diff --git a/src/c/host-configs/tuolumne-4.18.0-x86_64-rocm@6.3.1-amdclang@18.0.0.cmake b/src/c/host-configs/tuolumne-4.18.0-x86_64-rocm@6.3.1-amdclang@18.0.0.cmake
new file mode 100644
index 00000000..7e47dfec
--- /dev/null
+++ b/src/c/host-configs/tuolumne-4.18.0-x86_64-rocm@6.3.1-amdclang@18.0.0.cmake
@@ -0,0 +1,19 @@
+##############################################################
+# Copyright 2021 Lawrence Livermore National Security, LLC
+# (c.f. AUTHORS, NOTICE.LLNS, COPYING)
+#
+# This file is part of the Flux resource manager framework.
+# For details, see https://github.com/flux-framework.
+#
+# SPDX-License-Identifier: LGPL-3.0
+##############################################################
+
+set(CMAKE_C_COMPILER "/opt/rocm-6.4.2/lib/llvm/bin/amdclang" CACHE PATH "")
+set(CMAKE_CXX_COMPILER "/opt/rocm-6.4.2/lib/llvm/bin/amdclang++" CACHE PATH "")
+
+set(PERFFLOWASPECT_WITH_CUDA "OFF" CACHE BOOL "")
+
+# To enable fine-grained profiling with Caliper, utilize the below options.
+# Caliper should be built with the same compilers as the PerfFlowAspect.
+# set(PERFFLOWASPECT_WITH_CALIPER ON CACHE BOOL "")
+# set(caliper_DIR "path-to-caliper-install-directory" CACHE PATH "")