diff --git a/ci/test/00_setup_env_i686_multiprocess.sh b/ci/test/00_setup_env_i686_multiprocess.sh
index 521c82c3ef0e5..5810ae8639fa8 100755
--- a/ci/test/00_setup_env_i686_multiprocess.sh
+++ b/ci/test/00_setup_env_i686_multiprocess.sh
@@ -13,6 +13,11 @@ export PACKAGES="llvm clang g++-multilib"
 export DEP_OPTS="DEBUG=1 MULTIPROCESS=1"
 export GOAL="install"
 export TEST_RUNNER_EXTRA="--v2transport"
-export BITCOIN_CONFIG="-DCMAKE_BUILD_TYPE=Debug -DCMAKE_C_COMPILER='clang;-m32' -DCMAKE_CXX_COMPILER='clang++;-m32' \
--DCMAKE_CXX_FLAGS='-DBOOST_MULTI_INDEX_ENABLE_SAFE_MODE -Wno-error=documentation'"
+export BITCOIN_CONFIG="\
+ -DCMAKE_BUILD_TYPE=Debug \
+ -DCMAKE_C_COMPILER='clang;-m32' \
+ -DCMAKE_CXX_COMPILER='clang++;-m32' \
+ -DCMAKE_CXX_FLAGS='-Wno-error=documentation' \
+ -DAPPEND_CPPFLAGS='-DBOOST_MULTI_INDEX_ENABLE_SAFE_MODE' \
+"
 export BITCOIND=bitcoin-node  # Used in functional tests
diff --git a/ci/test/00_setup_env_native_asan.sh b/ci/test/00_setup_env_native_asan.sh
index 3b0dc46b6808d..173b5b71c9552 100755
--- a/ci/test/00_setup_env_native_asan.sh
+++ b/ci/test/00_setup_env_native_asan.sh
@@ -22,9 +22,13 @@ export CONTAINER_NAME=ci_native_asan
 export PACKAGES="systemtap-sdt-dev clang-18 llvm-18 libclang-rt-18-dev python3-zmq qtbase5-dev qttools5-dev qttools5-dev-tools libevent-dev libboost-dev libdb5.3++-dev libminiupnpc-dev libnatpmp-dev libzmq3-dev libqrencode-dev libsqlite3-dev ${BPFCC_PACKAGE}"
 export NO_DEPENDS=1
 export GOAL="install"
-export BITCOIN_CONFIG="-DWITH_USDT=ON -DWITH_ZMQ=ON -DWARN_INCOMPATIBLE_BDB=OFF -DBUILD_GUI=ON \
--DSANITIZERS=address,float-divide-by-zero,integer,undefined \
--DCMAKE_C_COMPILER=clang-18 -DCMAKE_CXX_COMPILER=clang++-18 \
--DCMAKE_C_FLAGS='-ftrivial-auto-var-init=pattern' \
--DCMAKE_CXX_FLAGS='-DARENA_DEBUG -DDEBUG_LOCKORDER -ftrivial-auto-var-init=pattern'"
+export BITCOIN_CONFIG="\
+ -DWITH_USDT=ON -DWITH_ZMQ=ON -DWARN_INCOMPATIBLE_BDB=OFF -DBUILD_GUI=ON \
+ -DSANITIZERS=address,float-divide-by-zero,integer,undefined \
+ -DCMAKE_C_COMPILER=clang-18 \
+ -DCMAKE_CXX_COMPILER=clang++-18 \
+ -DCMAKE_C_FLAGS='-ftrivial-auto-var-init=pattern' \
+ -DCMAKE_CXX_FLAGS='-ftrivial-auto-var-init=pattern' \
+ -DAPPEND_CPPFLAGS='-DARENA_DEBUG -DDEBUG_LOCKORDER' \
+"
 export CCACHE_MAXSIZE=300M
diff --git a/ci/test/00_setup_env_native_fuzz.sh b/ci/test/00_setup_env_native_fuzz.sh
index f2a627e71ef27..4f502c444e02e 100755
--- a/ci/test/00_setup_env_native_fuzz.sh
+++ b/ci/test/00_setup_env_native_fuzz.sh
@@ -15,9 +15,13 @@ export RUN_FUNCTIONAL_TESTS=false
 export RUN_FUZZ_TESTS=true
 export GOAL="install"
 export CI_CONTAINER_CAP="--cap-add SYS_PTRACE"  # If run with (ASan + LSan), the container needs access to ptrace (https://github.com/google/sanitizers/issues/764)
-export BITCOIN_CONFIG="-DENABLE_FUZZ=ON -DSANITIZERS=fuzzer,address,undefined,float-divide-by-zero,integer \
--DCMAKE_C_COMPILER=clang-18 -DCMAKE_CXX_COMPILER=clang++-18 \
--DCMAKE_C_FLAGS='-ftrivial-auto-var-init=pattern' \
--DCMAKE_CXX_FLAGS='-ftrivial-auto-var-init=pattern'"
+export BITCOIN_CONFIG="\
+ -DENABLE_FUZZ=ON \
+ -DSANITIZERS=fuzzer,address,undefined,float-divide-by-zero,integer \
+ -DCMAKE_C_COMPILER=clang-18 \
+ -DCMAKE_CXX_COMPILER=clang++-18 \
+ -DCMAKE_C_FLAGS='-ftrivial-auto-var-init=pattern' \
+ -DCMAKE_CXX_FLAGS='-ftrivial-auto-var-init=pattern' \
+"
 export CCACHE_MAXSIZE=200M
 export LLVM_SYMBOLIZER_PATH="/usr/bin/llvm-symbolizer-18"
diff --git a/ci/test/00_setup_env_native_fuzz_with_msan.sh b/ci/test/00_setup_env_native_fuzz_with_msan.sh
index 50f2064dc38ca..e9b315f50334a 100755
--- a/ci/test/00_setup_env_native_fuzz_with_msan.sh
+++ b/ci/test/00_setup_env_native_fuzz_with_msan.sh
@@ -18,8 +18,11 @@ export PACKAGES="ninja-build"
 export DEP_OPTS="DEBUG=1 NO_BDB=1 NO_QT=1 CC=clang CXX=clang++ CFLAGS='${MSAN_FLAGS}' CXXFLAGS='${MSAN_AND_LIBCXX_FLAGS}'"
 export GOAL="install"
 # _FORTIFY_SOURCE is not compatible with MSAN.
-export BITCOIN_CONFIG="-DENABLE_FUZZ=ON -DSANITIZERS=fuzzer,memory -DCMAKE_CXX_FLAGS='-DBOOST_MULTI_INDEX_ENABLE_SAFE_MODE' \
--DAPPEND_CPPFLAGS='-U_FORTIFY_SOURCE'"
+export BITCOIN_CONFIG="\
+ -DENABLE_FUZZ=ON \
+ -DSANITIZERS=fuzzer,memory \
+ -DAPPEND_CPPFLAGS='-DBOOST_MULTI_INDEX_ENABLE_SAFE_MODE -U_FORTIFY_SOURCE' \
+"
 export USE_MEMORY_SANITIZER="true"
 export RUN_UNIT_TESTS="false"
 export RUN_FUNCTIONAL_TESTS="false"
diff --git a/ci/test/00_setup_env_native_fuzz_with_valgrind.sh b/ci/test/00_setup_env_native_fuzz_with_valgrind.sh
index 38a922cd69e7e..e1557091c2cef 100755
--- a/ci/test/00_setup_env_native_fuzz_with_valgrind.sh
+++ b/ci/test/00_setup_env_native_fuzz_with_valgrind.sh
@@ -15,5 +15,10 @@ export RUN_FUNCTIONAL_TESTS=false
 export RUN_FUZZ_TESTS=true
 export FUZZ_TESTS_CONFIG="--valgrind"
 export GOAL="install"
-export BITCOIN_CONFIG="-DENABLE_FUZZ=ON -DSANITIZERS=fuzzer -DCMAKE_C_COMPILER=clang-16 -DCMAKE_CXX_COMPILER=clang++-16"
+export BITCOIN_CONFIG="\
+ -DENABLE_FUZZ=ON \
+ -DSANITIZERS=fuzzer \
+ -DCMAKE_C_COMPILER=clang-16 \
+ -DCMAKE_CXX_COMPILER=clang++-16 \
+"
 export CCACHE_MAXSIZE=200M
diff --git a/ci/test/00_setup_env_native_previous_releases.sh b/ci/test/00_setup_env_native_previous_releases.sh
index 5ef53f4a19f74..2482e545e1354 100755
--- a/ci/test/00_setup_env_native_previous_releases.sh
+++ b/ci/test/00_setup_env_native_previous_releases.sh
@@ -16,6 +16,12 @@ export RUN_UNIT_TESTS_SEQUENTIAL="true"
 export RUN_UNIT_TESTS="false"
 export GOAL="install"
 export DOWNLOAD_PREVIOUS_RELEASES="true"
-export BITCOIN_CONFIG="-DWITH_ZMQ=ON -DBUILD_GUI=ON -DREDUCE_EXPORTS=ON -DCMAKE_BUILD_TYPE=Debug \
--DCMAKE_C_FLAGS='-funsigned-char' -DCMAKE_C_FLAGS_DEBUG='-g0 -O2' \
--DCMAKE_CXX_FLAGS='-DBOOST_MULTI_INDEX_ENABLE_SAFE_MODE -funsigned-char' -DCMAKE_CXX_FLAGS_DEBUG='-g0 -O2'"
+export BITCOIN_CONFIG="\
+ -DWITH_ZMQ=ON -DBUILD_GUI=ON -DREDUCE_EXPORTS=ON \
+ -DCMAKE_BUILD_TYPE=Debug \
+ -DCMAKE_C_FLAGS='-funsigned-char' \
+ -DCMAKE_C_FLAGS_DEBUG='-g0 -O2' \
+ -DCMAKE_CXX_FLAGS='-funsigned-char' \
+ -DCMAKE_CXX_FLAGS_DEBUG='-g0 -O2' \
+ -DAPPEND_CPPFLAGS='-DBOOST_MULTI_INDEX_ENABLE_SAFE_MODE' \
+"
diff --git a/ci/test/00_setup_env_native_tidy.sh b/ci/test/00_setup_env_native_tidy.sh
index fd3b7bd45e106..beebf180adc75 100755
--- a/ci/test/00_setup_env_native_tidy.sh
+++ b/ci/test/00_setup_env_native_tidy.sh
@@ -16,7 +16,11 @@ export RUN_FUNCTIONAL_TESTS=false
 export RUN_FUZZ_TESTS=false
 export RUN_TIDY=true
 export GOAL="install"
-export BITCOIN_CONFIG="-DWARN_INCOMPATIBLE_BDB=OFF -DENABLE_HARDENING=OFF \
--DCMAKE_C_COMPILER=clang-${TIDY_LLVM_V} -DCMAKE_CXX_COMPILER=clang++-${TIDY_LLVM_V} \
--DCMAKE_C_FLAGS_RELWITHDEBINFO='-O0 -g0' -DCMAKE_CXX_FLAGS_RELWITHDEBINFO='-O0 -g0'"
+export BITCOIN_CONFIG="\
+ -DWARN_INCOMPATIBLE_BDB=OFF -DENABLE_HARDENING=OFF \
+ -DCMAKE_C_COMPILER=clang-${TIDY_LLVM_V} \
+ -DCMAKE_CXX_COMPILER=clang++-${TIDY_LLVM_V} \
+ -DCMAKE_C_FLAGS_RELWITHDEBINFO='-O0 -g0' \
+ -DCMAKE_CXX_FLAGS_RELWITHDEBINFO='-O0 -g0' \
+"
 export CCACHE_MAXSIZE=200M
diff --git a/ci/test/00_setup_env_native_tsan.sh b/ci/test/00_setup_env_native_tsan.sh
index 519575dcd4f06..7b2767f19f5f5 100755
--- a/ci/test/00_setup_env_native_tsan.sh
+++ b/ci/test/00_setup_env_native_tsan.sh
@@ -12,4 +12,4 @@ export PACKAGES="clang-18 llvm-18 libclang-rt-18-dev libc++abi-18-dev libc++-18-
 export DEP_OPTS="CC=clang-18 CXX='clang++-18 -stdlib=libc++'"
 export GOAL="install"
 export BITCOIN_CONFIG="-DWITH_ZMQ=ON -DSANITIZERS=thread \
--DCMAKE_CXX_FLAGS='-DARENA_DEBUG -DDEBUG_LOCKORDER -DDEBUG_LOCKCONTENTION'"
+-DAPPEND_CPPFLAGS='-DARENA_DEBUG -DDEBUG_LOCKORDER -DDEBUG_LOCKCONTENTION'"
diff --git a/ci/test/00_setup_env_native_valgrind.sh b/ci/test/00_setup_env_native_valgrind.sh
index f697b3d7c78af..341f267d949ba 100755
--- a/ci/test/00_setup_env_native_valgrind.sh
+++ b/ci/test/00_setup_env_native_valgrind.sh
@@ -13,4 +13,9 @@ export USE_VALGRIND=1
 export NO_DEPENDS=1
 export TEST_RUNNER_EXTRA="--exclude feature_init,rpc_bind,feature_bind_extra"  # feature_init excluded for now, see https://github.com/bitcoin/bitcoin/issues/30011 ; bind tests excluded for now, see https://github.com/bitcoin/bitcoin/issues/17765#issuecomment-602068547
 export GOAL="install"
-export BITCOIN_CONFIG="-DWITH_ZMQ=ON -DWARN_INCOMPATIBLE_BDB=OFF -DBUILD_GUI=OFF -DCMAKE_C_COMPILER=clang-16 -DCMAKE_CXX_COMPILER=clang++-16" # TODO enable GUI
+# TODO enable GUI
+export BITCOIN_CONFIG="\
+ -DWITH_ZMQ=ON -DWARN_INCOMPATIBLE_BDB=OFF -DBUILD_GUI=OFF \
+ -DCMAKE_C_COMPILER=clang-16 \
+ -DCMAKE_CXX_COMPILER=clang++-16 \
+"