diff --git a/contrib/guix/guix-build b/contrib/guix/guix-build
index 731355598cb13..870938cb52acf 100755
--- a/contrib/guix/guix-build
+++ b/contrib/guix/guix-build
@@ -75,12 +75,9 @@ mkdir -p "$VERSION_BASE"
 
 # Default to building for all supported HOSTs (overridable by environment)
 # powerpc64le-linux-gnu currently disabled due non-determinism issues across build arches.
-# TODO: Re-enable macOS hosts.
-# export HOSTS="${HOSTS:-x86_64-linux-gnu arm-linux-gnueabihf aarch64-linux-gnu riscv64-linux-gnu powerpc64-linux-gnu
-#                        x86_64-w64-mingw32
-#                        x86_64-apple-darwin arm64-apple-darwin}"
 export HOSTS="${HOSTS:-x86_64-linux-gnu arm-linux-gnueabihf aarch64-linux-gnu riscv64-linux-gnu powerpc64-linux-gnu
-                       x86_64-w64-mingw32}"
+                       x86_64-w64-mingw32
+                       x86_64-apple-darwin arm64-apple-darwin}"
 
 # Usage: distsrc_for_host HOST
 #
diff --git a/contrib/guix/libexec/build.sh b/contrib/guix/libexec/build.sh
index ad189d591fc5c..ed47af6603f85 100755
--- a/contrib/guix/libexec/build.sh
+++ b/contrib/guix/libexec/build.sh
@@ -284,7 +284,7 @@ mkdir -p "$DISTSRC"
     # Install built Bitcoin Core to $INSTALLPATH
     case "$HOST" in
         *darwin*)
-            make install-strip DESTDIR="${INSTALLPATH}" ${V:+V=1}
+            cmake --install build --strip --prefix "${INSTALLPATH}" ${V:+--verbose}
             ;;
         *)
             cmake --install build --prefix "${INSTALLPATH}" ${V:+--verbose}
@@ -293,13 +293,12 @@ mkdir -p "$DISTSRC"
 
     case "$HOST" in
         *darwin*)
-            make osx_volname ${V:+V=1}
-            make deploydir ${V:+V=1}
+            cmake --build build --target deploy ${V:+--verbose}
+            mv build/dist/Bitcoin-Core.zip "${OUTDIR}/${DISTNAME}-${HOST}-unsigned.zip"
             mkdir -p "unsigned-app-${HOST}"
             cp  --target-directory="unsigned-app-${HOST}" \
-                osx_volname \
                 contrib/macdeploy/detached-sig-create.sh
-            mv --target-directory="unsigned-app-${HOST}" dist
+            mv --target-directory="unsigned-app-${HOST}" build/dist
             (
                 cd "unsigned-app-${HOST}"
                 find . -print0 \
@@ -308,7 +307,6 @@ mkdir -p "$DISTSRC"
                     | gzip -9n > "${OUTDIR}/${DISTNAME}-${HOST}-unsigned.tar.gz" \
                     || ( rm -f "${OUTDIR}/${DISTNAME}-${HOST}-unsigned.tar.gz" && exit 1 )
             )
-            make deploy ${V:+V=1} OSX_ZIP="${OUTDIR}/${DISTNAME}-${HOST}-unsigned.zip"
             ;;
     esac
     (
@@ -389,7 +387,7 @@ mkdir -p "$DISTSRC"
 
     case "$HOST" in
         *mingw*)
-            cp -rf --target-directory=. "${DISTSRC}/contrib/windeploy"
+            cp -rf --target-directory=. contrib/windeploy
             (
                 cd ./windeploy
                 mkdir -p unsigned