NTR: lipoate-dependent carrier activity

[ValWood]

Please provide as much information as you can:

• Suggested term label:

lipoate-dependent carrier activity

• Definition (free text)

Mediating acyl group transfer and redox reactions through a covalently linked lipoate prosthetic group, facilitating interactions with cognate enzymes for processing or offloading of the acyl-bound or reduced lipoate intermediate.

source
based on proposed sibling def GO:0140414 phosphopantetheine-dependent carrier activity
def

(note to self make carrier protein activity broad synonym, and fix typo in covalently for GO:0140414)

• Reference, in format PMID:#######
  (REQUIRED) (to follow need to find)

• Gene product name and ID to be annotated to this term

https://www.pombase.org/gene/SPBP19A11.01
(I need for GO-CAM for glycine cleavage complex subunit H, but will also be used for other lipoate-dependent carriers)

• Parent term(s)

GO:0140104 molecular carrier activity

• Cross-references

• For enzymes, please provide RHEA and/or EC numbers.

• Can also provide MetaCyc, KEGG, Wikipedia, and other links.

• Any other information

[ValWood]

I thought this was useful (for inputs and outputs)

Why is H-Protein a Carrier?

It carries intermediates
    The H-protein's covalently attached lipoic acid acts as a swinging arm to pick up and deliver reaction intermediates.
    It specifically carries the aminomethyl (-CH₂-NH₃⁺) group from P-protein to T-protein.

It undergoes cyclic modifications
    The lipoic acid on the H-protein cycles between:
        Oxidized (active) form
        Aminomethylated form (after reaction with glycine)
        Reduced (dihydrolipoamide) form (after interacting with T-protein)
    The L-protein then regenerates the oxidized state, allowing the cycle to continue.

It does not catalyze reactions itself
    Unlike enzymes (which actively catalyze chemical transformations), the H-protein simply transfers chemical groups between enzymes.

and from
https://www.uniprot.org/uniprotkb/Q9HDV9/entry
The H protein shuttles the methylamine group of glycine from the P protein to the T protein

but I still didn't find a reference yet

[deustp01]

There is an exactly analogous carrier subprocess involved in the reactions mediated by the2-oxoacid (alpha-ketoacid) dehydrogenase complexes, whose ontology terms @sjm41 revised and reorganized a few months ago. Any useful precedents or references there?