diff --git a/CMakeLists.txt b/CMakeLists.txt
index f07a159e34fae..354911775117a 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -223,7 +223,7 @@ if(CMAKE_SYSTEM_NAME STREQUAL "Darwin")
   try_append_linker_flag("-Wl,-headerpad_max_install_names" TARGET core_base_interface)
 endif()
 
-if(CMAKE_CROSSCOMPILING)
+if(BITCOIN_BUILD_WITH_DEPENDS)
   target_compile_definitions(core_base_interface INTERFACE ${DEPENDS_COMPILE_DEFINITIONS})
   target_compile_options(core_base_interface INTERFACE "$<$<COMPILE_LANGUAGE:C>:${DEPENDS_C_COMPILER_FLAGS}>")
   target_compile_options(core_base_interface INTERFACE "$<$<COMPILE_LANGUAGE:CXX>:${DEPENDS_CXX_COMPILER_FLAGS}>")
diff --git a/cmake/module/CrossPkgConfig.cmake b/cmake/module/CrossPkgConfig.cmake
index cbd6f3c27b288..fba6ac80a697e 100644
--- a/cmake/module/CrossPkgConfig.cmake
+++ b/cmake/module/CrossPkgConfig.cmake
@@ -31,7 +31,7 @@ function(remove_isystem_from_include_directories_internal target)
 endfunction()
 
 macro(cross_pkg_check_modules prefix)
-  if(CMAKE_CROSSCOMPILING)
+  if(BITCOIN_BUILD_WITH_DEPENDS)
     set(pkg_config_path_saved "$ENV{PKG_CONFIG_PATH}")
     set(pkg_config_libdir_saved "$ENV{PKG_CONFIG_LIBDIR}")
     set(ENV{PKG_CONFIG_PATH} ${PKG_CONFIG_PATH})
diff --git a/cmake/module/Maintenance.cmake b/cmake/module/Maintenance.cmake
index 9bef503f3a727..c9e090adcd0e5 100644
--- a/cmake/module/Maintenance.cmake
+++ b/cmake/module/Maintenance.cmake
@@ -37,7 +37,7 @@ function(add_maintenance_targets)
   else()
     set(exe_format ELF)
   endif()
-  if(CMAKE_CROSSCOMPILING)
+  if(BITCOIN_BUILD_WITH_DEPENDS)
     list(JOIN DEPENDS_C_COMPILER_WITH_LAUNCHER " " c_compiler_command)
   else()
     set(c_compiler_command ${CMAKE_C_COMPILER})
diff --git a/depends/Makefile b/depends/Makefile
index ab91b5b72a317..062cb0f5635b3 100644
--- a/depends/Makefile
+++ b/depends/Makefile
@@ -259,9 +259,16 @@ $(host_prefix)/share/config.site : config.site.in $(host_prefix)/.stamp_$(final_
             $< > $@
 	touch $@
 
+ifeq ($(host),$(build))
+  crosscompiling=FALSE
+else
+  crosscompiling=TRUE
+endif
+
 $(host_prefix)/share/toolchain.cmake : toolchain.cmake.in $(host_prefix)/.stamp_$(final_build_id)
 	@mkdir -p $(@D)
-	sed -e 's|@host_system@|$($(host_os)_cmake_system)|' \
+	sed -e 's|@depends_crosscompiling@|$(crosscompiling)|' \
+            -e 's|@host_system@|$($(host_os)_cmake_system)|' \
             -e 's|@host_arch@|$(host_arch)|' \
             -e 's|@CC@|$(host_CC)|' \
             -e 's|@CXX@|$(host_CXX)|' \
diff --git a/depends/toolchain.cmake.in b/depends/toolchain.cmake.in
index a8ef8f6264a9e..ca893b0afc33d 100644
--- a/depends/toolchain.cmake.in
+++ b/depends/toolchain.cmake.in
@@ -4,8 +4,13 @@
 
 # This file is expected to be highly volatile and may still change substantially.
 
-set(CMAKE_SYSTEM_NAME @host_system@)
-set(CMAKE_SYSTEM_PROCESSOR @host_arch@)
+set(BITCOIN_BUILD_WITH_DEPENDS TRUE)
+
+set(DEPENDS_CROSSCOMPILING @depends_crosscompiling@)
+if(DEPENDS_CROSSCOMPILING)
+  set(CMAKE_SYSTEM_NAME @host_system@)
+  set(CMAKE_SYSTEM_PROCESSOR @host_arch@)
+endif()
 
 function(split_compiler_launcher env_compiler launcher compiler)
   set(${launcher})
diff --git a/src/qt/CMakeLists.txt b/src/qt/CMakeLists.txt
index 45b8b50da2334..787e32fb570e4 100644
--- a/src/qt/CMakeLists.txt
+++ b/src/qt/CMakeLists.txt
@@ -35,7 +35,7 @@ if(BUILD_GUI_TESTS)
   list(APPEND qt_components Test)
 endif()
 
-if(CMAKE_CROSSCOMPILING)
+if(BITCOIN_BUILD_WITH_DEPENDS)
   # The find_package(Qt ...) function internally uses find_library()
   # calls for all dependencies to ensure their availability.
   # In turn, the find_library() inspects the well-known locations