')\n        //     // console.log(sl.bottom > layout.top - strokeWidth)\n        //     // console.log('layout.top - strokeWidth < sl.bottom')\n        //     // console.log(layout.top - strokeWidth < sl.bottom)\n        //     // console.log('layout.bottom > sl.bottom')\n        //     // console.log(layout.bottom > sl.bottom)\n        //     console.log(\n        //       'xOverlap, yOverlap, spacedAnnot, sl, annot.name, layout'\n        //     );\n        //     console.log(\n        //       xOverlap, yOverlap, spacedAnnot, sl, annot.name, layout\n        //     );\n        //   }\n        // }\n\n        // if (xOverlap && yOverlap) {\n        //   console.log('overlap! annot');\n        //   console.log(annot.name, annot.chr, annot.color);\n        // }\n        return xOverlap && yOverlap;\n      });\n\n    if (hasOverlap) return;\n\n    spacedAnnots.push(annot);\n    spacedLayouts.push(layout);\n  });\n\n  let numLabels = 10;\n  const config = ideo.config;\n  if ('relatedGenesMode' in config && config.relatedGenesMode === 'hints') {\n    numLabels = 20;\n  }\n  // spacedAnnots = applyRankCutoff(spacedAnnots, numLabels, ideo);\n  spacedAnnots = spacedAnnots.sort(ideo.annotSortFunction).slice(0, numLabels)\n\n\n  // Ensure highest-ranked annots are ordered last in SVG,\n  // to ensure the are written before lower-ranked annots\n  // (which, due to SVG z-index being tied to layering)\n  spacedAnnots.reverse();\n\n  spacedAnnots.forEach((annot) => {\n    ideo.addAnnotLabel(annot.name);\n  });\n\n  d3.selectAll('._ideogramLabel, .annot')\n    .on('mouseover', (event) => triggerAnnotEvent(event))\n    .on('mouseout', (event) => triggerAnnotEvent(event, ideo))\n    .on('click', (event) => triggerAnnotEvent(event));\n}\n\nfunction removeAnnotLabel(annotName) {\n  const ideo = this;\n  const annot = getAnnotByName(annotName, ideo);\n  const id = getAnnotDomLabelId(annot);\n  document.querySelector('#' + id).remove();\n}\n\nfunction clearAnnotLabels() {\n  const labels = document.querySelectorAll('._ideogramLabel');\n  labels.forEach((label) => {label.remove();});\n}\n\nexport {\n  addAnnotLabel, clearAnnotLabels, fillAnnotLabels, getAnnotLabelLayout,\n  removeAnnotLabel\n};\n","/**\n * Get containers to group individual annotations into higher-level \"bar\"\n * annotations.\n */\nfunction getRawBars(chrModels, ideo) {\n  var chr, chrModel, lastBand, numBins, bar, h, i, px,\n    barWidth = ideo.config.barWidth,\n    bars = [];\n\n  for (h = 0; h < ideo.chromosomesArray.length; h++) {\n    chr = ideo.chromosomesArray[h].name;\n    chrModel = chrModels[chr];\n    lastBand = chrModel.bands[chrModel.bands.length - 1];\n    numBins = Math.round(lastBand.px.stop / barWidth); // chrPxStop / barWidth\n    bar = {chr: chr, annots: []};\n\n    for (i = 0; i < numBins; i++) {\n      px = i * barWidth - ideo.bump;\n      bar.annots.push({\n        bp: ideo.convertPxToBp(chrModel, px + ideo.bump),\n        px: px,\n        count: 0,\n        chrIndex: chrModel.chrIndex,\n        chrName: chr,\n        color: ideo.config.annotationsColor,\n        annots: []\n      });\n    }\n    bars.push(bar);\n  }\n  return bars;\n}\n\n/**\n * Assign how many, and which annotations each histogram bar contains\n */\nfunction assignAnnotsToBars(annots, bars, chrModels, ideo) {\n  var chrAnnots, chrModel, barAnnots, h, i, annot, px, j, barPx, nextBarPx,\n    barWidth = ideo.config.barWidth;\n\n  for (h = 0; h < annots.length; h++) {\n    chrAnnots = annots[h].annots;\n    chrModel = chrModels[annots[h].chr]; // get chr by name\n    barAnnots = bars[chrModel.chrIndex].annots;\n    for (i = 0; i < chrAnnots.length; i++) {\n      annot = chrAnnots[i];\n      px = annot.px - ideo.bump;\n      for (j = 0; j < barAnnots.length; j++) {\n        barPx = barAnnots[j].px;\n        nextBarPx = barPx + barWidth;\n        if (j === barAnnots.length - 1) nextBarPx += barWidth;\n        if (px >= barPx && px < nextBarPx) {\n          bars[chrModel.chrIndex].annots[j].count += 1;\n          bars[chrModel.chrIndex].annots[j].annots.push(annot);\n          break;\n        }\n      }\n    }\n  }\n  return bars;\n}\n\nfunction setIdeoMaxAnnotsPerBar(bars, isFirstGet, ideo) {\n  var maxAnnotsPerBarAllChrs, i, maxAnnotsPerBar, annots, chr, j, barCount;\n\n  if (isFirstGet || ideo.config.histogramScaling === 'relative') {\n    maxAnnotsPerBarAllChrs = 0;\n    for (i = 0; i < bars.length; i++) {\n      maxAnnotsPerBar = 0;\n      annots = bars[i].annots;\n      chr = bars[i].chr;\n      for (j = 0; j < annots.length; j++) {\n        barCount = annots[j].count;\n        if (barCount > maxAnnotsPerBar) maxAnnotsPerBar = barCount;\n        if (barCount > maxAnnotsPerBarAllChrs) {\n          maxAnnotsPerBarAllChrs = barCount;\n        }\n      }\n      ideo.maxAnnotsPerBar[chr] = maxAnnotsPerBar;\n    }\n    ideo.maxAnnotsPerBarAllChrs = maxAnnotsPerBarAllChrs;\n  }\n}\n\n/**\n * Set each bar's height to be proportional to the height of the bar with the\n * most annotations\n */\nfunction setProportionalBarHeight(bars, ideo) {\n  var i, annots, chr, j, barCount, barCountRatio, height,\n    ideoIsRotated = ideo._layout._isRotated;\n\n  for (i = 0; i < bars.length; i++) {\n    annots = bars[i].annots;\n    chr = bars[i].chr;\n    for (j = 0; j < annots.length; j++) {\n      barCount = annots[j].count;\n      if (ideo.config.histogramScaling === 'relative') {\n        barCountRatio = barCount / ideo.maxAnnotsPerBar[chr];\n      } else {\n        barCountRatio = barCount / ideo.maxAnnotsPerBarAllChrs;\n      }\n      if (ideoIsRotated === false) {\n        height = barCountRatio * ideo.config.chrMargin;\n      } else {\n        height = barCountRatio * ideo.config.chrHeightOriginal * 3;\n      }\n      if (isNaN(height)) {\n        height = 0;\n      }\n      bars[i].annots[j].height = height;\n    }\n  }\n  return bars;\n}\n\nfunction reportGetHistogramBarPerformance(t0, ideo) {\n  var t1 = new Date().getTime();\n  if (ideo.config.debug) {\n    console.log('Time spent in getHistogramBars: ' + (t1 - t0) + ' ms');\n  }\n}\n\nfunction setIdeoHistogramScaling(ideo) {\n  if ('histogramScaling' in ideo.config === false) {\n    ideo.config.histogramScaling = 'absolute';\n  }\n}\n\n/**\n * Returns and sets bars used for histogram\n */\nfunction getHistogramBars(annots) {\n  var chrModels, bars,\n    isFirstGet = false,\n    t0 = new Date().getTime(),\n    ideo = this;\n\n  chrModels = ideo.chromosomes[ideo.config.taxid];\n\n  setIdeoHistogramScaling(ideo);\n\n  if (typeof ideo.maxAnnotsPerBar === 'undefined') {\n    ideo.maxAnnotsPerBar = {};\n    isFirstGet = true;\n  }\n\n  bars = getRawBars(chrModels, ideo);\n  bars = assignAnnotsToBars(annots, bars, chrModels, ideo);\n\n  setIdeoMaxAnnotsPerBar(bars, isFirstGet, ideo);\n  bars = setProportionalBarHeight(bars, ideo);\n\n  reportGetHistogramBarPerformance(t0, ideo);\n  ideo.bars = bars;\n  return bars;\n}\n\nfunction getHistogramPoints(d, chrWidth, chrWidths, ideo) {\n  var x1, x2, y1, y2;\n\n  x1 = d.px + ideo.bump;\n  x2 = d.px + ideo.config.barWidth + ideo.bump;\n  y1 = chrWidth;\n  y2 = chrWidth + d.height;\n\n  var thisChrWidth = chrWidths[d.chr];\n\n  if (x2 > thisChrWidth) {\n    x2 = thisChrWidth;\n  }\n\n  return (\n    x1 + ',' + y1 + ' ' +\n    x2 + ',' + y1 + ' ' +\n    x2 + ',' + y2 + ' ' +\n    x1 + ',' + y2\n  );\n}\n\nfunction writeHistogramAnnots(chrAnnot, ideo) {\n  var chrs, chr,\n    chrWidths = {},\n    chrWidth = ideo.config.chrWidth;\n\n  chrs = ideo.chromosomes[ideo.config.taxid];\n  for (chr in chrs) {\n    chrWidths[chr] = chrs[chr];\n  }\n\n  chrAnnot.append('polygon')\n    // .attr('id', function(d, i) { return d.id; })\n    .attr('class', 'annot')\n    .attr('points', function(d) {\n      return getHistogramPoints(d, chrWidth, chrWidths, ideo);\n    })\n    .attr('fill', function(d) {return d.color;});\n}\n\nexport {getHistogramBars, writeHistogramAnnots};\n","/**\n * @fileoverview Functions for drawing a legend for genome annotations.\n * A legend consists of rows, each with a colored icon and a text label.\n * Icons may have different shapes.  A legend may also have a name.\n */\n\nimport {d3, getTextSize, round} from '../lib';\n\nvar legendStyle =\n  '#_ideogramLegend {font: 12px Arial; overflow: auto;} ' +\n  '#_ideogramLegend svg {float: left;} ' +\n  '#_ideogramLegend ul {' +\n    'position: relative; left: -14px; list-style: none; float: left; ' +\n    'padding-left: 10px; margin: 0 0 1em 0; width: auto; border: none;' +\n  '} ' +\n  '#_ideogramLegend li {float: none; margin: 0;}' +\n  '#_ideogramLegend ul span {position: relative; left: -15px;} ';\n\nexport function getIcon(row, ideo) {\n  var icon, triangleAttrs, circleAttrs, rectAttrs,\n    fill = 'fill=\"' + row.color + '\" style=\"stroke: #AAA;\"',\n    shape = row.shape;\n\n  triangleAttrs = 'd=\"m7,3 l -5 9 l 9 0 z\"';\n  circleAttrs = 'd=\"m2,9a 4.5,4.5 0 1,0 9,0a 4.5,4.5 0 1,0 -9,0\"';\n  rectAttrs = 'height=\"10\" width=\"10\"  y=\"3\"';\n\n  if ('shape' in row && ['circle', 'triangle'].includes(shape)) {\n    if (shape === 'circle') {\n      icon = '<path ' + circleAttrs + ' ' + fill + '></path>';\n    } else if (shape === 'triangle') {\n      var transform = '';\n      if (ideo.config.orientation === 'vertical') {\n        // Orient arrows in legend as they are in annotations\n        transform = ' transform=\"rotate(90, 7, 7)\"';\n      }\n      if (ideo.config.orientation === 'down') {\n        transform = ' transform=\"rotate(180, 7, 7)\"';\n      }\n      icon = '<path ' + triangleAttrs + transform + ' ' + fill + '></path>';\n    }\n  } else {\n    icon = '<rect ' + rectAttrs + ' ' + fill + '/>';\n  }\n\n  return icon;\n}\n\nfunction getListItems(labels, svg, list, nameHeight, ideo) {\n  var i, icon, y, row,\n    lineHeight = getLineHeight(ideo);\n\n  for (i = 0; i < list.rows.length; i++) {\n    row = list.rows[i];\n    labels += '<li>' + row.name + '</li>';\n    y = lineHeight * (i - 1) + nameHeight + 1;\n    if ('name' in list) y += lineHeight;\n    icon = getIcon(row, ideo);\n    const transform = 'translate(0, ' + y + ')';\n    svg += '<g transform=\"' + transform + '\">' + icon + '</g>';\n  }\n\n  return [labels, svg];\n}\n\nfunction getLineHeight(ideo) {\n  return round(getTextSize('A', ideo).height) * 2 + 0.5;\n}\n\n/**\n * Display a legend for genome annotations, using `legend` configuration option\n */\nfunction writeLegend(ideo) {\n  var i, legend, svg, labels, list, content,\n    config = ideo.config,\n    lineHeight = getLineHeight(ideo);\n\n  d3.select(config.container + ' #_ideogramLegend').remove();\n\n  legend = config.legend;\n  content = '';\n\n  for (i = 0; i < legend.length; i++) {\n    list = legend[i];\n    let nameHeight = lineHeight;\n    if (list.nameHeight) {\n      nameHeight = list.nameHeight;\n    }\n    let nameStyle = '';\n    if (nameHeight) {\n      nameStyle =\n        `style=\"height: ${nameHeight}px; ` +\n        `position: relative; ` +\n        `left: -${nameHeight - 5}px;\"`;\n    }\n    if ('name' in list) {\n      labels = `<div ${nameStyle}>` + list.name + `</div>`;\n    }\n    svg = '<svg id=\"_ideogramLegendSvg\" width=\"' + lineHeight + '\">';\n    [labels, svg] = getListItems(labels, svg, list, nameHeight, ideo);\n    svg += '</svg>';\n    content += svg + '<ul>' + labels + '</ul>';\n  }\n\n  var fontFamily = `font-family: ${config.fontFamily};`;\n  var lineHeightCss = `line-height: ${getLineHeight(ideo)}px;`;\n  legendStyle +=\n    `#_ideogramLegend {${fontFamily} ${lineHeightCss}}`;\n\n  var target = d3.select(config.container + ' #_ideogramOuterWrap');\n  target.append('style').html(legendStyle);\n  target.append('div').attr('id', '_ideogramLegend').html(content);\n}\n\nexport {writeLegend};\n","import {d3} from '../lib';\nimport {writeHistogramAnnots} from './histogram';\nimport {writeLegend} from './legend';\n\nfunction parseFriendlyAnnots(friendlyAnnots, rawAnnots) {\n  var i, j, annot, rawAnnot;\n\n  for (i = 0; i < friendlyAnnots.length; i++) {\n    annot = friendlyAnnots[i];\n\n    for (j = 0; j < rawAnnots.length; j++) {\n      if (annot.chr === rawAnnots[j].chr) {\n        rawAnnot = [\n          annot.name,\n          annot.start,\n          annot.stop - annot.start\n        ];\n        if ('color' in annot) rawAnnot.push(annot.color);\n        if ('shape' in annot) rawAnnot.push(annot.shape);\n        rawAnnots[j].annots.push(rawAnnot);\n        break;\n      }\n    }\n  }\n\n  return rawAnnots;\n}\n\nfunction parseFriendlyKeys(friendlyAnnots) {\n  var keys = ['name', 'start', 'length'];\n  if ('color' in friendlyAnnots[0]) {\n    keys.push('color');\n  }\n  if ('shape' in friendlyAnnots[0]) {\n    keys.push('shape');\n  }\n  return keys;\n}\n\n/**\n * Draws annotations defined by user\n */\nfunction drawAnnots(friendlyAnnots, layout, keep=false, isOtherLayout=false) {\n  var keys, chr,\n    rawAnnots = [],\n    ideo = this,\n    chrs = ideo.chromosomes[ideo.config.taxid]; // TODO: multiorganism\n\n  if (\n    'annots' in friendlyAnnots[0] || // When filtering\n    'values' in friendlyAnnots[0] // When drawing cached expression matrices\n  ) {\n    return ideo.drawProcessedAnnots(friendlyAnnots, layout);\n  }\n\n  for (chr in chrs) {\n    rawAnnots.push({chr: chr, annots: []});\n  }\n  rawAnnots = parseFriendlyAnnots(friendlyAnnots, rawAnnots);\n\n  keys = parseFriendlyKeys(friendlyAnnots);\n\n  ideo.rawAnnots = {keys: keys, annots: rawAnnots};\n\n  const processedAnnots = ideo.processAnnotData(ideo.rawAnnots);\n  if (!isOtherLayout) {\n    ideo.annots = processedAnnots;\n  } else {\n    ideo.annotsOther = processedAnnots;\n  }\n\n  ideo.drawProcessedAnnots(processedAnnots, layout, keep);\n}\n\nfunction getShapes(annotHeight) {\n  var triangle, circle, rectangle, r;\n\n  triangle =\n    'm0,0 l -' + annotHeight + ' ' + (2 * annotHeight) +\n    ' l ' + (2 * annotHeight) + ' 0 z';\n\n  // From http://stackoverflow.com/a/10477334, with a minor change (\"m -r, r\")\n  // Circles are supported natively via <circle>, but having it as a path\n  // simplifies handling triangles, circles and other shapes in the same\n  // D3 call\n  r = annotHeight;\n  circle =\n    'm -' + r + ', ' + r +\n    'a ' + r + ',' + r + ' 0 1,0 ' + (r * 2) + ',0' +\n    'a ' + r + ',' + r + ' 0 1,0 -' + (r * 2) + ',0';\n\n  rectangle =\n    'm0,0 l 0 ' + (2 * annotHeight) +\n    'l ' + annotHeight + ' 0' +\n    'l 0 -' + (2 * annotHeight) + 'z';\n\n  return {triangle: triangle, circle: circle, rectangle: rectangle};\n}\n\nfunction getChrAnnotNodes(filledAnnots, ideo) {\n  return d3.selectAll(ideo.selector + ' .chromosome')\n    .data(filledAnnots)\n    .selectAll('path.annot')\n    .data(function(d) {\n      return d.annots;\n    })\n    .enter();\n}\n\nfunction determineShape(d, shapes) {\n  if (!d.shape || d.shape === 'triangle') {\n    return shapes.triangle;\n  } else if (d.shape === 'circle') {\n    return shapes.circle;\n  } else if (d.shape === 'rectangle') {\n    return shapes.rectangle;\n  } else {\n    return d.shape;\n  }\n}\n\nfunction writeTrackAnnots(chrAnnot, ideo) {\n  var shapes,\n    annotHeight = ideo.config.annotationHeight;\n\n  shapes = getShapes(annotHeight);\n\n  chrAnnot.append('g')\n    .attr('id', function(d) {return d.domId;})\n    .attr('class', 'annot')\n    .attr('transform', function(d) {\n      var y = ideo.config.chrWidth + (d.trackIndex * annotHeight * 2);\n      return 'translate(' + d.px + ',' + y + ')';\n    })\n    .append('path')\n    .attr('d', function(d) {return determineShape(d, shapes);})\n    .attr('fill', function(d) {return d.color;})\n    .on('mouseover', function(event, d) {ideo.showAnnotTooltip(d, this);})\n    .on('mouseout', function() {ideo.startHideAnnotTooltipTimeout();})\n    .on('click', function(event, d) {ideo.onClickAnnot(d);});\n}\n\n/**\n * Overlaid annotations appear directly on chromosomes\n */\nfunction writeOverlayAnnots(chrAnnot, ideo) {\n  chrAnnot.append('polygon')\n    .attr('id', function(d) {return d.id;})\n    .attr('class', 'annot')\n    .attr('points', function(d) {\n      var x1, x2,\n        chrWidth = ideo.config.chrWidth;\n\n      if (d.stopPx - d.startPx > 1) {\n        x1 = d.startPx;\n        x2 = d.stopPx;\n      } else {\n        x1 = d.px - 0.5;\n        x2 = d.px + 0.5;\n      }\n\n      return (\n        x1 + ',' + chrWidth + ' ' + x2 + ',' + chrWidth + ' ' +\n        x2 + ',0 ' + x1 + ',0'\n      );\n    })\n    .attr('fill', function(d) {return d.color;})\n    .on('mouseover', function(event, d) {ideo.showAnnotTooltip(d, this);})\n    .on('mouseout', function() {ideo.startHideAnnotTooltipTimeout();});\n}\n\nfunction warnIfTooManyAnnots(layout, annots) {\n  var i, numAnnots;\n\n  if (!/heatmap/.test(layout) && layout !== 'histogram') {\n    numAnnots = 0;\n    for (i = 0; i < annots.length; i++) {\n      numAnnots += annots[i].annots.length;\n    }\n    if (numAnnots > 2000) {\n      console.warn(\n        'Rendering more than 2000 annotations in Ideogram?\\n' +\n        'Try setting \"annotationsLayout\" to \"heatmap\" or \"histogram\" in your ' +\n        'Ideogram configuration object for better layout and performance.'\n      );\n    }\n  }\n}\n\nfunction drawAnnotsByLayoutType(layout, annots, ideo) {\n  var filledAnnots, chrAnnot;\n\n  warnIfTooManyAnnots(layout, annots);\n\n  if (layout === 'histogram') annots = ideo.getHistogramBars(annots);\n\n  filledAnnots = ideo.fillAnnots(annots);\n\n  chrAnnot = getChrAnnotNodes(filledAnnots, ideo);\n\n  if (layout === 'tracks') {\n    writeTrackAnnots(chrAnnot, ideo);\n  } else if (layout === 'overlay') {\n    writeOverlayAnnots(chrAnnot, ideo);\n  } else if (layout === 'histogram') {\n    writeHistogramAnnots(chrAnnot, ideo);\n  }\n}\n\n/**\n * Draws genome annotations on chromosomes.\n * Annotations can be rendered as either overlaid directly\n * on a chromosome, or along one or more \"tracks\"\n * running parallel to each chromosome.\n */\nfunction drawProcessedAnnots(annots, layout, keep=false) {\n  var ideo = this;\n\n  if (!keep) {\n    d3.selectAll(ideo.selector + ' .annot').remove();\n  }\n\n  if (layout === undefined) layout = 'tracks';\n  if (ideo.config.annotationsLayout) layout = ideo.config.annotationsLayout;\n\n  if ('legend' in ideo.config) writeLegend(ideo);\n\n  if (/heatmap/.test(layout)) {\n    ideo.drawHeatmaps(annots);\n    return;\n  }\n\n  drawAnnotsByLayoutType(layout, annots, ideo);\n  if (ideo.onDrawAnnotsCallback) ideo.onDrawAnnotsCallback();\n}\n\nexport {drawAnnots, drawProcessedAnnots, getShapes};\n","import {d3} from '../lib';\n\nexport function writeSyntenicRegion(syntenies, regionID, ideo) {\n  return syntenies.append('g')\n    .attr('class', 'syntenicRegion')\n    .attr('id', regionID)\n    .on('click', function() {\n      var activeRegion = this;\n      var others = d3.selectAll(ideo.selector + ' .syntenicRegion')\n        .filter(function() {return (this !== activeRegion);});\n\n      others.classed('hidden', !others.classed('hidden'));\n    })\n    .on('mouseover', function() {\n      var activeRegion = this;\n      d3.selectAll(ideo.selector + ' .syntenicRegion')\n        .filter(function() {return (this !== activeRegion);})\n        .classed('ghost', true);\n    })\n    .on('mouseout', function() {\n      d3.selectAll(ideo.selector + ' .syntenicRegion')\n        .classed('ghost', false);\n    });\n}\n\nexport function writeSyntenicRegionPolygons(\n  syntenicRegion, x1, x2, r1, r2, regions\n) {\n  var color, opacity;\n\n  color = ('color' in regions) ? regions.color : '#CFC';\n  opacity = ('opacity' in regions) ? regions.opacity : 1;\n\n  syntenicRegion.append('polygon')\n    .attr('points',\n      x1 + ', ' + r1.startPx + ' ' +\n      x1 + ', ' + r1.stopPx + ' ' +\n      x2 + ', ' + r2.stopPx + ' ' +\n      x2 + ', ' + r2.startPx\n    )\n    .style('fill', color)\n    .style('fill-opacity', opacity);\n}\n\nexport function writeSyntenicRegionPolygonsHorizontal(\n  syntenicRegion, y1, y2, r1, r2, regions\n) {\n  var color, opacity;\n\n  color = ('color' in regions) ? regions.color : '#CFC';\n  opacity = ('opacity' in regions) ? regions.opacity : 1;\n\n  syntenicRegion.append('polygon')\n    .attr('points',\n      (r1.startPx - 15) + ', ' + y1 + ' ' +\n      (r1.stopPx - 15) + ', ' + y1 + ' ' +\n      (r2.stopPx - 15) + ', ' + y2 + ' ' +\n      (r2.startPx - 15) + ', ' + y2\n    )\n    .style('fill', color)\n    .style('fill-opacity', opacity);\n}\n\nexport function getRegionsR1AndR2(regions, ideo, xOffset = null) {\n  var r1, r2,\n    r1Offset, r2Offset;\n\n  r1 = regions.r1;\n  r2 = regions.r2;\n\n  if (typeof r1.chr === 'string') {\n    const taxids = ideo.config.taxids;\n    if (ideo.config.multiorganism) {\n      r1.chr = ideo.chromosomes[taxids[0]][r1.chr];\n      r2.chr = ideo.chromosomes[taxids[1]][r2.chr];\n    } else {\n      r1.chr = ideo.chromosomes[taxids[0]][r1.chr];\n      r2.chr = ideo.chromosomes[taxids[0]][r2.chr];\n    }\n  }\n\n  var r1ChrDom = document.querySelector('#' + r1.chr.id + '-chromosome-set');\n  var r1GenomeHorizontalXOffset = r1ChrDom.getCTM().e;\n  var r1GenomeVerticalXOffset = r1ChrDom.getCTM().f;\n  var r2ChrDom = document.querySelector('#' + r2.chr.id + '-chromosome-set');\n  // var r2GenomeOffset = r2ChrDom.getBoundingClientRect().top;\n  var r2GenomeHorizontalXOffset = r2ChrDom.getCTM().e;\n  var r2GenomeVerticalXOffset = r2ChrDom.getCTM().f;\n\n  if (xOffset === null) {\n    if (ideo.config.orientation === 'vertical') {\n      // When vertical collinear\n      // http://localhost:8080/examples/vanilla/compare-whole-genomes?chromosome-scale=absolute&orientation=vertical\n      r1Offset = r1GenomeVerticalXOffset - 12;\n      r2Offset = r2GenomeVerticalXOffset - 12;\n    } else {\n      // When horizontal collinear, e.g.\n      // http://localhost:8080/examples/vanilla/compare-whole-genomes?chromosome-scale=absolute&orientation=horizontal\n      r1Offset = r1GenomeHorizontalXOffset;\n      r2Offset = r2GenomeHorizontalXOffset;\n    }\n  } else {\n    // When horizontal parallel\n    r1Offset = xOffset;\n    r2Offset = xOffset;\n  }\n\n  r1.startPx = ideo.convertBpToPx(r1.chr, r1.start) + r1Offset;\n  r1.stopPx = ideo.convertBpToPx(r1.chr, r1.stop) + r1Offset;\n  r2.startPx = ideo.convertBpToPx(r2.chr, r2.start) + r2Offset;\n  r2.stopPx = ideo.convertBpToPx(r2.chr, r2.stop) + r2Offset;\n\n  return [r1, r2];\n}\n","import {d3} from '../lib';\nimport {\n  getRegionsR1AndR2, writeSyntenicRegionPolygons, writeSyntenicRegion\n} from './synteny-lib';\n\nfunction writeSyntenicRegionLines(syntenicRegion, x1, x2, r1, r2) {\n  syntenicRegion.append('line')\n    .attr('class', 'syntenyBorder')\n    .attr('x1', x1)\n    .attr('x2', x2)\n    .attr('y1', r1.startPx)\n    .attr('y2', r2.startPx);\n\n  syntenicRegion.append('line')\n    .attr('class', 'syntenyBorder')\n    .attr('x1', x1)\n    .attr('x2', x2)\n    .attr('y1', r1.stopPx)\n    .attr('y2', r2.stopPx);\n}\n\nfunction writeSyntenicRegions(syntenicRegions, syntenies, ideo) {\n  var i, regions, r1, r2, regionID, syntenicRegion, chrWidth, x1, x2;\n\n  for (i = 0; i < syntenicRegions.length; i++) {\n    regions = syntenicRegions[i];\n\n    [r1, r2] = getRegionsR1AndR2(regions, ideo);\n\n    regionID = (\n      r1.chr.id + '_' + r1.start + '_' + r1.stop + '_' +\n      '__' +\n      r2.chr.id + '_' + r2.start + '_' + r2.stop\n    );\n\n    syntenicRegion = writeSyntenicRegion(syntenies, regionID, ideo);\n\n    chrWidth = ideo.config.chrWidth;\n    x1 = chrWidth + 51;\n    x2 = chrWidth + 245; // Genomes are spaced ~200 pixels apart\n\n    writeSyntenicRegionPolygons(syntenicRegion, x1, x2, r1, r2, regions);\n    writeSyntenicRegionLines(syntenicRegion, x1, x2, r1, r2);\n  }\n}\n\nfunction reportPerformance(t0, ideo) {\n  var t1 = new Date().getTime();\n  if (ideo.config.debug) {\n    console.log('Time in drawSyntenicRegions: ' + (t1 - t0) + ' ms');\n  }\n}\n\n/**\n * Draws a trapezoid connecting a genomic range on\n * one chromosome to a genomic range on another chromosome;\n * a syntenic region.\n */\nfunction drawSyntenyCollinear(syntenicRegions, ideo) {\n  var syntenies,\n    t0 = new Date().getTime();\n\n  syntenies = d3.select(ideo.selector)\n    .insert('g', ':first-child')\n    .attr('class', 'synteny');\n\n  writeSyntenicRegions(syntenicRegions, syntenies, ideo);\n\n  reportPerformance(t0, ideo);\n}\n\nexport {drawSyntenyCollinear};\n","import {d3} from '../lib';\nimport {\n  getRegionsR1AndR2, writeSyntenicRegionPolygonsHorizontal, writeSyntenicRegion\n} from './synteny-lib';\n\nfunction writeSyntenicRegionLines(syntenicRegion, y1, y2, r1, r2) {\n  syntenicRegion.append('line')\n    .attr('class', 'syntenyBorder')\n    .attr('x1', r1.startPx - 15)\n    .attr('x2', r2.startPx - 15)\n    .attr('y1', y1)\n    .attr('y2', y2);\n\n  syntenicRegion.append('line')\n    .attr('class', 'syntenyBorder')\n    .attr('x1', r1.stopPx - 15)\n    .attr('x2', r2.stopPx - 15)\n    .attr('y1', y1)\n    .attr('y2', y2);\n}\n\nfunction writeSyntenicRegions(syntenicRegions, syntenies, ideo) {\n  var i, regions, r1, r2, regionID, syntenicRegion, chrWidth, y1, y2;\n\n  for (i = 0; i < syntenicRegions.length; i++) {\n    regions = syntenicRegions[i];\n\n    [r1, r2] = getRegionsR1AndR2(regions, ideo);\n\n    regionID = (\n      r1.chr.id + '_' + r1.start + '_' + r1.stop + '_' +\n      '__' +\n      r2.chr.id + '_' + r2.start + '_' + r2.stop\n    );\n\n    syntenicRegion = writeSyntenicRegion(syntenies, regionID, ideo);\n\n    chrWidth = ideo.config.chrWidth;\n    y1 = chrWidth + 31;\n    y2 = chrWidth + 191; // Genomes are spaced ~200 pixels apart\n\n    writeSyntenicRegionPolygonsHorizontal(\n      syntenicRegion, y1, y2, r1, r2, regions\n    );\n    writeSyntenicRegionLines(syntenicRegion, y1, y2, r1, r2);\n  }\n}\n\nfunction reportPerformance(t0, ideo) {\n  var t1 = new Date().getTime();\n  if (ideo.config.debug) {\n    console.log('Time in drawSyntenicRegions: ' + (t1 - t0) + ' ms');\n  }\n}\n\n/**\n * Draws a trapezoid connecting a genomic range on\n * one chromosome to a genomic range on another chromosome;\n * a syntenic region.\n */\nfunction drawSyntenyCollinearHorizontal(syntenicRegions, ideo) {\n  var syntenies,\n    t0 = new Date().getTime();\n\n  syntenies = d3.select(ideo.selector)\n    .insert('g', ':first-child')\n    .attr('class', 'synteny');\n\n  writeSyntenicRegions(syntenicRegions, syntenies, ideo);\n\n  reportPerformance(t0, ideo);\n}\n\nexport {drawSyntenyCollinearHorizontal};\n","import {d3} from '../lib';\nimport {drawSyntenyCollinear} from './synteny-collinear';\nimport {drawSyntenyCollinearHorizontal} from './synteny-collinear-horizontal';\nimport {\n  getRegionsR1AndR2, writeSyntenicRegionPolygons, writeSyntenicRegion\n} from './synteny-lib';\n\nfunction writeSyntenicRegionLines(syntenicRegion, x1, x2, r1, r2, regions) {\n\n  var stroke, width;\n  if (\n    Math.abs(r1.startPx - r1.startPx) < 2 &&\n    Math.abs(r1.stopPx - r1.stopPx) < 2\n  ) {\n    stroke = regions.color;\n    width = regions.width;\n  } else {\n    stroke = '';\n    width = '';\n  }\n\n  syntenicRegion.append('line')\n    .attr('class', 'syntenyBorder')\n    .attr('x1', x1)\n    .attr('x2', x2)\n    .attr('y1', r1.startPx)\n    .attr('y2', r2.startPx)\n    .style('stroke', stroke)\n    .style('stroke-width', width);\n\n  syntenicRegion.append('line')\n    .attr('class', 'syntenyBorder')\n    .attr('x1', x1)\n    .attr('x2', x2)\n    .attr('y1', r1.stopPx)\n    .attr('y2', r2.stopPx)\n    .style('stroke', stroke)\n    .style('stroke-width', stroke);\n}\n\nfunction writeSyntenicRegionLabels(syntenicRegion, x1, x2, r1, r2, regionId) {\n  var rangeIds = regionId.split('__').map(d => 'label_' + d);\n  if ('name' in r1) {\n    syntenicRegion.append('text')\n      .attr('id', rangeIds[0])\n      .attr('y', r1.startPx + 3)\n      .text(r1.name);\n    var r1Width =\n      document.querySelector('#' + rangeIds[0]).getBoundingClientRect().width;\n    d3.select('#' + rangeIds[0]).attr('x', x1 - 15 - r1Width);\n  }\n  if ('name' in r2) {\n    syntenicRegion.append('text')\n      .attr('id', rangeIds[1])\n      .text(r2.name)\n      .attr('x', x2 + 15)\n      .attr('y', r2.startPx + 3)\n      .text(r2.name);\n  }\n}\n\nfunction writeSyntenicRegions(syntenicRegions, syntenies, xOffset, ideo) {\n  var i, regions, r1, r2, regionID, syntenicRegion, chrWidth, x1, x2;\n\n  for (i = 0; i < syntenicRegions.length; i++) {\n    regions = syntenicRegions[i];\n\n    [r1, r2] = getRegionsR1AndR2(regions, ideo, xOffset);\n\n    regionID = (\n      r1.chr.id + '_' + r1.start + '_' + r1.stop + '_' +\n      '__' +\n      r2.chr.id + '_' + r2.start + '_' + r2.stop\n    );\n\n    syntenicRegion = writeSyntenicRegion(syntenies, regionID, ideo);\n\n    chrWidth = ideo.config.chrWidth;\n    x1 = ideo._layout.getChromosomeSetYTranslate(0);\n    x2 = ideo._layout.getChromosomeSetYTranslate(1) - chrWidth;\n\n    writeSyntenicRegionPolygons(syntenicRegion, x1, x2, r1, r2, regions);\n    writeSyntenicRegionLines(syntenicRegion, x1, x2, r1, r2, regions);\n    writeSyntenicRegionLabels(syntenicRegion, x1, x2, r1, r2, regionID);\n  }\n}\n\nfunction reportPerformance(t0, ideo) {\n  var t1 = new Date().getTime();\n  if (ideo.config.debug) {\n    console.log('Time in drawSyntenicRegions: ' + (t1 - t0) + ' ms');\n  }\n}\n\n/**\n * Draws a trapezoid connecting a genomic range on\n * one chromosome to a genomic range on another chromosome;\n * a syntenic region.\n */\nfunction drawSynteny(syntenicRegions) {\n  var syntenies, xOffset,\n    t0 = new Date().getTime(),\n    ideo = this,\n    config = ideo.config;\n\n  // Make synteny / orthologs readable from client apps\n  ideo.syntenicRegions = syntenicRegions;\n\n  if (\n    config.multiorganism &&\n    config.geometry === 'collinear'\n  ) {\n    if (config.orientation === 'vertical') {\n      return drawSyntenyCollinear(syntenicRegions, ideo);\n    } else {\n      return drawSyntenyCollinearHorizontal(syntenicRegions, ideo);\n    }\n  }\n\n  syntenies = d3.select(ideo.selector)\n    .insert('g', ':first-child')\n    .attr('class', 'synteny');\n\n  xOffset = ideo._layout.margin.left;\n\n  writeSyntenicRegions(syntenicRegions, syntenies, xOffset, ideo);\n\n  reportPerformance(t0, ideo);\n}\n\nexport {drawSynteny};\n","import {d3} from '../lib';\nimport collinearizeChromosomes from '../collinear';\n\n/**\n * Reset displayed tracks to those originally displayed\n */\nfunction restoreDefaultTracks() {\n  var ideo = this;\n  ideo.config.numAnnotTracks = ideo.config.annotationsNumTracks;\n  d3.selectAll(ideo.selector + ' .annot').remove();\n  ideo.drawAnnots(ideo.processAnnotData(ideo.rawAnnots));\n}\n\nfunction getDisplayedRawAnnotsByChr(annotsByChr, trackIndexes) {\n  var annot, displayedRawAnnotsByChr, annots, i, displayedAnnots, j,\n    trackIndex;\n\n  displayedRawAnnotsByChr = [];\n\n  // Filter displayed tracks by selected track indexes\n  for (i = 0; i < annotsByChr.length; i++) {\n    annots = annotsByChr[i];\n    displayedAnnots = [];\n    for (j = 0; j < annots.annots.length; j++) {\n      annot = annots.annots[j].slice(); // copy array by value\n      trackIndex = annot[3] + 1;\n      if (trackIndexes.includes(trackIndex)) {\n        annot[3] = trackIndexes.indexOf(trackIndex);\n        displayedAnnots.push(annot);\n      }\n    }\n    displayedRawAnnotsByChr.push({chr: annots.chr, annots: displayedAnnots});\n  }\n\n  return displayedRawAnnotsByChr;\n}\n\n/**\n * Adds or removes tracks from the displayed list of tracks.\n * Only works when raw annotations are dense.\n *\n * @param trackIndexes Array of indexes of tracks to display\n */\nfunction updateDisplayedTracks(trackIndexes) {\n  var displayedRawAnnotsByChr, displayedAnnots, rawAnnots,\n    ideo = this,\n    annotsByChr = ideo.rawAnnots.annots;\n\n  ideo.config.numAnnotTracks = trackIndexes.length;\n\n  displayedRawAnnotsByChr =\n    getDisplayedRawAnnotsByChr(annotsByChr, trackIndexes);\n  rawAnnots = {keys: ideo.rawAnnots.keys, annots: displayedRawAnnotsByChr};\n\n  if (ideo.config.geometry === 'collinear') {\n    collinearizeChromosomes(ideo);\n  }\n\n  displayedAnnots = ideo.processAnnotData(rawAnnots);\n\n  d3.selectAll(ideo.selector + ' .annot').remove();\n  ideo.displayedTrackIndexes = trackIndexes;\n  ideo.drawAnnots(displayedAnnots);\n\n  return displayedAnnots;\n}\n\nfunction getSetAnnotsByChr(annotsByChr, ideo) {\n  var i, j, annots, annot, setAnnots, trackIndexOriginal, numAvailTracks,\n    setAnnotsByChr = [];\n\n  numAvailTracks = 1;\n\n  for (i = 0; i < annotsByChr.length; i++) {\n    annots = annotsByChr[i];\n    setAnnots = [];\n    for (j = 0; j < annots.annots.length; j++) {\n      annot = annots.annots[j].slice();\n      trackIndexOriginal = annot[3];\n      if (trackIndexOriginal + 1 > numAvailTracks) {\n        numAvailTracks = trackIndexOriginal + 1;\n      }\n      annot.splice(4, 0, trackIndexOriginal);\n      setAnnots.push(annot);\n    }\n    setAnnotsByChr.push({chr: annots.chr, annots: setAnnots});\n  }\n\n  ideo.numAvailTracks = numAvailTracks;\n\n  return setAnnotsByChr;\n}\n\nfunction setOriginalTrackIndexes(rawAnnots) {\n  var keys, annotsByChr, setAnnotsByChr,\n    ideo = this;\n\n  keys = rawAnnots.keys;\n\n  // If this method is unnecessary, pass through\n  if (\n    keys.length < 4 ||\n    keys[3] !== 'trackIndex' ||\n    keys[4] === 'trackIndexOriginal'\n  ) {\n    return rawAnnots;\n  }\n\n  annotsByChr = rawAnnots.annots;\n  setAnnotsByChr = getSetAnnotsByChr(annotsByChr, ideo);\n\n  keys.splice(4, 0, 'trackIndexOriginal');\n  rawAnnots = {keys: keys, annots: setAnnotsByChr};\n  if (ideo.rawAnnots.metadata) rawAnnots.metadata = ideo.rawAnnots.metadata;\n\n  return rawAnnots;\n}\n\nexport {restoreDefaultTracks, setOriginalTrackIndexes, updateDisplayedTracks};\n","import {add2dAnnotsForChr} from './heatmap-2d';\nimport {setAnnotRanks} from './annotations';\n\n// Default colors for tracks of annotations\nvar colorMap = [\n  ['F00'], // If there is 1 track, then color it red.\n  ['F00', '88F'], // If 2 tracks, color one red and one light blue.\n  ['F00', 'CCC', '88F'], // If 3, color one red, one grey, one light blue.\n  ['F00', 'FA0', '0AF', '88F'], // And so on.\n  ['F00', 'FA0', 'CCC', '0AF', '88F'],\n  ['F00', 'FA0', '875', '578', '0AF', '88F'],\n  ['F00', 'FA0', '875', 'CCC', '578', '0AF', '88F'],\n  ['F00', 'FA0', '7A0', '875', '0A7', '578', '0AF', '88F'],\n  ['F00', 'FA0', '7A0', '875', 'CCC', '0A7', '578', '0AF', '88F'],\n  ['F00', 'FA0', '7A0', '875', '552', '255', '0A7', '578', '0AF', '88F']\n];\n\n/**\n * Ensure annotation containers are ordered by chromosome.\n */\nfunction orderAnnotContainers(annots, ideo) {\n  var unorderedAnnots, i, j, annot, chr, chrs;\n\n  unorderedAnnots = annots;\n  annots = [];\n  chrs = ideo.chromosomesArray;\n  for (i = 0; i < chrs.length; i++) {\n    chr = chrs[i].name;\n    for (j = 0; j < unorderedAnnots.length; j++) {\n      annot = unorderedAnnots[j];\n      if (annot.chr === chr) {\n        annots.push(annot);\n      }\n    }\n  }\n\n  return annots;\n}\n\n/**\n * Add client annotations, as in annotations-tracks.html\n */\nfunction addClientAnnot(annots, annot, ra, m, ideo) {\n  var annotTrack;\n\n  annot.trackIndex = ra[3];\n  annotTrack = ideo.config.annotationTracks[annot.trackIndex];\n  if (annotTrack.color) {\n    annot.color = annotTrack.color;\n  }\n  if (annotTrack.shape) {\n    annot.shape = annotTrack.shape;\n  }\n\n  annots[m].annots.push(annot);\n\n  return annots;\n}\n\n/**\n * Add sparse server annotations, as in annotations-track-filters.html\n */\nfunction addSparseServerAnnot(annot, ra, omittedAnnots, annots, m, ideo) {\n  var colors = colorMap[ideo.numAvailTracks - 1];\n\n  annot.trackIndex = ra[3];\n  annot.trackIndexOriginal = ra[4];\n  annot.color = '#' + colors[annot.trackIndexOriginal];\n\n  // Catch annots that will be omitted from display\n  if (annot.trackIndex > ideo.config.numTracks - 1) {\n    if (annot.trackIndex in omittedAnnots) {\n      omittedAnnots[annot.trackIndex].push(annot);\n    } else {\n      omittedAnnots[annot.trackIndex] = [annot];\n    }\n    return [annots, omittedAnnots];\n  }\n  annots[m].annots.push(annot);\n\n  return [annots, omittedAnnots];\n}\n\n/**\n * Basic client annotations, as in annotations-basic.html\n * and annotations-external.html\n */\nfunction addBasicClientAnnot(annots, annot, m, ideo) {\n  annot.trackIndex = 0;\n  if (!annot.color) {\n    annot.color = ideo.config.annotationsColor;\n  }\n  if (!annot.shape) {\n    annot.shape = 'triangle';\n  }\n  annots[m].annots.push(annot);\n\n  return annots;\n}\n\nfunction addAnnot(annot, keys, ra, omittedAnnots, annots, m, ideo) {\n\n  if (ideo.config.annotationTracks) {\n    annots = addClientAnnot(annots, annot, ra, m, ideo);\n  } else if (keys[3] === 'trackIndex' && ideo.numAvailTracks !== 1) {\n    [annots, omittedAnnots] =\n      addSparseServerAnnot(annot, ra, omittedAnnots, annots, m, ideo);\n  // } else if (\n  //   keys.length > 3 &&\n  //   keys[3] in {trackIndex: 1, color: 1, shape: 1} === false &&\n  //   keys[4] === 'trackIndexOriginal'\n  // ) {\n  //   annots = addDenseServerAnnot(keys, annots, annot, m);\n  } else {\n    annots = addBasicClientAnnot(annots, annot, m, ideo);\n  }\n\n  return [annots, omittedAnnots];\n}\n\nfunction getAnnotDomId(chrIndex, annotIndex) {\n  return '_c' + chrIndex + '_a' + annotIndex;\n}\n\nfunction addAnnotsForChr(annots, omittedAnnots, annotsByChr, chrModel,\n  m, keys, ideo) {\n  var j, k, annot, ra;\n\n  // Assign DOM ID if annots are rendered as individual DOM elements\n  const shouldAssignDomId = (\n    !ideo.config.annotationsLayout ||\n    ideo.config.annotationsLayout === 'tracks'\n  );\n\n  for (j = 0; j < annotsByChr.annots.length; j++) {\n    ra = annotsByChr.annots[j];\n    annot = {};\n\n    for (k = 0; k < keys.length; k++) {\n      annot[keys[k]] = ra[k];\n    }\n\n    annot.stop = annot.start + annot.length;\n\n    annot.chr = annotsByChr.chr;\n    annot.chrIndex = m;\n    annot.startPx = ideo.convertBpToPx(chrModel, annot.start);\n    annot.stopPx = ideo.convertBpToPx(chrModel, annot.stop);\n    annot.px = Math.round((annot.startPx + annot.stopPx) / 2);\n    if (shouldAssignDomId) annot.domId = getAnnotDomId(m, j);\n\n    [annots, omittedAnnots] =\n      addAnnot(annot, keys, ra, omittedAnnots, annots, m, ideo);\n  }\n\n  if (shouldAssignDomId) {\n    if (ideo.annotSortFunction) {\n      annots[m].annots = setAnnotRanks(annots[m].annots, ideo);\n      annots[m].annots.sort((a, b) => {\n        // Reverse-sort, so first annots are drawn last, and thus at top layer\n        return -ideo.annotSortFunction(a, b);\n      });\n    } else {\n      // Sort by genomic position, in ascending order\n      annots[m].annots.sort((a, b) => a[1] - b[1]);\n    }\n\n    for (j = 0; j < annots[m].annots.length; j++) {\n      annots[m].annots[j].domId = getAnnotDomId(m, j);\n    }\n  }\n\n  return [annots, omittedAnnots];\n}\n\nfunction warnOfUndefinedChromosome(annotsByChr) {\n  console.warn(\n    'Chromosome \"' + annotsByChr.chr + '\" undefined in ideogram; ' +\n    annotsByChr.annots.length + ' annotations not shown'\n  );\n}\n\nfunction addAnnots(rawAnnots, keys, ideo) {\n  var m, i, annotsByChr, chrModel,\n    annots = [],\n    omittedAnnots = {};\n\n  m = -1;\n  for (i = 0; i < rawAnnots.length; i++) {\n    annotsByChr = rawAnnots[i];\n    chrModel = ideo.chromosomes[ideo.config.taxid][annotsByChr.chr];\n\n    if (typeof chrModel === 'undefined') {\n      warnOfUndefinedChromosome(annotsByChr);\n      continue;\n    }\n\n    m++;\n    annots.push({chr: annotsByChr.chr, annots: []});\n\n    if (ideo.config.annotationsLayout !== 'heatmap-2d') {\n      [annots, omittedAnnots] =\n        addAnnotsForChr(annots, omittedAnnots, annotsByChr, chrModel, m,\n          keys, ideo);\n    } else {\n      [annots, omittedAnnots] =\n        add2dAnnotsForChr(annots, omittedAnnots, annotsByChr, chrModel, m,\n          keys, ideo);\n    }\n  }\n  return [annots, omittedAnnots];\n}\n\nfunction sendTrackAndAnnotWarnings(omittedAnnots, ideo) {\n  var numOmittedTracks,\n    layout = ideo.config.annotationsLayout,\n    numTracks = ideo.config.numAnnotTracks;\n\n  if (!/heatmap/.test(layout) && numTracks > 10) {\n    console.error(\n      'Ideogram only displays up to 10 tracks at a time.  ' +\n      'You specified ' + numTracks + ' tracks.  ' +\n      'Perhaps consider a different way to visualize your data.'\n    );\n  }\n\n  numOmittedTracks = Object.keys(omittedAnnots).length;\n  if (numOmittedTracks) {\n    console.warn(\n      'Ideogram configuration specified ' + numTracks + ' tracks, ' +\n      'but loaded annotations contain ' + numOmittedTracks + ' ' +\n      'extra tracks.'\n    );\n  }\n}\n\n/**\n * Proccesses genome annotation data.\n *\n * This method converts raw annotation data from server, which is structured as\n * an array of arrays, into a more verbose data structure consisting of an\n * array of objects.  It also adds pixel offset information.\n */\nfunction processAnnotData(rawAnnots) {\n  var keys, annots, omittedAnnots,\n    ideo = this;\n\n  keys = rawAnnots.keys;\n  rawAnnots = rawAnnots.annots;\n\n  [annots, omittedAnnots] = addAnnots(rawAnnots, keys, ideo);\n  annots = orderAnnotContainers(annots, ideo);\n\n  sendTrackAndAnnotWarnings(omittedAnnots, ideo);\n\n  return annots;\n}\n\nexport {processAnnotData, getAnnotDomId};\n","/**\n * @fileoverview Parse raw Ideogram.js annotations from an expression matrix.\n * This module handles dense gene expression matrixes.\n * In gene expression expressions, rows are genes and columns are cells.\n */\n\nexport class ExpressionMatrixParser {\n\n  /**\n   * @param {String} matrix Tab-delimited gene expression matrix\n   * @param {Object} coordinates Coordinates [chr, start, length] by gene name\n   * @param {Object} ideo Ideogram object\n   */\n  constructor(matrix, ideo) {\n    this.matrix = matrix;\n    this.ideo = ideo;\n  }\n\n  /**\n   * Initialize rawAnnots by fetching genomic coordinates, then merging them\n   * with the gene expression matrix supplied in constructor.\n   */\n  setRawAnnots() {\n    var parser, ideo, matrix;\n    parser = this;\n    ideo = this.ideo;\n    matrix = this.matrix;\n\n    return new Promise(function(resolve) {\n      parser.rawAnnots = parser.fetchCoordinates(ideo)\n        .then(function(coordinates) {\n          parser.coordinates = coordinates;\n          resolve(parser.parseExpressionMatrix(matrix, ideo));\n        });\n    });\n  }\n\n  /**\n   * Get chromosome, start and stop coordinates from genome annotation file\n   *\n   * TODO: Support non-human organisms\n   */\n  fetchCoordinates(ideo) {\n    var coordinates = {};\n\n    if (ideo.config.organism === 'human') {\n      var ensemblData =\n        ideo.config.dataDir +\n        '../../annotations/Homo_sapiens,_Ensembl_80.tsv';\n\n      return new Promise(function(resolve) {\n        ideo.fetch(ensemblData, 'text').then(function(data) {\n          // eslint-disable-next-line no-unused-vars\n          var tsvLines, i, start, stop, gene, chr, length;\n\n          tsvLines = data.split(/\\r\\n|\\n/).slice(1);\n          for (i = 0; i < tsvLines.length; i++) {\n            [start, stop, gene, , chr] = tsvLines[i].split(/\\s/g);\n            start = parseInt(start);\n            stop = parseInt(stop);\n            length = stop - start;\n            coordinates[gene] = [chr, start, length];\n          }\n          resolve(coordinates);\n        });\n      });\n    } else {\n      throw Error('Expression matrix parsing is only supported for human');\n    }\n  }\n\n  /**\n   * Parses an annotation from a tab-separated line of a matrix file\n   */\n  parseAnnotFromTsvLine(tsvLine, chrs) {\n    var annot, chrIndex, chr, start, gene, expressions,\n      columns = tsvLine.split(/\\s/g);\n\n    gene = columns[0];\n    if (gene in this.coordinates === false) return [null, null];\n\n    expressions = columns.slice(1).map(d => parseFloat(d));\n    [chr, start, length] = this.coordinates[gene];\n\n    chrIndex = chrs.indexOf(chr);\n    if (chrIndex === -1) return [null, null];\n\n    annot = [gene, start, length];\n    annot = annot.concat(expressions);\n\n    return [chrIndex, annot];\n  }\n\n  /**\n  * Parses a gene expression matrix file, returns raw annotations\n  */\n  parseExpressionMatrix(matrix, ideo) {\n    var i, chrs, rawAnnots, cells, line, chrIndex, annot, keys,\n      annots = [],\n      tsvLines = matrix.split(/\\r\\n|\\n/);\n\n    chrs = Object.keys(ideo.chromosomes[ideo.config.taxid]);\n    for (i = 0; i < chrs.length; i++) {\n      annots.push({chr: chrs[i], annots: []});\n    }\n\n    for (i = 1; i < tsvLines.length; i++) {\n      line = tsvLines[i];\n      [chrIndex, annot] = this.parseAnnotFromTsvLine(line, chrs);\n      if (chrIndex !== null) annots[chrIndex].annots.push(annot);\n    }\n\n    cells = tsvLines[0].split(/\\s/g);\n    keys = ['name', 'start', 'length'].concat(cells);\n    rawAnnots = {keys: keys, annots: annots};\n\n    return rawAnnots;\n  }\n\n}\n","function downloadAnnotations() {\n\n  const ideo = this;\n  const annots = {};\n\n  ideo.annots.forEach(chrAnnots => {\n    chrAnnots.annots.forEach(annot => {\n      const desc = ideo.annotDescriptions.annots[annot.name];\n\n      annots[annot.name] = [\n        annot.name, desc.ensemblId,\n        annot.chr, annot.start, annot.stop, annot.length,\n        desc.type\n      ];\n    });\n  });\n\n  const header = [\n    '# Gene name', 'Ensembl ID', 'Chromosome', 'Start', 'Stop', 'Length', 'Type'\n  ];\n  const rows = [header].concat(Object.values(annots));\n  const annotsTsv =\n    ideo.annotDescriptions.headers + '\\n#\\n' +\n    rows.map(row => row.join('\\t')).join('\\n');\n\n  const annotsHref =\n    'data:text/plain;charset=utf-8,' + encodeURIComponent(annotsTsv);\n\n  var evt = new MouseEvent('click', {\n    view: window,\n    bubbles: false,\n    cancelable: true\n  });\n\n  var a = document.createElement('a');\n  a.setAttribute('download', 'ideogram.tsv');\n  a.setAttribute('href', annotsHref);\n  a.setAttribute('target', '_blank');\n\n  // Enables easy testing\n  a.setAttribute('id', '_ideo-undisplayed-dl-annots-link');\n  a.setAttribute('style', 'display: none;');\n  document.body.appendChild(a);\n\n  a.dispatchEvent(evt);\n}\n\nexport {downloadAnnotations};\n","/**\n * @fileoverview Methods for ideogram annotations.\n * Annotations are graphical objects that represent features of interest\n * located on the chromosomes, e.g. genes or variations.  They can\n * appear beside a chromosome, overlaid on top of it, or between multiple\n * chromosomes.\n */\n\nimport {BedParser} from '../parsers/bed-parser';\nimport {TsvParser} from '../parsers/tsv-parser';\nimport {drawHeatmaps, deserializeAnnotsForHeatmap} from './heatmap';\nimport {inflateThresholds} from './heatmap-lib';\nimport {inflateHeatmaps} from './heatmap-collinear';\nimport {\n  onLoadAnnots, onDrawAnnots, startHideAnnotTooltipTimeout,\n  onWillShowAnnotTooltip, onDidShowAnnotTooltip, showAnnotTooltip, onClickAnnot\n} from './events';\n\nimport {\n  addAnnotLabel, removeAnnotLabel, fillAnnotLabels, clearAnnotLabels\n  // fadeOutAnnotLabels\n} from './labels';\n\nimport {drawAnnots, drawProcessedAnnots} from './draw';\nimport {getHistogramBars} from './histogram';\nimport {drawSynteny} from './synteny';\nimport {\n  restoreDefaultTracks, setOriginalTrackIndexes, updateDisplayedTracks\n} from './filter';\nimport {processAnnotData} from './process';\nimport {ExpressionMatrixParser} from '../parsers/expression-matrix-parser';\nimport {downloadAnnotations} from './download';\n\nfunction initNumTracksAndBarWidth(ideo, config) {\n\n  if (config.annotationTracks) {\n    ideo.config.numAnnotTracks = config.annotationTracks.length;\n  } else if (config.annotationsNumTracks) {\n    ideo.config.numAnnotTracks = config.annotationsNumTracks;\n  } else {\n    ideo.config.numAnnotTracks = 1;\n  }\n  ideo.config.annotTracksHeight =\n    config.annotationHeight * config.numAnnotTracks;\n\n  if (typeof config.barWidth === 'undefined') {\n    ideo.config.barWidth = 3;\n  }\n}\n\nfunction initTooltip(ideo, config) {\n  if (config.showAnnotTooltip !== false) {\n    ideo.config.showAnnotTooltip = true;\n  }\n\n  if (config.onWillShowAnnotTooltip) {\n    ideo.onWillShowAnnotTooltipCallback = config.onWillShowAnnotTooltip;\n  }\n\n  if (config.onDidShowAnnotTooltip) {\n    ideo.onDidShowAnnotTooltipCallback = config.onDidShowAnnotTooltip;\n  }\n}\n\nfunction initAnnotLabel(ideo, config) {\n  if (config.addAnnotLabel !== false) {\n    ideo.config.addAnnotLabel = true;\n  }\n\n  if (config.onWillAddAnnotLabel) {\n    ideo.onWillAddAnnotLabelCallback = config.onWillAddAnnotLabel;\n  }\n}\n\nfunction initAnnotHeight(ideo) {\n  var config = ideo.config;\n  var annotHeight;\n\n  if (!config.annotationHeight) {\n    if (config.annotationsLayout === 'heatmap') {\n      annotHeight = config.chrWidth - 1;\n    } else {\n      annotHeight = Math.round(config.chrHeight / 100);\n      if (annotHeight < 3) annotHeight = 3;\n    }\n    ideo.config.annotationHeight = annotHeight;\n  }\n}\n\n/**\n * Initializes various annotation settings.  Constructor help function.\n */\nfunction initAnnotSettings() {\n  var ideo = this,\n    config = ideo.config;\n\n  initAnnotHeight(ideo);\n\n  if (\n    config.annotationsPath || config.localAnnotationsPath ||\n    ideo.annots || config.annotations\n  ) {\n    initNumTracksAndBarWidth(ideo, config);\n  } else {\n    ideo.config.annotTracksHeight = 0;\n    ideo.config.numAnnotTracks = 0;\n  }\n\n  if (typeof config.annotationsColor === 'undefined') {\n    ideo.config.annotationsColor = '#F00';\n  }\n\n  if (config.onClickAnnot) {\n    ideo.onClickAnnotCallback = config.onClickAnnot;\n  }\n\n  initTooltip(ideo, config);\n  initAnnotLabel(ideo, config);\n}\n\nfunction validateAnnotsUrl(annotsUrl) {\n  var tmp, extension;\n\n  tmp = annotsUrl.split('?')[0].split('.');\n  extension = tmp[tmp.length - 1];\n\n  if (['bed', 'json', 'tsv'].includes(extension) === false) {\n    extension = extension.toUpperCase();\n    alert(\n      'Ideogram.js only supports BED and Ideogram JSON and TSV ' +\n      'at the moment.  ' +\n      'Sorry, check back soon for ' + extension + ' support!'\n    );\n    return;\n  }\n  return extension;\n}\n\n/** Find redundant chromosomes in raw annotations */\nfunction detectDuplicateChrsInRawAnnots(ideo) {\n  const seen = {};\n  const duplicates = [];\n  const chrs = ideo.rawAnnots.annots.map(annot => annot.chr);\n\n  chrs.forEach((chr) => {\n    if (chr in seen) duplicates.push(chr);\n    seen[chr] = 1;\n  });\n\n  if (duplicates.length > 0) {\n    const message =\n      `Duplicate chromosomes detected.\\n` +\n      `Chromosome list: ${chrs}.  Duplicates: ${duplicates}.\\n` +\n      `To fix this, edit your raw annotations JSON data to remove redundant ` +\n      `chromosomes.`;\n    throw Error(message);\n  }\n}\n\nfunction afterRawAnnots() {\n  var ideo = this,\n    config = ideo.config;\n\n  // Ensure annots are ordered by chromosome\n  ideo.rawAnnots.annots = ideo.rawAnnots.annots.sort(Ideogram.sortChromosomes);\n\n  if (ideo.onLoadAnnotsCallback) {\n    ideo.onLoadAnnotsCallback();\n  }\n\n  if (\n    'heatmapThresholds' in config ||\n    'metadata' in ideo.rawAnnots &&\n    'heatmapThresholds' in ideo.rawAnnots.metadata\n  ) {\n    if (config.annotationsLayout === 'heatmap') {\n      inflateHeatmaps(ideo);\n    } else if (config.annotationsLayout === 'heatmap-2d') {\n      ideo.config.heatmapThresholds = inflateThresholds(ideo);\n    }\n  }\n\n  if (config.heatmaps) {\n    ideo.deserializeAnnotsForHeatmap(ideo.rawAnnots);\n  }\n\n  detectDuplicateChrsInRawAnnots(ideo);\n}\n\n/**\n * Converts list of annotation-by-chromosome objects to list of annot objects\n */\nfunction flattenAnnots() {\n  const ideo = this;\n  return ideo.annots.reduce((accumulator, annots) => {\n    return [...accumulator, ...annots.annots];\n  }, []);\n}\n\n/**\n * Requests annotations URL via HTTP, sets ideo.rawAnnots for downstream\n * processing.\n *\n * @param annotsUrl Absolute or relative URL for native or BED annotations file\n */\nfunction fetchAnnots(annotsUrl) {\n  var extension, is2dHeatmap,\n    ideo = this,\n    config = ideo.config;\n\n  is2dHeatmap = config.annotationsLayout === 'heatmap-2d';\n\n  var extension = validateAnnotsUrl(annotsUrl);\n\n  if (annotsUrl.slice(0, 4) !== 'http' && !is2dHeatmap && extension !== 'tsv') {\n    ideo.fetch(annotsUrl)\n      .then(function(data) {\n        ideo.rawAnnotsResponse = data; // Preserve truly raw response content\n        ideo.rawAnnots = data; // Sometimes gets partially processed\n        ideo.afterRawAnnots();\n      });\n    return;\n  }\n\n  extension = (is2dHeatmap ? '' : extension);\n\n  ideo.fetch(annotsUrl, 'text')\n    .then(function(text) {\n      ideo.rawAnnotsResponse = text;\n      if (is2dHeatmap) {\n        var parser = new ExpressionMatrixParser(text, ideo);\n        parser.setRawAnnots().then(function(d) {\n          ideo.rawAnnots = d;\n          ideo.afterRawAnnots();\n        });\n      } else {\n        if (extension === 'tsv') {\n          ideo.rawAnnots = new TsvParser(text, ideo).rawAnnots;\n        } else if (extension === 'bed') {\n          ideo.rawAnnots = new BedParser(text, ideo).rawAnnots;\n        } else {\n          ideo.rawAnnots = JSON.parse(text);\n        }\n        ideo.afterRawAnnots();\n      }\n    });\n}\n\n/**\n * Fills out annotations data structure such that its top-level list of arrays\n * matches that of this ideogram's chromosomes list in order and number\n * Fixes https://github.com/eweitz/ideogram/issues/66\n */\nfunction fillAnnots(annots) {\n  var filledAnnots, chrs, chrArray, i, chr, annot, chrIndex;\n\n  filledAnnots = [];\n  chrs = [];\n  chrArray = this.chromosomesArray;\n\n  for (i = 0; i < chrArray.length; i++) {\n    chr = chrArray[i].name;\n    chrs.push(chr);\n    filledAnnots.push({chr: chr, annots: []});\n  }\n\n  for (i = 0; i < annots.length; i++) {\n    annot = annots[i];\n    chrIndex = chrs.indexOf(annot.chr);\n    if (chrIndex !== -1) {\n      filledAnnots[chrIndex] = annot;\n    }\n  }\n\n  return filledAnnots;\n}\n\nexport function applyRankCutoff(annots, cutoff, ideo) {\n  const rankedAnnots = sortAnnotsByRank(annots, ideo);\n\n  // Take the top N ranked genes, where N is `cutoff`\n  annots = rankedAnnots.slice(0, cutoff);\n\n  return annots;\n}\n\nexport function setAnnotRanks(annots, ideo) {\n  if ('geneCache' in ideo === false) return annots;\n\n  const ranks = ideo.geneCache.interestingNames;\n\n  return annots.map(annot => {\n    if (ranks.includes(annot.name)) {\n      annot.rank = ranks.indexOf(annot.name) + 1;\n    } else {\n      annot.rank = 1E10;\n    }\n    return annot;\n  });\n}\n\nexport function sortAnnotsByRank(annots, ideo) {\n\n  if (ideo) {\n    annots = setAnnotRanks(annots, ideo);\n  }\n  // Ranks annots by popularity\n  return annots.sort((a, b) => {\n\n    // // Search gene is most important, regardless of popularity\n    // if (a.color === 'red') return -1;\n    // if (b.color === 'red') return 1;\n\n    // Rank 3 is more important than rank 30\n    return a.rank - b.rank;\n  });\n}\n\nexport {\n  onLoadAnnots, onDrawAnnots, processAnnotData, restoreDefaultTracks,\n  updateDisplayedTracks, initAnnotSettings, fetchAnnots, drawAnnots,\n  getHistogramBars, drawHeatmaps, deserializeAnnotsForHeatmap, fillAnnots,\n  drawProcessedAnnots, drawSynteny, startHideAnnotTooltipTimeout,\n  showAnnotTooltip, onWillShowAnnotTooltip, onDidShowAnnotTooltip,\n  setOriginalTrackIndexes,\n  afterRawAnnots, onClickAnnot, downloadAnnotations, addAnnotLabel,\n  removeAnnotLabel, fillAnnotLabels, clearAnnotLabels, flattenAnnots\n  // fadeOutAnnotLabels\n};\n","/** Adds boxes behind a list of chromosomes; can indicate selection, etc. */\nfunction highlight(chrNames, color='red') {\n  const ideo = this;\n  const taxid = ideo.config.taxid;\n\n  const highlightsHtml = chrNames.map(chrName => {\n    const chrId = ideo.chromosomes[taxid][chrName].id;\n    const chrSet = `${ideo.selector} #${chrId}-chromosome-set`;\n    const chrDom = document.querySelector(chrSet);\n    const rect = chrDom.getBoundingClientRect();\n\n    const style = `style=\"\n      stroke-width: 1px;\n      stroke: ${color};\n      fill: ${color};\n      fill-opacity: 0.05;\n      position: absolute;\n      rx: 4;\n      ry: 4;\n      height: ${rect.width + 15}px;\n      width: ${rect.height + 15}px\"`;\n\n    const left = chrDom.transform.baseVal[1].matrix.f - 7.5;\n    const transform = `transform=\"rotate(90) translate(10, ${left})\"`;\n    const id = `id=\"ideo-highlight-${chrId}\"`;\n\n    return `<rect class=\"ideo-highlight\" ${id} ${style} ${transform}/>`;\n  }).join();\n\n  const ideoDom = document.querySelector(ideo.selector);\n  ideoDom.insertAdjacentHTML('afterBegin', highlightsHtml);\n}\n\n/** Removes highlight from a list of chromosomes (or all chromosomes)  */\nfunction unhighlight(chrNames) {\n  const ideo = this;\n\n  let highlightsSelector = `${ideo.selector} .ideo-highlight`;\n  if (typeof chrNames !== 'undefined') {\n    const taxid = ideo.config.taxid;\n    highlightsSelector = chrNames.map(chrName => {\n      const chrId = ideo.chromosomes[taxid][chrName].id;\n      return `${ideo.selector} #ideo-highlight-${chrId}`;\n    });\n  }\n\n  document.querySelectorAll(highlightsSelector).forEach((element) => {\n    element.remove();\n  });\n\n}\n\nexport {highlight, unhighlight};\n","import {d3, slug, fetchWithRetry} from '../lib';\n\n/**\n *  Returns NCBI Taxonomy identifier (taxid) for organism name\n */\nfunction getTaxidFromEutils(orgName, ideo) {\n  var taxonomySearch, taxid;\n\n  taxonomySearch = ideo.esearch + '&db=taxonomy&term=' + orgName;\n\n  return d3.json(taxonomySearch).then(function(data) {\n    var idlist = data.esearchresult.idlist;\n    if (idlist.length === 0) {\n      var warning =\n        'Organism \"' + orgName + '\" is generally unknown; it was not found ' +\n        'in the NCBI Taxonomy database.  If you did not intend to specify a ' +\n        'novel or custom taxon, then try using the organism\\'s ' +\n        'scientific name, e.g. Homo sapiens or Arabidopsis thaliana.';\n      throw warning;\n    } else {\n      taxid = data.esearchresult.idlist[0];\n      return [orgName, taxid];\n    }\n  });\n}\n\n/**\n * Returns organism common name given an NCBI Taxonomy ID\n *\n * @param taxid NCBI Taxonomy ID\n * @param callback Function to call upon completing ESearch request\n */\nfunction getOrganismFromEutils(taxid, callback) {\n  var organism, taxonomySearch,\n    ideo = this;\n\n  taxid = ideo.config.organism;\n\n  taxonomySearch = ideo.esummary + '&db=taxonomy&id=' + taxid;\n\n  d3.json(taxonomySearch).then(function(data) {\n    organism = data.result[String(taxid)].commonname;\n    ideo.config.organism = organism;\n    return callback(organism);\n  });\n}\n\nfunction setTaxidData(taxid, ideo) {\n\n  var dataDir, urlOrg, taxids;\n\n  if (ideo.assemblyIsAccession()) {\n    return new Promise(function(resolve) {\n      ideo.coordinateSystem = 'bp';\n      ideo.getAssemblyAndChromosomesFromEutils(taxid, resolve);\n    });\n  }\n\n  dataDir = ideo.config.dataDir;\n  urlOrg = slug(ideo.organisms[taxid].scientificName);\n\n  taxids = [taxid];\n\n  var fullyBandedTaxids = ['9606', '10090', '10116'];\n  if (fullyBandedTaxids.includes(taxid) && !ideo.config.showFullyBanded) {\n    urlOrg += '-no-bands';\n  }\n  var chromosomesUrl = dataDir + urlOrg + '.json';\n\n  var promise2 = new Promise((resolve, reject) => {\n    return fetchWithRetry(chromosomesUrl)\n      .then(response => {\n        return response.json().then(function(json) {\n          resolve(json);\n        });\n      })\n      .catch((errorMessage) => {\n        reject(errorMessage);\n      });\n  });\n\n  return promise2\n    .then(function(chrData) {\n      // Check if chromosome data exists locally.\n      // This is used for pre-processed centromere data,\n      // which is not accessible via EUtils.  See get_chromosomes.py.\n      var chrBands = chrData.chrBands\n\n      var asmAndChrTaxidsArray = [''],\n        chromosomes = [],\n        seenChrs = {},\n        chr, maxLength, splitBand, length;\n\n      ideo.bandData[chrData.taxid] = chrBands;\n\n      for (var i = 0; i < chrBands.length; i++) {\n        splitBand = chrBands[i].split(' ');\n        chr = splitBand[0];\n        length = splitBand.slice(-1)[0];\n        if (chr in seenChrs) {\n          continue;\n        } else {\n          chromosomes.push({name: chr, type: 'nuclear', length: length});\n          seenChrs[chr] = 1;\n        }\n      }\n      chromosomes = chromosomes.sort(Ideogram.sortChromosomes);\n      maxLength = {bp: 0, iscn: 0};\n      chromosomes.forEach(chr => {\n        if (chr.length > maxLength.bp) maxLength.bp = chr.length;\n      });\n      ideo.maxLength[taxid] = maxLength;\n      asmAndChrTaxidsArray.push(chromosomes);\n      asmAndChrTaxidsArray.push(taxids);\n      return asmAndChrTaxidsArray;\n    },\n    function() {\n      // If request in `then` errs (404), fetch data from EUtils\n      return new Promise(function(resolve) {\n        ideo.coordinateSystem = 'bp';\n        ideo.getAssemblyAndChromosomesFromEutils(taxid, resolve);\n      });\n    });\n}\n\nfunction setAssemblyAndChromosomes(taxid, resolve, ideo) {\n  var assembly, chrs, originalChrs, orgName, filteredChrs,\n    config = ideo.config;\n\n  setTaxidData(taxid, ideo)\n    .then(function(asmChrTaxidsArray) {\n      assembly = asmChrTaxidsArray[0];\n      chrs = asmChrTaxidsArray[1];\n\n      if ('chromosomes' in config === false || config.chromosomes === null) {\n        ideo.config.chromosomes = {};\n        ideo.config.chromosomes[taxid] = chrs;\n      } else {\n        if (config.multiorganism) {\n          if (taxid in config.chromosomes) {\n            // Encountered when either organism has centromere data\n            originalChrs = config.chromosomes[taxid];\n          } else {\n            // Encountered when neither organism has centromere data\n            orgName = slug(ideo.getScientificName(taxid));\n            ideo.config.chromosomes[taxid] =\n              config.chromosomes[orgName].slice();\n            originalChrs = ideo.config.chromosomes[taxid];\n            // delete ideo.config.chromosomes[orgName];\n          }\n        } else {\n          originalChrs = config.chromosomes;\n        }\n\n        filteredChrs = chrs.filter(d => originalChrs.includes(d.name));\n        ideo.config.chromosomes[taxid] = filteredChrs;\n      }\n      ideo.chromosomes[taxid] = ideo.config.chromosomes[taxid].slice();\n      ideo.organisms[taxid].assemblies = {\n        default: assembly\n      };\n      resolve();\n    });\n}\n\n/**\n * Determine if organism is natively supported, using its name.\n */\nfunction isOrganismSupported(org, ideo) {\n  var taxid, ideoOrg;\n\n  for (taxid in ideo.organisms) {\n    ideoOrg = ideo.organisms[taxid];\n    if (\n      taxid === slug(org) ||\n      slug(ideoOrg.commonName) === slug(org) ||\n      slug(ideoOrg.scientificName) === slug(org)\n    ) {\n      return true;\n    }\n  }\n\n  return false;\n}\n\n/**\n * Augment \"organisms\" metadata with for any requested organism that is\n * not natively supported (i.e., not in organism-metadata.js).\n*/\nfunction populateNonNativeOrg(orgs, ideo) {\n  var org, promise, i,\n    getTaxidFromEutilsPromises = [],\n    augmentedOrganismMetadata = {};\n\n  for (i = 0; i < orgs.length; i++) {\n    org = orgs[i];\n    if (isOrganismSupported(org, ideo) === false) {\n      promise = getTaxidFromEutils(org, ideo)\n        .then(function(orgNameAndTaxid) {\n\n          var taxid = orgNameAndTaxid[1],\n            orgName = orgNameAndTaxid[0],\n            name, scientificName;\n\n          name = orgName.replace('-', ' ');\n          scientificName = name[0].toUpperCase() + name.slice(1);\n\n          augmentedOrganismMetadata[taxid] = {\n            scientificName: scientificName,\n            commonName: '',\n            assemblies: {default: ''}\n          };\n\n          Object.assign(ideo.organisms, augmentedOrganismMetadata);\n        }, function(warning) {\n          console.warn(warning);\n          var customMetadata = {\n            scientificName: org,\n            commonName: org,\n            assemblies: {default: ''}\n          };\n\n          // Use a negative number as unofficial taxid for custom organism.\n          // Use case: https://github.com/eweitz/ideogram/issues/265\n          //\n          // If support for *multiple* custom specifies is ever\n          // needed, we can decrement from -1.\n          ideo.organisms['-1'] = customMetadata;\n          augmentedOrganismMetadata['-1'] = customMetadata;\n        });\n    } else {\n      promise = new Promise(function(resolve) {\n        var taxid = ideo.getTaxid(org);\n        augmentedOrganismMetadata[taxid] = ideo.organisms[taxid];\n        resolve();\n      });\n    }\n    getTaxidFromEutilsPromises.push(promise);\n  }\n\n  return Promise.all(getTaxidFromEutilsPromises).then(function() {\n    return augmentedOrganismMetadata;\n  });\n}\n\nfunction prepareTmpChrsAndTaxids(ideo) {\n  var orgs, taxids, tmpChrs, org, taxid, chrsOrgSlugs,\n    config = ideo.config;\n\n  taxids = [];\n  tmpChrs = {};\n  orgs = (config.multiorganism) ? config.organism : [config.organism];\n\n  return populateNonNativeOrg(orgs, ideo).then(function(orgMetadata) {\n    var orgFields = orgMetadata[taxid];\n\n    for (taxid in orgMetadata) {\n      orgFields = orgMetadata[taxid];\n      taxids.push(taxid);\n      if (config.multiorganism) {\n        if (typeof config.chromosomes !== 'undefined') {\n          chrsOrgSlugs = Object.keys(config.chromosomes).map(org => slug(org));\n          // Adjusts 'chromosomes' configuration parameter to make object\n          // keys use taxid instead of common organism name\n          if (chrsOrgSlugs.includes(slug(orgFields.scientificName))) {\n            org = orgFields.scientificName;\n          } else if (chrsOrgSlugs.includes(slug(orgFields.commonName))) {\n            org = orgFields.commonName;\n          }\n          if (slug(org) in config.chromosomes) {\n            tmpChrs[taxid] = config.chromosomes[slug(org)];\n          } else {\n            tmpChrs[taxid] = config.chromosomes[org.toLowerCase()];\n          }\n        } else {\n          tmpChrs = null;\n        }\n      }\n    }\n    return [tmpChrs, taxids];\n  });\n}\n\n/**\n * Sort taxids by the \"organism\" configuration option\n *\n * TODO: Handle taxid being passed as organism\n */\nfunction sortTaxidsByOriginalOrganismOption(ideo) {\n  var configOrganisms, sortedTaxids, i;\n  configOrganisms = ideo.config.organism;\n  sortedTaxids = [];\n  if (Array.isArray(configOrganisms)) {\n    // Handling multi-organism ideogram\n    for (i = 0; i < configOrganisms.length; i++) {\n      sortedTaxids.push(ideo.getTaxid(configOrganisms[i]));\n    }\n  } else {\n    // Handling single-organism ideogram\n    sortedTaxids.push(ideo.getTaxid(configOrganisms));\n  }\n  return sortedTaxids;\n}\n\nfunction getTaxidsForOrganismsInConfig(callback, ideo) {\n\n  prepareTmpChrsAndTaxids(ideo).then(function([tmpChrs, taxids]) {\n    var i, taxid, promise, assemblies, asmAccs,\n      config = ideo.config,\n      asmAndChrPromises = [];\n\n    for (i = 0; i < taxids.length; i++) {\n      taxid = taxids[i];\n      assemblies = ideo.organisms[taxid].assemblies;\n      asmAccs = Object.values(assemblies);\n      if (\n        assemblies.default === '' ||\n        ideo.assemblyIsAccession() && !asmAccs.includes(config.assembly)\n      ) {\n        promise = new Promise(function(resolve) {\n          setAssemblyAndChromosomes(taxid, resolve, ideo);\n        });\n      } else {\n        ideo.config.taxids = taxids;\n        if (ideo.config.multiorganism) {\n          ideo.config.chromosomes = tmpChrs;\n        }\n        promise = new Promise(function(resolve) {\n          resolve();\n        });\n      }\n\n      asmAndChrPromises.push(promise);\n    }\n\n    Promise.all(asmAndChrPromises).then(function() {\n      taxids = sortTaxidsByOriginalOrganismOption(ideo);\n      ideo.config.taxids = taxids;\n      return callback(taxids);\n    });\n  });\n}\n\nfunction getIsMultiorganism(taxidInit, ideo) {\n  return (\n    ('organism' in ideo.config && ideo.config.organism instanceof Array) ||\n    (taxidInit && ideo.config.taxid instanceof Array)\n  );\n}\n\n/**\n * Configure Ideogram taxids when 'organism' is not in ideo.config\n */\nfunction getTaxidsForOrganismsNotInConfig(taxidInit, callback, ideo) {\n  var taxids;\n\n  if (ideo.config.multiorganism) {\n    if (taxidInit) {\n      taxids = ideo.config.taxid;\n    }\n  } else {\n    if (taxidInit) {\n      taxids = [ideo.config.taxid];\n    }\n    ideo.config.taxids = taxids;\n  }\n  callback(taxids);\n}\n\n/**\n * Returns an array of taxids for the current ideogram\n * Also sets configuration parameters related to taxid(s), whether ideogram is\n * multiorganism, and adjusts chromosomes parameters as needed\n **/\nfunction getTaxids(callback) {\n  var taxidInit,\n    ideo = this;\n\n  taxidInit = 'taxid' in ideo.config;\n\n  ideo.config.multiorganism = getIsMultiorganism(taxidInit, ideo);\n\n  if (ideo.config.multiorganism) ideo.coordinateSystem = 'bp';\n\n  if ('organism' in ideo.config) {\n    const org = ideo.config.organism;\n    if (typeof org === 'string') {\n      // Canonicalize e.g. \"Homo sapiens\" to \"homo-sapiens\"\n      ideo.config.organism = slug(org.toLowerCase());\n    }\n\n    getTaxidsForOrganismsInConfig(callback, ideo);\n  } else {\n    getTaxidsForOrganismsNotInConfig(taxidInit, callback, ideo);\n  }\n}\n\nexport {\n  getTaxids, getOrganismFromEutils\n};\n","import {d3} from '../lib';\nimport {\n  esearch, esummary, elink, getAssemblySearchUrl\n} from './eutils-config.js';\nimport {\n  getTaxids, getOrganismFromEutils\n} from './organisms.js';\n\n/**\n * Get a URL to ESearch the NCBI Nucleotide DB for an Assembly UID\n */\nfunction getESearchUrlForChromosomes(asmUid, ideo) {\n  var qs;\n\n  // Get a list of IDs for the chromosomes in this genome.\n  //\n  // Query chromosomes sequences in Nucleotide DB (nuccore) via\n  // Assembly DB E-Utils link.\n  qs = ('&db=nuccore&dbfrom=assembly&linkname=assembly_nuccore&' +\n    'cmd=neighbor_history&from_uid=' + asmUid);\n\n  return d3.json(ideo.elink + qs)\n    .then(function(data) {\n      var webenv = data.linksets[0].webenv;\n      qs =\n        '&db=nuccore' +\n        '&term=%231+AND+%28' +\n          'sequence_from_chromosome[Properties]+OR+' +\n          'sequence_from_plastid[Properties]+OR+' +\n          'sequence_from_mitochondrion[Properties]%29' +\n        '&WebEnv=' + webenv + '&usehistory=y&retmax=1000';\n      return ideo.esearch + qs;\n    });\n}\n\n/**\n * Request basic data on a list of chromosome IDs from ESearch\n */\nfunction fetchNucleotideSummary(data, ideo) {\n  var ids, ntSummary;\n  ids = data.esearchresult.idlist.join(',');\n  ntSummary = ideo.esummary + '&db=nucleotide&id=' + ids;\n  return d3.json(ntSummary);\n}\n\n/**\n * Get name and type for mitochondrial chromosome\n *\n * See example of \"MT\" in yeast:\n * https://eweitz.github.io/ideogram/eukaryotes?org=saccharomyces-cerevisiae\n */\nfunction parseMitochondrion(result, ideo) {\n  var type, cnIndex, chrName;\n\n  if (ideo.config.showNonNuclearChromosomes) {\n    type = result.genome;\n    cnIndex = result.subtype.split('|').indexOf('plasmid');\n    if (cnIndex === -1) {\n      chrName = 'MT';\n    } else {\n      // Seen in e.g. rice genome IRGSP-1.0 (GCF_001433935.1),\n      // From https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?retmode=json&db=nucleotide&id=996703432,996703431,996703430,996703429,996703428,996703427,996703426,996703425,996703424,996703423,996703422,996703421,194033210,11466763,7524755\n      // genome: 'mitochondrion',\n      // subtype: 'cell_line|plasmid',\n      // subname: 'A-58 CMS|B1',\n      chrName = result.subname.split('|')[cnIndex];\n    }\n  } else {\n    return [null, null];\n  }\n\n  return [chrName, type];\n}\n\n/**\n * Get name and type for chloroplastic chromosome.\n *\n * Plants have chloroplasts.  See e.g. green algae:\n * https://eweitz.github.io/ideogram/eukaryotes?org=micromonas-commoda\n */\nfunction parseChloroplastOrPlastid(ideo) {\n  // Plastid encountered with rice genome IRGSP-1.0 (GCF_001433935.1)\n  if (ideo.config.showNonNuclearChromosomes) {\n    return ['CP', 'chloroplast'];\n  }\n  return [null, null];\n}\n\n/**\n * Get name and type for apicoplast chromosome\n *\n * Plasmodium falciparum (malaria parasite) has such a chromosome, see e.g.:\n * https://eweitz.github.io/ideogram/eukaryotes?org=plasmodium-falciparum\n */\nfunction parseApicoplast(ideo) {\n  if (ideo.config.showNonNuclearChromosomes) {\n    return ['AP', 'apicoplast'];\n  }\n  return [null, null];\n}\n\n/**\n * Get name and type for nuclear chromosome\n *\n * These are typical chromosomes, like chromosome 1.\n */\nfunction parseNuclear(result) {\n  var type, cnIndex, chrName;\n\n  type = 'nuclear';\n  cnIndex = result.subtype.split('|').indexOf('chromosome');\n  chrName = result.subname.split('|')[cnIndex];\n\n  if (typeof chrName !== 'undefined' && chrName.substr(0, 3) === 'chr') {\n    // Convert \"chr12\" to \"12\", e.g. for banana (GCF_000313855.2)\n    chrName = chrName.substr(3);\n  }\n\n  return [chrName, type];\n}\n\n/**\n * Get name and type of any chromosome object from NCBI Nucleotide ESummary\n */\nfunction getChrNameAndType(result, ideo) {\n  var genome = result.genome;\n  if (genome === 'mitochondrion') {\n    return parseMitochondrion(result, ideo);\n  } else if (genome === 'chloroplast' || genome === 'plastid') {\n    return parseChloroplastOrPlastid(ideo);\n  } else if (genome === 'apicoplast') {\n    return parseApicoplast(ideo);\n  } else {\n    return parseNuclear(result);\n  }\n}\n\nfunction parseChromosome(result, ideo) {\n  var chrName, type, chromosome;\n\n  [chrName, type] = getChrNameAndType(result, ideo);\n\n  chromosome = {\n    name: chrName,\n    length: result.slen,\n    type: type\n  };\n\n  return chromosome;\n}\n\nfunction parseChromosomes(results, taxid, ideo) {\n  var x, chromosome, seenChrId, maxLength,\n    seenChrs = {},\n    chromosomes = [];\n\n  for (x in results) {\n    // omit list of result uids\n    if (x === 'uids') continue;\n\n    chromosome = parseChromosome(results[x], ideo);\n    seenChrId = chromosome.name + '_' + chromosome.length;\n    if (chromosome.type !== null && seenChrId in seenChrs === false) {\n      // seenChrs accounts for duplicate chromosomes seen with\n      // pig (Sus scrofa), likely GenBank and RefSeq copies.\n      chromosomes.push(chromosome);\n    }\n\n    seenChrs[seenChrId] = 1;\n  }\n\n  chromosomes = chromosomes.sort(Ideogram.sortChromosomes);\n\n  maxLength = {bp: 0, iscn: 0};\n  chromosomes.forEach(chr => {\n    if (chr.length > maxLength.bp) maxLength.bp = chr.length;\n  });\n  if (maxLength.bp > ideo.maxLength.bp) ideo.maxLength.bp = maxLength.bp;\n  ideo.maxLength[taxid] = maxLength;\n  ideo.coordinateSystem = 'bp';\n\n  return chromosomes;\n}\n\n/**\n * Request ESummary data from an ESearch on a genome assembly\n */\nfunction fetchAssemblySummary(data, ideo) {\n  var asmUid, asmSummaryUrl;\n\n  // NCBI Assembly database's internal identifier (uid) for this assembly\n  asmUid = data.esearchresult.idlist[0];\n  asmSummaryUrl = ideo.esummary + '&db=assembly&id=' + asmUid;\n\n  return d3.json(asmSummaryUrl);\n}\n\n/**\n * Returns assembly accession, as well as names and lengths of chromosomes for\n * an organism's best-known genome assembly, or for a specified assembly.\n *\n * Gets data from NCBI EUtils web API.\n *\n * @param callback Function to call upon completion of this async method\n */\nfunction getAssemblyAndChromosomesFromEutils(taxid, callback) {\n  var assemblyAccession,\n    ideo = this;\n\n  // Search for assembly, then\n  // get summary of that assembly, then\n  // get search URL for chromosomes in that assembly, then\n  // get search results containing chromosome IDs, then\n  // get summaries of each of those chromosome IDs, then\n  // format the chromosome summaries and pass them into callback function.\n  var asmSearchUrl = getAssemblySearchUrl(taxid, ideo);\n  d3.json(asmSearchUrl)\n    .then(function(data) {return fetchAssemblySummary(data, ideo);})\n    .then(function(data) {\n      var asmUid = data.result.uids[0];\n      assemblyAccession = data.result[asmUid];\n      return getESearchUrlForChromosomes(asmUid, ideo);\n    }).then(function(esearchUrl) {return d3.json(esearchUrl);})\n    .then(function(data) {return fetchNucleotideSummary(data, ideo);})\n    .then(function(data) {\n      var chromosomes = parseChromosomes(data.result, taxid, ideo);\n      return callback([assemblyAccession, chromosomes]);\n    }, function(rejectedReason) {\n      console.warn(rejectedReason);\n    });\n}\n\nexport {\n  esearch, esummary, elink, getOrganismFromEutils,\n  getTaxids, getAssemblyAndChromosomesFromEutils\n};\n","// The E-Utilies In Depth: Parameters, Syntax and More:\n// https://www.ncbi.nlm.nih.gov/books/NBK25499/\n\nvar apiKey = '&api_key=7e33ac6a08a6955ec3b83d214d22b21a2808';\n\nvar eutils = 'https://eutils.ncbi.nlm.nih.gov/entrez/eutils/';\nvar esearch = eutils + 'esearch.fcgi?retmode=json' + apiKey;\nvar esummary = eutils + 'esummary.fcgi?retmode=json' + apiKey;\nvar elink = eutils + 'elink.fcgi?retmode=json' + apiKey;\n\nfunction getAssemblySearchUrl(taxid, ideo) {\n  var termStem, asmSearchUrl;\n\n  if (ideo.assemblyIsAccession()) {\n    termStem = ideo.config.assembly + '%22[Assembly%20Accession]';\n  } else {\n    termStem = (\n      taxid + '%22[taxid]' +\n      'AND%20(%22latest%20refseq%22[filter])%20'\n    );\n  }\n\n  asmSearchUrl =\n    ideo.esearch +\n    '&db=assembly' +\n    '&term=%22' + termStem +\n    'AND%20(%22chromosome%20level%22[filter]%20' +\n    'OR%20%22complete%20genome%22[filter])';\n\n  return asmSearchUrl;\n}\n\nexport {esearch, esummary, elink, getAssemblySearchUrl};\n","/**\n * @fileoverview Methods to show (or hide) cytogenetic banding data\n */\n\nimport {d3} from '../lib';\n\nfunction hideUnshownBandLabels() {\n  var ideo = this;\n  var bandsToShow = ideo.bandsToShow.join(',');\n\n  // Handles edge-case when ideogram consists of one chromosome\n  // that lacks bands in a genome that has bands (e.g. MT in human)\n  if (ideo.bandsToShow.length === 0) return;\n\n  // d3.selectAll resolves to querySelectorAll (QSA).\n  // QSA takes a surprisingly long time to complete,\n  // and scales with the number of selectors.\n  // Most bands are hidden, so we can optimize by\n  // Hiding all bands, then QSA'ing and displaying the\n  // relatively few bands that are shown.\n  d3.selectAll(ideo.selector + ' .bandLabel, .bandLabelStalk')\n    .style('display', 'none');\n  d3.selectAll(bandsToShow).style('display', '');\n}\n\nfunction getPrevRight(prevLabelXRight, prevHiddenBoxIndex, i,\n  textOffsets, chrModel) {\n  var prevTextBoxLeft, prevTextBoxWidth;\n\n  if (prevHiddenBoxIndex !== i) {\n    // This getBoundingClientRect() forces Chrome's\n    // 'Recalculate Style' and 'Layout', which takes 30-40 ms on Chrome.\n    // TODO: This forced synchronous layout would be nice to eliminate.\n    // prevTextBox = texts[i].getBoundingClientRect();\n    // prevLabelXRight = prevTextBox.left + prevTextBox.width;\n\n    // TODO: Account for number of characters in prevTextBoxWidth,\n    // maybe also zoom.\n    prevTextBoxLeft = textOffsets[chrModel.id][i];\n    prevTextBoxWidth = 36;\n\n    prevLabelXRight = prevTextBoxLeft + prevTextBoxWidth;\n  }\n\n  return prevLabelXRight;\n}\n\nfunction updateShown(indexesToShow, overlapRight, left, pad, prevRight, i,\n  isBefore) {\n  var hiddenIndex, doSkip,\n    thisRight = isBefore ? overlapRight : prevRight;\n\n  if (left < pad + thisRight) {\n    overlapRight = prevRight;\n    hiddenIndex = i;\n    doSkip = isBefore;\n  } else {\n    indexesToShow.push(i);\n  }\n\n  return [indexesToShow, overlapRight, hiddenIndex, doSkip];\n}\n\nfunction getIndexesToShow(offsets, chrModel) {\n  var i, hiddenIndex, left, prevRight, doSkip,\n    indexesToShow = [],\n    textsLength = offsets[chrModel.id].length,\n    overlapRight = 0, // Right X coordinate of overlapping label\n    pad = 5; // text padding\n\n  for (i = 0; i < textsLength; i++) {\n    // Ensures band labels don't overlap\n    left = offsets[chrModel.id][i];\n\n    [indexesToShow, overlapRight, hiddenIndex, doSkip] =\n      updateShown(indexesToShow, overlapRight, left, pad, prevRight, i, true);\n    if (doSkip) continue;\n\n    prevRight = getPrevRight(prevRight, hiddenIndex, i, offsets, chrModel);\n\n    [indexesToShow, overlapRight, hiddenIndex, doSkip] =\n      updateShown(indexesToShow, overlapRight, left, pad, prevRight, i, false);\n  }\n\n  return indexesToShow;\n}\n\n/**\n * Sets band labels to display on each chromosome, avoiding label overlap\n */\nfunction setBandsToShow(chrs, textOffsets) {\n  var index, i, j, indexesToShow, chrModel, selectorsToShow, ithLength,\n    ideo = this;\n\n  ideo.bandsToShow = [];\n\n  for (i = 0; i < chrs.length; i++) {\n\n    chrModel = chrs[i];\n\n    indexesToShow = getIndexesToShow(textOffsets, chrModel);\n\n    selectorsToShow = [];\n    ithLength = indexesToShow.length;\n\n    for (j = 0; j < ithLength; j++) {\n      index = indexesToShow[j];\n      selectorsToShow.push('#' + chrModel.id + ' .bsbsl-' + index);\n    }\n\n    ideo.bandsToShow = ideo.bandsToShow.concat(selectorsToShow);\n  }\n}\n\nexport {hideUnshownBandLabels, setBandsToShow};\n","/**\n * @fileoverview Methods to draw cytogenetic bands and their labels\n *\n */\n\nimport {d3} from '../lib';\nimport {hideUnshownBandLabels, setBandsToShow} from './show';\nimport {staticColors, staticGradients} from './styles';\nimport {configuredCss} from './../init/configure';\n\n/**\n * Draws text of cytoband label\n */\nfunction drawBandLabelText(chr, bandsToLabel, chrModel, textOffsets) {\n  var ideo = this,\n    layout = ideo._layout,\n    chrIndex = chrModel.chrIndex;\n\n  chr.selectAll('text')\n    .data(bandsToLabel)\n    .enter()\n    .append('g')\n    .attr('class', function(d, i) {\n      return 'bandLabel bsbsl-' + i;\n    })\n    .attr('transform', function(d) {\n      var transform = layout.getChromosomeBandLabelTranslate(d, chrIndex);\n\n      if (ideo.config.orientation === 'horizontal') {\n        textOffsets[chrModel.id].push(transform.x + 13);\n      } else {\n        textOffsets[chrModel.id].push(transform.y + 6);\n      }\n\n      return transform.translate;\n    })\n    .append('text')\n    .attr('text-anchor', layout.getChromosomeBandLabelAnchor(chrIndex))\n    .text(function(d) {return d.name;});\n\n  return textOffsets;\n}\n\n/**\n * Draws line between cytoband and its text label\n */\nfunction drawBandLabelStalk(chr, bandsToLabel, chrModel, textOffsets) {\n  var ideo = this;\n\n  chr.selectAll('line.bandLabelStalk')\n    .data(bandsToLabel)\n    .enter()\n    .append('g')\n    .attr('class', function(d, i) {\n      return 'bandLabelStalk bsbsl-' + i;\n    })\n    .attr('transform', function(d) {\n      var x, y;\n\n      x = ideo.round(d.px.start + d.px.width / 2);\n      y = -10;\n\n      textOffsets[chrModel.id].push(x + 13);\n\n      return 'translate(' + x + ',' + y + ')';\n    })\n    .append('line')\n    .attr('x1', 0)\n    .attr('y1', ideo._layout.getChromosomeBandTickY1(chrModel.chrIndex))\n    .attr('x2', 0)\n    .attr('y2', ideo._layout.getChromosomeBandTickY2(chrModel.chrIndex));\n}\n\nfunction getChrModels(chromosomes) {\n  var taxid, chr,\n    chrModels = [];\n\n  for (taxid in chromosomes) {\n    for (chr in chromosomes[taxid]) {\n      chrModels.push(chromosomes[taxid][chr]);\n    }\n  }\n\n  return chrModels;\n}\n\n/**\n * Draws text and stalks for cytogenetic band labels.\n *\n * Band labels are text like \"p11.11\".\n * Stalks are small lines that visually connect labels to their bands.\n */\nfunction drawBandLabels(chromosomes) {\n  var i, chr, chrModel, chrModels, bandsToLabel,\n    ideo = this,\n    textOffsets = {};\n\n  chrModels = getChrModels(chromosomes);\n\n  for (i = 0; i < chrModels.length; i++) {\n    chrModel = chrModels[i];\n    chr = d3.select(ideo.selector + ' #' + chrModel.id);\n    textOffsets[chrModel.id] = [];\n\n    // Don't show \"pter\" label for telocentric chromosomes, e.g. mouse\n    bandsToLabel = chrModel.bands.filter(d => d.name !== 'pter');\n\n    textOffsets =\n      ideo.drawBandLabelText(chr, bandsToLabel, chrModel, textOffsets);\n\n    ideo.drawBandLabelStalk(chr, bandsToLabel, chrModel, textOffsets);\n  }\n\n  ideo.setBandsToShow(chrModels, textOffsets);\n}\n\nfunction getStainAndColors(i, colors) {\n  var stain, color1, color2, color3;\n\n  stain = colors[i][0];\n  color1 = colors[i][1];\n  color2 = colors[i][2];\n  color3 = colors[i][3];\n\n  return [stain, color1, color2, color3];\n}\n\nfunction getGradients(colors) {\n  var i, stain, color1, color2, color3,\n    gradients = '';\n\n  for (i = 0; i < colors.length; i++) {\n    [stain, color1, color2, color3] = getStainAndColors(i, colors);\n    gradients +=\n      '<linearGradient id=\"' + stain + '\" x1=\"0%\" y1=\"0%\" x2=\"0%\" y2=\"100%\">';\n    if (stain === 'gneg') {\n      gradients +=\n        '<stop offset=\"70%\" stop-color=\"' + color2 + '\" />' +\n        '<stop offset=\"95%\" stop-color=\"' + color3 + '\" />' +\n        '<stop offset=\"100%\" stop-color=\"' + color1 + '\" />';\n    } else {\n      gradients +=\n        '<stop offset=\"5%\" stop-color=\"' + color1 + '\" />' +\n        '<stop offset=\"15%\" stop-color=\"' + color2 + '\" />' +\n        '<stop offset=\"60%\" stop-color=\"' + color3 + '\" />';\n    }\n    gradients +=\n      '</linearGradient>';\n  }\n\n  return gradients;\n}\n\n/**\n * Returns SVG gradients that give chromosomes a polished look\n */\nfunction getBandColorGradients() {\n  var css,\n    gradients = '';\n\n  gradients = getGradients(staticColors);\n\n  css = `<style>${configuredCss}</style>`;\n\n  gradients += staticGradients;\n  gradients = '<defs>' + gradients + '</defs>';\n  gradients = css + gradients;\n\n  return gradients;\n}\n\nexport {\n  drawBandLabels, getBandColorGradients, hideUnshownBandLabels, setBandsToShow,\n  drawBandLabelText, drawBandLabelStalk\n};\n","\nfunction getDelimiterTsvLinesAndInit(source, content) {\n  var delimiter, tsvLines, init;\n\n  if (typeof chrBands === 'undefined' && source !== 'native') {\n    delimiter = /\\t/;\n    tsvLines = content.split(/\\r\\n|\\n/);\n    init = 1;\n  } else {\n    delimiter = / /;\n    tsvLines = content;\n    init = 0;\n  }\n\n  return [delimiter, tsvLines, init];\n}\n\nfunction updateChromosomes(chromosomes) {\n  var tmp, i;\n\n  if (chromosomes instanceof Array && typeof chromosomes[0] === 'object') {\n    tmp = [];\n    for (i = 0; i < chromosomes.length; i++) {\n      tmp.push(chromosomes[i].name);\n    }\n    chromosomes = tmp;\n  }\n  return chromosomes;\n}\n\nfunction getLineObject(chr, columns, stain, taxid) {\n  return {\n    chr: chr,\n    bp: {\n      start: parseInt(columns[5], 10),\n      stop: parseInt(columns[6], 10)\n    },\n    iscn: {\n      start: parseInt(columns[3], 10),\n      stop: parseInt(columns[4], 10)\n    },\n    px: {\n      start: -1,\n      stop: -1,\n      width: -1\n    },\n    name: columns[1] + columns[2],\n    stain: stain,\n    taxid: taxid\n  };\n}\n\nfunction getStain(columns) {\n  var stain = columns[7];\n  // For e.g. acen and gvar, columns[8] (density) is undefined\n  if (columns[8]) stain += columns[8];\n  return stain;\n}\n\nfunction updateLines(lines, columns, taxid) {\n  var chr, stain, line;\n\n  chr = columns[0];\n  if (chr in lines === false) lines[chr] = [];\n\n  stain = getStain(columns);\n\n  line = getLineObject(chr, columns, stain, taxid);\n  lines[chr].push(line);\n\n  return lines;\n}\n\n/**\n * Reports if a cytogenetic band should be included in parse results\n *\n * TODO:\n * Normalize ideogram.chromosomes upstream.\n *\n * This function is complex because ideogram.chromosomes is (likely\n * unnecessarily) complex.  The \"ideogram.chromosomes\" object can\n * take many forms depending on the use case, and this results in\n * hard-to-reason-about functions like this.\n *\n * Normalizing ideogram.chromosomes to a common format somewhere upstream\n * would likely make this specific function and Ideogram in general much\n * more maintainable.\n */\nfunction shouldSkipBand(chrs, chr, taxid, ideo) {\n\n  var hasChrs, chrsAreList, chrNotInList, chrsAreObject,\n    innerChrsAreStrings, matchingChrObjs, chrNotInObject,\n    multiorganism = ideo.config.multiorganism;\n\n  hasChrs = typeof chrs !== 'undefined' && chrs !== null;\n  if (!hasChrs) return false;\n\n  chrsAreList = Array.isArray(chrs);\n  chrNotInList = chrsAreList && chrs.indexOf(chr) === -1;\n  chrsAreObject = typeof chrs === 'object';\n\n  if (chrsAreList && !chrsAreObject && chrNotInList) return true;\n\n  if (taxid in chrs === false && multiorganism) return false;\n\n  if (!multiorganism) {\n    // Encountered in single organism when showing subset of all chromosomes,\n    // e.g. only human X and Y as in https://eweitz.github.io/ideogram/homology-basic\n    matchingChrObjs = chrs.filter(thisChr => thisChr === chr);\n    chrNotInObject = matchingChrObjs.length === 0;\n  } else {\n    innerChrsAreStrings = typeof chrs[taxid][0] === 'string';\n    if (innerChrsAreStrings) {\n      chrNotInObject = chrs[taxid].includes(chr) === false;\n    } else {\n      matchingChrObjs = chrs[taxid].filter(thisChr => thisChr.name === chr);\n      chrNotInObject = matchingChrObjs.length === 0;\n    }\n  }\n  return chrNotInObject;\n\n}\n\n/**\n * Parses cytogenetic band data from a TSV file, or, if band data is\n * prefetched, from an array\n *\n * NCBI:\n * #chromosome arm band iscn_start iscn_stop bp_start bp_stop stain density\n * ftp://ftp.ncbi.nlm.nih.gov/pub/gdp/ideogram_9606_GCF_000001305.14_550_V1\n */\nfunction parseBands(taxid, chromosomes, ideo) {\n  var delimiter, tsvLines, columns, chr, i, init, source, content,\n    lines = {};\n\n  content = ideo.bandData[taxid];\n\n  if (Array.isArray(content)) source = 'native';\n\n  chromosomes = updateChromosomes(chromosomes);\n\n  // Destructure assignment fails oddly when transpiled.  2019-05-23\n  var result = getDelimiterTsvLinesAndInit(source, content);\n  delimiter = result[0];\n  tsvLines = result[1];\n  init = result[2];\n\n  for (i = init; i < tsvLines.length; i++) {\n    columns = tsvLines[i].split(delimiter);\n\n    chr = columns[0];\n    if (shouldSkipBand(chromosomes, chr, taxid, ideo)) {\n      // If specific chromosomes are configured, then skip processing all\n      // other fetched chromosomes.\n      continue;\n    }\n\n    lines = updateLines(lines, columns, taxid);\n  }\n\n  return lines;\n}\n\nexport {parseBands};\n","/**\n * @fileoverview Methods for processing chromosome length and banding data.\n *\n * Ideogram.js depicts chromosomes using data on their length, name, and\n * (if dealing with a very well-studied organism) cytogenetic banding data.\n * This file processes cytoband data that comes from biological research\n * institutions.\n *\n * For background on cytogenetic bands and how they are used in genomics, see:\n * https://ghr.nlm.nih.gov/primer/howgeneswork/genelocation\n *\n */\n\nimport {\n  drawBandLabels, getBandColorGradients, hideUnshownBandLabels, setBandsToShow,\n  drawBandLabelText, drawBandLabelStalk\n} from './draw';\nimport {parseBands} from './parse';\nimport {organismMetadata} from '../init/organism-metadata';\n\n/**\n * Gets bands array for given chromosomes, sets ideo.maxLength\n */\nfunction getBandsArray(chromosome, bandsByChr, taxid, ideo) {\n  var bands, chrLength,\n    bandsArray = [];\n\n  bands = bandsByChr[chromosome];\n  bandsArray.push(bands);\n\n  chrLength = {\n    iscn: bands[bands.length - 1].iscn.stop,\n    bp: bands[bands.length - 1].bp.stop\n  };\n\n  if (taxid in ideo.maxLength === false) {\n    ideo.maxLength[taxid] = {bp: 0, iscn: 0};\n  }\n\n  if (chrLength.iscn > ideo.maxLength[taxid].iscn) {\n    ideo.maxLength[taxid].iscn = chrLength.iscn;\n    if (chrLength.iscn > ideo.maxLength.iscn) {\n      ideo.maxLength.iscn = chrLength.iscn;\n    }\n  }\n\n  if (chrLength.bp > ideo.maxLength[taxid].bp) {\n    ideo.maxLength[taxid].bp = chrLength.bp;\n    if (chrLength.bp > ideo.maxLength.bp) {\n      ideo.maxLength.bp = chrLength.bp;\n    }\n  }\n\n  return bandsArray;\n}\n\n/**\n * Updates bandsArray, sets ideo.config.chromosomes and ideo.numChromosomes\n */\nfunction setChrsByTaxidsWithBands(taxid, chrs, bandsArray, ideo) {\n  var bandsByChr, chromosome, k, chrBandsArray;\n\n  bandsByChr = parseBands(taxid, chrs, ideo);\n\n  chrs = Object.keys(bandsByChr).sort(Ideogram.sortChromosomes);\n\n  if (\n    'chromosomes' in ideo.config === false ||\n    ideo.config.chromosomes === null\n  ) {\n    ideo.config.chromosomes = {};\n  }\n  if (chrs.length > 0) {\n    ideo.config.chromosomes[taxid] = chrs.slice();\n  }\n  ideo.numChromosomes += ideo.config.chromosomes[taxid].length;\n\n  for (k = 0; k < chrs.length; k++) {\n    chromosome = chrs[k];\n    chrBandsArray = getBandsArray(chromosome, bandsByChr, taxid, ideo);\n    bandsArray = bandsArray.concat(chrBandsArray);\n  }\n\n  return bandsArray;\n}\n\nfunction setChromosomesByTaxid(taxid, chrs, bandsArray, ideo) {\n  var chr, i;\n\n  if (\n    taxid in ideo.bandData ||\n    taxid in organismMetadata &&\n    ideo.assemblyIsAccession() === false\n  ) {\n    bandsArray = setChrsByTaxidsWithBands(taxid, chrs, bandsArray, ideo);\n  } else {\n    // If lacking band-level data\n    ideo.numChromosomes += chrs.length;\n\n    for (i = 0; i < chrs.length; i++) {\n      chr = chrs[i];\n      if (chr.length > ideo.maxLength.bp) ideo.maxLength.bp = chr.length;\n    }\n  }\n\n  return bandsArray;\n}\n\nfunction reportPerformance(t0, ideo) {\n  var t1 = new Date().getTime();\n  if (ideo.config.debug) {\n    console.log('Time in processBandData: ' + (t1 - t0) + ' ms');\n  }\n}\n\n/**\n * Completes default ideogram initialization by calling downstream functions\n * to process raw band data into full JSON objects, render chromosome and\n * cytoband figures and labels, apply initial graphical transformations,\n * hide overlapping band labels, and execute callbacks defined by client code\n */\nfunction processBandData(taxid) {\n  var bandsArray, chrs,\n    ideo = this,\n    config = ideo.config,\n    t0 = new Date().getTime();\n\n  bandsArray = [];\n\n  if ('chromosomes' in config) {\n    if (config.multiorganism) {\n      // Copy object\n      chrs = config.chromosomes;\n    } else if (taxid in config.chromosomes) {\n      // Copy array by value\n      chrs = config.chromosomes[taxid].slice();\n    } else {\n      // Copy array by value.  Needed for e.g. \"Homology, basic\"\n      chrs = config.chromosomes.slice();\n    }\n  }\n\n  bandsArray = setChromosomesByTaxid(taxid, chrs, bandsArray, ideo);\n\n  reportPerformance(t0, ideo);\n  return [taxid, bandsArray];\n}\n\nexport {\n  drawBandLabels, getBandColorGradients, processBandData,\n  setBandsToShow, hideUnshownBandLabels, drawBandLabelText, drawBandLabelStalk\n};\n","/**\n * @fileoverview Methods to create and handle a brush on a chromosome.\n *\n * Ideogram.js enables users to display a box around part of a chromosome\n * that represents a \"currently selected\" region.  The user can move this\n * box like a sliding window, e.g. by clicking and dragging the mouse.\n *\n * For background, see:\n * https://github.com/d3/d3-brush\n */\n\nimport {d3} from './lib';\n\n/**\n * Custom event handler, fired upon dragging sliding window on chromosome\n */\nfunction onBrushMove() {\n  call(this.onBrushMoveCallback);\n}\n\nfunction onBrushEnd() {\n  call(this.onBrushEndCallback);\n}\n\nfunction setBrush(bpDomain, pxRange, xOffset, width, ideo) {\n  var xScale,\n    length = ideo.config.chrHeight;\n\n  xScale = d3.scaleLinear().domain(bpDomain).range(pxRange);\n\n  ideo.brush = d3.brushX()\n    .extent([[xOffset, 0], [length + xOffset, width]])\n    .on('brush', _onBrushMove)\n    .on('end', _onBrushEnd);\n\n  function _onBrushMove({selection}) {\n    var extent = selection.map(xScale.invert),\n      from = Math.floor(extent[0]),\n      to = Math.ceil(extent[1]);\n\n    ideo.selectedRegion = {from: from, to: to, extent: (to - from)};\n\n    if (ideo.onBrushMoveCallback) {\n      ideo.onBrushMoveCallback();\n    }\n  }\n\n  function _onBrushEnd({selection}) {\n    if (ideo.onBrushEndCallback) {\n      ideo.onBrushEndCallback();\n    }\n  }\n}\n\nfunction getBasePairDomainAndPixelRange(chrModel, xOffset) {\n  var band, i,\n    bpDomain = [1],\n    pxRange = [1],\n    lastBand = chrModel.bands.slice(-1)[0];\n\n  for (i = 0; i < chrModel.bands.length; i++) {\n    band = chrModel.bands[i];\n    bpDomain.push(band.bp.start);\n    pxRange.push(band.px.start + xOffset);\n  }\n\n  bpDomain.push(lastBand.bp.stop - 1);\n  pxRange.push(lastBand.px.stop + xOffset);\n\n  return [bpDomain, pxRange];\n}\n\n/**\n * Account for calls like createBrush('chr1:104325484-119977655')\n */\nfunction refineGenomicCoordinates(chr, from, to) {\n  var nameSplit, fromToSplit;\n\n  // Account for calls like createBrush('chr1:104325484-119977655')\n  nameSplit = chr.split(':');\n  fromToSplit = chr.split('-');\n  if (nameSplit.length > 1 && fromToSplit.length > 1) {\n    chr = nameSplit[0].replace('chr', '');\n    fromToSplit = nameSplit[1].split('-');\n    from = parseInt(fromToSplit[0]);\n    to = parseInt(fromToSplit[1] - 1);\n  }\n\n  return [chr, from, to];\n}\n\nfunction getChrModel(chr, ideo) {\n  var i, cm, chrModel;\n\n  for (i = 0; i < ideo.chromosomesArray.length; i++) {\n    cm = ideo.chromosomesArray[i];\n    if (cm.name === chr) {\n      chrModel = cm;\n      return chrModel;\n    }\n  }\n}\n\nfunction writeBrush(chrModel, from, to, xOffset, width, ideo) {\n  var x0, x1, yTranslate, yOffset;\n\n  x0 = ideo.convertBpToPx(chrModel, from) + xOffset;\n  x1 = ideo.convertBpToPx(chrModel, to) + xOffset;\n\n  yTranslate = ideo._layout.getChromosomeSetYTranslate(0);\n  yOffset = yTranslate + (ideo.config.chrWidth - width) / 2;\n\n  d3.select(ideo.selector).append('g')\n    .attr('class', 'brush')\n    .attr('transform', 'translate(0, ' + yOffset + ')')\n    .call(ideo.brush)\n    .call(ideo.brush.move, [x0, x1]);\n}\n\nfunction setSelectedRegion(from, to, ideo) {\n  // Genomics web UIs are 1-based, fully closed.\n  // I.e. If start = 20 bp and stop = 10 bp, then extent = 11 bp.\n  // Details:\n  // http://genome.ucsc.edu/blog/the-ucsc-genome-browser-coordinate-counting-systems/\n  // https://www.biostars.org/p/84686/\n  var extent = to - from + 1;\n  ideo.selectedRegion = {from: from, to: to, extent: extent};\n}\n\n/**\n * Creates a sliding window along a chromosome\n *\n * @param chr Chromosome name (e.g. 1) or range, e.g. chr1:104325484-119977655\n * @param from Genomic start coordinate in base pairs, e.g. 104325484\n * @param to Genomic end coordinate in base pairs, e.g. 119977655\n */\nfunction createBrush(chr, from, to) {\n  var chrModel, chrLengthBp, bpDomain, pxRange, lastBand,\n    ideo = this,\n    width = ideo.config.chrWidth + 6.5,\n    xOffset = ideo._layout.margin.left;\n\n  [chr, from, to] = refineGenomicCoordinates(chr, from, to);\n\n  chrModel = getChrModel(chr, ideo);\n\n  [bpDomain, pxRange] = getBasePairDomainAndPixelRange(chrModel, xOffset);\n\n  lastBand = chrModel.bands.slice(-1)[0];\n  chrLengthBp = lastBand.bp.stop;\n\n  if (typeof from === 'undefined') from = Math.floor(chrLengthBp / 10);\n  if (typeof to === 'undefined') to = Math.ceil(from * 2);\n\n  setBrush(bpDomain, pxRange, xOffset, width, ideo);\n\n  setSelectedRegion(from, to, ideo);\n  writeBrush(chrModel, from, to, xOffset, width, ideo);\n}\n\nexport {onBrushMove, onBrushEnd, createBrush};\n","/**\n * @fileoverview Allows a click event handler to be attached to the ideogram\n *\n * This works similar to the \"brush\" which allows a region to be selected.\n * The click handler does not allow a region, but a precise location.\n *\n */\n\nimport {d3} from './lib';\n\n/**\n * Custom event handler, fired upon clicks on the chromosome (to change\n * position)\n */\nfunction onCursorMove() {\n  call(this.onCursorMoveCallback);\n}\n\nfunction setCursor(position, bpDomain, pxRange, xOffset, width, ideo) {\n  var xScale;\n\n  xScale = d3.scaleLinear().domain(bpDomain).range(pxRange);\n\n  if (!('rotatable' in ideo.config && ideo.config.rotatable === false)) {\n    console.warn('Using the cursor with rotate is not supported.');\n  }\n\n  var yTranslate = ideo._layout.getChromosomeSetYTranslate(0);\n  var yOffset = yTranslate + (ideo.config.chrWidth - width) / 2;\n\n  // TODO: check if newPosition is valid value (in range)\n\n  var cursorBrush = d3.select(ideo.selector).append('g')\n    .attr('class', 'brush')\n    .attr('transform', 'translate(0, ' + yOffset + ')')\n    .append('rect')\n    .attr('class', 'cursor')\n    .attr('x', xScale(position))\n    .attr('y', 0)\n    .attr('width', 1) // this could be a configuration param\n    .attr('height', 30); // MAGIC NUMBER! need help with this one\n\n  // call the callback for the first time (onLoad)\n  if (ideo.onCursorMove) {\n    ideo.onCursorMoveCallback(position);\n  }\n\n  if (!ideo.setCursorPosition) {\n    ideo.setCursorPosition = function(newPosition) {\n      // TODO: check if newPosition is valid value (in range)\n      cursorBrush.attr('x', xScale(newPosition));\n      if (ideo.onCursorMove) {\n        ideo.onCursorMoveCallback(newPosition);\n      }\n    };\n  }\n\n  d3.selectAll(ideo.selector + ' .chromosome').on('click', function(event) {\n    var x = event.offsetX; // minimum value seems to be 25\n\n    // adjust for screen (6 is a magic number that seems to work)\n    x -=6;\n\n    // move the cursor\n    cursorBrush.attr('x', x);\n\n    // calculate the new position and perform callback\n    var newPosition = Math.floor(xScale.invert(x));\n    if (ideo.onCursorMove) {\n      ideo.onCursorMoveCallback(newPosition);\n    }\n  });\n}\n\nfunction getBasePairDomainAndPixelRange(chrModel, xOffset) {\n  var band, i,\n    bpDomain = [1],\n    pxRange = [1],\n    lastBand = chrModel.bands.slice(-1)[0];\n\n  for (i = 0; i < chrModel.bands.length; i++) {\n    band = chrModel.bands[i];\n    bpDomain.push(band.bp.start);\n    pxRange.push(band.px.start + xOffset);\n  }\n\n  bpDomain.push(lastBand.bp.stop - 1);\n  pxRange.push(lastBand.px.stop + xOffset);\n\n  return [bpDomain, pxRange];\n}\n\nfunction getChrModel(chr, ideo) {\n  var i, cm, chrModel;\n\n  for (i = 0; i < ideo.chromosomesArray.length; i++) {\n    cm = ideo.chromosomesArray[i];\n    if (cm.name === chr) {\n      chrModel = cm;\n      return chrModel;\n    }\n  }\n}\n\n/**\n * Creates a clickable cursor along a chromosome.\n *\n * @param position Genomic start coordinate in base pairs, e.g. 104325484\n */\nfunction createClickCursor(position) {\n  var chrModel, bpDomain,\n    pxRange,\n    ideo = this,\n    width = ideo.config.chrWidth + 6.5, // 6.5 magic number?\n    xOffset = ideo._layout.margin.left;\n\n  if (typeof position === 'undefined') {\n    return false;\n  }\n\n  chrModel = getChrModel(ideo.config.chromosome, ideo);\n  [bpDomain, pxRange] = getBasePairDomainAndPixelRange(chrModel, xOffset);\n\n  // call setCursor to complete the job.\n  setCursor(position, bpDomain, pxRange, xOffset, width, ideo);\n}\n\nexport {onCursorMove, createClickCursor};\n","/**\n * @fileoverview Instance methods for sex chromosomes (allosomes).\n *\n * This module provides methods for drawing karyotypically normal\n * male and female mammalian genomes.\n */\n\n/**\n * Appends SVG elements depicting sex chromosomes to the document.\n */\nfunction drawSexChromosomes(container, chrIndex) {\n  var bandsArray, taxid, chrs,\n    sexChromosomeIndexes, sciLength,\n    chromosome, bands, chrModel, sci, homologIndex;\n\n  bandsArray = this.bandsArray;\n  taxid = this.config.taxid;\n  chrs = this.config.chromosomes[taxid];\n\n  if (this.config.sex === 'male') {\n    sexChromosomeIndexes = [1, 0];\n  } else {\n    sexChromosomeIndexes = [0, 0];\n  }\n\n  sciLength = sexChromosomeIndexes.length;\n\n  for (homologIndex = 0; homologIndex < sciLength; homologIndex++) {\n    sci = sexChromosomeIndexes[homologIndex] + chrIndex;\n    chromosome = chrs[sci];\n    bands = bandsArray[taxid][sci];\n    chrModel = this.getChromosomeModel(bands, chromosome, taxid, sci);\n    this.appendHomolog(chrModel, chrIndex, homologIndex, container);\n  }\n}\n\n/**\n * Sets instance properties regarding sex chromosomes.\n * Currently only supported for mammals.\n * TODO: Support all sexually reproducing taxa\n *   XY sex-determination (mammals):\n *     - Male: XY <- heterogametic\n *     - Female: XX\n *   ZW sex-determination (birds):\n *     - Male: ZZ\n *     - Female: ZW <- heterogametic\n *   X0 sex-determination (some insects):\n *     - Male: X0, i.e. only X <- heterogametic?\n *     - Female: XX\n * TODO: Support sex chromosome aneuploidies in mammals\n *     - Turner syndrome: X0\n *     - Klinefelter syndome: XXY\n *  More types:\n *  https://en.wikipedia.org/wiki/Category:Sex_chromosome_aneuploidies\n */\nfunction setSexChromosomes(chrs) {\n  var chr, i,\n    ideo = this,\n    sexChrs = {X: 1, Y: 1};\n\n  if (this.config.ploidy !== 2 || !this.config.sex) return;\n\n  ideo.sexChromosomes.list = [];\n\n  for (i = 0; i < chrs.length; i++) {\n    chr = chrs[i];\n    if (ideo.config.sex === 'male' && chr in sexChrs) {\n      ideo.sexChromosomes.list.push(chr);\n      if (!ideo.sexChromosomes.index) {\n        ideo.sexChromosomes.index = i;\n      }\n    } else if (chr === 'X') {\n      ideo.sexChromosomes.list.push(chr, chr);\n      ideo.sexChromosomes.index = i;\n    }\n  }\n}\n\nexport {drawSexChromosomes, setSexChromosomes};\n","/**\n * @fileoverview Methods to convert to and from different types of coordinates.\n *\n * Ideogram.js uses multiple coordinate systems, e.g. base pairs (bp) and\n * pixels (px).  These methods interconvert between those coordinate systems.\n *\n * TODO:\n * - Add methods to interconvert between ISCN coordinates and base pairs,\n * pixels.\n */\n\nfunction throwBpToPxError(bp, chr, band) {\n  throw new Error(\n    'Base pair out of range.  ' +\n    'bp: ' + bp + '; length of chr' + chr.name + ': ' + band.bp.stop\n  );\n}\n\nfunction getPx(chr, bp) {\n  var i, px, band, bpToIscnScale, iscn, iscnStart, iscnStop, iscnLength,\n    bpStart, bpStop, bpLength, pxStart, pxLength;\n\n  for (i = 0; i < chr.bands.length; i++) {\n    band = chr.bands[i];\n    bpStart = band.bp.start;\n    bpStop = band.bp.stop;\n    bpLength = bpStop - bpStart;\n    iscnStart = band.iscn.start;\n    iscnStop = band.iscn.stop;\n    iscnLength = iscnStop - iscnStart;\n    pxStart = band.px.start;\n    pxLength = band.px.width;\n\n    if (bp >= bpStart && bp <= bpStop) {\n      bpToIscnScale = iscnLength / bpLength;\n      iscn = iscnStart + (bp - bpStart) * bpToIscnScale;\n      px = pxStart + (pxLength * (iscn - iscnStart) / (iscnLength));\n\n      return [px, band];\n    }\n  }\n  return [null, band];\n}\n\n/**\n * Converts base pair coordinates to pixel offsets.\n * Bp-to-pixel scales differ among cytogenetic bands.\n *\n * For example, if we want to depict a gene on a chromosome, then we need\n * to convert the gene's location in base pairs to a location in pixels offset\n * from the start of the chromosome.\n */\nfunction convertBpToPx(chr, bp) {\n  var band, px;\n\n  if (chr.bands.length > 1 || chr.name === 'MT') {\n    [px, band] = getPx(chr, bp);\n    if (px !== null) return px;\n  } else if (bp >= 1 && bp <= chr.length) {\n    px = chr.scale.bp * bp;\n    return px;\n  }\n\n  throwBpToPxError(bp, chr, band);\n}\n\nfunction throwPxToBpError(px, chr, pxStop) {\n  throw new Error(\n    'Pixel out of range.  ' +\n    'px: ' + px + '; length of chr' + chr.name + ': ' + pxStop\n  );\n}\n\nfunction getBp(iscnStop, iscnStart, px, pxStop, pxStart, band, iscnLength) {\n  var pxLength, bpLength, pxToIscnScale, iscn, bp;\n\n  iscnLength = iscnStop - iscnStart;\n  pxLength = pxStop - pxStart;\n  bpLength = band.bp.stop - band.bp.start;\n\n  pxToIscnScale = iscnLength / pxLength;\n  iscn = iscnStart + (px - pxStart) * pxToIscnScale;\n\n  bp = band.bp.start + (bpLength * (iscn - iscnStart) / iscnLength);\n\n  return Math.round(bp);\n}\n\n/**\n * Converts pixel offsets to base pair coordinates.\n * Pixel-to-bp scales differ among cytogenetic bands.\n *\n * For example, if we want to determine the genomic location a user clicked on\n * (e.g. when creating a brush / sliding window region), then we need to\n * convert pixels to base pairs.\n */\nfunction convertPxToBp(chr, px) {\n  var i, band, bp, pxStart, pxStop, iscnStart, iscnStop, iscnLength;\n\n  if (px === 0) {\n    px = chr.bands[0].px.start;\n  }\n\n  for (i = 0; i < chr.bands.length; i++) {\n    band = chr.bands[i];\n\n    pxStart = band.px.start;\n    pxStop = band.px.stop;\n    iscnStart = band.iscn.start;\n    iscnStop = band.iscn.stop;\n\n    if (px >= pxStart && px <= pxStop) {\n      bp = getBp(iscnStop, iscnStart, px, pxStop, pxStart, band, iscnLength);\n      return bp;\n    }\n  }\n  throwPxToBpError(px, chr, pxStop);\n}\n\nexport {convertBpToPx, convertPxToBp};\n","let array8 = arrayUntyped,\n    array16 = arrayUntyped,\n    array32 = arrayUntyped,\n    arrayLengthen = arrayLengthenUntyped,\n    arrayWiden = arrayWidenUntyped;\nif (typeof Uint8Array !== \"undefined\") {\n  array8 = function(n) { return new Uint8Array(n); };\n  array16 = function(n) { return new Uint16Array(n); };\n  array32 = function(n) { return new Uint32Array(n); };\n\n  arrayLengthen = function(array, length) {\n    if (array.length >= length) return array;\n    var copy = new array.constructor(length);\n    copy.set(array);\n    return copy;\n  };\n\n  arrayWiden = function(array, width) {\n    var copy;\n    switch (width) {\n      case 16: copy = array16(array.length); break;\n      case 32: copy = array32(array.length); break;\n      default: throw new Error(\"invalid array width!\");\n    }\n    copy.set(array);\n    return copy;\n  };\n}\n\nfunction arrayUntyped(n) {\n  var array = new Array(n), i = -1;\n  while (++i < n) array[i] = 0;\n  return array;\n}\n\nfunction arrayLengthenUntyped(array, length) {\n  var n = array.length;\n  while (n < length) array[n++] = 0;\n  return array;\n}\n\nfunction arrayWidenUntyped(array, width) {\n  if (width > 32) throw new Error(\"invalid array width!\");\n  return array;\n}\n\n// An arbitrarily-wide array of bitmasks\nfunction bitarray(n) {\n  this.length = n;\n  this.subarrays = 1;\n  this.width = 8;\n  this.masks = {\n    0: 0\n  }\n\n  this[0] = array8(n);\n}\n\nbitarray.prototype.lengthen = function(n) {\n  var i, len;\n  for (i = 0, len = this.subarrays; i < len; ++i) {\n    this[i] = arrayLengthen(this[i], n);\n  }\n  this.length = n;\n};\n\n// Reserve a new bit index in the array, returns {offset, one}\nbitarray.prototype.add = function() {\n  var m, w, one, i, len;\n\n  for (i = 0, len = this.subarrays; i < len; ++i) {\n    m = this.masks[i];\n    w = this.width - (32 * i);\n    // isolate the rightmost zero bit and return it as an unsigned int of 32 bits, if NaN or -1, return a 0 \n    one = (~m & (m + 1)) >>> 0;\n\n    if (w >= 32 && !one) {\n      continue;\n    }\n\n    if (w < 32 && (one & (1 << w))) {\n      // widen this subarray\n      this[i] = arrayWiden(this[i], w <<= 1);\n      this.width = 32 * i + w;\n    }\n\n    this.masks[i] |= one;\n\n    return {\n      offset: i,\n      one: one\n    };\n  }\n\n  // add a new subarray\n  this[this.subarrays] = array8(this.length);\n  this.masks[this.subarrays] = 1;\n  this.width += 8;\n  return {\n    offset: this.subarrays++,\n    one: 1\n  };\n};\n\n// Copy record from index src to index dest\nbitarray.prototype.copy = function(dest, src) {\n  var i, len;\n  for (i = 0, len = this.subarrays; i < len; ++i) {\n    this[i][dest] = this[i][src];\n  }\n};\n\n// Truncate the array to the given length\nbitarray.prototype.truncate = function(n) {\n  var i, len;\n  for (i = 0, len = this.subarrays; i < len; ++i) {\n    for (var j = this.length - 1; j >= n; j--) {\n      this[i][j] = 0;\n    }\n  }\n  this.length = n;\n};\n\n// Checks that all bits for the given index are 0\nbitarray.prototype.zero = function(n) {\n  var i, len;\n  for (i = 0, len = this.subarrays; i < len; ++i) {\n    if (this[i][n]) {\n      return false;\n    }\n  }\n  return true;\n};\n\n// Checks that all bits for the given index are 0 except for possibly one\nbitarray.prototype.zeroExcept = function(n, offset, zero) {\n  var i, len;\n  for (i = 0, len = this.subarrays; i < len; ++i) {\n    if (i === offset ? this[i][n] & zero : this[i][n]) {\n      return false;\n    }\n  }\n  return true;\n};\n\n// Checks that all bits for the given index are 0 except for the specified mask.\n// The mask should be an array of the same size as the filter subarrays width.\nbitarray.prototype.zeroExceptMask = function(n, mask) {\n  var i, len;\n  for (i = 0, len = this.subarrays; i < len; ++i) {\n    if (this[i][n] & mask[i]) {\n      return false;\n    }\n  }\n  return true;\n}\n\n// Checks that only the specified bit is set for the given index\nbitarray.prototype.only = function(n, offset, one) {\n  var i, len;\n  for (i = 0, len = this.subarrays; i < len; ++i) {\n    if (this[i][n] != (i === offset ? one : 0)) {\n      return false;\n    }\n  }\n  return true;\n};\n\n// Checks that only the specified bit is set for the given index except for possibly one other\nbitarray.prototype.onlyExcept = function(n, offset, zero, onlyOffset, onlyOne) {\n  var mask;\n  var i, len;\n  for (i = 0, len = this.subarrays; i < len; ++i) {\n    mask = this[i][n];\n    if (i === offset)\n      mask &= zero;\n    if (mask != (i === onlyOffset ? onlyOne : 0)) {\n      return false;\n    }\n  }\n  return true;\n};\n\nexport default {\n  array8: arrayUntyped,\n  array16: arrayUntyped,\n  array32: arrayUntyped,\n  arrayLengthen: arrayLengthenUntyped,\n  arrayWiden: arrayWidenUntyped,\n  bitarray: bitarray\n};\n","const filterExact = (bisect, value) => {\n  return function(values) {\n    var n = values.length;\n    return [bisect.left(values, value, 0, n), bisect.right(values, value, 0, n)];\n  };\n}\n\nconst filterRange = (bisect, range) => {\n  var min = range[0],\n      max = range[1];\n  return function(values) {\n    var n = values.length;\n    return [bisect.left(values, min, 0, n), bisect.left(values, max, 0, n)];\n  };\n}\n\nconst filterAll = values => {\n  return [0, values.length];\n}\n\nexport default {\n  filterExact,\n  filterRange,\n  filterAll\n};\n","export default d => {\n  return d;\n};\n","export default () =>  {\n  return null;\n}\n","export default () => {\n  return 0;\n}\n","import identity from './identity';\n\nfunction heap_by(f) {\n\n  // Builds a binary heap within the specified array a[lo:hi]. The heap has the\n  // property such that the parent a[lo+i] is always less than or equal to its\n  // two children: a[lo+2*i+1] and a[lo+2*i+2].\n  function heap(a, lo, hi) {\n    var n = hi - lo,\n        i = (n >>> 1) + 1;\n    while (--i > 0) sift(a, i, n, lo);\n    return a;\n  }\n\n  // Sorts the specified array a[lo:hi] in descending order, assuming it is\n  // already a heap.\n  function sort(a, lo, hi) {\n    var n = hi - lo,\n        t;\n    while (--n > 0) t = a[lo], a[lo] = a[lo + n], a[lo + n] = t, sift(a, 1, n, lo);\n    return a;\n  }\n\n  // Sifts the element a[lo+i-1] down the heap, where the heap is the contiguous\n  // slice of array a[lo:lo+n]. This method can also be used to update the heap\n  // incrementally, without incurring the full cost of reconstructing the heap.\n  function sift(a, i, n, lo) {\n    var d = a[--lo + i],\n        x = f(d),\n        child;\n    while ((child = i << 1) <= n) {\n      if (child < n && f(a[lo + child]) > f(a[lo + child + 1])) child++;\n      if (x <= f(a[lo + child])) break;\n      a[lo + i] = a[lo + child];\n      i = child;\n    }\n    a[lo + i] = d;\n  }\n\n  heap.sort = sort;\n  return heap;\n}\n\nconst h = heap_by(identity);\nh.by = heap_by;\n\nexport default h;\n","import identity from './identity';\nimport xFilterHeap from './heap';\n\nfunction heapselect_by(f) {\n  var heap = xFilterHeap.by(f);\n\n  // Returns a new array containing the top k elements in the array a[lo:hi].\n  // The returned array is not sorted, but maintains the heap property. If k is\n  // greater than hi - lo, then fewer than k elements will be returned. The\n  // order of elements in a is unchanged by this operation.\n  function heapselect(a, lo, hi, k) {\n    var queue = new Array(k = Math.min(hi - lo, k)),\n        min,\n        i,\n        d;\n\n    for (i = 0; i < k; ++i) queue[i] = a[lo++];\n    heap(queue, 0, k);\n\n    if (lo < hi) {\n      min = f(queue[0]);\n      do {\n        if (f(d = a[lo]) > min) {\n          queue[0] = d;\n          min = f(heap(queue, 0, k)[0]);\n        }\n      } while (++lo < hi);\n    }\n\n    return queue;\n  }\n\n  return heapselect;\n}\n\n\nconst h = heapselect_by(identity);\nh.by = heapselect_by; // assign the raw function to the export as well\n\nexport default h;\n","import identity from './identity';\n\nfunction bisect_by(f) {\n\n  // Locate the insertion point for x in a to maintain sorted order. The\n  // arguments lo and hi may be used to specify a subset of the array which\n  // should be considered; by default the entire array is used. If x is already\n  // present in a, the insertion point will be before (to the left of) any\n  // existing entries. The return value is suitable for use as the first\n  // argument to `array.splice` assuming that a is already sorted.\n  //\n  // The returned insertion point i partitions the array a into two halves so\n  // that all v < x for v in a[lo:i] for the left side and all v >= x for v in\n  // a[i:hi] for the right side.\n  function bisectLeft(a, x, lo, hi) {\n    while (lo < hi) {\n      var mid = lo + hi >>> 1;\n      if (f(a[mid]) < x) lo = mid + 1;\n      else hi = mid;\n    }\n    return lo;\n  }\n\n  // Similar to bisectLeft, but returns an insertion point which comes after (to\n  // the right of) any existing entries of x in a.\n  //\n  // The returned insertion point i partitions the array into two halves so that\n  // all v <= x for v in a[lo:i] for the left side and all v > x for v in\n  // a[i:hi] for the right side.\n  function bisectRight(a, x, lo, hi) {\n    while (lo < hi) {\n      var mid = lo + hi >>> 1;\n      if (x < f(a[mid])) hi = mid;\n      else lo = mid + 1;\n    }\n    return lo;\n  }\n\n  bisectRight.right = bisectRight;\n  bisectRight.left = bisectLeft;\n  return bisectRight;\n}\n\nconst bisect = bisect_by(identity);\nbisect.by = bisect_by; // assign the raw function to the export as well\n\nexport default bisect;\n\n","export default (array, index, deep) => {\n  for (var i = 0, n = index.length, copy = deep ? JSON.parse(JSON.stringify(array)) : new Array(n); i < n; ++i) {\n    copy[i] = array[index[i]];\n  }\n  return copy;\n}\n","const reduceIncrement = p => {\n  return p + 1;\n}\n\nconst reduceDecrement = p => {\n  return p - 1;\n}\n\nconst reduceAdd = f => {\n  return function(p, v) {\n    return p + +f(v);\n  };\n}\n\nconst reduceSubtract = f => {\n  return function(p, v) {\n    return p - f(v);\n  };\n}\n\nexport default {\n  reduceIncrement,\n  reduceDecrement,\n  reduceAdd,\n  reduceSubtract\n};\n","import deep from \"@ranfdev/deepobj\"\n// Note(cg): result was previsouly using lodash.result, not ESM compatible.\n \nconst get = (obj, prop) => {\n  const value = obj[prop];\n  return (typeof value === 'function') ? value.call(obj) : value;\n}\n\n/**\n * get value of object at a deep path.\n * if the resolved value is a function,\n * it's invoked with the `this` binding of \n * its parent object and its result is returned. \n *  \n * @param  {Object} obj  the object (e.g. { 'a': [{ 'b': { 'c1': 3, 'c2': 4} }], 'd': {e:1} }; )\n * @param  {String} path deep path (e.g. `d.e`` or `a[0].b.c1`. Dot notation (a.0.b)is also supported)\n * @return {Any}      the resolved value\n */\nconst reg = /\\[([\\w\\d]+)\\]/g;\nexport default (obj, path) => {\n  return deep(get, obj, path.replace(reg, '.$1'))\n}\n","export default function(t,e,i,n,r){for(r in n=(i=i.split(\".\")).splice(-1,1),i)e=e[i[r]]=e[i[r]]||{};return t(e,n)};\n//# sourceMappingURL=deepobj.m.js.map\n","import xfilterArray from './array';\nimport xfilterFilter from './filter';\nimport cr_identity from './identity';\nimport cr_null from './null';\nimport cr_zero from './zero';\nimport xfilterHeapselect from './heapselect';\nimport xfilterHeap from './heap';\nimport bisect from './bisect';\nimport permute from './permute';\nimport xfilterReduce from './reduce';\nimport result from './result';\n\n// constants\nvar REMOVED_INDEX = -1;\n\ncrossfilter.heap = xfilterHeap;\ncrossfilter.heapselect = xfilterHeapselect;\ncrossfilter.bisect = bisect;\ncrossfilter.permute = permute;\nexport default crossfilter;\n\nfunction crossfilter() {\n  var crossfilter = {\n    add: add,\n    remove: removeData,\n    dimension: dimension,\n    groupAll: groupAll,\n    size: size,\n    all: all,\n    allFiltered: allFiltered,\n    onChange: onChange,\n    isElementFiltered: isElementFiltered\n  };\n\n  var data = [], // the records\n      n = 0, // the number of records; data.length\n      filters, // 1 is filtered out\n      filterListeners = [], // when the filters change\n      dataListeners = [], // when data is added\n      removeDataListeners = [], // when data is removed\n      callbacks = [];\n\n  filters = new xfilterArray.bitarray(0);\n\n  // Adds the specified new records to this crossfilter.\n  function add(newData) {\n    var n0 = n,\n        n1 = newData.length;\n\n    // If there's actually new data to add…\n    // Merge the new data into the existing data.\n    // Lengthen the filter bitset to handle the new records.\n    // Notify listeners (dimensions and groups) that new data is available.\n    if (n1) {\n      data = data.concat(newData);\n      filters.lengthen(n += n1);\n      dataListeners.forEach(function(l) { l(newData, n0, n1); });\n      triggerOnChange('dataAdded');\n    }\n\n    return crossfilter;\n  }\n\n  // Removes all records that match the current filters, or if a predicate function is passed,\n  // removes all records matching the predicate (ignoring filters).\n  function removeData(predicate) {\n    var // Mapping from old record indexes to new indexes (after records removed)\n        newIndex = new Array(n),\n        removed = [],\n        usePred = typeof predicate === 'function',\n        shouldRemove = function (i) {\n          return usePred ? predicate(data[i], i) : filters.zero(i)\n        };\n\n    for (var index1 = 0, index2 = 0; index1 < n; ++index1) {\n      if ( shouldRemove(index1) ) {\n        removed.push(index1);\n        newIndex[index1] = REMOVED_INDEX;\n      } else {\n        newIndex[index1] = index2++;\n      }\n    }\n\n    // Remove all matching records from groups.\n    filterListeners.forEach(function(l) { l(-1, -1, [], removed, true); });\n\n    // Update indexes.\n    removeDataListeners.forEach(function(l) { l(newIndex); });\n\n    // Remove old filters and data by overwriting.\n    for (var index3 = 0, index4 = 0; index3 < n; ++index3) {\n      if ( newIndex[index3] !== REMOVED_INDEX ) {\n        if (index3 !== index4) filters.copy(index4, index3), data[index4] = data[index3];\n        ++index4;\n      }\n    }\n\n    data.length = n = index4;\n    filters.truncate(index4);\n    triggerOnChange('dataRemoved');\n  }\n\n  function maskForDimensions(dimensions) {\n    var n,\n        d,\n        len,\n        id,\n        mask = Array(filters.subarrays);\n    for (n = 0; n < filters.subarrays; n++) { mask[n] = ~0; }\n    for (d = 0, len = dimensions.length; d < len; d++) {\n      // The top bits of the ID are the subarray offset and the lower bits are the bit\n      // offset of the \"one\" mask.\n      id = dimensions[d].id();\n      mask[id >> 7] &= ~(0x1 << (id & 0x3f));\n    }\n    return mask;\n  }\n\n  // Return true if the data element at index i is filtered IN.\n  // Optionally, ignore the filters of any dimensions in the ignore_dimensions list.\n  function isElementFiltered(i, ignore_dimensions) {\n    var mask = maskForDimensions(ignore_dimensions || []);\n    return filters.zeroExceptMask(i,mask);\n  }\n\n  // Adds a new dimension with the specified value accessor function.\n  function dimension(value, iterable) {\n\n    if (typeof value === 'string') {\n      var accessorPath = value;\n      value = function(d) { return result(d, accessorPath); };\n    }\n\n    var dimension = {\n      filter: filter,\n      filterExact: filterExact,\n      filterRange: filterRange,\n      filterFunction: filterFunction,\n      filterAll: filterAll,\n      currentFilter: currentFilter,\n      hasCurrentFilter: hasCurrentFilter,\n      top: top,\n      bottom: bottom,\n      group: group,\n      groupAll: groupAll,\n      dispose: dispose,\n      remove: dispose, // for backwards-compatibility\n      accessor: value,\n      id: function() { return id; }\n    };\n\n    var one, // lowest unset bit as mask, e.g., 00001000\n        zero, // inverted one, e.g., 11110111\n        offset, // offset into the filters arrays\n        id, // unique ID for this dimension (reused when dimensions are disposed)\n        values, // sorted, cached array\n        index, // maps sorted value index -> record index (in data)\n        newValues, // temporary array storing newly-added values\n        newIndex, // temporary array storing newly-added index\n        iterablesIndexCount,\n        iterablesIndexFilterStatus,\n        iterablesEmptyRows = [],\n        sortRange = function(n) {\n          return cr_range(n).sort(function(A, B) {\n            var a = newValues[A], b = newValues[B];\n            return a < b ? -1 : a > b ? 1 : A - B;\n          });\n        },\n        refilter = xfilterFilter.filterAll, // for recomputing filter\n        refilterFunction, // the custom filter function in use\n        filterValue, // the value used for filtering (value, array, function or undefined)\n        filterValuePresent, // true if filterValue contains something\n        indexListeners = [], // when data is added\n        dimensionGroups = [],\n        lo0 = 0,\n        hi0 = 0,\n        t = 0,\n        k;\n\n    // Updating a dimension is a two-stage process. First, we must update the\n    // associated filters for the newly-added records. Once all dimensions have\n    // updated their filters, the groups are notified to update.\n    dataListeners.unshift(preAdd);\n    dataListeners.push(postAdd);\n\n    removeDataListeners.push(removeData);\n\n    // Add a new dimension in the filter bitmap and store the offset and bitmask.\n    var tmp = filters.add();\n    offset = tmp.offset;\n    one = tmp.one;\n    zero = ~one;\n\n    // Create a unique ID for the dimension\n    // IDs will be re-used if dimensions are disposed.\n    // For internal use the ID is the subarray offset shifted left 7 bits or'd with the\n    // bit offset of the set bit in the dimension's \"one\" mask.\n    id = (offset << 7) | (Math.log(one) / Math.log(2));\n\n    preAdd(data, 0, n);\n    postAdd(data, 0, n);\n\n    // Incorporates the specified new records into this dimension.\n    // This function is responsible for updating filters, values, and index.\n    function preAdd(newData, n0, n1) {\n      var newIterablesIndexCount,\n          newIterablesIndexFilterStatus;\n\n      if (iterable){\n        // Count all the values\n        t = 0;\n        j = 0;\n        k = [];\n\n        for (var i0 = 0; i0 < newData.length; i0++) {\n          for(j = 0, k = value(newData[i0]); j < k.length; j++) {\n            t++;\n          }\n        }\n\n        newValues = [];\n        newIterablesIndexCount = cr_range(newData.length);\n        newIterablesIndexFilterStatus = cr_index(t,1);\n        var unsortedIndex = cr_range(t);\n\n        for (var l = 0, index1 = 0; index1 < newData.length; index1++) {\n          k = value(newData[index1])\n          //\n          if(!k.length){\n            newIterablesIndexCount[index1] = 0;\n            iterablesEmptyRows.push(index1 + n0);\n            continue;\n          }\n          newIterablesIndexCount[index1] = k.length\n          for (j = 0; j < k.length; j++) {\n            newValues.push(k[j]);\n            unsortedIndex[l] = index1;\n            l++;\n          }\n        }\n\n        // Create the Sort map used to sort both the values and the valueToData indices\n        var sortMap = sortRange(t);\n\n        // Use the sortMap to sort the newValues\n        newValues = permute(newValues, sortMap);\n\n\n        // Use the sortMap to sort the unsortedIndex map\n        // newIndex should be a map of sortedValue -> crossfilterData\n        newIndex = permute(unsortedIndex, sortMap)\n\n      } else{\n        // Permute new values into natural order using a standard sorted index.\n        newValues = newData.map(value);\n        newIndex = sortRange(n1);\n        newValues = permute(newValues, newIndex);\n      }\n\n      // Bisect newValues to determine which new records are selected.\n      var bounds = refilter(newValues), lo1 = bounds[0], hi1 = bounds[1];\n\n      var index2, index3, index4;\n      if(iterable) {\n        n1 = t;\n        if (refilterFunction) {\n          for (index2 = 0; index2 < n1; ++index2) {\n            if (!refilterFunction(newValues[index2], index2)) {\n              if(--newIterablesIndexCount[newIndex[index2]] === 0) {\n                filters[offset][newIndex[index2] + n0] |= one;\n              }\n              newIterablesIndexFilterStatus[index2] = 1;\n            }\n          }\n        } else {\n          for (index3 = 0; index3 < lo1; ++index3) {\n            if(--newIterablesIndexCount[newIndex[index3]] === 0) {\n              filters[offset][newIndex[index3] + n0] |= one;\n            }\n            newIterablesIndexFilterStatus[index3] = 1;\n          }\n          for (index4 = hi1; index4 < n1; ++index4) {\n            if(--newIterablesIndexCount[newIndex[index4]] === 0) {\n              filters[offset][newIndex[index4] + n0] |= one;\n            }\n            newIterablesIndexFilterStatus[index4] = 1;\n          }\n        }\n      } else {\n        if (refilterFunction) {\n          for (index2 = 0; index2 < n1; ++index2) {\n            if (!refilterFunction(newValues[index2], index2)) {\n              filters[offset][newIndex[index2] + n0] |= one;\n            }\n          }\n        } else {\n          for (index3 = 0; index3 < lo1; ++index3) {\n            filters[offset][newIndex[index3] + n0] |= one;\n          }\n          for (index4 = hi1; index4 < n1; ++index4) {\n            filters[offset][newIndex[index4] + n0] |= one;\n          }\n        }\n      }\n\n      // If this dimension previously had no data, then we don't need to do the\n      // more expensive merge operation; use the new values and index as-is.\n      if (!n0) {\n        values = newValues;\n        index = newIndex;\n        iterablesIndexCount = newIterablesIndexCount;\n        iterablesIndexFilterStatus = newIterablesIndexFilterStatus;\n        lo0 = lo1;\n        hi0 = hi1;\n        return;\n      }\n\n\n\n      var oldValues = values,\n        oldIndex = index,\n        oldIterablesIndexFilterStatus = iterablesIndexFilterStatus,\n        old_n0,\n        i1 = 0;\n\n      i0 = 0;\n\n      if(iterable){\n        old_n0 = n0\n        n0 = oldValues.length;\n        n1 = t\n      }\n\n      // Otherwise, create new arrays into which to merge new and old.\n      values = iterable ? new Array(n0 + n1) : new Array(n);\n      index = iterable ? new Array(n0 + n1) : cr_index(n, n);\n      if(iterable) iterablesIndexFilterStatus = cr_index(n0 + n1, 1);\n\n      // Concatenate the newIterablesIndexCount onto the old one.\n      if(iterable) {\n        var oldiiclength = iterablesIndexCount.length;\n        iterablesIndexCount = xfilterArray.arrayLengthen(iterablesIndexCount, n);\n        for(var j=0; j+oldiiclength < n; j++) {\n          iterablesIndexCount[j+oldiiclength] = newIterablesIndexCount[j];\n        }\n      }\n\n      // Merge the old and new sorted values, and old and new index.\n      var index5 = 0;\n      for (; i0 < n0 && i1 < n1; ++index5) {\n        if (oldValues[i0] < newValues[i1]) {\n          values[index5] = oldValues[i0];\n          if(iterable) iterablesIndexFilterStatus[index5] = oldIterablesIndexFilterStatus[i0];\n          index[index5] = oldIndex[i0++];\n        } else {\n          values[index5] = newValues[i1];\n          if(iterable) iterablesIndexFilterStatus[index5] = newIterablesIndexFilterStatus[i1];\n          index[index5] = newIndex[i1++] + (iterable ? old_n0 : n0);\n        }\n      }\n\n      // Add any remaining old values.\n      for (; i0 < n0; ++i0, ++index5) {\n        values[index5] = oldValues[i0];\n        if(iterable) iterablesIndexFilterStatus[index5] = oldIterablesIndexFilterStatus[i0];\n        index[index5] = oldIndex[i0];\n      }\n\n      // Add any remaining new values.\n      for (; i1 < n1; ++i1, ++index5) {\n        values[index5] = newValues[i1];\n        if(iterable) iterablesIndexFilterStatus[index5] = newIterablesIndexFilterStatus[i1];\n        index[index5] = newIndex[i1] + (iterable ? old_n0 : n0);\n      }\n\n      // Bisect again to recompute lo0 and hi0.\n      bounds = refilter(values), lo0 = bounds[0], hi0 = bounds[1];\n    }\n\n    // When all filters have updated, notify index listeners of the new values.\n    function postAdd(newData, n0, n1) {\n      indexListeners.forEach(function(l) { l(newValues, newIndex, n0, n1); });\n      newValues = newIndex = null;\n    }\n\n    function removeData(reIndex) {\n      if (iterable) {\n        for (var i0 = 0, i1 = 0; i0 < iterablesEmptyRows.length; i0++) {\n          if (reIndex[iterablesEmptyRows[i0]] !== REMOVED_INDEX) {\n            iterablesEmptyRows[i1] = reIndex[iterablesEmptyRows[i0]];\n            i1++;\n          }\n        }\n        iterablesEmptyRows.length = i1;\n        for (i0 = 0, i1 = 0; i0 < n; i0++) {\n          if (reIndex[i0] !== REMOVED_INDEX) {\n            if (i1 !== i0) iterablesIndexCount[i1] = iterablesIndexCount[i0];\n            i1++;\n          }\n        }\n        iterablesIndexCount = iterablesIndexCount.slice(0, i1);\n      }\n      // Rewrite our index, overwriting removed values\n      var n0 = values.length;\n      for (var i = 0, j = 0, oldDataIndex; i < n0; ++i) {\n        oldDataIndex = index[i];\n        if (reIndex[oldDataIndex] !== REMOVED_INDEX) {\n          if (i !== j) values[j] = values[i];\n          index[j] = reIndex[oldDataIndex];\n          if (iterable) {\n            iterablesIndexFilterStatus[j] = iterablesIndexFilterStatus[i];\n          }\n          ++j;\n        }\n      }\n      values.length = j;\n      if (iterable) iterablesIndexFilterStatus = iterablesIndexFilterStatus.slice(0, j);\n      while (j < n0) index[j++] = 0;\n\n      // Bisect again to recompute lo0 and hi0.\n      var bounds = refilter(values);\n      lo0 = bounds[0], hi0 = bounds[1];\n    }\n\n    // Updates the selected values based on the specified bounds [lo, hi].\n    // This implementation is used by all the public filter methods.\n    function filterIndexBounds(bounds) {\n\n      var lo1 = bounds[0],\n          hi1 = bounds[1];\n\n      if (refilterFunction) {\n        refilterFunction = null;\n        filterIndexFunction(function(d, i) { return lo1 <= i && i < hi1; }, bounds[0] === 0 && bounds[1] === values.length);\n        lo0 = lo1;\n        hi0 = hi1;\n        return dimension;\n      }\n\n      var i,\n          j,\n          k,\n          added = [],\n          removed = [],\n          valueIndexAdded = [],\n          valueIndexRemoved = [];\n\n\n      // Fast incremental update based on previous lo index.\n      if (lo1 < lo0) {\n        for (i = lo1, j = Math.min(lo0, hi1); i < j; ++i) {\n          added.push(index[i]);\n          valueIndexAdded.push(i);\n        }\n      } else if (lo1 > lo0) {\n        for (i = lo0, j = Math.min(lo1, hi0); i < j; ++i) {\n          removed.push(index[i]);\n          valueIndexRemoved.push(i);\n        }\n      }\n\n      // Fast incremental update based on previous hi index.\n      if (hi1 > hi0) {\n        for (i = Math.max(lo1, hi0), j = hi1; i < j; ++i) {\n          added.push(index[i]);\n          valueIndexAdded.push(i);\n        }\n      } else if (hi1 < hi0) {\n        for (i = Math.max(lo0, hi1), j = hi0; i < j; ++i) {\n          removed.push(index[i]);\n          valueIndexRemoved.push(i);\n        }\n      }\n\n      if(!iterable) {\n        // Flip filters normally.\n\n        for(i=0; i<added.length; i++) {\n          filters[offset][added[i]] ^= one;\n        }\n\n        for(i=0; i<removed.length; i++) {\n          filters[offset][removed[i]] ^= one;\n        }\n\n      } else {\n        // For iterables, we need to figure out if the row has been completely removed vs partially included\n        // Only count a row as added if it is not already being aggregated. Only count a row\n        // as removed if the last element being aggregated is removed.\n\n        var newAdded = [];\n        var newRemoved = [];\n        for (i = 0; i < added.length; i++) {\n          iterablesIndexCount[added[i]]++\n          iterablesIndexFilterStatus[valueIndexAdded[i]] = 0;\n          if(iterablesIndexCount[added[i]] === 1) {\n            filters[offset][added[i]] ^= one;\n            newAdded.push(added[i]);\n          }\n        }\n        for (i = 0; i < removed.length; i++) {\n          iterablesIndexCount[removed[i]]--\n          iterablesIndexFilterStatus[valueIndexRemoved[i]] = 1;\n          if(iterablesIndexCount[removed[i]] === 0) {\n            filters[offset][removed[i]] ^= one;\n            newRemoved.push(removed[i]);\n          }\n        }\n\n        added = newAdded;\n        removed = newRemoved;\n\n        // Now handle empty rows.\n        if(refilter === xfilterFilter.filterAll) {\n          for(i = 0; i < iterablesEmptyRows.length; i++) {\n            if((filters[offset][k = iterablesEmptyRows[i]] & one)) {\n              // Was not in the filter, so set the filter and add\n              filters[offset][k] ^= one;\n              added.push(k);\n            }\n          }\n        } else {\n          // filter in place - remove empty rows if necessary\n          for(i = 0; i < iterablesEmptyRows.length; i++) {\n            if(!(filters[offset][k = iterablesEmptyRows[i]] & one)) {\n              // Was in the filter, so set the filter and remove\n              filters[offset][k] ^= one;\n              removed.push(k);\n            }\n          }\n        }\n      }\n\n      lo0 = lo1;\n      hi0 = hi1;\n      filterListeners.forEach(function(l) { l(one, offset, added, removed); });\n      triggerOnChange('filtered');\n      return dimension;\n    }\n\n    // Filters this dimension using the specified range, value, or null.\n    // If the range is null, this is equivalent to filterAll.\n    // If the range is an array, this is equivalent to filterRange.\n    // Otherwise, this is equivalent to filterExact.\n    function filter(range) {\n      return range == null\n          ? filterAll() : Array.isArray(range)\n          ? filterRange(range) : typeof range === \"function\"\n          ? filterFunction(range)\n          : filterExact(range);\n    }\n\n    // Filters this dimension to select the exact value.\n    function filterExact(value) {\n      filterValue = value;\n      filterValuePresent = true;\n      return filterIndexBounds((refilter = xfilterFilter.filterExact(bisect, value))(values));\n    }\n\n    // Filters this dimension to select the specified range [lo, hi].\n    // The lower bound is inclusive, and the upper bound is exclusive.\n    function filterRange(range) {\n      filterValue = range;\n      filterValuePresent = true;\n      return filterIndexBounds((refilter = xfilterFilter.filterRange(bisect, range))(values));\n    }\n\n    // Clears any filters on this dimension.\n    function filterAll() {\n      filterValue = undefined;\n      filterValuePresent = false;\n      return filterIndexBounds((refilter = xfilterFilter.filterAll)(values));\n    }\n\n    // Filters this dimension using an arbitrary function.\n    function filterFunction(f) {\n      filterValue = f;\n      filterValuePresent = true;\n      \n      refilterFunction = f;\n      refilter = xfilterFilter.filterAll;\n\n      filterIndexFunction(f, false);\n\n      var bounds = refilter(values);\n      lo0 = bounds[0], hi0 = bounds[1];\n\n      return dimension;\n    }\n\n    function filterIndexFunction(f, filterAll) {\n      var i,\n          k,\n          x,\n          added = [],\n          removed = [],\n          valueIndexAdded = [],\n          valueIndexRemoved = [],\n          indexLength = values.length;\n\n      if(!iterable) {\n        for (i = 0; i < indexLength; ++i) {\n          if (!(filters[offset][k = index[i]] & one) ^ !!(x = f(values[i], i))) {\n            if (x) added.push(k);\n            else removed.push(k);\n          }\n        }\n      }\n\n      if(iterable) {\n        for(i=0; i < indexLength; ++i) {\n          if(f(values[i], i)) {\n            added.push(index[i]);\n            valueIndexAdded.push(i);\n          } else {\n            removed.push(index[i]);\n            valueIndexRemoved.push(i);\n          }\n        }\n      }\n\n      if(!iterable) {\n        for(i=0; i<added.length; i++) {\n          if(filters[offset][added[i]] & one) filters[offset][added[i]] &= zero;\n        }\n\n        for(i=0; i<removed.length; i++) {\n          if(!(filters[offset][removed[i]] & one)) filters[offset][removed[i]] |= one;\n        }\n      } else {\n\n        var newAdded = [];\n        var newRemoved = [];\n        for (i = 0; i < added.length; i++) {\n          // First check this particular value needs to be added\n          if(iterablesIndexFilterStatus[valueIndexAdded[i]] === 1) {\n            iterablesIndexCount[added[i]]++\n            iterablesIndexFilterStatus[valueIndexAdded[i]] = 0;\n            if(iterablesIndexCount[added[i]] === 1) {\n              filters[offset][added[i]] ^= one;\n              newAdded.push(added[i]);\n            }\n          }\n        }\n        for (i = 0; i < removed.length; i++) {\n          // First check this particular value needs to be removed\n          if(iterablesIndexFilterStatus[valueIndexRemoved[i]] === 0) {\n            iterablesIndexCount[removed[i]]--\n            iterablesIndexFilterStatus[valueIndexRemoved[i]] = 1;\n            if(iterablesIndexCount[removed[i]] === 0) {\n              filters[offset][removed[i]] ^= one;\n              newRemoved.push(removed[i]);\n            }\n          }\n        }\n\n        added = newAdded;\n        removed = newRemoved;\n\n        // Now handle empty rows.\n        if(filterAll) {\n          for(i = 0; i < iterablesEmptyRows.length; i++) {\n            if((filters[offset][k = iterablesEmptyRows[i]] & one)) {\n              // Was not in the filter, so set the filter and add\n              filters[offset][k] ^= one;\n              added.push(k);\n            }\n          }\n        } else {\n          // filter in place - remove empty rows if necessary\n          for(i = 0; i < iterablesEmptyRows.length; i++) {\n            if(!(filters[offset][k = iterablesEmptyRows[i]] & one)) {\n              // Was in the filter, so set the filter and remove\n              filters[offset][k] ^= one;\n              removed.push(k);\n            }\n          }\n        }\n      }\n\n      filterListeners.forEach(function(l) { l(one, offset, added, removed); });\n      triggerOnChange('filtered');\n    }\n    \n    function currentFilter() {\n      return filterValue;\n    }\n    \n    function hasCurrentFilter() {\n      return filterValuePresent;\n    }\n\n    // Returns the top K selected records based on this dimension's order.\n    // Note: observes this dimension's filter, unlike group and groupAll.\n    function top(k, top_offset) {\n      var array = [],\n          i = hi0,\n          j,\n          toSkip = 0;\n\n      if(top_offset && top_offset > 0) toSkip = top_offset;\n\n      while (--i >= lo0 && k > 0) {\n        if (filters.zero(j = index[i])) {\n          if(toSkip > 0) {\n            //skip matching row\n            --toSkip;\n          } else {\n            array.push(data[j]);\n            --k;\n          }\n        }\n      }\n\n      if(iterable){\n        for(i = 0; i < iterablesEmptyRows.length && k > 0; i++) {\n          // Add row with empty iterable column at the end\n          if(filters.zero(j = iterablesEmptyRows[i])) {\n            if(toSkip > 0) {\n              //skip matching row\n              --toSkip;\n            } else {\n              array.push(data[j]);\n              --k;\n            }\n          }\n        }\n      }\n\n      return array;\n    }\n\n    // Returns the bottom K selected records based on this dimension's order.\n    // Note: observes this dimension's filter, unlike group and groupAll.\n    function bottom(k, bottom_offset) {\n      var array = [],\n          i,\n          j,\n          toSkip = 0;\n\n      if(bottom_offset && bottom_offset > 0) toSkip = bottom_offset;\n\n      if(iterable) {\n        // Add row with empty iterable column at the top\n        for(i = 0; i < iterablesEmptyRows.length && k > 0; i++) {\n          if(filters.zero(j = iterablesEmptyRows[i])) {\n            if(toSkip > 0) {\n              //skip matching row\n              --toSkip;\n            } else {\n              array.push(data[j]);\n              --k;\n            }\n          }\n        }\n      }\n\n      i = lo0;\n\n      while (i < hi0 && k > 0) {\n        if (filters.zero(j = index[i])) {\n          if(toSkip > 0) {\n            //skip matching row\n            --toSkip;\n          } else {\n            array.push(data[j]);\n            --k;\n          }\n        }\n        i++;\n      }\n\n      return array;\n    }\n\n    // Adds a new group to this dimension, using the specified key function.\n    function group(key) {\n      var group = {\n        top: top,\n        all: all,\n        reduce: reduce,\n        reduceCount: reduceCount,\n        reduceSum: reduceSum,\n        order: order,\n        orderNatural: orderNatural,\n        size: size,\n        dispose: dispose,\n        remove: dispose // for backwards-compatibility\n      };\n\n      // Ensure that this group will be removed when the dimension is removed.\n      dimensionGroups.push(group);\n\n      var groups, // array of {key, value}\n          groupIndex, // object id ↦ group id\n          groupWidth = 8,\n          groupCapacity = capacity(groupWidth),\n          k = 0, // cardinality\n          select,\n          heap,\n          reduceAdd,\n          reduceRemove,\n          reduceInitial,\n          update = cr_null,\n          reset = cr_null,\n          resetNeeded = true,\n          groupAll = key === cr_null,\n          n0old;\n\n      if (arguments.length < 1) key = cr_identity;\n\n      // The group listens to the crossfilter for when any dimension changes, so\n      // that it can update the associated reduce values. It must also listen to\n      // the parent dimension for when data is added, and compute new keys.\n      filterListeners.push(update);\n      indexListeners.push(add);\n      removeDataListeners.push(removeData);\n\n      // Incorporate any existing data into the grouping.\n      add(values, index, 0, n);\n\n      // Incorporates the specified new values into this group.\n      // This function is responsible for updating groups and groupIndex.\n      function add(newValues, newIndex, n0, n1) {\n\n        if(iterable) {\n          n0old = n0\n          n0 = values.length - newValues.length\n          n1 = newValues.length;\n        }\n\n        var oldGroups = groups,\n            reIndex = iterable ? [] : cr_index(k, groupCapacity),\n            add = reduceAdd,\n            remove = reduceRemove,\n            initial = reduceInitial,\n            k0 = k, // old cardinality\n            i0 = 0, // index of old group\n            i1 = 0, // index of new record\n            j, // object id\n            g0, // old group\n            x0, // old key\n            x1, // new key\n            g, // group to add\n            x; // key of group to add\n\n        // If a reset is needed, we don't need to update the reduce values.\n        if (resetNeeded) add = initial = cr_null;\n        if (resetNeeded) remove = initial = cr_null;\n\n        // Reset the new groups (k is a lower bound).\n        // Also, make sure that groupIndex exists and is long enough.\n        groups = new Array(k), k = 0;\n        if(iterable){\n          groupIndex = k0 ? groupIndex : [];\n        }\n        else{\n          groupIndex = k0 > 1 ? xfilterArray.arrayLengthen(groupIndex, n) : cr_index(n, groupCapacity);\n        }\n\n\n        // Get the first old key (x0 of g0), if it exists.\n        if (k0) x0 = (g0 = oldGroups[0]).key;\n\n        // Find the first new key (x1), skipping NaN keys.\n        while (i1 < n1 && !((x1 = key(newValues[i1])) >= x1)) ++i1;\n\n        // While new keys remain…\n        while (i1 < n1) {\n\n          // Determine the lesser of the two current keys; new and old.\n          // If there are no old keys remaining, then always add the new key.\n          if (g0 && x0 <= x1) {\n            g = g0, x = x0;\n\n            // Record the new index of the old group.\n            reIndex[i0] = k;\n\n            // Retrieve the next old key.\n            g0 = oldGroups[++i0];\n            if (g0) x0 = g0.key;\n          } else {\n            g = {key: x1, value: initial()}, x = x1;\n          }\n\n          // Add the lesser group.\n          groups[k] = g;\n\n          // Add any selected records belonging to the added group, while\n          // advancing the new key and populating the associated group index.\n\n          while (x1 <= x) {\n            j = newIndex[i1] + (iterable ? n0old : n0)\n\n\n            if(iterable){\n              if(groupIndex[j]){\n                groupIndex[j].push(k)\n              }\n              else{\n                groupIndex[j] = [k]\n              }\n            }\n            else{\n              groupIndex[j] = k;\n            }\n\n            // Always add new values to groups. Only remove when not in filter.\n            // This gives groups full information on data life-cycle.\n            g.value = add(g.value, data[j], true);\n            if (!filters.zeroExcept(j, offset, zero)) g.value = remove(g.value, data[j], false);\n            if (++i1 >= n1) break;\n            x1 = key(newValues[i1]);\n          }\n\n          groupIncrement();\n        }\n\n        // Add any remaining old groups that were greater th1an all new keys.\n        // No incremental reduce is needed; these groups have no new records.\n        // Also record the new index of the old group.\n        while (i0 < k0) {\n          groups[reIndex[i0] = k] = oldGroups[i0++];\n          groupIncrement();\n        }\n\n\n        // Fill in gaps with empty arrays where there may have been rows with empty iterables\n        if(iterable){\n          for (var index1 = 0; index1 < n; index1++) {\n            if(!groupIndex[index1]){\n              groupIndex[index1] = [];\n            }\n          }\n        }\n\n        // If we added any new groups before any old groups,\n        // update the group index of all the old records.\n        if(k > i0){\n          if(iterable){\n            for (i0 = 0; i0 < n0old; ++i0) {\n              for (index1 = 0; index1 < groupIndex[i0].length; index1++) {\n                groupIndex[i0][index1] = reIndex[groupIndex[i0][index1]];\n              }\n            }\n          }\n          else{\n            for (i0 = 0; i0 < n0; ++i0) {\n              groupIndex[i0] = reIndex[groupIndex[i0]];\n            }\n          }\n        }\n\n        // Modify the update and reset behavior based on the cardinality.\n        // If the cardinality is less than or equal to one, then the groupIndex\n        // is not needed. If the cardinality is zero, then there are no records\n        // and therefore no groups to update or reset. Note that we also must\n        // change the registered listener to point to the new method.\n        j = filterListeners.indexOf(update);\n        if (k > 1 || iterable) {\n          update = updateMany;\n          reset = resetMany;\n        } else {\n          if (!k && groupAll) {\n            k = 1;\n            groups = [{key: null, value: initial()}];\n          }\n          if (k === 1) {\n            update = updateOne;\n            reset = resetOne;\n          } else {\n            update = cr_null;\n            reset = cr_null;\n          }\n          groupIndex = null;\n        }\n        filterListeners[j] = update;\n\n        // Count the number of added groups,\n        // and widen the group index as needed.\n        function groupIncrement() {\n          if(iterable){\n            k++\n            return\n          }\n          if (++k === groupCapacity) {\n            reIndex = xfilterArray.arrayWiden(reIndex, groupWidth <<= 1);\n            groupIndex = xfilterArray.arrayWiden(groupIndex, groupWidth);\n            groupCapacity = capacity(groupWidth);\n          }\n        }\n      }\n\n      function removeData(reIndex) {\n        if (k > 1 || iterable) {\n          var oldK = k,\n              oldGroups = groups,\n              seenGroups = cr_index(oldK, oldK),\n              i,\n              i0,\n              j;\n\n          // Filter out non-matches by copying matching group index entries to\n          // the beginning of the array.\n          if (!iterable) {\n            for (i = 0, j = 0; i < n; ++i) {\n              if (reIndex[i] !== REMOVED_INDEX) {\n                seenGroups[groupIndex[j] = groupIndex[i]] = 1;\n                ++j;\n              }\n            }\n          } else {\n            for (i = 0, j = 0; i < n; ++i) {\n              if (reIndex[i] !== REMOVED_INDEX) {\n                groupIndex[j] = groupIndex[i];\n                for (i0 = 0; i0 < groupIndex[j].length; i0++) {\n                  seenGroups[groupIndex[j][i0]] = 1;\n                }\n                ++j;\n              }\n            }\n          }\n\n          // Reassemble groups including only those groups that were referred\n          // to by matching group index entries.  Note the new group index in\n          // seenGroups.\n          groups = [], k = 0;\n          for (i = 0; i < oldK; ++i) {\n            if (seenGroups[i]) {\n              seenGroups[i] = k++;\n              groups.push(oldGroups[i]);\n            }\n          }\n\n          if (k > 1 || iterable) {\n            // Reindex the group index using seenGroups to find the new index.\n            if (!iterable) {\n              for (i = 0; i < j; ++i) groupIndex[i] = seenGroups[groupIndex[i]];\n            } else {\n              for (i = 0; i < j; ++i) {\n                for (i0 = 0; i0 < groupIndex[i].length; ++i0) {\n                  groupIndex[i][i0] = seenGroups[groupIndex[i][i0]];\n                }\n              }\n            }\n          } else {\n            groupIndex = null;\n          }\n          filterListeners[filterListeners.indexOf(update)] = k > 1 || iterable\n              ? (reset = resetMany, update = updateMany)\n              : k === 1 ? (reset = resetOne, update = updateOne)\n              : reset = update = cr_null;\n        } else if (k === 1) {\n          if (groupAll) return;\n          for (var index3 = 0; index3 < n; ++index3) if (reIndex[index3] !== REMOVED_INDEX) return;\n          groups = [], k = 0;\n          filterListeners[filterListeners.indexOf(update)] =\n          update = reset = cr_null;\n        }\n      }\n\n      // Reduces the specified selected or deselected records.\n      // This function is only used when the cardinality is greater than 1.\n      // notFilter indicates a crossfilter.add/remove operation.\n      function updateMany(filterOne, filterOffset, added, removed, notFilter) {\n\n        if ((filterOne === one && filterOffset === offset) || resetNeeded) return;\n\n        var i,\n            j,\n            k,\n            n,\n            g;\n\n        if(iterable){\n          // Add the added values.\n          for (i = 0, n = added.length; i < n; ++i) {\n            if (filters.zeroExcept(k = added[i], offset, zero)) {\n              for (j = 0; j < groupIndex[k].length; j++) {\n                g = groups[groupIndex[k][j]];\n                g.value = reduceAdd(g.value, data[k], false, j);\n              }\n            }\n          }\n\n          // Remove the removed values.\n          for (i = 0, n = removed.length; i < n; ++i) {\n            if (filters.onlyExcept(k = removed[i], offset, zero, filterOffset, filterOne)) {\n              for (j = 0; j < groupIndex[k].length; j++) {\n                g = groups[groupIndex[k][j]];\n                g.value = reduceRemove(g.value, data[k], notFilter, j);\n              }\n            }\n          }\n          return;\n        }\n\n        // Add the added values.\n        for (i = 0, n = added.length; i < n; ++i) {\n          if (filters.zeroExcept(k = added[i], offset, zero)) {\n            g = groups[groupIndex[k]];\n            g.value = reduceAdd(g.value, data[k], false);\n          }\n        }\n\n        // Remove the removed values.\n        for (i = 0, n = removed.length; i < n; ++i) {\n          if (filters.onlyExcept(k = removed[i], offset, zero, filterOffset, filterOne)) {\n            g = groups[groupIndex[k]];\n            g.value = reduceRemove(g.value, data[k], notFilter);\n          }\n        }\n      }\n\n      // Reduces the specified selected or deselected records.\n      // This function is only used when the cardinality is 1.\n      // notFilter indicates a crossfilter.add/remove operation.\n      function updateOne(filterOne, filterOffset, added, removed, notFilter) {\n        if ((filterOne === one && filterOffset === offset) || resetNeeded) return;\n\n        var i,\n            k,\n            n,\n            g = groups[0];\n\n        // Add the added values.\n        for (i = 0, n = added.length; i < n; ++i) {\n          if (filters.zeroExcept(k = added[i], offset, zero)) {\n            g.value = reduceAdd(g.value, data[k], false);\n          }\n        }\n\n        // Remove the removed values.\n        for (i = 0, n = removed.length; i < n; ++i) {\n          if (filters.onlyExcept(k = removed[i], offset, zero, filterOffset, filterOne)) {\n            g.value = reduceRemove(g.value, data[k], notFilter);\n          }\n        }\n      }\n\n      // Recomputes the group reduce values from scratch.\n      // This function is only used when the cardinality is greater than 1.\n      function resetMany() {\n        var i,\n            j,\n            g;\n\n        // Reset all group values.\n        for (i = 0; i < k; ++i) {\n          groups[i].value = reduceInitial();\n        }\n\n        // We add all records and then remove filtered records so that reducers\n        // can build an 'unfiltered' view even if there are already filters in\n        // place on other dimensions.\n        if(iterable){\n          for (i = 0; i < n; ++i) {\n            for (j = 0; j < groupIndex[i].length; j++) {\n              g = groups[groupIndex[i][j]];\n              g.value = reduceAdd(g.value, data[i], true, j);\n            }\n          }\n          for (i = 0; i < n; ++i) {\n            if (!filters.zeroExcept(i, offset, zero)) {\n              for (j = 0; j < groupIndex[i].length; j++) {\n                g = groups[groupIndex[i][j]];\n                g.value = reduceRemove(g.value, data[i], false, j);\n              }\n            }\n          }\n          return;\n        }\n\n        for (i = 0; i < n; ++i) {\n          g = groups[groupIndex[i]];\n          g.value = reduceAdd(g.value, data[i], true);\n        }\n        for (i = 0; i < n; ++i) {\n          if (!filters.zeroExcept(i, offset, zero)) {\n            g = groups[groupIndex[i]];\n            g.value = reduceRemove(g.value, data[i], false);\n          }\n        }\n      }\n\n      // Recomputes the group reduce values from scratch.\n      // This function is only used when the cardinality is 1.\n      function resetOne() {\n        var i,\n            g = groups[0];\n\n        // Reset the singleton group values.\n        g.value = reduceInitial();\n\n        // We add all records and then remove filtered records so that reducers\n        // can build an 'unfiltered' view even if there are already filters in\n        // place on other dimensions.\n        for (i = 0; i < n; ++i) {\n          g.value = reduceAdd(g.value, data[i], true);\n        }\n\n        for (i = 0; i < n; ++i) {\n          if (!filters.zeroExcept(i, offset, zero)) {\n            g.value = reduceRemove(g.value, data[i], false);\n          }\n        }\n      }\n\n      // Returns the array of group values, in the dimension's natural order.\n      function all() {\n        if (resetNeeded) reset(), resetNeeded = false;\n        return groups;\n      }\n\n      // Returns a new array containing the top K group values, in reduce order.\n      function top(k) {\n        var top = select(all(), 0, groups.length, k);\n        return heap.sort(top, 0, top.length);\n      }\n\n      // Sets the reduce behavior for this group to use the specified functions.\n      // This method lazily recomputes the reduce values, waiting until needed.\n      function reduce(add, remove, initial) {\n        reduceAdd = add;\n        reduceRemove = remove;\n        reduceInitial = initial;\n        resetNeeded = true;\n        return group;\n      }\n\n      // A convenience method for reducing by count.\n      function reduceCount() {\n        return reduce(xfilterReduce.reduceIncrement, xfilterReduce.reduceDecrement, cr_zero);\n      }\n\n      // A convenience method for reducing by sum(value).\n      function reduceSum(value) {\n        return reduce(xfilterReduce.reduceAdd(value), xfilterReduce.reduceSubtract(value), cr_zero);\n      }\n\n      // Sets the reduce order, using the specified accessor.\n      function order(value) {\n        select = xfilterHeapselect.by(valueOf);\n        heap = xfilterHeap.by(valueOf);\n        function valueOf(d) { return value(d.value); }\n        return group;\n      }\n\n      // A convenience method for natural ordering by reduce value.\n      function orderNatural() {\n        return order(cr_identity);\n      }\n\n      // Returns the cardinality of this group, irrespective of any filters.\n      function size() {\n        return k;\n      }\n\n      // Removes this group and associated event listeners.\n      function dispose() {\n        var i = filterListeners.indexOf(update);\n        if (i >= 0) filterListeners.splice(i, 1);\n        i = indexListeners.indexOf(add);\n        if (i >= 0) indexListeners.splice(i, 1);\n        i = removeDataListeners.indexOf(removeData);\n        if (i >= 0) removeDataListeners.splice(i, 1);\n        i = dimensionGroups.indexOf(group);\n        if (i >= 0) dimensionGroups.splice(i, 1);\n        return group;\n      }\n\n      return reduceCount().orderNatural();\n    }\n\n    // A convenience function for generating a singleton group.\n    function groupAll() {\n      var g = group(cr_null), all = g.all;\n      delete g.all;\n      delete g.top;\n      delete g.order;\n      delete g.orderNatural;\n      delete g.size;\n      g.value = function() { return all()[0].value; };\n      return g;\n    }\n\n    // Removes this dimension and associated groups and event listeners.\n    function dispose() {\n      dimensionGroups.forEach(function(group) { group.dispose(); });\n      var i = dataListeners.indexOf(preAdd);\n      if (i >= 0) dataListeners.splice(i, 1);\n      i = dataListeners.indexOf(postAdd);\n      if (i >= 0) dataListeners.splice(i, 1);\n      i = removeDataListeners.indexOf(removeData);\n      if (i >= 0) removeDataListeners.splice(i, 1);\n      filters.masks[offset] &= zero;\n      return filterAll();\n    }\n\n    return dimension;\n  }\n\n  // A convenience method for groupAll on a dummy dimension.\n  // This implementation can be optimized since it always has cardinality 1.\n  function groupAll() {\n    var group = {\n      reduce: reduce,\n      reduceCount: reduceCount,\n      reduceSum: reduceSum,\n      value: value,\n      dispose: dispose,\n      remove: dispose // for backwards-compatibility\n    };\n\n    var reduceValue,\n        reduceAdd,\n        reduceRemove,\n        reduceInitial,\n        resetNeeded = true;\n\n    // The group listens to the crossfilter for when any dimension changes, so\n    // that it can update the reduce value. It must also listen to the parent\n    // dimension for when data is added.\n    filterListeners.push(update);\n    dataListeners.push(add);\n\n    // For consistency; actually a no-op since resetNeeded is true.\n    add(data, 0, n);\n\n    // Incorporates the specified new values into this group.\n    function add(newData, n0) {\n      var i;\n\n      if (resetNeeded) return;\n\n      // Cycle through all the values.\n      for (i = n0; i < n; ++i) {\n\n        // Add all values all the time.\n        reduceValue = reduceAdd(reduceValue, data[i], true);\n\n        // Remove the value if filtered.\n        if (!filters.zero(i)) {\n          reduceValue = reduceRemove(reduceValue, data[i], false);\n        }\n      }\n    }\n\n    // Reduces the specified selected or deselected records.\n    function update(filterOne, filterOffset, added, removed, notFilter) {\n      var i,\n          k,\n          n;\n\n      if (resetNeeded) return;\n\n      // Add the added values.\n      for (i = 0, n = added.length; i < n; ++i) {\n        if (filters.zero(k = added[i])) {\n          reduceValue = reduceAdd(reduceValue, data[k], notFilter);\n        }\n      }\n\n      // Remove the removed values.\n      for (i = 0, n = removed.length; i < n; ++i) {\n        if (filters.only(k = removed[i], filterOffset, filterOne)) {\n          reduceValue = reduceRemove(reduceValue, data[k], notFilter);\n        }\n      }\n    }\n\n    // Recomputes the group reduce value from scratch.\n    function reset() {\n      var i;\n\n      reduceValue = reduceInitial();\n\n      // Cycle through all the values.\n      for (i = 0; i < n; ++i) {\n\n        // Add all values all the time.\n        reduceValue = reduceAdd(reduceValue, data[i], true);\n\n        // Remove the value if it is filtered.\n        if (!filters.zero(i)) {\n          reduceValue = reduceRemove(reduceValue, data[i], false);\n        }\n      }\n    }\n\n    // Sets the reduce behavior for this group to use the specified functions.\n    // This method lazily recomputes the reduce value, waiting until needed.\n    function reduce(add, remove, initial) {\n      reduceAdd = add;\n      reduceRemove = remove;\n      reduceInitial = initial;\n      resetNeeded = true;\n      return group;\n    }\n\n    // A convenience method for reducing by count.\n    function reduceCount() {\n      return reduce(xfilterReduce.reduceIncrement, xfilterReduce.reduceDecrement, cr_zero);\n    }\n\n    // A convenience method for reducing by sum(value).\n    function reduceSum(value) {\n      return reduce(xfilterReduce.reduceAdd(value), xfilterReduce.reduceSubtract(value), cr_zero);\n    }\n\n    // Returns the computed reduce value.\n    function value() {\n      if (resetNeeded) reset(), resetNeeded = false;\n      return reduceValue;\n    }\n\n    // Removes this group and associated event listeners.\n    function dispose() {\n      var i = filterListeners.indexOf(update);\n      if (i >= 0) filterListeners.splice(i, 1);\n      i = dataListeners.indexOf(add);\n      if (i >= 0) dataListeners.splice(i, 1);\n      return group;\n    }\n\n    return reduceCount();\n  }\n\n  // Returns the number of records in this crossfilter, irrespective of any filters.\n  function size() {\n    return n;\n  }\n\n  // Returns the raw row data contained in this crossfilter\n  function all(){\n    return data;\n  }\n\n  // Returns row data with all dimension filters applied, except for filters in ignore_dimensions\n  function allFiltered(ignore_dimensions) {\n    var array = [],\n        i = 0,\n        mask = maskForDimensions(ignore_dimensions || []);\n\n      for (i = 0; i < n; i++) {\n        if (filters.zeroExceptMask(i, mask)) {\n          array.push(data[i]);\n        }\n      }\n\n      return array;\n  }\n\n  function onChange(cb){\n    if(typeof cb !== 'function'){\n      /* eslint no-console: 0 */\n      console.warn('onChange callback parameter must be a function!');\n      return;\n    }\n    callbacks.push(cb);\n    return function(){\n      callbacks.splice(callbacks.indexOf(cb), 1);\n    };\n  }\n\n  function triggerOnChange(eventName){\n    for (var i = 0; i < callbacks.length; i++) {\n      callbacks[i](eventName);\n    }\n  }\n\n  return arguments.length\n      ? add(arguments[0])\n      : crossfilter;\n}\n\n// Returns an array of size n, big enough to store ids up to m.\nfunction cr_index(n, m) {\n  return (m < 0x101\n      ? xfilterArray.array8 : m < 0x10001\n      ? xfilterArray.array16\n      : xfilterArray.array32)(n);\n}\n\n// Constructs a new array of size n, with sequential values from 0 to n - 1.\nfunction cr_range(n) {\n  var range = cr_index(n, n);\n  for (var i = -1; ++i < n;) range[i] = i;\n  return range;\n}\n\nfunction capacity(w) {\n  return w === 8\n      ? 0x100 : w === 16\n      ? 0x10000\n      : 0x100000000;\n}\n","import {d3} from './lib';\nimport crossfilter from 'crossfilter2';\n\n/* Decompresses ideogram's annotations for crossfilter initialization\nBy default, annotations are clustered by chromosome, e.g.\n[\n  {\"chr\": \"1\", \"annots\": [{\"from\": 100, \"to\", 101, \"chr\": \"1\", ...}, ...]},\n  {\"chr\": \"2\", \"annots\": [{\"from\": 500, \"to\", 501, \"chr\": \"2\", ...}, ...]},\n  ...\n]\nThis method flattens that structure to e.g.\n[\n  {\"from\": 100, \"to\": 101, \"chr\": \"1\", ...},\n  ...\n  {\"from\": 500, \"to\": 501, \"chr\": \"2\", ...},\n]\nSee also: packAnnots\n*/\nfunction unpackAnnots() {\n  var chr, annots, i,\n    unpackedAnnots = [],\n    ideo = this,\n    chrs = ideo.annots;\n\n  for (i = 0; i < chrs.length; i++) {\n    chr = chrs[i];\n    annots = chr.annots;\n    unpackedAnnots = unpackedAnnots.concat(annots);\n  }\n\n  return unpackedAnnots;\n}\n\n/*\n  Compresses annots back to default state.  Inverse of unpackAnnots.\n*/\nfunction packAnnots(unpackedAnnots) {\n  var chr, annot, i,\n    annots = [],\n    ideo = this,\n    chrs = ideo.annots;\n\n  for (chr in chrs) {\n    annots.push({chr: chrs[chr].chr, annots: []});\n  }\n\n  for (i = 0; i < unpackedAnnots.length; i++) {\n    annot = unpackedAnnots[i];\n    annots[annot.chrIndex].annots.push(annot);\n  }\n\n  return annots;\n}\n\n/*\n  Initializes crossfilter.  Needed for client-side filtering.\n  More: https://github.com/square/crossfilter/wiki/API-Reference\n*/\nfunction initCrossFilter() {\n  var i, facet,\n    ideo = this,\n    keys = ideo.rawAnnots.keys;\n\n  ideo.unpackedAnnots = ideo.unpackAnnots();\n  ideo.crossfilter = crossfilter(ideo.unpackedAnnots);\n\n  ideo.annotsByFacet = {};\n  ideo.facets = keys.slice(3, keys.length);\n\n  for (i = 0; i < ideo.facets.length; i++) {\n    facet = ideo.facets[i];\n    ideo.annotsByFacet[facet] =\n      ideo.crossfilter.dimension(function(d) {\n        return d[facet];\n      });\n  }\n\n  if ('filterSelections' in ideo) {\n    ideo.filterAnnots(ideo.filterSelections);\n  }\n\n  ideo.filteredAnnots = ideo.annots;\n}\n\nfunction getFilteredResults(selections, ideo) {\n  var fn, i, facet, results, filter,\n    counts = {};\n\n  if (Object.keys(selections).length === 0) {\n    results = ideo.unpackedAnnots;\n  } else {\n    for (i = 0; i < ideo.facets.length; i++) {\n      facet = ideo.facets[i];\n      if (facet in selections) {\n        filter = selections[facet];\n        if (Array.isArray(filter)) {\n          fn = function(d) {\n            // Filter is numeric range\n            if (filter.length === 2) {\n              // [min, max]\n              return filter[0] <= d && d < filter[1];\n            } else if (filter.length === 4) {\n              // [min1, max1, min2, max2]\n              return (\n                filter[0] <= d && d < filter[1] ||\n                filter[2] <= d && d < filter[3]\n              );\n            }\n          };\n        } else {\n          fn = function(d) {\n            // Filter is set of categories\n            return (d in filter);\n          };\n        }\n      } else {\n        fn = null;\n      }\n      ideo.annotsByFacet[facet].filter(fn);\n      counts[facet] = ideo.annotsByFacet[facet].group().top(Infinity);\n    }\n    results = ideo.annotsByFacet[facet].top(Infinity);\n  }\n\n  return [results, counts];\n}\n\n/*\n  Filters annotations based on the given selections.\n  \"selections\" is an object of objects, e.g.\n\n    {\n      \"tissue-type\": {          <-- a facet\n        \"cerebral-cortex\": 1,   <-- a filter; \"1\" means it is selected\n        \"liver\": 1\n      },\n      \"gene-type\": {\n        mirna\": 1\n      }\n    }\n\n  Translation:\n  select where:\n      (tissue-type is cerebral-cortex OR liver) and (gene-type is mirna)\n\n  TODO:\n    * Filter counts\n    * Integrate server-side filtering for very large datasets\n*/\nfunction filterAnnots(selections) {\n  var i, facet, results, counts,\n    t0 = Date.now(),\n    ideo = this;\n\n  ideo.filterSelections = selections;\n  [results, counts] = getFilteredResults(selections, ideo);\n\n  for (i < 0; i < ideo.facets.length; i++) {\n    ideo.annotsByFacet[facet].filterAll(); // clear filters\n  }\n\n  results = ideo.packAnnots(results);\n\n  delete ideo.maxAnnotsPerBar;\n  delete ideo.maxAnnotsPerBarAllChrs;\n\n  ideo.filteredAnnots = results;\n\n  d3.selectAll(ideo.selector + ' polygon.annot').remove();\n  ideo.drawAnnots(results);\n\n  console.log('Time in filterAnnots: ' + (Date.now() - t0) + ' ms');\n\n  return counts;\n}\n\nexport {unpackAnnots, packAnnots, initCrossFilter, filterAnnots};\n","function getPixelAndOtherData(bands, chr, hasBands, ideo) {\n  var i, band, csLength, width, maxLength,\n    pxStop = 0,\n    taxid = chr.id.split('-')[1],\n    cs = ideo.coordinateSystem,\n    chrHeight = ideo.config.chrHeight;\n\n  for (i = 0; i < bands.length; i++) {\n    band = bands[i];\n    csLength = band[cs].stop - band[cs].start;\n\n    // If ideogram is rotated (and thus showing only one chromosome),\n    // then set its width independent of the longest chromosome in this\n    // genome.\n    if (ideo._layout._isRotated) {\n      width = chrHeight * csLength / chr.length;\n    } else {\n      if (ideo.config.chromosomeScale === 'relative') {\n        maxLength = ideo.maxLength[taxid][cs];\n      } else {\n        maxLength = ideo.maxLength[cs];\n      }\n      width = chrHeight * chr.length / maxLength * csLength / chr.length;\n    }\n    bands[i].px = {start: pxStop, stop: pxStop + width, width: width};\n\n    pxStop = bands[i].px.stop;\n\n    if (hasBands && band.stain === 'acen' && band.name[0] === 'p') {\n      chr.pcenIndex = i;\n    }\n  }\n  return [bands, chr, pxStop];\n}\n\n/**\n * TODO:\n * A chromosome-level scale property is likely\n * nonsensical for any chromosomes that have cytogenetic band data.\n * Different bands tend to have ratios between number of base pairs\n * and physical length.\n *\n * However, a chromosome-level scale property is likely\n * necessary for chromosomes that do not have band data.\n *\n * This needs further review.\n */\nfunction getChrScale(chr, hasBands, ideo) {\n  var chrHeight = ideo.config.chrHeight,\n    chrLength = chr.length,\n    maxLength = ideo.maxLength,\n    taxid = chr.id.split('-')[1],\n    scale = {};\n\n  scale.bp = chrHeight / maxLength.bp;\n\n  if (ideo.config.multiorganism === true) {\n    // chr.scale.bp = band.iscn.stop / band.bp.stop;\n    if (ideo.config.chromosomeScale === 'relative') {\n      scale.iscn = chrHeight * chrLength / maxLength[taxid].bp;\n      scale.bp = chrHeight / maxLength[taxid].bp;\n    } else {\n      scale.iscn = chrHeight * chrLength / maxLength.bp;\n    }\n  } else if (hasBands) {\n    scale.iscn = chrHeight / maxLength.iscn;\n  }\n\n  return scale;\n}\n\nfunction getChromosomePixels(chr) {\n  var bands, chrHeight, pxStop, hasBands, maxLength,\n    taxid = chr.id.split('-')[1],\n    ideo = this;\n\n  bands = chr.bands;\n  chrHeight = ideo.config.chrHeight;\n  pxStop = 0;\n  hasBands = (typeof bands !== 'undefined');\n\n  if (hasBands) {\n    [bands, chr, pxStop] = getPixelAndOtherData(bands, chr, hasBands, ideo);\n  } else {\n    if (ideo.config.chromosomeScale === 'relative') {\n      maxLength = ideo.maxLength[taxid][ideo.coordinateSystem];\n    } else {\n      maxLength = ideo.maxLength[ideo.coordinateSystem];\n    }\n    pxStop = chrHeight * chr.length / maxLength;\n  }\n\n  chr.width = pxStop;\n  chr.scale = getChrScale(chr, hasBands, ideo);\n  chr.bands = bands;\n\n  return chr;\n}\n\nfunction getChrModelScaffold(chr, bands, chrName, ideo) {\n  var hasBands = (typeof bands !== 'undefined');\n\n  if (hasBands) {\n    const lastBand = bands.slice(-1)[0];\n    chr.name = chrName;\n    chr.length = lastBand[ideo.coordinateSystem].stop;\n\n    // Accounts for case where this chromosome\n    chr.bpLength = lastBand.bp.stop;\n\n    chr.type = 'nuclear';\n  } else {\n    chr = chrName;\n  }\n\n  return chr;\n}\n\n/**\n * Encountered when processing an assembly that has chromosomes with\n * centromere data, but this chromosome does not.\n * Example: chromosome F1 in Felis catus.\n */\nfunction deleteExtraneousBands(chr, hasBands) {\n  if (hasBands && chr.bands.length === 1) {\n    delete chr.bands;\n  }\n  return chr;\n}\n\nfunction getCentromerePosition(hasBands, bands) {\n\n  if (hasBands === false) return '';\n\n  // As with Macaca mulatta chromosome Y\n  const firstBand = bands[0];\n  const lastBand = bands.slice(-1)[0];\n  const chrLength = lastBand.bp.stop - firstBand.bp.start;\n  const smallLength = chrLength/20;\n\n  if (\n    // As with almost all mouse chromosome, chimpanzee chr22\n    firstBand.name[0] === 'p' && bands[1].name[0] === 'q' &&\n    firstBand.bp.stop - firstBand.bp.start < smallLength\n  ) {\n    return 'telocentric-p';\n  }\n\n  const penultimateBand = bands.slice(-2)[0];\n\n  if (\n    penultimateBand.name[0] === 'p' && lastBand.name[0] === 'q' &&\n    lastBand.bp.stop - lastBand.bp.start < smallLength\n  ) {\n    // As with Macaca mulatta chromosome Y\n    return 'telocentric-q';\n  }\n\n  return '';\n}\n\n/**\n * Generates a model object for each chromosome containing information on\n * its name, DOM ID, length in base pairs or ISCN coordinates, cytogenetic\n * bands, centromere position, etc.\n */\nfunction getChromosomeModel(bands, chrName, taxid, chrIndex) {\n  var hasBands, org,\n    chr = {},\n    ideo = this;\n\n  hasBands = (typeof bands !== 'undefined');\n\n  chr = getChrModelScaffold(chr, bands, chrName, ideo);\n\n  chr.chrIndex = chrIndex;\n  chr.id = 'chr' + chr.name + '-' + taxid;\n\n  if (ideo.config.fullChromosomeLabels === true) {\n    org = this.organisms[taxid];\n    chr.name = org.scientificName + ' chr' + chr.name;\n  }\n\n  chr.bands = bands;\n  chr = ideo.getChromosomePixels(chr);\n  chr.centromerePosition = getCentromerePosition(hasBands, bands);\n\n  chr = deleteExtraneousBands(chr, hasBands);\n\n  return chr;\n}\n\nexport {getChromosomeModel, getChromosomePixels};\n","// import {getSettings, handleSettingsHeaderClick} from './settings-ui';\nimport version from '../version';\nimport {downloadPng} from '../lib';\n\nconst style = `\n  <style>\n\n    #gear {\n      position: absolute;\n      right: 3px;\n      top: 24px;\n      z-index: 8001;\n      cursor: pointer;\n      height: 18px;\n      width: 18px;\n    }\n\n    #tools {\n      position: absolute;\n      width: 120px;\n      right: 27px;\n      top: 16px;\n      z-index: 8000;\n      background: white;\n      margin: 0;\n      border: 1px solid #CCC;\n      border-radius: 4px;\n      box-shadow: -2px 4px 6px #CCC;\n    }\n\n    #tools ul {\n      margin-block-start: 0;\n      margin-block-end: 0;\n      padding-inline-start: 0;\n    }\n\n    #tools li, #download li {\n      padding: 2px 12px 2px 12px;\n      cursor: pointer;\n    }\n\n    #tools li:hover,\n    #tools li.active,\n    #download li:hover {\n      background: #DDD;\n    }\n\n    #tools li.ideo-disabled,\n    #tools li.active.ideo-disabled,\n    #download li.ideo-disabled {\n      background: #FFF;\n      color: #CCC;\n      cursor: default;\n    }\n\n    #download {\n      position: absolute;\n      right: 3px;\n      top: 16px;\n      z-index: 8000;\n      background: white;\n      margin: 0;\n      padding-inline-start: 0;\n    }\n\n    #settings {\n      position: absolute;\n      right: 3px;\n      top: 16px;\n      z-index: 8000;\n      background: white;\n      margin: 0;\n      padding-inline-start: 0;\n    }\n\n    #about {\n      position: absolute;\n      right: 24px;\n      top: -8px;\n      z-index: 8000;\n      background: white;\n      width: 300px;\n      border: 1px solid #CCC;\n      padding: 10px;\n      border-radius: 4px;\n      box-shadow: -2px 4px 6px #CCC;\n      cursor: default;\n    }\n\n    #close {\n      float: right;\n      border: 1px solid #DDD;\n      border-radius: 4px;\n      padding: 0 6px;\n      background: #EEE;\n      font-weight: bold;\n      cursor: pointer;\n    }\n\n    #settings label {\n      display: inline;\n      text-decoration: underline;\n      text-decoration-style: dotted;\n      cursor: pointer;\n    }\n\n    #download {\n      position: absolute;\n      width: 120px;\n      top: -2px;\n      right: 120px;\n      z-index: 8000;\n      background: white;\n      margin: 0;\n      border: 1px solid #CCC;\n      border-radius: 4px;\n      box-shadow: -2px 4px 6px #CCC;\n    }\n\n    li {\n      list-style-type: none;\n    }\n\n    #settings .no-underline {\n      text-decoration: none;\n    }\n\n    #settings .setting {\n      margin-right: 8px;\n    }\n\n    #settings input[type=\"checkbox\"], #settings input[type=\"radio\"] {\n      position: relative;\n      top: 2px;\n    }\n\n    .area-header {\n      font-size: 16px;\n      font-weight: bold;\n      margin-bottom: 10px;\n      clear: both;\n    }\n\n    .area-content {\n      display: flex;\n      flex-wrap: wrap;\n    }\n\n    .area-content > div {\n      margin-right: 30px;\n      margin-bottom: 15px;\n    }\n\n    .tab-panel input[type=\"number\"] {\n      width: 50px;\n    }\n\n    .tab-panel ul {\n      width: 600px;\n      list-style: none;\n      border-bottom: 1px solid #CCC;\n      box-sizing: border-box;\n      margin-bottom: 0;\n      padding-left: 0;\n    }\n\n    .tab-panel .nav:before, .tab-panel .nav:after {\n      content: \" \";\n      display: table;\n      clear: both;\n    }\n\n    .tab-panel li {\n      float: left;\n      margin-right: 2px;\n      display: block;\n      margin-bottom: -1px;\n    }\n\n    .tab-panel li > a {\n      padding: 10px 15px;\n      text-decoration: none;\n      border-radius: 4px 4px 0 0;\n      display: block;\n      position: relative;\n    }\n\n    .tab-panel li.active > a {\n      border: 1px solid #CCC;\n      border-bottom: none;\n      background-color: white;\n    }\n\n    .tab-panel .tab-content {\n      width: 600px;\n    }\n\n    .tab-panel .tab-content > div {\n      display: none;\n      padding-top: 20px;\n      clear: both;\n    }\n\n    .tab-panel .tab-content > div {\n      padding: 20px 10px 5px 10px;\n    }\n\n    .tab-panel .tab-content > div.active {\n      display: block;\n      border: 1px solid #CCC;\n      border-top: none;\n    }\n\n  </style>`;\n\n// eslint-disable-next-line max-len\nconst gearIcon = '<svg viewBox=\"0 0 512 512\"><path fill=\"#AAA\" d=\"M444.788 291.1l42.616 24.599c4.867 2.809 7.126 8.618 5.459 13.985-11.07 35.642-29.97 67.842-54.689 94.586a12.016 12.016 0 0 1-14.832 2.254l-42.584-24.595a191.577 191.577 0 0 1-60.759 35.13v49.182a12.01 12.01 0 0 1-9.377 11.718c-34.956 7.85-72.499 8.256-109.219.007-5.49-1.233-9.403-6.096-9.403-11.723v-49.184a191.555 191.555 0 0 1-60.759-35.13l-42.584 24.595a12.016 12.016 0 0 1-14.832-2.254c-24.718-26.744-43.619-58.944-54.689-94.586-1.667-5.366.592-11.175 5.459-13.985L67.212 291.1a193.48 193.48 0 0 1 0-70.199l-42.616-24.599c-4.867-2.809-7.126-8.618-5.459-13.985 11.07-35.642 29.97-67.842 54.689-94.586a12.016 12.016 0 0 1 14.832-2.254l42.584 24.595a191.577 191.577 0 0 1 60.759-35.13V25.759a12.01 12.01 0 0 1 9.377-11.718c34.956-7.85 72.499-8.256 109.219-.007 5.49 1.233 9.403 6.096 9.403 11.723v49.184a191.555 191.555 0 0 1 60.759 35.13l42.584-24.595a12.016 12.016 0 0 1 14.832 2.254c24.718 26.744 43.619 58.944 54.689 94.586 1.667 5.366-.592 11.175-5.459 13.985L444.788 220.9a193.485 193.485 0 0 1 0 70.2zM336 256c0-44.112-35.888-80-80-80s-80 35.888-80 80 35.888 80 80 80 80-35.888 80-80z\"/></svg>';\n// Font Awesome Free 5.2.0 by @fontawesome - https://fontawesome.com\n// License - https://fontawesome.com/license (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License)\n\nfunction deactivate(items) {\n  items.forEach(item => {item.classList.remove('active');});\n}\n\nfunction closeTools() {\n  const toolHeaders = document.querySelectorAll('#tools > ul > li');\n  deactivate(toolHeaders);\n  const itemsToClose =\n    document.querySelectorAll('.ideo-modal, .ideo-tool-panel');\n  itemsToClose.forEach(item => {item.remove();});\n\n  document.querySelector('#tools').style.display = 'none';\n}\n\n/**\n * As needed, hide tool panels that are triggered by hovering\n */\nfunction handleHideForHoverables(trigger, tool, toolHeader, toolHeaders) {\n  if (trigger === 'mouseenter') {\n\n    // Hide panel when hover leaves tool header, if new target element\n    // is part of the tools UI (and not the panel itself)\n    toolHeader.addEventListener('mouseleave', event => {\n      const toElement = event.toElement;\n      const toId = toElement.id;\n      const panelElement = document.querySelector('.ideo-tool-panel');\n      const toolsElement = document.querySelector('#tools');\n      if (\n        toolsElement.contains(toElement) &&\n        panelElement && !panelElement.contains(toElement) &&\n        toId !== tool\n      ) {\n        deactivate(toolHeaders);\n        panelElement.remove();\n      }\n    });\n  }\n}\n\n/** Determine action that should trigger a tool panel to display */\nfunction getTrigger(toolHeader) {\n  const shouldHover =\n    Array.from(toolHeader.classList).includes('ideo-tool-hover');\n  const trigger = shouldHover ? 'mouseenter' : 'click';\n  return trigger;\n}\n\n/** Shows clicked tool as active, displays resulting panel */\nfunction handleToolClick(ideo) {\n  const toolHeaders = document.querySelectorAll('#tools > ul > li');\n\n  toolHeaders.forEach(toolHeader => {\n    const trigger = getTrigger(toolHeader);\n\n    toolHeader.addEventListener(trigger, event => {\n\n      // Show only clicked tool header as active\n      deactivate(toolHeaders);\n      toolHeader.classList += ' active';\n\n      const tool = toolHeader.id.split('-')[0];\n      const panel = getPanel(tool, ideo);\n\n      if (trigger === 'mouseenter') {\n        toolHeader.insertAdjacentHTML('beforeend', panel);\n        handleHideForHoverables(trigger, tool, toolHeader, toolHeaders);\n\n        if (tool === 'download') {\n          document.querySelector('#download-image')\n            .addEventListener('click', event => {\n              closeTools();\n              downloadPng(ideo);\n            });\n\n          document.querySelector('#download-annots')\n            .addEventListener('click', event => {\n              const element = document.querySelector('#download-annots');\n              const classes = Array.from(element.classList);\n              if (classes.includes('ideo-disabled') === false) {\n                closeTools();\n                ideo.downloadAnnotations();\n              }\n            });\n        }\n      } else {\n        document.querySelector('#gear').insertAdjacentHTML('beforeend', panel);\n      }\n    });\n  });\n\n  // Upon clicking \"close\" (x), remove tools UI\n  document.querySelectorAll('#close').forEach(closeButton => {\n    closeButton.addEventListener('click', () => {closeTools();});\n  });\n\n}\n\nfunction handleGearClick(ideo) {\n  document.querySelector('#gear')\n    .addEventListener('click', event => {\n      var options = document.querySelector('#tools');\n      if (options.style.display === 'none') {\n        options.style.display = '';\n        hideOnClickOutside();\n      } else {\n        options.style.display = 'none';\n        closeTools();\n      }\n    });\n\n  handleToolClick(ideo);\n\n  // handleSettingsHeaderClick(ideo);\n}\n\nfunction showGearOnIdeogramHover(ideo) {\n  const container = document.querySelector(ideo.selector);\n  const gear = document.querySelector('#gear');\n  const panel = document.querySelector('#tools');\n\n  container.addEventListener('mouseover', () => gear.style.display = '');\n  container.addEventListener('mouseout', () => {\n    // Hide gear only if panel is not shown\n    if (panel.style.display === 'none') {\n      gear.style.display = 'none';\n    }\n  });\n\n  gear.addEventListener('mouseover', () => gear.style.display = '');\n}\n\nfunction getPanel(tool, ideo) {\n  var panel;\n  // if (tool === 'settings') panel = getSettings();\n  if (tool === 'download') panel = getDownload(ideo);\n  if (tool === 'about') panel = getAbout();\n  return panel.trim();\n}\n\nfunction getDownload(ideo) {\n\n  const numAnnots = document.querySelectorAll('.annot').length;\n  const annotsClass = (numAnnots > 0) ? '' : 'ideo-disabled';\n\n  return `\n    <div id=\"download\" class=\"ideo-tool-panel\">\n      <li id=\"download-image\">Image</li>\n      <li id=\"download-annots\" class=\"${annotsClass}\">Annotations</li>\n    </div>\n  `;\n}\n\nfunction getAbout() {\n  const ideogramLink = `\n    <a href=\"https://github.com/eweitz/ideogram\" target=\"_blank\" rel=\"noopener\">\n      Ideogram.js</a>`;\n  const closeButton = '<span id=\"close\">x</span>';\n  return `\n    <div id=\"about\" class=\"ideo-modal\">\n      ${ideogramLink}, version ${version} ${closeButton}<br/>\n      <i>Chromosome visualization for the web</i>\n    </div>`;\n}\n\nfunction hideOnClickOutside(selector) {\n  const elements = document.querySelectorAll('#gear, #tools');\n  const outsideClickListener = event => {\n    let clickedOutsideCount = 0;\n    elements.forEach((element) => {\n      if (!element.contains(event.target)) {\n        clickedOutsideCount += 1;\n      }\n    });\n    if (clickedOutsideCount === elements.length) {\n      closeTools();\n      removeClickListener();\n    }\n  };\n\n  const removeClickListener = () => {\n    document.removeEventListener('click', outsideClickListener);\n  };\n\n  document.addEventListener('click', outsideClickListener);\n}\n\nfunction initTools(ideo) {\n\n  const triangle = '<span style=\"float: right\">&blacktriangleright;</span>';\n\n  const toolsHtml = `\n    ${style}\n    <div id=\"gear\" style=\"display: none\">${gearIcon}</div>\n    <div id=\"tools\" style=\"display: none\">\n      <ul>\n        <li id=\"download-tool\" class=\"ideo-tool-hover\">Download ${triangle}</li>\n        <li id=\"about-tool\">About</li>\n      </ul>\n    </div>`;\n\n\n  document.querySelector(ideo.selector)\n    .insertAdjacentHTML('beforebegin', toolsHtml);\n\n  handleGearClick(ideo);\n\n  showGearOnIdeogramHover(ideo);\n}\n\nexport {initTools};\n\n","/* eslint-disable no-use-before-define */\n\nexport class ModelAdapter {\n\n  constructor(model) {\n    this._model = model;\n    this._class = 'ModelAdapter';\n  }\n\n  static getInstance(model) {\n    if (model.bands) {\n      return new ModelAdapter(model);\n    } else {\n      return new ModelNoBandsAdapter(model);\n    }\n  }\n\n  getModel() {\n    return this._model;\n  }\n\n  getCssClass() {\n    return '';\n  }\n}\n\nexport class ModelNoBandsAdapter extends ModelAdapter {\n\n  constructor(model) {\n    super(model);\n    this._class = 'ModelNoBandsAdapter';\n  }\n\n  getModel() {\n    this._model.bands = [];\n\n    const isMT = this._model.name === 'MT'; // Is mitochondrial chromosome\n    const width = this._model.width;\n\n    if (width > 1 || isMT) {\n      // Add single band to bands array\n      this._model.bands.push({\n        name: 'q',\n        px: {\n          start: 0,\n          stop: width,\n          width: width\n        },\n        bp: {\n          start: 1,\n          stop: this._model.bpLength ?? this._model.length\n        },\n        iscn: {\n          start: 1,\n          stop: this._model.length\n        }\n      });\n    }\n\n    return this._model;\n  }\n\n  getCssClass() {\n    return 'noBands';\n  }\n\n}\n","import {Ploidy} from './ploidy';\n\nexport class Color {\n\n  constructor(config) {\n    // Ideogram config\n    this._config = config;\n    this._ploidy = new Ploidy(this._config);\n  }\n\n  getArmColor(chrSetIndex, chrIndex, armIndex) {\n    if (this._config.armColors) {\n      return this._config.armColors[armIndex];\n    } else if (this._config.ancestors) {\n      return this._getPolyploidArmColor(chrSetIndex, chrIndex, armIndex);\n    } else {\n      return null;\n    }\n  }\n\n  getBorderColor(chrSetIndex, chrIndex, armIndex) {\n    const config = this._config;\n    const color = config.chrBorderColor ? config.chrBorderColor : '#000';\n    if (chrIndex < config.ploidy) {\n      return color;\n    } else if (this._ploidy.exists(chrSetIndex, chrIndex, armIndex)) {\n      return color;\n    } else {\n      return '#fff';\n    }\n  }\n\n  getFillColor() {\n    const config = this._config;\n    if (!config.chrFillColor) return '#AAA';\n    const color = config.chrFillColor;\n    if (typeof color === 'string') {\n      return {arm: color, centromere: ''};\n    } else {\n      return color;\n    };\n  }\n\n  _getPolyploidArmColor(chrSetIndex, chrIndex, armIndex) {\n    if (!this._ploidy.exists(chrSetIndex, chrIndex, armIndex)) {\n      return 'transparent';\n    } else {\n      var ancestor =\n        this._ploidy.getAncestor(chrSetIndex, chrIndex, armIndex);\n      return this._config.ancestors[ancestor];\n    }\n  }\n\n}\n","export class Range {\n\n  /**\n  * Chromosome range.\n  * @public\n  * @class\n  * @param {Object} data - range data.\n  * @param {Integer} data.chr - chromosome index.\n  * @param {Integer[]} [data.ploidy] - array which controls on which\n  *                                    chromosomes range should appear in case\n  *                                    of ploidy.\n  * @param {Integer} data.start - range start.\n  * @param {Integer} data.stop - range end.\n  * @param {String} data.color - range color.\n  */\n  constructor(data) {\n    this._data = data;\n    this.start = data.start;\n    this.stop = data.stop;\n    this.length = this.stop - this.start;\n  }\n\n  getColor(chrIndex) {\n    if (!('ploidy' in this._data)) {\n      return this._getColor(chrIndex);\n    } else if ('ploidy' in this._data && this._data.ploidy[chrIndex]) {\n      return this._getColor(chrIndex);\n    } else {\n      return 'transparent';\n    }\n  }\n\n  _getColor(chrIndex) {\n    if (Array.isArray(this._data.color)) {\n      return this._data.color[chrIndex];\n    } else {\n      return this._data.color;\n    }\n  }\n\n}\n","/* eslint-disable no-use-before-define */\nimport {Color} from './../color';\nimport {Range} from './../range';\n\nexport class Chromosome {\n\n  constructor(adapter, config, ideo) {\n    this._adapter = adapter;\n    this._model = this._adapter.getModel();\n    this._config = config;\n    this._ideo = ideo;\n    this._color = new Color(this._config);\n    this._bumpCoefficient = 5;\n  }\n\n  /**\n   * Factory method\n   */\n  static getInstance(adapter, config, ideo) {\n    const centromerePosition = adapter.getModel().centromerePosition;\n    if (centromerePosition === 'telocentric-p') {\n      return new TelocentricPChromosome(adapter, config, ideo);\n    } else if (centromerePosition === 'telocentric-q') {\n      return new TelocentricQChromosome(adapter, config, ideo);\n    } else {\n      return new MetacentricChromosome(adapter, config, ideo);\n    }\n  }\n\n  _addPArmShape(clipPath, isPArmRendered) {\n    if (isPArmRendered) {\n      return clipPath.concat(this._getPArmShape());\n    } else {\n      return clipPath;\n    }\n  }\n\n  _addQArmShape(clipPath, isQArmRendered) {\n    if (isQArmRendered) {\n      return clipPath.concat(this._getQArmShape());\n    } else {\n      return clipPath;\n    }\n  }\n\n  /**\n   * Append bands container and apply clip-path to it\n   */\n  render(container, chrSetIndex, chrIndex) {\n\n    var self, isPArmRendered, isQArmRendered, clipPath, opacity, fill,\n      isFullyBanded;\n\n    self = this;\n\n    container = container.append('g')\n      .attr('class', 'bands')\n      .attr('clip-path',\n        'url(#' + this._model.id + '-chromosome-set-clippath)'\n      );\n\n    // Render chromosome arms\n    isPArmRendered = this._renderArm(container, chrSetIndex, chrIndex, 'p');\n    isQArmRendered = this._renderArm(container, chrSetIndex, chrIndex, 'q');\n\n    // Render range set\n    this._renderRangeSet(container, chrSetIndex, chrIndex);\n\n    // Push arms shape string into clipPath array\n    clipPath = [];\n    clipPath = this._addPArmShape(clipPath, isPArmRendered);\n    clipPath = this._addQArmShape(clipPath, isQArmRendered);\n\n    opacity = '0';\n    fill = '';\n    isFullyBanded = this.isFullyBanded();\n    if (\n      'ancestors' in this._ideo.config &&\n      !('rangeSet' in this._ideo.config)\n    ) {\n      // E.g. diploid human genome (with translucent overlay)\n      fill = self._color.getArmColor(chrSetIndex, chrIndex, 0);\n      if (isFullyBanded) {\n        opacity = '0.5';\n      }\n    } else if (isFullyBanded) {\n      // E.g. mouse reference genome\n      opacity = null;\n      fill = 'transparent';\n    } else if (!('ancestors' in this._ideo.config)) {\n      // E.g. chimpanzee assembly Pan_tro 3.0\n      opacity = '1';\n    }\n\n    let centromereFill;\n    if (this._ideo.config.chrFillColor) {\n      const fillColor = self._color.getFillColor();\n      fill = fillColor.arm;\n      centromereFill = fillColor.centromere;\n    }\n\n    // Render chromosome border\n    container.append('g')\n      .attr('class', 'chromosome-border')\n      .selectAll('path')\n      .data(clipPath)\n      .enter()\n      .append('path')\n      .attr('fill', fill)\n      .style('fill-opacity', opacity)\n      .style('fill', function(d) {\n        if (d.class === 'acen' && centromereFill) {\n          return centromereFill;\n        }\n      })\n      .attr('stroke', function(d, i) {\n        return self._color.getBorderColor(chrSetIndex, chrIndex, i);\n      })\n      .attr('stroke-width', function(d) {\n        return ('strokeWidth' in d ? d.strokeWidth : 1);\n      })\n      .attr('d', function(d) {\n        return d.path;\n      }).attr('class', function(d) {\n        return d.class;\n      });\n\n    return clipPath;\n  }\n\n  _renderRangeSet(container, chrSetIndex, chrIndex) {\n\n    var self, rangeSet, rangesContainer, ideo;\n\n    if (!('rangeSet' in this._config)) {\n      return;\n    }\n\n    rangeSet = this._config.rangeSet.filter(function(range) {\n      return range.chr - 1 === chrSetIndex;\n    }).map(function(range) {\n      return new Range(range);\n    });\n\n    rangesContainer = container.append('g').attr('class', 'range-set');\n\n    self = this;\n    ideo = self._ideo;\n\n    rangesContainer.selectAll('rect.range')\n      .data(rangeSet)\n      .enter()\n      .append('rect')\n      .attr('class', 'range')\n      .attr('x', function(range) {\n        return ideo.convertBpToPx(self._model, range.start);\n      }).attr('y', 0)\n      .attr('width', function(range) {\n        return ideo.convertBpToPx(self._model, range.length);\n      }).attr('height', this._config.chrWidth)\n      .style('fill', function(range) {\n        return range.getColor(chrIndex);\n      });\n  }\n\n  /**\n   * Get chromosome's shape main values\n   */\n  _getShapeData() {\n\n    var firstQBand, i, lastBand, rightTerminalPosition;\n\n    // First q band from bands sequence\n    for (i = 0; i < this._model.bands.length; i++) {\n      if (this._model.bands[i].name[0] === 'q') {\n        firstQBand = this._model.bands[i];\n        break;\n      }\n    }\n\n    // Chromosome's right position\n    lastBand = this._model.bands.length - 1;\n    rightTerminalPosition = this._model.bands[lastBand].px.stop;\n\n    // Properties description:\n    // x1 - left terminal start position\n    // x2 - centromere position\n    // x3 - right terminal end position\n    // w - chromosome width\n    // b - bump size\n    return {\n      x1: 0,\n      x2: firstQBand ? firstQBand.px.start : rightTerminalPosition,\n      x3: rightTerminalPosition,\n      w: this._config.chrWidth,\n      b: this._config.chrWidth / this._bumpCoefficient\n    };\n  }\n\n  _getPArmShape() {\n    var d = this._getShapeData(),\n      x = d.x2 - d.b;\n\n    if (this.isFullyBanded() || 'ancestors' in this._ideo.config) {\n      // Encountered when chromosome has any of:\n      //  - One placeholder \"band\", e.g. pig genome GCF_000003025.5\n      //  - Many (> 2) bands, e.g. human reference genome\n      //  - Ancestor colors in ploidy configuration, as in ploidy-basic.html\n      return {\n        class: '',\n        path:\n          'M' + d.b + ',0 ' +\n          'L' + x + ',0 ' +\n          'Q' + (d.x2 + d.b) + ',' + (d.w / 2) + ',' + x + ',' + d.w + ' ' +\n          'L' + d.b + ',' + d.w + ' ' +\n          'Q-' + d.b + ',' + (d.w / 2) + ',' + d.b + ',0'\n      };\n    } else {\n      // e.g. chimpanzee assembly Pan_tro 3.0\n      return [{\n        class: '',\n        path:\n          'M' + d.b + ',0 ' +\n          'L' + (x - 2) + ',0 ' +\n          'L' + (x - 2) + ',' + d.w + ' ' +\n          'L' + d.b + ',' + d.w + ' ' +\n          'Q-' + d.b + ',' + (d.w / 2) + ',' + d.b + ',0'\n      }, {\n        class: 'acen',\n        path:\n          'M' + x + ',0 ' +\n          'Q' + (d.x2 + d.b) + ',' + (d.w / 2) + ',' + x + ',' + d.w + ' ' +\n          'L' + x + ',' + d.w + ' ' +\n          'L' + (x - 2) + ',' + d.w + ' ' +\n          'L' + (x - 2) + ',0'\n      }];\n    }\n  }\n\n  _getQArmShape() {\n    var d = this._getShapeData(),\n      x = d.x3 - d.b,\n      x2b = d.x2 + d.b;\n\n    if (this.isFullyBanded() || 'ancestors' in this._ideo.config) {\n      return {\n        class: '',\n        path:\n          'M' + x2b + ',0 ' +\n          'L' + x + ',0 ' +\n          'Q' + (d.x3 + d.b) + ',' + (d.w / 2) + ',' + x + ',' + d.w + ' ' +\n          'L' + x2b + ',' + d.w + ' ' +\n          'Q' + (d.x2 - d.b) + ',' + (d.w / 2) + ',' + x2b + ',0'\n      };\n    } else {\n      // e.g. chimpanzee assembly Pan_tro 3.0\n      return [{\n        path:\n          'M' + x2b + ',0 ' +\n          'L' + x + ',0 ' +\n          'Q' + (d.x3 + d.b) + ',' + (d.w / 2) + ',' + x + ',' + d.w + ' ' +\n          'L' + x2b + ',' + d.w + ' ' +\n          'L' + x2b + ',0'\n      }, {\n        class: 'acen',\n        path:\n          'M' + x2b + ',0' +\n          'Q' + (d.x2 - d.b) + ',' + (d.w / 2) + ',' + x2b + ',' + d.w + ' ' +\n          'L' + x2b + ',' + d.w +\n          'L' + (x2b + 2) + ',' + d.w +\n          'L' + (x2b + 2) + ',0'\n      }];\n    }\n  }\n\n  isFullyBanded() {\n    return (\n      this._model.bands &&\n      (this._model.bands.length !== 2 || this._model.bands[0].name[0] === 'q')\n    );\n  }\n\n  /**\n   * Render arm bands\n   */\n  _renderBands(container, chrSetIndex, chrIndex, bands, arm) {\n\n    var self, armIndex, fill;\n\n    self = this;\n    armIndex = arm === 'p' ? 0 : 1;\n    fill = '';\n\n    if ('ancestors' in self._ideo.config && !(self.isFullyBanded())) {\n      fill = self._color.getArmColor(chrSetIndex, chrIndex, armIndex);\n    }\n\n    container.selectAll('path.band.' + arm)\n      .data(bands)\n      .enter()\n      .append('path')\n      .attr('id', function(d) {\n        return self._model.id + '-' + d.name.replace('.', '-');\n      })\n      .attr('class', function(d) {\n        return 'band ' + arm + '-band ' + d.stain;\n      })\n      .attr('d', function(d) {\n        var start, length;\n\n        start = self._ideo.round(d.px.start);\n        length = self._ideo.round(d.px.width);\n\n        return 'M ' + start + ', 0' +\n              'l ' + length + ' 0 ' +\n              'l 0 ' + self._config.chrWidth + ' ' +\n              'l -' + length + ' 0 z';\n      })\n      .style('fill', fill);\n  }\n\n  /**\n   * Render a chromosome arm.\n   * Returns boolean indicating if any bands were rendered.\n   */\n  _renderArm(container, chrSetIndex, chrIndex, arm) {\n    var bands = this._model.bands.filter(function(band) {\n      return band.name[0] === arm;\n    });\n\n    this._renderBands(container, chrSetIndex, chrIndex, bands, arm);\n\n    return Boolean(bands.length);\n  }\n}\n\nexport class MetacentricChromosome extends Chromosome {\n\n  constructor(model, config, ideo) {\n    super(model, config, ideo);\n    this._class = 'MetacentricChromosome';\n  }\n}\n\nexport class TelocentricPChromosome extends Chromosome {\n\n  constructor(model, config, ideo) {\n    // alert('p')\n    super(model, config, ideo);\n    this._class = 'TelocentricPChromosome';\n    this._pArmOffset = 3;\n  }\n\n  _addPArmShape(clipPath) {\n    return clipPath.concat(this._getPArmShape());\n  }\n\n  _getPArmShape() {\n    // Properties description:\n    // x1 - left terminal start position\n    // x2 - centromere position\n    // x3 - right terminal end position\n    // w - chromosome width\n    // b - bump size\n    var d = this._getShapeData();\n    d.o = this._pArmOffset;\n\n    return [{\n      class: 'acen',\n      path: 'M' + (d.x2 + 2) + ',1' +\n      'L' + (d.x2 + d.o + 3.25) + ',1 ' +\n      'L' + (d.x2 + d.o + 3.25) + ',' + (d.w - 1) + ' ' +\n      'L' + (d.x2 + 2) + ',' + (d.w - 1)\n    }, {\n      class: 'gpos66',\n      path: 'M' + (d.x2 - d.o + 5) + ',0' +\n      'L' + (d.x2 - d.o + 3) + ',0 ' +\n      'L' + (d.x2 - d.o + 3) + ',' + d.w + ' ' +\n      'L' + (d.x2 - d.o + 5) + ',' + d.w,\n      strokeWidth: 0.5\n    }];\n  }\n\n  _getQArmShape() {\n    // Properties description:\n    // x1 - left terminal start position\n    // x2 - centromere position\n    // x3 - right terminal end position\n    // w - chromosome width\n    // b - bump size\n    var d = this._getShapeData(),\n      x = d.x3 - d.b,\n      o = this._pArmOffset + 3;\n\n    return {\n      class: '',\n      path:\n      'M' + (d.x2 + o) + ',0 ' +\n      'L' + x + ',0 ' +\n      'Q' + (d.x3 + d.b) + ',' + (d.w / 2) + ',' + x + ',' + d.w + ' ' +\n      'L' + (d.x2 + o) + ',' + d.w\n    };\n  }\n}\n\nexport class TelocentricQChromosome extends Chromosome {\n\n  constructor(model, config, ideo) {\n    // alert('q')\n    super(model, config, ideo);\n    this._class = 'TelocentricQChromosome';\n    this._qArmOffset = 3;\n  }\n\n  _getPArmShape() {\n    // Properties description:\n    // x1 - left terminal start position\n    // x2 - centromere position\n    // x3 - right terminal end position\n    // w - chromosome width\n    // b - bump size\n\n    var d = this._getShapeData(),\n      x = d.x3 - d.b,\n      o = this._qArmOffset;\n\n    return {\n      class: '',\n      path:\n      // 'M1,0, ' +\n      'M' + (d.x2 + o) + ',0 ' +\n      'L' + (x + o) + ',0 ' +\n      'L' + (x + o) + ',' + d.w + ' ' +\n      'L' + d.b + ',' + d.w + ' ' +\n      'Q-' + d.b + ',' + (d.w / 2) + ',' + d.b + ',0'\n    };\n  }\n\n  _addQArmShape(clipPath) {\n    return clipPath.concat(this._getQArmShape());\n  }\n\n  _getQArmShape() {\n    // Properties description:\n    // x1 - left terminal start position\n    // x2 - centromere position\n    // x3 - right terminal end position\n    // w - chromosome width\n    // b - bump size\n    var d = this._getShapeData();\n    d.o = this._qArmOffset;\n\n    return [{\n      class: 'acen',\n      path: 'M' + (d.x2 + 2) + ',1 ' +\n      'L' + (d.x2 + d.o + 3.25) + ',1 ' +\n      'L' + (d.x2 + d.o + 3.25) + ',' + (d.w - 1) + ' ' +\n      'L' + (d.x2 + 2) + ',' + (d.w - 1)\n    }, {\n      class: 'gpos66',\n      path: 'M' + (d.x2 + d.o + 5) + ',0 ' +\n      'L' + (d.x2 + d.o + 3) + ',0 ' +\n      'L' + (d.x2 + d.o + 3) + ',' + d.w + ' ' +\n      'L' + (d.x2 + d.o + 5) + ',' + d.w,\n      strokeWidth: 0.5\n    }];\n  }\n}\n","import {d3} from '../lib';\nimport {initTools} from '../tools/tools';\nimport {ModelAdapter} from '../model-adapter';\nimport {Chromosome} from './chromosome';\n\n/**\n * Adds a copy of a chromosome (i.e. a homologous chromosome, homolog) to DOM\n *\n * @param chrModel\n * @param chrIndex\n * @param homologIndex\n * @param container\n */\nfunction appendHomolog(chrModel, chrIndex, homologIndex, container) {\n\n  var homologOffset, chromosome, shape, defs, adapter;\n\n  defs = d3.select(this.selector + ' defs');\n  // Get chromosome model adapter class\n  adapter = ModelAdapter.getInstance(chrModel);\n\n  // How far this copy of the chromosome is from another\n  homologOffset = homologIndex * this.config.chrMargin;\n\n  // Append chromosome's container\n  chromosome = container\n    .append('g')\n    .attr('id', chrModel.id)\n    .attr('class', 'chromosome ' + adapter.getCssClass())\n    .attr('transform', 'translate(0, ' + homologOffset + ')');\n\n  // Render chromosome\n  shape = Chromosome.getInstance(adapter, this.config, this)\n    .render(chromosome, chrIndex, homologIndex);\n\n  d3.select('#' + chrModel.id + '-chromosome-set-clippath').remove();\n\n  defs.append('clipPath')\n    .attr('id', chrModel.id + '-chromosome-set-clippath')\n    .selectAll('path')\n    .data(shape)\n    .enter()\n    .append('path')\n    .attr('d', function(d) {return d.path;})\n    .attr('class', function(d) {return d.class;});\n\n\n  if (chrModel.width < 1) {\n    d3.select('#' + chrModel.id + ' .bands').style('opacity', 0);\n  }\n}\n\n/**\n * Renders all the bands and outlining boundaries of a chromosome.\n */\nfunction drawChromosome(chrModel) {\n  var chrIndex, container, numChrsInSet, transform, homologIndex,\n    chrSetSelector;\n\n  chrIndex = chrModel.chrIndex;\n\n  transform = this._layout.getChromosomeSetTranslate(chrIndex);\n\n  chrSetSelector = this.selector + ' #' + chrModel.id + '-chromosome-set';\n\n  d3.selectAll(chrSetSelector + ' g').remove();\n\n  container = d3.select(chrSetSelector);\n\n  if (container.nodes().length === 0) {\n    // Append chromosome set container\n    container = d3.select(this.selector)\n      .append('g')\n      .attr('class', 'chromosome-set')\n      .attr('transform', transform)\n      .attr('id', chrModel.id + '-chromosome-set');\n  }\n\n  if (\n    'sex' in this.config &&\n    this.config.ploidy === 2 &&\n    this.sexChromosomes.index === chrIndex\n  ) {\n    this.drawSexChromosomes(container, chrIndex);\n    return;\n  }\n\n  numChrsInSet = 1;\n  if (this.config.ploidy > 1) {\n    numChrsInSet = this._ploidy.getChromosomesNumber(chrIndex);\n  }\n\n  for (homologIndex = 0; homologIndex < numChrsInSet; homologIndex++) {\n    this.appendHomolog(chrModel, chrIndex, homologIndex, container);\n  }\n}\n\n/**\n * Rotates a chromosome 90 degrees and shows or hides all other chromosomes\n * Useful for focusing or defocusing a particular chromosome\n */\nfunction rotateAndToggleDisplay(chrElement) {\n  var chrName, chrModel, chrIndex;\n\n  this.unhighlight();\n\n  // Do nothing if taxid not defined. But it should be defined.\n  // To fix that bug we should have a way to find chromosome set number.\n  if (!this.config.taxid) return;\n\n  chrName = chrElement.id.split('-')[0].replace('chr', '');\n  chrModel = this.chromosomes[this.config.taxid][chrName];\n  chrIndex = chrModel.chrIndex;\n\n  this._layout.rotate(chrIndex, chrIndex, chrElement);\n}\n\nfunction setOverflowScroll() {\n  var ideo, config, ideoWidth, ideoInnerWrap, ideoMiddleWrap, ideoSvg,\n    ploidy, ploidyPad;\n\n  ideo = this;\n  config = ideo.config;\n\n  ideoSvg = d3.select(config.container + ' svg#_ideogram');\n  ideoInnerWrap = d3.select(config.container + ' #_ideogramInnerWrap');\n  ideoMiddleWrap = d3.select(config.container + ' #_ideogramMiddleWrap');\n\n  ploidy = config.ploidy;\n  if (ploidy === 1) {\n    ploidyPad = ploidy;\n  } else {\n    ploidyPad = ploidy * 1.12;\n  }\n\n  let annotHeight = 0;\n  if ('annotationsLayout' in config) {\n    annotHeight = config.annotationHeight * config.numAnnotTracks;\n  }\n\n  if (\n    config.orientation === 'vertical' &&\n    config.perspective !== 'comparative' &&\n    config.geometry !== 'collinear'\n  ) {\n    ideoWidth =\n      (ideo.numChromosomes) *\n      (config.chrWidth + config.chrMargin + annotHeight);\n  } else {\n    return;\n  }\n\n  if (config.annotationsLayout === 'heatmap-2d') {\n    return;\n  }\n\n  ideoWidth = Math.ceil(ideoWidth * ploidyPad / config.rows);\n  if (ideo._layout._class === 'SmallLayout') ideoWidth += 100;\n\n  ideoWidth += 35; // Account for settings gear\n\n  // Ensures absolutely-positioned elements, e.g. heatmap overlaps, display\n  // properly if ideogram container also has position: absolute\n  ideoMiddleWrap.style('height', ideo._layout.getHeight() + 'px');\n\n  ideoInnerWrap\n    .style('max-width', ideoWidth + 'px')\n    .style('overflow-x', 'scroll')\n    .style('position', 'absolute');\n\n  ideoSvg.style('min-width', (ideoWidth - 5) + 'px');\n\n  if (ideo.config.showTools) {\n    initTools(ideo);\n  }\n}\n\nexport {\n  appendHomolog, drawChromosome, rotateAndToggleDisplay, setOverflowScroll\n};\n","import {d3} from '../lib';\n\nfunction getChrSetLabelLines(d, i, ideo) {\n  var lines;\n  if (d.name.indexOf(' ') === -1) {\n    lines = [d.name];\n  } else {\n    lines = d.name.match(/^(.*)\\s+([^\\s]+)$/).slice(1).reverse();\n  }\n\n  if (\n    'sex' in ideo.config &&\n    ideo.config.ploidy === 2 &&\n    i === ideo.sexChromosomes.index\n  ) {\n    if (ideo.config.sex === 'male') {\n      lines = ['XY'];\n    } else {\n      lines = ['XX'];\n    }\n  }\n\n  return lines;\n}\n\nfunction renderChromosomeSetLabel(d, i, textElement, ideo) {\n  // Get label lines\n  var lines = getChrSetLabelLines(d, i, ideo);\n\n  // Render label lines\n  d3.select(textElement).selectAll('tspan')\n    .data(lines)\n    .enter()\n    .append('tspan')\n    .attr('dy', function(d, i) {\n      return i * -1.2 + 'em';\n    })\n    .attr('x', ideo._layout.getChromosomeSetLabelXPosition())\n    .attr('class', function(a, i) {\n      var fullLabels = ideo.config.fullChromosomeLabels;\n      return i === 1 && fullLabels ? 'italic' : null;\n    })\n    .text(String);\n}\n\nfunction appendChromosomeSetLabels(ideo) {\n  var layout = ideo._layout;\n\n  d3.selectAll(ideo.selector + ' .chromosome-set')\n    .insert('text', ':first-child')\n    .data(ideo.chromosomesArray)\n    .attr('class', layout.getChromosomeLabelClass())\n    .attr('transform', layout.getChromosomeSetLabelTranslate())\n    .attr('x', layout.getChromosomeSetLabelXPosition())\n    .attr('y', function(d, i) {\n      return layout.getChromosomeSetLabelYPosition(i);\n    })\n    .attr('text-anchor', layout.getChromosomeSetLabelAnchor())\n    .each(function(d, i) {\n      renderChromosomeSetLabel(d, i, this, ideo);\n    });\n}\n\nfunction appendChromosomeLabels(ideo) {\n  var layout = ideo._layout;\n\n  d3.selectAll(ideo.selector + ' .chromosome-set')\n    .each(function(a, chrSetIndex) {\n      d3.select(this).selectAll('.chromosome')\n        .append('text')\n        .attr('class', 'chrLabel')\n        .attr('transform', layout.getChromosomeSetLabelTranslate())\n        .attr('x', function(d, i) {\n          return layout.getChromosomeLabelXPosition(i);\n        })\n        .attr('y', function(d, i) {\n          return layout.getChromosomeLabelYPosition(i);\n        })\n        .text(function(d, chrIndex) {\n          return ideo._ploidy.getAncestor(chrSetIndex, chrIndex);\n        })\n        .attr('text-anchor', 'middle');\n    });\n}\n\n/**\n * Draws labels for each chromosome, e.g. \"1\", \"2\", \"X\".\n * If ideogram configuration has 'fullChromosomeLabels: True',\n * then labels includes name of taxon, which can help when\n * depicting orthologs.\n */\nfunction drawChromosomeLabels() {\n  var ideo = this;\n  appendChromosomeSetLabels(ideo);\n  appendChromosomeLabels(ideo);\n}\n\nfunction getLabelPositionAttrs(scale) {\n  var x, y, scaleSvg;\n\n  if (\n    typeof (scale) !== 'undefined' &&\n    scale.hasOwnProperty('x') &&\n    !(scale.x === 1 && scale.y === 1)\n  ) {\n    scaleSvg = 'scale(' + scale.x + ',' + scale.y + ')';\n    x = -6;\n    y = (scale === '' ? -16 : -14);\n  } else {\n    x = -8;\n    y = -16;\n    scale = {x: 1, y: 1};\n    scaleSvg = '';\n  }\n\n  return {x: x, y: y, scaleSvg: scaleSvg, scale: scale};\n}\n\nfunction updateChrIndex(chrIndex, config) {\n  if (config.numAnnotTracks > 1 || config.orientation === '') chrIndex -= 1;\n  return chrIndex;\n}\n\nfunction rotateVerticalChromosomeLabels(chr, chrIndex, labelPosAttrs, ideo) {\n  var chrMargin2, chrMargin, y,\n    config = ideo.config;\n\n  chrIndex = updateChrIndex(chrIndex, config);\n\n  chrMargin2 = -4;\n  if (config.showBandLabels === true) {\n    chrMargin2 = config.chrMargin + config.chrWidth + 26;\n  }\n\n  chrMargin = config.chrMargin * chrIndex;\n  if (config.numAnnotTracks > 1 === false) chrMargin += 1;\n\n  y = chrMargin + chrMargin2;\n\n  chr.selectAll('text.chrLabel')\n    .attr('transform', labelPosAttrs.scaleSvg)\n    .selectAll('tspan')\n    .attr('x', labelPosAttrs.x)\n    .attr('y', y);\n}\n\nfunction rotateHorizontalChromosomeLabels(chr, chrIndex, labelPosAttrs, ideo) {\n  var chrMargin, chrMargin2, tracksHeight, x,\n    config = ideo.config;\n\n  chrMargin2 = -config.chrWidth - 2;\n  if (config.showBandLabels === true) chrMargin2 = config.chrMargin + 8;\n\n  tracksHeight = config.annotTracksHeight;\n  if (config.annotationsLayout !== 'overlay') tracksHeight *= 2;\n\n  chrMargin = config.chrMargin * chrIndex;\n  x = -(chrMargin + chrMargin2) + 3 + tracksHeight;\n  x /= labelPosAttrs.scale.x;\n\n  chr.selectAll('text.chrLabel')\n    .attr('transform', 'rotate(-90)' + labelPosAttrs.scaleSvg)\n    .selectAll('tspan')\n    .attr('x', x)\n    .attr('y', labelPosAttrs.y);\n}\n\n/**\n * Rotates chromosome labels by 90 degrees, e.g. upon clicking a chromosome.\n */\nfunction rotateChromosomeLabels(chr, chrIndex, orientation, scale) {\n  var labelPosAttrs,\n    ideo = this;\n\n  chrIndex -= 1;\n\n  labelPosAttrs = getLabelPositionAttrs(scale);\n\n  if (orientation === 'vertical' || orientation === '') {\n    rotateVerticalChromosomeLabels(chr, chrIndex, labelPosAttrs, ideo);\n  } else {\n    rotateHorizontalChromosomeLabels(chr, chrIndex, labelPosAttrs, ideo);\n  }\n}\n\nexport {drawChromosomeLabels, rotateChromosomeLabels};\n","/** Get time in milliseconds between a start time (t0) and now */\nfunction timeDiff(t0) {\n  return Math.round(performance.now() - t0);\n}\n\n/** Initialize performance analysis settings */\nfunction initAnalyzeRelatedGenes(ideo) {\n  ideo.time = {\n    rg: { // times for related genes\n      t0: performance.now()\n    }\n  };\n  if ('_didRelatedGenesFirstPlot' in ideo) {\n    delete ideo._didRelatedGenesFirstPlot;\n  }\n}\n\nfunction getRelatedGenesByType() {\n  const ideo = this;\n  const relatedGenes = ideo.annotDescriptions.annots;\n\n  const related = Object.values(relatedGenes).slice();\n\n  const paralogous = related.filter(r => {\n    return r.type && r.type.includes('paralogous');\n  });\n  const interacting = related.filter(r => {\n    return r.type && r.type.includes('interacting gene');\n  });\n  const searched = Object.entries(relatedGenes).filter(entry => {\n    return entry[1].type && entry[1].type.includes('searched gene');\n  })[0][0];\n\n  return {related, paralogous, interacting, searched};\n}\n\nfunction getRelatedGenesTooltipAnalytics(annot) {\n  const ideo = this;\n\n  const timeSincePrevTooltip = performance.now() - ideo.time.prevTooltipOff;\n  const prevAnnotDomId = ideo.time.prevTooltipAnnotDomId;\n\n  if (timeSincePrevTooltip < 300 && annot.domId === prevAnnotDomId) {\n    return null;\n  }\n\n  const tooltipGene = annot.name;\n\n  // e.g. \"interacting gene\" -> \"interacting\"\n  const tooltipRelatedType =\n    ideo.annotDescriptions.annots[annot.name].type.split(' ')[0];\n\n  const countsByType = getCountsByType(ideo);\n\n  const analytics = Object.assign(\n    {tooltipGene, tooltipRelatedType}, countsByType\n  );\n\n  return analytics;\n}\n\n/** Compute granular related genes plotting analytics */\nfunction analyzePlotTimes(type, ideo) {\n  // Paralogs and interacting genes:\n  // http://localhost:8080/examples/vanilla/related-genes?q=RAD51\n  //\n  // No paralogs:\n  // http://localhost:8080/examples/vanilla/related-genes?q=BRCA1&org=mus-musculus\n  //\n  // No interacting genes:\n  // http://localhost:8080/examples/vanilla/related-genes?q=DMC1\n  //\n  // No paralogs, no interacting genes:\n  // http://localhost:8080/examples/vanilla/related-genes?q=BRCA1&org=macaca-mulatta\n\n  if (type === 'pathway') {\n    return;\n  }\n  const otherTypes = {\n    paralogous: 'interacting',\n    interacting: 'paralogous'\n  };\n  const related = ideo.getRelatedGenesByType();\n  const otherType = otherTypes[type];\n  const numThisRelated = related[type].length;\n  const numOtherRelated = related[otherType] ? related[otherType].length : 0;\n\n  if (!ideo._didRelatedGenesFirstPlot) {\n    // 1st of 2 attempted plot logs\n    ideo._didRelatedGenesFirstPlot = true;\n\n    ideo.time.rg.totalFirstPlot = timeDiff(ideo.time.rg.t0);\n\n    if (numThisRelated > 0) {\n      ideo.time.rg.timestampFirstPlot = performance.now();\n      ideo._relatedGenesFirstPlotType = type;\n    }\n  } else {\n    // 2nd of 2 attempted plot logs\n    if (numThisRelated > 0 && numOtherRelated > 0) {\n      // Paralogs and interacting genes were found, e.g. human RAD51\n      const timestampFirstPlot = ideo.time.rg.timestampFirstPlot;\n      ideo.time.rg.totalLastPlotDiff = timeDiff(timestampFirstPlot);\n    } else if (numThisRelated > 0 && numOtherRelated === 0) {\n      // Other attempt did not plot, and this did, so log this as 1st\n      // Often seen when no interacting genes found, e.g. human DMC1\n      ideo.time.rg.timestampFirstPlot = performance.now();\n      ideo.time.rg.totalFirstPlot = timeDiff(ideo.time.rg.t0);\n      ideo._relatedGenesFirstPlotType = type;\n      ideo.time.rg.totalLastPlotDiff = 0;\n\n    } else if (numThisRelated === 0 && numOtherRelated > 0) {\n      // This attempt did not plot, the other did, so log 1st plot as also last\n      // Often seen when no paralogs found, e.g. mouse BRCA1\n      ideo.time.rg.totalLastPlotDiff = 0;\n    } else {\n      // No related genes found, so note only the searched gene is plotted\n      // Example: Macaca mulatta BRCA1\n      ideo._relatedGenesFirstPlotType = 'searched';\n      ideo.time.rg.totalLastPlotDiff = 0;\n    }\n  }\n}\n\nfunction getCountsByType(ideo) {\n  const related = ideo.getRelatedGenesByType();\n\n  const numRelatedGenes = related['related'].length;\n  const numParalogs = related['paralogous'].length;\n  const numInteractingGenes = related['interacting'].length;\n  const searchedGene = related['searched'];\n\n  return {\n    numRelatedGenes, numParalogs, numInteractingGenes, searchedGene\n  };\n}\n\n/** Summarizes number and kind of related genes, performance, etc. */\nfunction analyzeRelatedGenes(ideo) {\n\n  const countsByType = getCountsByType(ideo);\n\n  const timeTotal = ideo.time.rg.total;\n  const timeTotalFirstPlot = ideo.time.rg.totalFirstPlot;\n  const timeTotalLastPlotDiff = ideo.time.rg.totalLastPlotDiff;\n  const timeParalogs = ideo.time.rg.paralogs;\n  const timeInteractingGenes = ideo.time.rg.interactions;\n  const timeSearchedGene = ideo.time.rg.searchedGene;\n  const firstPlotType = ideo._relatedGenesFirstPlotType;\n\n  const analytics = Object.assign({\n    firstPlotType,\n    timeTotal, timeTotalFirstPlot, timeTotalLastPlotDiff,\n    timeSearchedGene, timeInteractingGenes, timeParalogs\n  }, countsByType);\n\n  ideo.relatedGenesAnalytics = analytics;\n}\n\nexport {\n  initAnalyzeRelatedGenes, analyzePlotTimes, analyzeRelatedGenes, timeDiff,\n  getRelatedGenesByType, getRelatedGenesTooltipAnalytics\n};\n","/**\n * @fileoverview Colors for protein features, e.g. domains, families, and sites\n *\n * The color design is intended to visually distinguish protein features, so\n * that patterns can be recognized among interacting and paralogous genes.\n * Colors for each domain were manually assigned, in an iterative process of\n * browsing gene leads ideogram and setting colors per that intent.  Color\n * sometimes overlaps with function, and sometimes not function but moreso\n * visually distinction from other protein features in a given gene leads view.\n */\n\n// Default\nconst grey = '#BBB';\nconst greyLines = '#666';\n\nconst darkGrey = '#888';\nconst darkGreyLine = '#AAA';\n\nconst red = '#F00';\nconst redLines = '#D00';\nconst magenta = '#922D5E';\nconst magentaLines = '#D26D9E';\nconst faintRed = '#CAA';\nconst faintRedLines = '#866';\nconst pink = '#FFC0CB';\nconst pinkLine = '#CF909B';\n\nconst blue = '#99D';\nconst blueLines = '#22C';\nconst lightBlue = '#CCF';\nconst lightBlueLine = '#33D';\nconst deepBlue = '#55A';\nconst deepBlueLines = '#AAF';\n\nconst green = '#7D7';\nconst greenLines = '#5B5';\nconst seafoam = '#93E9BE';\nconst seafoamLines = '#53AC7E';\n\n// Purples\nconst darkPurple = '#51087E';\nconst darkPurpleLine = '#8138AE';\nconst purple = '#880ED4';\nconst purpleLine = '#5800A4';\nconst purple2 = '#A020F0';\nconst purple2Line = '#7000C0';\nconst lightPurple = '#B24BF3';\nconst lightPurpleLine = '#921BC3';\nconst veryLightPurple = '#D7A1F9';\nconst veryLightPurpleLine = '#A771C9';\n\nconst brown = '#964B00';\nconst brownLine = '#C67B30';\nconst lightBrown = '#DACDBA';\nconst lightBrownLine = '#BAAB9A';\nconst orange = '#FFA500';\nconst orangeLines = '#DD8000';\n\nexport function getColors(domainType) {\n  if (domainType.includes('conserved site')) {\n    // https://www.google.com/search?q=pymol+conserved+site+color&tbm=isch\n    return [magenta, magentaLines];\n  } else if (\n    // Enzymatic sites\n    domainType.includes('active site') ||\n    domainType.includes('hydroxylation site') ||\n    domainType.includes('Lipid transport')\n  ) {\n    return [red, redLines];\n  } else if (\n    // Enzymatic domains, C-terminal regions, and misnellaneou\n    domainType.includes('catalytic domain') ||\n    domainType.includes('kinase domain') ||\n    domainType === 'PIK-related kinase, FAT' ||\n    domainType.includes('trypsin domain') ||\n    domainType === 'Transforming growth factor-beta, C-terminal' ||\n    domainType === 'Cyclin, C-terminal domain' ||\n    domainType.includes('OB C-terminal domain') ||\n    domainType === 'Cationic amino acid transporter, C-terminal' ||\n    domainType === 'High mobility group box domain' ||\n    domainType.includes('Peptidase M2') ||\n    domainType.includes('CUB domain') ||\n    domainType === 'C-5 cytosine methyltransferase' ||\n    domainType.includes('(G-protein), alpha subunit') ||\n    domainType === 'SCAN domain' ||\n    domainType === 'Apolipoprotein A/E' ||\n    domainType.includes('SMAD domain') ||\n    domainType === 'PLAC' ||\n    domainType.endsWith('tripeptidyl peptidase II') ||\n    domainType === 'Prohormone convertase enzyme'\n  ) {\n    return [faintRed, faintRedLines];\n  } else if (\n    // Binding sites, and smaller binding regions\n    domainType.includes('binding site') ||\n    domainType === 'EF-hand domain' ||\n    domainType === 'Zinc finger, nuclear hormone receptor-type' ||\n    domainType.includes('Serpin domain') ||\n    domainType === 'Peptidase C14,  p20 domain' ||\n    domainType === 'PWWP domain' ||\n    domainType === 'GPCR, rhodopsin-like, 7TM' ||\n    domainType === 'Peptidoglycan binding-like' ||\n    domainType === 'MAD homology 1, Dwarfin-type'\n  ) {\n    return [blue, blueLines];\n  } else if (\n    domainType.includes('dehydrogenase, molybdopterin binding') ||\n    domainType === 'Zinc finger CCHC HIVEP-type' ||\n    domainType === 'Cyclin, N-terminal' ||\n    domainType === 'MAD homology, MH1' ||\n    domainType === 'Sodium ion transport-associated'\n  ) {\n    return [lightBlue, lightBlueLine];\n  } else if (\n    // Larger binding regions and miscellaneous\n    domainType.includes('binding domain') ||\n    domainType.includes('zinc-binding') ||\n    domainType.includes('DNA-binding') ||\n    domainType === 'G protein-coupled receptor, rhodopsin-like' ||\n    domainType.includes('Homeobox domain') ||\n    domainType.includes('Ion transport domain') ||\n    domainType.includes('BRCT domain') ||\n    domainType.includes('transactication domain') ||\n    domainType.includes('EF-hand') ||\n    domainType === 'Laminin G domain' ||\n    domainType === 'Peptidase C14, caspase non-catalytic subunit p10' ||\n    domainType === 'ADD domain' ||\n    domainType === 'PDZ domain' ||\n    domainType === 'Krueppel-associated box' ||\n    domainType === 'Ets domain' ||\n    domainType === 'P domain'\n  ) {\n    return [deepBlue, deepBlueLines];\n  } else if (\n    domainType === 'SH2 domain' ||\n    domainType.includes('Furin-like') ||\n    domainType.includes('heparin-binding') ||\n    domainType === 'SRCR domain' ||\n    domainType === 'EGF-like domain' ||\n    domainType.includes('EGF domain') ||\n    domainType === 'Basic leucine zipper domain, Maf-type' ||\n    domainType.includes('Interleukin') && domainType.includes('propeptide') ||\n    domainType === 'Sirtuin family' ||\n    domainType === 'Amino acid/polyamine transporter I' ||\n    domainType === 'Peptidase M10, metallopeptidase' ||\n    domainType === 'Zinc finger C2H2-type'\n  ) {\n    return [green, greenLines];\n  } else if (\n    domainType === 'SH3 domain' ||\n    domainType.includes('copper-binding') ||\n    domainType === 'Sushi/SCR/CCP domain' ||\n    domainType.includes('Receptor L-domain') ||\n    domainType.includes('Coagulation factor 5/8') ||\n    domainType === 'Basic-leucine zipper domain' ||\n    domainType.includes('Interleukin') && domainType.includes('family') ||\n    domainType === 'Sirtuin family, catalytic core domain' ||\n    domainType === 'Amine oxidase' ||\n    domainType.includes('lid domain') ||\n    domainType.includes('prodomain')\n  ) {\n    return [seafoam, seafoamLines];\n  }\n\n  else if (\n    // Immunoglobulin domains are colored in the pink-purple spectrum\n    domainType === 'Immunoglobulin-like domain' ||\n    domainType === 'Major facilitator superfamily domain' ||\n    domainType.includes('interface')\n  ) {\n    return [pink, pinkLine];\n  } else if (\n    domainType === 'Immunoglobulin' ||\n    domainType === 'Calponin homology domain' ||\n    domainType.includes('ATPase') ||\n    domainType.includes('globular domain') ||\n    domainType === 'Mitochondrial substrate/solute carrier' ||\n    domainType === 'Major facilitator,  sugar transporter-like' ||\n    domainType === 'Sodium:neurotransmitter symporter' ||\n    domainType === 'Fibronectin type III'\n  ) {\n    return [veryLightPurple, veryLightPurpleLine];\n  } else if (\n    domainType === 'Immunoglobulin C1-set' ||\n    domainType.includes('GTPase') ||\n    domainType === 'Major facilitator superfamily' ||\n    domainType === 'Fibronectin type II domain' ||\n    domainType.includes('ectodomain') ||\n    domainType.endsWith('receptor domain') ||\n    domainType.endsWith('receptor domain 4')\n  ) {\n    return [lightPurple, lightPurpleLine];\n  } else if (\n    domainType === 'Immunoglobulin C2-set' ||\n    domainType.includes('immunoglobulin C2-set') ||\n    domainType.includes('protein interaction')\n  ) {\n    return [purple, purpleLine];\n  } else if (domainType === 'Immunoglobulin V-set domain') {\n    return [darkPurple, darkPurpleLine];\n  } else if (domainType === 'Immunoglobulin I-set') {\n    return [purple2, purple2Line];\n  }\n\n  else if (\n    // Repeats\n    domainType === 'Armadillo' ||\n    domainType.includes('Apple domain') ||\n    domainType === 'Protocadherin' || // Cytoplasmic\n    domainType.endsWith('merisation domain') // e.g. di- / tetramerisation\n  ) {\n    return [orange, orangeLines];\n  } else if (\n    domainType.includes('Kringle') ||\n    domainType.includes('Peptidase M12A') ||\n    domainType === 'TGF-beta, propeptide' ||\n    domainType === 'PIK-related kinase' ||\n    domainType.includes('(PIK) domain') ||\n    domainType === 'LDLR class B repeat' ||\n    domainType === 'Cadherin-like' ||\n    domainType === 'Actin family'\n  ) {\n    return [lightBrown, lightBrownLine];\n  } else if (\n    // Transmembrane\n    domainType.includes('transmembrane domain') ||\n    domainType.includes('Transmembrane protein') ||\n    domainType.includes('Collectrin') ||\n    domainType.includes('cytoplasmic domain')\n  ) {\n    return [brown, brownLine];\n  }\n\n  else if (\n    // Death, ubiquitination\n    domainType === 'CARD domain' ||\n    domainType === 'Death effector domain' ||\n    domainType === 'Death domain' ||\n    domainType === 'Ubiquitin-associated domain' ||\n    domainType.includes('UBA domain')\n  ) {\n    return [darkGrey, darkGreyLine];\n  } else if (\n    domainType.includes('repeat') ||\n    domainType === 'Vitellinogen, open beta-sheet'\n  ) {\n    return [orange, orangeLines];\n  } else if (\n    domainType.includes('inhibit')\n  ) {\n    return [seafoam, seafoamLines];\n  } else if (\n    domainType.includes('Peptidase')\n  ) {\n    return [blue, blueLines];\n  } else if (\n    // C-terminal regions are typically colored red in e.g. PyMol rainbow\n    domainType.includes('C-termin') ||\n    domainType.includes('C termin')\n  ) {\n    return [faintRed, faintRedLines];\n  } else if (\n    // N-terminal regions are typically colored blue in e.g. PyMol rainbow\n    domainType.includes('N-termin') ||\n    domainType.includes('N termin')\n  ) {\n    return [lightBlue, lightBlueLine];\n  }\n\n  return [grey, greyLines];\n}\n","/**\n * @fileoverview Functions to render 2D protein structure, i.e. linear domains\n *\n * The protein diagrams are shown in the Gene Leads tooltip.\n */\n\nimport {addPositions, getGeneFromStructureName, pipe} from './gene-structure';\nimport {getColors} from './protein-color';\n\n/** Get subtle line to visually demarcate domain boundary */\nfunction getDomainBorderLines(x, y, width, lineColor) {\n  const height = 10;\n  const lineHeight = y + height;\n  const lineStroke = `stroke=\"${lineColor}\"`;\n  const leftLineAttrs =\n    `x1=\"${x}\" x2=\"${x}\" y1=\"${y}\" y2=\"${lineHeight}\" ${lineStroke}`;\n\n  const x2 = x + width;\n  const rightLineAttrs =\n    `x1=\"${x2}\" x2=\"${x2}\" y1=\"${y}\" y2=\"${lineHeight}\" ${lineStroke}`;\n\n  const startBorder = `<line class=\"subpart-line\" ${leftLineAttrs} />`;\n  const endBorder = `<line class=\"subpart-line\" ${rightLineAttrs} />`;\n\n  return startBorder + endBorder;\n}\n\n/** Get start and length for coding sequence (CDS), in pixels and base pairs */\nfunction getCdsCoordinates(subparts, isPositiveStrand) {\n  // Test case: XRCC3 (-, multiple 5'-UTRs), RAD51D (big 3'-UTR)\n  if (!isPositiveStrand) subparts = subparts.slice().reverse();\n\n  // Start of CDS is end of last 5'-UTR, for default case (positive strand)\n  const startUtr = isPositiveStrand ? \"5'-UTR\" : \"3'-UTR\";\n  const lastStartUtr = subparts.filter(s => s[0] === startUtr).slice(-1)[0];\n  let startPx, startBp;\n  if (lastStartUtr) {\n    startPx = lastStartUtr[3].x + lastStartUtr[3].width;\n    startBp = lastStartUtr[1] + lastStartUtr[2];\n  } else {\n    // For transcipts without an annotated start UTR, e.g. EGFR-205\n    startPx = 0;\n    startBp = 0;\n  }\n\n  // End of CDS is start of first 3'-UTR, for default case\n  const endUtr = isPositiveStrand ? \"3'-UTR\" : \"5'-UTR\";\n  const firstEndUtr = subparts.filter(s => s[0] === endUtr).slice(-1)[0];\n  let stopPx, stopBp;\n  if (firstEndUtr) {\n    stopPx = firstEndUtr[3].x;\n    stopBp = firstEndUtr[1];\n  } else {\n    // For transcipts without an annotated last UTR, e.g. EGFR-205\n    const lastSubpart = subparts.slice(-1)[0];\n    stopPx = lastSubpart[3].x + lastSubpart[3].width;\n    stopBp = lastSubpart[1] + lastSubpart[2];\n  }\n\n  const lengthBp = stopBp - startBp;\n  const lengthPx = stopPx - startPx;\n\n  const cdsCoordinates = {\n    px: {start: startPx, length: lengthPx},\n    bp: {start: startBp, length: lengthBp}\n  };\n  return cdsCoordinates;\n}\n\n/** Get SVG for an inidividual protein domain */\nfunction getDomainSvg(domain, cds, isPositiveStrand) {\n  const domainType = domain[0];\n  const domainPx = domain[3];\n\n  let x = cds.px.start + domainPx.x;\n  const width = domainPx.width;\n  if (!isPositiveStrand) {\n    x = cds.px.length + cds.px.start - (domainPx.x + domainPx.width);\n  };\n\n  // Perhaps make these configurable, later\n  const y = 40;\n  const height = 10;\n\n  const lengthAa = `${domain[2]}&nbsp;aa`;\n  const title = `data-subpart=\"${domainType} ${pipe} ${lengthAa}\"`;\n  const data = title;\n\n  const pos = `x=\"${x}\" width=\"${width}\" y=\"${y}\" height=\"${height}\"`;\n  const cls = `class=\"subpart domain\" `;\n\n  const [color, lineColor] = getColors(domainType);\n\n  const line = getDomainBorderLines(x, y, width, lineColor);\n  const domainSvg =\n    `<rect ${cls} rx=\"1.5\" fill=\"${color}\" ${pos} ${data}/>` +\n    line;\n\n  return domainSvg;\n}\n\n/** Return whether protein SVG should be shown */\nfunction isEligibleforProteinSvg(gene, ideo) {\n  return (\n    ideo.config.showProteinInTooltip &&\n    !(\n      'proteinCache' in ideo === false ||\n      gene in ideo.proteinCache === false ||\n      ('spliceExons' in ideo === false || ideo.spliceExons === false)\n    )\n  );\n}\n\n/** Get SVG showing 2D protein features, e.g. domains from InterPro */\nexport function getProteinSvg(structureName, subparts, isPositiveStrand, ideo) {\n  const features = [];\n  const gene = getGeneFromStructureName(structureName, ideo);\n\n  const isEligible = isEligibleforProteinSvg(gene, ideo);\n  if (!isEligible) return '';\n\n\n  const entry = ideo.proteinCache[gene].find(d => {\n    return d.transcriptName === structureName;\n  });\n  if (!entry) return '<br/>';\n  const protein = entry.protein;\n  const cds = getCdsCoordinates(subparts, isPositiveStrand);\n\n  const domains = addPositions(subparts, protein);\n\n  for (let i = 0; i < domains.length; i++) {\n    const domain = domains[i];\n    const domainSvg = getDomainSvg(domain, cds, isPositiveStrand);\n    features.push(domainSvg);\n  }\n\n  const proteinSvg =\n    `<g id=\"_ideoProtein\">${features.join('')}</g>`;\n\n  return proteinSvg;\n}\n","import {d3} from '../lib';\nimport {getIcon} from '../annotations/legend';\nimport {getProteinSvg} from './protein';\n\nconst y = 15;\n\n// Subtle visual delimiter; separates horizontally adjacent fields in UI\nexport const pipe = `<span style='color: #CCC'>|</span>`;\n\nconst utr5 = \"5'-UTR\";\nconst utr3 = \"3'-UTR\";\n\nconst heights = {\n  \"5'-UTR\": 20,\n  'exon': 20,\n  'intron': 20,\n  \"3'-UTR\": 20\n};\n\nconst colors = {\n  \"5'-UTR\": '#155069',\n  'exon': '#DAA521',\n  \"intron\": '#FFFFFF00',\n  \"3'-UTR\": '#357089'\n};\n\nconst lineColors = {\n  \"5'-UTR\": '#70A099',\n  'exon': '#BA8501',\n  \"3'-UTR\": '#90C0B9'\n};\n\nconst subpartClasses = {\n  \"5'-UTR\": 'five-prime-utr',\n  'exon': 'exon',\n  \"3'-UTR\": 'three-prime-utr',\n  'intron': 'intron'\n};\n\nconst css =\n  `<style>\n  ._ideoGeneStructureContainerName {\n    margin-left: 81px;\n  }\n  ._ideoGeneStructureContainerName.pre-mRNA {\n    margin-left: 69px;\n  }\n  ._ideoGeneStructureContainer rect:hover + line {\n    visibility: hidden;\n  }\n  ._ideoGeneStructureContainer {\n    display: flex;\n    justify-content: center;\n    align-items: center;\n    flex-direction: column;\n  }\n  ._ideoGeneStructureContainer:hover ._ideoSpliceToggle {\n    visibility: visible;\n  }\n  ._ideoGeneStructureContainer ._ideoSpliceToggle {\n    visibility: hidden;\n  }\n  ._ideoSpliceToggle {\n    margin-left: 53px; background-color: #EEE;\n  }\n  ._ideoSpliceToggle.pre-mRNA {\n    margin-left: 43px; background-color: #F8F8F8;\n  }\n  ._ideoHoveredSubpart {\n    stroke: #D0D0DD !important; stroke-width: 3px;\n  }\n  </style>`;\n\n/** Get DOM element for gene structure footer */\nfunction getFooter() {\n  return document.querySelector('._ideoGeneStructureFooter');\n}\n\n/** Write transcript details below the diagram */\nfunction writeFooter(container) {\n  const footer = getFooter();\n  const svgDOM = container.querySelector('svg');\n  const transcriptSummary = svgDOM.getAttribute('data-ideo-footer');\n  footer.innerHTML = `&nbsp;<br/>${transcriptSummary}`;\n}\n\n/** Write newly-selected gene structure diagram, header, and footer */\nfunction updateGeneStructure(ideo, offset=0) {\n  const [structure, selectedIndex] = getSelectedStructure(ideo, offset);\n  const isCanonical = (selectedIndex === 0);\n  const menu = document.querySelector('#_ideoGeneStructureMenu');\n  menu.options[selectedIndex].selected = true;\n  const svg = getSvg(structure, ideo, ideo.spliceExons)[0];\n  const container = document.querySelector('._ideoGeneStructureSvgContainer');\n  container.innerHTML = svg;\n  updateHeader(ideo.spliceExons, isCanonical);\n  writeFooter(container);\n  ideo.addedSubpartListeners = false;\n  addHoverListeners(ideo);\n}\n\n/** Get gene symbol from transcript / gene structure name */\nexport function getGeneFromStructureName(structureName) {\n  const gene = structureName.split('-').slice(0, -1).join('-');\n  return gene;\n}\n\n/** Get name of transcript currently selected in menu */\nfunction getSelectedStructure(ideo, offset=0) {\n  let selectedIndex, structureName;\n\n  const menu = document.querySelector('#_ideoGeneStructureMenu');\n  if (!menu) {\n    const svg = document.querySelector('._ideoGeneStructure');\n    if (!svg) return null; // No gene structure is available, e.g. for miRNA\n    structureName = svg.getAttribute('data-ideo-gene-structure-name');\n    selectedIndex = 0;\n  } else {\n    const numOptions = menu.options.length;\n    const baseIndex = menu.selectedIndex;\n    selectedIndex = baseIndex + offset;\n    if (selectedIndex >= numOptions) {\n      selectedIndex = 0;\n    } else if (selectedIndex < 0) {\n      selectedIndex = numOptions - 1;\n    }\n    structureName = menu.options[selectedIndex].value;\n  }\n  const gene = getGeneFromStructureName(structureName);\n  const geneStructure =\n    ideo.geneStructureCache[gene].find(gs => gs.name === structureName);\n\n\n  return [geneStructure, selectedIndex];\n}\n\n/**\n * Add event listeners to the transcript menu:\n * - On click, block upstream listeners from closing tooltip\n * - On change, write newly selected gene structure\n */\nfunction addMenuListeners(ideo) {\n  const menuId = '_ideoGeneStructureMenu';\n  const container = document.querySelector('._ideoGeneStructureContainer');\n\n  // Don't search this gene if clicking to expand the menu\n  container.addEventListener('click', (event) => {\n    if (event.target.id === menuId) {\n      event.stopPropagation();\n    }\n\n    let svgMaybe = event.target;\n    if (svgMaybe.parentElement.tagName === 'svg') {\n      svgMaybe = svgMaybe.parentElement;\n    };\n\n    // Go to next transcript on clicking down arrow icon, previous on up\n    if (Array.from(svgMaybe.classList).includes('_ideoMenuArrow')) {\n      const menuArrow = event.target;\n      const direction = menuArrow.getAttribute('data-dir');\n      const offset = direction === 'down' ? 1 : -1;\n      updateGeneStructure(ideo, offset);\n      event.stopPropagation();\n    }\n  });\n\n  // Go to next transcript on pressing down arrow key, previous on up\n  document.addEventListener('keydown', (event) => {\n    const key = event.key;\n    if (['ArrowDown', 'ArrowUp'].includes(key)) {\n      const offset = key === 'ArrowDown' ? 1 : -1;\n      updateGeneStructure(ideo, offset);\n    }\n  });\n}\n\nfunction toggleSpliceByKeyboard(event) {\n  if (event.key === 's') {\n    const spliceToggle = document.querySelector('._ideoSpliceToggle input');\n    if (!spliceToggle) return;\n\n    const subpartText = document.querySelector('#_ideoSubpartText');\n    if (subpartText) subpartText.innerHTML = '&nbsp;';\n    spliceToggle.dispatchEvent(new MouseEvent('click'));\n  }\n}\n\n/** Listen for keydown and click on / change to splice toggle input */\nfunction addSpliceToggleListeners(ideo) {\n  document.addEventListener('keydown', toggleSpliceByKeyboard);\n\n  const container = document.querySelector('._ideoGeneStructureContainer');\n  const toggler = document.querySelector('._ideoSpliceToggle');\n\n  if (!container) return;\n\n  toggler.addEventListener('change', (event) => {\n    toggleSplice(ideo);\n    addHoverListeners(ideo);\n    event.stopPropagation();\n  });\n}\n\n/** Helper for keyboard navigation */\nfunction nextIsOutOfSubpartBounds(i, subparts, key) {\n  const isLeft = key === 'left';\n  return (\n    i === 0 && isLeft ||\n    i === subparts.length - 1 && !isLeft\n  );\n}\n\n/**\n * Swap genome-ordered subparts so they render with expected visual layering\n *\n * SVG elements render last-on-top, which often hides subparts UTRs at the\n * ends of transcripts when they're genomically ordered, as they are in e.g.\n * Ensembl.\n *\n * See also: swapUTRsBack\n */\nfunction swapUTRsForward(subparts, isPositiveStrand) {\n  const swappedSubparts = subparts.slice();\n\n  // Account for edge case in certain nonsense-mediated-decay transcripts\n  const utr = isPositiveStrand ? utr3 : utr5;\n  const hasUtr = subparts.some(subpart => subpart[0] === utr);\n\n  subparts.forEach((subpart, i) => {\n    if (i === 0) return;\n    const prevSubpart = subparts[i - 1];\n\n    const prevIsUtr3 = prevSubpart[0] === utr3;\n    const prevIsUtr5 = prevSubpart[0] === utr5;\n    const isExon = subpart[0] === 'exon';\n\n    if (\n      isExon && hasUtr && (\n        !isPositiveStrand && prevIsUtr3 ||\n        isPositiveStrand && prevIsUtr5\n      )\n    ) {\n      swappedSubparts[i] = prevSubpart;\n      swappedSubparts[i - 1] = subpart;\n    }\n  });\n\n  return swappedSubparts;\n}\n\nwindow.swapUTRsForward = swapUTRsForward;\n\nfunction is(element, cls) {\n  return element.classList.contains(cls);\n}\n\n// isExon && (\n//   !isPositiveStrand && prevIsUtr3 ||\n//   isPositiveStrand && prevIsUtr5\n// )\n\nfunction shouldSwapBackDOM(subpart, nextSubpart, isPositiveStrand, hasUtr) {\n  const utr5 = 'five-prime-utr';\n  const utr3 = 'three-prime-utr';\n  const nextIsUtr5 = is(nextSubpart, utr5);\n  const nextIsUtr3 = is(nextSubpart, utr3);\n  const isNotUtr3 = !is(subpart, utr3);\n  const isNotUtr5 = !is(subpart, utr5);\n  return (\n    hasUtr && (\n      !isPositiveStrand && nextIsUtr3 && isNotUtr3 ||\n      isPositiveStrand && nextIsUtr5 && isNotUtr5\n    )\n  );\n}\n\nfunction shouldSwapBackData(subpart, nextSubpart, isPositiveStrand, hasUtr) {\n  const nextIsUtr5 = nextSubpart[0] === utr5;\n  const nextIsUtr3 = nextSubpart[0] === utr3;\n  const isNotUtr3 = subpart[0] !== utr3;\n  const isNotUtr5 = subpart[0] !== utr5;\n  return (\n    hasUtr && (\n      !isPositiveStrand && nextIsUtr3 && isNotUtr3 ||\n      isPositiveStrand && nextIsUtr5 && isNotUtr5\n    )\n  );\n}\n\n/**\n * Restore SVG subparts to genome order, for proper keyboard navigation\n *\n * See also: swapUTRsForward\n */\nfunction swapUTRsBack(subparts, isPositiveStrand) {\n  const swappedSubparts = subparts.slice();\n  const isRaw = Array.isArray(subparts[0]);\n\n  // Account for edge case in animating exon splice for\n  // nonsense-mediated-decay transcripts that lack an annotated UTR,\n  // e.g. SREBF-204\n  let hasUtr;\n  if (isRaw) {\n    const utr = isPositiveStrand ? utr3 : utr5;\n    hasUtr = subparts.some(subpart => subpart[0] === utr);\n  } else {\n    const utr5 = 'five-prime-utr';\n    const utr3 = 'three-prime-utr';\n    const utr = isPositiveStrand ? utr3 : utr5;\n    hasUtr = subparts.some(subpart => is(subpart, utr));\n  }\n\n  subparts.forEach((subpart, i) => {\n    if (i === swappedSubparts.length - 1) return;\n    const nextSubpart = subparts[i + 1];\n    const shouldSwapBackFn = isRaw ? shouldSwapBackData : shouldSwapBackDOM;\n    const shouldSwapBack =\n      shouldSwapBackFn(subpart, nextSubpart, isPositiveStrand, hasUtr);\n    if (shouldSwapBack) {\n      swappedSubparts.splice(i, 1, nextSubpart);\n      swappedSubparts.splice(i + 1, 1, subpart);\n    }\n  });\n  return swappedSubparts;\n}\n\n/**\n * Remove any hover stroke outlines, for subpart highlight edge cases like\n * mouseenter in subpart A while distant subpart B is navigated\n */\nfunction removeHighlights() {\n  const cls = '_ideoHoveredSubpart';\n  const hovereds = document.querySelectorAll(`.${cls}`);\n  hovereds.forEach(el => el.classList.remove(cls));\n}\n\n\n/** Go to previous subpart on left arrow; next on right */\nfunction navigateSubparts(event) {\n  const domSubparts = Array.from(document.querySelectorAll('rect.subpart'));\n\n  const structure = document.querySelector('._ideoGeneStructure');\n  const strand = structure.getAttribute('data-ideo-strand');\n  const isPositiveStrand = strand === '+';\n\n  const subparts = swapUTRsBack(domSubparts, isPositiveStrand);\n\n  if (subparts.length === 0) return; // E.g. paralog neighborhoods, lncRNA\n  const cls = '_ideoHoveredSubpart';\n  const subpart = document.querySelector(`.${cls}`);\n  if (!subpart) {\n    // Accounts for edge case when changing transcripts via menu\n    event.stopPropagation();\n    event.preventDefault();\n    return;\n  }\n  let i;\n  subparts.forEach((el, index) => {\n    if (el.classList.contains(cls)) {\n      i = index;\n    }\n  });\n\n  const options = {view: window, bubbles: false, cancelable: true};\n  const mouseEnter = new MouseEvent('mouseenter', options);\n  const mouseLeave = new MouseEvent('mouseleave', options);\n\n  // Account for strand, so left key always goes left; right always right\n  const left = isPositiveStrand ? 'ArrowLeft' : 'ArrowRight';\n  const right = isPositiveStrand ? 'ArrowRight' : 'ArrowLeft';\n  let key;\n  if (event.key === left) {\n    key = 'left';\n  } else if (event.key === right) {\n    key = 'right';\n  }\n\n  // Don't fall off the end\n  if (\n    typeof key === 'undefined' ||\n    nextIsOutOfSubpartBounds(i, subparts, key)\n  ) {\n    event.stopPropagation();\n    event.preventDefault();\n    return;\n  }\n\n  removeHighlights();\n  const alt = event.altKey;\n  const meta = event.metaKey;\n\n  // Jump forward or back by 1, 10, or all subparts\n  if (event.key === left) { // Jump back\n    subpart.dispatchEvent(mouseLeave);\n    let index = i - 1;\n    if (alt) index = i - 10 < 0 ? 0 : i - 10;\n    if (meta) index = 0;\n    const prevSubpart = subparts[index];\n    prevSubpart.dispatchEvent(mouseEnter);\n  } else if (event.key === right) { // Jump forward\n    subpart.dispatchEvent(mouseLeave);\n    const last = subparts.length - 1;\n    let index = i + 1;\n    if (alt) index = i + 10 > last ? last : i + 10;\n    if (meta) index = last;\n    const nextSubpart = subparts[index];\n    nextSubpart.dispatchEvent(mouseEnter);\n  }\n  event.stopPropagation();\n  event.preventDefault();\n}\n\nfunction getMenuContainer() {\n  return document.querySelector('#_ideoGeneStructureMenuContainer');\n}\n\nfunction addSubpartHoverListener(subpartDOM, ideo) {\n  const subpart = subpartDOM;\n\n  // On hovering over subpart, highlight it and show details\n  subpart.addEventListener('mouseenter', event => {\n    removeHighlights();\n    // Highlight hovered subpart, adding an aura around it\n    event.target.classList.add('_ideoHoveredSubpart');\n    // Show details\n    const footer = getFooter();\n    ideo.originalTooltipFooter = footer.innerHTML;\n    const subpartText = subpart.getAttribute('data-subpart');\n    const trimmedFoot = footer.innerHTML.replace('&nbsp;', '');\n    const style = 'style=\"margin-bottom: -10px; max-width: 260px;\"';\n    const id = 'id=\"_ideoSubpartText\"';\n    footer.innerHTML =\n      `<div ${id} ${style}\">${subpartText}</div>${trimmedFoot}`;\n    const menuContainer = getMenuContainer();\n    if (menuContainer) menuContainer.style.marginTop = '';\n  });\n\n  // On hovering out, de-highlight and hide details\n  subpart.addEventListener('mouseleave', event => {\n    event.target.classList.remove('_ideoHoveredSubpart');\n    const footer = getFooter();\n    footer.innerHTML = ideo.originalTooltipFooter;\n    const menuContainer = getMenuContainer();\n    if (menuContainer) menuContainer.style.marginTop = '4px';\n  });\n}\n\n/** Did the mouse event occur inside the tooltip area? */\nfunction isMouseEventInTooltip(event) {\n  const tooltip = document.querySelector('._ideogramTooltip');\n  const box = tooltip.getBoundingClientRect();\n  const x = event.screenX;\n  const y = event.screenY;\n  const inTooltip =\n    (x > box.left && x < box.right && y > box.top && y < box.bottom);\n  return inTooltip;\n}\n\n/**\n * Add handlers for hover events in transcript container and beneath, e.g.:\n *\n * - Show transcript details on hovering near transcript\n * - Show subpart (i.e. exon, 3'-UTR, 5'-UTR) details on hovering over subpart\n * - Highlight subpart on hovering over subpart\n * - Navigate to previous or next subpart on pressing left or right arrow keys\n */\nfunction addHoverListeners(ideo) {\n\n  const subparts = document.querySelectorAll('rect.subpart');\n  if (subparts.length === 0) return; // E.g. paralog neighborhoods, lncRNA\n\n  ideo.subparts = subparts;\n\n  const container = document.querySelector('._ideoGeneStructureContainer');\n\n  container.addEventListener('mouseenter', () => {\n    document.addEventListener('keydown', navigateSubparts);\n    if (ideo.addedMenuListeners) return;\n    ideo.addedMenuListeners = true;\n    writeFooter(container);\n\n    // Listen for change of selected option in transcript menu\n    const tooltip = document.querySelector('._ideogramTooltip');\n    tooltip.addEventListener('change', () => {\n      updateGeneStructure(ideo);\n\n      // Without this, selecting a new transcript will close the tooltip if\n      // the selected <option> screen position is outside the tooltip (as\n      // is often the case in genes with many transcripts, like TP53).\n      ideo.oneTimeDelayTooltipHideMs = 2000; // wait 2.0 s instead of 0.25 s\n    });\n\n  });\n  container.addEventListener('mouseleave', (event) => {\n    ideo.oneTimeDelayTooltipHideMs = 2000; // See \"Without this...\" note above\n    const inTooltip = isMouseEventInTooltip(event);\n    if (inTooltip === true) {\n      // Only remove transcript footer if `mouseleave` event is from footer to\n      // another part of the tooltip.  If `mouseleave`-ing from footer to\n      // *outside* the tooltip -- e.g. when selecting a new transcript as in\n      // the \"Without this...\" scenario noted above -- then do not remove the\n      // footer.  This lets users always see the details in the footer for the\n      // transcript they just selected, rather than having the details\n      // frustratingly disappear immediately upon transcript selection.\n      const footer = getFooter();\n      footer.innerHTML = '';\n    }\n    ideo.addedMenuListeners = false;\n    document.removeEventListener('keydown', navigateSubparts);\n  });\n\n  if (ideo.addedSubpartListeners) return;\n  ideo.addedSubpartListeners = true;\n\n  subparts.forEach(subpart => {\n    addSubpartHoverListener(subpart, ideo);\n  });\n}\n\nfunction writeStrandInFooter(ideo) {\n  const strand = getSelectedStructure(ideo)[0].strand;\n  if (strand === '+') return; // Don't remark if strand is the default\n  const tooltipFooter = document.querySelector('._ideoTooltipFooter');\n  tooltipFooter.innerText =\n    tooltipFooter.innerText.replace(')', `, ${strand})`);\n}\n\nexport function addGeneStructureListeners(ideo) {\n  const structure = getSelectedStructure(ideo);\n  if (structure === null) return; // Bail for e.g. miRNA\n  addSpliceToggleListeners(ideo);\n  addHoverListeners(ideo);\n  addMenuListeners(ideo);\n  writeStrandInFooter(ideo);\n}\n\nfunction getSpliceToggleHoverTitle(spliceExons) {\n  return spliceExons ? 'Unsplice exons (s)' : 'Splice exons (s)';\n}\n\nfunction getSpliceToggle(ideo) {\n  const spliceExons = ideo.spliceExons;\n  const modifier = spliceExons ? '' : 'pre-';\n  const cls = `class=\"_ideoSpliceToggle ${modifier}mRNA\"`;\n  const checked = spliceExons ? 'checked' : '';\n  const text = getSpliceToggleHoverTitle(spliceExons);\n  const title = `title=\"${text}\"`;\n  const inputAttrs =\n    `type=\"checkbox\" ${checked} ` +\n    `style=\"display: none;\"`;\n  const style =\n    'style=\"position: relative; top: -5px; ' +\n    'user-select: none; ' + // Prevent distracting highlight on quick toggle\n    'float: right; cursor: pointer; font-size: 16px; ' +\n    'padding: 2px 4px; border: 1px solid #CCC; border-radius: 3px;\"';\n  const attrs = `${cls} ${style} ${title}`;\n\n  // Scissors icon\n  const label = `<label ${attrs}><input ${inputAttrs} />&#x2702;</label>`;\n  return label;\n}\n\n/** Splice exons in transcript, removing introns; add positions */\nfunction spliceOut(subparts) {\n  const splicedSubparts = [];\n  let prevEnd = 0;\n  let prevStart = 0;\n  for (let i = 0; i < subparts.length; i++) {\n    const subpart = subparts[i];\n    const [subpartType, start, length] = subpart;\n    const isSpliceOverlap = start === prevStart;\n    let prevRawStart, prevRawLength;\n    if (i > 0) {\n      [, prevRawStart, prevRawLength] = subparts[i - 1];\n    }\n\n    // e.g. 5'-UTRs of OXTR\n    const isOtherOverlap = i > 0 && start === prevRawStart;\n\n    // e.g. 3'-UTR of LDLR, or 3'-UTR of CD44\n    const isOther3UTROverlap = i > 0 && start <= prevRawStart + prevRawLength;\n\n    let splicedStart;\n    if (isSpliceOverlap) {\n      splicedStart = start;\n    } else if (isOtherOverlap) {\n      // e.g. 5'-UTRs of OXTR\n      splicedStart = prevStart;\n    } else if (isOther3UTROverlap) {\n      splicedStart = prevStart + prevRawLength - length;\n    } else {\n      splicedStart = prevEnd;\n    }\n    const splicedEnd = splicedStart + length;\n    const splicedSubpart = [subpartType, splicedStart, length + 1];\n    splicedSubparts.push(splicedSubpart);\n    prevEnd = splicedEnd;\n    prevStart = splicedStart;\n  }\n  const splicedPositionedSubparts = addPositions(splicedSubparts);\n  return splicedPositionedSubparts;\n}\n\n/** Insert introns to transcript; add positions */\nfunction spliceIn(subparts) {\n  const splicedSubparts = [];\n  let prevEnd = 0;\n  for (let i = 0; i < subparts.length; i++) {\n    const subpart = subparts[i];\n    const [start, length] = subpart.slice(1);\n    if (start > prevEnd) {\n      const intronStart = prevEnd;\n      const intronLength = start - prevEnd - 1;\n      splicedSubparts.push(['intron', intronStart, intronLength]);\n    }\n    prevEnd = start + length;\n    splicedSubparts.push(subpart);\n  }\n  const splicedPositionedSubparts = addPositions(splicedSubparts);\n  return splicedPositionedSubparts;\n}\n\nfunction getSpliceStateText(spliceExons, isCanonical=true) {\n  let modifier = '';\n  let titleMod = 'without';\n  if (!spliceExons) {\n    modifier = 'pre-';\n    titleMod = 'with';\n  }\n  const canonOrAlt = isCanonical ? 'Canonical' : 'Alternative';\n  const title = `${canonOrAlt} transcript per Ensembl, ${titleMod} introns`;\n  const name = `${canonOrAlt} ${modifier}mRNA`;\n  return {title, name};\n}\n\n\n/** Draw introns in initial splice toggle from mRNA to pre-mRNA */\nfunction drawIntrons(prelimSubparts, matureSubparts, ideo) {\n  // Hypothetical example data, in shorthand\n  // pres = [u5_1, e1, i1, e2, i2, e3, i3, e4, i4, e5, i5, e6, u3_1]\n  // mats = [u5_1, e1, e2, e3, e4, e5, e6, u3_1]\n\n  let numInserted = 0;\n  const subpartEls = document.querySelectorAll('.subpart');\n  prelimSubparts.forEach((prelimSubpart, i) => {\n    const matureIndex = i - numInserted;\n    const matureSubpart = matureSubparts[matureIndex];\n    if (matureSubpart[0] !== prelimSubpart[0]) {\n      const summary = prelimSubpart[3].summary;\n      const otherAttrs = `y=\"15\" height=\"20\" fill=\"#FFFFFF00\" ${summary}`;\n      const intronRect =\n        `<rect class=\"subpart intron\" ${otherAttrs} />`;\n      subpartEls[matureIndex].insertAdjacentHTML('beforebegin', intronRect);\n      numInserted += 1;\n    }\n  });\n\n  document.querySelectorAll('.intron').forEach(subpartDOM => {\n\n    addSubpartHoverListener(subpartDOM, ideo);\n  });\n}\n\nfunction updateHeader(spliceExons, isCanonical) {\n  // Update title for gene structure diagram\n  const nameDOM =\n  document.querySelector('._ideoGeneStructureContainerName');\n  const toggleDOM = document.querySelector('._ideoSpliceToggle');\n\n  if (nameDOM && toggleDOM) {\n    [nameDOM, toggleDOM].forEach(el => el.classList.remove('pre-mRNA'));\n    if (!spliceExons) {\n      [nameDOM, toggleDOM].forEach(el => el.classList.add('pre-mRNA'));\n    }\n    const {title, name} = getSpliceStateText(spliceExons, isCanonical);\n    nameDOM.textContent = name;\n    nameDOM.title = title;\n  }\n}\n\nfunction toggleSplice(ideo) {\n  ideo.spliceExons = !ideo.spliceExons;\n  const spliceExons = ideo.spliceExons;\n  const [structure, selectedIndex] = getSelectedStructure(ideo);\n  const isCanonical = (selectedIndex === 0);\n  const [, prelimSubparts, matureSubparts] =\n    getSvg(structure, ideo, spliceExons);\n  const proteinSvg = document.querySelector('#_ideoProtein');\n\n  if (proteinSvg && !spliceExons) proteinSvg.style.display = 'none';\n\n  const addedIntrons = document.querySelectorAll('.intron').length > 0;\n  if (!spliceExons && !addedIntrons) {\n    drawIntrons(prelimSubparts, matureSubparts, ideo);\n  } else {\n    document.querySelectorAll('.intron').forEach(el => el.remove());\n  }\n  document.querySelectorAll('.subpart-line.rna').forEach(el => el.remove());\n\n  const subparts = spliceExons ? matureSubparts : prelimSubparts;\n\n  d3.select('._ideoGeneStructure').selectAll('.subpart')\n    .data(subparts)\n    .transition()\n    .duration(750)\n    .attr('x', (d, i) => subparts[i][3].x)\n    .attr('width', (d, i) => subparts[i][3].width)\n    .on('end', (d, i) => {\n      if (i !== subparts.length - 1) return;\n      if (proteinSvg && spliceExons) proteinSvg.style.display = '';\n\n      // Restore subpart boundary lines\n      const subpartDOMs = document.querySelectorAll('.subpart:not(.domain)');\n      subpartDOMs.forEach((subpartDOM, i) => {\n        const subpart = subparts[i];\n        const line = getSubpartBorderLine(subpart);\n        subpartDOM.insertAdjacentHTML('afterend', line);\n      });\n\n      updateHeader(spliceExons, isCanonical);\n\n      const tlbpDOM = document.querySelector('#_ideoTranscriptLengthBp');\n      if (!tlbpDOM) return;\n      const transcriptLengthBp = getTranscriptLengthBp(subparts, spliceExons);\n      const prettyLength = transcriptLengthBp.toLocaleString();\n      tlbpDOM.innerText = `${prettyLength} bp`;\n    });\n}\n\nfunction getTranscriptLengthBp(subparts, spliceExons=false) {\n  const exons = subparts.filter(sp => sp[0] === 'exon');\n  if (spliceExons) subparts = exons;\n\n  const lastSubpart = subparts.slice(-1)[0];\n  const lastStart = lastSubpart[1];\n  const lastLength = lastSubpart[2];\n  const exonFill = spliceExons ? exons.length - 1 : 0;\n\n  const transcriptLengthBp = lastStart + lastLength + exonFill;\n  return transcriptLengthBp;\n}\n\n/** Merge feature type, pixel-x position, and pixel width to each feature */\nexport function addPositions(subparts, domains=null) {\n  const transcriptLengthPx = 250;\n\n  const totalLengthBp = getTranscriptLengthBp(subparts);\n\n  const factor = domains ? 3 : 1; // 3 nt per aa\n  const bpPerPx = (totalLengthBp / transcriptLengthPx) / factor;\n\n  const features = domains ?? subparts;\n\n  for (let i = 0; i < features.length; i++) {\n    const feature = features[i];\n    if (feature.length !== 3) continue;\n    // Define subpart position, tooltip footer\n    const lengthBp = feature[2];\n    const x = feature[1] / bpPerPx;\n    const width = lengthBp / bpPerPx;\n    const type = feature[0];\n\n    features[i].push({type, x, width});\n  }\n\n  return features;\n}\n\n/** Get text shown below diagram upon hovering over an exon, intron, or UTR */\nfunction getSubpartSummary(subpartType, total, index, strand, lengthBp) {\n  if (strand === '-') index = total - index + 1;\n  const numOfTotal = total > 1 ? `${index} of ${total} ` : '';\n  const prettyType = subpartType[0].toUpperCase() + subpartType.slice(1);\n  const prettyLength = lengthBp.toLocaleString();\n  const html = `${prettyType} ${numOfTotal}${pipe} ${prettyLength} bp`;\n  const summary = `data-subpart=\"${html}\"`;\n  return summary;\n}\n\n/** Get subtle line to visually demarcate subpart boundary */\nfunction getSubpartBorderLine(subpart) {\n  const subpartType = subpart[0];\n  // Define subpart border\n  const x = subpart[3].x;\n  const height = heights[subpartType];\n  const lineHeight = y + height;\n  const lineStroke = `stroke=\"${lineColors[subpartType]}\"`;\n  const lineAttrs = // \"\";\n    `x1=\"${x}\" x2=\"${x}\" y1=\"${y}\" y2=\"${lineHeight}\" ${lineStroke}`;\n  return `<line class=\"subpart-line rna\" ${lineAttrs} />`;\n}\n\n// function getSvgList(gene, ideo, spliceExons=false) {\n//   if (\n//     'geneStructureCache' in ideo === false ||\n//     gene in ideo.geneStructureCache === false\n//   ) {\n//     return [null];\n//   }\n\n//   const svgList = ideo.geneStructureCache[gene].map(geneStructure => {\n//     return getSvg(geneStructure, ideo, spliceExons);\n//   });\n\n//   return svgList;\n// }\n\n/** Get SVG, and prelimnary and mature subparts for given gene structure */\nfunction getSvg(geneStructure, ideo, spliceExons=false) {\n  const strand = geneStructure.strand;\n\n  const rawSubparts = geneStructure.subparts;\n  let subparts;\n\n  // Add pixel coordinates to subparts, and pre-mRNA and mRNA sets\n  let prelimSubparts = spliceIn(rawSubparts);\n  let matureSubparts = spliceOut(rawSubparts);\n  if (spliceExons) {\n    subparts = matureSubparts;\n  } else {\n    subparts = prelimSubparts;\n  }\n\n  const spliceToggle = document.querySelector('._ideoSpliceToggle');\n  if (spliceToggle) {\n    const title = getSpliceToggleHoverTitle(spliceExons);\n    spliceToggle.title = title;\n  }\n\n  const featureLengthPx = 250 - 2; // Snip to avoid overextending\n\n  const intronHeight = 1;\n  const intronColor = 'black';\n  const geneStructureArray = [];\n\n  const intronPosAttrs =\n    `x=\"0\" width=\"${featureLengthPx}\" y=\"${y + 10}\" height=\"${intronHeight}\"`;\n  const intronRect =\n    `<rect fill=\"black\" ${intronPosAttrs}/>`;\n\n  geneStructureArray.push(intronRect);\n\n  // Set up counters for e.g. \"Exon 2 of 4\" (\"<subpart> <num> of <total>\")\n  const indexBySubpart = {\n    \"5'-UTR\": 0,\n    'exon': 0,\n    'intron': 0,\n    \"3'-UTR\": 0\n  };\n  const totalBySubpart = {\n    \"5'-UTR\": 0,\n    'exon': 0,\n    'intron': 0,\n    \"3'-UTR\": 0\n  };\n\n  const isPositiveStrand = strand === '+';\n  subparts = swapUTRsForward(subparts, isPositiveStrand);\n\n  prelimSubparts = swapUTRsForward(prelimSubparts, isPositiveStrand);\n  matureSubparts = swapUTRsForward(matureSubparts, isPositiveStrand);\n\n  // Container for positional data: x, width\n  // const prelimPositions = getPositions(prelimSubparts);\n  // const maturePositions = getPositions(matureSubparts);\n\n  // matureSubparts = matureSubparts.filter(p => p[0] !== 'intron');\n  // const positions = spliceExons ? trimmedMatures : prelimPositions;\n\n  // Get counts for e.g. \"4\" in \"Exon 2 of 4\"\n  for (let i = 0; i < subparts.length; i++) {\n    const subpart = subparts[i];\n    const subpartType = subpart[0];\n    if (subpartType in totalBySubpart) {\n      totalBySubpart[subpartType] += 1;\n    }\n  }\n\n  for (let i = 0; i < subparts.length; i++) {\n    const subpart = subparts[i];\n    // const position = positions[i];\n    const subpartType = subpart[0];\n    let color = intronColor;\n    if (subpartType in colors) {\n      color = colors[subpartType];\n    }\n\n    const height = heights[subpartType];\n\n    // Define subpart position, tooltip footer\n    const lengthBp = subpart[2];\n    const x = subpart[3].x;\n    const width = subpart[3].width;\n\n    const pos = `x=\"${x}\" width=\"${width}\" y=\"${y}\" height=\"${height}\"`;\n    const cls = `class=\"subpart ${subpartClasses[subpartType]}\" `;\n\n    // TODO: Handle introns better, refine CDS vs. UTR in exons\n    const total = totalBySubpart[subpartType];\n    indexBySubpart[subpartType] += 1;\n    const subpartIndex = indexBySubpart[subpartType];\n    const summary =\n      getSubpartSummary(subpartType, total, subpartIndex, strand, lengthBp);\n    if (!spliceExons) {\n      prelimSubparts[i][3].summary = summary;\n    } else if (subpartType !== 'intron') {\n      matureSubparts[i][3].summary = summary;\n    }\n\n    const subpartSvg = (\n      `<rect ${cls} rx=\"1.5\" fill=\"${color}\" ${pos} ${summary}/>` +\n      getSubpartBorderLine(subpart)\n    );\n    geneStructureArray.push(subpartSvg);\n  }\n\n  const sharedStyle =\n    'position: relative; width: 274px; margin: auto;';\n  let transform = `style=\"${sharedStyle} left: 10px;\"`;\n  if (strand === '-') {\n    transform =\n      'transform=\"scale(-1 1)\" ' +\n      `style=\"${sharedStyle} left: -10px;\"`;\n  }\n\n  const transcriptLengthBp = getTranscriptLengthBp(subparts, spliceExons);\n  const prettyLength = transcriptLengthBp.toLocaleString();\n  const footerDetails = [\n    `${totalBySubpart['exon']} exons`,\n    `<span id='_ideoTranscriptLengthBp'>${prettyLength} bp</span> `\n  ];\n  const biotypeText = geneStructure.biotype.replace(/_/g, ' ');\n  if (biotypeText !== 'protein coding') {\n    footerDetails.push(biotypeText);\n  }\n\n  const structureName = geneStructure.name;\n  const gene = getGeneFromStructureName(structureName);\n  const menu = getMenu(gene, ideo, structureName).replaceAll('\"', '\\'');\n  const footerData = menu + footerDetails.join(` ${pipe} `);\n\n  const proteinSvg = getProteinSvg(\n    structureName, subparts, isPositiveStrand, ideo\n  );\n\n  const svgHeight = proteinSvg === '' ? '40' : '60';\n\n  const geneStructureSvg =\n    `<svg class=\"_ideoGeneStructure\" ` +\n      `data-ideo-gene-structure-name=\"${structureName}\" ` +\n      `data-ideo-strand=\"${strand}\" data-ideo-footer=\"${footerData}\" ` +\n      `width=\"${(featureLengthPx + 20)}\" height=\"${svgHeight}\" ${transform}` +\n    `>` +\n      geneStructureArray.join('') +\n      proteinSvg +\n    '</svg>';\n\n  return [geneStructureSvg, prelimSubparts, matureSubparts];\n}\n\n/** Get down and up arrows for one-click, carousel-like navigation for menu */\nfunction getMenuArrows() {\n\n  // Get attributes\n  const style =\n    'width: 12px; height: 12px; cursor: pointer;' +\n    'user-select: none;'; // Prevent distracting highlight on quick clicks\n  const downStyle = `style=\"${style}; margin-left: 5px;\"`;\n  const upStyle = `style=\"${style}; margin-left: 2px;\"`;\n  const cls = 'class=\"_ideoMenuArrow\"';\n  const downTitle = `<title>Next transcript (down arrow)</title>`;\n  const upTitle = `<title>Previous transcript (up arrow)</title>`;\n  const downAttrs = `${downStyle} ${cls} data-dir=\"down\"`;\n  const upAttrs = `${upStyle} ${cls} data-dir=\"up\"`;\n\n  // Get SVG polygon elements\n  const down = getIcon(\n    {shape: 'triangle', color: '#888'},\n    {config: {orientation: 'down'}}\n  );\n  const up = getIcon({shape: 'triangle', color: '#888'}, {config: ''});\n\n  const downArrow = `<svg ${downAttrs}>${downTitle}${down}</svg>`;\n  const upArrow = `<svg ${upAttrs}>${upTitle}${up}</svg>`;\n  const menuArrows = downArrow + upArrow;\n\n  return menuArrows;\n}\n\n/** Get menu for all transcripts for this gene */\nfunction getMenu(gene, ideo, selectedName) {\n  const containerId = '_ideoGeneStructureMenuContainer';\n  const style = 'margin-bottom: 4px; margin-top: 4px; clear: both;';\n\n  const structures = ideo.geneStructureCache[gene];\n\n  if (structures.length === 1) {\n    const name = structures[0].name;\n    const line =\n      `<div id=\"${containerId}\" style=\"${style}\">Transcript: ${name}</div>`;\n    return line;\n  }\n\n  const options = structures.map(structure => {\n    const name = structure.name;\n    let selected = '';\n    if (selectedName && selectedName === structure.name) {\n      selected = ' selected';\n    }\n    return `<option value=\"${name}\" ${selected}>${name}</option>`;\n  }).join('');\n\n  const id = '_ideoGeneStructureMenu';\n\n  const menuArrows = getMenuArrows();\n\n  const menu =\n    `<div id=\"${containerId}\" style=\"${style}\">` +\n      `<label for=\"${id}\">Transcript:</label> ` +\n      `<select id=\"${id}\" name=\"${id}\">${options}</select>` +\n      menuArrows +\n    `</div>`;\n  return menu;\n}\n\nexport function getGeneStructureHtml(annot, ideo, isParalogNeighborhood) {\n  let geneStructureHtml = '';\n  const gene = annot.name;\n  if (\n    ideo.config.showGeneStructureInTooltip && !isParalogNeighborhood &&\n    !(\n      'geneStructureCache' in ideo === false ||\n      gene in ideo.geneStructureCache === false\n    )\n  ) {\n    ideo.addedSubpartListeners = false;\n    if ('spliceExons' in ideo === false) ideo.spliceExons = true;\n    const spliceExons = ideo.spliceExons;\n    const structure = ideo.geneStructureCache[gene][0];\n    const geneStructureSvg = getSvg(structure, ideo, spliceExons)[0];\n    const cls = 'class=\"_ideoGeneStructureContainer\"';\n    const toggle = getSpliceToggle(ideo);\n    const rnaClass = spliceExons ? '' : ' pre-mRNA';\n    const spanClass = `class=\"_ideoGeneStructureContainerName${rnaClass}\"`;\n    const {name, title} = getSpliceStateText(spliceExons);\n    const spanAttrs = `${spanClass} title=\"${title}\"`;\n    geneStructureHtml =\n      '<br/><br/>' +\n      css +\n      `<div ${cls}>` +\n      `<div><span ${spanAttrs}>${name}</span>${toggle}</div>` +\n      `<span class=\"_ideoGeneStructureSvgContainer\">` +\n        geneStructureSvg +\n      `</span>` +\n      `<div class=\"_ideoGeneStructureFooter\"></div>` +\n      `</div>`;\n\n  }\n  return geneStructureHtml;\n}\n","import {decompressSync, strFromU8} from 'fflate';\nimport { sortAnnotsByRank } from '../annotations/annotations';\n\n// Definitions for ArrowHead values in WikiPathways GPML\n//\n// See also: https://discover.nci.nih.gov/mim/formal_mim_spec.pdf\nconst interactionArrowMap = {\n  'Arrow': ['acts on', 'acted on by'],\n  'TBar': ['inhibits', 'inhibited by'],\n  'mim-binding': ['binds', 'binds'],\n  'mim-catalysis': ['catalyzes', 'catalyzed by'],\n  'mim-cleavage': ['cleaves', 'cleaved by'],\n  'mim-conversion': ['converts', 'converted by'],\n  // 'mim-covalent-bond': ['covalently binds',\n  'mim-gap': ['interacts with', 'interacts with'],\n  'mim-inhibition': ['inhibits', 'inhibited by'],\n  'mim-modification': ['modifies', 'modified by'],\n  'mim-necessary-stimulation':\n    ['necessarily stimulates', 'necessarily stimulated by'],\n  'mim-stimulation': ['stimulates', 'stimulated by'],\n  'mim-transcription-translation':\n    ['transcribes / translates', 'transcribed / translated by']\n};\n\n// Which interactions types to show first, if showing multiple\nconst rankedInteractionTypes = [\n  'transcribe',\n  'cleave',\n  'convert',\n  'bind',\n  'modifie',\n  'catalyze',\n  'necessarily stimulate',\n  'inhibit',\n  'stimulate',\n  'act'\n];\n\nexport function sortInteractionTypes(a, b) {\n  const ranks = {};\n  for (let i = 0; i < rankedInteractionTypes.length; i++) {\n    const rankedIxnType = rankedInteractionTypes[i];\n    if (rankedIxnType.includes(a)) ranks.a = i;\n    if (rankedIxnType.includes(b)) ranks.b = i;\n  }\n  return ranks.b - ranks.a;\n}\n\n/** Determine if all given interactions in *one* pathway are same */\nfunction determineIxnsInPathwayAreSame(ixns, ixnTypeReference) {\n  let isRefMatch = true;\n  let thisIsSame = true;\n\n  if (ixns.length === 0) return {isRefMatch, thisIsSame};\n\n  const thisIxnTypeReference = ixns[0].ixnType.toLowerCase();\n  ixns.forEach(ixn => {\n    const ixnType = ixn.ixnType.toLowerCase();\n    if (ixnType !== ixnTypeReference) {\n      isRefMatch = false;\n    }\n    if (ixnType !== thisIxnTypeReference) {\n      thisIsSame = false;\n    }\n  });\n  return {isRefMatch, thisIsSame};\n}\n\n/**\n * Return first valid interaction type from interactions-by-pathway object\n */\nfunction getIxnTypeReference(ixnsByPwid) {\n  const ixnTypeReference = Object.values(ixnsByPwid).find(ixns => {\n    return ixns.length > 0 && 'ixnType' in ixns[0];\n  })[0].ixnType.toLowerCase();\n\n  return ixnTypeReference;\n}\n\n/**\n * Determine whether all given interactions in all given pathways are the same\n */\nfunction setIsSame(enrichedIxns) {\n  let isSame = true;\n  const ixnsByPwid = enrichedIxns.ixnsByPwid;\n\n  const ixnTypeReference = getIxnTypeReference(ixnsByPwid);\n\n  Object.entries(ixnsByPwid).map(([pwid, ixns]) => {\n    const {isRefMatch, thisIsSame} =\n      determineIxnsInPathwayAreSame(ixns, ixnTypeReference);\n    if (!thisIsSame || !isRefMatch) {\n      isSame = false;\n    }\n    enrichedIxns.isSameByPwid[pwid] = thisIsSame;\n  });\n  enrichedIxns.isSame = isSame;\n\n  return enrichedIxns;\n}\n\n/**\n * If interactions aren't all exactly the same, then they are often still\n * directionally equivalent.\n *\n * E.g. if gene A both \"modifies\" and \"converts\" gene B, then we can summarize\n * that as gene A \"acts on\" gene B, rather than completely reverting to saying\n * gene A \"interacts with\" gene B.\n *\n */\nfunction summarizeByDirection(enrichedIxns) {\n\n  let isDirectionSame = true;\n\n  const leftTypes = []; // \"Acts on\" types\n  const rightTypes = []; // \"Acted on by\" types\n  Object.values(interactionArrowMap).forEach(directedTypes => {\n    rightTypes.push(directedTypes[0]);\n    leftTypes.push(directedTypes[1]);\n  });\n\n  const right = 'Acts on';\n  const left = 'Acted on by';\n\n  const ixnsByPwid = enrichedIxns.ixnsByPwid;\n  const firstIxnType = getIxnTypeReference(ixnsByPwid);\n  const isRight = rightTypes.includes(firstIxnType);\n  const directionReference = isRight ? right : left;\n\n  Object.entries(ixnsByPwid).map(([pwid, ixns]) => {\n    let isPwDirectionSame = true;\n    if (ixns.length > 0) {\n      const pwFirstIxnType = ixns[0].ixnType.toLowerCase();\n      const pwIsRight = rightTypes.includes(pwFirstIxnType);\n      const pwDirectionReference = pwIsRight ? right : left;\n      ixns.forEach(ixn => {\n        const ixnType = ixn.ixnType.toLowerCase();\n        const thisIsRight = rightTypes.includes(ixnType);\n        const direction = thisIsRight ? right : left;\n        enrichedIxns.directionsByPwid[pwid] = direction;\n        if (direction !== directionReference) {\n          isDirectionSame = false;\n        }\n        if (direction !== pwDirectionReference) {\n          isPwDirectionSame = false;\n        }\n      });\n    }\n    enrichedIxns.isDirectionSameByPwid[pwid] = isPwDirectionSame;\n\n  });\n\n  enrichedIxns.isDirectionSame = isDirectionSame;\n  if (isDirectionSame === true) {\n    enrichedIxns.direction = directionReference;\n  }\n\n  return enrichedIxns;\n}\n\n/**\n * Summarize interactions by direction\n *\n * @param {String} gene Interacting gene\n * @param {String} searchedGene Searched gene\n * @param {Array} pathwayIds List of WikiPathways IDs\n * @param {Object} gpmls Object of parsed GPML XMLs values, by pathway ID key\n * @returns\n */\nexport function summarizeInteractions(gene, searchedGene, pathwayIds, gpmls) {\n  let summary = null;\n\n  // Coarse interactions are cached offline, so if not connected to Internet\n  // then fallback to generic summary.\n  if (!navigator.onLine) return 'Interacts with';\n\n  const ixnsByPwid =\n    detailAllInteractions(gene, searchedGene, pathwayIds, gpmls);\n\n  const ixns = ixnsByPwid[pathwayIds[0]];\n\n  if (ixns.length > 0) {\n    let enrichedIxns = {\n      ixnsByPwid,\n      isSameByPwid: {}, // If pathway has all same interaction types\n      isSame: null, // If above is true for all pathways\n      isDirectionSameByPwid: {}, // If pathway has same ixn direction\n      isDirectionSame: null, // If above is true for all pathways\n      directionsByPwid: {}\n    };\n    enrichedIxns = setIsSame(enrichedIxns);\n\n    if (enrichedIxns.isSame) {\n      const ixnType = ixns[0].ixnType;\n      const newIxn = ixnType;\n      summary = newIxn;\n    } else {\n\n      enrichedIxns = summarizeByDirection(enrichedIxns);\n\n      if (enrichedIxns.isDirectionSame) {\n        summary = enrichedIxns.direction;\n      } else {\n        summary = 'Interacts with';\n      }\n    }\n  }\n\n\n    // if (direction !== null) {\n    //   summary = direction;\n    // }\n    // const pwidsByIxnType = {};\n    // Object.entries(ixns).map(([k, v]) => {\n    //   if (!pwidsByIxnType[v.ixnType]) {\n    //     pwidsByIxnType[v.ixnType] = [v.pathwayId];\n    //   } else {\n    //     pwidsByIxnType[v.ixnType].push([v.pathwayId]);\n    //   }\n    // });\n\n    // console.log('pwidsByIxnType')\n    // console.log(pwidsByIxnType)\n    // const tpArray = Object.entries(pwidsByIxnType);\n    // const sortedIndices = sortInteractionTypes(tpArray.map(tp => tp[0]));\n    // const sortedTpArray =\n    //   sortedIndices.map(sortedIndex => tpArray[sortedIndex]);\n\n    // console.log('sortedTpArray')\n    // console.log(sortedTpArray)\n  return summary;\n}\n\n/**\n * Get detailInteractions results for multiple pathways\n *\n * @param gene Interacting gene\n * @param pathwayIds List of WikiPathways IDs\n * @ideo ideo Ideogram instance object\n */\nexport function detailAllInteractions(gene, searchedGene, pathwayIds, gpmls) {\n  const ixnsByPwid = {};\n\n  pathwayIds.map(pathwayId => {\n    const gpml = gpmls[pathwayId];\n    const ixns = detailInteractions(gene, searchedGene, gpml);\n\n    ixnsByPwid[pathwayId] = ixns;\n  });\n  return ixnsByPwid;\n}\n\n/** Get IDs and data element objects for searched or interacting gene */\nfunction getMatches(gpml, label) {\n\n  const nodes = Array.from(gpml.querySelectorAll(\n    `DataNode[TextLabel=\"${label}\"]`\n  ));\n\n  const genes = nodes.map(node => {\n    return {\n      type: 'node',\n      matchedLabel: label,\n      textLabel: node.getAttribute('TextLabel'),\n      graphId: node.getAttribute('GraphId'),\n      groupRef: node.getAttribute('GroupRef')\n    };\n  });\n\n  // Get group identifiers\n  const geneGraphIds = genes.map(g => g.graphId);\n  const geneGroupRefs = genes.map(g => g.groupRef);\n  const groupSelectors =\n    geneGroupRefs.map(ggr => `Group[GroupId=\"${ggr}\"]`).join(',');\n\n  let geneGroups = [];\n  if (groupSelectors !== '') {\n    const groups = gpml.querySelectorAll(groupSelectors);\n    geneGroups = Array.from(groups).map(group => {\n      return {\n        type: 'group',\n        matchedLabel: label,\n        graphId: group.getAttribute('GraphId'),\n        groupId: group.getAttribute('GroupId')\n      };\n    });\n  }\n\n  const geneGroupGraphIds = geneGroups.map(g => g.graphId);\n  const matchingGraphIds = geneGraphIds.concat(geneGroupGraphIds);\n\n  const elements = genes.concat(geneGroups);\n\n  return [matchingGraphIds, elements];\n}\n\nasync function fetchGpml(pathwayId) {\n  const pathwayFile = `${pathwayId}.xml.gz`;\n  const gpmlUrl = `https://cdn.jsdelivr.net/npm/ixn2/${pathwayFile}`;\n  const response = await fetch(gpmlUrl);\n  const blob = await response.blob();\n  const uint8Array = new Uint8Array(await blob.arrayBuffer());\n  const rawGpml = strFromU8(decompressSync(uint8Array));\n\n  const gpml = new DOMParser().parseFromString(rawGpml, 'text/xml');\n\n  // console.log('gpml:')\n  // console.log(gpml)\n\n  return gpml;\n}\n\n/**\n * Request compressed GPML files, which contain detailed interaction data, e.g.\n * https://cdn.jsdelivr.net/npm/ixn/WP3982.xml.gz\n *\n * For more easily readable versions, see also:\n * - https://www.wikipathways.org/index.php?title=Pathway:WP3982&action=edit\n * - https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=gpml&pwTitle=Pathway:WP3982\n *\n * GPML (Graphical Pathway Markup Language) data encodes detailed interaction\n * data for biochemical pathways.\n */\nexport function fetchGpmls(ideo) {\n\n  const pathwayIdsByInteractingGene = {};\n  Object.entries(ideo.annotDescriptions.annots)\n    .forEach(([annotName, descObj]) => {\n      if ('type' in descObj && descObj.type.includes('interacting gene')) {\n        pathwayIdsByInteractingGene[annotName] = descObj.pathwayIds;\n      }\n    });\n\n  const gpmlsByInteractingGene = {};\n  Object.entries(pathwayIdsByInteractingGene)\n    .forEach(([ixnGene, pathwayIds]) => {\n      gpmlsByInteractingGene[ixnGene] = {};\n      pathwayIds.map(async pathwayId => {\n        const gpml = await fetchGpml(pathwayId);\n        gpmlsByInteractingGene[ixnGene][pathwayId] = gpml;\n      });\n    });\n\n  ideo.gpmlsByInteractingGene = gpmlsByInteractingGene;\n}\n\n/**\n * Get interaction object from a GPML graphics XML element\n *\n * This interaction object connects the searched gene and interacting gene.\n */\nfunction parseInteractionGraphic(graphic, graphIds) {\n  let interaction = null;\n\n  const {searchedGeneGraphIds, matchingGraphIds} = graphIds;\n\n  const endGraphRefs = [];\n  let numMatchingPoints = 0;\n  let isConnectedToSourceGene = false;\n  let ixnType = null;\n  let searchedGeneIndex = null;\n\n  Array.from(graphic.children).forEach(child => {\n    if (child.nodeName !== 'Point') return;\n    const point = child;\n    const graphRef = point.getAttribute('GraphRef');\n    if (graphRef === null) return;\n\n    if (matchingGraphIds.includes(graphRef)) {\n      numMatchingPoints += 1;\n      endGraphRefs.push(graphRef);\n\n      if (searchedGeneGraphIds.includes(graphRef)) {\n        isConnectedToSourceGene = true;\n      }\n\n      if (point.getAttribute('ArrowHead')) {\n        const arrowHead = point.getAttribute('ArrowHead');\n        const isStart = searchedGeneGraphIds.includes(graphRef);\n        if (searchedGeneIndex === null) {\n          searchedGeneIndex = isStart ? 0 : 1;\n        }\n        ixnType = interactionArrowMap[arrowHead][isStart ? 0 : 1];\n      }\n    }\n  });\n\n  if (numMatchingPoints >= 2 && isConnectedToSourceGene) {\n    if (searchedGeneIndex === null) {\n      ixnType = 'interacts with';\n    }\n    ixnType = ixnType[0].toUpperCase() + ixnType.slice(1);\n    const interactionGraphId = graphic.parentNode.getAttribute('GraphId');\n    interaction = {\n      'interactionId': interactionGraphId,\n      'endIds': endGraphRefs,\n      ixnType\n    };\n  }\n\n  return interaction;\n}\n\n/**\n * Get all genes in the given pathway GPML\n */\nexport async function fetchPathwayInteractions(searchedGene, pathwayId, ideo) {\n  const gpml = await fetchGpml(pathwayId);\n  // Gets IDs and elements for searched gene and interacting gene, and,\n  // if they're in any groups, the IDs of those groups\n  const genes = {};\n\n  const nodes = Array.from(gpml.querySelectorAll('DataNode'));\n  nodes.forEach(node => {\n    const label = node.getAttribute('TextLabel');\n    const normLabel = label.toLowerCase();\n    const isKnownGene = normLabel in ideo.geneCache.nameCaseMap;\n    if (isKnownGene) {\n      genes[label] = 1;\n    }\n  });\n\n  const pathwayGenes = Object.keys(genes);\n  const pathwayIxns = {};\n  pathwayGenes.map(gene => {\n    if (gene === searchedGene) return;\n    const gpmls = {};\n    gpmls[pathwayId] = gpml;\n    const summary = summarizeInteractions(\n      gene, searchedGene, [pathwayId], gpmls\n    );\n    pathwayIxns[gene] = (summary ? summary : 'Shares pathway with');\n  });\n\n  return pathwayIxns;\n}\n\n/**\n * Fetch GPML for pathway and find ID of Interaction between two genes,\n * and the ID of the two DataNodes for each of those interactions.\n *\n * WikiPathways SVG isn't detailed enough to reliably determine the specific\n * interaction elements relating two genes, given only the gene symbols.  This\n * fetches augmented GPML data for the pathway, and queries it to get only\n * interactions between the two genes.\n */\nfunction detailInteractions(interactingGene, searchedGene, gpml) {\n\n  // Gets IDs and elements for searched gene and interacting gene, and,\n  // if they're in any groups, the IDs of those groups\n  const [searchedGeneGraphIds, se] = getMatches(gpml, searchedGene);\n  const [interactingGeneGraphIds, ie] = getMatches(gpml, interactingGene);\n\n  const elements = {\n    searchedGene: se,\n    interactingGene: ie\n  };\n\n  const matchingGraphIds =\n    searchedGeneGraphIds.concat(interactingGeneGraphIds);\n  const graphIds = {searchedGeneGraphIds, matchingGraphIds};\n\n  // Get interaction objects that connect the searched and interacting genes\n  const interactions = [];\n  const graphicsXml = gpml.querySelectorAll('Interaction Graphics');\n  Array.from(graphicsXml).forEach(graphic => {\n    const interaction = parseInteractionGraphic(graphic, graphIds);\n    if (interaction !== null) {\n      interaction.elements = elements;\n      interactions.push(interaction);\n    }\n  });\n\n  return interactions;\n}\n\n// export async function fetchInteractionDiagram(annot, descObj, ideo) {\n//   // Fetch raw SVG for pathway diagram\n//   const pathwayId = descObj.pathwayIds[0];\n//   // const baseUrl = 'https://eweitz.github.io/cachome/wikipathways/';\n//   const baseUrl = 'https://cachome.github.io/wikipathways/';\n//   // const baseUrl = 'http://localhost/wikipathways/data/';\n//   const diagramUrl = baseUrl + pathwayId + '.svg';\n//   const response = await fetch(diagramUrl);\n//   if (response.ok) {\n\n//     // console.log('searchedGene', searchedGene)\n\n//     const ixns = await detailInteractions(annot.name, pathwayId, ideo);\n\n//     let selectors = `[name=${annot.name}]`;\n//     let searchedGeneIndex = 0;\n//     let interactingGeneIndex;\n//     if (ixns.length > 0) {\n//       selectors = ixns[0].endIds.map(id => '#' + id).join(',');\n//       searchedGeneIndex = ixns[0].searchedGeneIndex;\n//       interactingGeneIndex = (searchedGeneIndex === 0) ? 1 : 0;\n//     }\n//     // https://webservice.wikipathways.org/findInteractions?query=ACE2&format=json\n\n//     const rawDiagram = await response.text();\n\n//     const pathwayDiagram =\n//       `<div class=\"pathway-diagram\">${rawDiagram}</div>`;\n\n//     annot.displayName += pathwayDiagram;\n\n//     document.querySelector('#_ideogramTooltip').innerHTML =\n//       annot.displayName;\n\n//     Ideogram.d3.select('svg.Diagram')\n//       .attr('width', 350)\n//       .attr('height', 300);\n\n//     const viewport = document.querySelector('.svg-pan-zoom_viewport');\n//     viewport.removeAttribute('style');\n//     viewport.removeAttribute('transform');\n\n//     const matches = document.querySelectorAll(selectors);\n//     console.log('matches', matches)\n//     const match0 = matches[searchedGeneIndex]\n//     const m0 = match0.getCTM();\n//     const m0Rect = match0.getBoundingClientRect();\n//     const m0Box = match0.getBBox();\n//     const m0MinX = m0.e/m0.a;\n//     const m0MinY = m0.f/m0.d;\n\n//     let minX = m0MinX;\n//     let minY = m0MinY;\n//     let width;\n//     let height;\n\n//     width = 350;\n//     height = 300;\n\n//     // matches[0].children[0].setAttribute('fill', '#F55');\n//     match0.children[0].style.fill = '#f55';\n\n//     if (matches.length > 1) {\n//       // console.log('matches.length > 1')\n//       // matches[1].children[0].setAttribute('fill', '#C4C');\n//       const match1 = matches[interactingGeneIndex];\n//       // console.log('match1')\n//       // console.log(match1)\n//       match1.children[0].style.fill = '#c4c';\n//       const m1 = matches[1].getCTM();\n//       const m1Rect = matches[1].getBoundingClientRect();\n//       const m1Box = matches[1].getBBox();\n//       console.log('m0', m0)\n//       console.log('m1', m1)\n//       const m1MinX = m1.e/m1.a;\n//       const m1MinY = m1.f/m1.d;\n//       // const m1MinX = m1.e/m1.a + m1Rect.width;\n//       // const m1MinY = m1.f/m1.d - m1Rect.height;\n//       if (m1MinX < m0MinX) minX = m1MinX;\n//       if (m1MinY < m0MinY) minY = m1MinY;\n\n//       let pairWidth = 0;\n//       if (m0Rect.left < m1Rect.left) {\n//         // pairWidth = m1Rect.right - m0Rect.left;\n//         width += m1Box.width + 40;\n//       }\n\n//       // width += pairWidth;\n\n//       // console.log('m0Rect', m0Rect)\n//       // console.log('m1Rect', m1Rect)\n//       // console.log('m1MinX', m1MinX)\n//       // console.log('m0MinX', m0MinX)\n//       // console.log('m1MinY', m1MinY)\n//       // console.log('m0MinY', m0MinY)\n//       // console.log('pairWidth', pairWidth)\n//       // console.log('width', width)\n//       // width += Math.abs(m1MinX - m0MinX);\n//       // height += Math.abs(m1MinY - m0MinY);\n\n//       // minX -= 100;\n//       // minY -= 100;\n\n//       // minX -= 150;\n//       // minY -= 150;\n//     } else {\n//       minX -= 150;\n//       minY -= 150;\n//     }\n\n//     minX = Math.round(minX);\n//     minY = Math.round(minY);\n//     width = Math.round(width);\n//     height = Math.round(height);\n\n//     const viewBox = `${minX} ${minY} ${width} ${height}`;\n//     console.log('viewBox', viewBox);\n//     document.querySelector('svg.Diagram').setAttribute('viewBox', viewBox);\n\n//   }\n// }\n","/**\n * @fileoverview Kit used in \"Related genes\" example\n *\n * This file simplifies client code for reusing a \"related genes\" ideogram --\n * which finds and displays related genes for a searched gene.\n *\n * Related genes here are either \"interacting genes\" or \"paralogs\".\n * Interacting genes are genes immediately upstream or downstream of the\n * searched gene in a biochemical pathway. Paralogs are evolutionarily\n * similar genes in the same species.\n *\n * Data sources:\n *   - Interacting genes: WikiPathways\n *   - Paralogs: Ensembl\n *   - Genomic coordinates: Ensembl, via MyGene.info\n *\n * Features provided by this module help users discover and explore genes\n * related to their gene of interest.\n *\n * The reference implementation is available at:\n * https://eweitz.github.io/ideogram/related-genes\n */\n\nimport {decompressSync, strFromU8} from 'fflate';\n\nimport {\n  initAnalyzeRelatedGenes, analyzePlotTimes, analyzeRelatedGenes, timeDiff,\n  getRelatedGenesByType, getRelatedGenesTooltipAnalytics\n} from './analyze-related-genes';\nimport {\n  getGeneStructureHtml, addGeneStructureListeners\n} from './gene-structure';\n\nimport {\n  sortAnnotsByRank, applyRankCutoff, setAnnotRanks,\n} from '../annotations/annotations';\nimport {writeLegend} from '../annotations/legend';\nimport {getAnnotDomId} from '../annotations/process';\nimport {getDir, deepCopy, slug} from '../lib';\nimport {\n  fetchGpmls, summarizeInteractions, fetchPathwayInteractions\n} from './wikipathways';\n// import {drawAnnotsByLayoutType} from '../annotations/draw';\n// import {organismMetadata} from '../init/organism-metadata';\n\n/** Sets DOM IDs for ideo.relatedAnnots; needed to associate labels */\nfunction setRelatedAnnotDomIds(ideo) {\n  const updated = [];\n\n  const sortedChrNames = ideo.chromosomesArray.map((chr) => {\n    return chr.name;\n  });\n\n  ideo.relatedAnnots = applyAnnotsIncludeList(ideo.relatedAnnots, ideo);\n\n  // Count two related annots for same gene as one.\n  // E.g. gene Foo can both interact with and be paralog of gene Bar\n  // Instead of count Foo interacting annot and Foo paralog annot as two,\n  // only count it as one as they are merged in downstream UI.\n  //\n  // Searching STAT3 without this block shows the problem this fixes.\n  const seenNames = {};\n  ideo.relatedAnnots = ideo.relatedAnnots.filter(annot => {\n    if (annot.name in seenNames) {\n      return false;\n    }\n    seenNames[annot.name] = 1;\n    return true;\n  });\n\n  // Arrange related annots by chromosome\n  const annotsByChr = {};\n  ideo.relatedAnnots.forEach((annot) => {\n    if (annot.chr in annotsByChr) {\n      annotsByChr[annot.chr].push(annot);\n    } else {\n      annotsByChr[annot.chr] = [annot];\n    }\n  });\n\n  // Sort related annots by relevance within each chromosome\n  const relevanceSortedAnnotsNamesByChr = {};\n  Object.entries(annotsByChr).map(([chr, annots]) => {\n\n    annots = setAnnotRanks(annots, ideo);\n\n    // Sort so first annots are drawn last, and thus at top layer\n    annots.sort((a, b) => -ideo.annotSortFunction(a, b));\n\n    const annotNames = annots.map((annot) => annot.name);\n    relevanceSortedAnnotsNamesByChr[chr] = annotNames;\n  });\n\n  // annotsByChr.annots.sort((a, b) => {\n  //   // Reverse-sort, so first annots are drawn last, and thus at top layer\n  //   return -ideo.annotSortFunction(a, b);\n  // });\n\n  ideo.relatedAnnots.forEach((annot) => {\n\n    const chr = annot.chr;\n\n    // Annots have DOM IDs keyed by chromosome index and annotation index.\n    // We reconstruct those here using structures built in two blocks above.\n    const chrIndex = sortedChrNames.indexOf(chr);\n    const annotIndex =\n      relevanceSortedAnnotsNamesByChr[chr].indexOf(annot.name);\n\n    annot.domId = getAnnotDomId(chrIndex, annotIndex);\n    updated.push(annot);\n  });\n\n  ideo.relatedAnnots = updated;\n}\n\n/**\n * Determines if interaction node might be a gene\n *\n * Some interaction nodes are biological processes; this filters out many.\n * Filtering these out makes downstream queries faster.\n *\n * ixn {Object} Interaction from WikiPathways\n * gene {Object} Gene from MyGene.info\n */\nfunction maybeGeneSymbol(ixn, gene) {\n  return (\n    ixn !== '' &&\n    !ixn.includes(' ') &&\n    !ixn.includes('/') && // e.g. Akt/PKB\n    ixn.toLowerCase() !== gene.name.toLowerCase()\n  );\n}\n\n// /** Helpful for debugging race conditions caused by concurrency */\n// const sleep = (delay) => {\n//  new Promise((resolve) => setTimeout(resolve, delay));\n// }\n\n/** Reports if interaction node is a gene and not previously seen */\nfunction isInteractionRelevant(rawIxn, gene, nameId, seenNameIds, ideo) {\n  let isGeneSymbol;\n  if ('geneCache' in ideo && gene.name) {\n    isGeneSymbol = rawIxn.toLowerCase() in ideo.geneCache.nameCaseMap;\n  } else {\n    isGeneSymbol = maybeGeneSymbol(rawIxn, gene);\n  }\n\n  return isGeneSymbol && !(nameId in seenNameIds);\n}\n\n/**\n * Retrieves interacting genes from WikiPathways API\n *\n * Docs:\n * https://webservice.wikipathways.org/ui/\n * https://www.wikipathways.org/index.php/Help:WikiPathways_Webservice/API\n *\n * Examples:\n * https://webservice.wikipathways.org/findInteractions?query=ACE2&format=json\n * https://webservice.wikipathways.org/findInteractions?query=RAD51&format=json\n */\nasync function fetchInteractions(gene, ideo) {\n  const ixns = {};\n  const seenNameIds = {};\n  const orgNameSimple = ideo.config.organism.replace(/-/g, ' ');\n  const upperGene = gene.name.toUpperCase();\n\n  let data = {result: []};\n\n  if (ideo.interactionCache) {\n    if (upperGene in ideo.interactionCache) {\n      data = ideo.interactionCache[upperGene];\n    }\n  } else {\n\n    // const queryString = `?query=${gene.name}&format=json`;\n    // const url =\n    //   `https://webservice.wikipathways.org/findInteractions${queryString}`;\n    // const url = `http://localhost:8080/dist/data/cache/${gene.name}.json.gz`;\n    const url = `https://cdn.jsdelivr.net/npm/ixn2/${upperGene}.json.gz`;\n\n    // await sleep(3000);\n\n    const response = await fetch(url);\n    // const data = await response.json();\n\n    if (response.ok) {\n      const blob = await response.blob();\n      const uint8Array = new Uint8Array(await blob.arrayBuffer());\n      data = JSON.parse(strFromU8(decompressSync(uint8Array)));\n    }\n  }\n\n  // For each interaction, get nodes immediately upstream and downstream.\n  // Filter out pathway nodes that are definitely not gene symbols, then\n  // group pathways by gene symbol. Each interacting gene can have\n  // multiple pathways.\n  data.result.forEach(interaction => {\n    if (interaction.species.toLowerCase() === orgNameSimple) {\n      const right = interaction.fields.right.values;\n      const left = interaction.fields.left.values;\n      // let mediator = [];\n      // if ('mediator' in interaction.fields) {\n      //   mediator = interaction.fields.mediator.values;\n      //   console.log('mediator', mediator)\n      // }\n      // const rawIxns = right.concat(left, mediator);\n      const rawIxns = right.concat(left);\n      const name = interaction.name;\n      const id = interaction.id;\n\n      // rawIxns can contain multiple genes, e.g. when\n      // a group (i.e. a complex or a set of paralogs)\n      // interacts with the searched gene\n      const wrappedRawIxns = rawIxns.map(rawIxn => {\n        return {name: rawIxn, color: ''};\n      });\n      const sortedRawIxns =\n        sortAnnotsByRank(wrappedRawIxns, ideo).map(i => i.name);\n\n      sortedRawIxns.forEach(rawIxn => {\n\n        const normRawIxn = rawIxn.toLowerCase();\n\n        // Prevent overwriting searched gene.  Occurs with e.g. human CD4\n        if (normRawIxn.includes(gene.name.toLowerCase())) return;\n\n        // if (rawIxn === '') return; // Avoid oddly blank placeholders\n\n        const nameId = name + id;\n\n        const isRelevant =\n          isInteractionRelevant(normRawIxn, gene, nameId, seenNameIds, ideo);\n\n        if (isRelevant) {\n          seenNameIds[nameId] = 1;\n          const ixn = {name, pathwayId: id};\n          if (normRawIxn in ixns) {\n            ixns[normRawIxn].push(ixn);\n          } else {\n            ixns[normRawIxn] = [ixn];\n          }\n        }\n      });\n    }\n  });\n\n  return ixns;\n}\n\n/**\n * Queries MyGene.info API, returns parsed JSON\n *\n * Docs:\n * https://docs.mygene.info/en/v3/\n *\n * Example:\n * https://mygene.info/v3/query?q=symbol:cdk2%20OR%20symbol:brca1&species=9606&fields=symbol,genomic_pos,name\n */\nasync function fetchMyGeneInfo(queryString) {\n  const myGeneBase = 'https://mygene.info/v3/query';\n  const response = await fetch(myGeneBase + queryString + '&size=400');\n  const data = await response.json();\n  return data;\n}\n\nfunction parseNameAndEnsemblIdFromMgiGene(gene) {\n  const name = gene.name;\n  const id = gene.genomic_pos.ensemblgene;\n  let ensemblId = id;\n  if (typeof id === 'undefined') {\n    // Encountered in AKT3, when querying related genes for MTOR\n    // A 'chr'omosome value containing _ indicates an alt loci scaffold,\n    // so ignore that and take the Ensembl ID associated with the\n    // first position of a primary chromosome.\n    ensemblId =\n      gene.genomic_pos.filter(pos => !pos.chr.includes('_'))[0].ensemblgene;\n  }\n  return {name, ensemblId};\n}\n\n// /**\n//  * Summarizes genes in a pathway\n//  *\n//  * This comprises most of the content for tooltips for pathway genes.\n//  */\n//  function describePathwayGene(pathwayGene, searchedGene, pathway, summary) {\n//   let ixnsDescription = '';\n\n//   const pathwaysBase = 'https://www.wikipathways.org/index.php/Pathway:';\n//   const url = `${pathwaysBase}${pathway.id}`;\n//   const attrs =\n//     `href=\"${url}\" ` +\n//     `target=\"_blank\" ` +\n//     `title=\"See pathway diagram in WikiPathways\"`;\n//   ixnsDescription =\n//     `${summary} ${searchedGene.name} in:</br/>` +\n//     `<a ${attrs}>${pathway.name}</a>`;\n\n//   const {name, ensemblId} = parseNameAndEnsemblIdFromMgiGene(pathwayGene);\n//   const type = 'pathway gene';\n//   const descriptionObj = {\n//     description: ixnsDescription,\n//     ixnsDescription, ensemblId, name, type\n//   };\n//   return descriptionObj;\n// }\n\n/**\n * Summarizes interactions for a gene\n *\n * This comprises most of the content for tooltips for interacting genes.\n */\nfunction describeInteractions(gene, ixns, searchedGene) {\n  const pathwayIds = [];\n  const pathwayNames = [];\n  let ixnsDescription = '';\n\n  if (typeof ixns !== 'undefined') {\n    // ixns is undefined when querying e.g. CDKN1B in human\n    const links = ixns.map(ixn => {\n      // pathwayIds.push(ixn.pathwayId);\n      // pathwayNames.push(ixn.name);\n      // const attrs =\n      //   `class=\"ideo-pathway-link\" ` +\n      //   `title=\"Click to search for other genes in this pathway\" ` +\n      //   `style=\"cursor: pointer\" ` +\n      //   `data-pathway-id=\"${ixn.pathwayId}\" ` +\n      //   `data-pathway-name=\"${ixn.name}\"`;\n      // return `<a ${attrs}>${ixn.name}</a>`;\n\n      const pathwaysBase = 'https://www.wikipathways.org/index.php/Pathway:';\n      const url = `${pathwaysBase}${ixn.pathwayId}`;\n      pathwayIds.push(ixn.pathwayId);\n      pathwayNames.push(ixn.name);\n      const attrs =\n        `class=\"ideo-pathway-link\" ` +\n        `title=\"View in WikiPathways\" ` +\n        `data-pathway-id=\"${ixn.pathwayId}\" ` +\n        `target=\"_blank\" ` +\n        `href=\"${url}\"`;\n      return `<a ${attrs}>${ixn.name}</a>`;\n    }).join('<br/>');\n\n    ixnsDescription =\n      `Interacts with ${searchedGene.name} in:<br/>${links}`;\n  }\n\n  const {name, ensemblId} = parseNameAndEnsemblIdFromMgiGene(gene);\n  const type = 'interacting gene';\n  const descriptionObj = {\n    description: ixnsDescription,\n    ixnsDescription, ensemblId, name, type, pathwayIds, pathwayNames\n  };\n  return descriptionObj;\n}\n\n/** Throw error when searched gene (e.g. \"Foo\") isn't found */\nfunction throwGeneNotFound(geneSymbol, ideo) {\n  const organism = ideo.organismScientificName;\n  throw Error(`\"${geneSymbol}\" is not a known gene in ${organism}`);\n}\n\n/**\n * Fetch genes from cache\n * Construct objects that match format of MyGene.info API response\n */\nfunction fetchGenesFromCache(names, type, ideo) {\n  const cache = ideo.geneCache;\n  const isSymbol = (type === 'symbol');\n  const locusMap = isSymbol ? cache.lociByName : cache.lociById;\n  const nameMap = isSymbol ? cache.idsByName : cache.namesById;\n\n  const hits = names.map(name => {\n\n    const nameLc = name.toLowerCase();\n\n    if (!locusMap[name] && !cache.nameCaseMap[nameLc]) {\n      if (isSymbol) {\n        throwGeneNotFound(name, ideo);\n      } else {\n        return;\n      }\n    }\n\n    // Canonicalize name if it is mistaken in upstream data source.\n    // This can sometimes happen in WikiPathways, e.g. when searching\n    // interactions for rat Pten, it includes a result for \"PIK3CA\".\n    // In that case, this would correct PIK3CA to be Pik3ca.\n    if (isSymbol && !locusMap[name] && cache.nameCaseMap[nameLc]) {\n      name = cache.nameCaseMap[nameLc];\n    }\n\n    const locus = locusMap[name];\n    const symbol = isSymbol ? name : nameMap[name];\n    const ensemblId = isSymbol ? nameMap[name] : name;\n    const fullName = cache.fullNamesById[ensemblId];\n\n    const hit = {\n      symbol,\n      name: fullName,\n      source: 'cache',\n      genomic_pos: {\n        chr: locus[0],\n        start: locus[1],\n        end: locus[2],\n        ensemblgene: ensemblId\n      }\n    };\n\n    return hit;\n  });\n\n  const hitsWithGenomicPos = hits.filter(hit => hit !== undefined);\n\n  return hitsWithGenomicPos;\n}\n\n/** Wait for a certain time (delay) in milliseconds */\nfunction wait(delay) {\n  return new Promise((resolve) => setTimeout(resolve, delay));\n}\n\n/**\n * Get time to wait before retrying a fail service, gracefully\n *\n * The returned wait time helps avoid flooding the server\n */\nfunction exponentialBackoffWithJitter(numFailures, baseWaitMs) {\n  const jitter = 10 * Math.random();\n  return Math.round(baseWaitMs + jitter) * (numFailures ** 2);\n}\n\nasync function retryFetch(requestedThing, numLimit, fn, args) {\n\n  const numFailed = numFailedFetches[requestedThing];\n  if (numFailed > numLimit) {\n    const preamble = 'Failed to fetch from Ideogram third-party service for: ';\n    throw new TypeError(preamble + requestedThing);\n  }\n\n  numFailedFetches[requestedThing] += 1;\n\n  // Exponential backoff\n  const baseWaitMs = 500;\n  const waitMilliseconds = exponentialBackoffWithJitter(numFailed, baseWaitMs);\n\n  console.log(\n    `Failed fetch for ${requestedThing} ${numFailed} times, ` +\n    `retrying in ${waitMilliseconds} ms`\n  );\n\n  await wait(waitMilliseconds);\n  return await fn(...args);\n}\n\n/** Number of times fetches for various things have consecutively failed */\nconst numFailedFetches = {\n  genes: 0\n};\n\n/** Fetch genes from cache, or, if needed, from MyGene.info API */\nasync function fetchGenes(names, type, ideo) {\n\n  let data;\n\n  // Account for single-gene fetch\n  if (typeof names === 'string') names = [names];\n\n  // Query parameter for MyGene.info API\n  const qParam = names.map(name => `${type}:${name.trim()}`).join(' OR ');\n  const taxid = ideo.config.taxid;\n\n  const queryStringBase = `?q=${qParam}&species=${taxid}&fields=`;\n\n  if (ideo.geneCache) {\n    const hits = fetchGenesFromCache(names, type, ideo);\n\n    // Asynchronously fetch full name, but don't await the response, because\n    // full names are only shown upon hovering over an annotation.\n    hits.forEach((hit) => {\n      const symbol = hit.symbol;\n      const fullName = hit.name;\n      if (symbol in ideo.annotDescriptions.annots) {\n        ideo.annotDescriptions.annots[symbol].name = fullName;\n      } else {\n        ideo.annotDescriptions.annots[symbol] = {name: fullName};\n      }\n    });\n\n    data = {hits, fromGeneCache: true};\n  } else {\n    // Fetch gene data from MyGene.info\n    const queryString = `${queryStringBase}symbol,genomic_pos,name`;\n    try {\n      data = await fetchMyGeneInfo(queryString);\n    } catch (error) {\n      const isFailedFetch = (error.message === 'Failed to fetch');\n      if (isFailedFetch && navigator.onLine) {\n        // Retry fetching 3 times, waiting longer each time\n        data = await retryFetch('genes', 3, fetchGenes, [names, type, ideo]);\n      }\n    }\n  }\n\n  return data;\n}\n\n/**\n * Retrieves position and other data on interacting genes from MyGene.info\n */\nasync function fetchInteractionAnnots(interactions, searchedGene, ideo) {\n\n  const annots = [];\n  const symbols = Object.keys(interactions);\n\n  if (symbols.length === 0) return annots;\n\n  const data = await fetchGenes(symbols, 'symbol', ideo);\n\n  data.hits.forEach(gene => {\n    // If hit lacks position\n    // or is same as searched gene (e.g. search for human SRC),\n    // then skip processing\n    if (\n      'genomic_pos' in gene === false ||\n      gene.symbol === searchedGene.name\n    ) {\n      return;\n    }\n\n    const annot = parseAnnotFromMgiGene(gene, ideo, 'purple');\n    annots.push(annot);\n\n    const ixns = interactions[gene.symbol.toLowerCase()];\n\n    const descriptionObj = describeInteractions(gene, ixns, searchedGene);\n\n    mergeDescriptions(annot, descriptionObj, ideo);\n  });\n\n  // Fetch GPML files to use when updating interaction descriptions with\n  // refined direction.\n  fetchGpmls(ideo);\n\n  return annots;\n}\n\n/** Fetch paralog positions from MyGeneInfo */\nasync function fetchParalogPositionsFromMyGeneInfo(\n  homologs, searchedGene, ideo\n) {\n  const annots = [];\n\n  const cached = homologs.length && typeof homologs[0] === 'string';\n  const ensemblIds = cached ? homologs : homologs.map(homolog => homolog.id);\n  const data = await fetchGenes(ensemblIds, 'ensemblgene', ideo);\n\n  data.hits.forEach(gene => {\n\n    // If hit lacks position, skip processing\n    if ('genomic_pos' in gene === false) return;\n    if ('name' in gene === false) return;\n\n    const annot = parseAnnotFromMgiGene(gene, ideo, 'pink');\n    annots.push(annot);\n\n    const description = `Paralog of ${searchedGene.name}`;\n    const {name, ensemblId} = parseNameAndEnsemblIdFromMgiGene(gene);\n    const type = 'paralogous gene';\n    const descriptionObj = {description, ensemblId, name, type};\n    mergeDescriptions(annot, descriptionObj, ideo);\n  });\n\n  return annots;\n}\n\nfunction overplotParalogs(annots, ideo) {\n  if (!ideo.config.showParalogNeighborhoods) return;\n\n  annots = applyAnnotsIncludeList(annots, ideo);\n\n  if (annots.length < 2) return;\n\n  // Arrays of paralogs within 10 Mbp of each other\n  const neighborhoods = {};\n\n  neighborhoods[annots[0].chr] = {};\n  neighborhoods[annots[0].chr][annots[0].start] = [annots[0]];\n\n  const windowInt = 2_000_000;\n  const windowProse = '2 Mbp';\n\n  for (let i = 1; i < annots.length; i++) {\n    const annot = annots[i];\n    const chr = annot.chr;\n    const start = annot.start;\n    if (chr in neighborhoods) {\n      const starts = Object.keys(neighborhoods[chr]);\n      for (let j = 0; j < starts.length; j++) {\n        const startJInt = parseInt(starts[j]);\n        if (Math.abs(start - startJInt) < windowInt) {\n          neighborhoods[chr][startJInt].push(annot);\n        } else {\n          neighborhoods[chr][start] = [annot];\n        }\n      }\n    } else {\n      neighborhoods[chr] = {};\n      neighborhoods[chr][start] = [annot];\n    }\n  }\n\n  // Big enough to see and hover\n  const overlayAnnotLength = 15_000_000;\n\n  const searchedGene = getSearchedFromDescriptions(ideo);\n\n  const neighborhoodAnnots =\n    Object.entries(neighborhoods).map(([chr, neighborhood], index) => {\n      const start = parseInt(Object.keys(neighborhood)[0]);\n      let paralogs = Object.values(neighborhood)[0];\n\n      if (paralogs.length < 2) {\n        return {paralogs};\n      }\n\n      // paralogs.map(paralog => {\n      //   console.log(paralog);\n      // })\n\n      const description =\n        `${paralogs.length} nearby paralogs of ${searchedGene}`;\n\n      const chrLength = ideo.chromosomes[ideo.config.taxid][chr].bpLength;\n      let annotStart = start - overlayAnnotLength/2;\n      let annotStop = start + overlayAnnotLength/2;\n      if (annotStop > chrLength) {\n        annotStart = start - overlayAnnotLength;\n        annotStop = chrLength;\n      } else if (annotStart < 1) {\n        annotStart = 1;\n        annotStop = overlayAnnotLength;\n      };\n\n      if ('geneCache' in ideo) {\n        paralogs = paralogs.map(paralog => {\n          paralog.fullName = ideo.geneCache.fullNamesById[paralog.id];\n          return paralog;\n        });\n      }\n\n      const key = 'paralogNeighborhood-' + index;\n      const fStart = start.toLocaleString(); // Format for readability\n      const displayCoordinates = `chr${chr}:${fStart} ± ${windowProse}`;\n\n      const annot = {\n        name: key,\n        chr,\n        start: annotStart,\n        stop: annotStop,\n        color: 'pink',\n        description,\n        paralogs,\n        type: 'paralog neighborhood',\n        displayCoordinates\n      };\n\n      ideo.annotDescriptions.annots[annot.name] = annot;\n      return annot;\n    }).filter(n => n.paralogs.length > 1);\n\n  if (neighborhoodAnnots.length > 0) {\n    // console.log('neighborhoodAnnots')\n    // console.log(neighborhoodAnnots.map(na => na));\n    ideo.drawAnnots(neighborhoodAnnots, 'overlay', true, true);\n    moveLegend();\n  }\n}\n\n/**\n * Fetch paralogs of searched gene\n */\nasync function fetchParalogs(annot, ideo) {\n  const taxid = ideo.config.taxid;\n\n  let homologs;\n  // Fetch paralogs\n  if (ideo.paralogCache) {\n    // const baseUrl = 'http://localhost:8080/dist/data/cache/paralogs/';\n    // const url = `${baseUrl}homo-sapiens/${annot.name}.tsv`;\n    // const response = await fetch(url);\n    // const oneRowTsv = await response.text();\n    // const rawHomologEnsemblIds = oneRowTsv.split('\\t');\n    // homologs = rawHomologEnsemblIds.map(r => getEnsemblId('ENSG', r));\n    const paralogsByName = ideo.paralogCache.paralogsByName;\n    const nameUc = annot.name.toUpperCase();\n    const hasParalogs = nameUc in paralogsByName;\n    homologs = hasParalogs ? paralogsByName[nameUc] : [];\n  } else {\n    const params = `&format=condensed&type=paralogues&target_taxon=${taxid}`;\n    const path = `/homology/id/${annot.id}?${params}`;\n    const ensemblHomologs = await Ideogram.fetchEnsembl(path);\n    homologs = ensemblHomologs.data[0].homologies;\n  }\n\n\n  // Fetch positions of paralogs\n  let annots =\n    await fetchParalogPositionsFromMyGeneInfo(homologs, annot, ideo);\n\n  // Omit genes named like \"AC113554.1\", which is an \"accession.version\".\n  // Such accVers are raw and poorly suited here.\n  annots = annots.filter(annot => {\n    const isAccVer = annot.name.match(/^AC[0-9.]+$/);\n    return !isAccVer;\n  });\n\n  return annots;\n}\n\n/**\n * Filters out placements on alternative loci scaffolds, an advanced\n * genome assembly feature we are not concerned with in ideograms.\n *\n * Example:\n * https://mygene.info/v3/query?q=symbol:PTPRC&species=9606&fields=symbol,genomic_pos,name\n */\nfunction getGenomicPos(gene, ideo) {\n  let genomicPos = null;\n  if (Array.isArray(gene.genomic_pos)) {\n    genomicPos = gene.genomic_pos.filter(pos => {\n      return pos.chr in ideo.chromosomes[ideo.config.taxid];\n    })[0];\n  } else {\n    genomicPos = gene.genomic_pos;\n  }\n  return genomicPos;\n}\n\n/**\n * Transforms MyGene.info (MGI) gene into Ideogram annotation\n */\nfunction parseAnnotFromMgiGene(gene, ideo, color='red') {\n  const genomicPos = getGenomicPos(gene, ideo);\n\n  const annot = {\n    name: gene.symbol,\n    chr: genomicPos.chr,\n    start: genomicPos.start,\n    stop: genomicPos.end,\n    id: genomicPos.ensemblgene,\n    color\n  };\n\n  return annot;\n}\n\nfunction moveLegend() {\n  const ideoInnerDom = document.querySelector('#_ideogramInnerWrap');\n  const decorPad = setRelatedDecorPad({}).legendPad;\n  const left = decorPad + 20;\n  const legendStyle = `position: absolute; top: 15px; left: ${left}px`;\n  const legend = document.querySelector('#_ideogramLegend');\n  ideoInnerDom.prepend(legend);\n  legend.style = legendStyle;\n}\n\n/** Filter annotations to only include those in configured list */\nfunction applyAnnotsIncludeList(annots, ideo) {\n\n  if (ideo.config.annotsInList === 'all') return annots;\n\n  const includedAnnots = [];\n  annots.forEach(annot => {\n    if (ideo.config.annotsInList.includes(annot.name.toLowerCase())) {\n      includedAnnots.push(annot);\n    }\n  });\n  return includedAnnots;\n}\n\n/** Fetch and draw interacting genes, return Promise for annots */\nfunction processInteractions(annot, ideo) {\n  return new Promise(async (resolve) => {\n    const t0 = performance.now();\n\n    const interactions = await fetchInteractions(annot, ideo);\n    const annots = await fetchInteractionAnnots(interactions, annot, ideo);\n\n    ideo.relatedAnnots.push(...annots);\n    finishPlotRelatedGenes('interacting', ideo);\n\n    ideo.time.rg.interactions = timeDiff(t0);\n\n    resolve();\n  });\n}\n\n/** Find and draw paralogs, return Promise for annots */\nfunction processParalogs(annot, ideo) {\n  return new Promise(async (resolve) => {\n    const t0 = performance.now();\n\n    const annots = await fetchParalogs(annot, ideo);\n    ideo.relatedAnnots.push(...annots);\n    finishPlotRelatedGenes('paralogous', ideo);\n    overplotParalogs(annots, ideo);\n\n    ideo.time.rg.paralogs = timeDiff(t0);\n\n    resolve();\n  });\n}\n\n// /**\n//  * Sorts gene names consistently.\n//  *\n//  * Might also loosely rank by first-discovered or most prominent\n//  */\n// function sortGeneNames(aName, bName) {\n//   // Rank shorter names above longer names\n//   if (bName.length !== aName.length) return bName.length - aName.length;\n\n//   // Rank names of equal length alphabetically\n//   return [aName, bName].sort().indexOf(aName) === 0 ? 1 : -1;\n// }\n\n/** Sorts by relevance of related type, then rank */\nexport function sortByRelatedType(a, b) {\n  var aName, bName, aColor, bColor;\n  if ('name' in a) {\n    // Locally processed annotations\n    aName = a.name;\n    bName = b.name;\n    aColor = a.color;\n    bColor = b.color;\n  } else {\n    // Raw annotations\n    [aName, aColor] = [a[0], a[3]];\n    [bName, bColor] = [b[0], b[3]];\n  }\n\n  // Rank red (searched gene) highest\n  if (aColor === 'red') return -1;\n  if (bColor === 'red') return 1;\n\n  // Rank purple (interacting gene) above pink (paralogous gene)\n  if (aColor === 'purple' && bColor === 'pink') return -1;\n  if (bColor === 'purple' && aColor === 'pink') return 1;\n\n  return a.rank - b.rank;\n\n  // return sortGeneNames(aName, bName);\n}\n\nfunction mergeDescriptions(annot, desc, ideo) {\n  let mergedDesc;\n  const descriptions = ideo.annotDescriptions.annots;\n\n  if (annot.name in descriptions) {\n    const otherDesc = descriptions[annot.name];\n    mergedDesc = desc;\n    if (desc.type === otherDesc.type) return;\n    Object.keys(otherDesc).forEach(function(key) {\n      if (key in mergedDesc === false) {\n        mergedDesc[key] = otherDesc[key];\n      }\n    });\n    // Object.assign({}, descriptions[annot.name]);\n    if ('type' in otherDesc) {\n      mergedDesc.type += ', ' + otherDesc.type;\n      mergedDesc.description += `<br/><br/>${otherDesc.description}`;\n    }\n  } else {\n    mergedDesc = desc;\n  }\n\n  ideo.annotDescriptions.annots[annot.name] = mergedDesc;\n}\n\nfunction mergeAnnots(unmergedAnnots) {\n\n  const seenAnnots = {};\n  let mergedAnnots = [];\n\n  unmergedAnnots.forEach((annot) => {\n    if (annot.name in seenAnnots === false) {\n      mergedAnnots.push(annot);\n      seenAnnots[annot.name] = 1;\n    } else {\n      if (annot.color === 'purple') {\n        mergedAnnots = mergedAnnots.map((mergedAnnot) => {\n          return (annot.name === mergedAnnot.name) ? annot : mergedAnnot;\n        });\n      }\n    }\n  });\n\n  return mergedAnnots;\n}\n\n/** Filter, sort, draw annots.  Move legend. */\nfunction finishPlotRelatedGenes(type, ideo) {\n  setRelatedAnnotDomIds(ideo);\n\n  let annots = deepCopy(ideo.relatedAnnots);\n\n  annots = applyAnnotsIncludeList(annots, ideo);\n  annots = mergeAnnots(annots);\n\n  // annots = applyRankCutoff(annots, 40, ideo);\n  ideo.relatedAnnots = mergeAnnots(annots);\n  // ideo.relatedAnnots = applyRankCutoff(annots, 40, ideo);\n  // annots.sort(sortByRelatedType);\n  ideo.relatedAnnots.sort(ideo.annotSortFunction);\n\n  // ideo.relatedAnnots = ideo.relatedAnnots.slice(0, 40);\n\n  if (annots.length > 1 && ideo.onFindGenesCallback) {\n    ideo.onFindGenesCallback();\n  }\n\n  ideo.drawAnnots(annots);\n  // const idsToRemove = annots.slice(40).map(a => a.domId);\n  // if (idsToRemove.length > 0) {\n  //   const selector = '#' + idsToRemove.join(',#')\n  //   document.querySelectorAll(selector).forEach(el => el.remove());\n  // }\n\n  if (ideo.config.showAnnotLabels) {\n    ideo.fillAnnotLabels(ideo.relatedAnnots);\n  }\n\n  moveLegend();\n\n  analyzePlotTimes(type, ideo);\n}\n\n/** Fetch position of searched gene, return corresponding annotation */\nasync function processSearchedGene(geneSymbol, ideo) {\n  const t0 = performance.now();\n\n  const data = await fetchGenes(geneSymbol, 'symbol', ideo);\n\n  if (data.hits.length === 0) {\n    return;\n  }\n  const gene = data.hits.find(hit => {\n    const genomicPos = getGenomicPos(hit, ideo); // omits alt loci\n    return genomicPos && genomicPos.ensemblgene;\n  });\n  const ensemblId = gene.genomic_pos.ensemblgene;\n\n  // Assign tooltip content.  Much of the content is often retrieved from\n  // the gene cache.  In that case, all fields except `name` are fetched\n  // from cache.  Occasionally, e.g. often upon the very first search, no\n  // content is yet available from cache.\n  let desc = {description: '', ensemblId, type: 'searched gene'};\n  if (gene.symbol in ideo.annotDescriptions.annots) {\n    // Most content already set via cache.\n    // `name` will be set via non-blocking part of `fetchGenes`.\n    const oldDesc = ideo.annotDescriptions.annots[gene.symbol];\n    desc = Object.assign(oldDesc, desc);\n  } else {\n    // No content has been set yet via cache.  In this case, `gene` already\n    // has all the data needed for the searched gene's tooltip content.\n    desc.name = gene.name;\n  }\n\n  ideo.annotDescriptions.annots[gene.symbol] = desc;\n\n  const annot = parseAnnotFromMgiGene(gene, ideo);\n\n  ideo.relatedAnnots.push(annot);\n\n  ideo.time.rg.searchedGene = timeDiff(t0);\n\n  return annot;\n}\n\nfunction adjustPlaceAndVisibility(ideo) {\n  var ideoContainerDom = document.querySelector(ideo.config.container);\n\n  ideoContainerDom.style.visibility = '';\n  ideoContainerDom.style.position = 'absolute';\n  ideoContainerDom.style.width = '100%';\n\n  var ideoInnerDom = document.querySelector('#_ideogramInnerWrap');\n  ideoInnerDom.style.position = 'relative';\n  ideoInnerDom.style.marginLeft = 'auto';\n  ideoInnerDom.style.marginRight = 'auto';\n  ideoInnerDom.style.overflowY = 'hidden';\n  document.querySelector('#_ideogramMiddleWrap').style.overflowY = 'hidden';\n\n  const legendPad = ideo.config.legendPad;\n\n  if (typeof ideo.didAdjustIdeogramLegend === 'undefined') {\n    // Accounts for moving legend when external content at left or right\n    // is variable upon first rendering plotted genes\n\n    var ideoDom = document.querySelector('#_ideogram');\n    const legendWidth = 160;\n    ideoInnerDom.style.maxWidth =\n      (\n        parseInt(ideoInnerDom.style.maxWidth) +\n        legendWidth +\n        legendPad\n      ) + 'px';\n\n    ideoDom.style.minWidth =\n      (parseInt(ideoDom.style.minWidth) + legendPad) + 'px';\n    ideoDom.style.maxWidth =\n      (parseInt(ideoDom.style.minWidth) + legendPad) + 'px';\n    ideoDom.style.position = 'relative';\n    ideoDom.style.left = legendWidth + 'px';\n\n    ideo.didAdjustIdeogramLegend = true;\n  }\n}\n\n// function sortByPathwayIxn(a, b) {\n//   const aColor = a.color;\n//   const bColor = b.color;\n\n//   // Rank red (searched gene) highest\n//   if (aColor === 'red') return -1;\n//   if (bColor === 'red') return 1;\n\n//   // Rank not grey above grey\n//   if (aColor === 'grey' && bColor !== 'grey') return 1;\n//   if (bColor === 'grey' && aColor !== 'grey') return -1;\n\n//   return a.rank - b.rank;\n// }\n\n// async function fetchPathwayGeneAnnots(searchedGene, pathway, ideo) {\n//   const annots = [];\n\n//   const pathwayIxns =\n//     await fetchPathwayInteractions(searchedGene.name, pathway.id, ideo);\n\n//   const pathwayGenes = Object.keys(pathwayIxns);\n//   const data = await fetchGenes(pathwayGenes, 'symbol', ideo);\n\n//   const ixnColors = {\n//     'Stimulates': 'green',\n//     'Stimulated by': 'green',\n//     'Necessarily stimulates': 'green',\n//     'Necessarily stimulated by': 'green',\n//     'Transcribes / translates': 'brown',\n//     'Transcribed / translated by': 'brown',\n//     'Inhibits': 'red',\n//     'Inhibited by': 'red',\n//     'Modifies': 'blue',\n//     'Modified by': 'blue',\n//     'Acts on': 'blue',\n//     'Acted on by': 'blue',\n//     'Catalyzes': 'orange',\n//     'Catalyzed by': 'orange',\n//     'Converts': 'orange',\n//     'Converted by': 'orange',\n//     'Binds': 'black',\n//     'Shares pathway with': 'grey'\n//   };\n\n//   data.hits.forEach(gene => {\n//     // If hit lacks position\n//     // or is same as searched gene (e.g. search for human SRC),\n//     // then skip processing\n//     if (\n//       'genomic_pos' in gene === false ||\n//       gene.symbol === searchedGene.name\n//     ) {\n//       return;\n//     }\n\n//     // Account for edge case: cyclic AMP (cAMP) is not \"CAMP\" gene\n//     if (gene.symbol === 'cAMP') return;\n\n//     const summary = pathwayIxns[gene.symbol];\n//     const color = ixnColors[summary];\n//     // if (color !== 'blue') console.log(gene);\n\n//     const annot = parseAnnotFromMgiGene(gene, ideo, color);\n//     annots.push(annot);\n\n//     const descriptionObj =\n//       describePathwayGene(gene, searchedGene, pathway, summary);\n\n//     mergeDescriptions(annot, descriptionObj, ideo);\n//   });\n\n//   ideo.annotSortFunction = sortByPathwayIxn;\n\n//   const sortedAnnots = annots.sort(sortByPathwayIxn).slice(0, 40);\n\n//   return sortedAnnots;\n// }\n\n// /**\n//  *\n//  */\n// async function plotPathwayGenes(searchedGene, pathway, ideo) {\n//   const headerTitle = 'Genes in pathway';\n//   initAnnotDescriptions(ideo, headerTitle);\n\n//   legendPathwayName = pathway.name;\n//   ideo.config.legend = pathwayLegend;\n//   writeLegend(ideo);\n//   moveLegend();\n\n//   ideo.relatedAnnots = [];\n\n//   await processSearchedGene(searchedGene.name, ideo);\n\n//   const annots = await fetchPathwayGeneAnnots(searchedGene, pathway, ideo);\n//   ideo.relatedAnnots.push(...annots);\n//   finishPlotRelatedGenes('pathway', ideo);\n// }\n\nfunction initAnnotDescriptions(ideo, headerTitle) {\n  const organism = ideo.getScientificName(ideo.config.taxid);\n  const version = Ideogram.version;\n  const headers = [\n    `# ${headerTitle}`,\n    `# Organism: ${organism}`,\n    `# Generated by Ideogram.js version ${version}, https://github.com/eweitz/ideogram`,\n    `# Generated at ${window.location.href}`\n  ].join('\\n');\n\n  delete ideo.annotDescriptions;\n  ideo.annotDescriptions = {headers, annots: {}};\n\n}\n\n/**\n * For given gene, finds and draws interacting genes and paralogs\n *\n * @param geneSymbol {String} Gene symbol, e.g. RAD51\n */\nasync function plotRelatedGenes(geneSymbol=null) {\n\n  const ideo = this;\n\n  if (!geneSymbol) {\n    return plotGeneHints(ideo);\n  }\n\n  ideo.clearAnnotLabels();\n  const legend = document.querySelector('#_ideogramLegend');\n  if (legend) legend.remove();\n\n  ideo.config = setRelatedDecorPad(ideo.config);\n\n  initAnnotDescriptions(ideo, `Related genes for ${geneSymbol}`);\n\n  const ideoSel = ideo.selector;\n  const annotSel = ideoSel + ' .annot';\n  document.querySelectorAll(annotSel).forEach(el => el.remove());\n\n  ideo.startHideAnnotTooltipTimeout();\n\n  // Refine style\n  document.querySelectorAll('.chromosome').forEach(chromosome => {\n    chromosome.style.cursor = '';\n  });\n\n  adjustPlaceAndVisibility(ideo);\n\n  ideo.relatedAnnots = [];\n\n  // Fetch positon of searched gene\n  const annot = await processSearchedGene(geneSymbol, ideo);\n\n  if (typeof annot === 'undefined') throwGeneNotFound(geneSymbol, ideo);\n\n  ideo.config.legend = relatedLegend;\n  writeLegend(ideo);\n  moveLegend();\n\n  await Promise.all([\n    processInteractions(annot, ideo),\n    processParalogs(annot, ideo)\n  ]);\n\n  ideo.time.rg.total = timeDiff(ideo.time.rg.t0);\n\n  analyzeRelatedGenes(ideo);\n\n  if (ideo.onPlotFoundGenesCallback) ideo.onPlotFoundGenesCallback();\n}\n\nfunction getAnnotByName(annotName, ideo) {\n  var annotByName;\n  ideo.annots.forEach(annotsByChr => {\n    annotsByChr.annots.forEach(annot => {\n      if (annotName === annot.name) {\n        annotByName = annot;\n      }\n    });\n  });\n\n  if (annotByName === null) {\n    annotByName = ideo.annotDescriptions.annots[annotName];\n  }\n  return annotByName;\n}\n\n/**\n * Manage click on pathway links in annotation tooltips\n */\n// function managePathwayClickHandlers(searchedGene, ideo) {\n//   setTimeout(function() {\n//     const pathways = document.querySelectorAll('.ideo-pathway-link');\n//     if (pathways.length > 0 && !ideo.addedPathwayClickHandler) {\n//       pathways.forEach(pathway => {\n//         // pathway.removeEventListener('click', handlePathwayClick);\n//         pathway.addEventListener('click', function(event) {\n//           const target = event.target;\n//           const pathwayId = target.getAttribute('data-pathway-id');\n//           const pathwayName = target.getAttribute('data-pathway-name');\n//           const pathway = {id: pathwayId, name: pathwayName};\n//           plotPathwayGenes(searchedGene, pathway, ideo);\n//         });\n//       });\n\n//       // Ensures handler isn't added redundantly.  This is used because\n//       // addEventListener options like {once: true} don't suffice\n//       // ideo.addedPathwayClickHandler = true;\n//     }\n//   }, 100);\n// }\n\nfunction onDidShowAnnotTooltip() {\n  const ideo = this;\n  handleTooltipClick(ideo);\n  addGeneStructureListeners(ideo);\n}\n\n/**\n * Handles click within annotation tooltip\n *\n * Makes clicking link in tooltip behave same as clicking annotation\n */\nexport function handleTooltipClick(ideo) {\n  // const tooltip = document.querySelector('._ideogramTooltip');\n  // if (!ideo.addedTooltipClickHandler) {\n  //   tooltip.addEventListener('click', () => {\n  //     const geneDom = document.querySelector('#ideo-related-gene');\n  //     const annotName = geneDom.textContent;\n  //     const annot = getAnnotByName(annotName, ideo);\n  //     ideo.onClickAnnot(annot);\n  //   });\n\n  //   // Ensures handler isn't added redundantly.  This is used because\n  //   // addEventListener options like {once: true} don't suffice\n  //   ideo.addedTooltipClickHandler = true;\n  // }\n\n  const tooltip = document.querySelector('._ideogramTooltip');\n  if (!ideo.addedTooltipClickHandler) {\n    tooltip.addEventListener('click', (event) => {\n      if (['input', 'label'].includes(event.target.localName)) {\n        return;\n      }\n\n      let geneDom = document.querySelector('#ideo-related-gene');\n      if (!geneDom) {\n        geneDom = event.target;\n      }\n      const annotName = geneDom.textContent;\n      const annot = getAnnotByName(annotName, ideo);\n\n      ideo.onClickAnnot(annot);\n    });\n\n    // Ensures handler isn't added redundantly.  This is used because\n    // addEventListener options like {once: true} don't suffice\n    ideo.addedTooltipClickHandler = true;\n  }\n}\n\n/** Return searched gene from annotation descriptions in Ideogram object */\nfunction getSearchedFromDescriptions(ideo) {\n  return (\n    Object.entries(ideo.annotDescriptions.annots)\n      .find(([k, v]) => v.type === 'searched gene')[0]\n  );\n}\n\nfunction decorateInteractingGene(annot, descObj, ideo) {\n  if ('type' in descObj && descObj.type.includes('interacting gene')) {\n    const pathwayIds = descObj.pathwayIds;\n    // Get symbol of the searched gene, e.g. \"PTEN\"\n    const searchedGene = getSearchedFromDescriptions(ideo);\n\n    const gpmls = ideo.gpmlsByInteractingGene[annot.name];\n\n    const summary =\n      summarizeInteractions(annot.name, searchedGene, pathwayIds, gpmls);\n    if (summary !== null) {\n      const oldSummary = 'Interacts with';\n      descObj.description =\n        descObj.description.replace(oldSummary, summary);\n    }\n  }\n\n  return descObj;\n}\n\nfunction decorateParalogNeighborhood(annot, descObj, style) {\n  // Rank 1st highest, then put it last as it already has a triangle\n  // annotation, and is often also labeled.\n  const sortedParalogs =\n    descObj.paralogs.sort((a, b) => a.rank - b.rank);\n  const firstRanked = sortedParalogs.shift(); // Take off first\n  sortedParalogs.push(firstRanked); // Make it last\n\n  const originalDisplay =\n    'Paralog neighborhood<br/>' +\n    '<br/>' +\n    descObj.description + ':<br/>' +\n    `${sortedParalogs\n      .map(paralog => {\n        let title = '';\n        if (paralog.fullName) title = paralog.fullName;\n        if (paralog.rank) {\n          const rank = paralog.rank;\n          title += ` &#013;Ranked ${rank} in general or scholarly interest`;\n        }\n        if (title !== '') title = `title=\"${title}\"`;\n        return (\n          `<span class=\"ideo-paralog-neighbor\" ${title} ${style}'>${\n            paralog.name\n          }</span>`\n        );\n      }).join('<br/>')}` +\n    '<br/>';\n  annot.displayCoordinates = descObj.displayCoordinates;\n\n  return [annot, originalDisplay];\n}\n\n/**\n * Enhance tooltip shown on hovering over gene annotation\n */\nfunction decorateAnnot(annot) {\n  const ideo = this;\n  if (\n    annot.name === ideo.prevClickedAnnot?.name &&\n    ideo.isTooltipCooling\n  ) {\n    // Cancels showing tooltip immediately after clicking gene\n    return null;\n  }\n\n  let descObj = ideo.annotDescriptions.annots[annot.name];\n\n  if (ideo.config.relatedGenesMode === 'related') {\n    descObj = decorateInteractingGene(annot, descObj, ideo);\n  }\n\n  const description =\n    descObj.description.length > 0 ? `<br/>${descObj.description}` : '';\n  const fullName = descObj.name;\n  const style = 'style=\"color: #0366d6; cursor: pointer;\"';\n\n  let fullNameAndRank = fullName;\n  if ('rank' in annot) {\n    const rank = 'Ranked ' + annot.rank + ' in general or scholarly interest';\n    fullNameAndRank = `<span title=\"${rank}\">${fullName}</span>`;\n  }\n\n  const isParalogNeighborhood = annot.name.includes('paralogNeighborhood');\n\n  const geneStructureHtml = getGeneStructureHtml(\n    annot, ideo, isParalogNeighborhood\n  );\n\n  let originalDisplay =\n    `<span id=\"ideo-related-gene\" ${style}>${annot.name}</span><br/>` +\n    `${fullNameAndRank}<br/>` +\n    description +\n    geneStructureHtml +\n    `<br/>`;\n\n  if (isParalogNeighborhood) {\n    [annot, originalDisplay] =\n      decorateParalogNeighborhood(annot, descObj, style);\n  }\n\n  annot.displayName = originalDisplay;\n\n  // managePathwayClickHandlers(annot, ideo);\n\n  return annot;\n}\n\nconst shape = 'triangle';\n\nfunction getLegendName(nameText) {\n  const legendHeaderStyle =\n    `font-size: 14px; font-weight: bold; font-color: #333;`;\n\n  return `\n    <div style=\"position: relative; left: 30px;\">\n      <div style=\"${legendHeaderStyle}\">${nameText}</div>\n      <i>Click gene to search</i>\n    </div>\n  `;\n}\n\nconst relatedLegend = [{\n  name: getLegendName('Related genes'),\n  nameHeight: 50,\n  rows: [\n    {name: 'Interacting gene', color: 'purple', shape: shape},\n    {name: 'Paralogous gene', color: 'pink', shape: shape},\n    {name: 'Searched gene', color: 'red', shape: shape}\n  ]\n}];\n\nlet legendPathwayName = '';\n\nconst pathwayLegend = [{\n  name: getLegendName('Related genes'),\n  nameHeight: 50,\n  rows: [\n    {name: 'Pathway gene', color: 'blue', shape: shape},\n    {name: 'Searched gene', color: 'red', shape: shape}\n  ]\n}];\n\nconst citedLegend = [{\n  name: getLegendName('Highly cited genes'),\n  nameHeight: 30,\n  rows: []\n}];\n\n/** Sets legendPad for related genes view */\nfunction setRelatedDecorPad(kitConfig) {\n  kitConfig.legendPad = kitConfig.showAnnotLabels ? 70 : 30;\n  return kitConfig;\n}\n\nconst globalKitDefaults = {\n  chrWidth: 9,\n  chrHeight: 100,\n  chrLabelSize: 12,\n  annotationHeight: 7,\n  showFullyBanded: false,\n  rotatable: false,\n  legend: relatedLegend,\n  chrBorderColor: '#333',\n  chrLabelColor: '#333',\n  onWillShowAnnotTooltip: decorateAnnot,\n  onDidShowAnnotTooltip,\n  showTools: true,\n  showAnnotLabels: true,\n  chrFillColor: {centromere: '#DAAAAA'}\n};\n\nfunction plotGeneHints() {\n  const ideo = this;\n\n  if (!ideo || 'annotDescriptions' in ideo) return;\n\n  ideo.annotDescriptions = {annots: {}};\n\n  ideo.flattenAnnots().map((annot) => {\n    let description = [];\n    if ('significance' in annot && annot.significance !== 'n/a') {\n      description.push(annot.significance);\n    }\n    if ('citations' in annot && annot.citations !== undefined) {\n      description.push(annot.citations);\n    }\n    description = description.join('<br/><br/>');\n    ideo.annotDescriptions.annots[annot.name] = {\n      description,\n      name: annot.fullName\n    };\n  });\n\n  adjustPlaceAndVisibility(ideo);\n  moveLegend();\n  ideo.fillAnnotLabels([]);\n  const container = ideo.config.container;\n  document.querySelector(container).style.visibility = '';\n}\n\n/**\n * Wrapper for Ideogram constructor, with generic \"Related genes\" options\n *\n * This function is made available as a static method on Ideogram.\n *\n * @param {Object} config Ideogram configuration object\n */\nfunction _initRelatedGenes(config, annotsInList) {\n\n  const isHuman = slug(config.organism) === 'homo-sapiens';\n\n  if (config.relatedGenesMode === 'leads') {\n    delete config.onDrawAnnots;\n    delete config.relatedGenesMode;\n  };\n\n  const kitDefaults = Object.assign({\n    showParalogNeighborhoods: isHuman,\n    relatedGenesMode: 'related',\n    useCache: true,\n    awaitCache: true\n  }, globalKitDefaults);\n\n  return initSearchIdeogram(kitDefaults, config, annotsInList);\n}\n\n/**\n * Wrapper for Ideogram constructor, with generic \"Gene leads\" options\n *\n * This function is made available as a static method on Ideogram.\n *\n * @param {Object} config Ideogram configuration object\n */\n function _initGeneLeads(config, annotsInList) {\n  delete config.onPlotFoundGenes;\n\n  if (config.legendName) {\n    citedLegend[0].name = getLegendName(config.legendName);\n  }\n\n  config.legend = citedLegend;\n\n  let rawPath, mode;\n  if (config.geneLeadsDE) {\n    mode = 'leads';\n    rawPath = 'annotations/gene_leads.tsv';\n  } else {\n    mode = 'hints';\n    rawPath = 'cache/homo-sapiens-top-genes.tsv';\n  }\n\n  const kitDefaults = Object.assign({\n    relatedGenesMode: mode,\n    chrMargin: -4,\n    // annotationsPath: getDir('cache/homo-sapiens-top-genes.tsv'),\n    annotationsPath: getDir(rawPath),\n    onDrawAnnots: plotGeneHints,\n    useCache: true\n  }, globalKitDefaults);\n\n  return initSearchIdeogram(kitDefaults, config, annotsInList);\n}\n\nfunction initSearchIdeogram(kitDefaults, config, annotsInList) {\n  if (annotsInList !== 'all') {\n    annotsInList = annotsInList.map(name => name.toLowerCase());\n  }\n  kitDefaults.annotsInList = annotsInList;\n\n  kitDefaults.legendPad = kitDefaults.showAnnotLabels ? 80 : 30;\n\n  if ('onWillShowAnnotTooltip' in config) {\n    const key = 'onWillShowAnnotTooltip';\n    const clientFn = config[key];\n    const defaultFunction = kitDefaults[key];\n    const newFunction = function(annot) {\n      annot = defaultFunction.bind(this)(annot);\n      annot = clientFn.bind(this)(annot);\n      return annot;\n    };\n    kitDefaults[key] = newFunction;\n    delete config[key];\n  }\n\n  if ('onDidShowAnnotTooltip' in config) {\n    const key = 'onDidShowAnnotTooltip';\n    const clientFn = config[key];\n    const defaultFunction = kitDefaults[key];\n    const newFunction = function(annot) {\n      annot = defaultFunction.bind(this)(annot);\n      annot = clientFn.bind(this)(annot);\n      return annot;\n    };\n    kitDefaults[key] = newFunction;\n    delete config[key];\n  }\n\n  if ('onDrawAnnots' in config) {\n    const key = 'onDrawAnnots';\n    const clientFn = config[key];\n    const defaultFn = kitDefaults[key];\n    const newFunction = function() {\n      if (defaultFn) defaultFn.bind(this)();\n      clientFn.bind(this)();\n    };\n    kitDefaults[key] = newFunction;\n    delete config[key];\n  }\n\n  // Override kit defaults if client specifies otherwise\n  const kitConfig = Object.assign(kitDefaults, config);\n\n  const ideogram = new Ideogram(kitConfig);\n\n  // Called upon 1) finding paralogs, and 2) finding interacting genes\n  if (config.onFindGenes) {\n    ideogram.onFindGenesCallback = config.onFindGenes;\n  }\n\n  // Called upon completing last plot, including all related genes\n  if (config.onPlotFoundGenes) {\n    ideogram.onPlotFoundGenesCallback = config.onPlotFoundGenes;\n  }\n\n  ideogram.getTooltipAnalytics = getRelatedGenesTooltipAnalytics;\n\n  ideogram.annotSortFunction = sortByRelatedType;\n\n  initAnalyzeRelatedGenes(ideogram);\n\n  return ideogram;\n}\n\nexport {\n  _initGeneLeads, _initRelatedGenes,\n  plotRelatedGenes, getRelatedGenesByType\n};\n","/**\n * @fileoverview Core module of Ideogram.js, links all other modules\n * This file defines the Ideogram class, its constructor method, and its\n * static methods.  All instance methods are defined in other modules.\n *\n */\n\nimport version from './version';\n\nimport {\n  configure, initDrawChromosomes, handleRotateOnClick, onLoad,\n  init, finishInit, writeContainer\n} from './init/init';\n\nimport {\n  onLoadAnnots, onDrawAnnots, processAnnotData, restoreDefaultTracks,\n  updateDisplayedTracks, initAnnotSettings, fetchAnnots, drawAnnots,\n  getHistogramBars, drawHeatmaps, deserializeAnnotsForHeatmap, fillAnnots,\n  drawProcessedAnnots, drawSynteny, startHideAnnotTooltipTimeout,\n  showAnnotTooltip, onWillShowAnnotTooltip, onDidShowAnnotTooltip,\n  setOriginalTrackIndexes,\n  afterRawAnnots, onClickAnnot, downloadAnnotations, addAnnotLabel,\n  removeAnnotLabel, fillAnnotLabels, clearAnnotLabels, flattenAnnots\n  // fadeOutAnnotLabels\n} from './annotations/annotations';\n\nimport {highlight, unhighlight} from './annotations/highlight';\n\nimport {\n  esearch, esummary, elink,\n  getOrganismFromEutils, getTaxids,\n  getAssemblyAndChromosomesFromEutils\n} from './services/services';\n\nimport {\n  drawBandLabels, getBandColorGradients, processBandData,\n  setBandsToShow, hideUnshownBandLabels, drawBandLabelText, drawBandLabelStalk\n} from './bands/bands';\n\nimport {onBrushMove, onBrushEnd, createBrush} from './brush';\nimport {onCursorMove, createClickCursor} from './cursor';\nimport {drawSexChromosomes, setSexChromosomes} from './sex-chromosomes';\nimport {convertBpToPx, convertPxToBp} from './coordinate-converters';\nimport {\n  unpackAnnots, packAnnots, initCrossFilter, filterAnnots\n} from './filter';\n\nimport {\n  assemblyIsAccession, getDataDir, round, onDidRotate, getSvg, d3,\n  getTaxid, getCommonName, getScientificName, fetch as _fetch,\n  isRoman, parseRoman\n} from './lib';\n\nimport {\n  getChromosomeModel, getChromosomePixels\n} from './views/chromosome-model';\n\nimport {\n  appendHomolog, drawChromosome, rotateAndToggleDisplay, setOverflowScroll\n} from './views/draw-chromosomes';\n\nimport {\n  drawChromosomeLabels, rotateChromosomeLabels\n} from './views/chromosome-labels.js';\n\nimport {\n  _initGeneLeads, _initRelatedGenes,\n  plotRelatedGenes, getRelatedGenesByType\n} from './kit/related-genes';\n\nexport default class Ideogram {\n  constructor(config) {\n\n    // Functions from init.js\n    this.configure = configure;\n    this.initDrawChromosomes = initDrawChromosomes;\n    this.onLoad = onLoad;\n    this.handleRotateOnClick = handleRotateOnClick;\n    this.init = init;\n    this.finishInit = finishInit;\n    this.writeContainer = writeContainer;\n\n    // Functions from annotations.js\n    this.onLoadAnnots = onLoadAnnots;\n    this.onDrawAnnots = onDrawAnnots;\n    this.processAnnotData = processAnnotData;\n    this.restoreDefaultTracks = restoreDefaultTracks;\n    this.updateDisplayedTracks = updateDisplayedTracks;\n    this.initAnnotSettings = initAnnotSettings;\n    this.fetchAnnots = fetchAnnots;\n    this.drawAnnots = drawAnnots;\n    this.getHistogramBars = getHistogramBars;\n    this.drawHeatmaps = drawHeatmaps;\n    this.deserializeAnnotsForHeatmap = deserializeAnnotsForHeatmap;\n    this.fillAnnots = fillAnnots;\n    this.drawProcessedAnnots = drawProcessedAnnots;\n    this.drawSynteny = drawSynteny;\n    this.startHideAnnotTooltipTimeout = startHideAnnotTooltipTimeout;\n    this.showAnnotTooltip = showAnnotTooltip;\n    this.onWillShowAnnotTooltip = onWillShowAnnotTooltip;\n    this.onDidShowAnnotTooltip = onDidShowAnnotTooltip;\n    this.onClickAnnot = onClickAnnot;\n    this.setOriginalTrackIndexes = setOriginalTrackIndexes;\n    this.afterRawAnnots = afterRawAnnots;\n    this.downloadAnnotations = downloadAnnotations;\n    this.addAnnotLabel = addAnnotLabel;\n    this.removeAnnotLabel = removeAnnotLabel;\n    // this.fadeOutAnnotLabels = fadeOutAnnotLabels;\n    this.fillAnnotLabels = fillAnnotLabels;\n    this.clearAnnotLabels = clearAnnotLabels;\n    this.flattenAnnots = flattenAnnots;\n\n    this.highlight = highlight;\n    this.unhighlight = unhighlight;\n\n    // Variables and functions from services.js\n    this.esearch = esearch;\n    this.esummary = esummary;\n    this.elink = elink;\n    this.getOrganismFromEutils = getOrganismFromEutils;\n    this.getTaxids = getTaxids;\n    this.getAssemblyAndChromosomesFromEutils =\n      getAssemblyAndChromosomesFromEutils;\n\n    // Functions from bands.js\n    this.drawBandLabels = drawBandLabels;\n    this.getBandColorGradients = getBandColorGradients;\n    this.processBandData = processBandData;\n    this.setBandsToShow = setBandsToShow;\n    this.hideUnshownBandLabels = hideUnshownBandLabels;\n    this.drawBandLabelText = drawBandLabelText;\n    this.drawBandLabelStalk = drawBandLabelStalk;\n\n    // Functions from brush.js\n    this.onBrushMove = onBrushMove;\n    this.onBrushEnd = onBrushEnd;\n    this.createBrush = createBrush;\n\n    // Functions from cursor.js\n    this.createClickCursor = createClickCursor;\n    this.onCursorMove = onCursorMove;\n\n    // Functions from sex-chromosomes.js\n    this.drawSexChromosomes = drawSexChromosomes;\n    this.setSexChromosomes = setSexChromosomes;\n\n    // Functions from coordinate-converters.js\n    this.convertBpToPx = convertBpToPx;\n    this.convertPxToBp = convertPxToBp;\n\n    // Functions from filter.js\n    this.unpackAnnots = unpackAnnots;\n    this.packAnnots = packAnnots;\n    this.initCrossFilter = initCrossFilter;\n    this.filterAnnots = filterAnnots;\n\n    // Functions from lib\n    this.assemblyIsAccession = assemblyIsAccession;\n    this.getDataDir = getDataDir;\n    this.round = round;\n    this.onDidRotate = onDidRotate;\n    this.getSvg = getSvg;\n    this.fetch = _fetch;\n    this.getTaxid = getTaxid;\n    this.getCommonName = getCommonName;\n    this.getScientificName = getScientificName;\n\n    // Functions from views/chromosome-model.js\n    this.getChromosomeModel = getChromosomeModel;\n    this.getChromosomePixels = getChromosomePixels;\n\n    // Functions from views/chromosome-labels.js\n    this.drawChromosomeLabels = drawChromosomeLabels;\n    this.rotateChromosomeLabels = rotateChromosomeLabels;\n\n    // Functions from views/draw-chromosomes.js\n    this.appendHomolog = appendHomolog;\n    this.drawChromosome = drawChromosome;\n    this.rotateAndToggleDisplay = rotateAndToggleDisplay;\n    this.setOverflowScroll = setOverflowScroll;\n\n    this.plotRelatedGenes = plotRelatedGenes;\n    this.getRelatedGenesByType = getRelatedGenesByType;\n\n    this.configure(config);\n  }\n\n  /**\n   * Get the current version of Ideogram.js\n   */\n  static get version() {\n    return version;\n  }\n\n  /**\n  * Enable use of D3 in client apps, via \"d3 = Ideogram.d3\"\n  */\n  static get d3() {\n    return d3;\n  }\n\n  /**\n   * Request data from Ensembl REST API\n   * Docs: https://rest.ensembl.org/\n   *\n   * @param {String} path URL path\n   * @param {Object} body POST body\n   * @param {String} method HTTP method; 'GET' (default) or 'POST'\n   */\n  static async fetchEnsembl(path, body = null, method = 'GET') {\n    const init = {\n      method: method\n    };\n    if (body !== null) init.body = JSON.stringify(body);\n    if (method === 'GET') {\n      // Use HTTP parameter, not header, to avoid needless OPTIONS request\n      const delimiter = path.includes('&') ? '&' : '?';\n      path += delimiter + 'content-type=application/json';\n    } else {\n      // Method is POST, so content-type must be defined in header\n      init.headers = {'Content-Type': 'application/json'};\n    }\n\n    // const random = Math.random();\n    // console.log(random)\n    // if (random < 0.5) {\n    const response = await fetch(`https://rest.ensembl.org${path}`, init);\n    const json = await response.json();\n    return json;\n    // } else {\n    //   // Mock error\n    //   init.headers = {'Content-Type': 'application/json'};\n    //   const response = await fetch('https://httpstat.us/500/cors', init);\n    //   const json = await response.json();\n    //   return json;\n    // }\n  }\n\n  /**\n   * Helper for sortChromosomes().\n   * Gets names and biological types for diverse chromosome variables\n   */\n  static getChrSortNamesAndTypes(a, b) {\n    var chrAName, chrBName,\n      aIsCP, bIsCP, aIsMT, bIsMT, aIsAP, bIsAP, aIsNuclear, bIsNuclear;\n\n    if (typeof a === 'string' || 'chr' in a && 'annots' in a) {\n      // Chromosome data is from either:\n      //    - Ideogram static file cache (e.g. homo-sapiens.json)\n      //    - Ideogram raw annotations\n      chrAName = (typeof a === 'string') ? a : a.chr;\n      chrBName = (typeof b === 'string') ? b : b.chr;\n\n      aIsCP = chrAName === 'CP';\n      bIsCP = chrBName === 'CP';\n      aIsMT = chrAName === 'MT';\n      bIsMT = chrBName === 'MT';\n      aIsAP = chrAName === 'AP';\n      bIsAP = chrBName === 'AP';\n      aIsNuclear = (!aIsCP && !aIsMT && !aIsAP);\n      bIsNuclear = (!bIsCP && !bIsMT && !bIsAP);\n    } else {\n      // Chromosome data is from NCBI E-Utils web API\n      chrAName = a.name;\n      chrBName = b.name;\n\n      aIsCP = a.type === 'chloroplast';\n      bIsCP = b.type === 'chloroplast';\n      aIsMT = a.type === 'mitochondrion';\n      bIsMT = b.type === 'mitochondrion';\n      aIsAP = a.type === 'apicoplast';\n      bIsAP = b.type === 'apicoplast';\n      aIsNuclear = a.type === 'nuclear';\n      bIsNuclear = b.type === 'nuclear';\n    }\n\n    const chrTypes = {\n      aIsNuclear, bIsNuclear, aIsCP, bIsCP, aIsMT, bIsMT, aIsAP, bIsAP\n    };\n\n    return [chrAName, chrBName, chrTypes];\n  }\n\n  /**\n   * Sorts two chromosome objects by type and name\n   * - Nuclear chromosomes come before non-nuclear chromosomes.\n   * - Among nuclear chromosomes, use \"natural sorting\", e.g.\n   *   numbers come before letters\n   * - Among non-nuclear chromosomes, i.e. \"MT\" (mitochondrial DNA) and\n   *   \"CP\" (chromoplast DNA), MT comes first\n   *\n   * @param a Chromosome string or object \"A\"\n   * @param b Chromosome string or object \"B\"\n   * @returns {Number} JavaScript sort order indicator\n   */\n  static sortChromosomes(a, b) {\n\n    let [chrAName, chrBName, chrTypes] =\n      Ideogram.getChrSortNamesAndTypes(a, b);\n\n    const {\n      aIsNuclear, bIsNuclear, aIsCP, bIsCP, aIsMT, bIsMT, aIsAP, bIsAP\n    } = chrTypes;\n\n    if (aIsNuclear && bIsNuclear) {\n\n      if (isRoman(chrAName) && isRoman(chrBName)) {\n        // As in yeast genome\n        chrAName = parseRoman(chrAName).toString();\n        chrBName = parseRoman(chrBName).toString();\n      }\n\n      return chrAName.localeCompare(chrBName, 'en', {numeric: true});\n    } else if (!aIsNuclear && bIsNuclear) {\n      return 1;\n    } else if (aIsMT && bIsCP) {\n      return 1;\n    } else if (aIsCP && bIsMT) {\n      return -1;\n    } else if (!aIsAP && !aIsMT && !aIsCP && (bIsMT || bIsCP || bIsAP)) {\n      return -1;\n    }\n  }\n\n  /**\n   * Wrapper for Ideogram constructor, with generic \"Related genes\" options\n   *\n   * @param {Object} config Ideogram configuration object\n   */\n  static initRelatedGenes(config, annotsInList='all') {\n    return _initRelatedGenes(config, annotsInList);\n  }\n\n\n  /**\n   * Wrapper for Ideogram constructor, with generic \"Gene leads\" options\n   *\n   * @param {Object} config Ideogram configuration object\n  */\n  static initGeneLeads(config, annotsInList='all') {\n    return _initGeneLeads(config, annotsInList);\n  }\n}\n","var version = '1.41.0';\nexport default version;\n","import Ideogram from './ideogram';\n\n// Enable references to Ideogram when loaded via traditional script tag\nwindow.Ideogram = Ideogram;\n\n// Enable references to Ideogram when imported as an ES6 module\nexport default 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semblIds","homolog","fetchParalogPositionsFromMyGeneInfo","fetchParalogs","showParalogNeighborhoods","neighborhoods","starts","startJInt","overlayAnnotLength","getSearchedFromDescriptions","neighborhoodAnnots","neighborhood","annotStart","annotStop","overplotParalogs","sortByRelatedType","aName","bName","aColor","bColor","mergedDesc","descriptions","otherDesc","mergeAnnots","unmergedAnnots","seenAnnots","mergedAnnots","mergedAnnot","updated","sortedChrNames","seenNames","relevanceSortedAnnotsNamesByChr","annotNames","setRelatedAnnotDomIds","onFindGenesCallback","showAnnotLabels","otherType","numThisRelated","numOtherRelated","_didRelatedGenesFirstPlot","timestampFirstPlot","totalLastPlotDiff","totalFirstPlot","_relatedGenesFirstPlotType","analyzePlotTimes","adjustPlaceAndVisibility","ideoContainerDom","visibility","marginLeft","marginRight","overflowY","didAdjustIdeogramLegend","ideoDom","legendWidth","minWidth","plotRelatedGenes","plotGeneHints","headerTitle","href","initAnnotDescriptions","annotSel","cursor","oldDesc","processSearchedGene","relatedLegend","timeTotal","timeTotalFirstPlot","timeTotalLastPlotDiff","timeParalogs","timeInteractingGenes","timeSearchedGene","firstPlotType","analytics","relatedGenesAnalytics","analyzeRelatedGenes","onPlotFoundGenesCallback","getLegendName","nameText","citedLegend","kitConfig","globalKitDefaults","gpmls","interactingGene","searchedGeneGraphIds","interactingGeneGraphIds","ie","matchingGraphIds","graphIds","graphicsXml","graphic","endGraphRefs","numMatchingPoints","isConnectedToSourceGene","searchedGeneIndex","nodeName","graphRef","arrowHead","isStart","parseInteractionGraphic","detailInteractions","detailAllInteractions","enrichedIxns","isSameByPwid","isSame","isDirectionSameByPwid","isDirectionSame","directionsByPwid","ixnTypeReference","pwid","isRefMatch","thisIsSame","thisIxnTypeReference","determineIxnsInPathwayAreSame","setIsSame","leftTypes","rightTypes","directedTypes","firstIxnType","directionReference","isPwDirectionSame","pwFirstIxnType","pwDirectionReference","summarizeByDirection","summarizeInteractions","oldSummary","decorateInteractingGene","fullNameAndRank","isParalogNeighborhood","geneStructureHtml","geneStructureSvg","toggle","checked","getSpliceToggle","spanClass","getGeneStructureHtml","originalDisplay","sortedParalogs","firstRanked","decorateParalogNeighborhood","addedTooltipClickHandler","localName","geneDom","annotByName","handleTooltipClick","significance","citations","initSearchIdeogram","kitDefaults","clientFn","defaultFunction","newFunction","defaultFn","ideogram","onFindGenes","onPlotFoundGenes","getTooltipAnalytics","eutils","_fetch","method","chrAName","chrBName","aIsCP","bIsCP","aIsMT","bIsMT","aIsAP","bIsAP","aIsNuclear","bIsNuclear","chrTypes","getChrSortNamesAndTypes","localeCompare","numeric","isHuman","_initRelatedGenes","rawPath","legendName","geneLeadsDE","_initGeneLeads"],"sourceRoot":""}
\ No newline at end of file
diff --git a/package-lock.json b/package-lock.json
index 7cbb7ab2..947660f7 100644
--- a/package-lock.json
+++ b/package-lock.json
@@ -1,12 +1,12 @@
 {
   "name": "ideogram",
-  "version": "1.40.0",
+  "version": "1.41.0",
   "lockfileVersion": 2,
   "requires": true,
   "packages": {
     "": {
       "name": "ideogram",
-      "version": "1.40.0",
+      "version": "1.41.0",
       "license": "CC0-1.0",
       "dependencies": {
         "crossfilter2": "1.5.2",
diff --git a/package.json b/package.json
index 5f636ca9..69948730 100644
--- a/package.json
+++ b/package.json
@@ -1,6 +1,6 @@
 {
   "name": "ideogram",
-  "version": "1.40.0",
+  "version": "1.41.0",
   "description": "Chromosome visualization for the web",
   "main": "src/js/index.js",
   "directories": {
diff --git a/src/js/version.js b/src/js/version.js
index 1e0a12b9..deaaf179 100644
--- a/src/js/version.js
+++ b/src/js/version.js
@@ -1,2 +1,2 @@
-var version = '1.40.0';
+var version = '1.41.0';
 export default version;
